Alteration in the nucleotide sequence of a genome
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Pourquoi est-il si difficile de ralentir, même quand on en ressent profondément le besoin ?Ce Pas de côté prolonge l'entretien avec Amara Prum, danseuse de danse classique cambodgienne. Dans cet échange, elle raconte une pratique profondément liée à la lenteur, à la précision, à la présence et au sacré.À partir de là, je me suis demandé pourquoi, dans nos vies, ralentir peut parfois être si difficile.Nous vivons dans un rythme où il faut répondre, produire, avancer, enchaîner. Ralentir peut alors donner l'impression de décrocher, de perdre du temps ou de ne plus suivre.Et pourtant, le corps nous rappelle souvent qu'un autre tempo est possible.Dans cet épisode court, Myriam Sellam, journaliste et créatrice du podcast Les Sens de la Danse, explore notre rapport à la lenteur à travers la danse, le corps, le mouvement, le rythme et la présence.Et si ralentir n'était pas s'arrêter, mais retrouver une autre façon d'être là ?
Dans le cadre des rencontres de la Maison des Professionnels organisées lors du Festival d'Avignon, le 14 juillet 2026 Réditec et l'ISTS ouvrent au débat avec l'Ensatt pour échanger concrètement à propos de certification et de financement des formations, du rôle de l'Etat, des organisations paritaires, des réseaux professionnels et des organismes de formation. Avec : Sébastien Bitot, directeur de Staff David Bourbonnaud, directeur de l'ISTS Jérôme Plaza, directeur technique et membre de Réditec François Weber, coresponsable pédagogique du département Conception Son, ENSATT Cette rencontre était animée par Raphaël Dupeyrot, directeur technique et membre de Réditec. Crédits Production : ARTCENA & ISTS
Dans cet épisode des Sens de la Danse, le podcast créé et animé par Myriam Sellam, je reçois Amara Prum pour découvrir la danse classique khmère, les Apsaras, le Ballet royal du Cambodge et ce que cet art raconte de la mémoire, de la transmission, du sacré et de l'identité.Née en France dans une famille cambodgienne, Amara découvre cette danse enfant. Auprès de ses maîtresses, elle apprend bien plus qu'une technique : un langage du corps, des rites et une manière de rester reliée à ses origines.Des temples d'Angkor jusqu'à la France d'aujourd'hui, nous explorons comment cet art continue de vivre malgré les ruptures de l'Histoire et ce qu'une danse aussi ancienne peut encore nous apprendre dans un monde où tout va vite.Voici son compte instagram: @amara.prum/et son site: https://indradevi.org
durée : 00:29:05 - Les Mystères des lieux - Pour maintenir les chasses sans être éclaboussé par l'héritage royal, François Mitterrand confie leur organisation à un autre François : François de Grossouvre. Mais le comité des chasses révèle bientôt les accents monarchiques de cette présidence mitterrandienne. - équipe : Sandrine Chapron, Emmanuel Laurentin, Laura Dutech-Perez Vous aimez ce podcast ? Pour écouter tous les épisodes sans limite, rendez-vous sur Radio France
Confronté à la montée des tensions internationales, l'espace numérique est devenu un théâtre d'affrontement à part entière. Cyberattaques, espionnage, manipulations informationnelles : les infrastructures numériques sont utilisées à des fins hostiles. Comment fonctionne la cyberguerre ? On en parle avec notre invité, Stéphane Taillat, maître de conférences habilité à diriger des recherches à l'Institut français de géopolitique, détaché à l'Académie militaire de Saint-Cyr Coëtquidan. Dans son ouvrage, La cyberguerre publié aux éditions Que sais-je ?, Stéphane Taillat revient sur la manière dont les États, les groupes criminels, les entreprises privées ou encore les activistes politiques s'approprient l'espace structuré par les infrastructures numériques à des fins stratégiques. Comment la cyberguerre est-elle devenue une composante de notre système international ? Quels en sont les acteurs et comment s'en protéger ? Entretien avec Stéphane Taillat, maître de conférences habilité à diriger des recherches à l'Institut français de géopolitique, détaché à l'Académie militaire de Saint-Cyr Coëtquidan, responsable de l'équipe de recherche Mutations des conflits contemporains au Centre de recherche de Saint-Cyr et membre du centre GEODE, partenaire de notre émission. L'IA s'invite à la tribune des Nations unies La 81e session de l'Assemblée générale des Nations unies s'est ouverte cette semaine à New York. Près de 130 chefs d'État et de gouvernement y sont attendus. Chaque édition est un moment particulièrement exposé à la désinformation. Dans sa chronique, Olivier Fourt de la cellule Info Vérif de RFI revient sur ces images mensongères générées par intelligence artificielle destinées à nuire à l'image de marque de certains chefs d'État ou de gouvernement. Ce que l'on sait des soupçons contre l'écrivain Thélyson Orélien L'auteur canadien d'origine haïtienne Thélyson Orélien est accusé d'avoir massivement utilisé l'IA pour son livre C'était ça ou mourir. Les accusations s'appuient sur des résultats de Pangram, un détecteur de texte généré par IA : ce logiciel, considéré comme fiable par plusieurs chercheurs, assure que la grande majorité du livre aurait été écrite avec l'IA. Alors peut-on vraiment faire confiance à cet outil ? Nathan Gallo, des Observateurs de France 24, a mené l'enquête. À lire aussiUn livre écrit avec l'IA ? Ce que l'on sait des soupçons portés contre l'écrivain Thélyson Orélien
Confronté à la montée des tensions internationales, l'espace numérique est devenu un théâtre d'affrontement à part entière. Cyberattaques, espionnage, manipulations informationnelles : les infrastructures numériques sont utilisées à des fins hostiles. Comment fonctionne la cyberguerre ? On en parle avec notre invité, Stéphane Taillat, maître de conférences habilité à diriger des recherches à l'Institut français de géopolitique, détaché à l'Académie militaire de Saint-Cyr Coëtquidan. Dans son ouvrage, La cyberguerre publié aux éditions Que sais-je ?, Stéphane Taillat revient sur la manière dont les États, les groupes criminels, les entreprises privées ou encore les activistes politiques s'approprient l'espace structuré par les infrastructures numériques à des fins stratégiques. Comment la cyberguerre est-elle devenue une composante de notre système international ? Quels en sont les acteurs et comment s'en protéger ? Entretien avec Stéphane Taillat, maître de conférences habilité à diriger des recherches à l'Institut français de géopolitique, détaché à l'Académie militaire de Saint-Cyr Coëtquidan, responsable de l'équipe de recherche Mutations des conflits contemporains au Centre de recherche de Saint-Cyr et membre du centre GEODE, partenaire de notre émission. L'IA s'invite à la tribune des Nations unies La 81e session de l'Assemblée générale des Nations unies s'est ouverte cette semaine à New York. Près de 130 chefs d'État et de gouvernement y sont attendus. Chaque édition est un moment particulièrement exposé à la désinformation. Dans sa chronique, Olivier Fourt de la cellule Info Vérif de RFI revient sur ces images mensongères générées par intelligence artificielle destinées à nuire à l'image de marque de certains chefs d'État ou de gouvernement. Ce que l'on sait des soupçons contre l'écrivain Thélyson Orélien L'auteur canadien d'origine haïtienne Thélyson Orélien est accusé d'avoir massivement utilisé l'IA pour son livre C'était ça ou mourir. Les accusations s'appuient sur des résultats de Pangram, un détecteur de texte généré par IA : ce logiciel, considéré comme fiable par plusieurs chercheurs, assure que la grande majorité du livre aurait été écrite avec l'IA. Alors peut-on vraiment faire confiance à cet outil ? Nathan Gallo, des Observateurs de France 24, a mené l'enquête. À lire aussiUn livre écrit avec l'IA ? Ce que l'on sait des soupçons portés contre l'écrivain Thélyson Orélien
In today's episode, Narjust Florez, MD, and Jonathan Wesley Riess, MD, MS, hosted a discussion about the distinction between HER2 overexpression and HER2 mutations in non–small cell lung cancer (NSCLC). Dr Florez is the associate medical director of the Cancer Care Access Program and a physician at Dana-Farber Cancer Institute, as well as an assistant professor of medicine and a faculty member at Harvard Medical School, both in Boston, Massachusetts. Dr Riess is the director of Thoracic Oncology and an associate professor of medicine in the Division of Hematology and Oncology at the University of California (UC) Davis Health Medical Center and the UC Davis Comprehensive Cancer Center in Sacramento.In our exclusive interview, Drs Florez and Riess clarified that HER2 mutations, commonly exon 20 insertions, are genomic drivers sensitive to TKIs, whereas HER2 overexpression is a protein finding identified by immunohistochemistry (IHC). They discussed the use of fam-trastuzumab deruxtecan-nxki (Enhertu) for the treatment of patients with HER2 IHC 3+ NSCLC, reviewed efficacy data from the DESTINY-Lung studies, and worked through a treatment sequencing case. Their conversation also addressed toxicity management, particularly aggressive nausea prophylaxis and vigilance for interstitial lung disease, and emphasized the importance of upfront HER2 testing to preserve tissue and save time.
