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Commentary by Dr. Jian'an Wang.
(7) Josiah Osgood describes the Civil War's onset as Caesar crossed the Rubicon, prompting Pompey and Cato to evacuate Italy for the East. Caesar utilized a strategy of clemency and maintained iron discipline, even executing mutineers in the Ninth Legion. After Pompey was defeated at Pharsalus and murdered in Egypt, Cato led the Republican remnant to Utica. Following Caesar's final victory in Africa, Cato refused to beg for mercy, choosing a graphic suicide to deny Caesar a political triumph. His death transformed him into a martyr, marring Caesar's victory and the future imperial regime.CLAUDIS BEGS FOR HIS LIFE
Send me a derm question or story through text or voicemail!A new JAK inhibitor has officially entered the veterinary market but where does it fit into managing allergic dogs?In this episode of The Derm Vet Podcast, I sit down with boarded veterinary dermatologist Dr. Christine McKinney from Merck Animal Health to discuss Numelvi, the newest JAK inhibitor approved in the United States for canine allergic dermatitis. We break down what makes this medication unique, how it compares to other allergy therapies, and why having multiple treatment options matters when managing complicated allergic patients.We also dive into practical approaches for itch control, infection management, and building confidence when treating chronic allergy cases in practice. If you manage itchy dogs regularly and want to stay up to date on the latest dermatology treatments, this episode is packed with valuable clinical insights.Watch The Episode: https://www.youtube.com/@thedermvet3932Follow The Derm Vet Podcast: https://www.instagram.com/thedermvetpod/Follow Me: https://www.instagram.com/thedermvet/Timestamps and references: 7:26: At the recommended treatment dose, Numelvi is at least 10X more selective for JAK1 over the other JAK enzymes in in vitro assays. Reference: Kowalski T, Schuette S. The second-generation Janus kinase inhibitor atinvicitinib is a potent and highly selective inhibitor of JAK1. Vet Dermatol. 2026;37(2):179.8:03: At the recommended treatment dose, Numelvi is at least 10X more selective for JAK1 over the other JAK enzymes in in vitro assays. Reference: Kowalski T, Schuette S. The second-generation Janus kinase inhibitor atinvicitinib is a potent and highly selective inhibitor of JAK1. Vet Dermatol. 2026;37(2):179.8:07: JAK1 is the primary driver of itch and inflammation. Reference: Huang I, Chung W, Wu P, Chen C. JAK-STAT signaling pathway in the pathogenesis of atopic dermatitis: an updated review. Front Immunol. 2022;13:106826010:36: At the recommended treatment dose, Numelvi is at least 10X more selective for JAK1 over the other JAK enzymes in in vitro assays. Reference: Kowalski T, Schuette S. The second-generation Janus kinase inhibitor atinvicitinib is a potent and highly selective inhibitor of JAK1. Vet Dermatol. 2026;37(2):179.21:52: Numelvi, starts reducing itch within 2-4 hours in a canine interleukin-31 (cIL-31)-induced pruritus model Reference: Kowalski T, Prohaczik A, Locke K, Samson C, Hope K. The second-generation Janus kinase inhibitor atinvicitinib significantly reduces pruritus 2-4 hours after dosing dogs in a canine interleukin-31 model. Vet Dermatol. 2026;37(2):179-180.23:13: Numelvi, starts reducing itch within 2-4 hours in a canine interleukin-31 (cIL-31)-induced pruritus model Reference: Kowalski T, Prohaczik A, Locke K, Samson C, Hope K. The second-generation Janus kinase inhibitor atinvicitinib significantly reduces pruritus 2-4 hours after dosing dogs in a canine interleukin-31 model. Vet Dermatol. 2026;37(2):179-180.Timestamps00:00 Intro02:29 The Complexity of Canine Allergic Dermatitis06:44 What is Numelvi and How Does it Work?13:50 Dosing Guidelines and Tablet Specifications16:57 Candidate Selection and Infection Control21:37 Onset of Action and Efficacy Timeline24:08 Final ThoughtsThis episode is sponsored by Merck Animal Health
Signs of focal epilepsy before the seizures start: hear all about it from neurologist and epileptologist Dr. Jacob Pellinen, who shares with us his research and results proving that people can experience things like depression or learning difficulties at school or work before seizure onset.Chapters
Jeremy Zakis discusses the onset of a "super El Niño" weather pattern impacting both the United States and Australia. While currently experiencing unusually wet and cold conditions in New South Wales, Australia is preparing for catastrophic drought and bushfires by December. The discussion highlights differences in fire management between California's forced evacuations and Australia's choice-based approach, emphasizing the danger of combustible eucalyptus trees near homes. Additionally, the weather has generated massive surf swells at Bondi Beach and unexpected early snowfall in the Southern Highlands and Victoria, signaling a potentially intense winter season ahead. (1/3)1916 NSW ANZAC DAY
On this episode of Citizen of the Week, we highlight the work of Karen Sandone whose husband was diagnosed with younger-onset Alzheimer's. This Doylestown woman chose to speak out and create a national community of support.
Most people think breast cancer treatment ends when the tumor is gone. Science says that's where the real damage often begins, and the woman making that argument was diagnosed at 28, lost her mother to ovarian cancer the same year, and turned her own dismissal by the medical system into a specialization that now treats women nobody else will touch. In this episode, I sit down with Dr. Corinne Menn Board Certified OBGYN, breast cancer survivor, and one of the few specialists in the world treating menopause in cancer survivors. We break down why 80% of women diagnosed with breast cancer have no strong family history, why tamoxifen and aromatase inhibitors quietly devastate brain, bone, and sexual health, and why telling a woman with severe vaginal atrophy to use coconut oil is not evidence-based medicine. Dr. Corinne also opens up about her own diagnosis, her premature menopause at 28, the truth about hormone replacement therapy after breast cancer, and the BRCA, ApoE4, and surgical menopause snowball nobody is putting together for patients. This conversation will completely change how you think about breast cancer, menopause, and the women's health crisis hiding in plain sight. Reduce your risk of Alzheimer's with my science-backed protocol for women 30+: https://go.neuroathletics.com.au/youtube-sales-page Subscribe to The Neuro Experience for evidence-based conversations at the intersection of brain science, longevity, and performance. _____ TOPICS DISCUSSED 00:00 Intro: Why Nobody Is Coming to Save Breast Cancer Survivors 01:05 Karin's Origin Story: Diagnosed at 28, Losing Her Mom, and Premature Menopause 03:06 The 85% Cure Rate Lie: Why Survival Comes at a Brutal Cost 06:13 Breast Cancer Is Not One Disease: Why 80% Have No Family History 08:14 BRCA1, BRCA2, and the Genetic Mutations Most Women Never Get Tested For 13:14 Karin's Own Genetic Test Story and Why 23andMe Is Not Enough 15:07 BRCA1 vs BRCA2: Age of Onset and When to Remove Ovaries 17:30 The Biology of Estrogen: Why Estrogen Does Not Cause Breast Cancer 23:40 Birth Control, Breastfeeding, and the Real Risk Factors 26:17 Alcohol, Inflammation, and the Toxins Driving Cancer Rates 27:46 Tamoxifen Explained: What It Does to Your Brain, Bones, and Body 34:23 Aromatase Inhibitors: Putting Your Estrogen in the Basement 37:15 Where Women Go When No Doctor Will Help Them 41:17 Oophorectomy, Early Menopause, and the 6 to 12% of Women Affected 44:26 Why Black Women Face the Highest Risk and the Least Care 46:20 The ApoE4, BRCA, and Surgical Menopause Snowball 48:02 Coconut Oil Is Not Medicine: The Vaginal Estrogen Truth 50:35 HRT Denial and the Myths Keeping Women From Treatment 51:13 Who Owns the Breast Cancer Survivor After Treatment Ends 54:18 Why the System Fails: Reimbursement, Resources, and Survivorship Gaps 01:00:07 Can You Be on Tamoxifen and Hormone Replacement Therapy? 