Podcasts about biotech

Use of living systems and organisms to develop or make useful products

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Latest podcast episodes about biotech

OffScrip with Matthew Zachary
Lead (Poisoning), Laugh, Love with Shannon Burkett

OffScrip with Matthew Zachary

Play Episode Listen Later Jan 27, 2026 51:54


Shannon Burkett has lived about six lives. Broadway actor. SNL alum. Nurse. Filmmaker. Advocate. Cancer survivor. And the kind of person who makes you question what you've done with your day. She wrote and produced My Vagina—the stop-motion musical kind, not the cry-for-help kind—and built a global movement after her son was poisoned by lead dust in their New York apartment. Out of that came LEAD: How This Story Ends Is Up to Us, a documentary born from rage, science, and maternal defiance. We talked about everything from The Goonies to Patrick Stewart to the quiet rage of parenting in a country that treats public health like a hobby. This episode is about art, anger, resilience, and what happens when an unstoppable theater nerd turned science geek Jersey girl collides with an immovable healthcare system.RELATED LINKSShannon Burkett Official SiteLEAD: How This Story Ends Is Up to UsEnd Lead PoisoningLinkedIn: Shannon BurkettBroadwayWorld ProfileFEEDBACKLike this episode? Rate and review Out of Patients on your favorite podcast platform. For guest suggestions or sponsorship email podcasts@matthewzachary.com.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Business Of Biotech
BoB@JPM: Ron Cooper, enGene

Business Of Biotech

Play Episode Listen Later Jan 26, 2026 55:57 Transcription Available


We love to hear from our listeners. Send us a message. On this week's episode of the Business of Biotech -- on location at the J.P. Morgan Healthcare Conference -- we're speaking with Ron Cooper, CEO and Board Member at enGene, to unpack how he scaled Albireo from a small research shop to a global commercial company, and why he's now betting on nonviral gene therapy at enGene to help patients with non-muscle invasive bladder cancer keep their bladders. Cooper talks about the importance of keeping development, financing, and hiring in sync as biotech companies grow, his experiences surviving near-death cash deficits, the importance of investing early in CMC, and what to expect in 2026.  Access this and hundreds of episodes of the Business of Biotech videocast under the Business of Biotech tab at lifescienceleader.com. Subscribe to our monthly Business of Biotech newsletter. Get in touch with guest and topic suggestions: ben.comer@lifescienceleader.comFind Ben Comer on LinkedIn: https://www.linkedin.com/in/bencomer/

BioCentury This Week
Ep. 346 - 2026 Public Markets Preview

BioCentury This Week

Play Episode Listen Later Jan 23, 2026 30:54 Transcription Available


The biotech bull is back, and buysiders believe this market has staying power for the first time in nearly five years. On a special episode of the BioCentury This Week podcast, Director of Biopharma Intelligence Stephen Hansen and colleagues discuss Hansen's 2026 Public Markets Preview, which found interest rates, policy in Washington and fundamentals finally aligning and a wave of launches and M&A that could keep capital flowing into the sector.View full story: https://www.biocentury.com/article/658154#BiotechBullMarket #PublicMarkets #BiotechMA #IPOOutlook #FDApolicy00:00 - Introduction00:41 - Market Sentiment07:55 - Biotech's Next Wave14:47 - Lingering Concerns23:29 - IPOs26:47 - M&ATo submit a question to BioCentury's editors, email the BioCentury This Week team at podcasts@biocentury.com.Reach us by sending a text

CareTalk Podcast: Healthcare. Unfiltered.
What JPM Signals for Healthcare in 2026

CareTalk Podcast: Healthcare. Unfiltered.

Play Episode Listen Later Jan 23, 2026 24:16 Transcription Available


Send us a textAI, GLP-1s, federal policy, and China. Those themes dominated last week's JP Morgan Health Care Conference in San Francisco. But what, if anything are the implications for the broader healthcare world in 2026?Hosts David Williams, President of Health Business Group, and John Driscoll, Chairman of UConn Health discuss what stood out most at JPM, including why the GLP-1 wave may be entering a new phase, how Big Tech and AI are reshaping the healthcare landscape, and why China's growing presence in biotech is becoming harder to ignore.

The Acquirers Podcast
Andrew Summers of Summers Value Partners on healthcare, biotech $GILD, $QURE and $ELMD | S08 E02

The Acquirers Podcast

Play Episode Listen Later Jan 22, 2026 59:55


Value: After Hours is a podcast about value investing, Fintwit, and all things finance and investment by investors Tobias Carlisle, and Jake Taylor. ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Soldier of Fortune: Warren Buffett, Sun Tzu and the Ancient Art of Risk-Taking⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ (⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Kindle⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠)We are live every Tuesday at 1.30pm E / 10.30am P.See our latest episodes at https://acquirersmultiple.com/podcastAbout Jake Jake's Twitter: https://twitter.com/farnamjake1Jake's book: The Rebel Allocator https://amzn.to/2sgip3lABOUT THE PODCASTHi, I'm Tobias Carlisle. I launched The Acquirers Podcast to discuss the process of finding undervalued stocks, deep value investing, hedge funds, activism, buyouts, and special situations.We uncover the tactics and strategies for finding good investments, managing risk, dealing with bad luck, and maximizing success.SEE LATEST EPISODEShttps://acquirersmultiple.com/podcast/SEE OUR FREE DEEP VALUE STOCK SCREENER https://acquirersmultiple.com/screener/FOLLOW TOBIASWebsite: https://acquirersmultiple.com/Firm: https://acquirersfunds.com/ Twitter: ttps://twitter.com/GreenbackdLinkedIn: https://www.linkedin.com/in/tobycarlisleFacebook: https://www.facebook.com/tobiascarlisleInstagram: https://www.instagram.com/tobias_carlisleABOUT TOBIAS CARLISLETobias Carlisle is the founder of The Acquirer's Multiple®, and Acquirers Funds®. He is best known as the author of the #1 new release in Amazon's Business and Finance The Acquirer's Multiple: How the Billionaire Contrarians of Deep Value Beat the Market, the Amazon best-sellers Deep Value: Why Activists Investors and Other Contrarians Battle for Control of Losing Corporations (2014) (https://amzn.to/2VwvAGF), Quantitative Value: A Practitioner's Guide to Automating Intelligent Investment and Eliminating Behavioral Errors (2012) (https://amzn.to/2SDDxrN), and Concentrated Investing: Strategies of the World's Greatest Concentrated Value Investors (2016) (https://amzn.to/2SEEjVn). He has extensive experience in investment management, business valuation, public company corporate governance, and corporate law.Prior to founding the forerunner to Acquirers Funds in 2010, Tobias was an analyst at an activist hedge fund, general counsel of a company listed on the Australian Stock Exchange, and a corporate advisory lawyer. As a lawyer specializing in mergers and acquisitions he has advised on transactions across a variety of industries in the United States, the United Kingdom, China, Australia, Singapore, Bermuda, Papua New Guinea, New Zealand, and Guam. He is a graduate of the University of Queensland in Australia with degrees in Law (2001) and Business (Management) (1999).

Papa Phd Podcast
Du PhD à la Stratégie Biotech – Yamina Berchiche sur les Carrières Postdoc

Papa Phd Podcast

Play Episode Listen Later Jan 22, 2026 46:49


Comment passer d'un doctorat en biochimie à un rôle stratégique dans l'industrie biotech ? Dans cet épisode de Beyond the Thesis with Papa PhD (en français), Yamina Berchiche partage son parcours riche et atypique : chercheuse, leader en startup, fondatrice de Doctor GPCR, conseillère stratégique en pharmacologie, et créatrice de communauté. Yamina revient sur les défis de l'après-PhD, les apprentissages de ses expériences en laboratoire et en startup, et sur l'importance d'identifier ses forces pour pivoter en toute confiance vers des rôles hors-académiques. Elle aborde aussi la place du réseautage dans une carrière scientifique, même quand on est introverti·e ou ambiverti·e. Vous apprendrez : • Comment repérer et utiliser vos compétences transférables • Ce que le leadership en startup lui a appris • Pourquoi bâtir une communauté peut transformer une carrière • Des stratégies concrètes pour réseauter sans s'épuiser • Comment évoluer vers une carrière alignée avec vos valeurs

Prime Venture Partners Podcast
2026 Predictions - AI, Robots, Biotech, Unicorns & the Next 5 Years | Prime Ventures Podcast

Prime Venture Partners Podcast

Play Episode Listen Later Jan 21, 2026 55:27


In this special episode of the Prime Venture Partners Podcast, the Partners come together to discuss how AI, new business models, and shifting global dynamics are reshaping startups and what founders should be preparing for as we head deeper into 2026 and beyond. From pragmatic AI adoption to new opportunities in services, SaaS, climate, and governance, this is a grounded conversation on what's actually changing and what still matters.⏱️ Timestamps:00:00 – Introduction01:30 – What Prime Is Willing to Bet On03:20 – AI Models vs Real Value Creation07:35 – Automation, Services and Opportunity11:30 – Moats and Distribution in an AI-First World20:00 – Why Fundamentals Still Matter24:05 – SaaS, Services and India's Global Opportunity28:25 – How AI Will Change Venture Capital37:40 – Predicting the Defining Startups of 203042:05 – Climate, Energy and Big Problems Becoming Solvable45:40 – Boards, Governance and AI Ethics52:10 – Closing Thoughts for Founders Building in 2026

Bio from the Bayou
Episode 120: How to Build Smart Early-Stage Biotech Partnerships That Actually Work

