Podcasts about Mutation

Welcome back to the AppleGrant Book Club, where we discuss the fifth book in the Remnants series, “Mutation”, by K.A. Applegate!  In this episode, Tim launches his new mini golf tavern, Alex starts talking about Salad Fingers again, Kaycie defines Fralt water which is upsetting, and we all aren't cowards, were just tired.    Join us each month on the first and the fifteenth for new episodes of Animorphs Anonymous / AppleGrant Book Club!

Aujourd'hui dans "Comment j'ai réussi?", Stéphane Pedrazzi reçoit Didier Grychta, PDG du groupe Frio, leader français et européen de la cave à vin. Il nous plonge au cœur d'un marché en pleine transformation. Alors que la consommation de vin en volume diminue depuis les années 60, il explique comment le secteur s'adapte pour répondre aux nouvelles attentes des consommateurs.Tout d'abord, l'invité nous révèle que si la consommation globale baisse, elle se "qualifie" : on boit moins, mais on boit mieux. Cette tendance profite aux fabricants de caves à vin, car plus les consommateurs s'éduquent au vin, plus ils ont besoin de solutions pour le conserver dans de bonnes conditions. Il nous raconte ainsi l'histoire de la marque Climadiff, acquise par le groupe Frio en 2011, qui a contribué à démocratiser ce produit autrefois réservé aux professionnels.Aujourd'hui, le marché des caves à vin est désormais à 80% grand public. Didier Grychta explique les différents formats qui se sont développés, notamment les caves encastrables, très prisées dans certains pays comme l'Allemagne ou les pays nordiques. Il souligne également l'importance du design et de l'intégration de ces appareils dans la cuisine, devenus de véritables objets de décoration.Mais le PDG du groupe Frio ne cache pas les défis à relever, comme la consommation électrique importante de ces équipements, notamment pour les modèles à porte vitrée. Il nous dévoile également les différentes gammes proposées, du très haut de gamme fabriqué sur-mesure en France aux modèles d'entrée de gamme produits en Asie.Enfin, il brosse le portrait de la clientèle, qui va du jeune couple souhaitant conserver les bouteilles de l'année de naissance de leurs enfants aux amateurs de vin, avec une part féminine en constante augmentation. Hébergé par Audiomeans. Visitez audiomeans.fr/politique-de-confidentialite pour plus d'informations.

C'est avec la banane et les agrumes le fruit le plus consommé au monde : la pomme. De la Chine, premier producteur mondial, à l'Argentine, en passant par la Turquie, l'Ouzbékistan ou la Pologne, sa culture est une valeur sûre des zones tempérées. C'est également une star de l'industrie agroalimentaire à travers son dérivé, le concentré de pommes. Or ce marché est en pleine mutation. Vous le consommez sans le savoir dans de nombreux plats : des soupes industrielles, des sauces, des vinaigrettes, où il est utilisé comme adoucissant, et bien sûr dans les jus, les pâtisseries, les yaourts ou encore de nombreux snacks. Des millions de tonnes de concentré de pommes sont produits chaque année partout sur la planète pour fournir l'industrie agroalimentaire, en particulier celle des États-Unis, principale importatrice. Des filières d'approvisionnement en pleine révolution Depuis son entrée dans l'Organisation mondiale du commerce et jusqu'en 2020, la Chine s'était imposée comme LE grand fournisseur mondial de concentré. Plus de la moitié des quelque 80 millions de tonnes de pommes récoltées chaque année le sont en effet sur le sol chinois. Pendant deux décennies, la production de concentré a été une priorité car facile à exporter dans une période où la Chine avait besoin de devises étrangères. Ce n'est plus le cas aujourd'hui, car la demande intérieure en concentré mais aussi en fruit frais a fortement augmenté chez les Chinois. Les producteurs locaux misent donc sur le marché intérieur et ont massivement investi sur les chambres froides pour approvisionner la filière de pommes à l'unité. Résultat, les exportations de concentré chinois se sont écroulées, passant de 1 million de tonnes en 2007 à moins de 300 000 en 2023. À lire aussiEn France, la recherche de nouvelles variétés de pommes pour diminuer les pesticides Une demande mondiale forte avec de nouveaux acteurs La Pologne est devenue la première exportatrice mondiale de concentré de pommes. La filière polonaise s'est structurée ces dix dernières années en investissant sur son infrastructure de transformation. Elle a également bénéficié de faiblesses chez ses concurrentes, avec par exemple de mauvaises récoltes en Turquie en 2025. Cette diversification du marché pourrait également offrir des opportunités à d'autres pays et notamment en Afrique. L'Égypte, l'Afrique du Sud et le Maroc sont en effet dans le top 20 mondial des producteurs de pommes. Avec un avantage pour le royaume chérifien : l'existence d'une industrie de transformation et surtout d'un accord de libre-échange avec les États-Unis. À lire aussiEspagne: de nouvelles variétés de pommes adaptées au réchauffement climatique

Que transmettons-nous sans le savoir ?Dans cet épisode des Sens de la Danse, je reçois Joséphine Tilloy.Chorégraphe, interprète et fondatrice de la compagnie Vibrisses, elle explore à travers ses créations les liens entre mémoire, héritage, féminité et mouvement.Issue de quatre générations d'artistes, elle grandit entre la danse, la gymnastique, les arts plastiques et le théâtre avant de construire une écriture singulière à la croisée de la danse contemporaine, de la performance et de la transmission.Aujourd'hui, ses pièces interrogent les récits que les corps conservent, les normes qui les traversent et les traces invisibles laissées par celles et ceux qui nous ont précédés.Dans cet épisode, nous parlons de son parcours, de son rapport à la création, du rire comme matière chorégraphique, de maternité, de mémoire familiale et de cette question qui traverse tout son travail : que gardent les corps des histoires qui les ont précédés ?Une conversation sensible autour de la danse comme archive vivante.

Aujourd'hui dans "Les voix de l'économie", Stéphane Pedrazzi reçoit Vincent Mortier, directeur général adjoint d'Amundi, le premier gestionnaire d'actifs européen. Alors que la Banque centrale européenne s'apprête à annoncer sa première hausse de taux depuis près de trois ans, il livre son analyse lucide sur les défis auxquels sont confrontées les banques centrales dans un contexte économique et géopolitique en pleine mutation.Alors que l'inflation galopante pousse la BCE à resserrer sa politique monétaire, l'invité met en garde contre les risques de récession que pourrait engendrer ce durcissement. Selon lui, la BCE serait en quelque sorte « prisonnière de sa propre doctrine », condamnée à remonter les taux à court terme avant de devoir les baisser à nouveau face à la dégradation de la conjoncture européenne. Au-delà de la politique monétaire, il décrypte les signaux inquiétants envoyés par les marchés obligataires, avec des rendements qui atteignent des niveaux plus vus depuis la crise de 2008. Un « rappel à l'ordre » adressé aux gouvernements, selon lui, pour faire preuve d'orthodoxie budgétaire face à l'envolée de l'endettement public.Mais l'entretien aborde également les défis géopolitiques auxquels sont confrontés les acteurs économiques, dans un monde marqué par la rivalité entre grandes puissances et la remise en cause des institutions internationales. C'est le thème choisi pour la 17e édition du World Investment Forum organisé par Amundi, que Vincent Mortier présente avec passion.Enfin, il revient sur les interrogations autour de la valorisation des marchés actions, toujours élevée malgré la dégradation de la conjoncture. Une forme d'optimisme qui pourrait cacher des bulles spéculatives, notamment sur les valeurs technologiques américaines.Hébergé par Audiomeans. Visitez audiomeans.fr/politique-de-confidentialite pour plus d'informations.

