Podcasts about coq10

880. CoQ10 shows up in cellular energy production, in antioxidant defense, and increasingly, in marketing aimed at anyone over fifty. It's sold for energy, for athletic performance, and especially to the millions of people taking a statin, since those medications really do lower CoQ10 levels in the blood.So who genuinely benefits? In this episode, Monica sorts the credible case from the promotional one. She covers why your body makes most of its own CoQ10 rather than getting it from food, what statins actually do to your levels and whether that matters, and what the evidence says about the claim that CoQ10 relieves statin-related muscle pain. You'll also hear the better-validated steps to try before reaching for a supplement, why she compares this situation to glucosamine and joint pain, how to take CoQ10 if you decide to test it yourself, and why the energy-boosting claims deserve real skepticism.Join us for a live show taping on September 17 in New York City. Details at wellnessworkshere.com/live.New to Nutrition Diva? Check out our special Spotify playlist for a collection of the best episodes curated by our team and Monica herself! Follow Nutrition Diva on Facebook and subscribe to the newsletter for more diet and nutrition tips. Find out about Monica's keynotes and other programs at WellnessWorksHere.comNutrition Diva is a part of the Quick and Dirty Tips podcast network. ReferencesMarcoff L, Thompson PD. The role of coenzyme Q10 in statin-associated myopathy: a systematic review - PubMed Grundy SM, Stone N. AHA Guideline on the Management of Blood Cholesterol: PubMed Kovacic S, Habicht SD, Effects of coenzyme Q10 supplementation on myopathy in statin-treated patients: a systematic review and meta-analysis - PubMed Warden BA, Guyton JR, Assessment and management of statin-associated muscle symptoms (SAMS): A clinical perspective from the National Lipid Association - PubMed Stroes ES, et al. Statin-associated muscle symptoms: impact on statin therapy - PubMed Iatan I, Mancini J Statin associated muscle symptoms (SAMS): strategies for prevention, assessment and management - PubMed Deng H, Song T Coenzyme Q10 supplementation increases blood concentrations but shows limited and inconsistent effects on exercise performance: a systematic review and meta-analysis - PubMed Related Episodes871687101 Hosted on Acast. See acast.com/privacy for more information.

Thank you for joining us for our 2nd Cabral HouseCall of the weekend!   I'm looking forward to sharing with you some of our community's questions that have come in over the past few weeks…   Alyssa: Hi! After having our first baby I started getting eczema on my hands. Very itchy, small bumps with clear liquid in them. It flared up again after having our second baby and my hands are now extremely dry, cracked, have the little bumps and what I've read could be a wet eczema. Any idea why this is happening or how to clear it up? Thank you!      M: Hi Dr. Cabral, Firstly, thank you for such a brilliant podcast. I've learned so much from you over the years and really appreciate the practical way you share your knowledge. My 10-year-old son was recently diagnosed with a plantar fibroma after we noticed a firm lump in the arch of his foot and had it confirmed by ultrasound. I listened to your HouseCall episode #2011 where you discussed plantar fibromatosis and recommended proteolytic enzymes for adults. What approach would you recommend for a 10-year-old? Are there any underlying factors you would investigate, or natural/conservative therapies you would recommend to help prevent the fibroma from growing or potentially reduce it? He is very healthy and active and currently takes DNS, magnesium and omega-3s. Thank you.       Mohamed: Hello Dr.Cabral, just beginning my 7 day detox. Looking forward to it, Ive been researching a lot lately about ampK and Nrf2. The benefits of up regulation of ampk are incredible, I know you also touched on this. But can you elaborate and give a actionable plan with diet, exercise, supplements to boost ampk and get benefits from Lipid Control • Glucose • Oxidative Stress • Inflammatin • Endothelial •Toxic Protection • Apoptosis of maligniant cells and not in normal cells in response to a stress. From my research, berberine came up. But are there others? Thanks!       Jennifer: Our pediatric dentist has recommended that my 4 and a half year old daughter get crowns on every tooth because she was born with a bright white line along the gum line of every tooth and within a year had cavities on every single tooth. We got filings and silver paint to try to remedy the situation but within a year after all the fillings either came out or more cavities erupted on every tooth. We brush twice a day and against my original wishes do use fluoride for her now as well. I think we have to move forward with the dental work but can you tell me which lab tests I should run to make sure there's nothing else severe going on. I can use my subscription perk to do HTMA but if I need to do more I can. Our dentist said she had only seen one other case like this in her 25 years.       Mary: Had bloodwork run. I take 2.8g Omega 3 (1,400 EPA, 1,000 DHA), Vit D 5,000, Garlic (Aged fermented black garlic 600 mg, garlic allium (400 mg), Berberine 2x day (Equilife), cell boost, Nattokinase (Equilife), red yeast rice 1,200 mg includes 200 mg coQ10, and other supplements not related to what I'm writing about. My total cholesterol went from 210 to 226 from two years ago, triglicerides 119 to 330, HDL 61 to 46 & LDL 126 to 133. I eat very little meat, although I do eat cheese and sweets. I walk 15,000-20,000 steps a day. Only changes I can think of is in the last 1 1/2 years I have a way out of the ordinary amount of stress because of several factors. I ate (1/4c) steel cut oats every morning for years & recently switched to DNS shakes. Added psyllium. Not sure what else to do.     Thank you for tuning into this weekend's Cabral HouseCalls and be sure to check back tomorrow for our Mindset & Motivation Monday show to get your week started off right!   - - - Show Notes and Resources: StephenCabral.com/3873 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!  

On this episode of Vitality Radio, Jared breaks down CoQ10 and PQQ from the ground up. You'll learn how CoQ10 supports mitochondrial energy production, antioxidant defense, cardiovascular wellness, and healthy aging, plus why your natural production declines over time. Jared explains the difference between ubiquinone and ubiquinol, how age and digestion may influence which form makes sense, what to look for in a high-quality naturally fermented CoQ10, and how dosing can vary depending on your goals. He also explores how statin medications can affect CoQ10 levels and why PQQ may be the perfect partner by supporting mitochondrial biogenesis. Finally, Jared explains why both CoQ10 and PQQ earned a place in the latest Ultimate Vitality Multi formula.CoQ10, Ubiquinol, & PQQ Products DiscussedAdditional Information:255: Strolling Down the Costco Supplement Aisle. What to Look for on the Label Before Buying Your Supplements.662: Ultimate Vitality Multi: The Anatomy of a Premium Multivitamin667: Nattokinase vs. Statins: The Plaque Study You Were Never Told About613: Bad Medicine: Rethinking Cholesterol, Statins, and Heart Health449: Suppressive Medicine: How Big Pharma and FDA Get It Wrong With StatinsVisit the podcast website here: VitalityRadio.comYou can follow @vitalitynutritionbountiful and @vitalityradio on Instagram, or Vitality Radio and Vitality Nutrition on Facebook. Join us also in the Vitality Radio Podcast Listener Community on Facebook. Shop the products that Jared mentions at vitalitynutrition.com. Let us know your thoughts about this episode using the hashtag #vitalityradio and please rate and review us on Apple Podcasts. Thank you!Just a reminder that this podcast is for educational purposes only. The FDA has not evaluated the podcast. The information is not intended to diagnose, treat, cure, or prevent any disease. The advice given is not intended to replace the advice of your medical professional.This podcast is produced by DrTalks.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://drtalks.com/podcast-service/

What happens when doctors misunderstand Ehlers-Danlos syndromes (EDS) and hypermobility spectrum disorders (HSD)? Sometimes the consequences go far beyond frustration or delayed treatment. In this episode of Bendy Bodies with the Hypermobility MD, Dr. Linda Bluestein is joined by Dr. Ina Stephens, Associate Director of the UVA Health EDS and Hypermobility Disorder Center, to answer listener questions about MCAS, gut health, circadian rhythm, migraine, pediatric hypermobility, and more. They also confront a disturbing reality for some families navigating poorly understood conditions: medical gaslighting, misdiagnosis, and inappropriate Munchausen-by-proxy referrals. Can you support a healthy gut microbiome with MCAS if fermented foods trigger symptoms? Drs. Bluestein and Stephens discuss the role of dietary fiber, polyphenol-rich foods, exercise, and thoughtful antibiotic use, including why the narrowest effective antibiotic may be preferable when treatment is necessary. They also explain why resetting a disrupted circadian rhythm involves more than simply going to bed earlier, and how morning light exposure can help shift the body's internal clock. Then the conversation turns to migraine management in hypermobile patients. Dr. Stephens shares her approach to supplements and medications, including magnesium glycinate, CoQ10, and CGRP-targeting medications such as ubrogepant (Ubrelvy,) while explaining why Botox (onabotulinumtoxin A) is not usually a first-line migraine treatment and may be problematic for people with significant craniocervical instability. The episode also tackles a question with major implications for the next generation: Should children be evaluated for hypermobile EDS earlier (hEDS)? Dr. Stephens explains how delayed recognition can contribute to years of orthopedic problems, psychological distress, inappropriate diagnoses, and missed opportunities for prevention and support. Finally, the episode closes with a Hypermobility Hack on low dose naltrexone (LDN): how it may work, why benefits can take time to appear, and why patience matters when evaluating whether it is helping. Takeaways: Could the wrong antibiotic choice create problems long after the infection is gone? Why might morning sunlight matter more than forcing yourself to go to bed earlier? When could Botox actually make headaches and neck symptoms worse in someone with hypermobility? How can missed or delayed recognition of hEDS in childhood affect orthopedic and mental health outcomes years later? What happens when physicians misunderstand EDS so profoundly that a family is suspected of fabricating illness? Why can low dose naltrexone seem like it is “not working” before it has had enough time to take effect? Want to learn more about the UVA EDS Center? For Appointments and Questions: RUVAEDSCenter@uvahealth.org UVA EDS: https://www.uvahealth.com/healthy-practice/advancing-care-through-ehlers-danlos-clinic UVA EDS FAQ: https://www.uvahealth.com/support/eds/faq UVA Pediatric Integrative Medicine: https://childrens.uvahealth.com/specialties/integrative-health Want more Dr. Linda Bluestein, MD? Website: https://www.hypermobilitymd.com/ YouTube: https://www.youtube.com/@bendybodiespodcast Instagram: ⁠⁠⁠⁠https://www.instagram.com/hypermobilitymd/⁠⁠⁠⁠ Facebook: ⁠⁠⁠⁠https://www.facebook.com/BendyBodiesPodcast⁠⁠⁠⁠ X: ⁠⁠⁠⁠https://twitter.com/BluesteinLinda⁠⁠⁠⁠ LinkedIn: ⁠⁠⁠⁠https://www.linkedin.com/in/hypermobilitymd/⁠⁠⁠⁠ Newsletter: ⁠⁠⁠⁠https://hypermobilitymd.substack.com/ Shop my Amazon store ⁠⁠⁠ https://www.amazon.com/shop/hypermobilitymd Dr. Bluestein's Recommended Herbs, Supplements and Care Necessities: https://us.fullscript.com/welcome/hypermobilitymd/store-start Thank YOU so much for tuning in. We hope you found this episode informative, inspiring, useful, validating, and enjoyable. Join us on the next episode for YOUR time to level up your knowledge about hypermobility disorders and the people who have them. Join YOUR Bendy Bodies community at ⁠⁠https://www.bendybodiespodcast.com/⁠⁠. YOUR bendy body is our highest priority!⁠⁠ Learn more about Human Content at ⁠⁠⁠http://www.human-content.com⁠⁠⁠ Podcast Advertising/Business Inquiries: ⁠⁠⁠sales@human-content.com⁠⁠⁠ Part of the Human Content Podcast Network Go http://www.AquaTru.com now for 20% off (your purifier) using promo code BENDY. FTC: This video is not sponsored. Links are commissionable, meaning I may earn commission from purchases made through links. Chapters: 00:00 EDS Starts Early00:34 Meet Dr Ina Stephens02:12 Fermented Foods MCAS02:39 Microbiome Support Basics10:47 Antibiotics Probiotics15:49 Medical Distrust CPS Risk29:31 Migraine Treatments Botox41:16 Feverfew Dosage Basics41:30 Avoiding Rebound Headaches43:12 CGRP Rescue Meds Explained44:51 Why Diagnose EDS Early49:05 Early Intervention and Prevention56:42 Parenting Tips and Clinic Access01:06:54 LDN Patience and Closing Resources Learn more about your ad choices. Visit megaphone.fm/adchoices

Today we're going to break down the protein supplement market and talk about what protein actually does, what makes one protein product higher quality versus another, ingredients to be cautious about, and ultimately, help you decide which protein supplement to choose and why.  Read the Full Episode Transcript: https://pepties.com/protein-supplements-what-you-need-to-know/   Related Links/Products Mentioned: Peptide Podcast Partners Page https://pepties.com/partners/ Buy Peptides online at BioLongevity Labs: Use our link and enter COUPON CODE: PEPTIDEPODCAST  at checkout to receive 15% off your total order:  https://go.biolongevitylabs.com/SH5C Momentous Supplements (we use Creatine, Vital Aminos, Whey Protein) https://crrnt.app/MOME/OqGQOxGA LMNT – More Salt, Not Less.  https://elementallabs.refr.cc/default/u/johnjavit Thorne Supplements (we use Omega-3 with CoQ10, Red Yeast Rice, Zinc) https://get.aspr.app/SH1KvW Organifi Creatine and Shilajit Gummies http://rwrd.io/rlbkajm?c MitoZen (methylene blue for Cognitive Function, Anti-Aging, Mental Clarity) https://www.mitozen.com/ref/cnlwiztypt/ For skin and hair health (Copper Tripeptide-1)  Visit Luminose by Entera for an exclusive offer for Peptide Podcast listeners!  ** Promo code PEPTIDEPODCAST at checkout for 10% off an order or 10% off the first month of a subscribe-and-save. ** https://www.enteraskincare.com/?rfsn=8906839.f93c72 NAD+ Push Patch: https://www.pushpatch.com/

Statin side effects go far beyond what most people realize. Discover what statins do to your body and the surprising statin side effects most people don't know about.

Renowned integrative medicine physician, board-certified internist, and researcher Dr. Jacob Teitelbaum discusses his new book, "Pain Relief in 4 Simple Steps," and the growing chronic pain epidemic (one in four U.S. adults; about 7% debilitating). Teitelbaum argues most pain is treatable by addressing root causes and describes four biochemical pain types—muscle pain from low energy, inflammatory pain, neuropathic pain, and brain pain (microglial activation)—alongside structural, biophysical, and mind-body contributors. They discuss risks of NSAIDs and Tylenol, diet's role (processed foods, sugar, seed oils), and strategies such as an Energy Revitalization Drink Mix, SHINE protocol, curcumin with turmeric oils plus boswellia (Curamin), omega-3 support, magnesium, B12 issues with metformin/GLP drugs, lipoic acid for neuropathy and burning mouth syndrome, and migraine support with high-dose riboflavin and magnesium. He also cover CRPS treatments (including ketamine and bisphosphonates), low-dose naltrexone and PEA, compounded topical options, and pelvic pain/prostatitis approaches including quercetin and antibiotics like fosfomycin when appropriate.