Bio from the Bayou

Play Episode Listen Later Jan 21, 2026 21:37


Trying to form early biotech partnerships but unsure when to say yes, when to push back, or when to walk away? In this episode, host Elaine Hamm, PhD, welcomes back Renee Williams, PhD, MBA, returning to the show as Chief Business Officer at Signify Bio. Drawing from her experience on both sides of the table (as a pharma dealmaker and now an early-stage biotech leader) Renee shares hard-earned insights on how founders can approach partnerships strategically without losing focus, time, or control of their company's story. In this episode, you'll learn: How to evaluate early partnership opportunities and decide which ones are worth your limited time, capital, and attention. Why focus is the most valuable currency for early-stage biotech, especially for platform companies facing constant “what else could this do?” questions. Practical guidance on MTAs, pilot studies, and proof-of-concept work, including how to structure collaborations so they move you closer to a real deal—not just more experiments. Whether you're navigating your first pharma conversation or refining how you partner as a growing biotech company, this episode offers clear, experience-driven advice to help you build partnerships that accelerate progress instead of distracting from it. Links: Connect with Renee Williams, PhD, MBA, and check out Signify Bio. Connect with Elaine Hamm, PhD, and learn about Tulane Medicine Business Development and the School of Medicine. Check out our previous episode with Renee. Connect with Ian McLachlan, BIO from the BAYOU producer. Check out BIO on the BAYOU. Learn more about BIO from the BAYOU - the podcast. Bio from the Bayou is a podcast that explores biotech innovation, business development, and healthcare outcomes in New Orleans & The Gulf South, connecting biotech companies, investors, and key opinion leaders to advance medicine, technology, and startup opportunities in the region.

OffScrip with Matthew Zachary
[WALK IT OFF EP3] CHRONIC ZEN

OffScrip with Matthew Zachary

Play Episode Listen Later Jan 20, 2026 28:17


Michael Kramer was 19 when cancer ambushed his life. He went from surfing Florida beaches to chemo, radiation, and a bone marrow transplant that left him alive but carrying a chronic disease. He had necrosis in his knees and elbows, lost his ability to surf for years, and found himself stuck in hospitals instead of the ocean. Yet he adapted. Michael picked up a guitar, built Lego sets, led support groups, and started sharing his story on Instagram and TikTok.We talk about masculinity, identity, and what happens when the thing that defines you gets stripped away. He opens up about dating in Miami, freezing sperm at a children's hospital, awkward Uber-for-sperm moments with his brother, and how meditation became survival. Michael lost his father to cancer when he was a teen, and that grief shaped how he lives and advocates today. He is funny, grounded, and honest about the realities of survivorship in your twenties. This episode shows what resilience looks like when you refuse to walk it off and choose to speak it out loud instead.RELATED LINKSMichael Kramer on InstagramMichael Kramer on TikTokMichael and Mom Inspire on YouTubeAshlee Cramer's BookUniversity of Miami Sylvester Comprehensive Cancer CenterStupid Cancer FEEDBACKLike this episode? Rate and review Walk It Off on your favorite podcast platform. For guest suggestions or sponsorship inquiries, email podcast@matthewzachary.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Sounds of Science
Beyond The Diagnosis

Sounds of Science

Play Episode Listen Later Jan 20, 2026 25:57


When Patricia Weltin's daughters were diagnosed with Ehlers-Danlos Syndrome after years of uncertainty, she turned her frustration into a global movement. In this episode of Sounds of Science, Patricia shares the story behind Beyond the Diagnosis, a powerful art and advocacy initiative that uses portraiture to humanize rare diseases and inspire empathy in medical professionals, students, and communities around the world. From medical schools to courthouses and even Parisian galleries, the traveling exhibit is reshaping how we see children with rare diseases—not as diagnoses, but as vibrant individuals with stories worth telling. Tune in to hear how Patricia's mission is bridging the gap between science and compassion, and how you can help carry it forward.Show NotesFrom Mystery to Medicine: The Science Behind a Mother's Search | PodcastTaking a Customized and Collaborative Approach to Therapeutic Development | PodcastRare Disease Research for Drug Development | Charles RiverRare Disease | Charles RiverDiscovery | Charles RiverBeyond The Diagnosis

Business Of Biotech
BoB@JPM: Marc Salzberg, M.D., Airway Therapeutics

Business Of Biotech

Play Episode Listen Later Jan 19, 2026 36:08 Transcription Available


We love to hear from our listeners. Send us a message. The Business of Biotech was back in San Francisco for the J.P. Morgan Healthcare Conference (January 12 - 15) and this week we sit down with Marc Salzberg, M.D., CEO, CMO, and Board Chair at Airway Therapeutics, a company developing a recombinant version of human surfactant protein D for several respiratory, inflammatory, and infectious diseases including bronchopulmonary dysplasia (BPD), which is currently in Phase 2b/3 trials. Brian talks about why he selected BPD as a lead clinical indication (a disease primarily affecting preterm infants), what he learned through founding and selling a CRO, how a private biotech funds a pivotal trial across continents, and offers an industry outlook for 2026.   Access this and hundreds of episodes of the Business of Biotech videocast under the Business of Biotech tab at lifescienceleader.com. Subscribe to our monthly Business of Biotech newsletter. Get in touch with guest and topic suggestions: ben.comer@lifescienceleader.comFind Ben Comer on LinkedIn: https://www.linkedin.com/in/bencomer/

Cozen O’Connor Public Strategies - The Beltway Briefing
Episode 367 - In-Conversation: Jamie Metzl on the Superconvergence of the AI, Biotech & Genetics Revolutions

Cozen O’Connor Public Strategies - The Beltway Briefing

Play Episode Listen Later Jan 19, 2026 48:30


Technology and health care futurist Jamie Metzl joins Howard Schweitzer, chief executive officer of Cozen O'Connor Public Strategies, for a wide-ranging conversation on the amazing technological revolutions defining our era. As artificial intelligence, genetics, and biotechnology converge at unprecedented speed, the time between transformative revolutions—from fire and agriculture to industrialization and now AI—continues to shrink. Together, they explore what this superconvergence means for humanity, why innovation is accelerating faster than our institutions, and how the choices made today will shape the future of civilization.

Investor Fuel Real Estate Investing Mastermind - Audio Version
How One Investor Is Combining Real Estate, Biotech, and Health AI Into a Scalable Platform

Investor Fuel Real Estate Investing Mastermind - Audio Version

Play Episode Listen Later Jan 19, 2026 20:53


In this episode of the Real Estate Pros podcast, host Micah Johnson interviews Anton Dormer, the founder of BioLabShare, a pioneering co-living and co-working life science community in Huntsville, Alabama. Anton shares his background in chemistry and medicine, and how he identified a gap in affordable lab space for biotech entrepreneurs. The conversation explores the vision behind BioLabShare, the challenges faced in merging real estate with life sciences, and the importance of building a supportive ecosystem for innovation. Anton also discusses the significance of networking and collaboration in attracting startups to the community, as well as investment opportunities for interested parties.   Professional Real Estate Investors - How we can help you: Investor Fuel Mastermind:  Learn more about the Investor Fuel Mastermind, including 100% deal financing, massive discounts from vendors and sponsors you're already using, our world class community of over 150 members, and SO much more here: http://www.investorfuel.com/apply   Investor Machine Marketing Partnership:  Are you looking for consistent, high quality lead generation? Investor Machine is America's #1 lead generation service professional investors. Investor Machine provides true 'white glove' support to help you build the perfect marketing plan, then we'll execute it for you…talking and working together on an ongoing basis to help you hit YOUR goals! Learn more here: http://www.investormachine.com   Coaching with Mike Hambright:  Interested in 1 on 1 coaching with Mike Hambright? Mike coaches entrepreneurs looking to level up, build coaching or service based businesses (Mike runs multiple 7 and 8 figure a year businesses), building a coaching program and more. Learn more here: https://investorfuel.com/coachingwithmike   Attend a Vacation/Mastermind Retreat with Mike Hambright: Interested in joining a "mini-mastermind" with Mike and his private clients on an upcoming "Retreat", either at locations like Cabo San Lucas, Napa, Park City ski trip, Yellowstone, or even at Mike's East Texas "Big H Ranch"? Learn more here: http://www.investorfuel.com/retreat   Property Insurance: Join the largest and most investor friendly property insurance provider in 2 minutes. Free to join, and insure all your flips and rentals within minutes! There is NO easier insurance provider on the planet (turn insurance on or off in 1 minute without talking to anyone!), and there's no 15-30% agent mark up through this platform!  Register here: https://myinvestorinsurance.com/   New Real Estate Investors - How we can work together: Investor Fuel Club (Coaching and Deal Partner Community): Looking to kickstart your real estate investing career? Join our one of a kind Coaching Community, Investor Fuel Club, where you'll get trained by some of the best real estate investors in America, and partner with them on deals! You don't need $ for deals…we'll partner with you and hold your hand along the way! Learn More here: http://www.investorfuel.com/club   —--------------------

Grow Everything Biotech Podcast
164. From Plasmids to Pallets: How Erin Marasco Scales Biology at Cargill

