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Checkpoint Therapeutics ($CKPT) is an clinical stage oncology company that is focusing on developing treatments for solid tumors. Their lead candidate, Cosibelimab, is an anti-PD-L1 that has properties, which give it potentially more activity than checkpoint inhibitors that are currently on the market. In Q4-2021, they have an important pivotal readout, where we will get to see how effective Cosibelimab is in metastatic cutaneous squamous cell carcinoma. The company is also evaluating CK-101, a third generation EGFR inhibitor, which is also in phase 3. In this video, I interview James Oliviero, the CEO of Checkpoint Therapeutics, where discuss all this and more. Check out our sponsor: BiopharmIQ, which is the best place to get consolidated information about small-mid cap biotechs. Use my link here to let them know that I sent you: https://bit.ly/3iwVGbu Help out the show (or join the discord) by becoming a patron at: https://www.patreon.com/breakingbiotech Follow me on twitter @matthewlepoire Send me an email matthewlepoire@gmail.com www.breakingbiotech.com #breakingbiotech Disclaimer: All opinions expressed by Matt (or his guests) in this podcast are solely his (their) opinions. You should not treat any opinion expressed by Matt in this podcast as a specific inducement to make a particular investment or follow a particular strategy, but only as an expression of his opinion. Matt's opinions are based upon information he considers reliable, but Matt cannot warrant its completeness or accuracy, and it should not be relied upon as such. Matt is not under any obligation to update or correct any information provided in this podcast. Past performance is not indicative of future results. Matt does not guarantee any specific outcome or profit. You should be aware of the real risk of loss in following any strategy or investment discussed in this podcast. #biotech
This week Jason Fishman speaks with Sam Blan , Co-Founder and CMO of System 9. Sam walks us through how he was able to Test, Optimize, and Scale his businesses. Sam is a hands-on leader with a unique vision and a seasoned track record in corporate and international positions. A tech native executive and a problem solver experienced in startups of all kinds. Nuanced agility, tempered judgment, and entrepreneurial talents are some of his hallmarks. Skilled at making quick decisions and the unwavering determination of follow through. He started his career in the film space identifying new business/acquisitions in entertainment/film/content for several years including working for a production company located at Universal Studios. Much of his work has been in an international capacity: sourcing/acquiring creative and innovative properties in tech and entertainment, working on contracts/negotiations and in physical production. His entrepreneurial spirit has led him to work in several other fields from 2015-2018 including: tech, hardware, nonprofit, fundraising and fashion. He’s worked on crowdfunding campaigns and projects in the rewards, equity and non-profit space. He entered the embryonic blockchain / crypto industry in 2016. First as an investor of innovative projects, growing holdings across several protocols and tokens. In Q4 of 2017, he co-founded System 9, a digital software and market making firm building trading algorithms for FinTech, blockchain and the overall cryptocurrency marketplace. Linkedin: https://www.linkedin.com/in/samblan/ Website:https://system9.io For more episodes and information, visit us at https://www.digitalnicheagency.com/media Apple Podcasts: https://podcasts.apple.com/us/podcast/test-optimize-scale/id1508379681 Spotify: https://open.spotify.com/show/4zS5V79xPwTsrYiyibaS2b Stitcher: https://www.stitcher.com/s?fid=524781&refid=stpr Follow Digital Niche Agency on Socials for Up To Date Marketing Expertise and Insights Facebook: https://www.facebook.com/digitalnicheagency/ Linkedin: https://www.linkedin.com/company/digital-niche-agency Instagram: DNA - Digital Niche Agency (@digitalnicheagency) • Instagram photos and videos. Twitter: https://twitter.com/DNAgency_CA YouTube: https://www.youtube.com/channel/UCDlzUtbB5RMpzRmDu9wtfRQ/
In Q4 2020, Amazon's Fire TV was king of all connected TV device sales. How does archrival Roku fare? And we review three ways a CTV platform influences what we watch and why we may not even notice.
