Alteration in the nucleotide sequence of a genome
For bonus content, check out our Patreon! patreon.com/wehaveconcernsHey! If you're enjoying the show, please take a moment to rate/review it on whatever service you use to listen.Here's the iTunes link: http://bit.ly/wehaveconcerns And here's the Stitcher link: http://bit.ly/stitcherwhconcernsJeff on Twitter: http://twitter.com/jeffcannataAnthony on Twitter: http://twitter.com/acarboniLink to the story: https://www.space.com/astronaut-spaceflight-cancer-dna-mutations-studyIf you've seen a story you think belongs on the show, send it to email@example.com or leave it on the subreddit: http://reddit.com/r/wehaveconcerns
Raising Public Awareness About the Dangers of Gene Editing In This Podcast: Jeffrey Smith returns to the Urban Farm Podcast to talk about what he calls “GMO 2.0”, an easily attainable technology with the power to permanently change the genetic makeup of every living thing on earth. The foods we eat are already being changed and we are already being affected in ways we don't yet understand, yet there are no controls in place to ensure the changes are safe. Jeffrey illuminates the very real dangers we face and tells us how we can fight back. Don't miss an episode! visit UrbanFarm.Org/blog/podcast Jeffrey Smith is a bestselling author, award-winning filmmaker and celebrated public speaker. He has influenced the behavior and health of millions of people worldwide through his books like Seeds of Deception, and Genetic Roulette, and his podcast Live Healthy Be Well. Jeffrey is the founding executive director of the Institute for Responsible Technology, which has started a global education campaign called Protect Nature Now with the documentary titled “Don't Let the Gene Out of the Bottle”, which won a Telly Award. Visit www.UrbanFarm.org/Podcast-by-episode-titles for the show notes on this episode, and access to our full podcast library! Protecting the Microbiome.
Der Fall der Schauspielerin Angelina Jolie sorgte für Schlagzeilen: Bei ihr wurde eine vererbbare Genmutation nachgewiesen, die das Risiko für Brust- und Eierstockkrebs erhöht. Auch Marlies M. (46) ist von einer solchen Mutation betroffen und bereits zwei Mal an einer aggressiven Art von Brustkrebs erkrankt. Sie erzählt, wie sich bei ihr der Verdacht auf eine genetische Veranlagung erhärtet hat. Zu Wort kommt auch Salome Riniker, eine auf Genetik und Brustkrebs spezialisierte Onkologin. Sie führt genetische Beratungen durch und klärt Ratsuchende auf.
Today, in episode 636 our expert Infectious Disease Doctor and Community Health Specialist discuss what you need to know about Public Health. We talk about how astronauts are at a higher risk of experiencing DNA mutations, as well as new research that shows how baker's yeast could be used to develop new cancer medication. As always, join us for all the Public Health information you need, explained clearly by our health experts. Website: NoiseFilter - Complex health topics explained simply (noisefiltershow.com) Animations: NoiseFilter - YouTube Instagram: NoiseFilter (@noisefiltershow) • Instagram photos and videos Facebook: NoiseFilter Show | Facebook TikTok: https://www.tiktok.com/@noisefiltershow --- Send in a voice message: https://anchor.fm/noisefilter/message
Our second episode on the evolution debate considers three more bones of contention: where do different species come from? Are we all commonly descended from a single source, or does God intervene? Then we consider homo sapiens, and whether science supports the Genesis account of humankind having an original Adam and Eve couple. Lastly we look at the Fall, and question if this can be seen as a real event in space and time, or instead has evolutionary biology proven death, predation and suffering were baked into creation long before human beings chose to sin. Subscribe to the Matters of Life and Death podcast: https://pod.link/1509923173 If you want to go deeper into some of the topics we discuss, visit John's website: http://www.johnwyatt.com For more resources to help you explore faith and the big questions, visit: http://www.premierunbelievable.com
Featuring perspectives from Dr Lecia Sequist, including the following topics: Introduction: Journal Club with Lecia V Sequist, MD, MPH (0:00) Case: A woman in her early 70s with Stage IIB adenocarcinoma of the lung and an EGFR exon 19 mutation— Adam R Miller, MD (19:26) Case: A man in his late 70s with metastatic adenocarcinoma of the lung and an EGFR L858R mutation develops hemoptysis from an “escape lesion” on osimertinib — Priya Rudolph, MD, PhD (24:59) Case: A man in his early 70s with metastatic adenocarcinoma of the lung (PD-L1 high) and an EGFR L858R mutation experiences disease progression on pembrolizumab — Sandip Patel, MD (28:45) Case: A woman in her mid 60s with metastatic adenocarcinoma of the lung with an EGFR exon 20 insertion with multiple brain and bone metastases (PD-L1
In episode #106 Troy shares his expertise as the founder of a pharmaceutical company and his personal story experiencing infertility with his wife. Troy has always been interested in health research, and he discovered the MTHFR mutation issue in 2010. He began a deep dive into this issue as it relates to fertility and pregnancy, and he was amazed by how many people are affected. With the right tests, it was discovered that his wife had the MTHFR mutation. Proper supplementation allowed her to get pregnant and they were able to have their second child. We discuss the difference between folic acid and folate, how the MTHFR mutation affects fertility and pregnancy, and how proper folate supplementation can make a big difference. References are listed below, and Troy is offering a discount code for your first bottle of prenatal vitamins from his company, Centurion Labs. Topics Discussed: infertility, folic acid, folate, MTHFR mutation, prenatal vitamins CONNECT WITH TROY - centurionlabs.com Use coupon code HOPE for 67% off your first bottle of prenatal vitamins! MISCARRIAGE HOPE DESK RESOURCES- Miscarriage Hope Desk aims to help women struggling miscarriage, pregnancy loss and recurrent miscarriages (RPL), by providing the following resources- - Library of Articles, found here- https://miscarriagehopedesk.com/library/understanding-why/ - Instagram Community- https://instagram.com/miscarriagehopedesk - Facebook Community- https://www.facebook.com/groups/1617075958466247/ - Free Miscarriage Lab Checklist- https://miscarriagehopedesk.com/labs - Free Weekly Newsletter- http://miscarriagehopedesk.com/newsletter FREE MEAL PLANS Do you need help getting healthy, tasty meals on the table? Check out our sponsor Prep Dish, PrepDish.com/mhd to get 2 weeks FREE! SHOW NOTES- https://miscarriagehopedesk.com/podcast/ Get a FREE Miscarriage Lab Testing Checklist- MiscarriageHopeDesk.com/labs REFERENCES: Scaglione, F., Panzavolta, G., Folate, Folic Acid and 5-methyltetrahydrofolate are not the same thing, Xenobiotica. Feb. 2014 Servy, Edouard, et.al., MTHFR isoform carriers. 