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This week, Professor Jan Vijg joins us to discuss the intricate relationship between DNA mutations, epigenetic drift, and aging. He explains the differences between mutations and epigenetic changes, the role of environmental factors, and the potential for reversing epigenetic changes. The conversation also touches on the implications of somatic mutations and the future of longevity research, particularly in relation to DNA repair mechanisms. Learn more about Professor Jan Vijg: https://einsteinmed.edu/faculty/11318/jan-vijg - Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0 Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com
durée : 00:04:22 - Le Reportage de la rédaction - En 2005, trois semaines de violences embrasent la France. À l'époque, les habitants des quartiers se mobilisent pour tenter d'apaiser la situation. Une démarche politique, mais vingt ans plus tard, que reste-t-il de cet engagement citoyen dans les quartiers populaires ?
In this bright and refreshing episode, Janina travels to the shores of Lake Garda to uncover one of Italy's most exciting and underrated white wine regions - Lugana DOC. Her guest is Fabio Zenato, president of the Consorzio Tutela Lugana DOC, who brings three generations of family knowledge and a deep passion for the local Turbiana grape. Together, they explore the true identity of Turbiana, the unique glacial soils of the region, and why Lugana wines can age far beyond expectations. Expect insights into clonal selection, microclimate, and terroir - all wrapped in stories of tradition, elegance, and discovery. Shownotes [01:53] Third-generation vintner Fabio Zenato reflects on childhood memories that shaped his connection to the vineyards of Lugana. [02:28] Family heritage and early experiences that inspired a lifelong dedication to the land and its vines. [04:46] Clarifying the genetic confusion surrounding the Turbiana grape and its historical misidentification. [04:57] Understanding the DNA difference between Turbiana, Verdicchio, and Trebbiano di Soave. [09:18] Mutation or clone — exploring how proximity to Soave influenced Turbiana's evolution. [10:41] Labeling inconsistencies and the importance of protecting the Turbiana name. [12:04] Tasting Tommasi Le Fornaci 2024 (£19.99 Cambridge Wine Merchants) and what to expect from a fresh, mineral-driven Lugana wine. [14:40] Locating Lugana: the southern shores of Lake Garda, between Lombardy and Veneto. [19:27] The influence of Lake Garda's breezes and surrounding topography on vineyard climate. [20:33] The role of elevation - from 60 to 100 meters - and how slight altitude differences affect freshness and balance. [22:02] Exploring Monte Lupo 2015 from Cobue and understanding why Turbiana has remarkable aging potential. [24:47] How Lugana wines maintain acidity and evolve with nutty, floral, and mineral complexity over time. [27:40] Introducing La Rifra Riserva 2022 - structure, richness, and longevity in the glass. £24.99 D Vino Wines [28:53] Defining what makes a Lugana Riserva: minimum aging, depth, and stylistic differences. [32:53] The story behind Benedictus 2023 from Le Morette — the philosophy and inspiration behind its name. £22 The Wine Rack [34:41] Winemaking approach: lees aging, oak influence, and the balance between richness and minerality. [38:05] Food pairing ideas — from seafood to risotto, and how Lugana's texture makes it versatile. [40:05] Tasting Feliciana 'Serce' Riserva 2022 — €27.95 Woodberrys.ie [40:36] Travel tips: flying into Verona for the easiest route to Lugana and Lake Garda. [42:59] Must-try local dishes and regional specialties to pair with Turbiana wines. [45:28] A new generation of winemakers bringing innovation through sparkling and sweet styles. [46:50] Corte Sermana Duerive 2023 — bright, delicate, and grown by the lake, where the vines feel the breeze off Garda's shores. [49:07] The perfect Lugana moment — sunshine, lake views, and a chilled glass of Turbiana.
durée : 00:01:24 - Le Reportage de la rédaction - Il y a vingt ans, Zyed et Bouna, deux adolescents de Clichy-sous-Bois mourraient lors d'une course poursuite avec des policiers. Ce drame avait provoqué la colère des jeunes des quartiers populaires et 3 semaines de violences, dans près de 300 villes de France. Cette colère n'a pas disparu.
durée : 00:04:22 - Le Reportage de la rédaction - En 2005, trois semaines de violences embrasent la France. À l'époque, les habitants des quartiers se mobilisent pour tenter d'apaiser la situation. Une démarche politique mais vingt ans plus tard, que reste-t-il de cet engagement citoyen dans les quartiers populaires ?
Nous sommes en octobre.Partout en France, le rose s'affiche sur les façades, les affiches, les vêtements.Il symbolise la lutte, la solidarité, l'espoir.Ce soir, à la mairie du 3ᵉ arrondissement de Paris, ce message prend une autre forme : il se danse.Dans les coulisses, quatre femmes se préparent.Les rires se mêlent aux gestes du trac.On ajuste une robe, on vérifie une mèche, on respire.Sur scène, elles danseront avec leur professeure Aurélie Lili Boo, au sein de l'association Elles dansent, fondée par Aude Michon.Une association qui accompagne, à travers la danse, des femmes touchées par le cancer.Ici, pas de miroir pour juger.Pas de quête de perfection.Seulement des corps qui se réapprivoisent, des visages qui se relèvent,des gestes qui reprennent confiance.J'ai posé mon micro dans les coulisses, au plus près de leurs voix, de leurs rires, de leurs silences aussi.Ensemble, nous avons partagé ce moment suspendu où la vie, pour un instant, reprend le dessus.Muriel, Sylvia, Régine et Emmanuelle racontent leur rapport au corps, à la féminité, à la maladie, mais surtout à la joie d'être ensemble.Dans chaque mouvement, il y a une victoire intime.Ce reportage est une traversée — de la fatigue à la lumière, de la peur à la fierté, du corps contraint au corps dansant.Une parenthèse pour célébrer la force tranquille de celles qui continuent d'avancer.—
Der Ausbruch der Vogelgrippe trifft in Deutschland vor allem Kraniche. Grund könnte eine fehlende Herdenimmunität für eine besondere Mutation des H5N1-Viruses sein. Doch auch andere Vögel sind betroffen. Menschen sollten ebenfalls vorsichtig sein. Brose, Maximilian www.deutschlandfunk.de, Forschung aktuell
« Gender reveal », « professional baby namer », « funeral planner »… Entre nouveaux métiers et évènements taillés surmesure pour les réseaux sociaux, les Etats-Unis s'imposent comme le laboratoire des tendances les plus étonnantes, voire les plus absurdes, dans la mise en scène et la commercialisation des moments de vie. Mention légales : Vos données de connexion, dont votre adresse IP, sont traités par Radio Classique, responsable de traitement, sur la base de son intérêt légitime, par l'intermédiaire de son sous-traitant Ausha, à des fins de réalisation de statistiques agréées et de lutte contre la fraude. Ces données sont supprimées en temps réel pour la finalité statistique et sous cinq mois à compter de la collecte à des fins de lutte contre la fraude. Pour plus d'informations sur les traitements réalisés par Radio Classique et exercer vos droits, consultez notre Politique de confidentialité.Hébergé par Ausha. Visitez ausha.co/politique-de-confidentialite pour plus d'informations.
