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On this episode, Chris welcomes acclaimed American abstract artist Galen Cheney for an insightful conversation about creativity, artistic exploration, and the evolving language of contemporary abstract painting. Known for her vibrant, expressive works and fearless approach to experimentation, Galen Cheney has built a distinguished career creating paintings that balance intuition, movement, color, and emotion. Her work invites viewers into a visual dialogue where meaning emerges through process, gesture, and personal interpretation rather than representation alone. In this engaging discussion, Galen shares her artistic journey, the experiences that shaped her creative voice, and how abstraction allows her to explore ideas that cannot always be expressed through words. She discusses the role of curiosity in her studio practice, the challenges and rewards of maintaining a long-term creative career, and how embracing uncertainty often leads to artistic breakthroughs.Whether you're an artist, collector, student, or simply fascinated by the creative process, this episode offers a compelling look inside the mind of one of today's accomplished abstract painters. Galen Cheney's thoughtful reflections on creativity, artistic growth, and the pursuit of authentic expression provide inspiration for anyone seeking to deepen their understanding of contemporary art. AART is the podcast where host Chris Stafford engages in meaningful conversations with artists, creators, and cultural voices from around the world, exploring the stories, challenges, and inspirations behind their work.Subscribe to AART for more conversations with leading artists, painters, photographers, sculptors, filmmakers, and creative innovators shaping today's artistic landscape. Galen's website: https://www.galencheney.com/Instagram: https://www.instagram.com/galenwcheney/ Some of Galen's favorite female artists:Joan SnyderPat SteirJulie MehretuAmy SillmanCharlene von HeylCecily BrownMarie ThiebaultTerry EkasalaKim ManfrediDeborah DancyMie YimAstrid Dick Galen's dinner party guests:Joan MitchellGrace HartiganHelen FrankenthalerLee KrasnerElaine De KoonigArtemisia GentileschiSEO Keywords:Galen Cheney, Galen Cheney artist, abstract artist, American abstract artist, contemporary abstract art, abstract painting, contemporary painter, modern art, fine art podcast, artist interview, creative process, abstract expressionism, contemporary painting, women artists, visual arts, painting techniques, studio practice, color theory, intuitive painting, expressive painting, contemporary artist interview, art podcast, AART podcast, Chris Stafford, Women Unscripted Podcast Network, abstract art inspiration, professional artist, fine art collector, modern painter, creative journey, artistic process, contemporary art conversation, American painter, visual artist, creativity and art, contemporary art world. Become a supporter of this podcast: https://www.spreaker.com/podcast/aart--5814675/support.Hollowell Studios ProductionWebsite: https://hollowellstudios.com/podcastsInstagram: @theaartpodcast Email: theaartpodcast@gmail.com© Copyright: Chris Stafford | Hollowell StudiosAll Rights Reserved
Abstract: Alma 16 is an easily overlooked chapter in the Book of Mormon. It could be dismissed as a simple summary and “tidying up” of the narrative. It comes after two of the most dramatic scenes in the Book of Mormon, wherein women and children are burned to death in Ammonihah and Alma and Amulek are miraculously delivered from prison. It also directly precedes the account of the sons of Mosiah journeying to Lamanite lands to preach the gospel. However—as is the case with other chapters in the book of Alma that serve to summarize and conclude large sections of the text—Alma 16 is carefully developed, highly structured, and beautifully written. In this article, I will analyze the literary structure of Alma 16, which is composed of two major literary units. Both units are structured as chiasms in which the matching units share many strong links and parallels. These two chiasms also work together to engage the reader with striking parallels and dramatic contrasts. Alma 16, being the concluding chapter of Alma's missionary efforts among the Nephites, reveals a particular splendor and distinction. The two main chiastic structures help with the exegesis of these verses by highlighting significant yet potentially underappreciated features. The post The Literary Structure of Alma 16 first appeared on The Interpreter Foundation.
Deep Energy 2.0 - Music for Sleep, Meditation, Relaxation, Massage and Yoga
Background Music for Sleep, Meditation, Relaxation, Massage, Yoga, Studying and Therapy - Deep Energy 2427 - 2429 - Abstract Soundscapes - Parts 1 - 3 This was originally Deep Energy 1480 and has been remastered. I am taking a little vacation and remastering and re-releasing some of the older podcasts. Enjoy!! AD FREE VERSIONS OF ALL THE PODCASTS ARE HERE: www.jimbutler.bandcamp.com …… Please remember to turn on automatic downloads, like and subscribe, tell a friend, share with your family and leave a review. All of those things help build the podcast. Thank you so much!! ………. This podcast is ad supported. We try the best we can to keep all of the ads at the front and the back of the podcast, but depending on the length of the podcast, there maybe ads in the middle. Please check my Bandcamp page for ad free podcasts. www.jimbutler.bandcamp.com ……………………….. Watch me play live on TikTok @jimbutlermusic or On the Insight Timer App as Jim Butler Links for all of the podcasts in the Deep Energy Podcast Network: Deep Energy Podcast (Current Episodes) https://podcasts.apple.com/us/podcast/deep-energy-podcast-music-for-sleep-meditation-yoga/id511265415 https://open.spotify.com/show/1DhN56DzDKc0FhQqR23v9c Deep Energy Classics - All of the ORIGINAL Episodes https://podcasts.apple.com/us/podcast/deep-energy-classics-original-episodes/id1734274408 https://www.spreaker.com/podcast/deep-energy-classics-original-episodes--6108618 https://open.spotify.com/show/7BjEFnqcyKWUkHcYdtFS25?si=05aeab39b5bc4a00 Deep Energy Daily Affirmations - Daily Affirmations to get you through the day https://podcasts.apple.com/us/podcast/deep-energy-daily-affirmations/id1729162791 https://open.spotify.com/show/0oaA8dRsWDQLkqeXmykGvu?si=461c7b47417b4e55 Deep Energy Guided Meditations - Guided Meditations to help through your day https://podcasts.apple.com/us/podcast/deep-energy-guided-meditations-with-michelle-davis-jim/id1732674561 https://open.spotify.com/show/1Kg2LTaFux10Ul94phybp8?si=ebbbf33757d64c13 https://www.spreaker.com/podcast/deep-energy-guided-meditations-with-michelle-davis-jim-butler--6098026 Slow Piano for Sleep - Solo Piano Pieces https://podcasts.apple.com/us/podcast/slow-piano-for-sleep-music-for-sleep-meditation-and/id1626828397 https://www.spreaker.com/podcast/slow-piano-for-sleep-music-for-sleep-meditation-and-relaxation--5572963 ………… www,jimbutlermusic.com jimbutlermusic@gmail.com All Social Media (FB - IG - YT - TT) is: @jimbutlermusic Merch: www.deepenergy.threadless.com Bandcamp Monthly No Ads Subscription/Patreon: www.jimbutler.bandcamp.com Custom Made Music: jimbutlermusic@gmail.com ………………….. Thank you for listening. All music is created, performed and composed by Jim Butler. AI IS NEVER USED TO CREATE MY MUSIC. Until the next time, please be kind to one another, peace, bye… …….. Original Image by the Dream App (not sponsored) or Canva (not sponsored) or Midjourney (not Sponsored) …………………. Become a supporter of this podcast: https://www.spreaker.com/podcast/deep-energy-podcast-music-for-sleep-meditation-yoga-background-music-and-studying--4262945/support.
Deep Energy 2.0 - Music for Sleep, Meditation, Relaxation, Massage and Yoga
Background Music for Sleep, Meditation, Relaxation, Massage, Yoga, Studying and Therapy - Deep Energy 2427 - 2429 - Abstract Soundscapes - Parts 1 - 3 This was originally Deep Energy 1480 and has been remastered. I am taking a little vacation and remastering and re-releasing some of the older podcasts. Enjoy!! AD FREE VERSIONS OF ALL THE PODCASTS ARE HERE: www.jimbutler.bandcamp.com …… Please remember to turn on automatic downloads, like and subscribe, tell a friend, share with your family and leave a review. All of those things help build the podcast. Thank you so much!! ………. This podcast is ad supported. We try the best we can to keep all of the ads at the front and the back of the podcast, but depending on the length of the podcast, there maybe ads in the middle. Please check my Bandcamp page for ad free podcasts. www.jimbutler.bandcamp.com ……………………….. Watch me play live on TikTok @jimbutlermusic or On the Insight Timer App as Jim Butler Links for all of the podcasts in the Deep Energy Podcast Network: Deep Energy Podcast (Current Episodes) https://podcasts.apple.com/us/podcast/deep-energy-podcast-music-for-sleep-meditation-yoga/id511265415 https://open.spotify.com/show/1DhN56DzDKc0FhQqR23v9c Deep Energy Classics - All of the ORIGINAL Episodes https://podcasts.apple.com/us/podcast/deep-energy-classics-original-episodes/id1734274408 https://www.spreaker.com/podcast/deep-energy-classics-original-episodes--6108618 https://open.spotify.com/show/7BjEFnqcyKWUkHcYdtFS25?si=05aeab39b5bc4a00 Deep Energy Daily Affirmations - Daily Affirmations to get you through the day https://podcasts.apple.com/us/podcast/deep-energy-daily-affirmations/id1729162791 https://open.spotify.com/show/0oaA8dRsWDQLkqeXmykGvu?si=461c7b47417b4e55 Deep Energy Guided Meditations - Guided Meditations to help through your day https://podcasts.apple.com/us/podcast/deep-energy-guided-meditations-with-michelle-davis-jim/id1732674561 https://open.spotify.com/show/1Kg2LTaFux10Ul94phybp8?si=ebbbf33757d64c13 https://www.spreaker.com/podcast/deep-energy-guided-meditations-with-michelle-davis-jim-butler--6098026 Slow Piano for Sleep - Solo Piano Pieces https://podcasts.apple.com/us/podcast/slow-piano-for-sleep-music-for-sleep-meditation-and/id1626828397 https://www.spreaker.com/podcast/slow-piano-for-sleep-music-for-sleep-meditation-and-relaxation--5572963 ………… www,jimbutlermusic.com jimbutlermusic@gmail.com All Social Media (FB - IG - YT - TT) is: @jimbutlermusic Merch: www.deepenergy.threadless.com Bandcamp Monthly No Ads Subscription/Patreon: www.jimbutler.bandcamp.com Custom Made Music: jimbutlermusic@gmail.com ………………….. Thank you for listening. All music is created, performed and composed by Jim Butler. AI IS NEVER USED TO CREATE MY MUSIC. Until the next time, please be kind to one another, peace, bye… …….. Original Image by the Dream App (not sponsored) or Canva (not sponsored) or Midjourney (not Sponsored) …………………. Become a supporter of this podcast: https://www.spreaker.com/podcast/deep-energy-podcast-music-for-sleep-meditation-yoga-background-music-and-studying--4262945/support.