In this wide-ranging Friday episode, Ted and Austin Broer connect the Lindsey Clancy filicide hung jury, electricity costs rising 72% in Washington DC and 50% in California, CoQ10 and omega-3 heart health supplementation, beef price speculation and DOJ investigation, gut health and glyphosate's GHI cleanse correction, aliens and fallen angels in popular culture, Trump's Iran war economic impact and draft recruitment, Firefly fluoride mouthwash children's class action lawsuit, magnesium versus melatonin New York Times comparison, and the Broer Bucks ecosystem development into a broadcast that delivers both urgent health science and sharp cultural, economic, and institutional accountability. 

If you've been hearing more and more about peptide stacks, you've probably come across two names: GLOW and KLOW. And one of the questions I get all the time is, "Which one is better?" But I actually don't think "better" is the right question. The better question is: "What am I trying to accomplish, and which stack makes more sense for that goal?" And the reason is pretty simple. Read the Full Episode Transcript: https://pepties.com/glow-vs-klow-which-one-is-right-for-you/ Related Links/Products Mentioned: Peptide Podcast Partners Page https://pepties.com/partners/ Buy Peptides online at BioLongevity Labs: Use our link and enter COUPON CODE: PEPTIDEPODCAST  at checkout to receive 15% off your total order:  https://go.biolongevitylabs.com/SH5C Momentous Supplements (we use Creatine, Vital Aminos, Whey Protein) https://crrnt.app/MOME/OqGQOxGA LMNT – More Salt, Not Less.  https://elementallabs.refr.cc/default/u/johnjavit Thorne Supplements (we use Omega-3 with CoQ10, Red Yeast Rice, Zinc) https://get.aspr.app/SH1KvW Organifi Creatine and Shilajit Gummies http://rwrd.io/rlbkajm?c MitoZen (methylene blue for Cognitive Function, Anti-Aging, Mental Clarity) https://www.mitozen.com/ref/cnlwiztypt/ For skin and hair health (Copper Tripeptide-1)  Visit Luminose by Entera for an exclusive offer for Peptide Podcast listeners!  ** Promo code PEPTIDEPODCAST at checkout for 10% off an order or 10% off the first month of a subscribe-and-save. ** https://www.enteraskincare.com/?rfsn=8906839.f93c72 NAD+ Push Patch: https://www.pushpatch.com/

Highlights from Dr. Hoffman's vacation.What can my friend take for burning mouth syndrome?I'm looking to build immunity. What are your thoughts on beta-glucans?I hike a lot and want to protect my knees. Would peptides like BPC-157 be of benefit?

What if one tiny carbon molecule could help protect your cells from oxidative stress and support the mitochondria responsible for producing your energy? In this fascinating episode of The Art of Living Well Podcast®, we sit down with Ken Swartz, aka Ken the Scientist, co-founder of C60 Power, to explore Carbon 60 (C60)—a unique form of carbon that Ken first encountered while researching radiation protection in a fusion energy lab. Ken takes us inside the science of C60 and explains why this molecule has gained attention in the longevity and biohacking worlds for its potential role in antioxidant defense, mitochondrial health, cellular energy, inflammation and healthy aging. We break down oxidative stress in simple terms, why mitochondrial function becomes increasingly important as we age, and how C60 differs from familiar antioxidants such as CoQ10 and glutathione. Ken also shares what to look for when choosing a C60 product, including purity, third-party testing, sourcing and packaging. For our midlife listeners, we dig into an especially interesting question: Could supporting mitochondrial health influence the way we experience energy, brain fog and other changes associated with aging? In this episode, you'll learn: What Carbon 60 (C60) actually is—and its surprising connection to fusion-energy research How oxidative stress affects our cells, mitochondria and aging The relationship between mitochondrial function, cellular energy and aging Why brain fog, fatigue and inflammation may be associated with oxidative stress How C60 differs from CoQ10, glutathione and other antioxidants What Ken says about C60 and hormone production—and why women using HRT should discuss supplementation with their healthcare practitioner C60 oil vs. gummies and how the different delivery methods compare What to look for when choosing C60: purity, sourcing, third-party testing and packaging Ways to assess oxidative stress and mitochondrial function What the research does—and does not—tell us about C60 and longevity How topical C60 is being used in skincare Why no supplement replaces the foundations of nutrition, movement, sleep and stress management TIMESTAMPS 00:00 – What is Carbon 60 (C60)? 03:45 – C60, mitochondria and oxidative stress 07:00 – Brain fog, fatigue and inflammation 11:00 – C60, hormones and midlife health 14:30 – How to use C60 and when to expect results 19:45 – How to choose a high-quality C60 product 21:30 – Safety, medications and who should use caution 23:30 – Testing oxidative stress and mitochondrial health 27:30 – C60 for skincare and healthy aging 29:30 – C60 vs. peptides 31:00 – How to get started with C60 Learn more + special listener offer C60 Power: https://shopc60.com Discount code: LIVINGWELL60 C60 research and education: https://www.whatisc60.org ---------------------------------------------------------- Feeling tired, inflamed, or stuck in a cycle of cravings? Join our 7-Day Fall Vitality Reboot starting September 27 and discover how much better you can feel with simple daily habits and a supportive community beside you every step of the way. Click here to save your spot: https://l.bttr.to/fNSbn Not sure where to start, or want to talk it through first? Book a free discovery call with Marnie and Stephanie. Subscribe to our Substack to get episode updates, wellness tips, and personal reflections from Marnie & Stephanie delivered straight to your inbox. Grab your free Midlife Travel Resilience Checklist here. If you love the show and want to support what we're building, consider a paid subscription for $30 annually. https://theartoflivingwell.substack.com/ Follow & Connect: Instagram: https://www.instagram.com/theartofliving_well/ YouTube: https://www.youtube.com/@theartoflivingwellpodcast LinkedIn: https://www.linkedin.com/company/the-art-of-living-well-podcast/ TikTok: https://www.tiktok.com/@theartoflivingwel/ Spotify: https://open.spotify.com/show/4gym3jOPdSHwrpM1BmxyJz Apple Podcasts: https://podcasts.apple.com/us/podcast/the-art-of-living-well-podcast/id1482050468 Connect with Your Hosts:  Marnie Dachis Marmet: https://www.instagram.com/zenfullifecoaching Stephanie May Potter: https://www.instagram.com/stephaniemaypotter/  

The 3 "Longevity Drugs" That Fail the Data, and 4 Repurposed Ones Worth Considering Back with another solo episode, this one on Big Pharma! Metformin, rapamycin, and statins are three of the most trusted names in longevity, and none of them hold up the way you've been told. This episode breaks down the human data behind the drugs everyone assumes are safe, and reveals four lesser-known repurposed pharmaceuticals that might do more for your metabolism, mitochondria, and lifespan. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Dave walks through why metformin blunts the muscle-building signal your body needs from exercise, why rapamycin's stunning mouse studies fell apart in the 2025 PEARL trial, and why statins help one person in a hundred while draining the CoQ10 your mitochondria depend on. Then he lays out the yes list: tadalafil for vascular and brain health, SGLT2 inhibitors for metabolic and kidney protection, acarbose for gut and longevity markers, and low dose naltrexone for calming an overactive immune system. Host Dave Asprey is the father of biohacking, founder of Danger Coffee and Smarter Not Harder, and a New York Times bestselling author who has spent decades studying human performance, functional medicine, and the science of not aging. As co-founder of Unlimited.Life, a concierge longevity practice that runs over $50,000 in lab work per client, he pulls back the curtain on what the data actually shows once you strip away the marketing. This is essential listening for anyone serious about biohacking, longevity, anti-aging, human performance, brain optimization, and hacking their own biology with real supplements and functional medicine tools instead of guesswork. You'll Learn: Why metformin can cancel out the muscle gains from resistance training and drain your B12 for years What the 2025 PEARL trial actually found when rapamycin was tested in healthy adults Why statins carry a 100-to-1 harm-to-benefit ratio and quietly starve your mitochondria of CoQ10 How tadalafil supports nitric oxide, vascular health, and neuroplasticity at low daily doses Why SGLT2 inhibitors trigger ketosis-like metabolic effects and protect kidney function How acarbose changes gut bacteria and shows some of the strongest longevity data in mouse studies How low dose naltrexone modulates the immune system and reduces neuroinflammation How to talk to your doctor about using these drugs off-label for longevity instead of disease treatment Thank you to our sponsors! - ALP | Go to alppouch.com, code DAVE for 10% off. - Timeline | Visit timeline.com/dave and get up to 20% off when you subscribe and save. - Kinetic | Instead of pushing your system harder, Kenetik feeds your brain the ketones it craves to fuel calm clarity and steady focus. Go to drinkkenetik.com/DAVE and use code DAVE for a discount. - Visit www.myvitalc.com/davesfav to unlock Dave's discount Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Metformin, Rapamycin, Statins, Tadalafil, Cialis, SGLT2 inhibitors, Jardiance, Acarbose, low dose naltrexone, longevity drugs, anti-aging medication, repurposed pharmaceuticals, off-label drugs, mTOR inhibitor, AMPK, autophagy, endothelial dysfunction, CoQ10, insulin resistance, mitochondrial efficiency, senescent cells, nitric oxide, neuroinflammation, vascular health, PEARL trial, Unlimited.Life Resources: • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15? • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 01:01 – Intro 03:48 – Metformin 09:18 – Rapamycin 12:55 – Statins 17:28 – Statins & CoQ10 19:38 – Tadalafil 23:43 – SGLT2 Inhibitors 26:12 – Acarbose 28:40 – Low-Dose Naltrexone (LDN) 31:44 – Dosing & Recap See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Neurologist David Perlmutter MD says the beta-amyloid theory of Alzheimer's is wrong — and the real culprit is your brain's own immune cells. In this episode of Health Longevity Secrets, Robert Lufkin MD sits down with the #1 New York Times bestselling author to unpack his new book Brain Defenders: how diet, blood sugar, and metabolic health flip the brain's microglia from protective to destructive, why anti-amyloid drugs offer "trivial" benefit, and which biomarkers actually predict your brain's future.Chapters:00:00 — Introduction01:38 — Why He Left Mainstream Neurology to Prevent Brain Decline05:24 — Building the World's Largest Integrative Neurology Practice06:55 — The Common Pathway From Metabolism to Brain Degeneration08:25 — Why the Beta-Amyloid Theory of Alzheimer's Is Wrong09:11 — What Are Microglia? The Brain's Immune Cells (M1 vs M2)12:13 — From Brain "Glue" to Master Regulators of Your Synapses16:00 — How Body Inflammation and Cytokines Reach the Brain18:15 — Leaky Gut, the Microbiome, and Brain Degeneration19:46 — Ultra-Processed Foods Raise Alzheimer's Risk Up to 270%25:02 — Synaptic Pruning: The Link Between Autism, ADHD and Alzheimer's29:36 — Why Diabetics Recover Worse From Head Trauma31:51 — Anti-Amyloid Drugs: "Trivial" Benefit, Serious Harm35:37 — The Biomarkers to Track: Fasting Glucose, Insulin, A1C40:09 — On the Horizon: Mitochondrial Therapies and Microglial Transplants45:26 — Glyphosate, Air Pollution and 40Hz Light Therapy47:00 — Brain Defenders Releases August 18 — Final TakeawaysKey takeaways:Alzheimer's is increasingly understood as a "synaptopathy" — a disease of lost synapses driven by the brain's own immune cells (microglia), not simply beta-amyloid plaque.Microglia shift from supportive (M2) to destructive (M1) in response to metabolic signals: high blood sugar, insulin resistance, elevated blood pressure, excess body fat, and inflammation.A long-term cohort found each daily serving of ultra-processed food raised Alzheimer's risk ~13%, with 10+ servings/day linked to a 2.7-fold (270%) increase.A Cochrane review of anti-amyloid antibodies found "trivial" cognitive benefit alongside meaningful harm, including brain swelling and microbleeds (ARIA).The most actionable brain biomarkers are cheap and accessible: fasting glucose, fasting insulin, A1c, waist circumference, and a continuous glucose monitor — aim for optimal, not just "normal."Emerging frontiers target the mitochondria inside microglia — metformin, CoQ10, urolithin A, exercise, fasting, ketones, and 40Hz gamma light therapy.Studies & sources:Weinstein et al., J Prev Alzheimers Dis — ultra-processed food and Alzheimer's riskCochrane Review (2026) — anti-amyloid monoclonal antibodies for Alzheimer'sIaccarino, Tsai et al. (Tsai Lab, MIT) — 40Hz gamma light and microgliaDr. Lufkin's book "Lies I Taught in Medical School": https://robertlufkinmd.com/lies/⭐ Enjoying the show? Please leave a 5-star review on Apple Podcasts — it takes 30 seconds and helps more people discover the science of health and longevity. Thank you!New episodes every other Tuesday. Subscribe so you don't miss one.Continue this conversation on Substack: https://robertlufkinmd.substack.comLies I Taught In Medical School — Free sample chapter: https://www.robertlufkinmd.com/lies/Web: https://www.robertlufkinmd.comYouTube: https://www.youtube.com/robertlufkinmdX: https://x.com/robertlufkinmdInstagram: https://www.instagram.com/robertlufkinmd/TikTok: https://www.tiktok.com/@robertlufkinLinkedIn: https://www.linkedin.com/in/robertlufkinmd/

