Podcasts about z39

In this episode, we discussed the management of systemic mastocytosis with Dr. Daniel DeAngelo from the Dana Farber Cancer Institute. Here are the key studies we discussed:Midostaurin https://www.nejm.org/doi/10.1056/NEJMoa1513098?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200www.ncbi.nlm.nih.govAvapritinibEXLPORER study: https://www.nature.com/articles/s41591-021-01538-9PATHFINDER study: https://www.nature.com/articles/s41591-021-01539-8Bezuclastinib: APEX trial: https://ashpublications.org/blood/article/144/Supplement%201/659/530240/Apex-Part-1-Updated-Assessment-of-BezuclastinibHSCT for Advanced SM: https://ascopubs.org/doi/10.1200/JCO.2014.55.2018

Dr. Ezra Schwartz (@ezraschwartz10) interviews Dr. Firas Moussa and Mr. Jake Howitt to discuss the IMPROVE-AD Trial, a landmark, multi-institutional study investigating treatment strategies for uncomplicated Type B Aortic Dissection (uTBAD). The IMPROVE-AD Trial is a multicenter randomized trial funded by the NIH/NHLBI that compares thoracic endovascular aortic repair (TEVAR) plus optimal medical therapy (OMT) vs. OMT and surveillance with selective TEVAR in patients with uncomplicated TBAD. The trial aims to address critical gaps in evidence left by prior studies (INSTEAD-XL, ADSORB), with a unique focus on quality of life, cost-effectiveness, and genetic data. Dr. Firas Mussa is a professor and the Chief of Vascular and Endovascular Surgery at McGovern Medical School at UTHealth Houston. He previously served as the Director of the Vascular Surgery Residency and Fellowship programs at NYU Langone Health. Dr. Mussa earned his medical degree from the University of Baghdad, followed by general surgery training at Johns Hopkins University and a vascular surgery fellowship at Baylor College of Medicine. His research focuses on complex aortic pathology, and he serves as the principal investigator of the IMPROVE AD trial. Mr. Jake Howitt is the Community Engagement Co-Chair of the IMPROVE AD trial and a leading patient advocate within the PCORI-funded Aortic Dissection Collaborative. As a survivor of aortic dissection, he is passionate about improving patient-provider communication and raising awareness of hereditary aortic disease. His work emphasizes the importance of education, empathy, and community-building in clinical research and care delivery. Special thank you to Jacob Soucy (@JacobWSoucy). Resources: ·       Treatment of Uncomplicated Type B Aortic Dissection: Optimal Medical Therapy vs TEVAR + Optimal Medical Therapy- https://journals.sagepub.com/doi/10.1177/15385744231184671?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed  ·       INSTEAD Trial - https://pubmed.ncbi.nlm.nih.gov/19996018/ ·       INSTEAD-XL 5-Year Follow-Up - https://pubmed.ncbi.nlm.nih.gov/23922146/ ·       ADSORB Trial - https://pubmed.ncbi.nlm.nih.gov/24962744/ ·       Feasibility of a proposed randomized trial in patients with uncomplicated descending thoracic aortic dissection: Results of worldwide survey - https://pubmed.ncbi.nlm.nih.gov/27823685/ ·       Treatment of AD: Meta-Analysis - https://pubmed.ncbi.nlm.nih.gov/29066151/ ·       TEVAR vs Medical Therapy- https://pubmed.ncbi.nlm.nih.gov/36334259/ ·       IMPROVE AD Trial website - https://improvead.org ·       John Ritter Foundation for Aortic Health - https://johnritterfoundation.org ·       Think Aorta US - https://thinkaorta.us   Follow us @audiblebleeding Learn more about us at https://www.audiblebleeding.com/about-1/ and provide us with your feedback with our listener survey.  *Gore is a financial sponsor of this podcast, which has been independently developed by the presenters and does not constitute medical advice from Gore. Always consult the Instructions for Use (IFU) prior to using any medical device.      

The OncoAlertWeekly Round Up   Covering the TOP of the week April 18-24, 2025  REGISTER at http://OncoAlert360.com OR https://oncoalert.m-pages.com/nhMpwe/oncoalert-newsletter-registration   Discussing:UPDATE on DESTINY-Breast09https://astrazeneca.com/media-centre/press-releases/2025/enhertu-combination-improved-pfs-in-1l-her-positive-mbc.htmlUPDATE on ASCENT 04https://gilead.com/news/news-details/2025/trodelvy-plus-keytruda-demonstrates-a-statistically-significant-and-clinically-meaningful-improvement-in-progression-free-survival-in-patients-with-previously-untreated-pd-l1-metastatic-tripAnnual Report to the Nationon the Status of Cancer, featuring state-level statistics after the onset of the COVID-19 pandemichttps://acsjournals.onlinelibrary.wiley.com/doi/full/10.1002/cncr.35833Osimertinib vs. Afatinib in 1L therapy of atypical EGFR-mutated metastatic non-small cell lung cancer https://lungcancerjournal.info/article/S0169-5002(25)00443-X/fulltextTargeting Lung Cancer with Precision: The ADC Therapeutic Revolutionhttps://link.springer.com/article/10.1007/s11912-025-01655-5Prevalence by therapy line and incidence of breast cancer brain metastases in 18 075 patientshttps://academic.oup.com/jnci/advance-article-abstract/doi/10.1093/jnci/djaf048/8101485?login=falseEuropean screening platform for EORTC clinical trials in advanced colorectal cancer ‘SPECTAcolor'https://esmogastro.org/article/S2949-8198(25)00037-8/fulltextKorea, Japan, Europe, and the United States: Why are guidelines for gastric cancer different?https://link.springer.com/article/10.1007/s10120-025-01613-xOutpatient Administration of Chimeric Antigen Receptor T-Cell Therapy Using Remote Patient Monitoringhttps://ascopubs.org/doi/10.1200/OP-25-00062Safety and Activity of Fibroblast Growth Factor Receptor Inhibitors in Advanced Malignancieshttps://ascopubs.org/doi/10.1200/PO-24-00896?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed

Only 5–10% of cancers are inherited. The rest? Largely driven by diet, toxins, metabolism, and lifestyle. In this powerful episode, Dr. Josh Axe unpacks the real root causes of cancer and shares miraculous healing stories—including his mom, Tammy Peterson, Jordan Rubin, and others who beat the odds with natural and faith-based therapies. Discover the science, strategies, and spiritual truths that challenge the conventional cancer narrative. You'll Learn: What really causes cancer (hint: it's not just DNA) How fasting, keto, and oxygen therapies helped reverse aggressive diagnoses The best diets for fighting and preventing cancer Top anti-cancer herbs, supplements, and therapies Why faith and emotional healing are crucial to recovery This episode will open your eyes to the healing potential of holistic medicine, metabolic science, and spiritual hope. Whether you're facing illness or want to prevent it, you'll walk away empowered and equipped. #cancer #naturalhealth #draxe ------  Want more of The Dr. Josh Axe Show? Subscribe to the YouTube channel. Follow Dr. Josh Axe Instagram Twitter Facebook TikTok Website ------  Staying healthy in today's world is an upstream battle. Subscribe to Wellness Weekly, your 5-minute dose of sound health advice to help you grow physically, mentally, and spiritually. Every Wednesday, you'll get:  Holistic health news & life-hacks from a biblical worldview Powerful free resources including classes, Q&As, and guides from Dr. Axe The latest episodes of The Dr. Josh Axe Show Submit your questions via voice memo to be featured on the show → speakpipe.com/drjoshaxe  ------  Links:  https://www.cancer.gov/about-cancer/causes-prevention/genetics/genetic-testing-fact-sheet https://link.springer.com/article/10.1007/s11095-008-9661-9 https://pubmed.ncbi.nlm.nih.gov/24403443/ https://www.cancerresearchuk.org/about-cancer/treatment/complementary-alternative-therapies/individual-therapies/budwig-diet https://pubmed.ncbi.nlm.nih.gov/20361473/ https://www.ncbi.nlm.nih.gov/books/NBK65971/ https://pmc.ncbi.nlm.nih.gov/articles/PMC9530862/ https://www.mdpi.com/1467-3045/43/2/42 https://journals.lww.com/eurjcancerprev/abstract/9900/the_effects_of_the_ketogenic_diet_on_cancer.175.aspx https://www.mdpi.com/2075-4426/14/9/929 https://pmc.ncbi.nlm.nih.gov/articles/PMC9750928/ https://pubmed.ncbi.nlm.nih.gov/35334103/ https://www.mdpi.com/1422-0067/23/18/10502 https://pmc.ncbi.nlm.nih.gov/articles/PMC10183216/ https://www.tandfonline.com/doi/10.1080/01635581.2023.2274135?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed https://www.sciencedirect.com/science/article/abs/pii/S0304419X20302134?via%3Dihub https://pmc.ncbi.nlm.nih.gov/articles/PMC7793079/ https://pubmed.ncbi.nlm.nih.gov/37054849/ https://pubmed.ncbi.nlm.nih.gov/35457200/ https://pmc.ncbi.nlm.nih.gov/articles/PMC4618242/ https://pubmed.ncbi.nlm.nih.gov/32211937/ https://pubmed.ncbi.nlm.nih.gov/36674232/ https://pubmed.ncbi.nlm.nih.gov/34103583/ https://www.sciencedirect.com/science/article/abs/pii/S1040842819300885?via%3Dihub https://acsjournals.onlinelibrary.wiley.com/doi/10.3322/caac.21818 https://pmc.ncbi.nlm.nih.gov/articles/PMC9278815/ https://pubmed.ncbi.nlm.nih.gov/38473720/ ------  Ads:  Even if your bloodwork looks "normal," your symptoms could point to Cell Danger Response (CDR). Discover how to break free from CDR and unlock your full potential at https://beyondbloodwork.com/. 

Are your cells running low on energy? Fatigue, brain fog, and premature aging often trace back to one root issue: poor mitochondrial function. These tiny power plants inside your cells are responsible for producing the energy your body needs to thrive—and when they're weak, everything suffers. In this episode, Dr. Axe shares the top 10 ways to improve mitochondrial health so you can boost energy, sharpen focus, and slow the aging process—naturally. In this episode, you'll learn: Why mitochondria are essential for energy, brain health, and longevity Signs of mitochondrial dysfunction and how to spot them early The best foods, supplements, and peptides to support mitochondrial repair Top lifestyle therapies that enhance ATP production How toxins, stress, and poor sleep damage your mitochondria—and how to fix it If you're tired of feeling tired, this episode will help you recharge at the cellular level. #cellularhealth #mitochondria #naturalhealth #draxe ------  Want more of The Dr. Josh Axe Show? Subscribe to the YouTube channel. Follow Dr. Josh Axe Instagram Twitter Facebook TikTok Website ------  Staying healthy in today's world is an upstream battle. Subscribe to Wellness Weekly, your 5-minute dose of sound health advice to help you grow physically, mentally, and spiritually. Every Wednesday, you'll get:  Holistic health news & life-hacks from a biblical world view Powerful free resources including classes, Q&As, and guides from Dr. Axe The latest episodes of The Dr. Josh Axe Show Submit your questions via voice memo to be featured on the show → speakpipe.com/drjoshaxe  ------  Links:  https://pmc.ncbi.nlm.nih.gov/articles/PMC10779395/ https://pmc.ncbi.nlm.nih.gov/articles/PMC7392668/ https://pmc.ncbi.nlm.nih.gov/articles/PMC10541842/ https://pubmed.ncbi.nlm.nih.gov/18708297/ https://pmc.ncbi.nlm.nih.gov/articles/PMC11273532/ https://pmc.ncbi.nlm.nih.gov/articles/PMC9729331/ https://www.sciencedirect.com/science/article/pii/S0531556523000864?via%3Dihub https://pubmed.ncbi.nlm.nih.gov/36091835/ https://pmc.ncbi.nlm.nih.gov/articles/PMC9512238/ https://ods.od.nih.gov/factsheets/Carnitine-HealthProfessional/ https://pmc.ncbi.nlm.nih.gov/articles/PMC8234027/ https://pubmed.ncbi.nlm.nih.gov/32776825/ https://pubmed.ncbi.nlm.nih.gov/32554501/ https://pmc.ncbi.nlm.nih.gov/articles/PMC8504390/ https://pmc.ncbi.nlm.nih.gov/articles/PMC8793015/ https://pmc.ncbi.nlm.nih.gov/articles/PMC5407969/ https://journals.physiology.org/doi/full/10.1152/physiol.00038.2018?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org https://pmc.ncbi.nlm.nih.gov/articles/PMC5423095/ https://pmc.ncbi.nlm.nih.gov/articles/PMC11377238/ https://pubmed.ncbi.nlm.nih.gov/34944468/ https://pmc.ncbi.nlm.nih.gov/articles/PMC9518606/ https://pmc.ncbi.nlm.nih.gov/articles/PMC10989710/ https://pmc.ncbi.nlm.nih.gov/articles/PMC5483482/ https://pmc.ncbi.nlm.nih.gov/articles/PMC10380951/ https://pmc.ncbi.nlm.nih.gov/articles/PMC11139944/ https://nyaspubs.onlinelibrary.wiley.com/doi/10.1111/nyas.12998 https://pmc.ncbi.nlm.nih.gov/articles/PMC9601556/ https://pmc.ncbi.nlm.nih.gov/articles/PMC10057714/  ------  Ads:  Even if your bloodwork looks "normal," your symptoms could point to Cell Danger Response (CDR). Discover how to break free from CDR and unlock your full potential at https://beyondbloodwork.com/. 