Joff Lacey and Imogen Fecher-Jones interview six oral abstract finalists at this years' EBPOM. Nora Cruz Rodriguez; Association Between Participation in Remote Prehabilitation and High-Dependency Unit Length of Stay After Oesophagectomy and Radical Cystectomy: A Retrospective Cohort. Alexios Dosis; Remote wearable monitoring as a preoperative risk assessment tool. Ned Douglas; The Fluids, Atomoxetine or Midodrine (FAME) pilot trial. Tom Scodellaro; The new normal: CPET findings in patients aged 80 years and older. Gerry O'Callaghan; Preventing and Reducing Re-Presentations and Admissions following surgery, new thinking required. Sandy (Alexander) Jackson; Cost of Radial Arterial Line Placement in UK Operating Theatres. -- The 2026 International Practicum on Cardiopulmonary Exercise Testing will be held at the Balmer Lawn Hotel in Brockenhurst, UK, from September 16th to 18th this year. It is organised by iPOETTS , the international perioperative testing and training society. Come and join us at this premier educational event designed for clinicians, scientists, and healthcare professionals interested in sport, exercise, and perioperative medicine. This is an International Perioperative Testing and Training Society accredited event so when you attend you can get your iPOETTS accreditation, showing that you are a practitioner who has reached a high, standardized level of competence in performing and interpreting Cardiopulmonary Exercise Testing (CPET) for patients preparing for major surgery. Go now to http://www.ebpom.org
Deep Energy 2.0 - Music for Sleep, Meditation, Relaxation, Massage and Yoga
Background Music for Sleep, Meditation, Relaxation, Massage, Yoga, Studying and Therapy - Deep Energy 2427 - 2429 - Abstract Soundscapes - Parts 1 - 3 This was originally Deep Energy 1480 and has been remastered. I am taking a little vacation and remastering and re-releasing some of the older podcasts. Enjoy!! AD FREE VERSIONS OF ALL THE PODCASTS ARE HERE: www.jimbutler.bandcamp.com …… Please remember to turn on automatic downloads, like and subscribe, tell a friend, share with your family and leave a review. All of those things help build the podcast. Thank you so much!! ………. This podcast is ad supported. We try the best we can to keep all of the ads at the front and the back of the podcast, but depending on the length of the podcast, there maybe ads in the middle. Please check my Bandcamp page for ad free podcasts. www.jimbutler.bandcamp.com ……………………….. Watch me play live on TikTok @jimbutlermusic or On the Insight Timer App as Jim Butler Links for all of the podcasts in the Deep Energy Podcast Network: Deep Energy Podcast (Current Episodes) https://podcasts.apple.com/us/podcast/deep-energy-podcast-music-for-sleep-meditation-yoga/id511265415 https://open.spotify.com/show/1DhN56DzDKc0FhQqR23v9c Deep Energy Classics - All of the ORIGINAL Episodes https://podcasts.apple.com/us/podcast/deep-energy-classics-original-episodes/id1734274408 https://www.spreaker.com/podcast/deep-energy-classics-original-episodes--6108618 https://open.spotify.com/show/7BjEFnqcyKWUkHcYdtFS25?si=05aeab39b5bc4a00 Deep Energy Daily Affirmations - Daily Affirmations to get you through the day https://podcasts.apple.com/us/podcast/deep-energy-daily-affirmations/id1729162791 https://open.spotify.com/show/0oaA8dRsWDQLkqeXmykGvu?si=461c7b47417b4e55 Deep Energy Guided Meditations - Guided Meditations to help through your day https://podcasts.apple.com/us/podcast/deep-energy-guided-meditations-with-michelle-davis-jim/id1732674561 https://open.spotify.com/show/1Kg2LTaFux10Ul94phybp8?si=ebbbf33757d64c13 https://www.spreaker.com/podcast/deep-energy-guided-meditations-with-michelle-davis-jim-butler--6098026 Slow Piano for Sleep - Solo Piano Pieces https://podcasts.apple.com/us/podcast/slow-piano-for-sleep-music-for-sleep-meditation-and/id1626828397 https://www.spreaker.com/podcast/slow-piano-for-sleep-music-for-sleep-meditation-and-relaxation--5572963 ………… www,jimbutlermusic.com jimbutlermusic@gmail.com All Social Media (FB - IG - YT - TT) is: @jimbutlermusic Merch: www.deepenergy.threadless.com Bandcamp Monthly No Ads Subscription/Patreon: www.jimbutler.bandcamp.com Custom Made Music: jimbutlermusic@gmail.com ………………….. Thank you for listening. All music is created, performed and composed by Jim Butler. AI IS NEVER USED TO CREATE MY MUSIC. Until the next time, please be kind to one another, peace, bye… …….. Original Image by the Dream App (not sponsored) or Canva (not sponsored) or Midjourney (not Sponsored) …………………. Become a supporter of this podcast: https://www.spreaker.com/podcast/deep-energy-podcast-music-for-sleep-meditation-yoga-background-music-and-studying--4262945/support.
Abstract is evolving before your very eyes! In this new iteration, we're highliting guests' trajectories out of grad school, discussing everything from how they got into research to what they're up to now.Discussion Points & BuzzwordsGetting into academia for the wrong reasonsBrachytherapyMedical PhysicistsUltrasound ImagingTraining a Neural NetworkSoftware Development and ProgrammingStaring Into Buttholes: Canals & AperturesWhy Do People Stay in Academia?ConsultingWorking for a Start-Up in San FranciscoStarting a Jewelry BusinessBeing Strategic About Next StepsCheck out Nicole and James' Gold Jewelry Business:Website: Bijouterieminted.caHandle: @bijouterieminted (on all platforms)Outro Bass Riff Sampled From:https://youtube.com/watch?v=OTeS179yxToFollow AbstractInstagram: @abstractcastIf you or someone you know has completed a graduate degree and has moved away from academia, reach out by email to share that story:abstractcast@gmail.com
BUFFALO, NY — July 1, 2026 — A new #review was #published in Volume 18 of Aging on June 11, 2026, titled “Age-related dysfunctions of the neuroendocrine axes in nonhuman primates with depression-like and anxious behavior.” The review, dedicated to the late Dr. Mikhail (Misha) Blagosklonny, was written by Nadezhda D. Goncharova from the Kurchatov Complex of Medical Primatology, National Research Center “Kurchatov Institute,” Adler, Sochi, Russian Federation. As people grow older, their risk of developing stress-related disorders—including depression, metabolic disease, cardiovascular disease, cognitive decline, and neurodegenerative conditions—increases substantially. However, not everyone ages in the same way. Some individuals appear more resilient to stress, while others develop endocrine and metabolic disturbances that may accelerate aging and disease. Understanding the biological mechanisms behind these differences could help identify people at greater risk and support more personalized approaches to healthy aging. In this review, the author summarizes decades of experimental research investigating how aging affects two major neuroendocrine systems—the hypothalamic-pituitary-adrenal (HPA) axis and the hypothalamic-pituitary-thyroid (HPT) axis—in nonhuman primates displaying either typical adaptive behavior or depression-like and anxiety-like behavior. Because rhesus monkeys closely resemble humans in their physiology, endocrine function, and behavior, they provide a valuable translational model for studying age-related changes that are difficult to examine in people. The research shows that older monkeys with depression-like and anxiety-like behavior develop more pronounced dysfunction of the HPA axis than animals with standard behavior. These animals exhibited impaired negative feedback regulation, higher evening and nighttime cortisol levels, increased responses to acute stress, and greater activation of stress-related hormonal pathways. Together, these findings suggest impaired regulation of stress responses during aging. The review also describes important age-related alterations in thyroid function. Older animals with depression-like and anxiety-like behavior showed lower thyroxine secretion, diminished thyroid responsiveness to hormonal stimulation, and evidence of impaired thyroid gland function. These endocrine changes were accompanied by greater insulin resistance, altered triglyceride metabolism, and reduced insulin secretion in overweight animals, indicating that stress-related neuroendocrine dysfunction may extend well beyond the brain. Importantly, the findings suggest that behavioral characteristics may influence how endocrine systems age. Rather than experiencing identical biological changes over time, individuals with greater vulnerability to stress may develop more severe hormonal disturbances that contribute to age-related disease. Full press - https://aging-us.net/2026/07/01/nonhuman-primate-research-reveals-how-aging-stress-and-behavior-may-interact-to-increase-disease-risk/ DOI - https://doi.org/10.18632/aging.206388 Corresponding author - Nadezhda D. Goncharova - ndgoncharova@mail.ru (ORCID id: 0000-0002-2720-9846) Abstract video - https://www.youtube.com/watch?v=yj8zvthBiA4 To learn more about the journal, please visit https://www.Aging-US.com and connect with us on social media at: Bluesky - https://bsky.app/profile/aging-us.bsky.social ResearchGate - https://www.researchgate.net/journal/Aging-1945-4589 X - https://twitter.com/AgingJrnl Facebook - https://www.facebook.com/AgingUS/ Instagram - https://www.instagram.com/agingjrnl/ LinkedIn - https://www.linkedin.com/company/aging/ Reddit - https://www.reddit.com/user/AgingUS/ Pinterest - https://www.pinterest.com/AgingUS/ YouTube - https://www.youtube.com/@Aging-US Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM
Listen to three of the Top 10 EMEUNET Abstract Award winners as they share the research behind their award-winning abstracts, recorded live at the EULAR 2026 Congress in London. From real-world outcomes in psoriatic arthritis to AI in patient education and innovative approaches to assessing disease activity in myositis, discover the stories behind the science and the latest research shaping the future of rheumatology.
On the Flyover Conservatives Show, Peter A. Kirby joins David and Stacy Whited to expose what he calls one of the biggest scientific cover-ups in history: chemtrails, geoengineering, and the “New Manhattan Project.” As the author of Chemtrails Exposed: A New Manhattan Project, Kirby breaks down the difference between normal contrails and the long-lasting lines he says are evidence of particulate spraying, connecting his research to coal fly ash, weather modification, electromagnetic energy, Halliburton, state-level anti-geoengineering bills, and whistleblower claims. In this explosive interview, Kirby explains why he believes chemtrails are not only real, but part of a global effort to control weather, damage the natural world, and push humanity toward a synthetic future. He also shares what citizens can do now, including supporting anti-geoengineering legislation, legal efforts, and public awareness campaigns. If you've ever looked up at the sky and wondered what is really going on, this is the interview you cannot afford to ignore.To Schedule A Time To Talk To Dr. Dr. Kirk Elliott Go To ▶ https://flyovergold.comOr Call 720-605-3900 ► Receive your FREE 52 Date Night Ideas Playbook to make date night more exciting, go to www.prosperousmarriage.comTO WATCH ALL FLYOVER CONTENT: www.theflyoverapp.comFollow and Subscribe on YouTube: https://www.youtube.com/@TheFlyoverConservativesShow Peter KirbyWEBSITE: https://PeterAKirby.comX: https://x.com/PeterAKirbyBOOK: https://a.co/d/0cJ17sDt Peter A. Kirby is an independent researcher, writer, activist, and author of Chemtrails Exposed: A New Manhattan Project. He has spent years investigating chemtrails, geoengineering, weather modification, and what he describes as the hidden scientific infrastructure behind atmospheric spraying programs. Kirby is known for compiling government documents, historical weather modification research, environmental data, and whistleblower claims into one of the most comprehensive bodies of work on the subject. His research has been featured across major alternative media platforms, including a long-form interview with Tucker Carlson. Through his book, website, and Rumble show The Abstract, Kirby continues to educate the public and call for legal, political, and citizen-led action against geoengineering.
TechSurge is sponsored by Notion. From product roadmaps to investor updates, Notion is where modern teams plan, write, and ship together. Get started at http://notion.dev/techsurge.Search began as a way to find pages. AI is turning it into a way to ask, reason, decide, and act.Search has always been more than a technical problem. It is a way of organising knowledge, connecting intent with information, and increasingly, turning questions into actions. In the age of artificial intelligence, that basic function is being redefined.In this episode of TechSurge, host Sriram Vishwanath speaks with Prabhakar Raghavan, Chief Technologist at Google, about the long arc of search: from the early web and link analysis to knowledge graphs, language models, transformers, Gemini, and the unresolved question of how AI will change the way we find, trust, and use information.Prabhakar reflects on his career as a computer scientist, researcher, and technology leader, beginning with his time at IBM Research, where he worked on algorithms, optimization, databases, and early information retrieval. He explains how the explosion of unstructured data on the web created a new class of technical and economic problems. Search was not simply about indexing pages; it was about imposing structure on a chaotic information environment and building mechanisms that could connect supply, demand, relevance, authority, and trust.The conversation traces how early search evolved through link analysis and PageRank, drawing on ideas from scholarly citation analysis, graph theory, and algorithmic ranking. Prabhakar describes why authority and trust became central to search as the web grew, and why users themselves changed alongside the technology. As search engines became more capable, people moved from looking for simple webpages to asking richer, more contextual questions that required intent understanding rather than mere document retrieval.Sriram and Prabhakar then explore the transition from classical search to AI-infused products. Through examples such as Gmail Smart Reply, Smart Compose, Google Drive recommendations, and knowledge graphs, Prabhakar shows how prediction, context, and language modelling were already reshaping user experiences well before the current generative AI wave. These systems were early signals of a broader shift: computers moving from retrieving information to anticipating what users might need next.The episode also offers a technical tour of the major algorithmic milestones that led to today's AI systems, including deep learning, sequence-to-sequence models, attention mechanisms, transformers, and the compute architectures needed to train and serve large models. Prabhakar explains why attention changed the quality of language modelling, why AI systems appear increasingly conversational, and why compute remains one of the central constraints in the field.At the heart of the discussion is the central tension facing search today: if AI systems can generate answers directly, what becomes of search as we know it? Prabhakar does not frame AI as the end of search, but as its next transformation. The future of search may be less about finding a page and more about understanding intent, synthesising knowledge, reasoning through ambiguity, and helping users complete complex tasks.The conversation closes with deeper questions about AI world models, hallucination, test-time compute, diffusion models, recursive self-improvement, theorem proving, and whether AI systems can ever reason with the same grounded understanding as humans. For Prabhakar, the challenge is not only to build more powerful models, but to understand their limits, failure modes, and relationship to truth.This episode is a wide-ranging exploration of how search became one of the defining technologies of the internet age—and how artificial intelligence may now force us to rethink what it means to search at all.Sign up for our newsletter at techsurgepodcast.com for updates on upcoming TechSurge Live Summits and future episodes.Links:Prabhakar Raghavan - Google Research profile: https://research.google/people/prabhakarraghavan/?&type=googlePrabhakar Raghavan - Google blogs and writing: https://blog.google/authors/prabhakar-raghavan/References Mentioned During the DiscussionBrin and Page - The Anatomy of a Large-Scale Hypertextual Web Search Engine: https://research.google/pubs/the-anatomy-of-a-large-scale-hypertextual-web-search-engine/Page, Brin, Motwani and Winograd - The PageRank Citation Ranking: https://ilpubs.stanford.edu:8090/422/1/1999-66.pdfJon Kleinberg - Authoritative Sources in a Hyperlinked Environment: https://www.cs.cornell.edu/info/people/kleinber/auth.pdfManning, Raghavan and Schutze - Introduction to Information Retrieval: https://nlp.stanford.edu/IR-book/ Google - Introducing the Knowledge Graph: things, not strings: https://blog.google/products-and-platforms/products/search/introducing-knowledge-graph-things-not/Google Help - How Google's Knowledge Graph works: https://support.google.com/knowledgepanel/answer/9787176Further ReadingKrizhevsky, Sutskever and Hinton - ImageNet Classification with Deep Convolutional Neural Networks: https://proceedings.neurips.cc/paper/2012/hash/c399862d3b9d6b76c8436e924a68c45b-Abstract.htmlVaswani et al. - Attention Is All You Need: https://papers.neurips.cc/paper/7181-attention-is-all-you-needDevlin et al. - BERT: Pre-training of Deep Bidirectional Transformers for Language Understanding: https://aclanthology.org/N19-1423/Chen et al. - Gmail Smart Compose: Real-Time Assisted Writing: https://arxiv.org/abs/1906.00080Kannan et al. - Smart Reply: Automated Response Suggestion for Email: https://arxiv.org/abs/1606.04870Hoffmann et al. - Training Compute-Optimal Large Language Models: https://arxiv.org/abs/2203.15556 Tay et al. - Scale Efficiently: Insights from Pre-training and Fine-tuning Transformers:
Multiple myeloma is the second most common blood cancer in the United States and has long been considered a difficult disease to treat. For decades, treatment options were limited, and survival remained poor. However, the therapeutic landscape has changed dramatically over the past several decades with the introduction of stem cell transplantation, targeted drugs, immunotherapies, and more recently, CAR T-cell therapy and bispecific antibodies. A research paper titled “Targeted therapeutics and U.S. population-level mortality trends in multiple myeloma: A SEER-based analysis from 1975 to 2023” was published in Volume 17 of Oncotarget. In this study, the researchers examined how these major treatment advances have coincided with changes in multiple myeloma mortality across the United States over nearly five decades. The study was led by first and corresponding author Navkirat Kahlon from the Mass General Cancer Center at Wentworth-Douglass Hospital in Dover, New Hampshire. Full blog - https://www.oncotarget.org/2026/06/29/targeted-therapies-have-coincided-with-a-dramatic-decline-in-multiple-myeloma-mortality-in-the-united-states/ Paper DOI - https://doi.org/10.18632/oncotarget.28877 Correspondence to - Navkirat Kahlon - nkahlon@mgb.org; (ORCID: https://orcid.org/0000-0003-1115-2029) Abstract video - https://www.youtube.com/watch?v=-TNWkG9FyUo Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28877 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, multiple myeloma, epidemiologic trends, mortality reduction, therapeutic advancements, SEER database To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us on social media: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM
Performance and Works used with permission from the artist and venue. Aaron Lebos is a 25-year veteran of the Miami jazz scene. He's a guitarist and composer who tours internationally with Nicol Henry and the Nu Deco Ensemble among others. In his quest to grow and expand musically he recruited three younger South Florida musicians to form Abstract Citizen. Appearing here courtesy of a grant from Jazz Roads, and featuring Aaron Lebos on Guitar, Marty Quinn on Bass, Vania Junco on Vocals and Lucas Apostoleris on Drums, and from a May 23rd, 2025 performance, it's Abstract Citizen…Live at the Bop Stop.
