Podcasts about ELife

This week on the show, we're have our sights set on healthy aging. What would it mean to be able to live to 80, 90 or 100 with our cognitive abilities intact and able to maintain an independent lifestyle right to the end of our days? We're joined by Beth Mormino and Anthony Wagner who lead the Stanford Aging and Memory Study, which recruits cognitively healthy older adults to understand what makes their brains particularly resilient — and how more of us could join them in living the dream of healthy aging.Learn MoreStanford Aging and Memory Study (SAMS)Stanford Memory LabMormino LabFurther ReadingAlzheimer's 'resilience signature' predicts who will develop dementia—and how fast (Knight Initiative for Brain Resilience, 2025)Latest Alzheimer's lab tests focus on memory loss, not brain plaques (NPR, 2025)ReferencesTrelle, A. N., ... & Wagner, A. D. (2020). Hippocampal and cortical mechanisms at retrieval explain variability in episodic remembering in older adults. eLife, 9:e55335. doi: 10.7554/eLife.55335 PDF | PMID:32469308Trelle, A. N., ..., Wagner, A. D., Mormino, E. C., & Wilson, E. N. (2025). Plasma Aβ42/Aβ40 is sensitive to early cerebral amyloid accumulation and predicts risk of cognitive decline across the Alzheimer's disease spectrum. Alzheimer's & Dementia, 21:e14442. PDF | PMID:39713875Sheng, J., ..., Mormino, E., & Wagner, A. D. (submitted). Top-down attention and Alzheimer's pathology impact cortical selectivity during learning, influencing episodic memory in older adults.  PreprintEpisode CreditsThis episode was produced by Michael Osborne at 14th Street Studios, with sound design by Morgan Honaker. Our logo is by Aimee Garza. The show is hosted by Nicholas Weiler at Stanford's Wu Tsai Neurosciences Institute and supported in part by the Knight Iniative for Brain Resilience.Get in touchWe want to hear from your neurons! Email us at at neuronspodcast@stanford.edu if you'd be willing to help out with some listener rSend us a text!Thanks for listening! If you're enjoying our show, please take a moment to give us a review on your podcast app of choice and share this episode with your friends. That's how we grow as a show and bring the stories of the frontiers of neuroscience to a wider audience. Learn more about the Wu Tsai Neurosciences Institute at Stanford and follow us on Twitter, Facebook, and LinkedIn.

Pour écouter mon podcast Choses à Savoir Culture Générale:Apple Podcast:https://podcasts.apple.com/fr/podcast/choses-%C3%A0-savoir-culture-g%C3%A9n%C3%A9rale/id1048372492Spotify:https://open.spotify.com/show/3AL8eKPHOUINc6usVSbRo3?si=e794067703c14028----------------------------La température corporelle humaine "normale", établie à 37 °C par le médecin allemand Carl Wunderlich en 1851, n'est aujourd'hui plus d'actualité. Plusieurs études récentes confirment que cette valeur a progressivement diminué au fil des deux derniers siècles. En moyenne, les hommes modernes ont vu leur température chuter de 0,59 °C et les femmes de 0,32 °C. Ainsi aujourd'hui la température moyenne est aujourd'hui autour de 36,6 °C, voire un peu moins. Cette évolution, bien que surprenante à première vue, s'explique scientifiquement par des facteurs biologiques et environnementaux.L'une des hypothèses principales repose sur la baisse généralisée des niveaux d'inflammation chronique dans la population. En effet, au XIXe siècle, les infections bactériennes étaient beaucoup plus fréquentes (tuberculose, syphilis, maladies dentaires, etc.). Elles provoquaient des inflammations durables, stimulant le système immunitaire et augmentant la température de base du corps. Or, avec l'amélioration des conditions sanitaires, l'accès aux antibiotiques, à la vaccination et à une meilleure hygiène, le fardeau infectieux a nettement diminué.Une étude emblématique publiée en 2020 dans la revue eLife par le Pr. Julie Parsonnet et son équipe de l'université de Stanford a confirmé ce phénomène. En analysant plus de 677 000 données de température corporelle collectées aux États-Unis entre 1862 et 2017, les chercheurs ont observé une baisse constante de la température moyenne, décennie après décennie. Selon eux, la diminution de l'inflammation systémique et de l'activité du système immunitaire expliquerait en grande partie cette évolution.Mais ce n'est pas tout : notre mode de vie moderne joue aussi un rôle essentiel. Les êtres humains vivent aujourd'hui dans des environnements thermiquement plus stables et confortables, grâce au chauffage central et à la climatisation. Cette stabilité thermique réduit le besoin pour le corps de réguler activement sa température en produisant de la chaleur – un processus métabolique coûteux en énergie. Moins sollicité, le métabolisme de base ralentit, ce qui peut entraîner une baisse légère mais mesurable de la température corporelle.D'autres facteurs sont évoqués, comme la réduction de l'activité physique, l'évolution de la masse corporelle moyenne, ou encore les modifications de l'alimentation. L'ensemble de ces changements contribue à redéfinir la "norme" physiologique humaine.En somme, la baisse de notre température corporelle est le reflet d'une transformation profonde de notre santé, de notre environnement et de notre mode de vie. Elle ne témoigne pas d'un dysfonctionnement, mais plutôt d'une adaptation biologique à un monde moins hostile et plus maîtrisé. Hébergé par Acast. Visitez acast.com/privacy pour plus d'informations.

La température corporelle humaine "normale", établie à 37 °C par le médecin allemand Carl Wunderlich en 1851, n'est aujourd'hui plus d'actualité. Plusieurs études récentes confirment que cette valeur a progressivement diminué au fil des deux derniers siècles. En moyenne, les hommes modernes ont vu leur température chuter de 0,59 °C et les femmes de 0,32 °C. Ainsi aujourd'hui la température moyenne est aujourd'hui autour de 36,6 °C, voire un peu moins. Cette évolution, bien que surprenante à première vue, s'explique scientifiquement par des facteurs biologiques et environnementaux.L'une des hypothèses principales repose sur la baisse généralisée des niveaux d'inflammation chronique dans la population. En effet, au XIXe siècle, les infections bactériennes étaient beaucoup plus fréquentes (tuberculose, syphilis, maladies dentaires, etc.). Elles provoquaient des inflammations durables, stimulant le système immunitaire et augmentant la température de base du corps. Or, avec l'amélioration des conditions sanitaires, l'accès aux antibiotiques, à la vaccination et à une meilleure hygiène, le fardeau infectieux a nettement diminué.Une étude emblématique publiée en 2020 dans la revue eLife par le Pr. Julie Parsonnet et son équipe de l'université de Stanford a confirmé ce phénomène. En analysant plus de 677 000 données de température corporelle collectées aux États-Unis entre 1862 et 2017, les chercheurs ont observé une baisse constante de la température moyenne, décennie après décennie. Selon eux, la diminution de l'inflammation systémique et de l'activité du système immunitaire expliquerait en grande partie cette évolution.Mais ce n'est pas tout : notre mode de vie moderne joue aussi un rôle essentiel. Les êtres humains vivent aujourd'hui dans des environnements thermiquement plus stables et confortables, grâce au chauffage central et à la climatisation. Cette stabilité thermique réduit le besoin pour le corps de réguler activement sa température en produisant de la chaleur – un processus métabolique coûteux en énergie. Moins sollicité, le métabolisme de base ralentit, ce qui peut entraîner une baisse légère mais mesurable de la température corporelle.D'autres facteurs sont évoqués, comme la réduction de l'activité physique, l'évolution de la masse corporelle moyenne, ou encore les modifications de l'alimentation. L'ensemble de ces changements contribue à redéfinir la "norme" physiologique humaine.En somme, la baisse de notre température corporelle est le reflet d'une transformation profonde de notre santé, de notre environnement et de notre mode de vie. Elle ne témoigne pas d'un dysfonctionnement, mais plutôt d'une adaptation biologique à un monde moins hostile et plus maîtrisé. Hébergé par Acast. Visitez acast.com/privacy pour plus d'informations.

What is the impact of an extra year at school on the brain? Also, how poison dart frogs come by their toxins, using movies to track the developing infant nervous system, the insect-spread bacterial plant parasite that is a mastermind of matchmaking, and a new cancer tool to link disease with the best drugs. Chris Smith takes a look at some of the most powerful papers out this month in eLife... Get the references and the transcripts for this programme from the Naked Scientists website

Disability Ministry Series 'Autism and the Church' with Pastor Russ Ewell Welcome back to the Podcast.  Today we have Russ Ewell, lead pastor of Bay Area Christian Church and father of two children with special needs as our guest.  As a father and an advocate in the special needs community he understands the need for creating inclusive environments for our children.  As a Pastor, he and his wife have launched a free, step-by-step guide to help leaders begin or grow this ministry at their church.  He knows that many Pastors are interested in serving the special needs community, but lack the resources to make this a reality and is meeting the need with this resource. In addition, Russ has create E-Sports and E-Life which are inclusive community programs enabling kids with special needs to participate in sports and activities alongside their peers. As we approaching Autism awareness month, Russ brings a fresh perspective of what is possible for individuals special needs and the greater community.  Let's listen in as we join Russ. BIO Russ Ewell is Executive Minister of the Bay Area Christian Church. A minister for more than 40 years, Russ's teaching is rooted in providing hope for those turned off by tradition, and infused with vision for building the transformative church for which the 21st century public hungers.   Contacts: BACC Website: bacc.cc The Spiritual Resource Ministry will shortly release a manual to assist leaders in establishing ministries for individuals with special needs: http://bacc.cc/srm E-Sports.org https://e-sports.org/ E-life.org https://e-life.org/ Social Media: https://www.instagram.com/the.bacc/ https://www.facebook.com/the.bacc     For a family raising a child with special needs, life can be difficult. There are many storms to weather and struggles to address, and we often feel isolated and alone due to the nature of our circumstances. Families have a need to connect and find resources, a need to be encouraged, and a need for hope as we walk down what can be a very hard road at times. Hope on the Hard Road Special Needs Podcast was created for this purpose. Our vision is to grow a thriving community, where families with children of all ages with special needs can feel connected, be encouraged, and find hope for the road ahead. Connect with Us: If you enjoy this podcast please share us with others and be sure to follow us so won't miss an episode. We'd love to hear from you so please leave us a comment or rating and connect with us on social media or on our website. Email us: info@hopeonthehardroad.org Website: https://hopeonthehardroad.org/ Instagram: https://www.instagram.com/hopeonthehardroad/ Facebook: https://www.facebook.com/hopeonthehardroad/ Facebook Group: https://www.facebook.com/groups/2621447987943459 Free Youtube Resource Library: https://www.youtube.com/playlist?list=PLsSAfvTkSy87X-fEqtVR2qvo7w9UQBuxz  

Time for some semi-structured yet informal musings from god's gayest student-of-the-world, Sarah Schauer! This is Schauer Thoughts, a punderful new pod for left and right brainers! So sit back, relax, and let your frontal lobe mull over a little hopecore. Stop putting off those doctors appointments and go to https://Zocdoc.com/SCHAUER to find and instantly book a top-rated doctor today. Sources: SchizophrenicReads IG - https://www.instagram.com/schizophrenicreads/reel/DCFcALFSZ0-/ Wired to Wonder - Todd Kashdan https://greatergood.berkeley.edu/article/item/wired_to_wonder#:~:text=Part%20of%20the%20answer%20is%20whether%20a,and%20experiences%20are%20transferred%20into%20long%2Dterm%20memory. Abramson, A. (2024, January 1). Hope as the antidote. Monitor on Psychology, 55(1). https://www.apa.org/monitor/2024/01/trends-hope-greater-meaning-life Wamsley EJ. How the brain constructs dreams. Elife. 2020 Jun 8;9:e58874. doi: 10.7554/eLife.58874. PMID: 32508304; PMCID: PMC7279884. How Emotions Are Made - Lisa Feldman Barrett Between Us: How Cultures Create Emotions - Batja Mesquita Follow Sarah: @SarahSchauer To watch the podcast on YouTube: https://www.youtube.com/@sarahschauer3764 Learn more about your ad choices. Visit podcastchoices.com/adchoices

Die Themen in den Wissensnachrichten: +++ Omega-3-Fettsäuren könnten Altersveränderungen bremsen +++ Altsteinzeit-Menschen hatten wohl schon Piercings +++ Koffein schützt vermutlich Mate-Pflanze +++**********Weiterführende Quellen zu dieser Folge:Individual and additive effects of vitamin D, omega-3 and exercise on DNA methylation clocks of biological aging in older adults from the DO-HEALTH trial, Nature Aging, 03.02.2025Probable Use of Labrets Among the Mid Upper Paleolithic Pavlovian Peoples of Central Europe, Journal of Paleolithic Archaeology, 23.01.2025Yerba mate (Ilex paraguariensis) genome provides new insights into convergent evolution of caffeine biosynthesis, Elife, 08.01.2025Bioaccumulation of microplastics in decedent human brains, Nature Medicine, 03.02.2025Local chemical heterogeneity enabled superior zero thermal expansion in nonstoichiometric pyrochlore magnets, National Science Review, 17.12.2024Alle Quellen findet ihr hier.**********Ihr könnt uns auch auf diesen Kanälen folgen: TikTok auf&ab , TikTok wie_geht und Instagram .

Reintroducing Hawaii's sacred crow to the wildThe world's most endangered crow, the Hawaiian crow or or ʻalalā, is making tentative steps towards a comeback. After going extinct in the wild, only 120 birds remain in captivity, in two facilities operated by the San Diego Zoo. Over the years, researchers have attempted reintroductions in the bird's native habitat on the Big Island of Hawaii, but those efforts have all been unsuccessful. Recently, the team tried something different - reintroducing the birds to a different island than their native home. The initial release happened in October and so far, the team, including Bryce Masuda, has high hopes and positive signs from their latest attempt.Lasers tell us about the pterosaur's unique tailThe great flying reptiles of the dawn of the age of dinosaurs, the pterosaurs, took flight with delicate but flexible internal tail structure that allowed it to work like a kite. Scientists used recently developed technology to enable them to see a lattice-like structure in the soft tissue in the early pterosaur soft tissue that was otherwise invisible to the naked eye. Natalia Jagielska, a paleontologist at the Lyme Regis Museum in Dorset, England, said their kite-like tail vane would have stood upright and could have functioned as a display and to help them in flight. The study was published in the eLife journal, Evolutionary Biology. How gophers help re-seed volcanic landscape with lifeAfter Mt. St. Helens exploded in 1980 it left a shattered, ash-covered, barren landscape behind. But the one-time reintroduction of gophers to one area led to a remarkably fast recovery of plants and other fauna. Forty-years later, changes to the environment are still being documented by  Dr. Mia Maltz, assistant professor of Microbial Ecology and Soil Earth at the University of Connecticut, and her team. They published their research in the journal Frontiers in Microbiomes.Desert ants' magnetic navigationDesert ants that navigate the endless sands of the Sahara use the Earth's magnetic field to find their way, which is not unusual. But unlike other animals like birds and turtles they don't appear to have an internal compass that aligns north and south. Instead they are unique in that they  use a more subtle cue – the polarity of the magnetic field. A study looking at this led by Dr. Pauline Fleischmann, a post-doctoral researcher at the University of Oldenburg in Germany  was published in the journal Current Biology. Celestial body mysteries: dark comets and meteorites from young asteroid families The thousands of small celestial bodies in our solar system are now a bit less mysterious, thanks to several recent discoveries. One group of astronomers have traced back the origins of 84 per cent of all known meteorites that have pummeled Earth to just a few young asteroid families in the asteroid belt. Michaël Marsset, from the European Southern Observatory in Chile, said collisions in the asteroid belt create a collisional cascade that produces fragments, some of which end up raining down on Earth as meteorites. Two of their papers were published in the journal Nature and a third in Astronomy & Astrophysics. Another group of astronomers have identified two populations of stealthy dark comets that are something in between a comet and an asteroid. They've found fourteen of these objects whose orbital motion is comet-like, but which lack a visible tail like regular comets. Davide Farnocchia, a navigation engineer at NASA's Jet Propulsion Lab, said they've found two types of these unusual solar system bodies: larger ones in an elliptical orbit out to Jupiter and smaller ones in orbit around Earth. Their study was published in the journal PNAS.

