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In part one, Dr. Liz Bartman and I broke down why PMDD happens: the histamine surges, the GABA receptor glitch, the progesterone metabolite that either calms you down or completely wrecks you depending on your unique biology. If you haven't listened to that one yet, start there, because this episode builds directly on it. Now we get into the part everyone actually wants to know: what do you do about it? We talk about why popular fixes like DAO supplements and strict low histamine diets usually fall short, and what to focus on instead, starting with your gut, your liver, and your nervous system. Dr. Liz walks through her actual clinical protocols, including specific nutrients, herbs, and the EndoAccess formulas she uses with patients who have histamine overload, progesterone sensitivity, or both. We also get into the harder conversations: when a 5-alpha reductase inhibitor might help women who are pushing too much allopregnanolone, what's really going on hormonally for women hitting perimenopause with worsening PMDD, and yes, when birth control or even an SSRI might actually be the safest, most compassionate choice, even for someone who leans natural. Dr. Liz makes a case that will challenge how you think about "first, do no harm." This episode is about giving you an actual roadmap, not just information. Because once you understand your own biology, from part one, you can finally stop guessing and start treating the right thing. In This Episode, We Cover: Why DAO supplements and strict low histamine diets usually don't solve the problem long term The gut, liver, and nervous system focused approach Dr. Liz uses first with patients Key nutrients and antioxidants for calming histamine and neuroinflammation, including glutathione support, sulforaphane, green tea, pomegranate, curcumin, NAC, and glycine Why alcohol is one of the biggest hidden disruptors of histamine clearance and hormone balance Specific probiotic strains, including lactobacillus plantarum, and their surprising role in GABA receptor expression The EndoAccess formulas Dr. Liz uses clinically for histamine support and for progesterone sensitive PMDD, including early results from a small group of patients What 5-alpha reductase inhibition is, how it relates to allopregnanolone, and when it may help Why perimenopausal women can suddenly develop worse PMDD, and the surprising role of testosterone, insulin, and FSH The honest conversation about birth control, newer options, and when it may be the safest choice for severe PMDD Where SSRIs fit in, including luteal phase only dosing and what to support alongside them Why the nervous system piece is the part most women skip, and why it may be the most important one Who This Episode Is For This is for women who now understand why they're struggling, from part one, and want an actual plan. It's for anyone who has tried supplements or progesterone with no luck and felt like they were out of options. It's especially for women in perimenopause noticing their PMDD or PMS getting dramatically worse, and for anyone who has felt conflicted about whether birth control or an SSRI could ever be the "right" choice for them. Sponsors Join the Midlife Women's Peptide Program today and get started for less than $200 a month! Timeline is offering up to 39% off your first order of Mitopure. Gummies. Go to timeline.com/HORMONE use coupon HORMONE Get 15% off Magnesium Breakthrough By BiOptimzers at bioptimizers.com/hormone with coupon code HORMONE. Are you in perimenopause or postmenopause and struggling with symptoms—but not getting the support you deserve? At Midlife Solutions, we specialize in hormone optimization for women in midlife. Our all-female clinical team offers telehealth care across all 50 U.S. states, with the ability to prescribe bioidentical estrogen, progesterone, testosterone, and thyroid medication. Book your FREE Hormone Discovery Call Find out what's really driving your symptoms and what your next best steps are. Visit the website: https://karenmartel.com Shop the Midlife Solutions Store Over-the-counter bioidentical hormone creams and oils — no prescription needed. Including: • Progesterone • Estrogen Face Cream • Vaginal Moisturizer and more! Take the Hormone Quiz Discover hidden hormone imbalances that could be driving your symptoms. Get personalized results (and yes, they may surprise you). Women's Peptide Weight Loss Program Clinically guided, hormone-aware weight loss for midlife women. Midlife RESET HRT Program A complete, supportive approach to hormone replacement therapy in midlife. Your host: Karen Martel Certified Hormone Specialist, Transformational Nutrition Coach, & Weight Loss Expert Karen's Facebook Karen's Instagram
About this episode: Selective serotonin reuptake inhibitors, or SSRIs, are the most widely used class of antidepressants. While these medications have undoubtedly saved lives, they have also gained scrutiny for having significant side effects and being difficult to taper off of. In this episode: Two psychiatrists talk about the existing recommendations for deprescribing and why SSRIs remain a critical treatment tool despite pressure from federal health officials to wean Americans off of them. Guest: Dr. Paul Nestadt is an associate professor of Mental Health who studies the epidemiology of suicide and serves as the primary supervising psychiatrist for the Johns Hopkins Hospital Anxiety Disorders Clinic. Dr. Jimmy Potash, MPH, is the director of Psychiatry and Behavioral Sciences and psychiatrist-in-chief at Johns Hopkins Medicine. Host: Stephanie Desmon, MA, is a former journalist, author, and the director of public relations and communications for the Johns Hopkins Center for Communication Programs. Show links and related content: Kennedy Starts a Push to Help Americans Quit Antidepressants—The New York Times Prescriptions for Antidepressants Increasing among Individuals with no Psychiatric Diagnosis—Johns Hopkins Bloomberg School of Public Health Tapering of SSRI treatment to mitigate withdrawal symptoms—Lancet Psychiatry Changes in antidepressant use by young people and suicidal behavior after FDA warnings and media coverage: quasi-experimental study—BMJ Cognitive Behavior Therapy for Generalized Anxiety Disorder Among Older Adults in Primary Care—JAMA Transcript information: Looking for episode transcripts? Open our podcast on the Apple Podcasts app (desktop or mobile) or the Spotify mobile app to access an auto-generated transcript of any episode. Closed captioning is also available for every episode on our YouTube channel. Contact us: Have a question about something you heard? Looking for a transcript? Want to suggest a topic or guest? Contact us via email or visit our website. Follow us: @PublicHealthPod on Bluesky @PublicHealthPod on Instagram @JohnsHopkinsSPH on Facebook @PublicHealthOnCall on YouTube Here's our RSS feed Note: These podcasts are a conversation between the participants, and do not represent the position of Johns Hopkins University.
To Find Deplorable Janet--> https://open.spotify.com/show/3K5Xi9LugxNdI06GXSIjAp?si=m5hPD7OsS6eim1jACk84ewTo sign up for our Patreon go to-> Patreon.com/cultofconspiracypodcast To find the Meta Mysteries Podcast---> https://open.spotify.com/show/6IshwF6qc2iuqz3WTPz9Wv?si=3a32c8f730b34e79 To Join the Cajun Knight Patreon---> Patreon.com/cajunknight To Find The Cajun Knight Youtube Channel---> click herehttps://flavorsforest.com/cult/Become a supporter of this podcast: https://www.spreaker.com/podcast/cult-of-conspiracy--5700337/support.
Dr. Tyler Panzner joins Dr. Mike Hart to explain how genetics, supplement combinations, and individual brain chemistry can influence anxiety, irritability, brain fog, and the persistent "monkey on your back" feeling. They examine why the MTHFR gene is scientifically valid but often overmarketed, and why methylated B vitamins, SAMe, creatine, phosphatidylcholine, and other methylation-related supplements may help some people while overstimulating others. The conversation also explores hidden "adrenaline trappers" such as quercetin, polyphenols, and greens powders; why NAC, glutathione, and high-dose antioxidants may cause unwanted effects; and how lithium orotate, melatonin, nicotine, methylene blue, omega-3s, collagen, mitochondrial enhancers, and DHT-lowering supplements can affect people differently. Dr. Panzner also discusses pharmacogenomics, SSRI response, supplement timing around exercise, the limitations of genetic testing, and the importance of combining DNA data with bloodwork, symptoms, medication history, and baseline nutrient status. Dr. Tyler Panzner is a pharmacology and genetics expert whose work focuses on personalized supplementation, genetic testing, neurotransmitter pathways, and understanding why the same health intervention can affect people very differently. Through DNA analysis, laboratory review, supplement audits, and individualized coaching, he helps clients identify which biological pathways may need support and which commonly recommended supplements may be working against them. His approach challenges one-size-fits-all biohacking and emphasizes using genetics, bloodwork, symptoms, and personal response patterns to make more informed decisions about mental health, performance, and long-term wellness. Work with Dr. Tyler Panzner! Unlock Your Genetic Potential — Dr. Tyler Panzner https://drtylerpanzner.com/ Dr. Tyler Panzner on Instagram — Tyler Panzner https://www.instagram.com/drtylerpanzner/ Quieting an Overactive Mind Webinar — Tyler Panzner https://overstimulated.drtylerpanzner.com/webinar-registration-page Show Notes 00:00 Welcome to the Hart2Heart Podcast 00:47 MTHFR Hype vs Reality 02:14 Methylated Bs and Anxiety 03:48 Creatine Choline and SAMe 07:43 Beyond One Gene Test 11:14 Lithium Orotate Basics 15:18 Supplements That Backfire 17:36 Antioxidant Overload Effects 21:01 Melatonin Dose Debate 23:56 Antioxidants Around Workouts 26:48 Collagen What Actually Works 30:07 SSRIs and Genetic Fit 34:23 Herbal SSRI Alternatives 37:18 DHT Lowering Side Effects 41:54 Biohacking Marketing Hype 43:25 Fish Oil Mood Ratios 46:16 Oral Nicotine Tradeoffs 52:03 Methylene Blue Risks 54:46 Mitochondria Boosters Anxiety 57:13 Greens Powders Overstimulation 01:01:04 Magnesium Forms For Sleep 01:04:51 DNA Testing And ChatGPT 01:12:23 Genetics For Caffeine Sensitivity 01:16:23 Psychedelics And DNA 01:18:50 Coaching Logistics Wrap Up The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart
Millions of women take SSRIs for anxiety and depression and many times no one tells about the sexual side effects, let alone that there's a solution. When it happened to a sex therapist and an OB-GYN themselves, they refused to accept "just add Wellbutrin" as the only answer. Dr. Laurie Mintz and Dr. Suzette Johnson join Dr. Rahman to share the deeply personal stories behind their new venture and why no woman should have to choose between her mental health and her sexual health.What started as a friendship between "sisters from another mother" became a mission after both women personally experienced SSRI-induced orgasm dysfunction and discovered how well a compounded topical cream made with sildenafil and L-arginine worked for them. Now, in partnership with Mojo, they've launched something no one else is offering: the cream plus a short course covering the biological and psychological sides of orgasm dysfunction mindfulness, vibrators, erotica, and the science of why your body responds the way it does.The conversation also dives deep into the orgasm gap: why women orgasm 22–33% less often than men in heterosexual encounters, what the research on bisexual women reveals about whose "fault" that really is (hint: it's not women's bodies), and the brand-new concept of the orgasm pursuit gap why women need to start actively pursuing their own pleasure without pressure.This is midlife reinvention, medical advocacy, and orgasm equality all in one conversation.Highlights:SSRIs are essential medication for many women but sexual side effects like muted or absent orgasm are real, common, and rarely disclosed at the time of prescribing.Most prescribers' only answer is "add Wellbutrin"—few know that a compounded topical cream (sildenafil + L-arginine) can restore blood flow, sensation, and orgasm for many women.New research identifies an orgasm pursuit gap heterosexual women largely don't pursue their own orgasm or expect their partners to.Pursuit is not pressure: women can actively seek the clitoral stimulation they need without turning orgasm into a performance demand.Sexuality does not expirewomen can and should stay sexually active at every age if they want to be.Remember: I'm here to educate so you can advocate for yourself. This podcast is for education, not medical advice please see your own doctor or clinician for your individual care.Please make sure to share this episode with women who would find it helpful. Most of this information is still new to many women and the more it gets shared the more women we are helping!Get in Touch with Dr. Mintz & Dr. Johnson::Dr. Mintz- WebsiteDr. Johnson:Mojo Get in Touch with Dr. Rahman:WebsiteInstagramYoutubeSubstack
I just wrapped my first year of my 30s, and I'm sharing the 30 biggest lessons I learned along the way. From de-centering your age to normalizing changing your mind to finally getting your money basics right, this is everything I wish someone had told me in my 20s. If you feel like you're racing a deadline that isn't even real, this one's for you.What I cover:
In this episode of the Psychedelic Medicine Podcast, Dori Lewis, MA, MEd, LPC-S returns to discuss the differences between psilocybin and ketamine. Dori is the Clinical Director of Elemental Psychedelics and Owner/Operator of Reflective Healing in Fort Collins Colorado. As a clinician, she blends transpersonal psychology, depth work, and psychedelic-assisted therapy within a model that centers the therapeutic relationship. To date, she has stewarded over 100 ketamine therapy sessions, more than 200 mushroom sessions, and numerous group ceremonies. In this conversation, Dori explores how clinicians and facilitators can thoughtfully decide when ketamine or psilocybin may be the more appropriate therapeutic option, emphasizing that the two medicines are complementary rather than competing approaches. She explains how factors such as current medications, trauma history, substance use, prior experience with altered states, therapeutic readiness, and available social support all shape this decision. Throughout the discussion, Dori argues that ketamine often serves as an accessible and effective introduction to psychedelic-assisted therapy, while psilocybin may be especially valuable for addressing grief, attachment and religious trauma, and deeper existential questions when paired with sufficient preparation, integration, and a strong therapeutic relationship. In this episode, you'll hear: Why ketamine is often recommended before psilocybin for people new to psychedelic therapy How SSRIs and other medications influence the choice between ketamine and psilocybin What personal history, symptoms, and therapeutic readiness clinicians should evaluate before recommending either medicine Which conditions and life experiences may be particularly well-suited for psilocybin-assisted therapy, including grief, attachment trauma, and existential distress How cannabis use, substance use disorders, and suicidal ideation can affect treatment planning Why community support, integration resources, and a trusting relationship with a facilitator are critical for successful psychedelic experiences The importance of cultivating self-awareness before engaging in psychedelic-assisted therapy Quotes: "How do we help somebody who is on these [SSRI] medications, has been on them for a really long time and is actually doing well with them? The answer is not to get someone to stop taking their meds just to have a psilocybin experience. That's actually really reckless, in my opinion. What I would say is, why don't we start with ketamine and see how that affects you." [7:59] "There's another important piece here: What [does the patient] want? If this person says, 'Dori, I really don't want to do ketamine. I want to work with a plant medicine. That's what I'm feeling really called to.' I might say, 'okay, then let's explore that.' But if they're open [to either], I might say, 'why don't we start with [ketamine]?'" [15:50] "There are very few cases that I would say, 'don't start with ketamine' unless somebody says 'I've already done ketamine' … or they say 'I don't want to do ketamine' but in most cases I'm going to recommend just start with ketamine" [23:05] Links: Dori on LinkedIn Elemental Psychedelics website Elemental Psychedelics on LinkedIn Reflective Healing website Reflective Healing on LinkedIn Reflective Healing on Instagram Fireside Project website Previous episode: Common Psilocybin Myths & Misconceptions with Dori Lewis, LPC Previous episode: How Psychedelics & Pharmaceuticals Can Both Aid Healing with Erica Zelfand, ND Psychedelic Medicine Association Porangui
The pharmaceutical industry has perfected this model: drugs are designed to be taken perpetually rather than cure, side effects create demand for additional drugs, and the entire regulatory apparatus is structured to suppress affordable natural therapies that challenge it SSRIs epitomize this dynamic — massively overprescribed, frequently life-ruining, and nearly impossible to withdraw from — yet for decades, the industry successfully kept all criticism of them out of mainstream discourse Kennedy announced a multiagency federal effort to combat inappropriate SSRI prescribing, train providers in how to correctly taper patients off antidepressants, and provide non-pharmaceutical alternatives This marks the first time in memory a federal health initiative has aimed to help get patients off a major drug class rather than on one
Fresh from Japan, Del reflects on a country that feels like another world—yet one where the stories, questions, and lessons of the COVID era sounded remarkably familiar.Then, Jefferey Jaxen breaks down new questions surrounding sunscreen, skin cancer, vitamin D, and whether decades of public health messaging around sun exposure may be due for a closer look. Plus, the FDA is now exploring psychedelics like psilocybin and ibogaine for PTSD and depression. Is medicine finally moving beyond the SSRI era?And celebrity chef Pete Evans joins Del in The HighWire Kitchen to share the recipes, ingredients, and kitchen secrets fueling the MAHA movement—and why real food may be the ultimate health hack.Guests: Pete EvansBecome a supporter of this podcast: https://www.spreaker.com/podcast/the-highwire-with-del-bigtree--3620606/support.
At 20, Tracy Thurman was told she'd never work again. Disabled, written off, handed a lifetime sentence by the same system that put her there. The doctors had a word for what happened to her: bad luck. They were wrong. And what finally brought her back was something the government will send armed agents to seize. This isn't a conversation for people who are comfortable. It's for the ones who already feel that something is off — that the sickness around us isn't an accident, and the people selling the cure keep ending up in court.And stay to the end. Because what starts as one woman's story becomes something bigger: the reveal of where this show is going next, and who's coming with it.
Carla Delgado is a San Diego native with eight years of experience in healthcare and a master's in healthcare administration. She also has a personal story of SSRI withdrawal, and we discuss how her background in healthcare administration helped to navigate the healthcare system, which has not been that friendly for people experiencing antidepressant withdrawal. *** Thank you for being with us to listen to the podcast and read our articles this year. MIA is funded entirely by reader donations. If you value MIA, please help us continue to survive and grow. https://www.madinamerica.com/donate/ To find the Mad in America podcast on your preferred podcast player, click here: https://pod.link/1212789850 © Mad in America 2026. Produced by James Moore https://www.jmaudio.org
Mark Clermont is the CEO of Cecelia Health, and Wendi Mader is the company's Chief Commercial Officer. Cecelia is a virtual multi-specialty medical practice, licensed in all 50 states, that helps employers, payers, health systems, and life sciences companies manage chronic and cardiometabolic disease and bring down the cost of care. It's not a point solution. It's a medical practice that prescribes and manages medication (including GLP-1s, from prescribing through titration and side-effect management), runs intensive nutrition therapy, and handles behavior and lifestyle care, all through a team of RNs, RDs, certified diabetes educators, and physicians. The model is built to extend primary care, not replace it, and to coordinate across specialists instead of adding one more disconnected program.Mark and Wendi's argument is simple: chronic disease isn't winning because we lack apps or tools. It's winning because care is fragmented and nobody's tying it together. GLP-1s are making that worse before they make it better. They're the first drug class with indications spanning diabetes, obesity, sleep apnea, fatty liver, and soon addiction, which means a single patient can suddenly need four specialists who don't talk to each other. Cecelia's bet is that a multi-specialty practice can be the layer that connects all of it.We get into:Why chronic disease keeps winning even though there are more apps, tools, and wellness programs than ever, and what point solutions got wrongWhat actually happens to a patient with diabetes and high blood pressure inside Cecelia's model versus the system todayWhy GLP-1s are the first drug class to cross medical specialties, and why that's making fragmentation worse right nowThe patient on a high-dose GLP-1 and an SSRI who almost ended up in the ER, and what the direct-to-consumer prescriber missedHow the US can rank dead last among developed nations and still be the system Mark wouldn't trade for anywhere elseWhere the industry is over-indexing on AI in chronic care, and where Wendi thinks tech actually belongsThe specialty shortage, healthcare deserts, and rural-health funding, and how virtual coordinated care reaches patients brick-and-mortar can'tWhat's different for patients five years from now if Cecelia gets this right—Brought to you by: Sage Growth Partners — Value-focused strategy and marketing for growth-driven healthcare organizations. — Where to find Jared: • X: https://x.com/jaredstaylor • LinkedIn: https://www.linkedin.com/in/jaredstaylor/
Dr. Bill Sullivan is back at TYP and this was a fascinating conversation about brand-new research suggesting that there is another component to depression, other than just brain chemistry. Knowing that about a third of people suffering with depression don’t respond positively to SSRI’s and the like, for some people, this new scientific insight and awareness might be life changing. This is definitely an episode where I learned as much as you will. Enjoy.See omnystudio.com/listener for privacy information.
