First-Person Science Podcast

#neuroscience #psilocybin #MDMA #depression #psychedelicmedicine From NeuroBeer #4 - streamed live June 15, 2020. Full conversation: https://youtu.be/yhxyuBLiLs8 Do you need to have a psychedelic trip to experience the beneficial therapeutic actions of psychedelics? How long does it take for psychedelic drugs like MDMA or magic mushrooms (psilocybin) to have therapeutic effects for depression or ptsd treatment? How long do these antidepressant actions of MDMA & psilocybin last? And How do these psychedelic drugs produce their beneficial effects in the brain to begin with? Serotonin receptors vs metabotropic glutamate receptors involved? These highly anticipated results follow-up with patients treated with MDMA-assisted psychotherapy 1+ years after treatment to evaluate how long the benefits last for.  These freshly published results are derived from six separate phase 2 clinical trials that were published June 3rd in the journal Psychopharmacology.We're a group of Canadian neuroscientists reviewing the latest news, events and scholarly publications from this week in neuroscience and beyond! In each NeuroDrugs live stream we review classics in the field of addiction neuroscience, as well as newly published articles on a weekly basis. In this clip we comment on the recent phase-2 follow up studies from the Multidisciplinary Association For Psychedelic Studies (MAPS). In September 2019 the first results from pooled analyses of 6 double blinded and randomized studies assessing MDMA for PTSD management entitled, "Breakthrough for Trauma Treatment: Safety and Efficacy of MDMA-Assisted Psychotherapy Compared to Paroxetine and Sertraline". More than 1 year has passed since the initial trials were completed, and in June 2020 the  results from the 1+ year follow up study of these same individuals were reported. We explore these results and possible mechanisms underlying MDMA and psilocybin assisted psychotherapy for depression and ptsd. open access article phase-2 follow up study: https://link.springer.com/article/10.1007/s00213-020-05548-2 Original Phase 2 pooled analysis: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751381/ Additional resources from MAPS: https://maps.org/research/mdma/ptsd/phase3&https://maps.org/research/mdma/mdma-research-timelineJoin us for NeuroBeer every Monday (8pm EDT) & NeuroDrugs every Wednesday (9pm EDT) on YouTube for the largest interactive live streaming journal club & contribute to the conversation! Stay tuned to stay up to date with the latest in neuroscience / general science news! A Production of First-Person SciencePlease subscribe @ www.youtube.com/firstpersonsciencepodcast if you enjoy our content, and share it with friend and platforms that might be interested! It goes a long way in helping us stamp out misinformation in neuroscience media!  

Many medications are being tested to treat COVID-19, including brand new drugs designed specifically for COVID-19, such as vaccines, and others. But what if we already have the right tools to tackle covid? By understanding which human proteins the virus uses to enter our human cells, we can identify existing drugs to target these protein interactions, and design better ones, too. This research project created a protein interaction map to target sigma receptors using old and new drugs already on the shelf. Dr. David Gordon, Associate Professor at the University of California San Francisco joins us to speak about the recent manuscript published in the journal Nature. An international effort by a team of over 120 scientists, they developed a protein interaction map showing that the virus can bind to at least 332 human proteins to enter our cells to spread infection. The study demonstrates that 69 existing drugs (FDA approved or in pre-clinical development) harbor the structure and function needed to block COVID from infecting the cell, stop it's progression, or both. Open access article link: https://www.nature.com/articles/s41586-020-2286-9Find Dr. David Gordon twitter: @davidezragordonSARS-COV-2 cadaver article published May 13, 2020 addendum: https://www.nejm.org/doi/full/10.1056/NEJMc2011400 Find Dr. David Gordon twitter: @davidezragordon SARS-COV-2 cadaver article published May 13, 2020 addendum: https://www.nejm.org/doi/full/10.1056/NEJMc2011400  -------------------------------------------------------------------Interested in how the brain works? Frustrated by hyped up media headlines? Science paywalls obstructing your ability to fact check? We've got you covered. We're Making Neuroscience Accessible, & Bridging Gaps Between Scientists & The Public. Reviewing Neuroscience research papers ft. first-person perspectives & narratives from the scientists themselves. A platform enabling collaboration between scientists & the public, alike. Cutting through the jargon & Demolishing barriers to science communication. Our 'Journal Club' video podcast give scientists a platform to control the scientific narrative & dispel the misinformation & fake news surrounding their science. Subscribe & follow along w/ point-by-point visuals and graphs from the research paper. Support our goals of improving science communication, please like subscribe & share our videos on social media, reddit, or with anyone you think may be interested. Follow us to stay up to date on the latest research: www.youtube.com/firstpersonsciencepodcast Twitter: www.twitter.com/FirstPersonSci Instagram: www.instagram.com/firstpersonsciencepodcast/ Direct Audio Download: www.firstpersonscience.podbean.com  Want to empower those without science backgrounds & improve public scientific literacy simultaneously? Want to share your research or get involved with the show? Get in touch @ www.firstpersonscience.ca or Email us: firstpersonsciencepod@gmail.com  Produced by Roger Hudson, PhDc,Dr. Mina Nashed, PhD,Dr. Stephen Daniels, PhD,Dr. Paul Sheppard, PhD,Nicole Buchner, BSc,Music: MegaDisko by Navigator Black & the Indighost 