Gunsynd Plc (AIM: GUN, AQSE: GUN) is pleased to announce that it has received a shareholder update from its investee company Low6 Limited (“Low6”), a UK based, influencer led, B2B pool betting platform for franchises around the world. Low6 offers a white-label pool betting platform for professional sports franchises. In Q4 2020, Low6 closed a pre-IPO round, organised by Canaccord Genuity. As announced on 14 December 2020, Gunsynd subscribed for 6,667 ordinary shares at a price of £30 per share for a total consideration of 200,010 Peter Ruse, Gunsynd PLC Director, commented: “Gunsynd is very pleased to provide this update to our shareholders. The Low6 business has demonstrated strong monthly active user growth since our investment in December 2020, launching its pool betting software across a number of platforms within popular sporting codes. We believe the cost per acquisition of users to the Low6 platform is considerably lower than the industry average and proves the disruptive nature of this business. Furthermore, we are delighted to learn that the business has attracted what it believes to be a high calibre gaming investor to its shareholder register and advisory board.”https://www.share-talk.com/peter-ruse-director-gunsynd-plc-gun-l-low6-update-interview/
In Q4 2018, Oliver Weingarten co-founded a grassroots, fan-focused esports org, LDN UTD, to provide opportunity and accessibility for gamers to take the path to pro, whilst aligning with societal benefits (fitness, nutrition, life skills) and social purpose. Gamers upload their best content to the platform and fans vote their favorite. The gamers are invited to “try-out” against each other for places (and a contract) in LDN UTD’s team. To date they have created Fortnite, Apex, and FIFA teams, hosting events at traditional gaming bars as well as in Lewisham Shopping Centre (#GrimeAgainstKnives). Oliver Weingarten is also a commercially astute leader and experienced Board member with a strong passion for sports. His original career in law at the Premier League transitioned into one with a focus on broader sports business including the commercial and broadcasting landscape. This is demonstrated by his cumulative ten years of working at the Premier League (in a General Counsel role) and thereafter Formula One Teams' Association (as Secretary General) operating in challenging environments, before getting involved in Formula E, technology and esports. Get in touch with Oliver Weingarten here. Visit https://www.ldnutd.gg/
Reviews This Week: Thermaltake Level 20 RGB Titanium Gaming Keyboard Review (https://thinkcomputers.org/thermaltake-level-20-rgb-titanium-gaming-keyboard-review/) Lamptron SM436 Sync Edition Fan & RGB Controller Review (https://thinkcomputers.org/lamptron-sm436-sync-edition-fan-rgb-controller-review/) Other Stuff This Week: Case Mod Friday: Project JARVIS (https://thinkcomputers.org/case-mod-friday-project-jarvis/) Win a Fractal Design Define 7 Case (https://thinkcomputers.org/win-a-fractal-design-define-7-case/) News This Week: AMD GPU Shipments up 22.6% In Q4’19 (https://thinkcomputers.org/amd-gpu-shipments-up-22-6-in-q419/) NVIDIA Cards With 108 and 118 Compute Units Spotted, Possibly Ampere? (https://thinkcomputers.org/nvidia-cards-with-108-and-118-compute-units-spotted-possibly-ampere/) NVIDIA GPU Technology Conference Shifted to Online Event over Coronavirus Concerns (https://thinkcomputers.org/nvidia-gpu-technology-conference-shifted-to-online-event-over-coronavirus-concerns/) A Company is Selling a Gaming Bed (https://thinkcomputers.org/a-company-is-selling-a-gaming-bed/) Mountain Unveils the Everest Modular Gaming Keyboard (https://thinkcomputers.org/mountain-unveils-the-everest-modular-gaming-keyboard/) EKWB Presents the EK-Quantum Magnitude