British-born, LA-based author and illustrator Gemma Correll had a couple of reasons to choose the motif of an amusement park for her new anxiety book, Anxietyland. One, she loves amusement parks and wanted to be able to write off a Disneyland trip as a research expedition. And also, there are so many great metaphors to be found there like emotional rollercoasters and a worry-go-round. With hilarious candor, Gemma shares her own story about fearing coyotes would eat her pets (there are no coyotes in England), taking endless flights of stairs to avoid elevators, and dealing with alcohol, who becomes a friend but not, ultimately, a good one. Secretary of Health & Human Services Robert F. Kennedy, Jr. is, to put it mildly, a skeptic of selective serotonin reuptake inhibitor (SSRI) medication, a form of meds that millions of Americans use regularly with tremendous benefit. He was once on SSRIs, went off them, then became addicted to heroin, and he believes these events are linked. He also believes they cause school shootings and cause harm to developing fetuses. There is no evidence to support this. Andrea Salinas, a Democrat who represents the 6th district in Oregon in the House of Representatives, joins us to unpack Kennedy's latest efforts to curtail SSRI use and availability and what her minority party is doing to answer the threat. Thank you to all our listeners who support the show as monthly members of Maximum Fun. Check out our I'm Glad You're Here and Depresh Mode merchandise at the brand new merch website MaxFunStore.com! Hey, remember, you're part of Depresh Mode and we want to hear what you want to hear about. What guests and issues would you like to have covered in a future episode? Write us at depreshmode@maximumfun.org. Depresh Mode is on BlueSky, Instagram, Substack, and you can join our Preshies Facebook group. Help is available right away. The National Suicide Prevention Lifeline: 988 or 1-800-273-8255, 1-800-273-TALK Crisis Text Line: Text HOME to 741741. International suicide hotline numbers available here: https://www.opencounseling.com/suicide-hotlines Help support this show and unlock bonus content! Become a member at https://maximumfun.org/joindepresh
The hardest part about antidepressants is often not the pill, it is the question you ask yourself before you ever bring it up: “Is this serious enough?” We think that question keeps too many people stuck. We are Ed Delesky (family medicine doctor) and Nicole Aruffo (nurse), and we walk through a clearer test: is depression or anxiety affecting your ability to live your life the way you want to live it?We unpack the stigma that makes mental health feel different from every other medical problem, even though it lives in the brain like anything else. We use simple, patient-friendly analogies to explain how antidepressants work: a dimmer switch turned back up, or glasses that help you see more clearly. We also cover the practical signals we look for in primary care when deciding whether it is time to consider medication for depression or anxiety: symptoms lasting weeks to months, daily function taking a hit, sleep and motivation sliding, and foundational steps like therapy, movement, and sleep support not being enough on their own.We also demystify what starting an SSRI or SNRI can feel like, including why these medications usually take six to eight weeks to show real benefits and why a subtle improvement can still be life-changing. If you worry about dependence, personality changes, or taking something forever, we address those fears directly and talk about how many people use antidepressants for a season, not a lifetime. If this conversation helps, subscribe, share it with a friend, and leave a review so more people can find care that actually works.Send us a (voice ) message with this link, we would love to hear from you. Standard message rates may apply.Support the showProduction and Content: Edward Delesky, MD, DABOM & Nicole Aruffo, RNArtwork Rebrand and Avatars:Vantage Design Works (Vanessa Jones) Website: https://www.vantagedesignworks.com/Instagram: https://www.instagram.com/vantagedesignworks?igsh=aHRuOW93dmxuOG9m&utm_source=qrOriginal Artwork Concept: Olivia Pawlowski
Ketamine Therapy, MDMA, Psilocybin, and the Science of Psychedelic Assisted Healing Most people struggling with depression, anxiety, and trauma have never felt safe in their nervous system, and the treatments they have been prescribed are making that worse. This episode breaks down the neuroscience of psychedelic therapy, why ketamine is the safest and most accessible starting point, how MDMA triggers a BDNF dependent pathway that repairs trauma all the way down to the epigenetic code, and why your antidepressant may be blocking the very brain states required for real healing. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR -Order Dr. Rabin's Book ‘A Simple Guide to Being Alive': https://apolloneuro.com/pages/a-simple-guide-to-being-alive Host Dave Asprey sits down with Dr. Dave Rabin, MD, PhD, a senior research scientist at the Florida Institute for Human and Machine Cognition, Executive Director of The Board of Medicine, and co-founder and Chief Medical Officer of Apollo Neuroscience. Dr. Rabin received his MD and PhD in neuroscience from Albany Medical College and specialized in psychiatry at the University of Pittsburgh Medical Center. He has spent 20 years studying chronic stress and non-invasive therapies for treatment-resistant illness, and his primary research on MDMA assisted therapy for severe PTSD has demonstrated that trauma can be reversed at the epigenetic level, offering a genuine path to a cure. His upcoming book A Simple Guide to Being Alive publishes June 1, 2026 and is a science-backed manual for anyone who has ever felt overwhelmed by the modern world. Dave and Dr. Rabin break down why nearly 50% of people prescribed psychiatric medication never achieve remission, why SSRIs and SNRIs physically block the brain states required for emotional healing, and why the FDA rejected MDMA therapy after three trials showed an 88% response rate. They dig into the exact BDNF pathway that makes MDMA and ketamine so transformative, how psychedelics amplify safety learning in the amygdala at the molecular level, and why trauma passes down up to 14 generations through epigenetic code that can now be measured and repaired. They also cover why your breathing rate at the doctor's office is already a stress signal nobody is reading, how your smartphone puts your nervous system into a chronic fear state before you even get out of bed, and why ketamine is the right starting point for anyone curious about psychedelic therapy right now. You'll Learn: Why nearly 50% of psychiatric patients never get better and what treatment-resistant actually means How ketamine therapy works, why it is legal in every state, and why it is the safest place to start The exact BDNF pathway through which MDMA repairs fear extinction in the amygdala How MDMA assisted therapy produces measurable epigenetic repair of the cortisol receptor gene damaged by trauma Why SSRIs and SNRIs block the insula mediated brain states required for real emotional healing Why combining serotonergic psychedelics with SSRIs puts you at risk of life-threatening serotonin syndrome Why trauma passes down up to 14 generations and what you can do to stop the cycle now Why smartphones put your nervous system into a toxic overstimulation state before the day even starts How the FDA rejected MDMA therapy after 88% of patients responded and who paid to make that happen Thank you to our sponsors! - Qualia | If you want to take the guesswork out of maintaining high NAD+ levels as you age, go to www.qualialife.com/daveNAD to get clinically proven Qualia NAD+ backed by a 100 day money back guarantee and code DAVENAD at checkout gets you an extra 15% off. - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE - OneSkin | For a limited time, try OneSkin with 15% off at oneskin.co/DAVE. - LMNT | Right now you can get a free 8-count Sample Pack of LMNT's most popular drink mix flavors with any purchase at drinkLMNT.com/dave Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Dave Rabin, Dr. Dave Rabin, Apollo Neuroscience, A Simple Guide to Being Alive, ketamine therapy, MDMA assisted therapy, psilocybin therapy, psychedelic assisted therapy, treatment-resistant depression, treatment-resistant mental illness, BDNF pathway, fear extinction amygdala, vagus nerve activation, trauma epigenetics, cortisol receptor gene, epigenetic repair, serotonin syndrome, SSRI alternatives, MDMA BDNF, ketamine BDNF, nervous system safety, autonomic nervous system, parasympathetic nervous system, generational trauma, trauma self-trust, MAPS MDMA trial, FDA MDMA rejection, pharmaceutical interference MDMA, breathing rate stress, smartphone nervous system, Apollo Neuro wearable, Board of Medicine, theboardofmedicine.org, insula cortex, psychedelic safety protocol, ketamine legal therapy, MDMA 88 percent, bottom-up learning psychedelics, trauma fractured self-trust, 14 generations trauma, stress breathing range Resources: • Order Dr. Rabin's Book ‘A Simple Guide to Being Alive': https://apolloneuro.com/pages/a-simple-guide-to-being-alive • Purchase Dr. Fotuhi's New Book The Invincible Brain: https://a.co/d/0iHCgPpL • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 01:34 – Dave Rabin Introduction 05:01 – Psychedelics and Psychiatry 08:35 – Psychedelic Safety and Dosing 14:53 – Serotonin Syndrome Warning 21:17 – Vagus Nerve and Safety 27:36 – Smartphones and Chronic Stress 34:18 – Defining Trauma 38:00 – Trauma and Epigenetics 40:23 – MDMA Cortisol Gene Repair 44:44 – Therapy vs. Medicine Alone 49:15 – FDA MDMA Rejection 55:35 – Ketamine Personal Experience 59:15 – Closing and Book Recommendation See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Jay Gunkelman goes in BLIND on a 10-year-old's EEG — no diagnosis, no story. What he finds isn't a broken brain: it's gross over-arousal with FAST alpha near 12 Hz, beta spindling up at 32 Hz that a database stopping at 30 would never see, and a left-side sympathetic source pointing at the insula. The likely complaint? Anxiety — maybe labeled OCD, maybe pushed toward an SSRI that would make this brain worse, not better. Jay lays out the actual fix: the Scott protocol's pre-treatment FIRST (calm the sympathetic trigger and slow content), THEN slow-alpha and alpha-theta training to drop the arousal. Read the brain, and the trajectory of a whole life changes. Plus: Joshua Moore previews his first QEEG-phenotypes workshop.
Melissa and Lyndsay dedicate the entire episode to breaking down part three of the Summer House reunion. Melissa explains psychological concepts underlying Amanda and West's behaviors leading to a discussion about beta blockers, SSRI's and empathy. Melissa also discusses mature love vs. infatuation, emotional affairs, body language and more.THANK YOU FOR LISTENING and for all the support! Please follow Recap Rode and Your Bish Therapist podcast; please give a 5-star comment & rating (it really helps!)Please follow @vanderpodrecaps, @recaprodeo and @yourbishtherapist on Instagram, YouTube, Patreon, and FB.For full video (ad free, early release, full video & bonus content) visit YBT Patreon, Spreaker Supporters Club or YouTube Patreon (Ad Free, Early Release, Full Video, Bonus Content) https://patreon.com/YourBishTherapist?utm_medium=unknown&utm_source=join_link&utm_campaign=creatorshare_creator&utm_content=copyLinkApple Podcast (Ad Free): https://apple.co/3MfskzeSpreaker Supporters club (Ad Free, Early Release): https://www.spreaker.com/podcast/your-bish-therapist--6065109/supportYouTube (Full Video): https://www.youtube.com/channel/UCu8bmVPTlWANg5v7rGRJjow?subconfirmation=1 To find links to all YBT content: https://linktr.ee/yourbishtherapistBrand Ambassador: www.Iamhumanthebrand.com for clothing with a purpose. Code BISH20 for 20% off purchase Disclaimer: Posts are not intended to diagnose, treat or provide medical advice. Your Bish Therapist (YBT) is for entertainment and informational purposes only. The podcast, my opinions, and posts, are my own and are not associated with past or present employers, any organizations, Bravo TV, Grey Heart productions or any other television network. The information in YBT podcast and on its its social media is provided for general informational purposes only and is not intended to diagnose or treat. Please do not act or refrain from acting based on anything you read, see, or hear on YBT, podcast or associated social media. Communicating with YBT via email, and/or social media does not form a therapeutic alliance. Melissa, operator of YBT, is unable to provide any therapeutic advice, treatment or feedback.
