Podcasts about ELife

All We Need Is RAVE!!!#hardstyle #hard_dance #euphoric_hardstyle #euphorichardstyle #rawhardstyle #raw_hardstyle #darkhardstyle #dark_hardstyleYouTubeTwitchFacebookVKTrackList:1    Ballerndorf - Ballern watt    2    Maxtreme - WE ARE STARS    3    Twisted Melodiez, Xenopulse, Nvayne - We Will Ignite    4    The Saints, The Purge - OG Raver    5    ALISA FOX - SHOW ME    6    Bloodlust - In The Dark    7    Sub Sonik - My True DNA    8    X-Traikerz - All You Got    9    Quickdrop, Van Heden - Are You Ready    10    Rebelion - Aliens On Acid    11    Sparkz, Revelation - It's Always Been You    12    Mc Livid, Cryex - Rhythm Of The Natives    13    Louis - Statue    14    Refuzion, Cardination - Ghost Inside My Head    15    MJU - Cosmic Dreams    16    Loudar - INNER REVOLUTION    17    E-Life, Audiofreq, Stephanie Magic - Time To Push It    18    Strixter - Falling Down (Revizion Remix)    19    DEEZL - The Sky    20    Universe Controller, Divisium, Yuuja - S.O.S    21    OddyMatt - DA MOMENT    22    Releazer - Break My Heart    23    Vydrax - Dreams    24    Dejection - Needed Me    25    Vasto, Infliction - Like & Comment    26    Vazooka - Nasty Bassline    27    NGMA - Dancing    28    MC Flo, Heavy Resistance - Straight To Tha Bone

In this powerful episode of Finding Your Niche with Neish, we sit down with Marz Bishop—a dynamic messenger of God, motivational speaker, and founder of L.I.F.E: Life's Institute for Experience. Born from a childhood of hardship and the ongoing battle with sickle cell anemia, Bishop's life story is one of pain, purpose, and preparation. He shares how his personal battles have shaped his bold perspective on life and death, why he's completely at peace with his mortality, and how he uses every challenge as a stepping stone toward his calling. Through his organization, Bishop empowers others to see life's trials as divine training for something greater. This episode is a raw, faith-filled journey of transformation, where we explore how your greatest wounds can become your greatest witness.

This week on the show, we're have our sights set on healthy aging. What would it mean to be able to live to 80, 90 or 100 with our cognitive abilities intact and able to maintain an independent lifestyle right to the end of our days? We're joined by Beth Mormino and Anthony Wagner who lead the Stanford Aging and Memory Study, which recruits cognitively healthy older adults to understand what makes their brains particularly resilient — and how more of us could join them in living the dream of healthy aging.Learn MoreStanford Aging and Memory Study (SAMS)Stanford Memory LabMormino LabFurther ReadingAlzheimer's 'resilience signature' predicts who will develop dementia—and how fast (Knight Initiative for Brain Resilience, 2025)Latest Alzheimer's lab tests focus on memory loss, not brain plaques (NPR, 2025)ReferencesTrelle, A. N., ... & Wagner, A. D. (2020). Hippocampal and cortical mechanisms at retrieval explain variability in episodic remembering in older adults. eLife, 9:e55335. doi: 10.7554/eLife.55335 PDF | PMID:32469308Trelle, A. N., ..., Wagner, A. D., Mormino, E. C., & Wilson, E. N. (2025). Plasma Aβ42/Aβ40 is sensitive to early cerebral amyloid accumulation and predicts risk of cognitive decline across the Alzheimer's disease spectrum. Alzheimer's & Dementia, 21:e14442. PDF | PMID:39713875Sheng, J., ..., Mormino, E., & Wagner, A. D. (submitted). Top-down attention and Alzheimer's pathology impact cortical selectivity during learning, influencing episodic memory in older adults.  PreprintEpisode CreditsThis episode was produced by Michael Osborne at 14th Street Studios, with sound design by Morgan Honaker. Our logo is by Aimee Garza. The show is hosted by Nicholas Weiler at Stanford's Wu Tsai Neurosciences Institute and supported in part by the Knight Iniative for Brain Resilience.Get in touchWe want to hear from your neurons! Email us at at neuronspodcast@stanford.edu if you'd be willing to help out with some listener rSend us a text!Thanks for listening! If you're enjoying our show, please take a moment to give us a review on your podcast app of choice and share this episode with your friends. That's how we grow as a show and bring the stories of the frontiers of neuroscience to a wider audience. Learn more about the Wu Tsai Neurosciences Institute at Stanford and follow us on Twitter, Facebook, and LinkedIn.

Pour écouter mon podcast Choses à Savoir Culture Générale:Apple Podcast:https://podcasts.apple.com/fr/podcast/choses-%C3%A0-savoir-culture-g%C3%A9n%C3%A9rale/id1048372492Spotify:https://open.spotify.com/show/3AL8eKPHOUINc6usVSbRo3?si=e794067703c14028----------------------------La température corporelle humaine "normale", établie à 37 °C par le médecin allemand Carl Wunderlich en 1851, n'est aujourd'hui plus d'actualité. Plusieurs études récentes confirment que cette valeur a progressivement diminué au fil des deux derniers siècles. En moyenne, les hommes modernes ont vu leur température chuter de 0,59 °C et les femmes de 0,32 °C. Ainsi aujourd'hui la température moyenne est aujourd'hui autour de 36,6 °C, voire un peu moins. Cette évolution, bien que surprenante à première vue, s'explique scientifiquement par des facteurs biologiques et environnementaux.L'une des hypothèses principales repose sur la baisse généralisée des niveaux d'inflammation chronique dans la population. En effet, au XIXe siècle, les infections bactériennes étaient beaucoup plus fréquentes (tuberculose, syphilis, maladies dentaires, etc.). Elles provoquaient des inflammations durables, stimulant le système immunitaire et augmentant la température de base du corps. Or, avec l'amélioration des conditions sanitaires, l'accès aux antibiotiques, à la vaccination et à une meilleure hygiène, le fardeau infectieux a nettement diminué.Une étude emblématique publiée en 2020 dans la revue eLife par le Pr. Julie Parsonnet et son équipe de l'université de Stanford a confirmé ce phénomène. En analysant plus de 677 000 données de température corporelle collectées aux États-Unis entre 1862 et 2017, les chercheurs ont observé une baisse constante de la température moyenne, décennie après décennie. Selon eux, la diminution de l'inflammation systémique et de l'activité du système immunitaire expliquerait en grande partie cette évolution.Mais ce n'est pas tout : notre mode de vie moderne joue aussi un rôle essentiel. Les êtres humains vivent aujourd'hui dans des environnements thermiquement plus stables et confortables, grâce au chauffage central et à la climatisation. Cette stabilité thermique réduit le besoin pour le corps de réguler activement sa température en produisant de la chaleur – un processus métabolique coûteux en énergie. Moins sollicité, le métabolisme de base ralentit, ce qui peut entraîner une baisse légère mais mesurable de la température corporelle.D'autres facteurs sont évoqués, comme la réduction de l'activité physique, l'évolution de la masse corporelle moyenne, ou encore les modifications de l'alimentation. L'ensemble de ces changements contribue à redéfinir la "norme" physiologique humaine.En somme, la baisse de notre température corporelle est le reflet d'une transformation profonde de notre santé, de notre environnement et de notre mode de vie. Elle ne témoigne pas d'un dysfonctionnement, mais plutôt d'une adaptation biologique à un monde moins hostile et plus maîtrisé. Hébergé par Acast. Visitez acast.com/privacy pour plus d'informations.

La température corporelle humaine "normale", établie à 37 °C par le médecin allemand Carl Wunderlich en 1851, n'est aujourd'hui plus d'actualité. Plusieurs études récentes confirment que cette valeur a progressivement diminué au fil des deux derniers siècles. En moyenne, les hommes modernes ont vu leur température chuter de 0,59 °C et les femmes de 0,32 °C. Ainsi aujourd'hui la température moyenne est aujourd'hui autour de 36,6 °C, voire un peu moins. Cette évolution, bien que surprenante à première vue, s'explique scientifiquement par des facteurs biologiques et environnementaux.L'une des hypothèses principales repose sur la baisse généralisée des niveaux d'inflammation chronique dans la population. En effet, au XIXe siècle, les infections bactériennes étaient beaucoup plus fréquentes (tuberculose, syphilis, maladies dentaires, etc.). Elles provoquaient des inflammations durables, stimulant le système immunitaire et augmentant la température de base du corps. Or, avec l'amélioration des conditions sanitaires, l'accès aux antibiotiques, à la vaccination et à une meilleure hygiène, le fardeau infectieux a nettement diminué.Une étude emblématique publiée en 2020 dans la revue eLife par le Pr. Julie Parsonnet et son équipe de l'université de Stanford a confirmé ce phénomène. En analysant plus de 677 000 données de température corporelle collectées aux États-Unis entre 1862 et 2017, les chercheurs ont observé une baisse constante de la température moyenne, décennie après décennie. Selon eux, la diminution de l'inflammation systémique et de l'activité du système immunitaire expliquerait en grande partie cette évolution.Mais ce n'est pas tout : notre mode de vie moderne joue aussi un rôle essentiel. Les êtres humains vivent aujourd'hui dans des environnements thermiquement plus stables et confortables, grâce au chauffage central et à la climatisation. Cette stabilité thermique réduit le besoin pour le corps de réguler activement sa température en produisant de la chaleur – un processus métabolique coûteux en énergie. Moins sollicité, le métabolisme de base ralentit, ce qui peut entraîner une baisse légère mais mesurable de la température corporelle.D'autres facteurs sont évoqués, comme la réduction de l'activité physique, l'évolution de la masse corporelle moyenne, ou encore les modifications de l'alimentation. L'ensemble de ces changements contribue à redéfinir la "norme" physiologique humaine.En somme, la baisse de notre température corporelle est le reflet d'une transformation profonde de notre santé, de notre environnement et de notre mode de vie. Elle ne témoigne pas d'un dysfonctionnement, mais plutôt d'une adaptation biologique à un monde moins hostile et plus maîtrisé. Hébergé par Acast. Visitez acast.com/privacy pour plus d'informations.

