Alteration in the nucleotide sequence of a genome
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Mutations podcast returns in this short, off-the-cuff episode as Jeremy offers an update on the manuscript (spoiler alert: it is now complete!), introduces a new online class happening in December, and gives listeners a rough sketch of where the show is headed next."Integral Futuring: Reclaiming Time in the Radical Present" is a three-day weekend seminar, beginning on December 5th. One might describe it as a riff on reclaiming the future, planetary thinking, and the need for a new temporality beyond the clock. Presentations are followed by breakout discussions, resource sharing, and Q&A. Join a community of fellow seekers and explorers for a weekend of in-depth conversations and fellowship.Please reach out if you might need a student discount/pay-what-you-can link. No one will be turned away.
Le Juste Debout, c'est bien plus qu'un événement.C'est une histoire, un héritage, un symbole.Depuis plus de vingt ans, Bruce Ykanji a su transformer une passion en un mouvement mondial — un lieu de rencontre pour des milliers de danseurs venus des quatre coins du globe.Mais pour sa 20ᵉ édition, un grand changement se prépare.Un virage symbolique, fort, qui marque une nouvelle étape dans cette aventure humaine et artistique.
En Colombie-Britannique, il y a un groupe d’autruches atteint de la grippe aviaire à la ferme Universal Ostrich à Edgewood. Le troupeau est au cœur d’une bataille judiciaire qui s’est rendue jusqu’en Cour Suprême et le verdict est tombé hier : les 300 autruches devront être abattues. On va revenir au cœur de cette histoire. Entrevue avec Jean-Pierre Vaillancourt, président de l’Association mondiale de biosécurité animale. Regardez aussi cette discussion en vidéo via https://www.qub.ca/videos ou en vous abonnant à QUB télé : https://www.tvaplus.ca/qub ou sur la chaîne YouTube QUB https://www.youtube.com/@qub_radioPour de l'information concernant l'utilisation de vos données personnelles - https://omnystudio.com/policies/listener/fr
durée : 02:31:38 - Les Nuits de France Culture - par : Antoine Dhulster - En novembre 2000, la superpuissance américaine est interrogée à l'aube d'une nouvelle ère. Experts français et américains débattent des défis politiques, économiques et militaires des États-Unis entre isolationnisme et expansionnisme. - réalisation : Emily Vallat - invités : Denis Lacorne Politiste, directeur de recherche au Centre de Recherches Internationales (CERI) de Sciences Po. Auteur notamment de Les Frontières de la tolérance, Gallimard, 2016.; Pierre Melandri Historien, professeur émérite des universités à Sciences Po; Hervé Coutau-Bégarie; Michel Aglietta Professeur émérite à l'université Paris-Ouest et conseiller scientifique au CEPII et à France Stratégie. Il a été membre de l'Institut universitaire de France et membre du Haut Conseil des finances publiques.; Antony Blinken Ancien secrétaire d'état adjoint des Etats-Unis pendant la présidence Obama; Stanley Hoffmann Professeur de sciences politiques à Harvard
Part of a daily deluge of connected episodes this week to honor the goddess, my Life Path 8 and Pisces
O Glorious Shekhinah! To conclude our two-part special on Caves of Qud, we turn our focus from the epic storyline to the deep gameplay mechanics and systems from the Salt Dunes of the west to the Deep Jungle in the east. Join us for a water ritual on how to negotiate with camel merchants before we clone them, managing our reputation with fuedal fungal lords, and how to navigate the differences between mutated humans, psychic warriors, and just straight-up cyborgs. Get those schematics ready as we disassemble one of the densest and deepest “traditional” “roguelike” games out there. You can find the in depth tutorial series we did with BigSimple to learn this massive game here! Custom RSS Apple Podcasts Spotify YouTube Music Transcript 3:44 - Game stats 7:47 - One sentence description 08:09 - Gamma World tabletop RPG comparison 10:08 - Initial bouncing off & polish improvements 14:23 - Tutorial mode & learning curve discussion 19:31 - Character creation & mutation systems 24:48 - Story structure & main quest overview 29:17 - Death mechanics & permadeath options 34:52 - Open world exploration & procedural generation 40:15 - Village generation & faction systems 45:38 - Combat mechanics & weapon variety 51:22 - Skill tree & ability customization 56:47 - Water economy & trade systems 1:02:08 - Equipment & artifact identification 1:07:45 - Mutation system depth & combinations 1:13:31 - Enemy variety & creature encounters 1:19:03 - Interface improvements & accessibility features 1:24:38 - Save system exploits discussion 1:30:15 - Community & modding ecosystem 1:35:52 - Writing quality & atmospheric storytelling 1:41:27 - Endgame content & difficulty scaling 2:07:27 - Rankings & final thoughts 2:25:15 - Similar games & show wind-down Next episode: Diablo Contact us at grogpodzone@gmail.com! https://grogpod.zone Intro music: Caves of Qud OST - Soundscape I Outro music: Caves of Qud OST - Onward Romantique / Live and Drink
Avant d'être un art, le hip-hop a été une réponse.Une manière de dire “je suis là” quand plus personne ne voulait écouter.Né dans les rues du Bronx au début des années 1970, le mouvement s'est d'abord exprimé au sol, dans la force brute du breakdance — une danse de défi, d'énergie et de survie.Mais pendant que les corps tournaient sur le bitume new-yorkais, une autre révolution se préparait sur la côte ouest : celle des danses debout.À Los Angeles, Don Campbell invente le locking ; à Fresno, Boogaloo Sam crée le popping avec les Electric Boogaloos ; dans la Bay Area, les danseurs de boogaloo font du mouvement un langage poétique.Ces styles, plus musicaux et expressifs, donneront naissance au waacking, à la house dance et au hip-hop freestyle,ouvrant un nouveau chapitre de l'histoire du corps.Arrivé en France dans les années 1980 grâce à l'émission H.I.P H.O.P animée par Sidney, le hip-hop devient un terrain d'expression pour toute une génération.Et c'est au début des années 2000 que Bruce Ykanji rend hommage à ces danses debout en leur offrant enfin une scène mondiale : le Juste Debout.Dans cette capsule, on revient sur cette double histoire —celle des danseurs au sol et de ceux qui se tiennent debout.Deux gestes, deux postures, un même message :celui d'un corps qui refuse de plier.