Aujourd'hui, nous parlons de sommeil, mais plus particulièrement d'insomnie et des impacts d'un mauvais sommeil sur notre santé physique et psychologique. En particulier, nous discuterons du fait qu'il existe des solutions pour traiter l'insomnie, mais aussi pour améliorer son sommeil et ses habitudes, que le fait de prendre soin de son sommeil peut avoir des répercussions beaucoup plus grandes que ce qu'on peut imaginer, et qu'il ne faut pas attendre pour adresser les problèmes s'il y en a.Envoyez-nous vos suggestions de sujets pour nos prochains épisodes de podcast. Vous avez de bonnes idées ou il y a des sujets en lien avec la santé métabolique et la perte de poids qui vous intéressent? Écrivez-nous à info@solutions-santé.ca.   Nous recevons Maude Bouchard, qui détient un doctorat en neuropsychologie. Maude cumule plus de 15 ans d'expertise dans le domaine du sommeil. Elle a fait ses études de premier et de deuxième cycle à l'Université de Montréal. Elle a publié ses travaux dans des revues scientifiques réputées telles que Sleep et eLife et a donné de nombreuses conférences nationales et internationales au fil des ans. Animée par une passion pour l'enseignement et le transfert de connaissances, Dre Maude Bouchard a été professeure adjointe au City College de New York et chargée de cours à l'Université de Montréal et à l'Université du Québec à Chicoutimi. Maude Bouchard occupe actuellement le poste de directrice de la recherche et du développement chez HALEO. Expérience personnelle d'Èvelyne avec l'insomnieLesimpacts d'un mauvais sommeil sur notre santé physique et psychologiqueLes impacts positifs d'avoir un meilleur sommeil sur notre humeur et nos émotions, la gestion du stress, nos capacités cognitives et motrices, notre jugement et même notre manière de s'alimenter et notre impulsivité.La thérapie cognitive-comportementale de l'insomnie LA TCC-I comme première ligne de traitement, ce que c'est, les principes derrière et les résultats que ça peut amener sur le sommeil, mais aussi les symptômes d'anxiété, de dépression et la prise de médicaments pour dormir.L'astuce de la semaine donnée par Maude Il faut écouter l'épisode pour la connaître!Les messages clés de l'épisode sont : Il existe des solutions pour traiter l'insomnie, mais aussi pour améliorer son sommeil et ses habitudes. Le fait de prendre soin de son sommeil peut avoir des répercussions beaucoup plus grandes que ce qu'on peut imaginer.Il y a une relation bidirectionnelle entre le sommeil et la santé physique, dont le poids, et la santé mentale. Il faut parler de son sommeil avec son médecin ou les professionnels de la santé dans notre équipe de soin et ne pas attendre pour adresser les problèmes s'il y en a.Pour en savoir plus sur les programmes d'Haleo, pour faire le questionnaire de dépistage ou pour prendre RV :https://questionnaire.haleoclinic.com/home/fr-caRéseaux sociaux : https://www.linkedin.com/company/haleosleep et https://www.facebook.com/haleo.ca et https://www.instagram.com/haleo.clinic/Hébergé par Ausha. Visitez ausha.co/politique-de-confidentialite pour plus d'informations.

In this episode of the Epigenetics Podcast, we talked with Vijay Ramani from the Gladstone Institute to talk about his work on Single-Molecule Adenine Methylated Oligonucleosome Sequencing Assay (SAMOSA). Our discussion starts with Vijay Ramani's impactful contributions to the field during his time in Jay Shendure's lab, where he worked on several innovative methods, including RNA proximity ligation. This project was conceived during his graduate studies, aiming to adapt techniques from DNA research to investigate RNA structures—a largely unexplored area at the time. We delved into the nuances of his experiences in graduate school, emphasizing how critical it was to have mentors who provided room for creativity and autonomy in experimental design. Dr. Ramani then shares insights about his foray into developing more refined methodologies, such as in-situ DNA Hi-C, a revolutionary protocol tailored for three-dimensional genomic mapping. He explained the rationale behind his projects, comparing the outcomes with contemporaneous advancements in methods like Micro-C. The discussion highlighted the importance of understanding enzyme bias in chromatin studies and the need for meticulous experimental design to ensure the validity of biological interpretations. We further explored exciting advancements in single-cell genomics, specifically Ramani's work on developing sci-Hi-C. This innovative technique leverages combinatorial indexing to allow high-resolution mapping of chromatin architecture at the single-cell level, a significant leap forward in understanding the complexities of gene regulation. As we progress, Ramani detailed his transition from graduate student to independent investigator starting his own lab. He elaborated on the challenges and excitements associated with establishing his research focus in chromatin structure and function using advanced sequencing technologies. Employing various strategies, including the innovative SAMOSA assay, his research seeks to elucidate the mechanisms by which chromatin structure influences transcriptional regulation. We also discussed the heterogeneity of chromatin and its implications for gene expression. Ramani provided a fascinating perspective on how variations in chromatin structure could affect gene activity, highlighting potential avenues for future research that aims to untangle the complex dynamics at play in both healthy and diseased states.   References Ramani, V., Cusanovich, D., Hause, R. et al. Mapping 3D genome architecture through in situ DNase Hi-C. Nat Protoc 11, 2104–2121 (2016). https://doi.org/10.1038/nprot.2016.126 Nour J Abdulhay, Colin P McNally, Laura J Hsieh, Sivakanthan Kasinathan, Aidan Keith, Laurel S Estes, Mehran Karimzadeh, Jason G Underwood, Hani Goodarzi, Geeta J Narlikar, Vijay Ramani (2020) Massively multiplex single-molecule oligonucleosome footprinting eLife 9:e59404. https://doi.org/10.7554/eLife.59404 Abdulhay, N.J., Hsieh, L.J., McNally, C.P. et al. Nucleosome density shapes kilobase-scale regulation by a mammalian chromatin remodeler. Nat Struct Mol Biol 30, 1571–1581 (2023). https://doi.org/10.1038/s41594-023-01093-6 Nanda, A.S., Wu, K., Irkliyenko, I. et al. Direct transposition of native DNA for sensitive multimodal single-molecule sequencing. Nat Genet 56, 1300–1309 (2024). https://doi.org/10.1038/s41588-024-01748-0   Related Episodes Epigenetic Mechanisms in Genome Regulation and Developmental Programming (James Hackett) Chromatin Profiling: From ChIP to CUT&RUN, CUT&Tag and CUTAC (Steven Henikoff) Split-Pool Recognition of Interactions by Tag Extension (SPRITE) (Mitch Guttman)   Contact Epigenetics Podcast on X Epigenetics Podcast on Instagram Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Epigenetics Podcast on Threads Active Motif on X Active Motif on LinkedIn Email: podcast@activemotif.com

Predicting how influenza viruses will evolve, how deserts decompose matter despite the dry, what worms are revealing about a gene linked to autism, and what makes mice fearful of cat smells. Dr Chris Smith talks to the authors of the latest leading research in eLife... Get the references and the transcripts for this programme from the Naked Scientists website

Pour cette nouvelle émission, Vanadís reçoit, e-life unit, un duo rennais composé de Blanca Brusci et Swing Loww

In this episode of the Epigenetics Podcast, we talked with Maxim Greenberg from the Institute Jacob Monot about his work on epigenetic consequences of DNA methylation in development. In this interview we explore how Dr. Greenbergs work at UCLA involved pioneering experiments on DNA methylation mechanisms and how this period was marked by significant collaborative efforts within a highly competitive yet supportive lab environment that ultimately lead to publications in high impact journals. His transition to a postdoctoral position at the Institut Curie with Deborah Bourc'his harnessed his newfound expertise in mammalian systems, examining chromatin changes and the implications for embryonic development. Dr. Greenberg explained the nuances of his research, particularly how chromatin modifications during early development can influence gene regulatory mechanisms later in life, providing a compelling narrative about the potential long-term impacts of epigenetic changes that occur in utero. Throughout our conversation, we examined the intricate relationship between DNA methylation and Polycomb repression, discussing how these epigenetic mechanisms interact and the functional outcomes of their regulation. Dr. Greenberg's insights into his recent studies reveal a commitment to unraveling the complexities of enhancer-promoter interactions in the context of epigenetic regulation.   References Greenberg, M. V., Ausin, I., Chan, S. W., Cokus, S. J., Cuperus, J. T., Feng, S., Law, J. A., Chu, C., Pellegrini, M., Carrington, J. C., & Jacobsen, S. E. (2011). Identification of genes required for de novo DNA methylation in Arabidopsis. Epigenetics, 6(3), 344–354. https://doi.org/10.4161/epi.6.3.14242 Greenberg, M. V., Glaser, J., Borsos, M., Marjou, F. E., Walter, M., Teissandier, A., & Bourc'his, D. (2017). Transient transcription in the early embryo sets an epigenetic state that programs postnatal growth. Nature genetics, 49(1), 110–118. https://doi.org/10.1038/ng.3718 Greenberg, M., Teissandier, A., Walter, M., Noordermeer, D., & Bourc'his, D. (2019). Dynamic enhancer partitioning instructs activation of a growth-related gene during exit from naïve pluripotency. eLife, 8, e44057. https://doi.org/10.7554/eLife.44057 Monteagudo-Sánchez, A., Richard Albert, J., Scarpa, M., Noordermeer, D., & Greenberg, M. V. C. (2024). The impact of the embryonic DNA methylation program on CTCF-mediated genome regulation. Nucleic acids research, 52(18), 10934–10950. https://doi.org/10.1093/nar/gkae724 Richard Albert, J., Urli, T., Monteagudo-Sánchez, A., Le Breton, A., Sultanova, A., David, A., Scarpa, M., Schulz, M., & Greenberg, M. V. C. (2024). DNA methylation shapes the Polycomb landscape during the exit from naive pluripotency. Nature structural & molecular biology, 10.1038/s41594-024-01405-4. Advance online publication. https://doi.org/10.1038/s41594-024-01405-4   Related Episodes DNA Methylation and Mammalian Development (Déborah Bourc'his) Circulating Epigenetic Biomarkers in Cancer (Charlotte Proudhon) Epigenetic Mechanisms in Genome Regulation and Developmental Programming (James Hackett)   Contact Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com

It's time for the grand finale of 2024! Powermode Episode 76 brings you over two hours of non-stop energy with the ultimate Hardstyle Yearmix. This massive episode celebrates an unforgettable year for Hardstyle and for Primeshock, who dropped a total of 11 tracks in 2024! From crazy melodies to crowd-favorite bangers, this mix is packed with the very best of 2024. Whether you've been with us all year or just tuning in now, this episode is a must listen and the perfect recap of the past 12 months. Buckle up and switch into Powermode; the Hardstyle Yearmix of 2024!

In deze aflevering van Generatiekloof? onderzoeken we de rol van onafhankelijke labels in de hiphop met René Phillips, oprichter van het invloedrijke CMC Records, en Geert Maes, oprichter van het jonge Fresh Flows Records. René vertelt over zijn pionierswerk in de jaren '90, waarin hij met CMC Records een platform creëerde voor Nederlandse urban artiesten zoals E-Life en Postman. Geert deelt zijn ervaringen als jonge label-eigenaar, gericht op het ondersteunen van artiesten in hun groei en het uitbrengen van hun muziek. Samen bespreken ze de veranderingen in de muziekindustrie, de waarde van onafhankelijke labels, en hun visie op de toekomst van hiphop in Nederland.

Robert (Bob) Wilson is an Associate Professor of Psychology at Georgia Tech. We talk about his tutorial paper (w/ Anne Collins) on computational modelling, and some of his recent work on detecting phishing.BJKS Podcast is a podcast about neuroscience, psychology, and anything vaguely related, hosted by Benjamin James Kuper-Smith.Support the show: https://geni.us/bjks-patreonTimestamps0:00:00: Bob's strange path through computational cognitive neuroscience0:07:37: Phishing: a computational model with real-life applications0:25:46: Start discussing Bob's paper 10 simple rules for computational modeling of behavioral data0:32:15: Rule 0: Why even do computational modelling?0:46:24: Rules 1 & 2: Design a good experiment & Design a good model1:02:51: Rule 3: Simulate!1:05:48: Rules 4 & 5: Parameter estimation and recovery1:18:28: Rule 6: Model recovery1:25:55: Rules 7 & 8: Collect data and validate the model1:33:15: Rule 9: Latent variable analysis1:36:24: Rule 10: Report your results1:37:46: Computational modelling and the open science movement1:40:17: A book or paper more people should read1:43:35: Something Bob wishes he'd learnt sooner1:47:18: Advice for PhD students/postdocsPodcast linksWebsite: https://geni.us/bjks-podTwitter: https://geni.us/bjks-pod-twtRobert's linksWebsite: https://geni.us/wilson-webGoogle Scholar: https://geni.us/wilson-scholarTwitter: https://geni.us/wilson-twtBen's linksWebsite: https://geni.us/bjks-webGoogle Scholar: https://geni.us/bjks-scholarTwitter: https://geni.us/bjks-twtReferencesEpisodes w/ Paul Smaldino: https://geni.us/bjks-smaldinohttps://geni.us/bjks-smaldino_2Bechara, Damasio, Damasio, & Anderson (1994). Insensitivity to future consequences following damage to human prefrontal cortex. Cognition.Feng, Wang, Zarnescu & Wilson (2021). The dynamics of explore–exploit decisions reveal a signal-to-noise mechanism for random exploration. Scientific Reports.Grilli, ... & Wilson (2021). Is this phishing? Older age is associated with greater difficulty discriminating between safe and malicious emails. The Journals of Gerontology: Series B.Hakim, Ebner, ... & Wilson (2021). The Phishing Email Suspicion Test (PEST) a lab-based task for evaluating the cognitive mechanisms of phishing detection. Behavior research methods.Harootonian, Ekstrom & Wilson (2022). Combination and competition between path integration and landmark navigation in the estimation of heading direction. PLoS Computational Biology.Hopfield (1982). Neural networks and physical systems with emergent collective computational abilities. PNAS.MacKay (2003). Information theory, inference and learning algorithms.Miller, Eugene & Pribram (1960). Plans and the Structure of Behaviour.Sweis, Abram, Schmidt, Seeland, MacDonald III, Thomas, & Redish (2018). Sensitivity to “sunk costs” in mice, rats, and humans. Science.Walasek & Stewart (2021). You cannot accurately estimate an individual's loss aversion using an accept–reject task. Decision.Wilson & Collins (2019). Ten simple rules for the computational modeling of behavioral data. Elife.