durée : 00:58:43 - Cultures monde - par : Julie Gacon, Mélanie Chalandon - Le 4 avril 2026, le Français Chan Thao Phoumy était exécuté à Canton. Si la peine de mort relève du secret d'État en Chine, on estime que plusieurs milliers de personnes sont exécutées chaque année, souvent pour des affaires de trafics de drogue. - réalisation : Margot Page, Fanny Richez, Sacha Mattei, Barthélémy Gaillard, Pénélope Le Mauguen - invités : Jean-Philippe Béja Sinologue et politiste, directeur de recherche émérite au CNRS-CERI Sciences Po, Frédéric Constant Professeur d'histoire du droit à l'université Côte d'Azur à Nice, membre des laboratoires Ermes (Équipe de Recherche sur les Mutations de l'Europe et de ses Sociétés) et CRCAO (Centre de recherche sur les civilisations de l'Asie orientale), Sylvia Delannoy Docteure en sociologie, spécialiste de la discipline à Singapour Vous aimez ce podcast ? Pour écouter tous les épisodes sans limite, rendez-vous sur Radio France

Pourquoi certains lieux deviennent-ils des refuges pour les artistes ?Dans ce Pas de côté, je vous emmène dans l'un des endroits les plus emblématiques de Paris : le Ritz.Derrière ses façades élégantes et son histoire prestigieuse se cache un lien discret mais profond avec le monde de la création.Écrivains, musiciens, comédiens, danseurs… depuis plus d'un siècle, des générations d'artistes ont franchi ses portes.Qu'est-ce qui les attire dans ces lieux ?Pourquoi certains espaces semblent-ils nourrir l'imaginaire plus que d'autres ?Une parenthèse pour regarder autrement un lieu que l'on croit connaître.

In this episode of the Oncology Brothers podcast, we discussed challenging cases focused on metastatic non-small cell lung cancer (NSCLC) with common EGFR mutations. Joined by experts Dr. Shirish Gadgeel from the Emory University and Dr. Wade Iams from Tennessee Oncology, the discussion revolved around two real-life patient cases. The first case featured a 54-year-old gentleman with active tobacco use and diffusely metastatic NSCLC, including an isolated brain lesion. The panel explored treatment options, including single-agent osimertinib versus dual combinations of amivantamab-lazertinib and osimertinib-chemotherapy, emphasizing the importance of shared decision-making and considering co-mutations and patient demographics. In the second case, the conversation shifted to supportive care and managing side effects, particularly focusing on skin toxicity associated with amivantamab. The experts shared their proactive approaches to patient education and the significance of monitoring and adjusting treatment plans to enhance patient quality of life.   Key Points: In EGFR-mutated NSCLC with CNS metastases, treatment selection between single-agent osimertinib and combination amivantamab-lazertinib vs. osimertinib-chemotherapy requires individualized consideration of age, co-mutations, extent of disease, and patient preference rather than mutation status alone. Younger patients with CNS disease may benefit from more aggressive upfront combination therapy, while shared decision-making remains central to navigating the expanded efficacy versus increased toxicity trade-off. Dermatologic toxicities associated with amivantamab requires proactive management including supportive care regimen, early dose adjustments and close patient monitoring to maintain treatment continuity. Providing the best available upfront therapy in metastatic EGFR-mutated NSCLC is critical, as sequencing options become more limited at progression. Join us for an insightful discussion on the latest treatment algorithms, the importance of personalized care, and the evolving landscape of NSCLC management.   Listen us on: Spotify: https://open.spotify.com/show/31BXhY9FM4gPWG10WgE11o Apple Podcast: https://podcasts.apple.com/us/podcast/oncology-brothers-practice-changing-cancer-discussions/id1653340966   Follow us on social media: ⁠X/Twitter: https://twitter.com/oncbrothers ⁠Instagram: https://www.instagram.com/oncbrothers Website: https://oncbrothers.com/   Don't forget to subscribe for more episodes featuring conference highlights and challenging cases in oncology! #EGFRMutated, #LungCancer, #ThoracicOncology, #PersonalizedMedicine, #OncologyBrothers

Ce lundi 8 juin, Antoine Larigaudrie a reçu Christophe Vielpeau, notaire à Meaux, dans l'émission Tout pour investir sur BFM Business. Retrouvez l'émission du lundi au vendredi et réécoutez la en podcast.

Danser sur scène… puis faire danser les lieux : comment passe-t-on de l'autre côté du rideau ?Dans cet épisode des Sens de la Danse, je reçois Frédéric Fontan.Nous nous rencontrons au Ritz Paris, dans le jardin où se tiendront les 13, 14 et 15 juin les Nuits Étoilées.Un nouveau festival dont il est l'initiateur et le directeur artistique, réunissant danseurs de l'Opéra de Paris, chanteurs lyriques et musiciens dans l'un des lieux les plus emblématiques de la capitale.Mais avant d'imaginer des expériences immersives pour certaines des plus grandes maisons de luxe, Frédéric Fontan a lui-même passé quatorze ans sur scène. Danseur, chanteur, comédien.Né à Saint-Gaudens, au pied des Pyrénées, il grandit entre les chants populaires, la nature, les études scientifiques et une passion dévorante pour le spectacle vivant.Dans cet épisode, il revient sur son enfance, le harcèlement scolaire, la danse comme espace de liberté, sa carrière artistique, puis sa transition vers la direction artistique.Une conversation sur le mouvement, l'imaginaire, la transmission et le pouvoir des lieux.

Horror fiction anthology featuring mad science, body horror mutations, and medical terror. When human experiments go catastrophically wrong, an asylum doctor transforms into something impossible, a toxic disaster spawns flesh-ripping nightmares, and secret bioweapons become monsters. Four gruesome tales of scientific failure and corporeal dread, expertly narrated with cinematic ambiance for fans of creature horror, horror legends, and dark pulp storytelling.These four tales crawl through the places where the human body stops being safe: an asylum doctor transformed into something impossible, a toxic disaster that unleashes prehistoric predators, a mountain crime scene overrun by man-eating feral hogs, and a warehouse hiding a family secret made of scars, blood, and teeth.Inside this episode:• I Used to Be a Doctor in an Insane Asylum. My Patient Destroyed My World. — by Michael KelsoA psychiatrist working with the most violent patients imaginable loses everything when one of them escapes… but death is only the beginning. After a brutal attack, the doctor awakens as something no longer fully human, becoming an electrical ghost obsessed with revenge. • Night of the Tyrants — by David O'HanlonA criminal nightmare in Fortune, Missouri turns prehistoric when a toxic disaster reveals what a nearby “chemical depot” has really been hiding. Drug dealers, killers, explosions, and rampaging dinosaurs collide in a savage body-horror creature feature. • Hog Wild — by David O'HanlonA botched murder trip leaves criminals stranded in the woods, suspended in a wrecked car above a feeding frenzy of feral hogs. As the bodies fall and the pigs gather below, survival becomes a bloody, brutal fight against nature's ugliest appetite. • Warehouse of Blood — by Shane MigliavaccaA late-night reporter follows a missing-person lead into a family-owned warehouse and finds something much worse than a scoop. Behind the locked doors waits a scarred, hidden, half-forgotten monster who wants to play with his new “dolly.” If you love mad scientist horror, body horror stories, monster horror podcasts, creepy experiments, mutant creatures, revenge from beyond death, and gory pulp horror, this compilation is packed with the kind of nasty surprises that make you check your pulse just to make sure your body still belongs to you.

