Alteration in the nucleotide sequence of a genome
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Aging is more than disease—it's the steady decline of function. In this episode of Longevity by Design, Dr. Gil Blander speaks with physicist-turned-biotech innovator Dr. Peter Fedichev about why resilience, not diseases, holds the key to longer lives.Peter explains how his background in theoretical physics shaped his approach to biology and aging. He outlines why startups, not large institutions, are now leading innovation in longevity science. Drawing from physics, he describes aging as a series of “jumps” between states, each leaving the body more fragile.The discussion moves from the limits of current drugs to the promise of new approaches. Peter argues that reducing fluctuations and increasing molecular fidelity could unlock far greater gains in healthspan and lifespan. Listeners gain a fresh lens on what drives aging, where the real breakthroughs may come from, and why the next frontier in longevity will require rethinking the problem altogether. Guest-at-a-Glance
Humans haven't been around for hundreds of thousands of years. We're all descended from Adam and Eve just a few thousand years ago. But what about the animals?
A new MP3 sermon from Answers in Genesis Ministries is now available on SermonAudio with the following details: Title: Mutations—A Challenge for Evolution Subtitle: Answers with Ken Ham Speaker: Ken Ham Broadcaster: Answers in Genesis Ministries Event: Radio Broadcast Date: 9/12/2025 Length: 1 min.
In this week's episode we'll learn about persistent changes in immune profiles in patients who have had diffuse large B-cell lymphoma, or DLBCL, and other cancers; that plasminogen activation and plasmin activity do not appear to play a role in routine physiological prevention of venous thromboembolism, or VTE; and about a novel mechanism that makes hematological malignancies carrying epigenetic mutations susceptible to PARP inhibitors.Featured Articles:Large B-cell lymphoma imprints a dysfunctional immune phenotype that persists years after treatmentPlasminogen activation and plasmin activity are not required to prevent venous thrombosis/thromboembolismTransposable elements as novel therapeutic targets for PARPi-induced synthetic lethality in PcG-mutated blood cancer
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A new MP3 sermon from Answers in Genesis Ministries is now available on SermonAudio with the following details: Title: Mutations Don’t Support Evolution Subtitle: Answers with Ken Ham Speaker: Ken Ham Broadcaster: Answers in Genesis Ministries Event: Radio Broadcast Date: 9/9/2025 Length: 1 min.
A new MP3 sermon from Answers in Genesis Ministries is now available on SermonAudio with the following details: Title: Mutations Don’t Support Evolution Subtitle: Answers with Ken Ham Speaker: Ken Ham Broadcaster: Answers in Genesis Ministries Event: Radio Broadcast Date: 9/9/2025 Length: 1 min.
A new MP3 sermon from Answers in Genesis Ministries is now available on SermonAudio with the following details: Title: Mutations Don’t Support Evolution Subtitle: Answers with Ken Ham Speaker: Ken Ham Broadcaster: Answers in Genesis Ministries Event: Radio Broadcast Date: 9/9/2025 Length: 1 min.
The rate at which mistakes pile up in the DNA we inherit from our mothers contradicts evolutionary ideas.
Il y a ceux pour qui tout semble couler de source… et ceux qui avancent, un pas après l'autre, à la force du travail. Ceux qui ne rentrent pas dans les cases, mais qui finissent par redessiner les contours de leur art.Cédric Andrieux fait partie de ceux-là.Dans ce premier épisode d'un diptyque exceptionnel, Les Sens de la Danse vous emmène à la rencontre d'un danseur au parcours aussi exigeant que passionnant — entre Bretagne, New York et Lyon, entre admiration et transmission, entre rigueur et intuition.Formé au Conservatoire national supérieur de musique et de danse de Paris, Cédric Andrieux rejoint à 21 ans l'une des compagnies les plus mythiques de l'histoire de la danse contemporaine : celle de Merce Cunningham. Dix années d'un travail rigoureux, abstrait, épuré — à l'image du chorégraphe américain qui a bouleversé la relation entre la musique et le mouvement, séparé les disciplines pour en faire surgir de nouveaux possibles.
Is your fertility struggle really about MTHFR—or could your genes be pointing to a much bigger story?If you've ever been told that an MTHFR mutation explains why you can't conceive—or if you've tried all the “clean living” advice and still aren't seeing results—this episode is for you. We explore how genetics, oxidative stress, and hidden nutrient weaknesses can quietly impact egg and sperm health, making pregnancy feel out of reach even when you're doing everything “right.”In this episode, you'll learn...-Why MTHFR is only one piece of the fertility puzzle and what else you must consider.-How oxidative stress and genetic predispositions directly influence egg and sperm quality.-The role of functional genetic testing in uncovering hidden causes of unexplained infertility and guiding personalized solutions.Press play now to uncover how your genes and environment interact—and how this knowledge can finally move you closer to growing the family of your dreams.