Secretary of Health & Human Services Robert F. Kennedy, Jr. is, to put it mildly, a skeptic of selective serotonin reuptake inhibitor (SSRI) medication, a form of meds that millions of Americans use regularly with tremendous benefit. He was once on SSRIs, went off them, then became addicted to heroin, and he believes these events are linked. He also believes they cause school shootings and cause harm to developing fetuses. There is no evidence to support this. Andrea Salinas, a Democrat who represents the 6th district in Oregon in the House of Representatives, joins us to unpack Kennedy's latest efforts to curtail SSRI use and availability and what her minority party is doing to answer the threat. Then we're joined by journalist Jason Gale, author of the book After Covid: The Health Impacts That Will Last Generations, for an update on the long-term mental health effects of the pandemic's trauma and of long covid. Thank you to all our listeners who support the show as monthly members of Maximum Fun. Check out our I'm Glad You're Here and Depresh Mode merchandise at the brand new merch website MaxFunStore.com! Hey, remember, you're part of Depresh Mode and we want to hear what you want to hear about. What guests and issues would you like to have covered in a future episode? Write us at depreshmode@maximumfun.org. Depresh Mode is on BlueSky, Instagram, Substack, and you can join our Preshies Facebook group. Help is available right away. The National Suicide Prevention Lifeline: 988 or 1-800-273-8255, 1-800-273-TALK Crisis Text Line: Text HOME to 741741. International suicide hotline numbers available here: https://www.opencounseling.com/suicide-hotlines Help support this show and unlock bonus content! Become a member at https://maximumfun.org/joindepresh Help support this show and unlock bonus content! Become a member at https://maximumfun.org/joindepresh
Real Life Pharmacology - Pharmacology Education for Health Care Professionals
In this episode, we explore four unique antidepressants that do not fit neatly into the traditional SSRI or SNRI categories: trazodone, nefazodone, vilazodone, and vortioxetine. Trazodone and nefazodone are classified as serotonin antagonist and reuptake inhibitors (SARIs), working primarily through blockade of 5-HT2 receptors while also inhibiting serotonin reuptake. Trazodone’s strong antihistamine and alpha-1 blocking properties make it highly sedating and commonly used off-label for insomnia, whereas nefazodone causes less sedation but is rarely prescribed today because of its association with severe and potentially fatal liver toxicity. Both agents are notable for producing less sexual dysfunction than many traditional SSRIs. We also discuss two newer multimodal antidepressants: vilazodone (Viibryd) and vortioxetine (Trintellix). Vilazodone combines serotonin reuptake inhibition with partial agonism at the 5-HT1A receptor, a mechanism often compared to combining an SSRI with buspirone. Vortioxetine has an even more complex pharmacology, acting as a serotonin reuptake inhibitor while modulating multiple serotonin receptor subtypes through agonist, partial agonist, and antagonist actions. This multimodal activity may contribute to benefits in cognitive symptoms associated with major depressive disorder. Throughout the episode, we compare receptor pharmacology, clinical applications, adverse effect profiles, and the unique characteristics that distinguish these medications from more commonly prescribed antidepressants. Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE! Support The Podcast and Check Out These Amazing Resources! NAPLEX Study Materials BCPS Study Materials BCACP Study Materials BCGP Study Materials BCMTMS Study Materials Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated) Guide to Drug Food Interactions (Amazon Best Seller) Pharmacy Technician Study Guide by Meded101
What if the scariest thoughts in your head mean nothing at all? William Schultz spent ten years trapped inside obsessive compulsive disorder. It got so bad he became afraid of his own shadow, checking it every time he flipped a light switch. Then he made one brave decision that put him in remission within two months. No drugs. No endless analysis. Today he's a psychotherapist in St. Paul, president of OCD Twin Cities, and the expert who pushed the International OCD Foundation to revise its own treatment guidelines in 2025.In this conversation, Dr. Roger McFillin and William expose why standard mental health care makes OCD worse. They reveal what actually frees people in an in depth conversation. If you've ever been attacked by a thought you couldn't turn off, this episode is your way out.
Psychiatric medications have helped many people, but are they always the best solution?In this episode, Kelsi Sheren sits down with Dr. Josef to discuss the benefits, risks, and limitations of modern psychiatric treatment. Together they explore antidepressants, anxiety medications, long-term use, withdrawal challenges, informed consent, and why some patients feel their concerns are ignored.This conversation examines difficult questions surrounding mental health care, including whether medication is sometimes prescribed too quickly, what alternatives may exist, and how patients can make informed decisions about their treatment.Topics include:• The rise of psychiatric medication use• Potential risks and side effects• Dependence and withdrawal challenges• The role of therapy and lifestyle interventions• Informed consent in mental health care• When medication may help and when it may not• How patients can advocate for themselvesWhether you agree or disagree, this episode aims to encourage critical thinking and open discussion about one of the most important issues in modern health care.#MentalHealth #Psychiatry #Antidepressants #PsychiatricMedication #MentalHealthAwareness #KelsiSheren #Psychology #Healthcare #Depression #Anxiety- - - - - - - - - - -Buy me a coffee! - https://buymeacoffee.com/kelsisherenLet's connect!Rumble - https://rumble.com/user/TheKelsiSherenPerspectiveInstagram - https://www.instagram.com/thekelsisherenperspective?utm_source=ig_web_button_share_sheet&igsh=ZDNlZDc0MzIxNw%3D%3DX: https://x.com/KelsisherenSubstack: https://substack.com/@kelsisherenSUPPORT OUR PEOPLE - - - - - - - - - - - -MasterPeace - 10% off with code KELSI - https://www.MasterPeace.Health/KelsiKetone IQ- 30% off with code KELSI - https://ketone.com/KELSIGood Livin - 20% off with code KELSI - https://www.itsgoodlivin.com/?ref=KELSIBrass & Unity - 20% off with code UNITY - http://www.brassandunity.com
Stephanie Thaler has lived many lives in one. She survived thyroid cancer at 18, gained 60 pounds during radiation treatment while being isolated in a hospital with zero human contact, and came out the other side with a calling — massage therapy. What followed was 28 years of relentless learning, Guinness World Record-breaking fitness (715 burpees in 60 minutes), becoming the massage therapist for the Minnesota Vikings and the 2022 US Women's Olympic Hockey Team, founding the first barefoot massage school in Minnesota, and becoming the highest-paid manual therapist in her state through a technique called adhesion release methods — a specialized approach to releasing nerve entrapments that only 50 practitioners worldwide are certified in. In this conversation with Freddie, Stephanie breaks down what adhesions actually are, why nerve entrapment goes undetected on MRIs and gets dismissed by conventional medicine, how she's getting results in four to six sessions for people who have been in chronic pain for years, and what the difference is between radial and focused shockwave therapy when treating specific nerve pathways. The second half of this episode goes somewhere deeply personal. Stephanie shares that her father died by suicide on Thanksgiving when she was five years old — and that she spent the next 38 years living in a state of chronic fight or flight, cycling through every SSRI, CBT protocol, and alternative therapy available, never finding lasting relief. Until ketamine. In two weeks of six IV sessions, she healed more trauma than 18 years of cognitive behavioral therapy ever touched. Her father came to her in session. God held her. And she came out glowing. She now does at-home ketamine therapy three to five days a week and credits it with putting her depression into remission and fueling the most successful chapter of her career. This is an honest, science-grounded, spiritually rich conversation about healing the body and the nervous system from the inside out — and what becomes possible when you finally feel safe. Highlighted Moments [00:00] Understanding Collagen and Nerve Entrapment [01:56] The Science Behind Red Light Therapy [03:21] Supporting Immune Function with SilverBiotics [04:13] Personal Journey: From Cancer to Fitness [05:27] Training for a World Record in Burpees [06:49] The Impact of Cancer on Body and Mind [10:26] Tissue Mechanics and Emotional Trauma [13:17] Evolving Techniques in Bodywork and Therapy [16:25] Releasing Nerve Adhesions for Pain Relief [18:12] Chronic Nerve Entrapment and Treatment Duration [19:24] Cost and Value of Advanced Therapy Sessions [21:30] Practitioner Longevity and Body Care [23:01] Working with High-End Athletes [25:32] Biohacking Tools and Self-Care Routines [31:35] Focused Shockwave and Brand Technologies [35:17] Home Biohacking and Contrast Therapy [37:36] Future Vision: Wellness Barns and Community Spaces [41:33] Advice for Aspiring Practitioners [46:57] Being Beautifully Broken: Embracing Imperfection [48:00] Ketamine and Mental Health Transformation [50:54] The Power of Neural Rewiring and Support [53:31] The Role of Set and Setting in Therapy [56:27] Research and Future of Medical Psychedelics [57:17] Where to Find Stephanie and Resources Connect with Stephanie: https://stephaniethalerlmt.com Upgrade Your Health LightPathLED: https://lightpathled.pxf.io/c/3438432/2059835/25794 Code: beautifullybroken Silver Biotics Wound Healing Gel: https://bit.ly/3JnxyDD 30% off with Code: BEAUTIFULLYBROKEN Bimini: https://biminihydrotherapy.com/?rfsn=8883833.3df4c7 Code: beautifullyborken CONNECT WITH FREDDIEWork with Me: https://www.beautifullybroken.world/biological-blueprintWebsite and Store: (http://www.beautifullybroken.world) Instagram: (https://www.instagram.com/freddie.kimmelYouTube: https://www.youtube.com/@beautifullybrokenworld Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
In this special solo episode, adapted from a recent live training, Paul F. Austin explores one of the most important and often overlooked realities of microdosing: different substances create different outcomes. Find full show notes and links here: https://thethirdwave.co/podcast/episode-359/?ref=278 Drawing on more than a decade of experience in psychedelic education and coaching, Paul compares psilocybin, LSD, huachuma (San Pedro), ketamine, and iboga through the lens of client goals, nervous system regulation, emotional processing, cognitive performance, and contraindications. Paul explains why generic microdosing protocols often fall short, how practitioners can better match substances to individual needs, and why context, preparation, and integration matter far more than any single medicine. He also shares why huachuma has become the foundation of the Psychedelic Coaching Institute's microdosing methodology and offers guidance for practitioners looking to support clients with greater precision and care. Highlights: Why generic microdosing protocols can fall short How psilocybin supports emotional processing and inner work LSD's role in focus, creativity, and physiological performance Why huachuma may be especially useful for nervous system regulation Ketamine's role in SSRI tapering and clinical support Iboga's potential for neurodegenerative conditions and brain injury How to match substances to a client's goals and baseline state Why contraindications and clinical-grade intake matter How microdosing can support post-journey integration Why "more medicine" is not always the answer Episode Links: Paul on Instagram The Psychedelic Podcast The Psychedelic Coaching Institute Episode Sponsors: The Practitioner Certification Program by Third Wave's Psychedelic Coaching Institute. The Microdosing Practitioner Certification at Psychedelic Coaching Institute. Golden Rule - Get a lifetime discount of 10% with code THIRDWAVE at checkout Disclaimer: This content is for educational, informational, and entertainment purposes only. We do not promote or encourage the illegal use of any controlled substances. Nothing said here is medical or legal advice. Always consult a qualified medical or mental health professional before making decisions related to your health. The views expressed herein belong to the speaker alone, and do not reflect the views of any other person, company, or organization. Third Wave occasionally partners with or shares information about other people, companies, and/or providers. While we work hard to only share information about ethical and responsible third parties, we can't and don't control the behavior of, products and services offered by, or the statements made by people, companies, or providers other than Third Wave. Accordingly, we encourage you to research for yourself, and consult a medical, legal, or financial professional before making decisions in those areas. Third Wave isn't responsible for the statements, conduct, services, or products of third parties. If we share a coupon code, we may receive a commission from sales arising from customers who use our coupon code. No one is required to use our coupon codes.