What is the impact of an extra year at school on the brain? Also, how poison dart frogs come by their toxins, using movies to track the developing infant nervous system, the insect-spread bacterial plant parasite that is a mastermind of matchmaking, and a new cancer tool to link disease with the best drugs. Chris Smith takes a look at some of the most powerful papers out this month in eLife... Get the references and the transcripts for this programme from the Naked Scientists website

Disability Ministry Series 'Autism and the Church' with Pastor Russ Ewell Welcome back to the Podcast.  Today we have Russ Ewell, lead pastor of Bay Area Christian Church and father of two children with special needs as our guest.  As a father and an advocate in the special needs community he understands the need for creating inclusive environments for our children.  As a Pastor, he and his wife have launched a free, step-by-step guide to help leaders begin or grow this ministry at their church.  He knows that many Pastors are interested in serving the special needs community, but lack the resources to make this a reality and is meeting the need with this resource. In addition, Russ has create E-Sports and E-Life which are inclusive community programs enabling kids with special needs to participate in sports and activities alongside their peers. As we approaching Autism awareness month, Russ brings a fresh perspective of what is possible for individuals special needs and the greater community.  Let's listen in as we join Russ. BIO Russ Ewell is Executive Minister of the Bay Area Christian Church. A minister for more than 40 years, Russ's teaching is rooted in providing hope for those turned off by tradition, and infused with vision for building the transformative church for which the 21st century public hungers.   Contacts: BACC Website: bacc.cc The Spiritual Resource Ministry will shortly release a manual to assist leaders in establishing ministries for individuals with special needs: http://bacc.cc/srm E-Sports.org https://e-sports.org/ E-life.org https://e-life.org/ Social Media: https://www.instagram.com/the.bacc/ https://www.facebook.com/the.bacc     For a family raising a child with special needs, life can be difficult. There are many storms to weather and struggles to address, and we often feel isolated and alone due to the nature of our circumstances. Families have a need to connect and find resources, a need to be encouraged, and a need for hope as we walk down what can be a very hard road at times. Hope on the Hard Road Special Needs Podcast was created for this purpose. Our vision is to grow a thriving community, where families with children of all ages with special needs can feel connected, be encouraged, and find hope for the road ahead. Connect with Us: If you enjoy this podcast please share us with others and be sure to follow us so won't miss an episode. We'd love to hear from you so please leave us a comment or rating and connect with us on social media or on our website. Email us: info@hopeonthehardroad.org Website: https://hopeonthehardroad.org/ Instagram: https://www.instagram.com/hopeonthehardroad/ Facebook: https://www.facebook.com/hopeonthehardroad/ Facebook Group: https://www.facebook.com/groups/2621447987943459 Free Youtube Resource Library: https://www.youtube.com/playlist?list=PLsSAfvTkSy87X-fEqtVR2qvo7w9UQBuxz  

Time for some semi-structured yet informal musings from god's gayest student-of-the-world, Sarah Schauer! This is Schauer Thoughts, a punderful new pod for left and right brainers! So sit back, relax, and let your frontal lobe mull over a little hopecore. Stop putting off those doctors appointments and go to https://Zocdoc.com/SCHAUER to find and instantly book a top-rated doctor today. Sources: SchizophrenicReads IG - https://www.instagram.com/schizophrenicreads/reel/DCFcALFSZ0-/ Wired to Wonder - Todd Kashdan https://greatergood.berkeley.edu/article/item/wired_to_wonder#:~:text=Part%20of%20the%20answer%20is%20whether%20a,and%20experiences%20are%20transferred%20into%20long%2Dterm%20memory. Abramson, A. (2024, January 1). Hope as the antidote. Monitor on Psychology, 55(1). https://www.apa.org/monitor/2024/01/trends-hope-greater-meaning-life Wamsley EJ. How the brain constructs dreams. Elife. 2020 Jun 8;9:e58874. doi: 10.7554/eLife.58874. PMID: 32508304; PMCID: PMC7279884. How Emotions Are Made - Lisa Feldman Barrett Between Us: How Cultures Create Emotions - Batja Mesquita Follow Sarah: @SarahSchauer To watch the podcast on YouTube: https://www.youtube.com/@sarahschauer3764 Learn more about your ad choices. Visit podcastchoices.com/adchoices

Die Themen in den Wissensnachrichten: +++ Omega-3-Fettsäuren könnten Altersveränderungen bremsen +++ Altsteinzeit-Menschen hatten wohl schon Piercings +++ Koffein schützt vermutlich Mate-Pflanze +++**********Weiterführende Quellen zu dieser Folge:Individual and additive effects of vitamin D, omega-3 and exercise on DNA methylation clocks of biological aging in older adults from the DO-HEALTH trial, Nature Aging, 03.02.2025Probable Use of Labrets Among the Mid Upper Paleolithic Pavlovian Peoples of Central Europe, Journal of Paleolithic Archaeology, 23.01.2025Yerba mate (Ilex paraguariensis) genome provides new insights into convergent evolution of caffeine biosynthesis, Elife, 08.01.2025Bioaccumulation of microplastics in decedent human brains, Nature Medicine, 03.02.2025Local chemical heterogeneity enabled superior zero thermal expansion in nonstoichiometric pyrochlore magnets, National Science Review, 17.12.2024Alle Quellen findet ihr hier.**********Ihr könnt uns auch auf diesen Kanälen folgen: TikTok auf&ab , TikTok wie_geht und Instagram .

Reintroducing Hawaii's sacred crow to the wildThe world's most endangered crow, the Hawaiian crow or or ʻalalā, is making tentative steps towards a comeback. After going extinct in the wild, only 120 birds remain in captivity, in two facilities operated by the San Diego Zoo. Over the years, researchers have attempted reintroductions in the bird's native habitat on the Big Island of Hawaii, but those efforts have all been unsuccessful. Recently, the team tried something different - reintroducing the birds to a different island than their native home. The initial release happened in October and so far, the team, including Bryce Masuda, has high hopes and positive signs from their latest attempt.Lasers tell us about the pterosaur's unique tailThe great flying reptiles of the dawn of the age of dinosaurs, the pterosaurs, took flight with delicate but flexible internal tail structure that allowed it to work like a kite. Scientists used recently developed technology to enable them to see a lattice-like structure in the soft tissue in the early pterosaur soft tissue that was otherwise invisible to the naked eye. Natalia Jagielska, a paleontologist at the Lyme Regis Museum in Dorset, England, said their kite-like tail vane would have stood upright and could have functioned as a display and to help them in flight. The study was published in the eLife journal, Evolutionary Biology. How gophers help re-seed volcanic landscape with lifeAfter Mt. St. Helens exploded in 1980 it left a shattered, ash-covered, barren landscape behind. But the one-time reintroduction of gophers to one area led to a remarkably fast recovery of plants and other fauna. Forty-years later, changes to the environment are still being documented by  Dr. Mia Maltz, assistant professor of Microbial Ecology and Soil Earth at the University of Connecticut, and her team. They published their research in the journal Frontiers in Microbiomes.Desert ants' magnetic navigationDesert ants that navigate the endless sands of the Sahara use the Earth's magnetic field to find their way, which is not unusual. But unlike other animals like birds and turtles they don't appear to have an internal compass that aligns north and south. Instead they are unique in that they  use a more subtle cue – the polarity of the magnetic field. A study looking at this led by Dr. Pauline Fleischmann, a post-doctoral researcher at the University of Oldenburg in Germany  was published in the journal Current Biology. Celestial body mysteries: dark comets and meteorites from young asteroid families The thousands of small celestial bodies in our solar system are now a bit less mysterious, thanks to several recent discoveries. One group of astronomers have traced back the origins of 84 per cent of all known meteorites that have pummeled Earth to just a few young asteroid families in the asteroid belt. Michaël Marsset, from the European Southern Observatory in Chile, said collisions in the asteroid belt create a collisional cascade that produces fragments, some of which end up raining down on Earth as meteorites. Two of their papers were published in the journal Nature and a third in Astronomy & Astrophysics. Another group of astronomers have identified two populations of stealthy dark comets that are something in between a comet and an asteroid. They've found fourteen of these objects whose orbital motion is comet-like, but which lack a visible tail like regular comets. Davide Farnocchia, a navigation engineer at NASA's Jet Propulsion Lab, said they've found two types of these unusual solar system bodies: larger ones in an elliptical orbit out to Jupiter and smaller ones in orbit around Earth. Their study was published in the journal PNAS.

Aujourd'hui, nous parlons de sommeil, mais plus particulièrement d'insomnie et des impacts d'un mauvais sommeil sur notre santé physique et psychologique. En particulier, nous discuterons du fait qu'il existe des solutions pour traiter l'insomnie, mais aussi pour améliorer son sommeil et ses habitudes, que le fait de prendre soin de son sommeil peut avoir des répercussions beaucoup plus grandes que ce qu'on peut imaginer, et qu'il ne faut pas attendre pour adresser les problèmes s'il y en a.Envoyez-nous vos suggestions de sujets pour nos prochains épisodes de podcast. Vous avez de bonnes idées ou il y a des sujets en lien avec la santé métabolique et la perte de poids qui vous intéressent? Écrivez-nous à info@solutions-santé.ca.   Nous recevons Maude Bouchard, qui détient un doctorat en neuropsychologie. Maude cumule plus de 15 ans d'expertise dans le domaine du sommeil. Elle a fait ses études de premier et de deuxième cycle à l'Université de Montréal. Elle a publié ses travaux dans des revues scientifiques réputées telles que Sleep et eLife et a donné de nombreuses conférences nationales et internationales au fil des ans. Animée par une passion pour l'enseignement et le transfert de connaissances, Dre Maude Bouchard a été professeure adjointe au City College de New York et chargée de cours à l'Université de Montréal et à l'Université du Québec à Chicoutimi. Maude Bouchard occupe actuellement le poste de directrice de la recherche et du développement chez HALEO. Expérience personnelle d'Èvelyne avec l'insomnieLesimpacts d'un mauvais sommeil sur notre santé physique et psychologiqueLes impacts positifs d'avoir un meilleur sommeil sur notre humeur et nos émotions, la gestion du stress, nos capacités cognitives et motrices, notre jugement et même notre manière de s'alimenter et notre impulsivité.La thérapie cognitive-comportementale de l'insomnie LA TCC-I comme première ligne de traitement, ce que c'est, les principes derrière et les résultats que ça peut amener sur le sommeil, mais aussi les symptômes d'anxiété, de dépression et la prise de médicaments pour dormir.L'astuce de la semaine donnée par Maude Il faut écouter l'épisode pour la connaître!Les messages clés de l'épisode sont : Il existe des solutions pour traiter l'insomnie, mais aussi pour améliorer son sommeil et ses habitudes. Le fait de prendre soin de son sommeil peut avoir des répercussions beaucoup plus grandes que ce qu'on peut imaginer.Il y a une relation bidirectionnelle entre le sommeil et la santé physique, dont le poids, et la santé mentale. Il faut parler de son sommeil avec son médecin ou les professionnels de la santé dans notre équipe de soin et ne pas attendre pour adresser les problèmes s'il y en a.Pour en savoir plus sur les programmes d'Haleo, pour faire le questionnaire de dépistage ou pour prendre RV :https://questionnaire.haleoclinic.com/home/fr-caRéseaux sociaux : https://www.linkedin.com/company/haleosleep et https://www.facebook.com/haleo.ca et https://www.instagram.com/haleo.clinic/Hébergé par Ausha. Visitez ausha.co/politique-de-confidentialite pour plus d'informations.

In this episode of the Epigenetics Podcast, we talked with Vijay Ramani from the Gladstone Institute to talk about his work on Single-Molecule Adenine Methylated Oligonucleosome Sequencing Assay (SAMOSA). Our discussion starts with Vijay Ramani's impactful contributions to the field during his time in Jay Shendure's lab, where he worked on several innovative methods, including RNA proximity ligation. This project was conceived during his graduate studies, aiming to adapt techniques from DNA research to investigate RNA structures—a largely unexplored area at the time. We delved into the nuances of his experiences in graduate school, emphasizing how critical it was to have mentors who provided room for creativity and autonomy in experimental design. Dr. Ramani then shares insights about his foray into developing more refined methodologies, such as in-situ DNA Hi-C, a revolutionary protocol tailored for three-dimensional genomic mapping. He explained the rationale behind his projects, comparing the outcomes with contemporaneous advancements in methods like Micro-C. The discussion highlighted the importance of understanding enzyme bias in chromatin studies and the need for meticulous experimental design to ensure the validity of biological interpretations. We further explored exciting advancements in single-cell genomics, specifically Ramani's work on developing sci-Hi-C. This innovative technique leverages combinatorial indexing to allow high-resolution mapping of chromatin architecture at the single-cell level, a significant leap forward in understanding the complexities of gene regulation. As we progress, Ramani detailed his transition from graduate student to independent investigator starting his own lab. He elaborated on the challenges and excitements associated with establishing his research focus in chromatin structure and function using advanced sequencing technologies. Employing various strategies, including the innovative SAMOSA assay, his research seeks to elucidate the mechanisms by which chromatin structure influences transcriptional regulation. We also discussed the heterogeneity of chromatin and its implications for gene expression. Ramani provided a fascinating perspective on how variations in chromatin structure could affect gene activity, highlighting potential avenues for future research that aims to untangle the complex dynamics at play in both healthy and diseased states.   References Ramani, V., Cusanovich, D., Hause, R. et al. Mapping 3D genome architecture through in situ DNase Hi-C. Nat Protoc 11, 2104–2121 (2016). https://doi.org/10.1038/nprot.2016.126 Nour J Abdulhay, Colin P McNally, Laura J Hsieh, Sivakanthan Kasinathan, Aidan Keith, Laurel S Estes, Mehran Karimzadeh, Jason G Underwood, Hani Goodarzi, Geeta J Narlikar, Vijay Ramani (2020) Massively multiplex single-molecule oligonucleosome footprinting eLife 9:e59404. https://doi.org/10.7554/eLife.59404 Abdulhay, N.J., Hsieh, L.J., McNally, C.P. et al. Nucleosome density shapes kilobase-scale regulation by a mammalian chromatin remodeler. Nat Struct Mol Biol 30, 1571–1581 (2023). https://doi.org/10.1038/s41594-023-01093-6 Nanda, A.S., Wu, K., Irkliyenko, I. et al. Direct transposition of native DNA for sensitive multimodal single-molecule sequencing. Nat Genet 56, 1300–1309 (2024). https://doi.org/10.1038/s41588-024-01748-0   Related Episodes Epigenetic Mechanisms in Genome Regulation and Developmental Programming (James Hackett) Chromatin Profiling: From ChIP to CUT&RUN, CUT&Tag and CUTAC (Steven Henikoff) Split-Pool Recognition of Interactions by Tag Extension (SPRITE) (Mitch Guttman)   Contact Epigenetics Podcast on X Epigenetics Podcast on Instagram Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Epigenetics Podcast on Threads Active Motif on X Active Motif on LinkedIn Email: podcast@activemotif.com