Kat Gourd, Acting Deputy Editor of The Lancet Oncology, is joined by Dr Linda Bi, Dr Ruchit Patel, Dr Chloe Gui, Dr Farshad Nassiri, and Dr Matija Snuderl, from institutions in the USA and Canada, to discuss two exciting papers on TERT expression and TERT promoter mutations in meningiomas.In these two cohort studies, the authors analyse the expression of TERT and TERT promoter mutations in meningiomas, assess their association with patient outcomes, and discuss the potential implications for patient management and the classification of these tumours.You can read the two Articles here:https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(25)00267-0/fulltext?dgcid=buzzsprout_icw_podcast_September_25_lanonchttps://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(25)00422-X/fulltext?dgcid=buzzsprout_icw_podcast_September_25_lanoncTell us what you thought about this episodeContinue this conversation on social!Follow us today at...https://thelancet.bsky.social/https://instagram.com/thelancetgrouphttps://facebook.com/thelancetmedicaljournalhttps://linkedIn.com/company/the-lancethttps://youtube.com/thelancettv
Et s'il existait des états de danse que l'on ne peut pas décrire, seulement traverser ?Dans ce Best Of de fin d'été, je vous propose un extrait profond et suspendu avec Nelson Ewandé, danseur, chorégraphe, champion du monde de popping et fondateur du collectif Enfants Prodiges.Dans ce passage rare, il partage ces instants où la danse nous déplace, nous transporte, nous transforme.Des moments où la conscience s'efface, où le corps se met à bouger sans que l'esprit ne le commande.Où l'on danse… mais sans plus rien contrôler.
Pour l'épisode de cette semaine, j'ai le plaisir de recevoir Rémi Aubert, co-CEO et cofondateur de AB Tasty.Nous avons enregistré cet épisode… les pieds dans le sable et face à la mer
Jay is excited to be back and even more excited by our guest this week. Taejon Romanik, guitarist and backup vocalist for the Wild Wild Wets, is back to announce a brand new album. We catch up with Taejon and discuss their latest album, Time Mutations, which drops on streaming services today. Get the album and some coffee here.Songs:Wild Wild Wets - “High Rider”Wild Wild Wets - “Sunshine Sue”Wild Wild Wets - “Disintegrate”Next up, News with Nick! Radiohead has released a live version of Hail to the Thief, Sony sues Napster, and Godspeed You! Black Emperor is no longer streaming anywhere.Song: Radiohead - “There There (Live)”Greg has a solid set of tunes to share this week via Three for Thursday. What if Louis Cole played the accordion, you ask? Introducing Anatole Muster. Oasis continues wowing audiences and we dive into an old track by Steely Dan.Songs:Anatole Muster - “Hope Walk”Oasis - “Little By Little (Live 25)”Steely Dan - “Peg”
Nels and Vincent discuss research on hidden evolutionary constraints that dictate the retention of coronavirus accessory gene, which was flagged by NIH as potentially dangerous gain-of-function research. Hosts: Nels Elde and Vincent Racaniello Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiEVO Links for this episode Join the MicrobeTV Discord server Hidden evolutionary constraints and retention of coronavirus accessory genes (Curr Biol) Timestamps by Jolene Science Picks Nels – NIH suspends dozens of pathogen studies over ‘gain-of-function' concerns and Mentorship and acts of kindness Vincent – Kennedy's case against mRNA vaccines collapses under his own evidence Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twievo@microbe.tv
In this episode, we review the high-yield topic of Type of DNA Mutations from the Biochemistry section.Follow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbullets
Send us a textAI Pathology & Genomics: A New Benchmark for Predicting Gene MutationsIf you still think visual quantification is “good enough” in pathology, think again. In this 27th episode of DigiPath Digest, I break down four transformative abstracts that show how AI is shifting our diagnostic landscape—from breast cancer segmentation to fibrosis assessment, and all the way to spatial immunology and the evolving immunoscore.If you're still relying on manual scoring, static staging systems, or single-marker immunohistochemistry, this episode will challenge you to look deeper—literally and algorithmically.