In this episode of the Epigenetics Podcast, we talked with Yadira Soto-Feliciano from MIT about her work on the Menin-MLL complex and the effect of small molecules on its stability in leukemia. We explore the pivotal moments that led her to cancer biology during her graduate studies, where her work included ground-breaking research on the role of the plant homeodomain Finger protein-6 (PHF-6) in leukemia. This work bridged the realms of chromatin accessibility, transcription factors, and cancer cell lineage, providing critical evidence for the concept of lineage plasticity in cancer biology—a topic that has gained significant traction in recent years. Dr. Soto-Feliciano discusses how advances in techniques like CRISPR and ChIP-sequencing have shaped her research, enabling deeper insights into the mechanisms underlying cancer cell identity. As our discussion transitions, Dr. Soto-Feliciano shares her experience in David Allis's lab, illustrating how the collaboration across diverse scientific disciplines enhanced her understanding of chromatin biology and generated significant insights into the mechanics of epigenetic regulation. Highlighting a recent 2023 publication, we unpack her findings related to the conserved molecular switch between MLL1 and MLL3 complexes. These discoveries revealed how the application of small-molecule inhibitors of the menin-MLL interaction can alter gene expression and affect leukemia cells' responses to treatments. We also touch on the operational dynamics within her lab at MIT, established during challenging times marked by the pandemic. Yadira is dedicated to fostering a collaborative and respectful environment among her team, comprised of PhD candidates and research technicians, all sharing a commitment to unraveling the complexities of chromatin regulation. She emphasizes the significance of understanding chromatin scaffold proteins and their role in regulating gene expression and genome organization.   References Soto-Feliciano, Y. M., Bartlebaugh, J. M. E., Liu, Y., Sánchez-Rivera, F. J., Bhutkar, A., Weintraub, A. S., Buenrostro, J. D., Cheng, C. S., Regev, A., Jacks, T. E., Young, R. A., & Hemann, M. T. (2017). PHF6 regulates phenotypic plasticity through chromatin organization within lineage-specific genes. Genes & development, 31(10), 973–989. https://doi.org/10.1101/gad.295857.117 Soto-Feliciano, Y. M., Sánchez-Rivera, F. J., Perner, F., Barrows, D. W., Kastenhuber, E. R., Ho, Y. J., Carroll, T., Xiong, Y., Anand, D., Soshnev, A. A., Gates, L., Beytagh, M. C., Cheon, D., Gu, S., Liu, X. S., Krivtsov, A. V., Meneses, M., de Stanchina, E., Stone, R. M., Armstrong, S. A., … Allis, C. D. (2023). A Molecular Switch between Mammalian MLL Complexes Dictates Response to Menin-MLL Inhibition. Cancer discovery, 13(1), 146–169. https://doi.org/10.1158/2159-8290.CD-22-0416 Zhu, C., Soto-Feliciano, Y. M., Morris, J. P., Huang, C. H., Koche, R. P., Ho, Y. J., Banito, A., Chen, C. W., Shroff, A., Tian, S., Livshits, G., Chen, C. C., Fennell, M., Armstrong, S. A., Allis, C. D., Tschaharganeh, D. F., & Lowe, S. W. (2023). MLL3 regulates the CDKN2A tumor suppressor locus in liver cancer. eLife, 12, e80854. https://doi.org/10.7554/eLife.80854   Related Episodes MLL Proteins in Mixed-Lineage Leukemia (Yali Dou) Targeting COMPASS to Cure Childhood Leukemia (Ali Shilatifard)   Contact Epigenetics Podcast on Instagram Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com

Recent scientific research suggests that jujube seeds, a traditional Chinese medicine, may hold the key to natural brain regeneration. Studies have shown that consuming jujube seeds can improve cognitive function, reduce inflammation in the brain, and even reverse some of the damage caused by neurodegenerative diseases. While more research is needed to fully understand the mechanisms behind these effects, jujube seeds offer a promising natural approach to promoting brain health and potentially reversing age-related cognitive decline. #jujubesseds #dementia #brainhealth Umeda Tomohiro, Sakai Ayumi, Uekado Rumi, Shigemori Keiko, Nakajima Ryota, Yamana Kei, Tomiyama Takami (2024) Simply crushed Zizyphi spinosi semen prevents neurodegenerative diseases and reverses age-related cognitive decline in mice eLife 13:RP100737 https://doi.org/10.7554/eLife.100737.1 Ziziphus jujuba, jujube seeds, brain regeneration, neurogenesis, neuroprotection, cognitive function, memory impairment, Alzheimer's disease, dementia, Parkinson's disease, oxidative stress, inflammation, neuroinflammation, antioxidant, polyphenol, triterpenoid, flavonoid, animal model, mouse model, in vitro study, cell culture, neuronal differentiation, synaptic plasticity, neurotrophic factor, traditional Chinese medicine --- Support this podcast: https://podcasters.spotify.com/pod/show/ralph-turchiano/support

La relation entre le stress et le blanchiment des cheveux est un sujet qui a intrigué les chercheurs pendant des décennies. Si l'idée que le stress puisse accélérer le grisonnement est souvent évoquée, des études scientifiques récentes ont permis de mieux comprendre les mécanismes biologiques impliqués et de confirmer cette hypothèse. Le Processus de Pigmentation des Cheveux La couleur des cheveux est déterminée par la présence de mélanine, un pigment produit par les mélanocytes situés dans les follicules pileux. Avec l'âge, la production de mélanine diminue naturellement, entraînant le blanchiment progressif des cheveux. Cependant, des facteurs externes, y compris le stress, peuvent influencer ce processus. Le Rôle du Stress Des études sur des modèles animaux et des recherches récentes sur des humains suggèrent que le stress peut effectivement accélérer la dépigmentation des cheveux. En 2020, une étude publiée dans *Nature* a montré que le stress aigu active le système nerveux sympathique, qui libère de la noradrénaline dans les follicules pileux. Cette libération soudaine provoque l'épuisement des cellules souches mélanocytaires, essentielles pour la production de mélanine. Une fois ces cellules souches épuisées, elles ne peuvent plus régénérer la pigmentation, ce qui entraîne le blanchiment des cheveux . Des expériences menées sur des souris ont également mis en évidence ce lien. Les chercheurs ont soumis les souris à un stress intense et ont observé une perte rapide de la pigmentation des poils. Les résultats ont révélé que la libération excessive de noradrénaline provoquait la migration et l'épuisement des cellules souches responsables de la couleur, confirmant un lien direct entre le stress et le grisonnement accéléré . Mécanismes Biologiques Le mécanisme par lequel le stress entraîne le blanchiment des cheveux est principalement lié à l'activation du système nerveux sympathique et à la libération d'hormones du stress, telles que l'adrénaline et le cortisol. Une autre étude, publiée dans *Cell*, a montré que le stress chronique pouvait également affecter la régénération des cellules souches dans d'autres parties du corps, soulignant l'impact global du stress sur la biologie cellulaire . Stress et Blanchiment Réversible ? Une question importante est de savoir si les effets du stress sur le grisonnement sont réversibles. Bien que les effets du stress aigu puissent conduire à un épuisement permanent des cellules souches mélanocytaires, les chercheurs ont observé que dans certains cas de stress temporaire ou modéré, les cheveux peuvent retrouver leur couleur normale une fois que le stress est réduit. Une étude publiée dans *eLife* en 2021 a démontré que certains cheveux gris redevenaient pigmentés après une réduction significative du stress chez les participants, suggérant que le processus pourrait être, dans certains cas, partiellement réversible . Conclusion En résumé, les preuves scientifiques indiquent clairement que le stress peut accélérer le processus de blanchiment des cheveux en perturbant les cellules souches responsables de la production de mélanine. Le mécanisme principal implique la libération de noradrénaline et d'autres hormones du stress, qui épuisent ces cellules souches. Toutefois, dans certains cas, la réduction du stress peut potentiellement inverser partiellement le processus. Ces découvertes soulignent l'impact profond que le stress peut avoir non seulement sur la santé mentale, mais aussi sur la biologie cellulaire et l'apparence physique. Hébergé par Acast. Visitez acast.com/privacy pour plus d'informations.

先週に続き慶應義塾大学理工学部教授の牛場潤一さんをゲストに迎えて『「よく学びよく遊べ」の意味～後続のために果たすべき役割とは』をテーマにトークセッションを行います。＜目次＞00:35　フリクションとイノベーション04:58　歴史ある分野での新しさの受け容れかた12:57　受け容れる側のマインドが試される20:53　内なる動機の追求がもたらす圧倒的な結果24:58　「よく学びよく遊べ」の意味30:48　自分の方法で世界を見るレンズを持ち続ける38:22　リスナーへの『問い』＜ゲストプロフィール＞牛場 潤一（ウシバ・ジュンイチ）慶應義塾大学理工学部教授。1978年7月8日生まれ、東京都出身。2001年、慶應義塾大学理工学部卒。2004年に博士（工学）を取得。同年、生命情報学科に助手として着任。以降、専任講師（'07〜）、准教授（'12〜）、基礎科学・基盤工学インスティテュート（KiPAS）主任研究員（'14〜'18）を経て、2022年より教授。研究成果活用企業株式会社LIFESCAPES（'19〜）の代表取締役社長を兼務。The BCI Research Award 2019, 2017, 2013, 2012, 2010 Top 10-12 Nominees、文部科学省「平成27年度若手科学者賞(ブレイン・マシン・インターフェースによる神経医療研究）ほか、受賞多数。 脳が本来持つ「やわらかさ」に着目し、一人ひとりが豊かで人間らしい日々を過ごすためのテクノロジーの創造を目指し、脳と機械を接続して身体運動を補助するブレイン・マシン・インターフェース技術（BMI）の基礎研究から応用研究、医療機器開発までを、一気通貫で取り組んでいる。 近年の代表的な論文に、”Beta rhythmicity in human motor cortex reflects neural population coupling that modulates subsequent finger coordination stability (Communications Biology 2022)”、” Spatially bivariate EEG-neurofeedback can manipulate interhemispheric inhibition (Elife 2022)”、” Thirty-minute motor imagery exercise aided by EEG sensorimotor rhythm neurofeedback enhances morphing of sensorimotor cortices; A double-blind sham-controlled study (Cerebral Cortex 2022)”など。◼︎プラダアンバサダーの永野芽郁と、魚類学者のさかなクンが、海に住む生き物について、またその生き物たちが抱えている問題について語り合う「PRADA OCEAN PODCAST」配信中！https://sbwl.to/40xPc2b

慶應義塾大学理工学部教授の牛場潤一さんをゲストに迎えて『「やわらかい」脳の再配線〜麻痺を治せる世界に向けて』をテーマにトークセッションを行います。＜目次＞00:35　オープニングトーク01:52　人間の脳の可塑性08:36　BMI＝ブレイン・マシン・インターフェース12:41 「やわらかい」脳の大きな可能性17:11　麻痺を治すための脳の再配線　23:41　世界のBMI研究最前線27:05　BMI研究を続ける難しさ30:28　BMIのイメージを変えた学生の声34:23　BMI研究に至るまでのキャリア37:46　コンテクストデザインとの共通意識＜ゲストプロフィール＞牛場 潤一（ウシバ・ジュンイチ）慶應義塾大学理工学部教授。1978年7月8日生まれ、東京都出身。2001年、慶應義塾大学理工学部卒。2004年に博士（工学）を取得。同年、生命情報学科に助手として着任。以降、専任講師（'07〜）、准教授（'12〜）、基礎科学・基盤工学インスティテュート（KiPAS）主任研究員（'14〜'18）を経て、2022年より教授。研究成果活用企業株式会社LIFESCAPES（'19〜）の代表取締役社長を兼務。The BCI Research Award 2019, 2017, 2013, 2012, 2010 Top 10-12 Nominees、文部科学省「平成27年度若手科学者賞(ブレイン・マシン・インターフェースによる神経医療研究）ほか、受賞多数。 脳が本来持つ「やわらかさ」に着目し、一人ひとりが豊かで人間らしい日々を過ごすためのテクノロジーの創造を目指し、脳と機械を接続して身体運動を補助するブレイン・マシン・インターフェース技術（BMI）の基礎研究から応用研究、医療機器開発までを、一気通貫で取り組んでいる。 近年の代表的な論文に、”Beta rhythmicity in human motor cortex reflects neural population coupling that modulates subsequent finger coordination stability (Communications Biology 2022)”、” Spatially bivariate EEG-neurofeedback can manipulate interhemispheric inhibition (Elife 2022)”、” Thirty-minute motor imagery exercise aided by EEG sensorimotor rhythm neurofeedback enhances morphing of sensorimotor cortices; A double-blind sham-controlled study (Cerebral Cortex 2022)”など。

In this episode of the Epigenetics Podcast, we talked with Carl Wu from John's Hopkins University about his work on nucleosome remodeling, histone variants, and the role of single-molecule imaging in gene regulation. Our discussion starts with Carl Wu sharing his first significant milestones, a paper in "Cell" and the serendipitous discovery of DNA hypersensitive sites, which transformed our understanding of chromatin accessibility and its implications for gene regulation. As we delve into Dr. Wu's specific areas of research, he elaborates on the biochemistry of nucleosome remodeling and the intricate role of chromatin remodeling enzymes like NURF. We discuss how these enzymes employ ATP hydrolysis to reposition nucleosomes, making DNA accessible for transcription. He then explains the collaborative relationship between chromatin remodelers and transcription factors, showcasing the fascinating interplay that governs gene expression and regulatory mechanisms. The conversation takes a deeper turn as we explore Carl Wu's groundbreaking studies on histone variants, particularly H2AZ. He elucidates the role of SWR1 in facilitating the exchange between H2A and H2AZ in nucleosome arrays. The high-resolution structural insights garnered from recent studies reveal how the enzyme mediates histone eviction and insertion with remarkable precision, providing a clearer picture of chromatin dynamics at a molecular level.   References Wu, C., Bingham, P. M., Livak, K. J., Holmgren, R., & Elgin, S. C. (1979). The chromatin structure of specific genes: I. Evidence for higher order domains of defined DNA sequence. Cell, 16(4), 797–806. https://doi.org/10.1016/0092-8674(79)90095-3 Wu, C., Wong, Y. C., & Elgin, S. C. (1979). The chromatin structure of specific genes: II. Disruption of chromatin structure during gene activity. Cell, 16(4), 807–814. https://doi.org/10.1016/0092-8674(79)90096-5 Wu C. (1980). The 5' ends of Drosophila heat shock genes in chromatin are hypersensitive to DNase I. Nature, 286(5776), 854–860. https://doi.org/10.1038/286854a0 Wu, C., Wilson, S., Walker, B., Dawid, I., Paisley, T., Zimarino, V., & Ueda, H. (1987). Purification and properties of Drosophila heat shock activator protein. Science (New York, N.Y.), 238(4831), 1247–1253. https://doi.org/10.1126/science.3685975 Mizuguchi, G., Shen, X., Landry, J., Wu, W. H., Sen, S., & Wu, C. (2004). ATP-driven exchange of histone H2AZ variant catalyzed by SWR1 chromatin remodeling complex. Science (New York, N.Y.), 303(5656), 343–348. https://doi.org/10.1126/science.1090701 Kim, J. M., Visanpattanasin, P., Jou, V., Liu, S., Tang, X., Zheng, Q., Li, K. Y., Snedeker, J., Lavis, L. D., Lionnet, T., & Wu, C. (2021). Single-molecule imaging of chromatin remodelers reveals role of ATPase in promoting fast kinetics of target search and dissociation from chromatin. eLife, 10, e69387. https://doi.org/10.7554/eLife.69387   Related Episodes Multiple challenges of ATAC-Seq, Points to Consider (Yuan Xue) Pioneer Transcription Factors and Their Influence on Chromatin Structure (Ken Zaret) ATAC-Seq, scATAC-Seq and Chromatin Dynamics in Single-Cells (Jason Buenrostro)   Contact Epigenetics Podcast on X Epigenetics Podcast on Instagram Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Epigenetics Podcast on Threads Active Motif on X Active Motif on LinkedIn Email: podcast@activemotif.com

Ist Stress eigentlich schlechter für uns, wenn wir glauben, dass er schlecht ist? Wir alle kennen das Gefühl gestresst zu sein und welche negativen Folgen Stress mit sich ziehen kann. Doch inwieweit spielt unsere Sichtweise auf den Stress eine Rolle in der Stresswahrnehmung? Diesen Fragen gehen Sinja und Boris in dieser Folge auf den Grund. Wie gefällt dir Verstehen, fühlen, glücklich sein? Erzähle es uns hier.Hintergründe und Studien:Keller, A., Litzelman, K., Wisk, L., Maddox, T., Cheng, E., Creswell, P., & Witt, W. (2012). Does the perception that stress affects health matter? The association with health and mortality.. Health psychology : official journal of the Division of Health Psychology, American Psychological Association, 31 5, 677-84 Link zur Studie Nabi, H., Kivimäki, M., Batty, G., Shipley, M., Britton, A., Brunner, E., Vahtera, J., Lemogne, C., Elbaz, A., & Singh‐Manoux, A. (2013). Increased risk of coronary heart disease among individuals reporting adverse impact of stress on their health: the Whitehall II prospective cohort study.. European heart journal, 34 34, 2697-705 Link zur Studie Dhabhar FS, Malarkey WB, Neri E, McEwen BS. Stress-induced redistribution of immune cells--from barracks to boulevards to battlefields: a tale of three hormones--Curt Richter Award winner. Psychoneuroendocrinology. 2012 Sep;37(9):1345-68. doi: 10.1016/j.psyneuen.2012.05.008. Epub 2012 Jun 22. PMID: 22727761; PMCID: PMC3412918. Link zur Studie Kirby, E., Muroy, S., Sun, W., Covarrubias, D., Leong, M., Barchas, L., & Kaufer, D. (2013). Acute stress enhances adult rat hippocampal neurogenesis and activation of newborn neurons via secreted astrocytic FGF2. eLife, 2 Link zur Studie Ell, S.W., Cosley, B. & McCoy, S.K. When bad stress goes good: increased threat reactivity predicts improved category learning performance. Psychon Bull Rev 18, 96–102 (2011). Link zur Studie Crum, A., Salovey, P., & Achor, S. (2013). Rethinking stress: the role of mindsets in determining the stress response.. Journal of personality and social psychology, 104 4, 716-33 . Link zur Studie Crum, A., Santoro, E., Handley-Miner, I., Smith, E., Evans, K., Moraveji, N., Achor, S., & Salovey, P. (2023). Evaluation of the "rethink stress" mindset intervention: A metacognitive approach to changing mindsets.. Journal of experimental psychology. General. Link zur Studie Unsere allgemeinen Datenschutzrichtlinien finden Sie unter https://art19.com/privacy. Die Datenschutzrichtlinien für Kalifornien sind unter https://art19.com/privacy#do-not-sell-my-info abrufbar.