5-MTHF (5-methyl tetrahydrofolate) vs. folic acid: a key to pregnancy outcome: a case series. Journal of Assisted Reproduction and Genetics. https://doi.org/10.1007/s10815-018-1225-2 Greenberg, J. Multivitamin Supplementation During Pregnancy: Emphasis on Folic Acid and L-Methylfolate. Reviews in Obstetrics & Gynecology. 2011, Vol. 4 pg 126-127. D'Elia, PQ., et.al., MTHFR polymorphisms C677T and A1298C and associations with IVF outcomes in Brazilian women. Reproductive Biomedicine Online 2014 Jun;28(6):733-8. doi: 10.1016/j.rbmo.2014.02.005. Naqvi, H., et.al., Role of 677C® T polymorphisms a single substitution in methylenetetrahydrofolate reductase (MTHFR) gene in North Indian infertile men. Molecular Biology Reports. Feb. 2014; 41(2):573-9. Mfady, DS, et. al., Associations of variants in MTHFR and MTRR genes with male infertility in the Jordanian population. Gene. 2014 Feb 15;536(1):40-4. doi: 10.1016/j.gene.2013.12.001. Gava, MM, et.al., Polymorphisms in folate-related enzyme genes in idiopathic infertile Brazilian men. Reproductive Sciences 2011 Dec;18(12):1267-72. doi: 10.1177/1933719111411729. Shen, O., et.al., Association of the Methylenetetrahydrofolate Reductase Gene A1298C Polymorphism with Male Infertility: A Meta-Analysis Updated Estimates of Neural Tube Defects Prevented by Mandatory Folic Acid Fortification, Centers for Disease Control (CDC): Morbidity and Mortality Weekly Report (MMWR), January 16, 2015. McGowan, E., et.al., Association Between Folate Metabolites and the Development of Food Allergy in Children. Journal of Allergy and Clinical Immunology. January 2020; 8(1):132-140. McStay, Catrina, Maternal Folic Acid Supplementation during Pregnancy and Childhood Allergic Disease Outcomes: A Question of Timing. Nutrients. 2017 February. Wang, T., et. al., Is Folate Status a Risk Factor for Asthma or Other Allergic Diseases?, Allergy, Asthma & Immunology Research. 2015 November; 7(6): 538-546. Whitrow, Melissa, et. al., Effect of Supplementatl Folic Acid in Pregnancy on Childhood Asthma: A Prospective Birth Cohort Study. American Journal of Epidemiology. October 2009. Vol. 170, No. 12.
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.09.15.508178v1?rss=1 Authors: Mitchell, M., Cook, L. F., Shiers, S., Tavares-Ferreira, D., Akopian, A. N., Dussor, G., Price, T. J. Abstract: Fragile X Mental Retardation Protein (FMRP) regulates activity-dependent RNA localization and local translation to modulate synaptic plasticity throughout the CNS. Mutations in the FMR1 gene that hinder or ablate FMRP function cause Fragile X Syndrome (FXS), a disorder associated with sensory processing dysfunction. FXS pre-mutations are associated with increased FMRP expression and neurological impairments including sex dimorphic presentations of chronic pain. In mice, FMRP ablation causes dysregulated DRG neuron excitability and synaptic vesicle exocytosis, spinal circuit activity, and decreased translation-dependent nociceptive sensitization. Activity-dependent, local translation is a key mechanism for enhancing primary nociceptor excitability which promotes pain in animals and humans. These works indicate that FMRP likely regulates nociception and pain at the level of the primary nociceptor or spinal cord. Therefore, we sought to better understand FMRP expression in the human dorsal root ganglion (DRG) and spinal cord using immunostaining in organ donor tissues. We find that FMRP is highly expressed in DRG and spinal neuron subsets with substantia gelatinosa exhibiting the most abundant immunoreactivity in spinal synaptic fields. Here, it is expressed in nociceptor axons. FMRP puncta colocalized with Nav1.7 and TRPV1 receptor signals suggesting a pool of axoplasmic FMRP localizes to plasma membrane-associated loci in these branches. Interestingly, FMRP puncta exhibited notable colocalization with calcitonin gene-related peptide (CGRP) immunoreactivity selectively in female spinal cord. Our results support a regulatory role for FMRP in human nociceptor axons of the dorsal horn and implicate it in the sex dimorphic actions of CGRP signaling in nociceptive sensitization and chronic pain. Copy rights belong to original authors. Visit the link for more info Podcast created by PaperPlayer
Deep within a dilapidated building hidden away in a dark alley, one Saul Tenser lies in his LifeFormWare bed anticipating the growth of something new in his body. This growth, a new organ, does not come as a surprise to Tenser or his performance partner Caprice. Mutations and transformations of this kind have been around for a while in this seemingly drab world. But are these "inner beauties" anomalies, or an evolutionary gift? In this episode, we talk about Crimes of the Future, a body horror film directed by one of the principal originators of the genre. We present our critiques of the film, ask questions about human evolution and sexual desire, draw comparisons with the original Crimes of Future, and dive deeper into the social commentary of the film. Watch this film and share your thoughts about it with us! Mentioned in this episode: Crimes of the Future - David Cronenberg Not mentioned in this episode but worth checking out: Why The Human Body Sucks, and How To Fix It (AsapSCIENCE) --- Send in a voice message: https://anchor.fm/we-might-be-tables/message