CPU Water Block (https://thinkcomputers.org/ekwb-presents-the-ek-quantum-magnitude-cpu-water-block/) FSP Announces the New T-WINGS 2-in-1 High-end PC Chassis (https://thinkcomputers.org/fsp-announces-the-new-t-wings-2-in-1-high-end-pc-chassis/) Herman Miller & Logitech G Join Forces to Create High-Performance Furniture Solutions for Gamers (https://thinkcomputers.org/herman-miller-logitech-g-join-forces-to-create-high-performance-furniture-solutions-for-gamers/) Coming Next Week: ASRock X570 Phantom Gaming-ITX/TB3 Motherboard (http://asrock.com/mb/AMD/X570%20Phantom%20Gaming-ITXTB3/index.asp) SilverStone SETA A1 Case (https://www.silverstonetek.com/product.php?pid=894&area=en) Home Gadget Geeks - 435 (https://theaverageguy.tv/live/) - Thursday, March 12th, 8:00 PM CST
In this interview Jamie Strauss, provides an overview of Digbee, which is a new data and research platform for the mining industry. Digbee matches appropriate experts with mining feasibility studies to create objective, original and concise reports. In May 2019 it was launched as a freely available database of over 3,000 economic studies, displayed on an attractive map, with over 60 data points for each project. In Q4 2019, Digbee will go-live with its Digbee Research Reports. These provide on-demand and completely independent analysis of published feasibility studies. Digbee’s unique, expert network of mining professionals will author these reports to the very highest standards. In addition to founding Digbee, Jamie Strauss is the founding partner of Strauss Partners Ltd. He has worked as a stockbroker in the City of London for over 30 years specializing for 20 years within the resources industry. He was previously Managing Director of UK Equity product at BMO Capital Markets, prior to which he was a director of Hargreave Hale Ltd where he founded, developed and then sold a mining institutional sales and research department. Jamie started his career in 1986 at Strauss Turnbull (subsequently bought by Société Générale). Jamie has experience in sales, research, transaction structuring, IPO’s and syndication. He is a non-executive director of several mining companies. https://thedigbee.com/ Sign up for our free newsletter and receive interview transcripts, stock profiles and investment ideas: http://eepurl.com/cHxJ39 Mining Stock Education LLC has not received compensation from Digbee to conduct this interview. The content found on MiningStockEducation.com is for informational purposes only and is not to be considered personal legal or investment advice or a recommendation to buy or sell securities or any other product. It is based on opinions, SEC filings, current events, press releases and interviews but is not infallible. It may contain errors and MiningStockEducation.com offers no inferred or explicit warranty as to the accuracy of the information presented. If personal advice is needed, consult a qualified legal, tax or investment professional. Do not base any investment decision on the information contained on MiningStockEducation.com or our videos. We may hold equity positions in and/or be compensated by some of the companies featured on this site and therefore are biased and hold an obvious conflict of interest. MiningStockEducation.com may provide website addresses or links to websites and we disclaim any responsibility for the content of any such other websites. The information you find on MiningStockEducation.com is to be used at your own risk. By reading MiningStockEducation.com, you agree to hold MiningStockEducation.com, its owner, associates, sponsors, affiliates, and partners harmless and to completely release them from any and all liabilities due to any and all losses, damages, or injuries (financial or otherwise) that may be incurred.