Russ Ewell's first son was born while he and his wife Gail lived in the Washington, DC area. The doctor said to him “Congratulations! You have a son.” Next the doctor said, “He has down syndrome…”. In time, they moved to Silicon Valley. Russ and his wife, Gail's, journey as parents of two children with special needs led them to start: Spiritual Resource Ministry at Bay Area Christian Church, which offers individuals with special needs and their families the ability to thrive spiritually alongside their neurotypical peers in every area of the church, which they may not otherwise be able to do. E-Sports and E-Life are free, inclusive community programs across the Bay Area enabling kids with special needs to participate in sports and activities alongside their neurotypical peers. Hope Technology School is a private, non-profit, non-sectarian K-12 school, started by Russ and Gail. HTS serves neurotypical kids and kids with special needs from all backgrounds and operates independently of BACC. HTS is regularly recognized as one of the best private schools in the Bay Area. Digital Scribbler, a company Russ founded which develops assistive tech tools for individuals with disabilities. They also have developed a Special Needs Ministry Manual that you can download at the Bay Area Christian Church website for free. (https://bacc.cc/small-groups/srm/manual/) Listen as we unpack Russ's Ministry, family life journey, and the tools to help you develop another great ministry in your area! Contact with Russ at: https://russewell.com/ _______________________________ Looking for a new student ministry resource? You can read my book “Burn Up Not Out: A Student Ministry Fire Builder's Guidebook” here: https://amzn.to/3PtBTIy Listen to more episodes from the Youth Worker On Fire Podcast here: https://bit.ly/3saDyYq _______________________________ EPISODE CREDITS Email us at: youthworkeronfire@gmail.com Hosted by: Doug Edwards Theme Song: "The One and Only" by The 808 : Listen to more at https://bit.ly/3FTYIAJ Intro/Outro Voiceover: Michael Helms : https://www.youtube.com/@MichaelTheSoundGuy  Edited by: Secret Roots Music House

In this episode, we continue our discussion of replications. We talk about how to analyze replication studies, which studies are worth replicating, and what is the status of replications in other scientific disciplines.    Shownotes Mack, R. W. (1951). The Need for Replication Research in Sociology. American Sociological Review, 16(1), 93–94. https://doi.org/10.2307/2087978 Smith, N. C. (1970). Replication studies: A neglected aspect of psychological research. American Psychologist, 25(10), 970–975. https://doi.org/10.1037/h0029774 Sidman, M. (1960). Tactics of Scientific Research: Evaluating Experimental Data in Psychology (New edition). Cambridge Center for Behavioral. Ebersole, C. R., Mathur, M. B., Baranski, E., Bart-Plange, D.-J., Buttrick, N. R., Chartier, C. R., Corker, K. S., Corley, M., Hartshorne, J. K., IJzerman, H., Lazarević, L. B., Rabagliati, H., Ropovik, I., Aczel, B., Aeschbach, L. F., Andrighetto, L., Arnal, J. D., Arrow, H., Babincak, P., … Nosek, B. A. (2020). Many Labs 5: Testing Pre-Data-Collection Peer Review as an Intervention to Increase Replicability. Advances in Methods and Practices in Psychological Science. https://doi.org/10.1177/2515245920958687 Isager, P. M., van Aert, R. C. M., Bahník, Š., Brandt, M. J., DeSoto, K. A., Giner-Sorolla, R., Krueger, J. I., Perugini, M., Ropovik, I., van 't Veer, A. E., Vranka, M., & Lakens, D. (2023). Deciding what to replicate: A decision model for replication study selection under resource and knowledge constraints. Psychological Methods, 28(2), 438–451. https://doi.org/10.1037/met0000438 Aldhous, P. (2011). Journal rejects studies contradicting precognition. New Scientist. https://www.newscientist.com/article/dn20447-journal-rejects-studies-contradicting-precognition/ Stanley, D. J., & Spence, J. R. (2014). Expectations for Replications: Are Yours Realistic? Perspectives on Psychological Science, 9(3), 305–318. https://doi.org/10.1177/1745691614528518 Simonsohn, U. (2015). Small telescopes: Detectability and the evaluation of replication results. Psychological Science, 26(5), 559–569. https://doi.org/10.1177/0956797614567341 Nosek, B.A., Errington, T.M. (2017) Reproducibility in Cancer Biology: Making sense of replications. eLife 6:e23383. https://doi.org/10.7554/eLife.23383      

LaQuita Mason, a Healthcare Administrator with a Master's Degree in Healthcare Administration concentrating in Long-Term Care, symbolizes excellence in the healthcare business. With over 18 years of broad experience, including a decade of duty in the United States Air Force, her path is defined by extraordinary accomplishments and a profound dedication to excellent care. Her […]

Killer whales are likely ramming boats because they're bored and having funSeveral years ago a small population of killer whales living off the coast of Spain began attacking boats, particularly sailboats, damaging some severely and even sinking a handful. While social media speculation has suggested whale rage as a cause, an international team of killer whale experts recently published a report suggesting the behaviour is not aggression, but is instead an example of these giant social creatures just playing and having fun with a toy. We speak with two contributors to the report: John Ford, research scientist emeritus at the Pacific Biological Station with Fisheries & Oceans Canada, and Renaud de Stephanis, the president of Spanish conservation group CIRCE.4,000-year-old Egyptian skull shows signs of possible surgery for brain cancerResearchers studying the history of cancer in human history recently hit the jackpot. In a collection of human remains at the University of Cambridge they found two skulls from Egypt, both thousands of years old, that show signs of advanced cancer. One of those skulls bore cut marks around the lesions. Lead study author and University of Santiago de Compostela professor Edgard Camarós said that regardless of whether these cuts were made as attempts at treatment or a post-mortem investigation, they show off the sophisticated medical knowledge of ancient Egyptians — and can also help better understand the evolution of cancer.This study was published in Frontiers in Medicine.Gorillas' tiny penises and low sperm count can help us understand infertility in humansGorillas are the biggest of the great apes, but their reproductive anatomy is diminutive. The males have small penises and testes, and low sperm quality. A new genetic analysis, published in the scientific journal eLife, identified the mutations that are responsible for male gorillas' peculiar fertility. Vincent Lynch, an associate professor of biological sciences at the State University of New York at Buffalo, said these findings can help us better understand the genes responsible for lower sperm quality in humans.1Illuminating plumes of hot magma in the Earth's mantle with earthquake seismic dataTo understand the source of the magma fueling volcanic eruptions, scientists are using another significant geological event: earthquakes. The seismic waves that earthquakes send through our planet can shine a light on the chimneys of magma that connect the core of the Earth through the mantle to the surface. Karin Sigloch, a professor of geophysics at CNRS — France's National Centre for Scientific Research, is part of an international effort to deploy seismic sensors throughout the oceans to illuminate the mantle plumes. Their research from recent observations in the Indian Ocean around Réunion Island was in Nature Geoscience. It's intelligence all the way down: How cells, tissues and organs have their own smartsWe tend to think of collective intelligence as something we see among animals that work cooperatively to solve problems, like in an ant colony, a school of fish or flock of birds. But biologist Michael Levin, from Harvard and Tufts' universities, thinks collective intelligence also extends to functions within the cell, all the way up to networks of cells, tissues and even organs. He suggests evolution has granted simpler biological layers in living systems the ability to flexibly solve problems. In a recent paper in Communications Biology, he argues we can harness these lower level problem-solving capabilities to make significant advances in regenerative medicine, and treating aging and disease.  

Dr. Daniele Marinazzo is a full professor in the department of data analysis at the University of Ghent, in Belgium. For over a decade he has been showing us what further information and insight we may extract from brain imaging data - from EEG and MEG to fMRI. He is technically a statistical physicist, but in reality, he is a network neuroscientist and data modeler who is constantly pushing the envelope. In this podcast he discusses some recent papers that go into how we might be able to improve the impact and relevance of new findings and models through careful benchmarking and well considered experimental design. He talks about his desire to move from correlation to causation in functional connectivity studies, he discusses granger causality, as well as moving from pairwise correlation to multivariate correlation. Furthermore, he delves into the limits of hemodynamics - limits that may be pushed back to a degree, as suggested by his compelling work showing that hemodynamic response function, which varies over space, may be estimated on a voxel-wise basis using resting state data alone. His work in estimating and mapping the Excitation/Inhibition ratio in the brain by using gamma frequency coherence as a signature was also discussed. This has potentially profound clinical and research applications. Lastly, his collaborative work with the European Human Brain Project towards the creation of the useful website, called ebrains (https://www.ebrains.eu), was discussed, which serves as a repository and tool for exploring shared data and code, as well as providing a user-friendly encapsulation of the project's collective effort. It is an all-around fun, eye-opening discussion featuring an outstanding scientist who is not only deep in the trenches of network modelling, but also a strong proponent of open science and constant engagement across disciplines. Episode producers: Omer Faruk Gulban Alfie Wearn Stephania Assimopoulos Referenced Papers: Mika Rubinov. Circular and unified analysis in network neuroscience. eLife. 2023; 12:e79559. Doi: 10.7554/eLife.79559   Reid AT, et al. Advancing functional connectivity research from association to causation. Nat Neurosci. 2019 Nov;22(11):1751-1760. Doi: 10.1038/s41593-019-0510-4.   Valdes-Sosa PA et al. Effective connectivity: Influence, causality and biophysical modelling. Neuroimage. 2009; 58(2): 339-361. Doi: 10.1016/j.neuroimage.2011.03.058.   Wu GR, et al. A blind deconvolution approach to recover effective connectivity brain networks from resting state fMRI data. Medical Image Analysis. 2013; 17(3):365-374. Doi: 10.1016/j.media.2013.01.003.

In this episode of the Epigenetics Podcast, we talked with Upasna Sharma from UC Santa Cruz about her work a number of interesting projects on H2A.Z and telomeres, the impact of paternal diet on offspring metabolism, and the role of small RNAs in sperm. In this interview Upasna Sharma discusses her work on the study of the paternal diet's impact on offspring metabolism. She reveals the discovery of small non-coding RNAs, particularly tRNA fragments, in mature mammalian sperm that may carry epigenetic information to the next generation. She explains the specific alterations in tRNA fragment levels in response to a low-protein diet and the connections found between tRNA fragments and metabolic status. Dr. Sharma further explains the degradation and stabilization of tRNA fragments in cells and the processes involved in their regulation. She shares their observation of tRNA fragment abundance in epididymal sperm, despite the sperm being transcriptionally silent at that time. This leads to a discussion on the role of the epididymis in the reprogramming of small RNA profiles and the transportation of tRNA fragments through extracellular vesicles. The conversation then shifts towards the potential mechanism of how environmental information could be transmitted to sperm and the observed changes in small RNAs in response to a low-protein diet. Dr. Sharma discusses the manipulation of small RNAs in embryos and mouse embryonic stem cells, revealing their role in regulating specific sets of genes during early development. However, the exact mechanisms that link these early changes to metabolic phenotypes are still being explored. References Sharma, U., Conine, C. C., Shea, J. M., Boskovic, A., Derr, A. G., Bing, X. Y., Belleannee, C., Kucukural, A., Serra, R. W., Sun, F., Song, L., Carone, B. R., Ricci, E. P., Li, X. Z., Fauquier, L., Moore, M. J., Sullivan, R., Mello, C. C., Garber, M., & Rando, O. J. (2016). Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals. Science (New York, N.Y.), 351(6271), 391–396. https://doi.org/10.1126/science.aad6780 Sharma, U., Sun, F., Conine, C. C., Reichholf, B., Kukreja, S., Herzog, V. A., Ameres, S. L., & Rando, O. J. (2018). Small RNAs Are Trafficked from the Epididymis to Developing Mammalian Sperm. Developmental cell, 46(4), 481–494.e6. https://doi.org/10.1016/j.devcel.2018.06.023 Rinaldi, V. D., Donnard, E., Gellatly, K., Rasmussen, M., Kucukural, A., Yukselen, O., Garber, M., Sharma, U., & Rando, O. J. (2020). An atlas of cell types in the mouse epididymis and vas deferens. eLife, 9, e55474. https://doi.org/10.7554/eLife.55474   Related Episodes The Epigenetics of Human Sperm Cells (Sarah Kimmins) Transgenerational Inheritance and Evolution of Epimutations (Peter Sarkies) The Role of Small RNAs in Transgenerational Inheritance in C. elegans (Oded Rechavi)   Contact Epigenetics Podcast on X Epigenetics Podcast on Instagram Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Epigenetics Podcast on Threads Active Motif on X Active Motif on LinkedIn Email: podcast@activemotif.com

Maria Guerreiro ORCID: 0000-0003-0010-6895 Maria Guerreiro is the Head of Partnership Development at Dryad. She is an open science enthusiast who enjoys working collaboratively with researchers and other stakeholders in scholarly communication to drive positive change. She is Head of Partnership Development at Dryad, where she leads the partnership recruitment programme with publishers, scholarly societies and research institutions. Prior to Dryad, Maria spent a decade in journal publishing, primarily at eLife, where she was Head of Journal Development and worked directly with scientists, research organizations and funding agencies in the biomedical and life sciences in initiatives to drive growth, foster community engagement and promote best practices in peer review and scientific publishing. Sarah Lippincott ORCID: 0000-0002-5700-5844 Sarah Lippincott is a librarian and library consultant with a decade of experience supporting open access, digital scholarship, and scholarly communications through strategic planning, research, service design, facilitation, and communications work. As Head of Community Engagement at Dryad, Sarah works with institutions, funders, and researchers to increase awareness of and engagement with data sharing and data reuse. She received her MLS from University of North Carolina-Chapel Hill and prior to joining Dryad, she worked in a variety of roles within and adjacent to libraries. Sarah started her career as the founding Program Director for the Library Publishing Coalition and went on to coordinate assessment, user experience, and strategic planning activities for a major research library; led strategic consulting services for a digital services agency specializing in open source web development for the cultural heritage sector; and consulted on projects for the Educopia Institute, the Next Generation Library Publishing project (NGLP), the Library Publishing Coalition, Candid, the Preservation of Electronic Government Information (PEGI) Project, the Association of Research Libraries (ARL), and the Digital Public Library of America (DPLA). Find more podcast episodes here: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://access2perspectives.pubpub.org/podcast⁠⁠⁠⁠⁠⁠⁠⁠⁠ Host:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Dr Jo Havemann⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠, ORCID iD ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠0000-0002-6157-1494 ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Editing: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Ebuka Ezeike⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Music:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Alex Lustig⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠, produced by⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Kitty Kat ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ License:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Attribution 4.0 International (CC BY 4.0)   ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ At Access 2 Perspectives, we guide you in your complete research workflow toward state-of-the-art research practices and in full compliance with funding and publishing requirements. Leverage your research projects to higher efficiency and increased collaboration opportunities while fostering your explorative spirit and joy. Website: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://access2perspectives.pubpub.org⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ --- Send in a voice message: https://podcasters.spotify.com/pod/show/access2perspectives/message

The title of this episode says it all. Today, we're going to be dealing with the fate of Antioch once Ptolemy III comes strolling over. Plus, we'll finally get to move Seleucus around a bit and see some divine justice being doled out by the weather system... Sources for this episode: Bevan, E. R. (1902), The House of Seleucus (Vol. I). London: Edward Arthur (eBook). Grainger, J. D. (2014), The Rise of the Seleukid Empire (323- 223 BCE), Seleukos I to Seleukos III. Barnsley: Pen & Sword Books Ltd. (eBook). Rosenberg, A. M., Rausser, S., Ren, J., Mosharov, E. V., Sturm, G., Odgon, R. T., Patel, P., Soni, R. K., Lacefield, C., Tobin, D. J., Paus, R. and Picard, M. (2021), Quantitative mapping of human hair greying and reversal in relation to life stress. eLife 10: e67437. Watson, J. S. (1853), on Attalus (date unknown), Justinus: Epitome of Pompeius Trogus' Philippic Histories (online) (Accessed 23/10/2023). Author unknown, Wikipedia (date unknown), Xanthippus (Spartan commander) (online) (Accessed 21/11/2023).

