Podcasts about MDMA

In this episode of The Psychedelic Podcast, Paul F. Austin speaks with psychiatrist and TaperClinic founder Dr. Josef Witt-Doerring about antidepressant withdrawal, psychiatric deprescribing, and psychedelic readiness. Find full show notes and links here: https://thethirdwave.co/podcast/episode-371/?ref=278 Josef explains what he learned reviewing drug safety at the FDA, why withdrawal can be mistaken for relapse, and how tapering often becomes more difficult at lower doses. They also explore the lifestyle foundations of mental health, benzodiazepine withdrawal, and why psychedelic clinics may need far more sophisticated support as increasingly medicated patients seek psilocybin, MDMA, LSD, and ketamine. Dr. Josef Witt-Doerring, MD, is a psychiatrist renowned for his expertise in drug tapering and withdrawal management. With years of experience in clinical psychiatry, he has developed a particular interest and specialization in assisting patients with the safe and effective tapering of psychiatric medications. His approach is patient-centered, focusing on individualized plans that prioritize patient well-being and functioning. He is the founder and medical director of TaperClinic. Highlights: What antidepressant research leaves unanswered Why withdrawal can resemble relapse How lower doses change tapering Five foundations before optimization hacks Benzodiazepines in psychiatric deprescribing Psychedelics versus conventional drug models Insurance pressure on psychedelic clinics Preparing for heavily medicated patients TaperClinic: https://taperclinic.com/ TaperClinic Free Guide: https://taperclinic.com/free-guide/ SSRI Deprescribing & Psychedelic Readiness Training with Dr. Dave Rabin: https://edu.psychedeliccoaching.institute/ssri-deprescribing-and-psychedelic-readiness-certification/?ref=12 Disclaimer: This content is for educational, informational, and entertainment purposes only. We do not promote or encourage the illegal use of any controlled substances. Nothing said here is medical or legal advice. Always consult a qualified medical or mental health professional before making decisions related to your health. The views expressed herein belong to the speaker alone, and do not reflect the views of any other person, company, or organization.

"I'd already finished my cardiovascular unit. I'd finished my pulmonary unit. I had never heard about this in any of my classes." That was Dr. Joel Bervell's reaction to discovering that a device used every day in hospitals -- the pulse oximeter -- reads less accurately on darker skin tones. He posted a 30-second video about this consequential discrepancy that, to his utter surprise, gained over 500,000 views by the next morning. That video launched Dr. Bervell into orbit as a social media presence and created his identity as The Medical Mythbuster. In just a few years, he's built a following of two million people, earned a Peabody Award and was named to the inaugural Time 100 Creators list, all while finishing his residency.  On this episode of Raise the Line, host Lindsey Smith welcomes Dr. Bervell to explore the roots of this kind of bias and the real world impact of drawing attention to it. “The most impactful biases in medicine exist because no one stops to ask who was included in the original data and who was left out,” Dr. Bervell explains. Stay tuned to also learn about: His YouTube animated series The Doctor is In which helps kids understand how their bodies work, as well as providing medical role models; How to build trust with marginalized communities; His forthcoming book, The Default Body which examines who medicine was actually designed for. Mentioned in this episode:Dr. Bervell on InstagramTikTok ChannelFacebook"The Doctor Is In" Show If you like this podcast, please share it on your social channels. You can also subscribe to the series and check out all of our episodes at www.osmosis.org/podcast

DopeyCon Tickets: https://buytickets.at/thedopeyfoundation/2345507 Patreon: www.patreon.com/dopeypodcast Summary / show notes This week on Dopey Wednesday! We open the Wednesday show with DopeyCon updates, listener comments and a voicemail from Oskar in Sweden. After leaving rehab with no intention of staying clean, Oskar returns home to ten grams of heroin, begins injecting with a friend and saves that friend from a potentially fatal overdose using naloxone. Poet/writer/'clinician' addict Zach Frank returns to discuss anxious attachment, fear, resentment and the difficulty of responding thoughtfully when emotions take over. He remembers passing out on heroin while running a bath, flooding his mother's house and destroying his brother's Xbox before the damaged ceiling collapsed in front of his grandmother. Zach then takes Dave inside the jam-band drug scene. On his way to a Dominican Republic festival, he convinces a cab driver to find cocaine, stops at a pharmacy for a huge box of Xanax, absorbs liquid LSD through his palm, urinates in the ocean fully clothed and later smokes a “silly stick”—a joint containing marijuana and DMT—during a Disco Biscuits set. He also describes his final festival before recovery: obtaining cocaine and Xanax, taking ketamine and powerful MDMA pills, and eventually reaching complete spiritual exhaustion. He calls his mother crying, returns to New York and enters treatment. Dave and Zach discuss the painful gap between becoming abstinent and genuinely feeling well, the first moments of peace that make recovery worthwhile, and why addicts sometimes need to hold on through weeks or months of discomfort. They celebrate Dave's 11 years sober and compare the Knicks' championship comeback to the seemingly impossible transformations found in recovery. The episode closes with listener comments and Dave's heartfelt—and musically questionable—tribute to Dolly Parton. All that and MORE! Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Gabe Snow joins Michael Chernow for one of the most raw and vulnerable conversations we've had on the podcast. Gabe opens up about childhood trauma, grief, addiction, steroid abuse, losing himself behind a seemingly glamorous lifestyle, and the moment he realized he needed to change. He shares how years of anabolic steroid use contributed to a shocking heart diagnosis, including discovering that his LAD artery was 40% blocked at just 34 years old. They also dive into body image, self-worth, nervous system regulation, breathwork, and what it actually takes to rebuild your life after years of running from yourself. Michael opens up about his own experiences with health, trauma, recovery, and a recent MDMA-assisted journey. This is a conversation about facing the parts of yourself you'd rather avoid and finding your way back to who you really are.Subscribe to The Michael Chernow Podcast for new episodes every week.KOHhttps://kreaturesofhabit.comIGhttps://www.instagram.com/michaelchernowhttps://www.instagram.com/kreaturesofhabit#MichaelChernowPodcast #GabeSnow #MentalHealth #AddictionRecovery #Breathwork

