Podcasts about DHA

I mange år har fett blitt delt inn i to enkle kategorier: sunt og usunt. Men hva om det bare er en liten del av historien? Hva om de ulike fettsyrene har helt forskjellige oppgaver i kroppen og er avgjørende for alt fra cellemembraner og immunforsvar til hjernen, hormonene og stoffskiftet?Professor emeritus Jan Raa er tilbake i Leger om livet. Som biolog, mikrobiolog og en av Norges fremste pionerer innen biomarin forskning har han brukt flere tiår på å forstå hvordan fett påvirker menneskets biologi, helt ned på cellenivå.Vi snakker blant annet om:Hva fett og fettsyrer egentlig er – og hvorfor de er blant kroppens viktigste byggesteinerForskjellen på omega-3, omega-6 og omega-9 – og hvorfor de har ulike biologiske funksjonerHvorfor ALA, EPA, DHA og DPA ikke er det sammeHvordan balansen mellom omega-3 og omega-6 har endret seg i moderne kostholdNaturens slankemiddelHvorfor ultraprosessert mat hindrer metthetInflammasjon og anti-inflammatorisk næringHvilke oljer som tåler varme, og hva som skjer med fett under steking og prosesseringTran, fiskeolje, krillolje og andre marine oljer – hva skiller dem?Hvordan ulike fettsyrer påvirker metthet, GLP-1 og energireguleringHvorfor maten vi spiser henger sammen med havet, planktonet og hele næringskjedenHva Jan ville anbefalt både voksne og barn å spise for god helseDette er en episode som utfordrer mye av det vi tror vi vet om fett, og gir et nytt perspektiv på hvorfor kvaliteten og sammensetningen av fettsyrene vi spiser kan være avgjørende for helsen vår.For mer fra Jan raa:instagram.com/janraa_professoremeritusE-post: jan.raa.privat@gmail.comjanraa.noØnsker deg en nydelig uke!AnnetteFølg meg gjerne på:Instagram.com/dr.annettedraglandFacebook.com/drannettedraglandhttps://youtube.com/@drannetteDisclaimer: Innholdet i podcasten og på denne nettsiden er ikke ment å utgjøre eller være en erstatning for profesjonell medisinsk rådgivning, diagnose eller behandling. Søk alltid råd fra legen din eller annet kvalifisert helsepersonell hvis du har spørsmål angående en medisinsk tilstand. Hosted on Acast. See acast.com/privacy for more information.

In this episode, John W. Wood II, DHA, MBA, FACHE, Chief Executive Officer, PAM Rehabilitation Hospital of Sugar Land, discusses strengthening organizational culture, improving post-acute care outcomes, adopting AI responsibly, and the importance of continuous learning in healthcare leadership.

Episode Description: That stiffness when you wake up. The puffiness in your face. Feeling exhausted after eight hours of sleep. That is inflammation. And chronic inflammation is a low silent fire burning in your body every single day, quietly driving almost every disease you are afraid of. Most people have already spent good money trying to fix it. Most of them felt nothing. And the truth is not that supplements for inflammation are a scam. The truth is that most of what is on the shelf is underdosed, in the wrong form, and targeting the wrong pathway. Dr. G breaks down four supplements with real research behind them, the exact doses used in the trials, and the label tricks companies use to take your money without delivering results. Dr. G breaks down his anti-inflammatory protocol — in order: Take 1: "Ibuprofen does not lower your inflammation" Dr. G exposes why the most common go-to for pain and inflammation is only a temporary mask, not a fix. He reveals the molecule your body already makes to shut inflammation off and how to actually support it. Take 2: "One capsule of fish oil a day is doing close to nothing" The dose that moves inflammatory markers in real bloodwork is dramatically higher than what most people take. Dr. G gives the exact EPA and DHA number to hit and shows how to spot the label trick that makes you think you are getting more than you are. Take 3: "Boswellia hits a branch of inflammation that fish oil cannot reach" This is the one almost nobody is talking about. Dr. G breaks down why Boswellia serrata blocks a completely different inflammatory pathway and what has to appear on the label or the product is essentially useless. Take 4: "Cheap curcumin exits your body before it does anything" The most counterfeited anti-inflammatory supplement on the shelf gets a full breakdown. Dr. G explains what absorption actually requires, why black pepper is not enough, and what form to look for instead. Take 5: "Ginger is criminally underrated" It is dirt cheap, probably already in your spice drawer, and blocks both major inflammatory pathways. Dr. G makes the case for why ginger belongs in every anti-inflammatory protocol and what dose the research actually used. In this episode, you will learn: •  Why ibuprofen only presses the alarm button down temporarily while your body already has its own system for switching inflammation off, and how omega-3s at a real dose provide the raw materials for that system to work •  Why Boswellia serrata blocks a completely different branch of inflammation than ibuprofen or fish oil, why that matters if you have joint or autoimmune issues, and the one number that has to appear on the label or you have no idea what you are getting •  Why cheap curcumin is barely absorbed and exits your body before it does anything, what standardized and phytosome actually mean, and why ginger at one to three grams a day lowered objective inflammatory markers in clinical trials Plus why none of these four supplements will work if chronic stress is keeping your nervous system in low grade fight or flight every day. Product reviews assess both brand transparency and product quality. If a company doesn't respond to our outreach, it doesn't automatically mean their product is low quality but it does mean they're failing their customers on transparency and communication. We reach out multiple times. No response isn't an oversight, it's a choice. And consumers deserve better. Timestamps: 0:00 - Intro 1:00 - Why Most Inflammation Supplements Have Done Nothing for You (And Who's Responsible) 2:00 - What Ibuprofen Actually Does — And What It Completely Misses 2:45 - Supplement #1: The Molecule That Actually Switches Inflammation Off 4:30 - The Exact Dose That Moves Your Inflammatory Markers in Bloodwork 5:30 - The Fish Oil Label Scam That's Making You Pay for Filler Oil 7:00 - Supplement #2: The One That Hits the Inflammation Pathway Ibuprofen Can't Reach 8:30 - The Label Red Flag That Means You Have No Idea What You're Actually Taking 9:00 - Supplement #3: The Most Bootlegged Anti-Inflammatory Supplement on the Market 10:00 - The Absorption Problem That Makes Most Turmeric Products Useless 11:00 - Supplement #4: The Cheapest and Most Underrated One — Already in Your Spice Drawer 12:00 - Why All Four Supplements Will Barely Work if You Don't Fix This First 13:15 - Who Needs to Be Careful Before Starting Any of These 13:45 - The One Blood Test to Ask Your Doctor for Right Now Get your free guide from Dr. G:  https://page-builder-christiangon110.replit.app/opt-in/ Learn more about your ad choices. Visit megaphone.fm/adchoices

Are You Actually Inflamed? The Foods That Help Your Skin, Brain & MoodAngelo Keely is the co-founder and CEO of Kion, a health and performance company focused on helping people feel and perform their best through evidence-based nutrition. He joins me to break down one of the most talked-about—and often misunderstood—topics in wellness: inflammation, and how what we eat can impact everything from our skin and brain to mood and long-term health.We talk about what chronic low-grade inflammation actually is, how to know when inflammation is normal versus potentially problematic, and the lifestyle factors that can make a meaningful difference. Angelo explains why certain types of fats are so important, the foods we should be eating regularly to get enough of them, and how much fatty fish like sardines, anchovies and mackerel you'd realistically need to eat to reach optimal levels.We also get into how to test your omega-3 levels, the connection between omega-3s and skin health, mood and cognitive function, and what women should know during pregnancy. Plus, Angelo breaks down vegan sources, why EPA and DHA percentages matter, what to look for in a supplement, and why sourcing, purity and heavy-metal testing are so important.Visit getkion.com/well for 20% off and connect with Angelo in instagram @kionThis episode may contain paid endorsements and advertisements for products and services. Individuals on the show may have a direct, or indirect financial interest in products, or services referred to in this episode.Produced by Dear Media. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

The PBM Reform Podcast, sponsored by APCI, welcomes John Vinson, PharmD, Chief Executive Officer of the Arkansas Pharmacists Association, for a timely conversation with host Greg Reybold about the management of the TRICARE pharmacy benefit.   Express Scripts administers pharmacy benefits for TRICARE, the Department of Defense healthcare program serving more than 9 million active-duty service members, military retirees, and family members. In fiscal year 2023 alone, TRICARE spent more than $8 billion on prescription medications.   Greg and John examine concerns surrounding Express Scripts' administration of the program, including shrinking pharmacy networks, reduced patient choice, questionable contractor reporting, specialty-drug delivery oversight, and the consequences for independent and rural pharmacies.   A 2025 Government Accountability Office investigation found that:   TRICARE's minimum network requirement fell from 50,000 to 35,000 pharmacies. The network had approximately 13,165 fewer pharmacies in late 2024 than in late 2022. An estimated 380,000 beneficiaries may have been forced to find another pharmacy. The Defense Health Agency relied heavily on contractor-submitted reports that contained inaccuracies. DHA had not consistently audited the data used to evaluate beneficiary access. GAO's two corrective recommendations remain open as of August 2026, although DHA has begun adding reporting and auditing requirements.   The episode also addresses higher 2026 prescription copayments. For most non-active-duty beneficiaries, home-delivery copays are now $14 for generic formulary drugs, $44 for brand-name drugs, and $85 for non-formulary medications. At retail network pharmacies, the corresponding 30-day copays are $16, $48, and $85.   Greg and John discuss whether PBM-driven network reductions represent true savings—or simply transfer costs, inconvenience, and access barriers to military families and the community pharmacies serving them.   Key discussion points Express Scripts' role in administering the TRICARE pharmacy benefit Pharmacy network contraction and beneficiary disruption Access challenges facing rural communities and military families Inaccurate contractor data and insufficient federal oversight Specialty-pharmacy delivery and monitoring concerns Rising 2026 copayments and pressure toward mail order Arkansas' leadership in challenging PBM vertical integration The need for transparency, accountability, adequate reimbursement, and patient choice   Important clarification: TRICARE is administered by the Department of Defense and is distinct from healthcare and pharmacy services operated by the Department of Veterans Affairs.   Sponsored by APCI — American Pharmacy Cooperative, Inc.   Sources: U.S. Government Accountability Office, TRICARE's 2026 pharmacy-benefit update, official 2026–2027 pharmacy costs.

IN THIS EPISODE   You've probably heard that omega-3s are good for you. But few people realize just how crucial they are for brain health, inflammation, and so much more… and just how many of us aren't getting enough.   In this episode of the ReThink Health Podcast, I sit down with Dr. Philip Calder, Professor of Nutritional Immunology at the University of Southampton and one of the world's leading researchers on omega-3 fatty acids and inflammation.   According to Dr. Calder, an estimated 75% of people worldwide aren't getting enough EPA and DHA, the omega-3s most strongly linked to human health. And over time, low omega-3 status may contribute to greater risk of cardiovascular disease, metabolic disease, cognitive decline, and other conditions associated with aging. Come explore why DHA is especially important for the brain, how omega-3s may support muscle as we age, the nuanced truth about omega-6 seed oils, and simple ways to improve your omega-3 status through food and supplements.   You'll learn: How omega-3s change your cell membranes and influence how your cells function How EPA, DHA, and DPA literally help turn off inflammation Why DHA plays a unique role in the brain, vision, and cognitive function The difference between EPA and DHA (and why you need both) How omega-3s may support muscle protein synthesis and healthy aging The surprising connection between omega-3s, fertility, pregnancy, and infant development Why the balance between omega-6 and omega-3 fatty acids matters The best food sources of EPA and DHA, and how much Dr. Calder recommends getting each day How the Omega-3 Index can help reveal your long-term omega-3 status and future health risks   If you're not regularly eating fatty fish, there's a good chance you're missing out on these critical fats. This episode explains exactly why omega-3s matter and the practical steps you can take to get more of them.   VALUABLE RESOURCES Paleovalley Omega-3 Complex >>> Support brain, heart, cellular, and whole-body health with 1,050 mg of clean, bioavailable omega-3s per serving. Save up to 20% on Paleovalley Omega-3 Complex.   BIO Dr. Philip Calder is a Professor of Nutritional Immunology at the University of Southampton whose research explores how nutrition influences immune function, inflammation, and human health.   With a background in metabolic biochemistry, Dr. Calder began studying how immune cells use fatty acids nearly four decades ago. His discovery that different fatty acids could actually change the way immune cells function helped lead him into the emerging field of nutritional immunology. Today, his research focuses extensively on the effects of dietary fats (particularly omega-3 fatty acids) on immunity, inflammation, and health.   THANKS FOR LISTENING! Thanks so much for joining us this week! Have feedback or a question? Email us at support@paleovalley.com—we'd love to hear from you. If you enjoyed this episode, please share it with someone who might benefit from the information. Following the ReThink Health Podcast on YouTube, Spotify, or iTunes helps us reach more people who need to hear this and keeps you updated on new episodes. Likes, subscribes, ratings and reviews are incredibly helpful and deeply appreciated—we read every single one! Let's spread this knowledge and help others together. See you next time! Click below to follow on YouTube, Spotify or iTunes:  

Dr. Klaper recommends tracking omega-3 levels and possibly supplementing DHA to support brain and heart function. #Omega3s #BrainHealth #VeganSupplements #HealthTalks

The Future of Inflammation Resolution In this episode of Live Foreverish, Dr. Mike and Dr. Crystal welcome Harvard researcher Dr. Charles Serhan to discuss resolution medicine, a groundbreaking field focused on activating the body's natural inflammation-resolving mechanisms. Dr. Serhan explains how specialized pro-resolving mediators (SPMs), derived from omega-3 fatty acids like EPA and DHA, actively resolve inflammation rather than simply suppressing it. This show offers promising new strategies for treating chronic inflammatory diseases. #LELEARN #EDULFsocial Guest Bio: Prof. Charles Nicholas Serhan, PhD, DSc is the Simon Gelman Professor of Anaesthesia (Biochemistry and Molecular Pharmacology) at Harvard Medical School and Professor of Oral Medicine, Infection and Immunity at Harvard School of Dental Medicine. He is Director of the Center for Experimental Therapeutics and Reperfusion Injury at Brigham and Women's Hospital. He has received several awards including an NIH MERIT award (2000) and has delivered over 50 keynote and plenary lectures. Among these, 2008 William Harvey Outstanding Scientist Medal and AAAS Fellow in 2011. In 2010, he received the Society for Leukocyte Biology Bonazinga Award for outstanding research on leukocytes, The American College of Rheumatology Hench (Nobel Laureate) Award Lecture in 2011 and is a Mérieux 2013 Laureate. In 2016, he received the IUBMB Lecture Medal and the Ross Prize in Molecular Medicine. In 2017, he received the International Eicosanoid Research Foundation's Lifetime Achievement Award and the American Society of Investigative Pathology (ASIP) 2018 Rous Whipple Award.

The Reecet: Live Q&A, recorded in Los Angeles with 45 women after three and a half days of training, I sat down with Dr. Abbie Smith-Ryan, exercise physiologist and professor at UNC Chapel Hill, to cut through the noise on supplements, menopause, AI, and what actually holds up in real life.What we explore:* Why AI accelerates health research but still needs human oversight to be useful.* How to prioritize supplements after menopause: omega-3, vitamin D, and magnesium.* What the omega-3 index test tells you and how to dose EPA and DHA.* How to time protein, creatine, and essential amino acids for better results.* Why worrying less, gratitude, and choosing relationships change your health.* Where menopause hormone therapy still has gaps, from the SSRI trial to unanswered questions.* How sunlight and red light tools fit into a real recovery routine.* Why reclaiming your time and attention matters more than any new trend.* How intuition and imposter syndrome shape the way women show up.* Why simple non-negotiables around training, sleep, and boundaries beat trends.Chapters:* 00:00 The Reecet One Health Q&A* 01:35 Should You Worry About AI and Your Health?* 05:56 The First Supplement to Take After Menopause* 08:29 How to Worry Less and Consistency Beats Doing It Perfectly* 13:46 Why Relationships Matter More Than Success* 20:00 How to Translate Health Science Into Real Decisions* 22:51 How to Time and Stack Your Supplements* 25:52 Why Sunlight Deserves a Spot in Your Routine* 34:24 The Biggest Unanswered Question in Women's Health* 37:30 How to Spot Trends Worth Following* 47:51 How to Build Community and Keep It Alive* 50:13 The Simple Health Non-Negotiables That Matter* 01:05:00 Why Sweating Together Bonds Women for LifeAbout Dr. Abbie Smith-Ryan:Dr. Abbie Smith-Ryan is a professor of exercise physiology and nutrition at the University of North Carolina at Chapel Hill, where she directs the Applied Physiology Laboratory. Her research focuses on exercise and nutrition interventions for body composition, metabolism, and women's health across the lifespan, including perimenopause and menopause.Connect with Dr. Abbie Smith-Ryan:Website:http://asmithryan.comInstagram: https://www.instagram.com/asmithryan/–The Gabby Reece ShowThis is where I have real conversations with the people I find most worth listening to: scientists, athletes, coaches, parents, and thinkers who are doing the hard work of building a life that holds up over time. No hacks. No quick fixes. Just honest, practical conversations about performance, longevity, relationships, and what it actually takes to show up well at every age.If you are here, you probably already know that health is not a destination. It is how you live. I am glad you are along for it.Connect with Gabby Reece:Instagram: https://www.instagram.com/gabbyreece/TikTok: https://www.tiktok.com/@gabbyreeceofficialWebsite: https://gabbyreece.com This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit thegabbyreeceshow.substack.com

In this episode, Kelly Haynie, DHA, MPA, FACHE, Chief Executive Officer, Ochsner Medical Center - West Bank Campus, discusses leading through growth, building a strong leadership culture, and preparing healthcare organizations for AI-driven transformation. He shares how AI can improve access, experience, quality and safety while reducing administrative burden and keeping care human.

The conversation explores the idea that human brains may have been shrinking due to a missing piece in the modern diet - DHA (decossa hexanoic acid). It delves into the importance of DHA as a structural brain fat, the historical context of human brain size, the significance of DHA in seafood, and the impact of DHA on brain health and development.TakeawaysDHA is a crucial structural brain fatSeafood is an important source of DHAChapters00:00 The Missing Piece in the Modern Diet02:12 The Importance of DHA in Brain Structure03:36 Historical Context of Human Brain Size06:47 The Significance of DHA in Seafood09:30 Impact of DHA on Brain Health and Development

The Future of Inflammation Resolution In this episode of Live Foreverish, Dr. Mike and Dr. Crystal welcome Harvard researcher Dr. Charles Serhan to discuss resolution medicine, a groundbreaking field focused on activating the body's natural inflammation-resolving mechanisms. Dr. Serhan explains how specialized pro-resolving mediators (SPMs), derived from omega-3 fatty acids like EPA and DHA, actively resolve inflammation rather than simply suppressing it. This show offers promising new strategies for treating chronic inflammatory diseases. #LELEARN #EDULFsocial Guest Bio: Prof. Charles Nicholas Serhan, PhD, DSc is the Simon Gelman Professor of Anaesthesia (Biochemistry and Molecular Pharmacology) at Harvard Medical School and Professor of Oral Medicine, Infection and Immunity at Harvard School of Dental Medicine. He is Director of the Center for Experimental Therapeutics and Reperfusion Injury at Brigham and Women's Hospital. He has received several awards including an NIH MERIT award (2000) and has delivered over 50 keynote and plenary lectures. Among these, 2008 William Harvey Outstanding Scientist Medal and AAAS Fellow in 2011. In 2010, he received the Society for Leukocyte Biology Bonazinga Award for outstanding research on leukocytes, The American College of Rheumatology Hench (Nobel Laureate) Award Lecture in 2011 and is a Mérieux 2013 Laureate. In 2016, he received the IUBMB Lecture Medal and the Ross Prize in Molecular Medicine. In 2017, he received the International Eicosanoid Research Foundation's Lifetime Achievement Award and the American Society of Investigative Pathology (ASIP) 2018 Rous Whipple Award.

Episode Description: Wired and exhausted at the same time. Weight around your midsection that will not move no matter what you do. Mind racing the moment your head hits the pillow. That is not too much cortisol. That is a cortisol curve that has lost its shape. And there is a very real difference between those two things. Before Dr. G gets into the four supplements that have actual human research behind them, he is going to expose the cortisol detox teas and adrenal fatigue narrative for what they are. You cannot detox a steroid hormone. And the concept of adrenal fatigue was examined across 58 studies and has no scientific basis. What you actually have is a dysregulated HPA axis, and that is something you can actually fix. In this episode, you will learn:  •  Why ashwagandha is the most proven cortisol lowering supplement on earth by a wide margin, the exact label trick companies use to sell you an underdosed product, and who should never take it regardless of stress levels  •  The difference between the person who spikes easily under pressure and the person who crashes after sustained stress, why these require completely different supplements, and what phosphatidylserine and rhodiola each do that the other cannot  •  Why 45% of fish oil on shelves is already rancid, how to read the label to find out if your EPA and DHA numbers are actually therapeutic, and how omega-3s physically blunt both resting cortisol and cortisol spikes under stress Plus the one warning sign that means your cortisol issue is not everyday stress and you need to see a doctor immediately.Product reviews assess both brand transparency and product quality. If a company doesn't respond to our outreach, it doesn't automatically mean their product is low quality but it does mean they're failing their customers on transparency and communication. We reach out multiple times. No response isn't an oversight, it's a choice. And consumers deserve better. Timestamps: 0:00 - Intro 0:45 - Cortisol Detox Teas Are a Scam — Here's Why in 30 Seconds 1:30 - What the Cortisol Curve Actually Is (And What Chronic Stress Does to It) 2:45 - The Belly Fat, Sleep and Energy Connection Nobody Explains Correctly 3:45 - Supplement #1: The Most Proven Cortisol-Lowering Herb on Earth 5:30 - The Label Tricks Companies Use to Quietly Drain Your Wallet 6:15 - Who Should Never Touch This Supplement (Especially Thyroid Conditions) 6:45 - Supplement #2: The One for People Who Spike Hard Under Pressure 8:15 - Why the Lower Dose Does Absolutely Nothing (The Research Is Precise) 8:45 - Supplement #3: The Adaptogen for People Who Can't Get Out of Bed in the Morning 10:30 - The Most Manipulated Supplement in This Category and How to Spot a Fake 11:15 - Supplement #4: The Foundation Sitting Beneath All Three 12:30 - The Fish Oil Label Scam That's Making People Pay for Rancid Oil 13:30 - The One Thing That Beats All Four Supplements Combined 14:30 - When Your Cortisol Problem Is Actually Something More Serious Learn more about your ad choices. Visit megaphone.fm/adchoices

V tomto díle si bereme na paškál omega-3 mastné kyseliny se dvěma odborníky: Pavlem Samkem (výroba a legislativa doplňků) a Petrem Havlíčkem (výživový poradce). Probíráme, jestli omega-3 vůbec potřebujeme suplementovat, jaká dávka dává smysl pro běžného člověka a jaká pro sportovce, a kdy se z „zdravé" dávky stává riziková (fibrilace síní, krvácivost). Rozebíráme mýty kolem oxidace a žluknutí rybího tuku, vysvětlujeme, co znamená TOTOX, a ukazujeme reálný experiment se skladováním kapslí v rozpáleném autě. Řešíme rozdíl mezi triglyceridy a etylestery, proč vyšší % EPA/DHA neznamená automaticky lepší produkt, jestli je důvod bát se těžkých kovů, a jak si omega-3 vybrat, aby to dávalo smysl i pro peněženku. Padne i téma omega-3 v těhotenství a jestli suplement může nahradit ryby na talíři. Ideální díl pro každého, kdo si omega-3 kupuje, ale netuší, na co se u etikety vlastně dívat.

What happens when two of the top holistic veterinarians in the country get together for a chat??? Pure magic! Listen in as Dr. Judy Morgan and Dr. Karen Becker discuss the challenges of pet food regulation, particularly the high costs and limited consumer representation at AAFCO meetings. They highlight the difficulties small manufacturers face, including the need for individual recipe registration in each state. They advocate for homemade pet food as a cost-effective and high-quality alternative. They also discuss the importance of proper nutrition, including the need for DHA and EPA, and the issues with all-life-stages feeding. Additionally, they share their experiences with homesteading and raising their own food, emphasizing the benefits of fresh, chemical-free ingredients for both pets and humans. www.drkarenbecker.com https://www.facebook.com/doctor.karen.becker https://www.instagram.com/drkarenbecker/ PRODUCT SPOTLIGHT #1 Another day. You've got your routine, and they do too. At first, it's endless energy and curiosity. Every moment brings something new. Hey are you hungry? Then, before you know it, they become part of your rhythm. They know when to follow and when to just sit beside you. Even when things start to get a little slower, a little quieter, they're still there, same place every morning. Different days, different speeds, same place in your life. AllProvide Holistic Pet Food ensures that your pet's life is filled with many tomorrows by providing them with a nutritious and proactive diet that puts their happiness and wellness first. Because for them, it's never just another day; it's another chance to be part of their best friend's life. AllProvide. This is food therapy. Use code DRJUDY20 for 20% off your next order at AllProvide.com. This code is good for one time per customer. PRODUCT SPOTLIGHT #2I hear from many pet parents that there's an immediate stress reaction when they notice a problem with their pet. Is it a symptom of a health problem, will it disappear on its own? Do they need to call their veterinarian? Panic sets in because you want to do everything to protect the health of your pet. Now there's a way to advocate for your pet's health that can eliminate the stressful guesswork. Dr. Ruth Roberts offers a holistic pet health coach program where you take control of your pet's health. This is not your typical quickie course to get limited bits of information. This comprehensive program teaches the scientific foundation of your pet's system to understand health issues and how nutrition, natural supplements, and therapies can support intermediate care. This is truly a complete pet healthcare program, so avoid the stress. You can go to the Holistic Pet Health Coach website for more information, and you can get a special one-time discount of $250 if you use the code DRJUDY when you apply. To learn more, visit druthroberts.com/pages/coach or scan the QR code shown here. This discount is valid until December 31 2026. This episode is sponsored by Dr. Ruth Roberts Holistic Pet Health Coach Program, where you learn to take control of your pet's healthcare. PRODUCT SPOTLIGHT #3Here's something most dog owners don't know: dogs cannot produce EPA and DHA on their own. These essential omega-3 fatty acids must come from their diet, and without enough of them, the effects show up in ways we often mistake for just getting older: a dull coat, stiff joints, brain fog, low energy. These are not inevitable. They're often signs of a nutritional gap that can be filled. Feel Good Omega was created by Dr. Peter Dobias to do exactly that. Made from pure wild squid oil, sustainably harvested, made in Norway, and Friend of the Sea certified, it delivers the highest quality EPA and DHA in their most bioavailable form, microfiltered, lab tested, protected against rancidity by nitrogen, and bottled in glass. It also comes with a lifetime money back guarantee. Head to peterdabias.com and use code DRJUDY10 for 10% off. Your dog deserves to feel good.

