Podcasts about cac

Vitamin K2 (MK-7) and Coronary Artery Calcification: Insights from a 2-Year Trial: Nutritionist Leyla Muedin discusses a two-year randomized clinical trial in JAMA Cardiology from Maastricht University Medical Center reporting that daily vitamin K2 (menaquinone-7, MK-7) at 360 mcg slowed progression of coronary artery calcification (CAC) in 180 patients with confirmed atherosclerotic cardiovascular disease and baseline CAC 50–400 Agatston units. Compared with placebo, consistent MK-7 use was associated with 29% lower CAC progression and 42% less arterial calcium mass progression, though CAC still increased in both groups; stenosis increases were numerically lower with MK-7 but not statistically significant. Leyla notes many participants were on statins and were smokers, highlighting that statins can raise CAC by stabilizing soft plaque via calcification. The trial suggests MK-7 may slow calcification in newer plaques, may improve arterial elasticity via matrix GLA protein activation, is inexpensive and safe, but clinical event reduction remains unproven; Leyla suggests considering MK-7 (possibly 360 mcg) with vitamin D, magnesium, and dietary measures.

Brian O'Connor spent three years building a 40,000-person Twitter following, launched product after product into that audience, and made almost nothing. The turning point came when he stopped looking for clever ideas and started running a boring business where product market fit already exists. He wrote down everyone he knew, sent texts, and sold $20K of recruiting services off a single Google Doc in two weeks. Today he runs TalentHQ, a recruiting agency placing Latin American project managers into US businesses — built nomadically with a co-founder, now operating with a team of two plus AI. In this conversation: why reach and revenue have almost nothing to do with each other, how he turned a podcast into his primary acquisition channel, and what it actually looks like to build a service business from scratch in 2026. Guest: Brian O'Connor, Founder of Talent HQ Sponsor: wayfront.com/tmba Thanks to this week's sponsor Wayfront — the AI-ready operating system for productized agencies. One client portal. One team dashboard. All your data, AI-accessible. TMBA listeners get an extra free month on top of the trial at wayfront.com/tmba. Links: Business Resources Upcoming DC Events

The PIMCON Lineup Keeps Growing! Get a preview of the insights, strategies, and stories you'll see this year at the PIMCON stage. Customer acquisition costs keep rising, private equity keeps entering the market, and direct-to-consumer advertising gets more expensive every year. The firms finding new growth opportunities are building systems their competitors can't easily replicate. Anthony Lopez and Ilana Reeser have helped transform Your Insurance Attorney into a 300-person firm with 50 attorneys operating across multiple states. Anthony serves as CEO, leading the firm's technology and operational strategy, while Ilana has built a nationwide referral ecosystem that now generates hundreds of cases each month. In this episode, Anthony and Ilana share how they created a scalable growth engine by combining a structured B2B referral network with proprietary AI technology. They discuss the metrics they use to evaluate profitability, the systems required to manage high-volume referrals, and why strong partner relationships have become a competitive advantage in today's legal market. They also reveal how their custom AI platform is reshaping intake, case management, and operational efficiency across the firm. On this episode, you'll learn: Why B2B referral networks create a more scalable growth channel than relying exclusively on direct-to-consumer marketing. How nationwide referral partnerships generate hundreds of cases per month while strengthening reciprocal relationships. The kept CAC metric that reveals whether a marketing channel is actually profitable. How custom AI technology automates intake, client communication, and case management workflows. Unlock the exact strategies to scale your firm by heading over to pimcon.org and securing your tickets for PIMCON 2026. Like what you hear? Hit Subscribe! We do this every week.  For more resources on how to dominate your market, visit us at Rankings.io. Subscribe to our newsletter and get the freshest news every Monday: newsletter.rankings.io Get Social! Personal Injury Mastermind w/ Chris Dreyer powered by Rankings.io is on Instagram | YouTube | TikTok

AI ARR is easy to announce. Proving it is where most SaaS finance teams are about to get exposed. In episode #379, Ben Murray tackles the new bar for AI financial transparency and what it means for your next budget season. The public markets have already moved the goalposts. Launching AI was the 2024 story. Reporting AI ARR was the 2025 story. Now investors and boards want to see AI margins, customer outcomes, and proof that AI revenue is actually dropping to the bottom line. That same pressure is heading straight for private SaaS, and your board will bring it to budget season whether you are ready or not. Understand why AI ARR by itself no longer satisfies boards or investors, and what they now demand to see in the numbers. Separate pure AI revenue, AI-influenced revenue, and AI upsell so your reporting survives scrutiny, using clean SKUs, product IDs, and chart of accounts. Know which AI costs belong in COGS, including inference, infrastructure, and observability, so you can show your real AI margins. Walk into budget season ready for the board questions on AI revenue, AI cost, and margin by revenue stream. Instrument heavy, medium, and light AI users so you can defend margins and LTV to CAC as usage scales. Listen now and build the AI transparency your board will expect before budget season starts. Resources Mentioned Ben's blog posts on capturing AI costs in COGS: inference, infrastructure, and observability: https://www.thesaascfo.com/what-should-be-included-in-ai-cogs/ Ben's training on AI metrics: https://www.thesaasacademy.com/ai-finance-metrics-saas

Send us Fan MailWe talk with Mike Ferreira about the moment a serious neck injury forced him to step out of his gym and finally build a business that works without him. We break down the skills, numbers, and leadership habits that turn a capped fitness business into a scalable machine while keeping family and real life in focus.• building a “jail cell” by wearing every hat• the emotional cost of missing family moments• why desperation creates bad business decisions• learning to ask better questions under pressure• finding mentorship that simplifies gym business fundamentals• using theory of constraints to diagnose bottlenecks• tracking CAC and LTV like you track macros• becoming a leader worth following through extreme ownership• protecting relationships, health, and meaning with the five pillarsYou can find us on the web at gymlaunch.com, and we love to hop on a call and have an honest conversation about whether we can help you or notHow To Reach Mike Ferreira:Instagram: https://www.instagram.com/realmikef/How to Learn More about Gym Launch:https://www.gymlaunch.com/ To Reach Jordan:Email: Jordan@Edwards.Consulting Youtube:https://www.youtube.com/channel/UC9ejFXH1_BjdnxG4J8u93ZwFacebook: https://www.facebook.com/jordan.edwards.7503Instagram: https://www.instagram.com/jordanfedwards/Linkedin: https://www.linkedin.com/in/jordanedwards5/Hope you find value in this. If so please provide a 5-star and drop a review.Complimentary Edwards Consulting Session: https://calendly.com/jordan-edwardsconsulting/30min 

You can close $800 million deals, fly first class, and still be going broke on the inside. In this episode of The Fulfillionaire, Cruz Gamboa, Founder and Managing Partner of Ascend Growth Ventures, shares the full unfiltered story and the clarity, cash flow framework, and mindset shifts that finally set him free. Cruz breaks down the three metrics that actually tell you whether your business is healthy: profit margin over gross revenue, cash burn, and the LTV-to-CAC ratio.  But tactics without clarity are just expensive noise. His BHAG framework exposes the real problem most entrepreneurs avoid: they chase a number without knowing why it matters, which means they have no filter for what to pursue, what to cut, or when enough is actually enough. When clarity replaces ambition as your compass, decisions get easier, the right people find you, and the work starts to feel like a mission instead of a grind.   The breakthrough was always on the other side of the burnout. When you are ready to stop building income and start building a life, visit fulfillionaire.com. Don't miss the full episode of Why High Achievers Burn Out Before They Break Through with Cruz Gamboa. Cruz Gamboa is the Founder and Managing Partner of Ascend Growth Ventures, bringing over 25 years of experience as a corporate CFO navigating capital markets, structured finance, and project finance across Latin America. He has closed deals as large as $800 million and built financial models that moved real money at the highest levels of business and government. But behind the credentials was a man who stayed nearly eight years past the moment he knew it was time to leave. Cruz now channels that hard-won experience into helping high achievers recognize the burnout beneath the success before it costs them everything. Website: https://cruzgamboa.com/  Instagram: https://www.instagram.com/cruzgamboa.ascend/  LinkedIn: https://www.linkedin.com/in/cruzgamboa/  YouTube: https://www.youtube.com/@ascendgrowthventures  Ascend Growth Ventures Website: https://ascendgrowthventures.com/  Facebook: https://www.facebook.com/ascendgrowthventures/  LinkedIn: https://www.linkedin.com/company/ascendgrowthventures/  JP Newman is the founder of Fulfillionaire and CEO of Thrive FP, known for helping high-achievers align financial success with deeper human connection and purpose. With over $2 billion in real estate transactions and hundreds of investors coached, he brings a powerful blend of strategy, psychology, and emotional intelligence to the world of investing and negotiation. JP teaches that the best deals are built by understanding people, energy, and intention. Through his Fulfillionaire™ movement, he helps leaders stop operating from fear and start making decisions rooted in clarity and alignment. His approach redefines negotiation as a human-centered skill that turns insight into influence and lasting success. IG: https://www.instagram.com/jpnewman_/  LI: https://www.linkedin.com/in/jp-newman-45a1ba/     

O que é GEO e por que sua marca precisa aparecer nas respostas do ChatGPT, Gemini e Perplexity antes dos seus concorrentes? O SEO não morreu, mas o jogo mudou. Com a ascensão das IAs generativas, não basta mais ranquear no Google: é preciso ser a resposta que os modelos de linguagem escolhem quando alguém pergunta sobre o seu mercado. Neste episódio do Papo Social Media, Rafael Kiso e Marcio Silva recebem Diego Ivo, CEO e fundador da Conversion, maior agência de SEO do Brasil, para uma aula completa sobre GEO (Generative Engine Optimization) e o impacto da busca generativa no marketing digital. A conversa explora como funciona a lógica dos tokens nas LLMs, porque o LinkedIn é hoje a principal fonte citada pelas IAs em contexto B2B, como o framework EEAT do Google se aplica diretamente ao posicionamento nas ferramentas de IA, e quais estratégias práticas qualquer marca pode adotar agora para treinar os modelos de linguagem a seu favor. Um episódio essencial para profissionais de marketing, agências e gestores que querem entender o novo cenário da busca e garantir visibilidade na era da inteligência artificial. 00:00:08 Introdução e apresentação de Diego Ivo 00:01:40 O que é GEO, AIO e os diferentes termos para a otimização em IAs generativas 00:05:00 A fragmentação das buscas: Google, YouTube, TikTok, marketplaces e LLMs 00:07:55 Como funcionam os tokens e por que sua marca precisa ser o próximo token mais provável 00:09:24 LLMs consultam o Google em tempo real: por que o SEO está mais vivo do que nunca 00:10:19 GEO vs SEO: o guarda-chuva da busca e a ressignificação do que é otimização 00:13:00 A migração do clique para a resposta: o fim do modelo baseado em last click 00:16:57 Autoatribuição: a métrica mais poderosa para entender de onde vêm seus clientes 00:20:23 Zero click search: buscas sem clique crescem de 56% para 69% no Google 00:21:20 ChatGPT, Claude e o novo cenário competitivo das IAs generativas 00:25:48 Framework EEAT: Experience, Expertise, Authority e Trustworthiness aplicados ao GEO 00:31:26 Por que o LinkedIn é a fonte número 1 das LLMs em contexto B2B 00:33:41 Artigos e newsletters do LinkedIn vs posts do feed: o que as IAs realmente consomem 00:34:20 TikTok e indexação por áudio: o próximo passo das LLMs para vídeos 00:36:10 Branding semântico: como treinar os modelos de linguagem com os atributos da sua marca 00:41:10 Fontes externas que mais influenciam as LLMs 00:44:39 As principais digas técnicas para aparecer nas respostas de buscas 00:54:02 Thought leadership e founder-led growth: por que o executivo precisa criar conteúdo 00:58:31 Conteúdo factual e recência: como funciona para as LLMs 01:02:50 As principais métricas do GEO: autoatribuição, share of search, CAC e LTV 01:09:10 O futuro: de assistentes para agentes que operam processos inteiros 01:10:32 Inteligência vs julgamento: o que pode ser automatizado e o que ainda é humano 01:14:05 Harness proprietário: como criar arquiteturas de agentes que geram diferenciação competitiva 01:23:09 Encerramento  Acompanhe   Diego Ivo: LinkedIn - https://www.linkedin.com/in/diegoivo/  | Instagram - https://www.instagram.com/diegoivo  Conversion: LinkedIn - https://www.linkedin.com/company/agenciaconversion/ |   Instagram - https://www.instagram.com/agenciaconversion/  Rafael Kiso: LinkedIn - https://www.linkedin.com/in/rafaelkiso/ | Instagram -  https://www.instagram.com/rafaelkiso/  Potencialize sua gestão de mídias sociais com a plataforma mais usada por agências e profissionais no Brasil! Teste grátis a mLabs agora mesmo: https://mla.bs/8f82d839