In dieser Episode spricht Julia über die tiefgreifenden Veränderungen, die das Human Design System für die Jahre 2026 bis 2033 beschreibt. Sie beleuchtet den Wechsel des Inkarnationskreuzes, die zunehmende Bedeutung von Individualität und Eigenverantwortung sowie die Auswirkungen dieser Entwicklung auf Gesellschaft, Beziehungen und persönliche Entscheidungen. Außerdem teilt sie Impulse, wie du dich in Zeiten des Wandels authentisch führen, deiner inneren Autorität vertrauen und deinen eigenen Weg bewusst gestalten kannst.

Et si le krump n'était pas seulement une danse… mais aussi une forme d'élévation ?Dans cet épisode de Un pas de côté, Myriam Sellam explore la dimension spirituelle du krump à travers le parcours du danseur Wrestler.Car derrière la puissance des mouvements et l'intensité des battles, le mot KRUMP porte lui-même une signification étonnante :Kingdom Radically Uplifted Mighty Praise que l'on pourrait traduire par :“Louange puissante radicalement élevée au royaume.” Le krump est né à Los Angeles dans des quartiers marqués par les violences sociales et raciales.Mais il puise aussi dans une culture du gospel, de l'église, du collectif et de la transcendance par le corps.Dans cet épisode, il est question :– d'état de grâce,– de flow,– de transe,– de mémoire corporelle,– et de cette étrange sensation où le mouvement semble nous dépasser.Une réflexion intime et sensible sur le lien entre danse, spiritualité et transformation intérieure.

DML492 Mutation Nation

"Le krump, ça m'a accompagné dans des moments hyper sombres de ma vie. Et en fait, le krump était toujours là. Comme un pote qui te lâche jamais."Ce qui traverse les moments sombres — et qui ressort de l'autre côté — finit par construire quelque chose.Dans cette deuxième partie des Sens de la Danse, Wrestler sort de l'intime pour aller vers le monde. L'Opéra Bastille, le Juste Debout, les créations, la transmission — et cette question qui traverse tout : comment fait-on vivre une culture qu'on a reçue en cadeau ?Un danseur qui devient activiste. Un lutteur qui construit des ponts.

Il est des époques où les tendances changent. Et puis il est des époques où c'est le désir lui-même qui se transforme.Depuis plusieurs mois, le secteur du luxe s'interroge. Ralentissement de la croissance, consommateurs plus hésitants, nouvelles attentes, essoufflement de certains récits de marque, montée des injonctions environnementales et sociales, bouleversements géopolitiques… S'agit-il d'une simple turbulence conjoncturelle ou des signes d'une mutation plus profonde ?Pour tenter d'y voir plus clair, Décousu reçoit Pierre-François Le Louët, président de NellyRodi, cabinet de prospective stratégique qui accompagne depuis plus de quarante ans les acteurs du luxe, de la mode, de la beauté et des industries créatives dans la lecture des transformations de leur époque.Au fil de cette conversation, nous parlons de désir, de prospective, de création, d'intelligence artificielle, de nouvelles générations, de durabilité, de mondialisation, mais aussi de cette question qui traverse aujourd'hui toute l'industrie : comment rester désirable lorsque le monde change plus vite que les modèles qui l'ont façonné ?Les consommateurs ont-ils réellement changé ?Le luxe traverse-t-il une crise passagère ou une transformation structurelle ?Les marques comprennent-elles encore leur époque ?Que faut-il conserver, que faut-il réinventer ?Et surtout : comment distinguer les phénomènes de mode des mouvements de fond qui redessinent déjà l'avenir du secteur ?Un épisode sur l'art délicat de lire son temps, sur ce que le luxe révèle de nos aspirations contemporaines, et sur les métamorphoses silencieuses du désir qui traversent notre époque.Retrouvez Décousu sur instagram : @decousupodcast, et bon épisode !

Episode #146 of Daffy's Round Table! On this episode, I'm joined by Billy Rows off Mutation Creation, one of the most well-known names in the ball python world.We talk about how Billy first got started with ball pythons, his recent move, some of the projects he's most excited about right now, and what he thinks is next for the ball python hobby. We also get into the current state of the ball python industry and the pet industry as a whole — are people still buying animals, is the market still healthy in 2026, and what should breeders be thinking about right now?We also talk about feeding frequency, breeding for yourself versus breeding for other people, and the future of Husbandry Pro, including the launch of Husbandry Pro Next and how the reptile community played such a big role in its growth and success.Huge Thank you to Exo Terra for sponsoring this podcast and making this episode possible. Exo Terra makes quality products for our pet reptiles to make them feel at home! Follow Billy on IG:https://www.instagram.com/mutation_creation/Check out Billy's website: https://mutationcreation.com/ Subscribe to Mutation Creation on Youtube: https://www.youtube.com/ ⁨@MutationCreationCanada⁩ Check out Husbandry pro here: https://husbandry.pro/ Get 15% off your first appointment with Swiftail Exotic Vet Services: https://www.swiftailvet.com/Get 10% off the IncogInverts website with code Daffy10: https://incoginvertscanada.com/Use the code Daffy10 for 10% off at Port Credit Pets: https://portcreditpets.com/ Support the podcast, check out the Patreon page:https://www.patreon.com/cw/DaffysReptilesCheck out our reptile keeper shirts here: https://daffys-reptiles-co.creator-spring.com/Check out my other channel: https://www.youtube.com/ ⁨@daffysreptiles⁩ Instagram: @DaffysreptilesTwitter: @DaffysreptilesFacebook: Facebook.com/DaffysreptilesTiktok: @DaffysreptilesBusiness: daffysreptiles@gmail.com

Dans cet épisode de "Comment j'ai réussi ?", Stéphane Pedrazzi reçoit Sandra Roumi, la directrice générale en France de CoStar Group, une entreprise américaine pionnière dans la collecte et la commercialisation de données appliquées à l'immobilier d'entreprise. L'invitée nous plonge au cœur de cette industrie méconnue du grand public, qui représente pourtant plus de 10% du PIB français et 2,4 millions d'emplois non délocalisables. Elle explique la mission de Costar : digitaliser le secteur de l'immobilier d'entreprise en fournissant aux acteurs (investisseurs, promoteurs, agents immobiliers) des données précises et exhaustives sur les surfaces de bureaux, entrepôts, commerces, etc. L'objectif est d'apporter plus de transparence et de cohérence dans un marché souvent opaque.La cheffe d'entreprise revient sur la méthode de collecte de ces données, qui allie expertise technologique et humaine. Elle détaille les différents types d'informations recueillies, comme les loyers, les surfaces ou l'identité des locataires, et explique en quoi ces données sont stratégiques pour guider les décisions des professionnels de l'immobilier.Elle dresse ensuite un constat sans concession sur la situation actuelle du marché de l'immobilier d'entreprise en France, confronté à une "crise sans précédent". Elle pointe du doigt la surproduction de bureaux, notamment en Île-de-France, face à une demande qui n'est plus au rendez-vous. La conversion de ces bureaux en logements est une piste évoquée, mais qui comporte des défis économiques importants.Au-delà de ce diagnostic, elle met en lumière les profondes mutations qui traversent ce secteur : évolution des usages, des générations, des enjeux environnementaux et numériques. Elle explique comment les données de Costar permettent de mieux appréhender ces transformations et d'y répondre de manière plus éclairée.Enfin, la directrice générale revient sur le positionnement encore méconnu de CoStar en Europe, contrairement aux États-Unis où la marque est très établie. Elle détaille les ambitions de développement de l'entreprise sur le Vieux Continent, avec pour objectif de donner à l'industrie immobilière la reconnaissance qu'elle mérite.Hébergé par Audiomeans. Visitez audiomeans.fr/politique-de-confidentialite pour plus d'informations.