On associe spontanément la danse au corps, au geste, au mouvement.Mais que se passe-t-il avant que le corps ne se mette en mouvement ? Et pourquoi deux personnes exécutant le même geste ne nous donnent-elles jamais tout à fait la même chose à voir ?Dans ce nouvel épisode d'Un pas de côté, je pars d'une phrase prononcée par Lasseindra Xclusive Lanvin au cours de notre entretien : « Danser, c'est de l'esprit. »Une phrase qui ouvre une question passionnante sur les liens entre danse, cerveau, mouvement, mémoire, imagination, musique et personnalité.Que se passe-t-il en nous lorsque nous dansons ? Peut-on déjà danser sans bouger ? Et qu'est-ce qui fait qu'un mouvement parfaitement exécuté devient, ou non, véritablement de la danse ?Un Pas de côté pour regarder autrement ce qui se joue lorsque nous nous mettons en mouvement.
Send us Fan Mail On this episode guitarist Kevin Lindström (Mutation, ex-Beastiality) aka K.L. of Swedish Death Metal band Mutation visits the Morgue to talk about the band's roots and their debut full-length album “Esoteric Order of Debauchery” out October 9th on Hell's Headbangers Records. See you at the Morgue!music:Mutation-Necromantical HolocaustBeastality-SinnerTampa Flamily FitnessMutation-Powers from the VoidMutation-Severed Souls Beastiality-Sacrificial ChantsMutation-Imprisoned with the PharaohsMutation-Pestilent Whore Contact: thetampamorgue@gmail.comThe Tampa Morgue Podcast can be found on Spotify, Amazon Music, Apple Music, Apple Podcasts, YouTube and most places you listen to your podcasts.
Dans cette deuxième partie des Sens de la Danse, Myriam Sellam poursuit sa conversation avec Lasseindra Xclusive Lanvin, longtemps connue sous le nom de Lasseindra Ninja, figure majeure du voguing et de la culture ballroom en France.Après avoir raconté dans le premier épisode sa découverte de la ballroom, les Houses, la famille choisie et son rôle de Mother, Lasseindra va ici beaucoup plus loin.Que devient une culture underground lorsqu'elle gagne en visibilité ? Que reste-t-il de son essence lorsqu'elle entre dans les institutions, les scènes, la mode ou la culture dominante ?Lasseindra livre sa vision, parfois critique, de l'évolution de la ballroom en France. Elle raconte aussi pourquoi, après de nombreuses années au sein de la House of Ninja, elle a ressenti le besoin de changer de House et de devenir Lasseindra Xclusive Lanvin.Mais cet épisode ouvre surtout une réflexion plus intime sur le corps, la transmission, la spiritualité et ce que signifie réellement danser.
Topics Include: Christmas At The Kringles, Other Mommy, Crystal Lake, Below, Mr. Irrelevant, Ghosts: The Possession Of Button House, Mutation, Black Sheeps, and the future of the Alien franchise.
Augustin Lefebvre se penche sur l'histoire des prénoms en France. Depuis l'après-guerre, ils ont connu une transformation spectaculaire. Une étude de l'INSEE révèle que les Français donnent aujourd'hui 8 fois plus de prénoms différents qu'en 1946, marquant la fin d'une époque où Jean, Marie et Michel dominaient largement.Hébergé par Audiomeans. Visitez audiomeans.fr/politique-de-confidentialite pour plus d'informations.
Supporta BLMP genom att bli en patron! Spana in de olika alternativen på http://www.patreon.com/blmetalpodcast Swish: 0708-961174 Mycket missnöje! Hoppla! Ett nytt avsnitt där B.L. lyssnar på frän musik som NI ansvarar för. Just det, ni. Mestadels rått och lite... inte så rått i slutet. Mycket missnöje! Playlist: Destruction - Mad Butcher Saint Delirium - Exquisite Disgust Unholy Redeemer - Journey Beyond Death Mutation - Necromantical Holocaust Sarcator - In Search of Oblivion Hadopelagyal - Tombwake Liturgeia Tungsten - The North Will Rise Blasphemy - Nocturnal Slayer I samarbete med Medborgarskolan.