IP Fridays - your intellectual property podcast about trademarks, patents, designs and much more
My co-host Ken Suzan and I are welcoming you the episode 176 of the IP Fridays Podcast. Today's interview guest is returning guest Franklin Graves, who is a senior counsel at Linkedin and teaching IP law at Emerson College. With my co-host Ken Suzan he is discussing how the law for creators has dramatically changed in the past years. Franklin Graves is expressing his personal views and not the views of Linkedin or Microsoft. He is talking about the paper “Upload Complete” before he joined Linkedin. Bio: https://www.linkedin.com/in/franklingraves/ Paper: https://papers.ssrn.com/sol3/papers.cfm?abstract_id=5271442 Website: https://creatoreconomylaw.com/ But before we jump into this interview, I have news for you! Richard Meade, a judge on the UK High Court and one of the most prominent figures in European patent law, was appointed Lord Justice of Appeal at the British Court of Appeal on June 12, 2026. Meade played a key role in numerous landmark British patent decisions, particularly in the area of standard-essential patents (SEPs) and FRAND licenses. In Insulet Corp. v. EOFlow Co., No. 2025-1807, the U.S. Court of Appeals for the Federal Circuit completely overturned the original $452 million judgment (which had already been reduced by the District Court to $59.4 million) in favor of Insulet. In its decision of June 2, 2026, in the case of Fujifilm v. Kodak, the UPC Board of Appeal provided comprehensive clarifications regarding so-called “long-arm jurisdiction”—that is, the question of whether the UPC can also rule on national patent claims outside the UPC territory (such as in the United Kingdom). In 14 guiding principles, the judges established specific procedural rules for various categories of cases. There is no automatic UPC jurisdiction over national patent claims outside the UPC territory. The Munich Regional Court has issued an arrest warrant against the managing director of Polytech Health & Aesthetics GmbH because he is alleged to have continued to exploit the Brazilian company Silimed's patent for breast implants despite a preliminary injunction. A number of IT and automotive industry associations—which are among the most frequent users of Inter Partes Reviews (IPR) at the U.S. Patent and Trademark Office—have filed an amicus brief with the Supreme Court, urging the Court to grant Google's certiorari petition. An attorney for a Las Vegas performer has asked a California federal judge to temporarily prohibit Taylor Swift from using “The Life of a Showgirl” as a trademark while the trademark lawsuit is pending. Swift's attorney called the lawsuit baseless. And now let's hear Ken discuss creator law with Franklin! AI, Platform Law, and the Creator Economy: What Businesses Need to Know Now Franklin Graves has spent his entire career watching digital content move through systems that most people never see. He started in marketing at a major music label right out of law school, then represented individual creators on YouTube in a pro bono capacity, then moved to the platform side at Eventbrite, and today works as Senior Product Counsel at LinkedIn, where he focuses on AI, data, and the regulatory questions that come with both. His recently published law review article, Upload Complete: An Introduction to Creator Economy Law, is the first academic paper to address the creator economy as a distinct legal field. In a recent episode of the IP Fridays podcast, he spoke with host Kenneth Suzan about responsible AI development, platform regulation, and what it actually means to own your audience in a world where the rules keep changing overnight. From Content Creator to Platform Lawyer The through-line in Graves’ career is a genuine understanding of how content moves from an idea in someone’s head to an audience on a screen. That experience, he argues, is precisely what in-house counsel needs right now. Lawyers working on AI and product development cannot afford to sit at a distance from the technology they are advising on. They need to use the tools, experience them as a creator or end user would, and understand the nuances of how a product actually operates before it reaches the public. Understanding the product first is the precondition for everything else. That philosophy translates directly into how he approaches responsible AI implementation. The landscape of AI standards is crowded: NIST frameworks, the EU AI Act, sector-specific guidance, and a growing body of industry-adopted best practices. The challenge for in-house counsel is not knowing that these standards exist. It is making them actionable for the engineering and product teams they support. Abstract principles need to become concrete controls and workflows. Graves offers one practical shortcut: most companies already have open source software review processes that involve the right stakeholders, the right sign-off levels, and the right security checks. Layering the specifics of generative AI or large language models onto those existing processes is far more efficient than building something new from scratch. A Fragmented Regulatory World The geopolitical dimension of AI regulation is something Graves thinks about constantly in his role at LinkedIn. The EU AI Act, shifting US executive orders, and country-specific approaches to data privacy have created a regulatory environment that can change the rules of the game without warning. His analogy is instructive: creators have long understood what it means to build a community on a platform they do not own. An algorithm change, a policy update, or a government ban can wipe out years of audience-building overnight. Businesses deploying AI tools globally now face a structurally similar problem. The response, for creators and for platforms alike, is to build resilience rather than rely on stability that may not last. TikTok is the clearest recent example. When the platform faced the prospect of being shut down in the United States on national security grounds, it triggered a broader conversation about platform dependence that had been building for years. Creators who had invested their entire business in one platform suddenly confronted the possibility that their audience could simply disappear. The lesson is not that platforms are bad. It is that concentration of any kind, whether it is your audience, your data pipeline, or your regulatory compliance strategy, creates fragility. What Is a Creator, Legally Speaking? One of the central contributions of Graves’ law review article is definitional. The terminology matters more than it might seem. When courts and regulators talk about creators without a shared understanding of what that word means, the resulting legal analysis tends to miss the mark. Graves draws a distinction between users who post content, creators who post with the intent to build an audience and eventually monetize it, and influencers, a subset of creators who are actively running a small business through their content. The difference is intent. A parent posting family photos on Facebook is a user. Someone building a subscription community around their professional expertise is running a business, and the legal framework that applies to them should reflect that. That distinction matters practically when it comes to liability. As more creators build their own platforms, whether through custom membership sites, open source tools like Ghost, or federated social networks, they take on obligations that previously fell to large platforms: content moderation policies, privacy notices, terms of service, and compliance with data regulations across multiple jurisdictions. A creator in Tennessee running a membership platform with subscribers in Germany is operating a global business, whether they think of themselves that way or not. Protecting Children Online: A Question Without a Clean Answer The tension between age verification and privacy is one of the more difficult problems in platform law right now. Australia, several European countries, and a growing number of US states have introduced or passed minimum age requirements for social media accounts. The technical challenge is real: verifying age online requires collecting identifying information, and collecting identifying information creates privacy risk, particularly for the young people the laws are designed to protect. Who should bear the responsibility for that verification is also unresolved. Is it the platform? The app store? The mobile operating system? Graves does not pretend there is a clean answer, but he points to the mobile layer as an underexplored option. The Apple App Store and Google Play Store already have significant leverage over which apps reach users on their devices. Whether that leverage should extend to age verification is a question that deserves more attention than it currently receives. The Right of Publicity in the Age of AI Voice cloning, digital replicas, and AI-generated synthetic media have pushed the right of publicity into territory that traditional IP law was not designed to cover. Trademark law, copyright law, and existing publicity rights each capture part of the problem but none of them covers it completely. The result, as Graves describes it, is a period of experimentation: lawyers filing trademarks on vocal sounds and phrases, states updating their publicity statutes to explicitly mention artificial intelligence, and entertainment unions negotiating over who controls a performance and any AI-generated iterations of it. Tennessee’s Elvis Act is a concrete example of the legislative response: the state updated its right of publicity law to include voice and to reference AI directly. Similar efforts are underway elsewhere. The underlying challenge is calibrating protection so that it gives creators and performers meaningful control over their likeness and voice without foreclosing the development of generative AI systems that depend on broad rights to process and learn from content. Somewhere between those two interests, a workable legal framework needs to emerge. The brand deal context may be where the issue becomes most immediately practical. When a brand partners with an influencer and the campaign involves generative AI in any form, the contract needs to address control explicitly. Who has final approval over how the influencer’s likeness or voice is used in AI-generated deliverables? What happens to those assets after the campaign ends? These are not hypothetical questions. They are contract drafting problems that any brand counsel or creator attorney should be addressing today. What Comes Next Graves is cautious about predictions, but his sense of direction is clear. The regulatory environment will continue to fragment before it converges. The right of publicity will be updated, imperfectly, in more jurisdictions. Creators will continue to move toward owning more of their infrastructure. And the lawyers who do this work best will be the ones who understand the technology well enough to translate it into practical, defensible decisions for the people they advise. Full Transcript: Ken Suzan: Thank you, Rolf. Our returning guest today is Franklin Graves. Franklin is the founder and editor of Creator Economy Law, a website and newsletter that educates creator economy professionals on the intersection of law and policy with the world of creators, brands, and platforms. Franklin also published the first law review article focused on the creator economy, Upload Complete, an introduction to creator economy law. He regularly appears across news and media outlets as a commentator and contributor with a focus on educating creators and raising awareness of all legal aspects of the creator economy. Franklin is based in Nashville, Tennessee. Ken Suzan: Franklin was invited to participate as one of the creators and creator economy professionals in the first ever White House creator economy conference. Franklin works full time as a product counsel at LinkedIn Corporation. As a member of the product and data team, he focuses on emerging issues in AI and data. Franklin previously held roles on the technology law group at HCA Healthcare, the commercial legal team at Eventbrite, and the business and legal affairs team at Naxos Music Group. Welcome back Franklin to the IP Fridays podcast. Franklin Graves: Thank you so much for having me. It is exciting to be back and reflecting over the last decade since I last joined and also the paper that I wrote that dives into this in more detail. So I really appreciate it. And yes, full disclosure, I currently work for LinkedIn, which is a subsidiary of Microsoft. I’m here in my personal capacity to talk about this, the paper I wrote before joining LinkedIn and all of that. So thank you so much for having me back. Ken Suzan: Excellent. So Franklin, since your last appearance on IP Fridays in 2017, your career has evolved significantly. You are now senior product counsel at LinkedIn focusing on AI and data. How has working inside a major tech platform changed your perspective on the legal frameworks governing digital content compared to when you were viewing it purely from the creator side? Franklin Graves: I appreciate that question because when I wrote the article, I did not work for LinkedIn. And I had been coming from a history in my career where I, right out of law school, worked for a record label like we talked about almost 10 years ago. And I was on the content creation side. I’ve represented a major distributor of classical music digitally at the time. And that was my first exposure to understanding how content was taken from the initial inception stage from creators and routed through all the various digital platforms that were at the time still evolving and even arguably still today continue to evolve. The early days of YouTube Music launching and then Apple Music launching, and then going through all the phases of high-res audio and everything that came after that. So that was an interesting perspective to start my career with. And then I went to Eventbrite, which is a ticketing platform, but was also focused on elevating event creators. They kind of took on that moniker of “Hey, we are event creators that we support.” And that was arguably my first exposure to the platform side, the tech platform side of it, because Eventbrite is a platform. And so then I evolved from there in my personal capacity, in a pro bono capacity representing individual creators across the YouTube space. And that’s what we talked about a little bit back when I first came on the podcast. Franklin Graves: Over the last decade, it’s been a chance to grow my own understanding of the creator economy. The terminology “creator economy” came around. And then now on the other side of it, having written the article and all that, and now being fully in-house at LinkedIn, I truly am experiencing a social media platform. LinkedIn is of course arguably way more than just the platform itself. There are so many different avenues to it, but it is a chance for me to understand what it is like working for a company that is operating the platform that people are distributing content on. There’s a user journey to content and all of that. So it’s definitely enhanced and given me a different perspective from a major tech platform side. And part of my role at LinkedIn is really heavily focused on understanding regulation and how that from an AI and data perspective impacts the company. And so I’ve been really leveling up my game over the last year and a half that I’ve been here, understanding mostly EU regulations, but also US regulations that are still in their infancy when it comes to AI. But really when it comes to privacy and data, those are pretty well established across the board. It’s been kind of a combination of what I learned at Eventbrite, because I went to Eventbrite when GDPR was going into effect. And so that was an eyes-wide-open moment of getting in the weeds with negotiating data processing agreements, understanding data transfers and cross-border data transfers and the like. So it’s been kind of an evolution as the laws and regulations have evolved. So has my career, so has my own understanding, so have the platforms’ responses to those laws and regulations. And I’m sure that probably resonates with a lot of your listeners who have also been growing their practice and their understanding as the laws and regulations in this realm have been evolving too. Ken Suzan: Yes, indeed. Now let’s switch gears and talk about AI. You advise on AI and data daily. As platforms integrate generative AI tools into their tech stacks, what are the most critical best practices in-house counsel should be adopting right now to embed responsible AI principles into product development? Franklin Graves: So as an attorney, one of my key roles is to understand the technology. Even representing creators and working for creator platforms, that’s something I’m constantly trying to do: put myself in the shoes of being a creator. And I think I talked about this last time I was on, but I come from a background where I was working for a major label doing marketing, video editing, social media work. And I was creating content. I understood the whole life cycle from the inception point of an idea to execution and then to the final delivery and distribution of that content to an audience within a major music label. And so part of that is the same thing that I think attorneys, especially in-house, should be doing: using the tools that the product and engineering teams are either developing in-house or partnering with third parties to develop, or a combination of the two. Using