What does a physician-scientist actually do each day to support her own healthy aging? This is a question Dr. Gillian Lockitch hears often. Her answer is not a prescription, a shopping list or a collection of fashionable biohacks. Healthy longevity is personal: our genetics, health histories, medications, priorities and goals differ, so the most useful routine is one designed for the individual. In this solo episode, Dr. Gillian organizes her approach around the seven pillars of healthy longevity described in her book, Growing Older, Living Younger. She explains how epigenetics offers a more hopeful way to think about aging, how food and movement send biological signals, why skin must be treated as an important organ, and how sleep, curiosity, purpose and relationships help protect health and independence. Dr. Gillian also shares her own daily routine—from nutrient-dense foods and time-restricted eating to walking, resistance and balance work, skincare practices and carefully selected supplements. She discusses mitochondrial support, CoQ10, collagen peptides, carotenoid antioxidants, nutrients for bone, joint and eye health, and support for autophagy. She emphasizes that supplements complement beneficial lifestyle habits such as healthy nutrition,  movement, sleep, stress management and where needed, medical care. Her own post-retirement health challenges—including emergency spinal surgery, myopic macular degeneration, and atrial fibrillation have made prevention, resilience and measurement deeply personal concepts. Blood pressure, laboratory testing, bone density, fitness and carotenoid scanning can provide useful feedback, but no single measurement tells the whole story. Her central thesis is simple: do not simply copy someone else's routine. Begin with the fundamentals of your lifestyle, work with healthcare professionals you trust, measure what matters, notice how your body responds, and remain willing to adapt as evidence and circumstances change. Noting that as a retired physician she does not treat or prescribe for medical diseases, she offers one on one conversations on constructing your own Roadmap for Growing Older Living Younger and extending healthspan not just lifespan. A plan for healthy longevity is not a fixed blueprint; it is a lifelong practice developed through curiosity, consistency and purposeful choice and she would love to work with you on your plan.  Episode Timeline 00:11 — Introduction: why Dr. Gillian is sharing her routine—but not prescribing it  03:10 — Pillar 1: Your genes are not your destiny and the promise of epigenetics  06:14 — Pillars 2 and 3: Food is information and movement is medicine  10:00 — Pillars 4 and 5: Caring for skin and nourishing the brain  15:00 — Inside Dr. Gillian's daily healthspan, nutrition and supplement routine  17:59 — Pillars 6 and 7: Lifelong learning, curiosity, connection and community  21:30 — How health challenges reshaped her approach to prevention and resilience  25:00 — Measure what matters: testing, carotenoid scanning and guiding principles  28:40 — Closing invitation: create your own healthy-longevity roadmap with Dr. Lockitch About Dr. Gillian Lockitch  Dr. Gillian Lockitch is a physician, medical biochemist, professor emerita, researcher, international speaker, author and host of the Growing Older Living Younger podcast. After retiring from academic medicine, she began a new chapter in entrepreneurship and healthy-longevity education. Through her book, podcast and Growing Older Living Younger programs, she helps people understand how lifestyle, epigenetics, measurement and purposeful action can support vitality and independence across the lifespan. Dr. Gillian Lockitch is an independent Nu Skin Brand Affiliate. You can join her team as an affiliate ( and build your own business), or a member to buy product or devices at member prices. She may earn a commission from qualifying product purchases. Products and devices mentioned in this podcast reflect her personal routine and are shared for educational purposes only. They are not intended to diagnose, treat, cure or prevent disease, and individual results may vary. She emphasizes  that supplements and skincare devices should complement—not replace appropriate nutrition, movement, sleep or healthcare professionals advice.  Call to Action  Your best healthy-longevity plan is the one designed with you for your lifestyle. Visit askdrgill.com or email askdrgill@gmail.com to begin a conversation about your personal Growing Older Living Younger Roadmap. Subscribe to the podcast, leave a review, and share this episode and the show link with someone ready to invest in extending their healthspan.  Website: www.askdrgill.com  Podcast: Growing Older Living Younger on Apple Podcasts, Spotify and other platforms Join the evolving Growing Older Living Younger Community

When we talk about weight loss, we tend to focus on the number on the scale. How much weight did you lose? How quickly did you lose it? What size are you now? But there is another part of the weight-loss conversation that deserves attention: What is actually happening to your bones? A question I get often is, "Can losing weight cause bone loss?" Or, "Are GLP-1 medications such as semaglutide and tirzepatide harmful to your bones?" Today, we're going to focus on who is most at risk for bone loss during weight loss and, most importantly, what you can do to protect your bones while losing weight. Read the Full Episode Transcript: https://pepties.com/protecting-your-bones-during-weight-loss/ Related Links/Products Mentioned: Peptide Podcast Partners Page https://pepties.com/partners/ Buy Peptides online at BioLongevity Labs: Use our link and enter COUPON CODE: PEPTIDEPODCAST  at checkout to receive 15% off your total order:  https://go.biolongevitylabs.com/SH5C Momentous Supplements (we use Creatine, Vital Aminos, Whey Protein) https://crrnt.app/MOME/OqGQOxGA LMNT – More Salt, Not Less.  https://elementallabs.refr.cc/default/u/johnjavit Thorne Supplements (we use Omega-3 with CoQ10, Red Yeast Rice, Zinc) https://get.aspr.app/SH1KvW Organifi Creatine and Shilajit Gummies http://rwrd.io/rlbkajm?c MitoZen (methylene blue for Cognitive Function, Anti-Aging, Mental Clarity) https://www.mitozen.com/ref/cnlwiztypt/ For skin and hair health (Copper Tripeptide-1)  Visit Luminose by Entera for an exclusive offer for Peptide Podcast listeners!  ** Promo code PEPTIDEPODCAST at checkout for 10% off an order or 10% off the first month of a subscribe-and-save. ** https://www.enteraskincare.com/?rfsn=8906839.f93c72 NAD+ Push Patch: https://www.pushpatch.com/

What if preparing for pregnancy started months before you ever saw a positive test? In this episode of Hormone Genius, Theresa and Jamie dive into the often-overlooked world of preconception health and why preparing your body for pregnancy shouldn't begin after conception—it should begin before. We start with the “fifth vital sign”: your menstrual cycle. Your period, cervical mucus, ovulation, and luteal phase can provide valuable clues about your reproductive health. Learn the three simple things to start watching in your cycle and why understanding your body's natural fertility signs can be such a powerful first step. Then we move beyond the cycle and talk about building a healthy foundation for both women and men, including: • Why giving yourself at least three months to prepare can be valuable • The role of whole foods and the Mediterranean-style approach to nutrition • Key nutrients to consider, including folate, iron, iodine, vitamin D, choline, omega-3s, selenium, and zinc • Why thyroid, metabolic health, hormones, and nutrient status deserve attention • Egg and sperm health—and why the months before conception matter • The potential roles of CoQ10, DHEA, and other targeted approaches for certain individuals • Why your partner's health matters just as much as yours • Sleep, exercise, stress, and environmental exposures • Simple ways to reduce unnecessary exposure to plastics, fragrances, and other household chemicals • Why dental and medication reviews belong on your preconception checklist • What to consider if you've recently stopped hormonal birth control Most importantly, we talk about hope without blame. If you've struggled to conceive, “just relax” isn't helpful—and fertility challenges deserve compassion, understanding, and appropriate care. Medical Disclaimer The information shared in this podcast is intended for educational and informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Every person and pregnancy is unique. Always consult with your qualified healthcare professional regarding your individual health, medications, supplements, fertility, and pregnancy-related questions

A Nobel Prize-winning discovery from 1931 described a cellular “fermentation switch” tied to cancer. That same switch shows up — in a much milder form — in millions of exhausted, foggy, always-cold people who've never had the right tests run.TLDR: Fatigue that sleep doesn't fix. Brain fog. Always cold. Muscle heaviness. Crashing after a workout. These aren't personality traits or “just aging”; they're often signs that your mitochondria, the tiny power plants inside every cell, aren't running the way they should. In this episode, I walk through:* What mitochondria actually do (in plain English)* The 6 physical warning signs your body sends when they're struggling* The 5 lab markers that reveal mitochondrial stress — most of which your standard panel isn't interpreting correctly* Why your body's pH and proton gradient might be the most underrated marker you've never heard of* 8 ways to start rebuilding mitochondrial function this week, starting todayWhat Mitochondria Actually Are (In Plain English)This is a very rudimentary explanation…Every one of your roughly 37 trillion cells contains tiny structures called mitochondria. Their job is to take the food you eat and the oxygen you breathe and convert them into a usable form of energy called ATP (adenosine triphosphate).Think of it like currency exchange. Food is your paycheck. But you can't pay your bills with a paycheck directly. You have to convert it into cash first. That's what mitochondria do. Your heart, brain, and liver cells are packed with hundreds to thousands of them, because those organs demand the most energy.So the real question is: what happens when those mitochondria get damaged?The Warburg Connection And What It Actually Tells UsIn 1931, German biochemist Otto Warburg won the Nobel Prize in Physiology or Medicine for his work on cellular respiration. Part of what made him famous was an earlier observation: many cancer cells generate energy primarily through fermentation (a process called aerobic glycolysis) rather than through the oxygen-based process healthy cells typically rely on - even when plenty of oxygen is available. Warburg's Nobel Prize was officially awarded for his discovery of the respiratory enzyme, and part of what he demonstrated along the way was that cancerous cells can live and develop even in the absence of oxygen. This pattern is now known as the Warburg effect.Here's where I want to be careful, because this is the kind of claim that's easy to oversimplify. It's tempting to say “damaged mitochondria cause cancer,” full stop. The real picture is messier and still debated. Researchers have gone back and forth for decades on whether this metabolic shift is a cause of cancer or a consequence of it, and more importantly, later research found that in most cancers, the mitochondria aren't actually broken. Subsequent research has shown that mitochondrial function is not impaired in most cancer cells, even though those cells still preferentially ferment glucose. The “why” behind that switch remains one of the more actively studied questions in cancer metabolism.So what does this mean for you, a person who almost certainly doesn't have cancer but does feel exhausted all the time? It means the fermentation-under-stress pattern Warburg first described is a real, well-documented phenomenon in cell biology, but I'm not going to tell you that your fatigue is “pre-cancer” or that a milder version of the Warburg effect is definitively what's causing your brain fog. What the broader mitochondrial dysfunction research does support is more modest and, frankly, more useful: when mitochondria are chronically stressed by poor diet, chronic stress, poor sleep, toxin exposure, or simply aging, cells generate less usable energy and more oxidative byproducts, and that shows up in the body long before it shows up on a standard lab panel.The Physical Warning Signs Most Doctors MissI hear a version of this sentence constantly: “My doctor ran labs and everything came back normal.” I believe them - the numbers usually do fall within standard reference ranges. But standard panels weren't built to catch mitochondrial strain. The body, on the other hand, tends to tell you well before a lab does. As you read this list, take honest mental inventory:* Brain fog and poor concentration. Your brain uses roughly 20% of your total energy output despite being about 2% of your body weight, so when brain-cell mitochondria underperform, mental clarity is often the first thing to go.* Fatigue that sleep doesn't fix. Not “I'm tired,” but “I slept eight hours, and I'm still exhausted.” This is one of the most common complaints I hear in practice.* Always feeling cold, or a low body temperature. Body heat is a byproduct of mitochondrial activity, so a consistently low waking temperature (roughly below 97.8°F) can point to a slower metabolic rate.* Muscle weakness or heaviness without a clear cause. Muscle cells are mitochondria-dense and need constant energy for contraction.* Exercise intolerance. You work out, and instead of feeling good afterward, you're wiped out for days without properly recovering.* Sensitivity to light or sound. Sensory processing is energy-expensive, and when cellular energy runs low, the nervous system loses some of its buffering capacity.None of these symptoms are proof of mitochondrial dysfunction on their own; fatigue and brain fog have a long list of possible causes, from thyroid issues to iron deficiency to depression to sleep apnea, and a thorough workup should rule those out first. But if several of these are chronic and unexplained, mitochondrial strain deserves a place on the list.The Lab Markers That Tell the Real StoryThese are markers you can request from a standard blood draw, though a few need to be ordered specifically. I want to flag something important up front: the “optimal” ranges I use in my own practice are tighter than the standard reference range most labs will flag as normal. That's intentional. A value can sit inside the reference range and still not be where I'd want to see it for someone chasing energy and longevity, rather than just ruling out overt disease. That distinction matters, and it's worth discussing with your own physician rather than self-diagnosing off a lab printout.* Fasting insulin. Most labs allow up to 25 µIU/mL as “normal.” I typically look for something closer to 2–5. Insulin creeping up into the high single digits or beyond can be an early sign that cells are struggling to use glucose efficiently.* Fasting glucose. Optimal is generally lower than most people assume, closer to 72–85 mg/dL rather than the upper 90s that many labs will still call normal.* High-sensitivity CRP (hs-CRP). This measures systemic inflammation. Levels of CRP less than 1 mg/L are generally considered low cardiovascular risk, 1 to 3 mg/L moderate risk, and above 3 mg/L elevated risk. Damaged mitochondria leak more free radicals, and that oxidative debris is one of several things that can trigger this kind of low-grade inflammatory signal.* CO2 (bicarbonate). Part of a standard basic metabolic panel, usually reported somewhere in the low-to-high 20s (mEq/L). When it trends toward the lower end, it can be a signal of mild metabolic acidosis; worth flagging and discussing with your doctor rather than a red-alert finding on its own.* Lactate-to-pyruvate ratio. This is a more advanced, specialist-ordered marker. Normally pyruvate flows into the mitochondria and gets converted into usable energy; when mitochondrial function is impaired, pyruvate backs up and converts to lactate instead. It's worth being precise here about what the actual research supports: a lactate-to-pyruvate ratio above 20 has been shown to distinguish patients with primary mitochondrial disease from those with other conditions in clinical studies, and this marker's best-documented use is in diagnosing rare inherited mitochondrial disorders or evaluating critically ill patients not as a general screening tool for everyday fatigue. If you're curious about your own ratio, this is a conversation to have with a clinician who can interpret it in the context of your full picture, not something to self-order and self-interpret.The Proton Gradient: Why pH Might Be an Underrated MarkerHere's a mental picture that helped this concept click for me: imagine Niagara Falls. Water crashes from a height, and that force turns a turbine that generates electricity at the base. Mitochondria do something similar, except instead of water, they're moving protons (hydrogen ions) across a membrane, building up a pressure gradient. When those protons flow back through a molecular structure called ATP synthase, that “turbine” spins and produces ATP.Now imagine you lower the height of the falls. Less force, less electricity. That's roughly what happens when your body's internal environment shifts toward acidity; the proton gradient shrinks, and energy production slows with it.Blood pH is tightly regulated and normally stays between 7.35 and 7.45, it doesn't swing wildly, and if you ever see it trend outside that narrow range on a lab, that's a signal your body's buffering systems are genuinely taxed, not a subtle wellness finding. Because blood pH is so tightly controlled and hard to use as an early, everyday signal, a more practical (though far less precise) proxy some practitioners use is first-morning urine pH, tested with an inexpensive strip. Consistently low first-morning urine pH is sometimes used as a rough indicator that the body is buffering more acid overnight than ideal; though it's a screening tool at best, not a diagnostic one, and it can be influenced by diet, hydration, and other unrelated factors.A quick, honest aside on “structured water.” You may hear claims - including sometimes in wellness spaces I respect - that water inside your cells exists in a special “fourth phase” or “exclusion zone” structure that's central to mitochondrial function, an idea popularized by bioengineer Gerald Pollack. I want to be straight with you about where this stands scientifically: it's a genuinely contested hypothesis, not a fact. Independent researchers have proposed alternative physical explanations for the phenomena Pollack describes, and some of his specific claims - like light-driven charge separation in water - are considered difficult to reconcile with basic physical chemistry. The underlying biology of cellular hydration and mitochondrial function is real and important; the specific “structured water” framework is an interesting but unproven idea layered on top of it, and I don't want to present it to you as settled science.8 Ways to Rebuild Mitochondrial Function (Mitochondrial Biogenesis)The good news is that mitochondria aren't fixed in number or function. Your body can build new ones; a process researchers call mitochondrial biogenesis. Here are eight inputs that support it, roughly in the order I'd actually prioritize them with a patient. Notice that supplements are last, not first.* Morning sunlight. Getting outside within about 30 minutes of waking supports circadian alignment, which in turn supports metabolic function.* Zone 2 cardio. This is exercise intensity where you can still hold a conversation roughly 3–4 sessions per week, 30–45 minutes. It's popularly described as uniquely effective for mitochondrial biogenesis through a signaling pathway called PGC-1α. I want to add a fair caveat here: while Zone 2 has been widely positioned in popular media as the optimal intensity for improving mitochondrial and fatty-acid oxidative capacity, a 2025 narrative review found the evidence for that specific claim is more mixed than commonly portrayed, and some research suggests higher-intensity training activates these same pathways just as strongly, if not more so. Zone 2 is still a well-supported, low-risk, sustainable way to build an aerobic base; I just don't want to oversell it as the only path to mitochondrial adaptation.* Cold exposure. This is a stressor, so I don't recommend starting here if you haven't built a foundation first. In animal studies, chronic cold exposure increases expression of mitochondrial proteins and the master regulator of mitochondrial biogenesis, PGC-1α, in brown adipose tissue - human data on the same mechanism is still developing. However, functional brown fat has been confirmed to exist and activate with cold exposure in adult humans. If you're adapted to it, starting with 30–60 seconds at the end of a shower is a reasonable entry point.* Circadian alignment. Consistent sleep/wake timing supports the same systems that morning light and cold exposure influence.* Structured hydration. Beyond simply drinking more water, this includes grounding and infrared light exposure - inputs that (independent of the more speculative “structured water” claims above) are reasonably tied to circadian and metabolic health.* Metabolic flexibility. This is your body's ability to switch between burning glucose and burning fat for fuel. Time-restricted eating is one of the more accessible tools for improving this, but it's a second-phase intervention, not a starting point, especially if your body isn't metabolically ready for it yet.* Red and near-infrared light therapy. Red to near-infrared light is absorbed by cytochrome c oxidase, an enzyme in the mitochondrial electron transport chain, and this interaction is associated with increased ATP synthesis by mitochondria. Most of the research uses roughly 10–20 minutes of targeted exposure, often over the head and torso.* Mitochondrial cofactors. This is where most people want to start and where I'd ask you to start last. CoQ10, magnesium, and B vitamins (especially B1, B2, B3) function as electron carriers within the Krebs cycle, and alpha-lipoic acid is a mitochondria-specific antioxidant. On top of these, I use Nion to support the body's pH and hydration balance, and Protandim NrF2 to help address the oxidative load that builds up when mitochondria are already under stress, but these work best layered on top of the lifestyle inputs above, not as a substitute for them.Quick Reference: What the Markers MeanThese "optimal" figures reflect the ranges I personally use with patients pursuing proactive metabolic health, not universal diagnostic cutoffs. Always interpret your own labs with a clinician who has your full history.This Week's ProtocolThree simple steps, none of which should cost much or take more than a few minutes a day:* Tomorrow morning: get outside within 30 minutes of waking for a few minutes of natural light.* Pick up pH test strips (inexpensive, available almost anywhere) and test your first-morning urine for three consecutive days. Write the numbers down.* Pull your last basic metabolic panel and find your CO2/bicarbonate value. If you don't have a recent one, get one drawn.Where to Go From HereIf you recognized yourself in several of the symptoms above, the first move isn't panic - it's data. We walk through exactly this kind of cellular assessment with patients every week inside the Thrive 120 framework. If you want a professional to look at your labs and symptom picture and tell you the top three things to address first: Disclaimer: this article is educational, not medical advice. Talk to your doctor before making changes to your diet, exercise routine, or supplement regimen, especially if you're pregnant, nursing, on blood thinners, or managing a chronic condition — including cancer. Some links below are affiliate links — if you buy through them, I may earn a commission at no extra cost to you. These statements have not been evaluated by the FDA, and none of these products are intended to diagnose, treat, cure, or prevent any disease.)References* Nobel Prize in Physiology or Medicine 1931 — Otto Warburg, biographical: https://www.nobelprize.org/prizes/medicine/1931/warburg/biographical/* Warburg effect(s) — a biographical sketch of Otto Warburg and his impacts on tumor metabolism — PMC: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4784299/* Warburg Effect — a Consequence or the Cause of Carcinogenesis? — J Cancer: https://www.jcancer.org/v07p0817.htm* Genome-Scale Metabolic Modeling: mitochondrial function is not impaired in most cancer cells — PMC: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3053319/* C-Reactive Protein and cardiovascular risk categories — Circulation (AHA): https://www.ahajournals.org/doi/10.1161/01.cir.0000093381.57779.67* Clinical usefulness of hs-CRP across Framingham risk scores — Circulation (AHA): https://www.ahajournals.org/doi/10.1161/01.cir.0000125690.80303.a8* Diagnostic values of lactate-to-pyruvate ratio in mitochondrial disease — PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC9334250/* Lactate and lactate:pyruvate ratio in pediatric acute liver failure — PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC5328928/* Mitochondrial dysfunction and ischemia in critical illness (lactate:pyruvate ratio) — PMC: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4470667/* Much Ado About Zone 2: A Narrative Review — PubMed: https://pubmed.ncbi.nlm.nih.gov/40560504/* Chronic cold exposure induces mitochondrial biogenesis in brown adipose tissue — iScience: https://www.cell.com/iscience/fulltext/S2589-0042(21)00402-8* Effect of habitual cold exposure on brown adipose tissue activity — systematic review: https://www.tandfonline.com/doi/full/10.1080/22423982.2025.2545059* Photobiomodulation of cytochrome c oxidase by chronic transcranial laser — PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC8971717/* Brain Photobiomodulation Therapy: A Narrative Review — PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC6041198/* Exclusion Zone Phenomena in Water — A Critical Review of Experimental Findings and Theories: https://arxiv.org/pdf/1909.06822Links mentioned:* Metabolic Blueprint Session: https://calendly.com/tripleplaydoc/complimentary-consult * Nion: https://www.nionhealth.com/tripleplaydoc* Protandim NrF2: https://tripleplaydoc.lifevantage.com/us-en/shop/protandim-nrf2 This is a public episode. 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After performing thousands of open-heart surgeries, Dr. Philip Ovadia recognized that the vast majority were preventable…if his patients had improved their metabolic health in the first place. In this episode, Dr. Chris Motley sat down with heart surgeon, author and podcaster Dr. Philip Ovadia to learn about the underrated relationship between insulin resistance and heart disease, and what you need to know to arm yourself at home and in the doctor's office.  If heart disease has been the number one killer for so long, isn't it possible that we're tackling it the wrong way? Dr. Ovadia's belief is that our emphasis on cholesterol has done us a disservice when it comes to heart health.  If you have a family history of heart issues, or a heart condition yourself, learn how Dr. Ovadia believes you can stay off his operating table.  In this episode you will learn: Why cholesterol and LDLs are not the real enemy of the heart and how sugar is the real culprit when it comes to heart disease.  Why 70 years of cholesterol-focused medicine hasn't reduced heart disease — and what the data actually shows about LDL's role in cardiac events The Craft Test: how Dr. Joseph Craft discovered in the 1970s that 95% of heart disease patients had insulin resistance — compared to only 50% with elevated cholesterol Why your fasting insulin level is the most important number most doctors never order — and how to get it tested for around $10 What exactly to ask your doctor about insulin resistance, and signs and symptoms for it: waist circumference, blood pressure, fasting glucose, HDL cholesterol and triglycerides. How stress plays a role in heart conditions, and how emotional support can make a difference in patients' outcomes. Why statin drugs can be problematic, in that they hide the symptom rather than attacking the root of the problem.  The single question to ask your doctor that will immediately reveal whether they understand metabolic heart disease: "Am I insulin resistant?" Why skin tags, belly fat, rounded face, low energy and high blood pressure are early warning signs of insulin resistance — years before chest pain or shortness of breath appear Dr. Ovadia's recommendations for diet and lifestyle changes to keep you off the operating table: processed food needs to go, and we must move more. If you have a desk-job, try a standing desk or simply get up and move around once an hour.  Meat is medicine. Dr. Ovadia advocates for the nutritional density of meat, yes, even red meat, and suggests that a low-fat diet has not prevented heart disease as promised.  Vitamin K2 and CoQ10 feed the mitochondria our hearts need for energy.  The effects of common viruses like strep on the heart valves. What role genetics plays in heart disease versus habits.  Want more of The Ancient Health Podcast? Subscribe to the YouTube channel. ------  Follow Doctor Motley! Instagram Facebook Website Follow Dr. Philip Ovadia https://www.instagram.com/ifixhearts/ https://ifixhearts.com/team/ https://www.youtube.com/@IFixHearts Buy his books: https://ovadiahearthealth.com/books/ ------  *Head to www.beamminerals.com/DRMOTLEY and enter code DRMOTLEY for 20% off your mineral replenishment order. *Join Doctor Motley's newsletter for TCM insights and regular podcast updates https://www.doctormotley.com/ *Do you have a ton more in-depth questions for Doctor Motley? Check out his course on emotions and the body in his membership. You'll find other courses full of his expertise and clinical wisdom, plus bring all your questions to his weekly lives! To try risk-free for 15 days click here https://www.doctormotley.com/15