AI and genetic medicine are converging to transform how we diagnose, treat, and prevent disease. Gene Yeo, Ph.D., unites RNA biology with artificial intelligence to speed the path from genome sequencing to personalized RNA therapeutics. Advances in sequencing have reduced costs dramatically, making interpretation and translation into treatments the real challenge. Using deep learning and large datasets of RNA-binding proteins, Yeo predicts disease vulnerabilities and identifies therapeutic targets, including in neurodegeneration and muscular diseases. Alexis Komor, Ph.D., focuses on DNA, explaining human genetic variation—particularly single-nucleotide variants—and how genome editing technologies like CRISPR can target them. She highlights strategies to correct harmful mutations and explores precise, programmable interventions. Together, their research drives discovery and enables more effective, personalized therapies. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40459]
AI and genetic medicine are converging to transform how we diagnose, treat, and prevent disease. Gene Yeo, Ph.D., unites RNA biology with artificial intelligence to speed the path from genome sequencing to personalized RNA therapeutics. Advances in sequencing have reduced costs dramatically, making interpretation and translation into treatments the real challenge. Using deep learning and large datasets of RNA-binding proteins, Yeo predicts disease vulnerabilities and identifies therapeutic targets, including in neurodegeneration and muscular diseases. Alexis Komor, Ph.D., focuses on DNA, explaining human genetic variation—particularly single-nucleotide variants—and how genome editing technologies like CRISPR can target them. She highlights strategies to correct harmful mutations and explores precise, programmable interventions. Together, their research drives discovery and enables more effective, personalized therapies. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40459]
AI and genetic medicine are converging to transform how we diagnose, treat, and prevent disease. Gene Yeo, Ph.D., unites RNA biology with artificial intelligence to speed the path from genome sequencing to personalized RNA therapeutics. Advances in sequencing have reduced costs dramatically, making interpretation and translation into treatments the real challenge. Using deep learning and large datasets of RNA-binding proteins, Yeo predicts disease vulnerabilities and identifies therapeutic targets, including in neurodegeneration and muscular diseases. Alexis Komor, Ph.D., focuses on DNA, explaining human genetic variation—particularly single-nucleotide variants—and how genome editing technologies like CRISPR can target them. She highlights strategies to correct harmful mutations and explores precise, programmable interventions. Together, their research drives discovery and enables more effective, personalized therapies. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40459]
AI and genetic medicine are converging to transform how we diagnose, treat, and prevent disease. Gene Yeo, Ph.D., unites RNA biology with artificial intelligence to speed the path from genome sequencing to personalized RNA therapeutics. Advances in sequencing have reduced costs dramatically, making interpretation and translation into treatments the real challenge. Using deep learning and large datasets of RNA-binding proteins, Yeo predicts disease vulnerabilities and identifies therapeutic targets, including in neurodegeneration and muscular diseases. Alexis Komor, Ph.D., focuses on DNA, explaining human genetic variation—particularly single-nucleotide variants—and how genome editing technologies like CRISPR can target them. She highlights strategies to correct harmful mutations and explores precise, programmable interventions. Together, their research drives discovery and enables more effective, personalized therapies. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40459]
AI and genetic medicine are converging to transform how we diagnose, treat, and prevent disease. Gene Yeo, Ph.D., unites RNA biology with artificial intelligence to speed the path from genome sequencing to personalized RNA therapeutics. Advances in sequencing have reduced costs dramatically, making interpretation and translation into treatments the real challenge. Using deep learning and large datasets of RNA-binding proteins, Yeo predicts disease vulnerabilities and identifies therapeutic targets, including in neurodegeneration and muscular diseases. Alexis Komor, Ph.D., focuses on DNA, explaining human genetic variation—particularly single-nucleotide variants—and how genome editing technologies like CRISPR can target them. She highlights strategies to correct harmful mutations and explores precise, programmable interventions. Together, their research drives discovery and enables more effective, personalized therapies. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40459]
AI and genetic medicine are converging to transform how we diagnose, treat, and prevent disease. Gene Yeo, Ph.D., unites RNA biology with artificial intelligence to speed the path from genome sequencing to personalized RNA therapeutics. Advances in sequencing have reduced costs dramatically, making interpretation and translation into treatments the real challenge. Using deep learning and large datasets of RNA-binding proteins, Yeo predicts disease vulnerabilities and identifies therapeutic targets, including in neurodegeneration and muscular diseases. Alexis Komor, Ph.D., focuses on DNA, explaining human genetic variation—particularly single-nucleotide variants—and how genome editing technologies like CRISPR can target them. She highlights strategies to correct harmful mutations and explores precise, programmable interventions. Together, their research drives discovery and enables more effective, personalized therapies. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40459]
In this episode, we talk about our unforgettable experience celebrating the 35th anniversary of the TMNT movie in theaters! Our Radical Friends from Dimension X:Follow @EnterSagaArts and @FathomEntertainmentTMNT 35th Anniversary TicketsTMNT Evolution, Mutation and Reboot KickstarterAll Fathers Care for Their Sons (1990 TMNT Movie Scene)Kirklanardo's Regular Time Podcast!Gnarly Nick's Genesis Gems Podcast!Mondo Michael's 2 Dudes and a NES Podcast!Attack of the Big Zach's Booyakashow! TMNT Podcast!Rad Ryan's Talkin' Snikt Wolverine Podcast!Robatello's The Retro Junkies Podcast!Cowabunga Craig's Art/Comics Page!Check out Tubular Tara's Art/Comics Page!Check out Bodacious Beejay's Art/Comics Page!
Welcome to MrMaple Podcasts, your go-to destination for all things horticulture. Our playlist is a collection of podcasts that showcase various plants and interview renowned horticulturists. We aim to educate and inspire our listeners about the beauty of plants and the knowledge needed to cultivate them. Our podcasts cover a wide range of topics, from Japanese Maples, Conifers, Ginkgos, and Azaleas to interviews with experts in the field. Tune in every Sunday at 8PM eastern for a new episode and join us on this journey to discover the wonders of horticulture.
