Alteration in the nucleotide sequence of a genome
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A rogue strain of flu, subclade K, has sickened more than 19 million people in the US so far this season. And the flu shot hasn't offered that much protection. What's going on with this superflustorm?Joining Host Flora Lichtman with some answers is Jennifer Duchon, a pediatric infectious disease specialist.Guest: Dr. Jennifer Duchon is a pediatric infectious disease specialist at Mount Sinai Hospital in New York.Transcripts for each episode are available within 1-3 days at sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.
Sean Carroll's Mindscape: Science, Society, Philosophy, Culture, Arts, and Ideas
Evolution with natural selection involves an intricate mix of the random and the driven. Mutations are essentially random, while selection pressures work to prefer certain outcomes over others. There is tremendous divergence of species over time, but also repeated convergence to forms and mechanisms that are unmistakably useful. We see this clearly in eyes and fins, but the basic pattern also holds for brains and forms of social organization. I talk with philosopher Rachell Powell about what these ideas mean for humans, other terrestrial species, and also for forms of life we have not yet encountered.Blog post with transcript: https://www.preposterousuniverse.com/podcast/2026/01/26/342-rachell-powell-on-evolutionary-convergence-morality-and-mind/Support Mindscape on Patreon.Rachell Powell received her Ph.D. in philosophy from Duke University. She is currently a Professor of Philosophy at Boston University. She has held fellowships at the National Humanities Center, the American Council of Learned Societies, the Konrad Lorenz Institute for Evolution and Cognition Research, the National Evolutionary Synthesis Center, the Berlin School of Mind and Brain at Humboldt University, and the Center for Genetic Engineering and Society at North Carolina State University.Boston University web pagePhilPapers publicationsSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
For years I meditated on returning my body to its original blueprint. Then I realized — that blueprint was corrupted by inherited trauma.So I updated the meditation:Instead of healing back to baseline, I'm mutating my DNA toward the truest resonance of love my body can be, hold, and become.It's already cooperating.I'm reversing astigmatism. Healing autoimmune patterns. Becoming mushroom, seaweed, and beet. (Literally eating things I swore I hated.)But beyond healing — which frankly, I find dull and tedious at this point — I'm interested in mutation.What could I become if I were beyond needing to repair?I recorded a meditation for anyone ready to shift from maintenance mode to evolution mode.Your cells are listening. Your DNA is responsive. The mutation is already underway.Trust the becoming.✨ Explore more:@arielgracefull
durée : 00:04:27 - Le Grand reportage de France Inter - A Poissy, en région parisienne, le monde ouvrier des usines laisse peu à peu place aux immeubles neufs et peut-être même bientôt, au futur stade du PSG. Le club lorgne sur les 123 hectares du site de Stellantis, qui produit l'Opel Moka, mais seulement jusqu'en 2028. Vous aimez ce podcast ? Pour écouter tous les autres épisodes sans limite, rendez-vous sur Radio France.
Hier zum Video Jeder Human Design Typ zeichnet sich durch ganz bestimmte Fähigkeiten, Wahrnehmungspotenziale und damit verbundene Aufgaben aus. Kein Typ kann des Job eines anderen Typen übernehmen. Das gilt für veränderungsintensive Jahr wie das Übergangsjahr 2026 ganz besonders. Denn abhängig davon, welcher Typ Du bist, ist schon die Art und Weise, mit Wandel und Instabilität umzugehen ganz unterschiedlich ausgeprägt. Vielleicht wunderst Du Dich manchmal, warum manche Menschen ganz einfach Neuerungen in ihr Leben integrieren können, während andere dafür mehr Zeit brauchen und manche sie am liebsten ganz vermeiden würden. Vielleicht fragst Du Dich, wohin es für Dich in 2026 und darüber hinaus gehen wird oder welche konkreten nächsten Schritte jetzt für Dich anstehen. Dann ist diese Podcastfolge für Dich. Die Energie der Typen hängt von den definierten Zentren ab - und dabei spielt das Sakral-Zentrum die wichtigste Rolle, denn seine Definition prägt die sakrale Welt - den Typus den Generators und des MGs. Diese Menschen sind ja die Erbauer und dafür zuständig auch die neue Welt zu erschaffen. Interessanterweise: das Sakral-Zentrum ist, aufgrund seiner Torqualitäten aber gar nicht dafür bekannt, sehr flexibel und veränderungsbereit zu sein. Nur 2 Tore aus dem individuellen Schaltkreis des Wissens treiben die Mutation voran. Fast alle anderen sind aus Schaltkreisen - dem Kollektiv und dem Stamm - die eher das Vertraute lieben und sich nicht leicht und gerne auf ganz Neues einlassen. In dieser Folge gehen wir erst dem Sakral-Zentrum und dann den Typen mit ihrer ganz spezifischen Ausrichtung auf den Grund. Du erfährst, warum Generatoren und MGs sich klassischerweise etwas schwerer tun mit Veränderungen, während Projektoren, Manifestoren und Reflektoren geradezu darin aufblühen können. Auch gehe ich darauf ein, welche Rolle jeder einzelne Typ im Veränderungsprozess 2026 hat, worauf Du achten darfst und was Du besser vermeiden solltest. Ich wünsche Dir viele gute Erkenntnisse und hoffe, Du kannst viel mitnehmen. Wenn Du Lust hast, mit mir und meinem Team auf Human Design Reise zu gehen, meld Dich jetzt zum nächsten Living Your Design Kurs an. Wir starten am 23.1.2026. Human Design Academy Barbara Peddinghaus & Team Human Design Analytikerin und Lehrerin (IHDS) Hochstrasse 48 60313 Frankfurt Insta: www.instagram.com/humandesign_academy/
Today we'll be talking about flu mutations spiking thailand cases, a whole gaggle of foreigners behaving badly, and in feel-good Friday news we have Thai students winning the top prize in a snow sculpting contest in China.