A research paper recently published in Aging, titled “Human-relevant Ptpn6 mutation alters immune and hepatic functions during aging,” investigated how a human-relevant mutation in the PTPN6 gene, which encodes the immune and metabolic regulator SHP-1, affects immune and liver function during aging. Using mice carrying the mutation, the researchers found that older mutant mice had improved glucose tolerance and hepatic insulin sensitivity, but also developed liver abnormalities characterized by increased fibrosis and the accumulation of immune cells, particularly B lymphocytes and macrophages. Further analyses indicated that these age-related changes were driven primarily by altered immune activity rather than direct effects within liver cells. The findings identify SHP-1 as an important regulator of liver immune homeostasis and provide new insight into how immune-cell infiltration may contribute to age-related changes in the liver. DOI - https://doi.org/10.18632/aging.206413 Corresponding author - André Marette - andre.marette@criucpq.ulaval.ca Abstract video - https://www.youtube.com/watch?v=lyn__UY9Buk Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206413 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, SHP-1/Ptpn6, B cell, macrophage, aging, Ptpn6Ala457Thr To learn more about the journal, please visit https://www.Aging-US.com and connect with us on social media at: Bluesky - https://bsky.app/profile/aging-us.bsky.social ResearchGate - https://www.researchgate.net/journal/Aging-1945-4589 X - https://twitter.com/AgingJrnl Facebook - https://www.facebook.com/AgingUS/ Instagram - https://www.instagram.com/agingjrnl/ LinkedIn - https://www.linkedin.com/company/aging/ Reddit - https://www.reddit.com/user/AgingUS/ Pinterest - https://www.pinterest.com/AgingUS/ YouTube - https://www.youtube.com/@Aging-US Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM
This content was funded by Johnson & Johnson. This material is intended for educational and scientific exchange purposes only. It is not intended to be promotional and should not be used to make treatment decisions for any individual patient. The views expressed are those of the speaker and do not necessarily reflect those of Johnson & Johnson. Atypical EGFR mutations make up approximately 5 to 10% of EGFR-mutant NSCLC, and because some assays only report exon 19 deletions and L858R, they are easy to miss. In this short podcast, Melina Marmarelis, thoracic oncologist at the University of Pennsylvania, explains why these mutations often respond differently to EGFR TKIs and how to pick them up on NGS. She also walks through CHRYSALIS-2 Cohort C, which evaluated amivantamab plus lazertinib in treatment-naive and previously treated patients. Explore: • Why G719X and other atypical mutations alter the ATP-binding pocket differently from exon 19 del and L858R • Which assays can miss atypical mutations, and when broader NGS is needed • What CHRYSALIS-2 Cohort C evaluated, and the limitations of a single-arm phase 1/1b study • How the ASCO living guideline now addresses atypical EGFR alterations Amivantamab plus lazertinib is not approved by the US Food and Drug Administration for the treatment of atypical EGFR-mutated non-small cell lung cancer. This content includes discussion of investigational and unapproved uses. The data presented do not establish safety or efficacy for any unapproved use. Prescribers should consult the full Prescribing Information for approved indications and complete safety information. Speaker: Melina E. Marmarelis, Associate Professor of Medicine, Division of Hematology-Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
BUFFALO, NY — September 16, 2026 — A new #research paper was #published in Volume 18 of Aging on August 28, 2026, titled “Human-relevant Ptpn6 mutation alters immune and hepatic functions during aging.” The study examines how a mutation affecting the immune and metabolic regulator SHP-1 reshapes liver function during aging, revealing that improved glucose metabolism can coexist with immune-cell accumulation and liver fibrosis. The research was led by first author Beisy Laborit Labrada from the Institut Universitaire de Cardiologie et de Pneumologie de Québec (CRIUCPQ), Université Laval, Québec, Canada. André Marette, from CRIUCPQ and the Department of Medicine at Université Laval, is the corresponding author. SHP-1, encoded by the PTPN6 gene, is a protein tyrosine phosphatase that helps regulate both immune responses and metabolic signaling. In immune cells, it generally restrains signaling pathways that control cellular activation, while in metabolic tissues it acts as a negative regulator of insulin signaling. This dual function places SHP-1 at an important intersection between immunity and metabolism, two systems that undergo substantial changes during aging. The study centered on a rare PTPN6Ala455Thr variant originally identified in a French-Canadian family with early-onset severe emphysema. The human mutation moderately reduces SHP-1 phosphatase activity. To investigate its longer-term effects, the researchers used mice carrying the corresponding Ptpn6Ala457Thr mutation and compared young adult mice at 5.6 months with older animals at 16–19 months. Unlike more severe SHP-1-deficient mouse models, these animals have lifespans comparable to wild-type mice, allowing the consequences of partial SHP-1 dysfunction to be examined across aging. Full press release - https://www.aging-us.com/news-room/human-relevant-ptpn6-mutation-reveals-complex-links-between-immunity-metabolism-and-liver-aging DOI - https://doi.org/10.18632/aging.206413 Corresponding author - André Marette - andre.marette@criucpq.ulaval.ca Abstract video - https://www.youtube.com/watch?v=lyn__UY9Buk Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206413 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, SHP-1/Ptpn6, B cell, macrophage, aging, Ptpn6Ala457Thr To learn more about the journal, please visit https://www.Aging-US.com and connect with us on social media at: Bluesky - https://bsky.app/profile/aging-us.bsky.social ResearchGate - https://www.researchgate.net/journal/Aging-1945-4589 X - https://twitter.com/AgingJrnl Facebook - https://www.facebook.com/AgingUS/ Instagram - https://www.instagram.com/agingjrnl/ LinkedIn - https://www.linkedin.com/company/aging/ Reddit - https://www.reddit.com/user/AgingUS/ Pinterest - https://www.pinterest.com/AgingUS/ YouTube - https://www.youtube.com/@Aging-US Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM
Et si la danse pouvait devenir bien plus qu'une pratique artistique ? Un lieu où trouver sa place, créer des liens et parfois même construire une famille.Dans ce Pas de côté des Sens de la Danse, je vous propose d'explorer la manière dont la danse peut faire communauté, à travers un exemple particulièrement fort : la culture ballroom.Née aux États-Unis au sein des communautés LGBTQ+ noires et latinos, la ballroom s'est structurée autour des Houses, des familles choisies au sein desquelles des Mothers et des Fathers accompagnent leurs « kids ». On y danse, on participe aux balls, on apprend les codes du voguing, mais on y trouve aussi de la transmission, du soutien et un sentiment d'appartenance.À partir de l'histoire de la ballroom, ce Pas de côté ouvre une question plus universelle : comment la danse peut-elle créer des liens suffisamment forts pour devenir une forme de famille ?Une autre manière de regarder la danse : non plus seulement comme un art du mouvement, mais comme un espace où l'on se construit avec les autres.
The Apocalypse Players — a Call of Cthulhu actual play podcast
In which our investigators question their allegiances, interrogate colonial tactics (both “successful” & “unsuccessful”), dive deep into the faiths of the townsfolk… and enjoy a performance artist's strange attempts at kickstarting the Whitby Fringe Festival… A Call of Cthulhu scenario by Danann McAleer. Episodes released weekly. Cast: Dr. Henry Carraig-Muire - Joseph Chance Rev. Perregrine McCutcheon - Dan Wheeler Lady Helen Marjorie Bjarmia Potts - Dominic Allen CW: This podcast contains mature themes, strong language and cosmic horror. Human discretion is advised. The Apocalypse Players is an actual play (or live play) TTRPG podcast focused on horror tabletop roleplaying games. Think Dimension 20 or Critical Role, but fewer dragons, more eldritch horrors, and more British actors taking their roleplaying very seriously (most of the time). We primarily play the Chaosium RPG Call of Cthulhu, but have also been known to dabble with other systems, most of which can be found on our Patreon: www.patreon.com/apocalypseplayers We now have a free Discord server where you can come worship at the altar of the Apocalypse, play Call of Cthulhu online, and meet like-minded cultists who will only be too eager to welcome you into the fold. New sacrifices oops we mean players are always welcome. Join here: discord.com/invite/kRQ62t6SjH For more information