Podcasts about ELife

→ Help us improve our podcast! Click here to fill out this three-minute survey. Russ Ewell is the Executive Minister of the Bay Area Christian Church and author of "He's Not Who You Think He Is," exploring faith at the edge of modern life. He's also the founder of Deep Spirituality, E-Life, Digital Scribbler, and Hope Technology Group—initiatives addressing spiritual formation, inclusive technologies, and life-span inclusion. With over four decades of leadership experience he helps people discover biblical Christianity that is intellectually serious, emotionally grounding, and transformative. Earlier this year he wrote an op-ed for Fox News about how 40 years as a pastor is shaping his perspective on why so many young men in America are struggling. We'll primarily be talking about that today.    → Click here for Russ's Book: He's Not Who You Think He Is: Dropping Your Assumptions and Discovering God for Yourself → Click here to see Russ's op-ed with Fox News  

References eLife 2020;9:e55828 DOI:10.7554/eLife.55828Cell Death Discovery2024.  10, Article number: 231 Int J Mol Sci. 2017 Sep 15;18(9):1979Guerra, DJ.2026. Unpublished lecturesHunter/Lesh 1970. Box of Rainhttps://open.spotify.com/track/7x2xjJV3YAPeLQJ7u3Kjet?si=37646e5c42584619

ReferenceseLife 2020;9:e55828 DOI:10.7554/eLife.55828 Int J Mol Sci 2017 Sep 15;18(9):1979 Genes (Basel) 2021 Aug 31;12(9):1370Guerra, DJ.2026. Unpublished LecturesDylan, B. 1964. My Back Pages. Byrdshttps://open.spotify.com/track/1yexhSDARSLVvRCBU3wDAm?si=56d728e0cdcd42a4Winwood/Capaldi, 1970. Empty Pages. Traffichttps://open.spotify.com/track/4UhB17vQsTP0qM9grc4ZUi?si=636948e5ac7f457eSeger,B. 1972. Turn the Page.https://open.spotify.com/track/3P2XAL8UpPBM3nfvuEjHHE?si=47130e77f3ae4729

Today's episode is all about how childhood literally shapes the brain.Our most important experiences – from learning to read, to the growing complexity of our social lives at school, and even the video games we play – leave physical traces in how our brains get organized that shape how we see the world as adults.But how does the brain actually know what parts of our lives are actually important enough to reorganize around? How do particular experiences get under the hood to leave their mark on the developing brain?Today's guest, Stanford psychology professor Kalanit Grill-Spector, has spent her career trying to answer these questions. She's has been imaging children's brains – from infants to teenagers – to watch this reorganization unfold. Her work focuses on how our visual experience as children shapes our brains and how we see the world – what she and her team have found is not always what they expected.Learn MoreThe Vision and Perception Neuroscience Lab at Stanford Humanities and SciencesBrain's face recognition area grows much bigger as we get older (New Scientist, 2017)Neuroscientists use AI to simulate how the brain makes sense of the visual world (Wu Tsai Neurosciences Institute, 2025)Bridging nature and nurture: The brain's flexible foundation from birth (Wu Tsai Neurosciences Institute, 2025)Extensive childhood experience with Pokémon suggests eccentricity drives organization of visual cortex (Nature Human Behavior, 2019)Cortical recycling in high-level visual cortex during childhood development (Nature Human Behaviour, 2021)A unifying framework for functional organization in early and higher ventral visual cortex (Neuron, 2024)The emergence of visual category representations in infants' brains (eLife, 2024)White matter connections of human ventral temporal cortex are organized by cytoarchitecture, eccentricity and category-selectivity from birth (Nature Human Behaviour, 2025)Send us a text!Thanks for listening! If you're enjoying our show, please take a moment to give us a review on your podcast app of choice and share this episode with your friends. That's how we grow as a show and bring the stories of the frontiers of neuroscience to a wider audience.We want to hear from your neurons! Email us at at neuronspodcast@stanford.eduLearn more about the Wu Tsai Neurosciences Institute at Stanford and follow us on Twitter, Facebook, and LinkedIn. 

If you've ever watched a crab dart across a beach, you've probably noticed something strange - that they almost never walk forward. Instead, they scuttle sideways with surprising speed and agility, a movement so iconic it has practically become the defining feature of crabs themselves. Now, scientists have published in the journal eLife that they believe they know where this unusual walk came from. Researchers studying crab movement discovered that sideways walking likely evolved only once in the history of “true crabs,” a group known scientifically as Brachyura. That's remarkable because in evolution, useful traits often appear independently many times. Wings evolved separately in birds, bats, and insects. Streamlined body shapes evolved in dolphins and sharks despite them not being closely related. But sideways walking? Scientists think crabs only invented it once, and then stuck with it. The researchers studied how 50 different crab species moved, filming them individually in specially designed arenas that mimicked their natural environments. When they mapped those movements onto the crab family tree, a striking pattern appeared - most modern crabs inherited their sideways movement from one ancient ancestor. At first glance, walking sideways seems awkward. But for crabs, it may actually be a survival superpower. Crabs have wide, flattened bodies with legs that naturally extend outward. Moving sideways allows them to move faster and more efficiently without constantly twisting their bodies. A sideways-moving crab can rapidly dart left or right in unpredictable bursts, making it harder for predators to anticipate where it will go next. Today there are nearly 8,000 known species of true crabs living in environments ranging from deep oceans to rivers, forests, and even land. The scientists believe this evolutionary shift happened shortly after one of Earth's major extinction events: the Triassic–Jurassic extinction around 200 million years ago. At that time, the world was changing dramatically and nature was opening up entirely new ecological opportunities. Crabs may have arrived with the perfect new adaptation at exactly the right moment. Scientists often talk about “carcinization” the repeated evolution of crab-like body shapes across different crustacean groups. Oddly enough, becoming crab-shaped has happened multiple times in evolutionary history. But sideways walking appears to have been much rarer. That suggests some behaviours are surprisingly difficult to evolve, even if they turn out to be highly successful once they appear. It's easy to dismiss a crab's sideways scuttle as just a quirky detail of nature. But this study suggests it may have been one of the most important movement innovations in marine evolution. A single change in how an animal moved may have helped crabs spread across the planet, adapt to countless environments, and become one of the most successful groups of crustaceans on Earth. LISTEN ABOVESee omnystudio.com/listener for privacy information.

If you enjoy this episode, we're sure you will enjoy more content like this on The Occult Rejects.  In fact, we have curated playlists on occult topics like grimoires, esoteric concepts and phenomena, occult history, analyzing true crime and cults with an occult lens, Para politics, and occultism in music. Whether you enjoy consuming your content visually or via audio, we've got you covered - and it will always be provided free of charge.  So, if you enjoy what we do and want to support our work of providing accessible, free content on various platforms, please consider making a donation to the links provided below.  Thank you and enjoy the episode!Links For The Occult Rejectshttps://linktr.ee/theoccultrejectsOccult Research Institutehttps://www.occultresearchinstitute.org/Cash Apphttps://cash.app/$theoccultrejectsVenmo@TheOccultRejectsBuy Me A Coffeebuymeacoffee.com/TheOccultRejectsPatreonhttps://www.patreon.com/TheOccultRejectsFull show-notes bibliographyCore EEG and oscillationsAbubaker, M., & Dankaerts, W. (2021). Working memory and cross-frequency coupling of neuronal oscillations. *Frontiers in Psychology, 12*, 742860.Axmacher, N., Henseler, M. M., Jensen, O., Weinreich, I., Elger, C. E., & Fell, J. (2010). Cross-frequency coupling supports multi-item working memory in the human hippocampus. *Proceedings of the National Academy of Sciences, 107*(7), 3228–3233.Jensen, O., & Mazaheri, A. (2010). Shaping functional architecture by oscillatory alpha activity: Gating by inhibition. *Frontiers in Human Neuroscience, 4*, 186.Rayi, A., et al. (2022). Electroencephalogram. *StatPearls*. StatPearls Publishing.StatPearls / NCBI Bookshelf. (2024). Introduction to electroencephalography (EEG). *NCBI Bookshelf*.Theta, alpha, beta, gamma, and controlCavanagh, J. F., & Shackman, A. J. (2015). Frontal midline theta reflects anxiety and cognitive control: Meta-analytic evidence. *Journal of Physiology-Paris, 109*(1–3), 3–15.Eisma, J., et al. (2021). Frontal midline theta differentiates separate cognitive control strategies while still generalizing the need for cognitive control. *Scientific Reports, 11*, 14641.Jensen, O., Bonnefond, M., & VanRullen, R. (2012). An oscillatory mechanism for prioritizing salient unattended stimuli. *Trends in Cognitive Sciences, 16*(4), 200–206.Lundqvist, M., Herman, P., & Miller, E. K. (2018). Working memory: Delay activity, yes! Persistent activity? Maybe not. *Journal of Neuroscience, 38*(32), 7013–7019.Sleep architecture, spindles, and memoryCaporro, M., Haneef, Z., Yeh, H.-J., Mohamed, F. B., & Levin, H. S. (2012). Functional MRI of sleep spindles and K-complexes. *Clinical Neurophysiology, 123*(2), 303–309.Chen, P., Miao, X., Chen, J., et al. (2023). The devastating effects of sleep deprivation on memory: Lessons from rodent models, aging, and Alzheimer's disease. *Frontiers in Neuroscience, 17*, 1151639.Ng, T., et al. (2025). Bayesian meta-analysis reveals the mechanistic role of slow oscillation-spindle coupling in sleep-dependent memory consolidation. *eLife, 13*, RP101992.Patel, A. K., et al. (2024). Physiology, sleep stages. *StatPearls*. StatPearls Publishing.Páez, A., Gillman, S. O., Dogaheh, S. B., et al. (2025). Sleep spindles and slow oscillations predict cognition and biomarkers of neurodegeneration in mild to moderate Alzheimer's disease. *Alzheimer's & Dementia, 21*, e14424.Hypnagogia, N1, and dream incubationHorowitz, A. H., Esfahany, S., Boyle, M. R., et al. (2023). Targeted dream incubation at sleep onset increases post-sleep creative performance. *Scientific Reports, 13*, 5055.Lacaux, C., Andrillon, T., Bastoul, D., et al. (2021). Sleep onset is a creative sweet spot. *Science Advances, 7*(50), eabj5866.Meditation, prayer, chanting, and yoga nidraDatta, K., Mallick, H. N., Tripathi, M., Ahuja, G. K., & Deepak, K. K. (2022). Electrophysiological evidence of local sleep during yoga nidra practice in young male volunteers. *Frontiers in Neurology, 13*, 910794.Dobrakowski, P., Błaszkiewicz, M., & Skalski, S. (2020). Changes in the electrical activity of the brain in the alpha and theta bands during prayer and meditation. *International Journal of Environmental Research and Public Health, 17*(24), 9567.Gao, J., Leung, H. K., Wu, B. W. Y., Skouras, S., & Sik, H. H. (2019). The neurophysiological correlates of religious chanting. *Scientific Reports, 9*, 4262.Kaur, C., & Singh, P. (2015). EEG derived neuronal dynamics during meditation: Progress and challenges. *Advances in Preventive Medicine, 2015*, 614723.Lomas, T., Ivtzan, I., & Fu, C. H. Y. (2015). A systematic review of the neurophysiology of mindfulness on EEG oscillations. *Neuroscience & Biobehavioral Reviews, 57*, 401–410.Hypnosis and suggestionJensen, M. P., Adachi, T., & Hakimian, S. (2015). Brain oscillations, hypnosis, and hypnotizability. *American Journal of Clinical Hypnosis, 57*(3), 230–253.Kirenskaya, A. V., Novototsky-Vlasov, V. Y., Chistyakov, A. V., & Zvonikov, V. M. (2011). Waking EEG spectral power and coherence differences between highly hypnotizable and low hypnotizable subjects. *International Journal of Clinical and Experimental Hypnosis, 59*(2), 144–164.Mendoza, M. E., & Capafons, A. (2024). Neural correlates of hypnosis: A systematic narrative review. *Frontiers in Psychology, 15*, 1327738.Ritual rhythm, trance, and synchronyHuels, E. R., Kim, H. S., Lee, U., & Mollaahmetoglu, O. M. (2021). Neural correlates of the shamanic state of consciousness. *Frontiers in Human Neuroscience, 15*, 610466.Mogan, R., Fischer, R., & Bulbulia, J. A. (2017). To be in synchrony or not? A meta-analysis of synchrony's effects on behavior, perception, cognition and affect. *Journal of Experimental Social Psychology, 72*, 13–20.Tarr, B., Launay, J., & Dunbar, R. I. M. (2016). Silent disco: Dancing in synchrony leads to elevated pain thresholds and social closeness. *Evolution and Human Behavior, 37*(5), 343–349.Entrainment, binaural beats, fatigue, and overloadGoodman, S. P. J., et al. (2025). Approaches to inducing mental fatigue: A systematic review and meta-analysis of (neuro)physiologic indices. *Neuroscience & Biobehavioral Reviews, 170*, 105957.Ingendoh, R. M., Posny, E. S., & Heine, A. (2023). Binaural beats to entrain the brain? A systematic review of the effects of binaural beat stimulation on brain oscillatory activity, and the implications for psychological research and intervention. *PLOS ONE, 18*(5), e0286023.Snipes, S., et al. (2024). Extended wakefulness alters the relationship between EEG theta and alpha bursts and behavioural outcome. *European Journal of Neuroscience, 60*(8), 6268–6284.Xiang, C., et al. (2024). A resting-state EEG dataset for sleep deprivation. *Scientific Data, 11*, 406.Parkinson's disease and pathological betaAsadi, A., et al. (2022). The origin of abnormal beta oscillations in the parkinsonian corticobasal ganglia circuit. *Frontiers in Neuroscience, 16*, 823719.Paulo, D. L., et al. (2023). Corticostriatal beta oscillation changes associated with cognitive function in Parkinson's disease. *NPJ Parkinson's Disease, 9*, 202.Ancient sleep, dreams, and Asclepian healingAskitopoulou, H. (2015). Sleep and dreams: From myth to medicine in ancient Greece. *Journal of Anesthesia History, 1*(3), 70–75.Kapotsis, G., & Steiropoulos, P. (2025). Sleep incubation [enkoimesis] in medical practice at Asclepieia of Ancient Greece — the Ancient Greek sleep medicine. *Sleep Medicine, 130*, 85–89.Pavli, A. (2024). Asclepieia in ancient Greece: pilgrimage and healing. *Journal of Integrative Medicine and Research, 3*(2), 100119.Also want to remind people about the website, if you're into reading we have tons of information by multiple contributors, and we got t-shirts up on the site if you're interested. Fun fact, the art is all based on the eyeball. A

Is the DMT laser experiment proof we are in a simulation? Strangers see the same alien glyphs, the code of reality. Neuroscience explains it. Almost...Is the "Code of Reality" a genuine window into a computed simulation, or merely an artifact of our brain's architecture?I deep dive into the DMT laser experiment, a $15 protocol that allegedly reveals hidden source code of our universe. I investigate why strangers independently report the same bizarre characters and geometric structures, and whether this "shared reality" unveils the Matrix or is simply a trick of our visual cortex.Topics (among others):The Code of Reality: How Danny Goler's repeatable experiment uses a 650nm red laser and DMT to induce perceptions of a high-definition hyper-structure of code.The 40,000-Year Trail: Why Paleolithic cave art, UFO glyphs, and Soviet Kozyrev Mirror experiments all feature similar geometric codes/glyphs long before the modern simulation hypothesis interpretations.Neuroscience vs. Simulation: How the Bressloff-Cowan V1 Model provides a mathematical model for why our natural brain wiring produces similar "form constants" with hallucinogens.Consider Supporting + Receive Bonus Content⁠