We were joined by Kashena Sampson to discuss her newest album "Ghost of Me" and then we dive into "Mutations" from Beck (released in 1998). Plenty of other discussion like "this was his 6th album?," God stuff, breakups, alternative music in 1998 (we think the Grammy voters got it right), T.S. Eliot, The Beatles, viagra, rotten eggs and saloon piano. Check out Kashena Sampson at: https://www.kashenasampsonmusic.com/ Check out other episodes at RecordsRevisitedPodcast.com, Apple Podcasts, Castbox, iHeartMedia, Google Podcasts and Spotify. Additional content is found at: Facebook.com/recordsrevisitedpodcast or twitter @podcastrecords or IG at instagram.com/recordsrevisitedpodcast/ or join our Patreon at patreon.com/RecordsRevisitedPodcast
While the origins debate is basically a religious debate, many people have been taught that evolution is science and creation is religion. But even according to the evolutionists' own rules of science, evolution is not good science. Let's examine the claims of evolution in light of what science knows today.Life has never been seen to develop from nonliving materials. Yet evolution says it did. Mutations, said by evolutionists to have created all the kinds of living things, have never been seen to produce one creature who was more complex or better able to survive. Then again, the moon has moonquakes, a magnetic field and internal heat—all indications that it is far younger than evolutionists believe. The Cretaceous limestone was produced from sediment in water and extends in one continuous band from Northern Ireland through Europe and Asia to Australia. This suggests that the entire area was beneath the sea all at the same time, yet evolution refuses to accept Noah's Flood as a global and historical event.If language evolved, why are the most ancient languages the most complex? If religion evolved, why do the most ancient forms of religion worship one God, a Creator, while later forms of the same religions have many gods—who are much more like human beings?I could list many more examples showing that only the Bible's account of history makes sense in light of what we know today.Psalms 111:10"The fear of the LORD is the beginning of wisdom; A good understanding have all those who do His commandments. His praise endures forever."Prayer: Dear Lord; the very stones cry out that You are indeed Creator and Almighty God. Help me to add my voice to this witness, and tell others of Your forgiving love in Jesus Christ. In His Name. AmenREF.: Brown, Walter T. The scientific case for creation: 116 categories of evidence. Bible Science Newsletter. To support this ministry financially, visit: https://www.oneplace.com/donate/1232/29?v=20251111
In this episode, Hali and I are covering the January transits and sharing why this is our last monthly transit episode. We dive into why January 1st isn't the energetic new year (the Human Design new year starts January 22nd), what the Quarter of Mutation means for how you should actually be using this month, and why New Year's resolutions often fail.Plus, we explore the January transits and feature this week's Incarnation Cross - the Left Angle Cross of Distraction (2).Tired of fighting your own energy? Your Human Design for Energetic Clarity guidebook translates your Human Design into practical wisdom so you can stop forcing what doesn't work and start living what does. Grab yours here:https://www.humandesignhive.com/guidebookIncarnation Cross Unlocked Workshop (Replay)If you've ever looked up your Cross name and thought, “Okay, but what does that really mean for me?” — this workshop is going to make it click.https://www.humandesignhive.com/icx-workshopWant insight on your design, on your time? Check out the customized Audio Human Design Reading: https://www.humandesignhive.com/audio_readingGrab your FREE copy of your Human Design chart (Bodygraph) Here: https://www.humandesignhive.com/freechartFollow Dana on IG: Instagram (@humandesignhive)Website: https://www.humandesignhive.comemail: Dana@humandesignhive.comIn This Episode:Why we're ending monthly transit episodesThe truth about January energy and New Year's resolutionsHow the Quarter of Mutation supports reflection over actionWhen the actual Human Design new year beginsThis week's Incarnation Cross: Left Angle Cross of Distraction (2)Connect With Us: Subscribe to never miss an episode and get on our email list to stay updated on what's coming next for Human Design Hive. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit danaphillips.substack.com/subscribe
À l'aube d'une nouvelle année, Les Sens de la Danse propose un temps de pause.Un temps pour réfléchir à ce qui nous relie. À ce qui nous élève. À ce qui, par les temps qui courent, reste essentiel.Dans cet épisode voix seule, il est question de mouvement comme langage premier, de danse comme geste ancien, collectif, presque rituel.Un geste qui traverse les âges, accompagne les passages et continue d'exister quand tout se durcit.Sans analyse, sans témoignage, ce texte explore ce que la danse permet encore aujourd'hui : rester ouvert, maintenir du lien, préserver un espace de liberté et de vivant.Un épisode de fin d'année,comme un vœu discret adressé au corps, au mouvement, au commun.Si cet épisode vous touche, n'hésitez pas à vous abonner à Les Sens de la Danse et à soutenir le podcast.Très belles fêtes de fin d'année et rendez-vous dimanche prochain pour ouvrir ensemble une nouvelle saison.Je vous souhaite une très s belle écoute,Hébergé par Ausha. Visitez ausha.co/politique-de-confidentialite pour plus d'informations.