Dans le krump, on ne danse presque jamais seul.Même lorsqu'un danseur est au centre du cercle, il est porté par les cris, les encouragements, l'énergie des autres.On appelle ça : la hype.Dans ce nouvel épisode de Un pas de côté, Myriam Sellam explore cette force collective au cœur du krump :Pourquoi certaines personnes arrivent-elles à se dépasser grâce au groupe ?Pourquoi le regard des autres peut-il parfois nous révéler à nous-mêmes ?À travers l'univers du danseur et activiste krump Wrestler, cet épisode plonge dans une réflexion sensible sur :– la puissance du collectif,– le dépassement de soi,– l'énergie des battles et des sessions,– et notre besoin profond d'être soutenus, vus et encouragés.Un épisode sur la danse… mais aussi sur ce qui nous relie aux autres.

Et si certains corps avaient besoin de lutter… pour rester debout ?Wrestler. Le nom dit tout. À trois ans, au mariage d'un oncle à Cotonou, on lui met sa tenue Michael Jackson, on le place au milieu de la salle. Et il danse. Il n'a pas encore les mots. Mais il sait déjà ce que ça fait. "J'étais le roi du monde. Je me sentais libre."Dans cette première partie des Sens de la Danse, je reçois Wrestler, grand danseur de krump, dont le nom signifie littéralement lutteur — et c'est tout un programme.Avec lui, on plonge dans les origines d'une danse née dans les quartiers de Los Angeles, dans le contexte des violences policières et des émeutes de 1992. On parle de révélation, de style, de familles et de ce que le krump transforme vraiment dans un corps et dans une vie.

Science goes off the rails this week, as we watched the shot-on-video body horror film, Colony Mutation. Join us as we talk about the low budget grittiness, the main character's philandering, and not being able to see what's going on through most of the film. Find us on Bluesky, Instagram, and Threads @TCTAMPod and on TikTok @theycalledthisamovie.Our theme music was written and performed by Dave Katusa. He can be found on Instagram @dkat_productions.

Send us Fan MailSubscribe and unleash your inner science goblin. We see you. We respect it.What happens when your DNA makes a typo?In this episode of Wildly Curious, Katy Reiss and Laura Fawks Lapole dive into the strange, fascinating world of genetic mutations—the tiny changes in DNA that can shape evolution, alter proteins, create disease, or sometimes do absolutely nothing at all. From harmless genetic quirks to serious inherited disorders, this episode breaks down some of the most important mutation types in a way that actually makes sense.

Aujourd'hui, Emmanuel de Villiers, entrepreneur, Abel Boyi, éducateur, et Barbara Lefebvre, prof d'histoire-géo, débattent de l'actualité autour d'Olivier Truchot.

Welcome to the Oncology Brothers podcast! In this episode, we dived deep into the exciting world of metastatic non-small cell lung cancer (NSCLC) with a focus on targeted mutations in the frontline setting. Listen us on: Spotify: https://open.spotify.com/show/31BXhY9FM4gPWG10WgE11o Apple Podcast: https://podcasts.apple.com/us/podcast/oncology-brothers-practice-changing-cancer-discussions/id1653340966 Follow us on social media: X/Twitter: https://twitter.com/oncbrothers ⁠Instagram: https://www.instagram.com/oncbrothers Website: https://oncbrothers.com/ We were joined by Dr. Eric Singhi from MD Anderson Cancer Center, to discuss the latest advancements in treatment options, including: Common EGFR mutations and the benefits of combination therapies over single-agent osimertinib. The role of CNS involvement in treatment decisions and the importance of patient-centered care. Strategies for managing disease progression and the significance of re-biopsy. Insights into ALK-positive disease, including the efficacy of lorlatinib and alectinib. The latest developments in treating rare mutations like NTRK, MET, RET, and HER2. With a wealth of clinical data and practical insights, this episode is packed with valuable information for oncologists and healthcare professionals. Tune in to learn how to navigate the complexities of NSCLC treatment and improve patient outcomes. Don't forget to subscribe for more discussions on oncology topics and share your thoughts in the comments below! #LungCancer, #TargetedTherapy, #PrecisionMedicine, #NGS, #OncologyBrothers

Welcome to the Oncology Brothers podcast! In this episode, we dived deep into the treatment algorithm for metastatic non-small cell lung cancer (NSCLC) without actionable driver mutations in frontline settings. Listen us on: Spotify: https://open.spotify.com/show/31BXhY9FM4gPWG10WgE11o Apple Podcast: https://podcasts.apple.com/us/podcast/oncology-brothers-practice-changing-cancer-discussions/id1653340966 Follow us on social media: ⁠X/Twitter: https://twitter.com/oncbrothers ⁠Instagram: https://www.instagram.com/oncbrothers Website: https://oncbrothers.com/ We discussed the latest updates in lung cancer treatment, including the recent approval of Teliso-V for C-MET overexpressing disease and Zongertinib for HER2 positive cases. We explored the nuances of choosing between single-agent and dual checkpoint inhibitors, the role of PD-L1 scores, and the impact of molecular testing on treatment decisions. Special guest Dr. Christine Garcia, a thoracic medical oncologist and fellowship program director at Weill Cornell Medicine, shared her insights on the importance of biomarker testing, the implications of STK11 and KEAP1 mutations, and the evolving landscape of KRAS inhibitors. Key topics covered in this episode: The significance of NGS testing and PD-L1 scores in treatment decisions The role of chemotherapy in high PD-L1 patients Insights on dual checkpoint inhibitors based on recent clinical trials The latest options for KRAS G12C mutations and C-MET overexpression Practical considerations for managing treatment-related side effects Tune in for an informative discussion that bridges the gap between academic research and community practice in oncology. Don't forget to subscribe for more episodes on treatment algorithms and the latest in cancer care! #MetastaticNSCLC, #Immunotherapy, #KRASG12C, #BiomarkerTesting, #OncologyBrothers