Predicting how influenza viruses will evolve, how deserts decompose matter despite the dry, what worms are revealing about a gene linked to autism, and what makes mice fearful of cat smells. Dr Chris Smith talks to the authors of the latest leading research in eLife... Get the references and the transcripts for this programme from the Naked Scientists website

Pour cette nouvelle émission, Vanadís reçoit, e-life unit, un duo rennais composé de Blanca Brusci et Swing Loww

In this episode of the Epigenetics Podcast, we talked with Maxim Greenberg from the Institute Jacob Monot about his work on epigenetic consequences of DNA methylation in development. In this interview we explore how Dr. Greenbergs work at UCLA involved pioneering experiments on DNA methylation mechanisms and how this period was marked by significant collaborative efforts within a highly competitive yet supportive lab environment that ultimately lead to publications in high impact journals. His transition to a postdoctoral position at the Institut Curie with Deborah Bourc'his harnessed his newfound expertise in mammalian systems, examining chromatin changes and the implications for embryonic development. Dr. Greenberg explained the nuances of his research, particularly how chromatin modifications during early development can influence gene regulatory mechanisms later in life, providing a compelling narrative about the potential long-term impacts of epigenetic changes that occur in utero. Throughout our conversation, we examined the intricate relationship between DNA methylation and Polycomb repression, discussing how these epigenetic mechanisms interact and the functional outcomes of their regulation. Dr. Greenberg's insights into his recent studies reveal a commitment to unraveling the complexities of enhancer-promoter interactions in the context of epigenetic regulation.   References Greenberg, M. V., Ausin, I., Chan, S. W., Cokus, S. J., Cuperus, J. T., Feng, S., Law, J. A., Chu, C., Pellegrini, M., Carrington, J. C., & Jacobsen, S. E. (2011). Identification of genes required for de novo DNA methylation in Arabidopsis. Epigenetics, 6(3), 344–354. https://doi.org/10.4161/epi.6.3.14242 Greenberg, M. V., Glaser, J., Borsos, M., Marjou, F. E., Walter, M., Teissandier, A., & Bourc'his, D. (2017). Transient transcription in the early embryo sets an epigenetic state that programs postnatal growth. Nature genetics, 49(1), 110–118. https://doi.org/10.1038/ng.3718 Greenberg, M., Teissandier, A., Walter, M., Noordermeer, D., & Bourc'his, D. (2019). Dynamic enhancer partitioning instructs activation of a growth-related gene during exit from naïve pluripotency. eLife, 8, e44057. https://doi.org/10.7554/eLife.44057 Monteagudo-Sánchez, A., Richard Albert, J., Scarpa, M., Noordermeer, D., & Greenberg, M. V. C. (2024). The impact of the embryonic DNA methylation program on CTCF-mediated genome regulation. Nucleic acids research, 52(18), 10934–10950. https://doi.org/10.1093/nar/gkae724 Richard Albert, J., Urli, T., Monteagudo-Sánchez, A., Le Breton, A., Sultanova, A., David, A., Scarpa, M., Schulz, M., & Greenberg, M. V. C. (2024). DNA methylation shapes the Polycomb landscape during the exit from naive pluripotency. Nature structural & molecular biology, 10.1038/s41594-024-01405-4. Advance online publication. https://doi.org/10.1038/s41594-024-01405-4   Related Episodes DNA Methylation and Mammalian Development (Déborah Bourc'his) Circulating Epigenetic Biomarkers in Cancer (Charlotte Proudhon) Epigenetic Mechanisms in Genome Regulation and Developmental Programming (James Hackett)   Contact Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com

It's time for the grand finale of 2024! Powermode Episode 76 brings you over two hours of non-stop energy with the ultimate Hardstyle Yearmix. This massive episode celebrates an unforgettable year for Hardstyle and for Primeshock, who dropped a total of 11 tracks in 2024! From crazy melodies to crowd-favorite bangers, this mix is packed with the very best of 2024. Whether you've been with us all year or just tuning in now, this episode is a must listen and the perfect recap of the past 12 months. Buckle up and switch into Powermode; the Hardstyle Yearmix of 2024!

In deze aflevering van Generatiekloof? onderzoeken we de rol van onafhankelijke labels in de hiphop met René Phillips, oprichter van het invloedrijke CMC Records, en Geert Maes, oprichter van het jonge Fresh Flows Records. René vertelt over zijn pionierswerk in de jaren '90, waarin hij met CMC Records een platform creëerde voor Nederlandse urban artiesten zoals E-Life en Postman. Geert deelt zijn ervaringen als jonge label-eigenaar, gericht op het ondersteunen van artiesten in hun groei en het uitbrengen van hun muziek. Samen bespreken ze de veranderingen in de muziekindustrie, de waarde van onafhankelijke labels, en hun visie op de toekomst van hiphop in Nederland.

Visit SetSet's website ⁠⁠here⁠⁠, enter 3FOR2 at checkout, and get a deck of cards for free when you buy 2 decks through Christmas Day 2024. You can also find these clinician-backed resources on psilocybin: ⁠The Ultimate Psilocybin Guide⁠ ⁠Micro-Psyched 12-week Microdosing Program⁠"How can microdosing foster personal growth and self-compassion?" In this episode, April Pride continues her conversation with Amy Wong, who introduces her book, Small Doses of Awareness, co-authored with Shin Yi Pei. Amy discusses how microdosing can support mindfulness and emotional balance and provides insights into the practice of cultivating "small doses of awareness" through her guided journal. This episode offers practical guidance on microdosing, ancestral healing, and the spiritual dimensions of psychedelic work.After listening to this episode, you'll understand more about: The benefits of microdosing for mindfulness and emotional resilience How to integrate microdosing practices into daily life Insights from Small Doses of Awareness, a microdosing guided journal The role of self-compassion and self-awareness in psychedelic healingResources More information about Amy's clinical and psychedelic offerings. LINK Order Small Doses of Awareness: A Microdosing Companion LINK Materials referenced in this episode:  2021 Study: Single-blinded) Self-blinding citizen science to explore psychedelic microdosing (Balázs Szigeti, Laura Kartner, Allan Blemings, Fernando Rosas, Amanda Feilding, David J Nutt, Robin L Carhart-Harris, David Erritzoe (2021) Self-blinding citizen science to explore psychedelic microdosing eLife 10:e62878. DOI:  https://doi.org/10.7554/eLife.62878) 2023 Review: Microdosing psychedelics and the risk of cardiac fibrosis and valvulopathy: Comparison to known cardiotoxins(Rouaud, A., Calder, A. E., & Hasler, G. (2024). Microdosing psychedelics and the risk of cardiac fibrosis and valvulopathy: Comparison to known cardiotoxins. Journal of Psychopharmacology, 02698811231225609. DOI: https://doi.org/10.1177/02698811231225609) 2020 Survey: Microdosing psychedelics: Demographics, practices, and psychiatric comorbidities (Anderson et al), Journal of Pharmacology , University of Toronto(Rosenbaum, D., Weissman, C., Anderson, T., Petranker, R., Dinh-Williams, L. A., Hui, K., & Hapke, E. (2020). Microdosing psychedelics: Demographics, practices, and psychiatric comorbidities. Journal of Psychopharmacology, 34(6), 612-622. DOI: https://doi.org/10.1177%2F0269881120908004) 2019 Survey: Self-Rated Effectiveness of Microdosing With Psychedelics for Mental and Physical Health Problems Among Microdosers(Hutten, N. R. P. W., Mason, N. L., Dolder, P. C., & Kuypers, K. P. C. (2019). Self-Rated Effectiveness of Microdosing With Psychedelics for Mental and Physical Health Problems Among Microdosers. Frontiers in psychiatry, 10, 672. https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2019.00672/full)WEB | getsetset.comIG | @getsetsetYouTube | youtube.com/@getsetset Get full access to SetSet with April Pride at aprilpride.substack.com/subscribe

Visit SetSet's website ⁠here⁠, enter 3FOR2 at checkout, and get a deck of cards for free when you buy 2 decks through Christmas Day 2024. You can also find these clinician-backed resources on psilocybin: The Ultimate Psilocybin Guide Micro-Psyched 12-week Microdosing Program"What can MDMA and other psychedelics offer those healing from trauma?" In this episode, April Pride talks with Amy Wong, a licensed clinical social worker and MDMA-assisted therapist, about the profound therapeutic benefits of psychedelics. Amy shares her journey into psychedelic therapy and her work in helping clients transform through carefully guided MDMA and psilocybin experiences. This episode focuses on the impact of MDMA in treating trauma and the challenges surrounding policy and legalization in the psychedelic space.After listening to this episode, you'll understand more about: How MDMA can aid in trauma recovery and emotional processing The role of therapy and guidance in effective psychedelic experiences Key policy challenges and legal considerations in psychedelic therapy Amy's experiences and insights from working as an MDMA-assisted therapistResources More information about Amy's clinical and psychedelic offerings. LINK Order Small Doses of Awareness: A Microdosing Companion LINK Materials referenced in this episode:  2021 Study: Single-blinded) Self-blinding citizen science to explore psychedelic microdosing (Balázs Szigeti, Laura Kartner, Allan Blemings, Fernando Rosas, Amanda Feilding, David J Nutt, Robin L Carhart-Harris, David Erritzoe (2021) Self-blinding citizen science to explore psychedelic microdosing eLife 10:e62878. DOI:  https://doi.org/10.7554/eLife.62878) 2023 Review: Microdosing psychedelics and the risk of cardiac fibrosis and valvulopathy: Comparison to known cardiotoxins(Rouaud, A., Calder, A. E., & Hasler, G. (2024). Microdosing psychedelics and the risk of cardiac fibrosis and valvulopathy: Comparison to known cardiotoxins. Journal of Psychopharmacology, 02698811231225609. DOI: https://doi.org/10.1177/02698811231225609) 2020 Survey: Microdosing psychedelics: Demographics, practices, and psychiatric comorbidities (Anderson et al), Journal of Pharmacology , University of Toronto(Rosenbaum, D., Weissman, C., Anderson, T., Petranker, R., Dinh-Williams, L. A., Hui, K., & Hapke, E. (2020). Microdosing psychedelics: Demographics, practices, and psychiatric comorbidities. Journal of Psychopharmacology, 34(6), 612-622. DOI: https://doi.org/10.1177%2F0269881120908004) 2019 Survey: Self-Rated Effectiveness of Microdosing With Psychedelics for Mental and Physical Health Problems Among Microdosers(Hutten, N. R. P. W., Mason, N. L., Dolder, P. C., & Kuypers, K. P. C. (2019). Self-Rated Effectiveness of Microdosing With Psychedelics for Mental and Physical Health Problems Among Microdosers. Frontiers in psychiatry, 10, 672. https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2019.00672/full)WEB | getsetset.comIG | @getsetsetYouTube | youtube.com/@getsetset Get full access to SetSet with April Pride at aprilpride.substack.com/subscribe