Being diagnosed with cancer at a young age can feel incredibly isolating. While your peers may be building careers, starting families, and planning for the future, suddenly you're navigating treatment decisions, fertility concerns, relationships, finances, and fears you never expected to face. In this episode of the Wellness Warriors Podcast, De'Ann sits down with Dr. Christina Pozo-Kaderman, Senior Psychologist at Dana-Farber Cancer Institute and co-author of Coping with Cancer in Early Adulthood, to explore the unique challenges young adults face during and after cancer. Drawing from more than 35 years of experience, Dr. Pozo-Kaderman shares insights on finding support, advocating for yourself, fertility and sexual health, and family-focused care. She also shares a special gift for listeners: free copies of Coping with Cancer in Early Adulthood for those who need one. You can connect with her through the Dana-Farber Young Adult Program to learn more. And as you support your body through a demanding healing journey, cellular energy matters too. Nano CoQ10, available in the Breast Cancer Conqueror shop, provides CoQ10 to support mitochondrial energy production and antioxidant defenses, making it a simple addition to a personalized wellness routine. Shop Nano CoQ10  

Cell Signaling, Mitochondria & the Foundation of Cellular Health with Dr. Gus VickeryWhat if the reason you feel tired, foggy, inflamed, or simply not quite like yourself begins much deeper than you think—at the level of your cells?In this episode of The Healthy CEO, Jason Wright welcomes back physician and Authentic Health co-founder Dr. Gus Vickery for a deep dive into one of the most fundamental—and often overlooked—components of health: cell signaling.Our cells aren't isolated little machines. They're constantly communicating with one another, responding to nutrients, hormones, inflammation, stress, toxins, the nervous system, and even our thoughts and environment. When those signals are clear and the cellular machinery is functioning properly, the body can adapt and perform remarkably well.But when those signaling pathways become disrupted, the effects can show up everywhere.Dr. Vickery explains how impaired cellular function can manifest as fatigue, brain fog, inflammation, anxiety, poor sleep, reduced cognitive performance, aches and pains, and diminished energy—sometimes long before someone develops a diagnosable disease.Jason and Gus also explore the crucial role of the mitochondria, the energy-producing structures inside our cells. Using the analogy of a car and its engine, they break down why mitochondrial efficiency isn't simply about producing more energy. The health and integrity of mitochondrial membranes can profoundly influence how effectively that energy-production system operates.The conversation then moves to another overlooked part of cellular health: the cell membrane.Rather than simply being a protective wall around a cell, the membrane is an active participant in communication and signaling. Its composition—including omega-3 fatty acids, phospholipids and other nutrients—can influence membrane fluidity, inflammatory signaling and cellular function.Dr. Vickery explains how testing can reveal imbalances in membrane composition, including low omega-3 levels, elevated saturated fats and deficiencies in important phospholipids. He also discusses why lifestyle and environmental factors appear to play such an important role in mitochondrial dysfunction, even when genetics influence an individual's underlying resilience.The episode concludes with the origin story behind Authentic Health's F2 formulation. Gus explains how years of clinical experience led him from simply supplementing omega-3s to thinking more comprehensively about phospholipids, fat-soluble nutrients, CoQ10 and the other components necessary to support membrane and mitochondrial health.The result was an attempt to simplify what had previously required numerous individual supplements into a more integrated foundational approach.In This EpisodeWhat cell signaling actually means and why it mattersHow cells communicate within tissues and throughout the bodyWhy disrupted signaling may appear as fatigue, brain fog, inflammation and poor moodThe difference between dysfunction and diseaseWhy mitochondrial dysfunction can occur before diagnosable diseaseThe "car engine" analogy for understanding mitochondrial healthWhy mitochondrial membranes are critical to energy productionHow damaged or dysfunctional membranes may reduce mitochondrial efficiencyWhy the cell membrane is much more than a protective shellUnderstanding membrane fluidityThe role of omega-3 fatty acids, including EPA and DHAWhy phospholipids such as phosphatidylcholine matterHow saturated fats and fatty-acid composition affect membrane structureGenetics vs. lifestyle in mitochondrial dysfunctionHow Dr. Vickery evaluates mitochondrial and cellular healthThe difference between conventional primary care and a more integrative diagnostic approachWhy nutrient insufficiency can exist even before obvious deficiency or diseaseThe importance of reducing harmful exposures while restoring essential nutrientsHow Gus's clinical protocol evolved into the F2 essential fats formulationWhy rebuilding cellular and mitochondrial health should be viewed as a long-term process rather than a quick fixKey TakeawayHealth doesn't begin with treating disease. It begins with giving the body what it needs to communicate, produce energy, repair itself and adapt appropriately.As Dr. Vickery explains, dysfunction can exist long before a physician can put a diagnostic label on it. Addressing foundational cellular health earlier may offer an opportunity to support better function before dysfunction becomes more deeply established.And that means thinking beyond symptoms and asking a more fundamental question:What do my cells actually need to function the way they were designed to function?About Dr. Gus VickeryDr. Gus Vickery is a physician with decades of clinical experience whose work has evolved from traditional primary care toward an integrative, precision-health approach focused on understanding and addressing the underlying drivers of dysfunction.His clinical experience and research into nutrient status, mitochondrial biology and cellular membrane health also informed the development of the Authentic Health foundational formulations discussed in this episode.Learn MoreTo learn more about the Authentic Health foundational products discussed during the episode, visit shopauthentichealth.com.The content provided in The Healthy CEO is for informational and educational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always consult your physician or another qualified healthcare provider before making changes to your health routine.