BUFFALO, NY – May 6, 2026 – A new #casereport was #published in Volume 17 of Oncotarget on May 4, 2026, titled “Small bowel GIST harboring concurrent KIT exon 9 duplication and SDHC mutation: A case report.” The study was led by first author Cameron B. Speyer from the UCLA David Geffen School of Medicine, and corresponding author Joseph G. Crompton, who holds appointments at both the UCLA David Geffen School of Medicine and the Jonsson Comprehensive Cancer Center. In this report, the authors describe a rare and clinically informative case of a small bowel gastrointestinal stromal tumor (GIST) harboring two genetic alterations that are typically considered mutually exclusive. GISTs are most commonly driven by activating mutations in the KIT or PDGFRA genes, which confer sensitivity to targeted therapies such as imatinib. In contrast, tumors associated with succinate dehydrogenase (SDH) deficiency represent a distinct subgroup that is generally resistant to these treatments. The patient, a 68-year-old man, presented with progressive abdominal pain, bloating, and constipation. Imaging studies revealed a large heterogeneous mass in the lower abdomen measuring up to 18 cm. A biopsy confirmed a spindle cell neoplasm consistent with GIST, with immunohistochemical staining positive for CD117 and DOG1. Genomic analysis identified both a KIT exon 9 duplication (A502_Y503) and a germline SDHC mutation (p.R50C)—a highly unusual combination. Despite the presence of the SDHC mutation, which is typically associated with resistance to therapy, the patient demonstrated a strong response to high-dose imatinib. After six months of neoadjuvant treatment, imaging showed a marked reduction in tumor size and metabolic activity, enabling successful surgical resection. “This case suggests that oncogenic KIT signaling may remain the dominant driver of GIST behavior despite the presence of a germline SDHC mutation and highlights the importance of integrated molecular interpretation in GIST management.” Pathologic examination of the resected tumor revealed significant treatment response, including extensive necrosis and reduced tumor viability. Notably, immunohistochemistry demonstrated retained SDHB expression, indicating preserved SDH complex function despite the identified germline mutation. The case highlights an important clinical insight: not all detected genetic alterations contribute equally to tumor behavior. While SDH-deficient GISTs are typically resistant to imatinib, this tumor behaved in a manner consistent with KIT-driven disease, underscoring the importance of interpreting molecular findings within their clinical and pathological context. Overall, this report emphasizes the need for integrated molecular analysis in cancer diagnosis and treatment. As next-generation sequencing becomes more widely used, clinicians may encounter tumors with multiple coexisting mutations. Determining the dominant oncogenic driver is essential for selecting the most effective therapy and improving patient outcomes. DOI - https://doi.org/10.18632/oncotarget.28863 Correspondence to - Joseph G. Crompton - jcrompton@mednet.ucla.edu Abstract video - https://www.youtube.com/watch?v=eB_QG2vBNCE Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, GIST, KIT duplication, SDHC mutation, genetic testing, case report To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

A channelled lecture in which the ascended being Helioarcanophus considers the role of thought; how it drives the expansion of the universe and how our human thinking shapes the direction of our own evolution.   Through our thinking, he suggests humanity has deviated from the natural way of the universe, and in so doing created the existence of disease, mutation, pollution as well the other problems we face? Helioarcanophus suggests that our perceptions will change as we evolve but we must learn to understand the importance of thought as a driver for evolution and eradicate fear based thinking in order to return to a universal path of progression. The Wessex Research Group archive contains those lectures that have been digitised and are freely downloadable as a personal educational resource.   https://www.wessexresearchgroup.org

Dr. Michele Matarazzo sits down with Dr. Rebecca Wallings to discuss  how two of the most important genetic forms for Parkinson's disease, LRRK2 and GBA1, influence immune response to bacterial simulation. Their discussion highlights a potential link between genetics, environment, and inflammation in Parkinson's disease. Journal CME is available until March 18, 2027 Read the article.

In this podcast, experts E. Gabriela Chiorean, MD; Tanios S. Bekaii-Saab, MD; Mitesh Borad, MD; and Christopher Lieu, MD, discuss the evolving role of KRAS-targeted therapies in pancreatic cancer, including underlying biology, emerging clinical data, and real-world challenges in treatment selection and trial access.

Dr. Bill Kerr, Co-Founder and CEO of Avalon Healthcare Solutions, highlights the critical role of advanced precision diagnostics and how these tools are driving true precision medicine, where therapies are targeted to specific genetic mutations. There have been significant innovations, such as less invasive liquid biopsies and the application of AI to interpret medical images and complex lab results, which provide faster analysis and make it easier to monitor disease over time. The future of diagnostics includes more routine tests and imaging to enable earlier interventions and more effective treatments by overcoming the logistical and physical challenges of traditional tissue biopsies in cancer care. Bill explains, "At Avalon, we believe that if you don't get the diagnosis right, the rest of healthcare is wasted, and time is wasted on getting a patient better. So our number one focus is getting the science of diagnostics deployed into the healthcare ecosystem. I think a lot of people know that there's been a lot of innovation in lab testing, as well as in advanced diagnostic imaging. And historically, it takes 17 to 20 years to get new science evenly adopted, and we want to accelerate that process. So that's really our focus. We say sciences are True North, and our goal is to get that science deployed into the healthcare system."   "I think, unfortunately, we used the phrase precision medicine too early. When it was really precision diagnostics, and I'll separate the two out. For over a decade, we've been able to measure, let's say for instance, in cancer, what mutations might be in the cancer cells, but we didn't have any new therapies to offer. So while the phrase precision medicine was used, all we did was identify the mutations, build up an understanding of the disease, but offer the same cancer therapy. Now we actually have therapies that target some of those specific mutations."   "We truly have reached the era of precision medicine. But I think getting people to understand that now it's not just measuring the mutation, it's measuring the mutation and selecting the chemotherapy based on that. That's the new reality, and that's what we're trying to get people to understand. And that's why I think undertesting still happens, because people aren't maybe aware that now there are therapeutic decisions you can make off those results." #Avalonhcs #PrecisionMedicine #Diagnostics #HealthcareInnovation #LiquidBiopsy #Healthtech #DiagnosticIntelligence  #AIinHealthcare #PersonalizedMedicine #Oncology #HealthcareProfessionals #MedicalTechnology #PatientCare avalonhcs.com Download the transcript here

Dr. Bill Kerr, Co-Founder and CEO of Avalon Healthcare Solutions, highlights the critical role of advanced precision diagnostics and how these tools are driving true precision medicine, where therapies are targeted to specific genetic mutations. There have been significant innovations, such as less invasive liquid biopsies and the application of AI to interpret medical images and complex lab results, which provide faster analysis and make it easier to monitor disease over time. The future of diagnostics includes more routine tests and imaging to enable earlier interventions and more effective treatments by overcoming the logistical and physical challenges of traditional tissue biopsies in cancer care. Bill explains, "At Avalon, we believe that if you don't get the diagnosis right, the rest of healthcare is wasted, and time is wasted on getting a patient better. So our number one focus is getting the science of diagnostics deployed into the healthcare ecosystem. I think a lot of people know that there's been a lot of innovation in lab testing, as well as in advanced diagnostic imaging. And historically, it takes 17 to 20 years to get new science evenly adopted, and we want to accelerate that process. So that's really our focus. We say sciences are True North, and our goal is to get that science deployed into the healthcare system."   "I think, unfortunately, we used the phrase precision medicine too early. When it was really precision diagnostics, and I'll separate the two out. For over a decade, we've been able to measure, let's say for instance, in cancer, what mutations might be in the cancer cells, but we didn't have any new therapies to offer. So while the phrase precision medicine was used, all we did was identify the mutations, build up an understanding of the disease, but offer the same cancer therapy. Now we actually have therapies that target some of those specific mutations."   "We truly have reached the era of precision medicine. But I think getting people to understand that now it's not just measuring the mutation, it's measuring the mutation and selecting the chemotherapy based on that. That's the new reality, and that's what we're trying to get people to understand. And that's why I think undertesting still happens, because people aren't maybe aware that now there are therapeutic decisions you can make off those results." #Avalonhcs #PrecisionMedicine #Diagnostics #HealthcareInnovation #LiquidBiopsy #Healthtech #DiagnosticIntelligence  #AIinHealthcare #PersonalizedMedicine #Oncology #HealthcareProfessionals #MedicalTechnology #PatientCare avalonhcs.com  Listen to the podcast here

In this podcast, experts V.K. Gadi, MD, PhD; Neil M. Iyengar, MD; and Heather McArthur, MD; discuss advances in breast cancer treatment, endocrine resistance and mutations, and emerging targeted therapies for early-stage and metastatic disease.