We Like Shooting We Like Shooting - Ep 677 August 24, 2026 Presented by This episode of We Like Shooting is brought to you by: Foxtrot Mike (Code: WLSISLIFE) C&G Holsters (Code: WLSISLIFE) Gideon Optics (Code: WLSISLIFE) Midwest Industries (Code: WLSISLIFE) Blue Alpha Night Fision (Code: WLSISLIFE) Otis Technology (Code: WELIKESHOOTING15) Guests: Paul – Foxtrot Mike – https://fm-products.com @foxtrotmikeproducts Giveaways!! GAW Text Dear WLS or Reviews +1 743 500 2171 Public Show Titles Gear Chat Note Gideon Optics on new Review guns. Note SCD Accidental Shooting coverage Note Foxtrot Mike Gen 2 Ranch rifles – Gun Fights Play the best Price Is Right-style GunBroker game on the internet. Gun Fights Live DisplayFollow the game, prices, and reveals as they happen.Open the live display BangRank A live cast ranking segment for anything and everything in the gun world, powered by questionable certainty, strong opinions, and audience voting. BangRank Live VotingScan or open the link to rank along with the show.https://welikeshooting.com/rank   Going Ballistic bearingarms.com (Savage) Navarre's Pastries Raid in Livingston Parish, Louisiana: 52 Firearms and Multiple Drugs Seized Louisiana bakery raided for drugs, guns; owner faces multiple charges in criminal enterprise case. On August 12, 2026, law enforcement executed a search warrant at Navarre's Pastries in Springfield, Livingston Parish, Louisiana, uncovering a reported distribution hub for nine types of drugs including cocaine, MDMA, and Adderall, along with 52 firearms (bolt-action rifles, pump-action shotguns, one AR-style rifle, one Japanese Type 11 machine gun, and one stolen from the Sheriff's Office) and $3,550 in cash. Owner Jules Navarre faces 62 charges, primarily 52 counts of possessing a firearm in the presence of a controlled dangerous substance, plus possession of a stolen firearm and nine counts of possession with intent to distribute various drugs. Sheriff Jason Ard described it as a narcotics distribution hub; the business is currently closed and Navarre remains in custody, presumed innocent pending trial. Louisiana law permits disposition of seized firearms via auction, transfer, or sale to an FFL upon conviction or plea. The Gist: Scope (who/what states are affected): The raid and charges affect Jules Navarre and Navarre's Pastries in Springfield, Livingston Parish, Louisiana; the operation appears local to Livingston Parish with no interstate or multi-state distribution details stated. Impact: Navarre faces 62 felony-level charges under Louisiana law, with the majority tied to firearm possession alongside controlled substances, plus drug distribution and stolen property counts; seized firearms may be auctioned, transferred, or sold to a federal firearms licensee post-conviction or plea, highlighting state-level enforcement of combined drug-gun offenses. – Bullet 3: Bottom Line: A Louisiana bakery was allegedly used as a local hub for drug distribution and illegal firearm possession, resulting in dozens of charges against the owner and seizure of 52 guns and narcotics; the case remains ongoing with presumption of innocence. bearingarms.com (Savage) Giffords Board Member Sari Horwitz Discovers Shocking Fact About the Politics of Gun Control Explore the politics and campaign finance dynamics behind gun control after school shootings. Sari Horwitz, former Washington Post reporter and new Giffords board member, wrote in The Atlantic that a study found pro-Second Amendment groups increased political contributions by over 30% (up to 2,820% near elections) after school shootings. Bearing Arms columnist Cam Edwards argues this reflects smart political responsiveness rather than cynicism, noting gun-control PACs increased spending similarly and surpassed pro-gun groups by 2018, with the study showing no measurable effect on election outcomes. The Gist: Affects U.S. national gun control advocacy groups including Giffords and pro-Second Amendment PACs; focuses on federal and competitive-district elections following school shootings. Impact: Highlights perceived hypocrisy in gun-control advocates labeling pro-gun spending increases as cynical while their own PACs engage in identical post-tragedy fundraising; reinforces arguments that gun rights groups effectively counter emotional pressure for new restrictions without proven electoral impact. Bottom Line: The article frames Horwitz's Atlantic piece as advocacy journalism that ignores symmetric behavior by gun-safety groups, concluding her claims should not be taken at face value. bearingarms.com (Savage) Bryn Mawr Garwood LLC v. Iron Horse R&R LLC (CAM-L-002643-26) NJ developer sues long-standing gun range over alleged environmental issues in a potential land grab dispute. Bryn Mawr Garwood LLC, controlled by Pennsylvania lawyer and real estate investor Harvey Sternberg, filed suit in Camden County Superior Court against Iron Horse R&R LLC, a gun club operating since 1947 in Gloucester Township, New Jersey. The complaint alleges environmental violations including improper solid waste disposal, soil stockpiling, and potential contamination affecting adjoining properties, seeking to halt range operations. Iron Horse characterizes the action as a land-grab attempt to facilitate residential development on the adjacent Waddell Property, with a public hearing scheduled for September 4. The Gist: Scope (who/what states are affected): The lawsuit targets Iron Horse gun range in Gloucester Township, Camden County, New Jersey; it involves the adjoining Waddell Property under contract to Bryn Mawr Garwood LLC for potential townhome development (context of 750 additional units) and directly affects the long-operating private gun club and local township enforcement actions. Impact: Claims center on untested “potentially contaminated” soil and environmental harm under implied state statutes, with Sternberg's $44k+ in donations to local Democrats and PACs since 2021 noted; the case raises concerns over regulatory use against established ranges to enable redevelopment, with Iron Horse optimistic ahead of the Sept. 4 hearing. – Bullet 3: Bottom Line: This Camden County suit (CAM-L-002643-26) pits a developer against a 79-year-old New Jersey gun range in what the club calls a land-grab; no soil testing has been conducted on the alleged contamination, and the dispute will proceed to public hearing on September 4. The Truth About Guns (Savage) Abdul El-Sayed Floated Replacing 2nd Amendment with Constitutional Right to Health Care (Michigan U.S. Senate Candidate, 2023 Video) Michigan Senate nominee Abdul El-Sayed once floated trading the Second Amendment for a right to health care. In a since-deleted April 6, 2023 YouTube video titled variations of “The Right to Bear Arms – The Right to Have Healthcare!”, Michigan Democratic U.S. Senate candidate Abdul El-Sayed proposed amending the Constitution by replacing the Second Amendment's right to keep and bear arms with a “right to have health care.” He argued the change would result in “fewer people dying by gun and more people living because they have healthcare.” The clips were removed prior to his Senate run; his campaign later stated that he “respects the Second Amendment, and also believes that access to healthcare is a right.” The Gist: Scope (who/what states are affected): The proposal was made by Abdul El-Sayed, a Democratic candidate for U.S. Senate in Michigan; it would require a national constitutional amendment under Article V and therefore affect the entire United States, with particular political relevance to Michigan voters in the 2026 Senate race. Impact: The suggestion revives debate over repealing or altering the Second Amendment, a change that would face insurmountable Article V hurdles (two-thirds of both houses of Congress plus three-fourths of the states) and trigger intense opposition from gun-rights groups; politically, the resurfaced 2023 video has drawn criticism and scrutiny of El-Sayed's past progressive positions on guns, police funding, and July 4th celebrations during his current campaign. – Bullet 3: Bottom Line: El-Sayed's now-deleted video explicitly floated trading the individual right to keep and bear arms for a constitutional “right to health care” on the theory it would save more lives; the idea remains aspirational rhetoric with no legislative traction, and his campaign now emphasizes respect for the Second Amendment alongside support for expanded healthcare access. townhall.com (Savage) Gavin Newsom Signs the Stop Nick Shirley Act (AB 2624) Into Law Gov. Gavin Newsom signs the controversial Stop Nick Shirley Act, raising free speech and journalism concerns. On August 23, 2026, California Governor Gavin Newsom signed Assembly Bill 2624, known as the “Stop Nick Shirley Act.” The legislation targets citizen journalist Nick Shirley's investigations that exposed fraud schemes in nonprofit and government programs in California and Minnesota. It restricts publication of certain nonprofit information and prohibits unauthorized recordings or photographs of employees and volunteers. The Gist: Scope (who/what states are affected) The law applies only to California, imposing restrictions on nonprofit organizations, their employees, volunteers, and individuals conducting investigations or journalism within the state. It does not extend to other states. Impact: Legal/Political Impact The bill creates new limits on recording, photographing, and publishing information about nonprofits, with potential fines and imprisonment for violations. Opponents, including Senator Tony Strickland, Carl DeMaio, and Eric Daugherty, argue it chills free speech, journalism, and accountability efforts,...

In this classic radio episode, Savage explores the question, "What is truth?" through a mix of politics, religion, immigration, personal experience, and warnings about psychedelics. He and callers discuss psychedelic drugs, including LSD, psilocybin, and MDMA, with callers describing frightening experiences, addiction, trauma, and lasting psychological consequences. Savage questions claims about the therapeutic benefits of psychedelics and challenges the overly optimistic media narratives surrounding them. Savage and callers converse on themes of reality, ego, faith, and human survival and conclude with warning that audiences should remain alert to manipulation and deception.

Despite gains in recent years, Black, Hispanic, and Asian communities are still under-represented in the U.S. nursing workforce. We're going to explore that gap and how to close it on this episode of Raise the Line from Elsevier with Dr. Ernest Grant, Vice Dean for Diversity, Equity, Inclusion and Belonging at the Duke University School of Nursing. "You get a patient who is more compliant when they see someone who looks like them, who is from their culture and who can advocate on their behalf," he tells host Lindsey Smith.  Dr. Grant bases that and other insights on a rich professional background that includes 50 years in nursing, being a leading advocate for his profession and breaking down barriers himself as a male nurse of color and the first man elected president of the American Nurses Association.  In this thoughtful conversation, Dr. Grant reflects on what it took to earn credibility in leadership roles, how he's navigating the political climate on DEI initiatives, and the causes and solutions to the persistent shortage in nursing faculty, among other pressing issues. Tune in for a uniquely-informed look at what it will take to build a stronger, more representative nursing profession. Mentioned in this episode: Duke University School of Nursing American Nurses Association If you like this podcast, please share it on your social channels. You can also subscribe to the series and check out all of our episodes at www.osmosis.org/podcast

Get Discounted Dopeycon tickets @ www.patreon.com/dopeypodcast Or Buy them full price @ https://buytickets.at/thedopeyfoundation/2345507 Summary / show notes On this Dopey Tuesday Teaser, Dave records alone while his family is away, cooks what he declares may be history's greatest air-fried chicken thighs and gives the Dopey Nation his complete 420-degree recovery meal recipe. Then Snake from the UK delivers a classic festival disaster. On the way into Bang Face, a rave filled with hardcore electronic music and drugs, Snake removes an enormous assortment of ketamine, MDMA, cocaine, weed, 2C-B and acid from his pants so he can urinate. He fails to put everything back properly—and the entire stash falls onto the ground directly in front of security. After the bouncers confiscate both his drugs and his friend Damon's supply, the pair drink a bottle of Kraken rum and quickly replace everything inside the festival. Loaded on speed, acid and alcohol, Snake gets grabbed by security again. Convinced they're returning to steal his soul, he climbs through a tiny bathroom window “like a spider monkey” and runs across the festival. By the end of the weekend, he and Damon become famous as the guys who continually get their drugs confiscated. Dave then reads listener reactions to the Jason Mewes interview—including theories about why celebrity guests avoid him, whether Mewes thought Dave was named Mark and the audience's collective childhood crush on Jay. Finally, Handsome Evan returns to discuss fatherhood, paternity leave and working inside a state psychiatric facility. The full SHOW —including psych-ward chaos, a crack-and-shit voicemail and much more—is available only on Patreon.     Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Matt delves into how psychedelics like psilocybin and LSD quiet the "Default Mode Network" to boost neuroplasticity. He describes these molecules as a "crowbar" that allows therapy to break deep-seated patterns of depression and reorganize the mind.Matt also reviews MDMA and ketamine trials for PTSD and trauma. While noting the brain's capacity for rapid change, he addresses research risks like the "blinding problem" and debunks microdosing myths. In essence, today's episode presents a balanced look at this evolving psychiatric frontier.Please note that Matt is not a medical doctor, and none of the content in this podcast should be considered medical advice in any way, shape, or form, nor prescriptive in any way.In a supplement industry where trust is critical, Matt uses podcast supporter Puori. Their protein powders are free from hormones, GMOs, and pesticides, with every single batch third-party tested for over 200 contaminants. For protein you can trust, save 20% at puori.com/mattwalker.Matt uses podcast sponsor Square for a reason: it's seamless, fast, and smart. From Apple Pay to real-time tracking, Square makes getting paid the easiest part of business. No hidden fees or contracts, just tools that scale with you. Get up to $200 off hardware at square.com/go/mattwalker. As always, if you have thoughts or feedback you'd like to share, please reach out to Matt:Matt: Instagram @drmattwalker, X @sleepdiplomat, YouTube: https://www.youtube.com/@sleepdiplomat

In this episode of The Psychedelic Podcast, Paul F. Austin welcomes Dr. Remi Drozd back to explore ketamine, SSRIs, and the changing landscape of psychedelic mental health care. Find full show notes and links here: https://thethirdwave.co/podcast/episode-369/?ref=278 Since Remi first appeared on the podcast in Episode 182, Lucid Therapeutics has grown from a small ketamine practice into a ten-room interventional mental health clinic offering ketamine treatments, Spravato, TMS, therapy, integration support, and other approaches. Paul and Remi examine one of the less-discussed challenges facing psychedelic medicine: many prospective patients are already taking antidepressants and other psychiatric medications. Remi explains why SSRI tapering needs to be individualized, how ketamine may support some patients through treatment transitions, and what clinicians may need to consider as psilocybin and other psychedelic therapies move closer to mainstream clinical use. Dr. Remi Drozd is a board-certified physician and founder of Lucid Therapeutics in Santa Barbara. After 15 years practicing emergency medicine, he shifted toward more integrative approaches to mental health care. He has trained in ketamine therapy and MDMA-assisted therapy through MAPS. His work focuses on individualized care, expanding access, and preparing for how emerging psychedelic treatments may fit into the existing mental healthcare system. Highlights: The growth of Lucid Therapeutics Expanding access through insurance-based care Navigating ketamine alongside SSRIs Why SSRI tapering must be individualized Withdrawal versus the return of depression Preparing patients for future psilocybin therapy The infrastructure required for psychedelic treatment Bringing longer psychedelic sessions into existing clinics Episode Links: SSRI Deprescribing & Psychedelic Readiness Training: https://edu.psychedeliccoaching.institute/ssri-deprescribing-and-psychedelic-readiness-certification/?ref=8 Lucid Therapeutics: https://www.thelucid.life/ Disclaimer: This content is for educational, informational, and entertainment purposes only. We do not promote or encourage the illegal use of any controlled substances. Nothing said here is medical or legal advice. Always consult a qualified medical or mental health professional before making decisions related to your health. The views expressed herein belong to the speaker alone, and do not reflect the views of any other person, company, or organization.