#reconsolidation #PTSD #neuroscience #learning #memory From NeuroBeer #4 - streamed live June 15, 2020. Full conversation: https://youtu.be/yhxyuBLiLs8 In order to remember something, you must have learned it first. When something new is learned, the brain stores that information through a series of electro-chemical connections between neurons, known as a memory 'engram'. These 'neural engrams' allow for the recall of memories by triggering the re-activation of the same brain connections where the memory was stored. Many prominent theories of learning and memory in neuroscience suggest that when a memory is recalled, it is subject to modification - the strength of the memory can be increased or decreased depending on how much attention is devoted to the memory once it's recalled. So is it better to learn the first time? Or does one need to re-learn the same information repeatedly throughout life to ensure it doesn't vanish from memory? We cover memory engrams, evolutionary biology of memory, bible history and potential applications of reconsolidation to PTSD treatment. We're a group of Canadian neuroscientists reviewing the latest news, events and scholarly publications from this week in neuroscience and beyond! In each NeuroDrugs live stream we review classics in the field of addiction neuroscience, as well as newly published articles on a weekly basis. open access articles: https://www.cell.com/neuron/fulltext/S0896-6273(20)30354-8?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0896627320303548%3Fshowall%3Dtrue & https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680680/ Additional resources: https://www.sciencedaily.com/releases/2020/06/200604152116.htm & https://www.sciencedaily.com/releases/2020/06/200605105359.htm Join us for NeuroBeer every Monday (8pm EDT) & NeuroDrugs every Wednesday (9pm EDT) on YouTube for the largest interactive live streaming journal club & contribute to the conversation! Stay tuned to stay up to date with the latest in neuroscience / general science news! A Production of First-Person SciencePlease subscribe @ www.youtube.com/firstpersonsciencepodcast if you enjoy our content, and share it with friend and platforms that might be interested! It goes a long way in helping us stamp out misinformation in neuroscience media!  

From FPS NeuroBeer Live Stream #5 - June 22, 2020Catch the full conversation here: https://youtu.be/yhxyuBLiLs8The study we review in this NeuroBeer clip investigated dose-dependent distortions in the subjective experience of one’s self - often termed coloquially as 'Ego Death'. They defined ego dissolution as 'a phenomenon characterized by the reduction in the self-referential awareness that defines normal waking consciousness, ultimately disrupting self-world boundaries and increasing feelings of unity with others’ and one’s surroundings': https://www.nature.com/articles/s41386-020-0718-8Timothy Leary once used the term to describe the first phase of an LSD trip in particular where a "complete transcendence" of the self and 'the game'occurs: http://psychedelicfrontier.com/wp-content/uploads/2014/02/The-Psychedelic-Experience-A-Manual-Based-on-the-Tibetan-Book-of-the-Dead.pdf We discuss a recently published manuscript exploring ego dissolution following psilocybin administration in a controlled setting. The authors claim this effect if mediated by glutamate in the cortex, but... well, you'll see.Join us for NeuroBeer & contribute to the conversation LIVE every Monday (8pm EDT) & Wednesday (9pm EDT) on YouTube or Twitch. Join the conversation, questions posted on the DrugNers Discord Server (NeuroBeer-Live-Chat Channel) show up on screen live: https://discord.gg/EWzbNMcA Production of First-Person SciencePlease subscribe @ www.youtube.com/firstpersonsciencepodcast if you enjoy our content, and share it with friend and platforms that might be interested! It goes a long way in helping us stamp out misinformation in neuroscience media!  

#addiction #neuroscience #memory #wanting #liking #addictedbrainFrom NeuroDrugs #2 - streamed live July 15, 2020. Full conversation: https://youtu.be/X8_fSqM7AZI How long does it take for the addicted brain to go back to normal, or when brain dopamine receptor levels take to return to baseline following addiction? As the saying goes, once an addict, always an addict, but is this true for the brain?We're a group of Canadian neuroscientists reviewing the latest news, events and scholarly publications from this week in neuroscience and beyond! In each NeuroDrugs live stream we review classics in the field of addiction neuroscience, as well as newly published articles on a weekly basis. In this clip we comment on the breakthrough neuroscience research article that began the 'wanting/liking' dichotomy that researchers are still investigating to this day. Titled "The neural basis of drug craving: An incentive-sensitization theory of addiction", Terry E. Robinson & Kent C. Berridge present a bio - psychological theory of drug addiction, the ‘Incentive-Sensitization Theory’.The theory addresses three fundamental questions. 1) why do addicts crave drugs? 2) why does drug craving persist even after long periods of abstinence? 3) Whether 'wanting' drugs (drug craving) is attributable to ‘liking’ drugs (to the subjective pleasurable effects of drugs)? Or possibly due to external components altogether. The incentive-sensitization theory of addiction posits the following.1. Addictive drugs enhance dopamine transmission in brain reward regions2. A major psychological function of this neural system is to attribute ‘incentive salience’ to the perception and mental representation of events associated with activation of the system (drug associated cues and stimuli). 3. In some individuals the repeated use of addictive drugs produces adaptations in this system, rendering it increasingly and perhaps permanently, hypersensitive (‘sensitized’) to drugs and drug-associated stimuli. This is ultimately a learning & memory based effect. open access articles: https://www.sciencedirect.com/science/article/abs/pii/016501739390013P & https://www.sciencedirect.com/science/article/pii/S2352154617301948)Join us for NeuroBeer every Monday (8pm EDT) & NeuroDrugs every Wednesday (9pm EDT) on YouTube for the largest interactive live streaming journal club & contribute to the conversation! Stay tuned to stay up to date with the latest in neuroscience / general science news! A Production of First-Person SciencePlease subscribe @ www.youtube.com/firstpersonsciencepodcast if you enjoy our content, and share it with friend and platforms that might be interested! It goes a long way in helping us stamp out misinformation in neuroscience media!   