Ready to simplify your med spa operations and grow smarter? Visit https://www.glossgenius.com/medspasuccessstrategies and use code STRATEGIES for 50% off your first 2 months of Gold or Platinum.Why do so many med spa owners feel like their marketing is working, but still struggle with real, sustainable growth? And why do some practices stay stuck with inconsistent results even while actively investing in ads?In this episode, Ricky and Lauren break down the most common marketing mistakes med spa owners make when evaluating their strategy and performance. These mistakes often lead to misread data, unrealistic expectations, and frustration with otherwise effective campaigns.They also break down the real trade-offs behind every marketing decision, including volume vs profitability, short-term vs long-term thinking, and why strategy must align with your stage of growth and operational capacity.This episode will help you better understand what actually drives marketing success versus what only creates short-term noise.You will learn:✅ Why short-term “test” thinking limits long-term growth✅ The trade-offs between volume, profitability, and patient quality✅ Why over-optimizing for high-ticket patients or high margins reduces compounding growth✅ Why brand, reputation, and consistency now outweigh promotions alone✅ Why initial visit revenue and lifetime value can both mislead if used in isolation✅ Why butts-in-seats and premium-only strategies both break at scale✅ Why attribution misses much of what actually drives patient acquisition✅ Why marketing cannot fix broken intake, consult, or rebooking systems✅ How pre-booking and retention systems impact long-term revenue✅ Why knowing your numbers (CAC, retention, AOV) is non-negotiable✅ Why personal brand and provider visibility drive conversion and trust✅ Why channel mix (Meta vs Google vs others) directly impacts acquisition cost✅ Why consistency beats stop-start marketing every time✅ Why anecdotes should never override full data sets when evaluating performanceIf you are a med spa owner trying to scale more predictably, improve lead quality, increase retention, and make better marketing decisions, this episode will help you understand what actually drives growth and what is just surface-level performance.If you're ready to implement more efficient & effective marketing strategies for your practice, book your FREE strategy session & marketing plan: https://go.medspamagicmarketing.com/scheduleFollow us on social media: https://www.instagram.com/medspamagicmarketing/https://www.linkedin.com/company/med-spa-magic-marketing/https://www.facebook.com/MedSpaMagicMarketing/https://www.tiktok.com/@medspamagicmarketing

Nos visita desde España, Álvaro Ovejas escofundador y CEO de Lead Motiv, consultora digital especializada en ayudar aempresas de servicios a construir sistemas de crecimiento más sólidos, mediblesy orientados a negocio. Desde hace más de 14 años trabaja en la intersecciónentre marketing, ventas y tecnología, acompañando a compañías B2B y B2C en eldiseño de estrategias de captación, conversión y gestión de leads, con unavisión muy enfocada en resultados: generar más oportunidades cualificadas,mejorar la eficiencia comercial y tomar decisiones basadas en datos.Desde Lead Motiv, Álvaro impulsa unenfoque de trabajo que va más allá de la ejecución de canales aislados. Suvisión parte de entender al detalle las bases estratégicas: modelo de negocio,ICP, Propuesta de valor y objetivos, para definir sistemas de adquisición,automatización y conversión que conecten marketing y ventas. Como CEO yconsultor estratégico, combina experiencia práctica, visión de crecimiento ycercanía con los equipos directivos para ayudar a las empresas a vender más ymejor, con mayor control sobre métricas clave como SQL, CAC, LTV y retorno dela inversión. Links :De la empresa (Lead Motiv)https://leadmotiv.com/https://www.linkedin.com/company/leadmotiv/https://www.instagram.com/leadmotiv/ De los socioshttps://www.linkedin.com/in/alvaro-ovejas/https://www.linkedin.com/in/josemariafrancomartinez/

Want to scale your health practice and get your life back? Work with me 1-on-1 in our private advisory and mastermind - https://go.healthpreneurtraining.com/hp-mastery?el=yt-june21Most health practice owners eventually hit the same wall. The business is growing, revenue is up, and patients or clients are getting results, but too much still depends on you. The next level isn't about doing more. It's about building something bigger than yourself. A business that scales without relying on you for everything.That's why we created Healthpreneur Mastery.Mastery is the private advisory board and mastermind for leading health professionals doing at least $500,000 per year who want to build a business that creates greater profit, freedom, and impact.This isn't for beginners.It's for practitioners, practice owners, and health entrepreneurs who know they're capable of building something much bigger and don't want to figure it all out alone.Learn more about Healthpreneur Mastery here: https://go.healthpreneurtraining.com/hp-mastery?el=yt-june21Your health practice is generating millions but your margins keep shrinking, your cost to acquire a patient keeps climbing, and ads do not work the way they used to. There is a specific reason this is happening, and it is not the one most practitioners think.In this episode, I walk through a real $4 million practice case study where revenue is strong but cost per consult, cost to acquire a client, and shrinking ad efficiency are quietly eating into profit. I break down exactly how to diagnose where the leaks are in your funnel, why simply increasing ad spend makes the problem worse, and what creative mix and campaign structure actually mean for your Meta ads performance. 

La última sesión de la semana deja una fotografía de mercado claramente favorable para la renta variable. En Europa, aunque algunos índices como el DAX o el CAC 40 muestran un peor comportamiento, el protagonismo cae sobre el IBEX 35, el EuroStoxx 50 y, especialmente, el sector bancario europeo, que mantienen una tendencia claramente alcista. El selectivo español cotiza en torno a los 19.364 puntos, consolidando las ganancias acumuladas en las últimas semanas. Al otro lado del Atlántico, el escenario continúa siendo positivo. Los principales índices estadounidenses siguen instalados en tendencia alcista y muy cerca de máximos históricos. Destaca especialmente el índice de semiconductores de Filadelfia, que continúa liderando las subidas gracias al impulso de todo el ecosistema vinculado a la inteligencia artificial y la tecnología. Sin embargo, el buen tono no se limita al sector tecnológico, ya que el S&P 500 y el Nasdaq apenas se han alejado de sus máximos pese a las recientes tomas de beneficios. Según Roberto Moro, el mercado ha recuperado prácticamente el mismo escenario que existía antes de que las tensiones geopolíticas en Oriente Medio alteraran temporalmente el sentimiento inversor. Ni los conflictos internacionales ni la volatilidad asociada han sido capaces de deteriorar una tendencia de fondo que sigue siendo constructiva tanto en Europa como en Estados Unidos. En este contexto, Moro plantea una estrategia de pares destinada a reducir la exposición a los movimientos generales del mercado. La propuesta consiste en comprar un ETF vinculado al sector financiero europeo y, simultáneamente, abrir una posición equivalente mediante un ETF inverso sobre el sector automovilístico europeo. Basado en la fortaleza relativa que están mostrando los bancos frente a unas compañías automovilísticas que continúan atravesando un momento complicado. Valores como BMW, Mercedes-Benz, Renault o Stellantis siguen mostrando debilidad técnica y un comportamiento claramente inferior al del sector financiero. La estrategia busca aprovechar que esta divergencia continúe durante las próximas semanas, independientemente de la dirección general que adopten las bolsas, reduciendo parte de la volatilidad a una posición tradicional de mercado.

Free course: Improve your metabolic healthGet our free email course on how glucose, nutrition, exercise, sleep, and measurement can help you build habits that support better energy and long-term health: ⁠⁠⁠https://levels.link/wnl⁠High cholesterol. Elevated ApoB. A positive CAC score. Now what?Most people quickly find themselves trapped between two extremes: simplistic advice to “cut saturated fat” and online influencers insisting cholesterol doesn't matter at all.In this episode of A Whole New Level, Mike Haney sits down with clinical research scientist Dr. Kevin Maki to cut through the confusion.Drawing on more than 35 years of cardiovascular research, Maki explains why heart disease risk is about much more than LDL cholesterol alone. He breaks down the roles of inflammation, blood sugar, family history, kidney function, and lipoproteins, while also making a clear case for something many people resist: LDL and ApoB still matter. A lot.The evidence increasingly suggests that when it comes to atherosclerosis, lower for longer is better. That has important implications for diet, statins, and how early we should intervene.Mike and Dr. Maki also tackle saturated fat, seed oils, red meat, industry-funded research, and how to separate evidence from online nutrition debates.

On this episode, Christian Chauvet, Partner at Lee Equity, shares how vertical focus creates a structural advantage in healthcare and financial services investing—and what it takes to build and scale founder-led businesses in highly regulated, service-intensive industries.Hear how a people-process-systems playbook drives organic growth across healthcare and financial services portfolios, why boots-on-the-ground referral networks are a critical and often underutilized growth lever in community care and why many founder-led businesses have attractive CAC economics but are systematically underinvesting in growth. Learn how AI is enabling providers and advisors to spend more time on high-value work—and how to think about tech enablement as a value creation lever rather than a technology roadmap item.The information contained in this podcast is not intended to constitute, and should not be construed as, investment advice.

Major indexes have risen on strong earnings from large technology companies, with Nvidia, Microsoft, Apple, Alphabet, and Meta driving sentiment. Gains are concentrated, and valuations are sensitive to Federal Reserve policy, persistent inflation, and elevated Treasury yields. Some profit improvement reflects cost controls and buybacks, including Apple's $110 billion authorization in 2024. IPO activity has returned selectively, with Arm, Instacart, Klaviyo, and Reddit listing under tighter valuation discipline. Debt remains more expensive than in 2021, affecting runway, M&A, and secondary sales. Investors are rewarding efficient growth, strong retention, fast CAC payback, and free cash flow, while budgets favor AI, data platforms, and security.Learn more on this news by visiting us at: https://greyjournal.net/news/ Hosted on Acast. See acast.com/privacy for more information.