You've probably heard that your ovaries age 2.5x times faster than the rest of your body. I went looking for that study. It does not exist. In this episode I trace that number back to an uncited supplement company blog post, and then I give you the one that is real: ovarian aging shows up 15 to 20 years earlier than in any other tissue in your body. Your ovaries are not a fertility organ. They are the organ that sets the pace for your bones, your heart, your brain and how long you live. This is the first episode built on my four pillars: Nourish, Stack, Live and Align. I also share what is changing behind the scenes, including my practice, my planner, and where this brand is going next. Work with me one on one as a women's longevity practitioner and holistic nutritionist: https://biohackingbrittany.com/pages/clients WHAT I COVER The 2.5x ovarian aging myth and where it actually came from Why the Stanford organ aging clocks never included an ovary Senescence and fibrosis: it is not that the seeds run out, it is that the soil goes hard Why less than 2 percent of venture funding goes to women's health, and 90 percent of that goes to fertility Your full lab panel: AMH by age, antral follicle count, day 3 FSH and estradiol Why AMH does not predict whether you will get pregnant this month The birth control trap: if you are on hormonal contraception your AMH is wrong by 14 to 55 percent PMOS and why a high AMH is not extra time Cysts: functional, hemorrhagic, dermoids, and why the pill does not shrink one you already have Endometriomas, and what cystectomy actually costs your ovarian reserve Premature ovarian insufficiency, the 2024 criteria change, and why POI is not early menopause What the food research does and does not support CoQ10, melatonin, inositol, DHEA, vitamin D, NMN and omega 3, ranked by real human evidence Rapamycin, the VIBRANT trial, and ovarian tissue freezing The pelvic bowl in the classical Sanskrit text, and what it actually describes Jing, Tian Gui, and how Chinese medicine predicted the end of fertility at 49 How misalignment shows up in the body, and the guardrail I insist on Why clinical hypnosis is the woo that actually works TIMESTAMPS 08:03 The 2.5x ovarian aging myth, and what is actually true 13:23 Your ovaries are an endocrine organ, not a fertility organ 19:54 The labs to run, and AMH by age 23:55 If you are on birth control, your AMH is wrong 28:03 Cysts, dermoids, and what the pill does not do 32:24 Endometriomas and what surgery costs your ovarian reserve 34:20 Premature ovarian insufficiency 36:43 Nourish and Stack: food, CoQ10, melatonin, inositol, NMN 47:06 Rapamycin and ovarian tissue freezing 49:22 Align: the pelvic bowl, Chinese medicine, and how misalignment shows up 1:00:18 Clinical hypnosis, and my full protocol MENTIONED IN THIS EPISODE 1:1 client consults: https://biohackingbrittany.com/pages/clients The LongHer Life community, where this was recorded live: https://biohackingbrittany.com/pages/longherlife Her Stack Planner: https://biohackingbrittany.com/products/her-stack-planner Shop: https://biohackingbrittany.com/collections/shop Questions for the next live Q&A: info@biohackingbrittany.com CONNECT Instagram: https://www.instagram.com/biohackingbrittany/ Website: https://biohackingbrittany.com This episode is for education only and is not medical advice.

Unbreakable: A Woman's Guide to Aging with Power A clear, science-backed roadmap to building strength, supporting your body, and taking control of how you age. Get your copy: https://www.theunbreakablelifestyle.com/unbreakable-book We feel the fatigue, yet we push through anyway, telling ourselves the exhaustion is just part of getting older. But that midlife tiredness is often something deeper.  Today we talk about the third time bomb of aging,  mitochondrial dysfunction, and why your cellular power plants hold the key to your energy, your metabolism, and your longevity. Here's what most women never hear: when you stop demanding energy from your body, it stops building the engines that create it. Weak, dysfunctional mitochondria pollute your cells and quietly fuel inflammation and insulin resistance. The good news is that you can reverse the trend. I'll show you how to trigger biogenesis and mitophagy through movement, precision nutrition, and hormonal optimization, so you can rebuild your cellular power and stop accepting exhaustion as the price of getting older. What we cover: - Midlife fatigue: why it's a mitochondrial crisis, not just poor sleep - ATP production: how mitochondria fuel your heart, brain, and muscles - Sedentary living: how inactivity stops new mitochondria from forming - Cellular pollution: how weak mitochondria drive inflammation and insulin resistance - Biogenesis and mitophagy: building new engines and clearing damaged ones - Muscle and movement: how aerobic exercise engineers cellular power - Nutrition and supplements: omega-3s, antioxidants, B vitamins, CoQ10, and creatine for ATP - Hormonal optimization: how estrogen and thyroid protect mitochondrial function  

Today we're going to compare the two available forms of semaglutide: the once-weekly injection and the once-daily tablet. Both contain semaglutide, but they differ significantly in how the medication is absorbed, how often it's taken, the instructions for administration, approved uses, storage requirements, and cost. We'll also discuss the technology that makes oral semaglutide possible, why the tablet has specific timing requirements, and which option may be a better fit depending on your health history and lifestyle. Read the Full Episode Transcript: https://pepties.com/semaglutide-injection-vs-tablet-which-one-is-right-for-you/ Related Links/Products Mentioned: Peptide Podcast Partners Page https://pepties.com/partners/ Buy Peptides online at BioLongevity Labs: Use our link and enter COUPON CODE: PEPTIDEPODCAST  at checkout to receive 15% off your total order:  https://go.biolongevitylabs.com/SH5C Momentous Supplements (we use Creatine, Vital Aminos, Whey Protein) https://crrnt.app/MOME/OqGQOxGA LMNT – More Salt, Not Less.  https://elementallabs.refr.cc/default/u/johnjavit Thorne Supplements (we use Omega-3 with CoQ10, Red Yeast Rice, Zinc) https://get.aspr.app/SH1KvW Organifi Creatine and Shilajit Gummies http://rwrd.io/rlbkajm?c MitoZen (methylene blue for Cognitive Function, Anti-Aging, Mental Clarity) https://www.mitozen.com/ref/cnlwiztypt/ For skin and hair health (Copper Tripeptide-1)  Visit Luminose by Entera for an exclusive offer for Peptide Podcast listeners!  ** Promo code PEPTIDEPODCAST at checkout for 10% off an order or 10% off the first month of a subscribe-and-save. ** https://www.enteraskincare.com/?rfsn=8906839.f93c72 NAD+ Push Patch: https://www.pushpatch.com/

Failed IVF? Low AMH? High FSH? Told donor eggs? Book a free Functional Fertility Second Opinion before your next fertility decision → fabfertile.com Your cycle was cancelled on day eight or day nine. Someone called and said there were not enough follicles and it was not worth going ahead. At the follow up, you heard the words poor responder. What do you actually do with that? Change the protocol. Go again next month. Take three months off and work on your health. Get another opinion. Or accept that this is what your ovaries are capable of and stop looking for an explanation. This is where I see women get stuck, because if you are listening to this, you have already done a lot. Clean eating, the supplements, CoQ10, a methylfolate prenatal, vitamin D, no alcohol, no plastics, acupuncture twice a week, reading It Starts With The Egg. Almost nobody walks into IVF blindly. None of that answers the question in front of you now. What should I actually do before another retrieval? In this episode, I walk through the three questions I would want answered. None of them are more supplements, and none of them are another checklist. A cancelled cycle tells you how your ovaries responded to medication. It was never designed to tell you about the environment those eggs were developing in during the ninety days before the injections started. What I cover: what the cycle actually established and what it was never built to answer. What happened in those ninety days, including the full thyroid panel with antibodies rather than TSH alone, ferritin where we look at 80 to 100, high sensitivity CRP where we like it below one, and absorption. Your partner's side, including DNA fragmentation, sperm antibodies and the seminal microbiome across his seventy-four days. And the question to ask your fertility team before you agree to another retrieval: what exactly are we changing, and why? I am not telling you which protocol to be on. That is a conversation with your fertility team. I am also not saying any one of these markers explains a cancelled cycle. That is not the claim I am making. It is about whether the investigation was finished before the next decision. CHAPTERS 00:00 Your cycle was cancelled and you heard poor responder 01:00 Question one, what did the cycle actually tell us 02:00 Everything you had already done before the cycle 03:00 Question two, what happened in the ninety days before stimulation 04:00 Full thyroid panel, ferritin, high sensitivity CRP and absorption 05:00 His side, DNA fragmentation, and why this is personal for me 06:00 What Your Clinic Missed, and what we actually look at 07:00 Question three, if you go again, what will be different 08:00 The Functional Fertility Second Opinion 09:00 Closing WHAT YOUR CLINIC MISSED A list of markers worth reviewing before another IVF cycle or a donor egg decision. It also gives you a sense of what we look at with clients, beyond bloodwork. Email hello@fabfertile.ca, subject line MISSED, and we will send you the guide. FUNCTIONAL FERTILITY SECOND OPINION A free 45-minute call where I review your bloodwork, your history, and your partner's results with you. Bring your partner and load your labs before the call. Email hello@fabfertile.ca, subject line FERTILE, or book here. ABOUT THE HOST I'm Sarah Clark, founder of Fab Fertile and host of Get Pregnant Naturally, a podcast with over one million downloads. My functional fertility team works with couples navigating low AMH and failed IVF, reviewing functional lab results, gut microbiome, food sensitivity, vaginal microbiome, nutrigenomics, HTMA, DUTCH, toxin testing, and bloodwork alongside nervous system work, to help identify patterns that may not have been considered. We work alongside your medical team, not instead of them. Sarah Clark, founder of Fab Fertile, host of Get Pregnant Naturally (1M+ downloads), and author of Fabulously Fertile. If this episode helped, leave a review on Apple Podcasts. It is how other women find this work.

If you’ve spent years being told that endometriosis is “just bad periods” or that the pill will fix it, this episode is going to reframe everything.Endometriosis affects 1 in 10 women and takes an average of 7 to 10 years to diagnose. But what most doctors never tell their patients is that endo is not simply a hormonal imbalance. Research has confirmed it is an autoimmune condition, characterized by impaired natural killer cell function, T-regulatory cell dysfunction, and chronically elevated inflammatory cytokines. It is also a mitochondrial disease — with measurable dysfunction in the energy-producing machinery inside every cell. In this deep-dive episode, Dr. Deb covers: Why oral contraceptives do not treat endo — and how they systematically deplete CoQ10, magnesium, B vitamins, and raise SHBG in ways that can persist long after stopping the pill Why oral estrogen is the wrong HRT choice for women with endo history and what the research actually says about transdermal delivery The truth about hormone allergies — a real, documented, and profoundly underdiagnosed immune condition that Dr. Deb’s clinic is one of only three in the country treating How Low-Dose Immunotherapy (LDI) can restore immune tolerance to your own hormones A comprehensive integrative toolkit: evidence-supported supplements, botanicals, and investigational peptides that address endo at its actual biological roots How to do bioidentical HRT safely and intelligently with an endo history This is the episode every woman with endo or suspected endo needs to hear. Connect with us:Website: https://www.letstalkwellness.comInstagram: https://www.instagram.com/letstalk_wellnessnow/Facebook: https://www.facebook.com/LetsTalkWellnessNowPodcastLinkedIn: https://www.linkedin.com/company/lets-talk-wellness-now/ Subscribe to Let’s Talk Wellness Now so you never miss an episode, and if this one opened your eyes, share it with someone who needs to hear it.The post Episode 278: The Endo Truth: Why Your Immune System, Your Hormones, and Your Mitochondria Are All in a Fight—And How to Finally Win first appeared on Let's Talk Wellness Now.

Question?

In this episode the guys break down the best machines for every body part — the legendary Hammer Strength H Squat for legs, the old school Nautilus pullover for back, the Smith machine upright row and Viking press for shoulders, the FreeMotion multi-plane chest fly, the high elbow seated curl machine for biceps, the seated skull crusher machine for triceps, and the hip thrust machine for glutes. They also tell the wild true story of a Soviet doctor who performed his own appendectomy in Antarctica in 1961, get into the trainer-client event they hosted and why it was their most emotional one yet, discuss the science and health benefits of forgiveness and what the data shows about holding grudges, share the story from Les Miserables about grace and how it transforms a person, talk PDE5 inhibitors and their anti-cancer properties, and go deep on probiotics as the next major performance supplement. Then they coach live callers submitted through mplivecaller.com.   Mind Pump Fitness Coaching: https://mindpumpfitnesscoaching.com 1.9 NASM CEUs   SPONSORS   Dose for Your Liver: https://dosedaily.co/MINDPUMP Code: MINDPUMP35 for 35% off first month subscription. 95% of participants reported a positive impact on LDL levels in their clinical study. Natural ingredients: amla fruit, pomegranate, ginger, turmeric, CoQ10, lycopene, niacin and folate.   Seed Daily Synbiotic: https://seed.com/mindpump Code: 25MINDPUMP for 25% off your first month. Probiotics discussed extensively on air — emerging data on fat loss, strength gains and athletic performance.   Butcher Box: https://butcherbox.com/mindpump No code needed. Free ribeyes, NY strip steaks or filet mignons in every order for a year plus $20 off first box.   LINKS   Submit a live caller question: https://mplivecaller.com Mind Pump Store: https://mindpumpstore.com Maps Fitness Products: https://mapsfitnessproducts.com Instagram: @mindpumpmedia   0:00 - Intro 2:10 - Best machines for every body part — the ones worth using if you see them 3:52 - Legs: Hammer Strength H Squat (leg-a-saurus) — why bodybuilders still talk about it 5:42 - Back: Nautilus pullover — why Joe DeFranco still raves about it 10:13 - Shoulders: Smith machine upright row, Viking press and standing lateral machine 12:36 - Chest: FreeMotion multi-plane fly — best range of motion of any chest machine 13:47 - Biceps: High elbow seated curl machine — the position you can't replicate with free weights 14:41 - Triceps: Seated skull crusher machine — go light and feel everything 16:05 - Glutes: Hip thrust machine — why this beats the barbell version for most people 18:02 - The Soviet doctor who performed his own appendectomy in Antarctica in 1961 27:27 - Probiotics as the next major performance supplement — fat loss, strength and endurance data 32:34 - The trainer-client event — why it was their most emotional one yet 44:06 - Dose for liver and cholesterol — 95% LDL improvement in clinical study 51:13 - The science of forgiveness — what holding a grudge actually does to your body 57:03 - Les Miserables and grace — the story Sal wants everyone to watch 1:08:37 - Caller: Kaylee (Arizona) — getting married November 11th, Hashimoto's, wants to look her best 1:17:04 - Caller: Olivia (Toronto) — burned out after 7 years, 911 dispatcher training to be a firefighter 1:30:34 - Caller: Alana (New Jersey) — disheartening DEXA scan after a cut, history of restrictive eating 1:48:00 - Caller: Joey (Tennessee) — rotating shift worker, two young kids, testosterone at 164  

Let's kick things off by answering the big question: What exactly is KPV? KPV is a small peptide consisting of just three amino acids, lysine-proline-valine. It's a fragment of the larger peptide alpha-melanocyte-stimulating hormone (α-MSH), which is involved in skin pigmentation and immune function. KPV is naturally found in the body and is known for its anti-inflammatory properties, but it has a more specific action on inflammation-related pathways that contribute to various health conditions. This peptide has been gaining popularity due to its potential in reducing inflammation, improving skin health, and supporting overall wellness, particularly in individuals with chronic conditions. Read the Full Episode Transcript: https://pepties.com/kpv-benefits/ Related Links/Products Mentioned: Peptide Podcast Partners Page https://pepties.com/partners/ Buy Peptides online at BioLongevity Labs: Use our link and enter COUPON CODE: PEPTIDEPODCAST  at checkout to receive 15% off your total order:  https://go.biolongevitylabs.com/SH5C Momentous Supplements (we use Creatine, Vital Aminos, Whey Protein) https://crrnt.app/MOME/OqGQOxGA LMNT – More Salt, Not Less.  https://elementallabs.refr.cc/default/u/johnjavit Thorne Supplements (we use Omega-3 with CoQ10, Red Yeast Rice, Zinc) https://get.aspr.app/SH1KvW Organifi Creatine and Shilajit Gummies http://rwrd.io/rlbkajm?c MitoZen (methylene blue for Cognitive Function, Anti-Aging, Mental Clarity) https://www.mitozen.com/ref/cnlwiztypt/ For skin and hair health (Copper Tripeptide-1)  Visit Luminose by Entera for an exclusive offer for Peptide Podcast listeners!  ** Promo code PEPTIDEPODCAST at checkout for 10% off an order or 10% off the first month of a subscribe-and-save. ** https://www.enteraskincare.com/?rfsn=8906839.f93c72 NAD+ Push Patch: https://www.pushpatch.com/