and to get in touch, visit www.apocalypseplayers.com The Apocalypse Players are: Dominic Allen @domjallen Joseph Chance @JosephChance2 Danann McAleer @DanannMcAleer Dan Wheeler @DanWheelerUK Music and SFX from Epidemic Sound Kevin MacLeod, at Incompetech: Vanishing by Kevin MacLeod Link: https://incompetech.filmmusic.io/song/4578-vanishing License: https://filmmusic.io/standard-license Virtutes Instrumenti by Kevin MacLeod Link: https://incompetech.filmmusic.io/song/4590-virtutes-instrumenti License: https://filmmusic.io/standard-license With very special thanks to Finn McAleer for the use of his fiddle music, especially his album ‘Rough As Folk' (with The Great Bearded Tits). More of Finn's music can be found here: https://www.youtube.com/@finnnnn Epidemic Sound: Radestsky March - Trad. When I am Calling Your Name - Giant Ember Ave Maria - Trad. String Quartet in D - Andante (Trad.) Scorpion Dance - Mike Franklyn Sneaky Fingers (T. Mori) Trollmors Vaggsang (String Quartet Version) - Trad. Prayer - Arvid Svenungsson The Spy - Wendy Martini Hallucinarium - Kalak Lucky Bird - River Run Dry Polska Fran Knaggalve - Trad. Persapojkarnas Polska - Trad. Joyful Occasions - Ludvig Moulin Folksong on Piano - Trad. Horror Composition 5 (SFX Producer) Vivaldi - The Four Seasons, Violin Concerto in E Major, Op. 8 No. 1, RV 269 “Spring” II. Largo e pianissimo sempre - Michelle Ross Vivaldi - The Four Seasons, Violin Concerto in G Minor, Op. 8 No. 2, RV 315 “Summer” III. Presto - Michelle Ross Largo from Xerxes - Trad. Taproot - Esme Cruz Distant Chanting - Jon Bjork Vacuum Sealer - Edward Karl Hanson It Lurks Below - Trailer Worx Godsend - Johannes Bomlof Amaranth Fields - Reynard Seidel Let Them Try - Hampus Naeselius Evil Intentions - Experia Trailed By Horror - Trailer Worn Av Jord, Till Jord - Silver Maple Hold Me Now - Spring Gang Eye For Detail - Jay Barton It Will Fall - Daniella Ljungsberg Scandinavian Folk 10 - Trad. Sneaky Steak - Daniel Fridell House of Horror - Marc Torch Sign Here - Enigmatic Serenity's Reality 5 - August Wilhelmsson Jokers - Mary Riddle Corrivation - Ethan Sloan Fear of the Dark - Etienne Roussel Shadows Unseen - DEX 1200 Onus - Ethan Sloan O'Connor's Jig - Roy Edwin Williams Game Over - Daniel Fridell
BUFFALO, NY — September 14, 2026 — A new #review was #published in Volume 18 of Aging on August 26, 2026, titled “Assessing mechanisms and evidence of a causal role for cellular senescence and somatic mutations in aging.” The review examines two biological processes strongly associated with aging—cellular senescence and somatic DNA mutations—and evaluates whether the evidence supports their causal contribution to age-related functional decline. The review was authored by Lucrezia A. Trastus and Fabrizio d'Adda di Fagagna from IFOM ETS – The AIRC Institute of Molecular Oncology in Milan, Italy. d'Adda di Fagagna is also affiliated with the Istituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche (IGM-CNR) in Pavia, Italy. Both authors are corresponding authors. Aging involves many interconnected molecular and cellular changes, making it difficult to distinguish processes that actively drive deterioration from those that simply accompany it. Trastus and d'Adda di Fagagna assess cellular senescence and somatic mutations using necessity and sufficiency as key criteria for causal inference. For cellular senescence, the evidence for causality is comparatively strong. Senescent cells undergo stable proliferative arrest, which can impair tissue regeneration, particularly when stem cells are affected. Their influence can extend far beyond individual cells through the senescence-associated secretory phenotype (SASP), a complex secretory program that allows senescent cells to alter surrounding tissues and promote senescence in neighboring cells. Full press release - https://www.aging-us.com/news-room/evidence-for-cellular-senescence-as-a-driver-of-aging-stronger-than-for-somatic-mutations DOI - https://doi.org/10.18632/aging.206414 Corresponding authors - Lucrezia A. Trastus - lucrezia.trastus@ifom.eu, Fabrizio d'Adda di Fagagna - fabrizio.dadda@ifom.eu Abstract video - https://www.youtube.com/watch?v=XHTBAJHjRZU Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206414 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, cellular senescence, somatic mutations, DNA damage, SASP To learn more about the journal, please visit https://www.Aging-US.com and connect with us on social media at: Bluesky - https://bsky.app/profile/aging-us.bsky.social ResearchGate - https://www.researchgate.net/journal/Aging-1945-4589 X - https://twitter.com/AgingJrnl Facebook - https://www.facebook.com/AgingUS/ Instagram - https://www.instagram.com/agingjrnl/ LinkedIn - https://www.linkedin.com/company/aging/ Reddit - https://www.reddit.com/user/AgingUS/ Pinterest - https://www.pinterest.com/AgingUS/ YouTube - https://www.youtube.com/@Aging-US Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM
Dans ce premier épisode des Sens de la Danse, Myriam Sellam reçoit Lasseindra Xclusive Lanvin, que beaucoup connaissent encore sous le nom de Lasseindra Ninja.Figure majeure du voguing et de la culture ballroom en France, aujourd'hui Legend, elle revient sur un parcours qui commence en Guyane, passe par New York, puis Paris.À 12 ou 13 ans, elle découvre à New York la ballroom. Un univers qui va profondément changer son rapport au mouvement, à la liberté et à elle-même.
Blaue Augen faszinieren seit Jahrtausenden. Ralph Erdenberger erzählt, wie eine genetische Mutation zum Schönheitssymbol wurde und was ein Blick aus blauen Augen noch verrät.
Welcome back to our weekend Cabral HouseCall shows! This is where we answer our community's wellness, weight loss, and anti-aging questions to help people get back on track! Check out today's questions: Angela: I have stage 1 lipedema. recently last 3 years gained about 30lbs. I am 43 and looking for help. I have had lipedema for as long as I can remember feeling my thighs were just SO fatty even when I was thiner. 120-132 lbs I want to feel like me again Erik: Hi Dr. C, I was hoping to get some guidance about protocols. As of now I'm half way through the mold protocol after finishing the CBO protocol this spring. I had pretty bad bacterial overgrowth and mold markers. Ive been out of the mold for a year and was feeling good through the CBO protocol. However, the last week of the CBO protocol was the week of my yearly fishing trip. I had fun but it also involves a lot of processed foods and alcohol. This resulted in my bad joint pain starting mid meal coming back and almost feeling like Im starting over. On the mold protocol the joint pain during and post meal has continued despite eating lower histamine and taking DAO. Im almost 2 months in taking the clean gut probiotic and healthy gut support. Any suggestions what to do after heavy metal detox. Alicja: Hello Dr. Cabral, Thank you for all you do. I'm your long time listener. I'm 43 yo and recently I started noticing my heart working differently. From time to time I experience very forceful heart beat. It is very noticeable and uncomfortable, like a hard thump. I'm not sure what is happening and what is causing it. It happens at random times of days, more and more often, and always at bed time when I try to go to sleep. Last night I counted and had the "hard thump" heart beat about every 10 seconds. Is this dangerous? What should I do about it? My puls is normal and I'm prone to low blood pressure. I'm not out of breath, but when I experience the hard thumps, it is harder to breathe. Why did I started experiencing this? Amy: I heard you mention on an earlier podcast that you have worked with people that have JAK2 mutation. Is there actually a way to treat this naturally without using pharmaceuticals? My mom has this and they had her on a low dose chemo drug. We are wondering what (if anything) can be done naturally to help lower her platelet count. Thank you Dr. Cabral! Anonymous: Hi! Hope you're doing well. I saw a reel on IG that we shouldn't mix bananas and blueberries because blueberries contain flavonoids and banana contains PPO which breaks down flavonoids? Is there any truth to this? And secondly, what do you think about the viral olive oil and lemon shots in the morning? They list so many benefits. If you are a proponent, how much of each would you use? Third question: is dancing a good way of exercising? I don't particularly enjoy other types of exercise like strength training, but dancing is something I could do every other day.. sometimes I could also do pilates but have to force myself to do it.. what would you recommend on a weekly basis? Thank you for your comprehensive answers and all you do, you're such a gem! Thank you for tuning into today's Cabral HouseCall and be sure to check back tomorrow where we answer more of our community's questions! - - - Show Notes and Resources: StephenCabral.com/3872 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!