La prudence était de mise hier sur les marchés Entre la situation en Iran et l'imminence de la première décision de Kevin Warsh à la tête de la Réserve Fédérale, les investisseurs étaient peu enclins à la prise de risque.Les opérateurs restaient dans l'attente de connaitre le message et le type de communication qu'adoptera le nouveau président de la FED, pour guider les marchés.Sur le plan géopolitique, l'incertitude demeure avant la signature d'un accord entre Washington et Téhéran.Donald Trump a averti que des frappes pourraient reprendre si le texte final ne lui convenait pas.Résultat, les marchés avançaient sans conviction : peu avant la clôture le CAC 40 cédait 0.20% tandis que le S&P500 faisait du surplace. Quelles sont les actualités du côté des entreprises ?Les valeurs technologiques étaient bien orientées, notamment les semi-conducteurs : Intel, AMD ou encore Broadcom repartent à la hausse après une séance difficile mardi.En revanche en Europe, le constructeur automobile allemand BMW a souffert.Le titre chutait de près de 8% dans l'après-midi après avoir abaissé ses prévisions, sur fond de demande en berne en Chine.Hébergé par Ausha. Visitez ausha.co/politique-de-confidentialite pour plus d'informations.

You spent the money. You signed the case. But can you actually explain which marketing channel deserves the credit? Between billboards, Google, social media, referrals, local maps, streaming ads, and AI search, attorneys misunderstand attribution more than almost any other topic in legal marketing. In this solo episode, Chris Dreyer breaks down why chasing perfect attribution is a losing game, the intake question every firm should ask, and the financial metrics that matter far more than rankings, clicks, or impressions. On this episode, you'll learn: How to calculate Marketing ROI using true client acquisition cost (CAC). What is a good CAC-to-value ratio for personal injury law firms. Which law firm marketing KPIs actually predict revenue growth. How emerging marketing channels affect long-term Marketing ROI. Head over to Rankings.io to discover how we can help you capture more high-value cases. Like what you hear? Hit Subscribe! We do this every week. If you want to keep learning from the best voices in PI, join us at PIMCON 2026. Buy your tickets now! Subscribe to our newsletter and get the freshest news every Monday: newsletter.rankings.io Get Social! Personal Injury Mastermind w/ Chris Dreyer powered by Rankings.io is on Instagram | YouTube | TikTok

Are you scaling your e-commerce brand in revenue, but not in profit? Are you flying blind on CAC, LTV, fulfillment costs, and ad performance, hoping the numbers work out later? Many founders grow to low 7-figures on hustle and luck, only to hit a painful ceiling of chaos, cash-flow problems, and agency fatigue.  In this episode of Marketer of the Day, growth partner Cem Atik of Harucon Ventures shows you what it really takes to move from low 7-figures of chaotic growth to predictable, profitable scale. With 13+ years in e-commerce and a track record of stepping into DTC brands “stuck between traction and chaos,” Cem doesn't just run ads, he and his team take equity and full control of marketing, perform deep finance and marketing due diligence, and rebuild growth systems from the inside out. Cem reveals the three bottlenecks he sees in almost every 7- and 8-figure brand: founders who don't know their true CAC and LTV, broken or non-existent third-party tracking and attribution, and a lack of real control over fulfillment, taxes, and operational costs. He explains how, by building a single source of truth for numbers and cohorts, brands can finally make confident decisions about where to cut spend, where to double down, and how aggressively they can acquire new customers. Instead of guessing, you start steering your business with clarity. https://youtu.be/3fHMwV8W1tE?si=WS6EZKQnCQ77GEYj You'll also hear a powerful case study of a brand doing $10M/month that boosted revenue while cutting marketing spend by 20–25% just by fixing structure and supply chain inefficiencies, saving 9% on fulfillment alone. Cem calls his model “marketing for adults”: performance-based, numbers-first, and designed so both sides win only when the business truly grows profitably. Along the way, he shares why humility beats ego when hiring marketers and operators, and why, if you truly control your numbers, you can afford to move fast and even be a little chaotic everywhere else. If you're tired of agency fatigue, unclear profitability, and growth that feels like a gamble instead of a strategy, this conversation will give you a concrete blueprint. You'll discover how to get a grip on your metrics, clean up your ad accounts, and build a team and system that take you from “winging it” at $1–5M to scaling like a pro toward $50M and beyond, without losing your sanity or your margins. Quotes: “Brands that grow from five to fifty million don't do it because they run better marketing; they do it because they did the groundwork that allows them to grow safely.” “If you have control over your numbers, you can be chaotic in everything else, and as long as your execution speed is great, you will still succeed.” “You could be the best email, WhatsApp, Google Ads, or Meta guy, but the only thing that will always win is a good team that's working proactively together.” Contact Details: Connect with Cem Atik on LinkedIn Explore Harucon Ventures Official Website

Dernier jour du G7 à Évian, Trump douche déjà l'initiative de Macron sur Ormuz avant leur dîner d'État ce soir à Versailles. Côté marchés, le vrai rendez-vous est ailleurs : premier FOMC sous Kevin Warsh, avec un dot plot qui pourrait rebattre les cartes sur les taux 2026. SpaceX dépasse Amazon en capitalisation, le bitcoin reprend de la couleur, et le CAC 40 enchaîne sa quatrième séance de hausse. Tour d'horizon complet dans le brief du jour.

Piazza Fari chiude lievemente positiva a 52.500 punti, mentre Dax e Cac 40 registrano cali. SpaceX subisce un'inversione di rotta, mentre Banco BPM e Saipem si distinguono tra i titoli migliori. Learn more about your ad choices. Visit megaphone.fm/adchoices

Caleb's guest is Doug Sirkoch from UpRoute, a marketing agency specializing in the green industry. The conversation focuses on digital advertising strategies for landscaping and hardscaping businesses, specifically highlighting the importance of tracking metrics like customer acquisition cost (CAC) and lifetime value (LTV). Doug explains the mechanics of Google Ads and the auction-based system that determines search rankings, while emphasizing that fundamental business practices like high-quality reviews remain essential. He also touch upon Facebook retargeting and the necessity of having a professional website to convert leads effectively. The episode provides a roadmap for contractors to use paid media as a scalable lever for business growth and diagnostic improvement. Key Takeaways: Calculate your customer acquisition cost and lifetime value to ensure your marketing spend is actually driving long-term profitability. Maintain high-quality website content and professional imagery to establish authority and attract premium, high-paying clients. Differentiate your business from large corporations by prioritizing personal communication and responding to leads as quickly as possible. Commit to a consistent, long-term advertising strategy rather than turning ads on and off to allow search algorithms to optimize your results over time. Implement retargeting campaigns on social media to stay in front of potential customers who have already shown interest in your high-ticket services. Connect with Auman Landscape

High blood pressure is one of the most dangerous and overlooked risks in executive health. Not because it's rare, but because the typical lifestyle of entrepreneurs and executives hides it further. You know your revenue, your margins, and your CAC. But there's a reasonable chance you have no idea what your average blood pressure is, or what's actually driving it.In this episode, Julian breaks down seven specific drivers that push blood pressure up in high-level operators, and none of them involve genetics or the tired "avoid sodium" conversation.We also cover why leaders are the last people to catch this, what the numbers actually mean, and the highest-leverage actions to take for each driver. — Episode Chapter Big Ideas (timing may not be exact) —0:00 — Introduction & why blood pressure is the most overlooked number in a leader's life3:16 — Genetics, salt, and why neither is the real conversation5:03 — The scale of the problem: the global hypertension picture 7:33 — Why leaders are the last to notice their own biological signals10:03 — The "I'm fine" trap and why functioning isn't the same as thriving11:43 — Driver 1: Sleep Apnea18:12 — Driver 2: Visceral Fat22:14 — Driver 3: Insulin Resistance27:29 — Driver 4: Chronic Stress & Sympathetic Overdrive32:51 — Driver 5: Alcohol36:47 — Driver 6: Poor Sleep42:33 — Driver 7: Arterial Stiffness & Vascular Aging47:05 — The Executive Biological Dashboard51:06 — Closing: health and fitness as the ultimate meritocracy— Connect with Julian and Executive Health —LinkedIn — https://www.linkedin.com/in/julianhayesii/X — https://x.com/thejulianhayesDon't let your biology become the bottleneck to the enterprise you're building. Book a private call —https://www.executivehealth.io/contactWebsite — https://www.executivehealth.io/***DISCLAIMER: The information shared is not meant to treat or diagnose any condition. This is for educational, informational, and entertainment purposes. The content here is not intended to replace your relationship with your doctor and/or medical practitioner. Consult your provider before making any decisions.

WGN Radio's John Landecker is joined by President and CEO of Openlands Michael Davidson, architect and Founder of Studio Gang Jeanne Gang, and Eleanor Gorski, CEO & President of the Chicago Architecture Center (CAC) to talk about the latest companion exhibits, “Chicago's Living Habitat” and “Flyway City,” that CAC debuted last Thursday. Listen in while […]

Most e-commerce brands pour everything into getting customers to checkout — and then hand them a generic, one-size-fits-all experience that quietly kills the sale. Avi Moskowitz, co-founder of PDQ, has processed millions of checkouts across top Shopify brands (including Jones Road Beauty), and his diagnosis is blunt: cart abandonment isn't a technical problem. It's an emotional one. And it's leaving $270 billion on the table every year.Inside the episode:Why your checkout is the one place segmentation goes to die — and how personalizing it by customer type (first-time, returning, high-value) can drive an 18% AOV lift or double-digit conversion jumpsThe "WISMO problem": why more than 50% of order-related support tickets arrive the same day the order was placed — and what it tells you about the trust gap you're creating at checkoutThe free shipping threshold mistake almost every brand is making (hint: they copied a competitor who also just guessed)Surprising checkout wins from PDQ's testing: why moving the economy shipping option down one slot meaningfully increased revenue per session — without a single new ad or productHow to think about every order as its own P&L — factoring in CAC, COGS, fulfillm—Sponsored by OMG Commerce - go to https://www.omgcommerce.com/contact and request your FREE strategy session today!—Chapters:[00:00] Intro — The $270B checkout abandonment problem[00:22] Welcome & Guest Introduction: Avi Moskowitz, Co-Founder of PDQ[01:52] Avi's Background: From Craft Beer to SaaS Founder[03:23] COVID Timing & The eCommerce Wake-Up Call[05:09] The Root Cause of Cart Abandonment: Trust, Not Technology[07:27] How PDQ Solves the Checkout Confidence Gap[14:30] Reducing Friction: Shipping, Delivery Dates & Upsells[23:00] Free Shipping Thresholds & AOV Optimization[34:00] Building a Checkout That Converts Like Amazon[43:24] Thinking in Mini P&Ls: Per-Order Profit Optimization[46:26] Personalized Checkout Logic at the Customer Level[48:24] Where to Find PDQ & Get Your Free Checkout Audit—Connect With Brett: LinkedIn: https://www.linkedin.com/in/thebrettcurry/ YouTube: https://www.youtube.com/channel/UCQmbMwBW8LYDfFAqNqlgTGw Website: https://www.omgcommerce.com/ Request a Free Strategy Session: https://www.omgcommerce.com/contactRelevant Links: Avi's LinkedIn: /moskowitzaviPast guests on eCommerce Evolution include Ezra Firestone, Steve Chou, Drew Sanocki, Jacques Spitzer, Jeremy Horowitz, Ryan Moran, Sean Frank, Andrew Youderian, Ryan McKenzie, Joseph Wilkins, Cody Wittick, Miki Agrawal, Justin Brooke, Nish Samantray, Kurt Elster, John Parkes, Chris Mercer, Rabah Rahil, Bear Handlon, JC Hite, Frederick Vallaeys, Preston Rutherford, Anthony Mink, Bill D'Allessandro, Stephane Colleu, Jeff Oxford, Bryan Porter and more

In this episode of One in Ten, host Teresa Huizar speaks with Kristi Westphaln (UCLA School of Nursing) about integrating children's voices into Children's Advocacy Center (CAC) outcome measurement and understanding what healing after abuse means to youth. Westphaln describes her work with the Canopy CAC and a scoping review showing CAC literature emphasizes programmatic measures (forensic interviews, prosecution) more than child perspectives, and how this aligned with the National Children's Alliance Youth Feedback Survey pilot.Time Stamps: Time. Topic 00:00 Kids Are The Experts 01:14 Kristi's CAC Journey 04:19 Why Youth Voices Matter 08:03 Youth Survey Primer 09:07 Three Healing Questions 12:14 Who Joined The Study 17:20 What Healing Means 21:33 Talking And Support 24:35 Pets Faith Justice 31:12 What CACs Can Do 37:14 Trauma Without The Word 39:44 Key Takeaways And Thanks 43:36 Closing And Where To Listen Resources:Talk with me about it: Child and youth perspectives on healing after child abuse - ScienceDirectSupport the showDid you like this episode? Please leave us a review on Apple Podcasts.