A wide-ranging conversation about identity, therapy, psychedelics, and artificial intelligence. He shares how his own origin story shaped his understanding of narrative agency, self-knowledge, and the limits of expert systems. The discussion also digs into the promise and risks of combining EMDR, ketamine, MDMA, psilocybin, and AI in therapeutic work. MARK A. MICHAELS, a writer and conceptual artist. Mark's work examines fundamental paradigm dilemmas in both traditional psychotherapy and contemporary psychedelic therapy. In his forthcoming preprint, BINARIES, MULTITUDES, AND BEYOND, Mark focuses the lens on his own journey and uses narrative analysis and critique to explore how authority, expertise, and healing are currently defined. https://markamichaels.com/about/ Key topics In this episode, Mark Michaels explains why he calls himself an "uncontrolled experiment" and how being conceived through artificial insemination shaped his worldview. The conversation covers the secrecy and social shame around sperm donation, infertility, and the long-term effects of not knowing one's biological origins. Mark describes the eight-year process of uncovering his biological father through research and DNA testing, and how that discovery changed his sense of self. He connects that origin story to his interest in identity, narrative agency, psychotherapy, and the promises and limits of science. Mark discusses his early exposure to therapy as a child and his teenage experimentation with LSD, including an early bad trip and later renewed interest in psychedelics. The episode centers on his recent treatment program combining EMDR, ketamine, MDMA, psilocybin, and AI-assisted reflection after a severe post-divorce mental health crisis. Mark argues that ketamine-assisted EMDR can accelerate therapeutic work by making clients more open and reducing psychological defenses. He is sharply critical of therapy culture when it becomes passive, overly rigid, or unwilling to share power with clients. The conversation examines the shortcomings of therapist training, especially when practitioners cling to one modality and fail to support client-led exploration. Mark and the hosts discuss the "wild west" state of psychedelic therapy, including concerns about over-medicalization, bad actors, and unregulated practice. The AI section focuses on both usefulness and danger, including hallucinated facts, false confidence, "kissing my butt" responses, and the risk of reinforcing poor psychological ideas. Mark explains that AI is best used as a high-speed organizer and drafting tool, but only if the user already has enough subject knowledge to challenge errors. The episode closes with Mark encouraging people in crisis to get help, evaluate whether therapy is actually working, and seek support rather than enduring alone.   To gain access to the second half of show and our Plus feed for audio and podcast please clink the link http://www.grimericaoutlawed.ca/support. For second half of video (when applicable and audio) go to our Substack and Subscribe. https://grimericaoutlawed.substack.com/ or to our Locals  https://grimericaoutlawed.locals.com/ or Patreon https://www.patreon.com/grimericaoutlawed   Support the show directly: https://open.spotify.com/show/2punSyd9Cw76ZtvHxMKenI?si=ImKxfMHgQZ-oshl499O4dQ&nd=1&dlsi=4c25fa9c78674de3 Watch or Listen on Spotify https://www.simulationmaps.com/#products Disaster Maps, Volcano Sim, Asteroid Sim, Shipwreck Map, UFO Map etc https://grimericacbd.com/ CBD / THC Tinctures and Gummies https://grimerica.ca/support-2/ Our Adultbrain Audiobook Podcast and Website: www.adultbrain.ca Check out our next trip/conference/meetup - Contact at the Cabin www.contactatthecabin.com Join the chat / hangout with a bunch of fellow Grimericans  Https://t.me.grimerica grimerica.ca/chats   Discord Chats Darren's books www.acanadianshame.ca Sign up for our newsletter http://www.grimerica.ca/news InstaGRAM https://www.instagram.com/the_grimerica_show_podcast/  Purchase swag, with partial proceeds donated to the show www.grimerica.ca/swag ART - Napolean Duheme's site http://www.lostbreadcomic.com/  MUSIC Tru Northperception, Felix's Site sirfelix.bandcamp.com    Timestamps 00:00 - Mark Michaels introduction and the intersection of psychotherapy, psychedelics, and AI 02:06 - Why he calls himself an "uncontrolled experiment" 03:11 - How commercial sperm donation worked in the 1950s and 1960s 05:08 - The secrecy around donor insemination and the lack of research on its effects 06:07 - Searching for his biological father and the role of DNA testing 08:40 - Genealogical bewilderment and how his origin story shaped his identity 10:06 - Why he feels uniquely positioned to think about AI and artificial reproduction 11:35 - Early therapy, teenage LSD use, and returning to psychedelics later in life 12:42 - The family crisis that pushed him to investigate his origins 14:33 - The emotional impact of learning the truth about his conception 17:01 - Shame, infertility, and the cultural pressure to become a parent 18:48 - How his background informs his preprint on binaries, multitudes, and beyond 20:19 - Building a treatment protocol with EMDR, ketamine, MDMA, and psilocybin 22:56 - Suicidal ideation, post-divorce crisis, and the need for a different intervention 24:21 - Using recordings and AI transcripts as part of the therapeutic process 25:23 - Reclaiming narrative agency after a decade of stress and distortion 27:05 - Problems with therapy when the therapist refuses to adapt or share power 29:37 - Training gaps and the limits of single-modality thinking in therapy 33:13 - Why intensive therapy may be more effective and cost-efficient than weekly sessions 34:38 - SSRIs, suicidal ideation, and Mark's experience with Prozac and stimulants 37:42 - Concerns about over-regulating or over-medicalizing psychedelic therapy 39:23 - His current ketamine practice as a creative, spiritual, and therapeutic tool 40:18 - Sweat lodges, ceremonial practice, and cultural context 41:18 - Plastic shamans and the long history of spiritual tourism 44:07 - Similarities across indigenous traditions and why they do not mean the same worldview 45:35 - Brain structure, recurring symbols, and the limits of universal explanations 47:56 - AI as a psychological tool and the problem of overly agreeable responses 49:41 - How AI absorbs watered-down pop psychology 50:47 - Hallucinations, invented citations, and the danger of trusting AI blindly 53:44 - What AI is genuinely good at: organizing large amounts of material 54:42 - Why Mark wrote the paper now and what he hopes it sparks 55:43 - Advice for people in crisis: get help and reassess therapy if it is not working 56:22 - Why ketamine can function as a rapid antidepressant stopgap 58:01 - What's next: peer review, the MFA program, and more writing  

The HSE's National Clinical Lead on Addiction Services, Prof. Eamon Keenan joins Brendan to discuss drug use at festivals emphasising that the best way to stay safe is not to consume drugs. He outlines what HSE services are on site at festivals, what spiked drugs are circulating in Ireland, and what harm reduction strategies users should adopt.

Se celebró el primer encuentro de medicina psicodélica en Puerto Rico, y lo cubrimos en vivo en PPP Live!Psilocibina, MDMA y terapias que están cambiando el tratamiento de la depresión, el trauma y la ansiedad. ¿Está Puerto Rico listo para esto? Hablamos de la ciencia, los retos legales y qué puede pasar con estas terapias en la isla.Déjanos tus preguntas en el chat.

In this Adventures Through The Mind micro, I explain what MDMA is and why it makes us feel love. I explain why MDMA is an entactogen rather than a classic psychedelic, and how it floods the brain with serotonin. I also discuss how it raises our sense of safety, lowers our sense of danger, and drops the emotional boundaries we normally hold, which is what made it work in couples therapy. Finally, I cover the PTSD research, and why MDMA with someone new can leave you holding an intimacy you have not earned. (00:00) What MDMA is, and how it works in the brain (06:25) Love with a capital L (11:02) Safety, danger, and the boundaries that drop (14:36) Why MDMA worked in couples therapy (18:14) The intimacy trap, and MDMA for PTSD (21:41) Outro This is a clip from 'Psychedelics in Research & Practice | James W. Jesso', Adventures Through The Mind 200.