We look at the most common ECG rhythms and patterns seen in Medicine, including main identifying features of each. Consider subscribing on YouTube (if you found any of the info useful!): https://www.youtube.com/channel/UCRks8wB6vgz0E7buP0L_5RQ?sub_confirmation=1Patreon: https://www.patreon.com/rhesusmedicineBuy Us A Coffee!: https://www.buymeacoffee.com/rhesusmedicineRecommended sources for further reading:https://litfl.com/ecg-library/https://ecgwaves.com/Timestamps:0:00 Sinus Rhythm (Sinus Tachycardia & Sinus Bradycardia1:06 Atrial Fibrillation 2:35 – AF video link2:38 Atrial Flutter4:26 Premature Ventricular Contraction (PVCs) & Premature Atrial Contractions (PACs)5:40 Bundle Branch Block (LBBB & RBBB) 6:41 1st Degree AV Block7:03 2nd Degree AV Block - Mobitz 1 (Wenckebach) & Mobitz 2 (Hay)7:39 3rd Degree Heart Block (Complete Heart Block) 8:15 Heart Block Video Link8:19 Ventricular Tachycardia & Ventricular Fibrillation10:20 ST ElevationReferences:Nickson, C - Life in the Fast Lane (2023) Atrial Fibrillation. Available at https://litfl.com/atrial-fibrillation/Buttner, R. Burns, E - Life in the Fast Lane (2022) Atrial Flutter. Available at https://litfl.com/atrial-flutter-ecg-library/Larkin, J. Burns, E - Life in the Fast Lane (2021) AV Block: 1st Degree. Available at https://litfl.com/first-degree-heart-block-ecg-library/Burns, E. Buttner, R - Life in the Fast Lane (2021) AV Block: 2nd degree, Mobitz I (Wenckebach Phenomenon). Available at https://litfl.com/av-block-2nd-degree-mobitz-i-wenckebach-phenomenon/Burns, E. Buttner, R - Life in the Fast Lane (2022) AV Block: 2nd degree, Mobitz II (Hay block). Available at https://litfl.com/av-block-2nd-degree-mobitz-ii-hay-block/Larkin, J. Buttner, R. - Life in the Fast Lane (2023) AV Block: 3rd Degree. Available at https://litfl.com/av-block-3rd-degree-complete-heart-block/Buttner, R. Burns, E - Life in the Fast Lane (2023) Ventricular Tachycardia – Monomorphic VT. Available at https://litfl.com/ventricular-tachycardia-monomorphic-ecg-library/Burns, E. Buttner, R - Life in the Fast Lane (2022) The ST Segment. Available at https://litfl.com/st-segment-ecg-library/British Heart Foundation Atrial Flutter and Atrial Fibrillation. Available at https://www.bhf.org.uk/informationsupport/heart-matters-magazine/medical/ask-the-experts/atrial-flutterECG Waves The ECG Book. Available at https://ecgwaves.com/course/the-ecg-book/Please remember this podcast and all content from Rhesus Medicine is meant for educational purposes only and should not be used as a guide to diagnose or to treat. Please consult a healthcare professional for medical advice. 

In this episode I talk about a surgery I just had. That I'm hoping will change my life for the BETTER. This episode was recorded in “real time” the morning of my surgery (my thoughts getting ready to go to the hospital and emotions) and (almost) 24 hours after my surgery (how I'm feeling, what I had done, mishaps, pain etc). I am planning a part 2 to this 6-12 months later to let you know if the surgery was a success for me and my health journey. #surgery #health #journey #reproductivehealth #mylife #mystory #real #reallife #mylifestory

Chromosomal recombination is an essential part of the life cycle of all sexually reproducing organisms. Yet, the system is complex, involving hundreds to thousands of proteins and RNAs. It also involves DNA repair pathways, which are themselves incredibly complex. The newest available information on recombination tells us it is mutagenic, meaning that recombination erodes the very places where recombination happens. How did such a system arise by chance? Can we assume the recombination rate has always been the same? What happens when a new allele arises in the protein that controls recombination? What is the mutation burden caused by this important system? Finally, how does this affect the creation-evolution debate? Links and notes: 15 Questions for evolutionists, #8 How did sex originate? Geeking out about DNA damage repair, June 2023. Grey et al. 2018 PRDM9, a driver of the genetic map, PLoS Genet 14(8):e1007479. Altemose et al. 2017 A map of human PRDM9 binding provides evidence for novel behaviors of PRDM9 and other zinc-finger proteins in meiosis, eLife 6:e28383. Robert Carter gets everything wrong?, creation.com, 10 Jul 2021. Hussin et al. 2011 Age-dependent recombination rates in human pedigrees, PloS Genetics 7(9):e1002251. Wang et al. 2012 Genome-wide single-cell analysis of recombination activity and de novo mutation rates in human sperm, Cell 150(2):402–12. African origins and the rise of carnivory, creation.com,19 Dec 2020. Hinch, A.G. et al., The landscape of recombination in African Americans, Nature 476:170–177, 2011. Hinch et al. 2023 Meiotic DNA breaks drive multifaceted mutagenesis in the human germ line, Science 382:eadh2531.

“Science can only progress if others are able to read and build off of what has been learned in the past.” Jessica Polka shares this insight and many more in this conversation with LSP about the current state of scientific publishing. As the executive director of ASAPbio, an organization battling the slowing of the sharing of scientific knowledge, she's played a key role in catalyzing change when it comes to how and when scientific articles are shared. We dive into the White House memo calling for all scientific papers to be open access by 2025, what some of her key concerns are for the space, and that explosive eLife announcement about preprints. You won't want to miss this great conversation! Links for Jessica:Twitter: https://twitter.com/jessicapolkaLinkedIn: https://www.linkedin.com/in/jessicapolka/ASAPbio: www.asapbio.org

In this episode of the Epigenetics Podcast, we caught up with Sheila Teves from the University of British Columbia to talk about her work on the inheritance of transcriptional memory by mitotic bookmarking. Early in her research career, Sheila Teves focused on the impact of nucleosomes on torsional stress and gene regulation. She also highlights the development of a genome-wide approach to measure torsional stress and its relationship to nucleosome dynamics and RNA polymerase regulation. The conversation then shifts to her focus on transcriptional memory and mitotic bookmarking during her postdoc in the Tijan lab. She explores the concept of mitotic bookmarking, whereby certain transcription factors remain bound to their target sites during mitosis, facilitating efficient reactivation of transcription after cell division. She discusses her findings on the behavior of transcription factors on mitotic chromosomes, challenging the notion that they are excluded during mitosis. She also discusses the differences in binding behavior between the general transcription factor TBP and other transcription factors. Finally, the effect of formaldehyde fixation on the potential to find transcription factors bound to mitotic chromosomes is discussed.   References Teves, S., Henikoff, S. Transcription-generated torsional stress destabilizes nucleosomes. Nat Struct Mol Biol 21, 88–94 (2014). https://doi.org/10.1038/nsmb.2723 Sheila S Teves, Luye An, Anders S Hansen, Liangqi Xie, Xavier Darzacq, Robert Tjian (2016) A dynamic mode of mitotic bookmarking by transcription factors eLife 5:e22280. https://doi.org/10.7554/eLife.22280 Sheila S Teves, Luye An, Aarohi Bhargava-Shah, Liangqi Xie, Xavier Darzacq, Robert Tjian (2018) A stable mode of bookmarking by TBP recruits RNA polymerase II to mitotic chromosomes eLife 7:e35621. https://doi.org/10.7554/eLife.35621 Kwan, J. Z. J., Nguyen, T. F., Uzozie, A. C., Budzynski, M. A., Cui, J., Lee, J. M. C., Van Petegem, F., Lange, P. F., & Teves, S. S. (2023). RNA Polymerase II transcription independent of TBP in murine embryonic stem cells. eLife, 12, e83810. https://doi.org/10.7554/eLife.83810 Price, R. M., Budzyński, M. A., Shen, J., Mitchell, J. E., Kwan, J. Z. J., & Teves, S. S. (2023). Heat shock transcription factors demonstrate a distinct mode of interaction with mitotic chromosomes. Nucleic acids research, 51(10), 5040–5055. https://doi.org/10.1093/nar/gkad304   Related Episodes In Vivo Nucleosome Structure and Dynamics (Srinivas Ramachandran) From Nucleosome Structure to Function (Karolin Luger) Structural Analysis of Nucleosomes During Transcription (Lucas Farnung)   Contact Epigenetics Podcast on Twitter Epigenetics Podcast on Instagram Epigenetics Podcast on Mastodon Active Motif on Twitter Active Motif on LinkedIn Email: podcast@activemotif.com

This month, how an extinct marine mammal made its haemoglobin work in the cold, how does learning compassion change the shape of the human brain, women publishing cautiously, how populations evolve to social distance in disease conditions, and can biochemical clocks accurately track ageing in children? Join Dr Chris Smith for a look at some of eLife's latest leading papers... Get the references and the transcripts for this programme from the Naked Scientists website

Presenting a sham treatment as personalised increases the placebo effect in a randomised controlled trial. Sandra DA, Olson JA, Langer EJ, et al. eLife. 2023;12:e84691. doi:10.7554/eLife.84691 Due to copyright laws, unless the article is open source we cannot legally post the PDF on the website for the world to download at will. Brought to you by CSMi – https://www.humacnorm.com/ptinquest Learn more about/Buy Erik's courses – The Science PT Support us on the Patreons! Music for PT Inquest: “The Science of Selling Yourself Short” by Less Than Jake Used by Permission Other Music by Kevin MacLeod – incompetech.com: MidRoll Promo – Mining by Moonlight

A fascinating new look at treating periodontal disease using macrophages differently. Katrina Sanders, RDH takes a look at work coming from Kings College in London related to using telocytes as a regulator of M1 vs M2 macrophages! Resources: More Fast Facts: https://www.ataleoftwohygienists.com/fast-facts/ Katrina Sanders Website: https://www.katrinasanders.com  Katrina Sanders Instagram:   https://www.instagram.com/thedentalwinegenist/  Jing Zhao, Anahid A Birjandi, Mohi Ahmed, Yushi Redhead, Jose Villagomez Olea, Paul Sharpe (2022). Telocytes regulate macrophages in periodontal disease. Published in eLife https://doi.org/10.7554/eLife.72128    

This week Matthew speaks with Jenny Tung, McArthur fellow and the director of the Max Planck Institute for Evolutionary Anthropology.They start out by discussing the mutual benefits that molecular biologists and behavioral ecologists can gain from bringing their methods and frameworks together. They discuss two examples of the power of that synergy from Jenny's work as a co-director of the Amboseli Baboon Research Project: (1) unraveling the hybridization history of the population and the behavioral impacts of hybrid ancestry and (2) measuring "biological" age and its predictors. They close by discussing Jenny's new role as director of MPI for Evolutionary Anthropology.Papers Relevant to this Week's episode:Hybridization in the Amboseli population:Vilgalys, T. P., Fogel, A. S., Anderson, J. A., Mututua, R. S., Warutere, J. K., Siodi, I. L. I., ... & Tung, J. (2022). Selection against admixture and gene regulatory divergence in a long-term primate field study. Science, 377(6606), 635-641.Biological aging in baboons:Anderson, J. A., Johnston, R. A., Lea, A. J., Campos, F. A., Voyles, T. N., Akinyi, M. Y., ... & Tung, J. (2021). High social status males experience accelerated epigenetic aging in wild baboons. Elife, 10, e66128.Credits: The Animal Behavior Podcast is created by a team of animal behavior researchers and audio professionals. Come meet us here! We receive production support from the Cornell Broadcast studio directed by Bert Odom-Reed, and financial support from the Animal Behavior Society.