Episode Summary The Responsible Seafood Summit returns to Bangkok, Thailand, bringing together seafood professionals from across the global value chain for four days of learning, collaboration, and meaningful industry connections. Hosted by the Global Seafood Alliance, the Summit creates an environment where producers, retailers, suppliers, researchers, NGOs, policymakers, and seafood leaders can exchange ideas, explore emerging challenges, and work toward practical solutions that strengthen the future of responsible seafood. This year's program highlights major industry priorities including global seafood markets, aquaculture production, fisheries, animal health and welfare, feed innovation, labor practices, and seafood supply chains. With a new program structure that combines broad industry discussions with focused deep-dive sessions, attendees will have opportunities to gain valuable insights, build new partnerships, and help shape the conversations driving seafood sustainability and innovation worldwide. Episode Sponsor Thank you to Veramaris for sponsoring this episode of the Aquademia podcast Their vision is bold: reshaping how the world is nourished with Omega-3. By pioneering new ways to deliver essential nutrition, Veramaris supports the aquaculture industry in closing the Omega-3 supply gap. Through resilient innovation, they produce high quality EPA and DHA directly from natural marine algae, providing farmers with a secure, reliable supply to raise healthier fish. Earning trust in every drop of algal oil, Veramaris makes sustainable growth possible today, and tomorrow. Learn more at Veramaris.com and give them a follow on LinkedIN. Featured Guests Steve Hart Senior Vice President of Market Development Global Seafood Alliance Key Topics Covered Why Bangkok was selected to host the 2026 Responsible Seafood Summit The importance of returning the Summit to Asia The 2026 theme: Connect, Collaborate, Commit New program structure featuring plenary sessions and focused deep-dive discussions Global seafood market trends and changing consumer preferences Aquaculture production, feed innovation, and animal health Tuna sustainability, labor practices, and vessel connectivity Networking opportunities designed to encourage meaningful industry relationships Industry field trips showcasing Thai aquaculture, fisheries, feed production, and culinary experiences Executive keynote conversations with leaders from Binhuan, Umios, and Thai Union Key Takeaways The Responsible Seafood Summit emphasizes collaboration that leads to real industry action. Returning to Thailand places the event at the center of one of the world's most important seafood regions. New programming combines high-level industry perspectives with practical, solution-focused discussions. Networking is intentionally built into every aspect of the event through meals, receptions, tours, and the attendee app. Field trips provide firsthand experiences across aquaculture, fisheries, seafood production, and Thai culture. Industry leaders from across the seafood supply chain will share insights on navigating today's rapidly changing marketplace. The Summit offers valuable opportunities for professionals at every stage of their careers to build lasting relationships. Links and Resources Mentioned Responsible Seafood Summit (REGISTER) Seafood Nutrition Partnership - Summer Seafood Challenge The views expressed by external guests on Aquademia are their own and do not reflect the opinions of Aquademia or the Global Seafood Alliance. Listeners are advised to independently verify information and consult experts for any specific advice or decisions.

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Why Your Stroke May Not Be Causing Your Brain Fatigue For a long time after my brain surgery, I assumed my body worked like this: the stroke happened in my head, so whatever went wrong afterward would also happen in my head. Fatigue, brain fog, slow thinking all of it filed under “neurological,” all of it explained by the injury I already knew about. That assumption turned out to be wrong, and the way I found out was almost accidental. About eighteen months after my brain surgery, I had thyroid surgery to remove a nodule so large it had pushed my windpipe and esophagus six centimeters out of place. I had no idea it was there. No lump I could see, no difficulty swallowing or breathing that I’d noticed. It was found only because I had a chest X-ray to rule out an infection, and a doctor spotted something that had nothing to do with why I’d walked in. What followed was a slow, confusing recovery from that second surgery, and a wave of fatigue I automatically blamed on my brain, because that was the injury I already understood. It took time to realize the fatigue might be coming from somewhere else entirely: my thyroid. Hormones and Stroke Recovery: The Connection Nobody Talks About I brought this experience to Dr. Robert Hedaya, a Clinical Professor of Psychiatry at Georgetown University Medical Center and a pioneer of functional medicine psychiatry, to understand what actually happened, and to ask a bigger question: how many other stroke survivors are dealing with fatigue, brain fog, or mood changes that they’ve written off as “just the stroke,” when the real driver is a hormonal system that’s quietly stopped working properly? Hormones and stroke recovery turn out to be far more entangled than most of us are told. As Dr. Hedaya put it plainly: the brain is a hormonal organ. Thyroid hormone, cortisol, testosterone, estrogen every one of them acts directly on brain tissue, and every one of them can be knocked off balance by the stress of a major medical event. Why “Normal” Thyroid Bloodwork Can Still Mean Something’s Wrong One of the most important things Dr. Hedaya explained is that a “normal” TSH result doesn’t rule out a thyroid problem, especially after a stroke. TSH is a signal sent from the pituitary gland, and if a stroke has affected the brain’s signaling pathways, the pituitary itself may not respond the way it should. A survivor can have genuinely low thyroid hormone while their TSH sits comfortably inside the standard reference range, because the system responsible for raising that number in response to a deficiency isn’t functioning correctly. He also raised a striking data point: population studies suggest the average TSH in a healthy population is closer to 1.4, yet most labs still use an upper reference limit of 4.5, a range wide enough, statistically, to miss a real problem. His advice for survivors going into a GP appointment: ask specifically for TSH, free T4, free T3, and reverse T3, not just the standard single-marker test, and come prepared with symptoms written down if a doctor pushes back. A Nodule That Grew in Silence The brain is a hormonal organ. It’s an immune organ. It’s a neurological organ… there’s not one hormonal axis when it’s abnormal that cannot cause neurological or psychiatric problems. -Dr. Robert Hedaya My own nodule is a case study in exactly this kind of silent progression. Dr. Hedaya explained that because it grew inward rather than outward, it never created the visible lump most people associate with a thyroid problem, and because it didn’t press on my vocal cords or laryngeal nerve, I never developed the hoarseness that might have flagged it sooner. My body adapted gradually, and the fatigue that eventually surfaced was easy to misattribute to the injury I already knew I had. Cortisol, Stress, and the Difference Between Pain and Suffering Beyond the thyroid, Dr. Hedaya walked through the role of cortisol, the body’s primary stress hormone, and why survivors often struggle to answer a deceptively simple question: “Are you stressed?” His distinction between pain and suffering is worth sitting with: pain is often unavoidable, but suffering is shaped by the story we tell ourselves about a situation, and a stroke can compromise the very brain systems that regulate that stress response in the first place. Testosterone, Estrogen, and the Brain’s Need for Hormones to Rewire The conversation closed on sex hormones, testosterone and estrogen, relevant to both men and women, and their role in neuroplasticity. Dr. Hedaya drew a direct comparison to adolescence: the teenage brain rewires itself while hormone levels are surging, and the same principle applies after a stroke. A brain trying to rebuild pathways needs adequate hormonal support to do that work. Without it, recovery can stall in ways that have nothing to do with effort or physiotherapy. What You Can Do About It If any of this sounds familiar fatigue that doesn’t track cleanly with other recovery milestones, or symptoms a doctor has waved off as “just stress,” Dr. Hedaya’s PNIE (psycho-neuro-immuno-endocrinology) questionnaire is a useful starting point. PNIE Questionnaire download: https://drive.google.com/file/d/1S7kC5uMFgBfS-gWcUOIHp0kOjGnrzZK5/view?usp=sharing If thyroid function specifically is what you’re navigating, the earlier conversation with Dr. Elena Zinkov, “Stroke Fatigue and Thyroid,” goes deeper into that piece (https://recoveryafterstroke.com/stroke-fatigue-and-thyroid/). And for more from Dr. Hedaya, the first conversation on photobiomodulation and stroke recovery is a good companion listen (https://recoveryafterstroke.com/photobiomodulation-stroke-recovery/). Getting your body back after a stroke is rarely just about the brain. My book, The Unexpected Way That A Stroke Became The Best Thing That Happened, goes further into the mindset shifts that came out of my own recovery (recoveryafterstroke.com/book). And if this podcast has helped you, you can support its continuation at patreon.com/recoveryafterstroke. This blog is for informational purposes only and does not constitute medical advice. Please consult your doctor before making any changes to your health or recovery plan. Hormones, Fatigue, and the Brain: Dr. Robert Hedaya Returns (Interview) A baseball-sized thyroid nodule hid in plain sight after Bill’s stroke. Dr. Hedaya explains the hormone testing every survivor should ask for. Support The Recovery After Stroke Podcast Bill’s Book: The Unexpected Way That a Stroke Became Thethe Best Thing That Happened Highlights: 01:45 Hormones and Stroke Recovery 02:11 Understanding Thyroid Function and Its Impact 17:07 Navigating Thyroid Health with Healthcare Providers 27:09 The Role of Stress and Cortisol 39:09 Nutrition’s Impact on Brain Recovery Transcript: Hormones and Stroke Recovery Bill Gasiamis (00:00) And they noticed a massive lump in my throat and my esophagus and my windpipe were pushed six centimeters. And they said to me, well, can you swallow? Can you breathe? Can you do it? And I was like, yeah, I’m all fine. There’s nothing wrong with my throat. that was the first sign that there was something wrong with my thyroid Bill Gasiamis (00:19) Welcome back to Recovery After Stroke. I’m Bill Garciamas, and today I’m joined again by Dr. Robert Hedeya, clinical professor of psychiatry at Georgetown University Medical Center and a pioneer of functional medicine psychiatry, whose highland approach to brain health first brought him onto the show for our conversation on episode 404, where we discussed, amongst other things, photobiomodulation, a type of transcript. cranial laser therapy helping some stroke survivors recover lost function. He’s back today for a conversation I wanted to have for a while, the hormonal side of stroke recovery. We’re going to talk about thyroid function, cortisol, and stress physiology, and sex hormones like testosterone and estrogen, and why every one of these systems can directly affect how well and how fast your brain recovers. I’ll also share my own story of a thyroid nodule that grew undetected, which was discovered after my brain surgery completely by accident. if this conversation resonates with you, my book, The Unexpected Way That a Stroke Became Thethe Best Thing That Happened goes deeper into the mindset shifts that shaped my own recovery. You can find it at recoveryafterstroke.com/book. And if you’d like to help keep this podcast going, you can support it financially at patreon.com/recoveryafterstroke. Bill Gasiamis (01:46) Robert Hedaya, welcome back to the podcast. Dr Hedaya (01:49) Thank you for having me, Bill. Understanding Thyroid Function and Its Impact Bill Gasiamis (01:51) thank you for being here. The last conversation we had was very well received. And it’s always difficult in a one hour interview to ask all the questions that we could possibly ask about the brain and stroke recovery and all the things that people go through. And… I’ve got a lot of other questions that are related to the brain and the link between other parts of the body and the brain, because we have this sense. Well, I did at least when I was first diagnosed that whatever happens in my head is kind of isolated, that it just impacts my head. But there seemed to be some other impacts and cascading effects. that were occurring, uh, that I didn’t know were linked to the brain injury, Dr Hedaya (02:45) Yeah. Bill Gasiamis (02:46) maybe indirectly, but they were perhaps. But one thing specifically that happened to me about, uh, 18 months after my brain surgery was I had thyroid surgery to remove a nodule on my thyroid. And when I was going through the recovery after that, surgery, I noticed that I had fatigue and I thought it was neurological fatigue related to my brain surgery. But it took a long time to develop an understanding that perhaps that batch of fatigue was related to my thyroid. And then that got me thinking all sorts of things. know, if the thyroid also causes the same neurological fatigue that brain injury causes, what people might be missing this in their healing from a brain injury, they might have a compromised thyroid and not know about it. So the first question is, what is a thyroid? What does it do? And why does it cause neurological fatigue? Dr Hedaya (03:54) Okay. So thyroid gland sits in the neck, right? There’s two lobes, there’s one on the right, one on the left, a little kind of island in the middle called the isthmus, and and it controls many functions, metabolism overall, energy overall, just broadly speaking. now it affects the immune system. It’s affects the nervous system. It affects the gastrointestinal system, it affects the muscles, it affects the heart, right? It affects the skin, it affects the nails, it affects the hair. You know, and I could go on and on and on. Okay? Bill Gasiamis (04:34) Wow. Dr Hedaya (04:35) Now the interesting thing about this is that this be a little technical, but the thyroid puts out a hormone called T4 or thyroxine, and this is a little molecule with four iodines in it on it, and that Gives you about 20% of the activity of your thyroid hormones in your body. But then that T4 goes all over the body to different tissues, and each tissue can has its own system to change that T4 into T3 by removing an iodine. T3 has 80% of the thyroid activity. So that means each tissue in the body can control how much thyroid it. It’s using and needs, right? And and has available to it. Okay. So that means the brain, the heart, the liver, the lungs, every tissue has its own enzyme that allows it to kind of modulate how much thyroid, right? Now, so why does that cause neurological fatigue? Well, thyroid in the brain affects neurotransmitters like adrenaline in the brain, which is called nor norepinephrine, noradrenaline. in order for that to work. The T3 has to be in the right amount for the receptors for the noradrenaline to be structurally correct so they can transmit the signal. It’s necessary for production of energy in all the brain cells. It helps the immune system in the brain. It carries molecules from here to there in the brain. it affects serotonin transmission in the brain, so mood regulation, anxiety, obsessiveness, depression. You know, those are just some of the functions of the brain, but it affects every cell in the bane in the brain. So you’re gonna, if your thyroid is off, most likely you’re gonna have some kind of brain problems, particularly, you know, when your thyroid is off, the tissues in your body that are most compromised or most stressed, that’s probably where it’s gonna show up, right? And in the case of stroke, that’s where it’ll show up. Bill Gasiamis (06:44) So it’s possible then, is it possible to overlook it? Is it very obvious that your thyroid is out of, well, is dysregulated or is not working properly? Dr Hedaya (06:56) Well, in general it’s easy to detect. And if you want, I’ll tell you how. So Bill Gasiamis (07:04) Yeah. Tell me how. Dr Hedaya (07:07) so there’s some blood tests that are simple and then s some symptoms. so for most people this holds. When your thyroid is low, you know, you’re gonna be cold easily, you’re gonna have dry skin, brittle nails, hair will fall out. Muscles will be weak, thinking will be slow, movement will be slow, getting up from a chair will be more difficult, going upstairs will be more difficult, your heart rate will slow down, you’ll be constipated. Those are the most common symptoms. If your thyroid is overactive, then you could be have palpitations, oily skin, acne, oily hair. Diarrhea, you know, kind of the opposite. The thing that’s a little confusing with the thyroid is sometimes overactive thyroid can show up and look like it’s underactive symptomatically, or vice versa. So you really need the labs. And the labs are TSH, which is thyroid stimulating hormone, and that’s tells you what the brain is doing. And then free T4. That’s the amount of T4 that’s kind of floating around free, not bound to protein, so it can actually do its job. The way I think of it is like, you know, a lot of the thyroid home is sitting on a bus. It’s not free, it’s bound to protein. Can’t do its job. But the stuff the thyroid this that’s out of the bus or not on a protein, that can do its job. That’s the free T four. And then the free T three, right, which carries eighty percent of thyroid activity. And then the last one is a reverse T3 because sometimes if your tissues in your body are making too much thyroid or getting too much thyroid, they’ll actually, instead of taking the iodine off the T4 molecule on the right side, they’ll take it off on the left side, or vice versa. So they make a fake T3 that doesn’t work. And this way they short circuited okay, you got all this T3. Well, let’s make it into a fake, fake T3 so it can’t do anything. So reverse T3 is also very important. And then you want to measure body temperature. Usually it’ll be low. And then, you know, a physical exam. Those are the ways to do it. If you wanted to go even deeper, you could do some genetic testing. There are genes that will tell you whether you’re converting the T4 to T3 in the brain. Adequately, or maybe you’re more likely to be slow in that regard. So you can have normal numbers in your blood, but your brain might be hypothyroid, right? And there are actually a lot Bill Gasiamis (10:05) Uh-huh. Dr Hedaya (10:05) of studies showing that hypermetabolic, like high doses of free T3, actually reverse treatment-resistant depression because it’s it’s thought that there’s a local in-brain. hypo-low thyroidism. You can have low thyroidism in your heart, in your muscles, but not in the other tissues, you know, because I told you every tissue can control how much it’s making. So if you have a genetic vulnerability, then you you might more be in general be more likely vulnerable to depression or to ADD or to anxiety, things like that. Bill Gasiamis (10:42) Wow. Are you blowing me away? I didn’t expect to hear any of the things that you just said. X. Um, some of the things that you described, the, uh, some of the symptoms that you described, had those intermittently in and out all the time, other than a thyroid nodule, which is what I had, which was obvious on a scan. Dr Hedaya (11:05) Yeah. Bill Gasiamis (11:06) What other things caused the thyroid to not function? correctly. So is there lifestyle factors that interfere with the thyroid gland and therefore, you know, then have the cascading effect and take off, take all those other things or some of those other things offline. Dr Hedaya (11:28) So there a number of causes, right? So first of all, let’s take someone who has had a stroke or chronic illness, right? So you’re under stress and that affects your stress hormones, your adrenal glands, cortisol, etc. Well, if your adrenals kind of poop out, then maybe your body says, Well, I can’t handle all this thyroid, even though the amount is normal, it’s like too much. I can’t handle it, so it’ll make less thyroids. Now you develop a hypothyroidism. You could develop it just because all the chemicals in the environment, the ha the hormone interrupting chemicals, there are hundreds of those. you could develop it ’cause of nutritional deficiencies like tyrosine is necessary to make thyroid hormone, copper, you know, things like that. I can’t tell you offhand which which nutritional factors, but people can look that up, what nutritional factors are important. To make thyroid hormone. and then infections like, for example, Lyme disease causes Hashimoto’s thyroiditis, which is an autoimmune where your immune system’s actually attacking your thyroid. COVID vaccination, like the Pfizer and the Moderna vaccine, if you are genetically vulnerable, can also cause your immune system to attack your thyroid. So there are many, many causes, plus there are inherited genetic vulnerabilities and it It’s not always low thyroid, sometimes it’s high thyroid, hyperthyroidism, like Graves’ disease, right? You can have antibodies Bill Gasiamis (13:01) Mm-hmm. Dr Hedaya (13:02) that are actually stimulating thyroid activity as well. Bill Gasiamis (13:06) Wow. The environmental toxins. we talking about all day, every day household use kind of environmental toxins? I imagine the external of the house, they’re kind of out of our control, right? We’ll talk about like, you know, like pollution or things that are associated to things that are caused that we don’t necessarily control, but internally inside the house or what we expose ourselves to that we can control. what would some of those environmental toxins Dr Hedaya (13:38) Well Bill Gasiamis (13:39) be? Dr Hedaya (13:40) so for example, you know, in your produce, you know, there are pesticides, or in the man made materials in your car or the man made materials in your home. Let’s say you bought a new home and you have, you know, some kind of synthetic floors or furniture with synthetic materials or materials that are natural that are treated with chemicals for various reasons. Those things all can be not everyone is, but many of them are called homes. hormone interruptors because they actually can change the way your hormones function. You know? So we’re the truth is we’re bathed in these chemicals. They’re everywhere. And very hard to escape them. The best thing you can do is kind of try to detox them using a healthy diet, a lot of crucifer vegetables and lots of vegetables, above ground vegetables that are grown in healthy soil. Without pesticides, organic preferably, right? and then there are supplements you can take, such as metagenics makes something called UltraClear Plus, which helps support the liver, and its detox functions. You know, some people are more vulnerable than others, but you know, these thyroid nodules you like you have, they’re very, very common now. Very common. And that’s you know. In large measure, I think these hormone interrupters that are interfering with how the the thyroid follicles in the thyroid gland are operating. Bill Gasiamis (15:13) Is it possible to have thyroid nodules and not know about it? I, I Dr Hedaya (15:18) Yeah. Bill Gasiamis (15:19) say that because I had nodules that were the size of a baseball, apparently in my throat that were growing inwards, that didn’t make a lump outside of my throat, which Dr Hedaya (15:33) Yeah. Bill Gasiamis (15:34) I was not aware of. And the way they found it was they did a chest X-ray after brain surgery because I wasn’t recovering well. to check my chest to see if there’s an infection. And they noticed a massive lump in my throat and my esophagus and my windpipe were pushed six centimeters. Dr Hedaya (15:52) Wow. Bill Gasiamis (15:53) I’m not sure what that is in inches. And they said to me, well, can you swallow? Can you breathe? Can you do it? And I was like, yeah, I’m all fine. There’s nothing wrong with my throat. But that was the first sign that there was something wrong with my thyroid before that. there was no sign of it. I ask that because either I’m totally oblivious or it is possible to have thyroid nodules and not know it. Dr Hedaya (16:23) Well, most people don’t know it. Now yours is so massive, but I think it’s kind of what you said is how it grew. If it grew towards your vocal cords or your laryngeal nerve or something, you would have had some pretty bad hoarseness or something like that. But it grew I guess backwards so it didn’t interfere that much. And I guess your s your body adapted gradually over time. You know, yes, it’s very possible for sure. Very common. Bill Gasiamis (16:49) And how would somebody interact with a general practitioner, for example, now to go through the process of understanding, A, their thyroid health and whether or not they have any nodules. Navigating Thyroid Health with Healthcare Providers Dr Hedaya (17:02) I mean in other words, given what we’ve talked about, how should they approach their doctor basically? Bill Gasiamis (17:07) Yeah. Dr Hedaya (17:08) I guess I would say go to AI, get a list of the symptoms of low thyroid or high thyroid or all of them, check them off. So then when you go to the doctor you have a list, check your temperature, check your pulse, although the doctor will should check that. And then you could say, look, I have these symptoms, or maybe you don’t have any. But if you do, you have these symptoms, and clearly thyroid hormone levels can affect the brain. And I’d like a TSH, a free T4, a free T3, and a reverse T3. That’s it. And if they Bill Gasiamis (17:45) Okay, perfect. Dr Hedaya (17:46) say, no, no, we don’t need to do that, you know, a lot of times what they do, they’ll just do a TSH. Or they won’t do the reverse T3. They don’t, unfortunately, look at the thyroid gland in a dynamic way. They say, the TSH is fine. If your thyroid was low, your TSH would go high. We don’t need to do the rest. But that’s not true. That’s not true at all. Because especially if you had a stroke, your pituitary function may be compromised. Your TSH may be fine or low and your low thyroid. As matter of fact, in the last interview, the case that I talked about, who referred me to you, she actually had a low TSH, but she had a very low, I think it was a free T4. Or free T3 or both, whatever it was, but she had too little thyroid hormone, and her pituitary couldn’t respond because of the stroke. Bill Gasiamis (18:37) understood. So that’s a great list of Dr Hedaya (18:37) So so be you have to be dogmatic and you say to the doctor, look Even put into even put into AI and say, look, if the doctor comes back to me and argues against these tests, what should I say? You gotta be prepared because the doctor will steamroll you. You know, that they only allow this, they only allow that, I’ll only do the free T4. Well, that doesn’t tell you how much has been converted to T3, free T3, and it doesn’t tell you, even if the free T3 is normal, that doesn’t mean you’re not overproducing thyroid and and dis you know, and neutralizing it with the reverse T three. So, you know I mean I I mean I think it’s s so important that a thorough look is is really important. If you have the symptoms, you know. Bill Gasiamis (19:22) I agree with you. That list of to-dos, I’m gonna put that on the show notes. People can go and get that list if they don’t wanna go into AI themselves or they haven’t got the time or whatever. They can just download it from there. And then they’ll be able to take that and begin a conversation with their general practitioner. What’s interesting is that I’m in Australia, you’re in the United States. My general practitioner is pushed back when a… when a patient will turn up and say, I have these tests? They’ll say, well, no, you don’t have any condition that is obvious that you need these tests. So it’s not covered. So you don’t need to do it. So my next suggestion to them is no problem. Order the tests and I’ll pay for them. Now it’s not ideal, but if you’re not going to do them for me and I need to know, cause it’s my health, I’m going to pay for them. So just tell me how much it is and I’ll find a way and I’ll make it happen and I’ll pay for it. So that’s another option. Dr Hedaya (20:17) Yeah. But if you go in with your symptom list, right, and you say, Well, that’s not true, because these are the symptoms, you know, that I have, here they are, right here. You can take a look, you know. And then the last thing I’ll say, this gets even more tricky, is the reference range, I’m sure in Australia, but certainly in the United States, the reference range basically is of the TSH, the pituitary home. Is 0.5 to 4.5, meaning you anywhere in that range and your TSH is normal. That is a bad reference range. And I know it to be a fact because I I I guess I won’t waste your time with it, but I did a study on a hundred people and with a very sensitive thyroid test called a TRH stimulation test. and I was able I hired a statistician to calculate this. And say, well, I don’t want to keep doing this test on everybody. What TSH predicts an abnormal TRH stimulation test? And he came back and said to me, Well, once the TSH is over 1.4, it starts to increase your odds of having an abnormal TRH stimulation. So I said, okay, so 1.4 TSH is my cutoff, right? That’s in my mind. I said, okay, that’s that’s my cutoff, that’s when I get suspicious. Later, several years later, a paper came out, a large, large study, called the NHANES Study, Nurses Health, and I’m not sure what it stands for. Thousands of people followed over many, many years, over decades, and they found the mean TSH in the US population is 1.4. So, right where I what right where my study found. So that means statistically, it is not. impossible to have the upper limit of the reference range being at four point five because statistically the upper limit is never more than two standard deviations. So even if your standard deviation is 1.4, which it can’t be, you you’re not going to reach 4.5, right? Unless you have a it’s called a bimodal distribution curve. If you have that, then you’d say, well, it it could be. But we don’t have that with thyroid. So that reference range is wrong. The upper limit of the reference range should be 2.5. And about half the endocrinologists in the United States believe that. And half say, no, no, no, don’t change it. So that’s another sticky point because, you know, easily people get a result and they’ll go to the doc and say, no, the reference range is 4.5. You’re normal. Then you could say, well, look, I have these symptoms, and they could do a literature search. What’s the normal reference point? What in in the N A N HANES N-H-A-N-E-S study? It’ll show you 1.4. and you could take be prepared to go to the doctor and say, Well, here’s a study that suggests that the reference range may be incorrect. and I have symptoms by the way. We don’t treat the lab, we treat the person. So could we give a trial? Just a trial, there’s no harm done, you know, trial. Let’s see let’s start at a very low dose. Let’s see how I feel. Maybe I’ll get better. I’ll come back in a month. Bill Gasiamis (23:45) Yeah, I love that. It’s really good advice, especially coming from someone who is a doctor who think is thinking on the same way as me, for example, the patient. Because that’s like a match made in heaven. And that’s so rare to be able to get that. Often, my challenge to my general practitioner was well, the reference range isn’t that average of a sick population, because it’s usually a sick population that comes to see you to get bloods. It’s It’s not the most healthiest people that come to see you to get bloods. And that’s kind of how I try to like start the conversation of convincing a general practitioner to do a test that they’re reluctant to do. And when I say they’re reluctant, I’m not in there every day. I’m not in there every week. And I’m not putting stress on the system to an extent where I’ve been over using the system. I’m not at all. in there once, twice a year, maybe, you so if I’m in once, twice a year, well, then, I’m not mucking around. Like I’ve come there to investigate something that I’m suspecting is wrong with me. It’s my body. I’m feeling something. had a bit of a look online. This is what I suspect. Don’t try and convince me out of my thinking or my instinct more better. Why don’t we just, work together to get to the bottom of it. If it is something it is, if it’s not, it’s not, and that’s okay. Not a big deal. I’m better to know. then not no, I think, you know, it’s better to be safe than sorry in my mind. Dr Hedaya (25:16) Yeah. I would I would only think only correction I would make is the reference ranges generally are made on normal populations. Now now the thing is who’s normal anymore? Number one. Number two, that’s a statistical norm that doesn’t tell you anything about your genetics. your vulnerabilities, it’s not an individualized statistic. I mean it’s it not an individualized thing. What’s your normal range? And are you out of your normal range? Nobody can answer that, right? Unless you had previous data before you were ill. And you say, well look, I’ve been running at a 1.1 for five years or 10 years and now I’m at 3.2. That’s a big change. Well, you know you’re stressed. Well yeah maybe but here are my symptoms. Always come back to your symptoms. Bill Gasiamis (26:11) Got it, got it. Dr Hedaya (26:12) No. Bill Gasiamis (26:13) You use the word stress just now and my general practitioner says, I might go in and some bloods might be out of whack or some things might be not feeling great. And he’ll say, are you stressed? And I’m like, well, I’m not stressed. like, I’m not stressed in any way that I can say is worse than normal. For example, I’m Dr Hedaya (26:35) Mm-hmm. Bill Gasiamis (26:36) just, you know, I’m attending to my clients at work. picking up the kids from school, I’m, you know, making sure the bills are paid. Like I’m just doing the normal things that I always Dr Hedaya (26:48) Right. Bill Gasiamis (26:48) do, which tend to be stressful. And somehow when we talk about stress, cortisol seems to come into the conversation. Dr Hedaya (26:57) Mm-hmm. The Role of Stress and Cortisol Bill Gasiamis (26:58) And I don’t know how to respond to a general practitioner who says to me, am I stressed? Because I’m not experiencing something extreme or dramatic. in the months before I came to see him. So can we have a conversation a little bit about stress, cortisol, what is stress, what is cortisol, are they linked? Tell me about that, give me your thoughts. Dr Hedaya (27:21) Okay. Okay, so this is a multi-layer system. Okay, it starts with your perception and your of a situation and the story you tell about you the story you tell yourself about the the situation and your need for control of a situation and as opposed to saying I’m in the flow of the universe and All right, this is you know, this is the way it is, and I’ll adapt to it. Not so easy by the way, but it’s a much healthier way because most things will not stress you. Now, pain, let’s say you stepped on a nail, you’re gonna have stress, okay? Totally stressful, etc. But there’s a a difference between pain and suffering. Most of our problem is suffering. Suffering is a result of thinking patterns. perspectives of yourself and the world and the future and blah blah blah. I could talk about that for a long time. And that is probably one of the most important places to intervene and to train yourself, etc. Now, once this thing is registered as stress, it goes through back to the hypothalamus and the pituitary where all those hormones are controlled, the hypothalamus and pituitary in the brain, now you’ve God forbid, you’ve had a stroke. Those things may be affected, therefore, those systems may not be working well. In that case, you may not be able to handle stresses that you used to handle. You may not you may not have those shock absorbers. So, how do you measure this? I think the way you measure it again are symptoms, and typically it would be low cortisol and low DHA, d DHEA, and low pregnenolone. And the symptoms would be a lot of fatigue, right? Maybe poor wound healing, muscle aches, body pains, getting sick more easily, cognitive slowing, depression, anxiety, extreme exhaustion, salt cravings, in unstable temperatures, you know, I would say yeah You know, th loss of appetite in severe cases, you know, dizziness on standing. Okay. So those are the low adrenal output things. Now how d how do you measure and again, you think you have a problem, go to an AI thing, make that list, check it off, whatever applies, and you know, work yourself up symptomatically and then ask well, okay, what what are the best tests here? What are the best test. Now the way I test it is I get morning I got a morning like eight to nine a.m fasting ACTH and cortisol. It’s gotta be in the morning around between eight and nine a.m. fasting. I also at the same time get a D, like David, H E A and a D H E A sulfate, and then I also get a pregnenolone. And if I think there’s any kind of sex hormone problem that I want to check, then I will check a free testosterone, FSH, LH, and The testosterone measures the free testosterone is very unreliable. So if it comes out low, you want to do it two more times to double check that. But the other measures are pretty reliable. And then you’ll you’ll know the other thing you can do is you could do something called a Dutch test, which is a urine test that’ll look at your cortisol through the day, or an adrenal saliva test. It’s ASI, alleval adrenal saliva index, the Dutch test. or the ASI, both good tests. and those will tell you what’s going on through the day. Like if you’re not sleeping, it could be because your cortisol high at night, you know. Wake up horrible or in pain. Could be because your cortisol is really low in the morning. Really low. You can’t even get out of bed, you know, can’t get going, right? So these are all all things that you can do to measure and then you can replace these hormones and That’s one thing to do. The other thing to do is to work on how you manage stress. There are millions of ways of doing that, right? From meditation to heart math to Bill Gasiamis (32:05) Mm-hmm. Dr Hedaya (32:06) yoga to you know, there’s just a lot a lot a lot of ways to Bill Gasiamis (32:10) Yeah, let’s go back for a moment and talk about testosterone because when I hear testosterone, I’m hearing you say to a male that I need to have testosterone in my body and at certain levels, et cetera. And sometimes it can fall out of whack and you need to get it tested. I had mine tested recently. It’s all good. But women also need testosterone. Tell me about that. Dr Hedaya (32:35) Yeah, so I was I was thinking of both male and female when I said it, Bill Gasiamis (32:38) Yeah. Dr Hedaya (32:39) because it’s it’s you know, women who are postmenopausal can have it’s much more common to have a low free testosterone loss of libido, you know. testosterone the studies which I’ve reviewed a few times, you know, there’s a debate does it affect the mind, the brain, you know. It seems to have an effect on well being, on vitality muscles, sex drive obviously, libido erectile function, brain cognitive function, some mood effects, etc. So I I think it’s important now i it it has to be managed in women as well as men. You know, in in women testosterone is a step on the way to estrogen as it is in men, right? And in the metabolism, right? So it it should certainly be assessed in everybody. Bill Gasiamis (33:39) Yeah. And estrogen, mentioned estrogen. Now, one of them in my mind, it seems to be more associated again to women, estrogen, especially. And, and then men also have estrogen, need estrogen. Dr Hedaya (33:55) Men also have estrogen. I haven’t studied it so I couldn’t tell you, but I imagine it’s doing something. it probably turns men into better leaders after they’re fifty, is my guess. Let Bill Gasiamis (34:08) more emotionally intelligent. Dr Hedaya (34:10) more emotionally intelligent, less testosterone, you know. You know, I I I Bill Gasiamis (34:15) You know what? That’s a good theory. We’ll run with that for now. I might relate to that, know, who knows. Dr Hedaya (34:22) Yeah. I I think Bill Gasiamis (34:24) Awesome, awesome, so… Dr Hedaya (34:24) Yeah, so w for for women on estrogen, it depends, you know, who are you assessing? Are you that’s a whole complex subject, you know. Is it a young woman who’s menstruating? Does she have premature ovarian failure, endometriosis, ovarian cysts, insulin resistance, they all kind of travel together, methylation problems, they travel together. is it someone who’s perimenopausal where she’s starting to lose progesterone and getting a lot of PMS? That’s pretty easy. You can replace the progesterone. Is it postmenopausal a woman who’s just kinda lost the estrogen, lost the progesterone? You know, if there’s a family history of cognitive decline or dementia or something like that, there’s great evidence that transdermal estrogen and some oral progesterone bio bioidentic, not synthetic, is great and reduces the risk for lots of disorders later in life for women. You know. So there’s a whole you know, there’s a whole way of working all that up, depending on who who you’re looking at. But very important. Now so the let me Bill Gasiamis (35:31) Yeah, I love it. Yeah. Dr Hedaya (35:34) say this. The important thing here, and this is maybe the most important thing. Someone’s had a stroke, they’re obviously tremendously stressed. You have to look at all the hormones. You can’t the brain is a hormonal organ. It’s an immune organ. It’s a neurological organ. I used to teach psycho, neuro, immuno, and the chronology at Georgetown for a number of years. Okay? And the brain and hormones, you can’t separate it. So if the brain is under stress, the hormonal axes are under stress, and there’s not one hormonal axis when it’s abnormal that cannot cause neurological or psychiatric problems. Okay? So you must, as part of the work of anyone who’s had stroke. You must look at the endocrine, the hormonal axis. You know, you must look at it. Why? Because if you’re trying to recover from a stroke and you don’t have adequate hormones, it’s gonna be much, much harder. Much, much harder. Right? But Bill Gasiamis (36:37) Peace. Dr Hedaya (36:38) if you have if you have the the hormones at good levels, okay, now the the brain has that. If it has its nutrients, it has that, you know, okay, now it can do something, you know. What happens, think about it this way. What happens in adolescence? The brain is being rewired, the body’s growing, brain is rew being rewired. Where are the hormones? The hormones are skyrocketing. They’re necessary for the rewiring. You had a stroke, you’re trying to rewire brain, you gotta have adequate hormones. Bill Gasiamis (37:10) I love it. This is the thing that people miss. You know, we talk about the gap in stroke recovery. Acute phase gets handled Dr Hedaya (37:19) That’s Bill Gasiamis (37:19) 99 % of the time really well. People get patched up and they get sent home in some kind of alive state, whether they are fully functional Dr Hedaya (37:27) Yeah. Bill Gasiamis (37:28) or working towards it or whether they are less functional and working towards being more functional, like some kind of stage Dr Hedaya (37:35) Mm-hmm. Bill Gasiamis (37:36) of you’re alive and you’re good enough to go home. And then there’s no information after that. So how do we assess address? How, what do we know? What do we not know that we need to know? And this is kind of what this conversation is, right? It’s like, okay, here’s Dr Hedaya (37:53) Yeah. Bill Gasiamis (37:53) a whole bunch of things we’ve just discussed. There might have been things that you heard for the first time. Don’t let that, get in the way of your curiosity and investigate the thing that pricked your ears up, whether it was a symptom that Dr. Hedaya mentioned and just do a little bit more work in understanding what that is, take that to your general practitioner and begin the conversation of taking responsibility for your recovery. And in my mind, like there’s gotta be like a foundational thing that people can do to intervene that doesn’t cost most of the time anything extra. And that helps encourage and nourish the brain in overcoming these challenges, but then has the a cascade effect of having the same positive outcome on all the other organs and hormones. And that to me is nutrition. So like, if you’re, if you would suggest to somebody how they might start thinking about their nutrition as opposed to what they might have been doing before stroke, how do you begin that conversation? And what are the two or three fundamental things that they need to consider? about nutrition. Nutrition’s Impact on Brain Recovery Dr Hedaya (39:11) Okay, so If it doesn’t grow that way, don’t eat it. I never saw a bread tree. I didn’t see an ice cream tree or a Twinkie tree. Okay. So if it doesn’t grow that way, don’t eat it. Balance your plate. Balance your plate. And actually our coach, Caroline Hade, is putting out an ebook. I don’t know, should be out at a week or two or three weeks. It’s like, I don’t know, four or five dollars or something. and that will tell you exactly how to balance your plate. and then I would say very important to have three meals and maybe, depending on your how insulin resistant you are, maybe additionally two snacks. and per day, but keep your calories you don’t want to be overweight, okay, because if you’re overweight, you know, that’s a That’s its own risk factor for brain problems, right? but you can’t lose weight in a day, you’re stressed, you’re hungry, you’re tired, you eat the carbs, you know, everybody struggles with that. But that that is one of the biggest enemies of eating eating eating these processed carbs that we all love is one of the biggest enemies of your health. One of the biggest enemies of your health for sure. Bill Gasiamis (40:35) Okay, there are some great resources that people can again look into how to eat to heal the brain. And we didn’t have to have a deep conversation about that. But I love Dr Hedaya (40:45) Mm-hmm. Bill Gasiamis (40:45) what you said about balancing the plate. And if it didn’t grow that way, don’t eat it. It’s such a simple thing. If it comes in a packet on a shelf in a supermarket with all fancy pictures Dr Hedaya (40:59) Yeah. Bill Gasiamis (41:00) and stickers and a list of ingredients, like it’s probably not nutritional. of food. It’s probably something that’s going to make inflammation worse. It’s probably something that’s going to give you the type of energy that is not helpful. It’s probably going to have a whole bunch of other things. And that’s kind of my approach to healing and recovering my brain. It’s one of the first things I did was just look at my nutrition, immediately stop smoking and drinking. mean, I know it should go without saying, but sometimes you have to have a stroke for it to actually sink in and make sense. and don’t have any alcohol at all. I’m talking about forever if you can, but I didn’t have alcohol Dr Hedaya (41:46) Yeah. Bill Gasiamis (41:47) for at least the first four or five years. And now in the next five years or so, maybe I had one glass per year, just because I was, in an event where it was, everyone was drinking and it was almost necessary to have sip or half a sip or act as if I was drinking. So with that, I think we’ll wrap up this conversation today. There’s been a lot for people to digest, go back and listen to it a second time. And a third time that we have some resources in the show notes. And Dr. Hedaya, thank you for joining me again. And I look forward to our conversation that’s coming up in a few weeks time where we’re going to talk about toxin load and neuroplasticity. Dr Hedaya (42:29) Beautiful. Thanks so much for the opportunity, Bill. I hope I hope people get something out of this and they pursue what they need to pursue. Bill Gasiamis (42:36) Well, that’s a wrap on this conversation with Dr. Robert Hedeya. If there’s one thing to take from today’s interview, it is this. The brain is a hormonal organ and recovery isn’t just about the brain healing in isolation. Thyroid, cortisol, testosterone, estrogen, all of it is connected, and all of it is worth checking if your recovery has plateaued in ways that don’t quite make sense. Dr. Hadea’s free PNIE questionnaire is linked in the show notes. Download it, work through it, and take it with you to your next GP visit. If you want to go deeper on the thyroid piece specifically, go back and listen to the earlier episode with Dr. Elena Zinkov on stroke fatigue and thyroid. And if you missed it, the first conversation with Dr. Hedeya on photobiomodulation is a great companion to this one. if this episode has helped you, share it with someone who needs to hear it. That’s genuinely the best way to help this show reach more survivors. My book, The Unexpected Way That a Stroke Became the Best Thing That Happened, is available at recoveryafterstroke.com/book. And if you’d like to support the show financially, you can do so at Patreon by going to patreon.com/recoveryafterstroke. Until next time, take care of yourself and don’t assume it’s just a stroke. The post Hormones, Fatigue, and the Brain: Dr. Robert Hedaya Returns appeared first on Recovery After Stroke.