À l'approche de la fin de l'année, Les Sens de la Danse fait une pause. Un temps pour relier. Un temps pour remercier. Un temps pour écouter ce qui reste.Cet épisode n'est ni un bilan, ni un best-of. C'est un moment, un geste de reconnaissance pour toutes celles et ceux qui ont accepté de partager leur parcours, leur regard, leur rapport au mouvement au fil de l'année 2025.Merci à France Schott Billmann, Svetlana Panova, Aurélien Lehmann, Sofiane Chalal, Jemi Van Dijk, Veronica Christiny, Nelson Ewandé, Queensy, Cédric Andrieux, Yann Antonio, Andrea Sarri, Aurélia Monaco, Claire Francisci-Ducret, Bruce Ykanji, Aurélie Lili Boo, Karl Paquette, Fabienne Haustant, et Ruben Molina.Autant de voix singulières. Autant de manières d'habiter le corps, la danse, le monde.Si certains épisodes vous ont marqué, si d'autres vous ont échappé, c'est peut-être le moment de les (ré)écouter, de vous laisser traverser à nouveau par ces récits, ces gestes, ces élans.Et si Les Sens de la Danse résonne pour vous, n'hésitez pas à vous abonner au podcast pour continuer à explorer, ensemble, le pouvoir du mouvement.Un épisode pour fermer l'année en douceur, et laisser résonner les Sens de la danse.Hébergé par Ausha. Visitez ausha.co/politique-de-confidentialite pour plus d'informations.
In this episode, Jeremy offers an inspired monologue on recent discussions concerning whether one should be "against the machine," that is, against progress. "We can't just be against the worldview of progress," Jeremy wrote on a recent Mutations post. Rather, we ought to "stand firmly from another position, articulate another worldview."Technology shouldn't be ceded to the technologist, anymore than spirituality should be ceded to the reactionary right.What is needed is to respond to technoculture from a position of depth. The machine of progress needs to be met and exceeded with another, weirder temporality.It is precisely through embracing this weirder time that techno-culture has a chance to be subverted, and technology's more radical and emancipatory aspects might be potentiated.***Mutations is pleased to announce the launch of our first 2026 course offering: "Seeing Through the World: Jean Gebser and Integral Consciousness" starts on January 28th and runs for five consecutive weeks. We will be taking an in-depth look at many of themes explored in this episode. Scholarships are available! We hope to see you in class.Support Mutations on SubstackMutations on Patreon
durée : 00:59:04 - Le Book Club - par : Marie Richeux - Dans son dernier ouvrage, le poète Jérôme Game confronte vingt ans de pratique poétique aux arts plastiques et sonores. Christophe Manon, dans ses "Élégies mineures" déploie, quant à lui, une poésie sans images, d'un lyrisme tout en retenue. - réalisation : Vivien Demeyère - invités : Jérôme Game poète et écrivain; Christophe Manon Poète
Cancer treatment is moving toward a more precision-based approach, where therapies are guided not just by the tumor's location but also by its genetic features. Mutations in cancer cells can point to specific drugs that may be more effective for certain patients. However, detecting these mutations often requires broad and detailed analysis. This is where comprehensive genomic profiling becomes especially important. One of the main challenges in cancer care is that many existing genetic tools focus on only a limited number of mutations. As a result, some treatment opportunities may be missed. Certain mutations are also difficult to detect because they occur at low levels or exist in complex forms, such as gene fusions. Without advanced screening methods, these changes may go unnoticed. To address these challenges, researchers from Exact Sciences Corporation conducted a large-scale study using a broad genomic screening approach. The findings were recently published in the journal Oncotarget. Full blog - https://www.oncotarget.org/2025/12/15/comprehensive-genomic-profiling-in-cancer-insights-from-over-10000-tumors/ Paper DOI - https://doi.org/10.18632/oncotarget.28757 Correspondence to - Jean-Paul De La O - jdelao@exactsciences.com Abstract video - https://www.youtube.com/watch?v=awiRhDfiMTE Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28757 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, solid tumors, comprehensive genomic profiling, matched therapy, gene fusions, limit of detection To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM
Channel of Mutation ends and Sunita turns back into a pumpkin. This reference is relevant for the episode.
Superpowers make great fiction, but evolution doesn't work that way. We explore why mutations can't give us instant abilities—and what real science could create instead.Grab one of our new SFIA mugs and make your morning coffee a little more futuristic — available now on our Fourthwall store! https://isaac-arthur-shop.fourthwall.com/Visit our Website: http://www.isaacarthur.netJoin Nebula: https://go.nebula.tv/isaacarthurSupport us on Patreon: https://www.patreon.com/IsaacArthurSupport us on Subscribestar: https://www.subscribestar.com/isaac-arthurFacebook Group: https://www.facebook.com/groups/1583992725237264/Reddit: https://www.reddit.com/r/IsaacArthur/Twitter: https://twitter.com/Isaac_A_Arthur on Twitter and RT our future content.SFIA Discord Server: https://discord.gg/53GAShECredits:The Myth of Mutation Why Superpowers Don't Evolve (and What Might)Written, Produced & Narrated by: Isaac ArthurEditors: Lukas KonecnySelect imagery/video supplied by Getty ImagesMusic by Epidemic Sound: http://nebula.tv/epidemicChapters0:00 Intro3:05 How Stars Work: A Brief Guide9:44 The Main Sequence Stars, A Through M11:12 A-Type Stars12:00 F-Type Stars13:00 G-Type Stars14:12 K-Type Stars15:06 M-Type Stars16:55 Brown Dwarfs18:15 Red Giants21:00 Dead StarsSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Superpowers make great fiction, but evolution doesn't work that way. We explore why mutations can't give us instant abilities—and what real science could create instead.Grab one of our new SFIA mugs and make your morning coffee a little more futuristic — available now on our Fourthwall store! https://isaac-arthur-shop.fourthwall.com/Visit our Website: http://www.isaacarthur.netJoin Nebula: https://go.nebula.tv/isaacarthurSupport us on Patreon: https://www.patreon.com/IsaacArthurSupport us on Subscribestar: https://www.subscribestar.com/isaac-arthurFacebook Group: https://www.facebook.com/groups/1583992725237264/Reddit: https://www.reddit.com/r/IsaacArthur/Twitter: https://twitter.com/Isaac_A_Arthur on Twitter and RT our future content.SFIA Discord Server: https://discord.gg/53GAShECredits:The Myth of Mutation Why Superpowers Don't Evolve (and What Might)Written, Produced & Narrated by: Isaac ArthurEditors: Lukas KonecnySelect imagery/video supplied by Getty ImagesMusic by Epidemic Sound: http://nebula.tv/epidemicChapters0:00 Intro3:05 How Stars Work: A Brief Guide9:44 The Main Sequence Stars, A Through M11:12 A-Type Stars12:00 F-Type Stars13:00 G-Type Stars14:12 K-Type Stars15:06 M-Type Stars16:55 Brown Dwarfs18:15 Red Giants21:00 Dead StarsSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
In today's episode, we had the pleasure of speaking with Catherine Shu, MD, about the use of tepotinib (Tepmetko) in patients with non–small cell lung cancer harboring MET exon 14 skipping mutations. Dr Shu is the Price Family Associate Professor of Medicine and the clinical director of the Thoracic Medical Oncology Service at the Columbia University Herbert Irving Comprehensive Cancer Center in New York, New York. In our exclusive interview, Dr Shu discussed updated data from the phase 2 VISION trial (NCT02864992) that investigated tepotinib in this population, the notable efficacy of this agent in treatment-naive patients, and considerations for managing and mitigating the adverse effects associated with this therapy.