What does it take to compete on the world's biggest stage and then pivot to one of the most demanding training paths in professional life? Today's guest, Samantha "Sammy" Kolowrat, has done both, and she has some fascinating insights into the commonalities of those two worlds on this episode of Raise the Line. “Something that really drew me to medicine is the team atmosphere that's there as you work towards a common goal, and there's this level of intensity that's very reminiscent of the experiences I had as a professional athlete.” Originally from Prague, Kolowrat represented Czechia at six IIHF Women's World Championships and the 2022 Beijing Olympics, and also captained the Division I women's hockey team at the University of Vermont while earning degrees in biology and pharmacology.  As she starts an anesthesiology residency at Vanderbilt University, she credits her athletic career with shaping how she handles pressure, feedback, and teamwork in medicine. "The more I improve, the more knowledge I acquire, the more skills I hone, the better care my patients get," she tells host Lindsey Smith, describing what drew her to a field that rewards the same relentless fine-tuning as elite sports. This engaging conversation also explores: How crippling performance anxiety as a Division I athlete ended up preparing Kolowrat for the operating room; Why she was drawn to anesthesiology's "well-oiled machine" atmosphere; The mentorship gap she's working to close for the next generation of athlete-physicians. Mentioned in this episode: Vanderbilt University Anesthesiology Residency Program If you like this podcast, please share it on your social channels. You can also subscribe to the series and check out all of our episodes at www.osmosis.org/podcast

Send us Fan MailWhat if the things that hook you on your phone could actually teach you something about yourself?In this solo episode of Queerly Beloved, Wil shares insights from a recent intentional MDMA journey that led him into a deeper exploration of his relationship with technology, emotions, and different “parts” of himself.Through Internal Family Systems (IFS)–inspired parts work, Wil meets Ping Pong, a busy-body, stimulation-seeking part that wants him to experience everything life has to offer while also protecting him from difficult emotions. As well as Shy, a part that fears what might happen if Wil becomes too visible, successful, connected, or happy.As these parts begin to soften, a bigger realization emerges: the algorithms on our phones may be especially good at identifying—and hooking—the vulnerable parts of ourselves.What if the reels that trigger our envy, FOMO, desire, insecurity, outrage, or need for validation aren't just distractions? What if they can also become trailheads—opportunities to get curious about what is happening inside us?In this episode, Wil explores:How parts work can help us relate to ourselves with more curiosity and compassionThe connection between busyness, stimulation, and avoiding difficult emotionsWhy reaching for our phones can sometimes be an emotional protection strategyHow social media algorithms can hook and feed different parts of ourselvesCreating greater sovereignty and intentionality in our relationship with technologyAllowing sadness, anger, and fear to actually move through the bodyThe unexpected freedom that can come from realizing we don't have to fill every momentFour messages Wil has been carrying since the journey:It is safe to be here.It is safe to feel.It is safe to shine.It is safe to connect.This episode also offers a personal prelude to Wil's upcoming conversation with Shannon Algeo, author of The Power in Your Hands, exploring our individual and collective relationship with smartphones and technology.The next time you find yourself compulsively reaching for your phone or getting hooked by something in your feed, consider pausing before judging yourself.What part of you is getting hooked? What is it looking for? What might it be protecting you from? And what does it actually need?A note about this episode: Wil shares personal experiences with psychedelic medicines and altered states of consciousness. This conversation is offered for educational and personal-reflection purposes only and is not medical, psychological, or legal advice, nor is it intended to encourage anyone to engage in illegal activity.Learn more about Wil and his work here- https://www.wil-fullyliving.com/Support the show

This was one of the most special podcast episodes I've recorded to date, especially since it was the first time it was recorded LIVE! We gathered for GALILEA's Gathering — an intimate evening that brought together clinicians, researchers, founders, and facilitators for a real conversation about the future of women's health. I had the privilege of recording a live interview with neuropharmacologist and GALILEA creator Stephanie Karzon right there in the room, surrounded by people who are genuinely building something new A core focus of our conversation was mapping out why hormones and life stages are important to factor into female care and why they're especially needed for the psychedelic experience, from a biochemical perspective and for the lived experience. A psychedelic-informed lens in women's care has now become non-negotiable; since clients will likely explore these medicines with or without capable practitioners willing to guide them. And let's face it, current pharmacotherapy isn't enough. Identity and spirituality matter in clinical practice. We need to bring hormone and cycle awareness into practice, as well as the relationship between estrogen, serotonin, glutamate, and psychedelic medicine. Stephanie Karzon Abrams is a clinical neuropharmacologist, founder of Beyond Consulting—powering the integrative and psychedelic medicine spaces by bridging emerging research with clinical practice, and designing clinics and healing centers from the ground up. She serves as Clinical Director at Mystic Health, is an associated prescriber of MDMA and psilocybin therapy under Canada's SAP, and is the Research Director at the Microdosing Collective non profit. Stephanie believes in the undercurrent of joy and authenticity woven into the fabric of our existence, and thus creates talks and workshops where the human experience is explored through the lenses of science, culture, and celebration. With experience in neurology, intensive care, and medical devices at Johnson & Johnson, she is a recognized leader in innovative healthcare. Her work bridges neuroscience, women's health, plant medicine, and the healing power of music. A musician, writer, and speaker, Stephanie also builds community through gatherings rooted in music and meaning through her label Public Secret. Connect with Stephanie via: Email: stephaniekarzon@gmail.com Website: Beyond Consulting, Stephanie Karzon Abrams, Galilea Health IG: @steph__k, @galileahealth Linked In: Beyond Consulting WhatsApp: galileahealth.community YouTube: Stephanie Karzon Abrams Gift: Womens Health Toolkit https://drive.google.com/drive/folders/1eiNj8zAaHlPK3CZPLdqh2QInmDrGbCQ2?usp=drive_link Visit https://marinabuksov.com for more holistic content. Music from https://www.purple-planet.com. Disclaimer: Statements herein have not been evaluated by the Food and Drug Administration. Products listed are not intended to diagnose, treat, cure, or prevent any diseases.

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The FDA rejected MDMA-assisted therapy for PTSD after the best trial results ever recorded for the disorder, because the patients could tell they were on the drug. That decision is the cleanest proof of the psycho-history series thesis: we have turned science into a ritual, and the ritual now outranks the truth. This episode covers the 2024 FDA decision, why the placebo effect is actually the ritual of care working, why noticing may be the mechanism of action psychology cannot admit, the fake Nobel Prize in economics, Porter's Trust in Numbers, the invalid DSM, Wampold's missing active ingredient, and how institutions develop defenses exactly like people do. Then Christopher Nolan's The Odyssey, the IMAX projectors nobody can build anymore, and what it means that we can no longer build the things we know we need. Part one of two. Part two: oil. MDMA FDA decision, MDMA therapy PTSD, FDA rejects MDMA, psychedelic therapy, randomized controlled trial problems, placebo effect explained, placebo studies, open label placebo, evidence based practice criticism, DSM not valid, STAR-D study, Nobel Prize economics fake, Hayek Pretence of Knowledge, Theodore Porter Trust in Numbers, Bruce Wampold common factors, psychotherapy research, Christopher Nolan Odyssey, Odyssey IMAX 70mm, IMAX film projector, Bronze Age collapse, psycho-history, Jungian psychology, depth psychology, Taproot Therapy   Free resources: gettherapybirmingham.com. Support the show with code TAPROOT at Hardy Nutritionals.

DR PAM KRYSKOW is the medical lead for the Roots To Thrive Program. She is actively involved in research related to psilocybin, MDMA, ketamine and front line health care workers and first responders’ mental wellness. She is co-investigator on the largest microdosing study Microdose.me. Home

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An 11-year-old boy in rural Zambia once told Dr. Genesis Mwamba that he was about to attend school wearing shoes for the first time in his life. That moment, Dr. Mwamba says, crystallized why he started the Lead Me Back Foundation to provide school supplies and other support to marginalized communities in his native country.   As you'll learn in this inspiring installment in our NextGen Journeys series, Dr. Mwamba started the foundation in 2021while still a medical student because he had experienced the power of education as an “equalizer” in his own life, taking him from humble roots to a career in medicine. He and his colleagues have grown the bootstrapped organization to a point where it now provides hundreds of thousands of people across the country with educational access, climate education and community health clinics. “I've always been drawn to opportunities and initiatives that bring help to humankind,” he tells Raise the Line host Dr. Parsa Mohri. This episode also explores: What building "with" a community rather than "for" it looks like in practice; The storytelling strategy that attracted donors and partners; How his mother's untimely death inspired his commitment to preventive medicine.   Mentioned in this episode: Lead Me Back Foundation If you like this podcast, please share it on your social channels. You can also subscribe to the series and check out all of our episodes at www.osmosis.org/podcast

Sam Harris speaks with Neal Brennan about the experiences that shaped his life and work. They discuss Sam's mother's television career, growing up with an absent father, his struggles with perfectionism, his first experience with MDMA, dropping out of Stanford, meditation retreats, spiritual charisma and claims of psychic powers, the illusion of self, the limits of pacifism, deleting Twitter, Trump and the politics of shamelessness, hypocrisy and vice signaling, the future of American democracy, and other topics. If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at samharris.org/subscribe.

This episode was sponsored by Cardiff & Dutchess Cookies   LightSpeed VT: https://www.lightspeedvt.com/ Dropping Bombs Podcast: https://www.droppingbombs.com/ Today's Dropping Bombs episode delivers a raw redemption story with Patrick Poix, co-founder of Duchess Cookies — the New York stuffed-cookie brand now flying off shelves after Patrick traded a decade behind bars for a second shot at life.   Patrick breaks down the teenage MDMA deal that spiraled into a federal conspiracy charge, his run to France on a second passport, the ten years he served after 9/11 shut down his escape route, and how he rebuilt everything — his family, his freedom, his empire — one cookie at a time.   Whether you're chasing a comeback, building a business, or just love a story that shouldn't have a happy ending but does, this one's for you.    

128. Ancestral Trauma & Psychedelic IntegrationA 45-year psychedelic guide on ancestral trauma, Internal Family Systems, and why integration, not the ceremony, is the real medicine.Episode SummaryMost conversations about psychedelics stay at the level of the ceremony: the dose, the visions, the breakthrough. This episode goes somewhere else. Sand Symes has spent 45 years supporting women, first as a social worker, then as what she calls a modern medicine woman, and she doesn't talk about psychedelics as a fix. She talks about them as a way back to parts of yourself that got buried decades ago and never fully addressed. In this live recording from Psychedelic Salon at Town Hall Seattle, Sand walks through Internal Family Systems, the neuroscience of fear memory, the "trauma of overdoing" that hides inside high-functioning women, and why psychedelic integration for women is the part almost everyone underestimates. If you've ever wondered what actually happens after the journey ends, this is that conversation.