Kent and this wife had a very open marriage but it all stoped once they both went on medication and he called in to talk all about it. Tune in to hear all the details including how and when they decided to open up their marriage and the first guy they met up with and what went down, when she started seeing the guy solo, his first heteroflexible experience and what went down and how he felt about it, the dp and dvp experiences his wife had, all the other things his wife got into including flogging, being blindfolded, being fisted and more, how being open changed their marriage and all the positives that came out of it, how and why they both wound up on SSRI medication and how it effected the both of them, how his wife wound up on even more meds over time and all the side effects she had, what his wife's can do to try and get off her meds, what his medications do to him and what he's been looking into to get off of his meds plus a whole lot more. GET A COPY OF THE STRICTLY ANONYMOUS BOOK! Strictly Anonymous Confessions: Secret Sex Lives of Total Strangers. A bunch of short, super sexy, TRUE stories. GET YOUR COPY HERE: https://amzn.to/4i7hBCd or Pre-order audiobook version here To see HOT pics of VERONICA plus my other female guests + hear anonymous confessions + get all the episodes early and AD FREE, join my Patreon! It's only $7 a month and you can cancel at any time. You can sign up here: https://www.patreon.com/StrictlyAnonymousPodcast and when you join, I'll throw in a complimentary link to my private Discord! To join SDC and get a FREE Trial! click here: https://www.sdc.com/?ref=37712 or go to SDC.com and use my code 37712 Want to be on the show? Email me at strictlyanonymouspodcast@gmail.com or go to http://www.strictlyanonymouspodcast.com and click on "Be on the Show." Want to confess while remaining anonymous? Call the CONFESSIONS hotline at 347-420-3579. All voices are changed. Sponsors: https://VB.Health - To get 10% off DRIVE BOOST by VB Health, use code: STRICTLY https://bluechew.com — Buy 2 months of Bluechew GOLD and get the third month FREE! Use code: STRICTLYANON http://bollandbranch.com/strictlyanon Use code STRICTLYANON for 20% off plus FREE shipping https://www.promescent.com/kathykay15 - New customers get 15% off entire order, automatically applied at checkout https://beduc.at/pd2618-anonymous Click here to take the quiz and get your personalized roadmap to sexual happiness https://RYTHM.HEALTH.com/STIRCTLYANON for 15% OFF your first month https://www.quince.com/strictlyanon — For premium quality Quince clothing plus FREE shipping and 365 day returns! Follow me! Instagram https://www.instagram.com/strictanonymous/ X https://twitter.com/strictanonymous?lang=en Website http://www.strictlyanonymouspodcast.com/ Everything else: https://linktr.ee/Strictlyanonymouspodcast Learn more about your ad choices. Visit megaphone.fm/adchoices
Mace and Jeff put Matt Walsh's antidepressant episode under the clinical microscope — and it does not pass the functional impairment test. They break down the 2022 Molecular Psychiatry umbrella review that dismantled the low-serotonin narrative, explain why that finding doesn't indict SSRIs as a category, and make the case that the “chemical imbalance” pitch was always more pharmaceutical advertising than clinical science. They also tackle what functional impairment actually means in diagnosis, the gender disparity in antidepressant prescribing, whether the SSRI-to-mass-violence argument is causal or just really committed to showing up in the same sentence, and what clinicians should actually be telling clients about medications they can't fully explain. For anyone who has ever explained serotonin to a client and quietly wondered if they knew what they were talking about: this one's for you. Music: “Machine Heart – Instrumental version” by Icarus. Licensed via Artlist Pro License #JeMO9k. Bielefeldt, A. Ø., Danborg, P. B., & Gøtzsche, P. C. (2016). Precursors to suicidality and violence on antidepressants: systematic review of trials in adult healthy volunteers. Journal of the Royal Society of Medicine, 109(10), 381–392. https://doi.org/10.1177/0141076816666805 Brody, D. J., & Gu, Q. (2020). Antidepressant use among adults: United States, 2015–2018. NCHS Data Brief, No. 377. https://www.cdc.gov/nchs/products/databriefs/db377.htm Chua, K. P., Volerman, A., Zhang, J., Hua, J., & Conti, R. M. (2024). Antidepressant dispensing to US adolescents and young adults: 2016–2022. Pediatrics, 153(3), e2023064245. https://doi.org/10.1542/peds.2023-064245 Healy, D., & Mangin, D. (2024). Post-SSRI sexual dysfunction: barriers to quantifying incidence and prevalence. Epidemiology and Psychiatric Sciences, 33, e44. https://doi.org/10.1017/S2045796024000441 Kuehner, C. (2017). Why is depression more common among women than among men? The Lancet Psychiatry, 4(2), 146–158. https://doi.org/10.1016/S2215-0366(16)30263-2 Moncrieff, J., Cooper, R. E., Stockmann, T., Amendola, S., Hengartner, M. P., & Horowitz, M. A. (2023). The serotonin theory of depression: a systematic umbrella review of the evidence. Molecular Psychiatry, 28, 3243–3256. https://doi.org/10.1038/s41380-022-01661-0 Salk, R. H., Hyde, J. S., & Abramson, L. Y. (2017). Gender differences in depression in representative national samples: Meta-analyses of diagnoses and symptoms. Psychological Bulletin, 143(8), 783–822. https://doi.org/10.1037/bul0000102 Stone, M., Laughren, T., Jones, M. L., Levenson, M., Holland, P. C., Hughes, A., Hammad, T. A., Temple, R., & Rochester, G. (2009). Risk of suicidality in clinical trials of antidepressants in adults: analysis of proprietary data submitted to US Food and Drug Administration. BMJ, 339, b2880. https://doi.org/10.1136/bmj.b2880
SSRI,全称 selective serotonin reuptake inhibitor,中文叫做选择性血清素再摄取抑制剂,是目前全球使用最广泛的抗抑郁药物。百忧解、左洛复、来士普,这些名字你可能不陌生。仅在美国,2023年就有约11.4%的成年人在服用抗抑郁药物处方。在全球抗抑郁药市场中,SSRI 占据了超过55%的份额,市场规模在2024年达到187亿美元,而且还在持续增长。这类药物之所以能走到今天的位置,背后有一个支撑它的理论——「血清素假说」,也就是抑郁症是因为大脑里的血清素不足。这个假说塑造了几十年来医生开药的逻辑,也塑造了无数患者对自己疾病的理解方式。但问题在于,这个理论从来没有在人体上被直接证明过。这期节目我们聊一聊,血清素假说从何而来,又有哪些证据动摇了它;如果血清素不是答案,科学界目前的新方向是什么;以及两类颠覆性的新药为什么值得关注。时间轴[01:48] 我...去小宇宙查看完整单集简介在小宇宙查看该单集文稿
這一集我們討論了肌酸的運作機制與效益,以及特定族群補充肌酸的建議。【補充說明】勁瑋:感謝博恩的邀請,我把這集提到的文獻放在這裡供觀眾參考,另外針對睡眠剝奪「逆轉」大腦損傷一詞,我的用詞過於武斷,研究是「減少」熬夜對大腦的損傷而非「逆轉」,特地於此勘誤,還請大家多包含。- Warrier et al. (2023)《運動健康》傘狀回顧:把 7 種運動表現補劑攤開比較,肌酸是唯一同時安全又有效的https://pubmed.ncbi.nlm.nih.gov/37688400/- Saab et al. (2002)《實驗生理學》MR 證實水分在肌肉細胞內,不是儲存於皮下https://pubmed.ncbi.nlm.nih.gov/12089606/- Spillane et al. (2009)《國際運動營養學期刊》肌酸乙酯 vs 一水肌酸直接比較https://pubmed.ncbi.nlm.nih.gov/19228401/- Ostojic & Ahmetovic (2008)《運動醫學研究》劑量與腸胃道不適https://pubmed.ncbi.nlm.nih.gov/18373286/- Gordji-Nejad et al. (2024)《科學報告》大腦代謝改變+認知改善https://pubmed.ncbi.nlm.nih.gov/38418482/- Bender et al. (2008)《神經生物學與老化》老鼠壽命+9%、腦部老化延緩https://pubmed.ncbi.nlm.nih.gov/17416441/- Lyoo et al. (2012)《美國精神醫學期刊》肌酸+SSRI,第 2 週就出現顯著改善https://pubmed.ncbi.nlm.nih.gov/22864465/- Smith-Ryan et al. (2021)《營養素》女性全生命週期,肌酸儲備天生低 70–80%https://pubmed.ncbi.nlm.nih.gov/33800439/- Burke & Schoenfeld (2023)《營養素》用 MRI/CT 影像確認真正的肌肥大https://pubmed.ncbi.nlm.nih.gov/37432300/本集節目由【 眠豆腐 】贊助播出﹋﹋﹋﹋﹋﹋﹋﹋﹋﹋﹋﹋﹋﹋﹋﹋﹋台灣設計製造的眠豆腐床墊
We love to hear from our listeners. Send us a message. On this week's episode of the Business of Biotech, Jeff Jonas, M.D., CEO of Tortugas Neuroscience, talks about the company's April 2026 launch and how in-licensed development assets were chosen. Jeff explains his strategy of chasing fast proof of safety and efficacy in humans, not animals, and talks about what product differentiation looks like in brain disorders, from adjusting indication targets to conducting head-to-head trials. He also reflects on the opportunity with psychedelics, RFK Jr.'s quest to curb SSRI prescriptions, the payer landscape in CNS disorders, and more. Access this and hundreds of episodes of the Business of Biotech videocast under the Business of Biotech tab at lifescienceleader.com. Subscribe to our monthly Business of Biotech newsletter. Get in touch with guest and topic suggestions: ben.comer@lifescienceleader.comFind Ben Comer on LinkedIn: https://www.linkedin.com/in/bencomer/
Spouting Off with Karen Kataline Immigration, Western Civilization, Psychiatric Drugs, and Green Energy Karen Kataline Continues the Alan Nathan Show in Alan's Memory In this episode of The Alan Nathan Show / Alan Nathan All-Stars, host Karen Kataline opens by acknowledging the untimely passing of Alan Nathan and explaining that the show continues in his memory and honor. She notes that she and Alan had often done Mondays together and says it is an honor to help continue the program during this transitional period for the Main Street Radio Network. Throughout the episode, Karen frames the broadcast as part of a new chapter while preserving the spirit, name, and tradition of the Alan Nathan All-Stars. Immigration, Libertarianism, and Sanctuary Policies Karen's first guest is the executive director of the Center for Immigration Studies, identified in the transcript as Mark Krikorian or a similar spelling. They discuss immigration enforcement, libertarian arguments for open immigration, and the tension between open borders and a welfare state. Mark argues that libertarians once aligned more closely with conservatives on taxes, regulation, and the size of government, but now often align with the left on questions of sovereignty, borders, and immigration. He cites Milton Friedman's argument that open immigration and a welfare state cannot coexist and says that while social programs can be tightened, the welfare state is not simply going away. Chicago, ICE, and Local Non-Cooperation The discussion then turns to Chicago, Cook County, and Illinois, which Mark describes as sanctuary jurisdictions. He explains that ICE is not asking local police to conduct immigration checks in the street, but to hold criminal suspects who are already arrested and fingerprinted if they are deportable, so ICE can take custody. He argues that sanctuary policies release deportable offenders back into communities and says this especially harms immigrant neighborhoods. Karen and Mark also criticize Chicago Mayor Brandon Johnson and Illinois Governor J.B. Pritzker, accusing them of interfering with immigration enforcement and downplaying violence in Chicago. Karen Reflects on Alan Nathan and the Show's Transition After the first interview and intervening ad segments, Karen returns to discuss