In this episode of the Health Optimization Medicine Podcast, Dr. Scott Sherr, Dr. Ted Achacoso, Dr. Allen Bookatz, and Jodi Duval explore one of the most overlooked causes of declining cellular energy: the structural breakdown of the mitochondrial membrane. While many people invest in premium longevity supplements like NAD+, NMN, and CoQ10 to improve energy production, emerging research suggests these compounds cannot overcome a damaged mitochondrial membrane. The team explains how age-related phosphatidylcholine depletion weakens the mitochondrial lipid bilayer, causing proton leakage, oxidative stress, and reduced ATP production, even when the biochemical machinery appears intact. From membrane lipidomics and clinical metabolomics to phosphatidylcholine replacement and methylation support, this discussion reframes mitochondrial health through the lens of structural integrity rather than simply adding more fuel. Join us as we delve into: The Leaky Mitochondria Problem: Why declining phosphatidylcholine causes proton leaks that reduce ATP production and accelerate mitochondrial aging. Why NAD+, NMN & CoQ10 Sometimes Fail: How expensive mitochondrial supplements cannot restore energy when the mitochondrial membrane itself has become structurally compromised. Pathogenesis vs. Salutogenesis: Why Health Optimization Medicine focuses on building the biology of health instead of simply preventing disease. Clinical Metabolomics & Membrane Lipidomics: How measuring functional biomarkers provides deeper insight into cellular health than conventional blood tests alone. Phosphatidylcholine Replacement Therapy: Why rebuilding mitochondrial membranes with pharmaceutical-grade phosphatidylcholine, methyl donors, and chronobiology may improve bioenergetics. The Prevention Paradigm Shift: Why optimizing membrane integrity may become a foundational strategy for supporting healthy aging and cellular resilience. This episode is for you if: You are taking NAD+, NMN, CoQ10, or other mitochondrial supplements but still struggle with fatigue or poor recovery. You want to understand why mitochondrial membrane health may be more important than simply increasing energy substrates. You are interested in clinical metabolomics, membrane lipidomics, and the future of precision lifestyle medicine. You want to learn how phosphatidylcholine and methylation support contribute to healthy mitochondrial function. You can also find this episode on… YouTube: Find more from Health Optimization Medicine and Practice (HOMeHOPe): Website: https://homehope.org/ Instagram: https://www.instagram.com/homehopeorg/ HOMeHOPe Conference 2026: https://homehope.org/homehope-conference-2026 Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics Find more from Troscriptions: Website: https://troscriptions.com/ Instagram: https://www.instagram.com/troscriptions/ Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products

If you would like to learn more about the show, please feel free to visit our website at Foreveryoungradio.com   where you can listen to past shows and read fantastic articles including The Glutathione Theory of Aging.  Written by our very special guest.Dr. Ross Pelton is a pharmacist, clinical nutritionist, health educator, and the author of 12 books. In October 1999, Ross was named one of the Top 50 Most Influential Pharmacists in America by American Druggist Magazine for his work in natural medicine. Ross is also The Natural Pharmacist. His personal website, bio & blog are at: naturalpharmacist.net.Dr. Pelton joins us today to discuss CoQ10. What it is, why we need it, and the clinical research surrounding it.If you want to make sure you get the benefits from a daily supplement of CoQ10 why not choose the original formulation that has been used in the most important scientific studies to document the effects of CoQ10?-Proven best in test with three times better absorption*-With more than 30 years of research.-Clinically documented in more than 78 human scientific studies.Article on the science and many key benefits on how people can benefit when supplementing with the correct form of Coq10.Save 20% OFF your first order with the code NP10 at Pharmanord.comLearn more about Dr. Ross Pelton

Episode 2874 - In this wide-ranging Monday episode, Ted and Austin Broer connect statins' documented CoQ10 depletion and cardiac consequences, GLP-1 drugs' hair loss and muscle wastage effects, magnesium's role in mental health and brain chemical regulation, the adolescent mental health crisis driven by poor sleep and social media, Hawaii's emergency order allowing pharmacists to administer COVID vaccines to children without parental consent, Greenland's rare earth mineral strategic importance, and China's dominance of global rare earth reserves into a broadcast that delivers both urgent health science and sharp geopolitical and institutional accountability.

First, let's break down what BPC-157 actually is. BPC stands for Body Protection Compound, and the 157 refers to the specific amino acid sequence that makes up this peptide. It's a synthetic peptide derived from a protein found in our stomach, specifically in gastric juice. This peptide has been shown to have a range of healing properties, particularly related to tissues like the gut, muscles, and tendons. The reason BPC-157 is getting attention in the realm of acid reflux and gastrointestinal issues is because of its potent regenerative abilities. Some studies suggest it could promote healing in the gastrointestinal tract, reduce inflammation, and improve the gut barrier—key factors for people dealing with acid reflux. Read the Full Episode Transcript: https://pepties.com/acid-reflux-relief-with-bpc/ Related Links/Products Mentioned: Peptide Podcast Partners Page https://pepties.com/partners/ Buy Peptides online at BioLongevity Labs: Use our link and enter COUPON CODE: PEPTIDEPODCAST  at checkout to receive 15% off your total order:  https://go.biolongevitylabs.com/SH5C Momentous Supplements (we use Creatine, Vital Aminos, Whey Protein) https://crrnt.app/MOME/OqGQOxGA LMNT – More Salt, Not Less.  https://elementallabs.refr.cc/default/u/johnjavit Thorne Supplements (we use Omega-3 with CoQ10, Red Yeast Rice, Zinc) https://get.aspr.app/SH1KvW Organifi Creatine and Shilajit Gummies http://rwrd.io/rlbkajm?c MitoZen (methylene blue for Cognitive Function, Anti-Aging, Mental Clarity) https://www.mitozen.com/ref/cnlwiztypt/ For skin and hair health (Copper Tripeptide-1)  Visit Luminose by Entera for an exclusive offer for Peptide Podcast listeners!  ** Promo code PEPTIDEPODCAST at checkout for 10% off an order or 10% off the first month of a subscribe-and-save. ** https://www.enteraskincare.com/?rfsn=8906839.f93c72 NAD+ Push Patch: https://www.pushpatch.com/

Episode 2871 - In this wide-ranging Wednesday episode, Ted and Austin Broer connect the gut-brain axis and autism microbiome research, Himalayan salt's documented immune cancer-fighting enhancement, chronic inflammation's dietary root causes, CoQ10's depletion by statins and cardiovascular benefits, Ford's self-driving vehicle repossession patent, Aaron Rodgers' CNN Fauci criticism, whey protein quality and New Zealand sourcing, Florida's constitutional drag show children ban, and a restraining order hearing involving satanic threats into a broadcast that delivers both urgent health science and sharp institutional and cultural accountability.

On this episode of Vitality Radio, Jared shares the story behind the long-awaited return of the Ultimate Vitality Multi and explains why this is the most significant reformulation in the product's history. After addressing the unexpected supply delays, he walks through every major upgrade, including the addition of PQQ and CoQ10 for mitochondrial support, clinically relevant lutein and zeaxanthin for eye health, expanded metabolic support with chromium and vanadium, enhanced detoxification ingredients, higher potency adaptogens, and improved nutrient forms throughout the formula. Jared also explains the philosophy behind creating a three-capsule daily multivitamin that prioritizes meaningful ingredient forms and potencies while remaining an exceptional value. If you've ever wondered what separates a premium multivitamin from an ordinary one, this episode is for you. Products:NEW & IMPROVED Ultimate Vitality MultiAdditional Information:655: Behind the Label: What cGMP, NSF & Third-Party Testing Really Tell You346: The Ultimate Vitality Multi - What Makes It the Ultimate Multivitamin for YouVisit the podcast website here: VitalityRadio.comYou can follow @vitalitynutritionbountiful and @vitalityradio on Instagram, or Vitality Radio and Vitality Nutrition on Facebook. Join us also in the Vitality Radio Podcast Listener Community on Facebook. Shop the products that Jared mentions at vitalitynutrition.com. Let us know your thoughts about this episode using the hashtag #vitalityradio and please rate and review us on Apple Podcasts. Thank you!Just a reminder that this podcast is for educational purposes only. The FDA has not evaluated the podcast. The information is not intended to diagnose, treat, cure, or prevent any disease. The advice given is not intended to replace the advice of your medical professional.This podcast is produced by DrTalks.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://drtalks.com/podcast-service/⁠

What can you actually do to support your egg quality before your next IVF cycle? I'm honored to share this s episode of IVF In Your Pocket, hosted by Alexandra Geary-Stock where we go over  my whole-body approach to egg quality, from supplements and rapamycin to red light therapy, ovarian PRP, and yes, even EDM music. Whether you're just starting to try to conceive or gearing up for your next embryo transfer, I think you'll loave this episode because we're talking about practical, accessible steps you can start today. In this episode, we cover: Dr. Aimee's head-to-toe framework for supporting egg quality (mental health, sleep, nutrition, relationships, uterine health, exercise) Why "support" egg quality is a better mindset than "improve" it Reducing microplastic exposure in everyday products Her go-to supplement stack: OVA NAD+ and CoQ10 (and why less is more) Using rapamycin as an anti-aging aid for egg quality Peptides, growth hormone, and GLP-1 for body inflammation Red light therapy and ovarian PRP explained Dr. Aimee's top 5 accessible tips to support egg quality Resources: Read the full show notes on Dr. Aimee's website Find Alexandra Geary-Stock's therapy practice and podcast (IVF in Your Pocket) here. Do you have questions about IVF? Click here to join Dr. Aimee for The IVF Class. The next live class call is on Monday, August 17th at 4pm PST, where Dr. Aimee will explain IVF and there will be time to ask her your questions live on Zoom. Dr. Aimee Eyvazzadeh is one of America's most well known fertility doctors. Her success rate at baby-making is what gives future parents hope when all hope is lost. She pioneered the TUSHY Method and BALLS Method to decrease your time to pregnancy. Learn more about the TUSHY Method and find a wealth of fertility resources at www.draimee.org. Other ways to connect with Dr. Aimee and The Egg Whisperer Show: Subscribe to my YouTube channel for more fertility tips!Subscribe to the newsletter to get updates Related Phrases egg quality, supporting egg quality, IVF tips, Dr. Aimee, Egg Whisperer, fertility doctor, OVA NAD, CoQ10, rapamycin, egg quality supplements, ovarian PRP, red light therapy, peptides for fertility, GLP-1 fertility, NAD infusions, microplastics fertility, embryo quality, euploid embryo, IVF cycle prep, trying to conceive tips

What Are the Key “Ins” and “Outs” for Living a Healthier, Longer Life? In this episode of Live Foreverish, Dr. Mike and Dr. Crystal explore three health "ins" and one "out." They discuss curcumin's anti-inflammatory benefits for benign prostatic hyperplasia, CoQ10's role in improving cholesterol, blood sugar, and energy metabolism in metabolic disorders, and bone broth's nutritional value for gut health. For the "out," they warn against PFAS exposure during pregnancy, linking it to adverse fetal development, and offer practical tips to minimize exposure through water filtration and avoiding certain cookware and food packaging. #LELEARN #EDULFsocial

What Are the Key “Ins” and “Outs” for Living a Healthier, Longer Life? In this episode of Live Foreverish, Dr. Mike and Dr. Crystal explore three health "ins" and one "out." They discuss curcumin's anti-inflammatory benefits for benign prostatic hyperplasia, CoQ10's role in improving cholesterol, blood sugar, and energy metabolism in metabolic disorders, and bone broth's nutritional value for gut health. For the "out," they warn against PFAS exposure during pregnancy, linking it to adverse fetal development, and offer practical tips to minimize exposure through water filtration and avoiding certain cookware and food packaging. #LELEARN #EDULFsocial Guest Bio: Katarzyna Maresz, PhD, is the former president of the International Science and Health Foundation and former Scientific Coordinator of the educational portal VitaminK2.org. She is currently the Executive Coordinator of the Vitamin K2 Scientific Advisory Committee, a group of independent experts. She collaborates with academic and industry partners worldwide on projects related to vitamin K2, bone health, cardiovascular health, and other emerging areas.

Today, we're talking about a hot topic in the world of fitness and wellness: peptide stacking. Whether you're looking to build lean muscle, burn fat, enhance recovery, or boost cognitive function, peptide stacking could be a game-changer. But, just like anything, it's important to know the ins and outs of how it works and how to "stack" safely. Read the Full Episode Transcript: https://pepties.com/stacking-peptides/ Related Links/Products Mentioned: Peptide Podcast Partners Page https://pepties.com/partners/ Buy Peptides online at BioLongevity Labs: Use our link and enter COUPON CODE: PEPTIDEPODCAST  at checkout to receive 15% off your total order:  https://go.biolongevitylabs.com/SH5C Momentous Supplements (we use Creatine, Vital Aminos, Whey Protein) https://crrnt.app/MOME/OqGQOxGA LMNT – More Salt, Not Less.  https://elementallabs.refr.cc/default/u/johnjavit Thorne Supplements (we use Omega-3 with CoQ10, Red Yeast Rice, Zinc) https://get.aspr.app/SH1KvW Organifi Creatine and Shilajit Gummies http://rwrd.io/rlbkajm?c MitoZen (methylene blue for Cognitive Function, Anti-Aging, Mental Clarity) https://www.mitozen.com/ref/cnlwiztypt/ For skin and hair health (Copper Tripeptide-1)  Visit Luminose by Entera for an exclusive offer for Peptide Podcast listeners!  ** Promo code PEPTIDEPODCAST at checkout for 10% off an order or 10% off the first month of a subscribe-and-save. ** https://www.enteraskincare.com/?rfsn=8906839.f93c72 NAD+ Push Patch: https://www.pushpatch.com/

Dr. Balcavage's new book, Is This The Hill?, releases at the end of July. Get on the waitlist to receive updates, exclusive bonus content, and early announcements at drericbalcavage.com/hill. Just because a supplement is designed to support mitochondrial function doesn't mean it's supportive for your body right now. In this final episode of Dr. Eric's mitochondrial series, he explores one of the biggest misconceptions in functional medicine: assuming that low mitochondrial function automatically means you need more mitochondrial support. Many people are told they have "mitochondrial dysfunction" based on lab testing and immediately begin taking supplements like CoQ10, carnitine, B vitamins, NAD precursors, methylene blue, or additional thyroid hormone. While these interventions can absolutely be helpful in the right situation, they aren't always addressing the real problem. Dr. Eric explains why mitochondria often reduce energy production as an adaptive response—not because they're broken, but because the body is responding to stress, inflammation, immune activation, poor oxygen delivery, under-fueling, or other protective signals. You'll learn why temporarily feeling better on a supplement doesn't necessarily mean you've corrected the underlying issue, and why increasing energy production without first restoring your body's capacity can actually create more stress over time. Instead of asking, "What supplement do I need?" Dr. Eric encourages you to ask a much more important question: Why are my mitochondria behaving this way in the first place? In this episode, you'll learn: Why mitochondrial support isn't always supportive The difference between increasing energy production and restoring resilience Why low mitochondrial output doesn't automatically mean deficiency How mitochondrial testing can identify patterns without explaining the underlying cause Why supplements may help temporarily but fail to produce lasting recovery How thyroid hormone, B vitamins, CoQ10, carnitine, and other "energy" supplements can increase demand on the body Why your physiologic state determines whether an intervention will help or create additional stress The importance of restoring capacity before trying to optimize mitochondrial function How State-Based Medicine™ approaches mitochondrial dysfunction differently If you've been told you have mitochondrial dysfunction, poor T4-to-T3 conversion, or low energy despite trying countless supplements, this episode will give you a new framework for understanding what's really happening—and why creating the right conditions for recovery is often more important than forcing more energy production. Need help understanding your symptoms? If you've been struggling with fatigue, thyroid symptoms, or chronic health issues despite trying multiple treatment approaches, schedule a complimentary Discovery Call to learn whether Dr. Eric's State-Based Medicine™ approach may be right for you.