Steve et Rose Haldeman s'expriment aussi sur quatre sujets, en rapport avec leurs écrits :- les sexualités- la protection de l'enfance- le monde de l'entreprise- la science-fictionPour en savoir plus, vous pouvez les retrouver :- sur leur site internet : stevehaldeman.com- sur leur chaîne Youtube principale : https://www.youtube.com/@steveetrosehaldeman- sur leur chaîne Youtube dédiée à la protection de l'enfance : https://www.youtube.com/@protectiondelenfance- et sur leurs autres réseaux sociaux, dont les liens sont disponibles sur la page d'accueil de leur site.Hébergé par Ausha. Visitez ausha.co/politique-de-confidentialite pour plus d'informations.
durée : 00:45:29 - Le meilleur de la science - par : Mathieu Vidard - Face à la crise que traverse la filière viticole française, l'arrachage peut répondre au besoin de réduire la production de vin. Mais comment transformer ces terres et comment accompagner l'évolution des territoires ? - équipe : Jérôme Boulet, Lucie Sarfaty, Anna Massardier, Joelle Levert, Jean-Philippe Veret, Éléonore Thévenot - invités : Nashidil Rouiaï Docteure en géographie culturelle et politique, spécialiste de l'impact du cinéma sur l'influence politique et culturelle des nations, Anne-Sophie Novel Journaliste et blogueuse spécialisée dans l'écologie, les alternatives durables et la consommation locale Vous aimez ce podcast ? Pour écouter tous les épisodes sans limite, rendez-vous sur Radio France
Et si les meilleures questions sur la danse étaient parfois les plus simples ?Dans ce Pas de côté, je reviens sur une rencontre entre des enfants et des danseurs du CFA du Théâtre du Corps.Un échange qui dit beaucoup de notre rapport à la danse, à l'apprentissage et à cette drôle d'habitude que l'on prend parfois en grandissant : ne plus oser demander ce qu'on ne comprend pas.Parce qu'en danse, même quand on a de l'expérience, même quand on monte sur scène, même quand on devient professionnel, il reste toujours quelque chose à chercher, à ressentir, à essayer.Et peut-être aussi quelque chose à retrouver de l'enfance : la curiosité, la spontanéité, la liberté de poser une question sans se demander si elle est assez brillante.Un épisode court autour de la danse, du mouvement, de la transmission, de l'apprentissage et de ce que les enfants peuvent parfois nous rappeler sur notre manière de regarder, d'écouter… et de continuer à apprendre.
Visioconférence en oncologie thoracique du groupe GOLF de la Société de Pneumologie de Langue Française Les mardis du GOLF © SPLF 2026
Dr. Jared Rutter, PhD, Professor of Biochemistry at the University of Utah and Howard Hughes Medical Institute Investigator, is a leading expert on mitochondria and metabolism. He explains how mitochondria produce the energy for your cells to work but also how they regulate cell growth and replication and thereby contribute to health and disease. We also discuss how mitochondria are linked to aging, cancer, and other diseases. Our conversation explores your metabolism as the composite of trillions of individual cells and points to new ways to improve health, avoid, and treat diseases. Show notes: https://go.hubermanlab.com/297-jared-rutter Pre-order Protocols: https://protocolsbook.com Thank you to our sponsors AG1: https://drinkag1.com/huberman Joovv: https://joovv.com/huberman BetterHelp: https://betterhelp.com/huberman Eight Sleep: https://eightsleep.com/huberman Function: https://functionhealth.com/huberman Timestamps (00:00:00) Jared Rutter (00:02:29) Metabolism, Cells; Aging (00:08:36) Mitochondria, Origin & Cell Complexity (00:13:07) Sponsors: Joovv & BetterHelp (00:15:16) Mitochondria Genome, Inheritance (00:18:18) Mitochondria & Spatial Distribution; Cell-Specific Metabolism (00:25:59) Nutrient Energy, Hormones, Fat Cells (00:31:13) Glucose, ATP Conversion, Pyruvate (00:36:41) Cell Choice: Energy or Growth, Cancer; Virus (00:46:02) Sponsors: AG1 & Eight Sleep (00:48:36) Microbiome, Role of Humans (00:51:44) Molecule Discovery Process, MPC1, MPC2 (00:59:42) Cell Resource Sensing, Fasting, Glucagon, Fat Cells; Neurons, Heart (01:07:03) Cell Resource Allocation, MPC, Heart Failure; Disease (01:11:46) Sponsor: Function (01:13:24) Cell Size vs Fuel Balance, Cell Identity & Disease (01:20:43) MPC Discovery, Genetics, Model Systems (01:24:29) Lactate, Oxygen, Exercise; Energy Prioritization Hierarchy (01:31:32) Cancer, Mutations, Metabolism Changes & Warburg Effect (01:36:18) Cancer Challenges & Therapies (01:43:00) Therapy Combinations, Unique Cancer Mutations & Metabolism (01:48:31) Technology to Visualize Metabolism; Disease, Metabolism & Scents (01:56:34) Excess Energy & Mitochondria, Reactive Oxygen Species (02:01:12) Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices
Et si, pour cette rentrée, on donnait le micro aux enfants ?Pour ouvrir cette nouvelle saison des Sens de la Danse, direction le POC d'Alfortville, où une classe de maternelle s'apprête à vivre une journée pas tout à fait comme les autres.Le matin, la salle est encore vide. 410 fauteuils face à eux. Une vraie scène à découvrir, des lumières, des coulisses, des loges… et quelques heures pour apprivoiser l'espace avant de danser devant le public.À cinq ou six ans, tout prend une autre dimension.Il y a le trac, bien sûr. Les respirations pour essayer de le calmer. La joie de découvrir la scène. Les costumes. Le maquillage. Et cette chorégraphie, Voyage au bout de la mer, peuplée de vent, de nuages, d'étoiles et de tortues.Mais derrière cette journée se cache un projet beaucoup plus large.Porté par Marie-Pierre Canéla et l'association M'Kowa, il fait travailler ensemble des élèves de différents âges, de la maternelle au lycée, autour de la danse et du spectacle vivant.Les plus petits apportent leur imaginaire et leur histoire dansée. Les lycéens imaginent des créations plastiques, des vidéos ou encore des costumes capables d'accompagner le mouvement. Parmi eux, Efi, 16 ans, passionnée de stylisme, découvre qu'en créant un vêtement pour des enfants qui dansent, il faut aussi apprendre à regarder une chorégraphie autrement.Et surtout, les échanges vont dans les deux sens.Les grands apportent leurs techniques, leurs idées, leur savoir-faire. Mais les petits aussi les obligent à changer de regard, à écouter autrement, à prendre au sérieux leur imaginaire.Au fil de la journée, on découvre aussi tout ce que la danse peut faire naître bien au-delà du geste : de l'autonomie, de la confiance, une place dans le groupe, la capacité à faire avec les autres.Puis vient le vrai moment.Le public entre.Le trac revient.Et les enfants montent sur scène.Après leur propre passage, ils deviennent à leur tour spectateurs et rencontrent les danseurs du CFA du Théâtre du Corps, avec qui ils peuvent échanger directement et poser toutes leurs questions.Un reportage immersif, drôle et sensible sur ce que la danse peut transmettre dès l'enfance.Sur ce que signifie trouver sa place.Sur ce que les plus grands peuvent apprendre des plus petits.Et sur cette chose assez merveilleuse : avoir peur avant d'entrer sur scène… puis découvrir qu'une fois qu'on y est, finalement, « ça va »..