Le Vinyle revient en force cette année avec une émission toute de vert vêtue !! Après 2 étés bratesques à souhait et une annonce d'un nouvel album imminent de la part de Charli XCX (intitulé "Wuthering Heights" et qui se trouve être la bande originale de la version des Hauts de Hurlevent d'Emerald Fennell), la question de l'image et des références et inspirations cinéma semblait essentielle. Elle-même descendant directement de Gregg Araki dans la famille des Brat, mais nous nous prêterons aussi à une analyse de son compte Letterboxd, des réfs à Harmony Korine (Spring Breakers) ou à Lolita Malgré Moi (Mean Girls), des compositions pour le Bottoms d'Emma Seligman ou le Barbie de Greta Gerwig, .... En espérant que cela vous plaise et que l'épisode devienne, peut-être un club classics.... Et vous retrouverez ici le lien vers la playlist musicale de l'émission !épisode écrit et présenté par Enora Quéau
Munition in Nord- und Ostsee; Influenza - Droht eine schwere Grippe-Saison?; Lachgas - ist das ungesund?; Long Covid - Pandemie nach der Pandemie; Zeitenwende - auch im All?; Hauskatzen kamen erst mit Römern zu uns; Ein Monat Völlerei - kann der Körper das ab?; Moderation: Johannes Döbbelt. Von WDR 5.
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You may know Steven from his days being a co-host of Chasing Labels, but he has built a strong brand as a film discussion leader and physical media expert over the last 10 years.https://www.youtube.com/@Chasing_Labels
Humangenetiker wollen aus einer Blutprobe Hitlers DNA entschlüsselt und eine seltene Mutation bei ihm nachgewiesen haben: das Kallmann-Syndrom. Doch wie glaubwürdig ist das? Martin Gramlich im Gespräch mit Prof. Christian Schaaf, Ärztlicher Direktor am Institut für Humangenetik des Universitätsklinikums Heidelberg
I got your next X-Men movie right here!
Mutations podcast returns in this short, off-the-cuff episode as Jeremy offers an update on the manuscript (spoiler alert: it is now complete!), introduces a new online class happening in December, and gives listeners a rough sketch of where the show is headed next."Integral Futuring: Reclaiming Time in the Radical Present" is a three-day weekend seminar, beginning on December 5th. One might describe it as a riff on reclaiming the future, planetary thinking, and the need for a new temporality beyond the clock. Presentations are followed by breakout discussions, resource sharing, and Q&A. Join a community of fellow seekers and explorers for a weekend of in-depth conversations and fellowship.Please reach out if you might need a student discount/pay-what-you-can link. No one will be turned away.
durée : 02:31:38 - Les Nuits de France Culture - par : Antoine Dhulster - En novembre 2000, la superpuissance américaine est interrogée à l'aube d'une nouvelle ère. Experts français et américains débattent des défis politiques, économiques et militaires des États-Unis entre isolationnisme et expansionnisme. - réalisation : Emily Vallat - invités : Denis Lacorne Politiste, directeur de recherche au Centre de Recherches Internationales (CERI) de Sciences Po. Auteur notamment de Les Frontières de la tolérance, Gallimard, 2016.; Pierre Melandri Historien, professeur émérite des universités à Sciences Po; Hervé Coutau-Bégarie; Michel Aglietta Professeur émérite à l'université Paris-Ouest et conseiller scientifique au CEPII et à France Stratégie. Il a été membre de l'Institut universitaire de France et membre du Haut Conseil des finances publiques.; Antony Blinken Ancien secrétaire d'état adjoint des Etats-Unis pendant la présidence Obama; Stanley Hoffmann Professeur de sciences politiques à Harvard
Part of a daily deluge of connected episodes this week to honor the goddess, my Life Path 8 and Pisces
durée : 00:04:38 - Le Reportage de la rédaction - En 2007, deux ans après la mort de Zyed et Bouna à Clichy-sous-Bois, Farid Zerzour, alors jeune comédien, décide de lancer son théâtre au cœur du quartier prioritaire dont il est originaire, celui des Fossés-Jean, à Colombes, dans les Hauts-de-Seine. Depuis, il y accueille les habitants.
durée : 00:04:40 - Le Reportage de la rédaction - Les émeutes de 2005 avaient entraîné une redéfinition de la politique de la ville. Depuis dix ans, l'objectif est de réduire les écarts entre les 1 400 quartiers prioritaires de la ville et les autres quartiers des agglomérations. Quel bilan ? Reportage à Melun, dans le quartier de l'Almont.