Going after a new segment sounds sexy… until you actually try to do it.

Send us Fan MailWhat separates a strong operator from a true leader—and how do you scale success across multiple companies?In this episode of Joey Pinz Conversations, Joey Pinz sits down with seasoned tech executive Jim Lippie to break down decades of experience across MSPs, SaaS companies, and multiple successful exits. From early days in the MSP space to leading SaaS growth and navigating acquisitions, Jim shares practical insights on leadership, metrics that matter, and what most operators overlook.

You don't usually hear someone talk about peptide serums, CAC and customer lifetime value in the same breath. But that's a normal day for Alexa Raff, CMO of goop, the wellness and lifestyle brand co-founded and led by Gwyneth Paltrow.

Are you burning your marketing budget on a strategy that doesn't actually match your business model? In this video, we break down the critical operational differences between Demand Generation vs. Demand Fulfillment—and how misidentifying your business model completely breaks your content strategy. Whether you're an established founder or managing a middle-market private equity platform, understanding this framework dictates your customer acquisition costs (CAC) and overall scalability.Let's discuss your content infrastructure. Let's connect:instagram.com/frhart2

Jason Kutasi is the founder and CEO of SkyHouse, a performance marketing agency that managed $50M in ad spend for 2025 - its first full year of business. He's driven roughly $500M in advertising over his career and built a children's book publisher acquired by Scholastic and a digital marketing platform acquired by Capital One.  Jason specializes in copywriting, funnel analytics, and scaling high-growth DTC and telemedicine brands.Highlight Bullets> Here's a glimpse of what you would learn…. E-commerce growth strategies and challenges.Comparison of selling on Amazon versus Shopify.Importance of average order value (AOV) in scaling advertising.Strategies to increase AOV, such as product bundling and premium versions.The role of TikTok and other platforms in e-commerce marketing.Managing advertising campaigns and the balance between creative volume and quality.The significance of agency versus in-house marketing teams.The impact of AI on marketing and the importance of human expertise.Insights on effective copywriting and video content in advertising.The future of e-commerce marketing and the evolving landscape of digital advertising.In this episode of the E-comm Breakthrough Podcast, host Josh Hadley speaks with Jason Kutasi, CEO of Skyhouse, about scaling e-commerce brands. They discuss the importance of average order value (AOV), emphasizing that brands need at least $60 in margin to run profitable paid ads. Jason contrasts Amazon-first versus Shopify-first strategies, recommends bundling and subscriptions to boost AOV, and advises starting with freelancers before scaling with agencies and in-house teams. They also explore Meta advertising, creative quality versus volume, and how AI augments—but doesn't replace—skilled marketers and copywriters.Here are the 3 action items that Josh identified from this episode:Fix Your AOV Before Scaling Ads Don't run paid ads until your average order value and margins can support CAC. Aim for $60+ margin per order using bundles, upsells, or subscriptions.Build on Shopify, Use Amazon as a Bonus Channel Prioritize DTC (Shopify) to control pricing, data, and AOV—then layer Amazon as an incremental revenue stream, not your foundation.Test Creatives Broadly, Then Double Down on Winners Launch multiple ad variations quickly, identify what works, and scale only high-performing creatives with better production and audience targeting.Timestamps:00:00:00 Introduction to the AOV ProblemJason Kutasi explains that Amazon sellers often struggle to scale on other platforms due to a low Average Order Value.00:00:34 Host & Guest IntroductionHost Josh Hadley introduces the episode's topic and guest Jason Kutasi, founder and CEO of performance marketing agency Skyhouse.00:02:26 Amazon vs. Shopify MindsetA discussion on the two primary approaches to starting an e-commerce business and the challenges faced by Amazon-first brands.00:03:39 The $60 Margin RuleJason explains why brands need at least $60 in margin to profitably acquire customers on paid ad platforms like Meta.00:04:37 Strategies to Increase AOVActionable ways to increase Average Order Value, including creating sister brands, bundling products, and offering aggressive subscription models.00:07:56 The "Shopify First" AdvantageThe benefits of a higher AOV, which provides more margin to scale advertising across multiple channels beyond Amazon PPC.00:10:30 Why You Must Be OmnichannelJason argues that Shopify brands should sell on Amazon to avoid losing customers who prefer to purchase there.00:14:01 Case Study: A Massive Meta Ad WinJason details a recent successful video ad campaign that scaled to thousands of orders in a single weekend.00:20:04 Navigating Meta's Andromeda UpdateA discussion on Meta's shift to creative-driven campaigns and the strategy of slicing avatars for better, more stable performance.00:23:34 Agency vs. In-House TeamsJason breaks down when to hire a freelancer, an agency, or build an in-house team for your marketing efforts.00:29:13 Why Most Marketing Agencies FailJason shares his experience with underperforming agencies and what brand owners should look for when hiring one.00:33:28 Building an In-House Team Alongside an AgencyThe importance of building an internal team to de-risk your business and test new offers before scaling with an agency.00:36:38 The Future of E-commerce and AIJason predicts AI will commoditize ad creation, making predictive modeling and data-driven rules the new competitive edge.00:41:42 AI as a Human AmplifierAI won't replace skilled marketers but will augment their abilities, allowing them to perform at a much higher level.00:44:43 Three Actionable TakeawaysThe host summarizes the episode's key lessons: fix your AOV, build in-house, and leverage AI with smart people.00:49:33 Jason's Final RecommendationsJason shares his most influential book, favorite AI tool (Claude Code), and a respected figure in the e-commerce space.Resources mentioned in this episode:Josh Hadley on LinkedIneComm Breakthrough ConsultingeComm Breakthrough PodcastEmail Josh Hadley: Josh@eCommBreakthrough.comTools and Websites"Amazon": "00:02:26""Shopify": "00:02:26""Meta (Facebook/Instagram Ads)": "00:02:56""Google Ads": "00:02:56""YouTube Ads": "00:02:56""TikTok": "00:06:23""PayPal": "00:11:49""Apple Pay": "00:11:49""Google Pay": "00:11:49""Shop Pay": "00:11:49""Claude Code": "00:50:05""Meta": "00:38:16"Books"The E-Myth by Michael E. Gerber": "00:00:56""Cash Flow": "00:49:36"Videos"Video Ads": "00:14:01"Notable Mentions / People"Skyhouse (Jason Kutasi's performan...

Performance marketers are running out of levers — and the one most teams haven't pulled yet is signal. In this episode, we speak with Shumel Lais , Founder of Day30, about signal engineering and why it may be the most important skill in performance marketing right now. Shumel explains what signal engineering actually is, how prediction models use behavioural data to identify high-value users before they ever convert, and why synthetic events — goals you engineer rather than observe — help ad platforms like Meta find better users faster. He also shares how subscription apps have achieved up to 50% reductions in CAC, and why, with everything else becoming automated, signal is now one of only two levers performance marketers still control. If you work in user acquisition or subscription growth, this is a must-listen. Today's topics include: What signal engineering is — and how it differs from simply tracking conversion events How prediction models use behavioural data to score users by conversion probability Synthetic events — engineering goals that don't yet exist to give ad platforms a sharper target Why subscription apps generate the behavioural data depth that makes signal engineering work The three components of an effective signal: volume, velocity, and precision Why performance marketers are down to just two levers — creative and signal Links and Resources: Shumel Lais on LinkedIn Day30 Business Of Apps - connecting the app industry Quotes from Shumel Lais “The concept of signal engineering is to see how we can manipulate that event to give the ad platforms a stronger correlation to the business value that you're after." "A synthetic event is, ultimately, when we're creating an event that doesn't actually exist. These are not things that have actually occurred — but based on the data we take in, we can build this from scratch." "When I think of performance marketing now, everything's become very algorithmic and very black box. There's less and less levers available for marketers to pull. I think there's only really two levers left — one is creative, and the second lever is signal." Host Business Of Apps - connecting the app industry since 2012

Neste episódio do Vamos de Vendas, Gustavo Pagotto recebe Nathalia Koga, fundadora da PartnerPro, para uma conversa sobre como profissionalizar a gestão de parcerias, estruturar canais de vendas e transformar ecossistemas em uma fonte previsível de receita.Ao longo do episódio, Nathalia explica por que a maioria das empresas falha ao criar programas de parceiros: falta dedicação, processos claros, tecnologia adequada e uma estratégia consistente de engajamento. Ela mostra como a venda indireta deixou de ser uma alternativa improvisada para se tornar uma das principais alavancas de crescimento em mercados com CAC elevado e pressão por eficiência comercial.A conversa também aborda o papel do gestor de parcerias, as diferenças entre CRM e PRM, os erros mais comuns na estruturação de canais e o passo a passo para criar um programa de parceiros escalável. Nathalia compartilha ainda métricas essenciais para acompanhar a saúde do ecossistema, além de tendências envolvendo automação, inteligência artificial e gestão baseada em dados.