If you enjoy this episode, we're sure you will enjoy more content like this on The Occult Rejects.  In fact, we have curated playlists on occult topics like grimoires, esoteric concepts and phenomena, occult history, analyzing true crime and cults with an occult lens, Para politics, and occultism in music. Whether you enjoy consuming your content visually or via audio, we've got you covered - and it will always be provided free of charge.  So, if you enjoy what we do and want to support our work of providing accessible, free content on various platforms, please consider making a donation to the links provided below.  Thank you and enjoy the episode!Links For The Occult Rejectshttps://linktr.ee/theoccultrejectsOccult Research Institutehttps://www.occultresearchinstitute.org/Cash Apphttps://cash.app/$theoccultrejectsVenmo@TheOccultRejectsBuy Me A Coffeebuymeacoffee.com/TheOccultRejectsPatreonhttps://www.patreon.com/TheOccultRejectsPrimary / traditional texts and core religious sourcesĀnāpānasati Sutta (MN 118), translated by Thanissaro Bhikkhu, Access to Insight. Best primary source for Buddhist mindfulness of breathing.“Ḏekr / Dhikr,” Encyclopaedia Iranica. Strong source for Sufi remembrance, rhythmic repetition, posture, and breathing-linked practice.“Hesychasm,” Encyclopaedia Britannica. Good general source for the Christian contemplative tradition of stillness, uninterrupted prayer, and the Jesus Prayer.“Saint Gregory Palamas,” Encyclopaedia Britannica. Useful for the role of bodily posture and controlled breathing in Hesychast prayer.Crowley, Aleister. Liber E vel Exercitiorum. Primary text for Crowley's explicit inclusion of “Pranayama – Regularisation of the Breathing” in occult training.Crowley, Aleister. Book Four, Part 1. Useful for Crowley's statement that pranayama is useful in “quieting the emotions and appetites.”Historical / religious context“Prana,” Encyclopaedia Britannica. Best short source for the deep Indian background: prāṇa, the five prāṇas, and breath as vital force.“Pranayama,” Encyclopaedia Britannica. Best short source for classical Yoga: pranayama as the fourth limb aimed toward samādhi.“Hatha Yoga,” Encyclopaedia Britannica. Useful for the force-oriented turn: bodily mastery, purification, and regulation of breathing.“Qi,” Encyclopaedia Britannica. Good for Daoist and Chinese background: qi as psychophysical energy and breath-linked vital force.“Qigong,” Encyclopaedia Britannica. Useful for qigong as a discipline combining movement, breathing, and mental concentration.“Are Kabbalistic Meditations all about Ecstasy?” in Hermes Explains (Cambridge). Strong academic source for Abraham Abulafia and ecstatic Kabbalah.“Classical Kabbalah, Its History and Symbolic Universe.” Useful academic source noting ecstatic Kabbalah's breathing exercises, postures, and developed techniques.Neuroscience / physiology / altered statesAshhad, Kam, Del Negro, and Feldman. “Breathing Rhythm and Pattern and Their Influence on Emotion.” Annual Review of Neuroscience (2022). One of the best overview papers for the whole episode.Yackle et al. “Breathing control center neurons that promote arousal in mice.” Science (2017). Key source for the preBötzinger complex / calm-vs-arousal section.Schottelkotte and Dutschmann. “Forebrain control of breathing: Anatomy and potential functions.” Frontiers in Neurology (2022). Best source for cortex, amygdala, hippocampus, hypothalamus, and thalamus in breathing control.Krohn et al. “The integrated brain network that controls respiration.” eLife (2023). Strong review for respiration as part of a larger integrated brain network.Heck et al. “Breathing as a fundamental rhythm of brain function.” Human MEG work on respiration-modulated brain oscillations across frequency bands and brain regions.(Note: the specific MEG paper surfaced in earlier research as the respiration-modulated oscillations study; the review sources above are the strongest anchors for that section.)Zelano et al. “Nasal Respiration Entrains Human Limbic Oscillations and Modulates Cognitive Function.” Journal of Neuroscience (2016). One of the most important human papers in the whole script.Schreiner et al. “Respiration modulates sleep oscillations and memory reactivation in humans.” Nature Communications (2023). Best source for the sleep-spindle / memory-reactivation section.Zaccaro et al. “How Breath-Control Can Change Your Life: A Systematic Review on Psychophysiological Correlates of Slow Breathing.” Frontiers in Human Neuroscience / PMC version (2018). Best broad source for slow breathing under 10 breaths per minute.Shao, Man, and Lee. “The Effect of Slow-Paced Breathing on Cardiovascular and Emotion Functions: A Meta-Analysis and Systematic Review.” Mindfulness (2024). Useful for the stabilizing-road section.Kozhevnikov et al. “Neurocognitive and Somatic Components of Temperature Increases during g-Tummo Meditation.” PLoS ONE (2013). Best source for vase breathing and inner-heat claims.Zhang et al. “Hyperventilation in neurological patients: from physiology to outcome evidence.” Useful source for hypocapnia, cerebral vasoconstriction, and reduced cerebral blood flow.Havenith et al. “Decreased CO2 saturation during circular breathwork supports emergence of altered states of consciousness.” Communications Psychology (2025). The key modern paper for circular breathwork and altered-state onset. Also want to remind people about the website, if you're into reading we have tons of information by multiple contributors, and we got t-shirts up on the site if you're interested. Fun fact, the art is all based on the eyeball. Now let me introduce the rest of the panel and guests.

If you enjoy this episode, we're sure you will enjoy more content like this on The Occult Rejects.  In fact, we have curated playlists on occult topics like grimoires, esoteric concepts and phenomena, occult history, analyzing true crime and cults with an occult lens, Para politics, and occultism in music. Whether you enjoy consuming your content visually or via audio, we've got you covered - and it will always be provided free of charge.  So, if you enjoy what we do and want to support our work of providing accessible, free content on various platforms, please consider making a donation to the links provided below.  Thank you and enjoy the episode!Links For The Occult Rejectshttps://linktr.ee/theoccultrejectsOccult Research Institutehttps://www.occultresearchinstitute.org/Cash Apphttps://cash.app/$theoccultrejectsVenmo@TheOccultRejectsBuy Me A Coffeebuymeacoffee.com/TheOccultRejectsPatreonhttps://www.patreon.com/TheOccultRejects1. Patel, A. K., et al. *Physiology, Sleep Stages*. StatPearls / NCBI Bookshelf, 2024.2. Jensen, O., & Mazaheri, A. “Shaping Functional Architecture by Oscillatory Alpha Activity: Gating by Inhibition.” *Frontiers in Human Neuroscience*, 2010.3. Cavanagh, J. F., & Shackman, A. J. “Frontal Midline Theta Reflects Anxiety and Cognitive Control: Meta-Analytic Evidence.” *Journal of Physiology-Paris*, 2015.4. Axmacher, N., et al. “Cross-Frequency Coupling Supports Multi-Item Working Memory in the Human Hippocampus.” *PNAS*, 2010.5. Lacaux, C., et al. “Sleep Onset Is a Creative Sweet Spot.” *Science Advances*, 2021.6. Horowitz, A. H., et al. “Targeted Dream Incubation at Sleep Onset Increases Post-Sleep Creative Performance.” *Scientific Reports*, 2023.7. Caporro, M., et al. “Functional MRI of Sleep Spindles and K-Complexes.” *Clinical Neurophysiology*, 2012.8. Ng, T., et al. “Bayesian Meta-Analysis Reveals the Mechanistic Role of Slow Oscillation-Spindle Coupling in Sleep-Dependent Memory Consolidation.” *eLife*, 2025.9. Datta, K., et al. “Electrophysiological Evidence of Local Sleep During Yoga Nidra Practice in Young Male Volunteers.” *Frontiers in Neurology*, 2022.10. Jensen, M. P., et al. “Brain Oscillations, Hypnosis, and Hypnotizability.” *American Journal of Clinical Hypnosis*, 2015.11. Huels, E. R., et al. “Neural Correlates of the Shamanic State of Consciousness.” *Frontiers in Human Neuroscience*, 2021.12. Ingendoh, R. M., et al. “Binaural Beats to Entrain the Brain? A Systematic Review...” *PLOS ONE*, 2023.13. Páez, A., et al. “Sleep Spindles and Slow Oscillations Predict Cognition and Biomarkers of Neurodegeneration in Mild to Moderate Alzheimer's Disease.” *Alzheimer's & Dementia*, 2025.14. Askitopoulou, H. “Sleep and Dreams: From Myth to Medicine in Ancient Greece.” *Journal of Anesthesia History*, 2015.15. Pavli, A. “Asclepieia in Ancient Greece: Pilgrimage and Healing.” *Journal of Integrative Medicine and Research*, 2024.Also want to remind people about the website, if you're into reading we have tons of information by multiple contributors, and we got t-shirts up on the site if you're interested. Fun fact, the art is all based on the eyeball. Now let me introduce the rest of the panel and guests.

Никита Поваров, principal analyst в JetBrains, пришёл, чтобы рассказать об одной из самых коварных ловушек в работе с данными: мы привыкли видеть корреляции, но совершенно не умеем доказывать причинность. А разница между "связано" и "вызывает" – это разница между правильным решением и красивой иллюзией. В выпуске прошли по истории вопроса от Гальтона и Фишера до современных каузальных графов: почему исторически статистика и каузальность шли разными путями и как они всё-таки сошлись. Разбираем d-сепарацию, конфаундеры, медиаторы и строим каузальные графы на конкретных примерах из A/B тестирования, медицины и продуктовой аналитики. Выпуск для всех, кто работает с данными и хочет не просто находить паттерны, а понимать, что на что влияет и уметь это обосновать. Также ждем вас, ваши лайки, репосты и комменты в мессенджерах и соцсетях!
 Telegram-чат: https://t.me/podlodka Telegram-канал: https://t.me/podlodkanews Страница в Facebook: www.facebook.com/podlodkacast/ Twitter-аккаунт: https://twitter.com/PodcastPodlodka Ведущие в выпуске: Стас Цыганов, Егор Толстой Полезные ссылки: Фундамент — вероятность как логика E.T. Jaynes — «Probability Theory: The Logic of Science» Вес и физическая активность — каузальные модели Mendelian randomization, eLife 2022: «Mendelian randomization suggests a bidirectional, causal relationship between physical inactivity and adiposity» https://pmc.ncbi.nlm.nih.gov/articles/PMC8975550/ Multivariable MR, Nature Comms Med 2023: «Distilling causality between physical activity traits and obesity via Mendelian randomization» https://www.nature.com/articles/s43856-023-00407-5 E. Yudkowsky — «Causal Diagrams and Causal Models» https://www.lesswrong.com/posts/hzuSDMx7pd2uxFc5w/causal-diagrams-and-causal-models Выдуманный пример вес/активность/сидение-на-Reddit, как иллюстрация коллайдера Herman Pontzer — «Constrained Total Energy Expenditure and Metabolic Adaptation to Physical Activity in Adult Humans» https://pmc.ncbi.nlm.nih.gov/articles/PMC4803033/ Исторические байки Ф. Гальтон — Регрессия к среднему — Regression towards Mediocrity in Hereditary Stature, Journal of the Anthropological Institute https://galton.org/essays/1880-1889/galton-1886-jaigi-regression-stature.pdf К. Пирсон — Корреляция наше всё — «The Grammar of Science» https://archive.org/details/grammarofscience00pearrich/page/44/mode/2up Р. Фишер — ген курильщика — «Cancer and smoking», Nature https://www.nature.com/articles/182596a0 Ignaz Semmelweis — мытьё рук https://en.wikipedia.org/wiki/Ignaz_Semmelweis краткая биография https://pmc.ncbi.nlm.nih.gov/articles/PMC11568873/ Джон Сноу — холера в Лондоне https://pmc.ncbi.nlm.nih.gov/articles/PMC7150208/ Barbara Stoddard Burks — забытый пионер медиации https://danamackenzie.com/barbara-stoddard-burks-pioneer-in-causality/ Бедность и когнитивные функции https://pubmed.ncbi.nlm.nih.gov/23990553/ Дискриминация женщин — слепые прослушивания https://www.aeaweb.org/articles?id=10.1257/aer.90.4.715 Курьёз — ретроспективный эффект молитвы — «Effects of remote, retroactive intercessory prayer on outcomes in patients with bloodstream infection: randomised controlled trial» https://pubmed.ncbi.nlm.nih.gov/11751349/

Check #VZD11InBeeld op Instagram en Facebook!In VZD 11 focussen we op misschien wel de meest enigmatische groep theropoden: de spinosauriërs. Uiteraard met speciale aandacht voor de spiksplinternieuwe soort Spinosaurus mirabilis.Maar eerst geven we antwoord op drie luisteraarsvragen. En ook de winnaar van het door ons gesigneerde exemplaar van het cult-paleoart-boek “All Yesterdays” (2012) is bekend!Opgenomen op 26 maart 2026.Hoofdstukken:00:00:00 – Intro00:00:55 – Wie wint het boek “All Yesterdays” (2012)?00:03:02 – Barts 1e vraag: Status halswervel BYU 9024?00:14:43 – Barts 2e vraag: Gastralia in Ornithischia?00:21:59 – Barts 3e vraag: Evolutie sauropodentanden vs. bloemen?00:32:16 – De spinosauriërs00:33:51 – Spinosaurus aegyptiacus00:53:01 – Spinosaurus mirabilis00:59:51 – Baryonyx & Suchomimus01:05:10 – Oorsprong, verspreiding & tanden01:10:16 – Ichthyovenator & Irritator01:16:15 – Paleoart door Mark Witton01:17:30 – Paleoart door Hodari Nundu01:18:31 – Spinosauriërs in België?01:20:29 – OutroBronnen:● Taylor & Wedel 2016: “How Big Did Barosaurus Get?” (foto's!) https://www.miketaylor.org.uk/dino/pubs/svpca2016/TaylorWedel2016-how-big-did-barosaurus-get.pdf● Taylor & Wedel manuscript-in-progress: Halswervel BYU 9024 = Barosaurus https://github.com/MikeTaylor/palaeo-superbaro ● Lovelace, Hartman & Wahl 2007: Halswervel BYU 9024 = Supersaurus https://tinyurl.com/BYU9024-Barosaurus● Radermacher, Choiniere et al. 2021: Ademhaling bij Heterodontosaurus https://doi.org/10.7554/eLife.66036● Farmer 2015: Ademhaling bij krokodilachtigen https://doi.org/10.1152/physiol.00056.2014● D'Emic et al. 2013: Tandvervanging bij sauropoden https://doi.org/10.1371/journal.pone.0069235● Wu, You & Li 2017: Eerste grassen https://doi.org/10.1093/nsr/nwx145● Stromer 1915: Spinosaurus aegyptiacus https://www.biodiversitylibrary.org/item/124817#page/7/mode/1up● Ibrahim et al. 2014: Spinosaurus zwom https://doi.org/10.1126/science.1258750 ● Ibrahim et al. 2020: Spinosaurus-staart https://doi.org/10.1038/s41586-020-2190-3 ● Hone & Holtz 2021: Spinosaurus was oeverjager https://doi.org/10.26879/1110 ● Sereno et al. 2026: Spinosaurus mirabilis https://doi.org/10.1126%2Fscience.adx5486● Hendrickx, Koen Stein et al. 2024: Theropode-tanden uit de Marokkaanse Kem Kem https://doi.org/10.1080/02724634.2024.2311791● Charig & Milner 1986: Baryonyx https://doi.org/10.1038/324359a0● Samathi, Sander & Chanthasit 2021: “Phuwiang spinosaurid B” https://doi.org/10.1080/08912963.2021.1874372 ● Allain et al. 2012: Ichthyovenator https://doi.org/10.1007/s00114-012-0911-7● Schade et al. 2023: Openklappende onderkaak bij Irritator https://doi.org/10.26879/1242#VogelsZijnDinos #KoenStein #AlexanderDecommere #AllYesterdays #DarrenNaish #Supersaurus #Barosaurus #BYU9024 #Diplodocoidea #MorrisonFormatie #Heterodontosaurus #Gastralia #Ornithischia #Saurischia #Aves #Mammalia #Crocodylia #ViktorRadermacher #Titanosauria #Angiospermae #Ouranosaurus #ErnstStromer #Spinosaurus #BombardementMünchen1944 #Paralititan #TheLostDinosaursOfEgypt #WilliamNothdurft #NizarIbrahim #TheDinosaurs2026 #Nyctosaurus #Tapejara #Pterosauria #PaulSereno #KemKemFormatie #Theropoda #Baryonyx #MathiasDecommere #ArtroPoda #PhuwiangSpinosauridB #Irritator #PaleoArt #MarkWitton #HodariNundu #SpinosauridaeVragen of suggesties → ⁠vogelszijndinos@gmail.comHomepage: ⁠⁠https://vogelszijndinos.weebly.comFacebook: ⁠https://www.facebook.com/VogelszijndinosInstagram: ⁠https://www.instagram.com/vogelszijndinosHomepage Koen: ⁠⁠https://www.koenstein.commHomepage Alexander: ⁠⁠https://alexanderdecommere.weebly.comCredits:Gastheer — Filmmaker en dino-nerd Alexander DecommereGast — Paleontoloog dr. Koen SteinProductie en postproductie — Alexander DecommereMuziek — Kostas Panagiotou, van Pantheïst: ⁠https://pantheist.co.ukVZD-logo — Anke De PotterVogels zijn dino's © Alexander Decommere & Koen Stein