Was ist eigentlich aus Project No Time geworden? Nach der Challenge Roth ziehen Nick und Nils eine ehrliche Bilanz: Aus lockerem Training ohne Zeitdruck wurde in den letzten Wochen doch wieder ein Alltag, der sich um Einheiten, Heat-Training, Ernährung und Regeneration drehte. Die große Frage: Kann eine Langdistanz überhaupt ein Hobby bleiben – oder übernimmt sie zwangsläufig das ganze Leben?Außerdem sprechen die beiden über Perfektionismus und Trainings-Gamification, die Balance zwischen Sport, Familie und Beruf sowie den berüchtigten Ironman Blues nach dem großen Rennen. Warum weniger Training nicht automatisch Formverlust bedeutet, weshalb neue Ziele und lockere Bewegung helfen können – und warum eine Halbdistanz manchmal einfach die bessere Idee ist. Zum Abschluss gibt's die Race-Prediction für den Ironman Lake Placid und die Frage, wie realistisch Freds nächster Schritt in Richtung Kona ist. Werbung: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠PUSHING LIMITS CLUB⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Deine All-in-One Trainingsapp für Triathlon, Radfahren und mehr! Alles, was du für dein Training brauchst – immer griffbereit.

Neurologist Dr. David Perlmutter Explains Brain Inflammation and Alzheimer's Risk Your brain has its own immune system, and when it turns against you, it becomes the hidden driver behind Alzheimer's, Parkinson's, depression, and even long COVID. This episode hands you the science to recognize it early and reverse it. Get Dr. Perlmutter's new book Brain Defenders: https://drperlmutter.com/books/brain-defenders/ Host Dave Asprey sits down with Dr. David Perlmutter, a board-certified neurologist and six-time New York Times bestselling author whose work sits at the intersection of neurology, nutrition, and brain health. He is a Fellow of the American College of Nutrition, serves on its Board of Directors, and sits on the Editorial Board of the Journal of Alzheimer's Disease. His books, including the number one bestseller Grain Brain, span 32 languages and have sold over a million copies, and his upcoming release, Brain Defenders, explores the pivotal role of microglia, the brain's immune cells, in protecting, repairing, and reprogramming the brain for lifelong resilience. Dave and Dr. Perlmutter break down how microglia, the brain's resident immune cells, shift from a supportive state into a destructive one called M1, and why this shift, not amyloid plaque, may be the real driver of Alzheimer's, Parkinson's, and other neurodegenerative conditions. They dig into why the leading amyloid-clearing drugs fail to improve cognition, what a landmark JAMA study revealed about reversing cognitive decline through lifestyle intervention alone, and why a single daily serving of ultra-processed food raised Alzheimer's risk by 13 percent in a 12.7 year study. They also cover new research on GLP-1 drugs and brain inflammation, the surprising role of gum disease and oral bacteria in dementia risk, and why 40 hertz light therapy is emerging as a low-cost tool for clearing brain plaque and calming neuroinflammation. You'll Learn: Why the shift from supportive to destructive brain immune cells may be the true root cause of Alzheimer's and Parkinson's Why leading Alzheimer's drugs fail to improve cognition, and what the original research behind the amyloid hypothesis actually showed How one daily serving of ultra-processed food raises Alzheimer's risk, and what a landmark lifestyle intervention study found instead Whether GLP-1 drugs help or harm brain inflammation, based on new Parkinson's and Alzheimer's trial data How gum disease and oral bacteria are linked to dementia, and simple daily habits that reduce that risk Why 40 hertz light therapy is emerging as a tool to clear brain plaque and calm neuroinflammation How ketones, DHA, and metabolic health protect the brain after head injury Thank you to our sponsors! - Beyond Wonderland Conference | Oct 13 - 14, 2026. Get your ticket now at wonderlandconference.com. - ZenBud | Dave's Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount. - Pique | Head over to Piquelife.com/Dave to get 20% off your order. That's P-I-Q-U-E life dot com slash DAVE - PredictiveMind™ | Get your Brain Pattern Mapping report at predictivemind.io/dave and use code DAVE for 10% off. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: microglia, brain inflammation, Alzheimer's prevention, Parkinson's disease, amyloid hypothesis, neurodegeneration, GLP-1 drugs, semaglutide, ultra-processed food, gum disease and dementia, oral microbiome, 40 hertz light therapy, ketones, DHA, mitochondria, brain fog, long COVID, David Perlmutter, Brain Defenders, Grain Brain, functional medicine, biohacking, longevity, neuroplasticity Resources: • Get Dr. Perlmutter's New Book Brain Defenders: https://drperlmutter.com/books/brain-defenders/ • Learn More About Dr. Perlmutter's Work At: https://drperlmutter.com/ • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15? • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 00:40 – Intro 02:38 – Ultra-Processed Foods 06:34 – Are Carbs Bad? 08:48 – Alcohol & Brain Health 12:28 – Microglia & Inflammation 24:37 – Head Injury & Recovery 29:27 – Oral Bacteria & Dementia 34:08 – GLP-1s & Brain Inflammation 40:20 – 40 Hertz Light Therapy 48:35 – Air Pollution vs. Lead 50:27 – David's Closing Truth See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Immune Regulation, Omega-3 Nuance, and Himalayan Tartary Buckwheat with Dr. Austin Perlmutter, chief science officer of Big Bold Health. He details immune regulation as a nuanced, multidimensional system shaped by diet and lifestyle rather than simple “boosting.” Perlmutter explains Big Bold Health's focus on immunometabolism, educating about immune complexity, and conducting studies on nutraceuticals, including use of CGMs and clinical trials. He discusses why eating fish often outperforms refined fish-oil supplements, noting conventional processing (heat, bleaching, deodorizing, esterification) and loss of other lipids and nutrients. Perlmutter highlights specialized pro-resolving mediators (resolvins, protectins, maresins) and vitamins A and D as potentially better preserved in minimally processed oils, and reviews typical omega-3 intake and target ranges. The conversation also covers immunosenescence/inflammaging and Big Bold Health research on sprouted Himalayan Tartary Buckwheat, its high polyphenols (rutin, quercetin), microbiome effects, and studies including epigenetic aging clocks and brain outcomes.

Wie jedes Jahr kommt heute die Campingplatz-Challenge-Roth Edition. Dieses mal mit Stammgast Jan Stratmann. Wir sprechen über sein Hitze Rennen, dem Ironman Frankfurt und mit Jan Orakeln wir, wie das Renne in Roth am Sonntag ausgehen könnte.Werbung: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠PUSHING LIMITS CLUB⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Deine All-in-One Trainingsapp für Triathlon, Radfahren und mehr! Alles, was du für dein Training brauchst – immer griffbereit.