Ce lundi 31 août, Antoine Larigaudrie vous présente la boîte à outils dans son émission Tout pour investir sur BFM Business. Retrouvez l'émission du lundi au vendredi et réécoutez la en podcast.
durée : 01:20:16 - Les Nuits de France Culture - par : Albane Penaranda - Dans le cinquième et dernier épisode de la série consacrée au chorégraphe, danseur et cinéaste Gene Kelly, c'est le temps du déclin de la comédie musicale qui est abordé tandis que Gene Kelly est devenu un mythe vivant du cinéma. Une série au micro de Noël Simsolo, enregistrée en 1996. - équipe : Mathias Le Gargasson, Antoine Dhulster, Rafik Zénine, Vincent Abouchar, Emily Vallat, Hassane M'Béchour, INA Vous aimez ce podcast ? Pour écouter tous les épisodes sans limite, rendez-vous sur Radio France
BUFFALO, NY – August 28, 2026 – A new #research paper was published in Volume 17 of Oncotarget on August 19, 2026, titled “Incidence of KRAS G12C mutations in genitourinary malignancies; emerging target in precision medicine.” The study was led by first author Kelly Crane from the Department of Urology at SUNY Upstate Medical University. The corresponding author is K. R. Seetharam Bhat, who is affiliated with the Department of Urology at SUNY Upstate Medical University and Upstate Urology at MVHS. KRAS is one of the most extensively studied oncogenes in cancer, and the G12C variant has become clinically important following the development of mutation-specific inhibitors. Although KRAS G12C-targeted therapy is established in other malignancies, its frequency and genomic characteristics in genitourinary cancers have remained less well defined. To address this gap, the researchers performed comprehensive genomic profiling of 13,654 tumor specimens from patients with metastatic disease, including 1,453 renal clear cell carcinomas, 3,879 urothelial bladder carcinomas, and 8,322 prostate acinar adenocarcinomas. Tumor mutational burden, microsatellite instability, and PD-L1 expression were also evaluated. Across the full cohort, KRAS alterations were detected in 367 tumors, or 2.7%, while KRAS G12C was identified in only 25 tumors, representing approximately 0.2% of all specimens. No G12C variants were found among the renal clear cell carcinomas. In urothelial bladder carcinoma, 24 of 202 KRAS-altered tumors, or 12%, carried G12C, while only one of 158 KRAS-altered prostate tumors contained the variant. Full press release - https://www.oncotarget.com/news/pr/kras-g12c-mutation-identified-as-a-rare-potential-target-in-genitourinary-cancers/ DOI - https://doi.org/10.18632/oncotarget.28912 Correspondence to - K. R. Seetharam Bhat - bhatkuls@upstate.edu Abstract video - https://www.youtube.com/watch?v=me9HXtnDmp4 Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28912 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, KRAS mutation, genitourinary malignancy, precision medicine, emerging target To learn more about the journal, please visit https://www.oncotarget.com and connect with us on social media: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM
In this episode of Wellness Talk, George dives into one of the most common gene mutations and explores how genetic variations may influence the way our bodies function and potentially contribute to disease. He discusses how understanding your genetics can help you make more informed choices about your health, including what nutrients and supplements may be worth looking into to support your body.Then John takes us into the Way to Happiness Guide and its first precept: “Take Care of Yourself.” George and John discuss the simple, everyday habits that can make a meaningful difference in taking care of both your body and your mind—from nutrition and movement to rest, personal care, and making healthier choices.This episode brings together genetics, nutrition, mindset, and practical daily habits to explore an important question: Are we simply stuck with the way our bodies are programmed, or can the choices we make every day help us live healthier, happier lives?
Welcome back to this Danger Room session, y'all! The trio just had to mic up so we could chop it up about X-Men ‘97 Season Two! The anticipation's been building and it's finally back and the hype train is leaving the station. We get into the fly outfits and character designs with a light dive on the many deep cut references. We explore why the pacing of the show felt different this time around. Can't talk about this show without getting into a conversation about the dismissal of the original showrunner and head writer Beau DeMayo, so we get into that too. Had to show love for the continuing and long overdue glow ups for Jubilee and Cyclops. We've been waiting for that. From the fight choreography giving ‘Fantastic Hands And Where To Catch Them' and a bunch of cool cameos, this season delivered enough for us to talk for hours. Plus, the big questions: why does this season feel like we're speed running story arcs, smashing them all together? Is the creative team rushing towards potentially new original stories? You know it wouldn't be us if we didn't ask why Bishop, Forge, and Storm's characters felt sidelined this season. We get into all that, what we loved, what we wished could've been, and our usual antics. Pull up, check out this episode of 2Nerds and an Actor, and tell us what you think in the comments!00:00 — Welcome to the X-Men '97 Timey-Whimey Zone01:44 — Season 2: Time Travel, Trauma & Mutant Mayhem06:57 — No-Spoiler Zone: Is Season 2 Worth the Watch?08:15 — When the Studio Gets in the X-Men's Way14:00 — Is This Season a Bridge… or Just a Very Long Tease?17:03 — Mutations vs. Inhibitor Collars: The Good, the Bad & the Mutant18:16 — Jubilee Finally Gets Her Flowers22:34 — Who Got Left in the Danger Room?27:52 — The Heartstone Ratings Are In29:44 — SPOILAE: Spoilers Are Now on Deck ⚠️31:03 — Bishop, Storm & Forge: Where Did the Character Development Go?36:51 — Are They Speedrunning X-Men History?38:04 — X-Force, X-Factor & the Government's Mutant Problem42:24 — Polaris, Nightcrawler & the Mutants We Loved47:00 — Bishop + Polaris: Ship Happens48:47 — Rogue Is the Emotional Center of Everything50:47 — The Black Character Problem55:44 — Celestials, Sacrifice & Apocalypse's Big Cosmic Job59:09 — Is Nightcrawler Really...? Enter the Nerdspiracy01:02:31 — Are the X-Men '97 Characters Headed for the MCU?01:06:30 — Deleted Scene: Stay for the End Credits Learn more about your ad choices. Visit megaphone.fm/adchoices
In this episode, editor-in-chief Joseph E. Safdieh, MD, FAAN, highlights articles about the impact of the "One Big Beautiful Bill Act" on neurology practice and research, how artificial intelligence is transforming the neurologist's workload, and the relationship between GBA1 mutations and Parkinson's disease.
We continue to travel down the DNA of films about human genes combining with other things. This time we dig into the mad scientist film "The Mutations" starring Donald Pleasence and Tom Baker. We talk about the death of this sub genre, the performances of the bigger named stars and just how much it borrows from "Todd Browning's Freaks".