"We inhibited a brain region and connectivity went up. I thought it was an artifact..."Dr. Alessandro Gozzi is a systems neuroscientist investigating how the brain functions as an integrated network and how disruptions in that network relate to behavior and mental health. He is Senior Scientist and Group Leader of the Functional Neuroimaging Laboratory at the Italian Institute of Technology in Rovereto, Italy. His research combines fMRI, functional ultrasound imaging, optogenetics, chemogenetics, electrophysiology, and computational modeling to decode the neural underpinnings of brain connectivity in rodent models, with the goal of bridging circuit-level findings to human psychopathology.In this conversation, Dr. Gozzi unpacks what resting-state fMRI connectivity actually reflects and why the answer may be more surprising than the field assumes. Drawing on a series of elegant chemogenetic and pharmacological manipulations in mice, he reveals how regional excitability, rather than direct synaptic communication, may be a dominant driver of the connectivity patterns we observe. Within this context, the conversation explores the paradoxical relationship between neural silencing and hyperconnectivity, the evolutionary conservation of brain networks across species, and what rodent models of autism can and cannot tell us about human psychiatric disorders. Join the conversation to discover how mechanistic animal studies are reshaping our understanding of human brain connectivity.We hope you enjoy this episode!Chapters:00:00 - Introduction to Dr. Alessandro Gozzi05:12 - Gozzi's Unconventional Journey into Neuroscience13:17 - Transitioning from Industry to Academia20:49 - The Relevance of Rodent Models in Understanding Autism32:04 - Exploring the Complexities of Brain Connectivity38:57 - Excitability and Its Role in Connectivity Patterns42:27 - Exploring fMRI Connectivity and Local Computation45:28 - The Role of the Hearst Index in Brain Activity54:00 - Implications for Treatment in Psychiatric Disorders58:42 - The Intersection of Biology and Neuroscience Research01:07:08 - Balancing Life and Science: Personal ReflectionsWorks mentioned:00:12:48 - Gutierrez-Barragan, D. et al. (2024). Evolutionarily conserved fMRI network dynamics in the mouse, macaque, and human brain. https://doi.org/10.1038/s41467-024-49245-600:17:40 - Zerbi, V., Pagani, M. et al. (2021). Brain mapping across 16 autism mouse models reveals a spectrum of functional connectivity subtypes. https://doi.org/10.1038/s41380-021-01245-400:18:00 - Pagani, M. et al. (2021). mTOR-related synaptic pathology causes autism spectrum disorder-associated functional hyperconnectivity. https://doi.org/10.1038/s41467-021-26520-800:29:50 - Pagani, M. et al. (2025). Biological subtyping of autism via cross-species fMRI. https://doi.org/10.1101/2025.03.04.64140000:40:40 - Rocchi, F. et al. (2022). Increased fMRI connectivity upon chemogenetic inhibition of the mouse prefrontal cortex. https://doi.org/10.1038/s41467-022-28591-300:43:30 - Trakoshis, S., Martínez-Cañada, P. et al. (2020). Intrinsic excitation-inhibition imbalance affects medial prefrontal cortex differently in autistic men versus women. https://doi.org/10.7554/eLife.5568400:45:10 - Newbold, D.J. et al. (2020). Plasticity and spontaneous activity pulses in disused human brain circuits. https://doi.org/10.1016/j.neuron.2020.05.007Episode producer:Xuqian Michelle Li

“Shortening scientific loops accelerates discovery”Dr. Satrajit Ghosh is a senior research scientist at the McGovern Institute for Brain Research at MIT and an assistant professor at Harvard Medical School. He has helped advance neuroinformatics, open science, and reproducible neuroimaging through both his research and the development of widely used community tools. His work spans machine learning for neuroimaging, the neural mechanisms of speech, and the use of speech features to inform psychiatric diagnosis and treatment. He earned his bachelor's degree with honors in computer science from the National University of Singapore and his PhD in cognitive and neural systems from Boston University. He has contributed to influential projects including Nipype, fMRIPrep, and NeuroVault. More recently, he has focused on how shared scientific infrastructure can connect domains, modalities, and scales across neuroscience and help address the field's growing fragmentation.In this episode, Peter and Satrajit discuss the origins of tools like Nipype and the broader push for reproducible neuroimaging, showing how practical research challenges can inspire infrastructure that benefits the entire field. They also explore functional gradients in the brain and cerebellum, the promise of speech as a scalable biomarker for mental health, and the cautious role AI may play in diagnosis and scientific discovery. A major theme in their conversation is the fragmentation in neuroscience, with knowledge often siloed across methods, scales, and communities. Ghosh argues for a more intelligent scientific infrastructure that connects data, tools, theory, and expertise. He closes with advice to young scientists: experiment often, make mistakes, and learn by discovering where systems fail.We hope you enjoy this episode!Chapters00:00 Introduction to Satra Ghosh and His Work06:46 The Intersection of Control Theory and Speech11:18 Satra's Academic Journey into Neuroscience20:58 Neuroinformatics and Tool Development34:42 Individual Differences in Brain Structure39:21 Developing tools to augment Experimental Design44:25 Building an Intelligent Infrastructure for Neuroscience58:45 The Role of Theory in Neuroscience01:00:26 Access to Scientific Research Expediting Progress01:06:40 Experience Inherent to Learning 01:09:33 Mapping the Brain's Functional Gradient01:16:31 AI and Speech Analysis in Mental Health01:29:31 Advice, Fail More, Learn MoreWorks mentioned:34:59 - Marek, S. et al. (2022). Reproducible brain-wide association studies require thousands of individuals. https://doi.org/10.1038/s41586-022-04492-943:44 - Ghosh, Satrajit (2025). An Intelligent Infrastructure as a Foundation for Modern Science.https://doi.org/10.48550/arXiv.2508.1005101:09:33  - Margulies, Daniel S., et al. (2016).  Situating the default-mode network along a principal gradient of macroscale cortical organization. https://doi.org/10.1073/pnas.160828211301:10:13 - Xavier Guell, Jeremy D Schmahmann, John DE Gabrieli, Satrajit S Ghosh (2018). Functional gradients of the cerebellum. https://doi.org/10.7554/eLife.36652Tools and resources mentioned:Nipype : an open-source Python framework for building reproducible neuroimaging workflows.https://nipype.readthedocs.io/en/latest/index.htmlfMRIPrep : a robust, analysis-agnostic preprocessing pipeline for functional MRI. https://fmriprep.org/en/stable/OpenScope : an open-science effort for large-scale neuroscience data sharing and analysis.https://www.allenneuraldynamics.org/projects/openscopeDANDI : a platform for publishing, sharing, and processing neurophysiology data. https://about.dandiarchive.org/NeuroVault : A public repository of unthresholded statistical maps, parcellations, and atlases of the brain.https://neurovault.org/Episode producers:Ömer Faruk Gülban, Karthik Sama

Dr. Rosy Boa shares a previously unavailable talk outlining three research-based areas to help pole freestyling feel easier and more natural: a mastery mindset, moving to music, and reducing self-consciousness. Drawing on improvisation research (largely from jazz and musical improvisation), she explains that improvisation relies on generating and selecting familiar movement options, so dancers are more likely to access skills they can execute successfully about 90% of the time; mastery approaches are also linked to less perfectionism and better body appreciation. She then summarizes entrainment research showing dance training improves rhythmic synchronization, and that music with strong, predictable beats, some complexity, familiarity, and slower tempo is easier to move to, while metrically complex or unfamiliar music is harder. Finally, she notes that watching oneself (mirrors, filming, self-view on Zoom) increases self-consciousness and can worsen body image, so for flow she recommends avoiding visual self-monitoring and reflecting via journaling and feedback.Are you a pole nerd interested in trying out online pole classes with Slink Through Strength? We'd love to have you! Use the code “podcast” for 10% off the Intro Pack and try out all of our unique online pole classes: https://app.acuityscheduling.com/catalog/25a67bd1/?productId=1828315&clearCart=true Join my newsletter: https://slinkthroughstrength.us10.list-manage.com/subscribe?u=9abf68e29e749e7ee06f01364&id=3d02188de5 Try a free sample class: https://mailchi.mp/slinkthroughstrength.com/free-pole-flow-classChapters:00:00 Welcome and Episode Setup01:28 What You'll Learn Today03:18 Mastery Mindset for Freestyle07:14 Moving to Music Entrainment12:20 Pick Music That Helps Flow13:21 Ditch Mirrors to Lose Self Focus15:11 Three Tips and Wrap Up15:55 Thanks and How to ConnectCitationsLevin, R. (2009). Improvising Mozart. Musical improvisation: Art, education, and society, 143-149.Bloom, Benjamin S. (March 1968). "Learning for Mastery" (PDF). UCLA - CSEIP - Evaluation Comment. Vol. 1.Andrzejewski, C. E., Wilson, A. M., & Henry, D. J. (2013). Considering motivation, goals, and mastery orientation in dance technique. Research in Dance Education, 14(2), 162-175.Cary, G. (2023). Dancing like Everyone's Watching: The Impact of Competition-Contingent Self-Worth and Belonging on Dancers' Mental Well-Being (Doctoral dissertation).Brown, S., Martinez, M. J., & Parsons, L. M. (2006). The neural basis of human dance. Cerebral cortex, 16(8), 1157-1167.Washburn, A., DeMarco, M., de Vries, S., Ariyabuddhiphongs, K., Schmidt, R. C., Richardson, M. J., & Riley, M. A. (2014). Dancers entrain more effectively than non-dancers to another actor's movements. Frontiers in human neuroscience, 8, 800.Madison, G., Gouyon, F., Ullén, F., & Hörnström, K. (2011). Modeling the tendency for music to induce movement in humans: first correlations with low-level audio descriptors across music genres.Weineck, K., Wen, O. X., & Henry, M. J. (2022). Neural synchronization is strongest to the spectral flux of slow music and depends on familiarity and beat salience. Elife, 11, e75515.Nakamura J, Csikszentmihályi M (20 December 2001). "Flow Theory and Research". In Snyder CR, Lopez SJ (eds.). Handbook of Positive Psychology. Oxford University Press. pp. 195–206. ISBN 978-0-19-803094-2. Retrieved 20 November 2013.Radell, S. A., Mandradjieff, M. P., Adame, D. D., & Cole, S. P. (2020). Impact of mirrors on body image of beginning modern and ballet students. Journal of Dance Medicine & Science, 24(3), 126-134.

In the Cretaceous Period (c.100 million years ago) Egypt and North Africa were radically different environments. With vast tidal flats and mangroves, and a shallow sea, the continent fostered numerous animal and plant species. Creatures like Paralititan (sauropods); the sprinting Deltadromeus; the infamous Spinosaurus; and the newcomer Tameryraptor. These have been preserved in the fossil record from Egypt and other countries in North Africa. Today, we meet some of the inhabitants of this ancient landscape… Logo image: Spinosaurus aegyptiacus, by Paleogeeksquared, via Wikimedia. Animals mentioned in this episode: Paralititan: https://en.wikipedia.org/wiki/Paralititan Deltadromeus: https://en.wikipedia.org/wiki/Deltadromeus Mawsonia: https://en.wikipedia.org/wiki/Mawsonia_(fish) Leptostomia: https://en.wikipedia.org/wiki/Leptostomia Spinosaurus: https://en.wikipedia.org/wiki/Spinosaurus Tameryraptor: https://en.wikipedia.org/wiki/Tameryraptor Select references: Dal Sasso, C., Maganuco, S., & Iurino, D. (2014). Update on the internal structure of the snout of Spinosaurus aegyptiacus. Second North African Vertebrate Palaeontology Congress, Ouarzazate. Darwish, M. H., & Attia, Y. (2007). Plant impressions from the mangrove-dinosaur Unit of the Upper Cretaceous Bahariya Formation of Egypt. Taeckholmia, 27, 105--125. Hone, D., & Holtz Jr, T. R. (2021). Evaluating the ecology of Spinosaurus: Shoreline generalist or aquatic pursuit specialist? Palaeontologia Electronica, 24(1), 1–28. https://doi.org/10.26879/1110 Hone, D., & Witton, M. P. (2025). Spinosaur Tales: The Biology and Ecology of the Spinosaurs. Ibrahim, N., Sereno, P. C., Dal Sasso, C., Maganuco, S., Fabbri, M., Martill, D. M., Zouhri, S., Myhrvold, N., & Iurino, D. A. (2014). Semiaquatic adaptations in a giant predatory dinosaur. Science, 345(6204), 1613--1616. https://doi.org/10.1126/science.1258750 Roach, J. (2001, May 31). “Tidal Giant” Roamed Coastal Swamps of Ancient Africa. National Geographic News. https://web.archive.org/web/20010605022420/http://news.nationalgeographic.com/news/2001/05/0531_tidaldinosaur.html Sereno, P. C., Myhrvold, N., Henderson, D. M., Fish, F. E., Vidal, D., Baumgart, S. L., Keillor, T. M., Formoso, K. K., & Conroy, L. L. (2022). Spinosaurus is not an aquatic dinosaur. eLife, 11, e80092. https://doi.org/10.7554/eLife.80092 Smith, J. B., Lamanna, M. C., Lacovara, K. J., Dodson, P., Smith, J. R., Poole, J. C., Giegengack, R., & Attia, Y. (2001). A Giant Sauropod Dinosaur from an Upper Cretaceous Mangrove Deposit in Egypt. Science, 292(5522), 1704--1706. https://doi.org/10.1126/science.1060561 Learn more about your ad choices. Visit megaphone.fm/adchoices

1) Les filles sont parfaites pour les sciences ! 48 portraits pour bousculer les stéréotypes Les filles sont parfaites pour les sciences ! Si vous en doutiez encore, cet ouvrage en fournit la preuve avec 48 portraits de chercheuses et dʹingénieures engagées dans la recherche actuelle. On y découvre leurs passions, leurs doutes et les obstacles quʹelles ont dû franchir. 2) Quand lʹinstinct paternel est apparu chez les animaux et chez lʹhumain Comment lʹinstinct paternel sʹest-il développé pour quʹau 21e siècle des pères soient capables de prendre soin des tout petits aussi bien que les mères ne lʹont fait traditionnellement ? À moins quʹil nʹait toujours été là, tapi dans notre biologie, ne demandant que le bon contexte culturel pour sʹépanouir pleinement. 3) Quand notre cerveau reconnaît la voix des chimpanzés Le cerveau humain ne réagit pas seulement aux voix de ses semblables. Une étude de lʹUniversité de Genève, publiée dans la revue eLife, montre quʹil sʹactive aussi face aux vocalisations des chimpanzés, nos plus proches cousins. Grâce à lʹimagerie par résonance magnétique fonctionnelle, les chercheurs et chercheuses ont observé lʹactivation du gyrus temporal supérieur, une région clé du cortex auditif impliquée dans le traitement des sons liés au langage, à la musique et aux émotions, lorsque des volontaires écoutaient des vocalises de chimpanzés.

