Vascular Adviser Podcast

How do new insights from the XARENO study impact treatment options for patients with AF and advanced CKD? In this episode, Dr Manesh Patel and Dr Peter Rossing expand upon the XARENO 2-year outcomes data presented at the ACC 2023 congress. The experts provide cardiology and endocrinology perspectives into how these results add to the wealth of randomized clinical trial and real-world data to determine the treatment options for patients with AF and advanced CKD. The views and opinions expressed throughout this podcast are those of the speakers based on their expertise and do not necessarily reflect those of Bayer. The Bayer product rivaroxaban is discussed during this episode. Rivaroxaban is indicated for the prevention of stroke and systemic embolism in adult patients with non-valvular atrial fibrillation with one or more risk factors, such as congestive heart failure, hypertension, age ≥75 years, diabetes mellitus, prior stroke or transient ischaemic attack. Further details: • The ACC 2023 presentation of the 2-year XARENO data can be accessed here: https://www.abstractsonline.com/pp8/#!/10674/presentation/19112 • The 1-year results from the XARENO study can be found here https://www.ahajournals.org/doi/10.1161/circ.142.suppl_3.13927, here https://www.researchgate.net/profile/Kai-Hahn2/publication/360217368_ACC22_XARENO_Poster_Final/links/6268ee8e8e6d637bd101 b8d0/ACC22-XARENO-Poster-Final.pdf and here https://www.jacc.org/doi/abs/10.1016/S0735-1097%2822%2901192-5 • The XARENO study design is available here: https://journals.viamedica.pl/kardiologia_polska/article/view/86346 • Access the ROCKET AF manuscript here: https://www.nejm.org/doi/full/10.1056/nejmoa1009638 • The 2020 ESC guidelines for AF treatment can be accessed here: https://www.escardio.org/Guidelines/Clinical-Practice-Guidelines/Atrial-FibrillationManagement • AF treatment guidelines published by the AHA/ACC/AHS in 2019 can be found here: 230313-XARENO 2 year outcomes podcast shownotes-draft3 4 https://www.ahajournals.org/doi/10.1161/CIR.0000000000000665 • For anticoagulant dosing information, see the European labels for apixaban (http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_- _Product_Information/human/002148/WC500107728.pdf), dabigatran (http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_- _Product_Information/human/000829/WC500041059.pdf), edoxaban (http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_- _Product_Information/human/002629/WC500189045.pdf), rivaroxaban (https://www.ema.europa.eu/documents/product-information/xarelto-epar-productinformation_en.pdf) and warfarin (https://www.medicines.org.uk/emc/product/3064/smpc) MA-M_RIV-ALL-1368-2 & MA-M_RIV-ALL-1370-2

This podcast is a follow-up to Bayer's symposium at ESC 2022, ‘The beginning of the end for NOACs? The extra mile'. In this episode, Dr Manesh Patel and Professor Rupert Bauersachs expand on the discussions from the symposium, providing further insight into the management of frail patients with AF and VTE. The experts also provide their perspectives on the treatment of paediatric patients with VTE and patients with cancer-associated thrombosis, evaluating the available evidence to guide decision-making for these particularly vulnerable patients. The views and opinions expressed throughout this podcast are those of the speakers based on their expertise and do not necessarily reflect those of Bayer. Further details: • The EINSTEIN programme publications can be found here for EINSTEIN PE (https://www.nejm.org/doi/full/10.1056/NEJMoa1113572), EINSTEIN DVT (https://www.nejm.org/doi/full/10.1056/NEJMoa1007903), EINSTEIN Pooled (https://thrombosisjournal.biomedcentral.com/articles/10.1186/1477-9560-11-21), EINSTEIN CHOICE (https://www.nejm.org/doi/full/10.1056/nejmoa1700518) and EINSTEIN JUNIOR (https://www.thelancet.com/journals/lanhae/article/PIIS2352-3026(19)30219-4/fulltext) • Real-world evidence published by Craig Coleman on the efficacy and safety of rivaroxaban versus warfarin in frail patients with VTE can be accessed here: https://www.amjmed.com/article/S0002-9343(18)30202-X/fulltext • The XALIA study publication can be found here: https://www.thelancet.com/journals/lanhae/article/PIIS2352-3026(15)00257-4/fulltext • The findings from the XANTUS trial are available here: https://academic.oup.com/eurheartj/article/37/14/1145/2466063 • Access the ROCKET AF manuscript here: https://www.nejm.org/doi/full/10.1056/nejmoa1009638 • The elderly subgroup analysis of ROCKET AF can be found here: https://www.ahajournals.org/doi/10.1161/circulationaha.113.005008 • Findings from the SAFIR trial can be accessed here: https://heart.bmj.com/content/107/17/1376 • Find the edoxaban phase II trial paper here: https://www.thieme-connect.com/products/ejournals/abstract/10.1160/TH10-01-0066 • Read the SELECT-D study paper here: https://ascopubs.org/doi/10.1200/JCO.2018.78.8034 • Information on the OSCAR trials can be found here for the UK (https://clinicaltrials.gov/ct2/show/NCT05112666, https://abstracts.isth.org/abstract/comparison-of-effectiveness-and-safety-of-direct-oral-anticoagulant-versus-low-molecular-weight-heparin-treatment-for-venous-thromboembolism-in-patients-with-active-cancer-the-oscar-uk-study/) and the US (https://clinicaltrials.gov/ct2/show/NCT04979780, https://www.sciencedirect.com/science/article/pii/S0006497121040908) • Details on the Mayo Clinic prospective cohort study are available here: https://www.mayoclinicproceedings.org/article/S0025-6196(21)00435-3/fulltext • Support for the proportion of patients not receiving anticoagulation can be accessed here: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278389/#CIT0011 • For anticoagulant dosing information, see the European labels for apixaban (http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/002148/WC500107728.pdf), dabigatran (http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/000829/WC500041059.pdf), edoxaban (http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/002629/WC500189045.pdf), rivaroxaban (https://www.ema.europa.eu/documents/product-information/xarelto-epar-product-information_en.pdf) and warfarin (https://www.medicines.org.uk/emc/product/3064/smpc) Audio: MA-M_RIV-ALL-1236-1 Shownotes: MA-M_RIV-ALL-1237-1