Join The Deep Dive(Life-changing teachings for spiritual mastery, guided sound journeys, and access to live community gatherings to share your most authentic self) https://iamemilioortiz.com/the-deep-d...In this visionary interview, Richard Rudd — creator of the Gene Keys — joins Emilio Ortiz to explore one of the most profound themes in human evolution: the path of love, commitment, and transformation. Together they dive deep into Gene Key 29, which emphasizes the importance of surrendering to the heart's journey, even when faced with uncertainty. This dialogue weaves together the mysteries of DNA mutations, collective healing, and Gaia's awakening, offering a rare glimpse into the birth of the future human. Beyond the teachings of the Gene Keys, Emilio and Richard reflect on the contrasts between the creative process and AI, highlighting how technology can accelerate output but often lacks the depth of authentic human creativity. This episode illuminates the possibilities of a coming epoch where Gaia and humanity evolve together, where DNA mutations may spark new potentials, and where each of us is invited to become a living expression of infinity, wisdom, and awakening.Over the past several decades, Richard has dedicated his life to unraveling the mysteries of human consciousness and evolution, and from his initial download at 29, has developed a unique and transformative system for unlocking human potential using the power of the Gene Keys. Through his books, workshops, and online courses, Richard has helped countless individuals around the world to awaken to their true potential and discover their life's purpose. The Gene Keys is a system of spiritual and personal growth that draws on a variety of wisdom traditions, including astrology, human design, the I Ching, and the Kabbalah. At its core, the Gene Keys is a map of human consciousness that helps individuals to unlock their highest potential and transcend the limitations of their past conditioning. Join Richard Rudd for his upcoming London event (2025)
Bienvenue dans Un pas de côté, une capsule du podcast Les Sens de la Danse imaginée par Myriam Sellam pour éclairer chaque épisode.Chaque dimanche, une voix, une histoire, un parcours intime. Et parfois, pour mieux comprendre ce qui se joue entre les mots, il suffit de faire… un pas de côté.Cette fois, on prolonge la rencontre avec Claire Francisci-Ducret, danseuse durant 6 années au Crazy Horse Paris — ce cabaret mythique qui a fait du corps féminin un langage à part entière.Car pour saisir la portée de son parcours, il faut aussi comprendre le lieu qui l'a façonnée.Le Crazy Horse n'est pas un cabaret comme les autres.Fondé en 1951 par Alain Bernardin, il est né d'une fascination pour la beauté, la lumière et la perfection du geste. Ici, pas de strass criards ni de froufrous tapageurs : tout est question d'angle, de ligne, de précision.Les danseuses — les célèbres Crazy Girls — ne sont pas seulement des interprètes : ce sont des instruments de lumière, des sculptures vivantes. Leurs corps deviennent toiles, leurs mouvements, calligraphies.Derrière cette esthétique millimétrée, il y a une véritable chorégraphie du regard.L'art du Crazy Horse, c'est celui de la suggestion, du mystère, de la géométrie sensuelle. Un univers où l'érotisme se fait stylisé, abstrait, presque conceptuel.Et pourtant, derrière le fantasme, se cache une discipline de fer : répétitions, rigueur, synchronisation parfaite. Les shows du Crazy sont le fruit d'une exigence rare, héritée du ballet et du music-hall.En revisitant ce lieu à travers l'histoire et l'esthétique, cette capsule interroge :
In this episode we connect genetics + central dogma to the next big step: how cells copy DNA and what happens when it goes wrong.What you'll learn (MCAT-high yield):Semi-conservative replication: why each daughter DNA has one old + one new strandOrigins of replication & replication bubblesKey enzymes: helicase, SSB proteins, topoisomerase, DNA pol III & I, primase, ligaseLeading vs. lagging strands and Okazaki fragmentsProofreading & repair: exonuclease activity, mismatch repair, nucleotide excision repair (UV/thymine dimers)Mutation types: silent, nonsense, frameshift (+ why location matters)Where this shows up in cell cycle, cancer biology, and classic experimental set-ups (knockouts)Perfect for MCAT Bio/Biochem passages that love replication, mutations, and repair pathways.Want to learn more? Shoot us a text at 415-855-4435 or email us at podcast@jackwestin.com!
Aujourd'hui, Didier Giraud, éleveur de bovins, Charles Consigny, avocat, et Flora Ghebali, entrepreneure dans la transition écologique, débattent de l'actualité autour d'Alain Marschall et Olivier Truchot.
Sous les lumières du Crazy Horse, elle a dansé la rigueur, la précision, la beauté géométrique du geste.Sur la barre verticale de la pole dance, elle a trouvé la liberté, la force, la reconquête du corps.Dans cet épisode, Claire Francisci-Ducret, danseuse, chorégraphe et fondatrice de Pole Spirit Paris, revient sur un parcours aussi exigeant qu'inspirant — de ses débuts au Conservatoire d'Avignon à la scène mythique du Crazy Horse, jusqu'à la création de sa propre école à Paris.Pendant six ans, elle a dansé au Crazy Horse, temple de la lumière et de la discipline, où chaque mouvement se mesure au millimètre près.Aujourd'hui, elle enseigne la pole dance comme un art du courage et du dépassement, un espace où le corps se libère des normes, où la puissance et la douceur se rencontrent.Dans cette conversation enregistrée au sein de son école, Claire nous parle de :– rigueur et sensualité,– confiance en soi et dépassement,– beauté du geste et puissance intérieure,– mais aussi de cette liberté que seule la danse peut offrir.Elle raconte comment elle a su transformer la discipline en art, et l'exigence en élan de vie.