Dr. Lowan Stewart is not just someone who opened a ketamine clinic. He is someone who built the infrastructure for an entire country to access it.In this conversation, Sam sits down with Dr. Stewart, an emergency physician who co-founded the first ketamine clinic in New Mexico in 2016, brought ketamine therapy to Norway two years later, established the first public ketamine treatment unit in Scandinavia, and played a central role in Norway becoming the first country in the world to approve national public reimbursement for off-label ketamine in treatment-resistant depression.What makes Dr. Stewart's story particularly resonant for our audience is how familiar the starting point will feel. An EM physician who loved his work but felt the limits of what emergency medicine could do for the river of suffering flowing through the department. A side project that became a calling. An uphill battle against institutional skepticism that most providers in this space will recognize immediately.He also brings a perspective on the future of psychedelic medicine that is worth hearing. His argument is straightforward: ketamine is not just a treatment. It is the infrastructure that will make everything else, psilocybin, MDMA, and what comes after, possible in clinical and public health settings. Getting ketamine right now is how the field prepares for what is coming next.This is a wide-ranging conversation covering career pivots, pioneering in resistant systems, the mechanics of moving a national healthcare system, and the daily reality of doing work that genuinely transforms lives.What you'll gain:• The full arc of Dr. Stewart's career pivot from emergency medicine to ketamine therapy, including what pushed him toward something with more systemic and sustainable impact than the ER could offer• A firsthand account of what it actually looks like to be the first mover in a resistant healthcare system, from opening the first ketamine clinic in New Mexico to fighting a formal complaint from the Norwegian Psychiatric Association• How Dr. Stewart built the first public ketamine treatment unit in Scandinavia and the strategy behind getting ten major Norwegian hospitals to implement ketamine therapy simultaneously through a multi-site clinical trial• What Norway's landmark decision to become the first country in the world to approve national public reimbursement for off-label ketamine in treatment-resistant depression means for the global field and what other countries can learn from it• Why Dr. Stewart believes ketamine is not just a treatment but the infrastructure that will determine how ready clinical and public health systems are when psilocybin, MDMA, and other psychedelic medicines arrive• His honest reflection on why this work is worth it, including what it feels like to shift from focusing on the quantity of life in the ER to focusing on the quality of life in ketamine therapyEpisode 62 show notes:00:00:00 Teaser: "Once somebody says, 'I'm alive today because of this treatment,' you can't not do it."00:00:24 Episode Introduction00:02:19 Sam Welcomes Dr. Lowan Stewart00:02:53 Background Overview: Emergency Medicine, Norway, and the Journey to Ketamine00:08:56 Why Neuroscience: Starting an MD-PhD and the Rat Brains Advice00:10:09 From Space Medicine Dreams to Emergency Medicine Reality00:12:14 The Decision Point: Going Away from EM or Toward Something New?00:15:37 Opening the First Ketamine Clinic in New Mexico: What the Ketamine World Looked Like in 201600:17:55 Bringing Ketamine to Norway: Opening Axon Clinic in 201800:20:06 Approaching the Norwegian Psychiatric Association and Health Department with the Data00:26:40 Psychiatrist Skepticism: "I Don't Know What to Do with These Patients If They're Fine"00:28:29 The Formal Complaint from the Norwegian Psychiatric Association00:31:23 Establishing the First Public Ketamine Treatment Unit in Scandinavia00:34:34 Axon Clinic's Acquisition by Awaken Life Sciences and the Ukraine War Impact00:40:18 Norway's Landmark Approval: National Public Reimbursement for Off-Label Ketamine00:44:20 The Multi-Site RCT Strategy: Implementing Ketamine Across Ten Major Norwegian Hospitals00:50:17 Why Ketamine Gets Overlooked at Psychedelic Conferences and Why That Needs to Change00:55:14 One Piece of Advice for Any EM Physician or Clinician Considering This Pivot00:58:34 Rapid-Fire Questions00:59:07 How Dr. Stewart De-Stresses: Cold Ocean Swims and Sauna in Norway01:02:17 How to Connect with Dr. Lowan Stewart01:04:03 Episode EndingThanks for listeningConnect with Dr. Stewart at:Clinic Website - Axonklinikken http://axon.no/ Email: lowan@axon.noLinkedin: https://www.linkedin.com/in/lowan-stewart-27349616/

This is the first of a two part summer special with Laura Mae Northrup, who was first featured in the original BFTA summer special back in 2022. In this first episode, in an excerpt from her wonderful podcast called Inside Eyes, we hear Laura describe her long and grueling battle with suicidality, which emerged as a result of childhood sexual abuse. In the second episode in two weeks, Laura and Dr. H dive deep into her personal healing journey— what worked, what didn't, and how she was able to finally put her chronic suicidality to rest. Support the showLaura Mae Northruphttps://www.lauramaenorthrup.com/Elemental Psychedelicshttps://www.elementalpsychedelics.com/Explore every episode through themes, domains, formats, and speakers. The BFTA CODEX is a listener-built and curated field guide to the podcast. https://bfta-codex.orgBFTA episode recommendations/Podcast pagehttps://www.craigheacockmd.com/podcast-page/BFTA on IG @backfromtheabysspodcasthttps://www.instagram.com/backfromtheabysspodcast/Support the show

Psychedelics, hallucinogens, natural medicines, you name it, we're covering it on this episode of the Pain Pod folks! We'll chat through all types of psychedelics including LSD, MDMA, Psilocybin, DMT, and Ketamine and beyond. No trippin' just learnin'! You're not going to want to miss this one! Come one, come all, to the Pain Pod!!! Pain Guy www.painguy.us

"We have an untapped army of 200,000 PAs that really could step up and drive some change in the healthcare system if we weren't restricted,” says Dr. Jennifer Kolb, capturing her motivation for pushing to update practice regulations for physician associates that date back more than 50 years.  As Chief Medical Officer and Senior Vice President of Clinical Affairs at the American Academy of Physician Associates, Dr. Kolb has been in the middle of the fight at the state and federal level to grant PAs more independence from physicians, full billing rights, and the increased ability to practice across state lines, among other changes.  In this pertinent conversation with Raise the Line host Lindsey Smith, Dr. Kolb explains how these updates could help close huge gaps in access to healthcare, better manage the fight against chronic diseases and improve patient outcomes.   Dr. Kolb also addresses:  Why the name shift from "assistant" to "associate" took her years to fully appreciate; How a 10-year gap in life expectancy across Chicago zip codes shapes her view of health equity; Why PA's shouldn't wait for permission to start making change in their communities. Mentioned in this episode:American Academy of Physician Associates   If you like this podcast, please share it on your social channels. You can also subscribe to the series and check out all of our episodes at www.osmosis.org/podcast

Psychedelics, hallucinogens, natural medicines, you name it, we're covering it on this episode of the Pain Pod folks! We'll chat through all types of psychedelics including LSD, MDMA, Psilocybin, DMT, and Ketamine and beyond. No trippin' just learnin'! You're not going to want to miss this one! Come one, come all, to the Pain Pod!!! Pain Guy www.painguy.us

Psychedelic Therapy for Mental Health: Research, Safety, and the Path to FDA Approval: Dr. Will Van Derveer and Keith Kurlander, co-authors of “Psychedelic Therapy: A Revolutionary Approach to Restoring Your Mental Health and Reclaiming Your Life,” reveal the shift from recreational psychedelics to structured, research-based psychedelic-assisted therapy for conditions like PTSD, depression, and anxiety. Van Derveer describes limitations of conventional psychiatry (citing STAR*D remission rates) and his entry into MDMA-assisted PTSD research after promising results. They contrast controlled clinical protocols—screening, preparation, safe setting, trained facilitation, medical monitoring, and post-session integration—with uncontained recreational use. The discussion covers current policy momentum under Trump and RFK Jr., VA interest for veterans, and key agents: ketamine (including abuse risks and clinic-only Spravato), MDMA (phase 3 but not approved in 2024), psilocybin (phase 3, potential FDA approval), LSD (GAD trials), ibogaine (arrhythmia risk, Mexico clinics), ayahuasca, peyote, and microdosing. They also note commercialization, including Eli Lilly's acquisition of a 5-MeO-DMT nasal spray developer, and emphasize an integrative “all-of-the-above” mental health approach.

Grief is one of the most universal yet isolating experiences we endure—and psychedelics may offer a path through it. This Salon explores how substances like psilocybin, MDMA, and 5-MeO-DMT are being used to support those navigating loss, whether from death, identity shifts, or life transitions. This session sheds light on how altered states can help us reconnect to love, soften the sharp edges of sorrow, and reorient to a life forever changed. Attendees will gain insight into the science and integration practices that support emotional processing and meaning-making in the context of grief. Dr. Sunil Aggarwal is a physician in hospice and palliative medicine, physical medicine and rehabilitation, and a medical geographer. Dr. Aggarwal's primary clinical work is as an Integrative Pain, Palliative Care, and Rehabilitation Physician in private practice at the AIMS Institute in Seattle, Washington, and as an on-call Palliative and Hospice Physician within a Puget Sound–based healthcare system. He has a petition to reschedule psilocybin that is currently under review at the US Department of Health and Human Services. Dr. Aggarwal's medical geography scholarship focuses on the geographies of access, delivery, and development of cannabinologic and psychedelic integrative medicine—particularly as these relate to pain management, hospice and palliative medicine, and rehabilitation services. After two decades in journalism and content direction, Laura Sullivan Cassidy (she/her) used the early pandemic years to begin building a new career serving communities in grief and loss. She's trained as a grief work facilitator, creative coach, and death doula, and is employed at Recompose, the Seattle-based green funeral home known for pioneering the process of human composting. Her role at Recompose involves outreach, community, and client work—specifically with communities for whom a death is approaching, either via terminal diagnosis or hospice care. Laura writes a Substack called Griever's Ball and offers creative expression, listening groups, and death awareness workshops. — Psychedelic Salon: Cultivating Conscious Connections Join Seattle-based psychedelics educator and podcast host April Pride in a dynamic series co-produced with Town Hall Seattle. Psychedelic Salon explores the transformative potential of psychedelic medicines through engaging conversations, expert panels, and interactive community discussions. Rooted in scientific evidence, each event highlights unique themes—including grief, seniors, menopause, and more—emphasizing their role in mental health, spiritual growth, and personal optimization. Designed to be inclusive and insightful, this series invites attendees of all backgrounds to discover how psychedelics can foster profound connections, healing, and well-being. About April Pride April Pride is a Seattle-based creative entrepreneur and harm reduction advocate with over two decades of experience building brands at the intersection of lifestyle, cannabis, psychedelics, and women's health. Her work has been featured in The New York Times, Forbes, Vice, and The Guardian. April is the founder of SetSet, the world's first clinician-approved woman-focused platform for safe, accessible psychedelic integration. To learn more, follow April on Substack – aprilpride.substack.com