In this video, Dr. Doug Lucas discusses the use of Evenity (Romosozumab) in treating osteoporosis, highlighting its mechanism of action, efficacy, and safety concerns. He reviews clinical trial data, including the FRAME, ARCH, and STRUCTURE studies, to illustrate the drug's impact on bone density and fracture risk. Dr. Doug emphasizes the importance of understanding both relative and absolute risk reductions, as well as the cardiovascular risks associated with Evenity. He concludes with practical recommendations for its use in clinical practice, stressing the need for careful patient assessment.*STUDIES*https://www.nejm.org/doi/10.1056/NEJMoa1607948?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200www.ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/28892457/https://pubmed.ncbi.nlm.nih.gov/28755782/https://academic.oup.com/jbmr/article-abstract/35/5/994/7500032?redirectedFrom=fulltext&login=false

In this groundbreaking episode of the Dr. Josh Axe Show, we dive deep into the fascinating world of colloidal silver - a natural mineral supplement with extraordinary antimicrobial properties that could revolutionize how we fight infections. Key Takeaways:  Discover how silver ions can penetrate and destroy harmful bacteria at the cellular level Learn about silver's historical medical uses, from wound care to surgical applications Uncover the scientific mechanisms behind colloidal silver's powerful antimicrobial effects Explore cutting-edge research on silver's potential to combat antibiotic-resistant bacteria Tips on safe dosage and application for different health conditions Tune in to unlock nature's hidden antimicrobial secret! You'll walk away with a comprehensive understanding of how this ancient mineral can support your immune system, fight infections, and potentially offer a natural alternative to traditional antibiotics. Whether you're a health enthusiast, looking for holistic wellness strategies, or simply curious about natural healing, this episode is your ultimate guide to harnessing the power of colloidal silver. #naturalhealing #colloidalsilver #alternativemedicine Want more of The Dr. Josh Axe Show? Subscribe to the YouTube channel. Follow Dr. Josh Axe Instagram Twitter Facebook TikTok Website ------  Staying healthy in today's world is an upstream battle. Subscribe to Wellness Weekly, your 5-minute dose of sound health advice to help you grow physically, mentally, and spiritually. Every Wednesday, you'll get: Holistic health news & life-hacks from a biblical world view Powerful free resources including classes, Q&As, and guides from Dr. Axe The latest episodes of The Dr. Josh Axe Show Submit your questions via voice memo to be featured on the show → speakpipe.com/drjoshaxe  ------  Links:  https://karger.com/books/book/2547/chapter-abstract/5742863/Silver-in-Health-Care-Antimicrobial-Effects-and?redirectedFrom=fulltext https://pmc.ncbi.nlm.nih.gov/articles/PMC6315945/ https://pubmed.ncbi.nlm.nih.gov/31963769/ https://www.liebertpub.com/doi/10.1089/acm.2011.0681?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed https://www.nature.com/articles/s41598-023-36460-2 https://pmc.ncbi.nlm.nih.gov/articles/PMC10393856/ https://www.nccih.nih.gov/health/colloidal-silver-what-you-need-to-know https://www.mayoclinic.org/healthy-lifestyle/consumer-health/expert-answers/colloidal-silver/faq-20058061  ------  Ads:  Even if your bloodwork looks "normal," your symptoms could point to Cell Danger Response (CDR). Discover how to break free from CDR and unlock your full potential at https://beyondbloodwork.com. Visit https://www.soltechealth.com to learn more and save $100 off your purchase using the code AXE. Experience the difference for yourself with a 60-day risk free trial. Soltec Health—Rest, Recover, Rejuvenate. Visit silverbiotics.com to check out my favorite colloidal silver product on the market. Make sure to use code AXE at checkout for 30% off your first purchase!

In this episode, we discuss the history of venetoclax in AML, along with key clinical trials that have shaped its current use in AML. Here are the trials discussed in this episode: 1. VIALE-A study: https://www.nejm.org/doi/full/10.1056/NEJMoa20129712. 10 day Decitabine plus venetoclax for ND AML https://www.thelancet.com/journals/lanhae/article/PIIS2352-3026(20)30210-6/abstract3. Genetic Risk Stratification and Outcomes with AML treated with venetoclax and azacitidine https://ashpublications-org.proxy.library.vanderbilt.edu/blood/article/doi/10.1182/blood.2024024944/517355/Genetic-Risk-Stratification-and-Outcomes-Among4. Genetic risk classification for adults with AML receiving less-intensive therapies: the 2024 ELN recommendations https://ashpublications-org.proxy.library.vanderbilt.edu/blood/article/doi/10.1182/blood.2024025409/517356/Genetic-risk-classification-for-adults-with-AML5. AGILE study: Ivosidenib and azacitidine in IDH1-mutated AML https://www.nejm.org/doi/full/10.1056/NEJMoa21173446. MRD response and prognosis in treatment naïve AML with AZA/VEN https://ascopubs.org/doi/10.1200/JCO.21.01546?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed7. Monocytic subclone confer resistance to venetoclax-based therapy in patients with AML https://aacrjournals.org/cancerdiscovery/article/10/4/536/2403/Monocytic-Subclones-Confer-Resistance-to8. VEN/DEC vs 7+3 https://ashpublications.org/blood/article/142/Supplement%201/970/503790/Comparing-the-Efficacy-and-Safety-of-Venetoclax9. FILO study: Outcomes of AML  https://onlinelibrary.wiley.com/doi/10.1002/ajh.2741710. Treatment-free remission after ceasing venetoclax-based therapy in patients with AML https://ashpublications-org.proxy.library.vanderbilt.edu/bloodadvances/article/6/13/3879/485175/Treatment-free-remission-after-ceasing-venetoclax11. Targeting molecular MRD and low-blast relapse in AML with Venetoclax and LDAC (VALDAC) https://ascopubs-org.proxy.library.vanderbilt.edu/doi/10.1200/JCO.23.01599?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed12. INTERCEPT trial: https://ashpublications.org/blood/article/140/Supplement%201/3341/492722/ALLG-AMLM26-Phase-1B-2-Study-Investigating-Novel

Get ready for a stomach-turning, heart-pounding, gravity-defying thrill ride as we plummet down, up, and all around the amazing world of roller coasters! We're joined by legendary podcaster, YouTuber, and roller coaster fanatic Tom Scott who wows us with his encyclopedic knowledge of these engineering marvels. So take a deep breath, strap in, and keep all your limbs inside the ride until the episode comes to a complete stop! Oh, and have fun!SciShow Tangents is on YouTube! Go to www.youtube.com/scishowtangents to check out this episode with the added bonus of seeing our faces! Head to www.patreon.com/SciShowTangents to find out how you can help support SciShow Tangents, and see all the cool perks you'll get in return, like bonus episodes and a monthly newsletter! A big thank you to Patreon subscriber Garth Riley for helping to make the show possible!And go to https://store.dftba.com/collections/scishow-tangents to buy some great Tangents merch!Follow us on Twitter @SciShowTangents, where we'll tweet out topics for upcoming episodes and you can ask the science couch questions! While you're at it, check out the Tangents crew on Twitter: Ceri: @ceriley Sam: @im_sam_schultz Hank: @hankgreen[This, That, or the Other: All Downhill from Here]https://www.goldreefcity.co.za/theme-park/rides-and-attractions/tower-of-terror/https://ntrs.nasa.gov/api/citations/20170005323/downloads/20170005323.pdfhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663089/https://www.ferrariworldabudhabi.com/en/rides/formula-rossa/worlds-fastest-rollercoasterhttps://www.youtube.com/watch?v=J8pJiV44hVMhttps://www.iaapa.org/news/funworld/tmnt-shellraiserhttps://pubmed.ncbi.nlm.nih.gov/3281645/https://www.powermotiontech.com/hydraulics/accumulators/article/21883506/want-thrills-go-with-hydraulics[Trivia Question]Annual deaths in roller coaster accidents in the United Stateshttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1730261https://www.weather.gov/safety/lightning-victimshttps://www.cpsc.gov/cgibin/NEISSQuery/Data/Info%20Docs/2023%20NEISS%20Coding%20Manual.pdf​​https://www.cpsc.gov/s3fs-public/2023-Fireworks-Annual-Report.pdf?VersionId=61twx_Y4c5dkn6MhfDIT7QhGg2T6Gf1qhttps://www.uspa.org/discover/faqs/safety[Fact Off]Riding roller coasters can help reduce perception of breathlessness/dyspneahttps://www.sciencedirect.com/science/article/abs/pii/S0005796706001653https://www.sciencedirect.com/science/article/pii/S0954611106003209https://journals.sagepub.com/doi/10.1191/1479972306cd110ra?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmedRiding in the back of Big Thunder Mountain Railroad can help dislodge kidney stones[Ask the Science Couch]Roller coaster stomach drop feeling and the enteric nervous systemhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7495222/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4367209/https://www.cbsnews.com/minnesota/news/good-question-why-does-your-stomach-drop-on-a-roller-coaster/https://www.visitkingsisland.com/blog/2020/may/roller-coaster-terminology-101Patreon bonus: Motion sickness and relation to agehttps://www.ncbi.nlm.nih.gov/books/NBK539706/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4906308/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11135238/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6241144/[Butt One More Thing]Dog-fart-themed steel roller coaster in Denmark's BonBon-Landhttps://www.mentalfloss.com/article/624229/take-virtual-ride-hundeprutterutchebane-denmarks-infamous-dog-fart-rollercoasterhttps://www.southzealand-mon.com/BonBon-Land

How will the medicine of the future look? Healthcare and medicine are on the verge of transformative change, driven by new technologies such as artificial intelligence, telemedicine, and wearable devices. Alongside the technologization and virtualization of medicine, there is a shift from reactive "fix the broken" approaches to preventative strategies and from one-size-fits-all treatments to personalized medicine. In this future, human healthcare professionals and machines will work hand-in-hand to deliver the best possible care, with empowered patients acting as equal decision-makers who understand and access their own healthcare data. However, a darker scenario could see medicine becoming fully industrialized and dehumanized. In episode 26 of We're Doomed, We're Saved, Andreas Horchler and Louise von Stechow outline the key trends shaping the future of medicine and discuss the opportunities and risks that accompany these developments. Content and Editing: Louise von Stechow and Andreas Horchler Disclaimer: Louise von Stechow & Andreas Horchler and their guests express their personal opinions, which are founded on research on the respective topics, but do not claim to give medical, investment or even life advice in the podcast. Learn more about the future of biotech in our podcasts and keynotes. Contact us here: scientific communication: https://science-tales.com/ Podcasts: https://www.podcon.de/ Keynotes: https://www.zukunftsinstitut.de/louise-von-stechow Image: alexander-sinn-KgLtFCgfC28-unsplash via Unsplash References: https://www.nature.com/articles/s41591-019-0693-y?fbclid=IwZXh0bgNhZW0CMTAAAR0RAb4UU5v5896AQfVNYfdCpLi80iN7JwoZux55ffxyI9W7TMsqVPakS3M_aem_49GYkWynL_l8fmMWXq_Xlg https://www.zukunftsinstitut.de/zukunftsthemen/megatrend-gesundheit https://www.nature.com/articles/s41591-024-03097-1#Sec9 https://www.nature.com/articles/s41591-023-02700-1 https://ai.nejm.org/doi/full/10.1056/AIcs2300145 https://www.nature.com/articles/s41599-022-01451-7 https://www.nejm.org/doi/10.1056/NEJMra2215899?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed https://www.imperial.ac.uk/news/167866/information-handling-some-health-apps-secure/ https://journals.sagepub.com/doi/full/10.1177/1357633X211022907 https://www.mckinsey.com/industries/life-sciences/our-insights/germanys-e-health-infrastructure-strengthens-but-digital-uptake-is-lagging https://www.mckinsey.com/industries/life-sciences/our-insights/german-e-health-offerings-expand-but-adoption-remains-uneven https://empeek.com/insights/everything-about-telemedicine-statistics-usage-trends/ https://blogs.deloitte.co.uk/health/2023/11/the-future-of-health-in-europe-digital-equitable-sustainable.html https://www2.deloitte.com/content/dam/Deloitte/uk/Documents/life-sciences-health-care/deloitte-uk-shaping-the-future-of-european-healthcare.pdf https://www.nature.com/articles/s41569-021-00522-7 https://web-assets.bcg.com/1e/74/5d14d48346bcb56a79c6e7e7ba0f/bcg-the-future-of-digital-health-2024-jan-2024-1.pdf

In this episode, we discuss updates on low-risk MDS with Dr. Maximilian Stahl with a focus on imetelstat and luspatercept. Here are the trials we discussed: 1. IWG 2019 response criteriahttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042664/ 2. MEDALIST trial: Luspatercepthttps://www.nejm.org/doi/10.1056/NEJMoa1908892?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed 3. COMMANDS trial : Luspatercept https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)00874-7/abstracthttps://www.thelancet.com/journals/lanhae/article/PIIS2352-3026(24)00203-5/abstract 4. IMerge trial: Imetelstat https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)01724-5/abstract  