In this episode, Professor Jan Beyer-Westendorf and Professor Rupert Bauersachs discuss the latest real-world evidence for the extended treatment of patients with venous thromboembolism (VTE). They focus on data published from the all-comer Dresden NOAC Registry, which provides important insights on the adherence patterns of patients with VTE on anticoagulation treatment beyond 12 months. Our experts also discuss the FIRST and SWIVTER registries, and how their findings highlight the importance of patient preference in maintaining patient persistence with extended treatment in order for patients to gain the full benefits of their treatment. The views and opinions expressed throughout this podcast are those of the speakers based on their expertise and do not necessarily reflect those of Bayer. • You can read the most up to date CHEST guidelines here: https://journal.chestnet.org/article/S0012-3692(21)01507-5/fulltext • The Dresden NOAC Registry showed high persistence of patients with VTE on rivaroxaban, these results can be viewed here: https://www.thrombosisresearch.com/article/S0049-3848(21)00515-6/fulltext • EINSTEIN CHOICE investigated the extended treatment of VTE patients with rivaroxaban versus aspirin, results from the trial can be found here: https://www.nejm.org/doi/full/10.1056/nejmoa1700518 • The FIRST registry is the largest real-world evidence registry for rivaroxaban to date, read about its findings on treatment adherence here: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8606029/ • Read more about the insights from the SWIVTER registry here: https://www.thiemeconnect.com/products/ejournals/abstract/10.1160/TH16-03-0209 • The EINSTEIN EXTENSION study our experts discuss in this podcast can be found here: https://www.nejm.org/doi/full/10.1056/nejmoa1007903 Extended treatment VTE podcast-draft1 4 • The pooled results from the EINSTEIN PE and EINSTEIN DVT studies are available here: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3850944/ • For anticoagulant dosing information, see the European labels for apixaban (Eliquis) (http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_- _Product_Information/human/002148/WC500107728.pdf), dabigatran (Pradaxa) (http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_- _Product_Information/human/000829/WC500041059.pdf), edoxaban (Lixiana) (http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_- _Product_Information/human/002629/WC500189045.pdf), rivaroxaban (Xarelto) (https://www.ema.europa.eu/documents/product-information/xarelto-epar-productinformation_en.pdf) and warfarin (https://www.medicines.org.uk/emc/product/3064/smpc) Recording approval: PP-XAR-ALL-2638-1 Shownotes approval: PP-XAR-ALL-2639-1

In this podcast, Dr Manesh Patel, Professor Reinhold Kreutz and Dr Andrew Steele discuss the results of the XARENO study and its implications for patients with AF and chronic kidney disease. This group of experts share their insights on how cardiologists and nephrologists can work most effectively together in multi-disciplinary teams to provide optimal care for these patients. The views and opinions expressed throughout this podcast are those of the speakers based on their expertise and do not necessarily reflect those of Bayer AG. Further details: • The paper on the rationale and design of the XARENO study can be found here: https://journals.viamedica.pl/kardiologia_polska/article/view/86346 • The XARENO abstract presented at ACC 2022 is available here: https://www.jacc.org/doi/10.1016/S0735-1097%2822%2901192-5 • The results of XARENO presented at AHA 2020 can be accessed here: https://www.ahajournals.org/doi/10.1161/circ.142.suppl_3.13927 • Further information on the XARENO trial can be found on the clinicaltrials.gov page here: https://clinicaltrials.gov/ct2/show/study/NCT02663076 • The paper on the ANTENNA study can be found here: https://www.sciencedirect.com/science/article/pii/S0167527322001905 • The 2021 ESC guidelines for the diagnosis and management of atrial fibrillation featuring the ABC pathway for AF treatment are available here: https://academic.oup.com/eurheartj/article/42/5/373/5899003 • Find the 2019 AHA/ACC/HRS focused update of the 2014 AHA/ACC/HRS guidelines for the management of patients with atrial fibrillation here: https://www.ahajournals.org/doi/10.1161/CIR.0000000000000665 • The EHRA practical guide on the use of NOACs in patients with atrial fibrillation can be accessed here: https://academic.oup.com/europace/article/23/10/1612/6247378 • For anticoagulant dosing information, see the European labels for apixaban (http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/002148/WC500107728.pdf), dabigatran (http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/000829/WC500041059.pdf), edoxaban (http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/002629/WC500189045.pdf), rivaroxaban (https://www.ema.europa.eu/documents/product-information/xarelto-epar-product-information_en.pdf) and warfarin (https://www.medicines.org.uk/emc/product/3064/smpc) and the Canadian label for rivaroxaban (https://pdf.hres.ca/dpd_pm/00059600.PDF) Shownotes: MA-M_RIV-ALL-1212-1 Recording: MA-M_RIV-ALL-1205-1