Host: Charles Turck, PharmD, BCPS, BCCCP Guest: Sarah Sammons, MD About 40 percent of patients with metastatic HR+/HER2- breast cancer have an activating mutation in the PIK3CA gene,1,2 which plays a key role not only in tumor growth, but also in driving resistance to endocrine therapy.3-5 And while there are several FDA-approved PI3K pathway-targeted agents for patients with PIK3CA tumor mutations,6-8 they come with challenges, like modest efficacy and on-pathway effects.9-12 Given this unmet need, the ReDiscover trial evaluated the investigational agent RLY-2608 in combination with fulvestrant in in patients with PIK3CA-mutated HR+/HER2- aBC previously treated with a CDK4/6 inhibitor.13 Joining Dr. Charles Turck to share updated safety and efficacy data from the trial is Dr. Sarah Sammons, a Senior Physician at the Dana-Farber Cancer Institute and an Assistant Professor of Medicine at Harvard Medical School in Boston. References: Vasan N, Cantley LC, Vasan N, Cantley LC. At a crossroads: how to translate the roles of PI3K in oncogenic and metabolic signalling into improvements in cancer therapy. Nat Rev Clin Oncol. 2022;19(7):471-485. doi:10.1038/s41571-022-00633-1 Network TCGA. Comprehensive molecular portraits of human breast tumours. Nature. 2012;490(7418):61-70. doi:10.1038/nature11412 Saal LH, Johansson P, Holm K, et al. Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor …
Avant d'être une icône mondiale, le hamburger était un sandwich de rue. Né il y a plus de 135 ans aux États-Unis, ce sandwich simple en apparence raconte une histoire bien plus complexe : celle de la mondialisation et des mutations de nos habitudes alimentaires. Plaisir coupable pour les uns, fétiche réinventé pour les autres, le burger unit toutes les générations et dit beaucoup de nos sociétés. Yasmine Boudaka évoque l'histoire d'un des symboles culinaires américains avec Pierre Leclercq, historien de l'alimentation et auteur du Petit traité du burger, paru aux Éditions du Sureau. Sujets traités : burger, sandwich, États-Unis, mondialisation , mutations, Merci pour votre écoute Un Jour dans l'Histoire, c'est également en direct tous les jours de la semaine de 13h15 à 14h30 sur www.rtbf.be/lapremiere Retrouvez tous les épisodes d'Un Jour dans l'Histoire sur notre plateforme Auvio.be :https://auvio.rtbf.be/emission/5936 Intéressés par l'histoire ? Vous pourriez également aimer nos autres podcasts : L'Histoire Continue: https://audmns.com/kSbpELwL'heure H : https://audmns.com/YagLLiKEt sa version à écouter en famille : La Mini Heure H https://audmns.com/YagLLiKAinsi que nos séries historiques :Chili, le Pays de mes Histoires : https://audmns.com/XHbnevhD-Day : https://audmns.com/JWRdPYIJoséphine Baker : https://audmns.com/wCfhoEwLa folle histoire de l'aviation : https://audmns.com/xAWjyWCLes Jeux Olympiques, l'étonnant miroir de notre Histoire : https://audmns.com/ZEIihzZMarguerite, la Voix d'une Résistante : https://audmns.com/zFDehnENapoléon, le crépuscule de l'Aigle : https://audmns.com/DcdnIUnUn Jour dans le Sport : https://audmns.com/xXlkHMHSous le sable des Pyramides : https://audmns.com/rXfVppvN'oubliez pas de vous y abonner pour ne rien manquer.Et si vous avez apprécié ce podcast, n'hésitez pas à nous donner des étoiles ou des commentaires, cela nous aide à le faire connaître plus largement. Hébergé par Audiomeans. Visitez audiomeans.fr/politique-de-confidentialite pour plus d'informations.
Et si danser, c'était se nettoyer ?Pas seulement transpirer ou se défouler,mais vraiment se libérer de ce qui encombre : les pensées, les émotions, les tensions accumulées.Dans cette capsule d'Un pas de côté, Myriam Sellam explore une idée évoquée par Aurélia Monaco :celle de la danse comme hygiène émotionnelle.Un geste simple, instinctif, que l'on retrouve dans toutes les cultures du monde — et qui relie le mouvement à la santé de l'âme.Des derviches soufis aux danses africaines rituelles,du Butô japonais né des cendres d'Hiroshimaà la grâce libre d'Isadora Duncan et aux recherches de Rudolf Laban ou Mary Wigman,la danse a toujours été un moyen de traverser, de transformer, d'apaiser.Avant d'être un art, elle fut un soin.Un rituel de rééquilibrage du corps et de l'esprit.Un espace où l'on remet de la vie là où tout semble figé.Aujourd'hui encore, la danse garde ce pouvoir :celui de libérer, d'alléger, de remettre en mouvement ce qui, en nous, s'est refermé.Pas besoin d'être danseur ou danseuse pour en faire l'expérience :il suffit d'un pas, d'un souffle, d'un geste.Dans un monde saturé de bruit et d'obligations, danser devient un acte d'hygiène intérieure.Un retour à soi.Une manière douce de se vider du trop-plein pour laisser la place à la clarté, à la joie, à la présence.Un pas de côté propose ici une réflexion poétique et accessible sur ce lien essentiel entre le corps, les émotions et le mouvement.Une invitation à penser la danse autrement : non plus comme une discipline,mais comme un espace de respiration, de soin et de résonance.
Nels and Vincent discuss research which shows a shift from the rule that living organisms produce same-species offspring: an ant that produces individuals from two distinct species. Hosts: Nels Elde and Vincent Racaniello Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiEVO Links for this episode Join the MicrobeTV Discord server David Baltimore interview (TWiV 100) One mother for two species (Nature) Timestamps by Jolene Science Picks Nels – Dr. Bill Rom, NYU canoes every lake connected by a portage trail in the Boundary Waters in Minnesota Vincent – Google just made photography obsolete Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twievo@microbe.tv
This YT is now @CosmicBrewPodcast. The prior YT channel with older episodes - which is no longer collective astrology focused (is @alignedgold). The brand (formally @successandspirit is now @alignedgold)***1️⃣) My evolutionary shift work (quantum meets evolutionary astrology) will release in November. This link provides you taste of what I do and my results:***2️⃣) My Clarity by Design Sessions: (Human Design informed life/business strategy) ⬇️This is the link in case the arcane podcast "notes formatting": doesn't work: https://cal.com/alignedgold/clientsession***3️⃣) My 1-1 business strategy work is booked through 2025. I will open up slots in 2026. I will notify my email list first. Snakes, butterflies, Channel of Mutation, Why everyone is so weird right now, Kali, Karma, Saturn, Life Path 8, Taking Power in the World, MoneyThread Post Mentioned Link:In this fiery episode of Cosmic Brew: The Astrology of Power, Cycles, and Collective Evolution, Sunita dives straight into the raw conversation on power, money, and feminine archetypes—no filters, no fluff.Venus may have crossed into Libra, but it's Pluto and Kali who take center stage. From Saturn's karmic lessons to the shadow side of the spiritual industry, Sunita unpacks the difference between embodying the divine and serving it.Expect sharp riffs on:Why Kali isn't a brand persona—and what happens when people treat Her like oneThe difference between consequence and karma (and how Western culture gets it wrong)How Saturn and Pluto define modern power—and why women mastering the material plane is a spiritual actSnakes, shedding, and butterflies as metaphors for our collective transformationThe next six months of energetic recalibration as we approach the final Human Design New Year before the Cross of the Sleeping PhoenixPlus, Sunita shares a behind-the-scenes story from Threads that proves why you don't mess with The Goddess.