In this episode, we discussed the diagnosis and management of polycythemia vera with Dr. Aaron T. Gerds. Here are the shownotes with the key studies discussed: 1.     MIPS PV scoring systemhttps://pubmed.ncbi.nlm.nih.gov/31945802/2.     REVEAL studyhttps://ashpublications.org/blood/article/143/16/1646/506717/Association-between-elevated-white-blood-cell3.     MAJIC PV studyhttps://ascopubs.org/doi/10.1200/JCO.22.01935?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed4.     Cyto-PV Studyhttps://www.nejm.org/doi/full/10.1056/NEJMoa12085005.     PROUD-PV and CONTINUATION-PV trialshttps://www.thelancet.com/journals/lanhae/article/PIIS2352-3026(19)30236-4/abstract6.     RESPONSE clinical trialhttps://www.nejm.org/doi/full/10.1056/NEJMoa14090027.     Rusferitide in PVhttps://www.nejm.org/doi/10.1056/NEJMoa2308809?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed

In a world fraught with injustice, perhaps the most pressing issue to address is… women breastfeeding their kids. According to transphobes, that is. You can WATCH the podcast over on our YouTube channel Help keep the show running by supporting us on Patreon! If you'd like to see more of us, follow our socials! sciguys.co.uk TikTok Twitter Instagram Facebook If you spot any points that need correcting, head to sciguys.co.uk/corrections Follow the Sci Guys @notcorry / @lukecutforth References & Further Reading Breastfeeding (and Chestfeeding) https://www.cdc.gov/breastfeeding/data/facts.html https://www.nhs.uk/medicines/hormone-replacement-therapy-hrt/oestrogen-tablets-patches-gel-and-spray/pregnancy-breastfeeding-and-fertility-while-taking-or-using-oestrogen-tablets-patches-gel-and-spray/ https://www.nhs.uk/pregnancy/having-a-baby-if-you-are-lgbt-plus/chestfeeding-if-youre-trans-or-non-binary/ Lactation https://www.ncbi.nlm.nih.gov/books/NBK499981/ https://www.babycenter.com/baby/breastfeeding/can-men-breastfeed_8824 https://my.clevelandclinic.org/health/body/22201-lactation Induced Lactation https://www.mayoclinic.org/healthy-lifestyle/infant-and-toddler-health/expert-answers/induced-lactation/faq-20058403 https://www.mayoclinic.org/healthy-lifestyle/infant-and-toddler-health/expert-answers/induced-lactation/faq-20058403 https://nestcollaborative.com/blog/four-things-to-know-about-induced-lactation/ Induced Lactation in Trans Women https://journals.sagepub.com/doi/10.1177/08903344231170559?url_ver=Z39.88-2003 https://ncbi.nlm.nih.gov/pmc/articles/PMC5779241/ https://pubmed.ncbi.nlm.nih.gov/38535753/ https://pubmed.ncbi.nlm.nih.gov/37138506/ https://internationalbreastfeedingjournal.biomedcentral.com/articles/10.1186/s13006-024-00624-1 https://www.economist.com/the-economist-explains/2024/02/23/can-transgender-women-breastfeed https://www.liebertpub.com/doi/10.1089/bfm.2024.0012 Trans Women Breastfeeding https://www.thepinknews.com/2024/05/28/trans-women-breastfeeding-explainer-research/ https://www.oprah.com/oprahshow/real-life-modern-family/all Milk Junkies Interviews http://www.milkjunkies.net/2017/05/jennas-breastfeeding-journey-trans.html http://www.milkjunkies.net/2013/05/trans-women-and-breastfeeding-personal.html http://www.milkjunkies.net/2013/07/trans-women-and-breastfeeding-health.html HRT & Breastfeeding  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370611/ https://cks.nice.org.uk/topics/menopause/prescribing-information/hormone-replacement-therapy-hrt/ https://www.balance-menopause.com/menopause-library/breastfeeding-hrt/ https://breastfeeding-and-medication.co.uk/fact-sheet/the-menopause-and-breastfeeding https://www.womens-health-concern.org/wp-content/uploads/2022/11/27-WHC-FACTSHEET-HRT-Doses-NOV2022-A.pdf

In this episode, Dr. Ally Baheti interviews interventional radiologist Dr. Lorenzo Patrone about his recent multidisciplinary editorial entitled "The 'Woundosome' Concept and Its Impact on Procedural Outcomes in Patients With Chronic Limb-Threatening Ischemia.” --- CHECK OUT OUR SPONSOR Reflow Medical https://www.reflowmedical.com/ --- SYNPOSIS Dr. Patrone explains his interest in critical limb ischemia (CLI) and describes how he reached out to colleagues around the world with the intention of drafting a paper that summarizes research in below-the-ankle interventions and increases awareness of the woundosome concept. He explains the woundosome concept, which aims to understand how each patient's foot vasculature influences the effectiveness of below-the-ankle interventions and tissue healing. Understanding each patient's anatomy, having adequate imaging of the foot, obtaining pedal acceleration times, and using micro-oxygen sensors are strategies to assess wound perfusion, which is integral for treatment planning and prognosis. He illustrates these techniques in a case study of a non-healing wound. Finally, Dr. Patrone shares some technical tips for below-the-ankle interventions, including the benefits of ipsilateral antegrade access, sheath selection, and strategic contrast administration. --- TIMESTAMPS 00:00 - Introduction 02:25 - Multidisciplinary and Global Collaboration 05:59 - Explaining the Woundosome Concept 07:51 - Understanding Wound Perfusion 10:20 - Assessing the Effectiveness of Revascularization 20:09 - Case Example with Pictures 28:07 - Technical Tips for CLI Interventions --- RESOURCES Find Your Algorithm (FYA): https://fya-congress.com/ The "Woundosome" Concept and Its Impact on Procedural Outcomes in Patients With Chronic Limb-Threatening Ischemia: https://journals.sagepub.com/doi/10.1177/15266028241231745?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed Vascular imaging of the foot: the first step toward endovascular recanalization (Manzi): https://pubmed.ncbi.nlm.nih.gov/21997985/ BASIL-2 Trial: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)00462-2/fulltext BackTable VI Ep. 90- Pedal Acceleration Time for Limb Salvage with Jill Sommerset and Dr. Mary Constantino: https://www.backtable.com/shows/vi/podcasts/90/pedal-acceleration-time-for-limb-salvage The First-in-Man "Si Se Puede" Study for the use of micro-oxygen sensors (Montero-Baker): https://pubmed.ncbi.nlm.nih.gov/26004327/ PEDRA Perfusion Monitoring: https://www.pedratech.com/ Armada XT Balloon: https://www.cardiovascular.abbott/us/en/hcp/products/peripheral-intervention/peripheral-dilatation-catheters/armada-14.html

In this episode, we discuss updates in primary myelofibrosis with Dr. Ayalew Tefferi from the Mayo Clinic. The key studies and trials discussed are as follows: ·       GIPSS: Genetically inspired prognostic scoring system that is exclusively based on genetic markers. §  https://www.nature.com/articles/s41375-018-0107-z ·       MIPSS70+ Version 2.0: Mutation and Karyotype-Enhanced International Prognostic Scoring System for Primary Myelofibrosis §  https://ascopubs.org/doi/10.1200/JCO.2018.78.9867?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed ·       TRANSFORM-1: A Randomized, Double-Blind, Placebo-Controlled, Multicenter, International Phase 3 Study of Navitoclax in Combination with Ruxolitinib Versus Ruxolitinib Plus Placebo in Patients with Untreated Myelofibrosis §  https://ashpublications.org/blood/article/142/Supplement%201/620/502738/Transform-1-A-Randomized-Double-Blind-Placebo ·       MANIFEST-2: Pelabresib in Combination with Ruxolitinib for Janus Kinase Inhibitor Treatment-Naïve Patients with Myelofibrosis: Results of the MANIFEST-2 Randomized, Double-Blind, Phase 3 Study §  https://ashpublications.org/blood/article/142/Supplement%201/628/502728/Pelabresib-in-Combination-with-Ruxolitinib-for ·       XPORT-MF-034: Selinexor Plus Ruxolitinib in JAK Inhibitor (JAKi)-Naïve Patients with Myelofibrosis: Long Term Follow up from XPORT-MF-034 Suggestive of Disease Modification 

In many parts of the world, Bevacizumab is an important component of the treatment of glioblastoma, colorectal, hepatocellular and ovarian cancers. However, with such widespread use inevitably comes toxicity. Side effects related to bevacizumab are not your garden-variety chemotherapy side effects, nor are they similar to toxicity from immunotherapy. Rather, they stand apart, unique amongst our systemic therapies.In their latest Onconack, Josh and Michael take a look at two of the most commonly described toxicities related to bevacizumab: hypertension and proteinuria. This is sure to be a valuable resource to any oncology trainee blessed (or cursed) with the unit pager!Links to useful sources for further reading (subscription may be required):Chemotherapy plus bevacizumab as an optimal first-line therapeutic treatment for patients with right-sided metastatic colon cancer: a meta-analysis of first-line clinical trials. https://doi.org/10.1136/esmoopen-2019-000605Practical Management of Bevacizumab-Related Toxicities in Glioblastoma. https://pubmed.ncbi.nlm.nih.gov/25568148/Incorporation of Bevacizumab in the Primary Treatment of Ovarian Cancer. https://www.nejm.org/doi/10.1056/NEJMoa1104390?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200www.ncbi.nlm.nih.govBevacizumab Increases Risk for Severe Proteinuria in Cancer Patients. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2938590/For more episodes, resources and blog posts, visit www.inquisitiveonc.comFind us on Twitter @InquisitiveOnc!If you want us to look at a specific trial or subject, email us at inquisitiveonc@gmail.comArt courtesy of Taryn SilverMusic courtesy of Music Unlimited: https://pixabay.com/users/music_unlimited-27600023/Disclaimer: This podcast is for educational purposes only. If you are unwell, seek medical advice. Hosted on Acast. See acast.com/privacy for more information.

View Part 1 here: https://youtube.com/live/VCJdne9xgqgDr. Sabine Hazan returns to the Zone to discuss various aspects of the microbiome and its impact on health. During her conversation with Dr. Osborne, they explore topics such as fecal transplants, inflammatory bowel disease, and the differences in microbiomes between individuals.They also discuss the effects of cesarean section versus vaginal birth on the newborn's microbiome and the potential implications of imbalances in the overall microbiome of the planet. The conversation highlights the need for more research and funding in the field of microbiome studies. They discuss the potential benefits of fecal transplants for various conditions, including inflammatory bowel disease and autism.Some of Dr. Hazan's work discussed in this interview is posted below:Vitamin C improves gut Bifidobacteria in humans https://www.futuremedicine.com/doi/full/10.2217/fmb-2022-0209?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.orgDetection of SARS-CoV-2 from patient fecal samples by whole genome sequencing https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7846909/Microbiome-Based Hypothesis on Ivermectin's Mechanism in COVID-19: Ivermectin Feeds Bifidobacteria to Boost Immunity. https://pesquisa.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/resource/en/covidwho-1963494Lost microbes of COVID-19: Bifidobacterium, Faecalibacterium depletion and decreased microbiome diversity associated with SARS-CoV-2 infection severity. https://pesquisa.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/resource/en/covidwho-1816751Effectiveness of ivermectin-based multidrug therapy in severely hypoxic, ambulatory COVID-19 patients https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8826831/To connect with Dr. Osborne visit:On the web: https://drpeterosborne.com/ Facebook: https://www.facebook.com/DoctorPeterOsborne/Pinterest: https://www.pinterest.com/docosborne/Instagram: https://www.instagram.com/drosborneTwitter: https://twitter.com/glutenology*These statements have not been evaluated by the Food and Drug Administration. This video is not intended to diagnose, treat, cure or prevent any disease. It is strictly intended for educational purposes only. Additionally, this information is not intended to replace the advice of your physician. Dr. Peter Osborne is one of the most sought after alternative and nutritional experts in the world. A Diplomate with the American Clinical Board of Nutrition, a graduate of Texas Chiropractic College, and a doctor of pastoral science, Dr. Osborne is one of the world's leading authorities on gluten, nutrition, and natural health. He is the founder GlutenFreeSociety.org, one of the world's largest informational sites on gluten sensitivity. In addition, he is the author of the best selling book, No Grain No Pain, published by Touchstone (Simon & Schuster). His work has been featured by PBS, Netflix, Amazon, Fox, and many other nationally recognized outlets. For more information, visit us at https://www.glutenfreesociety.org/ or call 281-903-7527