Omega-3 fatty acids remain one of the most researched and widely recommended nutrients for supporting overall health. On this episode, Jared welcomes Nicole Gitlin from Nordic Naturals to explore the science behind EPA and DHA, the differences between fish oil, cod liver oil, and krill oil, and how omega-3s support healthy brain function, cardiovascular wellness, inflammation balance, mood, and healthy aging. They discuss research-backed dosing strategies, why quality matters when choosing an omega-3 supplement, and how omega-3s may benefit children, adults, and even pets. Jared also shares why omega-3s remain a cornerstone of his Vital 5 protocol and why consistent use may be one of the most important nutritional investments you can make for long-term wellness. Plus, learn about Nordic Naturals' efforts to support cleaner oceans through their Coastal Cleanup initiative.Products:Vital 5 Omega-3 + AntioxidantsNordic Naturals Omega-3 ProductsVisit the podcast website here: VitalityRadio.comYou can follow @vitalitynutritionbountiful and @vitalityradio on Instagram, or Vitality Radio and Vitality Nutrition on Facebook. Join us also in the Vitality Radio Podcast Listener Community on Facebook. Shop the products that Jared mentions at vitalitynutrition.com. Let us know your thoughts about this episode using the hashtag #vitalityradio and please rate and review us on Apple Podcasts. Thank you!Just a reminder that this podcast is for educational purposes only. The FDA has not evaluated the podcast. The information is not intended to diagnose, treat, cure, or prevent any disease. The advice given is not intended to replace the advice of your medical professional.This podcast is produced by DrTalks.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://drtalks.com/podcast-service/⁠

Early signs of dementia can show up years before a diagnosis. Discover 31 scientifically proven dementia prevention strategies designed to preserve cognitive function and support long-term brain health.0:00 Introduction: What is dementia?0:42 How to not get dementia3:03 Stomach acid and dementia signs5:40 DHA to improve cognitive function7:20 Aluminum and brain function9:45 Gum health and dementia11:04 Hypoxic training for dementia prevention14:51 Keto and intermittent fasting for dementia prevention16:16 Genes and dementia

Broadcast from KSQD, Santa Cruz on 6-25-2026: Dr. Dawn devotes the show's opening to ivermectin for COVID. She walks through critical thinking principles—considering the source, cross-verification, and recognizing self-interested claims—before reviewing the evidence. The most-cited 2021 Bulgarian study of 300 people showing 77% reduction lacked accessible methods, and larger trials capable of detecting even small benefits failed to confirm efficacy. On safety, the standard 12mg parasitic dose every few weeks is well-tolerated due to the blood-brain barrier and efflux pumps that keep ivermectin out of the brain, but daily long-term dosing has caused encephalopathy, liver and kidney damage, and birth defects. Critical drug interactions—macrolide antibiotics, verapamil, proton pump inhibitors, and beta blockers—disable the efflux mechanism, and high-fat meals increase absorption 2.5-fold. Dr. Dawn shares two inflammation formulas calculable from any CBC. The Systemic Inflammatory Index (neutrophils × platelets ÷ lymphocytes) flags runaway inflammation: 200-500 is good, above 900 warrants investigation and correlates with worse stroke outcomes and rising tumor burden. The SIRI (neutrophils x monocytes ÷ lymphocytes) detects chronic tissue inflammation and early innate immune activation: below 500 is good, above 1500 indicates trouble and correlates with cardiovascular mortality and arterial plaque from M1 macrophage activity. Dr. Dawn shares two takeaways from the Institute for Functional Medicine annual conference: in patients at high cardiovascular risk by cholesterol, each gram daily of combined EPA/DHA produces a 9% risk reduction, with bruising as the dose-limit signal. Additionally, a 15-minute walk within 30 minutes of a meal nearly eliminates postprandial inflammation. An emailer asks whether an endocrinologist's claim that vitamin D leaches calcium from bones is true. Dr. Dawn confirms that very high vitamin D (above 150 nanograms, with concern starting above 90) elevates 1,25-vitamin D, which stimulates osteoclast formation and increases C-telopeptide markers of bone breakdown. A crowdsourced question asks how histamines work in women. Dr. Dawn explains histamine functions as a CNS neurotransmitter promoting alertness, wakefulness, and pain perception (deficient in narcolepsy), and as a GI signal driving acid secretion, motility, and visceral sensation. Gut bacteria can convert histidine to histamine, and fish left to spoil can trigger anaphylactic-like reactions from accumulated bacterial histamine. She notes stomach acid treatments Tagamet and Zantac are H2 blockers rather than the more familiar H1 antihistamines, and confirms histamine correlates with hormones but not particularly with minerals. A crowdsourced question on B vitamins for women in their mid-twenties prompts Dr. Dawn to recommend prenatal vitamins for those who might become pregnant, and B100 complex with calcium taken with a little apple cider vinegar for those on restricted diets or eating mostly fast food. Another question asks about chest versus belly breathing. Dr. Dawn explains babies demonstrate proper diaphragmatic breathing (belly protrudes on inhalation) while accessory muscle use signals fight-or-flight—or pneumonia in a non-crying infant. Chest breathing raises adrenaline; belly breathing calms it in adults. How do I stop compulsive scratching? Dr. Dawn explains neurodermatitis has its own ICD-10 code alongside compulsive nail-biting and hair-pulling, and it is diagnosed by sparing of unreachable areas like the mid-back between shoulder blades. Treatment includes nail clipping, lubricants, covering scabbed areas, and Prozac—which uniquely among antidepressants has a secondary indication for neurodermatitis. Zurich researchers combined immature human nerve cells with magnetic nanoparticles to create 6-micrometer NPC bots that can be magnetically positioned at spinal cord injury sites and then triggered by pulsatile magnetic stimulation to mature into nerve tissue. Mice with severed spinal cords regained movement and brain-muscle electrical signals by day 34 after daily 30-minute treatments. A study of 15,000 people with myalgic encephalomyelitis/chronic fatigue syndrome identified eight genetic regions distinguishing them from controls. Two relate to immune response to infection—consistent with the post-infectious onset many sufferers describe, including roughly half of long COVID patients—and others link to the nervous system and chronic pain. Dr. Dawn frames ME-CFS as an immune system stuck in the "on" position, unable to brake against an enemy that is long gone. An emailer asks about prostate biopsy approaches. Dr. Dawn explains the new transperineal biopsy (through skin between scrotum and anus) reduces post-biopsy infection from 1.5% to near zero and eliminates prophylactic antibiotics, though it requires more anesthesia and time. Cancer detection rates match the transrectal approach when both use MRI targeting, and she expects the transperineal approach to become standard.

Fish Oil Supplements And Alzheimer's-Related Decline A two-year randomized, double-blind, placebo-controlled trial led by researchers at USC tested whether 2,000 mg of DHA fish oil daily could slow Alzheimer's-related brain changes in 365 adults ages 55–80 who rarely consumed fish and had at least one Alzheimer's risk factor. Researchers confirmed the supplement reached the brain by measuring a roughly 17% increase in cerebrospinal fluid DHA after six months. Despite successfully increasing brain DHA levels, participants taking fish oil showed no significant improvements in memory, global cognitive function, or hippocampal volume compared to placebo after two years. Host Dave Asprey explains why raising a single biomarker doesn't always translate into better brain performance, why nutrition works differently inside a complete dietary pattern than as an isolated supplement, and what this study means for anyone relying on fish oil as an Alzheimer's prevention strategy. Sources: https://medicalxpress.com/news/2026-06-fish-oil-supplements-alzheimer-decline.pdf https://www.cnn.com/2026/06/18/health/omega-3-fish-oil-algae-supplement-wellness ~~ DASH Diet Showed the Strongest Link to Long-Term Brain Health Researchers from Harvard analyzed dietary data from 159,347 participants across three long-running U.S. health studies to examine how eating patterns influence cognitive aging. Participants completed dietary questionnaires every four years over several decades, allowing investigators to compare six healthy dietary patterns, including the DASH and Mediterranean diets. While all six were associated with better cognitive health later in life, adherence to the DASH diet produced the strongest association, with participants showing roughly a 40% lower risk of subjective cognitive decline and stronger performance on objective cognitive testing. The protective relationship was strongest when healthy eating habits began during midlife. Host Dave Asprey breaks down why blood sugar control, lower inflammation, and healthier blood vessels may be the real drivers behind long-term brain resilience, and why your dietary choices in your 40s and 50s may have an outsized impact on cognitive aging decades later. Sources: https://jamanetwork.com/journals/jamaneurology/article-abstract/2845466 https://www.health.harvard.edu/diet-and-nutrition/harvard-study-six-healthy-diets-linked-with-better-long-term-brain-health https://www.eurekalert.org/news-releases/1117225 ~~ Scientists Identified an Ancient Brain Circuit That Filters Distractions Johns Hopkins researchers discovered a small population of inhibitory neurons within an evolutionarily ancient brainstem region that appears to control selective attention by determining which sensory information deserves focus and which distractions should be ignored. Mice trained on visual attention tasks consistently ignored irrelevant stimuli until researchers temporarily silenced these neurons, causing even weak distractions to hijack their attention while leaving vision and movement otherwise unaffected. Similar brain circuits exist in birds, reptiles, and other vertebrates, suggesting this attentional filtering system evolved long before the modern human cortex. Host Dave Asprey explains why attention may depend on much older brain circuitry than previously believed, how this discovery could reshape our understanding of ADHD and autism, and why future therapies may target the brainstem instead of the prefrontal cortex. Sources: https://www.sciencedaily.com/releases/2026/06/260624025426.htm ~~ Nearly Half of Older Adults Improved With Age Instead of Declining A Yale-led study followed 11,340 adults age 65 and older for up to 12 years using repeated measurements of cognition and walking speed to better understand how aging changes over time. Rather than finding universal decline, researchers discovered that 45% of participants improved in either cognitive function, physical performance, or both. Nearly one-third experienced measurable cognitive improvements, while over one-quarter improved physically. Researchers also found that participants with more positive beliefs about aging were significantly more likely to improve, even after accounting for education, chronic illness, depression, and other health factors. Host Dave Asprey explores why expectations about aging may become biologically embedded, why decline is far less inevitable than conventional medicine often assumes, and how mindset may directly influence healthy longevity. Sources: https://www.sciencedaily.com/releases/2026/06/260620100428.htm ~~ Glyphosate May Be Contributing to Antibiotic-Resistant Superbugs Researchers publishing in Frontiers in Microbiology examined 102 bacterial strains collected from hospitals, agricultural land, and protected wetlands to investigate whether glyphosate exposure contributes to multidrug antibiotic resistance. Hospital bacteria demonstrated extensive resistance to both antibiotics and glyphosate, while even bacteria living inside protected nature reserves displayed measurable glyphosate resistance despite no direct herbicide application. Genetic analysis suggested resistant bacterial strains may move between agricultural environments and hospitals through shared waterways and sediments. The researchers argue pesticide safety testing should also evaluate whether chemicals encourage antibiotic resistance, one of the world's fastest-growing public health threats. Host Dave Asprey explains why environmental toxins may have unintended effects on the human microbiome, how herbicides could influence antimicrobial resistance beyond farming, and why environmental biology increasingly belongs in conversations about human health. Sources: https://www.sciencedaily.com/releases/2026/06/260620100434.htm https://www.openaccessgovernment.org/common-weedkiller-glyphosate-linked-to-rise-in-superbugs-scientists-warn/207515/ ~~ Butterflies That Barely Age Could Unlock New Longevity Pathways Researchers from the University of Bristol found that Heliconius butterflies live dramatically longer than closely related butterfly species while aging much more slowly. In one comparison, Heliconius hewitsoni survived up to 348 days, while a closely related species lived only 14 days. Unlike most butterflies, Heliconius feed on pollen throughout adulthood, providing amino acids that help preserve muscle function and physical performance with age. However, even when pollen was removed, these butterflies still significantly outlived their relatives, suggesting evolved genetic and metabolic mechanisms also contribute to their exceptional longevity. Host Dave Asprey explores why nature continues to provide unexpected models for slowing biological aging, what scientists hope to learn from species that naturally maintain function over time, and how comparative biology may uncover entirely new pathways for extending human healthspan. Sources: https://www.sciencedaily.com/releases/2026/06/260622014302.htm ~~ This episode is designed for biohackers, longevity enthusiasts, and high-performance listeners who want mechanism-level insights into omega-3 supplementation and Alzheimer's prevention, nutrition strategies for preserving cognitive health, newly discovered brain circuits controlling attention, the surprising biology behind healthy aging, environmental drivers of antibiotic resistance, and what one remarkably long-lived butterfly can teach us about extending healthspan. Host Dave Asprey connects randomized clinical trials, large population studies, neuroscience discoveries, microbiology research, and evolutionary biology into practical frameworks for improving brain performance, resilience, and longevity. New episodes every Tuesday, Thursday, Friday, and Sunday. Keywords: fish oil Alzheimer's study, DHA supplements memory, omega-3 brain health, DASH diet cognition, dementia prevention diet, cognitive decline nutrition, selective attention brainstem, focus neuroscience, ADHD brain research, positive aging beliefs, healthy aging study, cognitive improvement older adults, glyphosate antibiotic resistance, superbugs glyphosate, environmental toxins microbiome, butterfly longevity research, Heliconius aging, longevity science, biohacking news 2026, Dave Asprey, The Human Upgrade Thank you to our sponsors! - Suppgrade Labs | Grab your DAKE and Minerals 101 duo at shopsuppgradelabs.com and use code DAVEPOD for 15% off today - Neuronic | Go to www.neuronic.online Code DAVE for $100 off - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE Resources: • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Intro 00:18 – Story #1 Fish Oil 02:31 – Story #2 DASH Diet 03:49 – Story #3 Brain Stem Attention Filter 05:59 – Story #4 Cognitive Decline Lies 08:24 – Story #5 Glyphosate 10:16 – Story #6 Butterfly Lifespan Research 12:16 – Biohacking Criticism Response See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

When Jenna Fuhrman got pregnant, her prenatal appointments covered tests, screenings, and medications — but barely touched the factor with the deepest influence on fertility, pregnancy, and her child's lifelong health: what she eats. In this episode, she and her father, Dr. Joel Fuhrman, dig into what the research actually says. Most physicians get little nutrition training, even as the science on prenatal nutrition keeps growing — which means parents who want to give their child the best possible start often have to learn this for themselves. Joel and Jenna cover what to eat before conception and through all nine months, and why small dietary shifts can make a lasting difference for both mother and baby. What you'll learn: The surprising link between a father's diet, sperm quality, and miscarriage risk — why this isn't only about the mother Why what both parents eat before conception may shape fertility, miscarriage risk, and a child's long-term health Getting folate from greens and beans, and how it differs from synthetic folic acid Why Dr. Fuhrman recommends algae-derived DHA and EPA over fish during pregnancy Why ferritin testing — not just standard anemia screening — can reveal more about iron status Managing morning sickness and food aversions with small, frequent portions of nuts, seeds, and beans, without losing nutrient density Supporting healthy blood pressure and blood sugar through pregnancy Why a high-animal-protein diet may not be the optimal approach, and how plant protein supports a healthy baby Whether you're trying to conceive, currently pregnant, or planning ahead, this episode offers practical, science-backed guidance for nourishing both mother and baby.

He carried two copies of ApoE4, the highest genetic risk factor for Alzheimer's disease, went through medical school knowing exactly what his LDL of 700 meant, decided the experts were wrong, and then published the case report to prove it. In this episode, Louisa sits down with Dr. Nick Norwitz, PhD researcher and metabolic scientist, for one of the most scientifically dense conversations on brain health, cholesterol biology, and Alzheimer's prevention ever recorded on this show. They cover why the phospholipid form of DHA reaches the brain more effectively than standard fish oil, how ApoE4 carriers burn through omega-3s differently and what to do about it, the lithium orotate data that sold out supplement shelves worldwide, and why GSK-3 beta, the enzyme that phosphorylates tau, may be the most under appreciated target in Alzheimer's research today. Then Dr. Nick Norwitz lays out the case that challenges the "LDL is always the enemy" consensus: why metabolically healthy individuals may not benefit from aggressive lipid-lowering therapy, what his viral coronary CT angiogram showed after seven years of 700+ cholesterol, why the EZPAVE trial headlines don't hold up under scrutiny, and what GLP-1s are doing inside the brain completely independent of weight loss. You'll also hear about the sardine diet experiment, the omega-3 thermogenesis connection, ketones as misfolded protein clearance agents, creatine for depression, retatrutide and PCSK9, BPC-157 risks, and what Dr. Nick Norwitz believes is coming in Alzheimer's gene therapy within the next decade. *Reduce your risk of Alzheimer's with my science-backed protocol for women 30+:*https://go.neuroathletics.com.au/youtube-sales-page Subscribe to The Neuro Experience for evidence-based conversations at the intersection of brain science, longevity, and performance. _____ *TOPICS DISCUSSED*(00:00:00) Intro: The ApoE4 Paradox and the Case Report That Broke the Internet (00:00:57) Why Standard Omega-3 Supplements Fail and What to Take Instead (00:05:13) DHA and the Phospholipid Carrier: How It Crosses the Blood-Brain Barrier (00:10:19) ApoE4 Explained: Risk, Genetics, and Why Nick Is Optimistic (00:17:38) Why ApoE4 Carriers Burn Through DHA Faster and Need More (00:20:31) Women, Omega-3s, Menopause, and Brain Insulin Resistance (00:21:41) Statins, Sex Differences, and the DHA-Blood Sugar Connection (00:26:01) Statins and Dementia: What the Data Actually Say (00:32:24) Tau, GSK-3 Beta, Lithium Orotate, and Targeting Alzheimer's Pathology (00:42:19) The Glymphatic System, 40Hz Devices, and Sleep as Brain Clearance (00:45:21) Gene Editing, Prime Editing, and the Future of ApoE4 Therapy (00:49:33) Nick's Case Report: 700 LDL, Zero Plaque, and Seven Years of Data (00:55:10) The EZPAVE Trial: Why the Headlines Don't Hold Up (01:00:33) KetoneIQ: Ketones for Brain Energy and Focus (01:01:29) Cheers Health: Supporting Liver Function and Cognitive Recovery (01:03:54) If Not LDL, What Causes Heart Disease in Metabolically Healthy People? (01:12:05) The Oreo Experiment and the Sardine Diet: Self-Experiments in Metabolism (01:19:10) Ketones, Women's Brains, and Clearing Misfolded Proteins (01:21:08) The Full Brain Health Protocol: Omega-3s, Creatine, NAD, Lithium, and More (01:24:01) GLP-1s for the Brain: Independent of Weight, Targeting Amyloid and Tau (01:25:28) Peptides: BPC-157 Risks, Retatrutide, MOTS-c, and What's Worth Watching (01:29:02) Why Nick Is Controversial And Why He Doesn't Mind _______ *Thank you to our sponsors*Fenix Health Science: fenixhealthscience.com Use code NEUROEXPPulsetto: https://pulsetto.tech/pages/NEURO or use Code NEURO for some off your orderFunction Health: https://www.functionhealth.com/louisanicolaBASED Bodyworks: https://basedbodyworks.com/ and use code NEURO for 20% offKetoneIQ: https://ketone.com/NEURO for 30% OFFCheers Health: https://CheersHealth.com/NEURO or use code NEURO for 20% off _______ I'm Louisa Nicola - clinical neurophysiologist - Alzheimer's prevention specialist - founder of Neuro Athletics. My mission is to translate cutting-edge neuroscience into actionable strategies for cognitive longevity, peak performance, and brain disease prevention.If you're committed to optimizing your brain- reducing Alzheimer's risk - and staying mentally sharp for life, you're in the right place. Stay sharp. Stay informed. Join thousands who subscribe to the Neuro Athletics Newsletter → https://bit.ly/3ewI5P0Instagram: https://www.instagram.com/louisanicola_/Twitter : https://twitter.com/louisanicola_ Learn more about your ad choices. Visit megaphone.fm/adchoices

He carried two copies of ApoE4, the highest genetic risk factor for Alzheimer's disease, went through medical school knowing exactly what his LDL of 700 meant, decided the experts were wrong, and then published the case report to prove it. In this episode, Louisa sits down with Dr. Nick Norwitz, PhD researcher and metabolic scientist, for one of the most scientifically dense conversations on brain health, cholesterol biology, and Alzheimer's prevention ever recorded on this show. They cover why the phospholipid form of DHA reaches the brain more effectively than standard fish oil, how ApoE4 carriers burn through omega-3s differently and what to do about it, the lithium orotate data that sold out supplement shelves worldwide, and why GSK-3 beta, the enzyme that phosphorylates tau, may be the most under appreciated target in Alzheimer's research today. Then Nick lays out the case that challenges the "LDL is always the enemy" consensus: why metabolically healthy individuals may not benefit from aggressive lipid-lowering therapy, what his viral coronary CT angiogram showed after seven years of 700+ cholesterol, why the EZPAVE trial headlines don't hold up under scrutiny, and what GLP-1s are doing inside the brain completely independent of weight loss. You'll also hear about the sardine diet experiment, the omega-3 thermogenesis connection, ketones as misfolded protein clearance agents, creatine for depression, retatrutide and PCSK9, BPC-157 risks, and what Nick believes is coming in Alzheimer's gene therapy within the next decade. Reduce your risk of Alzheimer's with my science-backed protocol for women 30+:https://go.neuroathletics.com.au/youtube-sales-page Subscribe to The Neuro Experience for evidence-based conversations at the intersection of brain science, longevity, and performance. _____ TOPICS DISCUSSED 00:00 Intro: The ApoE4 Paradox and the Case Report That Broke the Internet 00:57 Why Standard Omega-3 Supplements Fail and What to Take Instead 05:13 DHA and the Phospholipid Carrier: How It Crosses the Blood-Brain Barrier 10:19 ApoE4 Explained: Risk, Genetics, and Why Nick Is Optimistic 17:38 Why ApoE4 Carriers Burn Through DHA Faster and Need More 20:31 Women, Omega-3s, Menopause, and Brain Insulin Resistance 21:41 Statins, Sex Differences, and the DHA-Blood Sugar Connection 26:01 Statins and Dementia: What the Data Actually Say 32:24 Tau, GSK-3 Beta, Lithium Orotate, and Targeting Alzheimer's Pathology 42:19 The Glymphatic System, 40Hz Devices, and Sleep as Brain Clearance 45:21 Gene Editing, Prime Editing, and the Future of ApoE4 Therapy 49:33 Nick's Case Report: 700 LDL, Zero Plaque, and Seven Years of Data 55:10 The EZPAVE Trial: Why the Headlines Don't Hold Up 01:00:33 KetoneIQ: Ketones for Brain Energy and Focus 01:01:29 Cheers Health: Supporting Liver Function and Cognitive Recovery 01:03:54 If Not LDL, What Causes Heart Disease in Metabolically Healthy People? 01:12:05 The Oreo Experiment and the Sardine Diet: Self-Experiments in Metabolism 01:19:10 Ketones, Women's Brains, and Clearing Misfolded Proteins 01:21:08 The Full Brain Health Protocol: Omega-3s, Creatine, NAD, Lithium, and More 01:24:01 GLP-1s for the Brain: Independent of Weight, Targeting Amyloid and Tau 01:25:28 Peptides: BPC-157 Risks, Retatrutide, MOTS-c, and What's Worth Watching 01:29:02 Why Nick Is Controversial And Why He Doesn't Mind _______ Thank you to our sponsors Fenix Health Science: fenixhealthscience.com Use code NEUROEXP Pulsetto: https://pulsetto.tech/pages/NEURO or use Code NEURO for some off your order Function Health: https://www.functionhealth.com/louisanicola BASED Bodyworks: https://basedbodyworks.com/ and use code NEURO for 20% off KetoneIQ: https://ketone.com/NEURO for 30% OFF Cheers Health: https://CheersHealth.com/NEURO or use code NEURO for 20% off _______ I'm Louisa Nicola - clinical neurophysiologist - Alzheimer's prevention specialist - founder of Neuro Athletics. My mission is to translate cutting-edge neuroscience into actionable strategies for cognitive longevity, peak performance, and brain disease prevention. If you're committed to optimizing your brain- reducing Alzheimer's risk - and staying mentally sharp for life, you're in the right place. Stay sharp. Stay informed. Join thousands who subscribe to the Neuro Athletics Newsletter → https://bit.ly/3ewI5P0 Instagram: https://www.instagram.com/louisanicola_/ Twitter : https://twitter.com/louisanicola_ Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode of Rest, Eat, Move, we take a deeper look at omega-3 fatty acids and why the conversation about inflammation is often oversimplified. While omega-3s are essential for brain health, cellular function, heart health, hormone balance, and longevity, the bigger lesson is that health isn't just about isolated nutrients—it's about whole-food nutrition and how nutrients work together. We explore the history of omega-3 research, the importance of balancing omega-6 and omega-3 fats, and why cod liver oil remains a unique source of not only DHA and EPA, but also naturally occurring vitamins A and D, along with other beneficial fatty acids and inflammation-resolving compounds. The episode challenges listeners to think beyond supplement labels and focus on the quality, source, and biological context of the nutrients they consume.#Omega3s#InflammationHealth#CodLiverOil#FunctionalNutrition#WellnessPodcastontargetliving.com

