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Vic the Brick haiku; The Wonderlick and weird questions at the NFL Combine will be no more. Chargers running back Justin Jackson hops on as they prepare to face the Raiders with a playoff berth on the line.
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.10.14.339671v1?rss=1 Authors: Morrison, A. J., Wonderlick, D. R., Harms, M. J. Abstract: Non-additivity between mutations--epistasis--profoundly shapes evolution. It can be difficult to understand its mechanistic origins. Here we show that "ensemble epistasis" is likely a universal feature of macromolecules. Using a simple analytical model, we found that epistasis arises when two conditions are met: 1) a macromolecule populates at least three structures and 2) mutations have differential effects on a least two of the inactive structures. To explore the relative magnitude of ensemble epistasis, we performed a virtual deep-mutational scan of the allosteric Ca2+ signaling protein S100A4. We found that 27% of mutation pairs gave ensemble epistasis with a magnitude on the order of thermal fluctuations, 1 kT. We observed many forms of epistasis: magnitude, sign, and reciprocal sign epistasis. Depending on the effector concentration, the same mutation pair could even exhibit different forms of epistasis. The ubiquity of ensembles in biology and its pervasiveness in our dataset suggests that ensemble epistasis may be a universal mechanism of epistasis. Copy rights belong to original authors. Visit the link for more info
Jeffy Mac's take on "The Last Dance" Perspective is being formed for younger generation that do not remember the 90s BULLS! NFL Draft Week! Validity of Wonderlick? Who you got if you need a QB? START/BENCH/CUT: From new IND/NE unis to TEBOW/RG3/Johnny Football #TuesdayGRIND www.THEGRINDONSPORTS.com
One of Triv's first of several interviews with Henry Hill who's life story was portrayed by Ray Liotta in the 1990 classic film "Goodfellas". Also an interview with 2003 World Series of Poker Champion Chris Moneymaker about the Poker boom in the early 2000's. Finally, listen and laugh as Triv takes the infamous NFL Wonderlick Test!
In Episode 38 Mason learns what daylight savings is, we debate hamster wheels for kids, and form the most fun mob ever to support chill legislation. Also, we get all millennial and do a March Madness style emoji bracket to determine the greatest emoji of all time. It's an upset. But it feels right. Then we get REALLY BUSINESS LIKE, with new segments "What Would You Say You Do Here" and "The Work Speak Translator." And we cover some of the weirdest questions from the NFL combine and make everyone take a Wonderlick test. Spoiler alert: we're stupid. Double spoiler: we're very fun though.
Happy Figgin’ A Friday!!!! Today We Gave Away Beer To a Bunch Of Rebellious Kids!! Talked About How Gimpy Rode His Bike Yesterday – But Not Today, Corbin Is Afraid Of The Wind, More #MOISTING, Corbin’s ‘Caucasian Issue’, “EFFING BIRDS!”, Flip Bangin’, Baker Mayfield’s ‘Wonderlick’, How Everyone Rebelled Against Their Parents – Corbin Just Didn’t At All And Gimpy Was A Ganbanger, Craigslist Took Down Their Personals, Gimpy Is Gonna Run A 5K In The Grass, Willy Nilly, The Struggle Is Wheel!!!!!! How Exactly Do You Gangbang Anyway?????? (Asking For A Friend……)
Happy Figgin’ A Friday!!!! Today We Gave Away Beer To a Bunch Of Rebellious Kids!! Talked About How Gimpy Rode His Bike Yesterday – But Not Today, Corbin Is Afraid Of The Wind, More #MOISTING, Corbin’s ‘Caucasian Issue’, “EFFING BIRDS!”, Flip Bangin’, Baker Mayfield’s ‘Wonderlick’, How Everyone Rebelled Against Their Parents – Corbin Just Didn’t At All And Gimpy Was A Ganbanger, Craigslist Took Down Their Personals, Gimpy Is Gonna Run A 5K In The Grass, Willy Nilly, The Struggle Is Wheel!!!!!! How Exactly Do You Gangbang Anyway?????? (Asking For A Friend……)
Tim describes himself as not a singer, but a writer with a band, and he shouted at the front of Too Much Joy in the late' 80s–'90s and has since recorded as Wonderlick while working as a big dog in the digital music industry with Google, Rhapsody, and now Freeform. We discuss "King of Beers" from Cereal Killers (1991), "Donner Lake" from Wonderlick (2002), "Just Like a Man" from Mutiny (1992), and also listen to "Extraordinary People" from Wonderlick's Super (2015). Read Tim's words at tbquirk.com, and toomuchjoy.com. Please spread the word about the podcast! You can also support our efforts. Musicians, tell us your song stories on video. Hear more Nakedly Examined Music.
Tim describes himself as not a singer, but a writer with a band, and he shouted at the front of Too Much Joy in the late' 80s–'90s and has since recorded as Wonderlick while working as a big dog in the digital music industry with Google, Rhapsody, and now Freeform. We discuss "King of Beers" from Cereal Killers (1991), "Donner Lake" from Wonderlick (2002), "Just Like a Man" from Mutiny (1992), and also listen to "Extraordinary People" from Wonderlick's Super (2015). Read Tim's words at tbquirk.com, and toomuchjoy.com. Please spread the word about the podcast! You can also support our efforts. Musicians, tell us your song stories on video. Hear more Nakedly Examined Music.
Now, here’s a strange name for a very important test! Every year at the NFL Combine, draft prospects learn that there’s nothing wonderful about taking the Wonderlick test - that mandatory and daunting eaxm with a funny sounding & highly intimidating name. That’s because potential NFL players can’t possibly prepare for the Wonderlic’s 12 minute, 50 multiple choice questions. Similar to college SAT exams, the Wonderlic test focuses on math, vocabulary and cognitive reasoning skills….and, ironically, poses no questions having anything whatsoever to do with football. MIKE on sports, sports humor, American sports culture, fun sports facts, sports history, sports stuff you should know, NFL
Singer-songwriter, digital musical impresario, and self-described "corporate motherfucker" Tim Quirk braves Los Angeles traffic to stop by and extol the virtues of both attention-based economy and passive-aggressive public relations. Johnny Dam joins us again, this time to inaugurate the new studio. And Rob's recent venture into cautious optimism seems to be paying off, if recent setbacks for Rupert Murdoch and The Black-eyed Peas are any indication. Music by The Donnas, The Benjamins, and Wonderlick.
Aaron, Josh, and John talk about the NFL lockout, Donovan McNabb, Keels, the Wonderlick, Dan Snyder and much, much, more!