Journaliste tourisme, Roman Pommier revient sur les crises actuelles du secteur du voyage : transport aérien, crises, revenge travel, mutations et nouvelles tendances du voyage. Un épisode riche, sans langue de bois ! Ce que vous allez apprendre dans cet épisode : -pourquoi le transport aérien traverse une crise en ce moment -pourquoi le prix des billets d'avion augmente -les effets de la crise du Covid sur le secteur -comment les entreprises du tourisme font face -l'impact du covid de nos jours -l'effet revenge travel de cet été -où va-t-on dans les prochains mois ? -le voyage lointain en crise ? -un repli sur soi sur la durée ? -en quoi les prochains mois vont être déterminants pour la suite -le boom du voyage local et les nouvelles tendances -greenwhasing ? Les entreprises du tourisme face au changement climatique -notre rapport face au changement climatique et au voyage -la passion de Romain pour le voyage en stop Son profil Linkedin Mes liens : ★★ Gratuit : Le programme Voyager Plus + Le Manifeste du voyageur https://bit.ly/3wtwsht ★★ Mon livre "Libre d'être digital nomad", Ed .Diateino. https://bit.ly/36pYKPl
Jeff Goldblum is on the verge of revolutionizing transportation, but then a fly gets in the ointment. The week the Fried Squirms view Cronenberg's take on the classic horror, The Fly. Support our Patreon! www.patreon.com/FriedSquirms Listen to more Fried Squirms at www.friedsquirms.com Check out all earVVyrm podcasts at www.earvvyrm.com Email us at firstname.lastname@example.org
In today's episode Jeffrey continues the discussion on this urgent imperative. Jeffrey talks about the 7 reasons why gene editing is dangerous and unpredictable. To summarize, the 7 Reasons are: Cutting the wrong place Sloppy repairs Mixing genes Mutant proteins Insertion damage Mutations from the process Epigenetic Inheritance The Institute for Responsible Technology is working to protect you & the World from GMOs (and while we're at it, Roundup®...) To find out exactly how we do this and to subscribe to our newsletter visit https://www.responsibletechnology.org/ Join us at Protect Nature Now to Safeguarding Biological Evolution from GMOs 2.0. The place to get critical up to date information, watch our short film and most importantly, learn easy ways for you to take action against this existential threat. Visit: https://protectnaturenow.com/ Watch the film: Secret Ingredients Watch "Don't Let the Gene Out of the Bottle" Get the book: "Seeds of Deception" IG @irtnogmos Facebook @responsibletechnology YouTube @TheInstituteforResponsibleTechinology Twitter @TheInstituteforResponsibleTechnology
Out of the chapel, into the fire! The Gang continues to survive, but what else is in store in this horror-filled castle? Bruno takes a few steps forward, Lucky has a lot of things, Mammoth enjoys watching, and Mina is not stupid, just euphoric. The Professional Casual Network continues their play through of The Enemy Within Campaign. Twitch: Twitch.tv/professionalcasualnetwork Youtube: https://www.youtube.com/channel/UCfUOaJjpMfgRFWL7Z996lyQ Bearded Dragon Games (Pick up all your gaming needs): BeardedDragonGames.Online (use code 'professionalcasual' for free shipping in the continental US!) A special thanks to our Patron at https://l.facebook.com/l.php?u=http%3A%2F%2FPatreon.com%2Fprofessionalcasual%3Ffbclid%3DIwAR00ZOS4ImPUKbbVunOwdEeGg91kLKkR9KGwRq2n46aWx2QPNd9vLT8nWVE&h=AT17ZULXrF_tgmVfID7Wgg2dQvWTvczC_QFkpaYw1S8tS4n2iowcjY3vGXed_nGbOEOEd2-mAvRaC9DrHUI1cYWxY-1pdAcUFZgPzwJ9RajDDBpcen9DvcNyyqL-jXm_JA (Patreon.com/professionalcasual) : Thank you to our most recent Patrons! Thank you! Stephen S., Brad A., Matt A., Brian W., Timothy G., VPotter, Mike D., Erik G., Thoras, Justin K., Tepo C., Matt T., Rusty, Ara M., CyanidaCola, Nick A., Soren R., Kara N., Cliff K., David B., Cj K., David Q., Ben N., Syrpent, Zachary M., Robert W., Goodatthisgame, Christian H., Rakdos, Will J., Otis H, Troj, Kalle H., David H., John O., Mikasaz, OmnusProtocol, Jonaspdv, Steve T., Chris and Nicky, William, AW B., Sam M., Kristoffer w., Luka J., Lexa W., Cyder D., Joe M., Paul H., Kevin C., Joe W., Alexandre R., Scott F., Nerdtism, Joe L., Richard G., Dani2Time, Michael M, Rich M., Soul Eater, Aaron H., Eric B., Quinn B., John S., William S., Rob M., Rob, Franz B., Film-Lars, Leslie S., Matt F., Paul S., Christopher T., Matt L., Zane T., Thomas T, Joe J., Jens R., Oliver H., Mikolaj W., Andrew, Zach C., Justliketheplant, Neil L., Jared S., Mikael N., Taylor M., George F., Tom M., Devin M., Nicholas W., Jonas P., Jonathan L., Simon P., Gareth G., Jacob Y., Lady_Leah, Devin M., David R., Will B., Stephan S., Brian Y., William S., Path,Tim D., Simon W., Jake C., Theo A., Heber R., Ben R., Vaughan A., Daniel S., Lars, Taylor H., Blarin R., Gervasio L., Adam D., Craig G., Kevin C., WreckMyPodcast, Charlie S., Witchdream, Anthony R., Sarah B., Dan C., Dani, and Lindsay F. Mailing Address: P.O. Box G, West Oneonta, NY 13861, United States Voicemail: 603-803-3235 (Country Code 001) Drive-Thru RPG: https://www.drivethrurpg.com/browse.php?affiliate_id=3002007&fbclid=IwAR3AMyfrAOFoUjyamJV9Jo_69ZNBq1GVpPyB1bEOFjWjX5PjIbGiKVdXkI8 (https://www.drivethrurpg.com/browse.php?affiliate_id=3002007) Professional Casual Gear: https://professionalcasual.creator-spring.com/? (https://professionalcasual.creator-spring.com/? ) Built Bar (Use link or use code 'professionalcasual' at checkout for discount): https://l.facebook.com/l.php?u=https%3A%2F%2Fbuiltbar.com%2F%3Ffbclid%3DIwAR1csKQAHcNAS-dT3-7pH8242Z4K7X0tT_fPeBBm702ZyBuTRCl_2qw-3HE%23%3Fbaapp%3DPROFESSIONALCASUAL&h=AT04e1Uy6B22XSluNC1VWMWJWl8_jzAMRZtBEBhZG1LMe9AgcTF8-Sglzlt_ynRR_VGPEkiuATs1mrDzQZa7M7BLGT80YaiPFl7tYtXRnX_lsu1ee5aEYHqSC490iV7Vkg (https://builtbar.com#?baapp=PROFESSIONALCASUAL) Use Code 'professionalcasual' for 15% off RAZE Energy: https://reppsports.com/?rfsn=5472644.3e7a1c&utm_source=refersion&utm_medium=affiliate&utm_campaign=5472644.3e7a1c&fbclid=IwAR0hK6RhHFqmOwEJSYM2yw1GrIV6-4GZqN8-Dw1lhHO0UzCriccyxcMhsTY (https://reppsports.com/?rfsn=5472644.3e7a1c&utm_source=refersion&utm_medium=affiliate&utm_campaign=5472644.3e7a1c)
Today on the Ether we have the Mutation and Chill space hosted by the Space Ape Society. You'll hear from Space Skellies, Bryson, Space Ape 2ic, Sunnyside Reapers NFTs, Hooligan, Just&True, PS Labs, TIZZ, Sven, Demosthenes, CosmosKen, Jared, and more! Recorded on September 12th 2022. If you enjoy the music at the end of the episodes, you can find the albums streaming on Spotify, and the rest of your favorite streaming platforms. Check out Project Survival, Virus Diaries, and Plan B wherever you get your music. Thank you to everyone in the community who supports TerraSpaces.