the show's transition after Alan Nathan's death. She encourages listeners to hear the tribute program that aired over the weekend and recalls clips of Alan and his wife Jane from years earlier, describing their on-air chemistry as entertaining, lively, argumentative, and classic talk radio. Karen says it is a sad time for everyone at Main Street Radio Network, but emphasizes that the Alan Nathan Show and Alan Nathan All-Stars tradition will continue. James Hankins on The Golden Thread and Western Civilization Karen then welcomes James Hankins, described as a Harvard University historian and co-author of The Golden Thread: A History of the Western Tradition. Hankins explains that the “golden thread” is a metaphor for the Western tradition, and that the book aims to recover the history of Western civilization from the ancient Greeks and Romans through the Middle Ages and into the modern world. He argues that this history has not been properly taught in schools or universities for decades, leaving people without a shared understanding of democracy, republics, communism, socialism, and the meaning of Western civic life. Communism, Democratic Socialism, and Historical Amnesia Karen connects the discussion to contemporary politics, warning against Marxism, communism, and democratic socialism. Hankins says many people who call themselves democratic socialists do not understand what the term means or how socialism has operated historically. He argues that adding the word “democratic” does not solve the deeper problem, because socialism has not historically favored democracy. Karen and Hankins agree that many public arguments suffer because people no longer share basic definitions or historical knowledge, especially about the distinction between a republic and a democracy. Dr. Toby Watson on Psychiatric Drugs and Violence Later, Karen interviews clinical psychologist Dr. Toby Watson, who says he has worked on research and testimony related to psychiatric medications, including SSRI antidepressants and black-box warning labels. Watson says his work involves outcome research on psychotropic medications and forensic cases where people with no history of violence commit violent or self-destructive acts after taking medication. Karen asks whether antidepressants and psychiatric medications may be contributing to violence, especially in the wake of Columbine-era discussions. Watson answers strongly that SSRIs can increase suicidal thoughts and behavior and says this is acknowledged in FDA black-box warnings. Akathisia, Political Motives, and Youth Medication Dr. Watson discusses akathisia, describing it as an inner agitation or restlessness that can make people feel as though they want to crawl out of their skin. He says it can occur with SSRIs and is even more common with antipsychotics. Karen asks whether suppression of this information may be about more than money, suggesting possible political motives. Watson agrees that politics can be involved and argues that children in poverty, especially those connected to Medicaid or Medicare systems, are disproportionately medicated at higher doses even when diagnosis and symptom severity are considered. He also references Anatomy of an Epidemic and argues that long-term psychiatric drug use can contribute to disability and general decline. Gender Ideology, Violence Profiles, and Dr. Watson's Cautions Karen and Watson also discuss social contagion, gender ideology, and political violence. Karen asks about the murder of Charlie Kirk and whether the alleged killer was on psychiatric medication. Watson says he has no direct knowledge and is not involved in that investigation, cautioning that too much misinformation is circulating to make a firm claim. However, he says the suspect fits a known profile for certain kinds of shooters and that, statistically, it would not surprise him if psychiatric medication were involved. Karen closes the short segment by inviting Watson back and directing listeners to his work online. Steve Goreham / Gorham on Green Energy and Rising Electricity Prices Karen closes the show with Steve Goreham or Steve Gorham, described as executive director of the Climate Science Coalition of America and author of Green Breakdown: The Coming Renewable Energy Failure. The conversation focuses on rising electricity prices, renewable energy policies, and what Karen calls the “green new scam.” Steve argues that expensive electricity increases are concentrated in blue states that have pursued aggressive green policies, naming California, Maine, New York, Maryland, Massachusetts, and Connecticut. He contrasts those with states such as Georgia, Florida, Texas, and Missouri, which he says rely more on natural gas or coal and have seen smaller increases. AI, Data Centers, Pipelines, and Energy Reality Steve argues that green-energy policies are running into the reality of rising electricity demand, especially from artificial intelligence and data centers built by companies such as Meta, Microsoft, and Amazon. He says AI-related electricity demand requires constant 24-hour power and cannot be reliably supported by wind and solar alone. Karen and Steve also discuss the Keystone pipeline, New York pipeline politics, natural gas constraints in New England, offshore wind leverage, and the role of Trump administration energy policy. Steve closes by directing listeners to his book Green Breakdown and website. Closing the New Chapter of the Alan Nathan All-Stars Karen ends the show by saying the Alan Nathan All-Stars are heading into a new chapter, but with Alan Nathan still serving as the program's guiding star. The episode as a whole blends remembrance of Alan with Karen's political and cultural commentary, moving through immigration enforcement, Western civilization, psychiatric drugs, gender ideology, energy policy, and the future of American public debate.
Delilah, one of the most iconic voices in American radio, sits down with Bunnie Xo for a raw, emotional, and surprisingly funny deep dive into the life behind her legendary late-night show. With 8–10 million weekly listeners, she's been the comforting voice in America's bedrooms for decades—but here she opens up in a way you rarely hear.In this episode, Delilah talks about growing up with a high-functioning alcoholic father and a codependent mother, discovering secret half-siblings just miles away, and even being duct-taped by a teacher for talking too much—only to turn that “problem” into a superpower and a record-breaking radio career. She shares the harsh sexism and harassment she faced in radio, the mentor who helped her transform a throwaway nighttime shift into a national brand, and the night she hit rock bottom, asked God to prove He was real, and began a completely new chapter of faith.Delilah also takes us inside her life as a mom to a huge blended family through birth, foster care, and international adoption, and she doesn't shy away from the dark realities of the foster system or the trauma so many kids carry. She opens up about losing her son Sammy to sickle cell complications and her son Zach to suicide after SSRI side effects, and how she still chooses love, service, and God in the middle of unthinkable grief. From farm-to-table living, gardening and cows, to a house full of kids and multiple girls named Delilah, this conversation is as real and layered as it gets.Delilah: Website | TikTok | FB | IGWatch Full Episodes & More: YouTubeSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
About six million Canadians fill prescriptions for antidepressants. And now, SSRI's are coming under increasing scrutiny with a push to curb psychiatric drugs in the United States.. We discuss the latest, evidence-based research on depression about what we know - and don't know - about its causes, and whether the drugs prescribed to treat it are still the best option.
Went to your doctor in your early 40s with sudden anxiety, insomnia, brain fog or unexplained weight gain — and walked out with an antidepressant? Author and nurse practitioner Dani Williamson joins Dr. Chris Motley to explain why SSRIs are not the answer to perimenopause, what's actually happening in your body as estrogen drops, and how healing your gut can bring your thyroid and hormones back into balance. Key Takeaways from this Conversation: Women are being prescribed SSRIs for anxiety when the real cause is perimenopause. There's no SSRI for that. Estrogen-loss comes with mood symptoms, weight gain and health concerns like Hashimoto's Thyroiditis as your thyroid begins to slow down. Fix your gut and your thyroid and hormones will (usually!) fall into place. Dani Williamson's Top 7 Most Inflammatory Food: Gluten Dairy Soy Corn Sugar Eggs Peanuts If your doctor's reaction to a health concern brought on by estrogen-loss is “let's just watch this for 6 months,” it's time to find a new doctor. A tiny low-dose estrogen patch can change your perimenopause game. Healing trauma and abuse is key (especially when it comes to thyroid health): Unaddressed childhood trauma can collide with the body-chaos of perimenopause. EMDR and talk therapy can help with this journey. ------ Follow Doctor Motley! Instagram TikTok Facebook Website Connect with Dani Williamson (she's taking new Hashimoto's patients) https://www.instagram.com/daniwilliamsonwellness/ https://daniwilliamson.com/ Buy Dani's book: https://shorturl.at/28pv3 Dani and Dr. Motley's Sunday Night Service: Your health questions answered: Dani Williamson and Dr. Motley ------ * You can get cell support in gummy form: Mitopure now starts at $79, when you go to timeline.com/DRMOTLEY. *Join Doctor Motley's newsletter for TCM insights and regular podcast updates: https://www.doctormotley.com/ *Do you have a ton more in-depth questions for Doctor Motley? Check out his course on emotions and the body in his membership. You'll find other courses full of his expertise and clinical wisdom, plus bring all your questions to his weekly lives! To try risk-free for 15 days click here: https://www.doctormotley.com/15
Hour 2 for 5/18/26 Drew and Brooke pray the Chaplet of Divine Mercy (1:00). Then, Josef Witt-Doerring, MD joins Drew to discuss SSRI withdrawal (28:06). Topics: why these drugs are prescribed so often (31:21), side effects (37:39), dealing with depression (41:24), overdosing (46:36), and OCD (48:34). Link: taperclinic.com https://www.youtube.com/@taperclinic