Il a fait du Juste Debout un phénomène mondial.Mais derrière les battles, les projecteurs et les milliers de danseurs venus du monde entier, il y a un homme lucide et passionné : Bruce Ykanji.Fondateur du plus grand événement de danses hip-hop debout, créateur de la Juste Debout School et entrepreneur infatigable, Bruce continue, plus de vingt ans après, à faire rayonner la culture hip-hop dans toute sa diversité.
durée : 00:04:38 - Le Reportage de la rédaction - En 2007, deux ans après la mort de Zyed et Bouna à Clichy-sous-Bois, Farid Zerzour, alors jeune comédien, décide de lancer son théâtre au cœur du quartier prioritaire dont il est originaire, celui des Fossés-Jean, à Colombes, dans les Hauts-de-Seine. Depuis, il y accueille les habitants.
durée : 00:04:38 - Le Reportage de la rédaction - En 2007, deux ans après la mort de Zyed et Bouna à Clichy-sous-Bois, Farid Zerzour, alors jeune comédien, décide de lancer son théâtre au cœur du quartier prioritaire dont il est originaire, celui des Fossés-Jean, à Colombes, dans les Hauts-de-Seine. Depuis, il y accueille les habitants.
durée : 00:04:40 - Le Reportage de la rédaction - Les émeutes de 2005 avaient entraîné une redéfinition de la politique de la ville. Depuis dix ans, l'objectif est de réduire les écarts entre les 1 400 quartiers prioritaires de la ville et les autres quartiers des agglomérations. Quel bilan ? Reportage à Melun, dans le quartier de l'Almont.
In metastatic breast cancer, resistance to therapy remains one of the most challenging aspects to care. A key driver of resistance in hormone receptor-positive, HER2-negative disease is the ESR1 mutation, a genetic change that alters the estrogen receptor and limits the effectiveness of certain standard therapies. In this episode, CANCER BUZZ speaks with Eleonara Teplinsky, MD, FASCO, head of breast and gynecologic medical oncology at Valley-Mount Sinai Comprehensive Cancer Care, about how the ESR1 mutation shapes treatment decisions and explains communication strategies, such as the "lock-and-key" model. Then CANCER BUZZ speaks with Maimah Karmo, president and CEO of Tigerlily Foundation about the importance of communicating with patients in ways that foster clarity and compassion through relatable analogies. Guest: Eleonora Teplinsky, MD, FASCO Medical Oncologist Valley Mount Sinai Comprehensive Cancer Care Paramus, NJ Maimah Karmo President/CEO Tigerlily Foundation "If you had molecular testing of your tumor done at the time of diagnosis, that may not be enough. If there is disease progression, we might need to repeat it. So it's really important to stress that there are points in the disease course where we're going to be checking for these biomarkers." - Teplinsky "The more that we can know about the tumor, how it's going to behave, what treatment it may or may not respond to, really can help us." - Teplinsky "Having a physician that is a true partner with the patient, that has a relationship, that's trusted, and that feels safe and secure, it's really, really critical." - Karmo Resources: Unlocking the Conversation: Navigating ESR1 Mutations in Metastatic Breast Cancer
durée : 00:04:48 - Le Reportage de la rédaction - La représentation des quartiers populaires dans les médias traditionnels a toujours suscité des crispations chez les habitants et de la colère. En 2005, après la mort de Ziyed et Bouna, de nouveaux acteurs ont émergé ainsi qu'un nouveau récit. Mais la défiance reste profondément ancrée.
✨✨ If you've been wondering what your Incarnation Cross really means, and how it ties into the themes showing up in your life right now, I'd love for you to join me for Incarnation Cross Unlocked on Sunday, November 9th.It's a live workshop where we'll look at how your cross reveals the energetic story you're here to live and what it's trying to express through you.Early bird registration closes November 2nd at midnight, so if this feels like a yes, now's the time to grab your spot:https://tinyurl.com/54zm7ms5___________________________________________________________________________November brings a real shift in tone. We're leaving the tribe-centered Quarter of Duality and stepping into the Quarter of Mutation — the part of the cycle that's all about individuality, creativity, and inner transformation.In this episode, Hali and I look at what that means through the Sun and Earth transits for the month. It's a time when things start to feel a little different — like change is brewing under the surface, and something new is waiting to take shape.We also touch on how individuality doesn't mean doing it all alone. It's more about learning to trust what's uniquely yours, even if no one else sees it yet.If you've been feeling restless or like you're on the edge of something new (but can't name it yet), this episode will make a lot of sense.Chapters00:00 Introduction and Announcements04:40 Upcoming Workshop and Human Design Education09:30 Protests and Civic Engagement14:03 November Transits Overview18:45 Sun Gate 1 Earth Gate 227:43 Trusting Your Inner Guidance31:26 Sun Gate 43 Earth Gate 2336:42 Understanding the Genius to Freak Channel46:42 Sun Gate 14 Earth Gate 859:24 Sun Gate 34 Earth Gate 2001:00:42 Manifesting Generators and Their Energy01:10:39 Sun Gate 9 Earth Gate 1601:12:55 Collective Energies and Mastery01:16:18 Balancing Enthusiasm and Mastery01:20:35 Quality Over Quantity: The Importance of Focus01:22:04 Embracing Your Unique Contribution01:22:51 Transit Wrap Up01:23:47 Incarnation Cross of the Week01:28:05 Wrap Up Get new episodes (and bonuses) delivered straight to your inbox! https://danaphillips.substack.com/Tired of fighting your own energy? Your Human Design for Energetic Clarity guidebook translates your Human Design into practical wisdom so you can stop forcing what doesn't work and start living what does. Grab yours here: https://www.humandesignhive.com/guidebookWant insight on your design, on your time? Check out the customized Audio Human Design Reading: https://www.humandesignhive.com/audio_readingGrab your FREE copy of your Human Design chart (Bodygraph) Here: https://www.humandesignhive.com/freechartWebsite: https://www.humandesignhive.comemail: Dana@humandesignhive.com This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit danaphillips.substack.com/subscribe
Straight-shot riff from the alchemist's mic.In this unscripted Cosmic Brew quickie, I drop in the day before Halloween—right as Mercury hits 0° Sagittarius opposing Uranus at 0° Gemini—to mark the "endingish" of the four-year Channel of Mutation and the opening of a brand-new creative cycle.We talk:A big thing happening today we will never see again in our life and what it matters for your future lifeWorking with the unseen realms now and in the futureWhat Mercury entering Sagittarius has to do with all thisWhy intuition—not algorithms—is the real business strategy Other:Episodes Referenced from other Pod:Diary of CEO"Kris Jenner" EpisodeThis YT is now @CosmicBrewPodcast. The prior YT channel with older episodes - which is no longer collective astrology focused (is @alignedgold). The brand (formally @successandspirit is now @alignedgold)***1️⃣) My evolutionary shift work (quantum meets evolutionary astrology) will release in November. This link provides you taste of what I do and my results:***2️⃣) My Clarity by Design Sessions: (Human Design informed life/business strategy) ⬇️This is the link in case the arcane podcast "notes formatting": doesn't work: https://cal.com/alignedgold/clientsession***3️⃣) My 1-1 business strategy work is booked through 2025. I will open up slots in 2026. I will notify my email list first.