Les métiers de la transition écologique ou du numérique sont en train de se développer, le télétravail est entré dans les mœurs, la féminisation de certains secteurs est un enjeu crucial… Dans ce grand entretien, Arnaud Brun, président du conseil de surveillance d'Adéquat, explique comment l'intérim s'adapte à ces mutations. ----------------------------------------------------------------------- SMART IMPACT - Le magazine de l'économie durable et responsable SMART IMPACT, votre émission dédiée à la RSE et à la transition écologique des entreprises. Découvrez des actions inspirantes, des solutions innovantes et rencontrez les leaders du changement.
Ein Standpunkt von Felix Feistel.Seit der vermeintlichen Corona-Pandemie wird medial und politisch die Erzählung kolportiert, dass eine weitere Pandemie nur eine Frage der Zeit sei. Jederzeit könne ein anderer Erreger aus dem Tierreich auf den Menschen überspringen und sich dann um die Welt verbreiten. Daher werden Pandemieübungen abgehalten, forscht die Wissenschaft unter Hochdruck an Erregern in Laboren, und aus diesem Grunde wurde in der WHO auch ein Pandemievertrag beschlossen, der, zusammen mit den Reformen der Internationalen Gesundheitsverordnungen (IGV), der WHO weitreichende Befugnisse einräumt. Künftig soll schon die Gefahr einer Pandemie genügen, um einschneidende Maßnahmen zu verhängen, wie wir sie aus der Coronasimulation kennen – auch, wenn diese nach wie vor keinen erwiesenen Nutzen haben. Dank digitaler Technokratie, die digitale Zentralbankenwährung ebenso enthält wie digitaler Identität, digitalem Impfpass und vollumfänglicher Überwachung kann die nächste Impfung jedem Menschen aufgezwungen werden – unter Androhung des Verlustes des Zugangs zum eigenen Bankkonto beispielsweise.Und die Vorbereitungen für eine solche Pandemie laufen auf Hochtouren. Schon seit Jahren wird etwa immer wieder die Vogelgrippe als potenzieller Erreger für eine Pandemie eingestuft. Diese, so sagen die sogenannten Experten, habe das Potenzial noch viel tödlicher zu sein als Corona. In der öffentlichen Erzählung handelte es sich bei Corona um eine todbringende Super-Seuche, und nur diese Wahrnehmung zählt für diesen Vergleich. So wird regelmäßig Panik geschürt, wenn irgendwo die Vogelgrippe nachgewiesen wird. (1)Denn diese Krankheit habe, so die Erzählung, eine Todesrate von 60 Prozent. Damit würden 60 Prozent der infizierten Menschen sterben. Diese Zahl ist jedoch seriöser Wissenschaft zufolge deutlich übertrieben. Tatsächlich liegt die Todesrate weit darunter. Sie wird eher bei 14 bis 33 Prozent eingestuft – was jedoch immer noch recht hoch ist. Allerdings muss hier ein Gefälle zwischen entwickelten Industrieländern und unterentwickelten Ländern berücksichtigt werden. Rechnet man das mit ein, dann zeichnet sich für entwickelte Länder eine Letalität von 1,85 Prozent ab – maximal. Das jedoch nur, wenn der Erreger tatsächlich auf den Menschen überspringt, was jedoch sehr unwahrscheinlich ist. So sind in der ersten Hälfte des Jahres 2025 laut WHO weltweit gerade einmal 5 Menschen mit der Vogelgrippe infiziert worden – zumindest vermeintlich. Von diesen 5 seien dann 3 gestorben – was tatsächlich ein hoher Anteil ist - jedoch ist die Wahrscheinlichkeit, sich zu infizieren, minimal.Auch die Berichte aus dem vergangenen Jahr, nachdem die Vogelgrippe auf Milchkühe übergesprungen sei und dann auch Milchbauern infiziert habe, entpuppte sich bei genauerem Hinsehen als vollkommen falsch. So falsch, wie wahrscheinlich die gesamte Erzählung der Vogelgrippe ist. Denn bei der Vogelgrippe – klassischerweise H5N1 – handelt es sich um einen Erreger, der selbst den offiziellen Handbüchern der Weltorganisation für Tiergesundheit (WOAH) oder dem in Deutschland für Tiersuchen zuständigen Friedrich Löffler Institut (FLI) zufolge, für die Vögel zunächst harmlos ist. Unterschieden wird dabei zwischen „niedrigpathogener“ und „hochpathogener“ Vogelgrippe. Die ganze Angst vor der Vogelgrippe basiert nun auf der Annahme, dass die zunächst niedrigpathogene H5N1-Vogelgrippe sich durch eine „spontane Mutation“ zu einer hochpathogenen Variante entwickeln könnte. Welche Mechanismen diese Mutation bewirken sollen, wie die Mutation vonstatten geht und was genau eigentlich dafür mutieren muss, all das wurde nie näher beschrieben und wird auch nicht erforscht. Das Friedrich Löffler Institut (FLI) stellt diese Behauptung einfach in den Raum – und alle halten sie für wahr....https://apolut.net/simulierte-seuchen-von-felix-feistel/ Hosted on Acast. See acast.com/privacy for more information.
On this week's episode, Josh and Michael exchange the established treatment landscape of EGFR and ALK mutant NSCLC for the developing management of disease harbouring KRAS and MET mutations. The most common mutation meets one of the least common in this battle of therapeutic tenacity.Studies discussed in this episode:INSIGHT-2KRYSTAL-12For more episodes, resources and blog posts, visit www.inquisitiveonc.comPlease find us on Twitter @InquisitiveOnc!If you want us to look at a specific trial or subject, email us at inquisitiveonc@gmail.comArt courtesy of Taryn SilverMusic courtesy of AlisiaBeats: https://pixabay.com/users/alisiabeats-39461785/Disclaimer: This podcast is for educational purposes only. If you are unwell, seek medical advice.Oncology for the Inquisitive Mind is recorded with the support of education grants from our foundation partners Pfizer, Gilead Pharmaceuticals and Merck Pharmaceuticals. Our partners have access to the episode at the same time you do and have no editorial control over the content. Hosted on Acast. See acast.com/privacy for more information.