Hosts: Ed Jones (Owner of Nutrition World) & Clint Powell A variety of topics all to living a healthy life Presented by: Nutrition World www.nutritionw.com Broadcasting from the Nooga Dentistry Studio www.noogadentistry.com Production of: Whitfield Media Group www.vitalhealthradio.com Title: All about Eggs & Pasture Raised Chickens with Kristy, Deprescribing & “De-Supplementing” with Dr. Curt Dearing [0:00:00] Intro, Nutrition World Updates, and Ed's Bodybuilding Prep Ed announces a new partnership with Azure: Bringing ~100 new holistic food items into Nutrition World. Examples: maple syrup, coconut oil, apple cider vinegar, organic chicken breast, cheeses, farm butters. Ed shares he's preparing for the Chattanooga Fitness Bodybuilding Contest (his 4th year): Being coached by Matt Davis (Train Station gym). Current approach: high protein, ~40% fewer calories, focused fat loss. Matt had him do a high-carb refeed day (~300g carbs vs his usual 50g) which dramatically improved his energy and look. [0:9:11] Protein, Longevity, and Why Ed Focuses on Eggs Ed emphasizes a higher-protein diet, especially for aging, muscle maintenance, and longevity. Core diet elements he advocates: Higher protein Healthy fats Colorful vegetables (in smaller but consistent amounts) Notes many women under-consume protein, which accelerates muscle loss and impacts longevity. Introduces guest Kristy, a long-time friend and staff member who homesteads and raises eggs that Ed eats 12–18 per week. [0:11:04] Homesteading with Kristy: How She Raises Chickens and Protects the Flock Kristy's setup: Around 100 chickens, plus goats, dogs, cats, and a donkey (Bradford). Lives “on the prairie” (rural, wooded property). Uses no chemicals on the property (no weed killers, pest sprays, etc.). She wants chickens to “do chicken things”—roam, peck, eat bugs, move soil—rather than be treated like pets or indoor animals. Predator control: No perimeter fence; previously lost some chickens to a fox attack. Now uses Bradford the donkey and a Great Pyrenees dog for protection: Donkey alerts and deters daytime predators like hawks and owls (stomping and loud calls). Pyrenees patrols at night, primarily deterring coyotes. Roosters herd hens into cover when threats appear. Motivator: Kristy's passion for knowing where her food comes from, and controlling at least part of her family's food system. [0:15:09] Structured Water, and Animal Hydration Kristy filters all animal water with a high-grade system (not just a basic fridge filter): Removes contaminants without completely stripping all minerals (not full RO). Then she “restructures” the water with a swirling device (structure unit): Mimics water flowing over rocks in nature, believed to add “life” and energy back to the water. She and Ed both report feeling better hydration from structured water (less persistent thirst). All of her animals receive this filtered/structured water. [0:17:26] Egg Production, Breeds, and Why Yolk Color Matters Kristy keeps multiple chicken breeds: Shell color = breed, not nutrition (white, brown, cream, etc., are just different breeds). Example: White Leghorn → white eggs, Rhode Island Red → darker brown eggs. Key nutritional indicator: yolk color She aims for deep orange yolks. Pale yellow yolks signal lower nutrient density, especially protein and nutrient intake from the chickens' diet. Production basics: Most hens lay about 5–6 eggs per week, especially in their first 3 years. Ed and Clint estimate she's getting hundreds of eggs per week in total. Kristy's flock policy: She has a “no-kill” policy for older hens, keeping them for tick and bug control and the social flock structure. Acknowledges some people cull flocks after 2–3 years, but she tends to keep productive, healthy hens past 4 years. [0:19:37] Industrial Eggs vs. Pasture-Raised: Animal Welfare and Nutrition Ed contrasts Kristy's setup with CAFO operations (Concentrated Animal Feeding Operations): Chickens crowded in small cages, poor conditions, bad feed. Notes such operations often use antibiotics—partly for disease, but also because they fatten animals. Kristy's holistic management: No antibiotics; uses natural anti-parasite and immune support: Pumpkin seeds for worms Homegrown herbs like oregano and rosemary She builds a strong “terrain” (internal environment) in the animals so they resist disease better. Discussion that what chickens eat (seed oils, moldy grains, etc. in industrial systems) ultimately affects the nutritional quality of the eggs humans eat. Nutritional highlights of eggs: Choline in yolks (brain and cognitive health). A “perfect protein” with high biological value and broad micronutrients. Eggs historically rank at the top for turning dietary protein into muscle due to a complete amino acid profile. Cholesterol discussion: Ed challenges the blanket fear of cholesterol: Cholesterol supports hormone production and brain function. Notes that the real risk markers are advanced lipoproteins like ApoB and Lp(a), not total cholesterol alone. Personal example: Ed eats 12–18 eggs per week. & his cholesterol is extremely low by clinical standards. Conclusion: Quality eggs are encouraged, especially from pasture-based systems like Kristy's, or higher-quality options in stores. [0:23:15] “Organic” vs. “Pasture-Raised” and Misleading Egg Labels “Organic eggs”: fed organic feed but may still be confined indoors with no outdoor access. “Pasture-raised”: hens are outdoors on pasture, doing natural chicken behaviors; often superior in welfare and nutrition. Both agree: If forced to choose, pasture-raised is preferable to organic-only. They call out labels bragging about “vegetarian-fed” hens as misleading: Chickens are not natural vegetarians; they're omnivores that eat bugs. Forcing a vegetarian diet moves them away from their natural food and may reduce egg quality. Kristy shares a quirky but natural behavior: Chickens love scrambled eggs as a treat. She feeds them scrambled eggs and crushed shells. Rationale: Eggshells are rich in calcium, which hens need to build strong new shells. She simply cracks and throws shells; no elaborate processing.. [0:27:25] Refrigeration vs. Room-Temperature Egg Storage Kristy's explanation: Freshly laid eggs have a “bloom” or natural protective coating that makes them shelf-stable if not washed. Unwashed farm eggs can sit at room temperature for ~6 weeks or more. Store-bought eggs are washed and must be refrigerated, because washing removes that protective coating. You cannot safely leave standard grocery-store eggs on the counter. Ed highlights this as another example of nature's built-in protective design. [0:32:28] Deprescribing and “De-Supplementing” with Dr. Curt Dearing Ed reintroduces Dr. Curt Dearing to expand on a prior show about deprescribing (reducing excessive medications). Common scenario Curt sees: People on many prescription meds plus a large number of supplements, overwhelmed and confused. They want to simplify, optimize, and know what really matters. Curt's consult approach: Review all meds and all supplements, then: Remove what isn't necessary. Emphasize foundational lifestyle and core supplements. They warn about a false sense of security: Some people think “I'm taking a pill, so I don't have to change my habits.” This applies to both pharmaceuticals and nutraceuticals. [0:36:00] The Core Four, Lifestyle First, and Limits of Medication-Only Approaches Ed references his “Core Four” foundational supplements (detailed in a free ebook on The Holistic Navigator): Designed as tier 1 essentials vs. lower-tier “nice-to-have” supplements. Curt's stance: Diet and exercise are the primary pillars. Supplements should support, not replace, healthy habits. Example: People on metformin or berberine may keep eating poorly yet feel “covered” because their blood sugar numbers look better. This is managing symptoms, not addressing root causes. [37:15] “Beyond Cholesterol” and Advanced Heart Risk Testing Curt mentions his upcoming ebook “Beyond Cholesterol” (targeting Amazon release): Argues standard lipid panels (total cholesterol, LDL, HDL) are not enough. Advocates for advanced tests like ApoB, Lp(a), and coronary calcium scores. Example case: A patient with LDL of 212 on atorvastatin. Curt notes that LDL alone can be “dangerous or harmless” depending on the underlying particle types and inflammation. Coronary Calcium Score: Patient's score is 0, which is reassuring but not a free pass. Calcium score detects calcified plaque, not soft plaque, and doesn't capture inflammation. Curt emphasizes HS-CRP (high-sensitivity C-reactive protein) as a marker of systemic inflammation, which drives soft plaque formation. [0:40:22] Medications in the Case Study: Statin, Nexium, Amlodipine, Zoloft Curt walks through a specific patient on multiple meds: Atorvastatin (statin) Curt questions its necessity given: Calcium score of 0 Lipid values that don't look catastrophic Recommends advanced lipid testing and provides patients with evidence-based reasons to discuss with their provider if they want to stop. Nexium (PPI) Discusses risks of long-term proton pump inhibitor use: Impaired absorption of magnesium, calcium, micronutrients Possible cognitive, kidney, and bone issues. Insists on a taper, not cold turkey, due to rebound reflux. Amlodipine (blood pressure med) Often can be tapered fairly quickly, especially when: Lifestyle changes are implemented (diet, exercise). Magnesium intake is optimized (many people take too little magnesium). Curt's view: conventional medicine often drives blood pressure too low in older adults; some elevation is physiologically adaptive. Zoloft (SSRI) Must be tapered, like most psychiatric meds, to avoid withdrawal and symptom flare. [0:46:10] Magnesium, Omega-3s, and Simplifying the Supplement Stack Curt reviews the patient's supplement list and simplifies: Multivitamin: Advocates a high-quality multi (not basic synthetics like Centrum). Prefers one that already includes CoQ10 (e.g., 100 mg), so separate CoQ10 can be discontinued. Vitamin D: Should be taken with vitamin K to direct calcium into bone and away from arteries and organs. Omega-3s: Many people take half the necessary dose. Recommends triglyceride-form omega-3s like DHA Extra (~960 mg DHA) for inflammation and blood pressure. Magnesium: Suggests glycinate or taurate forms for better absorption and blood pressure benefits. Probiotics: Curt suggests taking breaks (e.g., a month off) and rotating brands/strains, including spore-based types. Seasonal products: The patient takes quercetin + stinging nettle for allergies. Curt recommends seasonal use only for seasonal allergies, saving money and reducing pill fatigue. For lipids and blood sugar, Curt favors BerberCol (berberine + bergamot) to: Improve numbers (to satisfy doctors). More meaningfully affect ApoB and related risk markers. Weight & energy: Patient had been using weight-loss products. Curt shifts focus to fixing sleep and overall lifestyle rather than stacking more “fat burners.” Saffron: He distinguishes between saffron extracts for mood vs. saffron for weight management—formulation details matter. [0:54:57] Closing: Funding for Alternative Health and Supplement Tax Benefits Ed shares policy/legislative updates: Alternative health funding preserved in the federal budget. Initial fear that support would be cut; instead, it was kept in the proposed budget. The Dietary Supplement Access Act proposal: Would classify dietary supplements as a qualified medical expense in the IRS code. Allow individuals to claim up to $500/year (and $250 for married filing separately) for supplements. Could apply to common products like multivitamins, vitamin D, etc. if/when finalized.  The post Radio Show / Podcast – June 14, 2026 first appeared on Vital Health Radio.

Discover why hormones are off and what's really driving the imbalance. In this episode, we break down five root causes — from gut dysfunction and disrupted sleep to chronic stress, appetite dysregulation, and omega-3 deficiency — and walk through what you can actually do to fix it. FEATURED PRODUCT Berberine is a powerful botanical compound that acts as a natural GLP-1 supporter — the same metabolic pathway targeted by medications like Ozempic — helping regulate blood sugar, reduce insulin resistance, and restore appetite signaling from the gut. Since metabolic hormones like insulin and leptin are the first to derail your entire hormone cascade, Berberine directly addresses one of the deepest root causes discussed in this episode. It also supports gut microbiome diversity, making it a foundational tool for anyone working to reclaim hormonal balance naturally.

This is a practical conversation on circadian living — how to structure your day around light, darkness, food, movement and sleep in a way that supports your biology. We also explore the modern mismatch of indoor LED lighting, artificial light at night, late eating, phone use before bed, blue blockers, beeswax candles, incandescent light, night driving, flicker, skin cancer nuance, sun exposure, DHA, omega-3s and the deeper philosophical implications of living in rhythm with nature. CONSULT DR MAX

A new Alzheimer's study linked omega-3 fish oil (EPA & DHA) supplement use to faster cognitive decline, but the real story is far more nuanced than the headlines suggest.In this discussion, cardiologist Dr. Bret Scher breaks down the study and explains why the quality, freshness, and source of omega-3s may matter more than most people realize.The study used data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) and found that omega-3 supplement users experienced greater cognitive decline over five years compared to non-users. But the details matter:The study did not assess supplement quality, oxidation, dosage, or dietary habitsOxidized fish oil may behave very differently from high-quality DHA and EPAWhole food omega-3 sources like salmon, sardines, and mackerel consistently show different outcomes in researchLifestyle factors like sleep, exercise, stress, and metabolic health remain critical for brain healthOne of the biggest takeaways: supplements are not interchangeable with whole foods. And no supplement can replace the foundation of metabolic health, including nutrition, movement, sleep, stress management, and social connection.