01:03:26 Three Neurologists, One Tau Test, and the Dementia Dismissal 01:06:26 Positive Stories: Women Who Took Back Their Health and Won 01:09:16 The One Wish: Valuing Ovarian Function Beyond Reproduction _______ Thank you to our sponsors KetoneIQ: https://ketone.com/NEURO for 30% OFF DailyBasis: https://www.dailybasislife.com/NEURO for 50% off first month IQBARS: https://www.eatiqbar.com/ Biologica: https://biologica.com/NEURO Up to 32% off first subscription order Cure Hydration: https://www.curehydration.com/ Use code NEURO gets 20% off Honey Love: https://www.honeylove.com/NEURO Save 20% Off Honeylove #honeylovepod _______ I'm Louisa Nicola - clinical neurophysiologist - Alzheimer's prevention specialist - founder of Neuro Athletics. My mission is to translate cutting-edge neuroscience into actionable strategies for cognitive longevity, peak performance, and brain disease prevention. If you're committed to optimizing your brain- reducing Alzheimer's risk - and staying mentally sharp for life, you're in the right place. Stay sharp. Stay informed. Join thousands who subscribe to the Neuro Athletics Newsletter → https://bit.ly/3ewI5P0 Instagram: https://www.instagram.com/louisanicola_/ Twitter : https://twitter.com/louisanicola_ Learn more about your ad choices. Visit megaphone.fm/adchoices
Between 1918 and 1921, over a hundred thousand Jews were murdered in Ukraine by peasants, townsmen, and soldiers who blamed the Jews for the turmoil of the Russian Revolution. In hundreds of separate incidents, ordinary people robbed their Jewish neighbors with impunity, burned down their houses, ripped apart their Torah scrolls, sexually assaulted them, and killed them. Largely forgotten today, these pogroms—ethnic riots—dominated headlines and international affairs in their time. Aid workers warned that six million Jews were in danger of complete extermination. Twenty years later, these dire predictions would come true. Jeffrey Veidlinger's new book In the Midst of Civilized Europe: The Pogroms of 1918-1921 and the Onset of the Holocaust draws upon long-neglected archival materials, including thousands of newly discovered witness testimonies, trial records, and official orders, showing for the first time how this wave of genocidal violence created the conditions for the Holocaust. Join us for a discussion on this important new book featuring Jeffrey Veidlinger in conversation with Steven Zipperstein. This book talk originally took place on November 30, 2021. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/new-books-network
In this episode, we review the high-yield topic of Maturity Onset Diabetes of the Young from the Endocrine section.Follow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbullets
Between 1918 and 1921, over a hundred thousand Jews were murdered in Ukraine by peasants, townsmen, and soldiers who blamed the Jews for the turmoil of the Russian Revolution. In hundreds of separate incidents, ordinary people robbed their Jewish neighbors with impunity, burned down their houses, ripped apart their Torah scrolls, sexually assaulted them, and killed them. Largely forgotten today, these pogroms—ethnic riots—dominated headlines and international affairs in their time. Aid workers warned that six million Jews were in danger of complete extermination. Twenty years later, these dire predictions would come true. Jeffrey Veidlinger's new book In the Midst of Civilized Europe: The Pogroms of 1918-1921 and the Onset of the Holocaust draws upon long-neglected archival materials, including thousands of newly discovered witness testimonies, trial records, and official orders, showing for the first time how this wave of genocidal violence created the conditions for the Holocaust. Join us for a discussion on this important new book featuring Jeffrey Veidlinger in conversation with Steven Zipperstein. This book talk originally took place on November 30, 2021. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/jewish-studies
Between 1918 and 1921, over a hundred thousand Jews were murdered in Ukraine by peasants, townsmen, and soldiers who blamed the Jews for the turmoil of the Russian Revolution. In hundreds of separate incidents, ordinary people robbed their Jewish neighbors with impunity, burned down their houses, ripped apart their Torah scrolls, sexually assaulted them, and killed them. Largely forgotten today, these pogroms—ethnic riots—dominated headlines and international affairs in their time. Aid workers warned that six million Jews were in danger of complete extermination. Twenty years later, these dire predictions would come true. Jeffrey Veidlinger's new book In the Midst of Civilized Europe: The Pogroms of 1918-1921 and the Onset of the Holocaust draws upon long-neglected archival materials, including thousands of newly discovered witness testimonies, trial records, and official orders, showing for the first time how this wave of genocidal violence created the conditions for the Holocaust. Join us for a discussion on this important new book featuring Jeffrey Veidlinger in conversation with Steven Zipperstein. This book talk originally took place on November 30, 2021. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/eastern-european-studies
In this podcast, Vera Kaelin discusses her paper 'Involvement in daily life of children and young people with childhood-onset disabilities'. The paper is available here: https://doi.org/10.1111/dmcn.70228 Follow DMCN on Podbean for more: https://dmcn.podbean.com/ ___ Watch DMCN Podcasts on YouTube: https://bit.ly/2ONCYiC __ DMCN Journal: Developmental Medicine & Child Neurology (DMCN) has defined the field of paediatric neurology and childhood-onset neurodisability for over 60 years. DMCN disseminates the latest clinical research results globally to enhance the care and improve the lives of disabled children and their families. DMCN Journal - https://onlinelibrary.wiley.com/journal/14698749 ___ Find us on Twitter! @mackeithpress - https://twitter.com/mackeithpress
Interview with Iwona Koenig, PhD
Clare has recorded a major increase in electric car sales in the months since the onset of the Iran war. The latest figures from The Society of the Irish Motor Industry show 74 such vehicles were sold in the county in April, a 200% increase from the same month in 2025. Sales in hybrid models also jumped by just under 20% last month, with petrol-electric hybrids accounting for 43% of all cars sold in Clare this year. However, SIMI Director General, Brian Cooke, says nationwide figures are still below the level required to hit climate targets.
Commentary by Dr. Katsuhiko Imai.
Cntarctic Blasts and Economic Shifts in the Australian WinterGuest: Jeremy Zakis Summary: Jeremy Zakis describes a harsh onset of winter in Sydney, driven by cold Antarctic air funneled through a high-pressure corridor,. While Sydney faces near-freezing overnight temperatures, Tasmania recently recorded a record-breaking 70°F due to El Niño conditions and a southern warm front. The conversation also highlights the economic strain of soaring fuel prices, with diesel reaching approximately $8.85 per gallon, prompting many commuters to switch to public transport,. Despite these costs, consumer spending remains resilient as people shift toward online shopping, while domestic heating continues a transition from gas to electric and solar-powered systems,.1900 QNL
Caden shares the story of a 5-year old dog who, seemingly from one day to the next, developed fear and anxiety around noises in the dark.Get in touch with Caden: caden [dot] cristopher [at] gmail [dot] comhttps://adventuredogsanarchy.com/https://www.patreon.com/AdventureDogshttps://cadencristopher.bsky.social/Thank you ...to Lesfm for providing the royalty-free intro and outro music and to Isabelle Grubert for designing the show logo!