Grow Everything Biotech Podcast

Play Episode Listen Later Jan 16, 2026 69:15


We kick off our CPG series with Dr. Erin Marasco, Senior Director of Global Biology at Cargill, who leads innovation in ingredient discovery, strain development, and biotech applications. Erin takes us on a fascinating journey from the fundamentals of fermentation to the complexities of scaling biotech products from lab bench to global supply chains. We explore Cargill's 30-year history in biomanufacturing, discuss why terms like "precision fermentation" might be doing more harm than good, and learn what it really takes for startups to partner with multinational companies. Erin shares insights on feedstock diversity across continents, the future of nutritional bioactives in everyday foods, and why success in biotech means moving from "novel" to "preferred." This conversation is essential listening for anyone interested in how biology is quietly transforming every aisle of the grocery store.Grow Everything brings the bioeconomy to life. Hosts Karl Schmieder and Erum Azeez Khan share stories and interview the leaders and influencers changing the world by growing everything. Biology is the oldest technology. And it can be engineered. What are we growing?Learn more at ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠www.messaginglab.com/groweverything⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Chapters:(00:00:00) - Introduction & New Year Kickoff — Welcome to 2026 and the start of our CPG series!(00:01:00) - JP Morgan Conference & South Africa Travel(00:05:00) - New Food Pyramid Controversy(00:10:00) - Introducing Erin Marasco & Cargill's Role in Biotech(00:17:00) - Where Biotech Creates Real Leverage at Cargill(00:21:00) - Demystifying Fermentation: Why Now?(00:26:00) - How Cargill Partners with Startups(00:30:00) - Biggest Misconceptions About Working with Big Companies(00:33:00) - What Product Readiness Means to Cargill(00:38:00) - Plasmids to Pallets: Successful Partnership Examples(00:47:00) - Feedstock Diversity Across Continents(00:53:00) - The Future: Nutrition as Everyday Food(00:58:00) - Quick Fire Questions & Retiring "Precision Fermentation"(01:03:00) - Wrap-Up & What's Next in the CPG SeriesLinks and Resources:CargillCargill Fermentation BlogFermentation: nature's original biotech by CargillCantabria Labs (sunscreen from plant extracts)Viro - Sugarcane StrawsSawubona Mycelium Heliocare Cantabria Labs Andreesen Horowitz, VC fund, raised a $15 billion Topics Covered: biotech, industry, biomanufacturing, bioprocessing, agriculture, agritech, strain engineering, biotech R&D, feedstocks, chemical engineering, bioengineeringHave a question or comment? Message us here:Text or Call (804) 505-5553 Music by: Nihilore Production by:  Amplafy Media

Bio from the Bayou
Episode 119: 2026 Biotech Market Update – What Investors Are Watching Right Now

Bio from the Bayou

Play Episode Listen Later Jan 14, 2026


What's really happening in biotech right now, and where should innovators and investors be paying attention? In this market update episode, host Elaine Hamm, PhD, is joined by guest host Travis Manasco, MD, for a candid conversation on the current state of biotech investing. Together, they unpack where momentum is building, where enthusiasm is cooling, and how founders, scientists, and investors should think strategically as the market finds its footing. From GLP-1s and AI to women's health and preclinical challenges, this episode offers a clear-eyed look at today's biotech landscape—just in time for JPM. In this episode, you'll learn: Which biotech sectors are heating up and why areas like obesity, AI-enabled clinical trials, and women's health are drawing renewed interest Why early-stage and preclinical innovation remains a tough funding environment, despite long-term opportunity How market signals like acquisitions and JPM dynamics may shape biotech strategy in the year ahead Tune in for an honest, insightful market conversation that cuts through the hype and helps you think more clearly about where biotech is headed next. Links: Connect with Travis Manasco, MD, and check out Solas BioVentures. Connect with Elaine Hamm, PhD, and learn about Tulane Medicine Business Development and the School of Medicine. Check out the JP Morgan Healthcare Conference 2026. Check out our previous episode with Travis on AI in Medicine. Connect with Ian McLachlan, BIO from the BAYOU producer. Learn more about BIO from the BAYOU - the podcast. Bio from the Bayou is a podcast that explores biotech innovation, business development, and healthcare outcomes in New Orleans & The Gulf South, connecting biotech companies, investors, and key opinion leaders to advance medicine, technology, and startup opportunities in the region.

OffScrip with Matthew Zachary
[WALK IT OFF EP1] ROCKS NEED ROCKS

OffScrip with Matthew Zachary

Play Episode Listen Later Jan 13, 2026 24:29


Daniel Garza had momentum. Acting roles, directing gigs, national tours lined up. Then anal cancer stopped everything. Radiation wrecked his body, stripped him of control, and left him in diapers, staring down despair. His partner, Christian Ramirez, carried him through the darkest nights, changed his wounds, fought hospitals, and paid the price with his own health. Christian still lives with permanent damage from caregiving, but he stayed anyway.Together they talk with me about masculinity, sex, shame, friendship, and survival. They describe the friendships that vanished, the laughter that kept them alive, and the brutal reality of caregiving no one prepares you for. We get into survivor guilt, PTSD, and why even rocks need rocks. Daniel is now an actor, director, and comedian living with HIV. Christian continues to tell the unfiltered truth about what it takes to be a caregiver and stay whole. This episode gives voice to both sides of the cancer experience, the survivor and the one who stands guard. RELATED LINKSDaniel Garza IMDbDaniel Garza on InstagramDaniel Garza on FacebookChristian Ramirez on LinkedInLilmesican Productions Inc (Daniel & Christian)Stupid Cancer FEEDBACKLike this episode? Rate and review Walk It Off on your favorite podcast platform. For guest suggestions or sponsorship inquiries, email podcast@matthewzachary.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Business Of Biotech
A Royalty Model For Value Creation With Zymeworks' Kenneth Galbraith

Business Of Biotech

Play Episode Listen Later Jan 12, 2026 58:44 Transcription Available


We love to hear from our listeners. Send us a message. On this week's episode of the Business of Biotech, we're speaking with Kenneth Galbraith, CEO and Board Chair at Zymeworks, a biotech developing multispecific therapies internally and through partnerships with companies including Jazz Pharmaceuticals and BeOne Medicines (formerly BeiGene), J&J, Merck, Daiichi Sankyo, and GSK. Ken talks about Zymeworks' shift to a royalty model for development funding and value creation, lessons learned from platform deals and cross-border R&D, the benefits of strong royalty agreements and backloaded milestone payments over headline upfronts, and industry dynamics for the coming year. Ken also shares insights from his deep experiences as a biotech investor and corporate director, and explains why scientific primacy should always drive biotech business decisions.         Access this and hundreds of episodes of the Business of Biotech videocast under the Business of Biotech tab at lifescienceleader.com. Subscribe to our monthly Business of Biotech newsletter. Get in touch with guest and topic suggestions: ben.comer@lifescienceleader.comFind Ben Comer on LinkedIn: https://www.linkedin.com/in/bencomer/

Smart Money Circle
This Biotech CEO Wants To Cure Lung Cancer – Maria Zanes President & CEO bioAffinity Technologies BIAF

Smart Money Circle

Play Episode Listen Later Jan 12, 2026 20:12


This Biotech CEO Wants To Cure Lung Cancer – Maria Zanes President & CEO bioAffinity Technologies BIAF Ticker: BIAF Websitehttps://bioaffinitytech.com/Maria Zannes, Chief Executive Officer, President, and Director, bioAffinity Technologies, Inc. (NASDAQ: BIAF)BioSince founding bioAffinity Technologies in 2014, Ms. Zannes has built a team of award-winning scientists and executives who are advancing breakthrough diagnostics for lung cancer and other pulmonary diseases. The company's first commercial product, CyPath® Lung, is a noninvasive, accurate test for early-stage lung cancer that has proven to detect the disease as early as Stage 1A when it can be cured. Prior to bioAffinity Technologies, Ms. Zannes founded The Zannes Firm to provide strategic solutions for private industry in the medical, environmental and energy fields. Previously, she was President of the Energy Recovery Council, a national trade group and General Manager of ECOS Corporation, a subsidiary of Burlington Environmental. Earlier in her career, she was a legislative aide to Congressman Charles Wilson (D-TX) after having worked as a journalist for Voice of America and the Associated Press. She has been awarded Lifetime Achievement Awards by the American Society of Mechanical Engineers and the Earth Engineering Center Award from Columbia University. Ms. Zannes received her J.D. from the University of Puget Sound in Washington State and is licensed to practice law in New Mexico. bioAffinity Technologies, Inc. (Nasdaq: BIAF)Lung cancer remains the leading cause of cancer deaths worldwide with an estimated 1.8 million deaths annually. Diagnosing and treating early-stage lung cancer can significantly improve outcomes and increase patient survival. bioAffinity Technologies addresses the urgent need for noninvasive, accurate early-stage lung cancer diagnosis. The Company's lead product, CyPath® Lung, accurately detects early-stage lung cancer in high-risk patients as early as Stage 1A. Using CyPath® Lung as part of the diagnostic pathway can lead to earlier diagnosis, fewer unnecessary invasive procedures, reduced patient anxiety, and lower medical costs for the world's largest cancer killer. CyPath® Lung is sold as a Laboratory Developed Test (LDT) by Precision Pathology Laboratory Services, a bioAffinity Technologies company, and reimbursed by Medicare, private payors and federal healthcare systems, including the VA. CyPath® Lung uses proprietary advanced flow cytometry and artificial intelligence (AI) to detect cancer by analyzing the lung microenvironment. CyPath® Lung incorporates a fluorescent porphyrin that is preferentially taken up by cancer and cancer-related cells. The test demonstrated 92% sensitivity, 87% specificity, and 88% accuracy in individuals with small indeterminate pulmonary nodules that often pose diagnostic challenges. The test provides actionable information for physicians to guide next steps in patient care. Physicians using CyPath® Lung for their high-risk patients have reported multiple case studies in which CyPath® Lung detected lung cancer at Stage 1A when standard imaging, risk calculator models and serum marker tests indicated the nodules were likely benign. Conversely, a negative CyPath® Lung result has spared many patients from unnecessary and sometimes risky invasive procedures, including biopsy.