In metastatic breast cancer, resistance to therapy remains one of the most challenging aspects to care. A key driver of resistance in hormone receptor-positive, HER2-negative disease is the ESR1 mutation, a genetic change that alters the estrogen receptor and limits the effectiveness of certain standard therapies. In this episode, CANCER BUZZ speaks with Eleonara Teplinsky, MD, FASCO, head of breast and gynecologic medical oncology at Valley-Mount Sinai Comprehensive Cancer Care, about how the ESR1 mutation shapes treatment decisions and explains communication strategies, such as the "lock-and-key" model. Then CANCER BUZZ speaks with Maimah Karmo, president and CEO of Tigerlily Foundation about the importance of communicating with patients in ways that foster clarity and compassion through relatable analogies. Guest: Eleonora Teplinsky, MD, FASCO Medical Oncologist Valley Mount Sinai Comprehensive Cancer Care Paramus, NJ Maimah Karmo President/CEO Tigerlily Foundation "If you had molecular testing of your tumor done at the time of diagnosis, that may not be enough. If there is disease progression, we might need to repeat it. So it's really important to stress that there are points in the disease course where we're going to be checking for these biomarkers." - Teplinsky "The more that we can know about the tumor, how it's going to behave, what treatment it may or may not respond to, really can help us." - Teplinsky "Having a physician that is a true partner with the patient, that has a relationship, that's trusted, and that feels safe and secure, it's really, really critical." - Karmo Resources: Unlocking the Conversation: Navigating ESR1 Mutations in Metastatic Breast Cancer
durée : 00:04:48 - Le Reportage de la rédaction - La représentation des quartiers populaires dans les médias traditionnels a toujours suscité des crispations chez les habitants et de la colère. En 2005, après la mort de Ziyed et Bouna, de nouveaux acteurs ont émergé ainsi qu'un nouveau récit. Mais la défiance reste profondément ancrée.
✨✨ If you've been wondering what your Incarnation Cross really means, and how it ties into the themes showing up in your life right now, I'd love for you to join me for Incarnation Cross Unlocked on Sunday, November 9th.It's a live workshop where we'll look at how your cross reveals the energetic story you're here to live and what it's trying to express through you.Early bird registration closes November 2nd at midnight, so if this feels like a yes, now's the time to grab your spot:https://tinyurl.com/54zm7ms5___________________________________________________________________________November brings a real shift in tone. We're leaving the tribe-centered Quarter of Duality and stepping into the Quarter of Mutation — the part of the cycle that's all about individuality, creativity, and inner transformation.In this episode, Hali and I look at what that means through the Sun and Earth transits for the month. It's a time when things start to feel a little different — like change is brewing under the surface, and something new is waiting to take shape.We also touch on how individuality doesn't mean doing it all alone. It's more about learning to trust what's uniquely yours, even if no one else sees it yet.If you've been feeling restless or like you're on the edge of something new (but can't name it yet), this episode will make a lot of sense.Chapters00:00 Introduction and Announcements04:40 Upcoming Workshop and Human Design Education09:30 Protests and Civic Engagement14:03 November Transits Overview18:45 Sun Gate 1 Earth Gate 227:43 Trusting Your Inner Guidance31:26 Sun Gate 43 Earth Gate 2336:42 Understanding the Genius to Freak Channel46:42 Sun Gate 14 Earth Gate 859:24 Sun Gate 34 Earth Gate 2001:00:42 Manifesting Generators and Their Energy01:10:39 Sun Gate 9 Earth Gate 1601:12:55 Collective Energies and Mastery01:16:18 Balancing Enthusiasm and Mastery01:20:35 Quality Over Quantity: The Importance of Focus01:22:04 Embracing Your Unique Contribution01:22:51 Transit Wrap Up01:23:47 Incarnation Cross of the Week01:28:05 Wrap Up Get new episodes (and bonuses) delivered straight to your inbox! https://danaphillips.substack.com/Tired of fighting your own energy? Your Human Design for Energetic Clarity guidebook translates your Human Design into practical wisdom so you can stop forcing what doesn't work and start living what does. Grab yours here: https://www.humandesignhive.com/guidebookWant insight on your design, on your time? Check out the customized Audio Human Design Reading: https://www.humandesignhive.com/audio_readingGrab your FREE copy of your Human Design chart (Bodygraph) Here: https://www.humandesignhive.com/freechartWebsite: https://www.humandesignhive.comemail: Dana@humandesignhive.com This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit danaphillips.substack.com/subscribe
Thème du jour : la télévision française face aux plateformes digitales.Au programme : comprendre comment les chaînes traditionnelles réinventent leur modèle face à la concurrence,analyser l'impact des plateformes sur l'investissement publicitaire, et débattre de l'avenir de l'écosystème TV français dans ce nouvel environnement.Une émission spéciale qui regroupe les experts et journalistes du groupe influencia.Julia Luczak-Rougeaux (Rédactrice en chef de Minted)Philippe Bailly (Fondateur de NPA Conseil)Cyrille Frank (Directeur des rédactions d'Influencia et de Minted) Hébergé par Acast. Visitez acast.com/privacy pour plus d'informations.
durée : 00:04:40 - Le Reportage de la rédaction - La mort de Zyed et Bouna avaient fait émerger le terme de "violences policières" même si les deux policiers ont été définitivement relaxés. Vingt ans plus tard, l'expression n'est pas reconnue comme une catégorie par les autorités mais une association témoigne de la vitalité du débat.