View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Dr. Matt Kaeberlein is a globally recognized expert on the biology of aging and recurring on The Drive. In this episode, Matt explains his research findings on nutrition as it relates to aging and longevity, including the results from his recent review article in Science. From there, he and Peter dive deep into the literature on calorie restriction (CR), explaining the nuance, benefits for lifespan and healthspan, and potential downsides of CR. He discusses the epigenetic changes that occur with age and potential benefits and downsides of epigenetic reprogramming, often viewed as a panacea for reversing aging. Matt also explains the impact of dietary protein on aging, including the interesting dichotomy around how protein, a critical macronutrient, and rapamycin, a geroprotective molecule, have opposite effects on mTOR. Additionally, he talks about low-protein vs. high-protein diets and their effects on muscle mass and mortality, as well as the impact of IGF-1 signaling and growth hormone on lifespan. We discuss: Challenges with understanding the effects of nutrition and studying interventions for aging [3:30]; How Peter's and Matt's convictions on nutrition and thoughts optimal health have evolved [8:15]; Calorie restriction for improving lifespan in animal models [16:15]; Utility of epigenetic clocks and possibility of epigenetic reprogramming [22:00]; Mutations and changes to the epigenome with aging [31:45]; Epigenetic reprogramming: potential benefits and downsides and whether it can work in every organ/tissue [35:15]; First potential applications of anti-aging therapies and tips for aging well [43:00]; Impact of calorie restriction on the immune system, muscle mass, and strength [47:00]; Insights from famous calorie restriction studies in rhesus macaques [55:00]; An evolutionary perspective of the human diet [1:03:45]; Antiaging diets: Separating fact from fiction—Matt's 2021 review in Science [1:12:30]; Mouse models of time-restricted feeding in the context of calorie restriction [1:19:30]; Nutritional interventions that consistently impact lifespan in mice, and concerns around efficacy in humans [1:27:00]; Differing impact of calorie restriction when started later in life [1:31:00]; Lifespan extension with rapamycin in older mice [1:37:15]; Relationship between protein intake and aging, and mouse studies showing protein restriction can extend lifespan [1:43:30]; Impact of protein intake on mTOR, and why inhibition of mTOR doesn't cause muscle loss [1:50:45]; Low-protein vs. high-protein diets and their effects on muscle mass, mortality, and more [1:55:30]; The impact of IGF-1 signaling and growth hormone on lifespan [2:06:30]; Parting thoughts on the contribution of nutrition to healthspan and lifespan [2:19:45]; More. Connect With Peter on Twitter, Instagram, Facebook and YouTube
The mutations occur spontaneously in noncoding stretches of DNA that control gene expression. The post Mutations disrupting chromatin interactions contribute to autism appeared first on Spectrum | Autism Research News.
In this second half of episode three (originally posted to our Patrons in December, 2020) Adam, Tish, and Alex share some of our current writing and research, including a report on a much-overlooked group of writers who tried to claim sci-fi for communism in the 1930s, and an overview of the work of Hugo-nominated fantasy writer Chuck Tingle. You can listen to the first half of the episode, "Four Seasons Totalitarian Landscaping," at the Locust Review website. Selected works and subjects discussed in part two: Alexander Billet, "The FBI's War on Folk Music,"Jacobin; Aaron Leonard, The Folk Singers and the Bureau; Nadine Hubbs, Rednecks, Queers, and Country Music; Johnny Cash, "One Piece at a Time;" Johnny Paycheck, "Take This Job and Shove It;" Michael Hall, "Put Down That Pig;" John Michel, "Mutation or Death," (1937); Sean Guynes, "Mutate or Die: Eighty Years of the Futurians' Vision," The Pulp Magazine Archive; Los Angels Review of Books; Chuck Tingle's website; Chuck Tingle, Trans Wizard Harriet Porber And The Bad Boy Parasaurolophus: An Adult Romance Novel. Locust Radio 3.5 was produced by Drew Franzblau, hosted by Alexander Billet, Tish Markley and Adam Turl, with music by Omnia Sol.
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.09.09.507282v1?rss=1 Authors: Lee, K., Lee, C. Abstract: The creation of mutant mice has been invaluable for advancing biomedical science, but is too time- and resource-intensive for investigating the full range of mutations and polymorphisms. Cell culture models are therefore an invaluable complement to mouse models, especially for cell-autonomous pathways like the circadian clock. In this study, we quantitatively assessed the use of CRISPR to create cell models in MEFs as compared to mouse models. We generated two point mutations in the clock genes Per1 and Per2 in mice and in MEFs using the same sgRNAs and repair templates for HDR and quantified the frequency of the mutations by digital PCR. The frequency was about an order of magnitude higher in mouse zygotes compared to that in MEFs. However, the mutation frequency in MEFs was still high enough for clonal isolation by simple screening of a few dozen individual cells. The Per mutant cells that we generated provide important new insights into the role of the PAS domain in regulating PER phosphorylation, a key aspect of the circadian clock mechanism. Accurate quantification of the mutation frequency in bulk MEF populations provides a critical basis for optimizing CRISPR protocols and time/resource planning for generating cell models for further studies. Copy rights belong to original authors. Visit the link for more info Podcast created by PaperPlayer
Imagine a world without mutants. I don't mean those super-powered heroes that populate the comics and movies from Marvel. I'm talking about you, me, and everyone else we know. We are all mutants trying to survive. For show notes and more, please visit https://EvolutionTalk.com Written, Produced, & Narrated by: Rick Coste
The conversation around adult development and integral consciousness continues to expand and evolve. In this conversation with author and philosopher Jeremy Johnson we explore Jean Gebser's notion of development, temporics, the unperspectival, the perspectival and the aperspectival, the move from sense-directed thinking to “senseful awareing”, the magic and the mythic and the invitation of this moment. Jeremy Johnson is an author (Seeing Through the World: Jean Gebser and Integral Consciousness), publisher (Integral Imprint), managing editor (Integral Leadership Review), podcaster (Mutations) and integral philosopher. His academic research, writing, and publishing advocates new forays into integrative thinking and praxis—aligning the scholastic, poetic, and spiritual—as existentially crucial work for pathfinding in a time of planetary crisis. Jeremy currently serves as president for the International Jean Gebser Society, and is working on his doctorate in the Philosophy of Religion at the California Institute of Integral Studies. His second book, Fragments of an Integral Future (Integral Imprint) is forthcoming in late 2022. → Our live online coach training “The Neuroscience of Change” starts September 29th 2022 ← Visit coachesrising.com to see our acclaimed online coach trainings and other offerings.
durée : 00:10:18 - L'invité de 7h50 du week-end - par : Patricia Martin - Philippe Torreton, comédien dans la pièce "Lazzi", de Fabrice Melquiot, est l'invité de la matinale du week-end de France Inter ce dimanche. La première de la pièce a lieu mardi aux Bouffes du Nord, à Paris. Carine Bécard s'est rendue sur place.