them, understanding them, using them as a creator would, using them as an end user or a client or customer would. And making sure that if you understand the product and understand the nuances of how it operates, and being a part of the iterations of that internally before it fully ramps, that really gives you a chance to understand: okay, we have a lot of responsible AI principles and standards and protocols that are in existence right now, whether it’s NIST, whether it’s based on the EU AI Act or anything and everything in between. It’s understanding how to apply those and bring those into a product and an engineering environment in a way that is practical and actionable for the people that you’re supporting, the stakeholders you’re supporting. So I think one of the critical best practices is, number one, understand the product or features that you’re supporting. Franklin Graves: And then understand how you as an attorney can use your expertise and understanding of responsible AI practices, whether it’s a regulatory standard or an industry-adopted standard or a hybrid of the two, to leverage those and implement those, break those down and make them into actionable controls and processes and flows that work within your existing infrastructure. That’s a lot of high-level talk, but that’s the general idea. One concrete example we talk about frequently is with open source AI. If you’re working with a product team or an engineering team that is taking an off-the-shelf open source model and bringing that in-house, a lot of times companies have pre-existing open source processes that cover the use of open source software or code. Piggyback on that. That’s the easiest quick win for attorneys: leveraging your existing open source processes to just build on top of that the AI flavor and layering. It’s not very much that you have to do, but the underlying process of the key stakeholders that need to be involved in the review, whether it’s security, whether it’s executive sign-off if it gets to that point, even export control considerations should already be part of your existing open source software process. So layering in on those existing processes the specifics of generative AI or large language models that you’re trying to bring in is a great way to put this into practice. Ken Suzan: Now looking at the geopolitical landscape that we currently have, we have the EU AI Act setting strict standards and shifting US executive orders. How should platforms and brands prepare for this fragmented regulatory environment when deploying AI tools to a global user base? Franklin Graves: It’s a great question. It’s something that is still evolving, I think is fair to say. I would equate it, as I do in the paper that I wrote, to how creators and arguably brands don’t own the platforms that they’re building their communities on. That spawned this concept of de-platforming or going into building your own platform, a decentralized platform of sorts, and owning your community. That gives you that control and takes away the level of instability that can come for creators trying to build a business on a platform they don’t own, they don’t control when certain updates happen, when algorithms change, when tools and functionalities either become available or go away completely. So it’s very similar to what we’ve been experiencing in a regulatory environment where we have geopolitical complexities, for lack of a better term, that can overnight seemingly disrupt the way in which a platform or even a multinational brand is able to connect and reach an audience or continue to leverage the user base that they’ve built. I think TikTok is a great example of that, where it became a national security concern and suddenly it was facing an executive order that required it to be effectively disabled in the US or completely owned and operated by a US entity. All the mechanics and technicalities of whether it’s actually possible and still have a global platform with a global user base is a whole different discussion. But that’s an example of very similar considerations that are now not just a discussion point at the creator level or the individual brand level, but also in a much broader context at a platform level as well. Ken Suzan: Franklin, let’s now shift gears and talk about your article. In your recently published journal article, Upload Complete, which we will have linked in our show notes, you advocate for a shift in terminology from internet creator law, a term used during our first podcast almost a decade ago, to creator economy law. Why is this distinction important and how does it change the way legal practitioners should view the ecosystem of creators, brands, and platforms? Franklin Graves: Oh yes, this is part of the reason why I wanted to write the article: to lay this foundation of understanding. Because at the time I’d written the article, the term creator economy and creator had really not appeared but for maybe once in an actual court decision. And it was kind of focused on influencers and this concept, and it was just not getting it right. And so it was also, as you mentioned, when we first spoke I was even using the term internet creators. And I think that was something that was common at the time. The “internet” portion as a qualifier has since dropped off. And now for purposes of the creator economy, the term creators refers to individuals, it can be small businesses, which is what we’ve seen from a regulatory standpoint, how these small businesses are being impacted by regulations. But essentially creators in the article I pin in the context of intent. What is the intent behind the person or the small business that is posting content, trying to build a community and form a community in a virtual environment? And then that can even spill over into real physical world environments. And so the intent is kind of what I look at. Franklin Graves: And I have a chart in the article that has a diagram showcasing the overlap of what I refer to as “users generating content.” It’s a play on the concept of user-generated content, UGC. Users generating content is that large bucket of anyone posting on a platform of some kind. And within that large bucket, that large circle, are smaller subsets. You have creators, you have brands. Those are really the two buckets you can put people into. Otherwise it’s like your grandmother or your parents posting content on Facebook or Instagram, and those are everyday users of a platform. The distinction to get into that subcategory of being a creator more so has been analyzing the intent behind the posting. Are you posting content to build an audience, to build a community, to eventually have a chance to monetize the following that you’re bringing in or sell services or something like that? Brands are posting for that reason. Creators are maybe posting for that same reason. But even within the creator category, there’s a subcategory of influencers that are trying to sell something, that are trying to build more than just an awareness of who they are, their influence. They are trying to do brand deals, partnership deals, upsells and all that, and start an actual small business aside from just the content itself that they’re creating. So that’s kind of the distinctions that I make in the paper. And that’s why it’s important to understand and lay that foundation, that anyone can post content online, but the intent, the why behind their posting that content, really does ultimately matter, especially when you’re looking at it from a court case or from a regulatory standpoint. Ken Suzan: Now, Franklin, we’re seeing unprecedented geopolitical activity around platform ownership. For example, the US legislation targeting TikTok and Brazil’s recent temporary ban of X. How do these macro-level battles impact the day-to-day livelihood of creators? And how can they legally and operationally protect themselves? Franklin Graves: So the shift that we’re seeing, and I alluded to this earlier in our conversation, is this concept of Web 3. And that term may or may not be really popular anymore, but that’s essentially what we’re looking at: a shift into a federated, decentralized operation of a platform. So instead of one owner, one company, one entity owning and operating the platform, it’s decentralized. Anyone can start up a server, and it’s interoperable, meaning anyone can plug and play and connect to that larger network. And it creates this unified social network experience. Within each operating node of that network, there can be your own decisions around content moderation, your own decisions around the hosting providers you use, where you’re operating out of, the terms and conditions that apply to that. But the flip side is that instead of creators posting and sharing in a closed environment run and controlled by a singular entity, you’re now experiencing a peer-to-peer type operation where your experience can change based on which server, which node, which user you’re engaging with. You might have content that’s acceptable in one area but not acceptable in another, and maybe it just doesn’t even show up in that other area. Franklin Graves: But from a liability standpoint, as creators start to build their own networks and communities, even outside of a concept like the fediverse, it’s even down to creators building their own communities through online courses, subscription membership-based platforms that they run on their own website. There’s open source software out there, even something called Ghost, where you have memberships. And that is a creator or a small business in the creator economy that is now taking on the obligations that would typically fall upon a platform. They need to take into consideration terms and conditions, privacy policies, legal aspects, and regulatory considerations for running a platform, especially in a global world. So it’s a lot of liability that then shifts over to those small businesses and even brands sometimes that are doing the same thing. Whether it is something as simple or complex as content moderation or all the way up to monetizing an audience, this new world where creators can spin up and run a platform all dovetails back to the concept of creators not feeling like they have control in reaching the audience and the community that they’re building on an individual platform. And so this really became more mainstream conversation with TikTok and the issues around it potentially being shut down in the US. That was kind of the mindset shift and eyes opening for many creators, especially within the influencer subset, of realizing: we need to make sure that we have a way to reach the audience we’ve built if the individual platform that we’ve committed to over the last year or three years or so is no longer available. We need a way to continue that relationship outside of that one platform controlling it. Ken Suzan: Franklin, we have a few minutes left and a number of topics. So I’m going to switch gears and talk about a few issues. First, a major emerging topic in your paper is the evolution of protecting kids online. With state-level age-gating laws like the CAADCA and the recent FTC updates to COPPA, how should platforms navigate the significant tension between strict age verification mandates and the privacy and First Amendment rights of their users? Franklin Graves: Man, that is a whole discussion to unravel. It is a consideration that we’re seeing happen again, going back to the geopolitical nature of everything. Countries like Australia and certain countries in Europe and now even individual states in the US are trying to look at ways, and some of them have already put into place minimum age requirements before you can even sign up for an account with a social media platform. One of the things I’d just highlight quickly here is that one of the tensions is around how you verify someone’s age online and still maintain the ability to be at least pseudonymous. How do you still have a level of privacy, autonomy, and protection when it comes to having to provide something like a driver’s license or have parental consent tied and connected to an account managed by a parent in a situation where maybe it’s not appropriate or not beneficial to the child in that manner? But then maybe there are counterbalancing factors that outweigh that. All of that comes down to the technicalities of how it’s actually implemented and maintaining the sense of openness and freedom that we’ve had on the internet to date. And then the other element there is, since a lot of the internet that we think of today is more so through mobile applications, is it something that the mobile operating system providers and app store providers should be thinking about? So whether that’s the Google Play Store or the Apple App Store, where does that initial age verification need to fall? Is it at the platform level? Is it the app store or mobile device management level or something else? Yeah, there’s a lot to discuss there. And a lot of the issues we’re seeing with how the internet is changing in terms of being able to browse a website without disclosing personal information that might not have been required before is largely stemming from a focus on protecting children online. Ken Suzan: It sounds like, Franklin, we could have another episode covering lots of issues connected with that one topic alone. Franklin Graves: I would absolutely agree with that. There’s a lot going on there. And again, it’s different across the world. And so I know you all have a global listener base. And so there’s a lot of nuances to that whole discussion too, that are worth exploring. Ken Suzan: Last question for today’s episode is regarding the right of publicity. With the explosion of AI-generated synthetic media, digital replicas, and voice cloning, the right of publicity is taking center stage. What are the biggest legal risks for brands partnering with influencers right now? And how can creators protect their most valuable asset, their likeness? Franklin Graves: That’s a great question. I think we’re seeing kind of a throwing-spaghetti-against-the-wall-to-see-what-sticks approach right now by a lot of different parties, whether it’s trademark attorneys, whether it’s general entertainment attorneys or whoever. For example, we’ve seen Taylor Swift filing trademarks to protect certain sounds of her voice and phrasing that she uses. It’s a difficult area because in the realm of generative AI with deep fakes and virtual avatars, that is where it gets tricky, because traditional IP laws are just not able to fully cover that spectrum. It’s a piecemeal approach, but even then it doesn’t fully cover it. So for example, I’m based in Tennessee and a couple of years ago we had the Elvis Act that updated our right of publicity law to add voice and to explicitly reference artificial intelligence. And so that’s the kind of effort we’re probably going to continue to see: efforts to develop some framework around protecting what is essentially a privacy right, in a manner that doesn’t restrict generative AI systems from continuing to develop and operate the way they’re operating now, while layering in those protections so that in the US at least a First Amendment right doesn’t necessarily get squashed, and those traditional well-recognized efforts to not overregulate a technology in its early stages are respected. Franklin Graves: And so I think a lot of what we’re seeing is just a need to update laws. The SAG-AFTRA debate and the strikes that happened around maintaining control of your performance and any iterations of that, or building upon that by a media company that might come later, it’s all on the table right now and still being discussed, still being worked out. I think in the short run, a lot of times if it’s in a brand deal, the key question is: if you are using generative AI to enhance in some way the final deliverable for the campaign, who has control over that? Who has final say and sign-off on how that likeness or that digital replica or that person’s voice is represented? And even outside of the brand space, we’ve seen actors like James Earl Jones signing over certain aspects like their voice and allowing it to continue to be used in these manners powered by generative AI as Darth Vader. And I think I saw something that Boy George was even starting up an AI company that allows musicians, the original recording artist, to rerecord new versions of their masters so that they don’t miss out on that revenue. It’s powered by generative AI, by taking their voice now, which is significantly different than it was back in the 80s, and using generative AI to make it sound closer to the original, but all based on their current performance. So I think it’s still an evolving area. And what’s interesting too is on the platform side, we’re seeing the early stages of platforms like Google starting to acknowledge and rely on the license grant contained in their terms of service for YouTube, which grants them broad rights to use the content to run their platform. So all that to be said, it’s still early stages. I’m very interested to see where we go from here in the future, especially from a global perspective as well. Ken Suzan: Franklin, I could spend hours talking to you about this. You’re such a knowledgeable person on these topics. Maybe in a few years, will we connect again and talk further on AI and all the things that are yet to be developed? Franklin Graves: Thank you. Yeah, it doesn’t have to be another decade. Maybe we can cut it to half a decade, given the pace at which technology is going now. Ken Suzan: Sounds good, Franklin. Thanks again for being on the IP Fridays podcast.