In this episode of JCO PO Article Insights, host Dr. Jiasen He summarizes the article, "Somatic Mutation Profiles of Colorectal Cancer by Birth Cohort" by Gilad, et al published October 11, 2025. TRANSCRIPT Jiasen He: Hello, and welcome to the JCO Precision Oncology Article Insights. I am your host, Jiasen He, and today, we will be discussing the JCO Precision Oncology article, "Somatic Mutation Profiles of Colorectal Cancer by Birth Cohort," by Dr. Gilad and colleagues. Early-onset colorectal cancer is defined as colorectal cancer diagnosed before the age of 50. Several reports have suggested that early-onset colorectal cancer has unique characteristics. Compared with late-onset colorectal cancer, early-onset colorectal cancer cases are more commonly found in the distal colon or rectum, tend to be diagnosed at more advanced stages, and may display unfavorable histologic features. Although the overall incidence of colorectal cancer has declined in recent decades, the incidence of early-onset colorectal cancer continues to rise. This increase appears to be driven by birth cohort effects. The reasons behind this rise remain unclear but are likely multifactorial, involving changes in demographics, diet, lifestyle, environmental exposures, and genetic predisposition. At the same time, studies have shown conflicting results regarding whether there are differences in the mutation profiles between early-onset and late-onset colorectal cancer. Therefore, it is crucial to explore whether colorectal cancer somatic mutational landscape differs across birth cohorts, as this could provide important insight into generational shifts in colorectal cancer incidence. To address this question, the authors conducted a retrospective study to characterize the mutation spectrum of colorectal cancer across different birth cohorts. Consecutive colorectal cancer patients who underwent somatic next-generation sequencing at the University of Chicago pathology laboratory between 2015 and 2022 were retrospectively identified. Tumors were tested for 154 to 168 genes and categorized as either microsatellite stable or high according to established thresholds. Patients with hereditary cancer syndromes or inflammatory bowel disease were excluded. Participants were then grouped into birth cohorts by decades, as well as into two major groups: those born before 1960 and after 1960. Genes that were identified in at least 5% of the sample were selected and grouped into 10 canonical cancer signaling pathways. These genes and pathways were then included in the analysis to explore their association with colorectal cancer across different birth cohorts and age groups. A total of 369 patients were included in the study, with a median birth year of 1955 and a median age at colorectal cancer diagnosis of 62.9 years. 5.4% were identified as having microsatellite-high tumors. The median tumor mutational burden was 5 mutations per megabase for microsatellite-stable tumors and 57.7 mutations per megabase for microsatellite-high tumors. Patients with microsatellite-high tumors tended to have earlier birth years and were diagnosed at an older age. However, after adjusting for potential confounders, neither birth year nor age remained statistically significant. Similarly, after controlling for confounders, no significant associations were observed between birth year or age and mutation burden. In this cohort, APC, TP53, and KRAS were the most frequently mutated genes. No statistically significant differences in the prevalence of gene mutations were observed across birth cohorts. Correspondingly, the most affected signaling pathways were the Wnt, TP53, and (RTK)/RAS pathways. Similar to the gene-level finding, no significant differences in the prevalence of these pathways were identified among birth cohorts. When examining patients born before and after 1960, the authors found that the older birth cohorts were diagnosed at an older age and had higher tumor mutational burden. However, no significant differences were observed in any of the genes or pathways analyzed. Among microsatellite-stable tumors, 18.3% were classified as early-onset colorectal cancer, while 81.1% were late-onset colorectal cancer. Consistent with previous reports, early-onset colorectal cancers in this cohort were more likely to be left-sided and more common among more recent birth cohorts. However, no significant differences were identified in any of the examined genes or pathways when comparing early-onset to late-onset colorectal cancer. In this cohort, a higher prevalence of early-onset colorectal cancer was observed among more recent birth cohorts, consistent with previous reports. Still, no distinct mutational signature was identified between the early and late birth cohorts. The authors proposed that the lack of distinct mutational profile by age or birth cohort may be due to the limited number of key molecular pathways driving colorectal cancer. Although environmental exposures likely differ across generations, the downstream effects may have converged on similar biological mechanisms, leading to comparable somatic mutations across cohorts. Alternately, they proposed that the observed birth cohort differences in colorectal incidence may be driven by distinct mutation signatures, epigenetic alterations, or changes in the immune microenvironment rather than variations in canonical gene mutations. As the authors noted, given the retrospective nature of this study, its modest sample size, and the predominance of advanced-stage tumors, larger prospective studies are needed to validate these findings. In summary, this study found no significant differences in the mutational landscape of colorectal cancer across birth cohorts or age groups. The authors proposed that the generational shift in colorectal cancer incidence is unlikely to be driven by changes in the underlying tumor genomics. However, larger prospective studies are needed to validate these findings. Thank you for tuning in to JCO Precision Oncology Article Insights. Do not forget to subscribe and join us next time as we explore more groundbreaking research shaping the future of oncology. The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement.
durée : 00:04:56 - Le Reportage de la rédaction - Le 27 octobre 2005, deux adolescents de Clichy-sous-Bois mouraient électrocutés après une course poursuite avec la police. Suivront 3 semaines d'affrontements avec les forces de l'ordre, dans plus de 300 villes de France. Vingt ans après, la colère des jeunes est empoignée par leurs mères.
This week, Professor Jan Vijg joins us to discuss the intricate relationship between DNA mutations, epigenetic drift, and aging. He explains the differences between mutations and epigenetic changes, the role of environmental factors, and the potential for reversing epigenetic changes. The conversation also touches on the implications of somatic mutations and the future of longevity research, particularly in relation to DNA repair mechanisms. Learn more about Professor Jan Vijg: https://einsteinmed.edu/faculty/11318/jan-vijg - Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0 Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com
durée : 00:04:22 - Le Reportage de la rédaction - En 2005, trois semaines de violences embrasent la France. À l'époque, les habitants des quartiers se mobilisent pour tenter d'apaiser la situation. Une démarche politique, mais vingt ans plus tard, que reste-t-il de cet engagement citoyen dans les quartiers populaires ?