Squarepusher - K5 Fremantle - WARPMedlar - Atlantean (Josh Ludlow Remix) - Delusions Of GrandeurFSQ, Moniquea, XL Middleton - Feeling Wide (Prins Thomas Diskomiks Instr.) - Soul Clap x Mofunk Phil Karn (Mutations UK) Black 80's, Fetsum, Jazzanova - Walk With Me - Sonar KollektivNew Jackson - The Night Mail - POGO RecordingsSam Goku - X-Plor09 (Much To Give) - Permanent VacationByron the Aquarius - Song For A Friend (feat. Cropper) - EgloEnaWadan - Inner Joys Of Life - Sonar KollektivMaurice Fulton - Space - TransfusionPhil Karn - Asteroid (2002) - IndépendantMad Professor - H2so4 - Ariwa

Wir leben im Zeitalter der Medizin, Hygiene und stabiler Ernährung – eigentlich perfekte Bedingungen. Müsste die Evolution da nicht längst aufgehört haben?In dieser Folge geht es darum, warum genau das nicht stimmt. Wir sprechen über neue genetische Varianten, die in den letzten 10.000 Jahren entstanden sind, über überraschende Entwicklungen wie Laktosetoleranz oder Zöliakie – und darüber, warum manche Gene sich durchsetzen, obwohl sie auf den ersten Blick eher nachteilig wirken.Es geht um Neandertaler, Rauchen und längeren Schulbesuch.00:55 Der Neandertaler03:15 15.000 Proben08:40 Evolution passiert noch12:13 Das Schul-Gen

It's New Tunesday: new releases from the past week! Give the bands a listen. If you like what you hear, support the bands! Today's episode features new releases by Dekad, VennTronix, Mutation 73, Any Second, Dina Summer, Haunted House, Bustié, Semiotics Department Of Heteronyms, Midnight Poetry, The Spoiled, Cold Union, Ian Leding, and Guilty Strangers!

Eric and Nick talk about their experience in the recent New Hampshire District Championship, and then the new Banlist updates.Cambridge Megacities:https://alwaysberunning.net/tournaments/5380/cambridge-ma-megacity-championshipDullbulb's YT Channel: https://www.youtube.com/@DullBulb123▶PATREON◀⁠⁠⁠https://www.patreon.com/neonstatic⁠⁠⁠https://www.buymeacoffee.com/neonstaticLink to Neon Hustle, our new side channel where we play things like video games and board games and stuff: https://www.youtube.com/@neonhustle▶DISCORD◀New Hampshire Netrunners Discord: ⁠⁠⁠⁠⁠⁠https://discord.gg/SHbcRsgJ6T⁠⁠⁠⁠⁠⁠GLC (Global) Discord: ⁠⁠⁠⁠⁠⁠https://discord.gg/glc▶MERCH◀T-shirt: https://neon-static-merch.printify.meAlt Arts: https://www.makeplayingcards.com/sell/neon_staticEmail neonstaticpod@gmail.com to inquire about Neon Static Poker chips!▶CONTACT◀Reach out to us with questions and feedback via:Email: neonstaticpod@gmail.comMastodon: @neonstaticpod▶EQUIPMENT◀https://kit.co/neonstatic/neon-static-recording-gear#netrunner #cardgames #lcg

60 percent of people listening right now carry a genetic mutation — and most have no idea. It could be behind your anxiety, your fatigue, your migraines, your depression. And nobody ever thought to check. The gene has been known since the 1990s. It just never made it out of the research lab and into your doctor's office. Until now. MTHFR is an enzyme your body needs to process your body's master switch for detox, DNA repair, and mood regulation. Between 40 and 60 percent of people carry at least one variant. About 15 percent carry two, which can slash enzyme function by up to 70 percent.  The symptom list reads like modern life: brain fog, fatigue, anxiety, migraines, insomnia, IBS, and slow recovery. For women, add recurrent miscarriage, infertility, and postpartum depression to that list. Our guest, Jamie Hope, is the founder of Methyl-Life®, a company dedicated to providing targeted nutritional solutions for individuals with genetic health challenges. Jamie is passionate about guiding individuals through the often-confusing landscape of genetics and health, empowering them to improve their well-being with effective solutions. KEY TAKEAWAYS 1.    What the MTHFR gene is 2.    The number of people who have this gene mutation 3.    Signs you have the MTHFR gene 4.    How to test for the MTHFR gene 5.    How MTHFR mutations influence mood, stress response, and energy 6.    The Methyl-Life® MTHFR Supplements 7.    The role of methylated and bioactive nutrients in supporting neurotransmitters 8.    Key differences between standard vs. bioactive forms of B vitamins and folate 9.    Practical tips for lifestyle and supplement strategies to support emotional health   è You can learn about Jamie's Methylated solutions at:  https://methyl-life.com/. è You can find the links in the show notes at https://HealthyHomeHacks.com      

With JDK 26 / JEP 500 starting to prevent final field mutation through reflection, it is important that Java projects stop employing that practice. For more, check https://inside.java/podcast

"VARIANTS AND MUTATIONS" Dr Stella joins the show to have the discussion. Tonight at 10pm ET on Lindell TV. #DiamondandSilk http://DiamondandSilkMedia.com Use Promo Code: DIAMOND or TRUMPWON 1. http://DiamondandSilkStore.com2. https://thedrardisshow.com/shop-all/?aff=123. http://PatchThat.com4. https://cardiomiracle.com/?ref=DIAMOND5. https://MyPillow.com/TrumpWon6. https://DrStellaMD.com7. https://www.Curativabay.com/?aff=18. http://MaskDerma.comSee omnystudio.com/listener for privacy information.

durée : 00:09:06 - On n'arrête pas l'éco - Ce matin, zoom sur une industrie au cœur de la bascule vers l'électricité : la filière automobile qui doit faire sa mutation, tout en vivant une crise structurelle. Un reportage dans les Hauts-de-France signé Léa Guedj. - réalisation : Léa Guedj Vous aimez ce podcast ? Pour écouter tous les épisodes sans limite, rendez-vous sur Radio France