Aperol-Spritz auf dem ersten Date, toxische Trink-Männlichkeit und die einzig wahre Frage: Wie viel Promille Unterschied sind in einer Beziehung eigentlich noch okay?

In this episode of the Epigenetics Podcast, we talked with Anders Sejr Hansen from MIT about his work on the impact of 3D genome structures on gene expression, the roles of proteins like CTCF and cohesin, and advanced techniques like Region Capture Micro-C for mapping genome organisation. Dr. Sejr Hansen introduces his research focusing on the relationship between three-dimensional genome structure and function, specifically how these structures can influence gene expression. He elaborates on the importance of transcription factors and the role of looping structures in gene regulation, emphasizing the implications of his work for understanding gene functionality in the context of both development and disease. The conversation then shifts to discussing loop extrusion and the factors affecting loop stability, primarily CTCF and cohesin. Dr. Sejr Hansen highlights the dynamics of these proteins' binding interactions and how their speeds challenge the notion of stable looping structures in the genome. With a keen interest in CTCF's role, he explains how the protein interacts with DNA and the mechanistic aspects of transcription factor movement, alluding to research findings that reveal that CTCF and cohesin tend to form clusters which may play vital roles in establishing chromatin structure. As the interview progresses, Dr. Sejr Hansen details his transition to leading his own lab at MIT, emphasizing the continuation of his earlier work while expanding into new methodologies for studying chromatin. He underscores the importance of understanding not just the static structures of DNA interactions, but the dynamic nature of these relationships and how they influence gene expression. His lab's recent focus has included using advanced imaging techniques to assess the dynamics of chromatin interactions more precisely. The discussion then touches on specific findings from Dr. Sejr Hansen's lab regarding the relationship between genome organization and double-strand break repair mechanisms. He emphasizes how the repair machinery can affect chromatin structure and underscores the essential role of cohesin in facilitating effective double-strand break repair by keeping broken DNA ends in proximity. He suggests that loop extrusion might help prevent genetic material from diffusing too far apart and improve the efficiency of repair. Dr. Sejr Hansen also discusses innovations in genome mapping techniques, particularly the development of Region Capture Micro-C, which facilitates deeper insights into the three-dimensional organization of the genome. This method allows researchers to achieve significantly higher resolution in their analyses compared to traditional 3D genomics techniques like Hi-C. He outlines the technical process and the implications of their findings, especially regarding enhancer-promoter interactions and the surprisingly promiscuous nature of these relationships. References Anders S Hansen, Iryna Pustova, Claudia Cattoglio, Robert Tjian, Xavier Darzacq (2017) CTCF and cohesin regulate chromatin loop stability with distinct dynamics eLife 6:e25776 https://doi.org/10.7554/eLife.25776 Claudia Cattoglio, Iryna Pustova, Nike Walther, Jaclyn J Ho, Merle Hantsche-Grininger, Carla J Inouye, M Julius Hossain, Gina M Dailey, Jan Ellenberg, Xavier Darzacq, Robert Tjian, Anders S Hansen (2019) Determining cellular CTCF and cohesin abundances to constrain 3D genome models eLife 8:e40164 https://doi.org/10.7554/eLife.40164 Goel, V.Y., Huseyin, M.K. & Hansen, A.S. Region Capture Micro-C reveals coalescence of enhancers and promoters into nested microcompartments. Nat Genet 55, 1048–1056 (2023). https://doi.org/10.1038/s41588-023-01391-1 Related Episodes Biophysical Modeling of 3-D Genome Organization (Leonid Mirny) Unraveling Mechanisms of Chromosome Formation (Job Dekker) Contact Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com

Die Themen in den Wissensnachrichten: +++ Umwandlung von Zellen für Befruchtung gelungen +++ Yoga kann bei Senioren zu Stürzen führen +++ Paradiesvögel tanzen sportlich zur Paarung +++**********Weiterführende Quellen zu dieser Folge:Induction of experimental cell division, Nature Communications, 30. September 2025The effect of an Iyengar yoga-based exercise programme on falls, The Lancet, 23. September 2025Dancing male riflebirds create a dynamic sensory trajectory, Current Biology, 29. September 2025Neue Chance für den Feldhamster in Sachsen, 1. Oktober 2025Adaptations in wing morphology, eLife, 30. September 2025Alle Quellen findet ihr hier.**********Ihr könnt uns auch auf diesen Kanälen folgen: TikTok und Instagram .

In this conversation, you'll hear how a family navigated love, parenting, and special needs with resilience and courage. You'll also learn how being built different is exactly what makes life meaningful. Watch now and discover how you too can live with faith that overcomes.Julia's books:My Name is Tommie: My Story of Hydrocephalus → https://www.amazon.com/My-Name-Tommie-Story-Hydrocephalus/dp/1643002686My Name Is Malia My Story of Growing Up with a Brother With Special Needs → https://www.amazon.com/Malia-Story-Growing-Brother-Special/dp/1638145423Julia's socials:Instagram → https://www.instagram.com/gresselmurray/ Website → https://sites.google.com/view/julia-gressel-murray/homeQuick Quiet Times → https://deepspirituality.com/quick-quiet-times/ E-Life (inclusion as a lifestyle) → e-life.org E-Sports (inclusive sports) → e-sports.orgScriptures:Ephesians 3:20-21 NIV1 John 5:4-5 NRSVProverbs 20:24 TPTHebrews 11:1 NASB95Galatians 5:19-21 NLTGalatians 5:22-23 NIVPsalm 37:1 ERVPsalm 37:4-8 ERV► SUBSCRIBE: https://youtube.com/deepspirituality/?sub_confirmation=1Chapters:00:00 Introduction01:18 Built different05:24 The Murrays10:31 Closer to your destiny13:27 God met us unaware17:04 We are not in control of our lives19:26 Quick quiet times20:03 Instant family of six22:04 Where did faith grab you and bring you through?27:47 Inclusion is bringing people together32:49 God build us up through our life experiences34:21 Friendship carries the faith for us40:45 The Chemistry Lab41:27 The struggle with comparison 49:39 Gratitude is the life God has in mind for you51:58 E-Life and inclusive communities56:10 Julia's books and teaching our children01:02:03 God will build us different as we delight in him

Recognizing a familiar voice is one of the brain's earliest social feats. But what are the brain circuits that let a newborn pick out mom in a crowded nursery? How do they change as kids turn toward friends and the wider world? And what are we learning about why this instinct fails to develop in the autistic brain?This week, host Nicholas Weiler joins Stanford neuroscientist Dan Abrams on the quest to understand the neural “hub” that links our brains' hearing centers to the networks that tag voices as rewarding, social, and worth our attention. The findings could reshape early-intervention strategies for kids on the spectrum.Learn MoreStanford Speech and Social Neuroscience LabParticipate in a StudyCommunity Support ResourcesPublicationsUnderconnectivity between voice-selective cortex and reward circuitry in children with autism (PNAS, 2013) Neural circuits underlying mother's voice perception predict social communication abilities in children (PNAS, 2016) Impaired voice processing in reward and salience circuits predicts social communication in children with autism (eLife, 2019)  A Neurodevelopmental Shift in Reward Circuitry from Mother's to Nonfamilial Voices in Adolescence (Journal of Neuroscience, 2022)Stanford Coverage"The teen brain tunes in less to Mom's voice, more to unfamiliar voices, study finds" (Stanford Medicine, 2022)"Brain wiring explains why autism hinders grasp of vocal emotion, says Stanford Medicine study" (Stanford Medicine, 2023)We want to hear from your neurons! Email us at at neuronspodcast@stanford.eduSend us a text!Thanks for listening! If you're enjoying our show, please take a moment to give us a review on your podcast app of choice and share this episode with your friends. That's how we grow as a show and bring the stories of the frontiers of neuroscience to a wider audience. Learn more about the Wu Tsai Neurosciences Institute at Stanford and follow us on Twitter, Facebook, and LinkedIn.

In this episode Dr Sarah Howard discusses healthy ageing in dogs with Dr Matthew Muir. Topics discussed include: The reason ageing is currently a hot topic. What leads to an increased lifespan and better quality of life? Diet changes that can impact ageing in dogs. Dr Muir discusses what we should avoid in order to increase lifespan. Matthew goes into details of what dogs' diets should look like to prevent disease. How often should we be feeding our pets? What happens to the gut microbiome as dogs get older? Dr Muir delves into supplements that can be beneficial for ageing and emerging tools that are becoming available. The importance of preventative medicine - proactive vs reactive care. Accelerators of biological ageing. Additional resources: https://pubmed.ncbi.nlm.nih.gov/11991408/ https://pmc.ncbi.nlm.nih.gov/articles/PMC11675035/https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2024.1355560/full https://pmc.ncbi.nlm.nih.gov/articles/PMC11505706/ https://www.mdpi.com/1660-3397/18/11/564https://pmc.ncbi.nlm.nih.gov/articles/PMC4936929/ https://pubmed.ncbi.nlm.nih.gov/22216092/ Adams VJ, Watson P, Carmichael S, Gerry S, Penell J, Morgan DM. Exceptional longevity and potential determinants of successful ageing in a cohort of 39 Labrador retrievers: results of a prospective longitudinal study. Acta Vet Scand. 2016;58:29. doi:10.1186/s13028-016-0204-8 Cupp CJ, Jean-Philippe C, Kerr WW, Patil AR. Effect of nutritional interventions on longevity of senior cats. Int J Appl Res Vet Med. 2007;5(3):133–149 Bermingham EN, Patterson KA, Shoveller AK, Fraser K, Butowski CF, Thomas DG. Nutritional needs and health outcomes of ageing cats and dogs: is it time for updated nutrient guidelines? Anim Front. 2024;14(3):5–16. doi:10.1093/af/vfae008 Jackson J, Radford AD, Belshaw Z, Wallis LJ, Kubinyi E, German AJ, Westgarth C. Using veterinary health records at scale to investigate ageing dogs and their common issues in primary care. J Small Anim Pract. 2025;66(2):81–91. doi:10.1111/jsap.13809 Creevy KE, O'Neill DG, Promislow DEL. Morbidity and mortality in elderly dogs – a model for human aging. BMC Vet Res. 2022;18(1):456. doi:10.1186/s12917-022-03518-8 Lewis TW, Wiles BM, Llewellyn-Zaidi AM, Evans KM, O’Neill DG. Longevity and mortality in Kennel Club registered dog breeds in the UK in 2014. Canine Genet Epidemiol. 2018;5:10. doi:10.1186/s40575-018-0066-8 Kealy RD, Lawler DF, Ballam JM, Mantz SL, Biery DN, Greeley EH, Lust G, Segre M, Smith GK, Stowe HD. Effects of diet restriction on life span and age-related changes in dogs. J Am Vet Med Assoc. 2002;220(9):1315–1320. doi:10.2460/javma.2002.220.1315 Guelfi G, Capaccia C, Tedeschi M, Bufalari A, Leonardi L, Cenci-Goga B, Maranesi M. Dog aging: a comprehensive review of molecular, cellular, and physiological processes. Cells. 2024;13(24):2101. doi:10.3390/cells13242101 Laflamme DP. Nutritional care for aging cats and dogs. Vet Clin North Am Small Anim Pract. 2012;42(4):769–791. doi:10.1016/j.cvsm.2012.04.002 Hall JA, Jewell DE. Feeding healthy beagles medium-chain triglycerides, fish oil, and L-carnitine offsets age-related changes in serum fatty acids and carnitine metabolites. PLoS One. 2012;7(11):e49510. doi:10.1371/journal.pone.0049510 Bermingham EN, Patterson KA, Shoveller AK, Fraser K, Butowski CF, Thomas DG. Nutritional needs and health outcomes of ageing cats and dogs: is it time for updated nutrient guidelines? Anim Front. 2024;14(3):5–16. doi:10.1093/af/vfae008 Bray EE, Zheng Z, Tolbert MK, McCoy BM, Kaeberlein M, Kerr KF; Dog Aging Project Consortium. Once-daily feeding is associated with better health in companion dogs: results from the Dog Aging Project. GeroScience. 2022;44(3):1779–1790. doi:10.1007/s11357-022-00575-7 Palaseweenun P, Hagen‐Plantinga EA, Schonewille JT, Koop G, Butre C, Jonathan M, Wierenga PA, Hendriks WH. Urinary excretion of advanced glycation end products in dogs and cats. J Anim Physiol Anim Nutr (Berl). 2021;105(1):149–156. doi:10.1111/jpn.13347 Yang L, Yang L, Cai Y, Luo Y, Wang H, Wang L, Chen J, Liu X, Wu Y, Qin Y, Wu Z, Liu N. Natural mycotoxin contamination in dog food: a review on toxicity and detoxification methods. Ecotoxicol Environ Saf. 2023;257:114948. doi:10.1016/j.ecoenv.2023.114948 Bridglalsingh S, Archer-Hartmann S, Azadi P, Barbier de La Serre C, Remillard RL, Sunvold GD, Bartges JW. Association of four differently processed diets with plasma and urine advanced glycation end products and serum soluble receptor for advanced glycation end products concentration in healthy dogs. J Anim Physiol Anim Nutr (Berl). 2024;108(3):735–751. doi:10.1111/jpn.13927 Marchi PH, Vendramini THA, Perini MP, Zafalon RVA, Amaral AR, Ochamotto VA, Da Silveira JC, Dagli MLZ, Brunetto MA. Obesity, inflammation, and cancer in dogs: review and perspectives. Front Vet Sci. 2022;9:1004122. doi:10.3389/fvets.2022.1004122 Schmid SM, Hoffman JM, Prescott J, Ernst H, Promislow DEL, Creevy KE; Dog Aging Project Consortium. The companion dog as a model for inflammaging: a cross-sectional pilot study. GeroScience. 2024;46(6):5395–5407. doi:10.1007/s11357-024-01217-w Ren J, Li H, Zeng G, Pang B, Wang Q, Wei J. Gut microbiome-mediated mechanisms in aging-related diseases: are probiotics ready for prime time? Front Pharmacol. 2023;14:1178596. doi:10.3389/fphar.2023.1178596 Parker A, Romano S, Ansorge R, Aboelnour A, Le Gall G, Savva GM, Pontifex MG, Telatin A, Baker D, Jones E, Vauzour D, Rudder S, Blackshaw LA, Jeffery G, Carding SR. Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brain. Microbiome. 2022;10:68. doi:10.1186/s40168-022-01262-3 Ulluwishewa D, Anderson RC, McNabb WC, et al. Regulation of tight junction permeability by intestinal bacteria and dietary components. J Nutr. 2011;141(5):769–76. doi:10.3945/jn.110.135657 Cao L, Lee SG, Lim KT, Kim HR. Potential anti-aging substances derived from seaweeds. Mar Drugs. 2020;18(11):564. doi:10.3390/md18110564 Grzeczka A, Graczyk S, Kordowitzki P. Pleiotropic effects of resveratrol on aging-related cardiovascular diseases—what can we learn from research in dogs? Cells. 2024;13(20):1732. doi:10.3390/cells13201732 Kusaba A, Arai T. Shiitake mushroom powder supplementation increases antioxidative activity in dogs. Front Vet Sci. 2024;11:1355560. doi:10.3389/fvets.2024.1355560 Cho HW, Choi S, Seo K, Kim KH, Jeon JH, Kim CH, Lim S, Jeong S, Chun JL. Gut microbiota profiling in aged dogs after feeding pet food contained Hericium erinaceus. J Anim Sci Technol. 2022 Sep;64(5):937-949. Kaur J, Seshadri S, Golla KH, Sampara P. Efficacy and safety of standardized ashwagandha (Withania somnifera) root extract on reducing stress and anxiety in domestic dogs: A randomized controlled trial. J Vet Behav. 2022;51:8–15. Bharani KK, Devarasetti AK, Carey L, Khurana A, Kollipaka R, Hanuman DDV, Chetla VS, Banothu AK. Effects of ashwagandha (Withania somnifera) root extract on aging-related changes in healthy geriatric dogs: A randomized, double-blinded placebo-controlled study. Vet Med Sci. 2024 Sep;10(5):e1556 Sacoor C, Marugg JD, Lima NR, Empadinhas N, Montezinho L. Gut-brain axis impact on canine anxiety disorders: new challenges for behavioral veterinary medicine. Vet Med Int. 2024;2024:2856759. doi:10.1155/2024/2856759 Lee E, Carreras-Gallo N, Lopez L, Turner L, Lin A, Mendez TL, Went H, Tomusiak A, Verdin E, Corley M, Ndhlovu L, Smith R, Dwaraka VB. Exploring the effects of Dasatinib, Quercetin, and Fisetin on DNA methylation clocks: a longitudinal study on senolytic interventions. Aging (Albany NY). 2024;16(4):3088–3106. doi:10.18632/aging.205581 Bitto A, Ito TK, Pineda VV, LeTexier NJ, Huang HZ, Sutlief E, Tung H, Vizzini N, Chen B, Smith K, Meza D, Yajima M, Beyer RP, Kerr KF, Davis DJ, Gillespie CH, Snyder JM, Treuting PM, Kaeberlein M. Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice. eLife. 2016;5:e16351. doi:10.7554/eLife.16351 Urfer SR, Kaeberlein TL, Mailheau S, Bergman PJ, Creevy KE, Promislow DEL, Kaeberlein M. A randomized controlled trial to establish effects of short-term rapamycin treatment in 24 middle-aged companion dogs. GeroScience. 2017;39(2):117–127. doi:10.1007/s11357-017-9972-z Kaeberlein M, Creevy KE, Promislow DEL. The Dog Aging Project: translational geroscience in companion animals. Mamm Genome. 2016;27(7–8):279–288. doi:10.1007/s00335-016-9638- Mulder IE, Schmidt B, Lewis M, Delday M, Stokes CR, Bailey M, Aminov RI, Gill BP, Pluske JR, Mayer CD, Kelly D. Restricting microbial exposure in early life negates the immune benefits associated with gut colonization in environments of high microbial diversity. PLoS One. 2011;6(12):e28279. doi:10.1371/journal.pone.0028279 Hemida M, Vuori KA, Moore R, Anturaniemi J, Hielm-Björkman A. Early life modifiable exposures and their association with owner-reported inflammatory bowel disease symptoms in adult dogs. Front Vet Sci. 2021;8:552350. doi:10.3389/fvets.2021.552350 McMahon JE, Graves JL, Tovar AP, Peloquin M, Greenwood K, Chen FL, Nelson M, McCandless EE, Halioua-Haubold CL, Juarez-Salinas D. Translational immune and metabolic markers of aging in dogs. Sci Rep. 2025;15:14460. doi:10.1038/s41598-025-51976-3 Urfer SR, Kaeberlein M. Desexing dogs: a review of the current literature. Animals (Basel). 2019;9(12):1086. doi:10.3390/ani9121086 Santos JDP, Cunha E, Nunes T, Tavares L, Oliveira M. Relation between periodontal disease and systemic diseases in dogs. Res Vet Sci. 2019;125:136–140. doi:10.1016/j.rvsc.2019.05.011 Selting KA, Ringold R, Husbands B, Pithua PO. Thymidine kinase type 1 and C-reactive protein concentrations in dogs with spontaneously occurring cancer. J Vet Intern Med. 2016;30(4):1159–1166. doi:10.1111/jvim.13954 Urfer SR, Kaeberlein M. Desexing dogs: a review of the current literature. Animals (Basel). 2019;9(12):1086. doi:10.3390/ani9121086 Clark JD, Rager DR, Crowell-Davis S, Evans DL. Housing and exercise of dogs: effects on behaviour, immune function and cortisol concentration. Lab Anim Sci. 1997;47(5):500–510 See omnystudio.com/listener for privacy information.