Most adults who smoke want to quit, and about half try to do so in any given year, yet fewer than one in ten succeed. That persistent gap between intention and outcome is one of the central challenges in public health, and it's exactly the kind of problem that calls for new thinking about how to communicate with people to support behavior change.  Dr. Amanda Graham has been a leading force in doing just that in her role as chief health officer at Truth Initiative, the nation's largest non-profit public health organization dedicated to preventing addiction among young people and helping people of all ages to quit tobacco. On this episode of Raise the Line from Elsevier, Dr. Graham, who holds a PhD in clinical health psychology and has done 25 years of NIH-funded research focused on technology-based cessation interventions, helps us understand the interplay between behavioral science and digital communications in the field. "A well-timed message can really be powerful in interrupting what for many people is kind of an automatic behavior, especially via text, which data tell us is an extraordinarily powerful modality,” she explains to host Lindsey Smith.  Tune-in to understand where the field is heading, and to learn about: Why "push" technology may work better than apps and websites when it comes to breaking automatic behaviors; How the rise of e-cigarettes, nicotine pouches, and heated tobacco has scrambled decades of public health messaging; How highschool smoking rates plunged from over 30% to less than 2%. Mentioned in this episode: Truth Initiative Program with Mayo Clinic If you like this podcast, please share it on your social channels. You can also subscribe to the series and check out all of our episodes at www.osmosis.org/podcast

Good morning from Pharma Daily: the podcast that brings you the most important developments in the pharmaceutical and biotech world. Today, we're delving into a series of significant breakthroughs and strategic moves reshaping the industry landscape. Repligen Corporation's recent decision to acquire BioLife Solutions for $1.5 billion marks a pivotal moment in the cell therapy sector. BioLife Solutions' expertise in cryopreservation media is integral to maintaining cell viability during storage and transport—an essential factor for the success of cell therapies in oncology and regenerative medicine. This acquisition ensures Repligen a stable supply chain to support the burgeoning demand for advanced therapeutic options, potentially enhancing patient outcomes through more reliable treatments. Meanwhile, Novartis is expanding its reach in South Korea with a $95 million investment aimed at enhancing its radioligand therapy supply chain. Radioligand therapy represents a groundbreaking approach in oncology, utilizing targeted radioactive particles to specifically attack cancer cells while sparing healthy tissue. This strategic investment underscores Novartis's commitment to ensuring a robust infrastructure for delivering innovative cancer treatments. On the clinical front, Crystalys Therapeutics has made waves by securing $130 million in Series B funding, propelling their gout treatment, Dotinurad, into Phase 3 trials. This drug targets uric acid levels, addressing a significant unmet need in gout management. The progression into late-stage trials reflects confidence in Dotinurad's potential to provide effective relief for patients suffering from this painful condition. Regulatory advancements are also making headlines with the UK's MHRA granting approval to Chiesi's Clenil Modulite with a low-carbon propellant for asthma maintenance treatment. This move signifies a crucial step towards more sustainable pharmaceutical practices without compromising efficacy—setting a potential benchmark for future respiratory treatments that incorporate eco-friendly technologies. In business development news, Ashlins Pharmaceuticals and Lee's Pharmaceutical have struck a $31 million licensing deal for interferon alpha-2b outside China, focusing on rare diseases. Similarly, Jupiter Neurosciences' acquisition of MDMA asset ALA-002 from Pharmala Biotech illustrates ongoing interest in small molecule therapeutics for neurological conditions. Royalty Pharma's significant $425 million payment to Neurimmune highlights strategic investments in cardiovascular therapies through royalty financing, underscoring confidence in advancing novel treatments. Concurrently, Dimension has raised an impressive $800 million for an AI-driven biotech drug discovery fund. The integration of AI promises accelerated drug development timelines and enhanced precision in identifying viable candidates. However, not every development is favorable. Celldex Therapeutics faced a setback with their Phase 2 trial failure for barzolvolimab in prurigo nodularis patients. Such challenges highlight the inherent risks associated with innovative drug development. Turning our attention to another scientific milestone, Arrowhead Pharmaceuticals has reported promising Phase 3 data on its triglyceride-lowering drug, Plozasiran. With analysts praising its "best-in-class profile," Arrowhead aims for FDA approval by year-end, setting up potential competition with Ionis Pharmaceuticals' Tryngolza. These advancements underscore significant progress in targeting specific lipid disorders and the promise of novel therapies to improve cardiovascular health. Corporate strategies are also evolving as seen with Sanofi undergoing executive restructuring under new leadership by CEO Belen Garijo. This reflects broader industry trends where leadership shifts align corporate strategies with market demands and scientific opportunities. Legal developments have not gone unnoticed either. Amgen's $74 million settlement over allegations of concealing a substantial tax bill highlights ongoing scrutiny over corporate governance within the sector. Meanwhile, industry giants are rallying around regulatory defenses, as evidenced by biopharma companies supporting the FDA amidst legal challenges concerning mifepristone—a move emphasizing the industry's vested interest in maintaining access to drugs based on scientific merit. From a technological perspective, companies are increasingly adopting connected trial technologies to streamline processes such as consent and reporting—advancements crucial for reducing patient burden and accelerating drug development timelines. In conclusion, these developments portray an industry at the forefront of scientific innovation while navigating complex regulatory environments and ethical considerations. As firms continue exploring novel treatment avenues and leveraging technological advancements like AI, they position themselves for transformative impacts on patient care and global health outcomes. We look forward to keeping you updated on these exciting trends shaping the future of pharma and biotech industries.Support the show

Psychoaktive Drogen wirken auf unser Gehirn. Die Medizin will diese Prozesse nutzen, um psychische Kankheiten zu behandeln. Ein Vortrag des Psychiaters Stefan Röpke über die aktuelle Studienlage.Stefan Röpke ist Chefarzt für Psychiatrie und Psychotherapie an den Oberberg Kliniken Berlin-Brandenburg. Außerdem ist er Traumaforscher an der Charité Berlin. Sein Vortrag heißt "Aktuelle Forschungsergebnisse: Sind Psychedelika und Cannabinoide wirksam bei der Behandlung psychischer Erkrankungen?" Gehalten hat er ihn am am 28.05.2026 im Rahmen der Ringvorlesung "Psychische Gesundheit im Fokus – zwischen Forschung, Praxis und gesellschaftlichen Herausforderungen" an der Freien Universität Berlin.+++ Deutschlandfunk Nova +++ Hörsaal +++ Deutschlandradio +++ Wissenschaft +++ Vortrag +++ Psychiatrie +++ Psychologie +++ psychische Krankheiten +++ psychische Gesundheit +++ Medizin +++ Medikament +++ Behandlung +++ psychoaktive Substanzen +++ Drogen +++ psychoaktive Drogen +++ MDMA +++ LSD +++ Psilocybin +++ Pilze +++ Ketamin +++ THC +++ Cannabis +++ DMT +++ Ayahuasca +++ Studien +++ Medikamentenstudien +++ Placeboeffekt +++ Doppelblindstudie +++ Zulassung +++**********In dieser Folge mit: Moderation: Nina Bust-Bartels Vortragender: Stefan Röpke, Psychiater, Ärztlicher Direktor der Oberberg Kliniken Berlin-Brandenburg, Traumaforscher an der Charité Berlin**********HörtippsDer Tag, ein Podcast des DeutschlandfunksHologrammatica, Science-Fiction-Thriller-Serie von Tom Hillenbrand**********Ihr hört in diesem Hörsaal:5:05 - Geschichte psychoaktiver Substanzen11:23 - Psychoaktive Substanzen in der jüngeren Geschichte19:04 - Klinische Forschung zu psychoaktiven Substanzen26:48 - Ketamin zur Behandlung psychischer Krankheiten30:53 - MDMA zur Behandlung psychischer Krankheiten33:45 - Psilocybin bei der Behandlung psychischer Krankheiten35:47 - DMT bei der Behandlung psychischer Krankheiten36:42 - LSD zur Behandlung psychischer Krankheiten38:53 - THC bei psychischen Krankheiten40:34 - Placeboeffekte42:22 - Fazit**********Mehr zum Thema bei Deutschlandfunk Nova:Ketamin: Oft als Partydroge missbraucht, wird auch gegen Depression eingesetztIllegale Partydrogen: Wie Paare versuchen, ihre Beziehung zu rettenDrogentote: Warum immer mehr junge Menschen sterben**********Den Artikel zum Stück findet ihr hier.**********Ihr könnt uns auch auf diesen Kanälen folgen: TikTok und Instagram .

Listen without ads on patreon: www.patreon.com/dopeypodcast This week on Dopey! We open the show with a deep dive into Lou Reed's classic junkie anthem "Waiting for the Man" before reading incredible listener stories involving MDMA-assisted therapy, smashing open a safe with an axe for OxyContin, smoking crack in an airplane bathroom, a horrific flesh-eating abscess, and surviving Antabuse mixed with opioids. Then legendary author Jerry Stahl returns for one of the funniest and deepest conversations Dopey has ever had. Jerry shares never-before-heard stories about writing for Twin Peaks, working with David Lynch and Ben Stiller, learning from Hubert Selby Jr., meeting William Burroughs' son, Oprah admitting she loved crack, surviving heroin addiction, and why kindness matters more than bitterness. The conversation ends with Dave pitching Jerry his outrageous action movie idea: Die Hard... at Katz's Delicatessen. PLUS MORE MORE MORE on a brand new yet timeless episode of that good old dopey show! Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

"I always remember feeling like I was part of the clean plate club," says Dr. Christle Guevarra, recalling a childhood spent quietly convinced that her weight was a matter of willpower. That belief followed her through a competitive powerlifting career and medical practice until she finally tried a GLP-1 medication herself and, as she describes it, the constant mental noise around food quieted down. Now a board-certified family and sports medicine physician, traveling team doctor for U.S. Figure Skating, and author of The Beginner's Guide to GLP-1s, Dr. Guevarra brings a rare combination of clinical authority and lived experience to the conversation around obesity medicine.  In this episode of Raise the Line from Elsevier, host Lindsey Smith talks with her about what's actually changed in how physicians understand the issue and what it means for patients. "The biggest thing is reframing how we approach weight loss. It's not just a willpower problem, it is a neurobiological problem." Tune in to learn about: Why she said no to a GLP-1 prescription for two years and what finally changed her mind; The real story behind concerns about muscle loss on these medications; What happens when the “food noise" goes silent and a new set of challenges takes its place.   Mentioned in this episode:  Dr. Christle's website If you like this podcast, please share it on your social channels. You can also subscribe to the series and check out all of our episodes at www.osmosis.org/podcast

Founder of Mind Medicine Australia and inspirational speaker Tania de Jong joins the Thrive Hour for an enlightening discussion about psychedelic medicine. She explains the remarkable critical learning period that psychedelics uniquely open—a short window of heightened neuroplasticity where the brain becomes far more adaptable (or, more simply, where the brain and body are temporarily reset back to a more youthful state, allowing them to learn, heal, grow, and expand again).  Scientists are now discovering that this unique window may become a powerful tool not only for expanding human potential, but also for helping the body heal from conditions such as PTSD, trauma, depression, stroke, Alzheimer's disease, Parkinson's disease, addiction, and many other neurological and mental health disorders. We also discuss why this emerging field of research could fundamentally change the way we think about healing, recovery, and human potential.See more at taniadejong.com or mindmedicineaustralia.org.au.