Longtemps, a cherché à bien faire. À cocher toutes les cases.Avocate fiscaliste dans un grand cabinet parisien, elle vivait dans un monde où tout devait être maîtrisé, planifié, prouvé.Une vie brillante, mais où la tête prenait toute la place.Jusqu'au jour où son corps a dit stop.Fatigue, perte de sens, surcharge émotionnelle : il n'y avait plus d'air.Ce jour-là, Aurélia comprend qu'elle ne peut plus continuer à s'éloigner d'elle-même.Ce qu'elle ressent trop fort, ce qu'elle croyait devoir cacher, est en réalité sa plus grande force : son hypersensibilité.Alors elle quitte le droit, sans plan B.Et se met à reconstruire sa vie, pas à pas.Par l'écoute, par l'écriture, par le mouvement.Aujourd'hui, Aurélia Monaco accompagne les personnes hypersensibles à retrouver leur équilibre.Elle les aide à transformer cette intensité en puissance d'action, à se reconnecter à leurs émotions, à leur intuition et à leur joie.Son approche est globale : le corps, la parole, l'image, la respiration…Et surtout, la danse. Car Aurélia enseigne l'Afrovibe, une danse joyeuse, libre et profondément ancrée, qui invite à lâcher le mental pour revenir au corps.Une danse sans jugement, sans performance, où l'on bouge pour se sentir vivant.Un espace où tout peut circuler — les rires, les larmes, la fatigue, la joie.Une véritable hygiène émotionnelle, comme elle aime le dire.Elle est aussi l'autrice du livre J'assume mon hypersensibilité (et je retrouve ma liberté !), publié aux éditions Gereso.Un ouvrage qui réconcilie le lecteur avec sa sensibilité, et l'invite à en faire une boussole plutôt qu'un fardeau.Dans cet épisode, Aurélia revient sur ce grand basculement :le moment où tout a vacillé, ses premiers cours en talons, la découverte du collectif, et la joie de danser sans chercher à bien faire.Une conversation lumineuse et sincère, où l'on parle de vulnérabilité, d'énergie, et de ce lien mystérieux entre mouvement et liberté.
This YT is now @CosmicBrewPodcast. The prior YT channel with older episodes - which is no longer collective astrology focused (is @alignedgold). The brand (formally @successandspirit is now @alignedgold)***1️⃣) My evolutionary shift work (quantum meets evolutionary astrology) will release in November. This link provides you taste of what I do and my results:***2️⃣) My Clarity by Design Sessions: (Human Design informed life/business strategy) ⬇️This is the link in case the arcane podcast "notes formatting": doesn't work: https://cal.com/alignedgold/clientsession***3️⃣) My 1-1 business strategy work is booked through 2025. I will open up slots in 2026. I will notify my email list first. Can you feel the shift? In this raw, real-time reflection recorded on the powerful mirror day 10/10, Sunita unpacks the energetic pivot that marks the end of Pluto's long stay in Gate 60 — and the close of an era of mutation, intensity, and deep internal rewiring.She explores:Why manifestation is accelerating as Uranus moves toward GeminiHow Pluto's station direct triggers an unveiling — the literal meaning of “apocalypse”The difference between Pluto's feminine felt power and Mars' performative fireThe collective integration phase following years of upheavalHow to detox your mind and environment during high-frequency transitsWhy words, rituals, and intention-setting hold amplified power under Mercury in Scorpio and a Virgo MoonThis episode closes the loop on a four-year cycle that began with Cosmic Alarm Clock and sets the tone for what's ahead — a more elegant, distilled Cosmic Brew for the Uranus-in-Gemini era.☕️ Expect truth-telling, catalytic clarity, and insight on how to navigate the final stretch of Gate 60 before everything accelerates.Doing Gemini in Business YoutTube: https://www.youtube.com/watch?v=72eTRd3SsXc&t=64sAlso check out the links below showcasing key milestones in the evolution of this brand — the Rosetta Stone moments that shaped its birth and growth.IG Live Virgo Full Moon 3/2022. Birth of Cosmic Alarm Clock: https://www.instagram.com/tv/CbNtrVyBDZ1/?igsh=c3oyd2x2aHY3eGRjLaunch of the Brand on 8/8/21 on IG:https://www.instagram.com/p/CST6aMmLqEz/?igsh=MTExcTV6anh0cTZkZw==Snake Photo on 11/11/21 on IG:https://www.instagram.com/p/CWmLxLILUzs/?igsh=MTZiNW5ldmZncGJlcQ==Keywords:Pluto Direct 2025, Manifestation in Human Design, Cosmic Brew PodcastExplore Pluto's 2025 station, Uranus in Gemini, and real-world manifestation through Human Design and collective awakening.Pluto Direct 2025, Human Design Gate 60, Uranus in Gemini, manifestation, collective awakening, cosmic shifts, astrology podcast, spiritual transformation, Sunita Kumar, Cosmic Brew
This YT is now @CosmicBrewPodcast. The prior YT channel with older episodes - which is no longer collective astrology focused (is @alignedgold). The brand (formally @successandspirit is now @alignedgold)***1️⃣) My evolutionary shift work (quantum meets evolutionary astrology) will release in November. This link provides you taste of what I do and my results:***2️⃣) My Clarity by Design Sessions: (Human Design informed life/business strategy) ⬇️This is the link in case the arcane podcast "notes formatting": doesn't work: https://cal.com/alignedgold/clientsession***3️⃣) My 1-1 business strategy work is booked through 2025. I will open up slots in 2026. I will notify my email list first. Aries Fire: Misunderstood Pioneers and the Courage to Move Humanity ForwardEvery revolutionary was misunderstood first. Emerson knew it. So did Galileo, Copernicus, and every soul who dared to move humanity forward.In this fiery Aries Full Moon transmission, Sunita channels the spirit of the misunderstood pioneer — the one who climbs before there's a path, speaks before there's consensus, and leads before the world catches up.You'll hear:Why being misunderstood is a hallmark of trailblazers and innovatorsWhat Aries reveals about courage, leadership, and risk-takingHow Neptune's rare movement into Aries sets the tone for a new collective eraThe deeper cycles behind the Sun–Mars conjunctions and Pluto's final pass through Gate 60How the masculine and feminine archetypes are being rewritten in real timeWhy this eclipse season represents — the completion of one evolution and the seeding of the nextSunita also reflects on legacy, receipts, and Saturn's demand for record-keeping — why visibility now isn't about vanity metrics, but about marking the truth in real time.☕️ A potent brew of astrology, history, and unapologetic Aries fire.Aries Full Moon 2025 | Misunderstood Pioneers, Mars in Scorpio & Collective CourageExplore the Aries Full Moon, Mars in Scorpio, and why being misunderstood marks true pioneers in this fiery Cosmic Brew episode.Tags / Keywords:Aries Full Moon, Mars in Scorpio, Pluto Gate 60, Uranus in Gemini, misunderstood pioneers, Human Design, astrology podcast, cosmic awakening, eclipse season, feminine rising, Sunita Kumar, Cosmic Brew, Aries Full Moon, Full Moon in Aries, Neptune in Aries, eclipse season, Mars conjunction, Pluto in Aquarius, astrology, human design, Channel of Mutation, 2026 predictions, Saturn astrology, collective evolution, Saturn in Pisces, Saturn in Aries, Uranus in Gemini, Virgo Eclipse, Pisces Eclipse