Dr. Deb Muth 00:00:09 Hi there, how are you? Bob Miller 00:00:10 Excellent! Pedaling as fast as humanly possible, but doing okay. Dr. Deb Muth 00:00:14 Good, good. Well, I’m looking forward to our conversation today. This should be amazing. Bob Miller 00:00:20 Yeah, it should be a lot of fun. Dr. Deb Muth 00:00:22 Yeah, anything that’s off-limits for you in, our conversation? Bob Miller 00:00:28 No. Dr. Deb Muth 00:00:29 Okay, anything you want me to make sure we cover for you? Bob Miller 00:00:33 Well, I mean, is it okay if we put a little plug-in for our software? Dr. Deb Muth 00:00:35 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:38 Hey, can we… can we do a screen share? Yes, we can. Yeah, because I want to show you some maps, and… Dr. Deb Muth 00:00:43 Okay. Things like that, yeah, so… Perfect. So just let me know when you want to do screen share. Bob Miller 00:00:48 Okay. Dr. Deb Muth 00:00:49 And yeah, feel free to plug your software wherever you want to. Bob Miller 00:00:53 Okay, well, good. Let me pull up a, a slide for that, and give me one second, I just want to shut the door to my office to get the noise down. Dr. Deb Muth 00:01:01 No worries. Bob Miller 00:01:16 And, how should I refer to you? Dr. Debb? Dr. Muth, what do you like? Dr. Deb Muth 00:01:18 Dr. Deb is great, or Deb, either way, I’m pretty informal, so… Bob Miller 00:01:22 Yeah, and… Bob is fine for me. Okay. Yeah. Yeah, there you go. Why people feel like they need this, son. Special name, it’s like, seriously. Dr. Deb Muth 00:01:33 Right? I agree. Bob Miller 00:01:35 When I work with my clients, it’s like, Dr. Millison, just, just bop, just, just bop. Dr. Deb Muth 00:01:41 Yep, that’s how I am, too. Just call me Deb, it’s good. Dr. Deb Muth 00:01:44 They feel a little awkward with that, you know? They’re not used to that, but… Bob Miller 00:01:48 Alright. And you’re a naturopath, medical doctor. Dr. Deb Muth 00:01:52 A nastropathic doctor and a nurse practitioner. Oh, nice. Yeah, so I got the best of both worlds, right? Bob Miller 00:01:58 Yeah, damn. Okay. Alright, so here we go… There we go. Alright, so I got that ready, and then I will do a, I will do a screen share. I think you’re gonna really, appreciate what we’ve come up with. We’ve come up with the concept of, Cellular CPR. Dr. Deb Muth 00:02:23 Oh, nice! Bob Miller 00:02:24 And that is, construct the cell membrane, Protect the cell membrane. And restore it if it’s damaged. Dr. Deb Muth 00:02:32 Love that. Bob Miller 00:02:34 I love that. Yeah, so that’s what we’re focusing on, and then how, You know, we want to get to the point that, you know, most people think of genetics, they think of, like, 23andMe or Ancestry. Dr. Deb Muth 00:02:44 Yeah. Bob Miller 00:02:45 And then you have the professional geneticists who are looking at, you know, odd things that could create a disease. We’re looking at functional genomics. Dr. Deb Muth 00:02:54 Which is so much better. Bob Miller 00:02:56 Yeah. Are you familiar with what we do here, or… Dr. Deb Muth 00:02:58 A little bit, a little bit. So, it’ll be new to me, too, so I’m excited. Bob Miller 00:03:03 And how much time do we have? Dr. Deb Muth 00:03:04 We have an hour, give or take a little bit on either side. Do you have a hard stop anywhere? Bob Miller 00:03:10 No, no, I put a, I moved my clients around, and I don’t have anybody till, 3.30, so we’re good. Okay. Dr. Deb Muth 00:03:16 Perfect. Alright. Bob Miller 00:03:18 It’s like we’re getting started early as well, so… Dr. Deb Muth 00:03:19 Yeah, we’re getting started a little bit early, so that’s good. Bob Miller 00:03:22 Yeah, I just got my office cleaned up, so… Dr. Deb Muth 00:03:23 Okay, good. All right, are you all set to get started? Bob Miller 00:03:28 I’m good to go, my friend. Dr. Deb Muth 00:03:29 I’m gonna just record a little intro and a little bit of a, hook for people, and then we’ll get started. I’ll ask you to kind of tell us a little bit about yourself, and then we’ll just take this conversation wherever it’s supposed to go. Bob Miller 00:03:39 Okay, you got it. Dr. Deb Muth 00:03:40 Alright, sounds good. So what if the reason you’re not healing isn’t your diet, your supplements, or your labs, but it’s actually your genes? Dr. Bob Miller is uncovering how genetic variants, when combined with modern toxins, explain why some of us stay sick no matter what we try. Today, we’re talking genetic pathways, detox blocks, and the new science every wellness warrior needs to know. Welcome back to Let’s Talk Wellness Now, the show where we uncover the root causes of chronic illness, exploring cutting-edge regenerative medicine, and empower you to heal from the inside out. I’m Dr. Deb, your medical detective, and today, our guest, Dr. Bob Miller, is a true pioneer in functional genomics. He’s a board-certified traditional naturopath and the founder of Neutrogenetic Research Institute. And he’s the leading groundbreaking research on how genetic variants influence chronic illness, inflammation, and detoxification. His work has been recognized on international stages, uncovering links between genetic expression and conditions like Lyme disease, mast cell activation, or MCAS, and mitochondrial dysfunction. I’m so excited to talk to Dr. Bob today. He is gonna reveal some things that even I don’t know about, so I’m excited to learn alongside of you guys. So… Dr. Bob, let’s get started. Tell us a little bit about yourself, and kind of how you got on this journey. Bob Miller 00:05:04 Well, that’s, that’s interesting. I was sort of like a mid-career coming to the natural health field, because in my early 30s, I found myself with a severe case of ulcerative colitis. Bob Miller 00:05:15 And I was in the hospital for 21 days. probably within hours of death, pleading to death. And they told me I’ve got one option, and that is cut out the colon and wear a bag. Didn’t sound like a lot of fun. Dr. Deb Muth 00:05:27 Not an option I would want. Bob Miller 00:05:29 So, you know, the medical folks wasn’t real happy with me, but I said, yeah, I’d like to explore some alternative things.Never thinking that I’d get into this field, and then I just, you know, worked with some herbalists and things that I found absolutely fascinating. So, that’s how I got into this around 30 years ago. And, haven’t looked back since, and just having a… having a blast as we now move into how our genetics impacts things. So, that’s what we’re gonna… that’s what we’re gonna talk about today. Dr. Deb Muth 00:05:58 I’m excited to talk about this genetic thing. When you started over 30 years ago, what kind of patience and problems first inspired you to dig deeper into that root cause healing and kind of get into the genetic piece of it? Bob Miller 00:06:10 Sure. Well, you know, as a… now, I’m in a part of the country called Lancaster County, Pennsylvania, where there’s a lot of Amish and Mennonite, and they gravitate towards these things.So, this is their first thing to do, and that doesn’t work, then they’ll go other routes. So, you know, back then, we just saw typical, you know, a little tired, constipation. You know, a little bit of fatigue, arthritis, those kind of things. But things have changed dramatically over the years, as people are now getting more chronically sick. You know, it’s worse than it’s ever been. And what we’re finding is the, the culprits Primarily is mold exposure and Lyme disease. When people get those two together, they’re just… it’s an inflammatory cascade that nobody can seem to unravel. So that’s where we spend a lot of our time. And we’re also spending a lot of time looking at mental health, like ADD, ADHD. And, we give… this year I’ll be speaking at three autism conferences. And we can dig into that a little bit as to why we think we’re seeing such a dramatic increase. And aside from autism, that used to be 1 out of 1,000, now it’s 1 out of 33, or 23. You know, we’re also seeing dramatic increases in ADD, ADHD. People are stressed out. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. Dr. Deb Muth 00:07:37 This should be a fun visit. We can cover lots of topics. I am so excited. So, you founded Nutri Genetic Research Institute in 2015. What did you hope to accomplish, and what kind of surprised you in your findings so far about that? Bob Miller 00:07:51 Well, you know, let’s back up at what, you know, genetics is used for. Everybody’s familiar with 23andMe and Ancestry that, you know, tells you where your ancestors came from. Then you have your professional geneticists. I mean, these are people with a degree in genetics. And they’ll look for, you know, very odd sort of things that are prone to relate to a disease. So there are disease-related genetics. Well, in functional, we don’t look at either of those. We look at For example, how you’re breaking down your fats and utilizing them. How you’re recycling your glutathione. How you might be handling your iron. And none of those are disease-causing on their own.And none of those are disease-causing on their own. But when they pile up on you, and then combine that with environmental factors, that’s when things start to go south on us. So, that’s what we’re doing, we’re looking at patterns. And our first foray into this was, we did studies on Lyme disease. And our first foray into this was, we did studies on Lyme disease. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. Others have a little more struggle, and then others are struggling terribly for years. So there’s an old adage of genetics loads the gun, environment pulls the trigger. Dr. Deb Muth 00:09:14 Yeah, that is so true, and I think when we’re talking about Lyme and mold and things like that, we forget sometimes that our genetics can predispose us to be more sensitive to those things, and if we have genetic pathways where we don’t clear things properly, it’s harder for us to get them out of the body. And then you add on that whole rain barrel effect that we’ve always used as a functional medicine term, right? If the barrel’s half full, you’re okay. If it’s full, and now it’s spilling over, it’s a bigger problem. Have you guys found, too, that some of these environmental things actually are changing the genetics of people, or how they’re processing their own genetics? Bob Miller 00:09:53 Well, let’s go back to, Genetics 101. But we’ll go back a little bit further. So, what an interesting mechanism, what a miracle the body is. Bob Miller 00:10:03 Fats, carbohydrates, proteins, drink water, breathe air, expose the sunlight, and somehow everything gets made. I mean, when you just step back and think about that, it’s like, It’s pretty darn amazing. Dr. Deb Muth 00:10:15 I always tell women, you know, the fact that we get pregnant and we have healthy pregnancies and births is a miracle, because if we had to try to control that, that wouldn’t work so well. Bob Miller 00:10:25 Right. Well, that’s another miracle. These microscopic sperm and egg, human being, 9 months later, it’s like. But even inside of us. We are making our hair, our skin, our nails, our blood vessels, our ATP, our energy, it’s all being created. Well, that gets created by enzymes. So, enzymes take one substance, combine it with something else, and make something new. Then another enzyme comes along and does the same thing. Your DNA is the instructions on how to make the enzymes. So, when we are conceived. If it’s a, if it’s a female, of course, it’s the XX, the two chromosomes. You know, we’ve… everybody’s seen those… the genetics that… Listed pair. So, if it’s a female, the father donated the X enzyme. And the mother has no choice but to give the eggs, so that’s female. If the father donates the Y, you have a male that’s in chromosome number 1. Then 2 through 23 is the rest of the instructions on how to make enzymes. So, what can happen? We can get what are called SNPs, single nucleotide polymorphisms. And SNPs just mean that the instructions to make the enzyme’s not quite as good. So, if one parent gives a SNP on the making of an enzyme, The enzyme’s fine. It works. But, general rule of thumb, It may only work at 70-80% of efficiency. Now, a good analogy is think of an 8-cylinder and a 6-cylinder car. If parents give you good information, that’s like having an 8-cylinder car. If one parent gives you that snip, it’s like having a 6-cylinder car. Now, is a 6-cylinder car a fine car? Sure. It’ll get you from point A to point B, but it’s just going to have the power of an 8-cylinder. Then if both parents give you a SNP on the same enzyme, it may be 30-40%, and that’s like having a 4-cylinder car. Sits in the driveway, looks the same, puts gas in it, everything. But if you’ve got a 4-cylinder car. Probably not a good idea to go cross-country pulling a trailer behind you up and down mountains. Dr. Deb Muth 00:12:29 This is true. Bob Miller 00:12:32 So… We can get an 8-cylinder, 6-cylinder, or 4-cylinder enzyme. Now, if it’s not under a lot of stress, if that 4-cylinder car is just taking you to the bank and the grocery store. It’s just as good as an 8-cylinder car. But if you gotta pull that trailer, and there’s a lot of stress on it, being mountains, it’s gonna struggle. Now, there’s one other little caveat to this, and that is some genetic mutations are gain-of-function. They actually work faster. Now, we have enzymes that do all kinds of things. We have enzymes that make and recycle our antioxidants, but we also have enzymes that make inflammation. No, that’s a good thing, because if we get a virus or bacteria, if you didn’t make inflammation to kill it, well, we’d all die of infection. So, you know, we tend to think of free radicals as bad, antioxidants as good. They both play an important role. But interestingly, some of the major enzymes that make inflammation, they can be overactive. They can be turbocharged. And when they’re stimulated by environmental toxins, they overreact. Bob Miller 00:13:40 And therein lies the problem. When they overreact, we have a problem. Bob Miller 00:13:46 So, if we have genes that overreact when stimulated. And then the enzymes that take care of inflammation are underactive. Then you’re gonna be more inflamed. You know, the majority of people that, you know, come for functional medicine Or naturopathic help, or… Inflammation that they can’t seem to get under control. Dr. Deb Muth 00:14:06 Right. Bob Miller 00:14:07 And we will be, you know, during this hour, we’re going to look at some of the pathways that make that happen. So, what we can do then, we can’t change our genetics. When you’re conceived, that’s the hand you’re dealt. When your life would be over, if someone would take some tissue and measure, it’d be exactly the same as conception. Does it change. Bob Miller 00:14:28 The enzyme’s ability to do its job may be compromised. Because remember I said there’s a, the enzyme takes a cofactor. So an enzyme takes substance A, cofactor, make substance B. Well, if that cofactor’s not there, the enzyme’s not going to work either. So, you could have an 8-cylinder car, and if there’s no gas in it, it’s not going anywhere. So… It’s the strength of the enzyme, it’s the cofactor to do the A to B conversion. And that’s what we’re going to get into. So, many people say, well, where did these SNPs come from? Nobody knows for sure. Sometimes they’re what’s just called de novo, when the sperm and egg go together, the instructions get mixed up a little bit. We do believe a lot of it came from a long time ago, when we were almost wiped out by sexually transmitted diseases. And those STDs were altering the genes when the conception, in other words, when the sperm went into the egg, the STDs were interfering. And causing the problem, so… I often joke, if you want to blame somebody. Blame your great-great-great-great-great-great-great-grandparents for, being a bit promiscuous, so… Dr. Deb Muth 00:15:31 Yeah, for being… having a little too much fun, right? Bob Miller 00:15:35 So, we don’t know for sure, but, you know, there are some that, But most of the SNPs that we get inherit from our parents. So, if you look at a child. And you look at the SNPs. 99.9% of the time, it came from one of the parents. Dr. Deb Muth 00:15:50 In identical twins, do they have the exact same identical makeup? Bob Miller 00:15:54 Yep, Dr. Deb Muth 00:15:56 But not in fraternal twins, correct? Bob Miller 00:15:59 No, no, those could be different, Jeff. Dr. Deb Muth 00:16:00 It could be different because they have different sacs, they’re not sharing that same genetic makeup. Bob Miller 00:16:04 Yeah, so keep in mind, both your mother and your father have, you know, the two And so you get one from one parent, one from another. Dr. Deb Muth 00:16:13 So… Bob Miller 00:16:14 Interesting situation. I had, 3, 3 boys. And, we were looking at an enzyme related to breaking down oxalates. Now, the mother and father each had one SNP, and that’s called heterozygous. Three boys, and they all come together, they’re Amish boys, they’re a lot of fun. And I looked at their genomes, and the one boy didn’t have any SNPs at all. And one had won. And the other one had two. Dr. Deb Muth 00:16:41 Interesting. Bob Miller 00:16:42 So, we don’t quite know how these things get handed off, but with the parents each having one, you could have a child with none, one, or two. So, the one, his ability to break down oxalates, which is fine. The other one was slightly impaired, and the other one was dramatically impaired. So, you can have 3 children, and it all depends what the parents have. Now, if a parent has a homozygous, or 2 copies. And the other parent has nothing. Every child will have one. Okay. If both parents are homozygous, that they both have two, Every child will have two. Dr. Deb Muth 00:17:19 too. Bob Miller 00:17:20 Yes, so that’s the way it works, but, you know, but it’s somewhat rare that both parents are homozygous on an enzyme, but it can happen. Dr. Deb Muth 00:17:27 Do we think that infections today, like Lyme disease or mold exposure, things like that, if the parent, the woman, primarily, I’m thinking, is pregnant, and she actively has these infections. Can those infections affect the genetics, kind of like a past sexual transmission did where we thought back in the day? Bob Miller 00:17:47 Yeah, I… I mean, I’m not that much of a geneticist to answer that for sure, but my thought would be no, that at conception, the pattern’s made. Dr. Deb Muth 00:17:55 Okay. And then that’s… that’s the hand you’re dealt. Bob Miller 00:17:58 Yeah. So, I tell people we have good news and bad news. The good news is we can compensate for the weakness. The bad news is we can compensate for the weakness. Dr. Deb Muth 00:18:09 That is so very true. Bob Miller 00:18:11 Yeah, we can’t, because I often get asked, so we’ll do some things now, and we’ll check my genes again, and they’ll be better. It’s like, nope. Dr. Deb Muth 00:18:18 Oh, – – Bob Miller 00:18:19 You gotta play the hands you’re dealt, so… Dr. Deb Muth 00:18:21 That’s right. Bob Miller 00:18:22 You can test your genetics… if you’re looking at the same enzyme, you can test it every year. It’s not gonna change. It’s like the blueprint. Dr. Deb Muth 00:18:30 It’s good and bad, right? It’s the one test you only have to do once in your lifetime. Bob Miller 00:18:34 No, unless, you know, like, our. Dr. Deb Muth 00:18:36 All the time. Bob Miller 00:18:37 Yeah, now our test looks at, called the Functional Genomic Analysis Test of your genomic Resource. We look at 220,000 steps. Dr. Deb Muth 00:18:46 Wow, that’s a lot. Bob Miller 00:18:47 That’s not all of them. Dr. Deb Muth 00:18:49 Right. Bob Miller 00:18:50 So, maybe in the next year, we’re gonna come out with our third version of the chip. And then, if someone wants to get those new things that weren’t on it, they’d have to repeat. But whatever we measured is gonna stay the same. Dr. Deb Muth 00:19:03 That’s a lot of SNPs to look at. Bob Miller 00:19:05 Keeps us busy. Dr. Deb Muth 00:19:06 But there’s still, but there’s still SNPs that we. Bob Miller 00:19:09 That we’d like to have that we don’t have, so… Bob Miller 00:19:11 We started out with version 1 on our genetic test, then we worked with version 2, and we’re already compiling a list of what version 3 would look like. So if somebody has our version 2, And we’re saying, you know what, it’d be nice if we could see these, well, then you’d repeat, but it won’t change what you already know, so… Dr. Deb Muth 00:19:29 Got it, got it. So, when you started out, and you started looking at the research of Lyme disease and chronic infections, which detox pathways are most important for people who struggle with those conditions? Bob Miller 00:19:43 Okay. You know what might make sense as we do a screen share, and I’ll actually show you the pathway. Does that make sense? Bob Miller 00:19:48 Alright, so… let’s see if I… let me just press the share… Dr. Deb Muth 00:19:52 Yep, you should just be able to press share. Bob Miller 00:19:54 And… number 2. Okay. Are we seeing the screen there? Bob Miller 00:20:01 Okay. Dr. Deb Muth 00:20:02 So, this is a map that we made. Bob Miller 00:20:05 And by the way, this is not… All-inclusive of all the things we look at, but we believe this is a core issue. So, where we’re going to start here, there’s something called the microglia. And the microglia are glial cells. They’re in the brain and the central nervous system. And they’re very interesting little creatures, because most of the time, and this is just a drawing of what they sort of look like. Most of the time, they’re in what’s called the M2 anti-inflammatory mood. What that means, these little guys pick up dirt, debris, Recycle them. Turns on an enzyme called interleukin-10 that’s anti-inflammatory. And just kind of does general housekeeping. And just kind of does general housekeeping. However, when a trigger comes along. However, when a trigger comes along. They… it’s the same glial cell, but it moves over to a very pro-inflammatory enzyme. A pro-inflammatory glial cell. And it triggers these 3 enzymes, Actually, these four. That are pro-inflammatory. Tumor necrosis vector alpha, Interleukin-6. NF Kappa B, Inos. Now, these create inflammation. So you might think, well, why is that good? Well, if you have some foreign invader, virus, bacteria coming in, parasite. If you didn’t have these guys coming to the rescue, you would just die of infection. So, these guys are your friend unless they’re your worst enemy. Because TNFA, and we’ll show you when we actually do a demo account, TNFA can be overactive. So, in other words, it over-responds. Interleukin-6 can be overactive. And if Kappa-B can be overactive. The INOS, and I’ll explain each of these as we go through a demo, can be overactive. Now, what that means is, you’re very good at killing virus and bacteria. But this is where autoimmune disease comes in, and just inflammatory conditions. Now, this is just speculation, but we think what happened is, as you know. Thousands of years ago, we didn’t have refrigeration, we didn’t have sewer, we didn’t have pure water, and we didn’t have antibiotics. So, if you made it to 40, you were an old-timer, because everybody was dying of infection. So, what we believe happened is, by what’s called natural selection, Having these overactive. A thousand years ago was to your advantage. Dr. Deb Muth 00:22:31 Hmm. Bob Miller 00:22:32 But now… We have pure water, we have refrigeration, we have sewers, we have antibiotics. But now we have environmental factors that are stimulating them. Now it’s to our disadvantage. And we’ll talk about that a little bit as it relates to the hemochromatosis genes and maybe the G6PD. Dr. Deb Muth 00:22:48 Yep. Bob Miller 00:22:49 Now, why are we becoming so inflamed? Let’s look at the triggers. Now, one of my, favorite expressions is. I was born all the way back in 1954. Dr. Deb Muth 00:23:01 And it was a different world back then. Bob Miller 00:23:05 These are some of the triggers. And we’ll get into these, but right now, high fructose corn syrup, And the high-fat diet. High fructose corn syrup only came about in 1968. So now we’re being exposed to high fructose corn syrup. Then… we didn’t have these, these viruses like COVID. Dr. Deb Muth 00:23:26 Yeah. Bob Miller 00:23:27 Now, there’s now pretty strong evidence that COVID Was actually, you know, made as a gain of function. It’s debated, and I’m not taking an opinion on it, but there’s some people who believe Lyme disease was also a part of experimentation. Dr. Deb Muth 00:23:40 Go. Bob Miller 00:23:41 Then we have molds, and it appears as though mold is getting stronger. you know, 20 years ago, when I was seeing folks, mold wasn’t on the radar. I would say 7 out of the 10 folks we speak to today have mold problems. Yeah, 20 years ago, we talked more about mold allergy being an issue versus mold toxicity being an issue. Right. So… I know some folks are, you know, speculating what’s happening, but one of the theories out there is that EMF is strengthening mold. I don’t know if you ever heard that theory, and I don’t… Dr. Deb Muth 00:24:13 I have. Bob Miller 00:24:14 I’m not claiming it’s true, but it’s an interesting theory. Then even, you know, your black mold from water-damaged buildings. Then our air pollution is getting worse. We’re getting more toxic metals. Dr. Deb Muth 00:24:26 You know, if we have a… Bob Miller 00:24:27 You know, we’re gonna look back someday and say, what were we thinking, smearing aluminum into our armpits? The, what were we doing putting mercury in our teeth? Then, you know, glyphosate. When I was a kid, there was no glyphosate. So, all of these herbicides and pesticides. Polychlorinated biphenols, And then EMF. So, we love our cell phones, you know, and I think unless you, or in the middle of the desert, or down in a cave, you’re being exposed to EMF somewhere. So, you know, we have our cell phones with us, we have, We have Wi-Fi, the towers are everywhere. And we don’t know long-term, but we may find that this can… this creates some inflammation. And I don’t know if you get any folks, but do you have any folks that have… are they EMF sensitive? Dr. Deb Muth 00:25:16 Oh yeah, we have a whole bunch of them. Bob Miller 00:25:18 Yeah, and then if you have any TBIs, So, plenty of things here. that will stimulate into the microglia, M1. Now, you could say, well. We’re all pretty much exposed to the same thing. Why do some people get hit harder than others? So here’s where we’re gonna start. There’s an enzyme called Nrf2 and RF2. And Nrf2 is the enzyme that senses when there’s inflammation. And turns on hundreds of anti-inflammatory enzymes. We’ll show when we do the demo, you can have genetic weakness on NERF2. And NERF2 inhibits and slows down microglia M1. supports M2. Now, if it’s not complicated enough, there’s an enzyme called KEEP1. And KEEP1 inhibits NRF2. And you can actually have gain of function on keep 1, that makes Keap 1 stronger. So… A lot of the people who land on my doorstep So… A lot of the people who land on my doorstep Both parents gave a mutation on KEEP1, making it overactive. Both parents gave a mutation on KEEP1, making it overactive. Dr. Deb Muth 00:26:31 Hmm. Dr. Deb Muth 00:26:31 Hmm. Bob Miller 00:26:32 Suppressing Nrf2, nerve 2 might be weak. So, nobody’s putting the brakes on, M1. And by the same token, Nerve 2 supports M2. Then there’s a process called mTOR and autophagy. mTOR stands for mammalian tard of rapamycin, the growth of new cells. And then autophagy, taking our dead cells and recycling them. We need a balance between the two of them. If we didn’t have mTOR, the sperm and the egg would never become the baby, the baby would never become the adult, we wouldn’t make new cells. But our cells are constantly, you know, the old cells dying off. Autophagy is where we take that debris from the cell and recycle it, just like a farmer Plows the crop under at the end of the year. The dead plant then becomes the fuel for the spring, your dead cell becomes the fuel for the spring, and that’s autophagy. So we’re gonna look back someday and say, what were we thinking? We give our animals growth hormones so they get fatter faster. Oh my. So, we consume those animals, and inventory runs faster. Now, for anybody who’s, You know, maybe above 40, 45 years old. Think back when you were 12, and what did girls look like? They were primarily flat-chested little girls. Now they look like 16-year-olds. Because environmentally, we’re jacking up mTOR. So, mTOR stimulates microglia M1, suppresses microglia M2. Probably 80% of the folks we visit with. This is the part of the problem. NRF2 is weak. mTOR is strong. Environmental factors come along. And this guy gets carried away. He doesn’t do that burst and move back. Stays here. We’re calling that How environmental factors create a locked-in, pro-inflammatory. and neurotoxic phenotype. In other words, once it starts, it just keeps… Feeding upon itself. Alright, so what happens now when microglia is overactive. it triggers these 3 enzymes, TNFA, N of kappa B, And interleukin-6. Each one of these can have genetics that make them run stronger. Then it stimulates an enzyme called NLRP3, Which makes what are called inflammasomes. Now, guess what inflammasomes can be? Your best friend or your worst enemy? Because they will, if you’ve got, again, a virus or bacteria, or possibly even some bad cells in the body. They will zap them. Well, that’s good. Unless it’s overactive. Unless it’s overactive. And then what it does, through interleukin-1 beta, makes excess glutamate. And then what it does, through interleukin-1 beta, makes excess glutamate. Anxiety, gut inflammation, OCD, ADD, autism. And, you know, glutamate, we’ll talk about that a little bit, but glutamate makes you intelligent, highly motivated go-getter. but can also be excitatory. And then, look what it does. Let’s see, do I have the drawing tool here? Yes, I do. Okay. So, it comes down through here, Makes the glutamate. Comes back up through here. through the ADORA 2A enzyme, Then we’ve got a feedback loop that feeds upon itself. Then, through interleukin-18, we make histamine. and mast cells. And then through histamine receptor site number 1, we come back and spin it. And now you’ve just got this spinning feedback loop. So, the glutamate will make you anxious, the histamine will give you allergies and make you anxious. And you’re allergic to everything, and you’re feeling horrible. Now, it doesn’t end there, Dr. Dad. It then goes on to make something called gast dermins that creates pyroptosis, where it actually starts punching a hole in the cell membrane. And you’re only going to be as healthy as your cells are. Just a little background. You know, we’re made up of trillions of cells, and each one of them has what’s called a lipid bilayer, made from lipids, which comes from fats. And you’re only going to be as healthy as those membranes are. So that’s why we coined an interesting phrase. Cellular CPR. Construct the cell. Protect the cell. And restore the cell membrane. And we believe that’s going to be revolutionary in the functional medicine world. So… It’s not hard to figure out that if you start punching holes in the cell membrane, that’s not a good thing, okay? Bob Miller 00:31:22 Now… There’s an interesting molecule called NAD. Thicotide adenoside dinucleotide. And anybody who’s in the, you know, listening to the health podcasts and things, they’re… They’re, they’re learning about NAD. And I’m going to show you a chart later, all the good things that NAD does, but For the most part, it helps what’s called sirtuins. And sirtuins are quite interesting. If anybody’s looking at longevity. The sirtuins is where they’re looking at.Because sirtuins turn on good things. Turn off bad things. And I’ll show some charts on that later. So for right here, this sirtuin uses NAD, to slow down NF-kappa-B. CERT 2 uses NAD to slow down an ORP3. So, if we’ve got genetic weakness on these, or we don’t have enough NAD, We don’t hold this pathway back. Make sense? Dr. Deb Muth 00:32:24 Yeah, makes perfect sense. Bob Miller 00:32:25 Now, I’ll show this a little bit later. So, people are like, oh, well, I’m gonna start taking some NAD. Dr. Deb Muth 00:32:31 Right. Bob Miller 00:32:32 And there’s functional doctors who give NAD intravenous. It was just this morning, I was talking to a woman who said, Oh my gosh. I went and got intravenous NAD, and it took me a month to recover from that. Dr. Deb Muth 00:32:45 Hmm. Bob Miller 00:32:46 what happens is, and I’ll show this in a little more detail, there’s an enzyme called CD38, that’s stimulated by NF-kappa-B. And it takes NAD, To make intracellular calcium. that stimulates NLRP3 and actually makes things worse. So, if we have this guy upregulated, and I’ll show a chart what does that. taking NAD will make you worse. Again, when I go into the software, I’ll show you that whole pathway, so… I would encourage people, you know, just don’t go out and start taking massive amounts of NAD, you know, stick your toe in the water, see how you do. Because everything you’ve heard about, how good it is, is true, unless this guy says, oh, thank you very much, let me make more inflammation. Now, this might be part of our innate immune system, that if we have some pathogen that’s gonna kill us. By golly, we want that to happen. But if this is happening by environmental factors, Then it’s detrimental. So the immune system that protected us a thousand years ago now might be turning on us because of the environmental factors that we showed earlier. All right. Then there’s an enzyme called PARP that’s NAD-dependent, and that actually repairs strain breaks in your DNA. Now, the next thing that happens… is there’s an enzyme called NADPH oxidase that gets stimulated. and something called INOS. Now, I’m sure most people know about nitric oxide. It’s a gas that dilates your blood vessels. That’s why sometimes they’ll even give people drugs, nitroglycerin, to boost their nitric oxide. That’s why people are doing beetroots and other things to boost their nitric oxide. But there’s an OS3 enzyme that makes the nitric oxide that’s good for blood flow. But there’s an INOS That makes nitric oxide to kill pathogens. probably might be the third or fourth time I’ve said this. That’s a good thing, unless it isn’t. So, if it’s killing some pathogen, great. It was just misfiring. it combines… With superoxide that’s made by this enzyme, and makes something called peroxynitrite, which is one nasty free radical that chews you up and spits you out. So, the NOx enzyme, NADPH oxidase, uses NADPH, To make this free radical called superoxide. If we have time, we’ll get into it. NADPH is what your body needs to recycle your antioxidants.So, I coined the phrase, the NADPH steel. Where the NOX enzyme takes this very important NADPH, And rather than being useful, makes superoxide. Now, again, is that fine if you’ve got some bacteria to kill? Of course. But if it’s just chronically running, it’s just making all this chronic inflammation. Then it makes something called hydrogen peroxide. And we need to clear hydrogen peroxide by 3 enzymes, catalase, thyroid reduction. And glutathione peroxidase. If we have genetic issues on here, or we don’t have the cofactors. There’s something called the Fenton reaction, discovered in 1895 by Dr. Fenton. Where hydrogen peroxide combines with iron to make what are called hydroxyl radicals. And guess what they do? They create lipid peroxides, That damages your cell membranes. Now, again, the body’s pretty darn amazing. We have glutathione, And here’s where your body’s taking glutathione and recycling it. But look who’s needed to recycle it. NADPH. So, if this guy up here is chewing it up, We don’t recycle our glutathione. And then an enzyme called glufon peroxidase 4, Takes this damaged lipid and repairs it. So, here we’ve got this protecting, we want to protect it by not having this happen. But then we also need this guy to do the restoration. So, there’s a lot that can go wrong in here, Dr. Deb. Dr. Deb Muth 00:37:07 There’s a lot that could go wrong. And I can imagine some of my listeners are thinking that lipid peroxidase, is that the same thing as what they’re thinking of when we talk about lipids and cholesterol? Is that the same process that’s happening there? Bob Miller 00:37:22 Well, no, no, the lipids can be used to make cholesterol, but here we’re talking about where they’re going to build the cell membrane. And they’re being… and they’re being, destroyed. If anybody would like to see a visual representation of this, just go on YouTube. And type in, ferrooptosis Animation. cool little video, it’s about 3 minutes long, and it shows the lipids coming over, being oxidized, and now GPX4 fixes them, so… YouTube, Pharaoptosis Animation, cute little video. It’s just that really… Shows vividly what we’re… what we’re talking about here. Now, this is… Dr. Deb Muth 00:37:59 And so this is very common, too. Like, a lot of people do hydrogen peroxide IVs. Dr. Deb Muth 00:38:04 And so, if somebody doesn’t know their genetics, they could have a problem with doing those, just like they could doing the NADHIVs, correct? Bob Miller 00:38:13 Sure, yeah, yeah, yeah. So, I’ve talked to so many, you know, of course, the hydrogen peroxide kills pathogens. I mean, that’s what it does. So… but I’ve spoken to so many people that said. I had one client that said they’ve never been the same after having one hydrogen peroxide infusion. Dr. Deb Muth 00:38:30 Interesting. Bob Miller 00:38:31 Yeah. So… it can be… I see why people use it, because it. Bob Miller 00:38:36 pathogens, But on the other hand. And now’s a good time to speak about… I don’t have it on here, but there’s a, there’s an enzyme called the HFE gene. And that is what causes you to absorb iron. And there’s mutations in it that cause something called hemochromatosis. Were you overabsorb iron? Now, true hemochromatosis is when both parents give you a mutation. But there’s now growing evidence even a heterozygous can cause a little bit more iron absorption, not to the human chromatosis point, but overabsorption. So, if you overabsorb iron, And you have too much hydrogen peroxide that’s not cleared, All kinds of inflammation. Now, what’s happened is sometimes this inflammation Will damage the red blood cells. And some well-meaning doctor says, oh, you need some iron. And they take iron and it makes it worse. So, can’t tell you how many people I’ve said, you’ve got the overabsorption of iron, and they say, well, that can’t be right, because I’m low in iron. Well, that could be because it’s being chewed up here. Dr. Deb Muth 00:39:40 Sure. GPX1 and TXN turn it into, to water. The, catalase turns it into water and oxygen. Dr. Deb Muth 00:39:58 Now, I see a lot of my clients who have mutations or SNPs on that GPX gene, on that glutathione gene. And they really struggle to clear a lot of their toxins. Bob Miller 00:40:12 Sure. Dr. Deb Muth 00:40:14 Yeah, absolutely. Well, GPX4. Bob Miller 00:40:18 is what, repairs, but you can see GPX1 Is what uses glutathione. To turn hydrogen peroxide. So, but it all depends upon having enough glutathione. Dr. Deb Muth 00:40:30 Yeah. Bob Miller 00:40:31 Well, guess who controls making a glutathione? Dr. Deb Muth 00:40:34 Nerf 2. Bob Miller 00:40:37 So, if you have a keep one weakness, or strength to two… I’m sorry, keep one is too strong. Nrf2 is too weak. You don’t make glutathione. So, when a lot of people do that, it’s like, well, I’m gonna take glutathione. Dr. Deb Muth 00:40:51 Right. Bob Miller 00:40:52 And some do great, and some do poorly. You know, because… and I’ll show this on one of the other charts. You can see here that the, The glutathione has to be recycled. And if we don’t recycle it, it actually turns into superoxide free radical. So… NADPH are the cofactors, For taking the oxidi… here’s oxidized glutathione, here’s reduced. So, this is a good glutathione. After it does its job, you can see it becomes oxidized.We need to recycle it. Well, if we have weakness on the enzyme that does that, or a weakness in Nrf2, or not enough NADPH. The oxidized glutathione never gets recycled. So, I’ve talked to a lot of people who said, oh, glutathione made me so sick, and say, well. Dr. Deb Muth 00:41:43 Yeah. Bob Miller 00:41:44 You need it, but you need to recycle it. Dr. Deb Muth 00:41:46 Can you speak for just a brief moment, too, about MTHFR? That is a very popular gene, it’s all over social media as the major gene, but can you speak to a little bit about that, and how that fits into this whole process of things? Because it is just such a small piece. Dr. Deb Muth 00:42:04 understanding genetics. Bob Miller 00:42:06 Yeah, to be honest, it drives me nuts. Dr. Deb Muth 00:42:08 Me too. Bob Miller 00:42:11 Alright, so… You know, there are people on social media I won’t say what I think, I’ll be kind. But… But the, And, you know, they might mean well. But they talk about, if you have MTHFR and COMT and PEMT, that’s… oh my goodness, that’s horrible, and we’ll fix that for you, and you’ll be fine. Bob Miller 00:42:36 it just irritates me to no end. And it really could get anybody who’s doing this legitimately in trouble. I mean, I’m afraid someday, you know, there might be some cracking down on this kind of nonsense. Now, to answer your question about MTHFR. Dr. Deb Muth 00:42:51 I mean, it really is, but I’ll tell you what, why don’t we hold that thought until I go to another map and I can actually… Okay. Bob Miller 00:42:56 But the real… the cliff notes is the MTHFR puts a methyl group on your folate, which is needed, but it has gotten way, way, way too much attention. And people learn they have MTHFR, and they start taking a multivitamin with methylfolate, then they take a B vitamin with methylfolate. Dr. Deb Muth 00:43:13 And they’re pushing it too hard. Bob Miller 00:43:15 Yeah. So I can’t tell you how many people I’ve helped by saying, stop it. Dr. Deb Muth 00:43:20 Yeah, take less of it. Bob Miller 00:43:21 Take less of it, yeah. So, yeah. Yeah, there’s a… If somebody, say, ranked the enzymes at their level of importance, MTHFR might be 40 or 50 on a scale of 100, you know. Keep one Nerf two. big deals. Dr. Deb Muth 00:43:40 deals. Bob Miller 00:43:41 NQO1 that I didn’t even talk about yet, NQO1, takes your, NA… your NAD goes into NADH, To make electrons for the electron transport chain. you need NQ01 to bring that back. If that’s not working, and I’ll show you on the NAD map how disastrous that can be. Now, the next piece is here, and I think You know, if you talk to any school teachers and say, if you’ve taught for more than 10 years, how are the kids today? Every one of them says, more ADD, ADHD, more autism. Just look at human beings, we’ve never been so agitated. You know, everybody, and it might be a social media thing, but people take a position on something, and if anybody doesn’t share that position, they view them as the enemy. Dr. Deb Muth 00:44:29 And it’s kind of scary what’s happening to us. Bob Miller 00:44:33 So, we can’t agree to disagree anymore. We see anybody who has a differing opinion as the enemy. And, you know, there was… there’s people that didn’t have Christmas dinners together, because they had political differences, like… Dr. Deb Muth 00:44:44 Excuse me. Bob Miller 00:44:45 can’t you put your political differences aside to have Christmas together, you know? Dr. Deb Muth 00:44:49 Right? Bob Miller 00:44:50 become that, you know, no matter what your position is, and I’m not saying anyone’s right or wrong, I’m just saying. You know, in the old days, they used to say that the Republicans and Democrats in Congress would argue policy and then go have dinner together. And now everybody’s all up in arms, angry. Dr. Deb Muth 00:45:05 Yeah. Bob Miller 00:45:06 So… There’s likely multiple reasons for that. But let me show you one of them. That, you know, to what degree this is… very important, we don’t know, but I think We’re beginning to believe this is very important. So, there’s something… there’s a neurotransmitter called GABA. And God buys the don’t worry, relax, be happy. Chill. Okay. Dr. Deb Muth 00:45:31 Nobody has enough of that anymore. Bob Miller 00:45:33 Well, yeah, you’ll be surprised what I’m gonna show you. So, let me see if I can find a, Let me see if I can find the right slide here. Let me look for it here. So, there’s something called a GABA receptor site. And here you can see… This is a neuron, and this is where you, The neuron normally is excitatory. However, there’s normally low chloride in the neuron. Dr. Deb Muth 00:46:09 Hmm. Bob Miller 00:46:10 So, GABA itself is neither relaxing. For excitatory, all GABA does, it opens up what’s called a chloride channel. And then chloride, which has a negative charge, will flow into the neuron. Follow me there? Dr. Deb Muth 00:46:26 Yep. Bob Miller 00:46:27 And as it does, it changes this from a positive charge to a negative charge, And it’s relaxing. and inhibitory. Dr. Deb Muth 00:46:34 Hmm. Bob Miller 00:46:36 Now, on the other hand, there’s enzymes called NKCC1, That will push chloride in. and KCC2 that will bring chlor… oops and bring chloride out. And then there’s a sodium channel. And, sodium has a positive charge. And glutamate will push that in. So, as long as this is happening. And GABA says, receptor sites, open, chloride goes in, Chill. However, If NKCC1 Pushes extra chloride in. KCC2 doesn’t pull it out. and GABA hits the receptor site, the GABA comes flowing out, Sodium comes in, And now it’s excitatory. So Gabba didn’t change. GABA just opened the receptor site, that’s all it does. Dr. Deb Muth 00:47:33 Yeah. Bob Miller 00:47:34 But it’s the chloride balance that’s going to determine whether this is relaxing or not. Now, these are the things that go along with when they lose that KCC2 or gain NKCC1. Pain and sensitivity, burning electrical, neuropathic pain. Normal touch hurts. Sound and light sensitivity. Tinnitus can flare. Headaches and migraines. Seizure tendency. Body jolts. Spasticity, cramps, stiffness, startle reflex. Trouble falling asleep, non-restorative sleep. Anxiety, stress, reactivity, that’s what we have now. Hyperarousal, panic-like surges, irritability, racing thoughts. Brain fog, slowed processing, working memory slip-ups. Mental fatigue. Episodes of racing hearts, sweaty palms, guts on edge. Those are all the things that happen when this GABA switch occurs. Now, here’s what happens, and this is what I’m going to be presenting at an autism conference. When you have a newborn, they need that NKCC dominant to develop. By early childhood, it should… or, sorry, early adulthood. we should move over to the KCC dominant, that’s the taking the chloride out. Nice-looking 25-year-old boys, functioning very well. However, when we get microglia M1 upregulated. Because of environmental toxins, processed foods, Tylenol, aluminum. they stay in NKCC1 dominant, and there’s ADD, ADHD, Autism, the whole spectrum. because… They’ve not moved over to the… They’ve not moved over to the KCC2. And again, this is caused by… Environmental factors. Stimulating the microglia. And then, interleukin-1, interleukin-18 weakens KCC2, interleukin-1 beta, Strengthens NKCC1. high chloride. We open up the chloride channel, In Rebell Excitatory. So, I think when, When the pediatricians get ahold of this, they’re going to be very excited to know that This could be why we’re seeing such a rise, and not just autism, but ADD, ADHD, anxiety, the whole shit mess. Dr. Deb Muth 00:49:58 thing. Bob Miller 00:49:59 Yeah, so… and you can see NF-kappa-B stimulates that. These stimulate it, and I think that’s why everyone’s getting so anxious. Now, there’s a little bit more to it, and we’ll get into this when we look at some of the maps, but… The, the glutamate, Which is excitatory. will stimulate the NMDA receptor, make more glutamate, And glutamate will inhibit KCC2. And then we also need an astrocyte To, take both ammonia And glutamate, and… Turn them back into glutamine. And I’m going to talk to you a little bit about arachidenic acid, and if we have too much arachidenic acid. or TNFA is upregulated, that doesn’t happen. Ammonia goes up, and there may be multiple reasons for this, but this is a reason why some of the autistic kids do flapping. Dr. Deb Muth 00:50:49 Hmm. Bob Miller 00:50:50 Because they’re not clearing their ammonia. And you can tell if somebody has high ammonia by… they get that old person smell, you know. Dr. Deb Muth 00:51:00 Yup. Bob Miller 00:51:01 your vehicle cycle’s not taking out the, the ammonia. Now, last pathway here. There’s growing interest in mast cell activation. So, back here, we talked about peroxynitride. And that will stimulate mast cells, and those are white blood cells that are your best friend, unless they’re your worst enemy. Then it’ll make histamine. And there’s enzymes called histidine decarboxylase that’ll make more. Dr. Deb Muth 00:51:28 I’m sure everybody’s heard of DAO, the enzyme that degrades histamine. Yep. Bob Miller 00:51:31 We can have genetic weakness, we don’t make that. There’s an enzyme called histamine and methyltransferase, That, That breaks down the histamine. Then if we don’t do that, it’ll get stuck in the histamine receptor site. And then it’ll make something called, renin. Which will cause angiotensinogen to turn into angiotensin. One, that turns into angiotensin II,And that’s where people make aldosterone, where they’ll get the, The swollen ankles and high blood pressure. But interestingly, there’s an enzyme called ACE2, that takes this guy and turns it into angiotensin 1-7, Which is anti-inflammatory and also inhibits… TNFA. Now, you can have weakness on ACE2, But… and anybody’s saying, that sounds familiar? Dr. Deb Muth 00:52:25 That’s where COVID comes in, using ACE2. Bob Miller 00:52:28 And now we just found there’s literature that if you get COVID long enough, it can actually make ACE2 not be able to work as well. So look what it does. It comes down here, stimulates the NADPH oxidase, More superoxide. More peroxynitrite. And we’re on a cycle here. We’ve actually named this the Home Cycle Hypothesis, the proposed feed-forward loop. That just keeps feeding on itself. All being caused by… Primarily, The environmental factors. But hitting those who have genetic weakness the hardest. That’s why. Dr. Deb Muth 00:53:08 To the people. Bob Miller 00:53:09 Don’t live in a moldy house. One person is sick as can be, and the other person says, well, you must be imagining things, because I don’t feel anything. Dr. Deb Muth Yeah. Same thing with long haul, right? Two people can both get sick, one gets sick and never seems to recover, and somebody else gets sick, and they have absolutely no problems with it at all. Bob Miller 00:53:30 Sure. Well, think about it, if you get COVID, and ACE2 is weak, and some of this other stuff is going on. This thing just starts feeding upon itself. Dr. Deb Muth 00:53:38 Keep creating more inflammation, more complications, nothing’s calming down. Bob Miller 00:53:43 Yeah. Now, you, you ask about, MTHFR. So, this is the, this is the, the software called Functional Genomic Analysis. There’s a demo report we have. So, let’s talk a little bit about, MTHFR. So, we actually have a map called a methylation map. Now, what happens is, when you do your saliva test, you, you know, you spit, you put some saliva. in a collection kit, goes to a lab, takes out the DNA data, sends it to the computer, and now you can actually see it visually. Okay. So, it’s gonna take a second for this, data to load up, it’s, and each of these Circles, each of these ovals, is an enzyme. And the data gets loaded up to see where it is. So, until it gets loaded up here, I didn’t preload this. There it goes. So… The primary thing about methylation is There’s a nasty substance called homocysteine that, if it’s too high, can really be detrimental. The body takes methylfolate, and combines with methyl B12, To bring this back up to methionine. And then through the MAT genes, we make SAMI, S-adml methionine. Which is involved in so many processes. Then after it does its thing, it turns back into homocysteine. And this thing needs to keep spinning around. That’s why, you know, it’s a good idea to keep homocysteine at, do you have a number that you’d like? 7, 8? What do you like for a number? Dr. Deb Muth 00:55:24 Yeah, I like mine below 7. Bob Miller 00:55:26 Yeah. So if the homocysteine goes too high. It, caused all kinds of problems. So, here’s where you ask about the MTHFR. So, here you can see on this individual. I click on MTHFR, and you can see it comes up here, here’s the C677. And you can see here where it says, variants. I’ll… I’ll draw in case somebody’s having a hard time seeing that. So, you can see there’s nothing in there. That means there’s no genetic mutations. If one parent would have given a mutation, there’d be a 1. If both parents did, there’d be a 2. Now, here’s why Yes, methylation is important, I’m not saying it isn’t important, but look at this MTHFRC677. In my software. Only 42.5% of the population does not have a mutation. 44.7% have won. 12.9 have 2. So, this isn’t some rare, oh my god, I’m gonna die… Kind of thing, yeah. Dr. Deb Muth 00:56:27 Right. Bob Miller 00:56:28 So, And then what happens is that, and again, I’m not dismissing methylation, I… we could do a whole show on methylation. Bob Miller 00:56:36 get it. But I think that what people are doing is they’re, they’re learning about MTHFR, they get it measured, they panic. They start taking massive amounts of methylfolate, which many times is to their detriment. Dr. Deb Muth 00:56:50 Well, it’s… and isn’t it true, too, with MTHFR, like, you have to also look at MTR, MTRR, and the more we stack up of those, the more complicated than MTHFR can be. It’s not… it’s not as simple as just saying MTHFR 677 versus 1298. It’s more complex than that, kind of like what you’ve already shown with some of the other things. There’s more to it than just that one little sliver. Bob Miller 00:57:17 Oh, sure, well, let’s take a look. So, remember I said there’s a cofactor? One of the cofactors is called FAD. Just a Bob Miller observation, that’s all. But when people have trouble with their riboflavin and they don’t have enough FAD, They’re doing much worse than people who have just a C677. So, right here, you could have perfect C677th. And if you don’t have the cofactor, it’s not gonna work, okay? Dr. Deb Muth 00:57:48 And as you said, there’s an MTR enzyme. Bob Miller 00:57:51 that takes methylfolate and methyl B12, to spin it around. So, here on this individual. here’s your… here’s your B vitamins, or I’m sorry, your B12s. There’s an enzyme called TCN1 that takes it from the stomach into the blood. Then there’s other enzymes that take it from the blood into the tissue. And if you’re having trouble here. Well, then you’re not going to have this working, so… Even if you don’t have MTHFR, And you have MTR, like this, no, I’m sorry, this person doesn’t. But they have the MTRR, and then they don’t have enough B12, this isn’t gonna work, aside from that. And then there’s a middle pathway. And then there’s enzymes called the MAT1. they take the methionine to the salmon. If that’s not working, we stick… we get stuck in methionine. So, it’s, it’s not just an MTHFR. And then, one of the things that people forget about. is through these CBS enzymes and CTH, We make cysteine, which is needed to make glutathione. The master antioxidant. So, it really is that… I call it the, The 3D chess game played underwater. Dr. Deb Muth 00:59:07 It really is. I mean, I see people who have CVS, COMT, glutathione, MGHFR genes. And some of them function just fine. Like, they have Like, I look at this person and I’m like, oh my gosh, I don’t know how they’re functioning because they’re double mutated on so many pathways, but yet they don’t have a lot of symptoms, they don’t have a lot of complications. Somehow their body has figured out a way to adapt to what it has so it can stay alive and it can function at a high functioning level. Bob Miller 00:59:36 Yeah, and they may be, you know, eating right? Yeah. Staying out of a moldy house. reducing stress. So, it’s diet, it’s stress, it’s genetics, environmental factors. So, yeah, we can’t just say somebody’s gonna be good or somebody’s gonna be bad. You know, some people get scared, oh, I got all these, it’s like, well… Bob Miller 00:59:56 Are you living in a moldy house? You know, and if you live in a moldy house and your glucuronidation pathway doesn’t do well, or if you’re, you know, a smoker, or you’re constantly eating junk food, I mean, all. Bob Miller 01:00:07 things come together. Although, you know, when we focus on genetics, we’re well aware that this is just a piece of it. You know, you could have identical twins, Genetically, and if one… Is exposed to mold and smokes and drinks and stressed out. They’re gonna be a whole lot sicker than their sibling. Bob Miller 01:00:28 Yep. Dr. Deb Muth 01:00:29 Yeah, it’s that concept of taking twins, and one gets raced with one family, and one gets raced with another family, and they don’t have the same… problems that… that each other have, you know? It’s a very unique situation, we don’t think about that enough. Bob Miller 01:00:44 Alright, so again, genetics loads the gun, environment pulls the trigger. So, if you’ve got a loaded gun, but you don’t have the triggers, you’re okay. Dr. Deb Muth 01:00:53 Yeah. Bob Miller 01:00:54 Yeah. So, remember I said I was going to talk about NAD? So, here’s NAD, and what it does, it turns into NADH. And what NADH does, it, Comes down this pathway, what’s called the electron transport chain. And that makes your ATP, that’s your energy. So, if this wasn’t working, we wouldn’t be alive, because we wouldn’t have energy. So it donates an electron, that’s why it’s called electron transport chain. So, we need NAD, To make this, to make the energy. But remember I said that NQ01, this would probably be, like, on my top 10 list of… Bob Miller 01:01:36 Much more important than MTHFR. This one takes NADH back to NAD. If we’re stuck over here, We’re low in this NAD+, But what happens is, NQO1 also provides CoQ10. And CoQ10 Is what’s needed for the electron transport chain to flow. So if we get too many electrons up here. And they don’t turn them into energy. They make a nasty free radical called superoxide. Okay. Now, NAD plus also makes NADPH, And that is needed. Remember I said we need to recycle our antioxidants. So, if we have a problem with FAD from riboflavin. Yeah, we don’t have enough NADPH, Glutathione’s not getting recycled, and you’re gonna be inflamed. And you take glutathione, you’ll feel worse. There’s another enzyme called thimoredoxin. Same thing, needs NADPH and FAD. And same way with your nitric oxide, there’s an enzyme called NOS3, That makes the nitric oxide that dilates your blood vessels. And if we don’t have enough NADPH or fat, You’re gonna make superoxide. Rather than nitric oxide. Now, remember