What starts as a childhood in East Los Angeles turns into a life shaped by gangs, prison, and violence. In this raw and unfiltered interview, a former Mexican Mafia member—Mundo—breaks down his journey from rebellion and low self-esteem to becoming deeply embedded in one of the most feared prison organizations in the United States. He shares firsthand stories about growing up in gang-infested neighborhoods, his first time in juvenile hall, and how prison culture transformed him. From brutal violence and survival tactics behind bars to the psychology of gang loyalty, identity, and fear—this is a rare inside look into a world few ever truly understand. In this episode: -Growing up in East LA and early influences -Why people really join gangs (it's not what you think) -First time in juvenile hall and adapting to survive -The moment everything changed: first homicide -Prison politics, race dynamics, and gang structure -The rise and influence of the Mexican Mafia -How violence becomes normalized behind bars -The reality of loyalty, fear, and identity in gang life This isn't glamorized. It's real. And it's a story about consequences. Go Support Mundo! Books: https://www.policeandfirepublishing.com/ YouTube: @convictsandcops Movie: https://www.amazon.com/Mundo-Vince-Romo/dp/B07MMP45GC This Episode Is #Sponsored By The Following: GLD! New customers get 40% Off with code MITCHELL at https://GLD.com Superpower! Head to https://superpower.com and use code CONNECT at checkout for $20 off your membership. Unlock your new health intelligence. 100+ biomarkers. Every year. Detect early signs of 1,000+ conditions. #superpowerpod BetterHelp! When life feels overwhelming, therapy can help. Sign up and get 10% off at https://betterhelp.com/connect Hims! To get simple, online access to personalized, affordable care for ED, Hair Loss, Weight Loss, and more, visit https://hims.com/connect Join The Patreon For Bonus Content! https://www.patreon.com/theconnectshow 00:00 Mundo's Violent Life Begins 02:00 Introducing Ramon "Mundo" Mendoza 03:30 Why Mundo Wears a Mask & His Early Life 06:30 Growing Up in Boyle Heights and Gang Culture 09:00 Juvenile Hall and the Onset of Violence 13:00 Gang Identity and Early Violence 17:00 Life in Juvenile Hall: Survival and Respect 20:38 This Episode Is Sponsored By GLD 22:13 First Major Gang Beefs & Beatings 26:00 Mundo's First Homicide and Its Impact 31:00 Retaliation, Machine Guns & Escalation 37:34 This Episode Is Sponsored By Superpower 39:01 Going to Prison: The Start of a New Chapter 44:00 Early Days in Prison: Riots and Survival 51:00 Prison Politics: Gangs, Drugs & Race 56:00 Murder in Prison and Evasion of Justice 58:35 This Episode Is Sponsored By BetterHelp 59:14 Killing Inside: Desensitization & Prison Life 01:10:00 From Prison Violence to the Outside World 01:14:12 This Episode Is Sponsored By Hims 01:15:44 Joining the Mexican Mafia: Becoming a Member 01:23:00 Life as a Made Member: Hits, Power & Respect 01:31:00 The Evolution and Expansion of La Eme 01:39:00 Organized Crime: Heroin, Money & Murder Inc. 01:47:00 Structure of Surenos & Influence Over California 01:54:00 La Eme, the Cartels, and National Influence 02:01:00 Collection, Power, and Street-Level Operations 02:07:00 The Murder Case That Changed Everything 02:15:00 Conversion, Remorse, and Turning Point 02:21:00 Leaving the Mafia & Finding a New Path 02:24:00 Becoming an Author & Outro Learn more about your ad choices. Visit podcastchoices.com/adchoices
Adult‑onset leukodystrophies, though rare, can closely mimic MS on both clinical presentation and neuroimaging, posing a significant diagnostic challenge. This episode highlights key clinical and radiologic red flags that can help distinguish these disorders from MS, preventing misdiagnosis and avoiding inappropriate treatment while enabling timely genetic counseling and targeted therapies. In this episode, Teshamae Monteith, MD, FAAN, speaks with Roberta La Piana, MD, PhD, coauthor of the article "Adult-Onset Leukodystrophies Mimicking Multiple Sclerosis" in the Continuum® April 2026 Multiple Sclerosis and Related Disorders issue. Dr. Monteith is the associate editor of Continuum® Audio and an associate professor of clinical neurology at the University of Miami Miller School of Medicine in Miami, Florida. Dr. La Piana is an associate professor in the Department of Neurology and Neurosurgery at the Montreal Neurological Institute, McGill University, and an associate member of the Department of Diagnostic Radiology at McGill University in Montreal, Quebec, Canada. Additional Resources Read the article: Adult-Onset Leukodystrophies Mimicking Multiple Sclerosis Subscribe to Continuum®: shop.lww.com/Continuum Earn CME (available only to AAN members): continpub.com/AudioCME Continuum® Aloud (verbatim audio-book style recordings of articles available only to Continuum® subscribers): continpub.com/Aloud More about the American Academy of Neurology: aan.com Social Media facebook.com/continuumcme @ContinuumAAN Host: @headacheMD Full episode transcript available here Dr Monteith: You just saw a patient in clinic. And you're clear, the diagnosis is multiple sclerosis. Not everything fits, but it kind of looks like multiple sclerosis. You see the patient back years later. There're some treatment issues, the patient's not responding to treatment, and things look different. Have you thought about a genetic inherited problem like leukodystrophy or a genetic white matter disorder? Listen to this podcast. We're going to help you figure it out. Dr Jones: This is Dr Lyell Jones, Editor-in-Chief of Continuum. Thank you for listening to Continuum Audio. Be sure to visit the links in the episode notes for information about earning CME, subscribing to the journal, and exclusive access to interviews not featured on the podcast. Dr Monteith: This is Dr Teshamae Monteith. Today I'm interviewing Dr Roberta La Piana about her article on adult-onset leukodystrophies mimicking multiple sclerosis, which she wrote with Dr Gabrielle Macaron. This article appears in the April 2026 Continuum issue on multiple sclerosis. Welcome to our podcast. Dr La Piana: Thank you. Thank you for having me. Dr Monteith: Absolutely. Why don't we start off with you introducing yourself? Dr La Piana: So, my name is Roberta La Piana. I'm a pediatric neurologist. I trained in Italy, I did my medical school, I did my residency in pediatric neurology there. And then I moved here to Montreal, to the Montreal Neurological Institute, to do a PhD in neuroscience. And that's where I specialized in adult-onset genetic white matter diseases. And after my PhD, I was recruited as an assistant professor here. So, that's where I got into this field. Dr Monteith: This big field, highly specialized; lots of disorders, but highly specialized. And what got you into this? Neuroscience is huge. So, was it a mentor, or…? Dr La Piana: No, actually, it was because of my background, because I trained as a pediatric neurologist and I loved the genetic white matter disorders in the pediatric population. So, when I came to the Montreal Neurological Institute, initially it was mainly to have a better expertise in imaging. And being at an adult neurology institute, I started seeing patients with adult genetic white matter diseases, and I was immediately fascinated by how different they were from their pediatric counterparts. Because in pediatric genetic white matter diseases, pediatric leukodystrophies look very diffuse, look very confluentous, so it's difficult to mistake them. But in adults, in the adult forms, I was initially driven by how often they can be misdiagnosed as multiple sclerosis or as other acquired white matter disorders. So that's why I got really interested in in this field. Dr Monteith: You're, like, literally the perfect person for this discussion. Dr La Piana: I'm not sure- *laughs* Dr Monteith: Why don't we start off with what your objectives were when writing this article? Dr La Piana: With writing this article, the goal is what I have been, actually, doing for the past ten years or so. So, really try to get more attention into the field because of the high rate of potential misdiagnosis of patients. So, that's exactly the reason why I really would like to raise the interest of neurologists for these disorders, because they are not considered enough in the differential diagnosis of patients, of adult patients presenting with white matter disorders. They are considered rare---which are, they are rare, definitely. But collectively, while each single form is rare, collectively they are not as rare. So- and thus, the risk of misdiagnosis and the potential impact of misdiagnosis on them with, you know, you can imagine giving patients inappropriate treatment or missing the possibility of a prenatal genetic diagnosis is so high that I really would like people to keep these disorders in the differential. Dr Monteith: And it sounds like more than ever, this is really important because some of the newer developments in the field. Dr La Piana: Yes. Specifically, we have now tools that will allow to diagnose these patients quite quickly. All the genetic techniques that are available nowadays can really, with one single shot, we can now sequence hundreds of genes so we can have a quicker diagnosis. And this thing was impossible up until ten years ago. So that's definitely the first huge improvement that makes these disorders now easily diagnosed. Dr Monteith: Yeah. So why don't we talk a little bit about how common is this misdiagnosis for these rare subtypes? Dr La Piana: Yeah, the misdiagnosis, it depends on the cohorts. Generally speaking, I would say that the rate of that misdiagnosis for these forms is up to 25% or even more in some other cohorts. And it really depends on the forms. Like, there are clearly some forms, especially those that present with multifocal white matter diseases, that present with nonspecific clinical presentations like migraines, image---and especially for female patients, and for which migraine is so common, having multifocal with other abnormalities is so common, the rate of diagnosis increases even further. So, these are all things that we need to keep in mind. I know these are rare, but still, we need to always have them on the back of our minds. Dr Monteith: Are there any particular disorders that are more often misdiagnosed? And you spoke about progressive forms of multiple sclerosis being a common kind of misdiagnosis. Dr La Piana: Yeah. So, there are definitely forms that are more commonly misdiagnosed. And these are those that, as I probably repeated already too many times, is the word multifocal, which is key. So, all those genetic white matter disorders that present with multifocal white matter abnormalities are not initially considered as genetic. So, I'm thinking about all of the leukovasculopathies, so, the small vessel diseases which are genetic in origin. For example, CADASIL; for example, the disorders related to collagen-4; so, the COL4 A1 or A2-related disorders. Those are clearly more commonly misdiagnosed initially. Another big group, unfortunately, is the CSF1R-related disorders. I know I'm saying a lot of gene names, but due to the fact that they start with multifocal abnormalities and they start with quite nonspecific, slowly progressive symptoms, the rate of misdiagnosis is definitely higher. Dr Monteith: And can you discuss some of the clinical challenges when seeing patients that might lead to this misdiagnosis? Dr La Piana: There are multiple clinical challenges. One is definitely the presence of nonspecific or initially mild clinical symptoms that sometimes don't raise initially the red flag of something, degenerative or progressive or genetic. One category that I would mention are psychiatric