Robert (Bob) Wilson is an Associate Professor of Psychology at Georgia Tech. We talk about his tutorial paper (w/ Anne Collins) on computational modelling, and some of his recent work on detecting phishing.BJKS Podcast is a podcast about neuroscience, psychology, and anything vaguely related, hosted by Benjamin James Kuper-Smith.Support the show: https://geni.us/bjks-patreonTimestamps0:00:00: Bob's strange path through computational cognitive neuroscience0:07:37: Phishing: a computational model with real-life applications0:25:46: Start discussing Bob's paper 10 simple rules for computational modeling of behavioral data0:32:15: Rule 0: Why even do computational modelling?0:46:24: Rules 1 & 2: Design a good experiment & Design a good model1:02:51: Rule 3: Simulate!1:05:48: Rules 4 & 5: Parameter estimation and recovery1:18:28: Rule 6: Model recovery1:25:55: Rules 7 & 8: Collect data and validate the model1:33:15: Rule 9: Latent variable analysis1:36:24: Rule 10: Report your results1:37:46: Computational modelling and the open science movement1:40:17: A book or paper more people should read1:43:35: Something Bob wishes he'd learnt sooner1:47:18: Advice for PhD students/postdocsPodcast linksWebsite: https://geni.us/bjks-podTwitter: https://geni.us/bjks-pod-twtRobert's linksWebsite: https://geni.us/wilson-webGoogle Scholar: https://geni.us/wilson-scholarTwitter: https://geni.us/wilson-twtBen's linksWebsite: https://geni.us/bjks-webGoogle Scholar: https://geni.us/bjks-scholarTwitter: https://geni.us/bjks-twtReferencesEpisodes w/ Paul Smaldino: https://geni.us/bjks-smaldinohttps://geni.us/bjks-smaldino_2Bechara, Damasio, Damasio, & Anderson (1994). Insensitivity to future consequences following damage to human prefrontal cortex. Cognition.Feng, Wang, Zarnescu & Wilson (2021). The dynamics of explore–exploit decisions reveal a signal-to-noise mechanism for random exploration. Scientific Reports.Grilli, ... & Wilson (2021). Is this phishing? Older age is associated with greater difficulty discriminating between safe and malicious emails. The Journals of Gerontology: Series B.Hakim, Ebner, ... & Wilson (2021). The Phishing Email Suspicion Test (PEST) a lab-based task for evaluating the cognitive mechanisms of phishing detection. Behavior research methods.Harootonian, Ekstrom & Wilson (2022). Combination and competition between path integration and landmark navigation in the estimation of heading direction. PLoS Computational Biology.Hopfield (1982). Neural networks and physical systems with emergent collective computational abilities. PNAS.MacKay (2003). Information theory, inference and learning algorithms.Miller, Eugene & Pribram (1960). Plans and the Structure of Behaviour.Sweis, Abram, Schmidt, Seeland, MacDonald III, Thomas, & Redish (2018). Sensitivity to “sunk costs” in mice, rats, and humans. Science.Walasek & Stewart (2021). You cannot accurately estimate an individual's loss aversion using an accept–reject task. Decision.Wilson & Collins (2019). Ten simple rules for the computational modeling of behavioral data. Elife.

In this episode of the Epigenetics Podcast, we talked with Yadira Soto-Feliciano from MIT about her work on the Menin-MLL complex and the effect of small molecules on its stability in leukemia. We explore the pivotal moments that led her to cancer biology during her graduate studies, where her work included ground-breaking research on the role of the plant homeodomain Finger protein-6 (PHF-6) in leukemia. This work bridged the realms of chromatin accessibility, transcription factors, and cancer cell lineage, providing critical evidence for the concept of lineage plasticity in cancer biology—a topic that has gained significant traction in recent years. Dr. Soto-Feliciano discusses how advances in techniques like CRISPR and ChIP-sequencing have shaped her research, enabling deeper insights into the mechanisms underlying cancer cell identity. As our discussion transitions, Dr. Soto-Feliciano shares her experience in David Allis's lab, illustrating how the collaboration across diverse scientific disciplines enhanced her understanding of chromatin biology and generated significant insights into the mechanics of epigenetic regulation. Highlighting a recent 2023 publication, we unpack her findings related to the conserved molecular switch between MLL1 and MLL3 complexes. These discoveries revealed how the application of small-molecule inhibitors of the menin-MLL interaction can alter gene expression and affect leukemia cells' responses to treatments. We also touch on the operational dynamics within her lab at MIT, established during challenging times marked by the pandemic. Yadira is dedicated to fostering a collaborative and respectful environment among her team, comprised of PhD candidates and research technicians, all sharing a commitment to unraveling the complexities of chromatin regulation. She emphasizes the significance of understanding chromatin scaffold proteins and their role in regulating gene expression and genome organization.   References Soto-Feliciano, Y. M., Bartlebaugh, J. M. E., Liu, Y., Sánchez-Rivera, F. J., Bhutkar, A., Weintraub, A. S., Buenrostro, J. D., Cheng, C. S., Regev, A., Jacks, T. E., Young, R. A., & Hemann, M. T. (2017). PHF6 regulates phenotypic plasticity through chromatin organization within lineage-specific genes. Genes & development, 31(10), 973–989. https://doi.org/10.1101/gad.295857.117 Soto-Feliciano, Y. M., Sánchez-Rivera, F. J., Perner, F., Barrows, D. W., Kastenhuber, E. R., Ho, Y. J., Carroll, T., Xiong, Y., Anand, D., Soshnev, A. A., Gates, L., Beytagh, M. C., Cheon, D., Gu, S., Liu, X. S., Krivtsov, A. V., Meneses, M., de Stanchina, E., Stone, R. M., Armstrong, S. A., … Allis, C. D. (2023). A Molecular Switch between Mammalian MLL Complexes Dictates Response to Menin-MLL Inhibition. Cancer discovery, 13(1), 146–169. https://doi.org/10.1158/2159-8290.CD-22-0416 Zhu, C., Soto-Feliciano, Y. M., Morris, J. P., Huang, C. H., Koche, R. P., Ho, Y. J., Banito, A., Chen, C. W., Shroff, A., Tian, S., Livshits, G., Chen, C. C., Fennell, M., Armstrong, S. A., Allis, C. D., Tschaharganeh, D. F., & Lowe, S. W. (2023). MLL3 regulates the CDKN2A tumor suppressor locus in liver cancer. eLife, 12, e80854. https://doi.org/10.7554/eLife.80854   Related Episodes MLL Proteins in Mixed-Lineage Leukemia (Yali Dou) Targeting COMPASS to Cure Childhood Leukemia (Ali Shilatifard)   Contact Epigenetics Podcast on Instagram Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com

Recent scientific research suggests that jujube seeds, a traditional Chinese medicine, may hold the key to natural brain regeneration. Studies have shown that consuming jujube seeds can improve cognitive function, reduce inflammation in the brain, and even reverse some of the damage caused by neurodegenerative diseases. While more research is needed to fully understand the mechanisms behind these effects, jujube seeds offer a promising natural approach to promoting brain health and potentially reversing age-related cognitive decline. #jujubesseds #dementia #brainhealth Umeda Tomohiro, Sakai Ayumi, Uekado Rumi, Shigemori Keiko, Nakajima Ryota, Yamana Kei, Tomiyama Takami (2024) Simply crushed Zizyphi spinosi semen prevents neurodegenerative diseases and reverses age-related cognitive decline in mice eLife 13:RP100737 https://doi.org/10.7554/eLife.100737.1 Ziziphus jujuba, jujube seeds, brain regeneration, neurogenesis, neuroprotection, cognitive function, memory impairment, Alzheimer's disease, dementia, Parkinson's disease, oxidative stress, inflammation, neuroinflammation, antioxidant, polyphenol, triterpenoid, flavonoid, animal model, mouse model, in vitro study, cell culture, neuronal differentiation, synaptic plasticity, neurotrophic factor, traditional Chinese medicine --- Support this podcast: https://podcasters.spotify.com/pod/show/ralph-turchiano/support

La relation entre le stress et le blanchiment des cheveux est un sujet qui a intrigué les chercheurs pendant des décennies. Si l'idée que le stress puisse accélérer le grisonnement est souvent évoquée, des études scientifiques récentes ont permis de mieux comprendre les mécanismes biologiques impliqués et de confirmer cette hypothèse. Le Processus de Pigmentation des Cheveux La couleur des cheveux est déterminée par la présence de mélanine, un pigment produit par les mélanocytes situés dans les follicules pileux. Avec l'âge, la production de mélanine diminue naturellement, entraînant le blanchiment progressif des cheveux. Cependant, des facteurs externes, y compris le stress, peuvent influencer ce processus. Le Rôle du Stress Des études sur des modèles animaux et des recherches récentes sur des humains suggèrent que le stress peut effectivement accélérer la dépigmentation des cheveux. En 2020, une étude publiée dans *Nature* a montré que le stress aigu active le système nerveux sympathique, qui libère de la noradrénaline dans les follicules pileux. Cette libération soudaine provoque l'épuisement des cellules souches mélanocytaires, essentielles pour la production de mélanine. Une fois ces cellules souches épuisées, elles ne peuvent plus régénérer la pigmentation, ce qui entraîne le blanchiment des cheveux . Des expériences menées sur des souris ont également mis en évidence ce lien. Les chercheurs ont soumis les souris à un stress intense et ont observé une perte rapide de la pigmentation des poils. Les résultats ont révélé que la libération excessive de noradrénaline provoquait la migration et l'épuisement des cellules souches responsables de la couleur, confirmant un lien direct entre le stress et le grisonnement accéléré . Mécanismes Biologiques Le mécanisme par lequel le stress entraîne le blanchiment des cheveux est principalement lié à l'activation du système nerveux sympathique et à la libération d'hormones du stress, telles que l'adrénaline et le cortisol. Une autre étude, publiée dans *Cell*, a montré que le stress chronique pouvait également affecter la régénération des cellules souches dans d'autres parties du corps, soulignant l'impact global du stress sur la biologie cellulaire . Stress et Blanchiment Réversible ? Une question importante est de savoir si les effets du stress sur le grisonnement sont réversibles. Bien que les effets du stress aigu puissent conduire à un épuisement permanent des cellules souches mélanocytaires, les chercheurs ont observé que dans certains cas de stress temporaire ou modéré, les cheveux peuvent retrouver leur couleur normale une fois que le stress est réduit. Une étude publiée dans *eLife* en 2021 a démontré que certains cheveux gris redevenaient pigmentés après une réduction significative du stress chez les participants, suggérant que le processus pourrait être, dans certains cas, partiellement réversible . Conclusion En résumé, les preuves scientifiques indiquent clairement que le stress peut accélérer le processus de blanchiment des cheveux en perturbant les cellules souches responsables de la production de mélanine. Le mécanisme principal implique la libération de noradrénaline et d'autres hormones du stress, qui épuisent ces cellules souches. Toutefois, dans certains cas, la réduction du stress peut potentiellement inverser partiellement le processus. Ces découvertes soulignent l'impact profond que le stress peut avoir non seulement sur la santé mentale, mais aussi sur la biologie cellulaire et l'apparence physique. Hébergé par Acast. Visitez acast.com/privacy pour plus d'informations.