Eric Topol (00:00):Hello, this is Eric Topol, and I'm thrilled to have a chance to have a conversation with Magdalena Skipper, who is the Editor-in-Chief of Nature. And a historic note. Back in 2018, she became the first woman editor of Nature in its 149 years, and only the eighth editor of all times. Having taken over for Philip Campbell, who had been previously the editor for 22 years, we're going to ask her if she's going to do 22 or more years, but we're going to have a fun conversation because there's so much going on in medical publishing, and I think, you know, that Nature is the number one cited science journal in the world. So, welcome, Magdalena.Magdalena Skipper (00:41):Thank you very much. Real pleasure to be here and chatting with you today, Eric. Thank you.How COVID-19 Affected NatureEric Topol (00:47):Well, you know, we're still, of course, in the pandemic world. It's obviously not as bad as it had been, but there's still things going on with new variants and Long Covid, and it's not, the virus isn't going away. But first thing I wanted to get into was how did Nature handle this frenetic craziness? I mean, it was putting out accelerated publications on almost a daily or weekly basis and putting out like a speed, velocity of the likes that we've not seen. This must have been really trying for the whole crew. What, what do you think?Magdalena Skipper (01:29):It was! And, you know, the first thing I, I think I will recognize two things at the same time. So the first one, as you say, at a time, such as the pandemic, but actually at any point when there is a, a new health emergency that is spreading, especially something as unknown, as new as, as it was the case with SARS-CoV-2. And of course, in the beginning, we really knew nothing about what we were facing if speed is of the essence, but equally what's truly important is of course, the rigor itself. So that combination of needing to publish as quickly as possible, but at the same time as rigorously evaluating the papers as possible, that was actually quite a challenge. And of course, you know, what we sometimes forget when we talk about, well, researchers themselves, but also editors and publishers is of course, as individuals, as human beings.(02:33):They are going through all the trauma, all the constraints associated with various lockdowns concerns about the loved ones, perhaps those ones who are in the care. You know, in many cases of course there would've been the elderly who are individuals would've been concerned by or indeed children, because of course, schools in so many places were. And all the while, while we were dealing with these very human, very ordinary daily preoccupations, we were very focused on the fact that we had a responsibility and a duty to publish papers and evaluate them as quickly as possible. It really was an extraordinary time. And, and you know, one other thing I should emphasize is, of course, it's not just the manuscript editors who evaluate the research, it's the reporters on my team as well who are going out of their the way to find out as much information to report as robustly, find as many sources to, to interview as possible.(03:44):And, and, you know, I also have to mention colleagues who work on production side of nature actually make Naturehappen, be published online on a daily and then of course weekly basis. And literally from one week to the next all our operations had to be performed from home. And it's really remarkable that the issue was not late. We published the issue, just as you know, from as lockdowns came in. And as it happens, the production side of Nature is mainly based in, in London. So most of that team effectively found themselves not being able to go to the office effectively from one day to the next. So it really was an extraordinary time and, and a time that as I said was, was a time of great responsibility. But looking back on it, I'm actually incredibly proud of, of my team, what, what they achievedEric Topol (04:47):Did they hold up? I mean, they hadn't, they didn't get burnout from lack of sleep and lack of everything. Are they still hanging in there?Magdalena Skipper (04:55):So they are hanging in there. You'll be glad to hear. But I think, very importantly, we were there for one another insofar that we could be, of course, we were all at home remotely. We were not meeting, but we had virtual meetings, which were regular of course in as a whole team, but also in, in subgroups as we sub-teams, as we worked together, that human contact in addition to of course, loved ones and families and friends, that human contact in a professional setting was, was really, really necessary. And clearly what I'm describing was affected all of us one way or another. Sometimes there is a tendency not to remember. That also applies to editors, publishers, and of course researchers themselves. I mean, very clearly they were at the forefront of the issue facing the same problems.Nature and Challenge of Generative A.I.Eric Topol (05:57):Well, a new challenge has arisen, not that the pandemic of course has gone away, but now we have this large language models of AI, Generative AI, which you've written editorials at Nature, which, of course, is it human or is it the machine? What do you think about that challenge?Magdalena Skipper (06:19):Well of course, you know, the way I like to think about it is AI, of course, broadly is, has been around for a very long time, a number of decades, right? And steadily over the last several years, we have seen AI emerge as a really powerful and important tool in research right across a number of disciplines. The reason why we are all talking about AI right now, and I really think all of us are talking about AI all the time, is, of course, specifically the emergence of generative AI, the large language models that, that you just mentioned. And they sort of burst onto the scene for all of us really last year in the autumn with chat GPT and GPT-4 and so on. But it's important to remember that, of course, when we talk about AI, there are other models, other approaches, and machine learning in general has been creating quite some revolution in research already.(07:36): You know, probably the best example that will be familiar to many of the  listeners was of course Alpha Fold which, you know, Nature published a couple of years ago and, and has been really revolutionized structural biology. But, of course, there are many other examples which are now becoming developing much more rapidly, becoming much more, I would say, commonplace in, in research practice. You know, not just predicting structure from sequencing from sequence. And I say just so flippantly now, of course, it was such and it continues to be such an incredible tool. But of course now we have AI approaches, which actually suggest new protein design, new, new small molecule design. We've had in the last couple of years, we've had identification of new potential antibiotics that are effective against bacterial strains that have otherwise been resistant to any known antibiotics.(08:48):And, and of course, it's not just in biomedicine. Material science--I think it's very helpful, hopeful when it comes to, to AI tools as well. And then, and of course, generative AI indeed helps us in some of these contexts already. But I think your question perhaps was more focused on the publishing, the communication, the sort of output of, of research, which of course is also very important. In some way. The reason why I answered, I began to answer the question the way I did, is because I'm actually very excited about harnessing the power of AI in augmenting research itself. Helping navigate enormous data sets generate hypotheses to be tested finding new ways to advance projects. I think that's a very exciting opportunity. And we're just beginning to see the first applications of it.(10:04):Now, in terms of publishing you referred to some editorials that we wrote about this. And right at the beginning of the year, there was a flurry of excitement associated with the ability of generative AI to indeed generate text. There were some manuscripts which were published in journals that were co-authored by Chat GPT. I I even believe there was an editorial which was co-authored by Chat GPT. So in response to that, we felt very strongly that, that clearly there was a need to, to come out with a, a clear position, just as in doing research, we see AI tools as tools to support writing, but clearly they don't have the ability to fulfill authorship criteria. Clearly, they cannot be authors. Clearly, they must only remain as tools supporting researchers and individuals writing and communicating their research.(11:23):And so we, we wrote a very clear editorial about this, essentially summarizing what I just explained and asking the community to be transparent about how AI tool has been used, just as you would be transparent about your methodology, how you have arrived at the results that you're reporting and, and results that support your conclusions. So for us, it's a relatively simple set of recommendations. As I say, we ask for transparency. We understand it can be a tool that can be used to help write a paper. What we also ask at this stage that generative AI tools are not used to generate figures or images in papers, simply because there are a number of outstanding copyright issues, a number of outstanding privacy issues, they remain unresolved. And for as long as they remain unresolved, we feel it's not an appropriate application of these tools. So that's our editorial position.Eric Topol (12:42):Yeah, no, that's very helpful. I mean, where do you think, if you write a manuscript and then you put it into let's say GPT-4 and say, please edit this, is that okay? Or is that something that, and it's acknowledged that the paper was written by us researchers, but then we had it tweaked by chatbot or is that something that it wouldn't go over too well?Magdalena Skipper (13:10):Well, my preference, and actually what I would hope is that if you were writing this paper and then you felt the need to put it through a chatbot as you just put it, although I find it hard to imagine that you would find no need for that,Eric Topol (13:29):I wouldn't do it. But I know there's people out there that are working on it.Magdalena Skipper (13:32):Yeah, absolutely. But then I would hope that the last pass, the final word, would rest with you as the author. Because, of course, if you are using a tool for whatever it is that you do, you want, at the end of the day to make sure that what that tool has returned is aligned with what you intended that you perform some kind of a sense check. We, of course, all know that although GPT-4 has less of a tendency to hallucinate, so to essentially come up with fabricated sort of statements and, and reality, if you like, it remains an issue. It can remain an issue. And very clearly any, any scientific communication has to be rooted in facts. So, in the scenario that you propose, I would hope that if a researcher felt compelled to run the manuscript through a chatbot, and for example, one consideration may for an individual whose English is not their first language, who feel may feel more comfortable with a sort of support of this kind. But in the end, the final check, the final sign off, if you like, on that manuscript before submission would need to come from the researcher, from the corresponding author, from the writing group. and indeed assistance from a chatbot would need to be disclosed.Eric Topol (15:14):For us. Yeah, I mean, it's really interesting because you can almost foresee the shortcut of having to go get all the references and all the links, you could say, you know, please insert these, but you better check them because they may be fabricated Absolutely. It's going to be really interesting to see how this plays out and the difficulty of detecting what is written by a large language model versus a person.Nature and PreprintsNow another topic that I think is really in play is the preprint world and publishing via preprints. And as you know there's been Michael Eisen and the whole idea of how things would move with his journal eLife. And you will remember when you and I were together at a conference. I organized Future of Genomic Medicine many years ago at the kind of dawn of life science preprints. And some people in the audience sai, “what's a preprint?” Right? Nobody else asks about that now. It's come a long way over this decade. And where do we go with this? Should journals like the top journals in the world like Nature require a paper to be vetted through the pre-print mechanism? Where is this headed, do you think?Magdalena Skipper (16:40):Yeah, it's an excellent question. And, and you know, by the way, I have such wonderful memories from, of that conference. I think this must have been like 11 years ago or something like that. It was a long time ago. And I actually remember presenting this, this vision of a rather radical vision of, of the future of publishing. And here we are in the future as compared to then, and we have moved relatively little by comparison to where we were then. But back to your question. So, you know, the first thing to say is that, of course, just as a reminder, preprints have been around for more than two decades now. And, and of course they initially were really spearheaded and advanced by the physical sciences community. archive itself is, as I say, more than two decades old. So, you know, for us at Nature as a multidisciplinary journal where of course, we've been publishing in the physical sciences since the very beginning of our existence as soon as preprints first emerged in those communities, we realized that we could coexist very harmoniously as a journal peer-review based journal with preprints.(17:59):So when initially biological sciences community embraced them and bioRxiv was established, and then of course, many other archives and then subsequently actually really spearheaded by Covid, the medical and clinical community began to embrace preprints. in many ways, for us, that was nothing new. It was just an extension of something that we worked with before. Although our own our own policies have evolved. So, for example, during the pandemic we actually mandated deposition of papers that were submitted to us that were Covid related. We mandated the deposition in a preprint server. The authors had the choice which server they deposited, but we wanted those manuscripts to be available to the community for the scrutiny as soon as they were finalized, as soon as they were actually written. So while we were reviewing them again as quickly as rigorously, but as quickly as possible, the preprint was already available for the community just before the pandemic.(19:17):As it happens, we also took a step forward with our policy. So previously, let's just say we were completely fine with preprints. We saw preprints as compatible with submission to, to Nature, and for that matter to the other journals in the Nature Portfolio. But actually just in the year before COVID started, we decided to actively encourage our authors to deposit preprints. We could see that preprint sharing had great advantage. You know, the, the usuals of advantages, which are often listed first are of course ability to make that primacy claim, make a stake that, that you have been working on something and, and this is your project. You have a set of results that you are ready to communicate to, to the community at large. And of course, another very important one is that sort of community and, and almost public form of peer review and, and ability to comment.(20:30):And incidentally, I remember as you know, my, my history as an editor very well. We've known each other for a long time. I remember when the genomics community, which is sort of my, my background is sort of my old hat, if you like, that, that I used to wear when the genomics community began to embrace preprints especially the population and evolutionary genomicists really embraced this idea that this was like a group peer review. And the authors of those preprints were very grateful to the community for improving the papers before they were submitted to journals, or sometimes that sort of community review was going on while a paper was being considered at a journal. And we, as editors actually encouraged sort of formal submission of these reviews, if you like, I mean, formal maybe is the wrong word, but we were saying that we would take those comments into account when evaluating papers.(21:38):So there has been an interesting evolution that more and more disciplines, more and more fields have embraced preprints as a way of disseminating information. Preprints service themselves have also grown and matured in the sense that there is now realization that, for example, clinical preprints need a higher degree of scrutiny they're posted on a preprint server than maybe let's say theoretical physics or theoretical biology preprints. So overall all communities collectively have grown and matured. Where are we going with this? I mean, who knows? I was predicting 12 years ago you know, a bit of a different, more advanced future today. It's very difficult to predict the future. I do think, however, that what we are seeing today, that sort of hand in glove coexistence of preprints with journals, with peer reviewed papers is going to continue into the future. And I think actually that's a really valuable and interesting combination. So it's a great development to see and great to see that communities right across disciplines have really embraced this.Eric Topol (23:11):Yeah, I think it does complement, obviously the traditional peer review of a few expert reviewers with, you know, could be hundreds if not thousands of people that weigh in on, on a pre-print. So yeah, it's fascinating to see. And it's, I still remember the vision that you portrayed for it, and how we we're not quite there yet, but I'm sure there'll be further evolution.Women in Science: Where Do We Stand?Now, another area that I think is particularly good to get your input, because you're a woman in science, as you mentioned, you know, grounded obviously in genetics and genomics, and here you are, one of the most influential women in science at a time when there's been a reckoning that women in science have been shortchanged historically, I mean, for hundreds of years. Do you see that this is starting to get better? Are there palpable signs that we're finally getting kind of equal rights here? Or are we, is it, is it just still a long fight ahead?Magdalena Skipper (24:20):So the, the optimist in me and, and I should say, you know, my, my glass, my glass is always half full. The optimist in me says that it is getting better, but the realist in me has to add immediately that the changes too slow. It really is too slow. We do see many more women prominently able to make the contributions that they should, they can, and they should make to whatever discipline whatever aspect of the research community and beyond they wish to, to make. I still think it costs them too much. I still think we don't appreciate and support women sufficiently.(25:23):Maybe we have moved on the bottleneck in the, in the pipeline a little bit further, towards more seniority. But we still, we still don't sufficiently support women. As I say, we, I think we still default to an expectation that successful women in science in research more broadly will somehow emulate how success has looked in the past. And that's a shame, that's a shame not just for those women who are trying to come in and make a difference, but it's a shame for all of us because it means that we are denying diversity in that picture of success. Yes. So yes, I think, I think that we have seen many changes, but I think the change is not happening fast enough.Eric Topol (26:23):Yeah. One of the things that I've noticed since of particular interest in AI is that the very profound imbalance of researchers, the gender imbalance there is just, you know, I'm not even sure if it's 10% women researchers in AI, so that has to be changed. And so this, there's so many things that are holding us back, but, but that's certainly one of, of many.Magdalena Skipper (26:49):Absolutely. And, and, and if I can just add, there are some outstandingly influential female researchers in the AI field, as you say, they are just outnumbered. Yes. , I think not given the opportunity to, to fully blossom, if you like, considering their capabilities and, and their contributions already.Eric Topol (27:11):You know, it's so true. I just interviewed Melanie Mitchell from the Santa Fe Institute, and I work with Fei- Fei Li. And when I, when Fei-Fei Li and I spoke some months ago about a book (Genius Makers) that Cade Metz, the New York Times journalist had written, and I say, why didn't he bring up or emphasize the role of any women in the whole book . Yes--who work in A--I mean, she, she obviously was, was did not take that particularly well, and as did I.Too Many Nature Portfolio Journals?So one of the other areas that I think you already touched on, which is separating Nature, the flagship journal from the Nature Portfolio of, I don't know what it's up to now, 200, 300, I'm not sure how many journals are. So do you, do you have to over oversee that? Do you have input on that? Because what I worry about is, you know, people quote a Nature journal and it may not be, you know, at that level that you would be proud of. What, what are your thoughts about this endless proliferation of the nature portfolio?Magdalena Skipper (28:17):Well, I, I'm, first of all, I'm not sure if it's endless, butEric Topol (28:20):Oh, that's good. .Magdalena Skipper (28:22):So, so  let me, I think in your question, you touched on a number of things. So first of all, a clarification. So my role is as Editor-in-Chief of Nature, and of course, that is my main focus. there is another aspect to my role, which is Chief Editorial Advisor for the Nature Portfolio. So in that sense each of the journals within the Nature portfolio has its own chief editor. but by virtue, I guess, of my seniority, and also by virtue of multi-disciplinarity of Nature I have this advisory role to my colleagues in the other journals. I like to think about the Nature Portfolio as an ecosystem, actually. And it's an ecosystem, like any ecosystem. It has different niches, each of which fulfills a different role. Some of them are bigger, some of them are smaller, some of them are very specialized, others are more general.(29:22):And I think you know, working with researchers for many years as an editor now, I can see benefits to having that sort of almost an ecosystem type approach to publishing. You know, for example, we mentioned already earlier that in my previous sort of incarnation as an editor, my focus was on genomics especially in the context of human genomics. of course starting from the Human Genome Project, these were very large or have, where, why, why am I using past tense? They are, to this day, very large collaborative projects involving many different labs, many different approaches these days that they're not just focused on genomics, but of course other omics go hand in hand with them. So when a project comes to fruition, when, when it comes to be published, there are many different pieces that need to be communicated, many different papers of different sizes of different value.(30:32):And for example what value maybe is the wrong word of different utility? So, for example, there may be a flagship paper that is published in the pages of my journal of Nature, but there may be papers that specifically described development of methodology that was part of the same stage of the project. And those papers may be published in Nature Methods, which is part of the Nature Portfolio. There are other journals that are part of Nature Portfolio, which have different editorial bar. And so, you know, one example is Scientific Reports, which is a journal which does not require conceptual novelty in the papers that it publishes. Of course, it requires rigor and, and robustness in the papers that it publishes, like every journal should. But there is utility in publishing papers in a journal like this.(31:36):There may be replications that are published there that further add further evidence to support conclusions that are already well known, but nevertheless, they're useful. I should however, add that in Nature itself, we also publish replications, right? There are different degrees of influence and impact that, of course, different studies be there, replications or not that can carry. So, that will be my way of conceptualizing the Nature Portfolio. and, you know, coming back to your, to your comment that it seems like it's endless. I think well, nothing, nothing is endless. Of course. Nothing, nothing, right, grows forever. I do think that we have in the launches within the portfolio, we have been able to capture and at the same time serve an interesting evolution in the research ecosystem itself. So the final comment I will make on this is, if you look at some of the more recent launches in the portfolio, they've been what we like to call thematic journals, such as, for example, Nature Food or Nature Water.Eric Topol (33:10):Right?Magdalena Skipper (33:10):And here we are really capitalizing on that multi-disciplinarity of these emerging themes that, especially in the context of sustainable development goals, have acquired their own identity. They don't belong to one discipline or another discipline. And, and so these journals, they're new journals, relatively new journals, some of them very new Nature Waters is, is quite new, but they provide a focal point for researchers who come together to solve a particular set of problems from different disciplines. And I think that's an interesting function in, as I say, for the community.What About the Paywalls?Eric Topol (33:53):Yeah, there's no question some of the newer journals and their transdisciplinary mission --they're needed and they become extremely popular and well -cited very quickly to prove that. So along that line obviously the public is all fired up about paywalls and you know, and obviously for Covid, there was no paywalls, which is pretty extraordinary. Do you see someday that journals will have a hard time of maintaining this? I mean, you have what I consider an extraordinary solution, which is the ReadCube postings anyone can access, you just can't download the PDF, and I wish authors would always routinely put that out there because that would solve part of the problem. But do you think we're going to go to a free access that's much more wide, perhaps even routine, in the years ahead?Magdalena Skipper (34:52):So certainly open access as in ability to access a manuscript, published manuscript without any payment or barrier associated with a Creative Commons license is something that is advanced as a, as a preferred future by many researchers, by many funders. and for that matter, actually many publishers as well. You know, let me make one thing very clear. As an editor, I would love as many people as possible to read the papers that I publish in my journal.Magdalena Skipper (35:30):That should go without saying. Sure. at the same time, publishing papers, of course, is associated with a cost, and, and that cost has to be somehow covered. In the old days it was exclusively covered by library subscriptions or site licenses or personal subscriptions. Now the focus is shifting. And of course, Nature itself as well as the other research journals such as, for example, Nature Medicine or indeed Nature Water, as I mentioned before are what we call transformative journals. So effectively we are hybrid journals that advocate for open access. So today, when you submit a paper to Nature, you can publish under the traditional publishing model, or you can choose to publish open access, which is associated with an article processing charge. That should, in my view, be part of your costs of doing research, because after all, I'm a firm believer in the fact that publishing your research should be seen as part of doing research, not sort of an add-on.(36:47):Now, I'm glad you mentioned read Read Cube and this functionality that we call shared it. We developed it actually quite some years ago. I would say at least a decade ago. it remains curiously underappreciated. Yeah. I just don't understand it. Yeah, exactly. And, and we, we inform the authors that they are free to use that link. And, and just to clarify, it's a linked as you exactly as you explained to an online version of the paper. It's the final version, the record version of the paper. You can't download it, but you can share that link. Anyone can share that link once they have it Infinite number of times. So it's not like the link expires, or it's a, a finite number of, of that it has a number of finite number of uses in addition to that nature.(37:49):And for that matter, the whole of Springer Nature is part of Research4Life. Now, that's an organization that provides free access to all content from publishers. And Springer Nature is not the only publisher that's part of Research for Life that provides full access to all of our content in the countries which are designated as low and middle income countries by the World Bank. So that we've been part of that. And, and previously for many, many years, in fact, decades, again, that is curiously underappreciated, including in the low and middle income countries. So, you know, recently had an opportunity to do some visits in Africa. And my, my take home message there was, if there is one thing that you remember from our conversation or from my presentation, please remember about Research4Life.Magdalena Skipper (38:52):Because that content is freely available if you follow, if you go to our content through Research4Life. And incidentally, there's also training, which is available there. So part of Nature portfolio in addition to journals, we have Nature Master classes, which is training for researchers. And that is also completely freely available in those countries. So there are a number of approaches to, to getting content open access is definitely growing, but there are those other ways to gain access to content which is not open access at the moment.Eric Topol (39:33):I'm really glad you reviewed that because a lot of people who are going to be listening are going to really cue into that. Now the last question for you is, you know, it's not just every Wednesday, 51 or whatever, 50 weeks a year, that you're getting the journal ready, but it's every day now that you're putting out stuff and on the Nature website. Features that are by the way, free or full access and many other things to keep Nature out there on a daily, if not minute to minute basis. So this is really a big charge to, you know, do this all so well. So what keeps you up at night about Nature is this, this must be a very tough position.Magdalena Skipper (40:28):So the first thing I would say that is that of course it's, it's not me. I'm just the person here talking to you representing Nature. I have an outstanding team.Eric Topol (40:44):I've met them, and they're amazing.Magdalena Skipper (40:46):And it's really them who are making it possible on a minute by minute, certainly day by day basis. And so the reason why I sleep relatively well is thanks to them actually, okay,Eric Topol (41:00):. Okay.What Keeps You Up At Night?Magdalena Skipper (41:01):But more, but more broadly. and this is a thought which is bigger than Nature itself. What actually keeps me up at night these days is the rather difficult light in which science and research is portrayed these days increasingly.Magdalena Skipper (41:27):And I think it's very unfortunately being to support other goals and other ends forgetting about the fact that science is an ongoing process that science takes steps back when it needs to revise its position, that it still continues to be true, that s science progresses through self-correction. Even if that self-correction doesn't happen overnight, it takes time to realize that a correction is required, takes time to evaluate judiciously that correction is required and what kind of correction is required, right? These are the things that of course, you and I know very well. But the, sometimes if for individuals who are not close to the process of how science research fact-based discovery is conducted, if you just look at information on social media or in general media, you may walk away with an impression that science is not worth paying attention to that science is in some deep crisis.Magdalena Skipper (43:04):And I think that's, that's a shame that that's a picture that we have other things that need other things in science, in research that need correcting, that need sorting out. Of course, we mustn't forget that research is done by humans and, and after all it is human to air. But overall, that's actually something that keeps me up at night. That overall, I really hope that those of us who are engaged in one way or another within the research enterprise, we can continue to advance the right kind of image that it's not perfect in some artificial way, but actually, at the same time, it's the only way that we can move forward. We can understand the world around us, and we can wake, make the world around us better, actually.Eric Topol (44:11):Yeah. I'm so glad you've emphasized this because just like we talked earlier about distinguishing between human and AI content generated here, we have science and anti-science blurring facts, blurring truths, and basically taking down science as a search for truth and making it trying to, you know, obscure its mission and, in many ways, we, we saw it with not just anti-vax, but it's much bigger. The political motives are obvious extraordinary, particularly as we see here in the U.S. but other countries as well. So I almost didn't hit you for that question, just because it's so profound. We don't have the answers, but the fact that you're thinking about it tells, tells us all a lot. So Magdalena, this has been a joy. I really appreciate all your candid and very thoughtful responses to some of these questions.(45:09):Some of them pretty tough questions I have to say. And I look forward to our conversations and chances to visit with you again in the future. And congratulations again on taking on the leadership of Nature for five years now-- I believe just past your five-year anniversary now. You could say that's small out of 155 years, but I think it's a lot. particularly since the last few years have been, you really challenging. But to you and your team ultimately –-major kudos. I'm on the Nature website every single day. I mean, even, I when I'm on vacation, I'll be checking out the Nature site. So you can tell that I think so highly of the its content and we'll look forward to future conversations going forward.Magdalena Skipper (45:52):Thank you very much. Thank you very much, Eric. It's always a pleasure to talk to you. Thank you. Get full access to Ground Truths at erictopol.substack.com/subscribe