Thème du jour : la télévision française face aux plateformes digitales.Au programme : comprendre comment les chaînes traditionnelles réinventent leur modèle face à la concurrence,analyser l'impact des plateformes sur l'investissement publicitaire, et débattre de l'avenir de l'écosystème TV français dans ce nouvel environnement.Une émission spéciale qui regroupe les experts et journalistes du groupe influencia.Julia Luczak-Rougeaux (Rédactrice en chef de Minted)Philippe Bailly (Fondateur de NPA Conseil)Cyrille Frank (Directeur des rédactions d'Influencia et de Minted) Hébergé par Acast. Visitez acast.com/privacy pour plus d'informations.
Pourquoi et comment transformer sa posture intérieure dans un monde en mutation ?J'ai le plaisir de recevoir Stéphane Riot, coach de dirigeant et consultant en transformation des organisations, mais il se présente plutôt comme Alchimiste des organisations , car il explore et accompagne, depuis plus de vingt ans, les transformations profondes des entreprises et des individus à travers une approche puissante et originale qui tisse des ponts entre le rationnel et le subtil, entre les modèles d'organisation nouveaux (dits " régénératifs") et la sagesse des traditions universelles et du symbolique, tout cet univers au service des dirigeants et de leurs équipes pour les aider à traverser leurs métamorphoses "en conscience" de ce qui se passe dans l'invisible de leur organisation.Dans cet épisode, nous explorons ce que signifie être un leader conscient — non pas seulement dans le monde professionnel, mais dans la façon dont nous vivons, décidons et entrons en relation. Nous verrons comment cultiver cette présence intérieure peut transformer notre manière d'être au monde.Vous pouvez retrouver Stéphane Riot :- Site : www.noveterra.com- LinkedIn : https://www.linkedin.com/in/stephaneriot/Bonne écoute !------------------------------------------------------------------------------------------------------------------------------------------Si vous avez apprécié cet épisode, et que vous souhaitez soutenir gratuitement le podcast, n'hésitez pas laisser 5 étoiles et un commentaire sur Apple podcast
durée : 00:04:40 - Le Reportage de la rédaction - La mort de Zyed et Bouna avaient fait émerger le terme de "violences policières" même si les deux policiers ont été définitivement relaxés. Vingt ans plus tard, l'expression n'est pas reconnue comme une catégorie par les autorités mais une association témoigne de la vitalité du débat.
In this episode of JCO PO Article Insights, host Dr. Jiasen He summarizes the article, "Somatic Mutation Profiles of Colorectal Cancer by Birth Cohort" by Gilad, et al published October 11, 2025. TRANSCRIPT Jiasen He: Hello, and welcome to the JCO Precision Oncology Article Insights. I am your host, Jiasen He, and today, we will be discussing the JCO Precision Oncology article, "Somatic Mutation Profiles of Colorectal Cancer by Birth Cohort," by Dr. Gilad and colleagues. Early-onset colorectal cancer is defined as colorectal cancer diagnosed before the age of 50. Several reports have suggested that early-onset colorectal cancer has unique characteristics. Compared with late-onset colorectal cancer, early-onset colorectal cancer cases are more commonly found in the distal colon or rectum, tend to be diagnosed at more advanced stages, and may display unfavorable histologic features. Although the overall incidence of colorectal cancer has declined in recent decades, the incidence of early-onset colorectal cancer continues to rise. This increase appears to be driven by birth cohort effects. The reasons behind this rise remain unclear but are likely multifactorial, involving changes in demographics, diet, lifestyle, environmental exposures, and genetic predisposition. At the same time, studies have shown conflicting results regarding whether there are differences in the mutation profiles between early-onset and late-onset colorectal cancer. Therefore, it is crucial to explore whether colorectal cancer somatic mutational landscape differs across birth cohorts, as this could provide important insight into generational shifts in colorectal cancer incidence. To address this question, the authors conducted a retrospective study to characterize the mutation spectrum of colorectal cancer across different birth cohorts. Consecutive colorectal cancer patients who underwent somatic next-generation sequencing at the University of Chicago pathology laboratory between 2015 and 2022 were retrospectively identified. Tumors were tested for 154 to 168 genes and categorized as either microsatellite stable or high according to established thresholds. Patients with hereditary cancer syndromes or inflammatory bowel disease were excluded. Participants were then grouped into birth cohorts by decades, as well as into two major groups: those born before 1960 and after 1960. Genes that were identified in at least 5% of the sample were selected and grouped into 10 canonical cancer signaling pathways. These genes and pathways were then included in the analysis to explore their association with colorectal cancer across different birth cohorts and age groups. A total of 369 patients were included in the study, with a median birth year of 1955 and a median age at colorectal cancer diagnosis of 62.9 years. 5.4% were identified as having microsatellite-high tumors. The median tumor mutational burden was 5 mutations per megabase for microsatellite-stable tumors and 57.7 mutations per megabase for microsatellite-high tumors. Patients with microsatellite-high tumors tended to have earlier birth years and were diagnosed at an older age. However, after adjusting for potential confounders, neither birth year nor age remained statistically significant. Similarly, after controlling for confounders, no significant associations were observed between birth year or age and mutation burden. In this cohort, APC, TP53, and KRAS were the most frequently mutated genes. No statistically significant differences in the prevalence of gene mutations were observed across birth cohorts. Correspondingly, the most affected signaling pathways were the Wnt, TP53, and (RTK)/RAS pathways. Similar to the gene-level finding, no significant differences in the prevalence of these pathways were identified among birth cohorts. When examining patients born before and after 1960, the authors found that the older birth cohorts were diagnosed at an older age and had higher tumor mutational burden. However, no significant differences were observed in any of the genes or pathways analyzed. Among microsatellite-stable tumors, 18.3% were classified as early-onset colorectal cancer, while 81.1% were late-onset colorectal cancer. Consistent with previous reports, early-onset colorectal cancers in this cohort were more likely to be left-sided and more common among more recent birth cohorts. However, no significant differences were identified in any of the examined genes or pathways when comparing early-onset to late-onset colorectal cancer. In this cohort, a higher prevalence of early-onset colorectal cancer was observed among more recent birth cohorts, consistent with previous reports. Still, no distinct mutational signature was identified between the early and late birth cohorts. The authors proposed that the lack of distinct mutational profile by age or birth cohort may be due to the limited number of key molecular pathways driving colorectal cancer. Although environmental exposures likely differ across generations, the downstream effects may have converged on similar biological mechanisms, leading to comparable somatic mutations across cohorts. Alternately, they proposed that the observed birth cohort differences in colorectal incidence may be driven by distinct mutation signatures, epigenetic alterations, or changes in the immune microenvironment rather than variations in canonical gene mutations. As the authors noted, given the retrospective nature of this study, its modest sample size, and the predominance of advanced-stage tumors, larger prospective studies are needed to validate these findings. In summary, this study found no significant differences in the mutational landscape of colorectal cancer across birth cohorts or age groups. The authors proposed that the generational shift in colorectal cancer incidence is unlikely to be driven by changes in the underlying tumor genomics. However, larger prospective studies are needed to validate these findings. Thank you for tuning in to JCO Precision Oncology Article Insights. Do not forget to subscribe and join us next time as we explore more groundbreaking research shaping the future of oncology. The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement.