Episode Notes The Society of Infectious Diseases Pharmacists is excited to invite you to the first ever meeting (via Breakpoints) of The Tortured Stewards & Surgeons Department. Today's agenda items: optimal management of perioperative antibiotics and prevention of surgical site infections. Drs. Trisha Peel (@DrTrishaPeel), Michael Calderwood (@CalderwoodMD) and Patch Dellinger join Dr. Jillian Hayes (@thejillianhayes) to discuss some of the controversies we encounter while managing antibiotics in the perioperative space. Does anyone really need post-op antimicrobial prophylaxis longer than 24 hours? Where should vancomycin be fitting into surgical prophylaxis regimens? Can we truly give pre-operative cefazolin to patients with a penicillin allergy? Tune in for the answers to these questions and more! Learn more about the Society of Infectious Diseases Pharmacists: https://sidp.org/About X: @SIDPharm (https://twitter.com/SIDPharm) Instagram: @SIDPharm (https://www.instagram.com/sidpharm/) Facebook: https://www.facebook.com/sidprx LinkedIn: https://www.linkedin.com/company/sidp If you'd like more information about the CALIPSO trial, please visit this link: https://www.anzca.edu.au/profiles/ctn-trials/underway/calipso Bibliography SSI Infection Prevention Review: https://jamanetwork.com/journals/jama/article-abstract/2800424#:~:text=Six%20are%20supported%20by%20randomized,use%20a%20chlorhexidine%20gluconate%2Dalcoho Strategies to prevent surgical site infections in acute-care hospitals: 2022 Update: https://www.cambridge.org/core/journals/infection-control-and-hospital-epidemiology/article/strategies-to-prevent-surgical-site-infections-in-acutecare-hospitals-2022-update/2F824B9ADD6066B29F89C8A2A127A9D American College of Surgeons and Surgical Infection Society: Surgical Site Infection Guidelines, 2016 Update: https://journals.lww.com/journalacs/citation/2017/01000/american_college_of_surgeons_and_surgical.8.aspx  2017 CDC Guidelines: https://jamanetwork.com/journals/jamasurgery/fullarticle/2623725  2018 WHO Guidelines: https://arthroplasty.biomedcentral.com/articles/10.1186/s42836-022-00113-y  ASHP Clinical Practice Guidelines for Antimicrobial Prophylaxis in Surgery: https://www.ashp.org/surgical-guidelines  Surgeons as Stewards: https://journals.lww.com/journalacs/citation/2020/12000/perioperative_antibiotic_prophylaxis__surgeons_as.23.aspx  Li et al, Arthroplasty 2022: https://arthroplasty.biomedcentral.com/articles/10.1186/s42836-022-00113-y  Dutch Arthroplasty Register Study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8023957/  de Jonge Meta-Analysis on duration and incidence of SSI: https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(20)30084-0/abstract  Prolonged Antibiotic Prophylaxis After Cardiovascular Surgery and Its Effect on Surgical Site Infections and Antimicrobial Resistance: https://www.ahajournals.org/doi/10.1161/01.cir.101.25.2916?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed RCT - Nasal Iodophor Antiseptic vs Nasal Mupirocin Antibiotic in the Setting of Chlorhexidine Bathing to Prevent Infections in Adult ICUs: https://jamanetwork.com/journals/jama/article-abstract/2810510  NYU Langone Study - Preventing Surgical Site Infections: A Randomized, Open-Label Trial of Nasal Mupirocin Ointment and Nasal Povidone-Iodine Solution: https://citeseerx.ist.psu.edu/document?repid=rep1&type=pdf&doi=91dee3e1445adb80d533f2c210816a3285254e3a  Trial of Vancomycin and Cefazolin as Surgical Prophylaxis in Arthroplasty: https://www.nejm.org/doi/full/10.1056/NEJMoa2301401 What Is the Primary Driver of Preoperative Vancomycin Use? It's Not Methicillin-resistant Staphylococcus aureus—or Allergy: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7744972/  Drug allergy: a 2022 practice parameter update: https://www.jacionline.org/article/S0091-6749(22)01186-1/fulltext  Perioperative use of cefazolin without preliminary skin testing in patients with reported penicillin allergy: https://www.surgjournal.com/article/S0039-6060(18)30307-6/abstract#%20  Timing of Surgical Prophylaxis RCT: https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(17)30176-7/abstract  Propensity Score-Weighted Analysis of Postoperative Infection in Patients With and Without Preoperative Urine Culture: https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2815528

Welcome back to Working Weights LLC, where we delve deep into the science and practicality of fitness and wellness. In this episode, Coach Lamby and co-host Dwayne tackle a fascinating topic: the disparity between brown fat and white fat, and how understanding this difference can impact your fitness journey.Brown fat, often dubbed as the "good fat," and white fat, its counterpart, have garnered attention for their distinct roles in metabolism and thermogenesis. But what exactly sets them apart? Coach Lamby and Dwayne break down the physiological differences between these two types of adipose tissue and their implications for weight management.Furthermore, they explore the evidence surrounding methods to activate brown fat, particularly the debate over the effectiveness of cold plunges. Does subjecting yourself to icy temperatures truly stimulate brown fat activation? And if so, how significant are the potential benefits for fat loss and achieving that coveted shredded physique?Drawing upon scientific research and practical experience, Coach Lamby and Dwayne delve into the nuances of brown fat activation strategies, weighing the pros and cons of cold exposure techniques. They offer insights into integrating these methods into your fitness routine and discuss their potential synergies with other weight loss approaches.So, if you're curious about the science behind fat metabolism, the efficacy of cold plunges, and how understanding brown fat could revolutionize your fitness journey, tune in to this episode of Working Weights LLC. Get ready to elevate your knowledge and optimize your path to achieving your fitness goals!https://youtu.be/7UonfOoIl18https://journals.physiology.org/doi/full/10.1152/physrev.00015.2003?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.orghttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7988785/https://pubmed.ncbi.nlm.nih.gov/28099124/https://www.nejm.org/doi/10.1056/NEJMoa0808718?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200www.ncbi.nlm.nih.govhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627770/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536824/https://sportrxiv.org/index.php/server/preprint/view/301/603

With record-cold temperatures in much of the United States this winter, a high number of cold injuries have been reported. This podcast discusses prevention and treatment for hypothermia and frostbite. Brrrrr! The GameChangers: Frostbite prevention using layers and heating measuresHypothermia treatment using external and internal heating Frostbite treatment with anticoagulants HostGeoff Wall, PharmD, BCPS, FCCP, BCGPProfessor of Pharmacy Practice, Drake UniversityInternal Medicine/Critical Care, UnityPoint Health Referencehttps://www-nejm-org./doi/10.1056/NEJMra1800868?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed Pharmacist Members, REDEEM YOUR CPE HERE! Not a member? Get a Pharmacist Membership & earn CE for GameChangers Podcast episodes! (30 mins/episode)CPE Information Learning ObjectivesUpon successful completion of this knowledge-based activity, participants should be able to:1. Differentiate between types of hypothermia2. Discuss treatments for frostbite0.05 CEU/0.5 HrUAN: 0107-0000-24-051-H01-P Initial release date: 2/12/2024Expiration date: 2/12/2025Additional CPE details can be found here.Follow CEimpact on Social Media:LinkedInInstagram

Estudios: - Aumento de Testosterona en Hombres al beber poco alcohol https://pubmed.ncbi.nlm.nih.gov/12711931/ - [Associations between alcohol consumption and gray and white matter volumes in the UK Biobank](https://www.nature.com/articles/s41467-022-28735-5) (*Nature Communications*) - [Gut Microbiota at the Intersection of Alcohol, Brain, and the Liver](https://www.mdpi.com/2077-0383/10/3/541) (*Journal of Clinical Medicine*) - [Tolerance to alcohol: A critical yet understudied factor in alcohol addiction](https://www.sciencedirect.com/science/article/abs/pii/S009130572100054X?via%3Dihub) (*Pharmacology Biochemistry and Behavior*) - [Associations Between Drinking and Cortical Thickness in Younger Adult Drinkers: Findings From the Human Connectome Project](https://onlinelibrary.wiley.com/doi/10.1111/acer.14147) (*Alcoholism: Clinical and Experimental Research*) - [Moderate Alcohol Consumption and the Risk of Breast Cancer](https://www.nejm.org/doi/10.1056/NEJM198705073161902?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed) (*The New England Journal of Medicine*) - [Can alcohol promote aromatization of androgens to estrogens? A review](https://www.sciencedirect.com/science/article/abs/pii/S0741832900001245?via%3Dihub) (*Alcohol*) Sé parte de nuestra comunidad de Creadores y obtén recursos, herramientas y estrategias gratuitas para mejorar tu vida y alcanzar tu máximo potencial. Encuéntranos en: - Este Canal: https://bit.ly/3et1LTB - Spotify: https://spoti.fi/2XN3zSe - iTunes: https://apple.co/2ZlON5O 2. CONECTEMOS EN… - Facebook: https://www.facebook.com/MarceloZegar... - Instagram: https://www.instagram.com/creadorespodcast/ - TikTok: https://www.tiktok.com/@chelozegarra 3. ÚNETE A NUESTRO EXCLUSIVO GRUPO KIERO EMPRENDER EN FACEBOOK: - https://bit.ly/32RfDEl --- Send in a voice message: https://podcasters.spotify.com/pod/show/creadorespodcast/message