Today's episode features guest host Michael Upshall (guest editor, Charleston Briefings) who talks with Damien Pattinson, Executive Director, eLife Sciences Publications, Ltd. Damien earned his PhD in neuroscience. After a postdoc at Kings College, London, UK, he began his career in scholarly publishing almost twenty years ago, first joining BMJ as a scientific editor, then PLOS ONE as executive director and then as editorial director, and Research Square as VP of Publishing Innovation.  Damien joined eLife in 2020. In this conversation, he talks about Open Science and the eLife publishing model.  LinkedIn: https://www.linkedin.com/in/mupshall/ https://www.linkedin.com/in/damian-pattinson-b054508/ Twitter: Keywords:  #eLife #OpenScience #OpenResearch #Research #FutureOfResearch #ResearchIntegrity #AcademicResearch #OpenAccess #OpenSource #PeerReview #HigherEducation #LibraryInnovation #Innovation #LibraryJobs #career #collaboration #scholcomm #ScholarlyCommunication #libraries #librarianship #LibraryNeeds #LibraryLove #ScholarlyPublishing #AcademicPublishing #publishing #LibrariesAndPublishers #podcasts

Melvyn Bragg and guests discuss the evolution of lungs and of the first breaths, which can be traced back 400 million years to when animal life spread from rock pools and swamps onto land, as some fish found an evolutionary advantage in getting their oxygen from air rather than water. Breathing with lungs may have started with fish filling their mouths with air and forcing it down into sacs in their chests, like the buccal pumping that frogs do now, and slowly their swimming muscles adapted to work their lungs like bellows. While lungs developed in different ways, there are astonishing continuities: for example, the distinct breathing system that helps tiny birds fly thousands of miles now is also the one that once allowed some dinosaurs to become huge; our hiccups are vestiges of the flight reaction in fish needing more oxygen; and we still breathe through our skins, just not enough to meet our needs.With:Steve Brusatte Professor of Palaeontology and Evolution at the University of EdinburghEmily Rayfield Professor of Palaeobiology at the University of BristolAndJonathan Codd Professor of Integrative Zoology at the University of ManchesterProducer: Simon Tillotson Reading list:Roger B. J. Benson, Richard J. Butler, Matthew T. Carrano and Patrick M. O'Connor, ‘Air-filled postcranial bones in theropod dinosaurs: physiological implications and the ‘reptile'–bird transition' (Biological Reviews: Cambridge Philosophical Society, July 2011)Steve Brusatte, The Rise and Fall of the Dinosaurs: A New History of a Lost World (Mariner Books, 2018)Jennifer A. Clack, Gaining Ground: The Origin and Evolution of Tetrapods (2nd edition, Indiana University Press, 2012)Camila Cupello et al, ‘Lung Evolution in vertebrates and the water-to-land transition' (eLife, July 2022)Andrew Davies and Carl Moore, The Respiratory System (Elsevier, 2010) Kenneth Kardong, Vertebrates: Comparative Anatomy, Function, Evolution (8th edition, McGraw-Hill Education, 2018)Ye Li et al, ‘Origin and stepwise evolution of vertebrate lungs' (Nature Ecology & Evolution, Feb 2025) P. Martin Sander and Marcus Clauss, ‘Sauropod Gigantism' (Science, Oct 2008)Goran Nilsson, Respiratory Physiology of Vertebrates: Life With and Without Oxygen (Cambridge University Press, 2010)Steven F. Perry et al, ‘What came first, the lung or the breath?' (Comparative Biochemistry and Physiology, Part A: Molecular & Integrative Biology, May 2001)Michael J. Stephen, Breath Taking: The Power, Fragility, and Future of Our Extraordinary Lungs (Grove/Atlantic, 2022)Mathew J. Wedel, ‘The evolution of vertebral pneumaticity in sauropod dinosaurs' (Journal of Vertebrate Paleontology, Aug 2010)In Our Time is a BBC Studios Audio ProductionSpanning history, religion, culture, science and philosophy, In Our Time from BBC Radio 4 is essential listening for the intellectually curious. In each episode, host Melvyn Bragg and expert guests explore the characters, events and discoveries that have shaped our world.

In the eLife podcast, a university compost heap has turned up Finland's first documented "giant virus". Also, why monkeys de-sand their supper, and how learning more languages actually makes brain tissue thinner. Then, the link between sugar and neonatal sepsis, and how a cancer controls its hydra host by bestowing it with extra tentacles... Get the references and the transcripts for this programme from the Naked Scientists website

In this powerful episode of Finding Your Niche with Neish, we sit down with Marz Bishop—a dynamic messenger of God, motivational speaker, and founder of L.I.F.E: Life's Institute for Experience. Born from a childhood of hardship and the ongoing battle with sickle cell anemia, Bishop's life story is one of pain, purpose, and preparation. He shares how his personal battles have shaped his bold perspective on life and death, why he's completely at peace with his mortality, and how he uses every challenge as a stepping stone toward his calling. Through his organization, Bishop empowers others to see life's trials as divine training for something greater. This episode is a raw, faith-filled journey of transformation, where we explore how your greatest wounds can become your greatest witness.

Vidcast:  https://www.instagram.com/p/DJ94Fy6NTak/The new vaccine goal: trigger a special type of antibody called broadly neutralizing antibodies (bNAbs) that capably target the lipid membrane surrounding the Human Immunodeficiency Virus.  In so doing, they are able to bind to a hidden part of the virus called MPER, which stands for Membrane-Proximal External Region.  This zone plays a critical role by permitting the virus to attach, fuse, and inject its genetic material into human cells.Computational biologists at San Diego's La Jolla Scripps Research Institute now publish their vaccine blueprint in the journal eLife.  Using computer modeling, they demonstrate that certain structural features in the antibodies help them safely recognize viral lipids without endangering normal cells. Their models also predict that maturation of this type of antibody over time leads to better viral binding without creating autoimmunity.This research data is slated to help design vaccines to harness human immunity for effective and  continuing production of these broadly neutralizing antibodies.  This vaccine approach appears successful and will be preventing dreaded HIV infections….someday soon.https://elifesciences.org/articles/90139https://medicalxpress.com/news/2025-05-antibodies-lipids-path-hiv-vaccines.html#HIV #vaccines #bNAbs #MPER #aids

This week on the show, we're have our sights set on healthy aging. What would it mean to be able to live to 80, 90 or 100 with our cognitive abilities intact and able to maintain an independent lifestyle right to the end of our days? We're joined by Beth Mormino and Anthony Wagner who lead the Stanford Aging and Memory Study, which recruits cognitively healthy older adults to understand what makes their brains particularly resilient — and how more of us could join them in living the dream of healthy aging.Learn MoreStanford Aging and Memory Study (SAMS)Stanford Memory LabMormino LabFurther ReadingAlzheimer's 'resilience signature' predicts who will develop dementia—and how fast (Knight Initiative for Brain Resilience, 2025)Latest Alzheimer's lab tests focus on memory loss, not brain plaques (NPR, 2025)ReferencesTrelle, A. N., ... & Wagner, A. D. (2020). Hippocampal and cortical mechanisms at retrieval explain variability in episodic remembering in older adults. eLife, 9:e55335. doi: 10.7554/eLife.55335 PDF | PMID:32469308Trelle, A. N., ..., Wagner, A. D., Mormino, E. C., & Wilson, E. N. (2025). Plasma Aβ42/Aβ40 is sensitive to early cerebral amyloid accumulation and predicts risk of cognitive decline across the Alzheimer's disease spectrum. Alzheimer's & Dementia, 21:e14442. PDF | PMID:39713875Sheng, J., ..., Mormino, E., & Wagner, A. D. (submitted). Top-down attention and Alzheimer's pathology impact cortical selectivity during learning, influencing episodic memory in older adults.  PreprintEpisode CreditsThis episode was produced by Michael Osborne at 14th Street Studios, with sound design by Morgan Honaker. Our logo is by Aimee Garza. The show is hosted by Nicholas Weiler at Stanford's Wu Tsai Neurosciences Institute and supported in part by the Knight Iniative for Brain Resilience.Get in touchWe want to hear from your neurons! Email us at at neuronspodcast@stanford.edu if you'd be willing to help out with some listener rSend us a text!Thanks for listening! If you're enjoying our show, please take a moment to give us a review on your podcast app of choice and share this episode with your friends. That's how we grow as a show and bring the stories of the frontiers of neuroscience to a wider audience. Learn more about the Wu Tsai Neurosciences Institute at Stanford and follow us on Twitter, Facebook, and LinkedIn.

Pour écouter mon podcast Choses à Savoir Culture Générale:Apple Podcast:https://podcasts.apple.com/fr/podcast/choses-%C3%A0-savoir-culture-g%C3%A9n%C3%A9rale/id1048372492Spotify:https://open.spotify.com/show/3AL8eKPHOUINc6usVSbRo3?si=e794067703c14028----------------------------La température corporelle humaine "normale", établie à 37 °C par le médecin allemand Carl Wunderlich en 1851, n'est aujourd'hui plus d'actualité. Plusieurs études récentes confirment que cette valeur a progressivement diminué au fil des deux derniers siècles. En moyenne, les hommes modernes ont vu leur température chuter de 0,59 °C et les femmes de 0,32 °C. Ainsi aujourd'hui la température moyenne est aujourd'hui autour de 36,6 °C, voire un peu moins. Cette évolution, bien que surprenante à première vue, s'explique scientifiquement par des facteurs biologiques et environnementaux.L'une des hypothèses principales repose sur la baisse généralisée des niveaux d'inflammation chronique dans la population. En effet, au XIXe siècle, les infections bactériennes étaient beaucoup plus fréquentes (tuberculose, syphilis, maladies dentaires, etc.). Elles provoquaient des inflammations durables, stimulant le système immunitaire et augmentant la température de base du corps. Or, avec l'amélioration des conditions sanitaires, l'accès aux antibiotiques, à la vaccination et à une meilleure hygiène, le fardeau infectieux a nettement diminué.Une étude emblématique publiée en 2020 dans la revue eLife par le Pr. Julie Parsonnet et son équipe de l'université de Stanford a confirmé ce phénomène. En analysant plus de 677 000 données de température corporelle collectées aux États-Unis entre 1862 et 2017, les chercheurs ont observé une baisse constante de la température moyenne, décennie après décennie. Selon eux, la diminution de l'inflammation systémique et de l'activité du système immunitaire expliquerait en grande partie cette évolution.Mais ce n'est pas tout : notre mode de vie moderne joue aussi un rôle essentiel. Les êtres humains vivent aujourd'hui dans des environnements thermiquement plus stables et confortables, grâce au chauffage central et à la climatisation. Cette stabilité thermique réduit le besoin pour le corps de réguler activement sa température en produisant de la chaleur – un processus métabolique coûteux en énergie. Moins sollicité, le métabolisme de base ralentit, ce qui peut entraîner une baisse légère mais mesurable de la température corporelle.D'autres facteurs sont évoqués, comme la réduction de l'activité physique, l'évolution de la masse corporelle moyenne, ou encore les modifications de l'alimentation. L'ensemble de ces changements contribue à redéfinir la "norme" physiologique humaine.En somme, la baisse de notre température corporelle est le reflet d'une transformation profonde de notre santé, de notre environnement et de notre mode de vie. Elle ne témoigne pas d'un dysfonctionnement, mais plutôt d'une adaptation biologique à un monde moins hostile et plus maîtrisé. Hébergé par Acast. Visitez acast.com/privacy pour plus d'informations.