disturbances, especially in the form of depression, anxiety, or apathy. This is quite common in patients with some forms of genetic white matter disorders, and they are initially misdirected to psychiatrists and taken care in that domain. But it's only when some even mild neurological symptoms like a gait disturbance or hyperreflexia, or we had patients with, like, a urinary incontinence. It's only at that time, but maybe years have passed meanwhile, that these patients are finally referred to the neurologist Dr Monteith: You spoke about some of these clinical symptoms. Can you give us some other clinical red flags? Dr La Piana: Well, some other clinical red flags can be, for example, the extraneurological involvement. So, we have patients where- and there's a reason immediately to some specific disorders. For example, infertility. The presence of infertility in a female patient with white matter disorders should immediately form the consideration of the specific genetic white matter diseases that are associated with these forms. And this is not something that neurologists tend to ask about in the collection of the clinical history. And this is something that can make the difference and can accelerate the diagnosis. Dr Monteith: What are some other things? I mean, I know we can think about treatment, lack of a common treatment response, maybe, to steroids. You gave a great example of optic neuritis, for example. Give us some other things that we should say, hey, this doesn't fit the picture. Red flag. Dr La Piana: In this case, I think we want to talk more about the specific misdiagnosis of MS. Because these patients are often misdiagnosed with MS, but they might sometimes be misdiagnosed with other forms of acquired white matter diseases. When we consider MS, definitely the presence of being treatment resistant: so, patients that are not responsive to the common MS-targeting treatment should be always a red flag. The evolution as well. So, for example, the presence of a more slowly progressive course is another red flag. The presence of optic neuritis. Sometimes it's tricky because it's not common in the genetic white matter disorders, it's used as a criterion to orient correctly towards a multiple sclerosis. But we need to keep in mind that there are forms, genetic forms, especially the mitochondrial forms, that can present with optic neuritis and are really at the overlap with the multiple sclerosis spectrum. Then, if we want to move forward beyond the clinical side and go into the laboratory, of course a negative lumbar puncture with no oligoclonal bands should be a major red flag. Dr Monteith: What about some of the radiographic features? Dr La Piana: So, the radiographic features is something we are really working on in the field, especially with the new criteria used in MS. So, for example the paramagnetic rim lesions or the central vein sign, they are considered the specific forms. But it's true- and don't have an answer for that. I want to be clear, but it's true that they haven't been assessed yet extensively in patients with genetic white matter disorders. Anecdotally, I can say, because I have already reported this at conferences, that we have seen patients with genetic white matter conditions reaching a threshold for a central vein sign that can be considered diagnostic for MS. And we have seen that in some patients. Again, no study has been carried out extensively to date, but I think we should consider that with a grain of salt. But yeah, the paramagnetic rim in lesions is probably more accurate to distinguish between genetic and acquired white matter disorders. Dr Monteith: And what about some of the genetic white matter disorders that mimic MS? You spoke about things like CADASIL; what are other things that we should keep in the back of our mind? And you have great charts, to our listeners, and they're going to have to review those charts, because they're excellent. I think maybe they need to find a way to make that a little bookmark you walk around with on the ward. But what are some other conditions that kind of commonly mischaracterized? Dr La Piana: Two of the main groups are the one that you mentioned. So, leukovasculopathy is- so, CADASIL, is definitely one of the most common misdiagnoses of MS. And the presence, as we said, of some clinical features like migraine, especially when it's complicated migraine with visual aura, we all know that. But especially in the context of a positive family history for either a psychiatry condition or migraine as well, or strokes, these are all factors that should prompt the consideration of these disorders in the differential of a patient with white matter disorders. Another category are definitely mitochondrial disorders, which I think are more neglected than others because we don't think about mitochondrial disorders when we see white matter disease; we tend to consider that mitochondrial disorders are a problem of the gray matter, but they are not. There are white matter diseases that have definitely mitochondrial. And the third category are probably microgliocytes, which are represented by the CSF1R-related disorder. And this is also something that is clearly quite prevalent, relatively prevalent, in the field of genetic white matter disorders misdiagnosed as MS. Dr Monteith: Yeah. Why don't we go through some of the, kind of, key history, you know, some of the key questions you would ask in the history to try and differentiate? You mentioned kind of subtle symptoms, longstanding progressive symptoms. I know things that we look at like relapsing/remitting and some trigger factors can actually be associated with some of these genetic disorders. So how do you approach a patient? What are some of the key questions? You talked about family history and you talked about medical history, but why don't you kind of give us a nice way to kind of hone in on to the patient? Dr La Piana: There are a couple of questions that we usually ask. I should make a disclaimer, though, that I work very closely with the MS clinics, so we are ready to receive patients that are prescreened. So, these are already patients that people working on acquired white matter disorders feel like they are atypical, so they want our opinion. But usually, there are two groups of questions that we always ask. One is about the family history. And by saying family history, I really dig into the family history. I don't just want to know whether there are family members with neurological disorders. I ask specifically about migraine. I ask specifically about infertility issues. I ask specifically about psychiatric issues. These three things are always on the top of my mind when asking about family history. The other thing is a family history for neurodevelopmental disorder, because you know that some people might not remember that some genetic white matter diseases can present at different ages. So, in the same family, there might be cases with a pediatric-onset leukodystrophy, and that can manifest at a later age in other family members. So, this is something that we always explore. In terms of the clinical history, one question that I recommend always to ask is really about more subtle symptoms. So, for example, many of our patients present with progressive balance problems or progressive mobility issues that have been going on for a while. So, we always ask how they were when they were in their teenage years, for instance. And it's frequent that they say, actually, I was a bit clumsy. Actually, I was not the first being picked in school at phys-ed sports. And these are all interesting aspects. Maybe they are totally incidental, and sometimes they suggest that there was probably something going on for a long time. The other thing is the presence, for example, of learning difficulties. Again, these are things that are subtle but testify that there was probably a process that was more longstanding. Dr Monteith: You talked about things like rim lesions. Are there other types of sequences that might be useful to better characterize demyelinating diseases that are genetic in origin? I assume higher levels of MRI might be better at differentiating. Dr La Piana: Yeah. So, in the clinical setting, there are a couple of sequences that are very useful. One is the diffusion, because as opposed to multiple sclerosis, the presence of persistently restricted areas of diffusion can point immediately towards some genetic white matter diseases. One is CSF1R-related disorders. But there are also some other, more rare tremor and ataxia syndrome that present with persistent areas of restricted diffusion as well as others. The presence of calcification. So, adding an SWI, susceptibility weighted imaging, to check not just for calcifications that can immediately orient towards some disorders, but can also identify areas of microhemorrhages that, if we are going back to the leukovasculopathies, to the genetic leukovasculopathies, can tell us that we are on the right track for excluding those type of diseases. Basically, these are the two that are available in every scanner without even going into fancy, more advanced techniques. Dr Monteith: I was going to ask you that question, how often should we think about this next-generation sequencing when you're kind of on the fence, allowing for some negative results to come back in the abundance of caution? Dr La Piana: The problem with the panel, of course, is that you run a panel and you don't know what's coming back. So, then having to deal with variants of unknown significance in genes, then you have to deal with them, and then you have to deal with results that maybe are not as black or white as you would expect initially. So, I'll answer to your question when to do that, our recommendation would be to do that every time you are presented with a patient that presents those atypical features that we summarized in the paper, and that basically raise multiple red flags for an atypical white matter disease that is not multiple sclerosis. And then what to do when you have results? I still believe that having access, of course, to genetic counselors, to neurogeneticists, is critical, but also having access and being in contact with the network of people working on this. Because we are a network; we put the website address on the paper of the white matter rounds because this is an international network that we built over the years, and we connect monthly, on a monthly basis, with meetings to discuss exactly this type of patient. So, we are all learning together, and it's very frequent that people ask us to present cases at the white matter rounds because they have a presented with unusual or atypical genetic findings and they want the opinion of experts. Dr Monteith: Great. Well, I'm really glad that resource is available. And I'm also really glad that you wrote that article with your colleague. Thank you so much. Dr La Piana: Thank you so much, Tesha. Dr Monteith: Today I have been interviewing Dr Roberta La Piana about her article on adult-onset leukodystrophies mimicking multiple sclerosis, which she wrote with Dr Gabrielle Macaron. This article appears in the April 2026 Continuum issue on multiple sclerosis. Be sure to check out Continuum Audio episodes from this and other issues, and thank you to our listeners for joining today. Dr Monteith: This is Dr Teshamae Monteith, Associate Editor of Continuum Audio. If you've enjoyed this episode, you'll love the journal, which is full of in-depth and clinically relevant information important for neurology practitioners. Use the link in the episode notes to learn more and subscribe. AAN members, you can get CME for listening to this interview by completing the evaluation at continpub.com/audioCME. Thank you for listening to Continuum Audio.