#neuroscience #journalclub #sexdifferences It's been proposed that studying male vs female changes in brain-behaviour interactions are vital for the progression of drug development in psychiatric disorders. Indeed, these differences are abundant in neuroscience research, so much so that the NIH has mandated that all new grant proposals must measure differences between males vs females. But are these mandates really necessary? We discuss the pros vs cons of including males and females in neuroscience experiments. What is the depth of these differences? Are male vs female comparisons necessary for neuroscience to progress? Open access articles: https://www.sciencedirect.com/science/article/abs/pii/S107474272030126X& https://link.springer.com/article/10.1007/s00213-020-05542-8?utm_source=toc&utm_medium=email&utm_campaign=toc_213_237_8&utm_content=etoc_springer_20200711Additional resources: https://www.nature.com/articles/d41586-019-00677-xhttps://massivesci.com/articles/neuroscience-sex-differences-feminism-stem-brain-research/https://www.wired.com/story/a-study-finds-sex-differences-in-the-brain-does-it-matter/Join us for NeuroBeer every Monday (8pm EDT) & NeuroDrugs every Wednesday (9pm EDT) on YouTube for the largest interactive live streaming journal club & contribute to the conversation! Stay tuned to stay up to date with the latest in neuroscience / general science news! A Production of First-Person SciencePlease subscribe @ www.youtube.com/firstpersonsciencepodcast if you enjoy our content, and share it with friend and platforms that might be interested! It goes a long way in helping us stamp out misinformation in neuroscience media!  

#addiction #depression #ketamine #schizophrenia #legalize #cannabis #dopamine #neuroscience #NeuroBeer #liveWe're live tonight at 8pm to chat about recent neuroscience publications painting cannabis legalization as a gateway to increased rates of psychosis and schizophrenia. We'll also discuss whether ketamine should be treated as a final frontier of depression treatment. There is much that remains to be known about our understanding of ketamine’s antidepressant properties; and although the arrival of esketamine has been received with great enthusiasm, it is now more important than ever that its mechanisms of action be fully delineated, and both the short- and long-term neurobiological/functional consequences of its treatment be thoroughly characterized.links to articles: https://jamanetwork-com.proxy1.lib.uwo.ca/journals/jamapsychiatry/article-abstract/2763798 &https://www.sciencedirect.com/science/article/pii/S0166432819316158 We're 4 Canadian neuroscientists reviewing the latest news, events and scholarly publications from neuroscience in our weekly NeuroBeer live stream!Join us for virtual journal club-esque conversations, & contribute to the discussion with comments, suggestions, recommendations and beyond! We hold NeuroBeer every Monday (8pm EDT) & NeuroDrugs every Wednesday (9pm EDT) on YouTube. Stay tuned and subscribe for more content, and to stay up to date with the latest in neuroscience newsLeave a comment to join the conversation and guide the discussion!Interested in Neuroscience research? Frustrated by hyped up media headlines? Science paywalls obstructing your ability to fact check? We've got you covered. Our 'Journal Club' video podcast give scientists a platform to control the scientific narrative & dispel the misinformation & fake news surrounding their science.Reviewing Neuroscience research papers ft. first-person perspectives & narratives from the scientists themselves. A platform enabling collaboration between scientists & the public, alike. Cutting through the jargon & Demolishing barriers to science communication. Support our goal of improving science communication by subscribing, following & sharing our videos with your friends & social media.Subscribe on YouTube & follow along w/ point-by-point visuals and graphs from the research paper: www.youtube.com/firstpersonsciencepodcast?sub_confirmation=1Intro music by Navigator Black & The IndighostA Production of First-Person Sciencesubscribe @ www.youtube.com/firstpersonsciencepodcast  

#cannabidiol #CBD #cannabis #covid19 #elsevier #publishorperish #neuroscience #NeuroBeerLeave a comment to join the conversation and guide the discussion!Interested in Neuroscience research? Frustrated by hyped up media headlines? Science paywalls obstructing your ability to fact check? We've got you covered. Our 'Journal Club' video podcast give scientists a platform to control the scientific narrative & dispel the misinformation & fake news surrounding their science.Reviewing Neuroscience research papers ft. first-person perspectives & narratives from the scientists themselves. A platform enabling collaboration between scientists & the public, alike. Cutting through the jargon & Demolishing barriers to science communication. Support our goal of improving science communication by subscribing, following & sharing our videos with your friends & social media.Subscribe on YouTube & follow along w/ point-by-point visuals and graphs from the research paper: www.youtube.com/firstpersonsciencepodcast?sub_confirmation=1Intro music by Navigator Black & The Indighost A Production of First-Person Sciencesubscribe @ www.youtube.com/firstpersonsciencepodcast 