 EPISODE DESCRIPTION I sat down with Brian Gerrard, founder of PaySlice, who spent seven years living across Latin America before building one of the most human-centered fintech startups I have come across. Brian started by connecting friends in emerging markets with remote jobs, then realized they were losing massive chunks of their income to inflation and bad exchange rates. That led him to build PaySlice , a platform that lets workers access their earned wages daily and get paid in stablecoins instead of a depreciating local currency. We talk about how he grew to nearly 10,000 users mostly through word of mouth, why he chose payroll over remittances, how he is embedding PaySlice into gaming and credit apps with zero customer acquisition cost, and where he sees this going as one point two billion people receive a paycheck every month. This is a real conversation about real problems, real traction, and what it actually takes to build something that matters. DISCLAIMERNothing mentioned in this podcast is investment advice and please do your own research. It would mean a lot if you can leave a review of this podcast on Apple Podcasts or Spotify and share this podcast with a friend. Be a guest on the podcast or contact us - https://www.web3pod.xyz/ CONNECT PaySlice Website: https://www.payslice.comBrian Gerrard LinkedIn: https://www.linkedin.com/in/brianjgerrard/Brian Gerrard Email: mailto:brian@payslice.comWeb3 with Sam Kamani: https://www.web3pod.xyz/ KEY POINTS WITH TIMESTAMPS • [00:01] Sam introduces Brian Gerrard from PaySlice and the show's focus on payment infrastructure innovation• [01:36] Brian shares his background , leaving San Francisco to explore Latin America, which turned into a seven-year journey• [02:59] How Brian's staffing agency workers in Argentina, Colombia, and Jamaica asked to be paid daily and in USD, sparking the PaySlice idea• [03:58] PaySlice launches and grows to nearly 10,000 employees on the platform• [05:04] Why stablecoins have real product-market fit , stablecoin transaction volumes now surpassing Visa and Mastercard combined• [07:18] The B2C and B2B sides of PaySlice and which industries are gaining traction, including staffing agencies and payroll companies• [09:30] How traditional payroll tools force-convert currencies and silently take 3.5% from employees without employers knowing• [12:08] How PaySlice acquired most of its users through word-of-mouth and a referral boost mechanic• [13:21] Plans for a physical card launch in 18 countries in Q3 or Q4• [16:34] Brian's growth marketing background at Twitch, where he scaled to 25 million monthly active users• [17:44] Using paid advertising in English and Spanish to target the US-Latin America remittance corridor• [19:08] How analyzing user transaction data via Plaid led to zero-CAC distribution deals with credit repair and mobile gaming companies• [21:03] Companies Brian admires , Revolut and Wise for solving currency frustration at scale• [22:22] The most misunderstood part of crypto-powered payroll and why employers need more empathy toward employees in unstable currencies• [23:05] Founder advice: listen to the market, hold beliefs loosely, and recognize the difference between good struggle and the wrong fit• [30:29] Brian's 10-year vision , getting 1.2 billion monthly paycheck recipients paid every day instead of once a month• [31:27] PaySlice's current seed raise, embedded finance partnership opportunities, and revenue share model

We sit down with Bridget Winston to unpack what separates a real Chief Revenue Officer from a bookings-focused sales leader, and why the org chart tells you the truth faster than the job title. We get practical about SaaS metrics, AI-driven go-to-market, and the leadership habits that keep teams performing as the playbook keeps changing.• Evaluating a CRO remit by reporting lines and revenue accountability• Using GRR and NRR to diagnose product-market fit and ICP clarity• Treating revenue as a lagging indicator of customer centricity• Preparing for LLM-driven discovery with brand, PR, and earned media• Testing AI tools that shrink territory and quota planning cycles• Shifting budget from paid ads to community-led growth and local events• Turning customer testimonials into repeatable social proof loops• Managing humans and AI agents with specific, camera-ready feedback• Fixing incentives and systems before blaming the team• Creating urgency with day-five impact expectations instead of tired 30-60-90 plansYour org chart can tell you whether you're hiring a true Chief Revenue Officer or just renaming a VP of Sales. We sit down with Bridget Winston, CRO at Patient Now and a three-time CRO, to get brutally clear on what revenue ownership actually means and why “bookings” is a dangerous north star when retention and expansion are what compound.We dig into the SaaS metrics that expose reality fast: GRR, NRR, LTV to CAC, and how boards interpret dashboards when product-market fit and ideal customer profile are still shaky. Bridget shares a sharp reframing that stuck with us: revenue is a lagging indicator of customer centricity. From there, we zoom out to the “SaaS-pocalypse” conversation and what happens to pricing, planning cycles, and revenue per employee as AI turns some companies into dinosaurs and others into cheetahs.Then we get tactical about the LLM era of B2B discovery. If buyers are finding software through ChatGPT-style answers, Reddit threads, G2-style reviews, and YouTube, we need consumer-grade brand building, PR, and community-led growth that creates earned media AI can't ignore. Bridget also breaks down AI tools she's used to compress territory planning and quota work from months to weeks, plus AI coaching that improves call quality and handoffs without blowing up day-to-day operations.We even take a fun detour into Spark Tank wine trivia, then bring it back to leadership: how to give feedback with real specificity, fix systems before blaming people, and set expectations for day-one impact. Subscribe, share this with a revenue leader, and leave a review so more builders can find the show.Bridget Winston:  https://www.linkedin.com/in/bridgetwinston/Bridget Winston is the Chief Revenue Officer at PatientNow, leading go-to-market and customer-facing teams across a rapidly growing vertical SaaS platform in the fast-expanding $20 billion aesthetics and wellness industry.  A three-time CRO with over 20 years of experience, Bridget was formerly the CRO at Chief, where she led membership growth and helped the company reach a $1.1 billion valuation. During her tenure, Chief was recognized by TIME as one of the 100 Most Influential Companies and by Fast Company as one of the Most Innovative Companies. Before that, Bridget served as the CRO at Shutterstock, growing revenue to $300 million.Website: https://www.position2.com/podcast/Rajiv Parikh: https://www.linkedin.com/in/rajivparikh/Email us with any feedback for the show: sparkofages.podcast@position2.com

In this episode, we review key updates from the 2026 ACC-AHA Guidelines on the Management of Dyslipidemia. Key Concepts The PREVENT ASCVD equation is now recommended to calculate ASCVD risk, with thresholds at 3%, 5%, and 10%. The previous 7.5% threshold for statin treatment is now 5%. In addition to the 10-year ASCVD estimate, clinicians should consider the use of Lp(a), "risk enhancers", and coronary artery calcium (CAC) scans as a "tie breaker" with shared decision-making when the decision to treat is not clear. In addition to LDL goals of < 100, < 70, or < 55 (depending on risk), the new guidelines also suggest non-HDL-C and apoB goals once LDL cholesterol is at goal. Many patients will require non-statin therapies to achieve lipid goals. The recommended non-statin therapies include ezetimibe, PCSK9 mAb, PCSK9-interfering RNA, and bempedoic acid. References Writing Committee Members, Blumenthal RS, Morris PB, et al. 2026 ACC/AHA/AACVPR/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Dyslipidemia: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2026;153(17):e1154-e1276. doi:10.1161/CIR.0000000000001423 Wiggins BS, Barac A, Benziger CP, et al. 2026 Dyslipidemia Guideline-at-a-Glance. J Am Coll Cardiol. 2026;87(19):2617-2623. doi:10.1016/j.jacc.2026.02.4872 Superko H, Garrett B. Small Dense LDL: Scientific Background, Clinical Relevance, and Recent Evidence Still a Risk Even with 'Normal' LDL-C Levels. Biomedicines. 2022;10(4):829. Published 2022 Apr 1. doi:10.3390/biomedicines10040829

Is your retention making or breaking your lifetime revenue? After the first purchase, most e-commerce brands go quiet — or start blasting discount codes. But the brands that win long-term treat every purchase as the beginning of a relationship, not the end of one. In this episode of Data Beats Opinion, SegMetrics founder Keith Perhac sits down with Ishita Agarwal — founder of Tapp — to dig into why retention is the biggest untapped lever in business, why CAC math is breaking for most brands, and what it actually looks like to turn one-time buyers into loyal fans. What you'll discover: Why your retention tools are only working for 10% of your customers — and what to do about the other 90% From customer to member: the post-purchase mindset shift that changes everything Why discount codes are the wrong retention lever (and what drives real brand loyalty) The CAC math that's quietly bankrupting e-commerce brands — and the LTV fix most brands are ignoring How NFC tags outperform QR codes by 40x — and why physical packaging is an underrated engagement channel About the Guest: Ishita Agarwal is the founder of Tapp, a post-purchase engagement platform that helps e-commerce brands turn one-time buyers into loyal fans. With roots in M&A consulting and emerging technology, she went on to study design and behavioral science at Stanford before zeroing in on the post-purchase gap in commerce. Ishita brings a tech-world playbook — onboarding flows, habit loops, and gamification — to the e-commerce brands that need it most. Connect with Ishita at thetapp.io or on LinkedIn. About SegMetrics: Why Choose SegMetrics?  Instant clarity on what is and isn't working in your business Full-funnel analytics that lets you optimize every marketing touch point for revenue Unify your cross-platform data into a single source of truth Better data → Smarter decisions → Faster growth. Accelerate your growth with SegMetrics. Get Started Today: Learn how SegMetrics can uncover your hidden profits: https://segmetrics.io/ Start a 14-day free trial: https://segmetrics.io/pricing Book a demo: https://segmetrics.io/book-a-demo Chapters (00:00:00) - Meet Ishita Agarwal(00:01:15) - How she got into e-commerce(00:04:59) - Why retention is so broken in e-com(00:07:08) - The math isn't mathing — CAC vs LTV(00:09:01) - Customers vs members(00:11:14) - What Tapp actually does(00:14:38) - Engagement numbers and what they mean(00:17:01) - NFC tags and the omnichannel opportunity(00:20:14) - What brands do with the data(00:22:06) - How personalization works over time(00:27:36) - How engagement turns into sales(00:28:55) - The rewards model (and why discounts don't cut it)(00:32:03) - Stories that make it click — Solidcore and Nintendo Club(00:36:05) - Connecting with customers through Amazon's black box(00:40:20) - The biggest mistake brands make(00:45:42) - The Weber Grill principle(00:47:32) - Where to find Ishita

Click Here to Get All Podcast Show Notes!Most businesses think customer acquisition costs money, but what if you could get paid before a customer even buys? In this episode, Sharran explains how businesses can turn marketing into revenue instead of just spending on acquisition. He introduces the concept of negative CAC (customer acquisition cost) and shows how this approach transforms customer acquisition from a cost center into a profit center.Sharran highlights four big ideas: Acquisition doesn't have to remain expensive, trust changes customer behavior, combining multiple business functions into one system increases efficiency, and attention you own is more valuable than attention you rent. Using examples from workshops, memberships, and social media, he demonstrates how building trust assets before a transaction makes sales faster, easier, and more profitable.This episode provides insights for founders, marketers, and business leaders looking to optimize their customer acquisition, reduce friction, and turn marketing activities into tangible revenue streams.“Whenever one activity performs multiple economic jobs, your business will get dramatically more efficient.”- Sharran SrivatsaaTimestamps:02:06 - Understanding CAC and negative CAC04:27 - How paid workshops generate profit before a sale06:55 - Idea 1: Acquisition doesn't have to stay expensive09:30 - Idea 2: Trust changes customer behavior11:44 - Idea 3: Combine multiple functions into one system13:43 - Idea 4: Attention you own is better than attention you rent16:38 - Recap of the four big ideasResources:- The Next Billion by Sharran Srivatsaa - https://sharransrivatsaa.substack.com/- Acquisition.com - https://www.acquisition.com/- Board Member: ARC Multifamily Real Estate Investing - https://arcmf.com/- Board Member: The Real Brokerage - https://www.joinreal.com/Connect with Sharran:- Facebook - https://www.facebook.com/likesharran- Instagram - https://www.instagram.com/sharransrivatsaa/- X - https://x.com/sharran- LinkedIn - http://www.linkedin.com/in/sharran- YouTube - https://www.youtube.com/channel/UCzpl_gT1bVB1iNZl9yQbWuA?sub_confirmation=1- Threads - https://www.threads.com/@sharransrivatsaa

“All good scientists are skeptics.” — Dr. Anthony Pearson  Key Links  The Skeptical Cardiologist on Substack is HERE   American Heart Association 2026 Guidelines is HERE   MESA CAC Database is HERE   In this episode, I'm joined by Dr. Anthony Pearson, the cardiologist behind The Skeptical Cardiologist newsletter on Substack, for a practical conversation about what women over 50 need to know now about heart health. We talk about the new cholesterol guidelines, why personalized risk assessment matters, and why tests like CAC, Lp(a), and ApoB can reveal much more than a standard lipid panel alone.  What You Will Learn:  Why heart disease is still the number one killer of women  The biggest blind spots women over 50 still have about heart risk  What changed in the new cholesterol guidelines  Why earlier detection and more personalized risk assessment matter  Why CAC, Lp(a), and ApoB are getting more attention  What those tests can reveal that a standard lipid panel may miss  Why statins still matter, despite all the noise around them  When non-statin options may make sense  The role of inflammation in cardiovascular disease  The lifestyle habits that still matter most for prevention  A few key takeaways from this conversation  You can feel healthy, exercise regularly, eat well, and still have hidden cardiovascular risk  A standard cholesterol panel does not always tell the full story  CAC, Lp(a), and ApoB can help create a more complete and individualized picture of risk  High Lp(a) is inherited and is important to know about, even before a specific drug is widely available  ApoB is a more precise marker of atherogenic particles and can add valuable information to routine testing  Statins remain an important, well-studied first-line tool for many people  Prevention works best when you start earlier, not after a cardiac event  Cardio exercise, strength training, and maintaining a healthy body composition all matter  Subscribe to AGE BETTER so you never miss an episode! 