We discuss "The Mutation." The Animorphs search underwater for a magical sword, but instead they find sexy fish people and a resolution to Marco's new character arc.Listen to our music: https://mushymustard.bandcamp.com/ Email: AABCpodcast@gmail.com Twitter: @AABCpodcast
The squad leaves Colton & Rowan to kick off JAWGUST all by their lonesome. That's okay… We're fine… Not even a big deal… Like, we've got Colton's pick, ALLIGATOR II: THE MUTATION (1991), to discuss anyways… Is it immediately obvious this sequel is missing its big star? Does a PG rating put a damper on the carnage? And, can a two-man podcast crew make an episode longer than the movie itself!? Tune in to find out if we gave this film this a NAY, OKAY, YAY, or SLAY!CHAPTERS:Theme/Intro (00:00:00)What We Been Consuming?/Why We Picked It (00:03:35)Trailer (00:55:45)Synopsis/First Experiences (00:57:26)Review (00:59:42)Rating/What Did You Think? (01:45:54)Horrific Hotline (01:50:32)Promotions (Horrific Hotline/Social Media/Patreon/It Slays Podcast's Horrific Playlist/Events/GIVEAWAY ANNOUNCEMENT) (01:55:13)Upcoming Episode/Outro (01:57:29)Follow us on all social media:FacebookTwitterInstagramTumblrYoutubeTikTokSlasherThreadsBlueskyWant some official Merch?!SHOP HERE!*Intro & Outro Music by Dylan Bailey (IG: @thedylanbailey)*Support the show
Minter Dialogue sur les marques et le marketing digital (minterdial.fr)
Dans cet épisode, Minter Dial accueille Vincent Desportes, expert reconnu en stratégie et leadership, fort d'une longue carrière militaire et auteur prolifique de nombreux ouvrages. La conversation s'articule autour des parallèles fascinants entre la conduite des opérations militaires et la gestion d'entreprise, explorant la force des métaphores issues de la guerre pour penser la compétition et l'engagement en entreprise. Au fil de leur échange, ils questionnent en profondeur la nature du collectif, le rôle central du leadership, la fierté d'appartenance et la transmission d'une vision commune, qu'il s'agisse d'un équipage, d'un corps d'armée ou d'une équipe en entreprise. La discussion met en lumière la nécessité d'un leadership adaptatif dans un monde bouleversé par la technologie et l'intelligence artificielle, tout en rappelant l'importance de la simplicité, de la responsabilité et du courage dans la prise de décision stratégique. Plusieurs points essentiels sont abordés : comment forger un collectif solide, pourquoi la stratégie doit constamment s'ajuster au réel, et en quoi la communication incarnée distingue un véritable leader, qu'il soit militaire ou chef d'entreprise. Préparez-vous à un dialogue nourri d'anecdotes, d'enseignements tirés du monde militaire et de réflexions éclairantes sur l'art de fédérer, d'anticiper et de décider dans l'incertitude.
Heute geht es ins Remstal, nach Großheppach zum Weingut Bernhard Ellwanger. Mein Gast ist Sven Ellwanger, der den Betrieb gemeinsam mit seiner Schwester Yvonne führt. Auf den ersten Blick wirkt dieses Weingut bodenständig, gewachsen und angenehm unaufgeregt. Im Gespräch zeigt sich aber schnell, wie viel Bewegung in diesem Betrieb steckt: Sauvignon Blanc, Junges Schwaben, Bio-Weinbau, Piwis, Spontangärung, starke Privatkundschaft, Rotweinambition – und eine Region, die noch immer mit alten Klischees zu kämpfen hat. Im Zentrum der Episode stehen drei Weine: ein Muskat-Trollinger Rosé, ein Roter Riesling und eine Lemberger-Syrah-Cuvée. Der Muskat-Trollinger Rosé zeigt, dass Duftigkeit, Frucht und Leichtigkeit nicht banal sein müssen. Sven beschreibt ihn als einen der wichtigsten Weine des Betriebs – trocken ausgebaut, aromatisch, frisch und mit einem kleinen Anteil maischevergorener Partie, der dem Wein zusätzlichen Grip gibt. Der Rote Riesling erzählt eine besondere Geschichte: Im Weinberg wurde eine Mutation in einer alten Rieslinganlage entdeckt – eine Fruchtrute mit weißen Rieslingtrauben, eine andere mit rötlichen Beeren. Aus diesem Zufall wurde eine eigene Selektion, die heute als ernsthafter Wein im Sortiment steht: körperreicher, fülliger und säureärmer als klassischer Riesling, aber dennoch mit eigener Riesling-Prägung. Die Lemberger-Syrah-Cuvée führt schließlich mitten in die Frage, wie sich Württemberg heute verändert. Lemberger bringt kühle Beerenfrucht, Frische und regionale Identität; Syrah ergänzt Würze, Körper, Pfeffer, dunklere Noten und Struktur. Im Glas begegnen sich regionale Herkunft und internationale Rebsorte erstaunlich selbstverständlich. Außerdem sprechen wir über Svens Zeit in Neuseeland, Sauvignon Blanc und Fumé Blanc, über die Gruppe Junges Schwaben, über Bio-Weinbau, Bodenaufbau, Humus, Begrünung und Pflanzenschutz, über den Gravitationskeller, über ProWein, Wine Paris, Export, alkoholfreie Produkte und die Zukunft eines Familienweinguts mit großer Sortenvielfalt. Eine Folge über ein Württemberg, das sich leise verändert hat – pragmatisch, beharrlich, bodenständig und im Glas sehr überzeugend.
Spooky season body horror hatches in “Odd Egg” by Alex Grass, a weird creature-horror story about a carton of free eggs, a smiling stranger, and something impossible waiting inside the final shell. After Roger from the mysterious Keystone Cooperative Growers Association leaves Maryellen a dozen farm-fresh eggs and promises that a god lives inside them, breakfast takes a grotesque turn. Eleven shells are empty. The last produces a tiny human head on six spiderlike legs—and the thing does not stay tiny for long. As it grows, feeds, and changes, Maryellen is pulled into a nightmare of body horror, monstrous metamorphosis, dark comedy, and the coming Time of the Egg. A perfect ramp-up to Halloween, this narrated horror story is made for listeners seeking scary Halloween stories, spooky stories, weird fiction, creature horror, body horror stories, and offbeat horror narration with a gruesome pulp-monster edge. This episode marks Alex Grass's first appearance on Weekly Spooky. The ebook of Infernal Tramps: Tales of Weird Terror by Alex Grass is available for only 99 cents on Amazon, and is free to read with Kindle Unlimited. You can also find out more at www.infernaltramps.com.