Ep. 161 - Sam McPheetersSam McPheeters was the frontman behind the infamous New York City based hardcore punk band Born Against. These days he is known as a writer, having authored books such as The Loom of Ruin and Mutations, as well as many articles across multiple national magazines.The lore and many stories surrounding Born Against aside, I was fascinated by Sam after discovering his amazing article on Vice, “The Troublemaker,” which is an astonishing interview with Doc Dart of the Crucifucks. Sealing the deal on becoming an enthusiastic devotee of his work was reading Mutations, a book that feels flat out dedicated to someone like me.Sam is a man praised by friends and peers who are diehard devotees of punk, yet also painted as the villain in many stories from more accessible hardcore lore such as the infamous Sick of It All debate on “Crucial Chaos.” I was interested in getting to know who Sam McPheeters really is, and I was not disappointed.We met up with Sam at an IKEA in Pomona, California, where we conducted this interview in one of their mock up living room setups. We discussed his childhood, Born Against, the good and the bad, his young adult years living in New York, his life after being in bands, his life today, and much more.
Send us a textToday's interview is one that I truly enjoy because it focuses on the patient's experience. Meet Dan Drydock Shockley, a Navy veteran who served in Operation Desert Storm, Operation Enduring Freedom, and Operation Iraqi Freedom. At the age of 51, after a routine colonoscopy, Dan was diagnosed with Attenuated Familial Adenomatous Polyposis—quite a mouthful, indeed. I will let Dan share the rest of his incredible story, as he is a gifted speaker. He serves as a live case presentation speaker for the Stanford School of Medicine's Molecular Foundations of Medicine course and the Stanford MS Program in Human Genetics and Genetic Counseling. Dan's story has undoubtedly impacted many individuals. Patient experiences are crucial for healthcare professionals; they are at the heart of why we do what we do. You will hear about the many connections that Dan forged throughout his journey. As I have told him, there are no coincidences in life, only divine interventions, which you will witness today. Dan is also a master of acronyms and created one based on his experience: Always Forge Ahead with a Purpose. Brilliant. In the five-minute snippet: Army, Navy, Air Force or Marines? For Dan's bio, visit my website (link below).California FAP Awareness WeekContact The Conversing Nurse podcastInstagram: https://www.instagram.com/theconversingnursepodcast/Website: https://theconversingnursepodcast.comYour review is so important to this Indie podcaster! You can leave one here! https://theconversingnursepodcast.com/leave-me-a-reviewWould you like to be a guest on my podcast? Pitch me! https://theconversingnursepodcast.com/intake-formCheck out my guests' book recommendations! https://bookshop.org/shop/theconversingnursepodcast I've partnered with RNegade.pro! You can earn CE's just by listening to my podcast episodes! Check out my CE library here: https://rnegade.thinkific.com/collections/conversing-nurse-podcast Thanks for listening!
It's Animals Attack August and this week we had guest Holly Chou (from X-Men 97) in the studio to talk about Alligator 2: The Mutation, a movie about a giant alligator who eats people again.Tune in next week when our movie will be... The Grey.-----Watch Holly Chou in X-Men 97 where she plays Jubilee!August 30 from 2pm-5pm Holly will be doing an in store signing at Legends Comics in Clovis, CA Jordan and Holly will be at Cape and Cowl Con at Faction Brewing in Alameda on Aug 24. Find out more here!August 28th, come to the Punch Line Comedy Club in Houston to see Matt and his wife Francesca Fiorentini! https://bit.ly/mattfranhtx
Featuring an interview with Dr Jorge Cortes, including the following topics: Overview of common molecular profiles in newly diagnosed acute myeloid leukemia (AML) (0:00) Clinical presentation of AML with a FLT3 mutation; implications of clinical data from the Phase III RATIFY trial of the FLT3 inhibitor midostaurin (5:38) Potential incorporation of a FLT3 inhibitor with azacitidine/venetoclax for transplant-ineligible patients with FLT3-mutant AML (10:32) Clinical benefit with quizartinib for patients with FLT3-like genetic profile; selection of FLT3 inhibitor as a component of initial therapy for individuals with AML with a FLT3-ITD mutation (14:04) Overview of FDA-approved IDH inhibitors enasidenib, ivosidenib and olutasidenib; differentiation syndrome as a class effect of IDH inhibitors in AML (20:31) Case: A woman in her late 60s with newly diagnosed AML with FLT3-ITD and NPM1 mutations receives 7+3 chemotherapy in combination with quizartinib (31:07) Case: A patient in their late 70s with multiple comorbidities and newly diagnosed IDH1-mutant AML (37:53) CME information and select publications
Dr Jorge Cortes from Georgia Cancer Center at Augusta University discusses patient cases and summarizes current treatment approaches for FLT3- and IDH1/2-mutant acute myeloid leukemia. CME information and select publications here.