Don't be scared.Pure abstract games may have no theme, no dice rolling or luck and have simple rules with deep complexity.But they are fun! Seriously!!!Especially the three simple, pure abstract games that the gamer bros share with you!
Karyn Gabriel is a San Francisco Bay Area artist with a BFA from the University of Michigan and post-baccalaureate studies in ceramics at Oregon College of Art and Craft. Grounded in pattern as a visual language, Karyn's sculptures are inspired by structural references from architecture to textile construction. Pared down, elemental forms expose a slightly brutal beauty while emphasizing the interplay between surface and structure. https://ThePottersCast.com/1239
I used to think something was wrong with me. I'd sit there knowing a task mattered — knowing it mattered yesterday, last week, last month — and still couldn't get myself to move on it. For years I asked myself the wrong question: why isn't this getting done? The better question, it turns out, is what does my brain actually need to get started? That question changed everything, and it's where SPARK came from.Story. I'm a story person. I don't care that a bird exists — I care about the three hours I spent finding it. When I'm stuck on a task, I ask what's interesting about it, not what needs to get done. Curiosity creates momentum that obligation never will.Purpose. Abstract tasks mean nothing until there's a real person on the other side of them. Whether it's an IT ticket or a podcast episode that isn't coming together, I think about who actually needs this and why — and the task shifts even though the work doesn't.Adventure. Not everything can be an adventure (folding laundry is still folding laundry), but a lot of tasks can become small experiments instead of obligations. Possibility is motivating in a way duty never is.Reality. This one needs care, because it's easy to slide from reality into fear. Fear says you'll end up broken and miss out on life. Reality says every choice is a small vote for the future you're building. I'd rather feed the tiger that's still hiking at 80 than the one that isn't.Kickstart. Some days none of the above works. On those days, the only question that matters is: what's the smallest next possible step? Mow the front yard, not the whole lawn. Put on your shoes, not your whole workout. Starting is the hard part — once you start, momentum tends to take over.You don't need all five letters every time. Pick whichever one fits the moment, and let it do its job. Most of us aren't waking up already disciplined and on fire — and that's not a flaw, that's just being human.If you've been stuck on something, I'd love to know which letter of SPARK actually got you moving. Email me at jill@startwithsmallsteps.com or leave a comment — and until next time, keep taking those small steps.Jill's Linkshttp://jillfromthenorthwoods.comhttps://www.youtube.com/@startwithsmallstepshttps://www.buymeacoffee.com/startwithsmallstepshttps://twitter.com/schmernEmail the podcast at jill@startwithsmallsteps.comBy choosing to watch this video or listen to this podcast, you acknowledge that you are doing so of your own free will. The content shared here reflects personal experiences and opinions and is intended for informational and inspirational purposes only. I am not a licensed therapist, life coach, or mental health professional. Any habits, strategies, or suggestions offered should not be considered a substitute for professional medical, psychological, or counseling advice. Results vary — small steps look different for everyone. You are solely responsible for any decisions or actions you take based on this content.
Are you struggling to capture the attention of Chief Information Security Officers (CISOs) in a saturated cybersecurity market? Join us in this enlightening episode of The Cyber Go-To-Market Talk podcast for cybersecurity sales and marketing teams, where we unpack the secrets to effective cyber security sales strategies that can elevate your approach and drive revenue growth. Host Andrew Monaghan sits down with Chris Camacho, co-founder and COO of Abstract Security, who brings a wealth of experience from his previous roles as a buyer at financial services companies. Chris shares invaluable insights into the shifting dynamics of selling cybersecurity solutions, particularly to Fortune 500 companies. He emphasizes the critical need for cyber sales teams to either reduce current spending or replace existing vendors to gain traction, making a strong first impression that resonates with decision-makers. This episode dives deep into Chris's unique journey from being a buyer of cybersecurity products to becoming a builder and seller, offering listeners a rare perspective on what works and what doesn't in the realm of cyber security sales. With around 3,900 vendors vying for attention in the cybersecurity space, standing out is no easy feat. Chris discusses the challenges of differentiation and the evolving role of AI in both sales and product development, providing actionable insights that can help your team navigate these complexities. Building and maintaining relationships is key in the cybersecurity landscape, and Chris stresses the importance of leveraging networks effectively to understand clients' specific needs. By creating tailored solutions that demonstrate clear ROI, sales teams can not only meet but exceed client expectations. Listeners will walk away with practical takeaways on sales onboarding, sales coaching, and metrics that matter in insurance, all aimed at accelerating growth in a rapidly changing environment. This episode is packed with cybersecurity marketing insights and go to market strategies for anyone involved in cyber security sales. Whether you're part of a startup or an established company, the lessons shared here will empower you to grow sales and enhance team management capabilities. Tune in to The Cyber Go-To-Market Talk podcast for cybersecurity sales and marketing teams and discover how to navigate team challenges while building trust and scaling sales teams effectively. Don't miss out on this opportunity to get better at marketing and drive predictable revenue growth! About the guest: Chris Camacho spent around ten years on the buy side in financial services, an early adopter of vendors like Crowdstrike and Flashpoint, before crossing over to build and sell security products. He is co-founder and COO of Abstract.Chapters:00:51 — Crossing from the buy side to the "dark side"02:55 — Why he bought CrowdStrike and Flashpoint early11:45 — A market with thousands of vendors, and the spend arms race15:33 — Three ways to fill a regional CISO event18:23 — Relationships, Ninja Jobs, and meeting his co-founder22:20 — What he interviews for (and what he doesn't)26:22 — When an AI lab lands in your category29:59 — What CISOs are telling him about AI32:22 — Reduce or replace: the way in now34:17 — AI for sellers, and his 17-year-old BDR Support the showThe Cyber Go-To-Market Talk is the show for cybersecurity sales leaders, founders, CROs, and go-to-market operators looking to improve cyber sales performance and build more predictable revenue growth. Hosted by Andrew Monaghan, founder of Unstoppable.do, covering cyber sales leadership, revenue leadership, sales onboarding, forecasting, pipeline generation, and cybersecurity go-to-market execution.Follow me on LinkedIn for regular posts about growing your cybersecurity startupWant to grow your revenue faster? Check out my cybersecurity sales consulting and trainingNeed ideas about how to grow your pipeline? Sign up for my newsletter.
Abstract ideas made definite.In this episode of Mere Mortals book reviews, I dive into Peter Thiel's 'Zero To One' and why its big-picture thinking resonates more than tactical business how‑to. I explore Thiel's blend of abstract philosophy and concrete startup stories (from PayPal to Palantir) and discuss his contrarian takes on competition, monopoly and the value of being the last mover. I unpack the optimistic vs pessimistic, determinate vs indeterminate lens Thiel uses to read cultures and markets and why these frames can guide founders to build something truly unique rather than drift into “zombie company” territory. I share what made the book engaging for me, where it might fall short if you're after nuts-and-bolts execution and who I think will get the most out of it. Ultimately, it's a concise, idea-rich read that can reorient how you think about differentiation, market definition and creating from zero to one.If you got value from the podcast please provide support back in any way you best see fit!Timeline:(00:00:00) Intro(00:00:35) Introducing Zero to One by Peter Thiel(00:04:27) Contrasting with other business classics(00:07:41) Why high‑level ideas can beat operational minutiae(00:11:03) Who is Peter Thiel? Background and ventures(00:12:52) Verdict: a solid read for entrepreneurs(00:14:00) Value for Value: how to support the show(00:15:08) What's next: upcoming book reviews Connect with Mere Mortals:Website: https://www.meremortalspodcasts.com/Discord: https://discord.gg/Xs9DjsurFqTwitter/X: https://twitter.com/meremortalspodsInstagram: https://www.instagram.com/meremortalspodcasts/TikTok: https://www.tiktok.com/@meremortalspodcastsValue 4 Value Support:Website: https://www.meremortalspodcasts.com/supportPaypal: https://www.paypal.com/paypalme/meremortalspodcast
BUFFALO, NY – June 17, 2026 – A new #research paper was #published in Volume 17 of Oncotarget on June 8, 2026, titled “DHHC3 interferes with antitumor immunity in melanoma cells.” The study was led by first author and corresponding author Chandan Sharma and corresponding author Martin E. Hemler from the Department of Cancer Immunology and Virology at the Dana-Farber Cancer Institute. Melanoma is one of the most aggressive forms of skin cancer and is highly influenced by interactions between tumor cells and the immune system. Although modern immunotherapies have transformed treatment for many patients, researchers continue to search for molecular mechanisms that enable tumors to evade immune attack and continue growing. In this study, researchers investigated DHHC3, a protein acyltransferase that regulates protein palmitoylation and helps maintain cellular redox balance. Previous studies had linked elevated DHHC3 expression to poor outcomes in several cancers, but its role in melanoma and anti-tumor immunity remained unclear. To explore this question, the team used CRISPR gene editing to eliminate DHHC3 expression in B16F10 melanoma cells. Loss of DHHC3 caused a marked increase in oxidative stress and cellular senescence, as demonstrated by elevated TXNIP expression, increased reactive oxygen species levels, and enhanced expression of senescence-associated markers. Full press release - https://www.oncotarget.net/2026/06/17/protein-linked-to-melanoma-growth-may-suppress-the-bodys-natural-anti-tumor-immune-response/ DOI - https://doi.org/10.18632/oncotarget.28880 Correspondence to - Martin E. Hemler - martin_hemler@dfci.harvard.edu, and Chandan Sharma - csharma@mgh.harvard.edu Abstract video - https://www.youtube.com/watch?v=QQhP2VhzKSE Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28880 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, oxidative stress, DHHC3, anti-cancer immunity, palmitoylation, melanoma To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM
Video: https://youtu.be/rXBfeOrwE3c Abstract of Systematic Theology by James Petigru Boyce Session 3 – chapters 6-16 Subject: Theology Proper (The Trinity) Wednesday Logos – 6-17-26 Liberty Church
What happens when machinima stops telling a story… and instead pulls you inside a fractured mind?In this episode of And Now For Something Completely Machinima, hosts Phil Rice, Tracy Harwood, and Damien Valentine dive deep into “Dysfunction” by Iono Allen—a powerful, unsettling machinima film created in Second Life.This isn't your typical machinima. There's no clear beginning, middle, or end—just a visceral, abstract experience of psychological breakdown, sensory overload, and emotional fragmentation.Is it about mental health? Substance abuse? Political disillusionment? Or something even darker?