I answer questions submitted by listeners about topics ranging from how to ensure great sleep after nighttime exercise, effective no-caffeine pre-workouts (that also improve your sleep quality), neuroscience-supported tools for improving your memory and sense of smell, nutrition and supplementation for improving female and male fertility, the link between (peri)menopause and mental health, accelerating recovery from surgery, how to find your life's passion, and more. Please note that if your question was not answered this time, we will keep it to consider for future Q&A episodes. A special thank you to everyone who submitted a question! Read the episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Eight Sleep: https://eightsleep.com/huberman BetterHelp: https://betterhelp.com/huberman LMNT: https://drinklmnt.com/huberman Timestamps (00:00:00) Your Questions Answered (00:01:42) Late-Day Training & Pre-Workout, Cortisol; Tools: Alpha-GPC, Garlic & TMAO, Hot Shower, Physiological Sigh, Post-Workout Food (00:13:57) Sponsors: Eight Sleep & BetterHelp (00:16:12) Morning Daylight, East vs West Facing, Melanopsin Cells; Tool: Ambient Daylight, Prior Light History (00:22:54) Over-Optimization & Protocol Overwhelm, Core Pillars, Consistency, Resentment, Alcohol (00:33:32) Sponsor: AG1 (00:34:48) Memory, Hippocampus & Neocortex, Exercise & Arousal, Errors, Sleep, Tool: Self-Testing; Sense of Smell, Tool: Sniff Training, Anosmia (00:53:11) Fertility & Nutrition, Body Fat, Testosterone Therapy, HCG & Sperm; Low-Inflammation Diet, Fermented Foods, CoQ10, L-Carnitine (01:08:24) Sponsor: LMNT (01:09:46) Perimenopause & Menopause, Anxiety, Hormone Therapy, Sleep (01:18:08) Sunrise vs Sunset Wedding, Chronotypes (01:22:52) Kidney Donation & Surgery Recovery; Tools: Prehabilitation, Circadian Rhythm in the Hospital; Muscle Memory (01:30:57) Careers in Science (01:32:05) Finding Your Passion, Structure & Work, “No Input, No Output”; Tool: Chop Wood, Carry Water (01:43:49) Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

Diets rich in fruits and vegetables preserve brain function—but in vulnerable persons with the ApoE4 “Alzheimer's gene”, more meat staves off decline, contradicting years of recommendations to minimize animal protein; Supplements for adrenal insufficiency; “Forever chemicals” may weaken teen's bones—but menopausal hormone replacement therapy decisively fends off osteoporosis; Legionnaire's disease strikes poor and affluent alike in New York City; Doctors propose warning labels for GLP-1 drugs on account of this under-appreciated danger.

Can you prevent preeclampsia? In this deep dive, we look at the root causes, proposed mechanisms, and holistic support strategies for one of the most serious complications of pregnancy. We are learning more about what may contribute to preeclampsia, including placental development, inflammation, oxidative stress, mitochondrial dysfunction, endothelial health, genetics, nutrient status, paternal factors, the microbiome, environmental toxins, and long-term cardiovascular risk.Aspirin is one of the most recommended prevention tools, and in this episode we get into why it is used, what it actually does, and where its benefits seem strongest. But it turns out, there may be a lot more to the prevention conversation.In this episode, we cover:What preeclampsia is and how it is diagnosedThe two-stage model of preeclampsia: abnormal placental development and maternal vascular dysfunctionOxidative stress, inflammation, mitochondrial dysfunction, platelet activation, and endothelial healthGenetic factors: MTHFR, homocysteine, methylation issuesEpigenetics: how lifestyle may influence gene expression in pregnancyEnvironmental toxins, including BPA, phthalates, PFAS, heavy metals, air pollution, and placental healthThe paternal factor: semen exposure, paternal antigens, sperm health, obesity, and immune toleranceGut, vaginal, oral, and urinary microbiome researchCOVID infection, COVID vaccination data, and preeclampsia riskWhy preeclampsia is linked to future cardiovascular diseaseWhat the evidence actually says about baby aspirinSupplements that may help with prevention: Calcium, vitamin D, magnesium, lycopene, omega-3s, CoQ10, NAC, and moreNutrition: the DASH diet, Mediterranean diet, fiber, probiotics, and food-first nutrition strategiesExercise in pregnancy and what we know about hypertensive disordersSleep, obstructive sleep apnea, and preeclampsia riskMind-body medicine, stress physiology, mindfulness, yoga, acupuncture, and blood pressure regulationHow to think about prevention without fear, blame, or over-supplementingThe full episode transcript with citations for all studies mentioned can be found at: drmaryellawood.com

Join The Circle (use code PODCAST): ➡️ https://holplus.co/circle/Why are you always tired, even after getting enough sleep? If you wake up exhausted, struggle with brain fog, rely on caffeine, or lose your energy halfway through the day, the problem may begin inside your cells.In this solo episode of hol+, Dr. Taz explains why your body may be “biologically bankrupt,” meaning it is using energy faster than it can rebuild it. She breaks down three hidden causes of low energy: mitochondria that are not producing enough power, declining NAD levels, and old “zombie cells” that remain in the body and increase inflammation.You'll also learn simple ways to support your energy, including better sleep, moderate exercise, stress management, intermittent fasting, and nutrients such as magnesium, B vitamins, CoQ10, and quercetin.In this episode:Why you may still feel tired after sleepingHow your cells create energyThe connection between fatigue and brain fogWhat mitochondrial dysfunction meansWhy NAD matters for energy and cellular repairWhat “zombie cells” areHow inflammation drains your energyWhy caffeine and sugar only provide a temporary boostHow sleep and exercise help rebuild cellular energyPractical ways to stop running on emptyLearn more about hol+ and schedule an appointment:https://holplus.co/Listen to more episodes of the hol+ podcast:https://holplus.co/podcast/If you know someone who is always tired or struggling with low energy, share this episode with them. Subscribe for new episodes about hormones, gut health, inflammation, healthy aging, and whole-person healing every week.Stay Connected:Dr. Taz: https://www.instagram.com/drtazmd/Hol+: https://www.instagram.com/liveholplus/Hol+ Show: https://www.instagram.com/holplushow/Subscribe to the audio podcast: https://holplus.transistor.fm/subscribeSubscribe to the video podcast: https://www.youtube.com/@HolPlusShow/podcastsGet your copy of ➡️ The Hormone ShiftChapters00:00 Why Your Energy Never Seems to Last00:48 Chi, Prana and the Body's Energy01:49 Why Our Cells Are Running on Empty02:54 What Is Biological Bankruptcy?04:01 The 3 Pillars of Cellular Energy05:08 How Mitochondria Produce Energy06:24 Oxidative Stress and Mitochondrial Damage07:39 How Mitochondrial Dysfunction Accelerates Aging08:29 Chronic Fatigue, Long COVID and Cellular Energy09:48 Your Fatigue Has an Address10:14 Join The Circle11:00 Why NAD Is Essential for Cellular Repair11:44 Why NAD Levels Decline12:13 The NAD and Inflammation Cycle13:41 What Are Senescent or “Zombie” Cells?15:22 How Zombie Cells Drive Inflammaging15:57 What Fatigue May Reveal About Your Health16:35 Cellular Energy, Focus and ADHD17:24 How to Reverse Biological Bankruptcy17:46 Sleep and Mitochondrial Repair18:15 Exercise and Mitochondrial Renewal18:41 CoQ10, Magnesium and B Vitamins19:04 Rebuilding NAD Levels19:39 How to Clear Out Zombie Cells19:59 Intermittent Fasting and Autophagy20:13 Cortisol and Mitochondrial Dysfunction21:02 Final TakeawaysProduced by https://ClipGrowth.com (Producer: Pat Gostek)

Send us Fan MailSupplements are one of the most common topics my patients ask about... and one of the most misunderstood.Do you really need a multivitamin? What about vitamin D, magnesium, omega-3s, probiotics, creatine, collagen, CoQ10, or B12? Are they all necessary—or are some just expensive extras?In this episode, I break down the science behind the most commonly used supplements, including:✔️ Who may benefit✔️ When to check your levels✔️ How to choose safe, high-quality supplements✔️ What to avoid✔️ And when a supplement may not be necessary at allMost importantly, we'll talk about the truth that every patient needs to hear:Supplements are meant to supplement a healthy lifestyle—not replace it.No pill can take the place of nutritious food, regular movement, quality sleep, stress management, and healthy daily habits. That's where true wellness begins.If you've ever stood in the supplement aisle wondering what to buy—or have a cabinet full of vitamins you're not sure you even need—this episode is for you.

Local doctor Dr. Terry Wahls is back on the show. This time, she joins us to share her recent clinical trials in a two-part series.  Today, in Part 1, she shares her miraculous story, and we discuss dietary and lifestyle approaches for autoimmune conditions. Next week, in Part 2, she will share more about her clinical trials and explain how she lives her life currently, maintaining her high-functioning health. Foods necessary for overcoming autoimmune conditions: Leafy green vegetables, like spinach, Swiss chard, kale, and collards Deeply colored fruits and vegetables, like carrots, beets, and berries Sulfur-rich foods, including the cabbage family and mushrooms Protein sources, like meat, fish, and poultry (Or beans, legumes, and gluten-free grains like rice or buckwheat for vegetarians) Fermented foods like sauerkraut, kimchi, and kefir Organ meats like liver once a week Dr. Terry Wahls's Bio: Dr. Terry Wahls is an Institute for Functional Medicine Certified Practitioner and conducts clinical research using functional medicine principles in the setting of multiple sclerosis.  In 2018, she was awarded the Institute for Functional Medicine's Linus Pauling Award for her contributions in research, clinical care, and patient advocacy.  Dr.Wahls has secondary progressive multiple sclerosis, which confined her to a tilt-recline wheelchair for four years.  Yet Dr.Wahls restored her health using a diet and lifestyle program she designed specifically for her brain, and now pedals her bike to work each day.  She is the author of The Wahls Protocol: How I Beat Progressive MS Using Paleo Principles and Functional Medicine, The Wahls Protocol: A Radical New Way to Treat All Chronic Autoimmune Conditions Using Paleo Principles (paperback), and the cookbook The Wahls Protocol Cooking for Life: The Revolutionary Modern Paleo Plan to Treat All Chronic Autoimmune Conditions. In this episode: How electrical stimulation therapy allowed Dr.Wahls to feel great despite her physical limitations (3:56) How redesigning her diet and adding the right supplements improved her multiple sclerosis symptoms and increased her strength and mobility (4:18) Foods that are necessary for improving brain health and overcoming autoimmune diseases (13:55) How Dr.Wahls helped veterans reverse type 2 diabetes, obesity, and autoimmune diseases through diet and lifestyle changes (18:05) How Dr. Wahls got banned from speaking at a conference after sharing about using lifestyle and diet to manage MS (19:39) The importance of a healthy diet and quality nutrition for maintaining good health (25:34) Links and Resources: Use CODE OMEGA3 to get 10% off ⁠OMEGA3 FISH OIL⁠ Use CODE BERBERINE to get 10% off ⁠Berberine⁠ Use code COQ10 to get 10% off ⁠COQ10⁠ Follow Your Longevity Blueprint  On ⁠Instagram⁠ | ⁠Facebook⁠ | ⁠Twitter⁠ | ⁠YouTube⁠ | ⁠LinkedIn⁠ ⁠Get your copy of the Your Longevity Blueprint book and claim your bonuses here⁠ ⁠Find Dr. Stephanie Gray and Your Longevity Blueprint online⁠   Follow Dr. Stephanie Gray  on ⁠Facebook⁠ | ⁠Instagram⁠ | ⁠Youtube⁠ | ⁠Twitter⁠ | ⁠LinkedIn⁠ ⁠Integrative Health and Hormone Clinic⁠ ⁠Podcast production by Team Podcast⁠  Guest Social Media Links: ⁠Facebook⁠ ⁠Instagram⁠ ⁠Twitter⁠ ⁠YouTube⁠ ⁠Clinical Trial⁠ 