La température corporelle humaine "normale", établie à 37 °C par le médecin allemand Carl Wunderlich en 1851, n'est aujourd'hui plus d'actualité. Plusieurs études récentes confirment que cette valeur a progressivement diminué au fil des deux derniers siècles. En moyenne, les hommes modernes ont vu leur température chuter de 0,59 °C et les femmes de 0,32 °C. Ainsi aujourd'hui la température moyenne est aujourd'hui autour de 36,6 °C, voire un peu moins. Cette évolution, bien que surprenante à première vue, s'explique scientifiquement par des facteurs biologiques et environnementaux.L'une des hypothèses principales repose sur la baisse généralisée des niveaux d'inflammation chronique dans la population. En effet, au XIXe siècle, les infections bactériennes étaient beaucoup plus fréquentes (tuberculose, syphilis, maladies dentaires, etc.). Elles provoquaient des inflammations durables, stimulant le système immunitaire et augmentant la température de base du corps. Or, avec l'amélioration des conditions sanitaires, l'accès aux antibiotiques, à la vaccination et à une meilleure hygiène, le fardeau infectieux a nettement diminué.Une étude emblématique publiée en 2020 dans la revue eLife par le Pr. Julie Parsonnet et son équipe de l'université de Stanford a confirmé ce phénomène. En analysant plus de 677 000 données de température corporelle collectées aux États-Unis entre 1862 et 2017, les chercheurs ont observé une baisse constante de la température moyenne, décennie après décennie. Selon eux, la diminution de l'inflammation systémique et de l'activité du système immunitaire expliquerait en grande partie cette évolution.Mais ce n'est pas tout : notre mode de vie moderne joue aussi un rôle essentiel. Les êtres humains vivent aujourd'hui dans des environnements thermiquement plus stables et confortables, grâce au chauffage central et à la climatisation. Cette stabilité thermique réduit le besoin pour le corps de réguler activement sa température en produisant de la chaleur – un processus métabolique coûteux en énergie. Moins sollicité, le métabolisme de base ralentit, ce qui peut entraîner une baisse légère mais mesurable de la température corporelle.D'autres facteurs sont évoqués, comme la réduction de l'activité physique, l'évolution de la masse corporelle moyenne, ou encore les modifications de l'alimentation. L'ensemble de ces changements contribue à redéfinir la "norme" physiologique humaine.En somme, la baisse de notre température corporelle est le reflet d'une transformation profonde de notre santé, de notre environnement et de notre mode de vie. Elle ne témoigne pas d'un dysfonctionnement, mais plutôt d'une adaptation biologique à un monde moins hostile et plus maîtrisé. Hébergé par Acast. Visitez acast.com/privacy pour plus d'informations.

What is the impact of an extra year at school on the brain? Also, how poison dart frogs come by their toxins, using movies to track the developing infant nervous system, the insect-spread bacterial plant parasite that is a mastermind of matchmaking, and a new cancer tool to link disease with the best drugs. Chris Smith takes a look at some of the most powerful papers out this month in eLife... Get the references and the transcripts for this programme from the Naked Scientists website

Disability Ministry Series 'Autism and the Church' with Pastor Russ Ewell Welcome back to the Podcast.  Today we have Russ Ewell, lead pastor of Bay Area Christian Church and father of two children with special needs as our guest.  As a father and an advocate in the special needs community he understands the need for creating inclusive environments for our children.  As a Pastor, he and his wife have launched a free, step-by-step guide to help leaders begin or grow this ministry at their church.  He knows that many Pastors are interested in serving the special needs community, but lack the resources to make this a reality and is meeting the need with this resource. In addition, Russ has create E-Sports and E-Life which are inclusive community programs enabling kids with special needs to participate in sports and activities alongside their peers. As we approaching Autism awareness month, Russ brings a fresh perspective of what is possible for individuals special needs and the greater community.  Let's listen in as we join Russ. BIO Russ Ewell is Executive Minister of the Bay Area Christian Church. A minister for more than 40 years, Russ's teaching is rooted in providing hope for those turned off by tradition, and infused with vision for building the transformative church for which the 21st century public hungers.   Contacts: BACC Website: bacc.cc The Spiritual Resource Ministry will shortly release a manual to assist leaders in establishing ministries for individuals with special needs: http://bacc.cc/srm E-Sports.org https://e-sports.org/ E-life.org https://e-life.org/ Social Media: https://www.instagram.com/the.bacc/ https://www.facebook.com/the.bacc     For a family raising a child with special needs, life can be difficult. There are many storms to weather and struggles to address, and we often feel isolated and alone due to the nature of our circumstances. Families have a need to connect and find resources, a need to be encouraged, and a need for hope as we walk down what can be a very hard road at times. Hope on the Hard Road Special Needs Podcast was created for this purpose. Our vision is to grow a thriving community, where families with children of all ages with special needs can feel connected, be encouraged, and find hope for the road ahead. Connect with Us: If you enjoy this podcast please share us with others and be sure to follow us so won't miss an episode. We'd love to hear from you so please leave us a comment or rating and connect with us on social media or on our website. Email us: info@hopeonthehardroad.org Website: https://hopeonthehardroad.org/ Instagram: https://www.instagram.com/hopeonthehardroad/ Facebook: https://www.facebook.com/hopeonthehardroad/ Facebook Group: https://www.facebook.com/groups/2621447987943459 Free Youtube Resource Library: https://www.youtube.com/playlist?list=PLsSAfvTkSy87X-fEqtVR2qvo7w9UQBuxz  

Time for some semi-structured yet informal musings from god's gayest student-of-the-world, Sarah Schauer! This is Schauer Thoughts, a punderful new pod for left and right brainers! So sit back, relax, and let your frontal lobe mull over a little hopecore. Stop putting off those doctors appointments and go to https://Zocdoc.com/SCHAUER to find and instantly book a top-rated doctor today. Sources: SchizophrenicReads IG - https://www.instagram.com/schizophrenicreads/reel/DCFcALFSZ0-/ Wired to Wonder - Todd Kashdan https://greatergood.berkeley.edu/article/item/wired_to_wonder#:~:text=Part%20of%20the%20answer%20is%20whether%20a,and%20experiences%20are%20transferred%20into%20long%2Dterm%20memory. Abramson, A. (2024, January 1). Hope as the antidote. Monitor on Psychology, 55(1). https://www.apa.org/monitor/2024/01/trends-hope-greater-meaning-life Wamsley EJ. How the brain constructs dreams. Elife. 2020 Jun 8;9:e58874. doi: 10.7554/eLife.58874. PMID: 32508304; PMCID: PMC7279884. How Emotions Are Made - Lisa Feldman Barrett Between Us: How Cultures Create Emotions - Batja Mesquita Follow Sarah: @SarahSchauer To watch the podcast on YouTube: https://www.youtube.com/@sarahschauer3764 Learn more about your ad choices. Visit podcastchoices.com/adchoices

Reintroducing Hawaii's sacred crow to the wildThe world's most endangered crow, the Hawaiian crow or or ʻalalā, is making tentative steps towards a comeback. After going extinct in the wild, only 120 birds remain in captivity, in two facilities operated by the San Diego Zoo. Over the years, researchers have attempted reintroductions in the bird's native habitat on the Big Island of Hawaii, but those efforts have all been unsuccessful. Recently, the team tried something different - reintroducing the birds to a different island than their native home. The initial release happened in October and so far, the team, including Bryce Masuda, has high hopes and positive signs from their latest attempt.Lasers tell us about the pterosaur's unique tailThe great flying reptiles of the dawn of the age of dinosaurs, the pterosaurs, took flight with delicate but flexible internal tail structure that allowed it to work like a kite. Scientists used recently developed technology to enable them to see a lattice-like structure in the soft tissue in the early pterosaur soft tissue that was otherwise invisible to the naked eye. Natalia Jagielska, a paleontologist at the Lyme Regis Museum in Dorset, England, said their kite-like tail vane would have stood upright and could have functioned as a display and to help them in flight. The study was published in the eLife journal, Evolutionary Biology. How gophers help re-seed volcanic landscape with lifeAfter Mt. St. Helens exploded in 1980 it left a shattered, ash-covered, barren landscape behind. But the one-time reintroduction of gophers to one area led to a remarkably fast recovery of plants and other fauna. Forty-years later, changes to the environment are still being documented by  Dr. Mia Maltz, assistant professor of Microbial Ecology and Soil Earth at the University of Connecticut, and her team. They published their research in the journal Frontiers in Microbiomes.Desert ants' magnetic navigationDesert ants that navigate the endless sands of the Sahara use the Earth's magnetic field to find their way, which is not unusual. But unlike other animals like birds and turtles they don't appear to have an internal compass that aligns north and south. Instead they are unique in that they  use a more subtle cue – the polarity of the magnetic field. A study looking at this led by Dr. Pauline Fleischmann, a post-doctoral researcher at the University of Oldenburg in Germany  was published in the journal Current Biology. Celestial body mysteries: dark comets and meteorites from young asteroid families The thousands of small celestial bodies in our solar system are now a bit less mysterious, thanks to several recent discoveries. One group of astronomers have traced back the origins of 84 per cent of all known meteorites that have pummeled Earth to just a few young asteroid families in the asteroid belt. Michaël Marsset, from the European Southern Observatory in Chile, said collisions in the asteroid belt create a collisional cascade that produces fragments, some of which end up raining down on Earth as meteorites. Two of their papers were published in the journal Nature and a third in Astronomy & Astrophysics. Another group of astronomers have identified two populations of stealthy dark comets that are something in between a comet and an asteroid. They've found fourteen of these objects whose orbital motion is comet-like, but which lack a visible tail like regular comets. Davide Farnocchia, a navigation engineer at NASA's Jet Propulsion Lab, said they've found two types of these unusual solar system bodies: larger ones in an elliptical orbit out to Jupiter and smaller ones in orbit around Earth. Their study was published in the journal PNAS.

In this episode of the Epigenetics Podcast, we talked with Vijay Ramani from the Gladstone Institute to talk about his work on Single-Molecule Adenine Methylated Oligonucleosome Sequencing Assay (SAMOSA). Our discussion starts with Vijay Ramani's impactful contributions to the field during his time in Jay Shendure's lab, where he worked on several innovative methods, including RNA proximity ligation. This project was conceived during his graduate studies, aiming to adapt techniques from DNA research to investigate RNA structures—a largely unexplored area at the time. We delved into the nuances of his experiences in graduate school, emphasizing how critical it was to have mentors who provided room for creativity and autonomy in experimental design. Dr. Ramani then shares insights about his foray into developing more refined methodologies, such as in-situ DNA Hi-C, a revolutionary protocol tailored for three-dimensional genomic mapping. He explained the rationale behind his projects, comparing the outcomes with contemporaneous advancements in methods like Micro-C. The discussion highlighted the importance of understanding enzyme bias in chromatin studies and the need for meticulous experimental design to ensure the validity of biological interpretations. We further explored exciting advancements in single-cell genomics, specifically Ramani's work on developing sci-Hi-C. This innovative technique leverages combinatorial indexing to allow high-resolution mapping of chromatin architecture at the single-cell level, a significant leap forward in understanding the complexities of gene regulation. As we progress, Ramani detailed his transition from graduate student to independent investigator starting his own lab. He elaborated on the challenges and excitements associated with establishing his research focus in chromatin structure and function using advanced sequencing technologies. Employing various strategies, including the innovative SAMOSA assay, his research seeks to elucidate the mechanisms by which chromatin structure influences transcriptional regulation. We also discussed the heterogeneity of chromatin and its implications for gene expression. Ramani provided a fascinating perspective on how variations in chromatin structure could affect gene activity, highlighting potential avenues for future research that aims to untangle the complex dynamics at play in both healthy and diseased states.   References Ramani, V., Cusanovich, D., Hause, R. et al. Mapping 3D genome architecture through in situ DNase Hi-C. Nat Protoc 11, 2104–2121 (2016). https://doi.org/10.1038/nprot.2016.126 Nour J Abdulhay, Colin P McNally, Laura J Hsieh, Sivakanthan Kasinathan, Aidan Keith, Laurel S Estes, Mehran Karimzadeh, Jason G Underwood, Hani Goodarzi, Geeta J Narlikar, Vijay Ramani (2020) Massively multiplex single-molecule oligonucleosome footprinting eLife 9:e59404. https://doi.org/10.7554/eLife.59404 Abdulhay, N.J., Hsieh, L.J., McNally, C.P. et al. Nucleosome density shapes kilobase-scale regulation by a mammalian chromatin remodeler. Nat Struct Mol Biol 30, 1571–1581 (2023). https://doi.org/10.1038/s41594-023-01093-6 Nanda, A.S., Wu, K., Irkliyenko, I. et al. Direct transposition of native DNA for sensitive multimodal single-molecule sequencing. Nat Genet 56, 1300–1309 (2024). https://doi.org/10.1038/s41588-024-01748-0   Related Episodes Epigenetic Mechanisms in Genome Regulation and Developmental Programming (James Hackett) Chromatin Profiling: From ChIP to CUT&RUN, CUT&Tag and CUTAC (Steven Henikoff) Split-Pool Recognition of Interactions by Tag Extension (SPRITE) (Mitch Guttman)   Contact Epigenetics Podcast on X Epigenetics Podcast on Instagram Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Epigenetics Podcast on Threads Active Motif on X Active Motif on LinkedIn Email: podcast@activemotif.com

Predicting how influenza viruses will evolve, how deserts decompose matter despite the dry, what worms are revealing about a gene linked to autism, and what makes mice fearful of cat smells. Dr Chris Smith talks to the authors of the latest leading research in eLife... Get the references and the transcripts for this programme from the Naked Scientists website

In this episode of the Epigenetics Podcast, we talked with Maxim Greenberg from the Institute Jacob Monot about his work on epigenetic consequences of DNA methylation in development. In this interview we explore how Dr. Greenbergs work at UCLA involved pioneering experiments on DNA methylation mechanisms and how this period was marked by significant collaborative efforts within a highly competitive yet supportive lab environment that ultimately lead to publications in high impact journals. His transition to a postdoctoral position at the Institut Curie with Deborah Bourc'his harnessed his newfound expertise in mammalian systems, examining chromatin changes and the implications for embryonic development. Dr. Greenberg explained the nuances of his research, particularly how chromatin modifications during early development can influence gene regulatory mechanisms later in life, providing a compelling narrative about the potential long-term impacts of epigenetic changes that occur in utero. Throughout our conversation, we examined the intricate relationship between DNA methylation and Polycomb repression, discussing how these epigenetic mechanisms interact and the functional outcomes of their regulation. Dr. Greenberg's insights into his recent studies reveal a commitment to unraveling the complexities of enhancer-promoter interactions in the context of epigenetic regulation.   References Greenberg, M. V., Ausin, I., Chan, S. W., Cokus, S. J., Cuperus, J. T., Feng, S., Law, J. A., Chu, C., Pellegrini, M., Carrington, J. C., & Jacobsen, S. E. (2011). Identification of genes required for de novo DNA methylation in Arabidopsis. Epigenetics, 6(3), 344–354. https://doi.org/10.4161/epi.6.3.14242 Greenberg, M. V., Glaser, J., Borsos, M., Marjou, F. E., Walter, M., Teissandier, A., & Bourc'his, D. (2017). Transient transcription in the early embryo sets an epigenetic state that programs postnatal growth. Nature genetics, 49(1), 110–118. https://doi.org/10.1038/ng.3718 Greenberg, M., Teissandier, A., Walter, M., Noordermeer, D., & Bourc'his, D. (2019). Dynamic enhancer partitioning instructs activation of a growth-related gene during exit from naïve pluripotency. eLife, 8, e44057. https://doi.org/10.7554/eLife.44057 Monteagudo-Sánchez, A., Richard Albert, J., Scarpa, M., Noordermeer, D., & Greenberg, M. V. C. (2024). The impact of the embryonic DNA methylation program on CTCF-mediated genome regulation. Nucleic acids research, 52(18), 10934–10950. https://doi.org/10.1093/nar/gkae724 Richard Albert, J., Urli, T., Monteagudo-Sánchez, A., Le Breton, A., Sultanova, A., David, A., Scarpa, M., Schulz, M., & Greenberg, M. V. C. (2024). DNA methylation shapes the Polycomb landscape during the exit from naive pluripotency. Nature structural & molecular biology, 10.1038/s41594-024-01405-4. Advance online publication. https://doi.org/10.1038/s41594-024-01405-4   Related Episodes DNA Methylation and Mammalian Development (Déborah Bourc'his) Circulating Epigenetic Biomarkers in Cancer (Charlotte Proudhon) Epigenetic Mechanisms in Genome Regulation and Developmental Programming (James Hackett)   Contact Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com

It's time for the grand finale of 2024! Powermode Episode 76 brings you over two hours of non-stop energy with the ultimate Hardstyle Yearmix. This massive episode celebrates an unforgettable year for Hardstyle and for Primeshock, who dropped a total of 11 tracks in 2024! From crazy melodies to crowd-favorite bangers, this mix is packed with the very best of 2024. Whether you've been with us all year or just tuning in now, this episode is a must listen and the perfect recap of the past 12 months. Buckle up and switch into Powermode; the Hardstyle Yearmix of 2024!