Video: https://youtu.be/rXBfeOrwE3c Abstract of Systematic Theology by James Petigru Boyce Session 2 – chapters 2, 4, 5 Subject: Theology Proper (classical arguments for God, attributes of God) Wednesday Logos – 6-10-26 Liberty Church
What is Reliability? Abstract What is the definition of reliability? Outside of the field of reliability, who defines it or what a failure is? Join Mojan and Fred as they explore how reliability is perceived across the product development ecosystem—from customers to suppliers to design engineers—and why the classic “but it met the spec!” defense […]
In a live X Spaces discussion hosted by CancerNetwork® in collaboration with the American Society for Transplantation and Cellular Therapy (ASTCT), Marc J. Braunstein, MD, PhD, and Sofia Zahid, MD, highlighted noteworthy presentations and abstracts in hematologic oncology at the 2026 American Society of Clinical Oncology (ASCO) Annual Meeting. Together, they discussed the data that may shake up clinical practice across different multiple myeloma, leukemia, and lymphoma populations.Braunstein is an associate professor in the Department of Medicine and course co-director of the Hematology/Oncology System at NYU Grossman Long Island School of Medicine, as well as the fellowship program director of Hematology/Oncology at NYU Langone Health. Zahid is a first-year fellow at NYU Grossman Long Island School of Medicine.The discussion focused on the following abstracts:· Abstract 7512o Combining belantamab mafodotin-blmf (Blenrep) with daratumumab (Darzalex), lenalidomide (Revlimid), and dexamethasone produced rapid activity among patients with transplant-ineligible newly diagnosed multiple myeloma in the phase 1/2 BelaDRd study (EUCT-2024-515634-32).o The progression-free survival (PFS) benefits observed in the trial support further evaluation of the quadruplet in a phase 3 study compared with other novel combination regimens in NDMM.· Abstract 6505o Revumenib (Revuforj) maintenance therapy after allogeneic stem cell transplantation showed feasibility in a heavily pretreated cohort of patients with acute myeloid leukemia (AML).o Outcomes appeared favorable vs historical cohorts, supporting prospective assessment of maintenance menin inhibition among those with AML.· Abstract 1503o In a retrospective analysis of electronic medical records for 293 patients who received CAR T-cell therapy for lymphoma (n = 175), multiple myeloma (n = 106), or B-cell acute lymphoblastic leukemia (n = 12), outpatient monitoring was associated with significantly fewer hospital days without increased emergency department visits or 30-day mortality.o These findings show the potential for lower healthcare utilization for patients who receive CAR T-cell therapy in the outpatient setting.· Abstract LBA7000o Adding tafasitamab (Monjuvi) and lenalidomide to rituximab (Rituxan), cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) significantly improved PFS vs R-CHOP alone among those with newly diagnosed diffuse large B-cell lymphoma (DLBCL) in the phase 3 frontMIND trial (NCT04824092).o The data may support tafasitamab plus lenalidomide and R-CHOP as a potential new standard of care in the frontline treatment of patients with cell-of-origin subtypes of high-risk DLBCL.References Terpos E, Ntanasis-Stathopoulos I, Gavriatopoulou M, et al. Belantamab mafodotin with daratumumab, lenalidomide, and dexamethasone in transplant-ineligible, newly diagnosed multiple myeloma patients: phase 1/2 BelaDRd study. J Clin Oncol. 2026;44(suppl 16):7512. doi:10.1200/JCO.2026.44.16_suppl.7512 Goulart H, Okeleji O, DiNardo CD, et al. Revumenib as maintenance for AML following allogeneic stem cell transplantation. J Clin Oncol. 2026;44(suppl 16):6505. doi:10.1200/JCO.2026.44.16_suppl.6505 Bowen SG, Abdallah N, Pritchett JC, et al. Impact of outpatient CAR T-cell therapy administration on healthcare utilization in patients with hematologic malignancies. J Clin Oncol. 2026;44(suppl 16):1503. doi:10.1200/JCO.2026.44.16_suppl.1503 Lenz, G, Trněný M, Burke JM, et al. frontMIND: phase 3 study of tafasitamab (Tafa) plus lenalidomide (Len) and R-CHOP for patients (pts) with newly diagnosed diffuse large B-cell lymphoma (DLBCL). J Clin Oncol. 2026;44(suppl 17):LBA7000. doi:10.1200/JCO.2026.44.17_suppl.LBA7000
Olga Goriunova is a cultural theorist who works at the intersection of technology, media, philosophy, and aesthetics. Born in the Soviet Union, she is now based in the UK. Her research is transdisciplinary and engages questions of subjectivation, art and computing across different scales and modes of operation.In this interview, we talk about her latest book, Ideal Subjects: Abstract People of AI. In it, she explores how data and artificial intelligence abstract people into new genres of “subjects,” mapping the horizon of individual and societal possibility.The idea of “ideal subjects” can be useful for designers and user researchers, especially when trying to understand—and question—the way our online data is produced, relates back to us and models our future.She is helping us to question: - What kind of "subject" is created through data? - How does data based representation attempt to match a human being? - How come that these data-based abstractions are able to engage our desire and thus direct our becoming in relation to their modelled prescriptions? This episode is part of several lists: Investigación en diseño, Reino Unido y diseño, Rusia y diseño, D&D in English, Filosofía y diseño, Arte y diseño social, and AI en UX. While many of the list titles are in Spanish, the content itself is trilingual. Some episodes are in English, others in Spanish or Portuguese. The list D&D in English brings together all the English-language episodes, and it now includes nearly 50 interviews.
Abstract: Members of the 1834 Zion's Camp expedition inspected a large mound along the Illinois River where a skeleton was uncovered and Joseph Smith had a revelatory experience identifying the individual as Zelph. Recent archeological excavations place the revelation in a chronological and ancient cultural context that now allows additional verification and interpretation of this revelatory event. In addition, with this new information, it is possible to determine whether the individual and location can be interpreted as being a part of the Book of Mormon culture and geography. The post A Scientific Evaluation of the Zelph Revelation first appeared on The Interpreter Foundation.
Cancer is increasingly recognized as a major global health challenge, yet for people living through war, displacement, and humanitarian crises, access to even basic oncology services can be difficult or impossible. While emergency responses typically focus on trauma care, infectious diseases, and immediate survival needs, cancer care remains largely absent from many humanitarian health programs. A review paper on this topic was published in Volume 17 of Oncotarget titled “Cancer without borders: Policy frameworks for oncology care in humanitarian and conflict settings.” The study was led by first and corresponding author Pragnesh Parmar, with Gunvanti Rathod as co-author, both from AIIMS Bibinagar, Telangana, India. Full blog - https://www.oncotarget.org/2026/06/03/cancer-care-often-overlooked-in-humanitarian-crises/ Paper DOI - https://doi.org/10.18632/oncotarget.28856 Correspondence to - Pragnesh Parmar - drprag@gmail.com; (ORCID: orcid.org/0000-0002-8402-8435) Abstract video - https://www.youtube.com/watch?v=zXlhIBZyJ6Q Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28856 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, cancer care, humanitarian crisis, tele-oncology, global health policy, oncology triage To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us on social media: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM
Chapters 1, & 3 – Abstract of Systematic Theology by James Petigru Boyce Liberty Church
BUFFALO, NY — June 3, 2026 — A new #research paper was #published in Volume 18 of Aging-US on May 15, 2026, titled “Extracellular vesicles released by senescent myoblasts affect recipient cells via miRNA-target interactions.” The study was led by first author Michael Kamal from the Department of Kinesiology at McMaster University and corresponding author Gianni Parise from the same university. As people age, skeletal muscle gradually loses strength, size, and regenerative capacity. Scientists have increasingly linked these changes to cellular senescence—a state in which damaged cells permanently stop dividing but remain metabolically active. These senescent cells release a complex mixture of signaling molecules known as the senescence-associated secretory phenotype (SASP), which can influence neighboring cells and contribute to tissue dysfunction. In this study, the researchers investigated whether extracellular vesicles (EVs)—tiny membrane-bound particles released by cells—play a role in this process. Specifically, they examined EVs released by senescent muscle precursor cells, known as myoblasts, and analyzed the microRNAs (miRNAs) carried within these vesicles. The team found that senescent myoblasts released factors that impaired normal muscle cell development. When healthy muscle cells were exposed to signals from senescent cells, the resulting muscle fibers became significantly smaller and displayed increased expression of genes associated with cellular stress and senescence. Further analysis revealed that EVs released by senescent myoblasts carried a distinct set of miRNAs. The researchers identified 22 significantly altered miRNAs, including several previously linked to cellular senescence, such as miR-34a, miR-34b, miR-34c, and miR-22. The study also identified miR-301a-3p as a potentially novel senescence-associated miRNA. Full press release - https://aging-us.net/2026/06/03/senescent-muscle-cells-send-molecular-messages-that-may-contribute-to-age-related-muscle-decline/ DOI - https://doi.org/10.18632/aging.206379 Corresponding author - Gianni Parise - pariseg@mcmaster.ca Abstract video - https://www.youtube.com/watch?v=HKBbraYg8ew Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206379 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, cellular senescence, extracellular vesicles, myoblasts, miRNA, multi-omics To learn more about the journal, please visit https://www.Aging-US.com and connect with us on social media at: Bluesky - https://bsky.app/profile/aging-us.bsky.social ResearchGate - https://www.researchgate.net/journal/Aging-1945-4589 X - https://twitter.com/AgingJrnl Facebook - https://www.facebook.com/AgingUS/ Instagram - https://www.instagram.com/agingjrnl/ LinkedIn - https://www.linkedin.com/company/aging/ Reddit - https://www.reddit.com/user/AgingUS/ Pinterest - https://www.pinterest.com/AgingUS/ YouTube - https://www.youtube.com/@Aging-US Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM
Most global businesses enter Asia with a playbook built elsewhere. The pricing models, growth assumptions, labour structures, and definitions of value that worked in North America or Europe get applied to markets that operate by fundamentally different rules. The result, as Eric Stryson has observed across nearly two decades of on-the-ground leadership work in Asia, is failure - not dramatic failure, but the slow erosion of credibility that comes from never truly understanding where you are.Eric Stryson is Managing Director at The Global Institute For Tomorrow (GIFT), an independent pan-Asian think tank with offices in Hong Kong and Kuala Lumpur. He has designed and facilitated more than 60 experiential leadership programmes across fifteen countries in Asia and the Middle East, working with over 3,000 executives from organisations including HSBC, Petronas, Marriott, MasterCard, and Standard Chartered. His public sector clients include the Hong Kong SAR Government, the Dubai Government, and the Central Bank of Malaysia.In this episode, Eric argues that much of what organisations believe they know about Asia is filtered through AI systems, research, and analysis shaped by Western institutions and historical precedents. Even conventional online research surfaces insights produced predominantly by incumbent Western policy and academic bodies, reinforcing a narrow and often distorted lens. Challenging these assumptions, he contends, requires moving beyond second-hand analysis and grounding decision-making in on-the-ground observation and lived experience.From renegotiating what 'value' means to understanding why Western growth models break down in Asia's diverse political and social contexts, Eric offers a rare perspective on what it actually takes to operate credibly in a post-Western, Asia-led growth environment. Discussion Points· Why Western-filtered research and AI-generated analysis fail businesses trying to understand Asian markets· Concrete examples of Western business models and assumptions breaking down on the ground in Asia· How Asian markets define value differently - and why pricing strategies built elsewhere so often misfire· Why 'scale fast, dominate markets' growth assumptions need renegotiating in Asia's diverse contexts· What nearly 20 years of field project work in Asia reveals that research reports and case studies don't· How consumption patterns and labour structures in Asia require businesses to rethink core operating models· What 'post-Western world' means in practice for businesses operating in China, Southeast Asia, and the Middle East· How to use AI tools responsibly when the training data reflects predominantly Western institutional perspectives· Why Hong Kong businesses face an urgent reinvention moment - and what that looks like in practice· The single most important thing Western businesses should do differently before entering or scaling in Asian marketsGuest BioEric Stryson is Managing Director at The Global Institute For Tomorrow (GIFT), an independent pan-Asian think tank with offices in Hong Kong and Kuala Lumpur. He has designed and facilitated more than 60 experiential leadership programmes across fifteen countries in Asia and the Middle East, working with over 3,000 executives from C-suite to high-potential talent. His corporate clients include AIA, BASF, CITIC, DBS, FedEx, HSBC, Marriott, MasterCard, Panasonic, Petronas, Prudential, and Standard Chartered. His public sector clients include the Hong Kong SAR Government, the Dubai Government, the Central Bank of Malaysia, and various provincial and county governments in mainland China. Eric's articles have appeared in the South China Morning Post, Financial Times, China Daily, and The Straits Times, and he has been interviewed by CNBC. Links & Resources· GIFT website: www.global-inst.com· Eric Stryson profile: global-inst.com/team/eric-stryson· SCMP: Reinvention must start now if Hong Kong businesses are to survive change· FT Letter: A Bric in a de-dollarised wall or a new architecture?· Digital Transformation Documentary: Eric Stryson on technology causing problems
BUFFALO, NY – June 2, 2026 – A new #research paper was #published in Volume 17 of Oncotarget on May 20, 2026, titled “Microenvironmental CTHRC1 has a pro-tumorigenic role in colorectal cancer.” The study was led by first author Haylee Duval from the Center for Molecular Medicine at the MaineHealth Institute for Research and the Graduate School of Biomedical Science and Engineering at the University of Maine. The study's corresponding authors were Sergey Ryzhov, Volkhard Lindner, and Michaela R. Reagan, who are affiliated with the Center for Molecular Medicine at the MaineHealth Institute for Research, the Graduate School of Biomedical Science and Engineering at the University of Maine, and Tufts University School of Medicine. Colorectal cancer remains one of the leading causes of cancer-related deaths worldwide. While much research has focused on cancer cells themselves, growing evidence suggests that the tumor microenvironment—the network of surrounding stromal cells, immune cells, and extracellular components—plays a critical role in determining how tumors grow and spread. In this study, researchers investigated collagen triple helix repeat containing 1 (CTHRC1), a secreted protein previously associated with poor outcomes in several cancer types. Although CTHRC1 is frequently detected in tumor-associated stroma, its precise role within the colorectal cancer microenvironment has remained unclear. To address this question, the team used a genetically engineered mouse model lacking CTHRC1 and compared tumor development with that of normal mice after colorectal cancer cells were introduced. The results consistently showed that the absence of host-derived CTHRC1 significantly reduced tumor growth. Across three independent experimental cohorts, mice lacking CTHRC1 developed substantially smaller tumors than their normal counterparts. In addition, survival improved markedly. The median survival of mice with normal CTHRC1 expression was 28 days after tumor inoculation, compared with 69 days in CTHRC1-deficient mice. The researchers also found evidence that CTHRC1 influences anti-tumor immunity. Mice lacking CTHRC1 had higher percentages of CD3-positive T cells in both tumors and spleens, suggesting a more active immune response against cancer. At the same time, they exhibited reduced levels of certain myeloid immune cells associated with immune suppression. Importantly, the investigators confirmed that the colorectal cancer cells themselves did not produce detectable CTHRC1. Instead, the protein was found primarily in fibroblasts and other stromal components surrounding the tumor. This finding indicates that the tumor-promoting effects originated from the tumor microenvironment rather than from the cancer cells directly. Histological analyses further revealed striking differences in tumor structure. Tumors from CTHRC1-deficient mice contained fewer cells and showed evidence of regression, while tumors in normal mice remained densely cellular and continued to expand. Full press release - https://www.oncotarget.com/news/pr/protein-in-tumor-microenvironment-found-to-promote-colorectal-cancer-growth-and-immune-evasion/ DOI - https://doi.org/10.18632/oncotarget.28878 Correspondence to: Sergey Ryzhov - Sergey.Ryzhov@mainehealth.org; Volkhard Lindner- Volkhard.Lindner@mainehealth.org; Michaela R. Reagan - Michaela.Reagan@mainehealth.org Abstract video - https://www.youtube.com/watch?v=gTbYy6vGd7E To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM
In this special episode of Takeaway Chinese, we're going to learn how to say "abstract" in Chinese.