Et si la danse n'était pas seulement un art,mais une manière de prendre soin ?À l'occasion d'Octobre Rose,cette capsule d'Un pas de côté explore un territoire où le mouvement rencontre la guérison, où le corps, parfois blessé, retrouve sa force à travers le geste.Depuis plusieurs années, la médecine reconnaît l'importance des soins de support :ces approches qui accompagnent les traitements du cancer et aident à mieux vivre la maladie.Parmi elles, la danse se distingue.Elle agit sur la fatigue, sur le moral, sur la confiance.Elle apaise, libère, reconnecte.Dans cette capsule, la journaliste Myriam Sellam interroge le pouvoir thérapeutique du mouvement :comment danser peut soulager,comment bouger peut réaccorder ce que la maladie a séparé.Des études menées dans le monde entier montrent que la danse-thérapie réduit le stress,améliore l'équilibre, la mobilité et la qualité de vie.Mais au-delà des chiffres, il y a ce que disent les femmes.Comme Muriel, qui confie :“On ne vit pas avec la maladie sans soins de support.Et pour moi, la danse en est un, très important.”À travers son témoignage et ceux recueillis dans l'association Elles dansent,cette capsule raconte la force du collectif,la beauté du mouvement partagé,et la tendresse des corps qui reprennent confiance.Ici, il n'est pas question de prouesse ni de technique,mais d'écoute, de respiration, de présence.La danse devient un espace de soin invisible,un langage qui réconcilie le corps et l'esprit,un souffle qui rappelle que la vie continue de circuler — même dans la fragilité.—
durée : 00:04:56 - Le Reportage de la rédaction - Le 27 octobre 2005, deux adolescents de Clichy-sous-Bois mouraient électrocutés après une course poursuite avec la police. Suivront 3 semaines d'affrontements avec les forces de l'ordre, dans plus de 300 villes de France. Vingt ans après, la colère des jeunes est empoignée par leurs mères.
This week, Professor Jan Vijg joins us to discuss the intricate relationship between DNA mutations, epigenetic drift, and aging. He explains the differences between mutations and epigenetic changes, the role of environmental factors, and the potential for reversing epigenetic changes. The conversation also touches on the implications of somatic mutations and the future of longevity research, particularly in relation to DNA repair mechanisms. Learn more about Professor Jan Vijg: https://einsteinmed.edu/faculty/11318/jan-vijg - Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0 Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com
durée : 00:04:22 - Le Reportage de la rédaction - En 2005, trois semaines de violences embrasent la France. À l'époque, les habitants des quartiers se mobilisent pour tenter d'apaiser la situation. Une démarche politique, mais vingt ans plus tard, que reste-t-il de cet engagement citoyen dans les quartiers populaires ?
In this bright and refreshing episode, Janina travels to the shores of Lake Garda to uncover one of Italy's most exciting and underrated white wine regions - Lugana DOC. Her guest is Fabio Zenato, president of the Consorzio Tutela Lugana DOC, who brings three generations of family knowledge and a deep passion for the local Turbiana grape. Together, they explore the true identity of Turbiana, the unique glacial soils of the region, and why Lugana wines can age far beyond expectations. Expect insights into clonal selection, microclimate, and terroir - all wrapped in stories of tradition, elegance, and discovery. Shownotes [01:53] Third-generation vintner Fabio Zenato reflects on childhood memories that shaped his connection to the vineyards of Lugana. [02:28] Family heritage and early experiences that inspired a lifelong dedication to the land and its vines. [04:46] Clarifying the genetic confusion surrounding the Turbiana grape and its historical misidentification. [04:57] Understanding the DNA difference between Turbiana, Verdicchio, and Trebbiano di Soave. [09:18] Mutation or clone — exploring how proximity to Soave influenced Turbiana's evolution. [10:41] Labeling inconsistencies and the importance of protecting the Turbiana name. [12:04] Tasting Tommasi Le Fornaci 2024 (£19.99 Cambridge Wine Merchants) and what to expect from a fresh, mineral-driven Lugana wine. [14:40] Locating Lugana: the southern shores of Lake Garda, between Lombardy and Veneto. [19:27] The influence of Lake Garda's breezes and surrounding topography on vineyard climate. [20:33] The role of elevation - from 60 to 100 meters - and how slight altitude differences affect freshness and balance. [22:02] Exploring Monte Lupo 2015 from Cobue and understanding why Turbiana has remarkable aging potential. [24:47] How Lugana wines maintain acidity and evolve with nutty, floral, and mineral complexity over time. [27:40] Introducing La Rifra Riserva 2022 - structure, richness, and longevity in the glass. £24.99 D Vino Wines [28:53] Defining what makes a Lugana Riserva: minimum aging, depth, and stylistic differences. [32:53] The story behind Benedictus 2023 from Le Morette — the philosophy and inspiration behind its name. £22 The Wine Rack [34:41] Winemaking approach: lees aging, oak influence, and the balance between richness and minerality. [38:05] Food pairing ideas — from seafood to risotto, and how Lugana's texture makes it versatile. [40:05] Tasting Feliciana 'Serce' Riserva 2022 — €27.95 Woodberrys.ie [40:36] Travel tips: flying into Verona for the easiest route to Lugana and Lake Garda. [42:59] Must-try local dishes and regional specialties to pair with Turbiana wines. [45:28] A new generation of winemakers bringing innovation through sparkling and sweet styles. [46:50] Corte Sermana Duerive 2023 — bright, delicate, and grown by the lake, where the vines feel the breeze off Garda's shores. [49:07] The perfect Lugana moment — sunshine, lake views, and a chilled glass of Turbiana.
durée : 00:04:40 - Le Reportage de la rédaction - La mort de Zyed et Bouna avaient fait émerger le terme de "violences policières" même si les deux policiers ont été définitivement relaxés. Vingt ans plus tard, l'expression n'est pas reconnue comme une catégorie par les autorités mais une association témoigne de la vitalité du débat.
durée : 00:04:56 - Le Reportage de la rédaction - Le 27 octobre 2005, deux adolescents de Clichy-sous-Bois mouraient électrocutés après une course poursuite avec la police. Suivront 3 semaines d'affrontements avec les forces de l'ordre, dans plus de 300 villes de France. Vingt ans après, la colère des jeunes est empoignée par leurs mères.