OutlineChapter 14- Hypovolemic States- Etiology - True volume depletion occurs when fluid is lost from from the extracellular fluid at a rate exceeding intake - Can come the GI tract - Lungs - Urine - Sequestration in the body in a “third space” that is not in equilibrium with the extracellular fluid. - When losses occur two responses ameliorate them - Our intake of Na and fluid is way above basal needs - This is not the case with anorexia or vomiting - The kidney responds by minimizing further urinary losses - This adaptive response is why diuretics do not cause progressive volume depletion - Initial volume loss stimulates RAAS, and possibly other compensatory mechanisms, resulting increased proximal and collecting tubule Na reabsorption. - This balances the diuretic effect resulting in a new steady state in 1-2weeks - New steady state means Na in = Na out - GI Losses - Stomach, pancreas, GB, and intestines secretes 3-6 liters a day. - Almost all is reabsorbed with only loss of 100-200 ml in stool a day - Volume depletion can result from surgical drainage or failure of reabsorption - Acid base disturbances with GI losses - Stomach losses cause metabolic alkalosis - Intestinal, pancreatic and biliary secretions are alkalotic so losing them causes metabolic acidosis - Fistulas, laxative abuse, diarrhea, ostomies, tube drainage - High content of potassium so associated with hypokalemia - [This is a mistake for stomach losses] - Bleeding from the GI tract can also cause volume depletion - No electrolyte disorders from this unless lactic acidosis - Renal losses - 130-180 liters filtered every day - 98-99% reabsorbed - Urine output of 1-2 liters - A small 1-2% decrease in reabsorption can lead to 2-4 liter increase in Na and Water excretion - 4 liters of urine output is the goal of therapeutic diuresis which means a reduction of fluid reabsorption of only 2% - Diuretics - Osmotic diuretics - Severe hyperglycemia can contribute to a fluid deficit of 8-10 Iiters - CKD with GFR < 25 are poor Na conservers - Obligate sodium losses of 10 to 40 mEq/day - Normal people can reduce obligate Na losses down to 5 mEq/day - Usually not a problem because most people eat way more than 10-40 mEq of Na a day. - Salt wasting nephropathies - Water losses of 2 liters a day - 100 mEq of Na a day - Tubular and interstitial diseases - Medullary cystic kidney - Mechanism - Increased urea can be an osmotic diuretic - Damage to tubular epithelium can make it aldo resistant - Inability to shut off natriuretic hormone (ANP?) - The decreased nephro number means they need to be able to decrease sodium reabsorption per nephron. This may not be able to be shut down acutely. - Experiment, salt wasters can stay in balance if sodium intake is slowly decreased. (Think weeks) - Talks about post obstruction diuresis - Says it is usually appropriate rather than inappropriate physiology. - Usually catch up solute and water clearance after releasing obstruction - Recommends 50-75/hr of half normal saline - Talks briefly about DI - Skin and respiratory losses - 700-1000 ml of water lost daily by evaporation, insensible losses (not sweat) - Can rise to 1-2 liters per hour in dry hot climate - 30-50 mEq/L Na - Thirst is primary compensation for this - Sweat sodium losses can result in hypovolemia - Burns and exudative skin losses changes the nature of fluid losses resulting in fluid losses more similar to plasma with a variable amount of protein - Bronchorrhea - Sequestration into a third space - Volume Deficiency produced by the loss of interstitial and intravascular fluid into a third space that is not in equilibrium with the extracellular fluid. - Hip fracture 1500-2000 into tissues adjacent to fxr - Intestinal obstruction, severe pancreatitis, crush injury, bleeding, peritonitis, obstruction of a major venous system - Difference between 3rd space and cirrhosis ascities - Rate of accumulation, if the rate is slow enough there is time for renal sodium and water compensation to maintain balance. - So cirrhotics get edema from salt retension and do not act as hypovolemia - Hemodynamic response to volume depletion - Initial volume deficit reduced venous return to heart - Detected by cardiopulmonary receptors in atria and pulmonary veins leading to sympathetic vasoconstriction in skin and skeletal muscle. - More marked depletion will result in decreased cardiac output and decrease in BP - This drop in BP is now detected by carotid and aortic arch baroreceptors resulting in splanchnic and renal circulation vasoconstriction - This maintains cardiac and cerebral circulation - Returns BP toward normal - Increase in BP due to increased venous return - Increased cardiac contractility and heart rate - Increased vascular resistance - Sympathetic tone - Renin leading to Ang2 - These can compensate for 500 ml of blood loss (10%) - Unless there is autonomic dysfunction - With 16-25% loss this will not compensate for BP when patient upright - Postural dizziness - Symptoms - Three sets of symptoms can occur in hypovolemic patients - Those related to the manner in which the fluid loss occurs - Vomiting - Diarrhea - Polyuria - Those due to volume depletion - Those due to the electrode and acid base disorders that can accompany volume depletion - The symptoms of volume depletion are primarily related to the decrease in tissue perfusion - Early symptoms - Lassitude - Fatiguability - Thirst - Muscle cramps - Postural dizziness - As it gets more severe - Abdominal pain - Chest pain - Lethargy - Confusion - Symptomatic hypovolemia is most common with isosmotic Na and water depletion - In contrast pure water loss, causes hypernatremia, which results in movement of water from the intracellular compartment to the extracellular compartment, so that 2/3s of volume loss comes from the intracellular compartment, which minimizes the decrease in perfusion - Electrolyte disorders and symptoms - Muscle weakness from hypokalemia - Polyuria/poly dips is from hyperglycemia and hypokalemia - Lethargy, confusion, Seizures, coma from hyponatremia, hypernatremia, hyperglycemia - Extreme salt craving is unique to adrenal insufficiency - Eating salt off hands ref 18 - Evaluation of the hypovolemic patient - Know that if the losses are insensible then the sodium should rise - Volume depletion refers to extracellular volume depletion of any cause, while dehydration refers to the presence of hypernatremia due to pure water loss. Such patients are also hypovolemic. - Physical exam is insensitive and nonspecific - Finding most sensitive and specific finding for bleeding is postural changes in blood pressure - I don't find this very specific at all! - Recommends laboratory confirmation regardless of physical exam - Skin and mucous membranes - Should return too shape quickly - Elastic property is called Turgur - Not reliable is patients older than 55 to 60 - Dry axilla - Dry mucus membranes - Dark skin in Addison's disease Frim increased ACTH - Arterial BP - As volume goes down so does arterial BP - Marked fluid loss leads to quiet korotkoff signs - Interpret BP in terms of the patients “normal BP” - Venous pressure - Best done by looking at the JVP - Right atrial and left atrial pressure - LV EDP is RAP + 5 mmHg - Be careful if valvular disease, right heart failure, cor pulmonare, - Figure 14-2 - Shock - 30% blood loss - Lab Data - Urine Na concentration - Should be less than 25 mmol/L, can go as low as 1 mmol/L - Metabolic alkalosis can throw this off - Look to the urine chloride - Figure 14-3 - Renal artery stenosis can throw this off - FENa - Mentions that it doesn't work so well at high GFR - Urine osmolality - Indicates ADH - Volume depletion often associated with urine osm > 450 - Impaired by - Renal disease - Osmotic diuretic - Diuretics - DI - Mentions that severe volume depletion and hypokalemia impairs urea retension in renal medulla - Points out that isotonic urine does not rule out hypovolemia - Mentions specific gravity - BUN and Cr concentration - Normal ratio is 10:1 - Volume depletion this goes to 20:1 - Serum Na - Talks about diarrhea - Difference between secretory diarrhea which is isotonic and just causes hypovolemia - And osmotic which results in a lower electrolyte content and development of hypernatremia - Talks about hyperglycemia - Also can cause the sodium to rise from the low electrolyte content of the urine - But the pseudohyponatraemia can protect against this - Plasma potassium - Treatment - Both oral and IV treatment can be used for volume replacement - The goal of therapy are to restore normovolemia - And to correct associated acid-base and electrolyte disorders - Oral Therapy - Usually can be accomplished with increased water and dietary sodium - May use salt tablets - Glucose often added to resuscitation fluids - Provides calories - Promotes intestinal Na reabsorption since there is coupled Na and Glucose similar to that seen in the proximal tubule - Rice based solutions provide more calories and amino acids which also promote sodium reabsorption - 80g/L of glucose with rice vs 20 g/L with glucose alone - IV therapy - Dextrose solutions - Physiologically equivalent to water - For correcting hypernatremia - For covering insensible losses - Watch for hyperglycemia - Footnote warns against giving sterile water - Saline solutions - Most hypovolemic patients have a water and a sodium deficit - Isotonic saline has a Na concentration of 154, similar to that of plasma see page 000 - Half-isotonic saline is equivalent to 550 ml of isotonic saline and 500 of free water. Is that a typo? - 3% is a liter of hypertonic saline and 359 extra mEq of Na - Dextrose in saline solutions - Give a small amount of calories, otherwise useless - Alkalinizing solutions - 7.5% NaHCO3 in 50 ml ampules 44 mEq of Na and 44 mEq of HCO3 - Treat metabolic acidosis or hyperkalemia - Why 44 mEq and not 50? - Do not give with calcium will form insoluble CaCO3 - Polyionic solutions - Ringers contains physiologic K and Ca - Lactated Ringers adds 28 mEq of lactate - Spreads myth of LR in lactic acidosis - Potassium chloride - Available as 2 mEq/mL - Do not give as a bolus as it can cause fatal hyperkalemia - Plasma volume expanders - Albumin, polygelastins, hetastarch are restricted to vascular space - 25% albumin can pull fluid into the vascular space - 25% albumin is an albumin concentration of 25 g/dL compare to physiologic 4 g/dL - Says it pulls in several times its own volume - 5% albumin is like giving plasma - Blood - Which fluid? - Look at osmolality, give hypotonic fluids to people with high osmolality - Must include all electrolytes - Example of adding 77 mEw of K to 0.45 NS and making it isotonic - DI can be replaced with dextrose solutions, pure water deficit - Case 14-3 - Diarrhea with metabolic acidosis - He chooses 0.25 NS with 44 mEq of NaCl and 44 NaHCO3 - Talks about blood and trauma - Some studies advocate delaying saline until penetrating trauma is corrected APR about to. Keep BP low to prevent bleeding. Worry about diluting coagulation factors - Only do this if the OR is quickly available - Volume deficit - Provides formula for water deficit and sodium deficit - Do not work for isotonic losses - Provides a table to adjust fluid loss based on changes in Hgb or HCTZ - Says difficult to estimate it from lab findings and calculations - Follow serial exams - Serial urine Na - Rate of replacement - Goal is not to give fluid but to induce a positive balance - Suggests 50-100 ml/hr over what is coming out of the body - Urine - Insensibles 30-50 - Diarrhea - Tubes - Hypovolemic shock - Due to bleeding - Sequesting in third space - Why shock? - Progressive volume depletion leads to - Increased sympathetic NS - Increased Ang 2 - Initially this maintains BP, cerebral and coronary circulation - But this can decrease splanchnic, renal and mucocutaneous perfusion - This leads to lactic acicosis - This can result in intracellular contents moving into circulation or translocation of gut bacteria - Early therapy to prevent irreversible shock - In dogs need to treat with in 2 hours - In humans may need more than 4 hours - Irreversible shock associated with pooling of blood in capillaries - Vasomotor paralysis - Hyperpolarization of vascular smooth muscle as depletion of ATP allows K to flowing out from K channels opening. Ca flows out too leading to vasodilation - Glyburide is an K-ATP channel inhibitor (?) caused increased vasoconstriction and BP - Pluggin of capillaries by neutrophils - Cerebral ischemia - Increased NO generation - Which Fluids? - Think of what is lost and replace that. - Bleeding think blood - Raise the hct but not above 35 - Acellular blood substitutes, looked bad at the time of this writing - Di aspirin cross linked hemoglobin had increased 2 and 28 day mortality vs saline - Colloids sound great but they fail in RCTs - SAFE - FEAST - Points out that saline replaces the interstitial losses why do we think those losses are unimportant - Pulmonary circulation issue - Pulmonary circulation is more leaky so oncotic pressure less effective there - Talks about the lungs be naturally protected from pulmonary edema - Rate of fluid - 1-2 liters in first hour - Suggests CVP or capillary wedge pressure during resuscitation - No refs in the rate of fluid administration section - Lactic acidosis - Points out that HCO can impair lactate utilization - Also states that arterial pH does not point out what is happening at the tissue level. Suggests mixed-venous sample.ReferencesJCI - Phenotypic and pharmacogenetic evaluation of patients with thiazide-induced hyponatremia and a nice review of this topic: Altered Prostaglandin Signaling as a Cause of Thiazide-Induced HyponatremiaThe electrolyte concentration of human gastric secretion. https://physoc.onlinelibrary.wiley.com/doi/10.1113/expphysiol.1960.sp001428A classic by Danovitch and Bricker: Reversibility of the “Salt-Losing” Tendency of Chronic Renal Failure | NEJMOsmotic Diuresis Due to Retained Urea after Release of Obstructive Uropathy | NEJMIs This Patient Hypovolemic? | Cardiology | JAMAAnd by the same author, a textbook: Steven McGee. 5th edition. Evidence-Based Physical Diagnosis Elsevier Philadelphia 2022. ISBN-13: 978-0323754835The clinical course and pathophysiological investigation of adolescent gestational diabetes insipidus: a case report | BMC Endocrine DisordersSensitivity and specificity of clinical signs for assessment of dehydration in endurance athletes | British Journal of Sports MedicineDiagnostic performance of serum blood urea nitrogen to creatinine ratio for distinguishing prerenal from intrinsic acute kidney injury in the emergency department | BMC NephrologyThe meaning of the blood urea nitrogen/creatinine ratio in acute kidney injury - PMCLanguage guiding therapy: the case for dehydration vs volume depletion https://www.acpjournals.org/doi/10.7326/0003-4819-127-9-199711010-00020?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmedValidation of a noninvasive monitor to continuously trend individual responses to hypovolemiaReferences for Anna's voice of God on Third Spacing : Shires Paper from 1964 (The ‘third space' – fact or fiction? )References for melanie's VOG:1. Appraising the Preclinical Evidence of the Role of the Renin-Angiotensin-Aldosterone System in Antenatal Programming of Maternal and Offspring Cardiovascular Health Across the Life Course: Moving the Field Forward: A Scientific Statement From the American Heart Association2. excellent review of RAAS in pregnancy: The enigma of continual plasma volume expansion in pregnancy: critical role of the renin-angiotensin-aldosterone systemhttps://journals-physiology-org.ezp-prod1.hul.harvard.edu/doi/full/10.1152/ajprenal.00129.20163. 10.1172/JCI107462- classic study in JCI of AngII responsiveness during pregnancy4. William's Obstetrics 26th edition!5. Feto-maternal osmotic balance at term. A prospective observational study

This week, Paul talks to Mike Fave, critical care RN, about all things sugar & fructose. They share their thoughts on a recent podcast with Andrew Huberman and Alex Lustig, and why they disagree with certain points made about insulin, fruit juice, and fructose. 00:00:00 Podcast begins 00:04:00 Mike's background 00:05:15 Diving into fructose 00:13:00 Thoughts on honey and other carb sources 00:27:30 Robert Lustig rebuttal: is fructose addictive? 00:37:40 Fructose & fiber 00:47:00 How fructose affects the mitochondria 00:51:00 Clarifying hyperglycemia vs. a postprandial hyperglycemia 00:56:17 Is insulin the bad guy? 01:12:20 How insulin relates to diabetes, obesity, and insulin resistance 01:23:30 Balancing protein, fat and carbohydrates 01:30:00 Is fructose making us fat? 01:46:00 Final thoughts Connect with Mike: Mikefave.com https://m.youtube.com/@MikeFaveSimplified References: Review article: fructose malabsorption and the bigger picture: https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2036.2006.03186.x A Relationship between Reduced Nucleus Accumbens Shell and Enhanced Lateral Hypothalamic Orexin Neuronal Activation in Long-Term Fructose Bingeing Behavior: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988143/ A High-Fat Meal, or Intraperitoneal Administration of a Fat Emulsion, Increases Extracellular Dopamine in the Nucleus Accumbens: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4061790/ A Relationship between Reduced Nucleus Accumbens Shell and Enhanced Lateral Hypothalamic Orexin Neuronal Activation in Long-Term Fructose Bingeing Behavior: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988143/ The regulation of glucose metabolism: implications and considerations for the assessment of glucose homeostasis in rodents: https://journals.physiology.org/doi/full/10.1152/ajpendo.00165.2014?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org Consumption of Raw Orange, 100% Fresh Orange Juice, and Nectar- Sweetened Orange Juice—Effects on Blood Glucose and Insulin Levels on Healthy Subjects: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770506/ The Effects of Soluble Dietary Fibers on Glycemic Response: An Overview and Futures Perspectives: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9736284/#B37-foods-11-03934 The Effects of Soluble Dietary Fibers on Glycemic Response: An Overview and Futures Perspectives: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9736284/#B37-foods-11-03934 Formation of Fructose-Mediated Advanced Glycation End Products and Their Roles in Metabolic and Inflammatory Diseases: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5227984/ Altered glycolytic and oxidative capacities of skeletal muscle contribute to insulin resistance in NIDDM: https://pubmed.ncbi.nlm.nih.gov/9216960/ Glucagon and type 2 diabetes: the return of the alpha cell: https://pubmed.ncbi.nlm.nih.gov/25344790/ Insulin, growth hormone and sport: https://pubmed.ncbi.nlm.nih.gov/11431133/ Effect of Mild Physiologic Hyperglycemia on Insulin Secretion, Insulin Clearance, and Insulin Sensitivity in Healthy Glucose-Tolerant Subjects: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881846/ Fructose metabolism in humans – what isotopic tracer studies tell us: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533803/ Absorption capacity of fructose in healthy adults. Comparison with sucrose and its constituent monosaccharides: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1433856/ Review article: fructose malabsorption and the bigger picture: https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2036.2006.03186.x Toll-like receptor 4 is involved in the development of fructose-induced hepatic steatosis in mice: https://pubmed.ncbi.nlm.nih.gov/19637282/ Fructose Promotes Leaky Gut, Endotoxemia and Liver Fibrosis through CYP2E1-Mediated Oxidative and Nitrative Stress: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783321/

Nothing discussed in this podcast is EVER medical advice, consult your physician for medical needs. Recent article summarizing Dr. Bryan's reserach: https://www.colorado.edu/today/2024/01/03/study-cannabis-can-make-workouts-more-fun-its-no-performance-enhancer Dr. Bryans research papers: https://www.liebertpub.com/doi/10.1089/can.2022.0338?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed   Please note... additional research is available behind paywalls but can be found and downloaded on the Bioactive Patreon page   Patreon www.patreon.com/cannabichem MAD LOVE MY FRIENDS