Episode brought to you by Amazon (http://www.thinkcomputers.org/amazon). Reviews This Week: Gigabyte GeForce GTX 1660 Ti Gaming OC 6G Graphics Card Review (https://thinkcomputers.org/gigabyte-geforce-gtx-1660-ti-gaming-oc-6g-graphics-card-review/) Mushkin Redline DDR4-3200 16GB Memory Kit Review (https://thinkcomputers.org/mushkin-redline-ddr4-3200-16gb-memory-kit-review/) Other Stuff This Week: Beginner’s Guide To Twitch Streaming – Part 2 (https://thinkcomputers.org/beginners-guide-to-twitch-streaming-part-2/) Case Mod Friday: Copper II (https://thinkcomputers.org/case-mod-friday-copper-ii/) News This Week: MSI GTX 1660 (non-Ti) Cards Spotted, GDDR5 Memory and 1408 CUDA Cores (https://thinkcomputers.org/msi-gtx-1660-non-ti-cards-spotted-gddr5-memory-and-1408-cuda-cores/) EVGA and Gigabyte GeForce GTX 1660 Cards Spotted (https://thinkcomputers.org/evga-and-gigabyte-geforce-gtx-1660-cards-spotted/) NVIDIA Discrete GPU Market Share Grew To 81.2% In Q4 2018 (https://thinkcomputers.org/nvidia-discrete-gpu-market-share-grew-to-81-2-in-q4-2018/) Are the Long Awaited GPU Price Drops Finally Coming? (https://thinkcomputers.org/are-the-long-awaited-gpu-price-drops-finally-coming/) Intel Teasing New Control Panel For Discrete GPUs (https://thinkcomputers.org/intel-teasing-new-control-panel-for-discrete-gpus/) Intel CPU Shortages To Get Worse Through Q2-2019 (https://thinkcomputers.org/intel-cpu-shortages-to-get-worse-through-q2-2019/) AMD 3rd Gen Ryzen Threadripper Confirmed For Late 2019 Launch (https://thinkcomputers.org/amd-3rd-gen-ryzen-threadripper-confirmed-for-late-2019-launch/) TrendForce: Recent DRAM Pricing Decline Biggest Since 2011, Nearly 30% Decrease (https://thinkcomputers.org/trendforce-recent-dram-pricing-decline-biggest-since-2011-nearly-30-decrease/) CORSAIR Launches Crystal Series 680X RGB and Carbide Series 678C Cases (https://thinkcomputers.org/corsair-launches-crystal-series-680x-rgb-and-carbide-series-678c-cases/) Battlefield V Firestorm Battle Royal Mode Detailed In Leaked Video (https://thinkcomputers.org/battlefield-v-firestorm-battle-royal-mode-detailed-in-leaked-video/) Apex Legends Battle Pass Rumored To Launch March 12th (https://thinkcomputers.org/apex-legends-battle-pass-rumored-to-launch-march-12th/) Respawn Has Banned 355,000 Cheaters From Apex Legends (https://thinkcomputers.org/respawn-has-banned-355000-cheaters-from-apex-legends/) Coming Next Week: New Graphics card AVA Direct AMD Raven Ridge Gaming System Cooler Master SK630 Gaming Keyboard (http://www.coolermaster.com/peripheral/keyboards/sk630/)
52: Carly Mantione - Loopio’s top AE - Getting to Value Quickly Extensive show notes with links to items mentioned in the show available at: https://top1.fm/52 Carly Mantione is the #1 Senior Account Executive at Loopio. Carly intentionally got into sales after watching her dad support her family on an entirely commission-based sales role. Both of her siblings and many of her relatives are also in sales. After university she went into a more transactional sales role at company called Rogers, selling to small businesses. She was successful there and fell in love with selling but realized she wanted to be more in a solution sales role with enterprise companies. Then she went to an SDR role at Influitive before coming to Loopio as a Senior SDR and helped build out the outbound process. Then she became an AE, then a Senior AE and that led her to where she is today. With the intention of achieving 150% of her annual quota in 2017, Carly ended up exceeding her quota every quarter. In Q4, she beat her quarterly number by over 200 percent and hit 170 percent quota attainment for the year.