durée : 00:04:40 - Le Reportage de la rédaction - Les émeutes de 2005 avaient entraîné une redéfinition de la politique de la ville. Depuis dix ans, l'objectif est de réduire les écarts entre les 1 400 quartiers prioritaires de la ville et les autres quartiers des agglomérations. Quel bilan ? Reportage à Melun, dans le quartier de l'Almont.
durée : 00:04:48 - Le Reportage de la rédaction - La représentation des quartiers populaires dans les médias traditionnels a toujours suscité des crispations chez les habitants et de la colère. En 2005, après la mort de Ziyed et Bouna, de nouveaux acteurs ont émergé ainsi qu'un nouveau récit. Mais la défiance reste profondément ancrée.
durée : 00:04:22 - Le Reportage de la rédaction - En 2005, trois semaines de violences embrasent la France. À l'époque, les habitants des quartiers se mobilisent pour tenter d'apaiser la situation. Une démarche politique mais vingt ans plus tard, que reste-t-il de cet engagement citoyen dans les quartiers populaires ?
durée : 00:01:24 - Le Reportage de la rédaction - Il y a vingt ans, Zyed et Bouna, deux adolescents de Clichy-sous-Bois mourraient lors d'une course poursuite avec des policiers. Ce drame avait provoqué la colère des jeunes des quartiers populaires et 3 semaines de violences, dans près de 300 villes de France. Cette colère n'a pas disparu.
Nous sommes en octobre.Partout en France, le rose s'affiche sur les façades, les affiches, les vêtements.Il symbolise la lutte, la solidarité, l'espoir.Ce soir, à la mairie du 3ᵉ arrondissement de Paris, ce message prend une autre forme : il se danse.Dans les coulisses, quatre femmes se préparent.Les rires se mêlent aux gestes du trac.On ajuste une robe, on vérifie une mèche, on respire.Sur scène, elles danseront avec leur professeure Aurélie Lili Boo, au sein de l'association Elles dansent, fondée par Aude Michon.Une association qui accompagne, à travers la danse, des femmes touchées par le cancer.Ici, pas de miroir pour juger.Pas de quête de perfection.Seulement des corps qui se réapprivoisent, des visages qui se relèvent,des gestes qui reprennent confiance.J'ai posé mon micro dans les coulisses, au plus près de leurs voix, de leurs rires, de leurs silences aussi.Ensemble, nous avons partagé ce moment suspendu où la vie, pour un instant, reprend le dessus.Muriel, Sylvia, Régine et Emmanuelle racontent leur rapport au corps, à la féminité, à la maladie, mais surtout à la joie d'être ensemble.Dans chaque mouvement, il y a une victoire intime.Ce reportage est une traversée — de la fatigue à la lumière, de la peur à la fierté, du corps contraint au corps dansant.Une parenthèse pour célébrer la force tranquille de celles qui continuent d'avancer.—
Le français vacille-t-il sous les anglicismes, emojis et textos ? Puristes ou enthousiastes s'affrontent : déclin ou renaissance ? Une chose est sûre, la langue change - vive, audacieuse, en pleine mutation. Avec : - Anne Abeillé, professeur de linguistique à l'Université Paris Cité, autrice de La Grande Grammaire du français, éditions Actes Sud, membre du Collectif des linguistes atterré(e)s- Bénédicte Pivot, enseignante-chercheuse en sociolinguistique à l'université Paul-Valéry-Montpellier, autrice du livre Langues et précarités, éditions des archives contemporaines- Gilles Siouffi, professeur à Sorbonne Université et spécialiste de la langue française des XVIIe et XVIIIe siècle, auteur de Paris-Babel - Histoire linguistique d'une ville-mondes, éditions Actes Sud, membre du Collectif des linguistes atterré(e)sRetrouvez tous nos contenus, articles et épisodes sur rcf.frSi vous avez apprécié cet épisode, participez à sa production en soutenant RCF.Vous pouvez également laisser un commentaire ou une note afin de nous aider à le faire rayonner sur la plateforme.Retrouvez d'autres contenus d'économie et société ci-dessous :Silence, on crie : https://audmns.com/jqOozgUOù va la vie ? La bioéthique en podcast : https://audmns.com/UuYCdISContre courant : https://audmns.com/swImDAMAu bonheur des herbes : https://audmns.com/XPVizmQSacré patrimoine : https://audmns.com/TNJhOETEnfin, n'hésitez pas à vous abonner pour ne manquer aucun nouvel épisode.À bientôt à l'écoute de RCF sur les ondes ou sur rcf.fr !Hébergé par Audiomeans. Visitez audiomeans.fr/politique-de-confidentialite pour plus d'informations.
Der Ausbruch der Vogelgrippe trifft in Deutschland vor allem Kraniche. Grund könnte eine fehlende Herdenimmunität für eine besondere Mutation des H5N1-Viruses sein. Doch auch andere Vögel sind betroffen. Menschen sollten ebenfalls vorsichtig sein. Brose, Maximilian www.deutschlandfunk.de, Forschung aktuell
« Gender reveal », « professional baby namer », « funeral planner »… Entre nouveaux métiers et évènements taillés surmesure pour les réseaux sociaux, les Etats-Unis s'imposent comme le laboratoire des tendances les plus étonnantes, voire les plus absurdes, dans la mise en scène et la commercialisation des moments de vie. Mention légales : Vos données de connexion, dont votre adresse IP, sont traités par Radio Classique, responsable de traitement, sur la base de son intérêt légitime, par l'intermédiaire de son sous-traitant Ausha, à des fins de réalisation de statistiques agréées et de lutte contre la fraude. Ces données sont supprimées en temps réel pour la finalité statistique et sous cinq mois à compter de la collecte à des fins de lutte contre la fraude. Pour plus d'informations sur les traitements réalisés par Radio Classique et exercer vos droits, consultez notre Politique de confidentialité.Hébergé par Ausha. Visitez ausha.co/politique-de-confidentialite pour plus d'informations.