In this episode, Scott Carpenter and Andy “Boy” Miller break down one of the biggest marketing mistakes fitness business owners make: choosing between short-term marketing and long-term brand building instead of using both together.Short-term marketing is direct response — ads, offers, lead forms, consultations, and campaigns designed to get someone to take action now.Long-term marketing is your brand — your reputation, your content, your website, your social media presence, your personal brand, your authority, and the trust you build over time.Scott and Andy explain why direct response can bring in leads now, but can become expensive if your audience is cold and your brand has no foundation. They also explain why brand marketing may not always create immediate sales, but it can dramatically improve your conversions, reduce your acquisition costs, and make people more likely to buy when they are ready.They also cover key marketing numbers every fitness business owner needs to know, including customer acquisition cost, return on ad spend, lifetime customer value, and front-end cash flow.This episode is especially valuable for gym owners, online coaches, chiropractors, and fitness entrepreneurs who want to stop guessing with marketing and start building a strategy that creates both immediate opportunities and long-term growth.Need help building out your marketing plan? Book a 1-on-1 consultation here: https://ptlegends.com/30minadvisorcallKey Takeaways:Direct response marketing gets people to take action now.Brand marketing builds trust, recognition, and long-term demand.Cold traffic is harder to convert when people don't know your brand.Your content, website, and social media help people decide whether they trust you.Personal branding can create more reach than business pages alone.Knowing your CAC, CPA, ROAS, and LTV helps you scale marketing with confidence.Brand marketing and direct response marketing should feed each other.Organic content can create high-ticket opportunities without ad spend.Awareness ads can help grow your audience affordably.The best marketing strategy uses both immediate sales activity and long-term brand building.Like, subscribe, and share this episode with a fitness business owner who needs a better marketing strategy.

Craig Rosenberg, Chief Platform Officer at Scale Venture Partners and co-founder of Topo, joins AJ Bruno and Asad Zaman to take on the question every founder is wrestling with: can you still build a world-class sales team when OpenAI and Anthropic are handing individual contributors $10 million equity packages? Craig argues you do not have to compete head-on, then lays out the hiring profile to chase instead, the quota-to-comp discipline that keeps packages sane, and why founder brand has become the most reliable pipeline play left as CAC keeps climbing. Topics include enterprise AE compensation, where private equity is still winning the GTM talent war, the Topo playbook for events and data-as-moat, and a bull-versus-bear debate on whether Gong goes public in the next 36 months. Plus, a Quiz Pro Quo on the real customer counts behind Salesforce, HubSpot, and ZoomInfo. Key Takeaways: - Rather than try to outbid OpenAI and Anthropic for talent, build your own farm system and develop people into the role. As Craig Rosenberg, Chief Platform Officer at Scale Venture Partners, put it: "You have to change your hiring profile to a unique profile that's unique to your business, but then you gotta coach 'em up." - A resume from a hot AI lab is not a guarantee of success at your company. As Craig Rosenberg noted, "The person that is going to do well at Anthropic may not do well at Series B," so hire for the stage and the hunger rather than the logo. - On compensation, Craig anchors the package to the role's real value: "you pay for what your wedge costs… if you feel like you have to pay $10 million, then you have a huge problem and you gotta go back to the drawing board." If the number runs away from you, the model is broken. - With CAC climbing and most channels breaking down, founder brand has become the highest-leverage pipeline play. As Craig Rosenberg said, "The value of building a founder brand, when you look at the data, it's amazing," pointing to gains in both pipeline and deal size. Connect with the Hosts & Guests: Host: AJ Bruno, CEO at QuotaPath - https://www.linkedin.com/in/ajbruno3/ Host: Asad Zaman, CEO at Sales Talent Agency - https://www.linkedin.com/in/azaman1/ Guest: Craig Rosenberg, Chief Platform Officer at Scale Venture Partners - https://www.linkedin.com/in/craigrosenberg/ Topline is more than a YouTube Channel: Subscribe to Topline Newsletter: https://toplinemedia.substack.com/ Tune into Topline Podcast, the #1 podcast for founders, operators, and investors in B2B tech: https://www.joinpavilion.com/topline-podcast Join the free Topline Slack channel to connect with 600+ revenue leaders to keep the conversation going beyond the podcast: https://www.joinpavilion.com/topline-slack Chapters: 00:00 Introducing Craig Rosenberg 02:34 Can Anyone Out-Hire The AI Labs? 04:33 Why Craig Isn't Worried 06:52 Enterprise AE Comp Is Climbing 08:21 Founders Overpay For Star CROs 10:53 Why AI Reps Struggle At Series B 14:00 Hire The Slighted CRO 14:42 Quota-To-Comp And Attainment 18:45 Can AI Labs Sustain Growth? 22:20 Where PE Still Wins GTM Talent 27:17 Major Runs Reshape GTM 32:36 The Topo GTM Playbook 37:55 Quiz Pro Quo 47:45 Founder Brand And Rising CAC 58:42 Bulls and Bears

The pricing model that built the SaaS industry is being replaced in real time. Is your finance team ready for what it does to your core metrics? In episode #374, Ben Murray breaks down the four SaaS P&L metrics that break when per-seat pricing dies. Public tech leaders are already shifting fast. ServiceNow now drives 50% of net new business from non-seat-based pricing, Workday is reporting hundreds of millions in AI ARR, and GitHub is moving Copilot to usage-based billing. If you are a SaaS CFO or finance leader still modeling on a single blended gross margin, your benchmarks are about to stop working. Why the AI product gross margin sits around 52% and how a 30% revenue mix shift can compress your blended margin by 10 to 15 points How AI COGS scale directly with product usage, breaking the near-zero incremental cost assumption traditional SaaS finance was built on Why one blended LTV no longer works once you have heavy, medium, and light AI usage cohorts, and how to rebuild LTV to CAC by cohort How CAC payback period shifts when gross margin is no longer a single number across the customer base The new frameworks finance teams need to model hybrid subscription plus usage and outcome-based pricing before the board notices the margin compression Tune in to get ahead of the pricing shift before your next forecast and board deck go out. Resources Mentioned Ben's blog post on the SaaS pricing revolution: https://www.thesaascfo.com/saas-per-seat-pricing/ Ben's AI course for SaaS finance leaders: https://www.thesaasacademy.com/ai-finance-metrics-saas