先週に続き慶應義塾大学理工学部教授の牛場潤一さんをゲストに迎えて『「よく学びよく遊べ」の意味～後続のために果たすべき役割とは』をテーマにトークセッションを行います。＜目次＞00:35　フリクションとイノベーション04:58　歴史ある分野での新しさの受け容れかた12:57　受け容れる側のマインドが試される20:53　内なる動機の追求がもたらす圧倒的な結果24:58　「よく学びよく遊べ」の意味30:48　自分の方法で世界を見るレンズを持ち続ける38:22　リスナーへの『問い』＜ゲストプロフィール＞牛場 潤一（ウシバ・ジュンイチ）慶應義塾大学理工学部教授。1978年7月8日生まれ、東京都出身。2001年、慶應義塾大学理工学部卒。2004年に博士（工学）を取得。同年、生命情報学科に助手として着任。以降、専任講師（'07〜）、准教授（'12〜）、基礎科学・基盤工学インスティテュート（KiPAS）主任研究員（'14〜'18）を経て、2022年より教授。研究成果活用企業株式会社LIFESCAPES（'19〜）の代表取締役社長を兼務。The BCI Research Award 2019, 2017, 2013, 2012, 2010 Top 10-12 Nominees、文部科学省「平成27年度若手科学者賞(ブレイン・マシン・インターフェースによる神経医療研究）ほか、受賞多数。 脳が本来持つ「やわらかさ」に着目し、一人ひとりが豊かで人間らしい日々を過ごすためのテクノロジーの創造を目指し、脳と機械を接続して身体運動を補助するブレイン・マシン・インターフェース技術（BMI）の基礎研究から応用研究、医療機器開発までを、一気通貫で取り組んでいる。 近年の代表的な論文に、”Beta rhythmicity in human motor cortex reflects neural population coupling that modulates subsequent finger coordination stability (Communications Biology 2022)”、” Spatially bivariate EEG-neurofeedback can manipulate interhemispheric inhibition (Elife 2022)”、” Thirty-minute motor imagery exercise aided by EEG sensorimotor rhythm neurofeedback enhances morphing of sensorimotor cortices; A double-blind sham-controlled study (Cerebral Cortex 2022)”など。◼︎プラダアンバサダーの永野芽郁と、魚類学者のさかなクンが、海に住む生き物について、またその生き物たちが抱えている問題について語り合う「PRADA OCEAN PODCAST」配信中！https://sbwl.to/40xPc2b

慶應義塾大学理工学部教授の牛場潤一さんをゲストに迎えて『「やわらかい」脳の再配線〜麻痺を治せる世界に向けて』をテーマにトークセッションを行います。＜目次＞00:35　オープニングトーク01:52　人間の脳の可塑性08:36　BMI＝ブレイン・マシン・インターフェース12:41 「やわらかい」脳の大きな可能性17:11　麻痺を治すための脳の再配線　23:41　世界のBMI研究最前線27:05　BMI研究を続ける難しさ30:28　BMIのイメージを変えた学生の声34:23　BMI研究に至るまでのキャリア37:46　コンテクストデザインとの共通意識＜ゲストプロフィール＞牛場 潤一（ウシバ・ジュンイチ）慶應義塾大学理工学部教授。1978年7月8日生まれ、東京都出身。2001年、慶應義塾大学理工学部卒。2004年に博士（工学）を取得。同年、生命情報学科に助手として着任。以降、専任講師（'07〜）、准教授（'12〜）、基礎科学・基盤工学インスティテュート（KiPAS）主任研究員（'14〜'18）を経て、2022年より教授。研究成果活用企業株式会社LIFESCAPES（'19〜）の代表取締役社長を兼務。The BCI Research Award 2019, 2017, 2013, 2012, 2010 Top 10-12 Nominees、文部科学省「平成27年度若手科学者賞(ブレイン・マシン・インターフェースによる神経医療研究）ほか、受賞多数。 脳が本来持つ「やわらかさ」に着目し、一人ひとりが豊かで人間らしい日々を過ごすためのテクノロジーの創造を目指し、脳と機械を接続して身体運動を補助するブレイン・マシン・インターフェース技術（BMI）の基礎研究から応用研究、医療機器開発までを、一気通貫で取り組んでいる。 近年の代表的な論文に、”Beta rhythmicity in human motor cortex reflects neural population coupling that modulates subsequent finger coordination stability (Communications Biology 2022)”、” Spatially bivariate EEG-neurofeedback can manipulate interhemispheric inhibition (Elife 2022)”、” Thirty-minute motor imagery exercise aided by EEG sensorimotor rhythm neurofeedback enhances morphing of sensorimotor cortices; A double-blind sham-controlled study (Cerebral Cortex 2022)”など。

In this episode of the Epigenetics Podcast, we talked with Carl Wu from John's Hopkins University about his work on nucleosome remodeling, histone variants, and the role of single-molecule imaging in gene regulation. Our discussion starts with Carl Wu sharing his first significant milestones, a paper in "Cell" and the serendipitous discovery of DNA hypersensitive sites, which transformed our understanding of chromatin accessibility and its implications for gene regulation. As we delve into Dr. Wu's specific areas of research, he elaborates on the biochemistry of nucleosome remodeling and the intricate role of chromatin remodeling enzymes like NURF. We discuss how these enzymes employ ATP hydrolysis to reposition nucleosomes, making DNA accessible for transcription. He then explains the collaborative relationship between chromatin remodelers and transcription factors, showcasing the fascinating interplay that governs gene expression and regulatory mechanisms. The conversation takes a deeper turn as we explore Carl Wu's groundbreaking studies on histone variants, particularly H2AZ. He elucidates the role of SWR1 in facilitating the exchange between H2A and H2AZ in nucleosome arrays. The high-resolution structural insights garnered from recent studies reveal how the enzyme mediates histone eviction and insertion with remarkable precision, providing a clearer picture of chromatin dynamics at a molecular level.   References Wu, C., Bingham, P. M., Livak, K. J., Holmgren, R., & Elgin, S. C. (1979). The chromatin structure of specific genes: I. Evidence for higher order domains of defined DNA sequence. Cell, 16(4), 797–806. https://doi.org/10.1016/0092-8674(79)90095-3 Wu, C., Wong, Y. C., & Elgin, S. C. (1979). The chromatin structure of specific genes: II. Disruption of chromatin structure during gene activity. Cell, 16(4), 807–814. https://doi.org/10.1016/0092-8674(79)90096-5 Wu C. (1980). The 5' ends of Drosophila heat shock genes in chromatin are hypersensitive to DNase I. Nature, 286(5776), 854–860. https://doi.org/10.1038/286854a0 Wu, C., Wilson, S., Walker, B., Dawid, I., Paisley, T., Zimarino, V., & Ueda, H. (1987). Purification and properties of Drosophila heat shock activator protein. Science (New York, N.Y.), 238(4831), 1247–1253. https://doi.org/10.1126/science.3685975 Mizuguchi, G., Shen, X., Landry, J., Wu, W. H., Sen, S., & Wu, C. (2004). ATP-driven exchange of histone H2AZ variant catalyzed by SWR1 chromatin remodeling complex. Science (New York, N.Y.), 303(5656), 343–348. https://doi.org/10.1126/science.1090701 Kim, J. M., Visanpattanasin, P., Jou, V., Liu, S., Tang, X., Zheng, Q., Li, K. Y., Snedeker, J., Lavis, L. D., Lionnet, T., & Wu, C. (2021). Single-molecule imaging of chromatin remodelers reveals role of ATPase in promoting fast kinetics of target search and dissociation from chromatin. eLife, 10, e69387. https://doi.org/10.7554/eLife.69387   Related Episodes Multiple challenges of ATAC-Seq, Points to Consider (Yuan Xue) Pioneer Transcription Factors and Their Influence on Chromatin Structure (Ken Zaret) ATAC-Seq, scATAC-Seq and Chromatin Dynamics in Single-Cells (Jason Buenrostro)   Contact Epigenetics Podcast on X Epigenetics Podcast on Instagram Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Epigenetics Podcast on Threads Active Motif on X Active Motif on LinkedIn Email: podcast@activemotif.com

Ist Stress eigentlich schlechter für uns, wenn wir glauben, dass er schlecht ist? Wir alle kennen das Gefühl gestresst zu sein und welche negativen Folgen Stress mit sich ziehen kann. Doch inwieweit spielt unsere Sichtweise auf den Stress eine Rolle in der Stresswahrnehmung? Diesen Fragen gehen Sinja und Boris in dieser Folge auf den Grund. Wie gefällt dir Verstehen, fühlen, glücklich sein? Erzähle es uns hier.Hintergründe und Studien:Keller, A., Litzelman, K., Wisk, L., Maddox, T., Cheng, E., Creswell, P., & Witt, W. (2012). Does the perception that stress affects health matter? The association with health and mortality.. Health psychology : official journal of the Division of Health Psychology, American Psychological Association, 31 5, 677-84 Link zur Studie Nabi, H., Kivimäki, M., Batty, G., Shipley, M., Britton, A., Brunner, E., Vahtera, J., Lemogne, C., Elbaz, A., & Singh‐Manoux, A. (2013). Increased risk of coronary heart disease among individuals reporting adverse impact of stress on their health: the Whitehall II prospective cohort study.. European heart journal, 34 34, 2697-705 Link zur Studie Dhabhar FS, Malarkey WB, Neri E, McEwen BS. Stress-induced redistribution of immune cells--from barracks to boulevards to battlefields: a tale of three hormones--Curt Richter Award winner. Psychoneuroendocrinology. 2012 Sep;37(9):1345-68. doi: 10.1016/j.psyneuen.2012.05.008. Epub 2012 Jun 22. PMID: 22727761; PMCID: PMC3412918. Link zur Studie Kirby, E., Muroy, S., Sun, W., Covarrubias, D., Leong, M., Barchas, L., & Kaufer, D. (2013). Acute stress enhances adult rat hippocampal neurogenesis and activation of newborn neurons via secreted astrocytic FGF2. eLife, 2 Link zur Studie Ell, S.W., Cosley, B. & McCoy, S.K. When bad stress goes good: increased threat reactivity predicts improved category learning performance. Psychon Bull Rev 18, 96–102 (2011). Link zur Studie Crum, A., Salovey, P., & Achor, S. (2013). Rethinking stress: the role of mindsets in determining the stress response.. Journal of personality and social psychology, 104 4, 716-33 . Link zur Studie Crum, A., Santoro, E., Handley-Miner, I., Smith, E., Evans, K., Moraveji, N., Achor, S., & Salovey, P. (2023). Evaluation of the "rethink stress" mindset intervention: A metacognitive approach to changing mindsets.. Journal of experimental psychology. General. Link zur Studie Unsere allgemeinen Datenschutzrichtlinien finden Sie unter https://art19.com/privacy. Die Datenschutzrichtlinien für Kalifornien sind unter https://art19.com/privacy#do-not-sell-my-info abrufbar.