#cannabis #brain #neuroscience #mentalhealthWe're live at *8:30PM* tonight to discuss exciting new research on changes in brain connectivity following cannabis use: https://neurosciencenews.com/cannabis-brain-connectivity-16606/and to debate why truly novel drugs for mental health disorders haven't emerged in 50+ years. Join the DrugNerds discord server: https://discord.gg/pQBY9jj for comments to display live onscreen and to contribute to the conversation live! NeuroBeer Live Stream by the First-Person Science Crew: Monday's 8pm EDT, Wednesday's 9pm EDT---------------------------------------------------------------------------------------------------------Interested in Neuroscience research? Frustrated by hyped up media headlines? Science paywalls obstructing your ability to fact check? We've got you covered. Our 'Journal Club' video podcast give scientists a platform to control the scientific narrative & dispel the misinformation & fake news surrounding their science.Reviewing Neuroscience research papers ft. first-person perspectives & narratives from the scientists themselves. A platform enabling collaboration between scientists & the public, alike. Cutting through the jargon & Demolishing barriers to science communication. Support our goal of improving science communication by subscribing, following & sharing our videos with your friends & social media.Subscribe on YouTube & follow along w/ point-by-point visuals and graphs from the research paper: www.youtube.com/firstpersonsciencepodcast?sub_confirmation=1Intro music by Navigator Black & The Indighost A Production of First-Person Sciencesubscribe @ www.youtube.com/firstpersonsciencepodcast 

#LSD #psychosis #cannabis #addiction #psychedelics #glutamate #neuroscience #serotoninWe're Live to discuss and debate some of the latest developments that have damaged the reputations of science and scientists! Join the DrugNerds discord server: https://discord.gg/pQBY9jj for comments to display live onscreen and to contribute to the conversation live! NeuroBeer Live Stream by the First-Person Science Crew: Monday's 8pm EST---------------------------------------------------------------------------------------------------------Interested in Neuroscience research? Frustrated by hyped up media headlines? Science paywalls obstructing your ability to fact check? We've got you covered. Our 'Journal Club' video podcast give scientists a platform to control the scientific narrative & dispel the misinformation & fake news surrounding their science.Reviewing Neuroscience research papers ft. first-person perspectives & narratives from the scientists themselves. A platform enabling collaboration between scientists & the public, alike. Cutting through the jargon & Demolishing barriers to science communication. Support our goal of improving science communication by subscribing, following & sharing our videos with your friends & social media.Subscribe on YouTube & follow along w/ point-by-point visuals and graphs from the research paper: www.youtube.com/firstpersonsciencepodcast?sub_confirmation=1 A Production of First-Person Science subscribe @ www.youtube.com/firstpersonsciencepodcast 

From NeuroDrugs #2 - streamed live July 15, 2020.Catch the full conversation here: https://youtu.be/X8_fSqM7AZI We're 4 Canadian neuroscientists reviewing the latest news, events and scholarly publications from this week in neuroscience and beyond! In each NeuroDrugs stream we review classics in the field of addiction neuroscience, as well as newly published articles on a weekly basis. In this clip we review the classic publication that began the 'wanting/liking' dichotomy that researchers are still investigating to this day. Titled "The neural basis of drug craving: An incentive-sensitization theory of addiction", Terry E. Robinson & Kent C. Berridge present a bio - psychological theory of drug addiction, the ‘Incentive-Sensitization Theory’.The theory addresses three fundamental questions. 1) why do addicts crave drugs? 2) why does drug craving persist even after long periods of abstinence? 3) Whether 'wanting' drugs (drug craving) is attributable to ‘liking’ drugs (to the subjective pleasurable effects of drugs)? Or possibly due to external components altogether. The incentive-sensitization theory of addiction posits the following.1. Addictive drugs enhance dopamine transmission in brain reward regions2. A major psychological function of this neural system is to attribute ‘incentive salience’ to the perception and mental representation of events associated with activation of the system (drug associated cues and stimuli). 3. In some individuals the repeated use of addictive drugs produces adaptations in this system, rendering it increasingly and perhaps permanently, hypersensitive (‘sensitized’) to drugs and drug-associated stimuli. This is ultimately a learning & memory based effect. open access articles: https://www.sciencedirect.com/science/article/abs/pii/016501739390013P & https://www.sciencedirect.com/science/article/pii/S2352154617301948) Join us for live stream journal club style conversations & contribute to the discussion at NeuroBeer every Monday (8pm EDT) & NeuroDrugs every Wednesday (9pm EDT) on YouTube. Stay tuned and subscribe for more content, and to stay up to date with the latest in neuroscience / general science newsA Production of First-Person Sciencesubscribe @ www.youtube.com/firstpersonsciencepodcast 

#psilocybin #ego #Psychotherapy #Psychedelics #synapse #glutamate #neuroscience We're Live at 8pm EDT to discuss new research investigating how psilocybin dissolves the ego and how biology can improve artificial synapses and Artifical intelligence. NeuroBeer Live Stream by the First-Person Science Crew: Monday's 8pm EST---------------------------------------------------------------------------------------------------------Interested in Neuroscience research? Frustrated by hyped up media headlines? Science paywalls obstructing your ability to fact check? We've got you covered.Our 'Journal Club' video podcast give scientists a platform to control the scientific narrative & dispel the misinformation & fake news surrounding their science. Reviewing Neuroscience research papers ft. first-person perspectives & narratives from the scientists themselves.A platform enabling collaboration between scientists & the public, alike. Cutting through the jargon & Demolishing barriers to science communication.Support our goal of improving science communication by subscribing, following & sharing our videos with your friends & social media. Subscribe on YouTube & follow along w/ point-by-point visuals and graphs from the research paper: www.youtube.com/firstpersonsciencepodcast?sub_confirmation=1 A production of First-Person Sciencesubscribe @ www.youtube.com/firstpersonsciencepodcast   