Bienvenue dans Un pas de côté, une capsule des Sens de la Danse pour éclairer chaque épisode.Parce que pour comprendre les mots des artistes, il faut parfois revenir aux origines des œuvres qu'ils interprètent.Aujourd'hui, je vous emmène à la rencontre de Giselle , le chef-d'œuvre du ballet romantique créé à Paris en 1841.Un ballet né du génie du compositeur Adolphe Adam, chorégraphié par Jean Coralli et Jules Perrot, sur un livret inspiré d'une légende racontée par le poète romantique Heinrich Heine.L'histoire est connue, mais sa puissance reste intacte. Giselle, jeune paysanne amoureuse d'un homme qu'elle croit villageois, découvre qu'il s'agit du comte Albrecht , déjà fiancé à une autre.Brisée par la trahison, elle sombre dans la folie et meurt.Au deuxième acte, elle rejoint les Wilis, ces esprits vengeurs de jeunes fiancées mortes avant leur mariage.Mais au lieu de condamner Albrecht, elle le sauve — dans un ultime geste d'amour et de pardon.Ce ballet, créé pour la danseuse Carlotta Grisi et resté depuis au répertoire de l'Opéra de Paris, incarne toute l'essence du romantisme : la passion, la mort, la rédemption.Il a traversé les époques, interprété par les plus grandes étoiles — de Yvette Chauviré à Aurélie Dupont, de Sylvie Guillem à Myriam Ould-Braham —, et continue d'émouvoir des générations entières.Mais Giselle n'est pas seulement un drame d'amour : c'est aussi un miroir de notre humanité.Chaque version, chaque interprète, redonne vie à ce récit universel : celui de l'amour qui survit à la mort, de la douceur qui triomphe de la violence, et du corps qui devient le messager de l'âme.Pour un danseur comme Andrea Sarri, qui interprète aujourd'hui Albrecht à l'Opéra Garnier, Giselle est un rôle d'équilibre : entre la force et la fragilité, entre le contrôle et l'abandon.Un rôle qui, à chaque représentation, prend une nouvelle couleur, une nouvelle profondeur.Près de deux siècles après sa création, Giselle demeure l'un des ballets les plus dansés au monde.Et si son histoire nous bouleverse encore, c'est peut-être parce qu'elle nous parle de ce que nous sommes : des êtres capables de tomber, de trahir, de regretter, mais aussi d'aimer au-delà de tout.
In this episode, Michael and Josh take a dive into the world of driver mutations, looking at two of the most clinically consequential: EGFR and ALK mutations. The work done in these areas has led to treatments that represent incredible advances over chemotherapy. How incredible? You'll just have to listen and find out.Studies discussed in this episode:MARIPOSACROWNFor more episodes, resources and blog posts, visit www.inquisitiveonc.comPlease find us on Twitter @InquisitiveOnc!If you want us to look at a specific trial or subject, email us at inquisitiveonc@gmail.comArt courtesy of Taryn SilverMusic courtesy of AlisiaBeats: https://pixabay.com/users/alisiabeats-39461785/Disclaimer: This podcast is for educational purposes only. If you are unwell, seek medical advice.Oncology for the Inquisitive Mind is recorded with the support of education grants from our foundation partners Pfizer, Gilead Pharmaceuticals and Merck Pharmaceuticals. Our partners have access to the episode at the same time you do and have no editorial control over the content. Hosted on Acast. See acast.com/privacy for more information.
REDIFF - Comment communiquer dans le couple lorsque se profile une mutation d'un des conjoints ? Qui est le plus souvent lésé et comment cela peut-il être vécu ? En compagnie de Caroline Dublanche, Paul Delair revient sur les témoignages et autres moments qui ont marqué le direct. Chaque soir, en direct, Caroline Dublanche accueille les auditeurs pour 2h30 d'échanges et de confidences. Pour participer, contactez l'émission au 09 69 39 10 11 (prix d'un appel local) ou sur parlonsnous@rtl.frHébergé par Audiomeans. Visitez audiomeans.fr/politique-de-confidentialite pour plus d'informations.
What if forgetting wasn't failure, but actually part of the learning process? In this episode of Knowledge for Teachers, Brendan Lee sits down with bestselling author and educator Kate Jones to explore what retrieval practice really looks like in the classroom. Kate shares practical strategies for making retrieval a habit, clears up common misconceptions, and shows how small tweaks — from scaffolding questions to giving feedback that sticks — can transform learning. Along the way, you'll hear stories from Kate's own teaching journey, insights from research and creative ideas teachers can use right away. Whether you're just starting out with retrieval or looking to deepen your practice, this episode will leave you with simple, sustainable ways to help knowledge stick and build your students' confidence. Resources mentioned: Why Students Don't Like School — Daniel Willingham Love to Teach — Kate Jones Retrieval Practice series (multiple books) — Kate Jones Retrieval Practice: Myths, Mutations and Mistakes (free ebook, Evidence Based Education) — Kate Jones Flashcards ebook (Evidence Based Education) — Kate Jones ResearchEd Guide to Cognitive Science (Kate wrote chapters on retrieval and spacing; Jonathan Firth on interleaving) Dunlosky (2013) - Strengthening the Student Toolbox Retrievalpractice.org (Pooja Agarwal's meta-analysis of classroom studies) Carousel Learning (Adam Boxer) TES (retrieval templates) You can connect with: Twitter/X: @KateJones_teach Email: katesofiajones@gmail.com Website: https://www.katejoneseducation.com/ You can connect with Brendan: Twitter/X: @learnwithmrlee Facebook: @learningwithmrlee Linkedin: @brendan-lee-kft Website: learnwithlee.net Support the Knowledge for Teachers Podcast: https://www.patreon.com/KnowledgeforTeachersPodcast enuine research from marketing spin, why fluency is about much more than speed, and the dangers of relying on “engagement” as a proxy for learning. Anna also highlights simple, practical strategies—like cover-copy-compare and spaced retrieval—that help students build the confidence they need to tackle more complex maths. If you've ever wondered how to cut through the noise and focus on what truly improves student outcomes, this conversation is packed with insights you can take straight back to your classroom. Resources mentioned: Wise Math (advocacy group) Archimedes Math School JUMP Math (Canadian maths program) Singapore Primary Math Program ResearchEd (conference, where Anna presented) Chalk and Talk (Anna Stokke's podcast) You can connect with Anna: Twitter/X: @rastokke Linkedin Website: https://www.annastokke.com/ You can connect with Brendan: Twitter/X: @learnwithmrlee Facebook: @learningwithmrlee Linkedin: @brendan-lee-kft Website: learnwithlee.net Support the Knowledge for Teachers Podcast: https://www.patreon.com/KnowledgeforTeachersPodcast About Dr. Anna Stokke is a Professor in the Department of Mathematics and Statistics at the University of Winnipeg. She is a recipient of a 3M National Teaching Fellowship, which is Canada's most prestigious award for teaching excellence and educational leadership at the post-secondary level. She is co-founder and President of the non-profit organization Archimedes Math Schools, which delivers after-school math classes for children. She hosts the popular math education podcast Chalk & Talk, where she discusses evidence-informed math teaching with leading education experts. 