Russ Ewell's first son was born while he and his wife Gail lived in the Washington, DC area. The doctor said to him “Congratulations! You have a son.” Next the doctor said, “He has down syndrome…”. In time, they moved to Silicon Valley. Russ and his wife, Gail's, journey as parents of two children with special needs led them to start: Spiritual Resource Ministry at Bay Area Christian Church, which offers individuals with special needs and their families the ability to thrive spiritually alongside their neurotypical peers in every area of the church, which they may not otherwise be able to do. E-Sports and E-Life are free, inclusive community programs across the Bay Area enabling kids with special needs to participate in sports and activities alongside their neurotypical peers. Hope Technology School is a private, non-profit, non-sectarian K-12 school, started by Russ and Gail. HTS serves neurotypical kids and kids with special needs from all backgrounds and operates independently of BACC. HTS is regularly recognized as one of the best private schools in the Bay Area. Digital Scribbler, a company Russ founded which develops assistive tech tools for individuals with disabilities. They also have developed a Special Needs Ministry Manual that you can download at the Bay Area Christian Church website for free. (https://bacc.cc/small-groups/srm/manual/) Listen as we unpack Russ's Ministry, family life journey, and the tools to help you develop another great ministry in your area! Contact with Russ at: https://russewell.com/ _______________________________ Looking for a new student ministry resource? You can read my book “Burn Up Not Out: A Student Ministry Fire Builder's Guidebook” here: https://amzn.to/3PtBTIy Listen to more episodes from the Youth Worker On Fire Podcast here: https://bit.ly/3saDyYq _______________________________ EPISODE CREDITS Email us at: youthworkeronfire@gmail.com Hosted by: Doug Edwards Theme Song: "The One and Only" by The 808 : Listen to more at https://bit.ly/3FTYIAJ Intro/Outro Voiceover: Michael Helms : https://www.youtube.com/@MichaelTheSoundGuy  Edited by: Secret Roots Music House

In this episode, we continue our discussion of replications. We talk about how to analyze replication studies, which studies are worth replicating, and what is the status of replications in other scientific disciplines.    Shownotes Mack, R. W. (1951). The Need for Replication Research in Sociology. American Sociological Review, 16(1), 93–94. https://doi.org/10.2307/2087978 Smith, N. C. (1970). Replication studies: A neglected aspect of psychological research. American Psychologist, 25(10), 970–975. https://doi.org/10.1037/h0029774 Sidman, M. (1960). Tactics of Scientific Research: Evaluating Experimental Data in Psychology (New edition). Cambridge Center for Behavioral. Ebersole, C. R., Mathur, M. B., Baranski, E., Bart-Plange, D.-J., Buttrick, N. R., Chartier, C. R., Corker, K. S., Corley, M., Hartshorne, J. K., IJzerman, H., Lazarević, L. B., Rabagliati, H., Ropovik, I., Aczel, B., Aeschbach, L. F., Andrighetto, L., Arnal, J. D., Arrow, H., Babincak, P., … Nosek, B. A. (2020). Many Labs 5: Testing Pre-Data-Collection Peer Review as an Intervention to Increase Replicability. Advances in Methods and Practices in Psychological Science. https://doi.org/10.1177/2515245920958687 Isager, P. M., van Aert, R. C. M., Bahník, Š., Brandt, M. J., DeSoto, K. A., Giner-Sorolla, R., Krueger, J. I., Perugini, M., Ropovik, I., van 't Veer, A. E., Vranka, M., & Lakens, D. (2023). Deciding what to replicate: A decision model for replication study selection under resource and knowledge constraints. Psychological Methods, 28(2), 438–451. https://doi.org/10.1037/met0000438 Aldhous, P. (2011). Journal rejects studies contradicting precognition. New Scientist. https://www.newscientist.com/article/dn20447-journal-rejects-studies-contradicting-precognition/ Stanley, D. J., & Spence, J. R. (2014). Expectations for Replications: Are Yours Realistic? Perspectives on Psychological Science, 9(3), 305–318. https://doi.org/10.1177/1745691614528518 Simonsohn, U. (2015). Small telescopes: Detectability and the evaluation of replication results. Psychological Science, 26(5), 559–569. https://doi.org/10.1177/0956797614567341 Nosek, B.A., Errington, T.M. (2017) Reproducibility in Cancer Biology: Making sense of replications. eLife 6:e23383. https://doi.org/10.7554/eLife.23383      

LaQuita Mason, a Healthcare Administrator with a Master's Degree in Healthcare Administration concentrating in Long-Term Care, symbolizes excellence in the healthcare business. With over 18 years of broad experience, including a decade of duty in the United States Air Force, her path is defined by extraordinary accomplishments and a profound dedication to excellent care. Her […]

Killer whales are likely ramming boats because they're bored and having funSeveral years ago a small population of killer whales living off the coast of Spain began attacking boats, particularly sailboats, damaging some severely and even sinking a handful. While social media speculation has suggested whale rage as a cause, an international team of killer whale experts recently published a report suggesting the behaviour is not aggression, but is instead an example of these giant social creatures just playing and having fun with a toy. We speak with two contributors to the report: John Ford, research scientist emeritus at the Pacific Biological Station with Fisheries & Oceans Canada, and Renaud de Stephanis, the president of Spanish conservation group CIRCE.4,000-year-old Egyptian skull shows signs of possible surgery for brain cancerResearchers studying the history of cancer in human history recently hit the jackpot. In a collection of human remains at the University of Cambridge they found two skulls from Egypt, both thousands of years old, that show signs of advanced cancer. One of those skulls bore cut marks around the lesions. Lead study author and University of Santiago de Compostela professor Edgard Camarós said that regardless of whether these cuts were made as attempts at treatment or a post-mortem investigation, they show off the sophisticated medical knowledge of ancient Egyptians — and can also help better understand the evolution of cancer.This study was published in Frontiers in Medicine.Gorillas' tiny penises and low sperm count can help us understand infertility in humansGorillas are the biggest of the great apes, but their reproductive anatomy is diminutive. The males have small penises and testes, and low sperm quality. A new genetic analysis, published in the scientific journal eLife, identified the mutations that are responsible for male gorillas' peculiar fertility. Vincent Lynch, an associate professor of biological sciences at the State University of New York at Buffalo, said these findings can help us better understand the genes responsible for lower sperm quality in humans.1Illuminating plumes of hot magma in the Earth's mantle with earthquake seismic dataTo understand the source of the magma fueling volcanic eruptions, scientists are using another significant geological event: earthquakes. The seismic waves that earthquakes send through our planet can shine a light on the chimneys of magma that connect the core of the Earth through the mantle to the surface. Karin Sigloch, a professor of geophysics at CNRS — France's National Centre for Scientific Research, is part of an international effort to deploy seismic sensors throughout the oceans to illuminate the mantle plumes. Their research from recent observations in the Indian Ocean around Réunion Island was in Nature Geoscience. It's intelligence all the way down: How cells, tissues and organs have their own smartsWe tend to think of collective intelligence as something we see among animals that work cooperatively to solve problems, like in an ant colony, a school of fish or flock of birds. But biologist Michael Levin, from Harvard and Tufts' universities, thinks collective intelligence also extends to functions within the cell, all the way up to networks of cells, tissues and even organs. He suggests evolution has granted simpler biological layers in living systems the ability to flexibly solve problems. In a recent paper in Communications Biology, he argues we can harness these lower level problem-solving capabilities to make significant advances in regenerative medicine, and treating aging and disease.  

Dr. Daniele Marinazzo is a full professor in the department of data analysis at the University of Ghent, in Belgium. For over a decade he has been showing us what further information and insight we may extract from brain imaging data - from EEG and MEG to fMRI. He is technically a statistical physicist, but in reality, he is a network neuroscientist and data modeler who is constantly pushing the envelope. In this podcast he discusses some recent papers that go into how we might be able to improve the impact and relevance of new findings and models through careful benchmarking and well considered experimental design. He talks about his desire to move from correlation to causation in functional connectivity studies, he discusses granger causality, as well as moving from pairwise correlation to multivariate correlation. Furthermore, he delves into the limits of hemodynamics - limits that may be pushed back to a degree, as suggested by his compelling work showing that hemodynamic response function, which varies over space, may be estimated on a voxel-wise basis using resting state data alone. His work in estimating and mapping the Excitation/Inhibition ratio in the brain by using gamma frequency coherence as a signature was also discussed. This has potentially profound clinical and research applications. Lastly, his collaborative work with the European Human Brain Project towards the creation of the useful website, called ebrains (https://www.ebrains.eu), was discussed, which serves as a repository and tool for exploring shared data and code, as well as providing a user-friendly encapsulation of the project's collective effort. It is an all-around fun, eye-opening discussion featuring an outstanding scientist who is not only deep in the trenches of network modelling, but also a strong proponent of open science and constant engagement across disciplines. Episode producers: Omer Faruk Gulban Alfie Wearn Stephania Assimopoulos Referenced Papers: Mika Rubinov. Circular and unified analysis in network neuroscience. eLife. 2023; 12:e79559. Doi: 10.7554/eLife.79559   Reid AT, et al. Advancing functional connectivity research from association to causation. Nat Neurosci. 2019 Nov;22(11):1751-1760. Doi: 10.1038/s41593-019-0510-4.   Valdes-Sosa PA et al. Effective connectivity: Influence, causality and biophysical modelling. Neuroimage. 2009; 58(2): 339-361. Doi: 10.1016/j.neuroimage.2011.03.058.   Wu GR, et al. A blind deconvolution approach to recover effective connectivity brain networks from resting state fMRI data. Medical Image Analysis. 2013; 17(3):365-374. Doi: 10.1016/j.media.2013.01.003.

In this episode of the Epigenetics Podcast, we talked with Upasna Sharma from UC Santa Cruz about her work a number of interesting projects on H2A.Z and telomeres, the impact of paternal diet on offspring metabolism, and the role of small RNAs in sperm. In this interview Upasna Sharma discusses her work on the study of the paternal diet's impact on offspring metabolism. She reveals the discovery of small non-coding RNAs, particularly tRNA fragments, in mature mammalian sperm that may carry epigenetic information to the next generation. She explains the specific alterations in tRNA fragment levels in response to a low-protein diet and the connections found between tRNA fragments and metabolic status. Dr. Sharma further explains the degradation and stabilization of tRNA fragments in cells and the processes involved in their regulation. She shares their observation of tRNA fragment abundance in epididymal sperm, despite the sperm being transcriptionally silent at that time. This leads to a discussion on the role of the epididymis in the reprogramming of small RNA profiles and the transportation of tRNA fragments through extracellular vesicles. The conversation then shifts towards the potential mechanism of how environmental information could be transmitted to sperm and the observed changes in small RNAs in response to a low-protein diet. Dr. Sharma discusses the manipulation of small RNAs in embryos and mouse embryonic stem cells, revealing their role in regulating specific sets of genes during early development. However, the exact mechanisms that link these early changes to metabolic phenotypes are still being explored. References Sharma, U., Conine, C. C., Shea, J. M., Boskovic, A., Derr, A. G., Bing, X. Y., Belleannee, C., Kucukural, A., Serra, R. W., Sun, F., Song, L., Carone, B. R., Ricci, E. P., Li, X. Z., Fauquier, L., Moore, M. J., Sullivan, R., Mello, C. C., Garber, M., & Rando, O. J. (2016). Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals. Science (New York, N.Y.), 351(6271), 391–396. https://doi.org/10.1126/science.aad6780 Sharma, U., Sun, F., Conine, C. C., Reichholf, B., Kukreja, S., Herzog, V. A., Ameres, S. L., & Rando, O. J. (2018). Small RNAs Are Trafficked from the Epididymis to Developing Mammalian Sperm. Developmental cell, 46(4), 481–494.e6. https://doi.org/10.1016/j.devcel.2018.06.023 Rinaldi, V. D., Donnard, E., Gellatly, K., Rasmussen, M., Kucukural, A., Yukselen, O., Garber, M., Sharma, U., & Rando, O. J. (2020). An atlas of cell types in the mouse epididymis and vas deferens. eLife, 9, e55474. https://doi.org/10.7554/eLife.55474   Related Episodes The Epigenetics of Human Sperm Cells (Sarah Kimmins) Transgenerational Inheritance and Evolution of Epimutations (Peter Sarkies) The Role of Small RNAs in Transgenerational Inheritance in C. elegans (Oded Rechavi)   Contact Epigenetics Podcast on X Epigenetics Podcast on Instagram Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Epigenetics Podcast on Threads Active Motif on X Active Motif on LinkedIn Email: podcast@activemotif.com