The Top Line
China's biotech moment goes global, Zai Lab exec says (Sponsored)

The Top Line

Play Episode Listen Later Jan 12, 2026 23:44


China has moved from a fast-following biotech market to a source of globally competitive innovation, according to Josh Smiley, president and chief operating officer of Zai Lab. Speaking on The Top Line podcast, Smiley traces the country’s evolution over the past two decades, pointing to regulatory harmonization, expanded national insurance coverage and deepening R&D capabilities as key drivers. He said the most recent wave of Chinese biotechs is no longer focused solely on domestic opportunities but on first- or best-in-class medicines that can compete worldwide, particularly in oncology and immunology. Smiley also details how Zai Lab blends China’s patient access and development speed with global clinical and regulatory standards, a model he says has helped accelerate programs such as Zai’s DLL3-targeted antibody-drug conjugate for small cell lung cancer into late-stage trials. As China-sourced deals now account for a growing share of global biotech partnerships, Smiley argues companies that integrate China early — without treating it as a standalone market — will have a strategic edge. The conversation offers a candid look at what’s next for Zai Lab and why China’s expanding role in drug innovation is likely to reshape the global pipeline for years to come.See omnystudio.com/listener for privacy information.

Fringe Radio Network
Verifiable Evidence: Nanotech Found in Human Bodies with Jesse Beltran - Sarah Westall

Fringe Radio Network

Play Episode Listen Later Jan 10, 2026 78:23 Transcription Available


Jessie Beltran, investigator and expert on directed energy weapons, joins the program to break down the reality behind nanotechnology findings reported in humans around the world—what is known, what is misunderstood, and what evidence actually exists.Beltran is the technical lead of Mind Nexus, an organization dedicated to uncovering hidden technologies, documenting tangible and verifiable evidence, and supporting individuals affected by directed energy exposure and Havana Syndrome / AHI-related phenomena.In this conversation, we explore the technical mechanisms behind these claims, how directed energy research has evolved, what legitimate concerns exist, and where speculation diverges from provable data. Beltran also shares details about Mind Nexus's upcoming documentary and their ongoing investigative work.Learn more about their research and the upcoming documentary at: https://MindNexusLive.comLinks mentioned in the show:Sign up for my newsletter, see exclusives and more at SarahWestall.Substack.comMasterpeace: Protect your body, Remove Heavy Metals including Graphene Oxide and Plastics, and learn more about removing MAC IDs at  https://masterpeacebyhcs.com/shop/?ref=11308Consider subscribing:Follow on TwitterX @Sarah_WestallFollow on my Substack at SarahWestall.Substack.com

Radiolab
Brain Balls

Radiolab

Play Episode Listen Later Jan 9, 2026 41:29


When neuroscientist Madeline Lancaster was a brand new postdoc, she accidentally used an expired protein gel in a lab experiment and noticed something weird. The stem cells she was trying to grow in a dish were self-assembling. The result? Madeline was the first person ever to grow what she called a “cerebral organoid,” a tiny, 3D version of a human brain the size of a peppercorn.In about a decade, these mini human brain balls were everywhere. They were revealing bombshell secrets about how our brains develop in the womb, helping treat advanced cancer patients, being implanted into animals, even playing the video game Pong. But what are they? Are these brain balls capable of sensing, feeling, learning, being? Are they tiny, trapped humans? And if they were, how would we know?Special thanks to Lynn Levy, Jason Yamada-Hanff, David Fajgenbaum, Andrew Verstein, Anne Hamilton, Christopher Mason, Madeline Mason-Mariarty, the team at the Boston Museum of Science, and Howard Fine, Stefano Cirigliano, and the team at Weill-Cornell. EPISODE CREDITS: Reported by - Latif Nasserwith help from - Mona MadgavkarProduced by - Annie McEwen, Mona Madgavkar, and Pat Walterswith mixing help from - Jeremy BloomFact-checking by - Natalie Middleton and Rebecca Randand Edited by  - Alex Neason and Pat WaltersEPISODE CITATIONS:Videos - “Growing Mini Brains to Discover What Makes Us Human,” Madeline Lancaster's TEDxCERN Talk, Nov 2015 (https://zpr.io/6WP7xfA27auR)Brain cells playing Pong (https://zpr.io/pqgSqguJeAPK)Reuters report on CL1 computer launch in March 2025 (https://zpr.io/cdMf8Yjvayyd) Articles - Madeline Lancaster: The accidental organoid – mini-brains as models for human brain development (https://zpr.io/nnwFwUwnm2p6), MRC Laboratory of Molecular Biology What We Can Learn From Brain Organoids (https://zpr.io/frUfsg4pxKsb), by Carl Zimmer. NYT, November 6, 2025Ethical Issues Related to Brain Organoid Research (https://zpr.io/qyiATHEhdnSa), by Insoo Hyun et al, Brain Research, 2020 Brain organoids get cancer, too, opening a new frontier in personalized medicine (https://zpr.io/nqMCQ) STAT Profile of Howard Fine and his lab's glioblastoma research at Weill Cornell Medical Center: By re-creating neural pathway in dish, Stanford Medicine research may speed pain treatment (https://zpr.io/UnegZeQZfqn2) Stanford Medicine profile of Sergiu Pasca's research on pain in organoids A brief history of organoids (https://zpr.io/waSbUCSrL9va) by Corrò et al, American Journal of Physiology - Cell Physiology, Books - Carl Zimmer Life's Edge: The Search for What it Means to be Alive (https://carlzimmer.com/books/lifes-edge/)Sign up for our newsletter!! It includes short essays, recommendations, and details about other ways to interact with the show. Signup (https://radiolab.org/newsletter)!Radiolab is supported by listeners like you. Support Radiolab by becoming a member of The Lab (https://members.radiolab.org/) today.Follow our show on Instagram, Twitter and Facebook @radiolab, and share your thoughts with us by emailing radiolab@wnyc.org.Leadership support for Radiolab's science programming is provided by the Simons Foundation and the John Templeton Foundation. Foundational support for Radiolab was provided by the Alfred P. Sloan Foundation.

Disruption / Interruption
Disrupting Biotech: How DNA Nanorobots Are Rewriting the Rules of Drug Discovery with Jurek Kozyra

Disruption / Interruption

Play Episode Listen Later Jan 8, 2026 30:35


In this episode of Disruption/Interruption, host KJ sits down with Jurek Kozyra, founder and CEO of Nanovery, to explore how DNA nanotechnology and AI are revolutionizing molecular medicine. Discover how tiny nanorobots made from DNA could dramatically accelerate drug development, make diagnostics faster and more affordable, and potentially cure diseases that were previously untreatable. From detecting diseases in hours instead of days to cutting years off the drug development process, this conversation reveals the cutting-edge science that's transforming healthcare. Four Key Takeaways: The Promise of Oligonucleotide Therapeutics (9:06) Traditional medicine targets defective proteins, but many diseases can't be cured because we can't find the right molecule. Oligonucleotide therapeutics target mRNA—the underlying mechanism of disease—meaning you could potentially cure all diseases since all proteins come from mRNA. DNA Nanorobots for Rapid Detection (14:12) Nanovery's DNA nanorobots can detect diseases in blood samples within 2-4 hours compared to traditional lab tests that take two days. These self-assembling machines produce fluorescent signals when they find specific DNA or RNA molecules, enabling point-of-care diagnostics. Accelerating Drug Development (17:13) Pharmaceutical companies race against 20-year patents while drugs take 10+ years to develop. Nanovery's technology provides more accurate data at lower cost and time, potentially shaving years off the development process and helping more drugs successfully reach the market. Real-World Clinical Validation (20:26) In a hospital study with 170 patient samples, Nanovery's technology delivered same or better results than traditional tests in just two hours instead of two days—a game-changer for emergency situations like drug overdoses where immediate answers are critical. Quote of the Show (9:05):"If you can target mRNA very specifically, that means that in theory you could potentially cure all diseases. That's why this area is so exciting right now." – Jurek Kozyra Join our Anti-PR newsletter where we’re keeping a watchful and clever eye on PR trends, PR fails, and interesting news in tech so you don't have to. You're welcome. Want PR that actually matters? Get 30 minutes of expert advice in a fast-paced, zero-nonsense session from Karla Jo Helms, a veteran Crisis PR and Anti-PR Strategist who knows how to tell your story in the best possible light and get the exposure you need to disrupt your industry. Click here to book your call: https://info.jotopr.com/free-anti-pr-eval Ways to connect with Jurek Kozyra: LinkedIn: https://www.linkedin.com/in/j3ny/ Company Website: https://nanovery.co.uk How to get more Disruption/Interruption: Amazon Music - https://music.amazon.com/podcasts/eccda84d-4d5b-4c52-ba54-7fd8af3cbe87/disruption-interruption Apple Podcast - https://podcasts.apple.com/us/podcast/disruption-interruption/id1581985755 Spotify - https://open.spotify.com/show/6yGSwcSp8J354awJkCmJlDSee omnystudio.com/listener for privacy information.