In this episode, Professor Jan Beyer-Westendorf and Dr Cecilia Becattini discuss the treatment of vulnerable patients with venous thromboembolism. In particular, they focus on the treatment of patients who have received the devastating diagnosis of pulmonary embolism. Other specific patient groups are also discussed, including patients who are considered vulnerable and therefore carry a significant additional burden, even beyond the heavy load afforded by a VTE diagnosis. These include frail patients, children and those who are also navigating a cancer diagnosis and treatment. Practical guidance for the treatment of these patients is discussed, based upon a hierarchy of risk and the options available to physicians at each point along the spectrum, from intensive care admission to home treatment. The views and opinions expressed throughout this podcast are those of the speakers based on their expertise and do not necessarily reflect those of Bayer. Further details: • Further details on the HoT-PE study of rivaroxaban for the home treatment of PE can be found here: https://academic.oup.com/eurheartj/article/41/4/509/5497670 • Further details on the EINSTEIN-Junior phase III clinical trial of rivaroxaban for the treatment and prevention of VTE in paediatric patients can be found here: https://www.thelancet.com/journals/lanhae/article/PIIS2352-3026(19)30219-4/fulltext • An overview of the CALLISTO program of studies of rivaroxaban in patients with cancer-associated thrombosis can be found here: https://onlinelibrary.wiley.com/doi/10.1002/rth2.12327 • Further details on studies within the CALLISTO program can be found through the following links: – CASSINI: https://www.nejm.org/doi/full/10.1056/NEJMoa1814630 – CASTA-DIVA: https://journal.chestnet.org/article/S0012-3692(21)04079-4/fulltext – SELECT-D: https://ascopubs.org/doi/10.1200/JCO.2018.78.8034 – COSIMO: https://www.thrombosisresearch.com/article/S0049-3848(21)00381-9/fulltext • The 2019 European Society of Cardiology guidelines for the diagnosis and management of acute pulmonary embolism, developed in collaboration with the European Respiratory Society, can be found here: https://academic.oup.com/eurheartj/article-lookup/doi/10.1093/eurheartj/ehz405 • The American College of Chest Physicians guidelines for antithrombotic therapy for VTE disease can be found here: https://journal.chestnet.org/article/S0012-3692(15)00335-9/fulltext • The summary of product characteristics for rivaroxaban can be found here: https://www.medicines.org.uk/emc/product/2793/smpc#gref • The summary of product characteristics for apixaban can be found here: https://www.medicines.org.uk/emc/product/2878/smpc#gref • The summary of product characteristics for edoxaban can be found here: https://www.medicines.org.uk/emc/product/6905/smpc#gref • The summary of product characteristics for dabigatran can be found here: https://www.medicines.org.uk/emc/product/4703/smpc#gref Recording approval code: PP-XAR-ALL-2606 Shownotes approval code: PP-XAR-ALL-2607

This podcast is a follow-up to Bayer's symposium at EHRA 2022 ‘What if? Protecting your patients with AF from stroke, no matter their journey.' In this discussion, Professor John Camm and Professor Keith Fox provide further insight as to why patients with AF undergoing PCI need such close attention when choosing an antithrombotic regimen. They also explore additional considerations for the management of patients with AF undergoing elective PCI. Finally, the experts provide their perspectives on how patients with AF undergoing catheter ablation can be best protected from cardioembolic stroke. The views and opinions expressed throughout this podcast are those of the speakers based on their expertise and do not necessarily reflect those of Bayer. Further details: • Read the 2020 ESC guidelines for the management of atrial fibrillation here: https://academic.oup.com/eurheartj/article/42/5/373/5899003 • The 2020 ESC guidelines for the management of acute coronary syndromes can be found here: https://academic.oup.com/eurheartj/article/42/14/1289/5898842 • Find the 2019 AHA/ACC/HRS focused update of the 2014 AHA/ACC/HRS guidelines for the management of patients with atrial fibrillation here: https://www.ahajournals.org/doi/10.1161/CIR.0000000000000665 • The EHRA practical guide on the use of NOACs in patients with atrial fibrillation can be accessed here: https://academic.oup.com/europace/article/23/10/1612/6247378 • The papers for the trials investigating NOACs in patients with AF undergoing PCI can be found here for rivaroxaban (https://www.nejm.org/doi/full/10.1056/nejmoa1611594), apixaban (https://www.nejm.org/doi/full/10.1056/NEJMoa1817083), edoxaban (https://www.sciencedirect.com/science/article/abs/pii/S0140673619318720) and dabigatran (https://www.nejm.org/doi/full/10.1056/nejmoa1708454) • The findings from the Japanese study of rivaroxaban monotherapy versus rivaroxaban plus clopidogrel, the AFIRE trial, is available here: https://www.nejm.org/doi/full/10.1056/nejmoa1904143 • Data from the COMPASS trial can be accessed here: https://www.nejm.org/doi/full/10.1056/nejmoa1709118 • For anticoagulant dosing information, see the European labels for apixaban (http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_- _Product_Information/human/002148/WC500107728.pdf), dabigatran (http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_- _Product_Information/human/000829/WC500041059.pdf), edoxaban (http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_- _Product_Information/human/002629/WC500189045.pdf), rivaroxaban (https://www.ema.europa.eu/documents/product-information/xarelto-epar-productinformation_en.pdf) and warfarin (https://www.medicines.org.uk/emc/product/3064/smpc) • For antiplatelet dosing information, see the European labels for clopidogrel (https://www.ema.europa.eu/en/documents/product-information/plavix-epar-productinformation_en.pdf), prasugrel (https://www.ema.europa.eu/en/documents/productinformation/efient-epar-product-information_en.pdf) and ticagrelor (https://www.ema.europa.eu/en/documents/product-information/brilique-epar-productinformation_en.pdf) • The European label for pantoprazole can be accessed here: https://www.ema.europa.eu/en/documents/product-information/pantoloc-control-eparproduct-information_en.pdf Show notes: MA-M_RIV-ALL-1173-1 Recording: MA-M_RIV-ALL-1172-1

In this episode, Dr Sonia Anand and Professor Rupert Bauersachs discuss practical perspectives on how vascular surgeons can improve outcomes in patients with symptomatic PAD undergoing peripheral revascularization. Further details: • The results of the COMPASS trial can be found here: https://www.nejm.org/doi/full/10.1056/nejmoa1709118 • A subgroup analysis of patients with PAD in the COMPASS trial can be accessed here: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)32409-1/fulltext • A subanalysis of the COMPASS trial investigating the net clinical benefit of dual pathway inhibition is available here: https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.120.046048 • The findings from the VOYAGER PAD trial can be found here: https://www.nejm.org/doi/full/10.1056/nejmoa2000052 • The study investigating the total ischaemic event reduction with rivaroxaban in VOYAGER PAD can be accessed here: https://www.sciencedirect.com/science/article/pii/S0735109721050166 • A meta-analysis of the COMPASS and VOYAGER trials is available here: https://academic.oup.com/eurjpc/advance-article/doi/10.1093/eurjpc/zwab128/6360030 • More information on the effect of concomitant clopidogrel on the efficacy and safety of rivaroxaban and aspirin in VOYAGER can be found here: https://www.ahajournals.org/doi/full/10.1161/CIRCULATIONAHA.120.050465 • The CASPAR paper can be accessed here: https://www.jvascsurg.org/article/S0741-5214(10)00981-X/fulltext • The Dutch BOA trial paper is available here: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(99)07199-8/fulltext • The summary of product characteristics for rivaroxaban can be found here: https://www.ema.europa.eu/en/documents/product-information/xarelto-epar-product-information_en.pdf • The summary of product characteristics for clopidogrel can be found here: https://www.medicines.org.uk/emc/product/5288/smpc