Content Warning:This episode contains spooky themes, eerie sound effects, and mild horror elements.Mutations: Toxic TwentiesIn the roaring heart of a 1920s metropolis, two Marconi family mobsters, Vinny Marino and Sal Calderone, are making a late-night getaway with forty grand in stolen cash. But when their escape collides with a BuzzCon Chemical truck, a strange green mist spills into the streets — warping friends, neighbors, and allies into something unrecognizable.As they race through the city's underbelly — past a loyal paperboy, a trusted florist, and an old flame running a speakeasy — Vinny and Sal realize the infection isn't just around them… it's inside them.Morning brings more than daylight. It brings a city transformed — and a final stop at the boss's hideout that will change the family forever.This is Mutations: Toxic Twenties — a noir horror tale of gangsters, jazz, and a city where the gold has rotted to green.Disclaimer: This audio story was inspired by TMutations: Toxic Twenties, a scare zone coming to Halloween Horror Nights. It is an original, fan-created work based solely on publicly available information. No details, concepts, or materials were obtained through insider knowledge, and this production is in no way affiliated with or endorsed by Universal Parks & Resorts or Halloween Horror Nights.
Featuring a slide presentation and related discussion from Dr Jorge Cortes, including the following topics: Oncology Today with Dr Neil Love: Perspectives on New Datasets in FLT3- and IDH1/2-Mutant Acute Myeloid Leukemia — Dr Cortes (0:00) CME information and select publications
Dr Bill Nelson and Dr Nilo Azad discuss the decades-long research effort to develop treatments targeting KRAS mutations and the importance of federal funding in bringing those treatments to patients.
Could cancer actually disprove evolution? This fascinating discussion explores how cellular protection systems pose serious challenges to evolutionary theory. Three sophisticated mechanisms guard us against cancer: tumor suppressor genes that trigger cell suicide, proto-oncogenes that control division rates, and error-correcting systems that fix DNA damage. These complex systems must function perfectly from the start—they can’t evolve gradually. Mutations, supposedly evolution’s driving force, actually destroy rather than create. Dr Don Batten reveals how cancer research unexpectedly undermines the very foundation of evolutionary claims.
Mutation. It is the key to our evolution. As our cells constantly divide and reproduce and replicate our DNA, errors and inconsistencies develop, leading to the incredible variation of life that drives evolutionary change. This episode, we explore the genetic mechanisms behind mutation and we discuss how scientists study mutations to understand the evolutionary history of life on Earth. In the news: Neanderthal tools, caiman food, dancing dinosaurs, and ancient integument. Time markers: Intro & Announcements: 00:00:00 News: 00:09:25 Main discussion, Part 1: 00:40:50 Main discussion, Part 2: 01:35:00 Patron question: 02:28:55 Check out our website for this episode's blog post and more: http://commondescentpodcast.com/ Join us on Patreon to support the podcast and enjoy bonus content: https://www.patreon.com/commondescentpodcast Got a topic you want to hear about? Submit your episode request here: https://commondescentpodcast.com/request-a-topic/ Lots more ways to connect with us: https://linktr.ee/common_descent The Intro and Outro music is “On the Origin of Species” by Protodome. More music like this at http://ocremix.org Musical Interludes are "Professor Umlaut" by Kevin MacLeod (incompetech.com). Licensed under Creative Commons: By Attribution 3.0 http://creativecommons.org/licenses/by/3.0
Visser Three is still trying to find a way to reach the Pemalite ship. The ship that was hidden thousands of feet below the ocean's surface. A ship containing technology so advanced that it is superior to anything even the Andalites have built. And this time, the visser plans to find the ship so he can use the power to complete Earth's invasion. Jake, the other Animorphs, and Ax acquire additional deep-sea morphs in order to stop the visser's plan. But while trying to destroy the Yeerk ship, the kids make a startling discovery: an underwater civilization. Have the kids discovered Atlantis...or is it just another trap? -- Audiomorphs is an Animorphs podcast which is actually not so much a podcast as a bootleg Animorphs audiobook. Releases every Friday. Visit https://www.theapodcalypse.com/ Twitter: @audiomorphs