Visit SetSet's website ⁠⁠here⁠⁠, enter 3FOR2 at checkout, and get a deck of cards for free when you buy 2 decks through Christmas Day 2024. You can also find these clinician-backed resources on psilocybin: ⁠The Ultimate Psilocybin Guide⁠ ⁠Micro-Psyched 12-week Microdosing Program⁠"How can microdosing foster personal growth and self-compassion?" In this episode, April Pride continues her conversation with Amy Wong, who introduces her book, Small Doses of Awareness, co-authored with Shin Yi Pei. Amy discusses how microdosing can support mindfulness and emotional balance and provides insights into the practice of cultivating "small doses of awareness" through her guided journal. This episode offers practical guidance on microdosing, ancestral healing, and the spiritual dimensions of psychedelic work.After listening to this episode, you'll understand more about: The benefits of microdosing for mindfulness and emotional resilience How to integrate microdosing practices into daily life Insights from Small Doses of Awareness, a microdosing guided journal The role of self-compassion and self-awareness in psychedelic healingResources More information about Amy's clinical and psychedelic offerings. LINK Order Small Doses of Awareness: A Microdosing Companion LINK Materials referenced in this episode:  2021 Study: Single-blinded) Self-blinding citizen science to explore psychedelic microdosing (Balázs Szigeti, Laura Kartner, Allan Blemings, Fernando Rosas, Amanda Feilding, David J Nutt, Robin L Carhart-Harris, David Erritzoe (2021) Self-blinding citizen science to explore psychedelic microdosing eLife 10:e62878. DOI:  https://doi.org/10.7554/eLife.62878) 2023 Review: Microdosing psychedelics and the risk of cardiac fibrosis and valvulopathy: Comparison to known cardiotoxins(Rouaud, A., Calder, A. E., & Hasler, G. (2024). Microdosing psychedelics and the risk of cardiac fibrosis and valvulopathy: Comparison to known cardiotoxins. Journal of Psychopharmacology, 02698811231225609. DOI: https://doi.org/10.1177/02698811231225609) 2020 Survey: Microdosing psychedelics: Demographics, practices, and psychiatric comorbidities (Anderson et al), Journal of Pharmacology , University of Toronto(Rosenbaum, D., Weissman, C., Anderson, T., Petranker, R., Dinh-Williams, L. A., Hui, K., & Hapke, E. (2020). Microdosing psychedelics: Demographics, practices, and psychiatric comorbidities. Journal of Psychopharmacology, 34(6), 612-622. DOI: https://doi.org/10.1177%2F0269881120908004) 2019 Survey: Self-Rated Effectiveness of Microdosing With Psychedelics for Mental and Physical Health Problems Among Microdosers(Hutten, N. R. P. W., Mason, N. L., Dolder, P. C., & Kuypers, K. P. C. (2019). Self-Rated Effectiveness of Microdosing With Psychedelics for Mental and Physical Health Problems Among Microdosers. Frontiers in psychiatry, 10, 672. https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2019.00672/full)WEB | getsetset.comIG | @getsetsetYouTube | youtube.com/@getsetset Get full access to SetSet with April Pride at aprilpride.substack.com/subscribe

Visit SetSet's website ⁠here⁠, enter 3FOR2 at checkout, and get a deck of cards for free when you buy 2 decks through Christmas Day 2024. You can also find these clinician-backed resources on psilocybin: The Ultimate Psilocybin Guide Micro-Psyched 12-week Microdosing Program"What can MDMA and other psychedelics offer those healing from trauma?" In this episode, April Pride talks with Amy Wong, a licensed clinical social worker and MDMA-assisted therapist, about the profound therapeutic benefits of psychedelics. Amy shares her journey into psychedelic therapy and her work in helping clients transform through carefully guided MDMA and psilocybin experiences. This episode focuses on the impact of MDMA in treating trauma and the challenges surrounding policy and legalization in the psychedelic space.After listening to this episode, you'll understand more about: How MDMA can aid in trauma recovery and emotional processing The role of therapy and guidance in effective psychedelic experiences Key policy challenges and legal considerations in psychedelic therapy Amy's experiences and insights from working as an MDMA-assisted therapistResources More information about Amy's clinical and psychedelic offerings. LINK Order Small Doses of Awareness: A Microdosing Companion LINK Materials referenced in this episode:  2021 Study: Single-blinded) Self-blinding citizen science to explore psychedelic microdosing (Balázs Szigeti, Laura Kartner, Allan Blemings, Fernando Rosas, Amanda Feilding, David J Nutt, Robin L Carhart-Harris, David Erritzoe (2021) Self-blinding citizen science to explore psychedelic microdosing eLife 10:e62878. DOI:  https://doi.org/10.7554/eLife.62878) 2023 Review: Microdosing psychedelics and the risk of cardiac fibrosis and valvulopathy: Comparison to known cardiotoxins(Rouaud, A., Calder, A. E., & Hasler, G. (2024). Microdosing psychedelics and the risk of cardiac fibrosis and valvulopathy: Comparison to known cardiotoxins. Journal of Psychopharmacology, 02698811231225609. DOI: https://doi.org/10.1177/02698811231225609) 2020 Survey: Microdosing psychedelics: Demographics, practices, and psychiatric comorbidities (Anderson et al), Journal of Pharmacology , University of Toronto(Rosenbaum, D., Weissman, C., Anderson, T., Petranker, R., Dinh-Williams, L. A., Hui, K., & Hapke, E. (2020). Microdosing psychedelics: Demographics, practices, and psychiatric comorbidities. Journal of Psychopharmacology, 34(6), 612-622. DOI: https://doi.org/10.1177%2F0269881120908004) 2019 Survey: Self-Rated Effectiveness of Microdosing With Psychedelics for Mental and Physical Health Problems Among Microdosers(Hutten, N. R. P. W., Mason, N. L., Dolder, P. C., & Kuypers, K. P. C. (2019). Self-Rated Effectiveness of Microdosing With Psychedelics for Mental and Physical Health Problems Among Microdosers. Frontiers in psychiatry, 10, 672. https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2019.00672/full)WEB | getsetset.comIG | @getsetsetYouTube | youtube.com/@getsetset Get full access to SetSet with April Pride at aprilpride.substack.com/subscribe

In this episode of the Epigenetics Podcast, we talked with Yadira Soto-Feliciano from MIT about her work on the Menin-MLL complex and the effect of small molecules on its stability in leukemia. We explore the pivotal moments that led her to cancer biology during her graduate studies, where her work included ground-breaking research on the role of the plant homeodomain Finger protein-6 (PHF-6) in leukemia. This work bridged the realms of chromatin accessibility, transcription factors, and cancer cell lineage, providing critical evidence for the concept of lineage plasticity in cancer biology—a topic that has gained significant traction in recent years. Dr. Soto-Feliciano discusses how advances in techniques like CRISPR and ChIP-sequencing have shaped her research, enabling deeper insights into the mechanisms underlying cancer cell identity. As our discussion transitions, Dr. Soto-Feliciano shares her experience in David Allis's lab, illustrating how the collaboration across diverse scientific disciplines enhanced her understanding of chromatin biology and generated significant insights into the mechanics of epigenetic regulation. Highlighting a recent 2023 publication, we unpack her findings related to the conserved molecular switch between MLL1 and MLL3 complexes. These discoveries revealed how the application of small-molecule inhibitors of the menin-MLL interaction can alter gene expression and affect leukemia cells' responses to treatments. We also touch on the operational dynamics within her lab at MIT, established during challenging times marked by the pandemic. Yadira is dedicated to fostering a collaborative and respectful environment among her team, comprised of PhD candidates and research technicians, all sharing a commitment to unraveling the complexities of chromatin regulation. She emphasizes the significance of understanding chromatin scaffold proteins and their role in regulating gene expression and genome organization.   References Soto-Feliciano, Y. M., Bartlebaugh, J. M. E., Liu, Y., Sánchez-Rivera, F. J., Bhutkar, A., Weintraub, A. S., Buenrostro, J. D., Cheng, C. S., Regev, A., Jacks, T. E., Young, R. A., & Hemann, M. T. (2017). PHF6 regulates phenotypic plasticity through chromatin organization within lineage-specific genes. Genes & development, 31(10), 973–989. https://doi.org/10.1101/gad.295857.117 Soto-Feliciano, Y. M., Sánchez-Rivera, F. J., Perner, F., Barrows, D. W., Kastenhuber, E. R., Ho, Y. J., Carroll, T., Xiong, Y., Anand, D., Soshnev, A. A., Gates, L., Beytagh, M. C., Cheon, D., Gu, S., Liu, X. S., Krivtsov, A. V., Meneses, M., de Stanchina, E., Stone, R. M., Armstrong, S. A., … Allis, C. D. (2023). A Molecular Switch between Mammalian MLL Complexes Dictates Response to Menin-MLL Inhibition. Cancer discovery, 13(1), 146–169. https://doi.org/10.1158/2159-8290.CD-22-0416 Zhu, C., Soto-Feliciano, Y. M., Morris, J. P., Huang, C. H., Koche, R. P., Ho, Y. J., Banito, A., Chen, C. W., Shroff, A., Tian, S., Livshits, G., Chen, C. C., Fennell, M., Armstrong, S. A., Allis, C. D., Tschaharganeh, D. F., & Lowe, S. W. (2023). MLL3 regulates the CDKN2A tumor suppressor locus in liver cancer. eLife, 12, e80854. https://doi.org/10.7554/eLife.80854   Related Episodes MLL Proteins in Mixed-Lineage Leukemia (Yali Dou) Targeting COMPASS to Cure Childhood Leukemia (Ali Shilatifard)   Contact Epigenetics Podcast on Instagram Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com

La relation entre le stress et le blanchiment des cheveux est un sujet qui a intrigué les chercheurs pendant des décennies. Si l'idée que le stress puisse accélérer le grisonnement est souvent évoquée, des études scientifiques récentes ont permis de mieux comprendre les mécanismes biologiques impliqués et de confirmer cette hypothèse. Le Processus de Pigmentation des Cheveux La couleur des cheveux est déterminée par la présence de mélanine, un pigment produit par les mélanocytes situés dans les follicules pileux. Avec l'âge, la production de mélanine diminue naturellement, entraînant le blanchiment progressif des cheveux. Cependant, des facteurs externes, y compris le stress, peuvent influencer ce processus. Le Rôle du Stress Des études sur des modèles animaux et des recherches récentes sur des humains suggèrent que le stress peut effectivement accélérer la dépigmentation des cheveux. En 2020, une étude publiée dans *Nature* a montré que le stress aigu active le système nerveux sympathique, qui libère de la noradrénaline dans les follicules pileux. Cette libération soudaine provoque l'épuisement des cellules souches mélanocytaires, essentielles pour la production de mélanine. Une fois ces cellules souches épuisées, elles ne peuvent plus régénérer la pigmentation, ce qui entraîne le blanchiment des cheveux . Des expériences menées sur des souris ont également mis en évidence ce lien. Les chercheurs ont soumis les souris à un stress intense et ont observé une perte rapide de la pigmentation des poils. Les résultats ont révélé que la libération excessive de noradrénaline provoquait la migration et l'épuisement des cellules souches responsables de la couleur, confirmant un lien direct entre le stress et le grisonnement accéléré . Mécanismes Biologiques Le mécanisme par lequel le stress entraîne le blanchiment des cheveux est principalement lié à l'activation du système nerveux sympathique et à la libération d'hormones du stress, telles que l'adrénaline et le cortisol. Une autre étude, publiée dans *Cell*, a montré que le stress chronique pouvait également affecter la régénération des cellules souches dans d'autres parties du corps, soulignant l'impact global du stress sur la biologie cellulaire . Stress et Blanchiment Réversible ? Une question importante est de savoir si les effets du stress sur le grisonnement sont réversibles. Bien que les effets du stress aigu puissent conduire à un épuisement permanent des cellules souches mélanocytaires, les chercheurs ont observé que dans certains cas de stress temporaire ou modéré, les cheveux peuvent retrouver leur couleur normale une fois que le stress est réduit. Une étude publiée dans *eLife* en 2021 a démontré que certains cheveux gris redevenaient pigmentés après une réduction significative du stress chez les participants, suggérant que le processus pourrait être, dans certains cas, partiellement réversible . Conclusion En résumé, les preuves scientifiques indiquent clairement que le stress peut accélérer le processus de blanchiment des cheveux en perturbant les cellules souches responsables de la production de mélanine. Le mécanisme principal implique la libération de noradrénaline et d'autres hormones du stress, qui épuisent ces cellules souches. Toutefois, dans certains cas, la réduction du stress peut potentiellement inverser partiellement le processus. Ces découvertes soulignent l'impact profond que le stress peut avoir non seulement sur la santé mentale, mais aussi sur la biologie cellulaire et l'apparence physique. Hébergé par Acast. Visitez acast.com/privacy pour plus d'informations.