Edge of NFT Podcast
Tokenization in Action The Global Potential & Impact of Real World Asset Digitization

Edge of NFT Podcast

Play Episode Listen Later Jan 7, 2026 30:16


Welcome to this special episode of The Edge of Show, recorded live at the Future of Money, Governance & the Law Summit in Washington, D.C. In this episode, we dive deep into the transformative world of tokenization, exploring its impact on real estate, commodities, and beyond. Join our distinguished panel, moderated by Gerard Dache, featuring industry leaders like Benjamin Diggles, Jack Ding, Chris Smithmyer and Nadia Mihova.Key topics include:The difference between coins and tokensInfrastructure requirements for successful tokenizationReal estate tokenization and its potential to revolutionize transactionsThe importance of trust and governance in blockchain technologyInsights into the Blockchain Maturity Model and its role in selecting the right blockchainTogether, they discuss the essential technology infrastructure for tokenization, real-world use cases, and the future of blockchain in various industries.Don't forget to subscribe, rate, and share this episode with friends who are eager to learn more about the cutting edge of Web3!Support us through our Sponsors! ☕

TechNation Radio Podcast
Episode 658: Episode 25-52 Today’s Biotech Breakthroughs

TechNation Radio Podcast

Play Episode Listen Later Jan 7, 2026 59:00


On this week's Tech Nation, with the 44th Annual J.P. Morgan Healthcare Conference around the corner, we delve into three ongoing efforts in biotech. Moira speaks with Cyriac Roeding and Dr David Suhy, Co-Founders of Earli, about their innovative approach to treating solid tumour cancer. Then, Ketan Mehta of Tris Pharma discusses the potential of a euphoria-suppressing opioid. And Neil Klompas of Augurex Life Sciences talks about a new diagnostic for patients with chronic back pain that pinpoints an easily-missed form of arthritis.BTN TITLE: Can Cancer Cells be Turned Against Themselves?This week on BioTech Nation, Moira speaks with Cyriac Roeding and Dr David Suhy, Co-Founders of Earli, about an innovative new approach to solid tumour cancer. They discuss their effort to turn the cancer cells inside solid tumours into factories that produce their own cancer-fighting therapies.

Empowered Patient Podcast
Reality Check from Biotech Leaders on Using AI in Drug Discovery with BioXcel Therapeutics Gain Therapeutics iBio TRANSCRIPT

Empowered Patient Podcast

Play Episode Listen Later Jan 7, 2026


This roundtable on the role of AI in the biotech sector features Frank Yocca, Senior VP and Chief Scientific Officer at BioXcel Therapeutics, Joanne Taylor, Senior VP for Research at Gain Therapeutics, and Martin Brenner, CEO and Chief Scientific Officer at iBio. The conversation covers the historical adoption of AI in biotech, its current use in drug discovery, and future possibilities.  AI is not a new phenomenon in biotech and has evolved from data processing to sophisticated models that can screen vast amounts of data. There is a critical need for high-quality, structured data to train effective AI models, and these experts caution about the hype surrounding AI-generated discoveries and emphasize the need for real-world biological and human testing. Frank explains, "We are all about AI right from the get-go. We sort of inherited that from the parent company, BioXcel, which is now BioXcel, LLC. The company started by deploying data science on big biomedical and other datasets. Much of the data was unstructured and required significant curation, which at first was largely manual. Later, we began deploying more natural language processing and knowledge graphs to predict whether drugs that initially failed but were safe could be repurposed for other indications. More recently, the latest evolution has really been to use large language models and more agentic workflows to generate hypotheses and insights."   Joanne explains, "So Gain has had for many years, I think 10 years also, a virtual drug discovery platform where we've been able to screen millions of compounds virtually to discover allosteric binding molecules. But about three or so years ago, we made the change from screening millions of compounds to screening, now we're up to the capability of screening trillions of compounds." "We can screen in days, whereas it would take you months and maybe a year to do high-throughput screening. But in terms of having introduced AI into this system, it means that we can do things better because obviously, if you can screen trillions of compounds, you're screening more of the possibilities, you are going to be making better drugs. At least that's the hypothesis than if you are screening fewer compounds. So it's the fact that this is a fast tool set that makes you able to do things that you wouldn't have been otherwise able to do, but it doesn't necessarily make the process itself that much faster because you are doing much more." Martin elaborates, "So we had the good fortune to start from scratch. We're a very small company. We have made from the get-go the decision that our scientists would be bilingual. They're not only data and AI scientists, but they're also biologists. That makes it a lot easier to translate between the two disciplines. We literally started, or Rubrik Therapeutics started, on the hypothesis that would be a model of structure prediction for proteins. So the company was clearly ahead of its time, and we started by making molecules that set up better than existing ones. And that's, I think, a very low hurdle that a lot of people are doing right now. And you hear sometimes this overreaching argument: we make AI drugs. First of all, tomorrow medicines take 10,000 steps, and enabling three of them is not making an AI drug, but making better molecules. This was the first important step." #BioXcel #GainTherapeutics #iBio #AI #ClinicalAI #ArtificialIntelligence #Biotechnology #DrugDiscovery #PersonalizedMedicine #HealthcareInnovation #BiopharmaAI #ClinicalTrials #RareDisease #Neuroscience #PrecisionMedicine #HealthTech #BiotechLeadership #AIinHealthcare #DrugDevelopment #MedicalInnovation bioxceltherapeutics.com  gaintherapeutics.com  ibioinc.com Listen to the podcast here    

Empowered Patient Podcast
Reality Check from Biotech Leaders on Using AI in Drug Discovery with BioXcel Therapeutics Gain Therapeutics iBio

Empowered Patient Podcast

Play Episode Listen Later Jan 7, 2026 47:29


This roundtable on the role of AI in the biotech sector features Frank Yocca, Senior VP and Chief Scientific Officer at BioXcel Therapeutics, Joanne Taylor, Senior VP for Research at Gain Therapeutics, and Martin Brenner, CEO and Chief Scientific Officer at iBio. The conversation covers the historical adoption of AI in biotech, its current use in drug discovery, and future possibilities.  AI is not a new phenomenon in biotech and has evolved from data processing to sophisticated models that can screen vast amounts of data. There is a critical need for high-quality, structured data to train effective AI models, and these experts caution about the hype surrounding AI-generated discoveries and emphasize the need for real-world biological and human testing. Frank explains, "We are all about AI right from the get-go. We sort of inherited that from the parent company, BioXcel, which is now BioXcel, LLC. The company started by deploying data science on big biomedical and other datasets. Much of the data was unstructured and required significant curation, which at first was largely manual. Later, we began deploying more natural language processing and knowledge graphs to predict whether drugs that initially failed but were safe could be repurposed for other indications. More recently, the latest evolution has really been to use large language models and more agentic workflows to generate hypotheses and insights."   Joanne explains, "So Gain has had for many years, I think 10 years also, a virtual drug discovery platform where we've been able to screen millions of compounds virtually to discover allosteric binding molecules. But about three or so years ago, we made the change from screening millions of compounds to screening, now we're up to the capability of screening trillions of compounds." "We can screen in days, whereas it would take you months and maybe a year to do high-throughput screening. But in terms of having introduced AI into this system, it means that we can do things better because obviously, if you can screen trillions of compounds, you're screening more of the possibilities, you are going to be making better drugs. At least that's the hypothesis than if you are screening fewer compounds. So it's the fact that this is a fast tool set that makes you able to do things that you wouldn't have been otherwise able to do, but it doesn't necessarily make the process itself that much faster because you are doing much more." Martin elaborates, "So we had the good fortune to start from scratch. We're a very small company. We have made from the get-go the decision that our scientists would be bilingual. They're not only data and AI scientists, but they're also biologists. That makes it a lot easier to translate between the two disciplines. We literally started, or Rubrik Therapeutics started, on the hypothesis that would be a model of structure prediction for proteins. So the company was clearly ahead of its time, and we started by making molecules that set up better than existing ones. And that's, I think, a very low hurdle that a lot of people are doing right now. And you hear sometimes this overreaching argument, we make AI drugs. First of all, tomorrow medicines take 10,000 steps, and enabling three of them is not making an AI drug, but making better molecules. This was the first important step." #BioXcel #GainTherapeutics #iBio #AI #ClinicalAI #ArtificialIntelligence #Biotechnology #DrugDiscovery #PersonalizedMedicine #HealthcareInnovation #BiopharmaAI #ClinicalTrials #RareDisease #Neuroscience #PrecisionMedicine #HealthTech #BiotechLeadership #AIinHealthcare #DrugDevelopment #MedicalInnovation bioxceltherapeutics.com  gaintherapeutics.com  ibioinc.com Download the transcript here    

Bio from the Bayou
Episode 118: The #1 Survival Guide to the JP Morgan Healthcare Conference for Biotech Leaders

Bio from the Bayou

Play Episode Listen Later Jan 7, 2026 33:22


Want to come back from JP Morgan with more than just a stack of business cards? In this timely episode, host Elaine Hamm, PhD, sits down with Chris Yochim, a longtime JP Morgan Healthcare Conference insider. With more than three decades of experience leading partnering strategy at AstraZeneca and Zeneca, Chris shares a practical, behind-the-scenes look at how the world's most intense healthcare meeting really works—and how to prepare for it effectively. As JP Morgan approaches, Elaine and Chris break down what “success” looks like for different audiences, from academic tech transfer and startups to investors and large pharma. In this episode, you'll learn: How to define “winning” at JP Morgan based on your role—academic, startup, investor, or industry leader. Why preparation, flexibility, and memorable first impressions matter more than a full calendar of meetings. Practical tips for pitching, following up, and building long-term relationships before, during, and after the conference. Whether this is your first JP Morgan or your tenth, this episode offers actionable advice to help you navigate the chaos, build meaningful connections, and turn conversations into real momentum. Links: Check out the JP Morgan Healthcare Conference 2026. Connect with Chris Yochim and check out NIIMBL and AstraZeneca. Connect with Elaine Hamm, PhD, and learn about Tulane Medicine Business Development and the School of Medicine. Check out EBD Group, RESI, and the Guide to JPM'26 app. Connect with James Zanewicz, JD, LLM, RTTP and Dennis Purcell, MBA. Connect with Ian McLachlan, BIO from the BAYOU producer. Learn more about BIO from the BAYOU - the podcast. Bio from the Bayou is a podcast that explores biotech innovation, business development, and healthcare outcomes in New Orleans & The Gulf South, connecting biotech companies, investors, and key opinion leaders to advance medicine, technology, and startup opportunities in the region.