Ils sont treize et leurs photos sont à la Une de Cameroon Tribune. Treize candidats à la présidentielle d'octobre prochain, dont, le sortant, Paul Biya, 92 ans, qui brigue un 8e mandat… Et un absent de marque, donc : Maurice Kamto, le principal opposant, dont la candidature a été rejetée par Elecam, le Conseil électoral camerounais. « L'annonce a aussitôt fait l'effet d'un coup de tonnerre dans les médias camerounais, relève Le Point Afrique, même si beaucoup redoutaient ce scénario. Le Jour, quotidien de Douala, parle d'un “verrouillage politique assumé“, tandis que Mutations dénonce un “processus électoral biaisé dès l'entame“. Mutations qui s'interroge : “comment parler d'élections libres et crédibles quand le principal challenger est évincé sans motif officiel ?“ » Le Journal du Cameroun nous explique la raison de ce rejet : « son parti d'origine le MRC n'ayant pas d'élus, il lui était difficile d'investir Maurice Kamto comme candidat indépendant au regard de l'article 121 du code électoral qui impose 300 signatures. Pour contourner l'obstacle, l'opposant a démissionné du MRC pour adhérer au Manidem. Ce parti dirigé par Anicet Ekane l'a investi candidat à la présidentielle ». Mais une personnalité issue du même parti, Dieudonné Yebga, est venue troubler le jeu, en se présentant candidat également. Et comme un parti ne peut présenter qu'un seul candidat, le Conseil électoral a invalidé les deux candidatures. Incompréhension et indignation au sein de l'opposition… Incompréhension car, souligne Le Journal du Cameroun, « d'autres partis politiques ont investi deux candidats. Et l'un des deux a été accepté. Exemple, au RDPC, parti présidentiel, le président Paul Biya a été accepté contre Léon Theiller Onana, rejeté. Et, autre exemple, au parti UNIVERS, Akere Muna a été accepté tandis que Chantale Adélaïde Membouet a été rejetée ». Et pour sa part, Anicet Ekane, le président du Manidem s'indigne… Dans une interview exclusive à Jeune Afrique, il affirme détenir des preuves accablantes et annonce déposer un recours devant le Conseil constitutionnel. « Maurice Kamto et le Manidem sont victimes d'une opération mafieuse, déclare-t-il. Nous avons constaté des manipulations grossières. (…) Nous avons des preuves qui démontrent clairement une orchestration politique, avec la complicité du pouvoir ». Une candidature unique de l'opposition ? En tout cas, souligne Afrik.com, « ce rejet de Kamto bouleverse le paysage politique camerounais. Le leader du MRC était perçu comme le principal challenger capable d'inquiéter le régime de Paul Biya. Son éviction affaiblit mécaniquement l'opposition et fragilise toute tentative de front commun. Pourtant, certains acteurs appellent à une coalition. Paul Mahel, conseiller et porte-parole d'Akéré Muna, estime que Kamto, même hors course, peut encore jouer un rôle déterminant en soutenant une candidature unique de l'opposition : “il peut encore peser sur l'issue du scrutin s'il apporte son soutien à une dynamique d'unité“. Mais cette hypothèse reste fragile, relève Afrik.com, tant l'opposition camerounaise peine, depuis des années, à s'unir durablement. Si quelques figures comme Akéré Muna ou Cabral Libii plaident pour une candidature de rassemblement, les ambitions personnelles et les querelles de leadership rendent ce scénario incertain. Maurice Kamto, quant à lui, n'a pas encore publiquement indiqué s'il soutiendrait un autre candidat en cas de rejet définitif ». En effet, insiste Le Pays à Ouagadougou, « n'ayant plus rien à perdre, Maurice Kamto pourrait sonner le rassemblement de tous les candidats de l'opposition (…). Mais, est-il seulement capable de ce supplément d'âme ? Pas si sûr, surtout quand on sait qu'en politique et au Cameroun surtout, chacun préfère être tête de rat que queue d'éléphant ? » Indéboulonnable… Et on revient au Point Afrique qui note qu' « au milieu de ce tohu-bohu, Paul Biya reste fidèle à son image : distant, impassible, insaisissable. (…) À 92 ans, celui qui dirige le Cameroun depuis plus de quatre décennies pourrait battre un nouveau record mondial de longévité au pouvoir. Invisible depuis plusieurs mois, son état de santé continue d'alimenter les spéculations. Dans les rangs du régime, nul besoin de programme ni de bilan. Seule la “stabilité“ est érigée en argument. Cameroon Tribune, le quotidien officiel, martèle qu'“un Cameroun en paix vaut mieux qu'une alternance risquée“. La rumeur d'un passage de témoin à son fils Franck Biya, jamais confirmée mais jamais démentie, alimente les soupçons de succession dynastique ». Enfin, Le Point Afrique note encore ce commentaire de La Voix du Centre, hebdomadaire de Bafoussam : « on nous offre un culte monarchique à défaut d'un débat démocratique ».
In his weekly clinical update, Dr. Griffin with Vincent Racaniello chat about how flies transmit H5N1 to humans via their feet and milk, the recent pertussis oubreak and measles epidemic before Dr. Griffin discusses monoclonal antibody therapy can enrich for RSV variants before deep diving into recent statistics on RSV, influenza and SARS-CoV-2 infections the Wasterwater Scan dashboard, whether or not the NB.1.8.1 should be included in the fall 2025 vaccines, the effectiveness of Sinopharm's COVID-19 vaccine, where to find PEMGARDA, provides information for Columbia University Irving Medical Center's long COVID treatment center, where to go for answers to your long COVID questions, how mast cell activation can enhance long COVID and contacting your federal government representative to stop the assault on science and biomedical research. Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Flies, ‘milk snatching' among H5N1 transmission contributors in dairy cattle(CIDRAP) H5N1 virus invades the mammary glands of dairy cattle through “mouth-to-teat” transmission (NSR: National Science Review) Mississippi warns of steep increase in pertussis cases (CIDRAP) MSDH Issues Pertussis Alert (Mississippi State Department of Health) Wastewater for measles (WasterWater Scan) Measles cases and outbreaks (CDC Rubeola) Weekly measles and rubella monitoring (Government of Canada) Measles vaccine recommendations from NYP (jpg) Measles (WHO) Get the FACTS about measles (NY State Department of Health) Measles (CDC Measles (Rubeola)) Measles vaccine (CDC Measles (Rubeola)) Presumptive evidence of measles immunity (CDC) Contraindications and precautions to measles vaccination (CDC) Measles (CDC Measles (Rubeola)) Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) Measles Vaccination: Know the Facts (ISDA: Infectious Diseases Society of America) Deaths following vaccination: what does the evidence show (Vaccine) Influenza: Waste water scan for 11 pathogens (WastewaterSCan) US respiratory virus activity (CDC Respiratory Illnesses) Respiratory virus activity levels (CDC Respiratory Illnesses) Weekly surveillance report: clift notes (CDC FluView) FDA-CDC-DOD: 2025-2046 influenza vaccine composition (FDA) RSV: Waste water scan for 11 pathogens (WastewaterSCan) US respiratory virus activity (CDC Respiratory Illnesses) ENFLONSIA: novel drug approvals 2025 (FDA) RSV-Network (CDC Respiratory Syncytial virus Infection) Respiratory Syncytial virus Strain Evolution and Mutations in Western Australia in the Context of Nirsevimab Prophylaxis (OFID) Waste water scan for 11 pathogens (WastewaterSCan) COVID-19 deaths (CDC) Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses) COVID-19 national and regional trends (CDC) COVID-19 variant tracker (CDC) SARS-CoV-2 genomes galore (Nextstrain) Antigenic and Virological Characteristics of SARS-CoV-2 Variant BA.3.2, XFG, and NB.1.8.1 (biRxiV) Real-world Evaluation of the Effectiveness of Sinopharm COVID-19 Vaccine Against Symptomatic COVID-19 in an Omicron-Dominant Setting in Mozambique (CID) Where to get pemgarda (Pemgarda) EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) Infusion center (Prime Fusions) CDC Quarantine guidelines (CDC) NIH COVID-19 treatment guidelines (NIH) Drug interaction checker (University of Liverpool) Paxlovid (Pfizer) Infectious Disease Society guidelines for treatment and management (ID Society) Molnupiravir safety and efficacy (JMV) Convalescent plasma recommendation for immunocompromised (ID Society) What to do when sick with a respiratory virus (CDC) Managing healthcare staffing shortages (CDC) Steroids, dexamethasone at the right time (OFID) Anticoagulation guidelines (hematology.org) Daniel Griffin's evidence based medical practices for long COVID (OFID) Long COVID hotline (Columbia : Columbia University Irving Medical Center) The answers: Long COVID Mast cell activation symptoms are prevalent in Long-COVID (International Journal of Infectious Diseases) Using the Right Criteria for MCAS (Current Allergy and Asthma Reports) Utility of glucagon-like-peptide-1-receptor agonists in mast cell activation syndrome (The American Journal of the Medical Sciences) Reaching out to US house representative Letters read on TWiV 1238 Dr. Griffin's COVID treatment summary (pdf) Timestamps by Jolene Ramsey. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv Content in this podcast should not be construed as medical advice.
Nels and Vincent review research on how neuropeptides influence the behavior of leafcutter ants, and regulate the different caste behaviors such as defenders, leaf foragers, brood care, and fungus farming. Hosts: Nels Elde and Vincent Racaniello Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiEVO Links for this episode Join the MicrobeTV Discord server Neuropeptides and behavior of leaf cutter ants (Cell) Timestamps by Jolene Science Picks Nels – My academic job offer was rescinded. I'll keep going—but U.S. researchers are running out of road Vincent – There's a new acid in our rain — should we be worried? Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twievo@microbe.tv
One of the challenges for developing gene therapies for inherited eye diseases is that a large number of individual mutations to a gene can drive the same disease. That makes conventional gene replacement therapy a difficult approach to treat a large number of patients. Ocugen is developing gene therapies that target master regulators of genetic networks and can work across different mutations. We spoke to Arun Upadhyay, chief scientific officer and head of research and development at Ocugen, about inherited retinal diseases, the company's platform technology that can work across different genetic mutations, and its potential applications beyond the eye. One note before we begin. Since recording this podcast, Ocugen announced that Carisma Therapeutics and Ocugen's subsidiary OrthoCellix, entered into a definitive merger agreement to create a Nasdaq-listed, late clinical stage regenerative cell therapy company focused on orthopedic diseases. That transaction is not discussed in this interview.
Croissance, société, urbanisme, le Vietnam est un pays en pleine mutation. L'économie la plus dynamique d'Asie du Sud-Est, fait figure, avec la Thaïlande, d'anomalie sur les questions LGBT+ dans une région pourtant très conservatrice. L'homosexualité et la transsexualité, vues comme des « maladies » et traitées comme telles dans certains hôpitaux au Vietnam, il y a encore quelques années, ont vu leur image évoluer rapidement, notamment dans les centres urbains. À Hanoï, notre envoyé spécial Nicolas Rocca est parti à la rencontre de certaines figures du mouvement LGBT+.