In part two of this two-part episode of the Brain & Life podcast, host Dr. Daniel Correa is joined by influencer and podcaster Allie Signorelli. She shares her entrance into the world of advocacy and why she chose to speak up about her experiences and participate in research opportunities. Dr. Correa is then joined by Dr. Rodolfo Savica, who explains what some of those research opportunities are, why they matter, and what's next for the Parkinson's community. Additional Resources Allie Signorelli: Living With Young Onset Parkinson's What is Parkinson's Disease? Factors That May Increase the Risk of Parkinson's Disease Brain & Life Podcast Episodes on Similar Topics A Walk in the "Parkinson's" with Author Annmarie O'Connor Ed Begley Jr. on Utilizing a Healthy Lifestyle to Thrive with Parkinson's Disease How American Ninja Warrior Jimmy Choi Rose Above Parkinson's We want to hear from you! Have a question or want to hear a topic featured on the Brain & Life Podcast? · Record a voicemail at 612-928-6206 · Email us at BLpodcast@brainandlife.org Social Media Guests: Allie Signorelli @imstillallie; Dr. Rodolfo Savica @mayoclinic Hosts: Dr. Daniel Correa @neurodrcorrea; Dr. Katy Peters @KatyPetersMDPhD
Garth Heckman The David Alliance TDAgiantSlayer@Gmail.com Did you know that yesterday EASTER was the exact anniversary of our Lord and Saviors death. Exactly 1,993 years ago on that exact day Christ rose from the grave. Walking through the cemetery as a kid at night… We fear death.. Not birth Not life But death… we can't relate. I could claim to be born as a God I could claim to live as a God I could claim to die as a God But am I willing to CLAIM to resurrect 3 days later to prove it… But because he did resurrect we now no longer need to fear death. He conquered it, he made a fool of it, he said where is your sting oh death. Thats all you got? And why wait 3 days until you come back to life? 1. Ancient Medical Understanding: When is someone truly dead? In the ancient world (including Jewish and Greco-Roman thought), people didn't have modern tools to confirm death (no EEG, no heart monitors). So they relied on observable signs: What they looked for: * No breathing * No pulse (very hard to detect accurately) * Body cooling * **Onset of decomposition** The key issue: People could appear dead and revive (coma, shock, hypothermia) So there was always a lingering fear: “What if they weren't really dead?” 2. Why “Three Days” Became a Cultural Threshold** In Jewish thought, there was a widespread belief (not formal doctrine, but common teaching) that: The soul hovered near the body for about 3 days** After that: * The body began to visibly decay * The soul was considered fully departed * Death was **final and irreversible** You see this hinted at in the story of Lazarus: “Lord, by this time there is a stench, for he has been dead four days.” (John 11:39) That's not just a detail—it's a theological statement: “This is beyond recovery. This is real death.” 3. Modern Medical Insight: Decomposition Timeline Even today, decomposition supports why 3 days is significant: Within ~72 hours after death: Rigor mortis comes and goes Autolysis** (cells breaking down) accelerates Putrefaction begins (bacteria causing decay) Odor becomes noticeable By day 3, the body is unmistakably dead. So even by modern standards: Three days removes doubt. 4. The Power of the Resurrection Timing Jesus didn't rise immediately. That's critical. If He rose: * After a few hours → skeptics say “He fainted” * After one day → “Maybe He wasn't fully dead” But after three days: It destroys every natural explanation. This is why the resurrection isn't just miraculous—it's strategically undeniable. 5. Biblical Pattern: “Third Day” = Divine Intervention The “third day” shows up all over Scripture as the moment God acts decisively: * Hosea 6:2 — “On the third day He will raise us up” * Jonah 1:17 — Jonah in the fish 3 days * Genesis 22 — Abraham receives Isaac back (figuratively) on the third day The pattern: Day 1 = loss Day 2 = silence Day 3 = God moves Jesus steps into that pattern and fulfills it. 6. Roman Execution Certainty From a historical standpoint: * Roman crucifixion was brutally efficient * Executioners ensured death (piercing, blood loss, asphyxiation) * Bodies weren't casually misdiagnosed So combine: * Roman certainty of death * 3 days in the tomb * Sealed grave The resurrection claim becomes *maximally bold*. Bottom Line (Teaching Power Statement) Three days wasn't random. It was intentional. It ensured that: * No one could argue Jesus merely fainted * Death had fully taken its course * Resurrection could only be explained as supernatural “Jesus didn't come back early—He waited until death had fully won… and then He crushed it.”
The great lie of the Epstein scandal isn't just what he did, but how the powerful around him suddenly claimed they couldn't remember him at all. Presidents, princes, billionaires, academics, bankers, and celebrities who once courted his money and shared his jets all reached for the same script when the walls closed in: I barely knew him. It was a coordinated act of survival, not an accident. Institutions like Harvard, MIT, Deutsche Bank, and JP Morgan played the same game, pretending they never saw the red flags. Legacy media, instead of hammering the contradictions, often published these denials straight, allowing amnesia to masquerade as truth. Forgetting became strategy, and strategy became cover.But memory leaves evidence. Flight logs, photographs, donations, and testimonies remain, and every denial only underscores the complicity of those who looked away. The survivors don't get to forget; they live with scars while the powerful rewrite history. What the amnesia act reveals is cowardice: a willingness to erase reality to protect reputation. Epstein built his empire on memory, yet his circle tried to survive through erasure. In the end, their denials brand them more deeply than their associations ever could—because the attempt to forget is itself proof they remembered perfectly well.to contact me:bobbycapucci@protonmail.com
The great lie of the Epstein scandal isn't just what he did, but how the powerful around him suddenly claimed they couldn't remember him at all. Presidents, princes, billionaires, academics, bankers, and celebrities who once courted his money and shared his jets all reached for the same script when the walls closed in: I barely knew him. It was a coordinated act of survival, not an accident. Institutions like Harvard, MIT, Deutsche Bank, and JP Morgan played the same game, pretending they never saw the red flags. Legacy media, instead of hammering the contradictions, often published these denials straight, allowing amnesia to masquerade as truth. Forgetting became strategy, and strategy became cover.But memory leaves evidence. Flight logs, photographs, donations, and testimonies remain, and every denial only underscores the complicity of those who looked away. The survivors don't get to forget; they live with scars while the powerful rewrite history. What the amnesia act reveals is cowardice: a willingness to erase reality to protect reputation. Epstein built his empire on memory, yet his circle tried to survive through erasure. In the end, their denials brand them more deeply than their associations ever could—because the attempt to forget is itself proof they remembered perfectly well.to contact me:bobbycapucci@protonmail.com
Shane and Marty are joined by Tony Serrano, PING Principal Design Engineer, to review the new Scottsdale TEC putter line. They discuss the research behind Eye-Q, a new Scottsdale TEC alignment technology, PING’s philosophy as it applies to the Onset models, and the other multi-material mallets in the lineup. See omnystudio.com/listener for privacy information.