#addiction #neuroscience #dopamine #wanting #liking #NeuroDrugs #liveWe're live tonight at 9pm to chat about individual differences in addiction! Why do some people get addicted while others don't? Why is it easier for some to quit while addicted while others struggle more? Why are some more vulnerable to craving and relapse than others? And what does learning and memory have to do with any of this?Today's paper is entitled "Individual differences in the attribution of incentive salience to reward-related cues: Implications for addiction" Open access article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2635343/ We're 4 Canadian neuroscientists reviewing the latest news, events and scholarly publications from neuroscience in our weekly NeuroBeer live stream!Join us for virtual journal club-esque conversations, & contribute to the discussion with comments, suggestions, recommendations and beyond! We hold NeuroBeer every Monday (8pm EDT) & NeuroDrugs every Wednesday (9pm EDT) on YouTube. Stay tuned and subscribe for more content, and to stay up to date with the latest in neuroscience newsLeave a comment to join the conversation and guide the discussion!Interested in Neuroscience research? Frustrated by hyped up media headlines? Science paywalls obstructing your ability to fact check? We've got you covered. Our 'Journal Club' video podcast give scientists a platform to control the scientific narrative & dispel the misinformation & fake news surrounding their science.Reviewing Neuroscience research papers ft. first-person perspectives & narratives from the scientists themselves. A platform enabling collaboration between scientists & the public, alike. Cutting through the jargon & Demolishing barriers to science communication. If you enjoy this content please consider subscribing to our YT channel www.youtube.com/firstpersonsciencepodcast - It makes a world of difference in our quest to make neuroscience accessible and correct/stop the spread of science misinformation!Join us for virtual journal club-esque conversations, & contribute to the discussion with comments, suggestions, recommendations and beyond! We hold NeuroBeer every Monday (8pm EDT) & NeuroDrugs every Wednesday (9pm EDT) on YouTube. Stay tuned and subscribe for more content, and to stay up to date with the latest in neuroscience newsIntro music by Navigator Black & The Indighost 

#addiction #opiates #memory #learning #reward #dopamine #neuroscience #NeuroBeer link to article: https://www.annualreviews.org/doi/abs/10.1146/annurev-psych-010418-103337 Leave a comment to join the conversation and guide the discussion! Interested in Neuroscience research? Frustrated by hyped up media headlines? Science paywalls obstructing your ability to fact check? We've got you covered. Our 'Journal Club' video podcast give scientists a platform to control the scientific narrative & dispel the misinformation & fake news surrounding their science. Reviewing Neuroscience research papers ft. first-person perspectives & narratives from the scientists themselves. A platform enabling collaboration between scientists & the public, alike. Cutting through the jargon & Demolishing barriers to science communication. Support our goal of improving science communication by subscribing, following & sharing our videos with your friends & social media. Subscribe on YouTube & follow along w/ point-by-point visuals and graphs from the research paper: www.youtube.com/firstpersonsciencepodcast?sub_confirmation=1 Intro music by Navigator Black & The Indighost 

#addiction #theories #neuroscience Leave a comment to join the conversation and guide the discussion! Interested in Neuroscience research? Frustrated by hyped up media headlines? Science paywalls obstructing your ability to fact check? We've got you covered. Our 'Journal Club' video podcast give scientists a platform to control the scientific narrative & dispel the misinformation & fake news surrounding their science. Reviewing Neuroscience research papers ft. first-person perspectives & narratives from the scientists themselves. A platform enabling collaboration between scientists & the public, alike. Cutting through the jargon & Demolishing barriers to science communication. Support our goal of improving science communication by subscribing, following & sharing our videos with your friends & social media. Subscribe on YouTube & follow along w/ point-by-point visuals and graphs from the research paper: www.youtube.com/firstpersonsciencepodcast?sub_confirmation=1 Intro music by Navigator Black & The Indighost 

#History #opiates #harms #benefits #neurobiology #neuroscience #addiction #science #live #livestream #askscience #medicine #addictionscience We're Live at 9pm to review the history of opiates, their potential harms & benefits of in the context of addiction and medical use, and the neuroscience of opiate addiction! Join the DrugNerds discord server: https://discord.gg/pQBY9jj for comments to display live onscreen and to contribute to the conversation live! NeuroBeer Live Stream by the First-Person Science Crew: Monday's 8pm EDT, Wednesday's 9pm EDT---------------------------------------------------------------------------------------------------------Interested in Neuroscience research? Frustrated by hyped up media headlines? Science paywalls obstructing your ability to fact check? We've got you covered. Our 'Journal Club' video podcast give scientists a platform to control the scientific narrative & dispel the misinformation & fake news surrounding their science. Reviewing Neuroscience research papers ft. first-person perspectives & narratives from the scientists themselves. A platform enabling collaboration between scientists & the public, alike. Cutting through the jargon & Demolishing barriers to science communication. Support our goal of improving science communication by subscribing, following & sharing our videos with your friends & social media. Subscribe on YouTube & follow along w/ point-by-point visuals and graphs from the research paper: www.youtube.com/firstpersonsciencepodcast?sub_confirmation=1 Intro music by Navigator Black & The Indighost 