What is VO2max? Is Garmin VO2Max accurate? How much is genetic vs trainable? What contributes to running performance? Dave and Matt discuss vo2 Max and it's importance in running. Show Notes: Article on Genes and Trainability of VO2max -  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688475/  Article on Breaking 2 Project Physiology -  https://journals.physiology.org/doi/full/10.1152/japplphysiol.00647.2020?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org  Article on What it Would take to Break a 2hr marathon -  https://journals.physiology.org/doi/full/10.1152/japplphysiol.00563.2010?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org  Article on Marathon Physiology -  https://www.frontiersin.org/articles/10.3389/fcvm.2022.856875/full#B1 

Are you ready for a lil chat about season depression? A li'l seasonal depresh?    Highlights in this episode:  • What is seasonal depression or Seasonal Affective Disorder (S.A.D.)? • About Dr. Norman Rosenthal, the scientist to give this a name • Contributing factors  • Why only certain people get seasonal depression and which factors make it worse • How to cope with mindset and feelings • How to cope with supplements • How to be supportive of friends who experience seasonal depression • The benefits of natural light and artificial "happy lights"   Part 2 is all about the role of vitamin D. There are some surprising factors and fixing seasonal depression is NOT as simple as "just take some vitamin D". That's why it's getting its own episode.    Resources in this episode:  https://www.normanrosenthal.com  https://www.psychiatria-danubina.com/UserDocsImages/pdf/dnb_vol28_no1/dnb_vol28_no1_25.pdf  https://www.psychiatry.org/patients-families/seasonal-affective-disorder  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673349/  https://ajp.psychiatryonline.org/doi/full/10.1176/appi.ajp.162.4.656?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed&    Happy lights recommended by Dr. Rosenthal: https://verilux.com/   https://carex.com/     Red light therapy panels: https://joovv.com/ https://redtherapy.co http://www.clearlightventures.com/ https://bioslighting.com/ https://www.biolight.shop/ https://mitoredlight.com  https://omniluxled.com    FitFizz website:  https://fitfizzstudio.com 

This week we discuss a variety of scientific and preliminary research articles, with a critical perspective on what can be taken from the research and we identify and discuss how the research was conducted. joint smoking research article: https://www.liebertpub.com/doi/10.1089/can.2023.0123?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub+@UCulZrajYO2EnlbfufWU1DnQ john hopkins smoking vs vaping thc uptake in blood: https://www.hopkinsmedicine.org/news/newsroom/news-releases/2018/12/vaping-cannabis-produces-stronger-effects-than-smoking-cannabis-for-infrequent-users side lighting article: https://www.cannabisbusinesstimes.com/news/intercanopy-lighting-research-cannabis/?fbclid=PAAaZi_hBwWyfitOTlnMmiDug2sxAobJ7aYhUgxwB3HC8xS2pveOjl-YGu-0g mycorrhizal fungi article swiss farms: https://www.nature.com/articles/s41564-023-01520-w giberrilins and trichome formation article from very end of the show: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC34957/ This week host @Jackgreenstalk (aka @Jack_Greenstalk on X/instagram backup account) [or contact via email: JackGreenstalk47@gmail.com] is joined by the always amazing panel with @spartangrown on instagram only or email spartangrown@gmail.com for contacting spartan outside social media, any alternate profiles on other social medias using spartan's name, and photos are not actually spartan grown be aware, @drmjcoco from cocoforcannabis.com as well as youtube where he tests and reviews grow lights and has grow tutorials and @drmjcoco on instagram and Matthew Gates aka @SynchAngel on instagram and twitter and @Zenthanol on youtube who offers IPM direct chat for $1 a month on patreon.com/zenthanol ... This week we missed @TheAmericanOne on youtube aka @theamericanone_with_achenes on instagram who's amy aces can be found at amyaces.com, and @Rust.Brandon of @Bokashi Earthworks who's products can be found at bokashiearthworks.com , @NoahtheeGrowa on instagram and @ATG Acres Aaron The Grower aka @atgacres his products can be found at atgacres.com and now has product commercially available in select locations in OK, view his instagram to find out details about drops! --- Support this podcast: https://podcasters.spotify.com/pod/show/cheaphomegrow/support

In this episode, we dive into the management of newly diagnosed and relapsed FLT3-positive AML with Dr. Alexander Perl.Here are the shownotes:1. Assessment of minimal residual disease in standard-risk AML https://www.nejm.org/doi/full/10.1056/nejmoa1507471 2. RATIFY study: Midostaurin plus chemotherapy for AML with a FLT3 mutationhttps://www.nejm.org/doi/full/10.1056/nejmoa1614359 3. QuANTUM-First trial: Quizartinib plus chemotherapy in newly diagnosed patients with FLT3-internal-tandem-duplication-positive acute myeloid leukaemia (QuANTUM-First): a randomised, double-blind, placebo-controlled, phase 3 trialhttps://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)00464-6/fulltext 4. Benefit of high-dose daunorubicin in AML induction extends across cytogenetic and molecular groupshttps://ashpublications.org/blood/article/127/12/1551/35035/Benefit-of-high-dose-daunorubicin-in-AML-induction 5. Prospective Randomized Comparison of Idarubicin and High-Dose Daunorubicin in Induction Chemotherapy for Newly Diagnosed Acute Myeloid Leukemiahttps://ascopubs.org/doi/10.1200/JCO.2017.72.8618?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed 6. Phase 3 trial of gilteritinib plus azacitidine vs. azacitidine for newly diagnosed FLT3mut+ AML ineligible for intensive chemotherapyhttps://ashpublications.org/blood/article/140/17/1845/486088/Phase-3-trial-of-gilteritinib-plus-azacitidine-vs 7. ADMIRAL: Gilteritinib or Chemotherapy for Relapsed or Refractory FLT3-Mutated AMLhttps://www.nejm.org/doi/full/10.1056/nejmoa1902688 8. Venetoclax Plus Gilteritinib for FLT3-Mutated Relapsed/Refractory Acute Myeloid Leukemiahttps://ascopubs.org/doi/10.1200/JCO.22.00602?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed 9. Levis MJ, Hamadani M, Logan B, et al: BMT-CTN 1506 (MORPHO): A randomized trial of the FLT3 inhibitor gilteritinib as post-transplant maintenance for FLT3-ITD AML. EHA 2023 Hybrid Congress. Abstract LB2711. Presented June 11, 2023. 10. Sorafenib maintenance in patients with FLT3-ITD acute myeloid leukaemia undergoing allogeneic haematopoietic stem-cell transplantation: an open-label, multicentre, randomised phase 3 trial https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(20)30455-1/fulltext?dgcid=raven_jbs_etoc_email

Jessica (jessicaoutofthecloset) joins us this week to talk about Dr Maria Montessori and her groundbreaking method for education... More from Jessica Get your tickets for Sci Guys Live in London here! Grab yourself some merch! You can WATCH the podcast over on our YouTube channel Help keep the show running by supporting us on Patreon! If you'd like to see more of us, follow our socials! sciguys.co.uk TikTok Twitter Instagram Facebook If you spot any points that need correcting, head to sciguys.co.uk/corrections Follow the Sci Guys @notcorry / @lukecutforth References & Further Reading Jessica's Montessori Video https://www.youtube.com/watch?v=rX_TVG1DZuc Maria Montessori https://link.springer.com/article/10.1007/s00247-019-04560-9 https://www.newyorker.com/books/under-review/the-miseducation-of-maria-montessori Montessori Studies https://www.bbc.com/future/article/20230131-does-the-montessori-method-actually-work https://pubmed.ncbi.nlm.nih.gov/34899465/ https://www.forbes.com/sites/traversmark/2021/12/28/new-research-highlights-the-long-term-benefits-of-a-montessori-education/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10406168/ Gentle Parenting https://www.independent.co.uk/life-style/health-and-families/feet-tiktok-york-research-itv-b2227851.html https://www.forbes.com/health/family/what-is-gentle-parenting/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10123053/ https://econtent.hogrefe.com/doi/full/10.1024/1422-4917/a000853?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org https://academic.oup.com/pnasnexus/article/2/6/pgad145/7192947

In this Re-Release of Episode 7 on 4/12/23 of the School of Doza podcast, Nurse Doza provides natural energy solutions to listeners. Nurse Doza gives advice on how to boost energy, where to find it, why fatigue might be occurring, and how to better maintain energy. Additionally, she emphasizes the importance of adrenal gland health to achieving genuine energy and provides instructions on how to support these glands.     00:00 Class is in session 04:09 Support adrenal glands for energy. 05:49 Support adrenal glands with B5. 12:30 Boost dopamine production naturally. 17:17 Support dopamine production daily. 24:19 Increase ATP production for energy. 32:00 Boost energy naturally with cold. 34:15 Support your metabolism naturally.   CHECK OUT MSW NUTRITION SUPPLEMENTS USE CODE NURSEDOZA FOR A NICE DISCOUNT https://www.mswnutrition.com/products/?ref=NURSEDOZA   CLASS NOTES:   First way to boost your energy is __support your adrenal glands_______________. Why? They are a hormone factory and their production decreases with age and stress.   The adrenal glands make stress hormones for us to function. “Salt, sugar, sex” (1) Cortisol, dopamine, norepinephrine, aldosterone (1st layer), sex hormones DHEA-most abundant hormone in the body (1) precursor: progesterone, estrogen, cortisol, and testosterone , pregnenolone,    “The adrenal glands play a vital role in the body's fight or flight response. They generate stress hormones that activate physiological adaptations that are necessary to counteract changes in the external environment. (1) Vitamin b5 “Vitamin B5 (VB5), also known as pantothenate or "anti-stress vitamin,"” (2) “Its deficiency leads to reduced cortisol production, increased arthritic pain, myalgia, fatigue, headache, depression, insomnia, and widespread "proinflammatory" effects on the immune-system.” Studies: Anatomy, Abdomen and Pelvis: Adrenal Glands (Suprarenal Glands) https://www.ncbi.nlm.nih.gov/books/NBK482264/ (1) The potential role of B5: A stitch in time and switch in cytokine https://pubmed.ncbi.nlm.nih.gov/31691401/ (2) Second way to boost your energy is __support your dopamine production_______________. Dopamine functions: (1) Memory. Pleasurable reward and motivation. Behavior and cognition. Attention. Sleep and arousal. Mood. Learning. Lactation. Dopamine also: (1) Causes blood vessels to relax (at low doses, it acts as a vasodilator) or constrict (at high doses, it acts as a vasoconstrictor). Increases sodium (salt) and urine removal from your body. Reduces insulin production in your pancreas. Slows gastrointestinal (GI) (gut) content movement and protects your GI lining. Reduces lymphocyte activity in your immune system.   “If you have the right balance of dopamine, you feel: (1) Happy.***** Motivated. Alert.*** Focused.***** If you have a low dopamine level, you might feel: (1) Tired. Unmotivated. Unhappy. You may also have: Memory loss. Mood swings. Sleep problems. Concentration problems. A low sex drive. “Dopamine is known as the “feel-good” hormone. It gives you a sense of pleasure. It also gives you the motivation to do something when you're feeling pleasure.(1)” ***Is this the hormone we should target in depression?*** “Depression is common - one-fourth of the U.S. population will have a depressive episode sometime in life. “(2) **DOES LOW DOPAMINE SOUND LIKE DEPRESSION? “Folate is a water-soluble B-vitamin necessary for the proper biosynthesis of the monoamine neurotransmitters serotonin, epinephrine, and dopamine.” (2)   “Without the participation of 5-MTHF in this process, SAMe and neurotransmitter levels decrease in the cerebrospinal fluid, contributing to the disease process of depression. SAMe supplementation was shown to improve depressive symptoms.” (2) **BLISS** Studies: Dopamine: https://my.clevelandclinic.org/health/articles/22581-dopamine (1) The methylation, neurotransmitter, and antioxidant connections between folate and depression https://pubmed.ncbi.nlm.nih.gov/18950248/ (2) Third way to boost your energy is __regulate your insulin_______________. “If you have type 2 diabetes, your body does not use insulin properly. This is called insulin resistance.” “Diabetes is a problem with your body that causes blood sugar (also called blood glucose) levels to rise higher than normal. This is also called hyperglycemia.” (1) “Things that can make blood sugar rise include: A meal or snack with more food or more carbohydrates than usual Inactivity Side effects of medications Infection or other illness Changes in hormone levels, such as during menstrual periods Stress   Studies: Blood sugar and insulin at work: https://diabetes.org/tools-support/diabetes-prevention/high-blood-sugar (1)   3rd way to boost your energy is to increase your ATP production: “Adenosine triphosphate, also known as ATP, is a molecule that carries energy within cells. It is the main energy currency of the cell,”   “Mitochondria are subcellular self-autonomous organelles primarily responsible for the generation of energy and ATP synthesis. “ (2)   “with age, mitochondria accumulate ROS-induced damage and become dysfunctional. With time, the function of cells declines causing aging and subsequent death.” (2)   Studies: https://biologydictionary.net/atp/ (1) Mitochondrial Aging and Age-Related Dysfunction of Mitochondriahttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003832/(2) Fourth way to boost your energy is _infrared light therapy________________. “this induces activation of signaling pathways that affect cellular metabolism.”(1) “Subsequent experiments demonstrated that isolated mitochondria are sensitive to irradiation with monochromatic light in the red and near-infrared spectrum. For example, illumination of isolated rat liver mitochondria increased adenosine triphosphate (ATP) synthesis and oxygen consumption.” (1) Studies:Low-level light therapy of the eye and brain  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436183/ (1) 5th way to boost your energy is __cold exposure__________________. “In healthy individuals, cold exposure can increase energy expenditure and whole body glucose and fatty acid utilization. Repeated exposures can lower fasting glucose and insulin levels and improve dietary fatty acid handling, even in healthy individuals.” (1) “discovery that human BAT could be stimulated to produce heat and clear circulating substrates upon cold exposure” (1)   “the stimulation of cutaneous cold-sensitive thermoreceptors results in the activation of autonomic and somatic motor responses to limit heat loss to the environment and increase metabolic heat production “ (1)   Studies: Examining the benefits of cold exposure as a therapeutic strategy for obesity and type 2 diabetes https://journals.physiology.org/doi/full/10.1152/japplphysiol.00934.2020?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org (1)  