Why do neurofeedback practitioners get way better results than the published studies? A listener from the Neurofeedback Exchange Facebook group asked — and the panel spent the hour answering. Joy Lunt's short version: research runs in "the tightest handcuffs you could find." Jay Gunkelman brings the receipts: one artifacted EEG file sent to 15 commercial services came back as pure chaos — and the journal editor called the paper too embarrassing to publish, until Jay threatened to resign. Then the hard-criteria bombshell: standard protocols scored 30%, QEEG-guided hit 60%. Plus the $3M NIMH ADHD study that changed its hypothesis midstream, why BCIA certification doesn't guarantee a good provider, Jay's "the diagnosis world is imaginary," and the kid who lost 80 sessions of progress to one bike crash — and got it back in 24.

Millions of Americans were saddened and outraged by the Sandy Hook Elementary shooting in 2012 that took the lives of twenty children and six adults, and were left feeling helpless about the epidemic of gun violence in the U.S. that, sadly, continues to this day. But for our guest today, Shannon Watts, her feelings of devastation about the shooting turned to rage and fueled her unlikely rise to leading Moms Demand Action, which she grew into one of the largest grassroots organizations in the country, mobilizing millions of volunteers to push for stronger gun safety laws. “I wanted to stand shoulder to shoulder with a badass army of women because that's who gets things done in this country,” she says.    In this inspiring conversation with Raise the Line host Michael Carrese, Watts pulls back the curtain on how the group achieved its successes and the philosophy of "losing forward" that kept volunteers showing up year after year. In her recent book Fired Up, Watts describes how she is bringing insights from that experience to a new mission: helping women identify their values, abilities, and desires and acting on them without waiting until everything is perfect. Tune-in to learn about:  The "false fires" women mistake for passion; Why losing estrogen and testosterone in midlife might actually make women braver, not less so; The one exercise she does with every woman she coaches.  Mentioned in this episode: Fired Up book Moms Demand Action If you like this podcast, please share it on your social channels. You can also subscribe to the series and check out all of our episodes at www.osmosis.org/podcast

One honest conversation could save someone's life.In this episode of Girls Gone Gritty, Farley and Jennifer take on a hard but necessary topic: the changing drug landscape and why parents, teens, college students, and adults need to stay alert. They talk about how today's drugs can look harmless, smell sweet, or hide in familiar forms like pills, powders, drinks, gummies, and gas station products. From fentanyl and pink cocaine to GHB, ketamine, MDMA, Kratom, spice, and other dangerous substances, the hosts explain why “just trying it once” is no longer a casual risk.The biggest takeaway is clear: talk to your kids early, often, and honestly. Ask what they have seen. Teach them about peer pressure, party safety, social media exposure, and why they should never trust an unknown pill, drink, powder, or product. This episode is not about fear for fear's sake. It is about awareness, protection, and having gritty conversations before the world has them first.Episode Highlights:(0:00) Intro(2:44) Top three current events and Supreme Court discussions(10:44) Why today's drug risks feel more dangerous for this generation(12:09) Fentanyl, opioids, and why one exposure can be deadly(14:55) Pink cocaine, ketamine, MDMA, and misleading packaging(16:09) “Go fish” parties and prescription pills from medicine cabinets(17:31) Ketamine, Special K, and the danger of K-holes(18:31) GHB, party settings, and odorless substances(22:13) Talking to kids about peer pressure and social media exposure(23:26) Gas station drugs, Kratom, Phenibut, and legal gray areas(27:08) Spice, fake weed, vaping, and synthetic substances(28:30) Scopolamine, “devil's breath,” and personal safety awareness(31:08) Questions parents should ask their kids about drugs(33:11) Why gritty conversations can protect families(33:41) Got Grit Award: FEMA Urban Search and Rescue Task Force(35:33) Song of the week: “Into the Fire” by Bruce Springsteen(36:42) OutroSend us Fan MailSupport the showFollow us:Web: https://girlsgonegritty.com/Instagram: https://www.instagram.com/girlsgonegritty/More ways to find us: https://linktr.ee/girlsgonegritty

Curious about psychedelic medicine but unsure what it actually does? In this conversation, John Kim sits down with Sarah Williams to explore how medicines like MDMA and psilocybin can support healing, self-discovery, and personal growth when approached with intention, safety, and integration. Sarah shares her journey from her first ayahuasca experience to becoming a medicine guide, including the near-death experience on Denali that changed the course of her life. Together, they unpack why medicine isn't a shortcut to transformation, but a tool that can help people reconnect with themselves and create lasting change. In this episode: • Sarah's path into medicine work and what drew her to MDMA • Why integration matters more than expecting one ceremony to change your life • The lessons Sarah learned after surviving a life-threatening experience on Denali • How MDMA can help people access difficult emotions and conversations • The differences between macrodosing and microdosing • Why intention, safety, and the right support are essential John and Sarah also share details about their upcoming two-month microdosing program which you can find out about HERE Connect with Sarah: Instagram https://www.instagram.com/sarahskyann Website: https://www.terraalinea.com

This holiday weekend we celebrate the veterans who made our 250th anniversary possible. We all can agree that cannabis is an important tool in the rehabilitation of our nation's hero's that suffer un proportionally to the general population. Now we have even more tools on the toolbox thanks to psychedelics psilocybin, Ibogaine, MDMA all have shown incredible positive results and getting vets this life saving treatment is what @operationgreenhealing is all about. We will have our friend Terry in studio and CJ and crew zoom in and give us an inside scoop on the healing center that is in the works and fill us in on OGH which is a veteran-led non-profit dedicated to supporting military veterans through peer connection, education, and alternative therapies. Rather than providing medical treatments, the grassroots organization fosters a safe community space where veterans can explore plant medicine, share experiences, and support one another. So get that @puffco charged your @jerome_baker bong Clean with some ice

Epstein's Suicide Note, the SPLC's Nazi Romance & Jon Levine. UNSAFE w/ Ann Coulter Watch the entire video at- https://youtu.be/RWI-l2dUY40?si=idK7OHxrMivcF-Iq Ann Coulter 2.63K subscribers 1,287 views Jun 20, 2026 UNSAFE w/ Ann Coulter - live on 06/18/2026  In this full episode of UNSAFE w/ Ann Coulter, Ann runs through five stories: how California's vote-by-mail system is built for Democrats to steal elections, the New York Times investigation that convinced her Jeffrey Epstein really did die by suicide, the Southern Poverty Law Center staffer entangled with the neo-Nazi National Alliance, and the unraveling of venture capitalist Amy Griffin's MDMA-assisted 'recovered memory' memoir The Tell. Then Washington Free Beacon reporter Jon Levine joins to dig through the deleted tweets and academic writings of Darializa Avila Chevalier, the Zohran Mamdani-backed democratic socialist challenging Rep. Adriano Espaillat in New York's 13th Congressional District -- abolishing police, prisons, and schools, calling the American flag a dish rag, and cheering in Times Square on October 8th. Ann and Jon also debate jokes and cancel culture, Elon Musk and the death of the Twitter blue checkmark, whether Americans are the least racist people on earth, and New Jersey congressional candidate Adam Hamawy, the Princeton plastic surgeon who testified as a defense witness for the Blind Sheikh, Omar Abdel Rahman.  Topics: California election fraud, mail-in ballots, ballot harvesting, Jeffrey Epstein, New York Times, Southern Poverty Law Center, National Alliance, Amy Griffin, The Tell, recovered memory, Jon Levine, Washington Free Beacon, Darializa Avila Chevalier, Adriano Espaillat, Zohran Mamdani, NYC Democratic primary, abolish ICE, abolish police, school abolition, October 7, Hamas, Elon Musk, Twitter, cancel culture, Adam Hamawy, the Blind Sheikh, Omar Abdel Rahman, al-Qaeda. Watch live on Rumble: https://rumble.com/c/AnnCoulter TikTok:   / realanncoulter   X (formerly Twitter): https://x.com/anncoulter Substack: https://anncoulter.substack.com/