Join The Deep Dive(Life-changing teachings for spiritual mastery, guided sound journeys, and access to live community gatherings to share your most authentic self) https://iamemilioortiz.com/the-deep-d...In this visionary interview, Richard Rudd — creator of the Gene Keys — joins Emilio Ortiz to explore one of the most profound themes in human evolution: the path of love, commitment, and transformation. Together they dive deep into Gene Key 29, which emphasizes the importance of surrendering to the heart's journey, even when faced with uncertainty. This dialogue weaves together the mysteries of DNA mutations, collective healing, and Gaia's awakening, offering a rare glimpse into the birth of the future human. Beyond the teachings of the Gene Keys, Emilio and Richard reflect on the contrasts between the creative process and AI, highlighting how technology can accelerate output but often lacks the depth of authentic human creativity. This episode illuminates the possibilities of a coming epoch where Gaia and humanity evolve together, where DNA mutations may spark new potentials, and where each of us is invited to become a living expression of infinity, wisdom, and awakening.Over the past several decades, Richard has dedicated his life to unraveling the mysteries of human consciousness and evolution, and from his initial download at 29, has developed a unique and transformative system for unlocking human potential using the power of the Gene Keys. Through his books, workshops, and online courses, Richard has helped countless individuals around the world to awaken to their true potential and discover their life's purpose. The Gene Keys is a system of spiritual and personal growth that draws on a variety of wisdom traditions, including astrology, human design, the I Ching, and the Kabbalah. At its core, the Gene Keys is a map of human consciousness that helps individuals to unlock their highest potential and transcend the limitations of their past conditioning. Join Richard Rudd for his upcoming London event (2025)
In this episode we connect genetics + central dogma to the next big step: how cells copy DNA and what happens when it goes wrong.What you'll learn (MCAT-high yield):Semi-conservative replication: why each daughter DNA has one old + one new strandOrigins of replication & replication bubblesKey enzymes: helicase, SSB proteins, topoisomerase, DNA pol III & I, primase, ligaseLeading vs. lagging strands and Okazaki fragmentsProofreading & repair: exonuclease activity, mismatch repair, nucleotide excision repair (UV/thymine dimers)Mutation types: silent, nonsense, frameshift (+ why location matters)Where this shows up in cell cycle, cancer biology, and classic experimental set-ups (knockouts)Perfect for MCAT Bio/Biochem passages that love replication, mutations, and repair pathways.Want to learn more? Shoot us a text at 415-855-4435 or email us at podcast@jackwestin.com!
Aujourd'hui, Didier Giraud, éleveur de bovins, Charles Consigny, avocat, et Flora Ghebali, entrepreneure dans la transition écologique, débattent de l'actualité autour d'Alain Marschall et Olivier Truchot.
Host: Charles Turck, PharmD, BCPS, BCCCP Guest: Sarah Sammons, MD About 40 percent of patients with metastatic HR+/HER2- breast cancer have an activating mutation in the PIK3CA gene,1,2 which plays a key role not only in tumor growth, but also in driving resistance to endocrine therapy.3-5 And while there are several FDA-approved PI3K pathway-targeted agents for patients with PIK3CA tumor mutations,6-8 they come with challenges, like modest efficacy and on-pathway effects.9-12 Given this unmet need, the ReDiscover trial evaluated the investigational agent RLY-2608 in combination with fulvestrant in in patients with PIK3CA-mutated HR+/HER2- aBC previously treated with a CDK4/6 inhibitor.13 Joining Dr. Charles Turck to share updated safety and efficacy data from the trial is Dr. Sarah Sammons, a Senior Physician at the Dana-Farber Cancer Institute and an Assistant Professor of Medicine at Harvard Medical School in Boston. References: Vasan N, Cantley LC, Vasan N, Cantley LC. At a crossroads: how to translate the roles of PI3K in oncogenic and metabolic signalling into improvements in cancer therapy. Nat Rev Clin Oncol. 2022;19(7):471-485. doi:10.1038/s41571-022-00633-1 Network TCGA. Comprehensive molecular portraits of human breast tumours. Nature. 2012;490(7418):61-70. doi:10.1038/nature11412 Saal LH, Johansson P, Holm K, et al. Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor …
Avant d'être une icône mondiale, le hamburger était un sandwich de rue. Né il y a plus de 135 ans aux États-Unis, ce sandwich simple en apparence raconte une histoire bien plus complexe : celle de la mondialisation et des mutations de nos habitudes alimentaires. Plaisir coupable pour les uns, fétiche réinventé pour les autres, le burger unit toutes les générations et dit beaucoup de nos sociétés. Yasmine Boudaka évoque l'histoire d'un des symboles culinaires américains avec Pierre Leclercq, historien de l'alimentation et auteur du Petit traité du burger, paru aux Éditions du Sureau. Sujets traités : burger, sandwich, États-Unis, mondialisation , mutations, Merci pour votre écoute Un Jour dans l'Histoire, c'est également en direct tous les jours de la semaine de 13h15 à 14h30 sur www.rtbf.be/lapremiere Retrouvez tous les épisodes d'Un Jour dans l'Histoire sur notre plateforme Auvio.be :https://auvio.rtbf.be/emission/5936 Intéressés par l'histoire ? Vous pourriez également aimer nos autres podcasts : L'Histoire Continue: https://audmns.com/kSbpELwL'heure H : https://audmns.com/YagLLiKEt sa version à écouter en famille : La Mini Heure H https://audmns.com/YagLLiKAinsi que nos séries historiques :Chili, le Pays de mes Histoires : https://audmns.com/XHbnevhD-Day : https://audmns.com/JWRdPYIJoséphine Baker : https://audmns.com/wCfhoEwLa folle histoire de l'aviation : https://audmns.com/xAWjyWCLes Jeux Olympiques, l'étonnant miroir de notre Histoire : https://audmns.com/ZEIihzZMarguerite, la Voix d'une Résistante : https://audmns.com/zFDehnENapoléon, le crépuscule de l'Aigle : https://audmns.com/DcdnIUnUn Jour dans le Sport : https://audmns.com/xXlkHMHSous le sable des Pyramides : https://audmns.com/rXfVppvN'oubliez pas de vous y abonner pour ne rien manquer.Et si vous avez apprécié ce podcast, n'hésitez pas à nous donner des étoiles ou des commentaires, cela nous aide à le faire connaître plus largement. Hébergé par Audiomeans. Visitez audiomeans.fr/politique-de-confidentialite pour plus d'informations.
Nels and Vincent discuss research which shows a shift from the rule that living organisms produce same-species offspring: an ant that produces individuals from two distinct species. Hosts: Nels Elde and Vincent Racaniello Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiEVO Links for this episode Join the MicrobeTV Discord server David Baltimore interview (TWiV 100) One mother for two species (Nature) Timestamps by Jolene Science Picks Nels – Dr. Bill Rom, NYU canoes every lake connected by a portage trail in the Boundary Waters in Minnesota Vincent – Google just made photography obsolete Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twievo@microbe.tv
This YT is now @CosmicBrewPodcast. The prior YT channel with older episodes - which is no longer collective astrology focused (is @alignedgold). The brand (formally @successandspirit is now @alignedgold)***1️⃣) My evolutionary shift work (quantum meets evolutionary astrology) will release in November. This link provides you taste of what I do and my results:***2️⃣) My Clarity by Design Sessions: (Human Design informed life/business strategy) ⬇️This is the link in case the arcane podcast "notes formatting": doesn't work: https://cal.com/alignedgold/clientsession***3️⃣) My 1-1 business strategy work is booked through 2025. I will open up slots in 2026. I will notify my email list first. Snakes, butterflies, Channel of Mutation, Why everyone is so weird right now, Kali, Karma, Saturn, Life Path 8, Taking Power in the World, MoneyThread Post Mentioned Link:In this fiery episode of Cosmic Brew: The Astrology of Power, Cycles, and Collective Evolution, Sunita dives straight into the raw conversation on power, money, and feminine archetypes—no filters, no fluff.Venus may have crossed into Libra, but it's Pluto and Kali who take center stage. From Saturn's karmic lessons to the shadow side of the spiritual industry, Sunita unpacks the difference between embodying the divine and serving it.Expect sharp riffs on:Why Kali isn't a brand persona—and what happens when people treat Her like oneThe difference between consequence and karma (and how Western culture gets it wrong)How Saturn and Pluto define modern power—and why women mastering the material plane is a spiritual actSnakes, shedding, and butterflies as metaphors for our collective transformationThe next six months of energetic recalibration as we approach the final Human Design New Year before the Cross of the Sleeping PhoenixPlus, Sunita shares a behind-the-scenes story from Threads that proves why you don't mess with The Goddess.