In this episode, we explore how to manage SSRI treatment in pregnant patients — addressing common fears around fetal malformations, medication switching, and neonatal withdrawal. Can stopping an antidepressant actually do more harm than continuing it? Faculty: Amanda Koire, M.D. Host: Richard Seeber, M.D. Learn more about our memberships here Earn 0.5 CME: Prescribing in Pregnancy: What Every Clinician Should Know SSRI Treatment During Pregnancy: A Clinical Case
You guys sent in some amazing questions for this Fan Mail Friday with Drs. Mark and Michelle Sherwood. We talked about everything from hormones, eczema, endometriosis, and peptides to gut health, sciatica, anxiety, and the growing concern over long-term SSRI use.This episode is really about getting to the root cause instead of just masking symptoms. If you've been struggling to find answers, feeling dismissed, or wondering if there's a better path forward for your health, I think this conversation is going to encourage you.Shop MyFreedomCart for trusted, American-made products that support your values.http://myfreedomcart.com/heidiShow mentions: http://heidistjohn.com/mentionsWebsite | http://heidistjohn.comSupport the show! | http://donorbox.org/donation-827Rumble | rumble.com/user/HeidiStJohnYoutube | / @heidistjohnpodcast Instagram | @heidistjohnFacebook | Heidi St. JohnX | @heidistjohnFaith That Speaks Online CommunitySubmit your questions for Fan Mail Friday | http://heidistjohn.com/fanmailfriday
Real Life Pharmacology - Pharmacology Education for Health Care Professionals
SSRI adverse effects are critical to know. In part 2 of this 2-part series on SSRIs, we cover the most important adverse effects to know, in addition to putting a nice bow on the most important clinical practice pearls on each SSRI. Enjoy the show! Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE! Support The Podcast and Check Out These Amazing Resources! NAPLEX Study Materials BCPS Study Materials BCACP Study Materials BCGP Study Materials BCMTMS Study Materials Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated) Guide to Drug Food Interactions (Amazon Best Seller) Pharmacy Technician Study Guide by Meded101
Feel Better. Live Free. | Health & Wellness Creating FREEDOM for Busy Women Over 40
Episode SummaryWomen have up to 70-80% lower creatine stores than men — and most of us have never been told that. In this episode Lisa digs into what that means for your brain, sleep, mood, muscles, and energy, and why creatine may be one of the most underreported tools in women's health right now.What You'll LearnWhat creatine actually is and why it matters beyond the gymWhy women have lower creatine stores — and why that gap widens in perimenopauseHow creatine supports brain energy (ATP) and what happens when levels run lowThe research on creatine and memory, processing speed, and mental clarityWhy creatine may reduce depression symptoms — more so in women than menCreatine and sleep: the adenosine mechanism, the 2024 women's RCT, and the 2025 perimenopause findingsThe University of Kansas Alzheimer's pilot studyCreatine + resistance training for muscle and bone health over 40How much to take: 5g for general health vs. 10g for brain-specific benefitsStart HereReady to heal your metabolism? thinlicious.com/happyStudies ReferencedCognitive Function & MemoryXu et al. (2024) — Creatine & Cognitive Function: Systematic Review & Meta-Analysis. Frontiers in Nutrition.Depression in WomenLyoo et al. (2012) — Creatine Augmentation for SSRI in Women With Major Depression. American Journal of Psychiatry.Systematic Review & Meta-Analysis: Creatine for Depression (2025). British Journal of Nutrition.SleepDworak et al. (2017) — Creatine Reduces Sleep Need & Homeostatic Sleep Pressure in Rats. Journal of Sleep Research.Aguiar Bonfim Cruz et al. (2024) — Creatine Improves Sleep in Naturally Menstruating Females. Nutrients.Gordji-Nejad et al. (2024) — Single Dose Creatine Improves Cognition During Sleep Deprivation. Scientific Reports.Hall et al. (2025) — Creatine + Resistance Training in Peri/Postmenopausal Women: Sleep, Cognition, Strength. JISSN.Alzheimer's DiseaseSmith et al. (2025) — Creatine Monohydrate Pilot in Alzheimer's: Brain Creatine & Cognition. Alzheimer's & Dementia.Brain Dosing: The Case for 10gDechent et al. (1999) — Creatine Increases Brain Creatine by 8.7% in Human Neuroimaging Study. American Journal of Physiology.Candow et al. — Higher Creatine Doses for Brain Bioenergetics. Journal of Psychiatry and Brain Science.Dr. Rhonda Patrick on 10g brain dosing (@foundmyfitness)Medical Disclaimer: For educational purposes only. Not medical advice. Always consult your doctor before starting any new supplement.
THIS WEEK ON REWIND: THIS WEEK ON REWIND: IS ANYONE HUNGRY!?!?!? GOOD, CAUSE WE HAVE A ROAST ON OUR HANDS!!! We've got some stories to tell and time to spare. First, we've gotta talk about the Hantavirus and everyone on. That. BOAT!! I'm sorry, sweetie…you're GONNA STAY there. Then we talk about James Charles opening his mouth again. Next, did y'all hear about that professor who got booed for supporting AI?? We did, and we gotta talk about it. Then, we gotta talk about what triggered Raven on the most recent episode of Summer House. Then, gathering your friends (& the tissues!!) because we are seeing “THE SHEEP DETECTIVES”, the cutest little movie that's feel like a hug from the 90's. Finally, we talk all about the INS & OUTS of Kevin Hart's ROAST on Netflix, what we loved and what we didn't love. It's all here, even though our brains kinda weren't, ON REWIND!! ⏰TIME CODES⏰ (0:10) RAVEN & THE HOMOPHOBIC FAN [FIRST THOUGHTS] (3:01) NOT THE HANTAVIRUS (6:26) RFK JR. & THE SSRI'S (10:11) JAMES CHARLES IS IN ANOTHER SCANDAL (16:41) CAITLIN CLARK, MORGAN WALLEN, & THE OPTICS OF THE WNBA (25:05) THE PROFESSOR WHO CRIED AI (28:43) REWIND RUNDOWN: SUMMER HOUSE [AMANDA'S MANIPULATIONS] (33:50) WAS THERE REWIND DRAMA IN ITALY?? (35:41) REWIND RUNDOWN: SUMMER HOUSE PT. 2 [CIARA'S RISE FROM THE ASHES] (44:35) REWIND RUNDOWN: THE SHEEP DETECTIVES (48:28) REWIND RUNDOWN: THE ROAST OF KEVIN HART (01:15:34) FINAL THOUGHTS Follow Blake: @heyblakerackley Follow Raven: @iamravendawson Follow Producer Gabe: @theproducergabe BUY REWIND MERCH (AVAILABLE NOW): https://rewindthepod.threadless.com SUBSCRIBE TO BLAKE'S YOUTUBE CHANNEL: https://www.youtube.com/@heyblakerackley WATCH RAVEN on THE TERRELL SHOW: https://youtu.be/7c0Y-DN-_A4?si=TlI0ZZpSKdDBmtNH COME SEE BLAKE @ RANCH HANDS COWBOYLESQUE: https://www.ranchhandscowboylesque.com [CODE: REWIND10] BOOK GABE WITH “HEY BACH!” EVENTS: https://www.heybachnash.com [CODE: REWIND] To watch the podcast on YouTube: https://www.youtube.com/playlist?list=PLVVnhe6Es3kFxV18W2oLrur6m3c7Lwl6- Follow Blake- Instagram: @heyblakerackley TikTok: @heyblakerackley Threads: @heyblakerackley Twitter: @heyblakerackley Follow Raven- Instagram: @iamravendawson TikTok: @iamravendawson Threads: @iamravendawson Follow Producer Gabe- Instagram: @_thenerdalert TikTok: @_thenerdalert ABOUT REWIND: The Podcast - Hosted by the effortlessly charismatic duo Raven Dawson and Blake Rackley, REWIND: The Podcast is where pop culture past meets pop culture present—with a whole lot of personality in between. Fueled by a love for iconic throwbacks and today's most talked-about moments, these two besties serve up unfiltered opinions, sharp humor, and a deep appreciation for the drama that keeps entertainment interesting. From Y2K nostalgia to red carpet chaos, award show upsets to reality TV scandals, nothing is off-limits. Whether they're revisiting the cultural staples that defined an era or breaking down the latest internet-breaking headlines, expect hot takes, deep dives, and plenty of side-eye. If your playlist lives somewhere between classic R&B and current chart-toppers, if you still quote your favorite 2000s movies on the daily, and if you love a little (or a lot of) flair with your pop culture commentary—this is the podcast you've been waiting for. Press play, lean in, and get ready to REWIND.
At the top of the episode YBT makes an exciting announcement about the podcast. Melissa and Kristen discuss RFK's recent assault on SSRI's, discussing postpartum mental health, medication and suicidal ideation (TW).Melissa and Kristen discuss more postpartum MH issues in The Valley; outlining how Kristen and Nia deserve better than what they are getting. Melissa breaks down king baby behaviors, Mia's trauma responses and mental health.Melissa shares an intriguing pattern noticed on Summer House, leading to a SH reddit thread featuring YBT and the gaining traction online. Melissa discusses triangulation, manipulation and duper's delight.THANK YOU FOR LISTENING and for all the support!Please follow YBT podcast and give a 5-star comment & rating (it really helps!)Please follow @drivingmomcrazy and @yourbishtherapist on Instagram, FB, Patreon, and YouTube For full video (ad free, bonus content & early releases) visit YBT Patreon, Spreaker Supporters Club or YouTubePatreon: https://patreon.com/YourBishTherapist?utm_medium=unknown&utm_source=join_link&utm_campaign=creatorshare_creator&utm_content=copyLinkAPPLE PODCAST https://apple.co/3MfskzeSpreaker Supporters club: https://www.spreaker.com/podcast/your-bish-therapist--6065109/supportYouTube: https://www.youtube.com/channel/UCu8bmVPTlWANg5v7rGRJjow?subconfirmation=1 To find links to all YBT content: https://linktr.ee/yourbishtherapistDisclaimer: Posts are not intended to diagnose, treat or provide medical advice. Your Bish Therapist (YBT) is for entertainment and informational purposes only. The podcast, my opinions, and posts, are my own and are not associated with past or present employers, any organizations, Bravo TV, Grey Heart productions or any other television network. The information in YBT podcast and on its its social media is provided for general informational purposes only and is not intended to diagnose or treat. Please do not act or refrain from acting based on anything you read, see, or hear on YBT, podcast or associated social media. Communicating with YBT via email, and/or social media does not form a therapeutic alliance. Melissa, operator of YBT, is unable to provide any therapeutic advice, treatment or feedback.
"Jack Riccardi talks Boston highway shooting, blue cities woes are chosen, why gym parking lot is dangerous, midterms, GenZers on SSRI drugs and trumps endorsement for TX senate runoff."