2025 Australian School Improvement Summit The 2025 Australian School Improvement Summit is coming to Sydney on Wednesday 29 October — a one-day event bringing together system leaders, researchers, principals, and expert practitioners to focus on what works in schools, and how to make it happen at scale. Hear from leading voices like Natalie Wexler (The Knowledge Gap), curriculum expert Dr Ben Jensen, and school leaders Lisa Holt (Rosebud Secondary College), Manisha Gazula (Marsden Road Public School), and Dr Greg Ashman (Ballarat Clarendon College). If you're a school leader or educator committed to improving outcomes for every student — and believe in doing fewer things, better — this is an event not to miss. Special offer for listeners: 20% off full-price tickets with code LearnWithLee. Check out the full program and register here: https://shorturl.at/Ku9v4
In today's episode, we had the pleasure of speaking with Stephen Liu, MD, about the use of tepotinib (Tepmetko) in patients with metastatic non–small cell lung cancer (NSCLC) harboring MET exon 14 skipping alterations. Dr Liu is an associate professor of medicine at Georgetown University, as well as the director of Thoracic Oncology and head of Developmental Therapeutics at the Georgetown Lombardi Comprehensive Cancer Center in Washington, DC. In our exclusive interview, Dr Liu discussed key efficacy and safety findings from the phase 2 VISION trial (NCT02864992) that led to the FDA approval of tepotinib for this indication; the comparable response rates seen between tissue and liquid biopsy results, as well as across NSCLC treatment lines; and the importance of early biomarker testing, including RNA sequencing, to identify actionable mutations and optimize treatment.
In this week's episode, we'll learn more about relationships between Epstein-Barr virus genomic variants and human diseases, including hematological malignancies; the presence and timing of somatic GATA1 mutations and their relationship to a Down syndrome-specific form of leukemia; and new definitions for high-risk multiple myeloma that emphasize the presence of two or more high-risk cytogenetic abnormalities.Featured Articles:Association of Epstein-Barr virus genomic alterations with human pathologiesClinical significance of preleukemic somatic GATA1 mutations in children with Down syndromeBiallelic antigen escape is a mechanism of resistance to anti-CD38 antibodies in multiple myeloma
Aging is more than disease—it's the steady decline of function. In this episode of Longevity by Design, Dr. Gil Blander speaks with physicist-turned-biotech innovator Dr. Peter Fedichev about why resilience, not diseases, holds the key to longer lives.Peter explains how his background in theoretical physics shaped his approach to biology and aging. He outlines why startups, not large institutions, are now leading innovation in longevity science. Drawing from physics, he describes aging as a series of “jumps” between states, each leaving the body more fragile.The discussion moves from the limits of current drugs to the promise of new approaches. Peter argues that reducing fluctuations and increasing molecular fidelity could unlock far greater gains in healthspan and lifespan. Listeners gain a fresh lens on what drives aging, where the real breakthroughs may come from, and why the next frontier in longevity will require rethinking the problem altogether. Guest-at-a-Glance
Humans haven't been around for hundreds of thousands of years. We're all descended from Adam and Eve just a few thousand years ago. But what about the animals?
A new MP3 sermon from Answers in Genesis Ministries is now available on SermonAudio with the following details: Title: Mutations—A Challenge for Evolution Subtitle: Answers with Ken Ham Speaker: Ken Ham Broadcaster: Answers in Genesis Ministries Event: Radio Broadcast Date: 9/12/2025 Length: 1 min.
A new MP3 sermon from Answers in Genesis Ministries is now available on SermonAudio with the following details: Title: Mutations—A Challenge for Evolution Subtitle: Answers with Ken Ham Speaker: Ken Ham Broadcaster: Answers in Genesis Ministries Event: Radio Broadcast Date: 9/12/2025 Length: 1 min.
In this week's episode we'll learn about persistent changes in immune profiles in patients who have had diffuse large B-cell lymphoma, or DLBCL, and other cancers; that plasminogen activation and plasmin activity do not appear to play a role in routine physiological prevention of venous thromboembolism, or VTE; and about a novel mechanism that makes hematological malignancies carrying epigenetic mutations susceptible to PARP inhibitors.Featured Articles:Large B-cell lymphoma imprints a dysfunctional immune phenotype that persists years after treatmentPlasminogen activation and plasmin activity are not required to prevent venous thrombosis/thromboembolismTransposable elements as novel therapeutic targets for PARPi-induced synthetic lethality in PcG-mutated blood cancer
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A new MP3 sermon from Answers in Genesis Ministries is now available on SermonAudio with the following details: Title: Mutations Don’t Support Evolution Subtitle: Answers with Ken Ham Speaker: Ken Ham Broadcaster: Answers in Genesis Ministries Event: Radio Broadcast Date: 9/9/2025 Length: 1 min.
The rate at which mistakes pile up in the DNA we inherit from our mothers contradicts evolutionary ideas.
Is your fertility struggle really about MTHFR—or could your genes be pointing to a much bigger story?If you've ever been told that an MTHFR mutation explains why you can't conceive—or if you've tried all the “clean living” advice and still aren't seeing results—this episode is for you. We explore how genetics, oxidative stress, and hidden nutrient weaknesses can quietly impact egg and sperm health, making pregnancy feel out of reach even when you're doing everything “right.”In this episode, you'll learn...-Why MTHFR is only one piece of the fertility puzzle and what else you must consider.-How oxidative stress and genetic predispositions directly influence egg and sperm quality.-The role of functional genetic testing in uncovering hidden causes of unexplained infertility and guiding personalized solutions.Press play now to uncover how your genes and environment interact—and how this knowledge can finally move you closer to growing the family of your dreams.