In this episode, Dr. Jockers breaks down the five nutrient deficiencies most closely linked to memory loss, brain fog, and Alzheimer's disease. You'll learn why these deficiencies are more common than most people realize and how they can impact cognitive health long before a diagnosis occurs.   You'll discover the warning signs of low magnesium, vitamin D, and vitamin B12, along with the role each nutrient plays in supporting healthy brain function. The conversation also explores key lab markers that may reveal hidden deficiencies affecting memory, mood, and focus.   You'll also learn how folate and vitamin B6 influence neurotransmitters, inflammation, and long-term cognitive health. Plus, you'll hear practical strategies for identifying nutrient gaps and supporting your brain through targeted nutrition and lifestyle changes.   In This Episode:  00:00 B12 Aging Warning 00:16 Podcast Welcome 04:18 Top Deficiencies Overview 05:33 Magnesium Brain Calm 08:43 Magnesium Labs And Fixes 14:02 Vitamin D, Mood And Labs 18:40 B12 Dementia Mimic 23:20 B12 Causes And Absorption 27:19 B12 Labs Foods Supplements 31:40 Folate Dementia Risk 37:45 Folate Supplements MTHFR 39:04 Vitamin B6 Neurotransmitters 41:54 B6 Labs Foods Dosing 43:46 Wrap Up And Next Steps   If you want practical, natural strategies to balance your hormones, heal your gut, boost your energy, and slow aging, don't miss The Dr. Josh Axe Show. Dr. Axe blends ancient wisdom with cutting-edge science and brings on world-class experts for unfiltered conversations you won't hear anywhere else. Transform your health from the inside out and subscribe to The Dr. Josh Axe Show, with new episodes every Monday and Thursday. If you're feeling wired, tired, and depleted, it's time to replenish your electrolytes with Relyte from Redmond. Made with Redmond's Real Salt, this clean formula provides essential electrolytes like sodium, potassium, and magnesium without any sugar or artificial ingredients. Perfect for those under stress, fasting, or living an active lifestyle, Relyte helps restore hydration, improve energy, and support mental clarity. Visit RedmondLife.com/DrJockers and use code JOCKERS for 15% off today!   Support your heart, brain, and immune system with Paleovalley's Wild Caught Fish Roe, a whole food source rich in Omega-3s like EPA and DHA. It's more bioavailable and stable than traditional fish oil, offering benefits for cardiovascular health, mood, and brain function. Go to paleovalley.com/jockers for 15% off your order!   Support your gut-hormone balance and curb cravings naturally with Wonder Biotics, a clinically proven, doctor-formulated probiotic featuring Bifidobacterium B420. Feel less bloating and reduce cravings within 3–6 months. Save 10% using code DRJOCKERS10 at wonderbiotics.com   "Red light therapy on the thyroid for 10 minutes a day helped nearly 75% of women reduce or stop their thyroid meds."   Subscribe to the podcast on: Apple Podcast Stitcher Spotify PodBean  TuneIn Radio   Resources:  Get 15% off at RedmondLife.com/DrJockers using code JOCKERS. Save 15% at Paleovalley.com/Jockers with code JOCKERS. Save 10% using code DRJOCKERS10 at wonderbiotics.com     Connect with Dr. Jockers: Instagram – https://www.instagram.com/drjockers/ Facebook – https:/www.facebook.com/DrDavidJockers YouTube – https://www.youtube.com/user/djockers Website – https://drjockers.com/   If you are interested in being a guest on the show, we would love to hear from you! Please contact us here! - https://drjockers.com/join-us-dr-jockers-functional-nutrition-podcast/

Well-known as the leader of the carnivore diet, Dr. Anthony Chaffee – medical doctor and neurosurgical expert joins Trending with Timmerie. Episode Guide Gut health and carnivore (1:11) Does the type of meat you consume matter? (18:57) I’m low on DHA. What should I do? (22:15) Recommendations for getting enough protein (24:38) Why would I need protein shakes? (35:09) Is beef better than pork? (38:19) How do you eat more protein when meat is expensive? (41:34) Cholesterol? (49:30) Resources mentioned: Previous shows with Dr. Anthony Chaffee: https://relevantradio.com/?cat=23210&s=chaffee Dr. Chaffee www.dranthonychaffee.com Harvard study on Carnivore/Ketosis and depression https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2022.951376/full Dr. Chaffee’s social media: @anthony_chaffee Food Resources: Ayoba Droewors https://ayobafoods.com/collections/bundles

In this episode, Nicolle W. Davis, PhD, RN, SCRN, FAHA, Director of the Mobile Stroke Program at UF Health, and Janice Walker, DHA, MBA-HCM, NEA-BC, BSN, RN, System Nursing Officer and Senior Vice President at UF Health, join the podcast to discuss the development of stroke protocols and the growth of innovative mobile stroke programs. They share how bringing specialized stroke care directly to patients can improve outcomes, reduce treatment delays, and strengthen coordinated care across the health system.

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Tom Dayspring is a world-renowned lipidologist and one of the most thoughtful teachers in the field of lipid metabolism. In this episode, Tom returns to The Drive for a deep dive into the relationship between lipids and brain health, beginning with the fundamentals of cholesterol transport before exploring why the brain's cholesterol system operates almost entirely independently from the rest of the body. Tom examines the roles of apoB, apoA-I, and especially apoE in cholesterol homeostasis, discusses how APOE genotype influences Alzheimer's disease risk, and unpacks the complex links between cholesterol metabolism, amyloid, and tau pathology. He also reviews what is currently known—and still uncertain—about the effects of statins, ezetimibe, omega-3 fatty acids, and emerging CETP inhibitors on brain health and neurodegenerative disease risk. Although highly technical, this conversation provides an essential framework for understanding the nuanced relationship between lipid-lowering therapies, cardiovascular disease prevention, and neurodegenerative diseases in an area often clouded by misinformation. We discuss: The fundamentals of cholesterol transport in the body, and how peripheral cholesterol metabolism differs from cholesterol handling in the brain [2:45]; How cholesterol is transported through plasma and stored within cells, and why lowering LDL cholesterol does not deplete the body or brain of cholesterol [11:45]; How apoB particles drive atherosclerosis, why lowering lipids matters, and the factors that influence individual cardiovascular risk [20:00]; How the brain produces and transports its own cholesterol using apoE lipoproteins independently of circulating cholesterol and apoB-containing lipoproteins [29:00]; How apoB structure influences LDL receptor binding and LDL clearance [39:00]; How neurons acquire cholesterol from apoE-containing lipoproteins and why desmosterol serves as a unique marker of cholesterol synthesis in the brain [41:45]; The difference between the APOE gene and the apoE protein, the major APOE genotypes found in humans, and how APOE4 influences Alzheimer's disease risk [48:45]; HDL function beyond cholesterol: immune function, protein cargo, and communication with the brain [53:30]; How APOE4-associated defects in brain cholesterol transport may promote Alzheimer's disease: amyloid production, neuronal cholesterol homeostasis, and cholesterol clearance [58:00]; Statins and brain health: reviewing the evidence of the potential impact of statins on cognition and Alzheimer's disease risk [1:09:00]; Desmosterol and 24S-hydroxycholesterol as biomarkers of brain cholesterol metabolism and statin effects [1:17:15]; Possible cognitive benefits of ezetimibe beyond lowering apoB [1:19:30]; EPA, DHA, and the evidence for omega-3 fatty acids in brain health [1:23:15]; Obicetrapib: an emerging CETP inhibitor with potential implications for both cardiovascular and brain health [1:31:00]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube

The “Enhanced Games”, with no-holds-barred performance-enhancing drugs, yields scant advantages over “clean” contests; Does saturated fat increase insulin resistance? Can a heart attack victim avoid statin use with CoQ10? Omega-3 fish oil shows promise vs. type 2 diabetes; Motorized e-scooter use needs to be regulated NOW!

There is a 45% chance the fish oil sitting in your cabinet right now is already oxidized. And rancid omega-3s do not just fail to help you. Research shows they generate pro-inflammatory byproducts that work against everything you are taking fish oil for. Dr. G breaks down exactly how this happens, how to test what is in your cabinet tonight with zero equipment, and what to actually look for before you buy another bottle. In this episode, you will learn:  • The two oxidation markers most brands count on you never knowing about, the peroxide value and the anisidin value, and the total oxidation score that tells you whether your fish oil is actually fresh  • Why the number on the front of your fish oil bottle is not the amount of omega-3s you are getting, and the simple math that reveals whether you have been underdosing for years  • The at-home test you can do right now with one capsule, a pin, and 30 seconds that will tell you immediately whether to keep your fish oil or throw it away Plus the specific brands that passed Dr. G's independent investigation for certificate of analysis standards, packaging, storage, meaningful EPA and DHA doses, and proper oxidation scores. Timestamps: 0:00 - Intro 1:00 - The George Washington University Study That Exposed What's on Shelves  1:46 - Peroxide Value, Anisidine Value & the TOTOX Score Explained  2:18 - Why Fish Oil Is One of the Most Chemically Fragile Supplements You Can Buy  3:10 - What Legitimate Brands Do to Protect Their Oil (And What to Look For)  3:39 - The Label Scam: 1,000mg of Fish Oil Is Not 1,000mg of Omega-3s  4:24 - What a Clinically Meaningful Dose of EPA and DHA Actually Looks Like  5:09 - Three Questions to Ask Any Fish Oil Brand Before You Buy  7:00 - How to Test the Fish Oil in Your Cabinet Right Now  8:08 - The Brands That Passed Dr. G's Investigation Learn more about your ad choices. Visit megaphone.fm/adchoices

What if the health of your food starts long before it reaches your plate?   In this episode of the ReThink Health Podcast, Dr. Eric Berg and I explore the fascinating connection between soil health, regenerative farming, nutrient density, metabolic health, and the ketogenic diet.   Dr. Berg shares his personal journey from being a self-described "junk food junkie" struggling with severe health issues… to discovering low-carb nutrition, healthy keto, and the powerful role food quality plays in long-term wellness.   But this conversation goes far beyond keto.   We dive deep into the modern food system, why regenerative farming may produce more nutrient-dense meat, how soil microbes influence plant and animal health, and why the quality of the food you eat may matter just as much as the macros.   You'll learn:   Why Dr. Berg says going vegan was "the sickest time" of his life Why bioavailable nutrients like vitamin A, iron, zinc, DHA, and protein may be harder to obtain from plants alone The difference between "healthy keto" and simply eating low carb How soil health may directly influence plant, animal, and human health The hidden problems with conventional agriculture, glyphosate, hormones, antibiotics, and grain-fed livestock What Dr. Berg's regenerative beef testing revealed about omega-3s, inflammation markers, phytonutrients, and metabolic health How keto and intermittent fasting may support weight loss, mood, energy, blood sugar, and metabolic health   If you've ever wondered how modern food production affects human health, this episode offers a thought-provoking look at the connection between agriculture, metabolism, and wellness.   VALUABLE RESOURCES Paleovalley Bone Broth Protein   >>> Support whole-body repair with clean, glycine-rich protein from 100% grass fed bone broth. Save up to 20% today on Paleovalley Bone Broth Protein.   Dr. Eric Berg is a doctor of chiropractic, natural health educator, bestselling author, and one of the most widely recognized voices in ketogenic nutrition and intermittent fasting.   After struggling with his own health issues in early adulthood, Dr. Berg became deeply interested in nutrition, metabolism, insulin resistance, and holistic health. Over the last several decades, he has educated millions of people on topics including keto, fasting, metabolic health, nutrient density, hormones, gut health, and regenerative agriculture.   Dr. Berg is also a regenerative farmer who studies the relationship between soil biology, food quality, and human health. His work explores how farming practices may influence nutrient density, inflammation, microbiome diversity, and chronic disease risk.   Through his books, educational content, and massively popular YouTube channel, Dr. Berg has helped millions better understand the connection between food, metabolism, and overall wellness. THANKS FOR LISTENING!   Thanks so much for joining us this week! Have feedback or a question? Email us at support@paleovalley.com. We'd love to hear from you!   If you enjoyed this episode, please share it with someone who might benefit from the information.   Following the ReThink Health Podcast on YouTube, Spotify, or iTunes helps us reach more people who need to hear this and keeps you updated on new episodes.   Likes, subscribes, ratings, and reviews are incredibly helpful and deeply appreciated… we read every single one!   Let's spread this knowledge and help others together. See you next time!   Click below to follow on YouTube, Spotify or iTunes: Don't miss the podcast…   Vegan Diet Nearly Destroyed My Health – Here's What I Eat Now (that's healed 10,000+) with Dr. Eric Berg. In this episode, Dr. Eric Berg explores how soil health and regenerative farming affect our food… and what that could mean for inflammation, metabolism, energy, and long-term health.   >>> Support whole-body repair with clean, glycine-rich protein from 100% grass fed bone broth. Save up to 20% today on Paleovalley Bone Broth Protein.  