Dr. Catharine Arnston is an expert on algae nutrition, a wellness thought leader, an experienced entrepreneur and sought after speaker. In 2008 Catharine left her corporate job to care for her sister who was diagnosed with breast cancer. When Catharine learned that algae's vast healing properties were documented in tens of thousands of scientific studies, but none of these studies or benefits were known outside of Asia, she knew she had to do something. And that's how ENERGYbits was born! In this episode, Dr. Catharine Arnston and Tara dive into how spirulina and chlorella microalgae power mitochondria, detox the body, support gut health, and plug into biohacking and women's longevity.   RESOURCES: Learn more about ENERGYbits and use code COACHTARA for 20% off: http://www.energybits.com  Instagram: @energybits Get 10% off Peluva minimalist shoe with coupon code COACHTARA here: http://peluva.com/coachtara Enjoy the previous conversation with Dr. Catharine Arnston here: https://www.taragarrison.com/blog/catharinearnston3    CHAPTERS: 00:03 – Catharine Arnston returns to the show 00:32 – Catharine's algae journey and ENERGYbits origin story 02:36 – Sponsor: Peluva barefoot shoes ad 04:22 – Why Catharine is a favorite educator 04:55 – Macroalgae vs microalgae basics 05:40 – Spirulina vs chlorella: fiber and nutrient density 06:05 – UN, NASA, and microalgae's extreme protein content 07:01 – How ENERGYbits algae is farmed and why Taiwan matters 07:43 – Drying process, heat, and preserving SOD in spirulina 08:42 – Microalgae overview and the dominance of spirulina/chlorella 09:21 – Pigments: chlorophyll vs phycocyanin and methylene blue 10:27 – Phycocyanin, cancer pathways, and chemo applications 10:53 – Spirulina and chlorella do "night and day" different jobs 11:24 – Spirulina history and Catharine's book "Love Your Health to Bits" 12:20 – How spirulina gives clean energy without sugar or caffeine 13:10 – Amino acid "Legos," protein absorption, and bioavailability 14:11 – B vitamins, ATP, and steady log‑on‑the‑fire energy analogy 18:59 – Mitochondria protection, regeneration, and long‑term energy 19:18 – SOD2 genetics, toxin load, and mast cell/energy issues 43:03 – Chlorella, microbiome, colon health, and motility analogies 45:01 – Chlorella as gut health, fiber, liver support, and PM algae 46:20 – Using spirulina and chlorella daily, fasting, and electrolytes 46:33 – Stacking algae with sauna, cold plunge, and red light 47:23 – Red light + chlorophyll + CoQ10 for ATP and inflammation 49:00 – Travel, sachets, tins, and biohacking with algae in real life 51:50 – Algae as foundational "food" alongside sleep, light, movement 52:16 – Why Catharine insists algae is food, not a supplement 52:29 – Tara's generalized "what should I take" answer: ENERGYbits 53:26 – Labs, targeted supplements, and algae as safe "for everyone" 63:01 – Catharine's millennial team, stamina, and protecting what you have 64:03 – Vision: spirulina/chlorella on the food pyramid for daily use 1:04:34 – Book title, presale, and upcoming audiobook details 1:11:56 – Where to find more, ratings, reviews, and sign‑off   WORK WITH TARA: Are You Looking for Help on Your Wellness Journey? Here's how Tara can help you: TRY TARA'S APP FOR FREE: http://taragarrison.com/app INDIVIDUAL ONLINE COACHING: https://www.taragarrison.com/work-with-me CHECK OUT HIGHER RETREATS: https://www.taragarrison.com/retreats   SOCIAL MEDIA:  Instagram @coachtaragarrison TikTok @coachtaragarrison Facebook @coachtaragarrison Pinterest @coachtaragarrison   INSIDE OUT HEALTH PODCAST SPECIAL OFFERS: ☑️ Upgraded Formulas Hair Test Kit Special Offer: https://bit.ly/3YdMn4Z ☑️ Upgraded Formulas - Get 15% OFF Everything with Coupon Code INSIDEOUT15: https://upgradedformulas.com/INSIDEOUT15 ☑️ Rep Provisions: Vote for the future of food with your dollar! And enjoy a 15% discount while you're at it with Coupon Code COACHTARA: https://bit.ly/3dD4ZSv   If you loved this episode, please leave a review! Here's how to do it on Apple Podcasts: Go to Inside Out Health Podcast page: https://podcasts.apple.com/us/podcast/inside-out-health-with-coach-tara-garrison/id1468368093 Scroll down to the 'Ratings & Reviews' section. Tap 'Write a Review' (you may be prompted to log in with your Apple ID). Thank you!

Your Hormones Are Killing You: Oxytocin, FSH, and the Anti-Aging Protocol Most Doctors Ignore Your hormones are running your love life, your intuition, your longevity, and your brain, and most doctors are getting it completely wrong. Host Dave Asprey sits down with triple board-certified OBGYN Dr. Anna Cabeca to break down the clinical science of oxytocin, female pleasure, hormonal optimization, and why fixing your hormones can make your 70s the best decade of your marriage. Dr. Anna Cabeca is a triple board-certified OBGYN and fellow of gynecology and obstetrics, integrative medicine, and anti-aging and regenerative medicine, with additional board certifications in functional medicine, sexual health, and bioidentical hormone replacement therapy. She is the bestselling author of The Hormone Fix, Keto-Green 16, and MenuPause, and has spent decades researching the clinical intersection of oxytocin, cortisol, estrogen, and progesterone on women's hormonal health, metabolism, and longevity. Her work on keto-green nutrition, vaginal and bladder microbiome health, and bioidentical hormone replacement has made her one of the most credentialed and clinically experienced voices in women's functional medicine practicing today. Dave and Dr. Anna break down the real pharmacology of oxytocin, including its role in muscle regeneration, cortisol suppression, mitochondrial signaling, and vagal tone optimization. They expose the toxic ingredients hiding in mainstream lubricants and vaginal hormone creams, including aspartame, parabens, and petroleum derivatives, and explain why the vaginal microbiome is a frontline organ for women's metabolism and anti-aging. They get into the neuroscience of orgasm, pineal gland activation, endogenous DMT release, and the neurochemical cascade behind peak altered states. Dr. Anna also breaks down the Women's Health Initiative disaster, the FDA's recent reversal on bioidentical hormone replacement, and why FSH is a critical and widely overlooked longevity biomarker. High post-menopausal FSH drives neuroinflammation, accelerates bone loss, and degrades brain optimization outcomes, and most physicians are not testing for it. This is essential listening for anyone serious about biohacking, longevity, anti-aging, functional medicine, human performance, brain optimization, and taking full ownership of their biology. You'll Learn: Why oxytocin functions as a regenerative hormone that rebuilds muscle, suppresses cortisol, and supports mitochondria signaling What toxic chemicals are hiding in standard lubricants and vaginal hormone creams and what to use instead How orgasm activates the pineal gland and triggers endogenous DMT release and altered neurological states Why female intuition may be directly linked to mitochondrial density concentrated in the ovaries How elevated FSH drives neuroinflammation, bone loss, and accelerated brain aging in post-menopausal women Why the FDA reversed 30 years of flawed guidance on bioidentical hormone replacement therapy How four days of sensory deprivation supercharges melatonin, oxytocin, and endogenous DMT production Why oxytocin combined with ketamine is being used clinically to break trauma patterns and rewire neural pathways How polyphenols, CoQ10, carnitine, and vagal tone training protect cardiovascular health and support longevity Why polypharma accelerates decline and what functional medicine does differently Thank you to our sponsors! - KILLSwitch | If you're ready for the best sleep of your life, order now at https://www.switchsupplements.com/and use code DAVE for 20% off - Gatlan | Book your free consultation at www.gatlan.com/DAVE - Redmond Real - Leaf Toothpaste | Go to https://redmond.com/asprey and use code ASPREY for 15% off your first order. - Neuronic | Go to www.neuronic.online Code DAVE for $100 off Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Dr. Anna Cabeca, The Girlfriend Doctor, oxytocin, bioidentical hormone replacement, FSH, follicle-stimulating hormone, vaginal microbiome, Velve lubricant, Julva, Mighty Maca, cortisol suppression, pineal gland, DMT, neuroinflammation, broken heart syndrome, NT-proBNP, vagal tone, dark retreat, orgasmic meditation, Women's Health Initiative, perimenopause, postmenopause, yoni massage, oxytocin nasal spray, cabergoline, prolactin, Pitocin, CoQ10, carnitine, Arterosil, polypharma, keto-green, The Hormone Fix Resources: • Get An Exclusive Offer On Dr. Anna's Products At: dranna.com/tribe • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 01:37 – What Is Oxytocin? 07:38 – Clean Lube Launch 09:11 – Toxic Lube Ingredients 17:08 – Oxytocin Prescribing 18:58 – FDA Reverses HRT Warning 26:50 – Dark Retreat & DMT 32:15 – Orgasmic Meditation 42:06 – Female Intuition 46:21 – Broken Heart Syndrome 51:15 – FSH & Hormone Monitoring See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Episode Highlights With KatieWhy the traditional biochemical model of the body is incomplete...and why the body is electric firstThe shocking amount of energy your body generates each day (about your own body weight in ATP!)Why 90–95% of chronic diseases have mitochondrial dysfunction at the rootHow your mitochondria act not just as powerhouses but as quantum batteries, antennas, and information hubsThe surprising sources of electrons that create cellular voltage...including sunlight, melanin, movement, structured water, and the earth itselfHow infrared light charges your “quantum battery,” while artificial blue light breaks it downWhy hydration with minerals is essential for building cellular charge (and why plain water can ake things worse)The nutrients mitochondria require to function: phospholipids, healthy fats, CoQ10, copper, B-vitamins, carnitine, creatine, and moreWhat redox really means and why redox balance must come before detoxHow a collapse in redox leads to the Cell Danger Response, chronic symptoms, and stalled healingThe many ways modern life drains voltage: lack of sunlight, EMFs, stress, toxins, blue light, poor sleep, dehydration, and circadian disruptionSimple daily strategies to restore voltage...starting with light, minerals, movement, grounding, and sleepHow tools like red/near-infrared light, PEMF, BioCharger, sauna, cold therapy, Juvent, and vibration plates support mitochondrial energyResources MentionedRed light therapyPEMF matBioChargerSaunasPower Plate vibration plateCold plungeJuventJustine ClassThe Body ElectricDr courtney hunt insta and websiteYour spark is light classMineral podcast seriesWater structure pitcher affiliate linkRebounder on amazon

Try TrueDark glasses: https://truedark.comTry Danger Coffee: https://dangercoffee.com/Try Suppgrade Labs: https://shopsuppgradelabs.com/Over the last 15 years, I've built companies and spent millions testing what actually upgrades human performance, and I can tell you that mental fatigue has absolutely nothing to do with willpower. In this video, I break down the exact neurochemistry of deep focus. When your brain runs out of dopamine, norepinephrine, and acetylcholine, or gets bogged down by oxidative stress, your executive function collapses. The pharmaceutical industry wants you hooked on expensive stimulants that only treat the symptoms, but the real biological fix is a common antioxidant: Vitamin C.I explain how your brain hoards Vitamin C at levels 100 times higher than your blood, how to bypass the blood-brain barrier using SVCT2 transporters, and why eating sugar before you take it completely blocks its absorption. You'll also learn the exact biohacking stack—including NAC, CoQ10, PQQ, and L-theanine—you need to recycle this molecule, protect your mitochondria, and maintain effortless, razor-sharp focus all day long.Thank you to our sponsors!-KILLSwitch | If you're ready for the best sleep of your life, order now at https://www.switchsupplements.com/and use code DAVE for 20% off-Viome | Check it out at viome.com and use code 10DAVE for 10% off. It's time to stop guessing and start knowing your body.-iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVETimestamps:00:00 – Trailer00:21 – Focus Is Biology01:53 – Brain Chemistry Explained05:33 – Vitamin C Revealed07:09 – How to Dose08:18 – Absorption Barriers09:31 – Optimize Uptake10:00 – Oxidative Stress Problem11:00 – Stack for Deeper FocusConnect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/Danger Coffee: https://dangercoffee.com/DAVE15Dave Asprey's BEYOND Conference: https://beyondconference.com/Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15Upgrade Labs: https://upgradelabs.com40 Years of Zen: https://40yearsofzen.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

How to Reverse Cognitive Decline, Grow Your Hippocampus, and Protect Your Brain from Alzheimer's Disease with Nutrition, Exercise, Sleep, and Stress Reduction Your brain is physically shrinking right now, and most people have no idea it's happening. In this episode, you will discover the exact mechanisms behind cognitive decline, why brain fog is always treatable, and the proven strategies to grow your brain back, protect your memory, and slash your Alzheimer's risk regardless of your genetics. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Dr. Majid Fotuhi, a neuroscientist and neurologist who earned his PhD from Johns Hopkins University and his medical degree from Harvard Medical School. He currently serves as an adjunct professor at the Mind/Brain Institute at Johns Hopkins while also teaching at George Washington University and Harvard Medical School. With 37 years of experience in clinical practice, teaching, and neuroscience research, Dr. Fotuhi pioneered the Brain Fitness Program, a multidisciplinary approach to cognitive performance and brain vitality at any age that has produced measurable results documented in peer-reviewed journals. He is the author of three books including the bestselling The Invincible Brain and one of the world's leading experts on neuroplasticity, hippocampus growth, and successful aging. If anyone has earned the right to tell you your brain can get better, it is him. Dr. Fotuhi and Dave break down why Alzheimer's is not a single disease but a soup of modifiable problems, why your lab results can show "normal" while your brain is starving, and how the five pillars of brain health connect directly to longevity, mitochondria function, and human performance. They also get into the brain effects of GLP-1s, the therapeutic promise of psychedelics like psilocybin and ketamine, the role of nootropics and supplements like B12, lithium orotate, and CoQ10, and why your VO2 max may be the single most important number for brain aging. . You'll Learn: Why 97% of Alzheimer's cases involve multiple modifiable causes and what to do about each one How to physically grow your hippocampus through exercise, meditation, and nutrition Why "normal" lab ranges are actively harming millions of people and what optimal actually looks like The 7 everyday things that are shrinking your brain right now How stress, loneliness, and isolation cause measurable brain atrophy Which supplements including B12, lithium orotate, CoQ10, and nootropics support long-term brain health Why VO2 max predicts brain aging better than almost any other marker What psychedelics like psilocybin and ketamine actually do to your brain according to a Johns Hopkins neurologist How the APOE4 gene affects Alzheimer's risk and why exercise can erase that risk entirely Why mitochondria health is the foundation of both brain function and longevity Thank you to our sponsors! - Viome | Check it out at viome.com and use code 10DAVE for 10% off. It's time to stop guessing and start knowing your body. - BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle. - Pique | Go to Piquelife.com/dave for 20% off. - BodyHealth | Visit BodyHeath.com and use code DAVE20 for 20% off your first purchase Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Majid Fotuhi, Dr. Majid Fotuhi, The Invincible Brain, brain health, cognitive decline, Alzheimer's prevention, hippocampus, neuroplasticity, brain fog, memory loss, APOE4, brain shrinkage, B12 deficiency, lithium orotate, CoQ10, nootropics, VO2 max, mitochondria, longevity, anti-aging, biohacking, brain optimization, sleep optimization, stress reduction, functional medicine, human performance, psilocybin, ketamine, GLP-1, semaglutide, telomeres, BDNF, brain training, cognitive performance Resources: • Learn More About Dr. Fotuhi's Work At: https://drfotuhi.com/ • Purchase Dr. Fotuhi's New Book The Invincible Brain: https://a.co/d/0iHCgPpL • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 00:59 – Intro 03:00 – Cannabis & Nicotine 04:15 – Understanding Alzheimer's 05:38 – Five Pillars Explained 07:55 – Best Cognitive Training 09:08 – Brain Size & Growth 12:36 – B12 & Lab Ranges 17:48 – Head-to-Toe Evaluation 24:17 – Sex & Brain Health 25:43 – Loneliness & Isolation 33:59 – ApoE4 Genetics 35:28 – Alzheimer's Declining 48:44 – Lithium & Brain 59:38 – VO2 Max & Fitness 1:06:42 – Psychedelics 1:09:38 – GLP-1s & Brain 1:12:38 – Closing & Action Steps See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.