The Emperor Julian with Jeremy SwistWe are thrilled to welcome Assistant Professor Jeremy Swist back to the show to discuss all things emperor Julian! Julian's rule as Roman emperor was short, but it also created quite a stir because Julian was keen to turn Rome away from Christianity and to bring back the paganism. How did he do it? Why did he do it? And what's the legacy that he left behind? We consider the details.Jeremy Swist has a PhD in Classics from the University of Iowa, and his research interests include imperial Greek and Roman historiography and rhetoric, late antiquity, classical reception in heavy metal music. He is currently Assistant Professor of Classical Studies at Michigan State University. Jeremy has published and presented extensively, and he has a particular interest in the intersection of heavy metal music and the classical world - we suggest you check out his blog, Heavy Metal Classicist, or our previous episode with him to find out more. In 2024, he translated and produced a dramatic reading of the Emperor Julian's Symposium of the Caesars, which starred some of the finest podcasters and actors in the WORLD! (Maybe us)The Emperor Julian, who ruled Rome between 361 and 363 CE, is one of Jeremy's great passions, and we are thrilled to talk to him about his new volume on this unusual ruler. The book is published by Oxford University Press and is entitled Julian Augustus: Platonism, Myth, and the Refounding of Rome.Abstract from Oxford University Press“The Roman emperor Julian employed both words and deeds to return the empire to paganism and reverse Christianization, inspired by his conversion to the Neoplatonic philosophy and radical pagan Hellenism of Iamblichus, and promoted by his own production of Greek literature. These works present a coherent vision of the providentially guided history and destiny of Rome as a series of (re)foundations enacted by rulers such as Romulus, Numa, and Augustus. Julian offers an Iamblichean approach to interpreting Roman legends, Platonic allegories, and myths of his own creation to articulate his own role in the refounding of the empire. Approaching the wider examination of Julian's imperial self-image on these terms ends up nuancing and challenging common assumptions influenced by the rhetoric of his contemporary proponents. In his reverence for the gods and for philosophy, the emperor's self-construction embraces the identities of a statesman and solider more than philosopher, Roman more than Greek, and mere human rather than semi-divine being. Julian's unique positionality as emperor let him invert the conventions of panegyric whereby rulers equal and surpass the demigods and heroes of myth and history. While distancing himself from the ideal models of virtue and founding that inspire him, he adopts a different set of exemplary figures as mirrors of himself. Statesmen such as Pericles and Scipio, and especially Augustus, serve as precedents for Julian's more realistic conception of his role in refounding the empire, as student and champion of philosophers, guardian of law and tradition, and servant of the gods.”The return to the old godsJulian's rule was short but it left quite an impact. We chat with Jeremy about some of the ideas Julian put forward about Rome, the foundation stories that underpinned its self-definition, and what might have been if weren't for an unfortunate spear that wounded Julian and ended his life just two years into his reign.Sound CreditsOur music is by the superb Bettina Joy de Guzman.For our full show notes and edited transcripts, head on over to https://partialhistorians.com/Support the showPatreonKo-FiRead our booksRex: The Seven Kings of RomeYour Cheeky Guide to the Roman Empire Hosted on Acast. See acast.com/privacy for more information.
Das Leben läuft oft anders als erhofft: Trennung, Krankheit oder Enttäuschungen werfen uns aus der Bahn. In dieser "Achtsam" klären wir, wie wir uns schmerzenden Gefühlen nähern und warum Akzeptanz uns wieder handlungsfähig machen kann.**********Quellen aus der Folge:Abstract zu: Aldao, A., Nolen-Hoeksema, S., & Schweizer, S. (2010). Emotion-regulation strategies across psychopathology: A meta-analytic review. Clinical psychology review, 30(2), 217-237.Abstract zu: Witvliet, C. V. O., Ludwig, T. E., & Laan, K. L. V. (2001). Granting forgiveness or harboring grudges: Implications for emotion, physiology, and health. Psychological science, 12(2), 117-123.Witvliet, C. V. O., Ludwig, T. E., & Laan, K. L. V. (2001). Granting forgiveness or harboring grudges: Implications for emotion, physiology, and health. Psychological science, 12(2), 117-123.**********Mehr zum Thema bei Deutschlandfunk Nova:Akzeptanz und Psyche: Einfach mal wahrnehmenStimmungsbarometer: Wie Moodtracking uns helfen kannAkzeptanz- und Commitment-Therapie: Partnerschaften achtsam gestalten**********Den Artikel zum Stück findet ihr hier.**********Ihr könnt uns auch auf diesen Kanälen folgen: TikTok und Instagram .**********Ihr habt Anregungen, Ideen, Themenwünsche? Dann schreibt uns gern unter achtsam@deutschlandfunknova.de
All links here: https://hunterwilliamshealth.com/linksTimestamps:00:00 Intro01:00 Why I'm making this video04:00 The plan: peptides with direct anti-cancer evidence06:02 AOD-9604 and HGH Frag 176-19107:42 BPC-15709:54 DSIP (Delta Sleep Inducing Peptide)11:08 Epitalon12:30 Follistatin 34413:30 GHK-Cu14:36 Kisspeptin15:58 KPV17:18 LL-3718:46 Melanotan 219:58 MOTS-c21:12 Retatrutide22:34 Semaglutide23:40 SS-3124:38 Thymalin25:26 Thymosin Alpha-127:00 Tirzepatide27:30 VIP (Vasoactive Intestinal Peptide)28:06 Bottom line and closing thoughtsDescriptionIf you spend any time in the peptide social media world, you've heard it. "Peptides cause cancer." It's the easiest way to scare someone off something, and a lot of people do it without ever showing you a single study.So I went and pulled the studies. In this video I walk through every peptide on the popular research peptide list that actually has direct anti-cancer evidence in the published literature. Not theory. Not mechanism guesses. Actual studies in cells, animals, and in some cases, humans.You'll see what the research says about BPC-157, GHK-Cu, Epitalon, KPV, LL-37, Thymosin Alpha-1, MOTS-c, semaglutide, tirzepatide, retatrutide, and a handful more. Some of this evidence is strong. Some is preliminary. I'm honest about both.This is not medical advice and I'm not telling you peptides cure cancer. That's not what the data says and that's not what I'm claiming. What I am saying is that the next time someone hits you with a 60 second clip telling you peptides cause cancer, you'll have something more substantial to weigh it against.All study links below.
Let's practice some common Spanish abstract nouns, including nombre, tipo, historia, and poco. Practice all of today's Spanish for free at LCSPodcast.com/74
Interactive social media site Status announced Tuesday $17 million in combined seed and Series A funding, with investors including General Catalyst, YC, LightShed Ventures, and Abstract. Also, Stilta announced Tuesday a $10 million seed round led by Andreessen Horowitz. Other investors in the round include YC and operators from companies like OpenAI, Legora, and Lovable. Learn more about your ad choices. Visit podcastchoices.com/adchoices
In this episode of Diving Into Diets on Bovine Science with BCI, Dr. Brad White and Dr. Todd Gunderson discuss a 2026 study on the high prevalence of bovine leukemia virus in cow-calf operations, implications for cow reproduction, culling, and calf weight. The conversation concludes there is not a great association between culling risk and pregnancy status associated with the ELISA test. Read the article here
Where Peter is? Turning your son in to justice? Abstract religion? Join us for Open Line Monday with Fr. John Trigilio.
This week, Wes and Todd talk with Colorado Springs Artist, Jes Moran. Jes discusses her engagement with art as a child, growing up in Wisconsin, altering clothes & studying apparel design, her compulsion to make, loving process, having an intentional art practice the past five years, creative ideas, some of the other creative pursuits that she explored before doing the work she does now, being self-taught, learning to trust herself, her process, being fearless, quilts, sewing, what art does for her, letting go, her older work, titles, negative space, abstract art, experimentation & exploration, finding her voice, writing, space, memories, family, vulnerability, self-doubt, routine, sacrifices, potato chips, color, her new work, her show at Auric in June, being seen & valued, the support of her family, the Colorado Springs art community, and her idea of perfect happiness.Join us for a wonderful conversation with Jes Moran!Check out Jes Moran's exquisite work at www.jesmoran.comFollow Jes Moran on social media:Instagram - www.instagram.com/jesdmoran/ - @jesdmoranJes' exhibition “Seam Shift: painting through construction” will be on display at Auric Gallery through the month of June. Opening reception June 5th. For more information go to www.auricgallery.comSend us Fan MailFollow us on Instagram:@tenetpodcast - www.instagram.com/tenetpodcast/@wesbrn - www.instagram.com/wesbrn/@toddpiersonphotography - www.instagram.com/toddpiersonphotography/ Follow us on Facebook:www.facebook.com/TenetPodcast/Email us at todd@toddpierson.com If you enjoyed this episode or any of our previous episodes, please consider taking a moment and leaving us a review on your favorite podcast platform.Thanks for listening!