Prosthetic Makeup Effects Designer — Spider‑Noir, Fallout, Star Trek: Picard Tony zoomed with acclaimed prosthetic makeup effects designer Vincent Van Dyke, whose work continues to redefine how genre characters are built — physically, digitally, and emotionally. From the noir‑soaked streets of Spider‑Noir to the irradiated wastelands of Fallout, Vincent shares the craft, innovation, and storytelling instincts behind some of today's most memorable transformations. Spider‑Noir — Building a Stylized, Shadow‑Driven World Jack Huston's Sandman The Mutated Man‑Spider Fallout — Designing The Ghoul Digital Scanning vs. Plaster Casting SAVE 17% ON PLUS TODAY
When Andrew Miner's son James was diagnosed with an ultra-rare YWHAG mutation, the path forward was anything but clear. In this compelling episode of Sounds of Science, Andrew shares his family's journey, the inspiration behind founding the YWHAG Foundation, and how advancing research is creating new possibilities and renewed hope for families affected by rare diseases.www.ywhagfoundation.org.https://www.criver.com/eureka/ywhag-ultra-rare-mutation-family-hunts-solutions
This episode was originally released on August 2, 2022Just like any good superhero comic, we start this episode with the science going incredibly wrong. Think: vats of toxic waste producing evil mutants that ravage the city. Or maybe not so evil. It really depends on your perspective. Just like the X-men, genetic mutations get a bad rap in the public eye. But they aren't all nasty.Dr. Kaylee Byers speaks with data scientist and evolutionary biologist Dr. Brian Arnold on how the genetic ‘mistakes' known as variants occasionally encode incredible abilities. Odd elephants, hiding in our ocean depths, and Rogue-ish bacteria are just a few examples. Dr. Arnold defends these genetic anomalies, and explains how they can make a huge difference to the future of humanity and life on this planet. Also joining us is marine biologist Dr. Maria Pia Miglietta, who shares an incredible ability sitting in our ocean depths. Immortality.So strap on your capes, because we're heading straight into the strange terrain of “heroic mutations.” Listen to Nice Genes! wherever you get your podcasts, brought to you by Genome British Columbia.Resources: Genetic Mutation - NatureGenomic mutation rates: What high-throughput methods can tell usShane Campbell Staton Group - Tuskless ElephantsIvory poaching and the rapid evolution of tusklessness in African elephants - ScienceReal-Life X-Men: How CRISPR Could Give You Superpowers in the Future - synthego.comIndonesian divers have evolved bigger spleens to hunt underwater - ScienceMutations may reveal how Tibetans can live on world's highest plateau - ScienceThe Immortal Jellyfish - American Museum of Natural HistoryCellular reprogramming and immortality: Expression profiling reveals putative genes involved in Turritopsis dohrnii's life cycle reversalTranscriptome Characterization of Reverse Development in Turritopsis dohrnii (Hydrozoa, Cnidaria)Horizontal gene transfer and adaptive evolution in bacteria - nature reviews microbiologyHorizontal gene transfer overrides mutation in Escherichia coli colonizing the mammalian gut - PNASThe Ship of Theseus Dilemma - Open Okstate
Most of the bands (or their labels) in this episode have done something for Ukraine. Please buy music from Ukrainian artists and/or donate to your preferred Ukrainian Charity and/or to United 24 (https://u24.gov.ua). Слава Україні! Героям слава!Slava Ukrainai! Slava varoņiem!Glory to Ukraine! Glory to the Heroes! DJ Moose Played: Hunter As A Horse, LightSource, Rising Field, Daniel Knutz, STandART, Ex-Hyena, Agonised Too, Silke Bischoff, Mutation 73, MATT HART, Desolate Discotheque, ee:man, digitalENERGY, MILDREDA, Xxäm, Intro – 00:00Hunter As A Horse – Kiss Of Death – Paradise Lost – 00:30LightSource – Drifting (feat. Indigo) – 03:13Rising Field – Distant Lights – 07:15Daniel Knutz – The Cave – 11:08STandART – Gulbji – 22 – 15:21Ex-Hyena – Silent Storm (RADIATOR Remix) – Details Fade – 19:40Agonised Too – I Cry – 25:09Silke Bischoff – Tears (Unreleased) – Tears – A Silke Bischoff Collection – 28:42Mutation 73 – Sirens – Sirens – 33:32MATT HART – FEAR THE HYBRID (Tech Noir Remix by KREIGN) – 36:43Desolate Discotheque – Одиночество – VA Made by Humans – 39:17ee:man – Earthquake In My Head – Earthquake In My Head – 45:38digitalENERGY – Eternity – Eternity Single – 50:02MILDREDA – Damage Done – Realities – 53:33Xxäm – Freshly Fell (Single Mix) – Freshly Fell – 58:48 The original unmodified image used for this episode by Volodymyr Leush on Unsplash or Listen to TheGothicMoose-Episode667 byDJ Moose on hearthis.at Here is the link to download this episode in MP3 Note: After about a year, episodes may no longer be available here or elsewhere. Shows are sometimes missing from Youtube due copyright restrictions. Use the handy built-in player:
Evolution by natural selection relies upon random mutations. But what does "random" even mean? Evolution Talk is also a book! You can find links on the front page of EvolutionTalk.com, or call your local bookstore and ask them to order a copy. Music in this Episode "Whimsical" by Paul Tyan "Time Squid" by Steven O'Brien "Dog Day Afternoon" by Steven O'Brien "Higher Consciousness" by State of Flux
The LA-based clown, multimedia performance artist, and doll stylist (see maddiemutations.com) joins Mary and Mark to talk about her Doll Court show, clown types and the role of the fool, failing on stage, cities as women, silly villains, and more. Will Carol overcome her anxiety to go into the big meeting? Will Maddie keep all the nice dolls to herself? What should the demands of the LA doll union be? How edgy can a clown be? We wrap up with an exercise about numeric levels of joy. Hear more at philosophyimprov.com. Support the podcast and listen ad-free at patreon.com/philosophyimprov. Sponsor: Get 15% off OneSkin with the code IMPROV at oneskin.co/IMPROV.
Mutations sound scary. But the DNA that shaped us is has been mutating since we were born. Some mutations are bad for our health while others are helping us stay alive, sprucing up our livers and fighting off germs. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
Mid-July horror gets mutated, vengeful, infectious, and lost in the woods in this episode of This Week in Horror History, covering the week of July 13 through July 19. This time, we're digging into mad-scientist island nightmares, supernatural revenge literature, one extremely angry killer whale, a science-fiction body-horror classic, biological vampires, and the tiny independent movie that changed horror marketing forever.Inside this episode:July 13, 1977 — The Island of Dr. Moreau opens in U.S. theatersBurt Lancaster brings H.G. Wells' nightmare of science without conscience to the screen in a sweaty, pulpy story filled with animal-human mutations, unchecked authority, and a scientist convinced that nature would be better if he personally rearranged it.July 14, 2020 — The Only Good Indians is publishedStephen Graham Jones delivers one of modern horror literature's sharpest supernatural reckonings as four Blackfeet men discover that something from their past has memory, purpose, and antlers waiting in the dark.July 15, 1977 — Orca opens in New YorkThe post-Jaws creature-feature wave gets stranger, angrier, and surprisingly tragic when a killer whale driven by grief, intelligence, and patience begins pursuing the human responsible for an unforgivable act.July 16, 1958 — The Fly releases in the United StatesA scientist, a teleportation machine, and one tiny insect create one of science-fiction horror's most unforgettable transformations, turning a dream of human progress into a cruel nightmare of mixed bodies and irreversible mistakes.Deep-Cut Spotlight — The StrainGuillermo del Toro and Chuck Hogan drag vampires out of the velvet cape and into the quarantine zone as a passenger plane lands at JFK filled with the dead. What follows treats vampirism like a biological outbreak capable of spreading through New York while officials argue, deny, and react too late.Horror Birthdays This Week:Patrick Stewart, Larry Cohen, Corey Feldman, and James Brolin enter the birthday roll, bringing connections to Lifeforce, Green Room, It's Alive, Q, The Stuff, Friday the 13th: The Final Chapter, The Lost Boys, Gremlins, and The Amityville Horror.Weekly Recommendation — The Blair Witch ProjectThree student filmmakers enter the Maryland woods with cameras, recording equipment, and a local legend, creating a landmark of found-footage horror built from darkness, disorientation, improvised performances, and the terrifying possibility that the footage might be real.Plus, Weekly Spooky returns Wednesday with another fresh original horror story, followed by more terrifying history, strange mysteries, movie talk, and unexplained broadcasts throughout the week.From The Island of Dr. Moreau and The Only Good Indians to Orca, The Fly, The Strain, and The Blair Witch Project, this week in horror history proves that terror can spread through laboratories, guilty memories, dark water, crowded cities, and one cursed corner of the internet.
Gabriel Nunez discusses the discovery of NOD-like receptors, NOD1 and NOD2, in inflammatory bowel disease and how travel and taking a moment to enjoy local culture and art influences his creativity. Host: Cindy Leifer Guest: Gabriel Nuñez Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server HLA and antigen presentation (Hum Immunol, 1987) Bcl2, cell death, and B cells (Nature, 1991) Discovery of NOD1 (J Biol Chem, 1999) Discovery of NOD2 (J Biol Chem, 2001) Mutation in NOD2 and connection to Crohn's disease (Nature, 2001) Time stamps by Jolene Ramsey. Thanks! Music by Tatami. Logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv Information on this podcast should not be construed as medical advice.
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