Maria Guerreiro ORCID: 0000-0003-0010-6895 Maria Guerreiro is the Head of Partnership Development at Dryad. She is an open science enthusiast who enjoys working collaboratively with researchers and other stakeholders in scholarly communication to drive positive change. She is Head of Partnership Development at Dryad, where she leads the partnership recruitment programme with publishers, scholarly societies and research institutions. Prior to Dryad, Maria spent a decade in journal publishing, primarily at eLife, where she was Head of Journal Development and worked directly with scientists, research organizations and funding agencies in the biomedical and life sciences in initiatives to drive growth, foster community engagement and promote best practices in peer review and scientific publishing. Sarah Lippincott ORCID: 0000-0002-5700-5844 Sarah Lippincott is a librarian and library consultant with a decade of experience supporting open access, digital scholarship, and scholarly communications through strategic planning, research, service design, facilitation, and communications work. As Head of Community Engagement at Dryad, Sarah works with institutions, funders, and researchers to increase awareness of and engagement with data sharing and data reuse. She received her MLS from University of North Carolina-Chapel Hill and prior to joining Dryad, she worked in a variety of roles within and adjacent to libraries. Sarah started her career as the founding Program Director for the Library Publishing Coalition and went on to coordinate assessment, user experience, and strategic planning activities for a major research library; led strategic consulting services for a digital services agency specializing in open source web development for the cultural heritage sector; and consulted on projects for the Educopia Institute, the Next Generation Library Publishing project (NGLP), the Library Publishing Coalition, Candid, the Preservation of Electronic Government Information (PEGI) Project, the Association of Research Libraries (ARL), and the Digital Public Library of America (DPLA). Find more podcast episodes here: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://access2perspectives.pubpub.org/podcast⁠⁠⁠⁠⁠⁠⁠⁠⁠ Host:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Dr Jo Havemann⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠, ORCID iD ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠0000-0002-6157-1494 ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Editing: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Ebuka Ezeike⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Music:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Alex Lustig⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠, produced by⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Kitty Kat ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ License:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Attribution 4.0 International (CC BY 4.0)   ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ At Access 2 Perspectives, we guide you in your complete research workflow toward state-of-the-art research practices and in full compliance with funding and publishing requirements. Leverage your research projects to higher efficiency and increased collaboration opportunities while fostering your explorative spirit and joy. Website: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://access2perspectives.pubpub.org⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ --- Send in a voice message: https://podcasters.spotify.com/pod/show/access2perspectives/message

The title of this episode says it all. Today, we're going to be dealing with the fate of Antioch once Ptolemy III comes strolling over. Plus, we'll finally get to move Seleucus around a bit and see some divine justice being doled out by the weather system... Sources for this episode: Bevan, E. R. (1902), The House of Seleucus (Vol. I). London: Edward Arthur (eBook). Grainger, J. D. (2014), The Rise of the Seleukid Empire (323- 223 BCE), Seleukos I to Seleukos III. Barnsley: Pen & Sword Books Ltd. (eBook). Rosenberg, A. M., Rausser, S., Ren, J., Mosharov, E. V., Sturm, G., Odgon, R. T., Patel, P., Soni, R. K., Lacefield, C., Tobin, D. J., Paus, R. and Picard, M. (2021), Quantitative mapping of human hair greying and reversal in relation to life stress. eLife 10: e67437. Watson, J. S. (1853), on Attalus (date unknown), Justinus: Epitome of Pompeius Trogus' Philippic Histories (online) (Accessed 23/10/2023). Author unknown, Wikipedia (date unknown), Xanthippus (Spartan commander) (online) (Accessed 21/11/2023).

In this episode I talk about a surgery I just had. That I'm hoping will change my life for the BETTER. This episode was recorded in “real time” the morning of my surgery (my thoughts getting ready to go to the hospital and emotions) and (almost) 24 hours after my surgery (how I'm feeling, what I had done, mishaps, pain etc). I am planning a part 2 to this 6-12 months later to let you know if the surgery was a success for me and my health journey. #surgery #health #journey #reproductivehealth #mylife #mystory #real #reallife #mylifestory

Chromosomal recombination is an essential part of the life cycle of all sexually reproducing organisms. Yet, the system is complex, involving hundreds to thousands of proteins and RNAs. It also involves DNA repair pathways, which are themselves incredibly complex. The newest available information on recombination tells us it is mutagenic, meaning that recombination erodes the very places where recombination happens. How did such a system arise by chance? Can we assume the recombination rate has always been the same? What happens when a new allele arises in the protein that controls recombination? What is the mutation burden caused by this important system? Finally, how does this affect the creation-evolution debate? Links and notes: 15 Questions for evolutionists, #8 How did sex originate? Geeking out about DNA damage repair, June 2023. Grey et al. 2018 PRDM9, a driver of the genetic map, PLoS Genet 14(8):e1007479. Altemose et al. 2017 A map of human PRDM9 binding provides evidence for novel behaviors of PRDM9 and other zinc-finger proteins in meiosis, eLife 6:e28383. Robert Carter gets everything wrong?, creation.com, 10 Jul 2021. Hussin et al. 2011 Age-dependent recombination rates in human pedigrees, PloS Genetics 7(9):e1002251. Wang et al. 2012 Genome-wide single-cell analysis of recombination activity and de novo mutation rates in human sperm, Cell 150(2):402–12. African origins and the rise of carnivory, creation.com,19 Dec 2020. Hinch, A.G. et al., The landscape of recombination in African Americans, Nature 476:170–177, 2011. Hinch et al. 2023 Meiotic DNA breaks drive multifaceted mutagenesis in the human germ line, Science 382:eadh2531.

Chromosomal recombination is an essential part of the life cycle of all sexually reproducing organisms. Yet, the system is complex, involving hundreds to thousands of proteins and RNAs. It also involves DNA repair pathways, which are themselves incredibly complex. The newest available information on recombination tells us it is mutagenic, meaning that recombination erodes the very places where recombination happens. How did such a system arise by chance? Can we assume the recombination rate has always been the same? What happens when a new allele arises in the protein that controls recombination? What is the mutation burden caused by this important system? Finally, how does this affect the creation-evolution debate? Links and notes: 15 Questions for evolutionists, #8 How did sex originate? Geeking out about DNA damage repair, June 2023. Grey et al. 2018 PRDM9, a driver of the genetic map, PLoS Genet 14(8):e1007479. Altemose et al. 2017 A map of human PRDM9 binding provides evidence for novel behaviors of PRDM9 and other zinc-finger proteins in meiosis, eLife 6:e28383. Robert Carter gets everything wrong?, creation.com, 10 Jul 2021. Hussin et al. 2011 Age-dependent recombination rates in human pedigrees, PloS Genetics 7(9):e1002251. Wang et al. 2012 Genome-wide single-cell analysis of recombination activity and de novo mutation rates in human sperm, Cell 150(2):402–12. African origins and the rise of carnivory, creation.com,19 Dec 2020. Hinch, A.G. et al., The landscape of recombination in African Americans, Nature 476:170–177, 2011. Hinch et al. 2023 Meiotic DNA breaks drive multifaceted mutagenesis in the human germ line, Science 382:eadh2531.

“Science can only progress if others are able to read and build off of what has been learned in the past.” Jessica Polka shares this insight and many more in this conversation with LSP about the current state of scientific publishing. As the executive director of ASAPbio, an organization battling the slowing of the sharing of scientific knowledge, she's played a key role in catalyzing change when it comes to how and when scientific articles are shared. We dive into the White House memo calling for all scientific papers to be open access by 2025, what some of her key concerns are for the space, and that explosive eLife announcement about preprints. You won't want to miss this great conversation! Links for Jessica:Twitter: https://twitter.com/jessicapolkaLinkedIn: https://www.linkedin.com/in/jessicapolka/ASAPbio: www.asapbio.org

In this episode of the Epigenetics Podcast, we caught up with Sheila Teves from the University of British Columbia to talk about her work on the inheritance of transcriptional memory by mitotic bookmarking. Early in her research career, Sheila Teves focused on the impact of nucleosomes on torsional stress and gene regulation. She also highlights the development of a genome-wide approach to measure torsional stress and its relationship to nucleosome dynamics and RNA polymerase regulation. The conversation then shifts to her focus on transcriptional memory and mitotic bookmarking during her postdoc in the Tijan lab. She explores the concept of mitotic bookmarking, whereby certain transcription factors remain bound to their target sites during mitosis, facilitating efficient reactivation of transcription after cell division. She discusses her findings on the behavior of transcription factors on mitotic chromosomes, challenging the notion that they are excluded during mitosis. She also discusses the differences in binding behavior between the general transcription factor TBP and other transcription factors. Finally, the effect of formaldehyde fixation on the potential to find transcription factors bound to mitotic chromosomes is discussed.   References Teves, S., Henikoff, S. Transcription-generated torsional stress destabilizes nucleosomes. Nat Struct Mol Biol 21, 88–94 (2014). https://doi.org/10.1038/nsmb.2723 Sheila S Teves, Luye An, Anders S Hansen, Liangqi Xie, Xavier Darzacq, Robert Tjian (2016) A dynamic mode of mitotic bookmarking by transcription factors eLife 5:e22280. https://doi.org/10.7554/eLife.22280 Sheila S Teves, Luye An, Aarohi Bhargava-Shah, Liangqi Xie, Xavier Darzacq, Robert Tjian (2018) A stable mode of bookmarking by TBP recruits RNA polymerase II to mitotic chromosomes eLife 7:e35621. https://doi.org/10.7554/eLife.35621 Kwan, J. Z. J., Nguyen, T. F., Uzozie, A. C., Budzynski, M. A., Cui, J., Lee, J. M. C., Van Petegem, F., Lange, P. F., & Teves, S. S. (2023). RNA Polymerase II transcription independent of TBP in murine embryonic stem cells. eLife, 12, e83810. https://doi.org/10.7554/eLife.83810 Price, R. M., Budzyński, M. A., Shen, J., Mitchell, J. E., Kwan, J. Z. J., & Teves, S. S. (2023). Heat shock transcription factors demonstrate a distinct mode of interaction with mitotic chromosomes. Nucleic acids research, 51(10), 5040–5055. https://doi.org/10.1093/nar/gkad304   Related Episodes In Vivo Nucleosome Structure and Dynamics (Srinivas Ramachandran) From Nucleosome Structure to Function (Karolin Luger) Structural Analysis of Nucleosomes During Transcription (Lucas Farnung)   Contact Epigenetics Podcast on Twitter Epigenetics Podcast on Instagram Epigenetics Podcast on Mastodon Active Motif on Twitter Active Motif on LinkedIn Email: podcast@activemotif.com

This month, how an extinct marine mammal made its haemoglobin work in the cold, how does learning compassion change the shape of the human brain, women publishing cautiously, how populations evolve to social distance in disease conditions, and can biochemical clocks accurately track ageing in children? Join Dr Chris Smith for a look at some of eLife's latest leading papers... Get the references and the transcripts for this programme from the Naked Scientists website

Presenting a sham treatment as personalised increases the placebo effect in a randomised controlled trial. Sandra DA, Olson JA, Langer EJ, et al. eLife. 2023;12:e84691. doi:10.7554/eLife.84691 Due to copyright laws, unless the article is open source we cannot legally post the PDF on the website for the world to download at will. Brought to you by CSMi – https://www.humacnorm.com/ptinquest Learn more about/Buy Erik's courses – The Science PT Support us on the Patreons! Music for PT Inquest: “The Science of Selling Yourself Short” by Less Than Jake Used by Permission Other Music by Kevin MacLeod – incompetech.com: MidRoll Promo – Mining by Moonlight

A fascinating new look at treating periodontal disease using macrophages differently. Katrina Sanders, RDH takes a look at work coming from Kings College in London related to using telocytes as a regulator of M1 vs M2 macrophages! Resources: More Fast Facts: https://www.ataleoftwohygienists.com/fast-facts/ Katrina Sanders Website: https://www.katrinasanders.com  Katrina Sanders Instagram:   https://www.instagram.com/thedentalwinegenist/  Jing Zhao, Anahid A Birjandi, Mohi Ahmed, Yushi Redhead, Jose Villagomez Olea, Paul Sharpe (2022). Telocytes regulate macrophages in periodontal disease. Published in eLife https://doi.org/10.7554/eLife.72128    

This week Matthew speaks with Jenny Tung, McArthur fellow and the director of the Max Planck Institute for Evolutionary Anthropology.They start out by discussing the mutual benefits that molecular biologists and behavioral ecologists can gain from bringing their methods and frameworks together. They discuss two examples of the power of that synergy from Jenny's work as a co-director of the Amboseli Baboon Research Project: (1) unraveling the hybridization history of the population and the behavioral impacts of hybrid ancestry and (2) measuring "biological" age and its predictors. They close by discussing Jenny's new role as director of MPI for Evolutionary Anthropology.Papers Relevant to this Week's episode:Hybridization in the Amboseli population:Vilgalys, T. P., Fogel, A. S., Anderson, J. A., Mututua, R. S., Warutere, J. K., Siodi, I. L. I., ... & Tung, J. (2022). Selection against admixture and gene regulatory divergence in a long-term primate field study. Science, 377(6606), 635-641.Biological aging in baboons:Anderson, J. A., Johnston, R. A., Lea, A. J., Campos, F. A., Voyles, T. N., Akinyi, M. Y., ... & Tung, J. (2021). High social status males experience accelerated epigenetic aging in wild baboons. Elife, 10, e66128.Credits: The Animal Behavior Podcast is created by a team of animal behavior researchers and audio professionals. Come meet us here! We receive production support from the Cornell Broadcast studio directed by Bert Odom-Reed, and financial support from the Animal Behavior Society.