CardioNerds Dr. Joseph Kassab, Dr. Mariana Garcia-Arango, and Dr. Christopher Mason explore the technological revolution of Coronary CT Angiography (CCTA) with expert faculty Dr. Michael Gallagher. The discussion details how CCTA has evolved into a frontline diagnostic and preventive tool, moving beyond simple anatomy to incorporate physiology via CT-FFR and biology through AI-driven plaque quantification. The episode reviews landmark evidence like the SCOT-HEART and PROMISE trials, the nuances of CAD-RADS 2.0 reporting, and the emerging role of AI in monitoring treatment response and personalizing cardiovascular care. Critically, they also discuss some of the assumptions and limitations of these techniques. Stay tuned for a matching review article to be submitted to US Cardiology Review, the official Journal of CardioNerds. This episode was supported by an independent medical education grant from HeartFlow. All CardioNerds education is planned, produced, and reviewed solely by CardioNerds.  Enjoy this Circulation Paths to Discovery article to learn more about the CardioNerds mission and journey. US Cardiology Review is now the official journal of CardioNerds! Submit your manuscripts here. CardioNerds Multimodality Cardiovascular Imaging PageCardioNerds Episode PageCardioNerds AcademyCardionerds Healy Honor Roll Pearls Shift in Paradigm: CCTA is no longer just an anatomic test; with some key limitations, it can provide anatomy, physiology (CT-FFR), and plaque biology (AI-CPA) in a single non-invasive scan. The “Power of Zero” vs. Plaque: While a normal CCTA has a >95% negative predictive value, future MIs often arise from non-obstructive plaque that traditional stress tests might miss. CAD-RADS 2.0 Utility: The addition of plaque burden modifiers (P1–P4) is a “game changer,” allowing clinicians to identify high-risk patients who need aggressive lipid-lowering despite having only mild stenosis. CT-FFR as a Virtual Stress Test: CT-FFR uses computational fluid dynamics to simulate blood flow, potentially reducing unnecessary invasive catheterizations by approximately 61% without sacrificing safety. Seeing the Invisible: AI-based quantitative plaque analysis (QCPA) can identify “subvisual” plaque and low-attenuation (lipid-rich) components that are the primary drivers of acute coronary syndromes. Show Notes How has the role of CCTA changed compared to traditional functional testing? Historically, stress testing answered “is there ischemia today?”, which often reflects late-stage disease. CCTA identifies disease across the entire spectrum, asking “is there atherosclerosis and how much plaque is present?”. Landmark evidence: SCOT-HEART showed a 41% relative risk reduction in MI at 5 years attributed to intensified preventive therapies, and PROMISE showed CCTA was better at selecting patients who truly needed invasive angiography. Diagnostic CCTA imaging depends on the protocol, contrast timing, heart rate, heart rhythm, breathholding, scanner quality, and several patient factors (obesity, prior stents, heavy calcification, complex bypass anatomy, and motion artifact all may limit imaging). “CCTA is exceptional for the right patient, with the right scanner, and the right team.” What are the key modifiers introduced in CAD-RADS 2.0, and why do they matter? CAD-RADS 2.0 moved beyond stenosis severity to include plaque burden (P0 to P4), high-risk plaque (HRP) features, and the presence of ischemia based on CT-FFR. It serves as a clinical decision support tool: a patient with mild (25-49%) stenosis but “extensive” (P4) plaque burden is considered high risk and warrants aggressive risk factor modification. How is CT-FFR calculated, and when is it most useful in clinical practice? CT-FFR uses resting CCTA data and computational fluid dynamics to create a 3D model of coronary flow during simulated maximal hyperemia. It is often used for intermediate lesions (40–90% stenosis) to predict if they are  ischemia-producing, guiding the decision whether to proceed with invasive angiography.  The assumptions necessary for this computational modeling may not apply well to patients with microvascular dysfunction, significant myocardial scar or prior infarction, or ventricular hypertrophy. Still, data indicate that CT-FFR performs similarly to PET in predicting hemodynamically significant lesions.  CT-FFR performs well at the extremes (either clearly normal or clearly abnormal). Accuracy dips, however, in the intermediate range (~0.75-0.80), where decision-making is most critical. In this grey zone, additional factors can help guide the approach, including the amount of myocardium supplied, translesional gradient, and plaque features.   CT-FFR has not been validated in distal segments, stented segments, heavily calcified coronary arteries, or in patients with severe aortic stenosis. Caution with CT-FFR should be utilized in very calcified coronary segments.  What is AI-based quantitative plaque analysis (QCPA), and what metrics are ready for clinical use? This is potentially a paradigm shift, moving away from stenosis-centric thinking to a more disease burden and plaque biology focus. QCPA uses deep learning algorithms to automatically segment the vessel wall and quantify plaque volume in mm³. Ready for “prime time” metrics include: Total Plaque Volume (TPV), non-calcified plaque volume, and Low-Attenuation Plaque (LAP) burden. Can serial CCTA be used to monitor the effectiveness of medical therapies like statins? While not yet a routine guideline-driven practice, trials like PARADIGM and EVAPORATE show that therapies can stabilize plaque; notably, CCTA is better for monitoring than CAC scores, which can be misleading as statins often increase plaque calcification as part of the stabilization process. There are no randomized trials that serial CCTAs improve outcomes. Cost and radiation exposure will be notable limitations. Serial scan timing, scan acquisition and interpretation standardization would be key. Dr. Gallagher notes that we are moving toward a world in which plaque burden may become a “treatment biomarker,” similar to tumor burden in oncology.  References 1. Coronary Computed Tomography Angiography From Clinical Uses to Emerging Technologies: JACC State-of-the-Art Review. Abdelrahman KM, Chen MY, Dey AK, et al. Journal of the American College of Cardiology. 2020;76(10):1226-1243. doi:10.1016/j.jacc.2020.06.076. 2. Non-Invasive Imaging in Coronary Syndromes: Recommendations of the European Association of Cardiovascular Imaging and the American Society of Echocardiography, in Collaboration With the American Society of Nuclear Cardiology, Society of Cardiovascular Computed Tomography, and Society for Cardiovascular Magnetic Resonance. Edvardsen T, Asch FM, Davidson B, et al. Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography. 2022;35(4):329-354. doi:10.1016/j.echo.2021.12.012. 3. 2021 AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR Guideline for the Evaluation and Diagnosis of Chest Pain: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Gulati M, Levy PD, Mukherjee D, et al. Journal of the American College of Cardiology. 2021;78(22):e187-e285. doi:10.1016/j.jacc.2021.07.053. 4. Contemporary, Non-Invasive Imaging Diagnosis of Chronic Coronary Artery Disease. van der Bijl P, Gulati M, Saraste A, et al. Lancet (London, England). 2025;406(10519):2577-2587. doi:10.1016/S0140-6736(25)01586-7. 5. State of the Art: Evaluation and Medical Management of Nonobstructive Coronary Artery Disease in Patients With Chest Pain: A Scientific Statement From the American Heart Association. Slipczuk L, Blankstein R, Bucciarelli-Ducci C, et al. Circulation. 2025;152(23):e443-e466. doi:10.1161/CIR.0000000000001394. 6. Diagnostic Performance of Fractional Flow Reserve Derived From Coronary CT Angiography: The ACCURATE-CT Study. Li C, Hu Y, Jiang J, et al. JACC. Cardiovascular Interventions. 2024;17(17):1980-1992. doi:10.1016/j.jcin.2024.06.027. 7. Clinical Outcomes Based on Coronary Computed Tomography-Derived Fractional Flow Reserve and Plaque Characterization. Sato Y, Motoyama S, Miyajima K, et al. JACC. Cardiovascular Imaging. 2024;17(3):284-297. doi:10.1016/j.jcmg.2023.07.013. 8. Clinical Use of Coronary Computed Tomography Angiography-Derived Fractional Flow Reserve: Expert Consensus by an International Working Group. Tang CX, Leipsic JA, Nørgaard BL, et al. European Radiology. 2026;:10.1007/s00330-025-12313-6. doi:10.1007/s00330-025-12313-6. 9. Diagnostic accuracy of computed tomography–derived fractional flow reserve: a systematic review. Cook CM, Petraco R, Shun-Shin MJ, et al. JAMA Cardiol. 2017;2(7):803-810. Doi:10.1001/jamacardio.2017.1314 10. Diagnostic performance of noninvasive fractional flow reserve derived from coronary computed tomography angiography in suspected coronary artery disease: the NXT trial (Analysis of Coronary Blood Flow Using CT Angiography: Next Steps). Nørgaard BL, Leipsic J, Gaur S, et al. J Am Coll Cardiol. 2014;63(12):1145-1155. Doi:10.1016/j.jacc.2013.11.043 11. Comparison of coronary computed tomography angiography, fractional flow reserve, and perfusion imaging for ischemia diagnosis. Driessen RS, Danad I, Stuijfzand WJ, et al. J Am Coll Cardiol. 2019;73(2):161-173. Doi:10.1016/j.jacc.2018.10.056. 12. 1-year outcomes of FFRCT-guided care in patients with suspected coronary disease: the PLATFORM study. Douglas PS, De Bruyne B, Pontone G, et al. J Am Coll Cardiol. 2016;68(5):435-445. Doi:10.1016/j.jacc.2016.05.057. 13. Comparison of an initial risk-based testing strategy vs usual testing in stable symptomatic patients with suspected coronary artery disease: the PRECISE randomized clinical trial. Douglas PS, Nanna MG, Kelsey MD, et al; PRECISE Investigators. JAMA Cardiol. 2023;8(10):904-914. Doi:10.1001/jamacardio.2023.2595. 14. Diagnostic and clinical value of FFRCT in stable chest pain patients with extensive coronary calcification: the FACC study. Mickley H, Veien KT, Gerke O, et al. JACC Cardiovasc Imaging. 2022;15(6):1046-1058. doi:10.1016/j.jcmg.2021.12.010. 15. Low-Attenuation Noncalcified Plaque on Coronary Computed Tomography Angiography Predicts Myocardial Infarction: Results From the Multicenter SCOT-HEART Trial (Scottish Computed Tomography of the HEART). Williams MC, Kwiecinski J, Doris M, et al. Circulation. 2020;141(18):1452-1462. doi:10.1161/CIRCULATIONAHA.119.044720. 16. AI-Guided Quantitative Plaque Staging Predicts Long-Term Cardiovascular Outcomes in Patients at Risk for Atherosclerotic CVD. Nurmohamed NS, Bom MJ, Jukema RA, et al. JACC. Cardiovascular Imaging. 2024;17(3):269-280. doi:10.1016/j.jcmg.2023.05.020. 17. Interaction of AI-Enabled Quantitative Coronary Plaque Volumes on Coronary CT Angiography, FFRCT, and Clinical Outcomes: A Retrospective Analysis of the ADVANCE Registry. Dundas J, Leipsic J, Fairbairn T, et al. Circulation. Cardiovascular Imaging. 2024;17(3):e016143. doi:10.1161/CIRCIMAGING.123.016143. 18. Prognostic Value of AI-Based Quantitative Coronary CTA vs Human Reader-Based Visual Assessment: Results From the CONFIRM2 Registry. van Rosendael A, Nakanishi R, Bax JJ, et al. JACC. Cardiovascular Imaging. 2026;19(3):345-359. doi:10.1016/j.jcmg.2025.09.021.13. Pericoronary Adipose Tissue as a Marker of Cardiovascular Risk: JACC Review Topic of the Week. Tan N, Dey D, Marwick TH, Nerlekar N. Journal of the American College of Cardiology. 2023;81(9):913-923. doi:10.1016/j.jacc.2022.12.021. 19. Effect of Icosapent Ethyl on Progression of Coronary Atherosclerosis in Patients With Elevated Triglycerides on Statin Therapy: Final Results of the EVAPORATE Trial. Budoff MJ, Bhatt DL, Kinninger A, et al. European Heart Journal. 2020;41(40):3925-3932. doi:10.1093/eurheartj/ehaa652. 20. Coronary CT Angiography Evaluation With Artificial Intelligence for Individualized Medical Treatment of Atherosclerosis: A Consensus Statement From the QCI Study Group. Schulze K, Stantien AM, Williams MC, et al. Nature Reviews. Cardiology. 2026;23(2):100-115. doi:10.1038/s41569-025-01191-6.

“You don't have to be first to be the best.” What does it take to scale a brand from $20M to $140M in just 12 months?  Luka Kvatchrelishvili (CMO, True Sea Moss) joins hosts Connor Rolain (Head of Growth, HexClad) and Connor MacDonald (CMO, Ridge) to break down how he took a bootstrapped, product-led superfood brand … and scaled it into a nine-figure DTC powerhouse. Luka shares his path from practicing law in Georgia to drop shipping foosball tables to leading a 33-person marketing team. The conversation digs into how Luka diagnosed and fixed True Sea Moss' data infrastructure before touching a single ad, and how a surge in creative volume gave way to a more methodical, outcome-driven testing system. He also gets into the halo effect between Meta spend, Amazon, and retail performance; the power of the LTV-to-CAC cohort report; and how True Sea Moss went from Telegram groups and Trello boards to a marketing-led operation scaling toward half a billion.  Powered By Motion Creative Benchmarks 2026 https://motionapp.com/thumbstop-pulse/creative-benchmarks-2026?utm_campaign=marketing-operators&utm_medium=sponsor&utm_content=creative-benchmarks-2026&utm_source=marketing-operators-podcastSaras Analyticshttps://bit.ly/9OP-Ytdesc Haushttps://www.haus.io/operatorsRichpanelhttps://9ops.co/richpanelAftersellhttps://9ops.co/4i3bb5Operators Newsletterhttps://9operators.com/