OffScrip with Matthew Zachary
[WALK IT OFF EP1] MAN UP

OffScrip with Matthew Zachary

Play Episode Listen Later Jan 6, 2026 33:17


Trevor Maxwell lived the archetype of masculinity in rural Maine. Big, strong, splitting wood, raising kids, and carrying the load. Then cancer ripped that script apart. In 2018 he was bedridden, emasculated, ashamed, and convinced his family would be better off without him. His wife refused to let him disappear. That moment forced Trevor to face his depression, get help, and rebuild himself. Out of that came Man Up To Cancer, now the largest community for men with cancer, a place where men stop pretending they are bulletproof and start being honest with each other.Eric Charsky joins the conversation. A veteran with five cancers, forty-nine surgeries, and the scars to prove it, Eric lays out what happens when the military's invincible mindset collides with mortality. Together, we talk masculinity, vulnerability, sex, shame, and survival. This episode is blunt, raw, and overdue.RELATED LINKSMan Up To CancerTrevor Maxwell on LinkedInDempsey CenterEric Charsky on LinkedInStupid Cancer FEEDBACKLike this episode? Rate and review Walk It Off on your favorite podcast platform. For guest suggestions or sponsorship inquiries, email podcast@matthewzachary.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

BioCentury This Week
Ep. 342 - 2026 Biotech Kickoff

BioCentury This Week

Play Episode Listen Later Jan 6, 2026 25:53 Transcription Available


The New Year begins with biotech running along parallel storylines. There's cause for optimism as the industry's financing gears have begun to churn again and innovation remains as strong as it has ever been, while there's cause for concern as the world's most stable, progressive, science-based regulatory system has become unpredictable amid new leadership at HHS, FDA, and NIH. On the first episode of the BioCentury This Week podcast's seventh year, BioCentury's analysts assess the state of play for biotech in the U.S., Europe, and Asia.The discussion ranges from recent changes at NIH to what's next for rare pediatric disease priority review vouchers, and from Europe's opportunity as FDA enters uncertain terrain to Japan's evolving biotech landscape.Early bird rates for BioCentury and BayHelix's fifth East-West Biopharma Summit end Friday. Act now to join investors, dealmakers and innovators in Seoul this March to source innovation from Asia, or accelerate your own pipeline by finding the right Asia partner.View full story: https://www.biocentury.com/article/657978#BiotechOutlook #FDAUncertainty #GlobalBiotech #RarePediatricDiseasePRV #NIHLeadership00:00 - Introduction01:46 - 2026 Outlook03:56 - Policy Landscape11:48 - Priority Review Vouchers15:03 - Global Perspectives16:57 - Spotlight on Japan21:55 - European Biotech OpportunitiesTo submit a question to BioCentury's editors, email the BioCentury This Week team at podcasts@biocentury.com.Reach us by sending a text

Deffner & Zschäpitz: Wirtschaftspodcast von WELT
Robotik, Biotech, Immos & Novo – 26 Aktien- und ETF-Ideen für 2026

Deffner & Zschäpitz: Wirtschaftspodcast von WELT

Play Episode Listen Later Jan 6, 2026 127:25


In der ersten Folge des neuen Jahres liefern die Finanzjournalisten Dietmar Deffner und Holger Zschäpitz wieder ihre 26 Investment-Ideen für das Börsenjahr 2026. Der Anspruch ist hoch: In den vergangenen drei Jahren erzielten die Ideen im Schnitt deutlich zweistellige Renditen. Jetzt geht es darum, diese Erfolgsserie fortzuschreiben. DEFFNER & ZSCHÄPITZ sind wie das wahre Leben. Wie Optimist und Pessimist. Im wöchentlichen WELT-Podcast diskutieren und streiten die Journalisten Dietmar Deffner und Holger Zschäpitz über die wichtigen Wirtschaftsthemen des Alltags. Schreiben Sie uns an: wirtschaftspodcast@welt.de Impressum: https://www.welt.de/services/article7893735/Impressum.html Datenschutzerklärung: https://www.welt.de/services/article157550705/Datenschutzerklaerung-WELT-DIGITAL.html

Sounds of Science
Planning For Potential Pandemics: The Coalition for Epidemic Preparedness Innovations

Sounds of Science

Play Episode Listen Later Jan 6, 2026 22:28


As we all learned in 2020, getting ahead of the next major pandemic is a matter of global concern. For the Coalition for Epidemic Preparedness Innovations, or CEPI (cepi.net), it is their reason for existing. Joining me for this conversation are Valentina Bernasconi, Head of Laboratory Science for CEPI, and Marie-Eve Poupart, Lead Scientist In Charles River's Immunology department. Together we discuss CEPI's progress so far, how Charles River is contributing to the cause, and how we can plan for the unknown Disease X while simultaneously handling current outbreaks of deadly diseases like Ebola, Marburg, Nipah virus, Lassa Fever, and chikungunya.

DG Early-Morning Show
Pharma Superintelligence: Dr. Alex Zhavoronkov's Vision for Small Molecules

DG Early-Morning Show

Play Episode Listen Later Jan 6, 2026 77:16 Transcription Available


In this episode, I talked to Dr. Alex Zhavoronkov, CEO of Insilico Medicine, about using AI to generate small molecules for future drugs/therapies, pharma superintelligence, automation of drug discovery, China potentially beating US in biotech innovation, aging, and other funny things, like his head transplant video. ---------------------------------------------------------------Thanks to the sponsors:Audible: Use my link for a 30-day free trial: http://audibletrial.com/diamondgoatNewsly: https://newsly.mepromo code to receive a 1-month free premium subscription: EARLYMORNING Libysn: https://libsyn.compromo code: DG Dubby Energy: https://www.dubby.ggpromo code for 10% off: DIAMONDGOATOpus Clips:  https://www.opus.pro/?via=diamondgoat----------------------------------------------------------------------------------Listen on:Podcast website: https://www.spreaker.com/podcast/dg-early-morning-show--5943922Spotify: https://open.spotify.com/show/0EuhA6WyuerHtVAqcFrFeOPodcast YT channel clips: https://www.youtube.com/@dgearlymorningshowTiktok: @dgearlymorningshowApple Podcast: https://podcasts.apple.com/us/podcast/dg-early-morning-show/id1575451533Amazon Music: https://music.amazon.com/podcasts/f050b86c-1dad-4bc3-b12f-6aa5fa62438c  Goodpods: https://goodpods.com/podcasts/dg-early-morning-show-211830RadioPublic: https://radiopublic.com/dg-earlymorning-show-WoML4rBreaker: https://www.breaker.audio/dg-early-morning-showReason: https://reason.fm/podcast/dg-earlymorning-show--------------------------------------Check out my other stuff:Instagram: @itzdiamondgoatTwitter: @lildiamondgoatMain YT channel: youtube.com/diamondgoatTiktok: @lildiamondgoatSoundcloud: @Lil DiamondgoatSpotify: @Lil DiamondgoatMerch store: https://diamondgoat.creator-spring.comBecome a supporter of this podcast: https://www.spreaker.com/podcast/dg-early-morning-show--5943922/support.

Business Of Biotech
Life Science Connect Editors' Roundtable: Wrapping Up 2025 And Looking Ahead

Business Of Biotech

Play Episode Listen Later Jan 5, 2026 81:12 Transcription Available


We love to hear from our listeners. Send us a message. This week's special holiday episode of the Business of Biotech brings seven chief editors from the Life Science Connect family together to talk about the life sciences industry topics, trips, and reporting that mattered most in 2025, and what each editor has planned for 2026. From the RNA, cell, and gene therapy space to small molecule manufacturing, bioprocessing, drug discovery, and outsourcing, the editors weigh in on key industry trends, new developments, and policy surprises from their respective coverage areas. Topics include biotech funding dynamics, FDA leadership, China's growing role, favorite holiday movies, and much, much more. Special thanks to Tyler Menichiello and the Better Biopharma podcast for hosting this roundtable discussion. Happy New Year!     Access this and hundreds of episodes of the Business of Biotech videocast under the Business of Biotech tab at lifescienceleader.com. Subscribe to our monthly Business of Biotech newsletter. Get in touch with guest and topic suggestions: ben.comer@lifescienceleader.comFind Ben Comer on LinkedIn: https://www.linkedin.com/in/bencomer/

TD Ameritrade Network
2026's "Fire Horse" Market: Robotics, Biotech, Crypto & "Megatrend" Themes

TD Ameritrade Network

Play Episode Listen Later Jan 5, 2026 6:37


Michele Schneider with MarketGuage explains the themes she's watching in what she calls a "fire horse" market this year. She likes robotics, biotech and crypto heading into 2026 and has an eye on small caps. However, Michele urges investors watch for persistent inflation and price impact on everyday goods as a test against American consumers. ======== Schwab Network ========Empowering every investor and trader, every market day. Subscribe to the Market Minute newsletter - https://schwabnetwork.com/subscribeDownload the iOS app - https://apps.apple.com/us/app/schwab-network/id1460719185Download the Amazon Fire Tv App - https://www.amazon.com/TD-Ameritrade-Network/dp/B07KRD76C7Watch on Sling - https://watch.sling.com/1/asset/191928615bd8d47686f94682aefaa007/watchWatch on Vizio - https://www.vizio.com/en/watchfreeplus-exploreWatch on DistroTV - https://www.distro.tv/live/schwab-network/Follow us on X – https://twitter.com/schwabnetworkFollow us on Facebook – https://www.facebook.com/schwabnetworkFollow us on LinkedIn - https://www.linkedin.com/company/schwab-network/ About Schwab Network - https://schwabnetwork.com/about

Culture Architects
48. From Biotech to Climate Action: Building Culture That Scales w/ Brian Cali

Culture Architects

Play Episode Listen Later Jan 5, 2026 52:41


In this episode of Culture Architects, David Friedman interviews Brian Cali, a molecular biologist turned entrepreneur and investor. Brian shares his journey from a young science enthusiast to co-founding Ironwood Pharmaceuticals, emphasizing the importance of relationships, culture, and collaboration in building successful companies. As Ironwood grew, Brian navigated the challenges of maintaining a healthy company culture and adapting to organizational complexity. After a successful career in biotech, he transitioned to climate advocacy, focusing on community building and empowering others to engage in climate action. Brian's story highlights the significance of intentionality in leadership and the ripple effect of decisions made within organizations.