In part one of this two-part episode of the Brain & Life podcast, host Dr. Daniel Correa is joined by influencer and podcaster Allie Signorelli. She shares her experience living with young-onset Parkinson's disease, from noticing early symptoms to receiving a diagnosis at a time when she didn't see people her age represented in the Parkinson's conversation. Dr. Correa is then joined by Dr. Rodolfo Savica, who explains the importance of early diagnosis, non-motor symptoms, and environmental and genetic factors. Come back for part two next week to hear about Allie's entrance into the world of advocacy and upcoming research. Additional Resources Allie Signorelli: Living With Young Onset Parkinson's What is Parkinson's Disease? Factors That May Increase the Risk of Parkinson's Disease Brain & Life Podcast Episodes on Similar Topics A Walk in the "Parkinson's" with Author Annmarie O'Connor Ed Begley Jr. on Utilizing a Healthy Lifestyle to Thrive with Parkinson's Disease How American Ninja Warrior Jimmy Choi Rose Above Parkinson's We want to hear from you! Have a question or want to hear a topic featured on the Brain & Life Podcast? · Record a voicemail at 612-928-6206 · Email us at BLpodcast@brainandlife.org Social Media Guests: Allie Signorelli @imstillallie; Dr. Rodolfo Savica @mayoclinic Hosts: Dr. Daniel Correa @neurodrcorrea; Dr. Katy Peters @KatyPetersMDPhD
Join an expert-led discussion exploring the safety and clinical outcomes of Class 1c antiarrhythmic therapy following percutaneous coronary intervention (PCI) in patients with new-onset atrial fibrillation, based on insights from a nationwide cohort study. Deep Chandh Raja, MBBS, MD, PhD (Australian National University and Kauvery Hospital) hosts a dynamic conversation with Sandeep Gautam, MD, MPH, FHRS (University of Missouri Health) and Deepak Padmanabhan, MD, FHRS (Narayana Institute of Cardiac Sciences, Bengaluru). Together, they examine real-world data on the use of Class 1c agents in a traditionally high-risk population, addressing long-standing concerns about proarrhythmia and ischemic heart disease. The discussion will highlight patient selection, evolving clinical practice patterns, and implications for guideline-directed management, offering clinicians practical insights into optimizing rhythm control strategies in complex post-PCI patients. Learning Objectives Evaluate the safety profile and clinical outcomes associated with Class 1c antiarrhythmic therapy in patients with new-onset atrial fibrillation following PCI. Identify appropriate patient selection criteria and clinical considerations when prescribing Class 1c agents in the context of ischemic heart disease. Apply evidence from nationwide cohort data to inform decision-making and optimize rhythm management strategies in post-PCI atrial fibrillation patients. Link to the Article for Discussion Article AuthorsTing-Chun Huang MD, Po-Hsueh Su MD, Hui-Wen Lin MS, Po-Tseng Lee MD, Yu Liao MD, Chao-Yu Chen MD, Li-Hao Yap MD, Sheng-Hsiang Lin PhD, Yi-Heng Li MD, PhD Podcast ContributorsDeep Chandh Raja, MBBS, MD, PhD Sandeep Gautam, MD, MPH, FHRS Deepak Padmanabhan, MD, FHRS Host and Contributor Disclosure(s): D.C. RajaNothing to disclose. S. Gautam Honoraria/Teaching/Speaking/Consulting: Biosense Webster Fellowship Support: Medtronic Inc., Abbott D. Padmanabhan Nothing to disclose.
The great lie of the Epstein scandal isn't just what he did, but how the powerful around him suddenly claimed they couldn't remember him at all. Presidents, princes, billionaires, academics, bankers, and celebrities who once courted his money and shared his jets all reached for the same script when the walls closed in: I barely knew him. It was a coordinated act of survival, not an accident. Institutions like Harvard, MIT, Deutsche Bank, and JP Morgan played the same game, pretending they never saw the red flags. Legacy media, instead of hammering the contradictions, often published these denials straight, allowing amnesia to masquerade as truth. Forgetting became strategy, and strategy became cover.But memory leaves evidence. Flight logs, photographs, donations, and testimonies remain, and every denial only underscores the complicity of those who looked away. The survivors don't get to forget; they live with scars while the powerful rewrite history. What the amnesia act reveals is cowardice: a willingness to erase reality to protect reputation. Epstein built his empire on memory, yet his circle tried to survive through erasure. In the end, their denials brand them more deeply than their associations ever could—because the attempt to forget is itself proof they remembered perfectly well.to contact me:bobbycapucci@protonmail.comBecome a supporter of this podcast: https://www.spreaker.com/podcast/the-epstein-chronicles--5003294/support.
The great lie of the Epstein scandal isn't just what he did, but how the powerful around him suddenly claimed they couldn't remember him at all. Presidents, princes, billionaires, academics, bankers, and celebrities who once courted his money and shared his jets all reached for the same script when the walls closed in: I barely knew him. It was a coordinated act of survival, not an accident. Institutions like Harvard, MIT, Deutsche Bank, and JP Morgan played the same game, pretending they never saw the red flags. Legacy media, instead of hammering the contradictions, often published these denials straight, allowing amnesia to masquerade as truth. Forgetting became strategy, and strategy became cover.But memory leaves evidence. Flight logs, photographs, donations, and testimonies remain, and every denial only underscores the complicity of those who looked away. The survivors don't get to forget; they live with scars while the powerful rewrite history. What the amnesia act reveals is cowardice: a willingness to erase reality to protect reputation. Epstein built his empire on memory, yet his circle tried to survive through erasure. In the end, their denials brand them more deeply than their associations ever could—because the attempt to forget is itself proof they remembered perfectly well.to contact me:bobbycapucci@protonmail.comBecome a supporter of this podcast: https://www.spreaker.com/podcast/the-epstein-chronicles--5003294/support.
2. The economic fallout is highlighted by a 30% surge in gasoline prices, reaching $4.09 in Connecticut within only three weeks of the war's onset. Germanicus posits that if the "emperor"—who is reportedly distracted by "kill reels" of explosions—cannot stabilize the global supply chain, the military or Senate may be forced to intervene to prevent a total domestic collapse. This instability threatens to further impoverish European and Asian allies who are increasingly treated as subservient vassals. (2)1569 LONDINIUM
Cases of late-onset cerebellar ataxias are a challenge for neurologists. In this episode Dr. Orlando Barsottini and Dr. José Luiz Pedroso discuss new advances on the investigation of late-onset cerebellar ataxias and identification of new genes.
VetFolio - Veterinary Practice Management and Continuing Education Podcasts
Understanding the danger of acute pancreatitis in your canine patients is essential, as vague clinical signs can turn into a life-threatening, multi-organ crisis quickly. Acute pancreatitis is often overlooked in patients presenting with gastrointestinal (GI) signs. This episode of the VetFolio Voice podcast will help clinicians build suspicion for pancreatitis by recognizing key risk factors in dogs. We explore practical approaches to diagnosis, build confidence in initiating treatment, and highlight both supportive care and emerging therapeutics, such as Panoquell-CA1, to help you optimize outcomes.
In this episode, we delve into early age onset colorectal cancer, which is increasingly affecting individuals under 50. Join Dr. David Blumberg, a colorectal and general surgeon, as he discusses critical warning signs that should never be ignored. Don't miss expert insights on screening recommendations and preventive measures. Learn more and take action because early detection can save lives!