On this week's episode, Josh and Michael exchange the established treatment landscape of EGFR and ALK mutant NSCLC for the developing management of disease harbouring KRAS and MET mutations. The most common mutation meets one of the least common in this battle of therapeutic tenacity.Studies discussed in this episode:INSIGHT-2KRYSTAL-12For more episodes, resources and blog posts, visit www.inquisitiveonc.comPlease find us on Twitter @InquisitiveOnc!If you want us to look at a specific trial or subject, email us at inquisitiveonc@gmail.comArt courtesy of Taryn SilverMusic courtesy of AlisiaBeats: https://pixabay.com/users/alisiabeats-39461785/Disclaimer: This podcast is for educational purposes only. If you are unwell, seek medical advice.Oncology for the Inquisitive Mind is recorded with the support of education grants from our foundation partners Pfizer, Gilead Pharmaceuticals and Merck Pharmaceuticals. Our partners have access to the episode at the same time you do and have no editorial control over the content. Hosted on Acast. See acast.com/privacy for more information.
This YT is now @CosmicBrewPodcast. The prior YT channel with older episodes - which is no longer collective astrology focused (is @alignedgold). The brand (formally @successandspirit is now @alignedgold)***1️⃣) My evolutionary shift work (quantum meets evolutionary astrology) will release in November. This link provides you taste of what I do and my results:***2️⃣) My Clarity by Design Sessions: (Human Design informed life/business strategy) ⬇️This is the link in case the arcane podcast "notes formatting": doesn't work: https://cal.com/alignedgold/clientsession***3️⃣) My 1-1 business strategy work is booked through 2025. I will open up slots in 2026. I will notify my email list first. Can you feel the shift? In this raw, real-time reflection recorded on the powerful mirror day 10/10, Sunita unpacks the energetic pivot that marks the end of Pluto's long stay in Gate 60 — and the close of an era of mutation, intensity, and deep internal rewiring.She explores:Why manifestation is accelerating as Uranus moves toward GeminiHow Pluto's station direct triggers an unveiling — the literal meaning of “apocalypse”The difference between Pluto's feminine felt power and Mars' performative fireThe collective integration phase following years of upheavalHow to detox your mind and environment during high-frequency transitsWhy words, rituals, and intention-setting hold amplified power under Mercury in Scorpio and a Virgo MoonThis episode closes the loop on a four-year cycle that began with Cosmic Alarm Clock and sets the tone for what's ahead — a more elegant, distilled Cosmic Brew for the Uranus-in-Gemini era.☕️ Expect truth-telling, catalytic clarity, and insight on how to navigate the final stretch of Gate 60 before everything accelerates.Doing Gemini in Business YoutTube: https://www.youtube.com/watch?v=72eTRd3SsXc&t=64sAlso check out the links below showcasing key milestones in the evolution of this brand — the Rosetta Stone moments that shaped its birth and growth.IG Live Virgo Full Moon 3/2022. Birth of Cosmic Alarm Clock: https://www.instagram.com/tv/CbNtrVyBDZ1/?igsh=c3oyd2x2aHY3eGRjLaunch of the Brand on 8/8/21 on IG:https://www.instagram.com/p/CST6aMmLqEz/?igsh=MTExcTV6anh0cTZkZw==Snake Photo on 11/11/21 on IG:https://www.instagram.com/p/CWmLxLILUzs/?igsh=MTZiNW5ldmZncGJlcQ==Keywords:Pluto Direct 2025, Manifestation in Human Design, Cosmic Brew PodcastExplore Pluto's 2025 station, Uranus in Gemini, and real-world manifestation through Human Design and collective awakening.Pluto Direct 2025, Human Design Gate 60, Uranus in Gemini, manifestation, collective awakening, cosmic shifts, astrology podcast, spiritual transformation, Sunita Kumar, Cosmic Brew
This YT is now @CosmicBrewPodcast. The prior YT channel with older episodes - which is no longer collective astrology focused (is @alignedgold). The brand (formally @successandspirit is now @alignedgold)***1️⃣) My evolutionary shift work (quantum meets evolutionary astrology) will release in November. This link provides you taste of what I do and my results:***2️⃣) My Clarity by Design Sessions: (Human Design informed life/business strategy) ⬇️This is the link in case the arcane podcast "notes formatting": doesn't work: https://cal.com/alignedgold/clientsession***3️⃣) My 1-1 business strategy work is booked through 2025. I will open up slots in 2026. I will notify my email list first. Aries Fire: Misunderstood Pioneers and the Courage to Move Humanity ForwardEvery revolutionary was misunderstood first. Emerson knew it. So did Galileo, Copernicus, and every soul who dared to move humanity forward.In this fiery Aries Full Moon transmission, Sunita channels the spirit of the misunderstood pioneer — the one who climbs before there's a path, speaks before there's consensus, and leads before the world catches up.You'll hear:Why being misunderstood is a hallmark of trailblazers and innovatorsWhat Aries reveals about courage, leadership, and risk-takingHow Neptune's rare movement into Aries sets the tone for a new collective eraThe deeper cycles behind the Sun–Mars conjunctions and Pluto's final pass through Gate 60How the masculine and feminine archetypes are being rewritten in real timeWhy this eclipse season represents — the completion of one evolution and the seeding of the nextSunita also reflects on legacy, receipts, and Saturn's demand for record-keeping — why visibility now isn't about vanity metrics, but about marking the truth in real time.☕️ A potent brew of astrology, history, and unapologetic Aries fire.Aries Full Moon 2025 | Misunderstood Pioneers, Mars in Scorpio & Collective CourageExplore the Aries Full Moon, Mars in Scorpio, and why being misunderstood marks true pioneers in this fiery Cosmic Brew episode.Tags / Keywords:Aries Full Moon, Mars in Scorpio, Pluto Gate 60, Uranus in Gemini, misunderstood pioneers, Human Design, astrology podcast, cosmic awakening, eclipse season, feminine rising, Sunita Kumar, Cosmic Brew, Aries Full Moon, Full Moon in Aries, Neptune in Aries, eclipse season, Mars conjunction, Pluto in Aquarius, astrology, human design, Channel of Mutation, 2026 predictions, Saturn astrology, collective evolution, Saturn in Pisces, Saturn in Aries, Uranus in Gemini, Virgo Eclipse, Pisces Eclipse
REDIFF - Comment communiquer dans le couple lorsque se profile une mutation d'un des conjoints ? Qui est le plus souvent lésé et comment cela peut-il être vécu ? En compagnie de Caroline Dublanche, Paul Delair revient sur les témoignages et autres moments qui ont marqué le direct. Chaque soir, en direct, Caroline Dublanche accueille les auditeurs pour 2h30 d'échanges et de confidences. Pour participer, contactez l'émission au 09 69 39 10 11 (prix d'un appel local) ou sur parlonsnous@rtl.frHébergé par Audiomeans. Visitez audiomeans.fr/politique-de-confidentialite pour plus d'informations.