Tracklist: 00:00 | 00. Intro 01:35 | 01. Atmozfears & Devin Wild - Long Way Home 04:49 | 02. Audiotricz, Ecstatic featuring MERYLL - In Our Heads 07:40 | 03. Wildstylez featuring E-Life and Noah Jacobs - One 10:39 | 04. Bass Modulators - Sun Goes Down 13:10 | 05. Da Tweekaz & Frontliner - Never Far 16:37 | 06. Headhunterz Feat. TATU - Colors 18:47 | 07. Festuca - Pressure Waves 21:22 | 08. Adronity & High Level ft. TNYA - Dream Of Reality 24:25 | 09. Coone - Dance With My Demons 27:15 | 10. Phuture Noize featuring Daimy Lotus - Thru the Smoke 30:30 | 11. Rebelion and Atilax - Rebels Of Shutdown (Shutdown Festival 2023 Anthem) 34:41 | 12. Bass X Machina & REVIVE ft. Ava Silver - Transcend 38:30 | 13. Boray - Get Loose 41:00 | 14. B-Front, MNO and DV8 - Echoes 44:46 | 15. E-Force & Frequencerz - Men Of Steel (Adaro & Level One Remix) 48:16 | 16. E-Force & Luna - Kicks Like This 51:24 | 17. Sefa - 1527 54:30 | 18. Angerfist - What Happened 56:52 | 19. The Prophet & Dr. Peacock - Killing No More

In this episode of the Epigenetics Podcast, we talked with Mary Gehring from MIT about her work on transgenerational inheritance and epigenetic imprinting in plants. Mary Gehring and her team are focusing on plant epigenetics and genetic imprinting in plants, studying DNA methylation in Arabidopsis. They have found significant differences in DNA methylation between the embryo and endosperm of plants, particularly in relation to imprinted genes. She also discusses their work on hydroxymethylcytosine (5-hmC) in Arabidopsis and the challenges of detecting and studying this epigenetic modification. Next, we discuss the regulatory circuit involving ROS1, a DNA glycosylase involved in demethylation, and its role in maintaining epigenetic homeostasis. The interview concludes with a discussion of CUT&RUN, which the lab has adapted for use in plants. Due to its low input requirements this method has been valuable in studying various plant tissues and has influenced Mary Gehring's research on imprinting in Arabidopsis endosperm.   References Gehring, M., Bubb, K. L., & Henikoff, S. (2009). Extensive demethylation of repetitive elements during seed development underlies gene imprinting. Science (New York, N.Y.), 324(5933), 1447–1451. https://doi.org/10.1126/science.1171609 Pignatta, D., Erdmann, R. M., Scheer, E., Picard, C. L., Bell, G. W., & Gehring, M. (2014). Natural epigenetic polymorphisms lead to intraspecific variation in Arabidopsis gene imprinting. eLife, 3, e03198. https://doi.org/10.7554/eLife.03198 Klosinska, M., Picard, C. L., & Gehring, M. (2016). Conserved imprinting associated with unique epigenetic signatures in the Arabidopsis genus. Nature plants, 2, 16145. https://doi.org/10.1038/nplants.2016.145 Zheng, X. Y., & Gehring, M. (2019). Low-input chromatin profiling in Arabidopsis endosperm using CUT&RUN. Plant reproduction, 32(1), 63–75. https://doi.org/10.1007/s00497-018-00358-1   Related Episodes The Role of Small RNAs in Transgenerational Inheritance in C. elegans (Oded Rechavi) Epigenetic Influence on Memory Formation and Inheritance (Isabelle Mansuy) The Epigenetics of Human Sperm Cells (Sarah Kimmins)   Contact Epigenetics Podcast on Twitter Epigenetics Podcast on Instagram Epigenetics Podcast on Mastodon Active Motif on Twitter Active Motif on LinkedIn Email: podcast@activemotif.com

This month we look at a method to raise the bar on the quality and trustworthiness of information shared over social media networks, how fish running a fever heal from infection faster, what miniature bat backpacks can reveal about the eating and hunting habits of our flying mammalian cousins, how kingfishers come by their plumage patterns, and the evolution of spider venom genes. Join Dr Chris Smith for a look inside the science at eLife... Get the references and the transcripts for this programme from the Naked Scientists website

The Be More Today Show is back with a special episode looking at the Athletic brain. Check out my conversation with fellow Brown Alumna and life-long athlete Dr. Allison Brager. Dr. Allison Brager is the Chief Science Officer of the John F. Kennedy Special Warfare Center and School. She is the recipient of two National Research Service Awards from the National Institutes of Health and a National Academies of Sciences Fellowship to study physiological resiliency in extreme environments. Dr. Brager's work spans from clinical drug trials to applied field studies with elite athletes, combat divers, and Special Forces in some of the most austere places on earth to include Antarctica. In 2020, Dr. Brager underwent astronaut assessment & selection at NASA.   She sits on advisory boards for the NCAA, NATO, Special Operations Command, the Office of the Army Surgeon General, and the federal government. She is the recipient of two presidential Meritorious Service Medals and a Joint Commendation Medal for her clinical and research expertise during the COVID-19 pandemic and the War on Terrorism. Dr. Brager has > 40 peer-reviewed publications in flagship journals to include Science, eLife, Journal of Neuroscience, and Neuropsychopharmacology and is author of Meathead: Unraveling the Athletic Brain. She holds an Sc.B in Psychology from Brown University and a Ph.D in Physiology from Kent State University. www.bemoretoday.com --- Send in a voice message: https://podcasters.spotify.com/pod/show/bemoretoday/message Support this podcast: https://podcasters.spotify.com/pod/show/bemoretoday/support

In this episode of the Epigenetics Podcast, we caught up with Luciano Di Croce from the Center of Genomic Regulation in Barcelona to talk about his work on epigenetic landscapes in cancer. The Di Croce Lab focuses on the Polycomb Complex and its influence on diseases like cancer. Luciano Di Croce started out his research career investigating the oncogenic transcription factor PML-RAR. They could show that in leukemic cells knockdown of SUZ12, a key component of Polycomb repressive complex 2 (PRC2), reverts not only histone modification but also induces DNA de-methylation of PML-RAR target genes. More recently the team focused on two other Polycomb related proteins Zrf1 and PHF19 and were able to characterize some of their functions in gene targeting in different disease and developmental contexts.   References Di Croce, L., Raker, V. A., Corsaro, M., Fazi, F., Fanelli, M., Faretta, M., Fuks, F., Lo Coco, F., Kouzarides, T., Nervi, C., Minucci, S., & Pelicci, P. G. (2002). Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor. Science (New York, N.Y.), 295(5557), 1079–1082. https://doi.org/10.1126/science.1065173 Richly, H., Rocha-Viegas, L., Ribeiro, J. D., Demajo, S., Gundem, G., Lopez-Bigas, N., Nakagawa, T., Rospert, S., Ito, T., & Di Croce, L. (2010). Transcriptional activation of polycomb-repressed genes by ZRF1. Nature, 468(7327), 1124–1128. https://doi.org/10.1038/nature09574 Jain, P., Ballare, C., Blanco, E., Vizan, P., & Di Croce, L. (2020). PHF19 mediated regulation of proliferation and invasiveness in prostate cancer cells. eLife, 9, e51373. https://doi.org/10.7554/eLife.51373   Related Episodes Oncohistones as Drivers of Pediatric Brain Tumors (Nada Jabado) Transcription and Polycomb in Inheritance and Disease (Danny Reinberg) Targeting COMPASS to Cure Childhood Leukemia (Ali Shilatifard)   Contact Epigenetics Podcast on Twitter Epigenetics Podcast on Instagram Epigenetics Podcast on Mastodon Active Motif on Twitter Active Motif on LinkedIn Email: podcast@activemotif.com

In this episode of the Epigenetics Podcast, we caught up with Ines Drinnenberg from Institute Curie to talk about her work on the formation of CenH3-deficient kinetochores. The laboratory of Ines Drinneberg focuses on centromeres and how different strategies of centromere organization have evolved in different organisms. While most eukaryotes have monocentric chromosomes, where spindle attachment is restricted to a single chromosomal region resembling such classic X-shape like structures under the microscope, many lineages have evolved holocentric chromosomes where spindle microtubules attach along the entire length of the chromosome. The team was able to show the independent loss of CENH3/CENP-A in holocentric insects. Furthermore, the team focuses on how CenH3-deficient kinetochores form and were able to identify several conserved kinetochore components that emerged as a key component for CenH3-deficient kinetochore formation in Lepidoptera.   References Drinnenberg, I. A., deYoung, D., Henikoff, S., & Malik, H. S. (2014). Recurrent loss of CenH3 is associated with independent transitions to holocentricity in insects. eLife, 3, e03676. https://doi.org/10.7554/eLife.03676 Molaro, A., & Drinnenberg, I. A. (2018). Studying the Evolution of Histone Variants Using Phylogeny. Methods in molecular biology (Clifton, N.J.), 1832, 273–291. https://doi.org/10.1007/978-1-4939-8663-7_15 Cortes-Silva, N., Ulmer, J., Kiuchi, T., Hsieh, E., Cornilleau, G., Ladid, I., Dingli, F., Loew, D., Katsuma, S., & Drinnenberg, I. A. (2020). CenH3-Independent Kinetochore Assembly in Lepidoptera Requires CCAN, Including CENP-T. Current biology : CB, 30(4), 561–572.e10. https://doi.org/10.1016/j.cub.2019.12.014 Senaratne, A. P., Muller, H., Fryer, K. A., Kawamoto, M., Katsuma, S., & Drinnenberg, I. A. (2021). Formation of the CenH3-Deficient Holocentromere in Lepidoptera Avoids Active Chromatin. Current biology : CB, 31(1), 173–181.e7. https://doi.org/10.1016/j.cub.2020.09.078 Vanpoperinghe, L., Carlier-Grynkorn, F., Cornilleau, G., Kusakabe, T., Drinnenberg, I. A., & Tran, P. T. (2021). Live-cell imaging reveals square shape spindles and long mitosis duration in the silkworm holocentric cells. microPublication biology, 2021, 10.17912/micropub.biology.000441. https://doi.org/10.17912/micropub.biology.000441   Related Episodes The Role of Non-Histone Proteins in Chromosome Structure and Function During Mitosis (Bill Earnshaw) Chromatin Profiling: From ChIP to CUT&RUN, CUT&Tag and CUTAC (Steven Henikoff) In Vivo Nucleosome Structure and Dynamics (Srinivas Ramachandran)   Contact Epigenetics Podcast on Twitter Epigenetics Podcast on Instagram Epigenetics Podcast on Mastodon Active Motif on Twitter Active Motif on LinkedIn Email: podcast@activemotif.com