Jay is excited to be back and even more excited by our guest this week. Taejon Romanik, guitarist and backup vocalist for the Wild Wild Wets, is back to announce a brand new album. We catch up with Taejon and discuss their latest album, Time Mutations, which drops on streaming services today. Get the album and some coffee here.Songs:Wild Wild Wets - “High Rider”Wild Wild Wets - “Sunshine Sue”Wild Wild Wets - “Disintegrate”Next up, News with Nick! Radiohead has released a live version of Hail to the Thief, Sony sues Napster, and Godspeed You! Black Emperor is no longer streaming anywhere.Song: Radiohead - “There There (Live)”Greg has a solid set of tunes to share this week via Three for Thursday. What if Louis Cole played the accordion, you ask? Introducing Anatole Muster. Oasis continues wowing audiences and we dive into an old track by Steely Dan.Songs:Anatole Muster - “Hope Walk”Oasis - “Little By Little (Live 25)”Steely Dan - “Peg”
Nels and Vincent discuss research on hidden evolutionary constraints that dictate the retention of coronavirus accessory gene, which was flagged by NIH as potentially dangerous gain-of-function research. Hosts: Nels Elde and Vincent Racaniello Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiEVO Links for this episode Join the MicrobeTV Discord server Hidden evolutionary constraints and retention of coronavirus accessory genes (Curr Biol) Timestamps by Jolene Science Picks Nels – NIH suspends dozens of pathogen studies over ‘gain-of-function' concerns and Mentorship and acts of kindness Vincent – Kennedy's case against mRNA vaccines collapses under his own evidence Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twievo@microbe.tv
In this episode, we review the high-yield topic of Type of DNA Mutations from the Biochemistry section.Follow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbullets
In this episode, we talk about our unforgettable experience celebrating the 35th anniversary of the TMNT movie in theaters! Our Radical Friends from Dimension X:Follow @EnterSagaArts and @FathomEntertainmentTMNT 35th Anniversary TicketsTMNT Evolution, Mutation and Reboot KickstarterAll Fathers Care for Their Sons (1990 TMNT Movie Scene)Kirklanardo's Regular Time Podcast!Gnarly Nick's Genesis Gems Podcast!Mondo Michael's 2 Dudes and a NES Podcast!Attack of the Big Zach's Booyakashow! TMNT Podcast!Rad Ryan's Talkin' Snikt Wolverine Podcast!Robatello's The Retro Junkies Podcast!Cowabunga Craig's Art/Comics Page!Check out Tubular Tara's Art/Comics Page!Check out Bodacious Beejay's Art/Comics Page!
Welcome to MrMaple Podcasts, your go-to destination for all things horticulture. Our playlist is a collection of podcasts that showcase various plants and interview renowned horticulturists. We aim to educate and inspire our listeners about the beauty of plants and the knowledge needed to cultivate them. Our podcasts cover a wide range of topics, from Japanese Maples, Conifers, Ginkgos, and Azaleas to interviews with experts in the field. Tune in every Sunday at 8PM eastern for a new episode and join us on this journey to discover the wonders of horticulture.
It's Animals Attack August and this week we had guest Holly Chou (from X-Men 97) in the studio to talk about Alligator 2: The Mutation, a movie about a giant alligator who eats people again.Tune in next week when our movie will be... The Grey.-----Watch Holly Chou in X-Men 97 where she plays Jubilee!August 30 from 2pm-5pm Holly will be doing an in store signing at Legends Comics in Clovis, CA Jordan and Holly will be at Cape and Cowl Con at Faction Brewing in Alameda on Aug 24. Find out more here!August 28th, come to the Punch Line Comedy Club in Houston to see Matt and his wife Francesca Fiorentini! https://bit.ly/mattfranhtx
Featuring an interview with Dr Jorge Cortes, including the following topics: Overview of common molecular profiles in newly diagnosed acute myeloid leukemia (AML) (0:00) Clinical presentation of AML with a FLT3 mutation; implications of clinical data from the Phase III RATIFY trial of the FLT3 inhibitor midostaurin (5:38) Potential incorporation of a FLT3 inhibitor with azacitidine/venetoclax for transplant-ineligible patients with FLT3-mutant AML (10:32) Clinical benefit with quizartinib for patients with FLT3-like genetic profile; selection of FLT3 inhibitor as a component of initial therapy for individuals with AML with a FLT3-ITD mutation (14:04) Overview of FDA-approved IDH inhibitors enasidenib, ivosidenib and olutasidenib; differentiation syndrome as a class effect of IDH inhibitors in AML (20:31) Case: A woman in her late 60s with newly diagnosed AML with FLT3-ITD and NPM1 mutations receives 7+3 chemotherapy in combination with quizartinib (31:07) Case: A patient in their late 70s with multiple comorbidities and newly diagnosed IDH1-mutant AML (37:53) CME information and select publications
Featuring a slide presentation and related discussion from Dr Jorge Cortes, including the following topics: Oncology Today with Dr Neil Love: Perspectives on New Datasets in FLT3- and IDH1/2-Mutant Acute Myeloid Leukemia — Dr Cortes (0:00) CME information and select publications
Could cancer actually disprove evolution? This fascinating discussion explores how cellular protection systems pose serious challenges to evolutionary theory. Three sophisticated mechanisms guard us against cancer: tumor suppressor genes that trigger cell suicide, proto-oncogenes that control division rates, and error-correcting systems that fix DNA damage. These complex systems must function perfectly from the start—they can’t evolve gradually. Mutations, supposedly evolution’s driving force, actually destroy rather than create. Dr Don Batten reveals how cancer research unexpectedly undermines the very foundation of evolutionary claims.
Mutation. It is the key to our evolution. As our cells constantly divide and reproduce and replicate our DNA, errors and inconsistencies develop, leading to the incredible variation of life that drives evolutionary change. This episode, we explore the genetic mechanisms behind mutation and we discuss how scientists study mutations to understand the evolutionary history of life on Earth. In the news: Neanderthal tools, caiman food, dancing dinosaurs, and ancient integument. Time markers: Intro & Announcements: 00:00:00 News: 00:09:25 Main discussion, Part 1: 00:40:50 Main discussion, Part 2: 01:35:00 Patron question: 02:28:55 Check out our website for this episode's blog post and more: http://commondescentpodcast.com/ Join us on Patreon to support the podcast and enjoy bonus content: https://www.patreon.com/commondescentpodcast Got a topic you want to hear about? Submit your episode request here: https://commondescentpodcast.com/request-a-topic/ Lots more ways to connect with us: https://linktr.ee/common_descent The Intro and Outro music is “On the Origin of Species” by Protodome. More music like this at http://ocremix.org Musical Interludes are "Professor Umlaut" by Kevin MacLeod (incompetech.com). Licensed under Creative Commons: By Attribution 3.0 http://creativecommons.org/licenses/by/3.0