What if forgetting wasn't failure, but actually part of the learning process? In this episode of Knowledge for Teachers, Brendan Lee sits down with bestselling author and educator Kate Jones to explore what retrieval practice really looks like in the classroom. Kate shares practical strategies for making retrieval a habit, clears up common misconceptions, and shows how small tweaks — from scaffolding questions to giving feedback that sticks — can transform learning. Along the way, you'll hear stories from Kate's own teaching journey, insights from research and creative ideas teachers can use right away. Whether you're just starting out with retrieval or looking to deepen your practice, this episode will leave you with simple, sustainable ways to help knowledge stick and build your students' confidence. Resources mentioned: Why Students Don't Like School — Daniel Willingham Love to Teach — Kate Jones Retrieval Practice series (multiple books) — Kate Jones Retrieval Practice: Myths, Mutations and Mistakes (free ebook, Evidence Based Education) — Kate Jones Flashcards ebook (Evidence Based Education) — Kate Jones ResearchEd Guide to Cognitive Science (Kate wrote chapters on retrieval and spacing; Jonathan Firth on interleaving) Dunlosky (2013) - Strengthening the Student Toolbox Retrievalpractice.org (Pooja Agarwal's meta-analysis of classroom studies) Carousel Learning (Adam Boxer) TES (retrieval templates) You can connect with: Twitter/X: @KateJones_teach Email: katesofiajones@gmail.com Website: https://www.katejoneseducation.com/ You can connect with Brendan: Twitter/X: @learnwithmrlee Facebook: @learningwithmrlee Linkedin: @brendan-lee-kft Website: learnwithlee.net Support the Knowledge for Teachers Podcast: https://www.patreon.com/KnowledgeforTeachersPodcast enuine research from marketing spin, why fluency is about much more than speed, and the dangers of relying on “engagement” as a proxy for learning. Anna also highlights simple, practical strategies—like cover-copy-compare and spaced retrieval—that help students build the confidence they need to tackle more complex maths. If you've ever wondered how to cut through the noise and focus on what truly improves student outcomes, this conversation is packed with insights you can take straight back to your classroom. Resources mentioned: Wise Math (advocacy group) Archimedes Math School JUMP Math (Canadian maths program) Singapore Primary Math Program ResearchEd (conference, where Anna presented) Chalk and Talk (Anna Stokke's podcast) You can connect with Anna: Twitter/X: @rastokke Linkedin Website: https://www.annastokke.com/ You can connect with Brendan: Twitter/X: @learnwithmrlee Facebook: @learningwithmrlee Linkedin: @brendan-lee-kft Website: learnwithlee.net Support the Knowledge for Teachers Podcast: https://www.patreon.com/KnowledgeforTeachersPodcast About Dr. Anna Stokke is a Professor in the Department of Mathematics and Statistics at the University of Winnipeg. She is a recipient of a 3M National Teaching Fellowship, which is Canada's most prestigious award for teaching excellence and educational leadership at the post-secondary level. She is co-founder and President of the non-profit organization Archimedes Math Schools, which delivers after-school math classes for children. She hosts the popular math education podcast Chalk & Talk, where she discusses evidence-informed math teaching with leading education experts. 2025 Australian School Improvement Summit The 2025 Australian School Improvement Summit is coming to Sydney on Wednesday 29 October — a one-day event bringing together system leaders, researchers, principals, and expert practitioners to focus on what works in schools, and how to make it happen at scale. Hear from leading voices like Natalie Wexler (The Knowledge Gap), curriculum expert Dr Ben Jensen, and school leaders Lisa Holt (Rosebud Secondary College), Manisha Gazula (Marsden Road Public School), and Dr Greg Ashman (Ballarat Clarendon College). If you're a school leader or educator committed to improving outcomes for every student — and believe in doing fewer things, better — this is an event not to miss. Special offer for listeners: 20% off full-price tickets with code LearnWithLee. Check out the full program and register here: https://shorturl.at/Ku9v4
In today's episode, we had the pleasure of speaking with Stephen Liu, MD, about the use of tepotinib (Tepmetko) in patients with metastatic non–small cell lung cancer (NSCLC) harboring MET exon 14 skipping alterations. Dr Liu is an associate professor of medicine at Georgetown University, as well as the director of Thoracic Oncology and head of Developmental Therapeutics at the Georgetown Lombardi Comprehensive Cancer Center in Washington, DC. In our exclusive interview, Dr Liu discussed key efficacy and safety findings from the phase 2 VISION trial (NCT02864992) that led to the FDA approval of tepotinib for this indication; the comparable response rates seen between tissue and liquid biopsy results, as well as across NSCLC treatment lines; and the importance of early biomarker testing, including RNA sequencing, to identify actionable mutations and optimize treatment.
Aging is more than disease—it's the steady decline of function. In this episode of Longevity by Design, Dr. Gil Blander speaks with physicist-turned-biotech innovator Dr. Peter Fedichev about why resilience, not diseases, holds the key to longer lives.Peter explains how his background in theoretical physics shaped his approach to biology and aging. He outlines why startups, not large institutions, are now leading innovation in longevity science. Drawing from physics, he describes aging as a series of “jumps” between states, each leaving the body more fragile.The discussion moves from the limits of current drugs to the promise of new approaches. Peter argues that reducing fluctuations and increasing molecular fidelity could unlock far greater gains in healthspan and lifespan. Listeners gain a fresh lens on what drives aging, where the real breakthroughs may come from, and why the next frontier in longevity will require rethinking the problem altogether. Guest-at-a-Glance
Humans haven't been around for hundreds of thousands of years. We're all descended from Adam and Eve just a few thousand years ago. But what about the animals?
The rate at which mistakes pile up in the DNA we inherit from our mothers contradicts evolutionary ideas.
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