JOURNEY TO TRUTH 2023 CONFERENCE Grafton, Illinois May 22 - 25 - GET YOUR TICKET TODAY! https://www.journeytotruthcon.com/ Our website: https://www.journeytotruthpodcast.com/ Donate: https://donorbox.org/donate-to-jttp Thank you

VIDEOS: Dem Party Turns On Anti-War Democratic Primary Winner (2:16 to 5:28) Society is going to COLLAPSE -Neil Oliver ( 5:24) Fear Psychosis and the Cult of Safety – Why are People so Afraid?  – Academy of Ideas (13:25) The Great Reset and Transhumanism | Beyond the Cover (17:50)   Zinc supplementation associated with higher levels of brain growth factor Soybean foods may protect menopausal women against osteoporosis Study finds diet high in saturated fat can reprogram immune cells in mice Coenzyme Q10 consumption reverses cholesterol transport Study confirms that processed foods key to rising obesity Violence on TV: Effects from age 3 can stretch into the teen years Zinc supplementation associated with higher levels of brain growth factor Iran University of Medical Sciences, November 4 2022.  A review and meta-analysis of randomized, controlled trials affirmed an association between supplementing with zinc and higher circulating levels of brain-derived neurotrophic factor (BDNF). Brain-derived neurotrophic factor plays a positive role in the survival of brain cells known as neurons. A reduction in BDNF expression occurs in Alzheimer and Parkinson diseases, multiple sclerosis and amyotrophic lateral sclerosis. Antidepressants and anthocyanin supplements have been shown to increase BDNF gene expression, and serum or plasma levels have been elevated by exercise and omega-3 fatty acid, resveratrol or zinc supplementation. For their review and meta-analysis, Fahimeh Agh of Iran University of Medical Sciences and colleagues identified four trials that evaluated the effects of zinc supplements on serum or plasma BDNF levels among 185. Zinc dosages ranged from 25–30 milligrams per day given for 84–90 days.  Pooled results of the trials found significantly higher BDNF levels among participants who received zinc compared with participants in the control groups. The increase in BDNF was significant at 30 milligram doses (which were used in 3 trials) and at all trial durations. Among the 3 trials that analyzed serum zinc levels, participants who were given zinc supplements had significantly increased zinc levels in comparison with the control participants.  “A large body of evidence indicated BDNF as an important predictive factor for following the beginning, progress and cure of brain disorders due to its main role in brain neurogenesis and neuroplasticity,” Agh and her associates wrote.  “Increased circulating levels of BDNF as a result of zinc supplementation suggest that zinc supplementation may be a safe and effective strategy to counteract neurodegenerative diseases that are correlated with low BDNF levels,” they concluded. Soybean foods may protect menopausal women against osteoporosis  University of Hull (UK), November 1, 2022 Eating a diet rich in both soy protein and isoflavones can protect menopausal women from bone weakening and osteoporosis, according to the results of a preliminary study presented today at the Society for Endocrinology annual conference in Edinburgh. Soybean foods contain chemicals known as isoflavones that are similar in structure to oestrogen and so could theoretically protect women against osteoporosis by mimicking the action of oestrogen. In this study, researchers from the University of Hull gave two hundred women in early menopause a daily supplement containing soy protein with 66mg of isoflavones or a supplement with soy protein alone for six months. The researchers investigated changes in the women's bone activity by measuring certain proteins (βCTX and P1NP) in their blood.  They found that the women on the soy diet with isoflavones had significantly lower levels of βCTX than the women on soy alone, suggesting that their rate of bone loss was slowing down and lowering their risk of developing osteoporosis. Women taking soy protein with isoflavones were also found to have decreased risk of cardiovascular disease than those taking soy alone. “The 66 mg of isoflavone that we use in this study is equivalent to eating an oriental diet, which is rich in soy foods. In contrast, we only get around 2-16 mg of isoflavone with the average western diet.” “Supplementing our food with isoflavones could lead to a significant decrease in the number of women being diagnosed with osteoporosis.” Study finds diet high in saturated fat can reprogram immune cells in mice Portland State University, November 7, 2022 A new study by Portland State University researchers is the first to show that eating a diet exclusively high in saturated fats can reprogram the mouse immune system, making it better able to fight off infection but more susceptible to systemic inflammatory conditions, including sepsis. Brooke Napier, assistant professor of biology at PSU, led the study, which was published in eLife. The ketogenic or “keto” diet is a popular high-fat diet used for weight loss or to control epileptic seizures. This study shows that when mice eat a ketogenic diet that is high in saturated fats it can have a significant impact on their immune system.  A previous study by Napier and colleagues found that mice fed a high-fat, high-sugar Western diet were more susceptible to sepsis and had a higher mortality rate than mice fed a standard diet. In the current study, the researchers found similar effects in mice fed a high-fat ketogenic diet, suggesting that dietary fat may play a role in sepsis.  The researchers focused on one particular fat found in the blood of the mice fed a ketogenic diet: palmitic acid, which is commonly found in animal fats and dairy products. Remarkably, mice fed a normal diet who were injected with palmitic acid also became more susceptible to sepsis.  “It was just exposure to this one saturated fat that made them more susceptible to sepsis mortality,” says Napier. “The idea that you could have a specific fat in your diet that would cause such a drastic outcome in disease is kind of incredible.”  Napier and her team next probed just how exactly high levels of palmitic acid could initiate sepsis. Their first clue came when they noticed that mice fed the Western diet, mice fed the ketogenic diet, and mice treated with palmitic acid all had high levels of inflammatory cytokines, immunological hormones that can cause fever and systemic inflammation during sepsis.  The presence of the inflammatory cytokines suggested that palmitic acid could be affecting the immune system by causing inflammation, but Napier soon discovered that the story was more complicated—and more interesting—than that. Napier and colleagues also found that another type of fat may be able to counteract the harmful effects of palmitic acid. Oleic acid, a polyunsaturated fat found in many plant-based oils including olive oil, can block the synthesis of ceramide, a fatty substance that can initiate a stress response in cells and may play a role in the hyperinflammatory response that causes sepsis. When the researchers fed mice a ketogenic diet for two weeks but also gave them oleic acid for the final three days, they no longer showed an increased susceptibility to sepsis. Coenzyme Q10 consumption reverses cholesterol transport Sun Yat Sen University (Taiwan), October 31, 2022 According to news reporting out of Guangdong, People's Republic of China, research stated, “We have recently shown that coenzyme Q10 (CoQ10) enhances macrophage reverse cholesterol transport via activator protein-1/miRNA-378/ABCG1 signal pathway in vivo and in vitro. Whether CoQ10 exerts similar beneficial effects in human is currently unknown.” Our news journalists obtained a quote from the research from Sun Yat Sen University, “The present study evaluated the effect of CoQ10 on ABCG1-mediated macrophage cholesterol efflux in 20 healthy volunteers. Participants were given 100 mg CoQ10 twice daily or placebo for 1 week with a 1-week washout period. Human monocyte-derived macrophages (MDMs) were differentiated under pooled sera obtained before (preCoQ10) or after CoQ10 (postCoQ10) consumption. The CoQ10-induced inhibition of MDMs foam cell formation was blocked by ABCG1 silencing in postCoQ10 MDMs incubated with postCoQ10 sera compared to preCoQ10 sera. The cholesterol efflux to HDL, and mRNA as well as protein expressions of ATP-binding cassette transporter G1 (ABCG1) were augmented in postCoQ10 MDMs incubated with postCoQ10 sera compared to preCoQ10 sera. The change in the serum CoQ10 concentration positively correlated with cholesterol efflux to HDL and ABCG1 mRNA level in the CoQ10 group. MDMs treated with purified CoQ10 had an enhanced cholesterol efflux to HDL.” According to the news editors, the research concluded: “CoQ10 consumption may have an atheroprotective property by inducing ABCG1 expression and enhancing HDL-mediated macrophage cholesterol efflux in healthyindividuals.” Study confirms that processed foods key to rising obesity University of Sydney (Australia), November 7, 2022 A year-long study of the dietary habits of 9,341 Australians has backed growing evidence that highly processed and refined foods are the leading contributor of rising obesity rates in the Western world. “As people consume more junk foods or highly processed and refined foods, they dilute their dietary protein and increase their risk of being overweight and obese, which we know increases the risk of chronic disease,” said lead author Dr. Amanda Grech, a Postdoctoral Research Fellow at the CPC and the university's School of Life and Environmental Sciences. “It's increasingly clear that our bodies eat to satisfy a protein target,” added Professor David Raubenheimer, the Leonard Ullmann Chair in Nutritional Ecology at the School of Life and Environmental Sciences. “But the problem is that the food in Western diets has increasingly less protein. So, you have to consume more of it to reach your protein target, which effectively elevates your daily energy intake. The University of Sydney scientists analyzed data from a cross-sectional survey of nutrition and physical activity in 9,341 adults, known as the National Nutrition and Physical Activity Survey with a mean age of 46.3 years. They found the population's mean energy intake was 8,671 kilojoules (kJ), with the mean percentage of energy from protein being just 18.4 percent, compared with 43.5 percent from carbohydrates and from 30.9 percent from fat, and just 2.2 percent from fiber and 4.3 percent from alcohol. They also found a statistically significant difference between groups by the third meal of the day: those with a higher proportion of energy from protein at the start of the day had much lower total energy intake for the day. Meanwhile, those who consumed foods low in protein at the start of the day proceeded to increase consumption, indicating they were seeking to compensate with a higher consumption of overall energy. This is despite the fact the first meal was the smallest for both groups, with the least amount of energy and food consumed, whereas the last meal was the largest. Participants with a lower proportion of protein than recommended at the first meal consumed more discretionary foods—energy-dense foods high in saturated fats, sugars, salt, or alcohol—throughout the day, and less of the recommended five food groups (grains; vegetables/legumes; fruit; dairy and meats). Consequently, they had an overall poorer diet at each mealtime, with their percentage of protein energy decreasing even as their discretionary food intake rose—an effect the scientists call ‘protein dilution'. While many factors contribute to excess weight gain—including eating patterns, physical activity levels, and sleep routines—the University of Sydney scientists argue the body's powerful demand for protein, and its lack in highly processed and refined foods, is a key driver of energy overconsumption and obesity in the Western world. Violence on TV: Effects from age 3 can stretch into the teen years University of Montreal, November 7, 2022 Watching violent TV during the preschool years can lead to later risks of psychological and academic impairment by the summer before middle school starts, according to a new study led by Linda Pagani, a professor at Université de Montréal's School of Psycho-Education. Before now, “it was unclear to what extent exposure to typical violent screen content in early childhood—a particularly critical time in brain development—can predict later psychological distress and academic risks,” said Pagani. “The detection of early modifiable factors that influence a child's later well-being is an important target for individual and community health initiatives, and psychological adjustment and academic motivation are essential elements in the successful transition to adolescence,” she added. “So, we wanted to see the long-term effect of typical violent screen exposure in preschoolers on normal development, based on several key indicators of youth adjustment at age 12.” To do this, Pagani and her team examined the violent screen content that parents reported their children viewing between ages 3 1/2 and 4 1/2, and then conducted a follow-up when the children reached age 12. “Compared to their same-sex peers who were not exposed to violent screen content, boys and girls who were exposed to typical violent content on television were more likely to experience subsequent increases in emotional distress,” said Pagani. “They also experienced decreases in classroom engagement, academic achievement and academic motivation by the end of the sixth grade,” she added. “For youth, transition to middle school already represents a crucial stage in their development as adolescents. Feeling sadness and anxiety and being at risk academically tends to complicate their situation.” In all, the parents of 978 girls and 998 boys participated in the study of violent TV viewing at the preschool age. At age 12 years, the children and their teachers rated the children's psychosocial and academic achievement, motivation and participation in classroom activities. “Preschool children tend to identify with characters on TV and treat everything they see as real,” Pagani said. “They are especially vulnerable to humorous depictions of glorified heroes and villains who use violence as a justified means to solve problems. “Repeated exposure,” she added, “to rapidly paced, adrenaline-inducing action sequences and captivating special effects could reinforce beliefs, attitudes and impressions that habitual violence in social interactions is ‘normal.' Mislearning essential social skills can make it difficult to fit in at school.” Added Bernard, “Just like witnessing violence in real life, being repeatedly exposed to a hostile and violent world populated by sometimes grotesque-looking creatures could trigger fear and stress and lead these children to perceive society as dangerous and frightening. And this can lead to habitually overreacting in ambiguous social situations. In the preschool years, the number of hours in a day is limited, and the more children get exposed to aggressive interactions (on screens) the more they might think it normal to behave that way.”

Today, you'll learn about mushrooms that can eat asteroids to make space soil, how our thoughts affect us as we microdose psychedelics, and efforts to 3D print organs like kidneys and lungs!Hungry mushrooms.Fungi Could Make Soil From Asteroids and Homes on Mars by Madeleine Gregoryhttps://www.discovermagazine.com/the-sciences/fungi-could-make-soil-from-asteroids-and-homes-on-marsMaking Soil for Space Habitats by Seeding Asteroids with Fungi by Jane Shevtsovhttps://www.nasa.gov/directorates/spacetech/niac/2021_Phase_I/Making_Soil_for_Space_Habitats/Could Future Homes on the Moon and Mars Be Made of Fungi? by Frank Tavareshttps://www.nasa.gov/feature/ames/myco-architectureFuture Space Travel Might Require Mushrooms by Nick Hildenhttps://www.scientificamerican.com/article/space-travels-most-surprising-future-ingredient-mushrooms/Far out thoughts.Citizen Scientists Show Placebo Effect May Explain Benefits of Microdosing by Ryan O'harehttps://www.imperial.ac.uk/news/216134/citizen-scientists-show-placebo-effect-explain/Self-Blinding Citizen Science to Explore Psychedelic Microdosing by Balázs Szigeti, et al.https://doi.org/10.7554/eLife.62878What to Know About Microdosing LSD by Medical News Todayhttps://www.medicalnewstoday.com/articles/microdosing-lsdPsychedelic Microdosing Benefits and Challenges: An Empirical Codebook by Thomas Anderson, et al.https://doi.org/10.1186/s12954-019-0308-4A different kind of printer.“When we'll be able to 3D-print organs and who will be able to afford them” by Kristen Rogershttps://www.cnn.com/2022/06/10/health/3d-printed-organs-bioprinting-life-itself-wellness-scn/index.html“Advanced Polymers for Three-Dimensional (3D) Organ Bioprinting” by Xiaohong Wang.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952999/#:~:text=Three%2Ddimensional%20(3D)%20organ%20bioprinting%20is%20the%20utilization%20of,7%2C8%2C9%5DFollow Curiosity Daily on your favorite podcast app to get smarter with Calli and Nate — for free! Still curious? Get exclusive science shows, nature documentaries, and more real-life entertainment on discovery+! Go to https://discoveryplus.com/curiosity to start your 7-day free trial. discovery+ is currently only available for US subscribers.Find episode transcripts here: https://curiosity-daily-4e53644e.simplecast.com/episodes/asteroid-eating-fungi-psychedelicmaybe-printing-organs