Did you see the New Mutants? No? Don't worry – that movie sucked! Let's learn about some real mutants – and without the crummy CGI. Join me on our journey through history as we hear some inspirational stories and learn some mind-blowing bodies. Here are people born with mind-blowing mutations. Advertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy
Scientific Sense ® by Gill Eapen: Prof. Trey Ideker is Professor of Medicine, Bioengineering and Computer Science, and former Chief of Genetics, at the University of California San Diego (UCSD). He is also the Director of the Bridge2AI Functional Genomics Data Generation Program and Co-Director of the Cancer Cell Map Initiative. Please subscribe to this channel:https://www.youtube.com/c/ScientificSense?sub_confirmation=1
On this New Movie Monday we return to the dinosaur infested waters of Jurassic Park Rebirth. We discuss how the heart of this franchise may have gone extinct, the pillars that made the original a classic and why they aren't in this movie, and future of these genetic monstrosities. Close your eyes, hear the amazing tones of John Williams and us...and imagine the first time you saw dinosaurs on the big screen. Synopsis: Zora Bennett leads a team of skilled operatives to the most dangerous place on Earth, an island research facility for the original Jurassic Park. Their mission is to secure genetic material from dinosaurs whose DNA can provide life-saving benefits to mankind. As the top-secret expedition becomes more and more risky, they soon make a sinister, shocking discovery that's been hidden from the world for decades. Starring: Scarlett Johansson, Mahershala Ali, Jonathan Bailey Director: Gareth Edwards Help us make our first feature length Messed Up Movie: https://www.indiegogo.com/projects/mr-creamjean-s-hidey-hole-horror-comedy-movie#/ Support the show on the Patreon: https://www.patreon.com/c/messedupmoviespod Watch our newest short film Sugar Tits Now! https://www.youtube.com/watch?v=Sz7leFqqo4g
This week we take the path less traveled into a irradiated nightmare roadtrip in The Hills Have Eyes. We discuss misbehaving dogs becoming your best ally, the family of mutant cannibals, and how we would react in such a sleazy showdown. Stay close to each other, this one gets dark. Synopsis: On the way to California, a family has the misfortune to have their car break down in an area closed to the public, and inhabited by violent savages ready to attack. Starring: Susan Lanier, John Steadman, Dee Wallace, James Whitworth, Michael Berryman Directed by Wes Craven Youtube: https://youtu.be/DpOQEKOEKTA Help us make our first feature length Messed Up Movie: https://www.indiegogo.com/projects/mr-creamjean-s-hidey-hole-horror-comedy-movie#/ Support the show on the Patreon: https://www.patreon.com/c/messedupmoviespod Watch our newest short film Sugar Tits Now! https://www.youtube.com/watch?v=Sz7leFqqo4g
My guest is Dr. Melissa Ilardo, Ph.D., professor of biomedical informatics at the University of Utah. We discuss the interplay between genes and behaviors, including how certain behaviors can improve resilience by changing gene and organ function, as well as natural selection events happening in humans today. We also discuss the immune system–related reasons people find the smells of potential mates attractive—or not. We explore how physical and psychological traits are passed from one generation to the next, and the specific behaviors that can influence gene expression to improve health and performance. Melissa explains her lab's pioneering research on breath-hold training and how activation of the dive reflex through breath holding can significantly improve oxygen availability by changing spleen size and function. We also delve into the medical uses and ethics of gene editing to cure disease in both babies and adults. For those interested in genes and inheritance, human performance, immune system function, and natural selection, this episode illustrates the remarkable interplay between human nature and nurture. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Joovv: https://joovv.com/huberman Eight Sleep: https://eightsleep.com/huberman LMNT: https://drinklmnt.com/huberman Function: https://functionhealth.com/huberman Timestamps 00:00:00 Melissa Ilardo 00:02:35 Nature vs Nurture, Gene Expression, Eye Color 00:07:06 Sponsors: Joovv & Eight Sleep 00:10:24 Epigenetics, Trauma, Mutations; Hybrid Vigor, Mate Attraction 00:15:47 Globalization; Homo Sapiens, Mating & Evolution; Mutations 00:25:28 Sea Nomads, Bajau & Moken Groups; Free Diving, Dangers & Gasp Reflex 00:32:52 Cultural Traditions, Free Diving & Families; Fishing 00:35:36 Mammalian Dive Reflex, Oxygen, Spleen, Cold Water & Face; Exercise 00:42:43 Sponsors: AG1 & LMNT 00:46:00 Free Diving, Spleen, Thyroid Hormone, Performance Enhancement 00:52:00 Dive Reflex, Immune System; Swimming & Health; Coastal Regions & Genetics 00:55:17 Female Free Divers, Haenyeo, Cold Water, Age, Protein 01:03:20 Human Evolution & Diet, Lactase, Fat 01:05:07 Korean Female Free Divers & Adaptations, Cardiovascular, Pregnancy 01:10:13 Miscarriages & Genetic Selection; Bajau, External Appearance, Mate Selection 01:17:15 Sponsor: Function 01:19:03 Free Diving, Underwater Vision; Super-Performers & Genetics 01:25:01 Cognitive Performance, Autism, Creativity; Genetic Determinism & Mindset 01:36:30 Genetics & Ethics, CRISPR, Embryo Genetic Screening 01:44:36 Admixture, Genetics; Are Humans a Single Species? 01:49:39 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, Sponsors, YouTube Feedback, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices
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