In this provoking episode Coach Renée dives into the historical topic of friendship. Approach this episode with caution, for it is sure to stir some feelings and trigger some type of reaction. Listen intently as Coach Renée gently nudges each listener towards healthy friendships. FOLLOW Coach Renée on FB & IG: @iamreneeroberts NEED A LIFE COACH?: www.iamreneeroberts.com
Landon brings his entire $10,000 iPhone collection to the podcast and introduces each of his 17 iPhones to Liz and Ryan. Liz updates everyone on her art project she's been painting. Ryan opens up about an issue he always (not always, but sometimes) has, and tries to find a solution. Liz has a skeletal mutation in her fingers?Follow us!Instagram: https://instagram.com/lifeinthemomentpodFacebook: https://facebook.com/lifeinthemomentpodLandon: https://instagram.com/landongingerichLiz: https://instagram.com/_charmeling_Ryan: https://instagram.com/ryanattaway14
During the process of protein translation, the cell matches three letters in DNA for each amino acid. But there are 4 x 4 x 4 = 64 possible 3-letter combination and only 20 amino acids. This means that most amino acids have more than one code and that many mutations do not change the amino acids in the resulting protein. For decades, mutations at these sites were seen as 'silent', but this can no longer be accepted. Instead, it is now clearly understood that most mutations in these sites, even if the amino acid sequence in the protein is unchanged, are measurably bad for the organism. There are various reasons for this, as Dr Rob explains, but this creates a giant headache for evolutionary theory. Removing this class of 'irrelevant' mutations means that evolution has even more mathematical difficulties. On the other hand, the new information tells us that life was designed with an amazing degree of exactitude and precision. All quotations and references can be found in my article Carter R, Mutations are more harmful than we thought: silencing the ‘wobble' in the codon table, creation.com/silent-mutations-harmful, 25 August 2022.
Nels and Vincent discuss how duplication of a gene encoding a transcription factor led to evolution of a novel cell type in the slime mold Dictyostelium. Hosts: Nels Elde and Vincent Racaniello Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiEVO Links for this episode Gene duplication leads to novel cell type (Current Biol) Evolution of multicellularity (TWiEVO 11) Letters read on TWiEVO 81 Time stamps by Jolene. Thanks! Science Picks Nels – Dall-E artificial intelligence meets art Vincent – John Bonner's slime mold movies Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to email@example.com
How do we think about treatment of lung cancer? Recap on staging (see Episode 025) * Pro-tip: Highly recommend that you “forget” about the actual staging and focus more on the individual T, N, and M status * Tumor size:**T1a
Marc Boiron (@boironattorney) is the Chief Legal Officer of the Polygon companies and a strategic advisor at Variant Fund, an early-stage fund investing in web3. He's also a board member of the DeFi Education Fund. Marc recently published an excellent article, titled “Sufficient Decentralization: A playbook for Web3 builders and lawyers.” In this episode, we dive deep into Marc's article to highlight how builders and lawyers should think about sufficient decentralization. We also touch on Marc's journey and his thoughts on the current state of crypto regulation. Show highlights: [2:03] Marc's introduction to Bitcoin [9:27] Why decentralization is important [17:08] Best practices in decentralization [24:00] The critical point in Marc's paper [37:40] Airdrops & the Howey Test [42:00] Mutation doctrine [53:00] Tools for DAO communities & much more. Resources: Sufficient Decentralization: A Playbook for web3 Builders and Lawyers Thanks for listening! If you enjoyed this episode, please consider leaving a review. You can subscribe to the newsletter to stay updated on the latest episodes. Disclaimer: Jacob Robinson and his guests are not your lawyer. Nothing herein or mentioned on the Law of Code podcast should be construed as legal advice. The material published is intended for informational, educational, and entertainment purposes only. Please seek the advice of counsel, and do not apply any of the generalized material to your individual facts or circumstances without speaking to an attorney.
Ca ne t‘a pas échappé, la techno est partout. Depuis 30 ans la techno s'est infiltrée partout dans nos vies. Petit à petit, pas à pas. Au fil du temps, nous avons vu fleurir avec les nouvelles technologies des nouveaux usages, des nouvelles habitudes, des nouveaux modèles aussi. Que tu sois génération X, Y, Millenials ou encore Gen Z, il nous est de plus en plus difficile, voire impossible pour certains, de nous souvenir du jour où nous n'avons pas été en contact avec un objet technologique, avec un outil numérique. Quels sont les impacts sur nous tous liés à ces mutations technologiques ? Et si, pour mieux comprendre, on se faisait un petit revival des technos ? Un petit revival de nos meilleurs souvenirs aussi ? Pour reprendre un coup de jeune et bien comprendre l'impact de ces mutations technologiques, l'invité de cet épisode du podcast est Philippe Dewost, le Directeur Général d'EPITA et l'auteur de l'ouvrage "De Mémoire Vive" paru aux éditions « Première partie ». Si ça te dit d'écouter toutes les rencontres du matin sur les plateformes de podcasts traditionnelles, c'est ici https://smartlink.ausha.co/ledigitalpourtous
Years ago, Lefty endured a horrific fight for survival against a subterranean community of cannibal mutants. Now she is going back down, for a parley.Edited and produced by Jeff Davidson. Special thanks go out to patrons Bret, Kevin, Kathryn, and AndyFeatured music :Kevin Macleod - Jet fueled vixen, The Escalation, Giant Wyrm, Unseen HorrorsLobo Loco - Burning Sunshine, Lockdown City, You Got My HorsesAnd Chelsea Oxendine with the theme music "Jet Fueled Vixen" Kevin MacLeod (incompetech.com)Licensed under Creative Commons: By Attribution 4.0 Licensehttp://creativecommons.org/licenses/by/4.0/Please subscribe through Buzzsprout, Stitcher, Spotify, Podchaser, or iTunesFind me on social media on Instagram Facebook and Twitter, or email me direct at AScaryHomeCompanion@gmail.comSupport our PATREON page! And check out the Redbubble merch shop. Support the show
Un premier cas de transmission de la variole du singe de l'être humain au chien a été rapporté dans le journal médical "The Lancet". Deux hommes contaminés ont transmis le virus à leur lévrier, à Paris. Au micro d'Europe 1, Gilles Pialoux, chef du service des maladies infectieuses et tropicales de l'hôpital Tenon à Paris, donne des conseils pour éviter toute contamination.