In this episode of the Epigenetics Podcast, we talked with Carl Wu from John's Hopkins University about his work on nucleosome remodeling, histone variants, and the role of single-molecule imaging in gene regulation. Our discussion starts with Carl Wu sharing his first significant milestones, a paper in "Cell" and the serendipitous discovery of DNA hypersensitive sites, which transformed our understanding of chromatin accessibility and its implications for gene regulation. As we delve into Dr. Wu's specific areas of research, he elaborates on the biochemistry of nucleosome remodeling and the intricate role of chromatin remodeling enzymes like NURF. We discuss how these enzymes employ ATP hydrolysis to reposition nucleosomes, making DNA accessible for transcription. He then explains the collaborative relationship between chromatin remodelers and transcription factors, showcasing the fascinating interplay that governs gene expression and regulatory mechanisms. The conversation takes a deeper turn as we explore Carl Wu's groundbreaking studies on histone variants, particularly H2AZ. He elucidates the role of SWR1 in facilitating the exchange between H2A and H2AZ in nucleosome arrays. The high-resolution structural insights garnered from recent studies reveal how the enzyme mediates histone eviction and insertion with remarkable precision, providing a clearer picture of chromatin dynamics at a molecular level.   References Wu, C., Bingham, P. M., Livak, K. J., Holmgren, R., & Elgin, S. C. (1979). The chromatin structure of specific genes: I. Evidence for higher order domains of defined DNA sequence. Cell, 16(4), 797–806. https://doi.org/10.1016/0092-8674(79)90095-3 Wu, C., Wong, Y. C., & Elgin, S. C. (1979). The chromatin structure of specific genes: II. Disruption of chromatin structure during gene activity. Cell, 16(4), 807–814. https://doi.org/10.1016/0092-8674(79)90096-5 Wu C. (1980). The 5' ends of Drosophila heat shock genes in chromatin are hypersensitive to DNase I. Nature, 286(5776), 854–860. https://doi.org/10.1038/286854a0 Wu, C., Wilson, S., Walker, B., Dawid, I., Paisley, T., Zimarino, V., & Ueda, H. (1987). Purification and properties of Drosophila heat shock activator protein. Science (New York, N.Y.), 238(4831), 1247–1253. https://doi.org/10.1126/science.3685975 Mizuguchi, G., Shen, X., Landry, J., Wu, W. H., Sen, S., & Wu, C. (2004). ATP-driven exchange of histone H2AZ variant catalyzed by SWR1 chromatin remodeling complex. Science (New York, N.Y.), 303(5656), 343–348. https://doi.org/10.1126/science.1090701 Kim, J. M., Visanpattanasin, P., Jou, V., Liu, S., Tang, X., Zheng, Q., Li, K. Y., Snedeker, J., Lavis, L. D., Lionnet, T., & Wu, C. (2021). Single-molecule imaging of chromatin remodelers reveals role of ATPase in promoting fast kinetics of target search and dissociation from chromatin. eLife, 10, e69387. https://doi.org/10.7554/eLife.69387   Related Episodes Multiple challenges of ATAC-Seq, Points to Consider (Yuan Xue) Pioneer Transcription Factors and Their Influence on Chromatin Structure (Ken Zaret) ATAC-Seq, scATAC-Seq and Chromatin Dynamics in Single-Cells (Jason Buenrostro)   Contact Epigenetics Podcast on X Epigenetics Podcast on Instagram Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Epigenetics Podcast on Threads Active Motif on X Active Motif on LinkedIn Email: podcast@activemotif.com

Ist Stress eigentlich schlechter für uns, wenn wir glauben, dass er schlecht ist? Wir alle kennen das Gefühl gestresst zu sein und welche negativen Folgen Stress mit sich ziehen kann. Doch inwieweit spielt unsere Sichtweise auf den Stress eine Rolle in der Stresswahrnehmung? Diesen Fragen gehen Sinja und Boris in dieser Folge auf den Grund. Wie gefällt dir Verstehen, fühlen, glücklich sein? Erzähle es uns hier.Hintergründe und Studien:Keller, A., Litzelman, K., Wisk, L., Maddox, T., Cheng, E., Creswell, P., & Witt, W. (2012). Does the perception that stress affects health matter? The association with health and mortality.. Health psychology : official journal of the Division of Health Psychology, American Psychological Association, 31 5, 677-84 Link zur Studie Nabi, H., Kivimäki, M., Batty, G., Shipley, M., Britton, A., Brunner, E., Vahtera, J., Lemogne, C., Elbaz, A., & Singh‐Manoux, A. (2013). Increased risk of coronary heart disease among individuals reporting adverse impact of stress on their health: the Whitehall II prospective cohort study.. European heart journal, 34 34, 2697-705 Link zur Studie Dhabhar FS, Malarkey WB, Neri E, McEwen BS. Stress-induced redistribution of immune cells--from barracks to boulevards to battlefields: a tale of three hormones--Curt Richter Award winner. Psychoneuroendocrinology. 2012 Sep;37(9):1345-68. doi: 10.1016/j.psyneuen.2012.05.008. Epub 2012 Jun 22. PMID: 22727761; PMCID: PMC3412918. Link zur Studie Kirby, E., Muroy, S., Sun, W., Covarrubias, D., Leong, M., Barchas, L., & Kaufer, D. (2013). Acute stress enhances adult rat hippocampal neurogenesis and activation of newborn neurons via secreted astrocytic FGF2. eLife, 2 Link zur Studie Ell, S.W., Cosley, B. & McCoy, S.K. When bad stress goes good: increased threat reactivity predicts improved category learning performance. Psychon Bull Rev 18, 96–102 (2011). Link zur Studie Crum, A., Salovey, P., & Achor, S. (2013). Rethinking stress: the role of mindsets in determining the stress response.. Journal of personality and social psychology, 104 4, 716-33 . Link zur Studie Crum, A., Santoro, E., Handley-Miner, I., Smith, E., Evans, K., Moraveji, N., Achor, S., & Salovey, P. (2023). Evaluation of the "rethink stress" mindset intervention: A metacognitive approach to changing mindsets.. Journal of experimental psychology. General. Link zur Studie Unsere allgemeinen Datenschutzrichtlinien finden Sie unter https://art19.com/privacy. Die Datenschutzrichtlinien für Kalifornien sind unter https://art19.com/privacy#do-not-sell-my-info abrufbar.

Russ Ewell's first son was born while he and his wife Gail lived in the Washington, DC area. The doctor said to him “Congratulations! You have a son.” Next the doctor said, “He has down syndrome…”. In time, they moved to Silicon Valley. Russ and his wife, Gail's, journey as parents of two children with special needs led them to start: Spiritual Resource Ministry at Bay Area Christian Church, which offers individuals with special needs and their families the ability to thrive spiritually alongside their neurotypical peers in every area of the church, which they may not otherwise be able to do. E-Sports and E-Life are free, inclusive community programs across the Bay Area enabling kids with special needs to participate in sports and activities alongside their neurotypical peers. Hope Technology School is a private, non-profit, non-sectarian K-12 school, started by Russ and Gail. HTS serves neurotypical kids and kids with special needs from all backgrounds and operates independently of BACC. HTS is regularly recognized as one of the best private schools in the Bay Area. Digital Scribbler, a company Russ founded which develops assistive tech tools for individuals with disabilities. They also have developed a Special Needs Ministry Manual that you can download at the Bay Area Christian Church website for free. (https://bacc.cc/small-groups/srm/manual/) Listen as we unpack Russ's Ministry, family life journey, and the tools to help you develop another great ministry in your area! Contact with Russ at: https://russewell.com/ _______________________________ Looking for a new student ministry resource? You can read my book “Burn Up Not Out: A Student Ministry Fire Builder's Guidebook” here: https://amzn.to/3PtBTIy Listen to more episodes from the Youth Worker On Fire Podcast here: https://bit.ly/3saDyYq _______________________________ EPISODE CREDITS Email us at: youthworkeronfire@gmail.com Hosted by: Doug Edwards Theme Song: "The One and Only" by The 808 : Listen to more at https://bit.ly/3FTYIAJ Intro/Outro Voiceover: Michael Helms : https://www.youtube.com/@MichaelTheSoundGuy  Edited by: Secret Roots Music House

In this episode, we continue our discussion of replications. We talk about how to analyze replication studies, which studies are worth replicating, and what is the status of replications in other scientific disciplines.    Shownotes Mack, R. W. (1951). The Need for Replication Research in Sociology. American Sociological Review, 16(1), 93–94. https://doi.org/10.2307/2087978 Smith, N. C. (1970). Replication studies: A neglected aspect of psychological research. American Psychologist, 25(10), 970–975. https://doi.org/10.1037/h0029774 Sidman, M. (1960). Tactics of Scientific Research: Evaluating Experimental Data in Psychology (New edition). Cambridge Center for Behavioral. Ebersole, C. R., Mathur, M. B., Baranski, E., Bart-Plange, D.-J., Buttrick, N. R., Chartier, C. R., Corker, K. S., Corley, M., Hartshorne, J. K., IJzerman, H., Lazarević, L. B., Rabagliati, H., Ropovik, I., Aczel, B., Aeschbach, L. F., Andrighetto, L., Arnal, J. D., Arrow, H., Babincak, P., … Nosek, B. A. (2020). Many Labs 5: Testing Pre-Data-Collection Peer Review as an Intervention to Increase Replicability. Advances in Methods and Practices in Psychological Science. https://doi.org/10.1177/2515245920958687 Isager, P. M., van Aert, R. C. M., Bahník, Š., Brandt, M. J., DeSoto, K. A., Giner-Sorolla, R., Krueger, J. I., Perugini, M., Ropovik, I., van 't Veer, A. E., Vranka, M., & Lakens, D. (2023). Deciding what to replicate: A decision model for replication study selection under resource and knowledge constraints. Psychological Methods, 28(2), 438–451. https://doi.org/10.1037/met0000438 Aldhous, P. (2011). Journal rejects studies contradicting precognition. New Scientist. https://www.newscientist.com/article/dn20447-journal-rejects-studies-contradicting-precognition/ Stanley, D. J., & Spence, J. R. (2014). Expectations for Replications: Are Yours Realistic? Perspectives on Psychological Science, 9(3), 305–318. https://doi.org/10.1177/1745691614528518 Simonsohn, U. (2015). Small telescopes: Detectability and the evaluation of replication results. Psychological Science, 26(5), 559–569. https://doi.org/10.1177/0956797614567341 Nosek, B.A., Errington, T.M. (2017) Reproducibility in Cancer Biology: Making sense of replications. eLife 6:e23383. https://doi.org/10.7554/eLife.23383      

LaQuita Mason, a Healthcare Administrator with a Master's Degree in Healthcare Administration concentrating in Long-Term Care, symbolizes excellence in the healthcare business. With over 18 years of broad experience, including a decade of duty in the United States Air Force, her path is defined by extraordinary accomplishments and a profound dedication to excellent care. Her […]

Killer whales are likely ramming boats because they're bored and having funSeveral years ago a small population of killer whales living off the coast of Spain began attacking boats, particularly sailboats, damaging some severely and even sinking a handful. While social media speculation has suggested whale rage as a cause, an international team of killer whale experts recently published a report suggesting the behaviour is not aggression, but is instead an example of these giant social creatures just playing and having fun with a toy. We speak with two contributors to the report: John Ford, research scientist emeritus at the Pacific Biological Station with Fisheries & Oceans Canada, and Renaud de Stephanis, the president of Spanish conservation group CIRCE.4,000-year-old Egyptian skull shows signs of possible surgery for brain cancerResearchers studying the history of cancer in human history recently hit the jackpot. In a collection of human remains at the University of Cambridge they found two skulls from Egypt, both thousands of years old, that show signs of advanced cancer. One of those skulls bore cut marks around the lesions. Lead study author and University of Santiago de Compostela professor Edgard Camarós said that regardless of whether these cuts were made as attempts at treatment or a post-mortem investigation, they show off the sophisticated medical knowledge of ancient Egyptians — and can also help better understand the evolution of cancer.This study was published in Frontiers in Medicine.Gorillas' tiny penises and low sperm count can help us understand infertility in humansGorillas are the biggest of the great apes, but their reproductive anatomy is diminutive. The males have small penises and testes, and low sperm quality. A new genetic analysis, published in the scientific journal eLife, identified the mutations that are responsible for male gorillas' peculiar fertility. Vincent Lynch, an associate professor of biological sciences at the State University of New York at Buffalo, said these findings can help us better understand the genes responsible for lower sperm quality in humans.1Illuminating plumes of hot magma in the Earth's mantle with earthquake seismic dataTo understand the source of the magma fueling volcanic eruptions, scientists are using another significant geological event: earthquakes. The seismic waves that earthquakes send through our planet can shine a light on the chimneys of magma that connect the core of the Earth through the mantle to the surface. Karin Sigloch, a professor of geophysics at CNRS — France's National Centre for Scientific Research, is part of an international effort to deploy seismic sensors throughout the oceans to illuminate the mantle plumes. Their research from recent observations in the Indian Ocean around Réunion Island was in Nature Geoscience. It's intelligence all the way down: How cells, tissues and organs have their own smartsWe tend to think of collective intelligence as something we see among animals that work cooperatively to solve problems, like in an ant colony, a school of fish or flock of birds. But biologist Michael Levin, from Harvard and Tufts' universities, thinks collective intelligence also extends to functions within the cell, all the way up to networks of cells, tissues and even organs. He suggests evolution has granted simpler biological layers in living systems the ability to flexibly solve problems. In a recent paper in Communications Biology, he argues we can harness these lower level problem-solving capabilities to make significant advances in regenerative medicine, and treating aging and disease.  

In this episode of the Epigenetics Podcast, we talked with Upasna Sharma from UC Santa Cruz about her work a number of interesting projects on H2A.Z and telomeres, the impact of paternal diet on offspring metabolism, and the role of small RNAs in sperm. In this interview Upasna Sharma discusses her work on the study of the paternal diet's impact on offspring metabolism. She reveals the discovery of small non-coding RNAs, particularly tRNA fragments, in mature mammalian sperm that may carry epigenetic information to the next generation. She explains the specific alterations in tRNA fragment levels in response to a low-protein diet and the connections found between tRNA fragments and metabolic status. Dr. Sharma further explains the degradation and stabilization of tRNA fragments in cells and the processes involved in their regulation. She shares their observation of tRNA fragment abundance in epididymal sperm, despite the sperm being transcriptionally silent at that time. This leads to a discussion on the role of the epididymis in the reprogramming of small RNA profiles and the transportation of tRNA fragments through extracellular vesicles. The conversation then shifts towards the potential mechanism of how environmental information could be transmitted to sperm and the observed changes in small RNAs in response to a low-protein diet. Dr. Sharma discusses the manipulation of small RNAs in embryos and mouse embryonic stem cells, revealing their role in regulating specific sets of genes during early development. However, the exact mechanisms that link these early changes to metabolic phenotypes are still being explored. References Sharma, U., Conine, C. C., Shea, J. M., Boskovic, A., Derr, A. G., Bing, X. Y., Belleannee, C., Kucukural, A., Serra, R. W., Sun, F., Song, L., Carone, B. R., Ricci, E. P., Li, X. Z., Fauquier, L., Moore, M. J., Sullivan, R., Mello, C. C., Garber, M., & Rando, O. J. (2016). Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals. Science (New York, N.Y.), 351(6271), 391–396. https://doi.org/10.1126/science.aad6780 Sharma, U., Sun, F., Conine, C. C., Reichholf, B., Kukreja, S., Herzog, V. A., Ameres, S. L., & Rando, O. J. (2018). Small RNAs Are Trafficked from the Epididymis to Developing Mammalian Sperm. Developmental cell, 46(4), 481–494.e6. https://doi.org/10.1016/j.devcel.2018.06.023 Rinaldi, V. D., Donnard, E., Gellatly, K., Rasmussen, M., Kucukural, A., Yukselen, O., Garber, M., Sharma, U., & Rando, O. J. (2020). An atlas of cell types in the mouse epididymis and vas deferens. eLife, 9, e55474. https://doi.org/10.7554/eLife.55474   Related Episodes The Epigenetics of Human Sperm Cells (Sarah Kimmins) Transgenerational Inheritance and Evolution of Epimutations (Peter Sarkies) The Role of Small RNAs in Transgenerational Inheritance in C. elegans (Oded Rechavi)   Contact Epigenetics Podcast on X Epigenetics Podcast on Instagram Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Epigenetics Podcast on Threads Active Motif on X Active Motif on LinkedIn Email: podcast@activemotif.com

A fascinating new look at treating periodontal disease using macrophages differently. Katrina Sanders, RDH takes a look at work coming from Kings College in London related to using telocytes as a regulator of M1 vs M2 macrophages! Resources: More Fast Facts: https://www.ataleoftwohygienists.com/fast-facts/ Katrina Sanders Website: https://www.katrinasanders.com  Katrina Sanders Instagram:   https://www.instagram.com/thedentalwinegenist/  Jing Zhao, Anahid A Birjandi, Mohi Ahmed, Yushi Redhead, Jose Villagomez Olea, Paul Sharpe (2022). Telocytes regulate macrophages in periodontal disease. Published in eLife https://doi.org/10.7554/eLife.72128