In this CE Podcast Judy, Dr. Sarah Capalla and Jenny Ballard discusses the impact of the impending CMS movement towards imposing Hospital Onset Bacteremia (HOB) reporting. The conversation discusses education, leadership, and the use of medical technologies to prevent vascular access harm.The learning objectives are:• Explain what Hospital-Onset Bacteremia and Fungemia (HOB) are• List the types of vascular access catheters, both venous and arterial, associated with Hospital-Acquired Infections (HAIs)• Discuss what cyanoacrylate tissue adhesive is and highlight the features that make it valuable for caring for and maintaining vascular access catheters• Review research findings and real-world examples showing cyanoacrylate tissue adhesive used with patients of all agesThis presentation will award the attendee with 1 contact hour of continuing education. The Association for Vascular Access is an accredited continuing education provider through the California Board of Registered Nurses. Provider #: CEP12371.This Podcast will be available 60 days and offers 1 CE until May 20, 2026.Listen to the end of the podcast for instructions on how to claim your CE. Support the show
Featuring an interview with Dr Ravin Ratan, including the following topics: Efficacy and safety of long-term continuous nirogacestat treatment in adults with desmoid tumors: Results from the Phase III DeFi trial (0:00) Onset and resolution of ovarian toxicity with nirogacestat treatment for desmoid tumors: Updated safety analyses from the DeFi trial (4:37) Subgroup analysis of the Phase II part of the RINGSIDE Phase II/III trial of varegacestat for desmoid tumors (7:39) Surgical management of desmoid tumors; cryotherapy in the treatment of extra-abdominal desmoid tumors (10:30) CME information and select publications
Was the food fraud intended to be a fraud from the onset? Do the engineers of the fraud go to the top of US politics? Tiffany Henyard the disgraced former mayor of Dalton Illinois, has shown up in GA running for office as a Republican. Six Bigfoot sighting outside of Cleveland. Johnny Heidt with guitar news. Heard On The Show:Man in crisis fatally shot by Rochester police after struggle with officers: RPDFormer assistant US attorney who told federal judge ‘this job sucks' now running for CongressIran's new supreme leader vows to keep blocking Strait of Hormuz in first statement released by regimeSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
The need to close any open doors. And the book Sudden Onset Headaches: https://happybooks.me/headaches
My guest today on the Online for Authors podcast is Kim Gottlieb-Walker, author of the book Lenswoman in Love. Kim Gottlieb-Walker's career as a photographer covered a wide range of subjects, from classic rock and roll, reggae, and politics in the ‘60s and ‘70s to major motion pictures and television shows. While still at UCLA (where she received a BA in Motion Picture production) and shortly thereafter, she shot for underground LA newspapers and magazines including Crawdaddy, the Staff, and Music World. She also shot the stills for John Carpenter's Halloween, The Fog, Christine and Escape from New York and worked at Paramount Pictures for nine years as the production photographer for Cheers, and five years for Family Ties. For three decades she was an elected representative for still photographers on the National Executive Board of IATSE Local 600, the International Cinematographers Guild. Her coffee-table photo books Bob Marley and the Golden Age of Reggae and On Set with John Carpenter were published by Titan Press (UK) distributed by Random House (USA) and both are now in multiple printing. They have editions in Japanese, Russian and French. She's had gallery shows in London, Los Angeles and New York. Her debut novel, LENSWOMAN IN LOVE - a novel of the 1960s & ‘70s has won over a dozen literary awards. Her not-yet published historical novel CATERINA BY MOONLIGHT, is about a girl growing up in Renaissance Florence in the late 15th century. Her short story “Summer of Love – 1967” appears in the multi-award-winning anthology FEISTY DEEDS. In my book review, I stated Lenswoman in Love is a historical romance by Kim Gottlieb-Walker. We are introduced to Maddy Garfield as a teenager at some point after her father dies. Her mother owns a bar where folk musicians play and hires a college kid working arely ifor a degree in film for the summer to help out. Maddy, known as Garfield to the new hire, Jake, falls madly and deeply in love. But the age different is too great, and Jake heads back to school early. Maddy never forgets him and spends her days comparing others to him. And they always come up short. In the meantime, she becomes a photographer and scrabbles her way up the ladder, slowly capturing stories and people - occasionally finding her way into Jake's circle. This story is filled to the brim with musical and film references, as well as the unrest of the 60s and 70s. Vietnam? It's in there. Nuclear plants? Yep. Bob Marley? The Beatles? Hippes? College protests? And so much more. These references land the book squarely in historical fiction, though it pains me that these decades are considered historical. However, Maddy's deep and abiding love for a man she barely knows puts the book into the romantic realm. And Kim balances the two with ease. I enjoyed the book thoroughly, and think you will, too! Subscribe to Online for Authors to learn about more great books! https://www.youtube.com/@onlineforauthors?sub_confirmation=1 Join the Novels N Latte Book Club community to discuss this and other books with like-minded readers: https://www.facebook.com/groups/3576519880426290 You can follow Author Kim Gottlieb-Walker Website: http://www.lenswoman.com/ Website: https://www.caterinabymoonlight.com/ FB: @KimGottliebWalker LinkedIn: @Lenswoman IG: @kimbgottliebwalker Purchase Lenswoman in Love on Amazon: Paperback: https://amzn.to/4qbwKWb Ebook: https://amzn.to/4k9mRGU Teri M Brown, Author and Podcast Host: https://www.terimbrown.com FB: @TeriMBrownAuthor IG: @terimbrown_author X: @terimbrown1 Want to be a guest on Online for Authors? Send Teri M Brown a message on PodMatch, here: https://www.podmatch.com/member/onlineforauthors #kimgottliebwalker #lenswomaninlove #historicalfiction #romance #terimbrownauthor #authorpodcast #onlineforauthors #characterdriven #researchjunkie #awardwinningauthor #podcasthost #podcast #readerpodcast #bookpodcast #writerpodcast #author #books #goodreads #bookclub #fiction #writer #bookreview *As an Amazon Associate I earn from qualifying purchases.
Get Tactacam Cameras for 15% off with code HA152026 - https://www.tactacam.com/Get 20% Off Pnuma Outdoors Gear here: https://pnumaoutdoors.com/?rfsn=8534842.ba528aUse code HNTA15 for 15% Off Out On A Limb MFG products: https://outonalimbmfg.com/ Use code HA10 for 10% VPA Broadheads: vparchery.com Check out Alberta Professional Outfitters Society for Hunting Alberta: https://www.apos.ab.ca/ Follow our socials: TikTok: https://www.tiktok.com/@huntersadvantage Instagram: https://www.instagram.com/hunters_advantage Facebook: https://www.facebook.com/Thehuntersadvantage Gmail: thehuntersadvantage@gmail.com
In this episode of Breaking the Rules, we explore when and why OCD tends to peak across the lifespan — and why symptoms often intensify during moments of growth, change, and meaning rather than out of nowhere.Drawing on clinical experience and developmental theory, this conversation looks at the predictable windows of vulnerability where OCD commonly emerges or flares: childhood and puberty, late adolescence and young adulthood, and major life transitions such as starting high school, exams, relationships, parenthood, grief, and identity shifts.Rather than focusing solely on symptoms, the discussion centres on formulation, psychoeducation, and normalisation — helping both clinicians and clients answer the critical question: why now?
Landis Wiedner shares her journey with adult-onset epilepsy after being diagnosed at the age of thirty-two. She describes how seizures impacted her life and work, explains how a stay in and epilepsy monitoring unit led to a life-changing medication change, and shares her experiences dating with epilepsy.