Ben Woodard is a highly accomplished contemporary philosopher and cultural theorist who works to devise conceptions of reality beyond and productive of the human. In this episode of the Zer0 Books Archive, Adam from Acid Horizon and Kenny speak with Ben Woodard about his 2012 book Slime Dynamics: Generation, Mutation, and the Creep of Life. This book explores what Woodard terms dark vitalism and the sliminess of life, which challenge the thesis that life is inherently positive. Woodard's philosophy is also guided by his naturalistic reading of Schelling and his attempts to creatively escape anthropocentrism's metaphysical and ethical limits.Slime Dynamics: https://www.johnhuntpublishing.com/zer0-books/our-books/slime-dynamicsBen's blog: https://naughtthought.wordpress.com/about/Support Zer0 Books on Patreon: https://www.patreon.com/zerobooksSubscribe: http://bit.ly/SubZeroBooksFacebook: https://www.facebook.com/ZeroBooks/Twitter: https://twitter.com/zer0books-----Other links:Check out the projects of some of the new contributors to Zer0 Books:Acid HorizonPatreon: https://www.patreon.com/acidhorizonpodcastYouTube: https://www.youtube.com/c/acidhorizonMerch: crit-drip.comThe Philosopher's Tarot from Repeater Books: https://repeaterbooks.com/product/the-philosophers-tarot/The Horror VanguardApple Podcasts: https://podcasts.apple.com/us/podcast/horror-vanguard/id1445594437Patreon: https://www.patreon.com/horrorvanguardBuddies Without OrgansApple Podcasts: https://podcasts.apple.com/gb/podcast/buddies-without-organs/id1543289939Website: https://buddieswithout.org/Xenogothic: https://xenogothic.com/Support Daniel Tutt's work by visiting the Torsion Groups Patreon account: https://patreon.com/torsiongroups
Learn about epigenetics and the MTHFR gene. Many people seek help from doctors for their chronic debilitating symptoms and are given vague diagnoses along with prescriptions rather than testing to find the root cause. MTHFR mutation is a common but under diagnosed condition that could be causing life disruptions for you or your child. But the C D C website downplays it and tries to denigrate the people who are helping people get better. Find out what might help . www.blueskiesandgreenpastures.com/epigenetics www.methy-life.com Buy methyfolate and B12 from Amazon --- Send in a voice message: https://anchor.fm/blueskiesandgreenpastures/message
Lung cancer specialized testing in NSCLC: What do we do if we biopsy a suspected metastatic lesion?* Immunohistochemistry (IHC): **Confirm if it is metastatic NSCLC **Confirms the histology of the NSCLC (such as adenocarcinoma vs. squamous cell)**Used to determine the type of chemotherapy that can be administered for treatment *PDL1 testing: **PDL1 is a protein expressed by certain cancer cells allowing them to evade the immune system (“fake mustache analogy”).**Also confirmed by IHC**This protein is targetable!**Often measured as:***Total protein expression (TPS): The number of positive tumor cells divided by the total number of viable tumor cells multiplied by 100%***Composite protein expression (CPS): The number of positive tumor cells, lymphocytes and macrophages, divided by the total number of viable tumor cells multiplied by 100%*Molecular testing: **We discuss this in detail in Episode 005**Genetic information from the tissue sample**Always better to get sample from soft tissue than from bone**Why is this important?***To be able to identify “driver mutations”****What is it? Important mutations that may be “driving” oncogenesis****Many of these have drugs that directly target these mutationsPrognostic vs. predictive biomarkers:*Prognostic biomarkers: Mutations or changes that give information about the cancer's overall outcome regardless of therapy*Predictive biomarkers: Mutations that provide information about how a cancer may respond to a particular drug Cell-free DNA (AKA “liquid biopsy”):*Special tests that can detect microscopic amounts of cancer cell DNA within the patient's blood which may also be used to find prognostic/predictive biomarkers*Ongoing studies to see if this can be used to find relapse of diseasePlease visit our website (TheFellowOnCall.com) for more information Twitter: @TheFellowOnCallInstagram: @TheFellowOnCallListen in on: Apple Podcast, Spotify, and Google Podcast
It's time to get experimental with your voice as I'm joined by extreme metal vocalist and voice actor Sébastien Croteau. We discuss the different styles of throat singing, his unusual introduction this art form and the strange and wonderful place this has taken him in his career. To learn more about his work, check out the links below!Necrotic Mutation Website - https://www.necroticmutation.com/Youtube - https://www.youtube.com/c/NecroticMutationJean Dit Preview - https://www.youtube.com/watch?v=-1F4OwhJUcMPrivate Vocal Lessons via Chris Liepehttps://www.mymusicalvoice.com/p/private-lessons-w-sebastien-croteauMonster FactoryWebsite - https://lafabriquedemonstres.com/en/Youtube - https://www.youtube.com/c/LaFabriquedeMonstresInstagram - https://www.instagram.com/lafabriquedemonstres/Twitter - https://twitter.com/DeMonstresFacebook - https://www.facebook.com/lafabriquedemonstres/Tiktok - https://www.tiktok.com/@themonster_factory?Fandomentals Social Media Donate to the Podcast - https://ko-fi.com/fandomentalspodcastTeePublic Store - https://www.teepublic.com/stores/fandomentals-podcast?ref_id=25862Twitter - https://twitter.com/fandomentalspodInstagram - https://instagram.com/fandomentalspodEmail – firstname.lastname@example.org Artwork Designed by Alex JenkinsWebsite - www.hexdesigns.orgInstagram - https://www.instagram.com/hexshadowTwitter - https://twitter.com/hexghosts Thank you for checking out this episode and be sure to subscribe for more content!
In this episode, we wonder out loud why Singaporeans are so fixated by MacDonalds, work through Gym Culture and why everyone's freaking out about gyms closing, and get a lesson from Kishan on Mutations and how not to be afraid of them (GET VACCINATED!). +++ Music used "Victory" by Monplaisir; "Camper" by Phillip Gross; "Level 4" by Monplaisir; "Japan", "Too Grimy", "Sofa Fitness" by Lobo Loco; and "Seattle" by Yung Kartz. Check them out on freemusicarchive.org.
In this week's episode new research suggesting that, in patients with transplant-eligible multiple myeloma, adding daratumumab to first-line combination regimens may be a more cost effective strategy than saving it for second-line use. We'll also review the work of researchers who applied base-editing technology to develop a complex and potent CAR T cell product for potential “off-the-shelf” use in patients with T-cell leukemias and other CD7-positive malignancies. Finally, we'll review a paper that elucidates the role of SETBP1 mutations in chronic neutrophilic leukemia, pointing the way toward a potential multi-pronged therapeutic approach to this rare myeloproliferative neoplasm.