This story is derived from ⁠The SCP Foundation Database⁠ and is released under Creative Commons Sharealike 3.0.⁠ ⁠⁠⁠⁠https://creativecommons.org/licenses/by-sa/3.0/⁠⁠⁠ Author: Matt Doggett Facebook Page: https://www.facebook.com/MatthewDoggettAuthor/ Website/Newsletter sign up: matthewdoggettauthor.com New Book Releases: https://www.amazon.com/Matthew-G-Doggett/e/B08FD5378Z * * * CONTENT DISCLAIMER: This episode contains explicit content not limited to intense themes, strong language, and depictions of violence intended for adults. Parental guidance is strongly advised for children under the age of 18. Listener discretion is advised.  #thescpexperience #scp #scpfoundation #scpencounters #securecontainprotect #scpstories Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode, JF and Phil bring together two visionary essays on the daimonic and the imaginal: Cristina Campo's “On Fairy Tales” and M.C. Richards's “Wrestling with the Daimonic.” What emerges is a conversation about imagination, personhood, and a world shot through with meaning. Notably, this episode opens with a discussion of what your hosts mean by "imaginal." Phil's reading of Richards's essay can be found on our Patreon page. Thanks to Wesleyan University Press for permission to share this with our listeners. Go to Pierre-Yves Martel's Bandcamp page to preorder his marvellous new album, Weird Studies Volume 3. Click here to sign up for JF's seminar on Henri Bergson, happening on the Mutations learning platform on Saturday, April 11, 2026. Click here for details on JF's upcoming Weirdosphere course, "What is Philosophy?". Music in this Episode "Scavenger," from ⁠Weird Studies Vol. 3⁠ "Domes and Spires," from ⁠Weird Studies Vol. 2⁠ References M. C. Richards, American artist and philosopher Cristina Campo, Italian poet and essayist M. C. Richards, “Wrestling with the Daimonic”  Cristina Campo, “On Fairy Tales” Henri Bergson, Matter and Memory William Blake, “Auguries of Innocence” Weird Studies, Episode 8 on Graham Harmon Susan Chang, The Tarot Podcast Ramsey Dukes, The Little Book of Demons “The Boy Who Knew No Fear,” fairy tale  Una Voce, Catholic movement  Franz Liszt, Hungarian Pianist Walter Benjamin, The Storyteller William Shakespeare, Othello  M. C. Richards, Centering Robert Duncan, American poet Learn more about your ad choices. Visit megaphone.fm/adchoices

Welcome to OncLive On Air®! I'm your host today, Kyle Doherty.OncLive On Air is a podcast from OncLive®, which provides oncology professionals with the resources and information they need to provide the best patient care. In both digital and print formats, OncLive covers every angle of oncology practice, from new technology to treatment advances to important regulatory decisions.In today's episode, we spoke with David Morris, MD, FACS, and Alan H. Bryce, MD. Dr Morris is the president of Urology Associates, PC, in Nashville, Tennessee. Dr Bryce is a medical oncologist and the chief clinical officer of City of Hope Cancer Center Phoenix in Arizona.In our exclusive interview, Drs Morris and Bryce discussed the clinical implications of the FDA's full approval of rucaparib (Rubraca) for BRCA mutation–associated metastatic castration-resistant prostate cancer (mCRPC), including the notable data that supported the regulatory decision and how this agent fits into the mCRPC treatment paradigm.

Why Listen? Find out why Peter Parker's body might be failing him in the newest trailer and which secret X-Men cameo just changed the trajectory of the MCU. Whether you are curious about the "Man-Spider" theory or the political fallout of Wilson Fisk's mayoralty, this episode provides the deep-dive analysis you need to stay ahead of the curve. What You'll Learn The Man-Spider Theory: Evidence of Peter Parker's mutating body and organic web-shooters. MCU Mutants: The subtle clues pointing to Sadie Sink as the MCU's Jean Grey. The Golden Path: Why Paul Atreides' journey in Dune is darker than you think. Kingpin's New Era: What to expect from the premiere of Daredevil: Born Again Season 2. Is Peter Parker Mutating into Man-Spider? In this episode, Frank and Squeaks break down the high-octane Spider-Man: Brave New World trailer. We explore the haunting theory that Peter's powers are evolving—or decaying—into something more monstrous. With Peter increasingly isolated and stalking his old friends, the stakes have never been more personal. We also look at the Hulk's mysterious arm brace and what it means for the return of a more "Savage" version of the character. Did the X-Men Just Secretly Arrive in the MCU? The nerd world is buzzing about a specific jacket seen in the trailer. Could Sadie Sink be playing a young Jean Grey, or is this another Black Cat bait-and-switch? We analyze the visual evidence and discuss how the MCU is slowly "dropping" mutants into the narrative without a formal announcement. We also spot some deep-cut comic villains like Boomerang and Tarantula that suggest a more grounded, street-level focus for this installment. How Will Dune Handle the Terror of Face Dancers? Shifting gears to Arrakis, we dive into the latest Dune footage. The focus shifts to the terrifying "Face Dancers"—shapeshifters who can infiltrate any organization. We discuss the "Golden Path" and Paul Atreides' realization that his rise to power will be paved with blood. This segment explores the psychological horror elements being brought to the forefront of the sci-fi epic. Timestamps and Topics 00:00:00 - Introductions and Patreon shoutouts. 00:01:13 - Spider-Man: Brave New World trailer reaction. 00:03:10 - Peter Parker's mutation and the "Man-Spider" theory. 00:07:53 - Analyzying the Sadie Sink / Jean Grey cameo clues. 00:15:09 - Dune trailer breakdown: Face Dancers and the Golden Path. 00:26:58 - Daredevil: Born Again Season 2 Pre-Game and Kingpin's empire. 00:46:00 - Recommendation of the Week: Primal by Genndy Tartakovsky. Key Takeaways Isolated Hero: Peter Parker's "fresh start" has left him more vulnerable and potentially more dangerous as he struggles with his changing biology. The Mutant Blueprint: The MCU is likely using background characters to establish X-Men lore before the formal team-up. Political Warfare: Daredevil Season 2 isn't just about fighting; it's about Wilson Fisk legitimizing his power through the Mayor's office. Sci-Fi Horror: Dune is leaning heavily into the "Face Dancer" shapeshifting lore, which adds a layer of paranoia to Paul's journey. Quotes "I think a lot of people wanted a grounded Spider-Man, but we're also kind of getting this isolated Spider-Man as well." "Imagine if Fisk was handing that key over instead of her. I'd lose my damn mind." "He knows the golden path is going to be laid in blood. He has to conquer the universe first." Call to Action Follow the show right now so you never miss a theory! If you enjoyed this breakdown, please leave a five-star review on Apple Podcasts and share this episode on social media using the hashtag #GeekFreaks. Your support helps us climb the charts and keep the lights on in the nerd-cave. Links and Resources HELP OUR FRIENDS IN HAWAII: https://hawaiifoodbank.org/  Source Website: GeekFreaksPodcast.com Searchable Transcripts: GeekFreaksPodcast.com/transcripts Related Episode: Our Dune Part 2 Deep Dive (Check our archive) Follow Us Stay connected with the crew! TikTok/Instagram/X: @GeekFreaksPod Join our community on Discord to discuss the latest trailers. Listener Questions Is Paul Atreides a hero or a villain in your eyes? Do you think Sadie Sink is playing Jean Grey? Send your theories and questions to our social handles or via our website to be featured in next week's episode! Spider-Man, Marvel, MCU, Dune, Daredevil, Kingpin, Hulk, Jean Grey, X-Men, Primal, Genndy Tartakovsky, Podcast, Nerd News, Movie Trailers.