In this episode, Professor Cihan Ay and Dr Jeffrey Weitz and provide an overview of the evidence base for the use of rivaroxaban in CAT, including randomized controlled clinical trials, real-world studies and data regarding patient satisfaction and quality of life. Further details: • The paper on the CLOT trial investigating the efficacy of dalteparin versus oral anticoagulation in preventing recurrent thrombosis in patients with cancer is available here: https://www.nejm.org/doi/full/10.1056/nejmoa025313 • Papers on the five randomized controlled trials comparing NOACs with dalteparin for the treatment of CAT can be accessed here: SELECT-D and CASTA DIVA with rivaroxaban (https://ascopubs.org/doi/10.1200/JCO.2018.78.8034 and https://journal.chestnet.org/article/S0012-3692(21)04079-4/fulltext), ADAM VTE and Caravaggio with apixaban (https://onlinelibrary.wiley.com/doi/full/10.1111/jth.14662 and https://www.nejm.org/doi/full/10.1056/NEJMoa1915103) and Hokusai VTE Cancer with edoxaban (https://www.nejm.org/doi/full/10.1056/NEJMoa1711948) • Information on the CALLISTO programme can be found here: https://onlinelibrary.wiley.com/doi/10.1002/rth2.12327 • Details on the COSIMO study are available here: https://thrombosisjournal.biomedcentral.com/articles/10.1186/s12959-018-0176-2 and https://ashpublications.org/blood/article/134/Supplement_1/2161/427953/Baseline-Characteristics-and-Clinical-Outcomes • Information on the CONKO-011 study can be accessed here: https://abstracts.isth.org/abstract/improved-patient-reported-treatment-satisfaction-with-rivaroxaban-as-compared-to-low-molecular-weight-heparins-for-cancer-patients-with-acute-venous-thromboembolism-results-from-the-conko-011-trial/ and https://clinicaltrials.gov/ct2/show/NCT02583191 • Study information for the OSCAR studies can be found here for OSCAR-US (https://clinicaltrials.gov/ct2/show/NCT04979780), OSCAR-UK (https://clinicaltrials.gov/ct2/show/NCT05112666) and OSCAR-SE (https://clinicaltrials.gov/ct2/show/NCT05150938) • The abstract of the OSCAR-US presentation at ASH 2021 is available here: https://ash.confex.com/ash/2021/webprogram/Paper151566.html • The American Society of Hematology 2021 guidelines for management of venous thromboembolism: prevention and treatment in patients with cancer guidelines can be accessed here: https://ashpublications.org/bloodadvances/article-lookup/doi/10.1182/bloodadvances.2020003442

This podcast is a follow up to Bayer's symposium at ESC 2021 ‘Evolving Cardiovascular Risk: Your Patient's Past, Present and Future'. Following on from the discussions at that meeting, Professor Craig Coleman and Professor Roxana Mehran provide further expert perspectives on the importance of considering your patient's kidney function when they have atrial fibrillation, and discuss how to protect patients from the devastating effects of stroke. Professor Manesh Patel and Dr Rónán Collins then focus on stroke prevention in older patients with atrial fibrillation and highlight the fascinating studies that caught their eye among the ESC scientific programme. Further details: • Read the 2020 ESC guidelines for the management of atrial fibrillation here: https://www.escardio.org/Guidelines/Clinical-Practice-Guidelines/Atrial-Fibrillation-Management • Find the 2019 AHA/ACC/HRS focused update of the 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation here: https://www.ahajournals.org/doi/10.1161/CIR.0000000000000665 • The EHRA practical guide on the use of NOACs in patients with atrial fibrillation can be accessed here: https://academic.oup.com/europace/article/23/10/1612/6247378 • Real-world evidence from the ANTENNA study showing the benefit of rivaroxaban versus warfarin for the treatment of renal decline in patients with atrial fibrillation is available here: https://esc2021-abstract.medicalcongress.online/mediatheque/media.aspx?channel=103467&mediaId=104597 • The study by Bonand et al. demonstrating the benefits of NOACs versus vitamin-K antagonists in patients older than 80 years with atrial fibrillation can be seen here: https://esc2021-abstract.medicalcongress.online/mediatheque/media.aspx?channel=103467&mediaId=107076 • Data from the EMIR study regarding treatment of elderly patients with atrial fibrillation with rivaroxaban can be seen here: https://esc2021-abstract.medicalcongress.online/mediatheque/media.aspx?channel=103467&mediaId=107122 • The study by Lee et al. confirming the positive net clinical benefits of NOACs in elderly patients with high bleeding risk and atrial fibrillation is available here: https://esc2021-abstract.medicalcongress.online/mediatheque/media.aspx?channel=103467&mediaId=104607 • Data presented by Chao et al. on the impact of off-label dosing of NOACs in elderly patients can be found here: https://esc2021-abstract.medicalcongress.online/mediatheque/media.aspx?channel=103467&mediaId=105312 • Data from the ETNA-AF study can be accessed here: https://esc2021-abstract.medicalcongress.online/mediatheque/media.aspx?channel=103467&mediaId=105275 • The original publication of the ARISTOTLE trial can be found here: https://www.nejm.org/doi/full/10.1056/nejmoa1107039 • Access to the ROCKET AF original publication can be found here: https://www.nejm.org/doi/full/10.1056/nejmoa1009638 • The XANTUS primary publication can be found here: https://academic.oup.com/eurheartj/article/37/14/1145/2466063 • For anticoagulant dosing information, see the European labels for apixaban (http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/002148/WC500107728.pdf), dabigatran (http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/000829/WC500041059.pdf), edoxaban (http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/002629/WC500189045.pdf), rivaroxaban (https://www.ema.europa.eu/documents/product-information/xarelto-epar-product-information_en.pdf) and warfarin (https://www.medicines.org.uk/emc/product/3064/smpc) Show notes: MA-M_RIV-ALL-1126-1 Recording: MA-M_RIV-ALL-1125-1