In this episode of the Epigenetics Podcast, we caught up with Nada Jabado from McGill University to talk about her work on oncohistones as drivers of Pediatric Brain Tumors. Nada Jabado and her team were amongst the first to identify mutations in Histone 3.3 Tails which lead to differentially remodeled chromatin in pediatric glioblastoma. Mutations that occur include the Lysine at position 27 and the Glycine at position 34. If those residues are mutated it will influence the equilibrium of chromatin associated proteins like the Polycomb Repressive Complex (PRC) and hence domains of heterochromatin will be shifted. This, in turn, will lead to differential gene expression and development of developmental disorders or cancer. References Schwartzentruber, J., Korshunov, A., Liu, X. Y., Jones, D. T., Pfaff, E., Jacob, K., Sturm, D., Fontebasso, A. M., Quang, D. A., Tönjes, M., Hovestadt, V., Albrecht, S., Kool, M., Nantel, A., Konermann, C., Lindroth, A., Jäger, N., Rausch, T., Ryzhova, M., Korbel, J. O., … Jabado, N. (2012). Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma. Nature, 482(7384), 226–231. https://doi.org/10.1038/nature10833 Kleinman, C. L., Gerges, N., Papillon-Cavanagh, S., Sin-Chan, P., Pramatarova, A., Quang, D. A., Adoue, V., Busche, S., Caron, M., Djambazian, H., Bemmo, A., Fontebasso, A. M., Spence, T., Schwartzentruber, J., Albrecht, S., Hauser, P., Garami, M., Klekner, A., Bognar, L., Montes, J. L., … Jabado, N. (2014). Fusion of TTYH1 with the C19MC microRNA cluster drives expression of a brain-specific DNMT3B isoform in the embryonal brain tumor ETMR. Nature genetics, 46(1), 39–44. https://doi.org/10.1038/ng.2849 Papillon-Cavanagh, S., Lu, C., Gayden, T., Mikael, L. G., Bechet, D., Karamboulas, C., Ailles, L., Karamchandani, J., Marchione, D. M., Garcia, B. A., Weinreb, I., Goldstein, D., Lewis, P. W., Dancu, O. M., Dhaliwal, S., Stecho, W., Howlett, C. J., Mymryk, J. S., Barrett, J. W., Nichols, A. C., … Jabado, N. (2017). Impaired H3K36 methylation defines a subset of head and neck squamous cell carcinomas. Nature genetics, 49(2), 180–185. https://doi.org/10.1038/ng.3757 Chen, C., Deshmukh, S., Jessa, S., Hadjadj, D., Lisi, V., Andrade, A. F., Faury, D., Jawhar, W., Dali, R., Suzuki, H., Pathania, M., A, D., Dubois, F., Woodward, E., Hébert, S., Coutelier, M., Karamchandani, J., Albrecht, S., Brandner, S., De Jay, N., … Jabado, N. (2020). Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA for Gliomagenesis. Cell, 183(6), 1617–1633.e22. https://doi.org/10.1016/j.cell.2020.11.012 Chaouch, A., Berlandi, J., Chen, C., Frey, F., Badini, S., Harutyunyan, A. S., Chen, X., Krug, B., Hébert, S., Jeibmann, A., Lu, C., Kleinman, C. L., Hasselblatt, M., Lasko, P., Shirinian, M., & Jabado, N. (2021). Histone H3.3 K27M and K36M mutations de-repress transposable elements through perturbation of antagonistic chromatin marks. Molecular cell, 81(23), 4876–4890.e7. https://doi.org/10.1016/j.molcel.2021.10.008 Related Episodes Cancer and Epigenetics (David Jones) Epigenetics & Glioblastoma: New Approaches to Treat Brain Cancer (Lucy Stead) Targeting COMPASS to Cure Childhood Leukemia (Ali Shilatifard) Contact Active Motif on Twitter Epigenetics Podcast on Twitter Active Motif on LinkedIn Active Motif on Facebook Email: email@example.com
Dr. Arunima Agarwal Back To School Episode S4E1: Show Notes. This start of the school year leaves us with many questions. Will children be masking, or not masking? Whether to vaccinate, or not? With no clear end in sight, it seems that the onslaught of new variants, plus the annual flu season, leaves us with few answers as to what to do. Today, we welcome Dr. Arunima Agarwal, a New York-based pediatrician who is here to answer some of the questions you might have as your kids start school this Fall. Tune in to hear Dr. Agarwal's recommendations on vaccinations, masks, sanitizer, and navigating side effects for your child over two, over five, and over 12 years old. She points us in the direction of reliable, objective resources and recommends how we can limit our go-to information sources to avoid confusion and overwhelm. Dr. Agarwal reminds us that our most important resource for all things vaccination is our medical practitioner, and explains the science behind why a surgical mask is superior to a cloth one, before leaving us with some great advice to implement immediately. Thanks for tuning in! Key Points From This Episode: Welcome to today's guest, Dr. Arunima Agarwal. Dr. Agarwal's recommendation that kids are double vaccinated before school starts. Why parents should not be alarmed if vaccines become mandated. Why it is understandable that parents have felt anxious about vaccinating their kids. Dr. Agarwal's opinion on government communication around the vaccine. The evolution of vaccination for children over 12, over five, and under five. The best way to prepare for flu season as a parent: get your flu vaccine closer to October, consult with your practitioner about timing, Good habits kids have picked up on during the pandemic that will protect them from flu. Why MRNA is a better system than previous vaccines. Mutations, boosters, and vaccine variations. Why there has been such a wide variety of information on the vaccine. Where to find the most objective information: the CDC, John Hopkins. Navigating side effects, with the most common one being arm pain for 18 and up. The slight uptick in Myocarditis as a side effect in older teenage males. Choosing to spread the dosage out over more than 21 days to combat the risk. Why your pediatrician is the best possible resource on any vaccine. Wearing the cloth mask and why the surgical mask or M95 is superior. Why nobody should be wearing a mask 24/7 and why there is no danger to masking kids ages 2 and up. Why it is important to explain to kids why they need to wear masks. Hand sanitizer, supervision, sensitive skin, and over-sanitizing. Links Mentioned in Today's Episode: Dr. Arunima Agarwal Dr. Arunima Agarwal on TwitterDr. Arunima Agarwal on LinkedInJohn HopkinsThe CDCThe Zen MommyZen Mommy InstagTMAC Fitness. 20 Minute Home Workouts Beginner and Advanced Workouts. No equipment. Each Workout Ends with a Meditation. BrandGo to ahimsahome.com to get your set of smart stainless steel dishes for your kiddos. Use code "ZENMOM" for 15% offexclusions on bundles, gift cards, and moveable meal collectionsSupport the show
Louise Moncla joins Nels and Vincent to review her use of genomics to understand emergence, evolution, and transmission of respiratory viruses including influenza virus H5N1, mumps virus, and SARS-CoV-2. Hosts: Nels Elde and Vincent Racaniello Guest: Louise Moncla Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiEVO Links for this episode Within-host diversity of influenza virus H5N1 (PLoS Path) Mumps virus outbreak in Washington (eLive) SARS-CoV-2 tight transmission bottlenecks (PLoS Path) Time stamps by Jolene. Thanks! Science Picks Nels – JWST Images Vincent – 3rd International Symposium on Infectious Diseases of Bats and Program Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to firstname.lastname@example.org