In this thought-provoking episode, we embark on a scientific journey to unravel the complexities surrounding sodium intake recommendations. In response to a controversial podcast episode that suggested lower sodium intake might be riskier than higher levels, we dive headfirst into the research cited, dissecting the evidence and scrutinizing the claims.Join us as we dissect the prevailing theories, navigate through conflicting data, and critically assess the foundation of current sodium guidelines. Armed with a commitment to uncover the truth, we analyze studies, and explore the nuances of sodium's impact on our health.Prepare to have your understanding challenged and your curiosity piqued as we uncover the layers of scientific knowledge that shape our understanding of sodium intake. From cardiovascular health to cancer and bone health, we're here to set the record straight and provide you with a comprehensive understanding of what the science truly says about sodium.Tune in to "Unmasking the Sodium Debate" and equip yourself with evidence-based insights that can help you make informed choices about your dietary habits and overall well-being.https://youtu.be/sy0UYPnZ_SYwatchsalt-and-sodiumflawed-science-on-sodium-from-jama2154042189966324651634https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7832857/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8030337/https://www.nature.com/articles/pr1981502https://www.ahajournals.org/doi/10.1161/01.cir.52.1.146?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmedhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8955583/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816261/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7056944/

Welcome back to the summer shorts series! Over the summer, the CAR podcast team are bringing you bite-sized episodes on a recently published paper from different members of the team at the Centre for Appearance Research. In this summer short, Abbi speaks with A/Prof Nicola Stock about her recently published paper titled 'Feasibility and Acceptability of the Promoting Resilience in Stress Management-Parent(PRISM-P) Intervention for Caregivers of Children with Craniofacial Conditions'. Read the paper here: https://journals.sagepub.com/doi/10.1177/10556656231157449?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed Episode produced by Abbi Mathews Summer shorts series developed by Nadia Craddock

There are cancers that grow slowly. There are cancers that do not grow at all. And then there are cancer's like today's subject, that are notorious not just for their ability to completely overcome a patient in a very small amount of time. Extensive-stage small cell lung cancer remains a very difficult condition to treat, highly prone to relapse and with few effective options beyond - or perhaps even including - the first line setting. While the medical and scientific community remain stalwart in their quest for therapeutic options, success stories have been few and far between. In this episode, Josh and Michael look at one success story, and one study dredged up from the pre-Internet era, to illustrate the dichotomy and discuss the challenge of treating this, the most aggressive of solid tumours.Links to studies discussed in this episode (subscription may be required):IMpower133: https://www.nejm.org/doi/full/10.1056/nejmoa1809064 von Pawel et al.: https://ascopubs.org/doi/10.1200/JCO.1999.17.2.658?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmedFor more episodes, resources and blog posts, visit www.inquisitiveonc.comFind us on Twitter @InquisitiveOnc!If you want us to look at a specific trial or subject, email us at inquisitiveonc@gmail.comArt courtesy of Taryn SilverMusic courtesy of Music Unlimited: https://pixabay.com/users/music_unlimited-27600023/Disclaimer: This podcast is for educational purposes only. If you are unwell, seek medical advice. Hosted on Acast. See acast.com/privacy for more information.

Foco nos elementos que podem trazer felicidade às pessoas. Alcançar o bem-estar subjetivo. Busca por uma vida prazerosa, engajada e significativa. Podem soar meio místicas, mas são coisas associadas à chamada "psicologia positiva". Existem evidências científicas sobre sua efetividade? Parte 2 de 2.Confira o papo entre o leigo curioso, Ken Fujioka, e o cientista PhD, Altay de Souza.> OUÇA (51min 15s)*Naruhodo! é o podcast pra quem tem fome de aprender. Ciência, senso comum, curiosidades, desafios e muito mais. Com o leigo curioso, Ken Fujioka, e o cientista PhD, Altay de Souza.Edição: Reginaldo Cursino.http://naruhodo.b9.com.br*PARCERIA: ALURAAprofunde-se de vez: garantimos conhecimento com profundidade e diversidade, para se tornar um profissional em T - incluindo programação, front-end, data science, devops, ux & design, mobile, inovação & gestão.Navegue sua carreira: são mais de 1300 cursos e novos lançamentos toda semana, além de atualizações e melhorias constantes.Conteúdo imersivo: faça parte de uma comunidade de apaixonados por tudo que é digital. Mergulhe na comunidade Alura.Aproveite o desconto para ouvintes Naruhodo no link:https://alura.tv/naruhodo*REFERÊNCIASThe psychological roots of intellectual humility: The role of intelligence and cognitive flexibilityhttps://www.sciencedirect.com/science/article/pii/S0191886919300285Authoritarian personality and subjective well-being in Chinese college students: The moderation effect of the organizational culture contexthttps://www.sciencedirect.com/science/article/abs/pii/S0191886918305166Positive Psychology, Ethnocentrism, and the Disguised Ideology ofIndividualismhttps://www.researchgate.net/profile/John-Christopher-13/publication/247743821_Positive_Psychology_Ethnocentrism_and_the_Disguised_Ideology_of_Individualism/links/00b49521169493452a000000/Positive-Psychology-Ethnocentrism-and-the-Disguised-Ideology-of-Individualism.pdfTranscendental Anthropology and Existential Phenomenology of Happinesshttps://link.springer.com/chapter/10.1007/978-3-031-05095-4_2A systems theoretical servant-leadership framework with reference to Christianity and positive psychologyhttps://www.researchgate.net/publication/352218380_A_systems_theoretical_servant-leadership_framework_with_reference_to_Christianity_and_positive_psychologyDon't worry, be happy: Erasing racism, sexism, and poverty in positive psychologyhttps://onlinelibrary.wiley.com/doi/10.1002/ppi.1433POSITIVE PSYCHOLOGY IN RACIAL AND ETHNIC GROUPS: A SECOND CALL TO ACTION!https://www.apa.org/pubs/books/Positive-Psychology-in-Racial-and-Ethnic-Groups-Chapter-1-Sample.pdfPenn's Positive Psychology Center Awards $2.9 Million for Researchhttps://penntoday.upenn.edu/news/penn-s-positive-psychology-center-awards-29-million-research-intersecting-neuroscience-and-posiPursuits of Happinesshttps://books.google.com.br/books?hl=en&lr=&id=oaroeDGkUwcC&oi=fnd&pg=PP1&dq=anthropology+of+happiness&ots=L7BGi1kRlX&sig=-yFZQ2MoZHJ1Yo8BySAV8MBLy2Y&redir_esc=y#v=onepage&q=anthropology%20of%20happiness&f=falseFlawed Self-Assessment: Implications for Health, Education, and the Workplacehttps://journals.sagepub.com/doi/full/10.1111/j.1529-1006.2004.00018.xThe Paranoid Optimist: An Integrative Evolutionary Model of Cognitive Biases.https://journals.sagepub.com/doi/10.1207/s15327957pspr1001_3?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmedDo Moderators of the Optimistic Bias Affect Personal or Target Risk Estimates? A Review of the Literaturehttps://journals.sagepub.com/doi/abs/10.1207/S15327957PSPR0501_5Optimism and Wishful Thinking: Consistency Across Populations inChildren's Expectations for the Futurehttp://srcd.onlinelibrary.wiley.com.sci-hub.tw/doi/abs/10.1111/cdev.13293Positive Psychology: A Personal Historyhttps://www.annualreviews.org/doi/full/10.1146/annurev-clinpsy-050718-095653Bhutan's Gross National Happiness Indexhttps://web.archive.org/web/20200424163506/https://ophi.org.uk/policy/national-policy/gross-national-happiness-index/GNH ´s Pilot Project in Brazilhttps://www.youtube.com/watch?v=FPeNwH3ax-cRyan, R. M., Huta, V., & Deci, E. L. (2006). Living well: a self-determination theory perspective on eudaimonia. Journal of Happiness Studies, 9(1), 139–170. doi:10.1007/s10902-006-9023-4 http://link.springer.com.sci-hub.tw/article/10.1007/s10902-006-9023-4Lee Duckworth, A., Steen, T. A., & Seligman, M. E. P. (2005). Positive Psychology in Clinical Practice. Annual Review of Clinical Psychology, 1(1), 629–651. doi:10.1146/annurev.clinpsy.1.102803.144154 http://www.annualreviews.org.sci-hub.tw/doi/pdf/10.1146/annurev.clinpsy.1.102803.144154Coaching and positive psychologyhttp://www.positiveinsights.co.uk/articles/Coaching_Positive_Psychology.pdfPositive Psychology ProgressEmpirical Validation of Interventionshttps://pdfs.semanticscholar.org/e83e/c1739d233acebe78d5df0b56b2c6f6f42691.pdfMotivation and Personality - Maslowhttps://www.eyco.org/nuovo/wp-content/uploads/2016/09/Motivation-and-Personality-A.H.Maslow.pdfAggression as successful self-controlhttps://compass.onlinelibrary.wiley.com/doi/10.1111/spc3.12832The critiques and criticisms of positive psychology: A systematic reviewhttps://www.tandfonline.com/doi/full/10.1080/17439760.2023.2178956Naruhodo #346 - Programação Neurolinguística (PNL) tem base científica? - Parte 1 de 2https://www.youtube.com/watch?v=p9-iauANzY0Naruhodo #347 - Programação Neurolinguística (PNL) tem base científica? - Parte 2 de 2https://www.youtube.com/watch?v=yggQXOE9lRYNaruhodo #363 - Jejum de dopamina funciona?https://www.youtube.com/watch?v=908qoFZG8rYNaruhodo #387 - Somos bons (ou maus) por natureza? - Parte 1 de 2https://www.youtube.com/watch?v=Fx37e0PUgY4Naruhodo #388 - Somos bons (ou maus) por natureza? - Parte 2 de 2https://www.youtube.com/watch?v=xwAEaMyfm0QNaruhodo #252 - A pirâmide de Maslow faz sentido?https://www.youtube.com/watch?v=ZtmxN--tVRYNaruhodo #306 - Sentir gratidão faz bem pra saúde?https://www.youtube.com/watch?v=Trx6S76yCZkNaruhodo #26 - Meditação faz bem pra saúde, segundo a ciência?https://www.youtube.com/watch?v=cqzZlXHtxjkNaruhodo #311 - O apego mãe-bebê é algo inato?https://www.youtube.com/watch?v=vkcIZBPNOQgNaruhodo #342 - O que é e de onde vem a inspiração?https://www.youtube.com/watch?v=Xg0vGC-uPwMNaruhodo #340 - Como se constrói a auto-estima?https://www.youtube.com/watch?v=0ULx-CXmh7wNaruhodo #366 - Por que temos ideias durante o banho?https://www.youtube.com/watch?v=jYJUwNRZWHE*APOIE O NARUHODO PELA PLATAFORMA ORELO!Um aviso importantíssimo: o podcast Naruhodo agora está no Orelo: https://bit.ly/naruhodo-no-oreloE é por meio dessa plataforma de apoio aos criadores de conteúdo que você ajuda o Naruhodo a se manter no ar.Você escolhe um valor de contribuição mensal e tem acesso a conteúdos exclusivos, conteúdos antecipados e vantagens especiais.Além disso, você pode ter acesso ao nosso grupo fechado no Telegram, e conversar comigo, com o Altay e com outros apoiadores.E não é só isso: toda vez que você ouvir ou fizer download de um episódio pelo Orelo, vai também estar pingando uns trocadinhos para o nosso projeto.Então, baixe agora mesmo o app Orelo no endereço Orelo.CC ou na sua loja de aplicativos e ajude a fortalecer o conhecimento científico.https://bit.ly/naruhodo-no-orelo