In this episode, Dr Sonia Anand and Professor Rupert Bauersachs discuss practical perspectives on how vascular surgeons can improve outcomes in patients with symptomatic PAD undergoing peripheral revascularization. Further details: • The results of the COMPASS trial can be found here: https://www.nejm.org/doi/full/10.1056/nejmoa1709118 • A subgroup analysis of patients with PAD in the COMPASS trial can be accessed here: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)32409-1/fulltext • A subanalysis of the COMPASS trial investigating the net clinical benefit of dual pathway inhibition is available here: https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.120.046048 • The findings from the VOYAGER PAD trial can be found here: https://www.nejm.org/doi/full/10.1056/nejmoa2000052 • The study investigating the total ischaemic event reduction with rivaroxaban in VOYAGER PAD can be accessed here: https://www.sciencedirect.com/science/article/pii/S0735109721050166 • A meta-analysis of the COMPASS and VOYAGER trials is available here: https://academic.oup.com/eurjpc/advance-article/doi/10.1093/eurjpc/zwab128/6360030 • More information on the effect of concomitant clopidogrel on the efficacy and safety of rivaroxaban and aspirin in VOYAGER can be found here: https://www.ahajournals.org/doi/full/10.1161/CIRCULATIONAHA.120.050465 • The CASPAR paper can be accessed here: https://www.jvascsurg.org/article/S0741- 5214(10)00981-X/fulltext • The Dutch BOA trial paper is available here: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(99)07199-8/fulltext • The summary of product characteristics for rivaroxaban can be found here: https://www.ema.europa.eu/en/documents/product-information/xarelto-epar-productinformation_en.pdf • The summary of product characteristics for clopidogrel can be found here: https://www.medicines.org.uk/emc/product/5288/smpc Show notes: PP-XAR-ALL-2448-1 Recording: PP-XAR-ALL-2447-1

In this episode, Professor Stavros Konstantinides and Professor Ander Cohen discuss contemporary guidance on how the patient experience can be improved for those receiving non-vitamin K antagonist oral anticoagulants (NOACs) for venous thromboembolism (VTE) without concurrent cancer. Further details: • The 2019 European Society of Cardiology (ESC) guidelines for the diagnosis and management of acute pulmonary embolism, developed in collaboration with the European Respiratory Society (ERS), can be found here: https://academic.oup.com/eurheartj/article-lookup/doi/10.1093/eurheartj/ehz405 • The American College of Chest Physicians (ACCP) guidelines for antithrombotic therapy for VTE disease can be found here: https://journal.chestnet.org/article/S0012-3692(15)00335-9/fulltext • The summary of product characteristics for rivaroxaban can be found here: https://www.medicines.org.uk/emc/product/2793/smpc#gref • The summary of product characteristics for apixaban can be found here: https://www.medicines.org.uk/emc/product/2878/smpc#gref • The summary of product characteristics for dabigatran can be found here: https://www.medicines.org.uk/emc/product/4703/smpc#gref • The summary of product characteristics for edoxaban can be found here: https://www.medicines.org.uk/emc/product/6905#gref

In this episode, Professor Stavros Konstantinides and Professor Ander Cohen discuss practical considerations for how physicians should decide whether to extend anticoagulation at 6 months following the initiation of treatment for venous thromboembolism. Further details: • The EINSTEIN-Extension study on the extended use of rivaroxaban in patients with VTE can be found here: https://www.nejm.org/doi/full/10.1056/NEJMoa1007903 • The AMPLIFY-EXT study on the extended use of apixaban in patients with VTE can be found here: https://www.nejm.org/doi/full/10.1056/nejmoa1207541 • The 2019 European Society of Cardiology (ESC) guidelines for the diagnosis and management of acute pulmonary embolism, developed in collaboration with the European Respiratory Society (ERS), can be found here: https://academic.oup.com/eurheartj/article-lookup/doi/10.1093/eurheartj/ehz405 • The American College of Chest Physicians (ACCP) guidelines for antithrombotic therapy for VTE disease can be found here: https://journal.chestnet.org/article/S0012-3692(15)00335-9/fulltext • The summary of product characteristics for rivaroxaban can be found here: https://www.medicines.org.uk/emc/product/2793/smpc#gref • The summary of product characteristics for apixaban can be found here: https://www.medicines.org.uk/emc/product/2878/smpc#gref