Biotech Career Coach
Quick Momentum For Your 2026 Biotech Career Goals

Biotech Career Coach

Play Episode Listen Later Jan 2, 2026 9:46


January brings fresh biotech hiring budgets, energized hiring managers, and real momentum after a tough 2025. If you've been waiting for the right time to level up your biotech career, this is it.In this episode, you'll discover:Why January is the best month to apply for biotech jobs after a slow DecemberHow the December Networking Challenge helped members grow their LinkedIn reach and profile visibilityThe Application Challenge launches January 6th with five days of live teaching to build daily job search habitsAn annual career planning session on January 12th to map your 2026 goalsA presentation skills workshop that can accelerate both job offers and promotionsA 10-week AI course to help you work smarter and meet employer expectations in 2026The Fire Horse approach to bringing bold, unstoppable energy to your career goalsWhether you're job searching, seeking a promotion, or building new professional skills, this episode gives you the roadmap and momentum to make 2026 your breakthrough year.Join our Biotech Career Coach Skool community and start the year with structure, support, and a community that gets it.Learn more about the Collaboratory Career Hub community and access our free resources:Join our Skool CommunityTake the Free 7-day Interview Sprint ChallengeCheck out our sister podcast: Building BiotechsSend Carina a connection request on LinkedIn!Stay connected with us:

Edge of NFT Podcast
Fueling the Future: Innovation Capitalization Strategies for Web3 Innovation

Edge of NFT Podcast

Play Episode Listen Later Dec 31, 2025 33:36


Welcome to this special episode of The Edge of Show, recorded live at the Future of Money, Governance & the Law Summit in Washington, D.C. This conversation brings together leaders from Web3, finance, policy, and infrastructure to tackle a critical question: how do we fund innovation while building long-term trust, inclusion, and resilience?Moderated by Nadya Rousseau, this panel features Vincent Kadar, Kevin Jackson, Andrew Durgee, and Terry Culver, offering rare insight into how capital formation is evolving through tokenization, public-private collaboration, decentralized infrastructure, and access to private markets.The discussion explores real-world asset tokenization, the role of regulation, the limits of first-mover advantage, and why collaboration, not isolation, is becoming the defining strategy for sustainable innovation. From retail access to pre-IPO assets to DAOs, grants, and hybrid funding models, this episode breaks down how Web3 is reshaping who gets to participate in the global economy.If you're building, investing, shaping policy, or trying to understand where finance and innovation are heading next, this episode delivers clear perspectives from leaders actively building the future not theorizing about it.Support us through our Sponsors! ☕

Nightly Business Report
Final Trading Hours, Biotech's Boom & Buffett's Last Day 12/31/25

Nightly Business Report

Play Episode Listen Later Dec 31, 2025 43:14


As 2025 wraps, we break down the year's top market drivers. Biotech deals dominated the sector, will the M&A momentum continue in 2026? Plus, it's the end of an era for Berkshire Hathaway as Warren Buffett steps down. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Data in Biotech
From discovery to delivery: AI's impact on nanomedicine

Data in Biotech

Play Episode Listen Later Dec 31, 2025 46:31


In this episode of Data in Biotech, Ross Katz chats with Mitra Mosharraf, Chief Scientific Officer at HTD Biosystems, about how AI and machine learning are revolutionizing nanomedicine. They explore the use of AI in drug discovery, formulation, manufacturing, and clinical development, highlighting how data-driven strategies are improving safety, reducing costs, and enabling more personalized therapies in the biotech space. What you'll learn in this episode: >> How AI and ML reduce costs and increase success rates in nanomedicine development. >> Key challenges in nano drug delivery and how machine learning helps overcome them. >> How HTD Biosystems' iFormulate platform speeds up formulation with predictive modeling. >> How wearables and real-time data are reshaping clinical trial design. >> The future of personalized and automated drug delivery systems. Meet our guest Mitra Mosharraf is the Chief Scientific Officer at HTD Biosystems and co-founder of Engimata Inc. With 20+ years of experience, she leads innovation in biologics, nanomedicine, and lipid-based delivery systems. Mitra is a recognized thought leader in pharmaceutical sciences. About the host Ross Katz is Principal and Data Science Lead at CorrDyn. Ross specializes in building intelligent data systems that empower biotech and healthcare organizations to extract insights and drive innovation. Connect with Our Guest: Sponsor: CorrDyn, a data consultancyConnect with Mitra Mosharraf on LinkedIn  Connect with Us: Follow the podcast for more insightful discussions on the latest in biotech and data science.Subscribe and leave a review if you enjoyed this episode!Connect with Ross Katz on LinkedIn Sponsored by… This episode is brought to you by CorrDyn, the leader in data-driven solutions for biotech and healthcare. Discover how CorrDyn is helping organizations turn data into breakthroughs at CorrDyn.

TD Ameritrade Network
Moser: Small Cap Outperformance in 2026, Likes Biotech Including PCRX, SIBN

TD Ameritrade Network

Play Episode Listen Later Dec 31, 2025 6:53


Nathan Moser, Sr. expects GDP to surprise to the upside next year and makes the bull case for U.S. small caps. He especially sees opportunities in biotech and shares several picks, including Pacira Biosciences (PCRX) and SI-Bone (SIBN). “Many of the great medtech companies are eventually acquired,” he notes as well.======== Schwab Network ========Empowering every investor and trader, every market day.Options involve risks and are not suitable for all investors. Before trading, read the Options Disclosure Document. http://bit.ly/2v9tH6DSubscribe to the Market Minute newsletter - https://schwabnetwork.com/subscribeDownload the iOS app - https://apps.apple.com/us/app/schwab-network/id1460719185Download the Amazon Fire Tv App - https://www.amazon.com/TD-Ameritrade-Network/dp/B07KRD76C7Watch on Sling - https://watch.sling.com/1/asset/191928615bd8d47686f94682aefaa007/watchWatch on Vizio - https://www.vizio.com/en/watchfreeplus-exploreWatch on DistroTV - https://www.distro.tv/live/schwab-network/Follow us on X – https://twitter.com/schwabnetworkFollow us on Facebook – https://www.facebook.com/schwabnetworkFollow us on LinkedIn - https://www.linkedin.com/company/schwab-network/About Schwab Network - https://schwabnetwork.com/about

OffScrip with Matthew Zachary
Koby & Hannah's 2025 Holiday Podcast Spectacular

OffScrip with Matthew Zachary

Play Episode Listen Later Dec 30, 2025 28:46


The most anticipated annual tradition on Out of Patients returns with the 2025 Holiday Podcast Spectacular starring Matthew's twins Koby and Hannah. Now 15 and a half and deep into sophomore year, the twins deliver another unfiltered year end recap that longtime listeners wait for every December. What began as a novelty in 2018 has become a time capsule of adolescence, parenting, and how fast childhood burns off.This year's recap covers real moments from 2025 A subway ride home with a bloodied face after running full speed into that tree that grows in Brooklyn. Broadway obsessions fueled by James Madison High School's Roundabout Youth Ensemble access, including Chess, & Juliet, Good Night and Good Luck, and Pirates of Penzance holding court on Broadway. A Disneylanmd trip where the Millennium Falcon triggered a full system reboot. A New York Auto Show pilgrimage capped by a Bugatti sighting. All the things.The twins talk school pressure, AP classes, learner permit anxiety, pop culture fixation, musical theater devotion, and the strange clarity that comes with turning 15. The humor stays sharp, the details stay specific, and the passage of time stays undefeated. This episode lands where the show works best: family, honesty, and letting young people speak for themselves.FEEDBACKLike this episode? Rate and review Out of Patients on your favorite podcast platform. For guest suggestions or sponsorship email podcasts@matthewzachary.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

BioCentury This Week
Ep. 341 - BioCentury's '25-'26 Picks. Plus: BioMarin & Biotech ICYMI

BioCentury This Week

Play Episode Listen Later Dec 30, 2025 38:15 Transcription Available


This past year was an inflection point for biotech: The markets woke up, M&A and China had strong showings, drug development offered key trends, and new leadership at FDA shuffled the regulatory deck. On the latest BioCentury This Week podcast, BioCentury's analysts make their picks for the biggest biopharma readouts, deals and regulatory and policy moves of 2025 and what they are forecasting for the year ahead.The analysts also recap biotech highlights of the past two weeks, including the $4.8 billion takeout of Amicus Therapeutics by BioMarin Pharmaceutical.View full story: https://www.biocentury.com/article/657933#BiotechOutlook2026 #BiopharmaTrends #BiotechMA #FDALeadership #ChinaBiotech00:00 - Introduction 02:31 - BioMarin's $4.8B Amicus Deal06:07 - Year-end Biotech Highlights16:37 - Analyst Picks and Predictions30:01 - Policy and Regulatory LandscapeTo submit a question to BioCentury's editors, email the BioCentury This Week team at podcasts@biocentury.com.Reach us by sending a text

Happen to Your Career
Career Pivot from Biotech Without Starting Over: How Brie Gjurich-Wozniak Built Flexible, Purpose-Driven Work