In this bright and refreshing episode, Janina travels to the shores of Lake Garda to uncover one of Italy's most exciting and underrated white wine regions - Lugana DOC. Her guest is Fabio Zenato, president of the Consorzio Tutela Lugana DOC, who brings three generations of family knowledge and a deep passion for the local Turbiana grape. Together, they explore the true identity of Turbiana, the unique glacial soils of the region, and why Lugana wines can age far beyond expectations. Expect insights into clonal selection, microclimate, and terroir - all wrapped in stories of tradition, elegance, and discovery. Shownotes [01:53] Third-generation vintner Fabio Zenato reflects on childhood memories that shaped his connection to the vineyards of Lugana. [02:28] Family heritage and early experiences that inspired a lifelong dedication to the land and its vines. [04:46] Clarifying the genetic confusion surrounding the Turbiana grape and its historical misidentification. [04:57] Understanding the DNA difference between Turbiana, Verdicchio, and Trebbiano di Soave. [09:18] Mutation or clone — exploring how proximity to Soave influenced Turbiana's evolution. [10:41] Labeling inconsistencies and the importance of protecting the Turbiana name. [12:04] Tasting Tommasi Le Fornaci 2024 (£19.99 Cambridge Wine Merchants) and what to expect from a fresh, mineral-driven Lugana wine. [14:40] Locating Lugana: the southern shores of Lake Garda, between Lombardy and Veneto. [19:27] The influence of Lake Garda's breezes and surrounding topography on vineyard climate. [20:33] The role of elevation - from 60 to 100 meters - and how slight altitude differences affect freshness and balance. [22:02] Exploring Monte Lupo 2015 from Cobue and understanding why Turbiana has remarkable aging potential. [24:47] How Lugana wines maintain acidity and evolve with nutty, floral, and mineral complexity over time. [27:40] Introducing La Rifra Riserva 2022 - structure, richness, and longevity in the glass. £24.99 D Vino Wines [28:53] Defining what makes a Lugana Riserva: minimum aging, depth, and stylistic differences. [32:53] The story behind Benedictus 2023 from Le Morette — the philosophy and inspiration behind its name. £22 The Wine Rack [34:41] Winemaking approach: lees aging, oak influence, and the balance between richness and minerality. [38:05] Food pairing ideas — from seafood to risotto, and how Lugana's texture makes it versatile. [40:05] Tasting Feliciana 'Serce' Riserva 2022 — €27.95 Woodberrys.ie [40:36] Travel tips: flying into Verona for the easiest route to Lugana and Lake Garda. [42:59] Must-try local dishes and regional specialties to pair with Turbiana wines. [45:28] A new generation of winemakers bringing innovation through sparkling and sweet styles. [46:50] Corte Sermana Duerive 2023 — bright, delicate, and grown by the lake, where the vines feel the breeze off Garda's shores. [49:07] The perfect Lugana moment — sunshine, lake views, and a chilled glass of Turbiana.
Der Ausbruch der Vogelgrippe trifft in Deutschland vor allem Kraniche. Grund könnte eine fehlende Herdenimmunität für eine besondere Mutation des H5N1-Viruses sein. Doch auch andere Vögel sind betroffen. Menschen sollten ebenfalls vorsichtig sein. Brose, Maximilian www.deutschlandfunk.de, Forschung aktuell
Join The Deep Dive(Life-changing teachings for spiritual mastery, guided sound journeys, and access to live community gatherings to share your most authentic self) https://iamemilioortiz.com/the-deep-d...In this visionary interview, Richard Rudd — creator of the Gene Keys — joins Emilio Ortiz to explore one of the most profound themes in human evolution: the path of love, commitment, and transformation. Together they dive deep into Gene Key 29, which emphasizes the importance of surrendering to the heart's journey, even when faced with uncertainty. This dialogue weaves together the mysteries of DNA mutations, collective healing, and Gaia's awakening, offering a rare glimpse into the birth of the future human. Beyond the teachings of the Gene Keys, Emilio and Richard reflect on the contrasts between the creative process and AI, highlighting how technology can accelerate output but often lacks the depth of authentic human creativity. This episode illuminates the possibilities of a coming epoch where Gaia and humanity evolve together, where DNA mutations may spark new potentials, and where each of us is invited to become a living expression of infinity, wisdom, and awakening.Over the past several decades, Richard has dedicated his life to unraveling the mysteries of human consciousness and evolution, and from his initial download at 29, has developed a unique and transformative system for unlocking human potential using the power of the Gene Keys. Through his books, workshops, and online courses, Richard has helped countless individuals around the world to awaken to their true potential and discover their life's purpose. The Gene Keys is a system of spiritual and personal growth that draws on a variety of wisdom traditions, including astrology, human design, the I Ching, and the Kabbalah. At its core, the Gene Keys is a map of human consciousness that helps individuals to unlock their highest potential and transcend the limitations of their past conditioning. Join Richard Rudd for his upcoming London event (2025)
In this episode we connect genetics + central dogma to the next big step: how cells copy DNA and what happens when it goes wrong.What you'll learn (MCAT-high yield):Semi-conservative replication: why each daughter DNA has one old + one new strandOrigins of replication & replication bubblesKey enzymes: helicase, SSB proteins, topoisomerase, DNA pol III & I, primase, ligaseLeading vs. lagging strands and Okazaki fragmentsProofreading & repair: exonuclease activity, mismatch repair, nucleotide excision repair (UV/thymine dimers)Mutation types: silent, nonsense, frameshift (+ why location matters)Where this shows up in cell cycle, cancer biology, and classic experimental set-ups (knockouts)Perfect for MCAT Bio/Biochem passages that love replication, mutations, and repair pathways.Want to learn more? Shoot us a text at 415-855-4435 or email us at podcast@jackwestin.com!