This is a NerdySouth Entertainment joint!   Season 7 of 30&Nerdy Podcast is brought to you by Fanboy Expo. With multiple shows throughout the year, Fanboy Expo has something for everyone. Whether you're a fan of anime, comics, cosplay, sports, or any other aspects of the Nerdiverse; Fanboy Expo is the show for you. Whether we're in Knoxville, Tennessee, Orlando, Florida, or in your city, You don't want to miss out on the excitement. Come see why people travel from all across the globe to take part in Fanboy Expo. To get the latest info like celebrity guest announcements, event information, cosplay contests, giveaways, and so much more, follow us on Facebook, Instagram, or sign up for our newsletter at fanboyexpo.com.   Welcome back into the pod with the Duke of Nerds and The Juice. In this episode, they are scouring the sewers of The Nerdiverse and breaking down one of the elusive IPs that has evaded them for years…TMNT!   30&Nerdy Podcast's Opening Rift: Kyle Standifer The Ballad of 30&Nerdy: Beth Crowley Fanboy Expo Ad Music: “Omega” by Scott Buckley   This Episode is brought to you by: Fan Boy Expo  Fill Her Cup use the code 30&Nerdy at checkout for 30% Off Hippie Water use the code NERDYSOUTH at checkout Advertising Expressions Encore Theatrical Company Shane's Rib Shack Hwy 81 McDonough, GA   Reaper Apparel Company 30&Nerdy Podcast is an Ambassador for Reaper Apparel Co. If you are interested in checking out all the great attire they have, or learning more about them; click here and if you want to purchase something, don't forget to use our code 30ANDNERDYPOD at check out for 10% off of your order!   You can learn more about NerdySouth Entertainment and its content by visiting The Fortress of NERDitude and while you are there, subscribe to our Nerdly Newsletter for behind the scenes, announcements, and Nerdly News updates. You can also check out the other shows and content under NerdySouth Entertainment   For more NerdySouth content, find us on all social media outlets: Instagram YouTube TikTok Facebook   Email us at 30andnerdypod@gmail.com    Shop Nerdy at NerdySouth Studios   Cheers To Ya Nerds!                                                                                                                                                                                                                                                                

Track-By-Track Album Battle Blue Öyster Cult Tyranny and Mutation Vs. Secret Treaties

“Being sick is expensive.”In this powerful episode of Inside the Vault, Ash Cash sits down with Yahki Awakened to explore the economic, psychological, and biological realities behind modern illness.From surviving a heart attack at 21 to transforming his life through fasting and detoxification, Yahki shares how toxicity, inflammation, deficiency, and environment impact long-term health — and why true wealth starts with physical vitality.Inside this episode:• Why sickness has an economic impact• Toxicity → deficiency → adaptation → mutation explained• The role of inflammation in modern disease• Fasting, detoxification & cellular repair• Seed oils, sugar & environmental toxins• Circadian rhythm & sleep health• Blue zones & longevity principles• The psychology of ingestion• Why simplicity may be the ultimate medicineThis episode challenges conventional narratives while encouraging listeners to take ownership of their health and lifestyle choices.Health is not just personal — it's financial.⏱ TIMESTAMPS00:00 – The True Definition of Food02:08 – Welcome to Inside the Vault02:33 – The Economics of Sickness04:32 – Who Is Yaki Awaken?05:37 – Heart Attack at 2107:09 – Discovering Natural Healing08:53 – 120-Day Juice Fast11:11 – Fasting & Mental Clarity14:26 – Health & Wealth Connection16:34 – Loneliness & Emotional Health19:11 – The Cost of Ignoring Health21:11 – Healing Before Purpose23:10 – Modern Health System Discussion25:05 – Is Health a Financial Strategy?27:42 – Simplicity & Healing32:21 – Inflammation Explained36:19 – The “Neo” Analogy37:21 – Cellular Detoxification41:43 – The McDonald's Example43:37 – Tumors & Toxicity Discussion45:40 – Healing Crisis & Placebo47:04 – Major Dietary Toxins51:24 – Sunlight & Mineral Health52:00 – Clothing & Environmental Factors55:15 – Sleep & Hormonal Health59:28 – Alkaline Diet Explained1:03:19 – Blue Zones & Longevity1:07:27 – Mutation & Adaptation1:08:20 – First Steps to Reset1:10:28 – 21-Day Juice Plan1:14:01 – Why Natural Healing Gets Criticized1:15:22 – Food & Influence1:19:55 – Where to Connect1:23:26 – Final Thoughts: Health Is WealthAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

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Dr. Alex Marson, MD, PhD, is a professor of medicine at the University of California, San Francisco. We discuss the biology of the immune system and cancer, and everyday choices that can increase or decrease your cancer risk, several of which are surprising but all of which are actionable. We also discuss immunotherapy, including how engineered T-cells can be used to defeat childhood and adult cancers. Dr. Marson explains CRISPR and gene editing to cure diseases, and we address the ethical questions surrounding gene editing in embryos, children and adults. This discussion is for anyone interested in avoiding cancer and/or seeking to understand the science and practical applications of immune- or gene-therapy. Read the show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman BetterHelp: https://betterhelp.com/huberman Helix Sleep: https://helixsleep.com/huberman LMNT: https://drinklmnt.com/huberman Function: https://functionhealth.com/huberman Timestamps (00:00:00) Alex Marson (00:02:21) Diseases & Current Biological Landscape; AI & Computational Tools (00:05:56) Immune System, Innate vs Adaptive Immune System (00:10:55) Thymus, T Cell Selection; B Cells & Antibodies (00:13:23) Sponsors: BetterHelp & Helix Sleep (00:16:11) Immune System Health, Sleep, Diet; Genes (00:20:56) Childhood Exposure & Allergy Prevention; Autoimmune Reactions (00:25:27) Whole Body Immune Response, Cytokines & Fever; Antibiotics (00:30:51) Cancer; Mutations & Cell Regulation; Smoking, BRCA Mutations, Sunlight (00:38:27) BRAC Mutations, Mutagens, Pesticides (00:42:33) Sponsor: AG1 (00:43:57) X-Rays & Airport Scanners, Carcinogen vs Mutagen, Charred Meat, Food Dye (00:49:34) Immune-Based Cancer Treatment, Checkpoint Inhibitors, CAR T-Cell Therapy (00:59:04) CRISPR, Immunotherapies (01:02:52) Age & Cancer Risk; CAR T-Cells, Targets & Side Effects; Ketogenic Diet (01:08:27) CRISPR Discovery & Mechanism (01:17:06) CRISPR Precision, Risk & Benefit; CRISPR Technology Evolution (01:20:57) Sponsor: LMNT (01:22:17) CRISPR Cell Delivery, Clinical Trials; Treating Early Cancers & Prevention (01:33:47) Liposomes, Engineered Viruses, Lipid Nanoparticles (LNPs), Vaccines (01:39:57) COVID Pandemic & Trust in Science, mRNA Vaccine (01:47:51) Sponsor: Function (01:49:39) Drug Delivery to Cancer, Immunotoxins, T-Cell Engagers; AI Protein Targets (01:55:45) CRISPR Embryo Modification, Ethics; Heritable Gene Editing, Diversity (02:05:42) Deep Sequencing Embryos, Diversity; Overcoming Adversity & Resilience (02:10:44) Upcoming Therapeutics, Autoimmunity & CAR T-Cells, CRISPR & Gene Function (02:17:55) Banking T Cells or iPSCs?, Future of Cell Programming (02:24:41) Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

On a classic episode of ID the Future out of the vault, host and evolutionary biologist Jonathan McLatchie sits down with software R&D engineer Jonathan Bartlett to discuss Bartlett's work on the question of when genetic mutations are random versus directed. Bartlett explains that the issue isn't an all-or-nothing affair. Often a given biological system dramatically limits the search space of possible mutations in useful ways, and then within that much more limited set of possible mutations, random processes are at play. He gives the example of antibody mutations. He argues that many biological systems show considerable evidence of having been beneficially designed for directed mutations. Why, then, are many mutations deleterious? He also has an answer for that. Tune Read More › Source