Happen to Your Career

Play Episode Listen Later Dec 29, 2025 30:44


When a high-achieving scientist realized the traditional definition of success no longer fit, she chose a radically different path. In this episode, Brie shares how she walked away from a predictable biotech career, trusted her instincts, and built a portfolio-style consulting business that aligns with her values, energy, and love for animal welfare.   What you'll learn How to recognize when your "successful" career no longer feels meaningful Why trusting your instincts is essential when your values begin to shift How career experiments (like Social Goldilocks) can reveal unexpected paths What it takes to design a more flexible, values-aligned version of success   Our book, Happen To Your Career: An Unconventional Approach To Career Change and Meaningful Work, is now available on audiobook! Visit  happentoyourcareer.com/audible to order it now! Visit happentoyourcareer.com/book for more information or buy the print or ebook here! Want to chat with our team about your unique situation? Schedule a conversation   Free Resources What career fits you? Join our free 8 Day Mini Course to figure it out! Career Change Guide - Learn how high-performers discover their ideal career and find meaningful, well-paid work without starting over.   Related Episodes Designing Career Experiments and Testing New Careers (Spotify / Apple Podcasts) Discover Your Strengths to Find Your Ideal Career (Spotify / Apple Podcasts) Social Goldilocks Experiment (Watch Here)

Business Of Biotech
Building Cell Therapy Companies With Kenai Therapeutics' Nick Manusos

Business Of Biotech

Play Episode Listen Later Dec 29, 2025 46:39 Transcription Available


We love to hear from our listeners. Send us a message. On this week's episode of the Business of Biotech, Nick Manusos, CEO at Kenai Therapeutics, talks about his experiences building cell therapy spinouts from FujiFilm Cellular Dynamics, learning from big pharma decision-making processes, and dosing the first patient with Kenai's allogeneic neuron replacement cell therapy for Parkinson's disease. Nick also talks about funding an early-stage cell therapy company and forging key manufacturing and therapy administration partnerships. Access this and hundreds of episodes of the Business of Biotech videocast under the Business of Biotech tab at lifescienceleader.com. Subscribe to our monthly Business of Biotech newsletter. Get in touch with guest and topic suggestions: ben.comer@lifescienceleader.comFind Ben Comer on LinkedIn: https://www.linkedin.com/in/bencomer/

Wellness Talk with George Batista
Where Biotech Meets Balance with Dr. Christina Rahm (Replay)

Wellness Talk with George Batista

Play Episode Listen Later Dec 29, 2025 49:24


Dr. Christina Rahm has worked as a medical, clinical, and research scientist in the pharmaceutical, nutraceutical, and biotechnology industries for Janssen, Johnson & Johnson, Biogen Idec/Biogen, UCB, Bristol Meyers Squibb, and Alexion. Additionally, she worked on the corporate side for Pfizer, Biogen, and Janssen and is currently the Chairman of International Science Nutrition Society and Chief Science Officer for ROOT Wellness. Dr. Rahm has also served as a formulator for several companies and manufacturing labs, including her own. She has created multiple provisional patents, proprietary formulas, and trade secrets in addition to authoring her first book, Cure the Causes: Live the Life you Want, Not the One Prescribed. Through years of laboratory research and ethical observations, she has developed a personalized and predictive consulting company working on everything from the environment to DNA and detox wellness plans in which Dr. Rahm helps clients reset their bodies and minds to be spiritually, mentally, emotionally, and physically balanced.

Edge of NFT Podcast
FOMGL Summit 2025: Tokenization, Policy & AI Revolution Live from DC

Edge of NFT Podcast

Play Episode Listen Later Dec 24, 2025 61:50


Welcome to this special Christmas Eve episode of The Edge of Show recorded live at the Future of Money, Governance, and the Law (FOMGL) hosted by Edge of Company with the Government Blockchain Association, this special captures live insights from industry leaders like Yat Siu, Brittany Keisser and Bill Foster on tokenization, blockchain policy, and decentralized ecosystems near the White House. Key TakeawaysYat Siu talks about how tokenization emerges as a transformative force, enabling network ownership, stablecoin expansion to unbanked populations, and AI agency through fixed blockchain rules. Bill Foster addresses permissioned blockchains, identity verification via mobile IDs, and stablecoin risks like bailouts. Brittany Kaiser champions data ownership, Telegram's TON blockchain for ethical social media, and privacy-preserving AI networksDiscussions explore how blockchain, AI, stablecoins, and data rights are reshaping finance, regulation, and global innovation.​We wish you a very Happy Holidays!! Support us through our Sponsors! ☕

OffScrip with Matthew Zachary
Hair Today, Gone Tomorrow: Jason Gilley

OffScrip with Matthew Zachary

Play Episode Listen Later Dec 23, 2025 40:20


Jason Gilley walked into adulthood with a fastball, a college roster spot, and a head of curls that deserved its own agent. Cancer crashed that party and took him on a tour of chemo chairs, pediatric wards, metal taste, numb legs, PTSD, and the kind of late night panic that rewires a kid before he even knows who he is.I sat with him in the studio and heard a story I know in my bones. He grew up fast. He learned how to stare down mortality at nineteen. He found anchors in baseball, therapy, and the strange friendships cancer hands you when it tears your plans apart. He owns the fear and the humor without slogans or shortcuts. Listeners will meet a young man who refuses to let cancer shrink his world. He fights for the life he wants. He names the truth without apology. He reminds us that survivorship stays messy and sacred at the same time. This conversation will stay with you.RELATED LINKS• Jason Gilley on IG• Athletek Baseball Podcast• EMDR information• Children's Healthcare of AtlantaFEEDBACKLike this episode? Rate and review Out of Patients on your favorite podcast platform. For guest suggestions or sponsorship email podcasts@matthewzachary.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

The James Altucher Show
Why Peter Thiel's Founder Rules Keep Paying Off

The James Altucher Show

Play Episode Listen Later Dec 21, 2025 68:04


A Note from James:One of my favorite conversations on this show was with Peter Thiel. Yes—PayPal, Facebook, Palantir, and a dozen other hits. I first ran this episode years ago, and the advice still holds up. The same stories, the same frameworks—and the same challenge to think from first principles. Here's Peter Thiel, one of the most influential entrepreneurs of our time. Episode Description:In this redux, James pressure-tests the core ideas from Peter Thiel's Zero to One—why competition is for losers, how real monopolies are built, and why starting “narrow” is often the only path to something huge. They cover Facebook's early moat (real identity), PayPal's network-effect wedge on eBay, and the “10x or nothing” bar for proprietary technology. Peter shares a contrarian read on bubbles, why biotech's slump may be opportunity, and how to hire, divide roles, and keep teams from fighting. The through-line: seek secrets, combine disciplines, and make something so different that it becomes its own category. What You'll Learn:How to pick markets the Zero to One way: start with a “small, winnable monopoly,” then expand in concentric circles. The four classic moats—and which to favor first: proprietary tech, network effects, economies of scale, and brand (with a bias toward real tech). A practical rule for virality vs. network effects: growth is a tactic; enduring value comes from the network that forms once users arrive. Team design that prevents internal warfare: make roles uniquely owned; if two people own the same thing, you're paying for a fight. How to hunt “secrets”: believe they exist, look where consensus is stale, and borrow from adjacent fields to see what specialists miss. Timestamped Chapters:[02:00] A Note from James — Why this conversation still ranks among the best. [03:00] Zero to One, in one line — “Do something new, different, fresh, strange.” [05:17] Competition vs. Capitalism — Why perfect competition kills profits; aim for uniqueness. [07:28] Facebook's original edge — Real identity as the breakthrough vs. MySpace's alt-persona culture. [09:14] Bits vs. Atoms — Stagnation outside software and how biology could become an information science. [12:05] Personality and perseverance — Why mild contrarian wiring helps founders ignore status games. [15:21] “10x or nothing” — The technology and/or experience must be an order of magnitude better. [17:00] Monopoly thinking, ethically done — Create abundance by creating something truly new. [23:30] The PayPal pre-history — Why long-running trust among teammates births more companies. [30:10] Early Facebook investment logic — College-only looked “small,” which was exactly the point. [32:03] Turning down $1B — The boardroom debate, optionality, and founder conviction. [36:23] Moats in practice — Picking the right advantage (and why brand alone is shaky). [37:06] Network effects ≠ virality — How value compounds after growth. [39:54] PayPal's wedge — eBay power-sellers and the $10 incentive as a growth accelerant. [41:22] Beware the “Chinese refrigerator” TAM slide — Start small, win big. [42:01] Uber vs. Airbnb — Investor bias and why some models get over- or undervalued. [44:18] Bubbles and the public — What changes across tech, housing, and today's “government bubble.” [48:00] War on cash & credit — Why Peter favors unlevered, opaque innovation over fixed income. [51:10] Biotech headwinds (and upside) — Regulation, Eroom's Law, and why sentiment can misprice breakthroughs. [53:50] Secrets — If you assume they exist, you'll be the one to find them. [57:56] Interdisciplinary bets — CS × biology; CS × transportation; why university silos miss the action. [59:51] Silicon Valley on HBO — The “Peter Gregory” caricature and what the show gets right. Additional Resources:Zero to One: Notes on Startups, or How to Build the Future (book) — Amazon hardcover. AmazonFounders Fund — Peter Thiel profile (bio & portfolio highlights). Founders Fund“PayPal Mafia” overview (alumni companies: YouTube, Yelp, LinkedIn, Tesla, SpaceX, Palantir, Yammer). WikipediaYahoo's 2006 $1B offer for Facebook (background reporting). Business InsiderEroom's Law (pharma R&D productivity; Nature Reviews Drug Discovery). NatureSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.