Tracklist: 00:00 | 00. Intro 01:35 | 01. Atmozfears & Devin Wild - Long Way Home 04:49 | 02. Audiotricz, Ecstatic featuring MERYLL - In Our Heads 07:40 | 03. Wildstylez featuring E-Life and Noah Jacobs - One 10:39 | 04. Bass Modulators - Sun Goes Down 13:10 | 05. Da Tweekaz & Frontliner - Never Far 16:37 | 06. Headhunterz Feat. TATU - Colors 18:47 | 07. Festuca - Pressure Waves 21:22 | 08. Adronity & High Level ft. TNYA - Dream Of Reality 24:25 | 09. Coone - Dance With My Demons 27:15 | 10. Phuture Noize featuring Daimy Lotus - Thru the Smoke 30:30 | 11. Rebelion and Atilax - Rebels Of Shutdown (Shutdown Festival 2023 Anthem) 34:41 | 12. Bass X Machina & REVIVE ft. Ava Silver - Transcend 38:30 | 13. Boray - Get Loose 41:00 | 14. B-Front, MNO and DV8 - Echoes 44:46 | 15. E-Force & Frequencerz - Men Of Steel (Adaro & Level One Remix) 48:16 | 16. E-Force & Luna - Kicks Like This 51:24 | 17. Sefa - 1527 54:30 | 18. Angerfist - What Happened 56:52 | 19. The Prophet & Dr. Peacock - Killing No More

In this episode of the Epigenetics Podcast, we talked with Mary Gehring from MIT about her work on transgenerational inheritance and epigenetic imprinting in plants. Mary Gehring and her team are focusing on plant epigenetics and genetic imprinting in plants, studying DNA methylation in Arabidopsis. They have found significant differences in DNA methylation between the embryo and endosperm of plants, particularly in relation to imprinted genes. She also discusses their work on hydroxymethylcytosine (5-hmC) in Arabidopsis and the challenges of detecting and studying this epigenetic modification. Next, we discuss the regulatory circuit involving ROS1, a DNA glycosylase involved in demethylation, and its role in maintaining epigenetic homeostasis. The interview concludes with a discussion of CUT&RUN, which the lab has adapted for use in plants. Due to its low input requirements this method has been valuable in studying various plant tissues and has influenced Mary Gehring's research on imprinting in Arabidopsis endosperm.   References Gehring, M., Bubb, K. L., & Henikoff, S. (2009). Extensive demethylation of repetitive elements during seed development underlies gene imprinting. Science (New York, N.Y.), 324(5933), 1447–1451. https://doi.org/10.1126/science.1171609 Pignatta, D., Erdmann, R. M., Scheer, E., Picard, C. L., Bell, G. W., & Gehring, M. (2014). Natural epigenetic polymorphisms lead to intraspecific variation in Arabidopsis gene imprinting. eLife, 3, e03198. https://doi.org/10.7554/eLife.03198 Klosinska, M., Picard, C. L., & Gehring, M. (2016). Conserved imprinting associated with unique epigenetic signatures in the Arabidopsis genus. Nature plants, 2, 16145. https://doi.org/10.1038/nplants.2016.145 Zheng, X. Y., & Gehring, M. (2019). Low-input chromatin profiling in Arabidopsis endosperm using CUT&RUN. Plant reproduction, 32(1), 63–75. https://doi.org/10.1007/s00497-018-00358-1   Related Episodes The Role of Small RNAs in Transgenerational Inheritance in C. elegans (Oded Rechavi) Epigenetic Influence on Memory Formation and Inheritance (Isabelle Mansuy) The Epigenetics of Human Sperm Cells (Sarah Kimmins)   Contact Epigenetics Podcast on Twitter Epigenetics Podcast on Instagram Epigenetics Podcast on Mastodon Active Motif on Twitter Active Motif on LinkedIn Email: podcast@activemotif.com

This month we look at a method to raise the bar on the quality and trustworthiness of information shared over social media networks, how fish running a fever heal from infection faster, what miniature bat backpacks can reveal about the eating and hunting habits of our flying mammalian cousins, how kingfishers come by their plumage patterns, and the evolution of spider venom genes. Join Dr Chris Smith for a look inside the science at eLife... Get the references and the transcripts for this programme from the Naked Scientists website

The Be More Today Show is back with a special episode looking at the Athletic brain. Check out my conversation with fellow Brown Alumna and life-long athlete Dr. Allison Brager. Dr. Allison Brager is the Chief Science Officer of the John F. Kennedy Special Warfare Center and School. She is the recipient of two National Research Service Awards from the National Institutes of Health and a National Academies of Sciences Fellowship to study physiological resiliency in extreme environments. Dr. Brager's work spans from clinical drug trials to applied field studies with elite athletes, combat divers, and Special Forces in some of the most austere places on earth to include Antarctica. In 2020, Dr. Brager underwent astronaut assessment & selection at NASA.   She sits on advisory boards for the NCAA, NATO, Special Operations Command, the Office of the Army Surgeon General, and the federal government. She is the recipient of two presidential Meritorious Service Medals and a Joint Commendation Medal for her clinical and research expertise during the COVID-19 pandemic and the War on Terrorism. Dr. Brager has > 40 peer-reviewed publications in flagship journals to include Science, eLife, Journal of Neuroscience, and Neuropsychopharmacology and is author of Meathead: Unraveling the Athletic Brain. She holds an Sc.B in Psychology from Brown University and a Ph.D in Physiology from Kent State University. www.bemoretoday.com --- Send in a voice message: https://podcasters.spotify.com/pod/show/bemoretoday/message Support this podcast: https://podcasters.spotify.com/pod/show/bemoretoday/support

In this episode of the Epigenetics Podcast, we caught up with Luciano Di Croce from the Center of Genomic Regulation in Barcelona to talk about his work on epigenetic landscapes in cancer. The Di Croce Lab focuses on the Polycomb Complex and its influence on diseases like cancer. Luciano Di Croce started out his research career investigating the oncogenic transcription factor PML-RAR. They could show that in leukemic cells knockdown of SUZ12, a key component of Polycomb repressive complex 2 (PRC2), reverts not only histone modification but also induces DNA de-methylation of PML-RAR target genes. More recently the team focused on two other Polycomb related proteins Zrf1 and PHF19 and were able to characterize some of their functions in gene targeting in different disease and developmental contexts.   References Di Croce, L., Raker, V. A., Corsaro, M., Fazi, F., Fanelli, M., Faretta, M., Fuks, F., Lo Coco, F., Kouzarides, T., Nervi, C., Minucci, S., & Pelicci, P. G. (2002). Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor. Science (New York, N.Y.), 295(5557), 1079–1082. https://doi.org/10.1126/science.1065173 Richly, H., Rocha-Viegas, L., Ribeiro, J. D., Demajo, S., Gundem, G., Lopez-Bigas, N., Nakagawa, T., Rospert, S., Ito, T., & Di Croce, L. (2010). Transcriptional activation of polycomb-repressed genes by ZRF1. Nature, 468(7327), 1124–1128. https://doi.org/10.1038/nature09574 Jain, P., Ballare, C., Blanco, E., Vizan, P., & Di Croce, L. (2020). PHF19 mediated regulation of proliferation and invasiveness in prostate cancer cells. eLife, 9, e51373. https://doi.org/10.7554/eLife.51373   Related Episodes Oncohistones as Drivers of Pediatric Brain Tumors (Nada Jabado) Transcription and Polycomb in Inheritance and Disease (Danny Reinberg) Targeting COMPASS to Cure Childhood Leukemia (Ali Shilatifard)   Contact Epigenetics Podcast on Twitter Epigenetics Podcast on Instagram Epigenetics Podcast on Mastodon Active Motif on Twitter Active Motif on LinkedIn Email: podcast@activemotif.com

Today, you'll learn about mushrooms that can eat asteroids to make space soil, how our thoughts affect us as we microdose psychedelics, and efforts to 3D print organs like kidneys and lungs!Hungry mushrooms.Fungi Could Make Soil From Asteroids and Homes on Mars by Madeleine Gregoryhttps://www.discovermagazine.com/the-sciences/fungi-could-make-soil-from-asteroids-and-homes-on-marsMaking Soil for Space Habitats by Seeding Asteroids with Fungi by Jane Shevtsovhttps://www.nasa.gov/directorates/spacetech/niac/2021_Phase_I/Making_Soil_for_Space_Habitats/Could Future Homes on the Moon and Mars Be Made of Fungi? by Frank Tavareshttps://www.nasa.gov/feature/ames/myco-architectureFuture Space Travel Might Require Mushrooms by Nick Hildenhttps://www.scientificamerican.com/article/space-travels-most-surprising-future-ingredient-mushrooms/Far out thoughts.Citizen Scientists Show Placebo Effect May Explain Benefits of Microdosing by Ryan O'harehttps://www.imperial.ac.uk/news/216134/citizen-scientists-show-placebo-effect-explain/Self-Blinding Citizen Science to Explore Psychedelic Microdosing by Balázs Szigeti, et al.https://doi.org/10.7554/eLife.62878What to Know About Microdosing LSD by Medical News Todayhttps://www.medicalnewstoday.com/articles/microdosing-lsdPsychedelic Microdosing Benefits and Challenges: An Empirical Codebook by Thomas Anderson, et al.https://doi.org/10.1186/s12954-019-0308-4A different kind of printer.“When we'll be able to 3D-print organs and who will be able to afford them” by Kristen Rogershttps://www.cnn.com/2022/06/10/health/3d-printed-organs-bioprinting-life-itself-wellness-scn/index.html“Advanced Polymers for Three-Dimensional (3D) Organ Bioprinting” by Xiaohong Wang.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952999/#:~:text=Three%2Ddimensional%20(3D)%20organ%20bioprinting%20is%20the%20utilization%20of,7%2C8%2C9%5DFollow Curiosity Daily on your favorite podcast app to get smarter with Calli and Nate — for free! Still curious? Get exclusive science shows, nature documentaries, and more real-life entertainment on discovery+! Go to https://discoveryplus.com/curiosity to start your 7-day free trial. discovery+ is currently only available for US subscribers.Find episode transcripts here: https://curiosity-daily-4e53644e.simplecast.com/episodes/asteroid-eating-fungi-psychedelicmaybe-printing-organs