Episode 2805 - Vinnie Tortorich and Anna Vocino discuss a cholesterol conundrum regarding CAC scores, numbers, and how to naturally balance those numbers. https://vinnietortorich.com/2026/05/a-cholesterol-conundrum-episode-2805 PLEASE SUPPORT OUR SPONSORS Pure Vitamin Club Pure Coffee Club NSNG® Foods VILLA CAPPELLI EAT HAPPY KITCHEN YOU CAN WATCH THIS EPISODE ON YOUTUBE - @FitnessConfidential Podcast Vinnie's workout videos are available to purchase! Choose from a 2-day, 4-day, or 6-day workout–or buy all three at a discount! TO PURCHASE VINNIE'S WORKOUT VIDEOS, CLICK THIS LINK: https://vinnietortorich.com/workout A Cholesterol Conundrum Vinnie recently posted on social media about the Women's Health Initiative. (3:00) The problem with Google is that you can "Google yourself right," so you can always find confirmation bias. There is a growing awareness of what constitutes a "clean" product. (17:00) For example, Anna's spices do not have fillers, preservatives, or anti-caking agents. Vinnie shares a story about a recent consultation. (28:00) CAC scans (calcium score test) are a great guide to see if heart disease will be an issue for you. Repatha was recommended even though the patient's numbers were great, and his calcium score was zero. Consider exploring natural supplements and lifestyle changes to manage cholesterol. The Cholesterol Code movie by Dave Feldman provides good information on cholesterol levels and the benefits of a low-carb diet. Anna goes over some bloodwork numbers and wants to discuss with her doctor. (50:00) Remember that the number ranges given in the results are representative of the general population. (52:00) It is often recommended to take CoQ10 alongside a statin. Statins deplete CoQ10, which can lead to muscle damage. Anna's products are now linked to PureVitamin Club's website. Look under the "Food and Snacks" section so that you can purchase them there, too. (58:30) https://purevitaminclub.com/collections/food-and-snacks The NSNG® VIP GROUP IS NOW CLOSED AGAIN AS OF SUNDAY, MARCH 15TH Anna's next cookbook, Eat Happy Cocktail Hour, is filled with cocktails, mocktails, and appetizers and is available for pre-order right now. If you pre-order, you'll get bonus goodies! You can preorder from a wide variety of booksellers at https://eathappycocktailhour.com/ Save your receipt from wherever you preorder, you'll need it for your bonuses! Physical Release Date is October 2026 A New Sponsor Jaspr Air Scrubbers has a discount code, VINNIE, that gets you $200 off for a limited time. Jaspr offers a lifetime warranty. Go to Jaspr.co for more information or to purchase. (1:05:00) You can book a consultation with Vinnie to get guidance on your goals. https://vinnietortorich.com/phone-consultation-2/ More News Serena has added some of her clothing suggestions and beauty product suggestions to Vinnie's Amazon Recommended Products link. Self Care, Beauty, and Grooming Products that Actually Work! https://www.amazon.com/shop/vinnietortorich/list/3GPVU29UHHPMY?ref_=aipsflist Don't forget to check out Serena Scott Thomas on Days of Our Lives on the Peacock channel. "Dirty Keto" is available on Amazon! You can purchase or rent it here.https://amzn.to/4d9agj1 Please make sure to watch, rate, and review it! Eat Happy Italian, Anna's second cookbook, is available! You can go to https://eathappyitalian.com You can order it from Vinnie's Book Club. https://amzn.to/3ucIXm Anna's recipes are in her cookbooks, on her website, and on Substack —they will spice up your day! https://annavocino.substack.com/ PURCHASE DIRTY KETO (2024) The documentary launched in August 2024! Order it TODAY! This is Vinnie's fourth documentary in just over five years. Visit my new Documentaries HQ to find my films everywhere: https://vinnietortorich.com/documentaries Then, please share my fact-based, health-focused documentary series with your friends and family. Additionally, the more views it receives, the better it ranks, so please watch it again with a new friend! REVIEWS: Please submit your REVIEW after you watch my films. Your positive REVIEW does matter! PURCHASE BEYOND IMPOSSIBLE (2022) Visit my new Documentaries HQ to find my films everywhere: https://vinnietortorich.com/documentaries FAT: A DOCUMENTARY 2 (2021) Visit my new Documentaries HQ to find my films everywhere: https://vinnietortorich.com/documentaries FAT: A DOCUMENTARY (2019) Visit my new Documentaries HQ to find my films everywhere: https://vinnietortorich.com/documentaries

Text Dr. Lenz any feedback or questions The 2026 Cholesterol Revolution: PREVENT Scores, Hidden Risk Markers, and CAC ScansThe script explains how 2026 ACC/AHA guideline changes aim to make heart attacks more preventable by shifting from short-term “10-year risk” thinking to “lower for longer,” precision prevention, and primordial prevention starting earlier in life. It critiques the older Pooled Cohort Equations for underestimating risk in younger people and introduces the PREVENT equation, which adds 30-year risk plus kidney, metabolic, and social factors. It highlights lipoprotein(a) as a largely genetic once-in-a-lifetime test and hs-CRP as an inflammation marker, and emphasizes coronary artery calcium (CAC) scoring as a tiebreaker for statin decisions (0, 1–99, ≥100). Cases illustrate these tools, including tighter LDL goals (

Je reçois le directeur de la banque des CEO et des dirigeants :

This week Kate, Mark and Henry talk about empathetic robots, mother-baby singing groups for postpartum depression, and new American College of Cardiology lipid guidelines.Indiana AFP POEMs course in French Link: https://www.iafp.org/2026ac Empathetic robots: https://pubmed.ncbi.nlm.nih.gov/41359230/ Weekly singing groups for postpartum depression: https://pubmed.ncbi.nlm.nih.gov/41087020/ACC/AHA/etc lipid guidelines: https://pubmed.ncbi.nlm.nih.gov/41824552/A 2025 study in the journal Family Practice finding that the two most trustworthy lipid guidelines recommended against using CAC, while all five less trustworthy guidelines due to poor methods or COI recommended it. Go figure.Smartphones in schools: https://pubmed.ncbi.nlm.nih.gov/41489912/

Your practice is stuck because you don't have enough Qualified Leads to take you to the next level.  In this episode, Dr. Stephen and Dr. Pete unpack the first and often most common bottleneck in practice growth: the inability to consistently attract the right people with the right message at the right time. Through the lens of the Theory of Constraints, they reveal why marketing struggles are rarely solved by simply “doing more marketing” and instead require deeper clarity around purpose, messaging, ideal patient profiles, and measurable systems. From refining the market message that cuts through the noise to understanding Marketing Spend, CAC (Cost to Acquire a Customer) and “Buyer Readiness”, this episode provides a strategic framework for chiropractors who want to stop spraying and praying and start building predictable attraction systems that scale influence, income, and patient impact. In This Episode You Will: Understand why attraction constraints are often the hidden bottleneck in practice growth. Discover how purpose, mission, and vision shape effective marketing systems.  Learn how to create messaging that cuts through marketplace noise and increases readiness.  Clarify the difference between random marketing activity and measurable lead generation.  See how metrics like CAC and LTV create confidence, scale, and strategic decision-making.   Episode Highlights 01:44 - Identify how one primary constraint can quietly suppress growth across an otherwise healthy practice. 03:54 - Discover why true transformation begins when education unlocks awareness rather than simply delivering information. 05:28 - Recognize how unresolved attraction constraints keep practices stuck even when effort and intention remain high. 08:16 - Explore why great coaching often reveals hidden solutions that were already within reach. 11:12 - Clarify why the problem behind the problem must be solved before marketing tactics can produce meaningful growth. 14:23 - Uncover how defining an ideal client profile changes the precision and effectiveness of attraction strategies. 16:36 - Examine the three-part messaging equation required to cut through marketplace noise and create urgency. 18:06 - Reveal how trust-building systems increase patient readiness long before a conversion conversation begins. 20:38 - Differentiate between inconsistent marketing activity and the disciplined repetition required to create momentum. 27:31 - Understand why data-driven marketing eliminates stress and creates confidence in scaling patient acquisition. 28:43 - Dr. Rachel is joined by Dr. Kendall Price of Success Partner Elevate Marketing to unpack what it really takes to turn marketing into a true growth system for modern practices. They explore how Elevate moves beyond generic campaigns by blending brand identity with proven strategies, building trust through every step of the patient journey, and optimizing for real outcomes like patient show rates, not just leads. When marketing becomes intentional, relational, and data-driven, growth shifts from unpredictable to scalable and sustainable.   Resources Mentioned To learn more about the REM CEO Program, please visit:  http://www.theremarkablepractice.com/rem-ceo For more information about Elevate Marketing please visit: https://goelevatemarketing.com/ Book a Strategy Session with Dr. Pete - https://go.oncehub.com/PodcastPC Prefer to watch? Catch the podcast on YouTube at: https://www.youtube.com/@TheRemarkablePractice1 To listen to more episodes, visit https://theremarkablepractice.com/podcast or follow on your favorite podcast app.

Most edible gifting businesses don't work at scale, the logistics are brutal, the margins get squeezed, and the moment quality slips, the whole experience breaks. Rachel Solomon Fascitelli built Boarderie anyway, and it worked.  Rose Hamilton, CEO of Compass Rose Ventures and co-host of The Story of a Brand Show, sits down with Rachel to unpack how a finance background, a COVID pivot, and an obsession with operational precision turned a 2,000 square foot commissary kitchen into one of the most impressive D2C food businesses in America. * A category nobody else wanted — and exactly why she chose it. Rachel saw what others missed: a $100+ year-old edible gifting category that had never been innovated on, wide open for a founder willing to do the hard operational work to get there. * Profitable from day one, on purpose. With a finance mind running the growth engine, Boarderie was never going to be a "grow now, profit later" story. Rachel treated the ad account like a trading account — efficient CAC, disciplined spend, and a relentless focus on the bottom line from the very beginning. * Premium execution is an operations story, not a branding story. Shipping 35,000 handmade boards a day during peak season, with FedEx turning planes around in Memphis to keep up — the wow moment customers experience starts hours before the box ever opens. * Bootstrap founders learn what funded founders often don't. When there's no safety net, you have no choice but to figure it out. Rachel's team did every job themselves — paid media, content, logistics, production — before hiring anyone to do it for them. * Don't build for the coastal bubble. Build for the country. Rachel's sharpest advice for founders: stop chasing what's trendy in New York and LA, and start asking what the rest of America actually needs. That's where the real white space lives. Join us in listening to this episode for one of the most practically useful founder conversations we've had in a while. Rachel doesn't just inspire — she gives you a framework.   From bootstrapping to Shark Tank to scaling dessert as a second category, this is a masterclass in what it really takes to build a profitable, operationally excellent consumer brand.  For more on Boarderie visit: https://boarderie.com/ If you enjoyed this episode, please leave The Story of a Brand Show a rating and review.  Plus, don't forget to follow us on Apple and Spotify.  Your support helps us bring you more content like this!

“The awareness of how lifestyle, diet, and exercise affect us is mind-blowing.” Dr. Giovanni Campanile and Dr. Sandra Cammarata are the founders of CorAeon, the only functional medicine practice founded and led by a husband-and-wife team. Campanile is a Harvard-trained functional cardiologist, Associate Professor of Medicine at Rutgers, New Jersey Medical School, and former cardiologist for the President of the United States, George H.W. Bush. Cammarata is a Tufts-trained functional psychiatrist with 36 years of experience and multiple Castle Connolly Top Doctor honors. Together, they treat cardiovascular health and mental well-being as one inseparable system. They are co-authors of The Sicilian Secret Diet Plan and hosts of the podcast The Rest is Health. 00:00 - The mind-body approach to heart health 03:01 - How relationships predict lifespan 05:18 - The Monday morning heart attack 09:13 - Where healthy people get tripped up 13:02 - Visceral fat & body composition testing 15:28 - Biomarkers beyond cholesterol 23:25 - The problem with a zero CAC score 25:09 - Medications for heart disease risk 28:22 - When stress is the real driver 31:46 - EXO Mind & magnetic brain stimulation 35:34 - The problems with traditional cardiology 41:00 - The benefits of sauna therapy 44:46 - The hidden epidemic: insulin resistance 47:57 - The future of heart health Referenced in the episode:  Harvard longevity study: https://www.adultdevelopmentstudy.org/  This podcast is sponsored by CorAeon, the only functional medicine practice created by a functional cardiologist and functional psychiatrist team for a true mind-body approach. Learn more at coraeon.com.  We hope you enjoy this episode, and feel free to watch the full video on YouTube! Whether it's an article or podcast, we want to know what we can do to help here at mindbodygreen. Let us know at: podcast@mindbodygreen.com. Learn more about your ad choices. Visit megaphone.fm/adchoices