Innovating On-Set Communication: A Conversation with Onset Headsets Founder MattIn this episode of the Get Reelisms Podcast, hosts Adam Chase Rani and Christine Chen dive into a discussion with special guest Matt, founder of Onset Headsets. The conversation covers Matt's journey from working in film production as an Assistant Director (AD) to founding a company that innovates communication gear for filmmakers. Matt shares the story behind Onset Headsets, their product offerings, and the entrepreneurial challenges he faced. The podcast also highlights the critical role of customized, high-quality headsets for the film industry, Matt's unique solutions to common on-set problems, and upcoming plans for the company. Listeners can enjoy insights into film production nuances, hear about the camaraderie on film sets, and learn about Onset Headsets' innovative delivery service in Los Angeles. By the end of the podcast, Matt provides listeners with a special discount code for Onset Headsets products. Hosts: Adam Rani (@adamthechase) & Christine Chen (@cchenmtf) About Christine W Chen:Christine W. Chen is a Taiwanese American filmmaker, Academy member (Short Films Branch), and versatile producer, director, and writer known for bold, character-driven storytelling. Through her production company, Moth to Flame, she has created award-winning short films, features, and branded content—including Erzulie, a feminist swamp thriller that had a limited theatrical run and now streams on major platforms. In addition to her directorial work, Christine is a seasoned DGA 1st Assistant Director and co-author of Get Reelisms and ABCs of Filmmaking, as well as the co-host of the Get Reelisms Podcast.For more information about Christine Chen: christinewchen.com About Adam Rani:Adam Chase Rani is a production designer and set dresser working in the Austin film market, bringing a sharp eye for visual storytelling and practical creativity to every project. During the pandemic, he co-founded the Get Reelisms Podcast with Christine Chen to foster community within the film industry. Together, they've built a platform that blends education, candid conversations, and industry insights to help filmmakers connect, learn, and grow. For more information go to getreelisms.com For more information on ERZULIE go to: erzuliefilm.com WEBISODE version of the PodcastTIME SUMMARY:00:00 Introduction to the Role of an AD00:55 Welcome to the Get Reelisms Podcast01:31 Meet Matt from Onset Headsets02:58 The Birth of Onset Headsets05:16 Innovative Headset Solutions07:30 Challenges and Innovations in Filmmaking08:06 Onset Headsets Delivery Service10:45 Customization and User Feedback14:55 Partnerships and New Products20:52 Transition from AD to Entrepreneur24:03 Expanding Onset Headsets25:56 Tech Influence in Austin27:18 Upcoming Events for Onset Headsets29:08 Expanding Nationwide29:48 Innovations in Headset Technology30:44 Customer Experiences and Feedback38:20 Bulk Orders and Customization41:30 Durability and Warranty47:03 Exclusive Discount Code48:13 Conclusion and Housekeeping Official Get Reelisms PageGet Reelisms Amazon StoreInstagram
In this episode, we're discussing early Get Out vibes, asbestos awareness, Mulder's tailor and the FBI's only doctor. That's right, we're taking a deep dive into season four episode three, Teliko. If you'd like to feature in our next episode then tweet us @TheMSRFilesPod or send your emails to TheMSRFilesPodcast@GMail.com where you can also send in your own paranormal stories to feature in our next Do You Think I'm Spooky? Segment. Also, don't forget to check us out on Instagram and TikTok @TheMSRFilesPodcast
Singer-songwriter and Lyme disease advocate Jesse Ruben joins the Tick Boot Camp Podcast for an incredibly honest, emotional, and deeply educational conversation about chronic Lyme disease, identity loss, treatment failure, unconventional healing, relapse, nervous system trauma, and the role of music and community in survival. Jesse's journey spans more than a decade and includes misdiagnosis, years of antibiotic treatment, experimental therapies, remission, relapse during the pandemic, gut microbiome restoration, nervous system healing, and ultimately a renewed sense of purpose through advocacy and art. This episode is essential listening for anyone navigating chronic Lyme disease, supporting someone who is sick, or questioning whether healing is still possible. Jesse Ruben's Early Life and Music Career Jesse grew up outside Philadelphia, surrounded by music, creativity, and curiosity. While he jokes that his songwriting degree was “a very expensive, useless piece of paper,” the competitive creative environment of music school helped sharpen his storytelling voice. By his early 20s, Jesse was living in New York City, touring, running marathons, and building momentum as an independent musician. He had just completed his third New York City Marathon, was in peak physical condition, and his career was accelerating—until his health began to unravel. The Onset of Illness: When Lyme Disease Took Everything Jesse's first red flag appeared when he became short of breath climbing subway stairs, despite being a marathon runner. Soon after, nausea, dizziness, headaches, neurological symptoms, and crushing fatigue followed. On Christmas Day 2012, Jesse developed what seemed like a flu that never went away. Over the following months, symptoms escalated dramatically: Severe fatigue that made basic movement impossible Brain fog and memory loss Crawling sensations under the skin Air hunger and dizziness Anxiety, depression, and mood changes Weight loss and neurological dysfunction Despite seeing 15 doctors over nine months, Jesse received conflicting diagnoses ranging from vitamin deficiencies to fibromyalgia and lupus. Every test came back “normal.” Insurance denied coverage. Doctors told him he would “have to live with it.” During a national tour, Jesse was so debilitated that a friend physically lifted him onto the stage to perform, then carried him back to the van afterward. Eventually, through relentless self-research, Jesse discovered a symptom list online that finally connected the dots: Lyme disease. Diagnosis and Early Treatment Failure Jesse was ultimately diagnosed at the Morrison Center in New York City, where testing confirmed: Lyme disease Babesia Mycoplasma His initial treatment path included: 6 months of oral doxycycline 18 months of IV azithromycin Antiparasitics Mepron (for Babesia) Antifungals, antivirals, supplements, and Chinese herbs Despite years of treatment, nothing produced lasting improvement. Jesse describes his life during this period as being reduced to pill schedules, doctor visits, and survival mode. The Game Changer: Chelation and Ozone Therapy After nearly three years with minimal progress, Jesse's provider, Dr. Gerald (“Jerry”) T. Simons at the Morrison Center, suggested a more experimental approach: chelation combined with ozone therapy. Jesse underwent IV chelation and ozone therapy multiple times per week for several months. The results were dramatic. Nearly all of Jesse's symptoms resolved, and for the first time, he felt like himself again. Even years later, booster ozone treatments helped stop symptom flares before they escalated.
The great lie of the Epstein scandal isn't just what he did, but how the powerful around him suddenly claimed they couldn't remember him at all. Presidents, princes, billionaires, academics, bankers, and celebrities who once courted his money and shared his jets all reached for the same script when the walls closed in: I barely knew him. It was a coordinated act of survival, not an accident. Institutions like Harvard, MIT, Deutsche Bank, and JP Morgan played the same game, pretending they never saw the red flags. Legacy media, instead of hammering the contradictions, often published these denials straight, allowing amnesia to masquerade as truth. Forgetting became strategy, and strategy became cover.But memory leaves evidence. Flight logs, photographs, donations, and testimonies remain, and every denial only underscores the complicity of those who looked away. The survivors don't get to forget; they live with scars while the powerful rewrite history. What the amnesia act reveals is cowardice: a willingness to erase reality to protect reputation. Epstein built his empire on memory, yet his circle tried to survive through erasure. In the end, their denials brand them more deeply than their associations ever could—because the attempt to forget is itself proof they remembered perfectly well.to contact me:bobbycapucci@protonmail.com
THE COLD WAR SHIFT: GEORGE KENNAN'S STRATEGIC PIVOT Colleague Professor Gary J. Bass. By 1948, the trial's context shifted dramatically with the onset of the Cold War and the Chinese Civil War. George Kennan, the architect of containment, visited Tokyo to convince MacArthur that democratization was less important than establishing Japan as a strong anti-communist bulwark against the Soviets. Kennan argued that the US must secure Japan as a strategic prize rather than focus on China, which was falling to Mao. This "reverse course" prioritized stability and industrial strength over the initial progressive reforms, viewing Japan as the essential anchor for Americanforeign policy in the Pacific. NUMBER 51929 TOKYO
Join as we revisit some of our favorite scenes about working in The Biz!Subscribe at patreon.com/mandog to get new episodes every week plus access to our HUGE backlog of episodes.3:30 - Writer's Room Weirdo w/ Madeline Walter and Paul Welsh11:37 - On Set w/ Cameron Kelly and Stephanie Burchinow19:42 - Devito Method w/ May Darmon and Rob Scerbo30:00 - Test Screening w/ Matt Apodaca and Conner McCabe37:34 - Big Tech Commercial Audition w/ Brian Huskey and Seth Morris43:36 - State Farm Commercial Pitch w/ Steindor Jonsson and Trevor Silverstein53:33 - Crichton Pitches w/ Shaun Diston and Devin Field1:01:57 - Actor Tries New Voices w/ Mike Castle and Marques Ray1:06:54 - Voice Acting 101 w/ Nick Wiger and Mike Mitchell1:16:26 - Let's Go Again w/ Lisa Gilroy and Druv Uday SinghSubscribe to ManDog on YouTube!Check out BigGrandeWebsite.com! Subscribe to Big Grande on Youtube! Eat Pray Dunk and Hey Randy on CBB World!
THE UNRAVELING OF THE STRONG MARRIAGE Colleague Barbara Weisberg. Weisberg details the unraveling of the Strong marriage as Mary grows restless at the Waverly estate. Amidst the onset of the Civil War, Mary begins an affair with Peter's brother, Edward, who is grieving his own wife. The segment ends tragically with the death of Mary's young daughter. NUMBER 6
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