In this video we discuss the root causes and some extreme examples of fake news in science. How can we work together to stop this ongoing trend of misinformation and anti-science activism? The Media will often use strategies of selectivity to present a narrative that is most appealing to their financial interests (cannabis causes schizophrenia? Find out tonight at 6). However, these narratives do not work to benefit the public whatsoever. In fact, these techniques conceal particular information, while amping up other info - which ultimately dissuades critical thinking and further fact checking, thus creating confusion and causing more harm than good.The structure of the information, the literacy of the consumer, and the accessibility of the material determine how the information is used, by whom, and the influence it ultimately has on a group, community, or society. However, there is perhaps a more dangerous perspective; that the way information is presented has the potential to misrepresent and distort, with important parallels and implication for engagement with research, media, and public policy in public forums, such as twitter and facebook.In some cases, if a series of google searches reveals informative (yet incomplete) summaries of evidence that misrepresent the rigor and strength of the component studies, it has the potential to change practice in a way that may be deleterious to future science, medicine, & public discussion. Special Thanks to GradCast for hosting this episode and supporting the fight again Science Misinformation!Check out the full episode on their website: www.gradcast.ca or their youtube channel: https://www.youtube.com/channel/UCQOc6TUPpSADZW7_hanKHEQ Interested in Neuroscience research? Frustrated by hyped up media headlines? Science paywalls obstructing your ability to fact check? We've got you covered. Our 'Journal Club' video podcast give scientists a platform to control the scientific narrative & dispel the misinformation & fake news surrounding their science. Reviewing Neuroscience research papers ft. first-person perspectives & narratives from the scientists themselves. A platform enabling collaboration between scientists & the public, alike. Cutting through the jargon & Demolishing barriers to science communication. Support our goal of improving science communication by subscribing, following & sharing our videos with your friends & social media. Subscribe on YouTube & follow along w/ point-by-point visuals and graphs from the research paper: www.youtube.com/firstpersonsciencepodcast?sub_confirmation=1 Catch episodes LIVE before they make it to YouTube - Ask Questions & have a neuroscientist answer it live! Hosted on Twitch: www.twitch.tv/firstpersonscience/about Follow us to stay up to date on the latest research: Twitter: www.twitter.com/FirstPersonSci Facebook: www.facebook.com/First-Person-Science-106183617589132/ Instagram: www.instagram.com/firstpersonsciencepodcast/ Direct Audio Download: www.firstpersonscience.podbean.com RSS Feed: https://feed.podbean.com/firstpersonscience/feed.xml Want to improve public scientific literacy and empower those without science backgrounds simultaneously? Want to share your research or get involved with the show? Get in touch @ www.firstpersonscience.ca or Email us: firstpersonsciencepod@gmail.com Produced by Roger Hudson, PhDcDirected by Dr. Mina Nashed, PhDVisual Effects by Dr. Stephen Daniels, PhDAudio Mixing by Dr. Paul Sheppard, PhDDigital Marketing by Bryan Jenkins, PhDcTheme music: MegaDisko by Navigator Black & the Indighost

What is the value of science communication if there is distrust in the accuracy, completeness, or truthfulness of the information presented? Media will often use strategies of selectivity to present a narrative that is most appealing to their financial interests (cannabis causes schizophrenia? Find out tonight at 6), but do not work to benefit the public whatsoever. In fact, these techniques to conceal some information, while bringing other info to light actively works against the interest of the public, and instead dissuades critical thinking and further fact checking, ultimately creating confusion and causing more harm than good. The structure of the information, the literacy of the consumer, and the accessibility of the material determine how the information is used, by whom, and the influence it ultimately has on a group, community, or society.We planned to give you Dr. Christopher Norris's work on the positive vs negative effects of cannabis intoxication (euphoria vs anxiety) and the associated biomarkers, but we got into a discussion on the problems with pop-science & science communication - from scientist communication fails, to public ignorance, to flat out fake news portrayed by media. Stay tuned for this exciting cannabis-related episode coming soon!Produced by Roger Hudson, PhDcDirected by Dr. Mina Nashed, PhDVisual Effects by Dr. Stephen Daniels, PhDAudio Mixing by Dr. Paul Sheppard, PhDDigital Marketing by Bryan Jenkins, PhDc 

Education about the health harms of tobacco have driven nicotine use down across all age groups for several decades. However, since 2016 the rate of adolescent and teenage nicotine use has nearly tripled, most commonly in the form of e-vapes (juuling). Although nicotine vapour May potentially be less harmful to overall health than tobacco smoke, a wealth of research identifies that nicotine exposure during adolescence or teenage years dramatically increases the risk for leader mental health disorders including depression and anxiety, independent of whether the individual continues to use nicotine products later into adulthood. These largely overlooked mental health consequences to later life, as well as potential negative outcomes for multiple generations on offspring of the nicotine user amount to largely unknown consequences of adolescent nicotine exposure.In this episode, Roger Hudson joins asked to speak about his recent manuscript exploring the presence of persistent mood and anxiety disorders following nicotine exposure throat adolescence, published in the Journal Addiction Biology. Manuscript Link: https://onlinelibrary.wiley.com/doi/abs/10.1111/adb.12891 Produced by Roger Hudson, PhDcDirected by Dr. Mina Nashed, PhDVisual Effects by Dr. Stephen Daniels, PhDAudio Mixing by Dr. Paul Sheppard, PhDDigital Marketing by Bryan Jenkins, PhDc