Course registration page Writing about the class Mutations community on Patreon Mutations homepage Music for Mutations podcast was composed by Pierre-Yves Martel --- Send in a voice message: https://anchor.fm/mutations/message
Sensitive to sulfur foods? Having difficulty detoxing? You might be dealing with this genetic defect. Listen to figure out what CBS mutations are, what causes them, and what impact they have on the body.01:03 - What is CBS mutation?02:53 - What is BH4?04:40 - CBS mutation health issues07:30 - What can you do about it?Trying to find an integrative medicine or functional medicine doctor who understands what you're going through? Lam Clinic does Telemedicine all over the world and is only a phone call away. 1. Educate yourself by visiting our website: www.lamclinic.com2. Call our office at 714-709-8000 to schedule an appointment. FIND US ONLINE HERE: » Website: https://www.lamclinic.com/» Facebook: https://www.facebook.com/lamclinic» Instagram: https://www.instagram.com/lam_clinic/» Tiktok: https://www.tiktok.com/@lamclinic» YouTube: https://www.youtube.com/LAMCLINIC
Educational Objectives • Review the targetable mutations RET, MET, and KRAS, including associated agents for the treatment of metastatic non-small cell lung cancer (NSCLC) • Discuss the ways a pharmacist may improve adherence, toxicity management, and outcomes for patients with metastatic NSCLC expressing RET, MET, and KRAS mutations Josiah D. Land, PharmD, BCOP Clinical Pharmacy Specialist – Thoracic Medical Oncology Department of Pharmacy Memorial Sloan Kettering Cancer Center New York, New York Josiah D. Land, PharmD, BCOP, has the following financial relationship with a commercial interest to disclose: Consultant (advisory board): Bristol Myers Squibb Pharmacy Times Continuing Education™ is accredited by the Accreditation Council for Pharmacy Education (ACPE) as a provider of continuing pharmacy education. This activity is approved for 0.5 contact hours (0.05 CEU) under the ACPE universal activity number 0659-0000-22-039-H04-P. The activity is available for CE credit through July 29, 2023. This activity is supported by educational funding provided by Amgen. Learn more about your ad choices. Visit megaphone.fm/adchoices
As we participate more and more consciously in our own unfolding, we need to ask what is working, what is holding us back, and how can we develop as individuals and collectively in a way that is in harmony with the wider ecosystem? In this conversation with Spring Cheng, Steve March and Jeremy Johnson we explore the concept of liminality, animated intelligence, constructive and destructive developmental methods, two key pathways to creating change, our relationality and connection to the ecosphere, and embracing diversity within and between us. Spring Cheng: Spring Cheng is the co-founder of Resonance Path Institute, a non-profit organization based in Seattle that pioneers research and practice to restore the sensing-feeling-Self to serve the emergence of collective consciousness and wholesome social organizations, and co-author of The Resonance Code. Jeremy Johnson: Jeremy is an author (Seeing Through the World: Jean Gebser and Integral Consciousness), publisher (Integral Imprint), managing editor (Integral Leadership Review), podcaster (Mutations) and integral philosopher. His academic research, writing, and publishing advocates new forays into integrative thinking and praxis—aligning the scholastic, poetic, and spiritual—as existentially crucial work for pathfinding in a time of planetary crisis. Jeremy currently serves as president for the International Jean Gebser Society, and is working on his doctorate in the Philosophy of Religion at the California Institute of Integral Studies. His second book, Fragments of an Integral Future (Integral Imprint) is forthcoming in late 2022. Steve March: Steve March is a senior faculty member of New Ventures West, and founder of the Aletheia school of integral development. He specializes in coaching leaders stepping into new and/or expanded roles and leaders who are burned out (or on the way to becoming burned out). He brings a deep and rich background of sixteen years working in the field of software development as a software engineer, quality manager, senior process consultant, and manager of organizational development. Visit coachesrising.com to see our acclaimed online coach trainings and other offerings. ***Join us for our FREE Coaching Summit THE EVOLUTION OF COACHING from July 7 - 21 2022***
View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Max Diehn is a Professor of Radiation Oncology at Stanford and a clinical radiation oncologist specializing in lung cancer. Max's research focuses on developing novel methods for detecting circulating tumor DNA in the blood of cancer patients and on elucidating the molecular pathways and genes associated with cancer. His interests also include uncovering biomarkers that can predict patient survival, responses to therapy, and disease recurrence. In this packed episode, Max discusses the history of blood-based cancer screening and the importance of understanding the predictive value of tests—sensitivity, specificity, negative predictive value, positive predictive value – and how these metrics play into cancer screening. Max then goes in depth on the topic of liquid biopsies, including the history, current landscape, and possible future of liquid biopsies as a cancer detection tool. He discusses how these non-invasive blood tests can detect DNA/RNA from tumor cells released into the blood as well as the different methods one can use to predict if a cancer is present. He gets granular on the topic of cell-free DNA/RNA signature, methylation patterns, and the importance of knowing mutation information, and he ends with a discussion on the exciting future of liquid biopsies and how we can possibly get to the panacea of cancer screening. We discuss: Max's training that planted the seeds for development of liquid biopsies [4:30]; Max's decision to specialize in radiation oncology [11:45]; A culture at Stanford that values research and physician scientists [17:00]; The motivation to develop liquid biopsies [19:15]; History of blood-based cancer screening and understanding the predictive value of tests [25:30]; Current state of lung cancer and the need for better screening [32:45]; Low-dose CT scans: an important tool for managing lung cancer but with limitations [42:00]; Using liquid biopsies to identify circulating tumor cells [47:00]; Liquid biopsy research moves from circulating tumor cells to cell-free DNA [1:03:00]; Zeroing-in on circulating tumor DNA in cell-free DNA [1:10:48]; Cell-free RNA and Max's vision for cancer detection from a blood sample [1:22:00]; Methylation patterns and other informative signatures found in DNA [1:24:30]; Mutation-based methods of liquid biopsies [1:26:30]; Understanding the sensitivity and specificity of a diagnostic test [1:30:30]; Existing clinical liquid biopsy tests and their limitations [1:37:30]; The future of liquid biopsies [1:44:00]; How we get to the panacea of cancer screening [1:52:00]; More. Connect With Peter on Twitter, Instagram, Facebook and YouTube