The Top Entrepreneurs in Money, Marketing, Business and Life
Shan-Lyn Ma. She’s the CEO and co-founder of Zola. Launched in October 2013, Zola is an online wedding registry for millennials. In just three years, it has become the fastest growing wedding registry in the country, seeing 10x revenue growth year-over-year and 3x growth in 2017. Over seven million guests have attended a Zola wedding and 350 million in gifts have been added by Zola couples. Famous Five: Favorite Book? – How to Create Products Customers Love What CEO do you follow? – Sheryl Sandberg Favorite online tool? — Headspace How many hours of sleep do you get?— 8 If you could let your 20-year old self, know one thing, what would it be? – “That stressing out about things do not make them better” Time Stamped Show Notes: 01:47 – Nathan introduces Shan-Lyn to the show 02:32 – In Q4 of 2016, Zola reached $120M in GMV runway 03:30 – GMV is reflective of the number of wedding gifts that are given to couples when using Zola as a wedding registry 03:56 – Zola is an ecommerce business, it’s a typical retailer 04:40 – Most of the items offered in Zola are what the couples want as wedding gifts 04:50 – Zola has added Airbnb as this was requested by couples 05:20 – Zola takes a percentage from an Airbnb gift card purchased on Zola 06:14 – Zola goes after the brands that are usually requested by couples and some brands have reached out to Zola for their products to be on Zola’s website 06:54 – Since 2013, 300K couples have registered with Zola 07:25 – The number of new couples signed-up in 2016 08:10 – Over time, more and more couples are using Zola as their ONLY wedding registry 09:40 – More guests will buy from Zola if the couples are using Zola exclusively as their wedding registry 10:02 – Zola incentivizes couples by adding the gifts that they want 10:24 – There’s an additional feature where couples can bring any product to Zola 11:12 – First year revenue 11:38 – Zola had a seed round of funding of $500K in a convertible note 12:17 – Zola has raised additional capital with a total of $40M in VC funding 12:36 – Zola has passed through the typical startup life-cycle 14:14 – Paid ads spend is more than $100K 14:41 – The hot KPI that investors are looking for is the LTV:CAC ratio 15:51 – CAC depends on the channel and historical data of the channel’s performance 17:42 – “We are not trying to create more lifetime value” 18:30 – The challenge for Zola is getting newly engaged couples to find out about their services and sign-up for them 19:49 – Zola currently has over 50K products 20:22 – Zola just launched their new product, Zola Weddings, a free website for couples to manage their whole wedding 23:25 – The Famous Five Key Points: Listen to your customers desires and needs and respond accordingly. LTV:CAC ratio is what investors are usually looking for in a company. Create more products that could be an extension of your existing products—this will encourage your clients to use your products more. Resources Mentioned: Simplero – The easiest way to launch your own membership course like the big influencers do but at 1/10th the cost. The Top Inbox – The site Nathan uses to schedule emails to be sent later, set reminders in inbox, track opens, and follow-up with email sequences GetLatka - Database of all B2B SaaS companies who have been on my show including their revenue, CAC, churn, ARPU and more Klipfolio – Track your business performance across all departments for FREE Hotjar – Nathan uses Hotjar to track what you’re doing on this site. He gets a video of each user visit like where they clicked and scrolled to make the site a better experience Acuity Scheduling – Nathan uses Acuity to schedule his podcast interviews and appointments Host Gator– The site Nathan uses to buy his domain names and hosting for the cheapest price possible Audible– Nathan uses Audible when he’s driving from Austin to San Antonio (1.5-hour drive) to listen to audio books Show Notes provided by Mallard Creatives
It’s no secret that online retail is slowly killing offline retail. In Q4 2016, 8.3% of total US retail sales were online (about $103 billion), up from 5.1% just five years ago (about $53 billion). Offline sales were 91.7% of...
In Q3, NLMK Group sales remained stable at 3.8 million tonnes (+0.2% q-o-q). NLMK grew its finished product sales in the domestic market to 1.283 million tonnes (+5% q-o-q), capitalising on demand from its key consumers, i.e. Russian construction and machine-building sectors. The share of domestic sales increased to 34% (+2 p.p.). As demand for flat steel in the export markets weakened, NLMK grew its slabs sales as these enjoyed stable demand. In 9M 2012, NLMK Group produced 11.2 million tonnes of steel, up 24% y-o-y. Around 95% of all steel was produced domestically. Outlook In Q4, the Groups steel production is expected to remain unchanged at 3.8 million tonnes. NLMK Group confirms its previously announced steel production forecast for 12M 2012 at 15 million tonnes.