Many claims have been made regarding the relation between cannabis use and psychiatric disorders, such as schizophrenia. The idea that frequent use of potent cannabis can elicit detrimental effects on cognition, learning & memory, & executive function is generally accepted. But how does THC, the main psychoactive compound in cannabis, produce changes in brain function that ultimately manifest as symptoms like psychosis that resemble that chief features of schizophrenia? And which brain regions & connections are primarily involved in mediating these effects?In this episode, Bryan Jenkins - Neuroscience PhD Candidate from the University of Guelph - joins us to discuss how a single exposure to vaporized THC can elicit long-term changes in brain waves (oscillatory activity) such as delta, theta, & gamma waves that strikingly resemble the changes observed in patients with schizophrenia. This work has vast implications for our understanding of recreational cannabis use & cannabis use disorder, & how they relate to brain changes that underlie the onset of schizophrenia and related disorders. These results may also inform on public health regarding the increased rates of vaping seen in youth and adolescents in recent years.Manuscript: Published in the Canadian Journal of Addiction: https://journals.lww.com/cja/Abstract/2019/09000/Extended_Attenuation_of_Corticostriatal_Power_and.9.aspxProduced by Roger Hudson, PhDcDirected by Dr. Mina Nashed, PhDVisual Effects by Dr. Stephen Daniels, PhDAudio Mixing by Dr. Paul Sheppard, PhDDigital Marketing by Bryan Jenkins, PhDc 

Neuroscience Databases & mice-sized touchscreen tablets could change how we conduct science. What is big data? And how can it help us?Alzheimer's disease is a devastating, progressive disorder that causes degeneration of neurons in the brain responsible for memory. Alzheimer's disease represents the most common cause of dementia and includes continuous decline in thinking, behavioral and social skills that disrupts a person's ability to function independently. In this episode, Dr. Daniel Palmer - Neuroscience Post Doctoral Fellow from Western University - joins us to discuss how MouseBytes - a repository for neuroscience behavioural data - and various touchscreen operant tasks used with rodent models can be used to enhance drug development and ultimately increase the odds of getting worthy therapeutics to market. This work has vast implications for not only alzheimer's disease, but also Parkinson's Disease and several other psychiatric disorders.Manuscript: MouseBytes, an open-access high-throughput pipeline and database for rodent touchscreen-based cognitive assessment. Published in eLife. Open Access Article: https://elifesciences.org/articles/49630Produced by Roger Hudson, PhDcDirected by Dr. Mina Nashed, PhDVisual Effects by Dr. Stephen Daniels, PhDAudio Mixing by Dr. Paul Sheppard, PhDDigital Marketing by Bryan Jenkins, PhDc

Addictive drugs are said to often worsen memory, and anecdotal reports of drug-users with poor memory are abundant. But what if these reports are wrong? What if drugs of abuse can improve memory under particular circumstances? In this episode, Michael Wolter - Neuroscience PhD Candidate from the University of Guelph - joins us to discuss how Heroin and other drugs of abuse (including cocaine & nicotine) can enhance memory for events immediately preceding drug intake. This work has vast implications for the development of addiction, and for preventing relapse to addictive drugs. In fact, drug-linked experiences stored in the brain's long-term memory centres are believed to be largely responsible for relapse to drug seeking behaviour and drug abuse, even after long periods of successful abstinence. Manuscript: Modulation of object memory consolidation by Heroin and Heroin-conditioned stimuli: Role of opioid and noradrenergic systems. Published in the journal European Neuropsychopharmacology: https://www.ncbi.nlm.nih.gov/pubmed/32067860 Produced by Roger Hudson, PhDcDirected by Dr. Mina Nashed, PhDVisual Effects by Dr. Stephen Daniels, PhDAudio Mixing by Dr. Paul Sheppard, PhDDigital Marketing by Bryan Jenkins, PhDc

We discuss the mechanisms that regulate microglia phagocytosis (such as TRPV2 and other vanilloid receptors) - AKA eating apoptosis ready cells - and how the brain maintains healthy function in aging and after injury, such as traumatic brain injury (TBI).Because neurons get all the attention, you don't hear too much about glia. Although glia cells DO NOT carry nerve impulses (action potentials) they do have many important functions. In fact, without glia, the neurons would not work properly! Neuroscience PhD Candidates Matthew Maksoud and Viki Tellios join us to speak on their article - Nitric Oxide Upregulates microglia phagocytosis and increases transient receptor potential vanilloid type 2 channel expression on the plasma membrane - published in the journal Glia: https://onlinelibrary.wiley.com/doi/full/10.1002/glia.23685 Produced by Roger Hudson, PhDcDirected by Dr. Mina Nashed, PhDVisual Effects by Dr. Stephen Daniels, PhDAudio Mixing by Dr. Paul Sheppard, PhDDigital Marketing by Bryan Jenkins, PhDc

Endocannabinoids - cannabinoids made in the body, by the body - are a Hot Topic in Neuroscience & Beyond - with Western & integrative medicine coming to embrace the role of these important compounds, the EndoCannabinoid system is emerging as a therapeutic target for treatment of several psychiatric disorders. However, endocannabinoid system research is limited by scientists' ability to translate these groundbreaking research discoveries into clinical treatments, mostly due to a lack of understanding of how this system is involved with basic physiological processes, including stress & anxiety. In this episode, Dr. David Marcus - A recent graduate of the Neuroscience PhD Program at Vanderbilt University & 1st author of this episode's manuscript - joins us to speak about the recently published manuscript, "Endocannabinoid Signaling Collapse Mediates Stress-Induced Amygdalo-Cortical Strengthening", published in Neuron: https://www-sciencedirect-com.proxy1.lib.uwo.ca/science/article/pii/S0896627319310906 Produced by Roger Hudson, PhDcDirected by Dr. Mina Nashed, PhDVisual Effects by Dr. Stephen Daniels, PhDAudio Mixing by Dr. Paul Sheppard, PhDDigital Marketing by Bryan Jenkins, PhDc