Today's Headlines: Trump kicked off the week rejecting Iran's latest peace proposal with "I don't like it — totally unacceptable," while a confidential Economist document reveals Russia offered Iran 5,000 advanced drones and training for 10,000 soldiers to use them against American troops. Iran's new supreme leader Mojtaba Khamenei hasn't been seen publicly since being severely injured in the airstrike that killed most of his family, complicating Iran's ability to negotiate. Someone also unveiled a 22-foot golden Trump statue at a Florida golf course, which his evangelical adviser insists is definitely not idol worship. In the redistricting wars, Virginia's Supreme Court struck down the congressional map that Virginia voters just voted for — the same court that previously cleared it — handing Republicans a significant midterm advantage before the south has even finished gerrymandering. Trump announced an "election integrity army" in every state this November, the FBI opened a new investigation into Wisconsin's 2020 election results, and the DOJ subpoenaed Fulton County for the names of every 2020 election worker, which Fulton County is fighting in court. To distract from all of this, the Pentagon started releasing UFO files, which is a thing that is happening. In brain worm updates, RFK Jr. is reportedly exploring banning certain SSRIs including Zoloft, Prozac, and Lexapro — his department denied it, though he just announced initiatives to reduce SSRI prescriptions. The Trump administration is also planning to cut Social Security disability benefits for people living with family members by up to a third, potentially affecting 400,000 people — call your congresspeople. Trump Media posted a $405 million loss on just $900,000 in revenue, 600,000 MAGA fans who paid a nonrefundable deposit for the Trump Phone in 2025 still don't have their devices and are finally revolting, and the Hantavirus cruise passengers are being carefully evacuated home from the Canary Islands with isolation protocols in place. And finally, Rudy Giuliani — who was read his last rites last week — is attempting to get his hospital bills covered by a federal fund for 9/11 first responders, which is one way to handle bankruptcy. Resources/Articles mentioned: Newsweek: Pastor defends Golden Trump statue from biblical backlash WSJ: Trump Blasts Iran's Response on Reopening Hormuz, Handling Uranium The Economist: Secret document reveals Russia's plans to aid Iran NYT: Virginia Court Strikes Down Redistricted Voting Map in a Huge Blow to Democrats Advance Local: Trump: GOP will have ‘election integrity army' in every state during 2026 midterms Wausau Pilot & Review: FBI is investigating Wisconsin's 2020 election, sources confirm - PBS: Justice Department seeks the names of 2020 election workers in Georgia's Fulton County NBC News: Pentagon releases declassified UFO files including videos and photos held by the government for decades Politico: Wiles cracks down on leaks CNBC: U.S. payrolls jump more than expected, but the report had several red flags for the economy The Daily Beast: MAGA Fans Revolt Over Trump Phone Disaster Bloomberg: Trump Media Posts $405 Million Loss Driven by Crypto Holdings CNN: Live updates: Hantavirus outbreak, passengers disembark cruise ship in Tenerife Reuters: Exclusive: Kennedy's health officials explored US ban of some widely used antidepressants ProPublica: The Trump Administration Aims to Penalize Disabled Adults Who Live With Their Families The Daily Beast: Rudy Giuliani Wants 9/11 Health Fund to Cover His Medical Bills Subscribe to the Betches News Room and join the Morning Announcements group chat. Go to: betchesnews.substack.com Morning Announcements is produced by Sami Sage and edited by Grace Hernandez-Johnson Learn more about your ad choices. Visit megaphone.fm/adchoices
RIP Midnight, a weekend getaway, wild birthday parties and permanent effects of SSRI's. Scotch tape is more useful than we thought, watch your mouth, bring back quick executions and we might be running out of gas. For weekly bonus episodes, HD chat, early releases and live streams join us on Patreon!Patreon.com/hellodysfunction Subscribe and watch on YouTube!https://youtube.com/@hellodysfunctionFollow us on IG: Instagram.com/hellodysfunction Submit your questions/stories: hellodysfunctionpodcast.com
A generation prescribed antidepressants by a vulture-like media/pharma complex starts to awaken. Did we really need these medications? What did they do to us? Kamala Harris' step daughter Ella Emhoff records her own awakening. Peter Doocy digs into the first drop of UFO Files and tells us what we think we see... and what we know we don't. The father of modern rocketry, Werhner von Braun, warned his closest associate 50 years ago that the deep state would play a final card - ALIENS - to normalize a space weapon program built on a lie.
RFK Jr.'s push to reduce antidepressant dependence is drawing fire from MSNBC and Reuters, and Jordan and Nate break down why. With 1 in 6 American adults on SSRIs and the global market generating $20 billion per year, the push for deprescribing pathways backed by a new CMS billing code is a genuine disruption to pharma revenue. RFK shares a personal account of a family member's SSRI withdrawal he describes as harder than heroin detox. The show then dismantles the hantavirus media cycle: 5 cases on a cruise ship, Moderna already codeveloping a vaccine, and Robert Malone reminding everyone that a lightning strike is statistically more likely. FDA Commissioner Makary's admission that the FDA deliberately misled the public on dietary fat for nearly two decades gets its moment, followed by a DOJ investigation into the Big Four meatpackers for antitrust violations and foreign ownership concerns. The episode closes with a discussion on statin overuse, CoQ10 depletion, thyroid health, iodine sources, and the structural problem of corporate consolidation across farming and food supply chains.
Real Life Pharmacology - Pharmacology Education for Health Care Professionals
In this episode, we break down the pharmacology of selective serotonin reuptake inhibitors (SSRIs) with a focus on the high-yield clinical pearls pharmacists, medical students, and healthcare professionals need to know. We compare the major SSRIs—including fluoxetine, sertraline, paroxetine, citalopram, escitalopram, and fluvoxamine—based on adverse effects, drug interactions, pharmacokinetics, and board exam relevance. Topics include serotonin syndrome, discontinuation syndrome, CYP450 interactions, QT prolongation, sexual dysfunction, weight changes, and SSRI selection in special populations such as older adults and pregnancy. Whether you are preparing for exams, clinical rotations, or looking to sharpen your psychopharmacology knowledge, this episode provides practical and memorable insights into one of the most commonly prescribed medication classes. This is Part 1 of 2. Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE! Support The Podcast and Check Out These Amazing Resources! NAPLEX Study Materials BCPS Study Materials BCACP Study Materials BCGP Study Materials BCMTMS Study Materials Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated) Guide to Drug Food Interactions (Amazon Best Seller) Pharmacy Technician Study Guide by Meded101
Grief doesn't care about your timeline and it definitely doesn't care about what other people think you “should” be sad about. I'm sharing the truth of grieving my dog Benjamin, including how the pain knocked me into a depression, how shame kept me quiet, and why losing a pet can feel like the biggest loss of your life.We get into the messy reality of anticipatory grief too: the slow decline, the constant vet visits, the bargaining that sounds like “if I do everything right, this won't happen,” and the way perfectionism turns tragedy into self-blame. I also talk about one of my biggest roadblocks, intellectualizing. When you're highly analytical or have interoceptive difficulties, it's easy to understand grief without actually feeling it, and that gap can keep you stuck for years.From there, we zoom out to the cultural problem. Western grief support often looks like discomfort, time limits, and toxic positivity. Phrases like “they're in a better place,” “you can get another one,” or “everything happens for a reason” might be meant as comfort, but they can steal someone's pain. What helps more is holding space, letting sadness exist, and allowing mourning to be real.I share practical tools that helped me start integrating grief: treating grieving like a practice, learning how to “anger” safely (scream into a pillow, write the letter you never send), making room for crying and sadness even when an SSRI blunts tears, and acknowledging small everyday losses so you're not blindsided by the big ones. If this connects with you, subscribe, share it with a friend who needs permission to feel, and leave a review so more people can find it. Where to find me: Connect with me on Instagram Check out my website Sign up for a free consult
Over 30 million Americans have been told a 19 billion dollar lie. Find out what doctors don't tell you about SSRI side effects, antidepressant effectiveness, and antidepressant risks that affect more people than you think. 0:00 Introduction: The 19 billion dollar lie1:12 Irving Kirsch and medical research bias2:09 Hamilton Depression Scale 2:59 Placebo vs. drug study for antidepressant effectiveness4:16 Antidepressant side effects4:33 Post-SSRI sexual dysfunction and emotional blunting5:49 Antidepressants and the placebo effect explained7:38 Natural antidepressants Download Dr. Berg's Free Daily Health Routine: https://drbrg.co/45qtO07Antidepressant effectiveness may be overstated. Irving Kirsch examined clinical trials on antidepressants and found that around 78% of them were unpublished, rewritten, or contained inflated results.The “gold standard” for measuring depression is the Hamilton Depression Rating Scale (HAM-D), which relies on subjective reporting and was not originally created to diagnose depression.In placebo-controlled trials, antidepressants did not significantly improve depression more than a sugar pill. A good night's sleep can improve the symptoms of depression significantly more than medication. Antidepressants come with a black box warning and many other side effects, including the following:• Sexual dysfunction • Post-SSRI sexual dysfunction • Emotional blunting• Discontinuation syndrome• Insomnia• Nausea• Anxiety• DepressionExercise, St. John's wort, omega-3s, and adequate sleep can help improve the symptoms of depression naturally. Dr. Eric Berg DC Bio:Dr. Berg, age 61, is a chiropractor who specializes in Healthy Ketosis & Intermittent Fasting. He is the Director of Dr. Berg Nutritionals and author of the best-selling book The Healthy Keto Plan. He no longer practices, but focuses on health education through social media.Disclaimer: Dr. Eric Berg received his Doctor of Chiropractic degree from Palmer College of Chiropractic in 1988. His use of “doctor” or “Dr.” in relation to himself solely refers to that degree. Dr. Berg is a licensed chiropractor in Virginia, California, and Louisiana, but he no longer practices chiropractic in any state and does not see patients, so he can focus on educating people as a full-time activity, yet he maintains an active license. This video is for general informational purposes only. It should not be used to self-diagnose, and it is not a substitute for a medical exam, cure, treatment, diagnosis, prescription, or recommendation. It does not create a doctor-patient relationship between Dr. Berg and you. You should not make any change in your health regimen or diet before first consulting a physician and obtaining a medical exam, diagnosis, and recommendation. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition.
There is some idea now that any woman with a loving husband wants sex. This could not be less true. Women may not want sex for all kinds of reasons that have zero to do with their husbands. They may be tired or stressed NO MATTER HOW MUCH HE DOES IN THE HOUSE (including 100% of the chores which I've seen many times), they may just have lower drives (remember there's a normal distribution of most every trait), they may have depression or anxiety, they may be older and at a changed hormonal stage, they may have a trauma history, they may be on medications that impact drive like SSRI's (or GLP-1 blockers as new research shows), they may have a condition with fatigue as a symptom like anemia or of course chronic fatigue. In fact, it's ANTI FEMINIST to say that a woman's drive would be solely due to a man, as women are not a purely reactive monolith. They are individuals with their OWN ISSUES AND PREFERENCES!My newest venture, including ALL BRAND NEW POSTS EVERY DAY: https://buymeacoffee.com/drpsychmom/postsJoin my awesome Midlife Women's Group here: drpsychmom.com/mwgTo get over 200 more episodes, most recently "You Don't Have To Attend Every Argument You're Invited To," subscribe here! https://creators.spotify.com/pod/show/drpsychmomshow/subscribe For my secret Facebook group, the "best money I've ever spent" according to numerous members: https://www.facebook.com/groups/drpsychmomFor coaching from DPM, visit https://www.drpsychmom.com/coaching/For therapy or coaching, contact us at https://www.bestlifebehavioralhealth.com/