In this episode, Dr Mari Thomas and Professor Jan Beyer-Westendorf discuss practical considerations for how physicians should take patient preference into account when deciding on an anticoagulant for the treatment of cancer-associated thrombosis. Further details: • Information on patient persistence with oral anticoagulant treatment compared with parenteral can be found here: https://onlinelibrary.wiley.com/doi/full/10.1002/rth2.12002 • Details on the COSIMO study can be found here: https://thrombosisjournal.biomedcentral.com/articles/10.1186/s12959-018-0176-2 and https://ashpublications.org/blood/article/134/Supplement_1/2161/427953/Baseline-Characteristics-and-Clinical-Outcomes • The American Society of Hematology 2021 guidelines for management of venous thromboembolism: prevention and treatment in patients with cancer guidelines can be found here: https://ashpublications.org/bloodadvances/article-lookup/doi/10.1182/bloodadvances.2020003442 • The American Society of Clinical Oncology venous thromboembolism prophylaxis and treatment in patients with cancer clinical practice guideline update can be found here: https://ascopubs.org/doi/10.1200/JCO.19.01461?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed • The 2019 International Initiative on Thrombosis and Cancer clinical practice guidelines for the treatment and prophylaxis of venous thromboembolism in patients with cancer can be found here: https://linkinghub.elsevier.com/retrieve/pii/S1470-2045(19)30336-5 • The International Society on Thrombosis and Haemostasis guidelines on the role of direct oral anticoagulants in the treatment of cancer-associated venous thromboembolism can be found here: https://doi.org/10.1111/jth.14219 • The 2019 European Society of Cardiology guidelines for the diagnosis and management of acute pulmonary embolism, developed in collaboration with the European Respiratory Society can be found here: https://academic.oup.com/eurheartj/article-lookup/doi/10.1093/eurheartj/ehz405 Recording approval code: PP-M_RIV-ALL-0195-1; Shownotes approval code: PP-M_RIV-ALL-0196-1

In this episode, Professor Stavros Konstantinides talks about identifying patients with pulmonary embolism who may be candidates for home treatment, Dr David Jimenez explains the results of the HoT-PE study, and Dr Jeff Weitz and Dr Jan Beyer-Westendorf discuss whether a patient with pulmonary embolism could be treated as an outpatient. Further details: • Data on the number of patients with PE who may be suitable for home treatment can be accessed here: https://onlinelibrary.wiley.com/doi/full/10.1111/jth.14423 • Data on the proportion of patients treated as outpatients are available here: https://journals.sagepub.com/doi/10.1177/1076029616674827?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed • The 2019 ESC guidelines on the diagnosis and management of acute PE, developed in collaboration with the ERS, can be found here: https://academic.oup.com/eurheartj/article/41/4/543/5556136 • The 2016 CHEST guidelines on antithrombotic therapy for VTE can be accessed here: https://journal.chestnet.org/article/S0012-3692(15)00335-9/fulltext • The EINSTEIN CHOICE publication can be found here: https://www.nejm.org/doi/full/10.1056/NEJMoa1700518 • The HoT-PE publication is available here: https://academic.oup.com/eurheartj/article/41/4/509/5497670 • The study details of the HOME-PE trial can be found here: https://clinicaltrials.gov/ct2/show/NCT02811237 • The HOME-PE presentation at the 2020 ESC annual meeting can be accessed here by ESC members: https://esc365.escardio.org/Congress/ESC-CONGRESS-2020-The-Digital-Experience/Hot-Line-HOME-PE/224194-home-pe-hospitalisation-or-outpatient-management-of-pe-patients-hestia-vs-simplified-pesi • The meta-analysis by Stefano Barco et al. is available here: https://academic.oup.com/eurheartj/article/40/11/902/5263773 • For anticoagulant dosing information, see the European labels for apixaban (https://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/002148/WC500107728.pdf), dabigatran (https://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/000829/WC500041059.pdf), edoxaban (https://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/002629/WC500189045.pdf), rivaroxaban (https://www.ema.europa.eu/documents/product-information/xarelto-epar-product-information_en.pdf), warfarin (https://www.medicines.org.uk/emc/product/3064/smpc) and low molecular weight heparin (https://www.ema.europa.eu/documents/product-information/inhixa-epar-product-information_en.pdf) (https://www.ema.europa.eu/documents/product-information/arixtra-epar-product-information_en-1.pdf) (https://www.medicines.org.uk/emc/product/4247/smpc#gref) (https://www.medicines.org.uk/emc/product/1695#gref) Recording approval code: PP-M_RIV-ALL-0161-1 Shownotes approval code: PP-M_RIV-ALL-0162-1

In this episode, Dr Alok Khorana talks about the evolution of treatment for patients with cancer-associated thrombosis, Dr Ander Cohen discusses the importance of treatment satisfaction in these patients and Dr Jeff Weitz and Dr Jan Beyer-Westendorf discuss the management of a patient with colorectal cancer and incidental pulmonary embolism Further Details: • Data showing the increased risk of VTE recurrence in patients with cancer-associated thrombosis is available here: https://ashpublications.org/blood/article/100/10/3484/106282/Recurrent-venous-thromboembolism-and-bleeding • The dedicated trials on NOACs in cancer-associated thrombosis can be accessed here for edoxaban (https://pubmed.ncbi.nlm.nih.gov/31733403/), rivaroxaban (https://pubmed.ncbi.nlm.nih.gov/31995662/) and apixaban (https://pubmed.ncbi.nlm.nih.gov/28837207/, https://pubmed.ncbi.nlm.nih.gov/32223112/) • More details on the patient reported outcomes in COSIMO can be found here: https://pubmed.ncbi.nlm.nih.gov/32877956/ • COSIMO baseline characteristics and clinical outcomes are described here: https://ashpublications.org/blood/article/134/Supplement_1/2161/427953/Baseline-Characteristics-and-Clinical-Outcomes • The ISTH 2018 guidelines on cancer-associated thrombosis can be found here: https://onlinelibrary.wiley.com/doi/full/10.1111/jth.14219 • The ASCO 2019 guidelines on cancer-associated thrombosis can be found here: https://ascopubs.org/doi/10.1200/JCO.19.01461 • The ITAC 2019 guidelines on cancer-associated thrombosis can be found here: https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(19)30336-5/fulltext • The NCCN 2020 guidelines on cancer-associated thrombosis can be found here: https://www.google.com/url?client=internal-element-cse&cx=007894372670309631110:vocdaeamxuy&q=https://www.nccn.org/Common/FileManager.ashx%3FfileManagerId%3Db0461271-ae6f-455a-bbb9-a637326abe49&sa=U&ved=2ahUKEwiTm5-0kcvsAhWNqZ4KHZinDsMQFjAAegQIBhAB&usg=AOvVaw1lR7Ua6h1mBxVItb_BHMe9 • The ESC 2019 guidelines on the diagnosis and management of acute pulmonary embolism can be found here: https://academic.oup.com/eurheartj/article/41/4/543/5556136 • For anticoagulant dosing information, see the European labels for apixaban (http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/002148/WC500107728.pdf), dabigatran (http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/000829/WC500041059.pdf), edoxaban (http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/002629/WC500189045.pdf), rivaroxaban (https://www.ema.europa.eu/documents/product-information/xarelto-epar-product-information_en.pdf) and low molecular weight heparin (https://www.ema.europa.eu/documents/product-information/inhixa-epar-product-information_en.pdf) (https://www.ema.europa.eu/documents/product-information/arixtra-epar-product-information_en-1.pdf) (https://www.medicines.org.uk/emc/product/4247/smpc#gref) (https://www.medicines.org.uk/emc/product/1695#gref) Recording approval code: PP-M_RIV-ALL-0157-1; Shownotes approval code: PP-M_RIV-ALL-0158-1