Why do cannabinoids in cannabis cause nausea and vomiting in some people but not others? Is this limited to heavy users, Recreational users, medicinal cannabis patients? In this episode, FPS ventures into the unknown on the very under-researched area of Cannabinoid Hyperemesis Syndrome. In this episode neuroscience PhD candidate Marieka Devuono joins us to speak about her recently published manuscript that addresses these controversial concepts, entitled "Conditioned gaping produced by high dose Δ9-tetrahydracannabinol: Dysregulation of the hypothalamic endocannabinoid system", published in Neurophamacology.Produced by Roger Hudson, PhDc

The discovery of biomarkers related to depression and other psychiatric disorders have been accelerated in recent years due to emphasis on genomics and proteomics research, Precision medicine (or personalized medicine), and collaborative approaches across research labs. Using knowledge of these biomarkers, scientists are better able to identify of those with genetic predispositions, as well as improve diagnosis, treatment, and prognosis for those with depression (MDD). In this episode neuroscience PhD candidate, Stephen Daniels, joins us to speak about his recently published manuscript that addresses these controversial concepts, entitled "Reverse Translation of Major Depressive Disorder Symptoms: A Framework for the Behavioural Phenotyping of Putative Biomarkers", published in The Journal of Affective Disorders.Produced by Roger Hudson, PhDc 

The amygdala is a prominent brain region known for its involvement in learning and memory in emotional situations including during fear, anxiety, and pleasure - including its activation in the fight or flight response. However, this psychology related research has taken place almost exclusively in laboratory environments with limited ability to generalize to natural settings that rodents would be instinctually prepared to learn in.How the amygdala processes this information in more natural environments has not been explored. In Episode #3 of First-Person Science, PhD Candidate Peter Zambetti from the University of Washington speaks on his recently published manuscript in iScience. Using instinctual fear stimuli (a 3D owl) rather than the classic foot-shock, Dr. Zambetti aims to better understand innate defensive behaviors. "S*ex Differences in Foraging Rats to Naturalistic Aerial Predator Stimuli", published in iScience from CellPress [Volume 16, 28 June 2019, Pages 442-452] / DOI:10.1016/j.isci.2019.06.011. Open Access Article link: https://www.sciencedirect.com/science/article/pii/S2589004219301932Produced by Roger Hudson, PhDc

Evidence suggests that THC and CBD each act on specific receptors in the brain to cause different effects on Biomarkers, other neurotransmitter systems and molecular pathways. In fact, CBD can even prevent many of the side effects associated with potent cannabis (high THC cannabis) such as psychosis, paranoia, and in some cases can act as a treatment for those diagnosed with schizophrenia. In this episode of First-Person Science, PhD Candidate & Vanier Scholar Roger Hudson speaks about his recently published manuscript in the Journal Of Neuroscience, discussing how THC causes adverse psychiatric side-effects in some users, and the science of how cannabidiol (CBD) can counteract these side effects. "Cannabidiol (CBD) Counteracts the Psychotropic Side-Effects of Delta-9-Tetrahydrocannabinol (THC) in the Ventral Hippocampus through Bidirectional Control of ERK1–2 Phosphorylation", published in The Journal of Neuroscience [2019 Oct;39(44):8762–8777] / DOI:10.1523/JNEUROSCI.0708-19.2019. https://www.ncbi.nlm.nih.gov/pubmed/31570536Produced by Roger Hudson, PhDc 

In this inaugural release of First-Person Science, Roger Hudson speaks with Thomas Lapointe about his recently published manuscript that explores the behavioural and brain mRNA effects of combined escitalopram (an SSRI; antidepressant) and adjunct aripiprazole (5-HT1a agonist) in rats, with a specific focus on the 5-HT1a receptor. This podcast also discusses how scientists are enhancing the therapeutic efficacy of antidepressants and some of the mechanisms involved. "Effects of combined escitalopram and aripiprazole in rats: role of the 5-HT1a receptor", published in Psychopharmacology: https://link.springer.com/article/10.1007/s00213-019-05225-z Interested in Neuroscience research? Frustrated by hyped up media headlines? Science paywalls obstructing your ability to fact check? We've got you covered. Our 'Journal Club' video podcast give scientists a platform to control the scientific narrative & dispel the misinformation & fake news surrounding their science.Reviewing Neuroscience research papers ft. first-person perspectives & narratives from the scientists themselves. A platform enabling collaboration between scientists & the public, alike. Cutting through the jargon & Demolishing barriers to science communication.Support our goal of improving science communication by subscribing, following & sharing our videos with your friends & social media.Subscribe on YouTube & follow along w/ point-by-point visuals and graphs from the research paper: www.youtube.com/firstpersonsciencepodcast?sub_confirmation=1Catch episodes LIVE before they make it to YouTube - Ask Questions & have a neuroscientist answer it live! Hosted on Twitch: www.twitch.tv/firstpersonscience/aboutFollow us to stay up to date on the latest research: Twitter: www.twitter.com/FirstPersonSci Facebook: www.facebook.com/First-Person-Science-106183617589132/ Instagram: www.instagram.com/firstpersonsciencepodcast/ Direct Audio Download: www.firstpersonscience.podbean.com RSS Feed: https://feed.podbean.com/firstpersonscience/feed.xmlWant to improve public scientific literacy and empower those without science backgrounds simultaneously? Want to share your research or get involved with the show? Get in touch @ www.firstpersonscience.ca or Email us: firstpersonsciencepod@gmail.comProduced by Roger Hudson, PhDc