Most communication is misunderstood by default.I break down why INFPs and ISTJs keep missing each other even when they care deeply, and what you can actually do to fix it. If you've ever felt like your partner just doesn't “get” you, this will clarify what's happening under the surface.In this video, I go into how communication gets filtered through personal meaning, why abstract ideas and feelings often get distorted, and how cognitive functions create friction in relationships. I also show how INFPs can adjust their approach without betraying themselves.You'll learn:Why “understanding” is often an illusionHow INFP and ISTJ functions clash in communicationWhat role assumptions and mind-reading playHow to use feedback and clarity to reduce conflictA simple shift using your tertiary functionThe exact question that cuts through confusionIf you want better communication, less frustration, and more alignment in your relationship, this gives you a practical way forward.If this helped, subscribe for more on personality, relationships, and leveling up your inner characters.Like the video if you've experienced this. It helps more people see it.Drop a comment with your experience. INFP, ISTJ, or something else.0:00 Most communication is miscommunication0:32 Why your words get interpreted differently1:28 Abstract ideas always get distorted2:15 Stop assuming they understand you3:05 Mind reading is breaking your relationship4:05 Take responsibility for being understood5:05 INFP cognitive functions (Soul, Explorer)6:35 ISTJ cognitive functions (Guardian, Commander)8:10 Why INFP vs ISTJ naturally clash9:45 Why your advice feels wrong to them11:20 Why their advice feels wrong to you12:45 The “function mismatch” problem13:40 Fix #1: Use your Guardian (Si)14:40 Fix #2: Get specific and clarify15:40 The question that fixes misunderstanding
Artur Dron is a 25-year-old Ukrainian poet, essayist, and combat veteran. Born in Ivano-Frankivsk Oblast in western Ukraine. Graduated from the Department of Journalism at Ivan Franko National University of Lviv. Before the full-scale invasion, worked as event manager at The Old Lion Publishing House in Lviv — the publisher that would later issue Hemingway Knows Nothing. Saw combat across Donetsk, Kharkiv, and Zaporizhzhia oblasts. Seriously wounded in October 2024 by an anti-personnel mine. Endured multiple surgeries and a nerve transplant after shrapnel injuries. Demobilised in July 2025 due to disability — discharged on 4 July 2025, completing service that began on 2 March 2022. His poetry has been translated into at least ten languages.----------BOOKS: Dormitory №6 (2020) We Were Here (2023)Hemingway Knows Nothing (2025)LINKS:https://warpoetryukraine.org/https://pen.org.ua/en/members/dron-arturhttps://ukraineworld.org/en/articles/stories/poetry-ukrainianhttps://chytomo.com/en/review-of-artur-dron-s-book-hemingway-knows-nothing/https://www.arrowsmithpress.com/journal/artur-dronhttps://book.artarsenal.in.ua/en/guest-2023/artur-dron-2/To purchase Artur's book of poetry in UK: https://www.jantarpublishing.com/product-page/we-were-here----------SUPPORT THE CHANNEL:https://www.buymeacoffee.com/siliconcurtainhttps://www.patreon.com/siliconcurtainhttps://www.gofundme.com/f/scaling-up-campaign-to-fight-authoritarian-disinformation----------ACTIVE CAMPAIGN:We are raising funds for 5 of 15 Vampire DronesSilicon Curtain for Kupiansk Vampires. Dzyga's Paw, together with Jonathan Fink, is joining forces to raise $40,000 to provide the Khartiia Brigade with Vampire Drones.https://dzygaspaw.com/silicon-curtain-for-kupiansk-vampiresThese heavy bombers are designed to destroy manpower and equipment, as well as for remote mining. The Vampire UAV, manufactured by Skyfall, has proven itself to be one of the most effective weapons in the Kupiansk direction. Skyfall is one of Ukraine's largest defense tech companies, producing Vampire bomber drones, various modifications of Shrike FPV drones, P1-SUN, Shahed drone interceptors, communication systems, and components.https://dzygaspaw.com/silicon-curtain-for-kupiansk-vampires----------TRUSTED CHARITIES ON THE GROUND:Car4Ukrainehttps://car4ukraine.com/en-US/campaignsDzyga's Pawhttps://dzygaspaw.com/projectsSuperhumans - Hospital for war traumashttps://superhumans.com/en/UNBROKEN - Treatment. Prosthesis. Rehabilitation for Ukrainians in Ukrainehttps://unbroken.org.ua/Come Back Alivehttps://savelife.in.ua/en/Chefs For Ukraine - World Central Kitchenhttps://wck.org/relief/activation-chefs-for-ukraineUNITED24 - An initiative of President Zelenskyyhttps://u24.gov.ua/Serhiy Prytula Charity Foundationhttps://prytulafoundation.orgNGO “Herojam Slava”https://heroiamslava.org/----------PLATFORMS:Substack: https://substack.com/@siliconcurtainTwitter: https://twitter.com/CurtainSiliconLinkedin: https://www.linkedin.com/in/finkjonathan/Podcast: https://open.spotify.com/show/4thRZj6NO7y93zG11JMtqm----------
Song Talk Radio | Songwriting Tips | Lyrics | Arranging | Live Feedback
We chatted with Montreal-based artist Avril Jensen about writing an abstract song from personal experience. Download the lyrics to Dog (everybody learns) to follow along. We talked about: Songwriting Challenge 2026: Write a Traditional Country Song Writing musically interesting melodies that are still catchy Writing the lyrics based on personal experience with actual dogs, but maybe it's also a metaphor for a toxic relationship 80s French Canadian band The Box Does music theory get in your way of keeping things simple?… Read the rest
Peter A. Kirby is a world-renowned independent researcher, investigative author, and activist specializing in deep dives into suppressed and controversial subjects. His groundbreaking work on geoengineering and weather modification has earned him international recognition. Peter is the author of "Chemtrails Exposed: A New Manhattan Project", widely regarded as the most comprehensive book on the subject. He hosts The Abstract on Rumble and provides sharp social commentary on TruthSocial. His research has been translated into every major language and featured across major alternative media platforms.Watch the Cornerstone Forum 26'https://shaunnewmanpodcast.substack.com/Silver Gold Bull Links:Website: https://silvergoldbull.ca/Email: SNP@silvergoldbull.comText Grahame: (587) 441-9100Bow Valley Credit UnionBitcoin: www.bowvalleycu.com/en/personal/investing-wealth/bitcoin-gatewayEmail: welcome@BowValleycu.com Get your voice heard: Text Shaun 587-217-8500
This episode covers a wide range of topics across betting, prediction markets, and probabilistic thinking. We start with the Brendan Sorsby situation after reports surfaced about a major gambling-related issue involving the Texas Tech QB, including over 10,000 bets placed dating back to 2022. The conversation focuses on what this means for gambling integrity in college sports and the broader responsibility discussion that comes with it. From there, the panel reacts to Isaac Rose-Berman's recent article on prediction markets and the way they are positioned as an alternative to traditional sportsbooks. The discussion explores whether that framing is accurate, how these platforms actually generate profit, and what bettors often misunderstand about their structure. The group also breaks down a viral take from Plus EV Analytics on parlay thinking and how human intuition struggles with probability when outcomes are layered together. Host Jacob Gramegna is joined throughout the episode by Joey Knish, Isaac Rose-Berman, and Chris Dierkes (Flupnolide), a trader at Novig, with all four contributors involved in the full discussion across gambling, markets, and bettor psychology.
BUFFALO, NY – April 29, 2026 – A new #research paper was #published in Volume 17 of Oncotarget on April 28, 2026, titled “Targeted therapeutics and U.S. population-level mortality trends in multiple myeloma: A SEER-based analysis from 1975 to 2023.” The study was led by first and corresponding author Navkirat Kahlon from the Mass General Cancer Center at Wentworth-Douglass Hospital, in collaboration with researchers from multiple U.S. institutions. In this study, the researchers examined how mortality trends in multiple myeloma have changed in the United States over nearly five decades, using population-level data from the SEER database. Multiple myeloma, a cancer of plasma cells, has historically been associated with poor survival outcomes, but treatment options have evolved dramatically over time. The analysis revealed a clear shift in mortality trends that closely parallels major therapeutic advances. Between 1975 and the mid-1990s, mortality rates steadily increased, reflecting the limited effectiveness of early treatments such as alkylating agents and corticosteroids. A turning point emerged in the 1990s with the introduction of autologous stem cell transplantation, which marked the first meaningful improvement in survival outcomes. Over the following years, the development of targeted therapies—including immunomodulatory drugs and proteasome inhibitors—was associated with a more pronounced decline in mortality. These treatments introduced new mechanisms of action, such as immune modulation and enhanced cancer cell apoptosis, significantly improving disease control. More recent years have seen further progress with the introduction of monoclonal antibodies, maintenance therapies, and combination treatment strategies. Notably, the steepest decline in mortality occurred between 2021 and 2023, coinciding with the clinical adoption of advanced immunotherapies such as CAR T-cell therapies and bispecific antibodies. These treatments have shown the ability to induce deep and durable responses, even in heavily pretreated patients. “Our findings highlight the real-world impact of targeted therapies on population-level outcomes and underscore the urgent need for care models that ensure accessibility, affordability, and long-term sustainability in the era of precision oncology.” Importantly, while these therapeutic advances have improved survival, they have also introduced new challenges. Many patients now require long-term treatment, which can be associated with cumulative toxicities and a significant financial burden. In addition, access to these therapies remains uneven, influenced by geographic, socioeconomic, and healthcare system factors. Overall, this study provides a comprehensive, real-world view of how advances in cancer treatment have translated into measurable improvements in survival at the population level. At the same time, it highlights the need to ensure that these benefits are both sustainable and accessible to all patients as the field continues to evolve. DOI - https://doi.org/10.18632/oncotarget.28877 Correspondence to - Navkirat Kahlon - nkahlon@mgb.org; (ORCID: https://orcid.org/0000-0003-1115-2029) Abstract video - https://www.youtube.com/watch?v=-TNWkG9FyUo Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us on social media: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM
Join host Emily Walsh Martin, PhD, as she hands the baton to the new co-hosts of The Issue podcast, Sanjay D’Souza, PhD, and Jason West, PhD. Listen in as the three preview some of the abstracts that will be presented at the ASGCT 2026 Annual Meeting, held May 11-15 in Boston, MA. Music: ‘Bright New Morning’ by Steven O’Brien – released under CC-BY 4.0. https://www.steven-obrien.net/Show your support for ASGCT!: https://asgct.org/membership/donateSee omnystudio.com/listener for privacy information.
Featuring an interview with Dr Natalie Vokes, including the following topics: Perioperative minimal residual disease (MRD) detected by circulating tumor DNA (ctDNA) testing in patients with lung cancer (0:00) Ohara S et al. Clinical significance of perioperative MRD detected by ctDNA in patients with lung cancer with a long follow-up data: An exploratory study. JTO Clin Res Rep 2024;6(3):100762. Abstract Masuda K et al. MRDSEEKER (JCOG2111A): A prospective study to evaluate MRD and its association with prognosis in curative-intent NSCLC. World Conference on Lung Cancer 2025;Abstract P3.18.04. Zhou C et al. IMpower010: Biomarkers of disease-free survival in a phase 3 study of atezolizumab vs best supportive care after adjuvant chemotherapy in stage IB-IIIA NSCLC. ESMO IO 2021;Abstract 2O. MRD analysis of adjuvant therapy with osimertinib for resected EGFR-mutated Stage IB to IIIA non-small cell lung cancer (NSCLC) (8:28) Herbst RS et al. Molecular residual disease analysis of adjuvant osimertinib in resected EGFR-mutated stage IB-IIIA non-small-cell lung cancer. Nat Med 2025;31(6):1958-68. Abstract MRD analyses of perioperative chemoimmunotherapy for resected NSCLC (15:12) Forde PM et al. Overall survival with neoadjuvant nivolumab plus chemotherapy in lung cancer. N Engl J Med 2025;393(8):741-52. Abstract ctDNA dynamics in advanced NSCLC treated with immunotherapy (20:56) Vokes NI et al. Circulating tumor DNA (ctDNA) dynamics and survival outcomes in patients (pts) with advanced non-small cell lung cancer (aNSCLC) and high (>50%) programmed cell death ligand 1 (PD-L1) expression, randomized to cemiplimab (cemi) vs chemotherapy (chemo). ASCO 2023;Abstract 9022. Anagnostou V et al. ctDNA response after pembrolizumab in non-small cell lung cancer: Phase 2 adaptive trial results. Nat Med 2023;29(10):2559-69. Abstract Anagnostou V et al. A biomarker-directed, multi-center phase II/III study of ctDNA molecular response adaptive immuno-chemotherapy in patients with non-small cell lung cancer (BR.36). ASCO 2025;Abstract TPS8669. CME information and select publications
Livi by LiviWell is an FDA-cleared, single-use, soft polyurethane foam device designed to immediately absorb post-intercourse fluids (semen) to support vaginal health. Inserted like a tampon within 15 minutes post-coitus, it works in roughly 60 seconds to restore natural pH, helping to manage odor, dripping, and discomfort. Is this evidence-based? Listen in for details.1. https://www.biospace.com/press-releases/liviwell-secures-fda-clearance-for-livi-introducing-a-new-category-in-post-intercourse-vaginal-care#:~:text=Advertise-,LiviWell%20Secures%20FDA%20Clearance%20for%20Livi%2C%20Introducing%20a%20New%20Category,and%20other%20post%2Dintercourse%20fluids.2. Mngomezulu K, Mzobe GF, Mtshali A, et al. Recent Semen Exposure Impacts the Cytokine Response and Bacterial Vaginosis in Women. Frontiers in Immunology. 2021. 3. Abstract: ISSWSH/ISSM Joint Meeting 2025. Abstract citation ID: qdaf068.138 (155) SEMEN IS NOTTHEVAGINA'SFRIEND:ANOVEL POST-SEX TAMPON IMPROVES VAGINAL HEALTH PARAMETERS