In this episode, Professor Stavros Konstantinides talks about the prevention of recurrent events in patients with venous thromboembolism, Dr Phil Wells explains the pooled analysis of EINSTEIN EXT and EINSTEIN CHOICE and what it tells us about which patients are suitable for extended anticoagulation and Dr Jeff Weitz and Dr Jan Beyer-Westendorf discuss whether a patient treated for pulmonary embolism would be a candidate for extended anticoagulation. Further details: • Data on the risk of recurrent VTE after the discontinuation of anticoagulation therapy can be accessed here: https://haematologica.org/article/view/4325 • The 2019 ESC guidelines on the diagnosis and management of acute pulmonary embolism developed in collaboration with the ERS can be found here: https://academic.oup.com/eurheartj/article/41/4/543/5556136 • The pooled analysis of EINSTEIN CHOICE and EINSTEIN EXTENSION is available here: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5894264/ • The EINSTEIN CHOICE paper can be found here: https://www.nejm.org/doi/full/10.1056/NEJMoa1700518 • The EINSTEIN EXTENSION paper can be accessed here: https://www.nejm.org/doi/10.1056/NEJMoa1007903?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed • Data showing the increased case fatality rate of PE compared with DVT can be found in this publication: https://onlinelibrary.wiley.com/doi/full/10.1111/j.1538-7836.2007.02450.x • Data on the increased risk of VTE recurrence in males versus females can be found here: https://www.bmj.com/content/342/bmj.d813#:~:text=Conclusions-,In%20patients%20with%20a%20first%20unprovoked%20venous%20thromboembolism%2C%20men%20have,had%20hormone%20associated%20venous%20thromboembolism. • Data supporting the increased risk of PE versus DVT recurrence in a patient with a previous PE can be found in this publication: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4544622/#:~:text=However%2C%20PE%20patients%20are%20three,be%20low%20in%20these%20patients. • For anticoagulant dosing information, see the European labels for apixaban (http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/002148/WC500107728.pdf), dabigatran (http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/000829/WC500041059.pdf), edoxaban (http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/002629/WC500189045.pdf), rivaroxaban (https://www.ema.europa.eu/documents/product-information/xarelto-epar-product-information_en.pdf) and warfarin (https://www.medicines.org.uk/emc/product/3064/smpc) Recording approval code: PP-M_RIV-ALL-0159-1; Shownotes approval code: PP-M_RIV-ALL-0160-1

Episode Description: Dr Yassir Javaid talks to Thrombosis Adviser about patients with atrial fibrillation and diabetes. Recording approval code: PP-XAR-ALL-1881-1; Metadata approval code: PP-M_RIV-ALL-0114-1

In this episode, Dr Rónán Collins talks about the links between atrial fibrillation and renal impairment, Dr Hendrik Bonnemeier takes us through the RELOADED study and Dr Manesh Patel and Dr Christian Ruff discuss the management of an patient with atrial fibrillation, diabetes and renal impairment. Further Details: •The 2018 EHRA Practical Guide on the use of NOACs in patients with atrial fibrillation can be found here https://academic.oup.com/eurheartj/article/39/16/1330/4942493 •The meta-analysis of the phase III trials of NOACs by Ruff et al. is available here https://pubmed.ncbi.nlm.nih.gov/24315724/ •Recent presentations of data from RELOADED can be found here (https://esc365.escardio.org/vgn-ext-templating/Congress/ESC-CONGRESS-2019/Poster-Session-5-Atrial-fibrillation-and-oral-anticoagulation-6/199357-comparative-safety-of-factor-xa-inhibitors-vs-phenprocoumon-in-patients-with-non-valvular-atrial-fibrillation-and-renal-disease-insights-from-the-reloaded-study#slide) and here (https://esc365.escardio.org/Congress/ESC-CONGRESS-2019/Poster-Session-5-Atrial-fibrillation-and-oral-anticoagulation-1/199283-renal-function-worsening-in-factor-xa-inhibitors-vs-phenprocoumon-in-patients-with-non-valvular-atrial-fibrillation-and-renal-disease-insights-from-the-reloaded-study) and RELOAD is published here (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6510975/). •Thrombosis Adviser's coverage of ESC 2019 is here (https://www.thrombosisadviser.com/esc-spaf/) •The 2019 American Heart Association/American College of Cardiology/Heart Rhythm Society Focused Update of the Guideline for the Management of Patients With Atrial Fibrillation is available here https://www.ncbi.nlm.nih.gov/pubmed/3070343 •The European Society of Cardiology Guidelines for the Management of Atrial Fibrillation can be read here https://www.ncbi.nlm.nih.gov/pubmed/16531986 •For anticoagulant dosing information see the European labels for apixaban (http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/002148/WC500107728.pdf), dabigatran (http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/000829/WC500041059.pdf), edoxaban (http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/002629/WC500189045.pdf), rivaroxaban (https://www.ema.europa.eu/documents/product-information/xarelto-epar-product-information_en.pdf) and warfarin (https://www.medicines.org.uk/emc/product/3064/smpc) Recording approval code: PP-XAR-ALL-1963-1; Shownotes approval code: PP-M_RIV-ALL-0127-1