Aujourd'hui, Didier Giraud, éleveur de bovins, Charles Consigny, avocat, et Flora Ghebali, entrepreneure dans la transition écologique, débattent de l'actualité autour d'Alain Marschall et Olivier Truchot.
Avant d'être une icône mondiale, le hamburger était un sandwich de rue. Né il y a plus de 135 ans aux États-Unis, ce sandwich simple en apparence raconte une histoire bien plus complexe : celle de la mondialisation et des mutations de nos habitudes alimentaires. Plaisir coupable pour les uns, fétiche réinventé pour les autres, le burger unit toutes les générations et dit beaucoup de nos sociétés. Yasmine Boudaka évoque l'histoire d'un des symboles culinaires américains avec Pierre Leclercq, historien de l'alimentation et auteur du Petit traité du burger, paru aux Éditions du Sureau. Sujets traités : burger, sandwich, États-Unis, mondialisation , mutations, Merci pour votre écoute Un Jour dans l'Histoire, c'est également en direct tous les jours de la semaine de 13h15 à 14h30 sur www.rtbf.be/lapremiere Retrouvez tous les épisodes d'Un Jour dans l'Histoire sur notre plateforme Auvio.be :https://auvio.rtbf.be/emission/5936 Intéressés par l'histoire ? Vous pourriez également aimer nos autres podcasts : L'Histoire Continue: https://audmns.com/kSbpELwL'heure H : https://audmns.com/YagLLiKEt sa version à écouter en famille : La Mini Heure H https://audmns.com/YagLLiKAinsi que nos séries historiques :Chili, le Pays de mes Histoires : https://audmns.com/XHbnevhD-Day : https://audmns.com/JWRdPYIJoséphine Baker : https://audmns.com/wCfhoEwLa folle histoire de l'aviation : https://audmns.com/xAWjyWCLes Jeux Olympiques, l'étonnant miroir de notre Histoire : https://audmns.com/ZEIihzZMarguerite, la Voix d'une Résistante : https://audmns.com/zFDehnENapoléon, le crépuscule de l'Aigle : https://audmns.com/DcdnIUnUn Jour dans le Sport : https://audmns.com/xXlkHMHSous le sable des Pyramides : https://audmns.com/rXfVppvN'oubliez pas de vous y abonner pour ne rien manquer.Et si vous avez apprécié ce podcast, n'hésitez pas à nous donner des étoiles ou des commentaires, cela nous aide à le faire connaître plus largement. Hébergé par Audiomeans. Visitez audiomeans.fr/politique-de-confidentialite pour plus d'informations.
Nels and Vincent discuss research which shows a shift from the rule that living organisms produce same-species offspring: an ant that produces individuals from two distinct species. Hosts: Nels Elde and Vincent Racaniello Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiEVO Links for this episode Join the MicrobeTV Discord server David Baltimore interview (TWiV 100) One mother for two species (Nature) Timestamps by Jolene Science Picks Nels – Dr. Bill Rom, NYU canoes every lake connected by a portage trail in the Boundary Waters in Minnesota Vincent – Google just made photography obsolete Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twievo@microbe.tv
REDIFF - Comment communiquer dans le couple lorsque se profile une mutation d'un des conjoints ? Qui est le plus souvent lésé et comment cela peut-il être vécu ? En compagnie de Caroline Dublanche, Paul Delair revient sur les témoignages et autres moments qui ont marqué le direct. Chaque soir, en direct, Caroline Dublanche accueille les auditeurs pour 2h30 d'échanges et de confidences. Pour participer, contactez l'émission au 09 69 39 10 11 (prix d'un appel local) ou sur parlonsnous@rtl.frHébergé par Audiomeans. Visitez audiomeans.fr/politique-de-confidentialite pour plus d'informations.
In today's episode, we had the pleasure of speaking with Stephen Liu, MD, about the use of tepotinib (Tepmetko) in patients with metastatic non–small cell lung cancer (NSCLC) harboring MET exon 14 skipping alterations. Dr Liu is an associate professor of medicine at Georgetown University, as well as the director of Thoracic Oncology and head of Developmental Therapeutics at the Georgetown Lombardi Comprehensive Cancer Center in Washington, DC. In our exclusive interview, Dr Liu discussed key efficacy and safety findings from the phase 2 VISION trial (NCT02864992) that led to the FDA approval of tepotinib for this indication; the comparable response rates seen between tissue and liquid biopsy results, as well as across NSCLC treatment lines; and the importance of early biomarker testing, including RNA sequencing, to identify actionable mutations and optimize treatment.
Aging is more than disease—it's the steady decline of function. In this episode of Longevity by Design, Dr. Gil Blander speaks with physicist-turned-biotech innovator Dr. Peter Fedichev about why resilience, not diseases, holds the key to longer lives.Peter explains how his background in theoretical physics shaped his approach to biology and aging. He outlines why startups, not large institutions, are now leading innovation in longevity science. Drawing from physics, he describes aging as a series of “jumps” between states, each leaving the body more fragile.The discussion moves from the limits of current drugs to the promise of new approaches. Peter argues that reducing fluctuations and increasing molecular fidelity could unlock far greater gains in healthspan and lifespan. Listeners gain a fresh lens on what drives aging, where the real breakthroughs may come from, and why the next frontier in longevity will require rethinking the problem altogether. Guest-at-a-Glance
Humans haven't been around for hundreds of thousands of years. We're all descended from Adam and Eve just a few thousand years ago. But what about the animals?
The rate at which mistakes pile up in the DNA we inherit from our mothers contradicts evolutionary ideas.
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