In this conversation, Paul F. Austin speaks with Dr. Dave Rabin, neuroscientist, board-certified psychiatrist, and co-founder of Apollo Neuroscience, about one of the most important questions in psychedelic work: why do some journeys become overwhelming, destabilizing, or difficult to integrate? Find full show notes and links here: https://thethirdwave.co/podcast/episode-362/?ref=278  Dave explains why safety is not just a matter of set, setting, or a strong screening form. It is a physiological state in the nervous system. Together, Paul and Dave explore how fear, trauma, and dysregulation can shape a person's ability to receive and process a psychedelic experience, and why preparation must include a deeper understanding of the body. The conversation also covers pre-session nervous system assessment, vagus nerve activity, HRV, haptic vibration, breathwork, therapeutic touch, consent, and the role of tools like Apollo Neuro in helping clients feel safe enough to surrender, process, and integrate. Dr. David Rabin, MD, PhD, is a neuroscientist, board-certified psychiatrist, health-tech entrepreneur, and inventor who has studied the impact of chronic stress in humans for more than a decade. He is the co-founder and Chief Innovation Officer at Apollo Neuroscience, and co-founder and executive director of the Board of Medicine, a nonprofit organization establishing evidence-based clinical guidelines for the safe use of unregulated alternative medicines, including plant medicines. His research focuses on non-invasive therapies for treatment-resistant conditions, trauma recovery, psychedelic-assisted psychotherapy, and the neurobiology of belief. Highlights: Why safety is physiological Beyond set and setting How fear interrupts healing Pre-session nervous system assessment MDMA and the safety cascade Haptic vibration and soothing touch HRV as a preparation signal Breathwork for embodied regulation Consent and therapeutic touch Scaling safe psychedelic care Episode Links: Apollo Neuro Dr. Dave Rabin on Instagram Dr. Dave's Book, "A Simple Guide to Being Alive" Episode Sponsors: The Practitioner Certification Program by Third Wave's Psychedelic Coaching Institute. The Microdosing Practitioner Certification at Psychedelic Coaching Institute. Golden Rule - Get a lifetime discount of 10% with code THIRDWAVE at checkout These show links may contain affiliate links. Third Wave receives a small percentage of the product price if you purchase through the above affiliate links. Disclaimer: This content is for educational, informational, and entertainment purposes only. We do not promote or encourage the illegal use of any controlled substances. Nothing said here is medical or legal advice. Always consult a qualified medical or mental health professional before making decisions related to your health. The views expressed herein belong to the speaker alone, and do not reflect the views of any other person, company, or organization. Third Wave occasionally partners with or shares information about other people, companies, and/or providers. While we work hard to only share information about ethical and responsible third parties, we can't and don't control the behavior of, products and services offered by, or the statements made by people, companies, or providers other than Third Wave. Accordingly, we encourage you to research for yourself, and consult a medical, legal, or financial professional before making decisions in those areas. Third Wave isn't responsible for the statements, conduct, services, or products of third parties. If we share a coupon code, we may receive a commission from sales arising from customers who use our coupon code. No one is required to use our coupon codes.

We're getting real today...because building the type of connection that's real and honest takes us looking at love differently. We're joined by John Kim aka The Angry Therapist who challenges the traditional, views of loves, arguing for a more grounded approach that's more realistic. We're discussing the reasons his definition of a healthy relationship has changed over the years, how to co-create with your partner (even if you are on your first date!), and some unconventional advice to connect better, restarting over again, and moving forward after an expired relationship (as he likes to call it).To learn more about John Kim, you can follow him @theangrytherapist and go to https://www.theangrytherapist.com/. Get his new book 'Love Hard On Purpose' wherever books are sold.TW: We do talk about MDMA in this episode----Have you ever had a time in your life where you genuinely didn't want a serious relationship but still wanted connection and chemistry? Download the Fling app in the app store or visit fling.me todayTake our Dating Archetypes quiz: https://howtobedateable.com/Read our book: How To Be Dateable: The Essential Guide To Finding Your Person and Falling in Love: https://howtobedateable.com/Try the Dateable AI Dating Coach: Get personalized advice trained on our years of podcast episodes, courses and frameworks: https://studio.com/dateableFollow us @dateablepodcast, @juliekrafchick and @nonplatonic. Check out our website for more content. Also listen to our other podcasts The Psychology of Relationships and Exit Interview available on Apple Podcasts, Spotify, or wherever you get your podcasts.WE WROTE A BOOK! HOW TO BE DATEABLE (Simon & Schuster) is available now: https://howtobedateable.com/ Have you ever had a time in your life where you genuinely didn't want a serious relationship but still wanted connection and chemistry? Download the Fling app in the app store or visit fling.me today. Want to remove distractions from your dates? Download Brick and get 10% off at https://www.getbrick.app/DATEABLEOur Sponsors:* Avocado Green Mattress: Check out their mattress and furniture sale: https://avocadogreenmattress.com/DATEABLE* Losers Part One and Two by Harley LaRoux: Go get the book wherever books are sold in print or ebook or through https://www.kensingtonbooks.com* Quince: Get free shipping and 365 day returns at https://quince.com/dateable* Ruggable: Get 10% off your first order, sitewide, with promo code DATEABLE at https://ruggable.comAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

Ketamine Therapy, MDMA, Psilocybin, and the Science of Psychedelic Assisted Healing Most people struggling with depression, anxiety, and trauma have never felt safe in their nervous system, and the treatments they have been prescribed are making that worse. This episode breaks down the neuroscience of psychedelic therapy, why ketamine is the safest and most accessible starting point, how MDMA triggers a BDNF dependent pathway that repairs trauma all the way down to the epigenetic code, and why your antidepressant may be blocking the very brain states required for real healing. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR -Order Dr. Rabin's Book ‘A Simple Guide to Being Alive': https://apolloneuro.com/pages/a-simple-guide-to-being-alive Host Dave Asprey sits down with Dr. Dave Rabin, MD, PhD, a senior research scientist at the Florida Institute for Human and Machine Cognition, Executive Director of The Board of Medicine, and co-founder and Chief Medical Officer of Apollo Neuroscience. Dr. Rabin received his MD and PhD in neuroscience from Albany Medical College and specialized in psychiatry at the University of Pittsburgh Medical Center. He has spent 20 years studying chronic stress and non-invasive therapies for treatment-resistant illness, and his primary research on MDMA assisted therapy for severe PTSD has demonstrated that trauma can be reversed at the epigenetic level, offering a genuine path to a cure. His upcoming book A Simple Guide to Being Alive publishes June 1, 2026 and is a science-backed manual for anyone who has ever felt overwhelmed by the modern world. Dave and Dr. Rabin break down why nearly 50% of people prescribed psychiatric medication never achieve remission, why SSRIs and SNRIs physically block the brain states required for emotional healing, and why the FDA rejected MDMA therapy after three trials showed an 88% response rate. They dig into the exact BDNF pathway that makes MDMA and ketamine so transformative, how psychedelics amplify safety learning in the amygdala at the molecular level, and why trauma passes down up to 14 generations through epigenetic code that can now be measured and repaired. They also cover why your breathing rate at the doctor's office is already a stress signal nobody is reading, how your smartphone puts your nervous system into a chronic fear state before you even get out of bed, and why ketamine is the right starting point for anyone curious about psychedelic therapy right now. You'll Learn: Why nearly 50% of psychiatric patients never get better and what treatment-resistant actually means How ketamine therapy works, why it is legal in every state, and why it is the safest place to start The exact BDNF pathway through which MDMA repairs fear extinction in the amygdala How MDMA assisted therapy produces measurable epigenetic repair of the cortisol receptor gene damaged by trauma Why SSRIs and SNRIs block the insula mediated brain states required for real emotional healing Why combining serotonergic psychedelics with SSRIs puts you at risk of life-threatening serotonin syndrome Why trauma passes down up to 14 generations and what you can do to stop the cycle now Why smartphones put your nervous system into a toxic overstimulation state before the day even starts How the FDA rejected MDMA therapy after 88% of patients responded and who paid to make that happen Thank you to our sponsors! - Qualia | If you want to take the guesswork out of maintaining high NAD+ levels as you age, go to www.qualialife.com/daveNAD to get clinically proven Qualia NAD+ backed by a 100 day money back guarantee and code DAVENAD at checkout gets you an extra 15% off. - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE - OneSkin | For a limited time, try OneSkin with 15% off at oneskin.co/DAVE. - LMNT | Right now you can get a free 8-count Sample Pack of LMNT's most popular drink mix flavors with any purchase at drinkLMNT.com/dave Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Dave Rabin, Dr. Dave Rabin, Apollo Neuroscience, A Simple Guide to Being Alive, ketamine therapy, MDMA assisted therapy, psilocybin therapy, psychedelic assisted therapy, treatment-resistant depression, treatment-resistant mental illness, BDNF pathway, fear extinction amygdala, vagus nerve activation, trauma epigenetics, cortisol receptor gene, epigenetic repair, serotonin syndrome, SSRI alternatives, MDMA BDNF, ketamine BDNF, nervous system safety, autonomic nervous system, parasympathetic nervous system, generational trauma, trauma self-trust, MAPS MDMA trial, FDA MDMA rejection, pharmaceutical interference MDMA, breathing rate stress, smartphone nervous system, Apollo Neuro wearable, Board of Medicine, theboardofmedicine.org, insula cortex, psychedelic safety protocol, ketamine legal therapy, MDMA 88 percent, bottom-up learning psychedelics, trauma fractured self-trust, 14 generations trauma, stress breathing range Resources: • Order Dr. Rabin's Book ‘A Simple Guide to Being Alive': https://apolloneuro.com/pages/a-simple-guide-to-being-alive • Purchase Dr. Fotuhi's New Book The Invincible Brain: https://a.co/d/0iHCgPpL • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 01:34 – Dave Rabin Introduction 05:01 – Psychedelics and Psychiatry 08:35 – Psychedelic Safety and Dosing 14:53 – Serotonin Syndrome Warning 21:17 – Vagus Nerve and Safety 27:36 – Smartphones and Chronic Stress 34:18 – Defining Trauma 38:00 – Trauma and Epigenetics 40:23 – MDMA Cortisol Gene Repair 44:44 – Therapy vs. Medicine Alone 49:15 – FDA MDMA Rejection 55:35 – Ketamine Personal Experience 59:15 – Closing and Book Recommendation See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

I've always wondered how specifically having good relationships can decrease our likelihood of cancer or having a heart attack, and improve our immune systems and brain health. Well, I asked a Stanford Neuroscientist and his answers are absolutely fascinating.  Dr. Ben Rein is an award-winning neuroscientist and lecturer at Stanford, and the author of the phenomenal new book, Why Brains Need Friends. We are talking about why hanging out with your friends floods your brain with a chemical cocktail that is basically a microdose of MDMA, why being married beats chemotherapy as the number one predictor of surviving cancer, why Botox and Tylenol and Advil are making it harder to make friends, yes, really, and why we should all probably get dogs and get our parents to get dogs if we want them to live a long time. You're going to come away with a ton of action steps to not only live longer and be healthier, but also just feel better every single day.