In this episode, Dr. Jockers sits down with Dr. Josh Axe to explore advanced cellular healing strategies for thyroid, hormones, and metabolism. You'll learn why most thyroid issues aren't caused by the thyroid itself and how targeting the gut, liver, adrenal glands, and mitochondria can reverse hypothyroidism naturally. Discover practical ways to balance hormones, manage menopause and PMS symptoms, and support healthy metabolism with simple lifestyle changes, nutrient strategies, and targeted herbs. Dr. Axe shares insights on mitochondrial health, liver support, and dietary adjustments that make a real difference. We also cover actionable steps to boost energy, curb cravings, and improve vitality through hydration, probiotics, personalized nutrition, and supporting your cellular systems. Listen closely for tips that can transform how your body feels and functions every day.   In This Episode:  00:00 Thyroid Root Causes 03:18 Cellular Healing Intro 05:14 Reverse Hypothyroidism 08:37 Warmth Light Therapy 11:24 Mitochondria Support Hacks 17:41 Yogurt Pomegranate Desserts 20:57 Women Hormones Overview 22:27 Menopause Stress Reset 30:20 Menopause Diet Herbs HRT 33:50 Cell Membranes Cancer Link 36:19 Repairing Cells With Fats 36:54 Ditching Seed Oils 38:59 Liver Hormone Connection 40:48 Saturated Fat Nuance 43:42 Personalized Nutrition Plans 45:22 Liver Detox Strategies 46:49 PMS and PCOS Protocols 49:20 Boosting Male Testosterone 54:39 Relationships and Hormones 59:26 Birth Control Thyroid Risks 01:02:05 Longevity Clinic Therapies 01:05:01 Wrap Up and Resources   If you want practical, natural strategies to balance your hormones, heal your gut, boost your energy, and slow aging, don't miss The Dr. Josh Axe Show. Dr. Axe blends ancient wisdom with cutting-edge science and brings on world-class experts for unfiltered conversations you won't hear anywhere else. Transform your health from the inside out and subscribe to The Dr. Josh Axe Show, with new episodes every Monday and Thursday. If you're feeling wired, tired, and depleted, it's time to replenish your electrolytes with Relyte from Redmond. Made with Redmond's Real Salt, this clean formula provides essential electrolytes like sodium, potassium, and magnesium without any sugar or artificial ingredients. Perfect for those under stress, fasting, or living an active lifestyle, Relyte helps restore hydration, improve energy, and support mental clarity. Visit RedmondLife.com/DrJockers and use code JOCKERS for 15% off today!   Support your heart, brain, and immune system with Paleovalley's Wild Caught Fish Roe, a whole food source rich in Omega-3s like EPA and DHA. It's more bioavailable and stable than traditional fish oil, offering benefits for cardiovascular health, mood, and brain function. Go to paleovalley.com/jockers for 15% off your order!   Upgrade your cooking with 100% grass-fed beef tallow from Kettle & Fire—seed oil-free, high smoke point, and packed with flavor while supporting liver and overall health. For a limited time, get 25% off sitewide, including tallow and bone broth, using code DRJOCKERS at kettleandfire.com/drjockers. Available at select Sprouts, Whole Foods, and Kroger stores nationwide. Support your gut-hormone balance and curb cravings naturally with Wonder Biotics, a clinically proven, doctor-formulated probiotic featuring Bifidobacterium B420. Feel less bloating and reduce cravings within 3–6 months. Save 10% using code DRJOCKERS10 at wonderbiotics.com   "Red light therapy on the thyroid for 10 minutes a day helped nearly 75% of women reduce or stop their thyroid meds."   Subscribe to the podcast on: Apple Podcast Stitcher Spotify PodBean  TuneIn Radio   Resources:  Get 15% off at RedmondLife.com/DrJockers using code JOCKERS. Save 15% at Paleovalley.com/Jockers with code JOCKERS. Get 25% off sitewide, including tallow and bone broth, using code DRJOCKERS at kettleandfire.com/drjockers Save 10% using code DRJOCKERS10 at wonderbiotics.com     Connect with Dr. Josh Axe: Website: https://draxe.com/ Podcast: https://podcasts.apple.com/us/podcast/the-dr-josh-axe-show/id1700689487 Instagram: https://www.instagram.com/drjoshaxe     Connect with Dr. Jockers: Instagram – https://www.instagram.com/drjockers/ Facebook – https:/www.facebook.com/DrDavidJockers YouTube – https://www.youtube.com/user/djockers Website – https://drjockers.com/   If you are interested in being a guest on the show, we would love to hear from you! Please contact us here! - https://drjockers.com/join-us-dr-jockers-functional-nutrition-podcast/

In this episode:• The childhood disease cod liver oil helped reverse• Why Weston A. Price believed modern diets changed facial structure within one generation• The connection between vitamin A, D, K2, DHA, bones, teeth, and babies• Why traditional cultures protected special foods for women before pregnancy• How mouth breathing and jaw development compound over time• Why cod liver oil is not the same thing as regular fish oil• The real lesson behind the “smelly spoonful” our grandparents were told to takeWhat did we remove from the modern diet, and what did it quietly cost us?

→ Get My Brand Masterlist: ⁠⁠https://drchristiangonzalez.com/best-brands-form-2-2/⁠⁠ Episode Description In 2025, researchers published what may be the most important longevity study of the decade. Three years. Over 2,000 participants. A randomized controlled trial. And the results stopped the researchers themselves. A 61% reduction in invasive cancer risk. A 39% reduction in becoming physically frail. And measurable slowing of biological aging, verified by epigenetic clocks, the most sophisticated tool science has for measuring how fast your cells are actually aging. These were not elite athletes. They were regular older adults. And the three things that produced these results are inexpensive, accessible, and available at any supplement store. Most people are either missing them entirely or doing them in a way that produces almost no benefit. Dr. G breaks down exactly what the study found and what you need to do with it. In this episode, you'll learn:  • Why omega-3 deficiency carries a mortality risk comparable to smoking, and the specific EPA and DHA dose that the research shows actually slows biological aging at the cellular level  • Why vitamin D is not optional if you exercise, and why low vitamin D means the training you are already doing is producing a fraction of the benefit it should  • Why the combination of all three produces results that are not additive but multiplicative, and what that means for anyone over 40 who wants to change their biological trajectory The window that matters most is not when you are 60. It is now. Timestamps: 0:00 - Intro 1:38 - Why This Study Deserves Your Attention (And Why No One Is Talking About It)  3:02 - Who This Episode Is For: Men Over 40 and the People Who Love Them  4:45 - The Deficiency Crisis: Most People Are Missing All Three Interventions  6:29 - Thing #1: Why Low Levels Are as Dangerous as Smoking  8:44 - Thing #2: The Pro-Hormone Your Muscles and Immune System Are Waiting For  10:37 - Thing #3: The One Thing That Is Not Optional for Healthy Aging 13:22 - What Happens When You Do All Three Together (The Numbers Are Dramatic)  14:48 - Exactly What to Take, How Much & How Often Learn more about your ad choices. Visit megaphone.fm/adchoices

In this Her Stack series episode, I open up about maternal mental health, postpartum anxiety, and the invisible biological load mothers carry long after the six-week checkup is over. This episode is not just for the newly postpartum mother. It is for the mother whose kids are four, eight, fifteen, and still asking herself why she does not feel like herself. I share why motherhood structurally changes the brain, hormones, and nervous system, and why so many mothers are left feeling anxious, foggy, depleted, or unlike themselves without ever being properly screened or supported. I walk you through the science of the postpartum neurosteroid withdrawal, the gray matter changes that persist for years, and the five-system map underneath maternal brain fog. Then I break down the full four-pillar protocol I use with my one-to-one clients: foundational nutrition, lifestyle and biohacking tools, the supplement layer including some of the most under-discussed compounds for the maternal brain, and the advanced peptide layer including Semax, Selank, NAD+, and bioregulators. This is the episode every mother needs. Send it to one. Join The LongHer Life for women-specific guidance on peptides, hormones, and longevity. I TALK ABOUT:  02:00 - My free peptide masterclass for moms next week 04:10 — Why maternal mental health is not just a six-week postpartum issue 06:30 — The numbers every mother should know (and the screening gap that explains everything) 08:20 — How pregnancy structurally changes the brain (Nature Neuroscience, 2017) 11:40 — The neurosteroid withdrawal nobody warned you about, and the FDA's $34,000 drug that proves it is real 13:50 — Pillar 1: DHA, protein, ferritin, blood sugar stability, and methylated Bs for the maternal brain 22:40 — Pillar 2: Protected sleep cycles, morning sunlight, vagal nerve activation, and red light to the brain 28:00 — Yoga nidra and NSDR as the workaround for mothers who cannot engineer a protected sleep cycle 32:45 — Simplifying routines, meals, outfits, and planning to reduce mental load 35:00 — Co-regulation: Why one hour of real adult conversation is medicine 38:40 — Creatine for maternal mental health, depression support, and cognitive fatigue in sleep-deprived moms 40:50 — Saffron and inositol for postpartum mood, anxiety, racing thoughts, and the "can't shut off the brain" symptoms 42:15 — Magnesium L-threonate, glycine, vitamin D, and low-dose methylene blue for sleep, brain fog, mitochondrial support, and nervous system balance 45:25 — Why peptides are an advanced layer and should come after nutrition, lifestyle, and supplement foundations 46:10 — Semax and Selank for anxiety, cortisol support, BDNF, dopamine, brain fog, memory, and maternal brain support 50:00 — NAD+ and bioregulators (Cortagen, Cerluten, Epithalon) for maternal energy, neuronal support, circadian rhythm, melatonin, sleep, and long-term brain health 58:15 — Why postpartum anxiety and depression need different kinds of support, and why SSRIs work for some mothers and not others 1:00:00 — Why lingering symptoms matter and which labs mothers should check RESOURCES: Labs to ask your provider for: TSH, free T3, free T4, reverse T3, ferritin, vitamin D, DHA panel Join The LongHer Life for women-specific guidance on peptides, hormones, and longevity. Free Peptide Masterclass for Moms: Join the waitlist for the next live class. The Her Stack Planner: The first peptide tracking journal built around female biology. Crisis support: 988 in the US, 988 in Canada PRODUCTS MENTIONED: Supplements DHA (omega-3) Creatine monohydrate Saffron (Crocus sativus extract) Inositol (myo + d-chiro blend) Glycine Magnesium L-threonate (BiOptimizers code: BIOHACKINGBRITTANY) Vitamin D Lion's mane mushroom Bacopa monnieri Methylated B vitamins (methylcobalamin, methylfolate, P5P) Methylene blue (low dose, pharmaceutical USP only) Peptides Semax Selank NAD+ options NOVOS code: BIOHACKINGBRITTANY Nuchido TIME+ code: BIOHACKINGBRITTANY Nasal spray (Synchronicity Health code: BIOHACKINGBRITTANY) Bioregulators Cortagen Cerluten Epithalon LET'S CONNECT: Instagram, TikTok, Facebook Shop my favorite health products Listen on Spotify, Apple Podcasts, YouTube Music

In this episode, Dr. Jockers sits down with Michael Cohen to explore how neurofeedback can help retrain the brain's "electrical software" to improve anxiety, sleep, focus, and emotional balance. You'll learn why nutrition alone may not fully resolve brain fog or nervous system dysregulation, and how the brain can be trained to create healthier patterns.   Michael breaks down how chronic stress, trauma, overstimulation, and poor nervous system regulation can keep the brain stuck in survival mode. You'll discover how different areas of the brain influence mood, attention, overwhelm, and emotional reactivity—and how targeted brain training may help restore balance.   You'll also hear powerful stories of transformation involving ADHD, autism, concussion recovery, anxiety, and trauma healing. This conversation dives into the connection between sleep, brain health, emotional resilience, and the tools that may help people finally feel calm, focused, and mentally clear again.   In This Episode:  00:00 Neurofeedback Success Story 00:34 Interview Setup and Goals 03:38 Meet Michael Cohen 04:28 Brain Software vs Nutrition 06:18 How Neurofeedback Trains 07:28 Sympathetic Overdrive Explained 10:38 Tools to Reset Calm 12:49 Neurofeedback Process Demo 16:12 Brain Areas and Targets 18:27 Electrodes and Brain Mapping 23:53 Case Study and Root Causes 25:55 Mold EMF and Sleep Tips 27:03 Simple Timer Hack 27:16 NFL Brain Recovery Story 29:45 Concussions and Brain Timing 31:42 Nutrition Plus Neurofeedback 34:33 Beyond Pharmaceuticals 35:41 Autism Case Breakthrough 37:20 Trauma and Lasting Healing 42:54 Finding Neurofeedback Help 44:18 Home Training and New Tools 45:09 Brain Entrainment and Devices 47:27 Wrap Up and Sleep Priority 49:53 Final Thanks and Outro   If you want practical, natural strategies to balance your hormones, heal your gut, boost your energy, and slow aging, don't miss The Dr. Josh Axe Show. Dr. Axe blends ancient wisdom with cutting-edge science and brings on world-class experts for unfiltered conversations you won't hear anywhere else. Transform your health from the inside out and subscribe to The Dr. Josh Axe Show, with new episodes every Monday and Thursday. If you're feeling wired, tired, and depleted, it's time to replenish your electrolytes with Relyte from Redmond. Made with Redmond's Real Salt, this clean formula provides essential electrolytes like sodium, potassium, and magnesium without any sugar or artificial ingredients. Perfect for those under stress, fasting, or living an active lifestyle, Relyte helps restore hydration, improve energy, and support mental clarity. Visit RedmondLife.com/DrJockers and use code JOCKERS for 15% off today! Support your heart, brain, and overall wellness with Paleovalley's Wild Caught Fish Roe. This whole food source of Omega-3s is rich in EPA and DHA, helping to reduce inflammation and promote brain function. Take control of your health today and save 15% on your purchase at paleovalley.com/jockers with the code JOCKERS.   If you've ever been told your labs look "normal" while still dealing with brain fog, low energy, poor sleep, or unexplained symptoms, I highly recommend checking out SuperPower Health. They go far beyond standard blood work with over 100 biomarkers from one simple blood draw, giving you real insight into your hormones, metabolism, inflammation, nutrient status, toxins, and overall health. I also love that they track your results over time and give you access to an on-demand clinician team right through their app. Head to SuperPower.com and use code JOCKERS to save $20 off your membership. Healthy skin starts at the cellular level, which is why I'm a big fan of OneSkin. Their products were developed by longevity researchers using a proprietary peptide called OS-01, designed to target senescent cells and support healthier, younger-looking skin from the inside out. The science behind this is incredibly impressive, with multiple clinical studies and thousands of five-star reviews backing the results. Visit OneSkin.co/drjockers and use code DRJOCKERS to get 15% off your order today.   "When your nervous system is balanced, everything works better—sleep, focus, mood, and relationships."   Subscribe to the podcast on: Apple Podcast Stitcher Spotify PodBean  TuneIn Radio   Resources:  Get 15% off at RedmondLife.com/DrJockers using code JOCKERS. Save 15% at Paleovalley.com/Jockers with code JOCKERS. Save $20 on your membership at SuperPower.com using code JOCKERS. Get 15% off at OneSkin.co/DRJOCKERS using code DRJOCKERS.     Connect with Michael Cohen: Website:  centerforbrain.com Book: Neurofeedback 101 https://a.co/d/08t1Dul6 Book: The Mind Rewired https://a.co/d/08meFNFP     Connect with Dr. Jockers: Instagram – https://www.instagram.com/drjockers/ Facebook – https:/www.facebook.com/DrDavidJockers YouTube – https://www.youtube.com/user/djockers Website – https://drjockers.com/   If you are interested in being a guest on the show, we would love to hear from you! Please contact us here! - https://drjockers.com/join-us-dr-jockers-functional-nutrition-podcast/

In this episode, Dennis Campbell II, DHA, RN, FACHE, President, ECU Health Beaufort - a campus of ECHUMC, discusses the future of rural healthcare, workforce development, and expanding access to high-quality care close to home. He also shares leadership insights from his journey as a bedside nurse to hospital president and highlights the importance of purpose-driven leadership, innovation, and community connection.

In this episode, Dr. Jockers sits down with Dr. Chris Motley to uncover the hidden signs of parasite infections and how they may be impacting your sleep, energy, digestion, mood, and metabolism. They break down why so many people unknowingly carry parasites and the symptoms that are often overlooked.   You'll discover how parasites thrive in toxic environments, where they tend to hide in the body, and why issues like gut dysfunction, stress, and poor detoxification can make infections harder to overcome. The conversation also explores the connection between parasites, mood changes, and nervous system health.   The episode also dives into natural parasite-cleansing strategies, including the most effective herbs, detox practices, lymphatic support techniques, and lifestyle habits that help the body heal and become more resilient long term.   In This Episode:  00:00 Parasites And Neck Pain 02:14 Dad's Mystery Illness 03:02 Radionics And Liver Clues 05:49 Gallbladder Meridian Breakthrough 07:53 Where Parasites Hide 11:30 Common Parasites Sources 13:12 Key Symptoms To Watch 14:15 Why Some Get Sicker 16:22 Toxins Metals And Load 17:22 Trauma Liver And Parasites 21:35 Testing Options And Limits 24:22 Blood Markers And Patterns 29:09 Herbs And Homeopathics 31:11 Herb Cycling Strategy 31:54 Roundworm Protocol Basics 32:55 Blastocystis Remedies 36:28 Mimosa Pudica Velcro 37:39 Parasite Proof Stories 41:11 Full Moon Cleanse Timing 46:46 Eggs Lymph Drainage 50:38 Binders And Constipation 51:41 Preventing Reinfection 54:39 Wrap Up And Outro   If you want practical, natural strategies to balance your hormones, heal your gut, boost your energy, and slow aging, don't miss The Dr. Josh Axe Show. Dr. Axe blends ancient wisdom with cutting-edge science and brings on world-class experts for unfiltered conversations you won't hear anywhere else. Transform your health from the inside out and subscribe to The Dr. Josh Axe Show, with new episodes every Monday and Thursday. If you're feeling wired, tired, and depleted, it's time to replenish your electrolytes with Relyte from Redmond. Made with Redmond's Real Salt, this clean formula provides essential electrolytes like sodium, potassium, and magnesium without any sugar or artificial ingredients. Perfect for those under stress, fasting, or living an active lifestyle, Relyte helps restore hydration, improve energy, and support mental clarity. Visit RedmondLife.com/DrJockers and use code JOCKERS for 15% off today! Dealing with fine lines, dull skin, or skin that just doesn't look as healthy and vibrant as it used to? The Bon Charge Red Light Face Mask is an easy way to support healthier, younger looking skin right from home. It uses red and near infrared light therapy to help improve skin elasticity, reduce visible signs of aging, calm inflammation and redness, and support a clearer, more radiant complexion. It's lightweight, cordless, and only takes about 10 to 20 minutes a day to use. Right now, you can get 15% off your order plus free shipping and a 12 month warranty when you go to boncharge.com and use promo code DRJOCKERS at checkout. Fuel your body with clean, high-quality protein from ButcherBox. They deliver 100% grass-fed beef, free-range organic chicken, crate-free pork, and wild-caught seafood straight to your door—making it easy to support your energy, metabolism, and overall health. For a limited time, get your choice of chicken breast or top sirloin for a year, or ground beef for life, plus $20 off your first box. Visit ButcherBox.com/DrJockers to claim this special offer. Support your heart, brain, and overall wellness with Paleovalley's Wild Caught Fish Roe. This whole food source of Omega-3s is rich in EPA and DHA, helping to reduce inflammation and promote brain function. Take control of your health today and save 15% on your purchase at paleovalley.com/jockers with the code JOCKERS. "Parasites are masters at hiding. They can trick your body into thinking they belong there while silently draining your energy."   Subscribe to the podcast on: Apple Podcast Stitcher Spotify PodBean  TuneIn Radio   Resources:  Visit RedmondLife.com/DrJockers and use code JOCKERS for 15% off today! Visit boncharge.com and use promo code DRJOCKERS at checkout for 15% Visit ButcherBox.com/DrJockers to claim this special offer Save 15% on your purchase at paleovalley.com/jockers with the code JOCKERS.     Connect with Dr. Chris Motley: Website: https://www.doctormotley.com/     Connect with Dr. Jockers: Instagram – https://www.instagram.com/drjockers/ Facebook – https:/www.facebook.com/DrDavidJockers YouTube – https://www.youtube.com/user/djockers Website – https://drjockers.com/   If you are interested in being a guest on the show, we would love to hear from you! Please contact us here! - https://drjockers.com/join-us-dr-jockers-functional-nutrition-podcast/

In this episode, Dr. Jockers sits down with Dr. Shivani Gupta to explore how inflammation is the root cause of many chronic health issues. Dr. Gupta shares her journey bridging Ayurvedic wisdom with modern science to reveal how super herbs and spices like turmeric can combat inflammation at its core. You'll learn how Ayurveda identifies unique body types or doshas and how this understanding can help tailor your nutrition and lifestyle to reduce inflammation. Dr. Gupta explains how aligning with your body's natural rhythms and using personalized nutrition strategies can create lasting health benefits. Dr. Gupta also dives into the power of gut health, highlighting how an imbalanced gut can fuel systemic inflammation. Tune in to discover practical Ayurvedic practices that support digestive health and reduce inflammation, including tea time rituals and stress management techniques.   In This Episode:  00:00 Inflammaging Not Aging 00:24 Meet Dr Shivani Gupta 05:49 Interview Begins Book Origins 08:31 What Is Chronic Inflammation 11:17 Gut Health And Leaky Gut 13:38 Ayurvedic Daily Gut Rituals 15:51 Elemental Design Doshas 17:44 Vata Pitta Kapha Explained 23:10 Dosha Blends And Balance 27:06 Foods For Each Dosha 28:58 Cooling Summer Foods 29:39 Kapha Balancing Diet 30:19 Finding Your Dosha 31:03 Menopause as Vata Season 32:44 Mental Inflammation 36:57 Circadian Rhythm Basics 39:02 Tea Time Mindfulness 40:51 Nighttime Sleep Routine 46:29 Deep Sleep Tea Herbs 47:10 Super Spice Protocols 52:41 Turmeric Absorption Tips 54:20 Cycling Supplements 55:48 Final Takeaways   Support your heart, brain, and overall wellness with Paleovalley's Wild Caught Fish Roe. This whole food source of Omega-3s is rich in EPA and DHA, helping to reduce inflammation and promote brain function. Take control of your health today and save 15% on your purchase at paleovalley.com/jockers with the code JOCKERS. If you want practical, natural strategies to balance your hormones, heal your gut, boost your energy, and slow aging, don't miss The Dr. Josh Axe Show. Dr. Axe blends ancient wisdom with cutting-edge science and brings on world-class experts for unfiltered conversations you won't hear anywhere else. Transform your health from the inside out and subscribe to The Dr. Josh Axe Show, with new episodes every Monday and Thursday. If you're feeling wired, tired, and depleted, it's time to replenish your electrolytes with Relight from Redmond. Made with Redmond's Real Salt, this clean formula provides essential electrolytes like sodium, potassium, and magnesium without any sugar or artificial ingredients. Perfect for those under stress, fasting, or living an active lifestyle, Relight helps restore hydration, improve energy, and support mental clarity. Visit RedmondLife.com/DrJockers and use code JOCKERS for 15% off today! It's time to take your oral care to the next level with BON CHARGE's Red Light Toothbrush – order yours today! For a limited time, my listeners get 15% off when you order from boncharge.com and use my exclusive promo code DRJOCKERS at checkout You'll also get free shipping and a 12-month warranty. Go now to get this exclusive offer! That's boncharge.com with promo code DRJOCKERS to get 15% off   Ensure pure, clean water with CovePure's advanced filtration system. It removes up to 99.9% of contaminants, including harmful PFAS, heavy metals, and fluoride, so you can enjoy safe, toxin-free water. For a limited time, get $250 off your order at covepure.com/drjockers. Momentum Shake is a game-changer, replacing multiple supplements with one simple scoop. Packed with collagen, hyaluronic acid, and Lion's Mane for cognitive support, it boosts your energy, mental clarity, and strength without the overwhelm of complex routines. Get your free welcome kit and travel collection worth $70 at momentumshake.com/drjockers. "Most people don't have an aging problem, they have an inflammation problem driven by diet, stress, and toxins stacking over time."     Subscribe to the podcast on: Apple Podcast Stitcher Spotify PodBean  TuneIn Radio   Resources:  Support heart, brain, and overall wellness with Paleovalley's Wild Caught Fish Roe and save 15%: https://paleovalley.com/jockers Enjoy pure, clean water with CovePure's advanced filtration system and get $250 off your order: https://covepure.com/drjockers Simplify your supplement routine with Momentum Shake and get a free welcome kit and travel collection worth $70: https://momentumshake.com/drjockers Stay hydrated with Redmond Life's Relight electrolytes and experience better energy, clarity, and strength: https://redmond.life/drjockers Improve your oral health with Bond Charge's Red Light Toothbrush and enjoy free shipping and a 12-month warranty: https://bondcharge.com/drjockers   Connect with Dr. Shivani Gupta: Book: ​​https://a.co/d/01YI6LXr   Connect with Dr. Jockers: Instagram – https://www.instagram.com/drjockers/ Facebook – https:/www.facebook.com/DrDavidJockers YouTube – https://www.youtube.com/user/djockers Website – https://drjockers.com/   If you are interested in being a guest on the show, we would love to hear from you! Please contact us here! - https://drjockers.com/join-us-dr-jockers-functional-nutrition-podcast/