In this episode, Professor Peter Rossing talks about the links between atrial fibrillation and diabetes, Professor Craig Coleman takes us through the RIVAL study and Dr Manesh Patel and Dr Christian Ruff discuss the management of an obese patient with atrial fibrillation and diabetes. Further Details: Details on the affect that diabetes has on stroke risk in patients with atrial fibrillation can be found on our page on Thrombosis Adviser (https://www.thrombosisadviser.com/diabetes). Data showing how diabetes doubles the rate of renal decline over 2 years are available in this publication (https://www.ncbi.nlm.nih.gov/pubmed/27073197) Full results of the RIVAL study are presented here (https://pubmed.ncbi.nlm.nih.gov/31392894/) Subanalyses of the ROCKET AF trial that look at the effect of rivaroxaban on atherosclerotic events in patients with atrial fibrillation can be seen here (https://pubmed.ncbi.nlm.nih.gov/24132190/) (for coronary events) and here (https://pubmed.ncbi.nlm.nih.gov/24302273/) for limb events The MarketScan analysis looking at major cardiovascular or limb events in patients with atrial fibrillation and diabetes are published here (https://dom-pubs.onlinelibrary.wiley.com/doi/abs/10.1111/dom.13787) The 2019 American Heart Association/American College of Cardiology/Heart Rhythm Society Focused Update of the Guideline for the Management of Patients With Atrial Fibrillation is available here (https://www.ncbi.nlm.nih.gov/pubmed/30703431) More information on COMPASS and VOYAGER PAD can be found on VascularAdviser.com (https://www.thrombosisadviser.com/en/vascular-protection/) The European Society of Cardiology Guidelines for the Management of Atrial Fibrillation can be read here (https://www.ncbi.nlm.nih.gov/pubmed/16531986) For anticoagulant dosing information see the European labels for apixaban (http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/002148/WC500107728.pdf), dabigatran (http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/000829/WC500041059.pdf), edoxaban (http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/002629/WC500189045.pdf), rivaroxaban (https://www.ema.europa.eu/documents/product-information/xarelto-epar-product-information_en.pdf) and warfarin (https://www.medicines.org.uk/emc/product/3064/smpc) Recording approval code: PP-XAR-ALL-1885-1; Shownotes approval code: PP-M_RIV-ALL-0111-1

In this episode, Dr Yassir Javaid gives us his advice on getting to know your patients with atrial fibrillation and diabetes , Professor Craig Coleman explains the results of the CALLIPER study and Dr Manesh Patel and Dr Christian Ruff look at the issues surrounding stroke prevention in an older patient with renal impairment and tell us how COVID-19 is affecting the treatment of patients with cardiovascular disease. Further Details • For more information on the number of strokes that can be prevented click here https://eiuperspectives.economist.com/healthcare/policy-approaches-stroke-prevention/white-paper/preventing-stroke-uneven-progress • Details on the number of patients of atrial fibrillation and comorbid diabetes can be found on our page on Thrombosis Adviser https://www.thrombosisadviser.com/diabetes • Data showing how diabetes doubles the rate of renal decline over 2 years are available in this publication https://pubmed.ncbi.nlm.nih.gov/27073197/ • Full results of the CALLIPER study are presented here https://academic.oup.com/eurheartj/article-abstract/40/Supplement_1/ehz745.1122/5596296?redirectedFrom=fulltext • The 2019 American Heart Association/American College of Cardiology/Heart Rhythm Society Focused Update of the Guideline for the Management of Patients With Atrial Fibrillation is available here • The European Society of Cardiology Guidelines for the Management of Atrial Fibrillation can be read here https://pubmed.ncbi.nlm.nih.gov/16531986/ • For anticoagulant dosing information see the European labels for apixaban (https://www.ema.europa.eu/en/documents/product-information/eliquis-epar-product-information_en.pdf ), dabigatran (https://www.ema.europa.eu/en/documents/product-information/pradaxa-epar-product-information_en.pdf), edoxaban (https://www.ema.europa.eu/en/documents/product-information/lixiana-epar-product-information_en.pdf), rivaroxaban (https://www.ema.europa.eu/en/documents/product-information/xarelto-epar-product-information_en.pdf) and warfarin (https://www.medicines.org.uk/emc/product/3064/smpc) Recording approval code: PP-XAR-ALL-1800-1; Shownotes approval code: PP-M_RIV-ALL-0113-1

Welcome to the Thrombosis Adviser podcast series in which renowned experts in the field of thromboembolic disease join us to discuss key medical issues, offer their views and professional analysis on recent studies, and provide you with practical information on thrombosis management. Recent real-world evidence, as well as results from Phase 3 trials, have shed light on the efficacy and safety of NOACs for the treatment of VTE in different patient populations. My name is James Rudd and in this episode of the Thrombosis Adviser podcast series I am delighted to welcome Ander Cohen – Vascular Physician and Epidemiologist at Guy's and St Thomas' NHS Foundation Trust in London – to discuss practical considerations for the use of NOACs in the treatment of patients with VTE. Approval number: PP-XAR-ALL-1570-1

Welcome to Thrombosis Adviser podcast series in which renowned experts in the field of thromboembolic disease join us to discuss key medical issues, offer their views and professional analysis on recent studies, and provide you with practical information on thrombosis management. Despite current optimised medical treatment, patients with CAD or PAD remain at high risk of cardiovascular events. With the European approval of rivaroxaban vascular dose, 2.5 mg twice daily, plus aspirin, and new European guidelines' recommendations on vascular protection, we are in exciting times. Join James Rudd in this episode of the Thrombosis Adviser Podcast series discussing together with Keith Fox - Professor of Cardiology at the University of Edinburgh - how to interpret the ESC 2019 Guidelines on Chronic Coronary Syndrome. Approval No. PP-XAR-ALL-1571-1