Foco nos elementos que podem trazer felicidade às pessoas. Alcançar o bem-estar subjetivo. Busca por uma vida prazerosa, engajada e significativa. Podem soar meio místicas, mas são coisas associadas à chamada "psicologia positiva". Existem evidências científicas sobre sua efetividade? Parte 1 de 2.Confira o papo entre o leigo curioso, Ken Fujioka, e o cientista PhD, Altay de Souza.> OUÇA (58min 36s)*Naruhodo! é o podcast pra quem tem fome de aprender. Ciência, senso comum, curiosidades, desafios e muito mais. Com o leigo curioso, Ken Fujioka, e o cientista PhD, Altay de Souza.Edição: Reginaldo Cursino.http://naruhodo.b9.com.br*PARCERIA: ALURAAprofunde-se de vez: garantimos conhecimento com profundidade e diversidade, para se tornar um profissional em T - incluindo programação, front-end, data science, devops, ux & design, mobile, inovação & gestão.Navegue sua carreira: são mais de 1300 cursos e novos lançamentos toda semana, além de atualizações e melhorias constantes.Conteúdo imersivo: faça parte de uma comunidade de apaixonados por tudo que é digital. Mergulhe na comunidade Alura.Aproveite o desconto para ouvintes Naruhodo no link:https://alura.tv/naruhodo*REFERÊNCIASThe psychological roots of intellectual humility: The role of intelligence and cognitive flexibilityhttps://www.sciencedirect.com/science/article/pii/S0191886919300285Authoritarian personality and subjective well-being in Chinese college students: The moderation effect of the organizational culture contexthttps://www.sciencedirect.com/science/article/abs/pii/S0191886918305166Positive Psychology, Ethnocentrism, and the Disguised Ideology ofIndividualismhttps://www.researchgate.net/profile/John-Christopher-13/publication/247743821_Positive_Psychology_Ethnocentrism_and_the_Disguised_Ideology_of_Individualism/links/00b49521169493452a000000/Positive-Psychology-Ethnocentrism-and-the-Disguised-Ideology-of-Individualism.pdfTranscendental Anthropology and Existential Phenomenology of Happinesshttps://link.springer.com/chapter/10.1007/978-3-031-05095-4_2A systems theoretical servant-leadership framework with reference to Christianity and positive psychologyhttps://www.researchgate.net/publication/352218380_A_systems_theoretical_servant-leadership_framework_with_reference_to_Christianity_and_positive_psychologyDon't worry, be happy: Erasing racism, sexism, and poverty in positive psychologyhttps://onlinelibrary.wiley.com/doi/10.1002/ppi.1433POSITIVE PSYCHOLOGY IN RACIAL AND ETHNIC GROUPS: A SECOND CALL TO ACTION!https://www.apa.org/pubs/books/Positive-Psychology-in-Racial-and-Ethnic-Groups-Chapter-1-Sample.pdfPenn's Positive Psychology Center Awards $2.9 Million for Researchhttps://penntoday.upenn.edu/news/penn-s-positive-psychology-center-awards-29-million-research-intersecting-neuroscience-and-posiPursuits of Happinesshttps://books.google.com.br/books?hl=en&lr=&id=oaroeDGkUwcC&oi=fnd&pg=PP1&dq=anthropology+of+happiness&ots=L7BGi1kRlX&sig=-yFZQ2MoZHJ1Yo8BySAV8MBLy2Y&redir_esc=y#v=onepage&q=anthropology%20of%20happiness&f=falseFlawed Self-Assessment: Implications for Health, Education, and the Workplacehttps://journals.sagepub.com/doi/full/10.1111/j.1529-1006.2004.00018.xThe Paranoid Optimist: An Integrative Evolutionary Model of Cognitive Biases.https://journals.sagepub.com/doi/10.1207/s15327957pspr1001_3?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmedDo Moderators of the Optimistic Bias Affect Personal or Target Risk Estimates? A Review of the Literaturehttps://journals.sagepub.com/doi/abs/10.1207/S15327957PSPR0501_5Optimism and Wishful Thinking: Consistency Across Populations inChildren's Expectations for the Futurehttp://srcd.onlinelibrary.wiley.com.sci-hub.tw/doi/abs/10.1111/cdev.13293Positive Psychology: A Personal Historyhttps://www.annualreviews.org/doi/full/10.1146/annurev-clinpsy-050718-095653Bhutan's Gross National Happiness Indexhttps://web.archive.org/web/20200424163506/https://ophi.org.uk/policy/national-policy/gross-national-happiness-index/GNH ´s Pilot Project in Brazilhttps://www.youtube.com/watch?v=FPeNwH3ax-cRyan, R. M., Huta, V., & Deci, E. L. (2006). Living well: a self-determination theory perspective on eudaimonia. Journal of Happiness Studies, 9(1), 139–170. doi:10.1007/s10902-006-9023-4 http://link.springer.com.sci-hub.tw/article/10.1007/s10902-006-9023-4Lee Duckworth, A., Steen, T. A., & Seligman, M. E. P. (2005). Positive Psychology in Clinical Practice. Annual Review of Clinical Psychology, 1(1), 629–651. doi:10.1146/annurev.clinpsy.1.102803.144154 http://www.annualreviews.org.sci-hub.tw/doi/pdf/10.1146/annurev.clinpsy.1.102803.144154Coaching and positive psychologyhttp://www.positiveinsights.co.uk/articles/Coaching_Positive_Psychology.pdfPositive Psychology ProgressEmpirical Validation of Interventionshttps://pdfs.semanticscholar.org/e83e/c1739d233acebe78d5df0b56b2c6f6f42691.pdfMotivation and Personality - Maslowhttps://www.eyco.org/nuovo/wp-content/uploads/2016/09/Motivation-and-Personality-A.H.Maslow.pdfAggression as successful self-controlhttps://compass.onlinelibrary.wiley.com/doi/10.1111/spc3.12832The critiques and criticisms of positive psychology: A systematic reviewhttps://www.tandfonline.com/doi/full/10.1080/17439760.2023.2178956Naruhodo #346 - Programação Neurolinguística (PNL) tem base científica? - Parte 1 de 2https://www.youtube.com/watch?v=p9-iauANzY0Naruhodo #347 - Programação Neurolinguística (PNL) tem base científica? - Parte 2 de 2https://www.youtube.com/watch?v=yggQXOE9lRYNaruhodo #363 - Jejum de dopamina funciona?https://www.youtube.com/watch?v=908qoFZG8rYNaruhodo #387 - Somos bons (ou maus) por natureza? - Parte 1 de 2https://www.youtube.com/watch?v=Fx37e0PUgY4Naruhodo #388 - Somos bons (ou maus) por natureza? - Parte 2 de 2https://www.youtube.com/watch?v=xwAEaMyfm0QNaruhodo #252 - A pirâmide de Maslow faz sentido?https://www.youtube.com/watch?v=ZtmxN--tVRYNaruhodo #306 - Sentir gratidão faz bem pra saúde?https://www.youtube.com/watch?v=Trx6S76yCZkNaruhodo #26 - Meditação faz bem pra saúde, segundo a ciência?https://www.youtube.com/watch?v=cqzZlXHtxjkNaruhodo #311 - O apego mãe-bebê é algo inato?https://www.youtube.com/watch?v=vkcIZBPNOQgNaruhodo #342 - O que é e de onde vem a inspiração?https://www.youtube.com/watch?v=Xg0vGC-uPwMNaruhodo #340 - Como se constrói a auto-estima?https://www.youtube.com/watch?v=0ULx-CXmh7wNaruhodo #366 - Por que temos ideias durante o banho?https://www.youtube.com/watch?v=jYJUwNRZWHE*APOIE O NARUHODO PELA PLATAFORMA ORELO!Um aviso importantíssimo: o podcast Naruhodo agora está no Orelo: https://bit.ly/naruhodo-no-oreloE é por meio dessa plataforma de apoio aos criadores de conteúdo que você ajuda o Naruhodo a se manter no ar.Você escolhe um valor de contribuição mensal e tem acesso a conteúdos exclusivos, conteúdos antecipados e vantagens especiais.Além disso, você pode ter acesso ao nosso grupo fechado no Telegram, e conversar comigo, com o Altay e com outros apoiadores.E não é só isso: toda vez que você ouvir ou fizer download de um episódio pelo Orelo, vai também estar pingando uns trocadinhos para o nosso projeto.Então, baixe agora mesmo o app Orelo no endereço Orelo.CC ou na sua loja de aplicativos e ajude a fortalecer o conhecimento científico.https://bit.ly/naruhodo-no-orelo

Dr. Ralph W. Moss and son Ben discuss how a walk in the woods may help manage symptoms and improve quality of life. Delve into the science behind how forest bathing and aromatherapy can reduce stress, improve mood, and ease pain.  Program Notes: Recommended Product NOW Woodland Walk essential oil https://www.nowfoods.com/products/essential-oils/woodland-walk-oil-blend   For more information on cancer-fighting foods and supplements, please visit our website: https://www.themossreport.com   5 Defenders Mushroom Blend https://shop.realmushrooms.com/products/organic-mushroom-blend-capsules?ref=391 “A comprehensive self-help plan for cancer includes medicinal mushrooms. They are indispensable”. – Ralph W. Moss, PhD For Dr. Moss' recommended products list, please visit https://www.themossreport.com/recommended-products/ How to use reed diffusers https://www.harlemcandlecompany.com/blogs/journal/how-to-use-reed-diffusers-everything-you-need-to-know Tips on diluting essential oils with carrier oils https://essentials.banyantree.com/blogs/blog/how-to-dilute-essential-oils#:~:text=Is%20dilution%20always%20necessary%3F,and%20model%20of%20diffuser%20differs The Tisserand Academy (of Aromatherapy) of Robert and Hana Tisserand https://roberttisserand.com/ Articles cited: Aromatherapy as an adjuvant treatment in cancer care--a descriptive systematic review. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3746639/ Efficacy of Essential Oils in Relieving Cancer Pain: A Systematic Review and Meta-Analysis. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138439/ Visiting a forest, but not a city, increases human natural killer activity and expression of anti-cancer proteins. https://journals.sagepub.com/doi/10.1177/039463200802100113?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed Effects of forest environment (Shinrin-yoku/Forest bathing) on health promotion and disease prevention -the Establishment of "Forest Medicine" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9665958/ Enhancing Cytotoxicity of Tamoxifen Using Geranium Oil. Evid Based Complement https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8942665/ A Randomized Controlled Trial for the Effectiveness of Aromatherapy in Decreasing Salivary Gland Damage following Radioactive Iodine Therapy for Differentiated Thyroid Cancer. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5155074/ The physiological effects of Shinrin-yoku (taking in the forest atmosphere or forest bathing): evidence from field experiments in 24 forests across Japan https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2793346/ Anti-inflammatory and anti-cancer activities of essential oils and their biological constituents. https://www.dustri.com/nc/article-response-page.html?artId=8281&doi= Olfactory stimulation modulates the blood glucose level in rats. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820856/

In this podcast, Nurse Doza provides tips for recovering from a night of drinking. He suggests taking a multivitamin, especially one with electrolytes and trace minerals, to help replenish the vital nutrients alcohol has depleted. He also recommends avoiding caffeine to help the hangover go away and encourages listeners to invest in their health by joining his webinar   TIMESTAMPS: 00:00 Start 02:13 Replenish vital nutrients after drinking. 05:20 Replenish liver with key nutrients. 11:19 Take liver detox supplements. 19:40 Get restful sleep for recovery. 20:18 Prepare for healthy sleep. 25:45 Pre-tox before drinking.    SHOP MSW & LIVER LOVE HERE https://www.mswnutrition.com/discount/NURSEDOZA?ref=NURSEDOZA   REFERENCES: Studies: https://www.ncbi.nlm.nih.gov/books/NBK548710/(1) https://www.journal-of-hepatology.eu/article/S0168-8278(22)02932-4/fulltext(2)  https://www.sciencedaily.com/releases/2022/08/220805091251.htm(3)  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861788/(4)  https://www.jle.com/fr/revues/mrh/e-docs/magnesium_homeostasis_and_alcohol_consumption_279741/article.phtml(5) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400835/(6) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6490252/(7)  https://journals.physiology.org/doi/full/10.1152/jappl.1997.83.4.1152?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org(8)  https://www.pnas.org/doi/10.1073/pnas.112336399(9)   https://www.ncbi.nlm.nih.gov/books/NBK548710/(1) https://pubmed.ncbi.nlm.nih.gov/1452945/(2)  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470839/(3)  https://pubmed.ncbi.nlm.nih.gov/11368579/(4)  https://pubmed.ncbi.nlm.nih.gov/30019966/(1)  https://pubmed.ncbi.nlm.nih.gov/32808029/(2)  https://www.nature.com/articles/s41598-021-92676-0 (3)  https://pubmed.ncbi.nlm.nih.gov/27603810/(4)  https://www.nature.com/articles/srep29743(5)  https://www.mountsinai.org/health-library/supplement/betaine(6) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266414/(7)  https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0150440(8)  https://pubmed.ncbi.nlm.nih.gov/23232418/(9)  https://www.pnas.org/doi/10.1073/pnas.112336399(10)  https://www.sleepfoundation.org/nutrition/alcohol-and-sleep (1) https://pubmed.ncbi.nlm.nih.gov/10840864/ (2)  https://pubmed.ncbi.nlm.nih.gov/23051584/(3) https://www.sciencedirect.com/science/article/pii/S0013935118300355(4)   https://pubmed.ncbi.nlm.nih.gov/32419511/(5)  https://pubmed.ncbi.nlm.nih.gov/33106037/(6)

De novo metastatic breast cancer represents 6% of all new breast cancer diagnoses. This figure has not changed at all over the past 20 years; however, systemic therapy options have evolved dramatically during this time and have significantly increased life expectancy for these patients. While surgical management of the primary tumor in the setting of metastatic disease has typically been reserved for palliative indications, surgeons are now being asked to consider resecting the primary tumor to potentially increase overall survival. In this episode, we will use a case study to examine the data that should inform our conversations and decisions when we encounter patients with metastatic breast cancer who are interested in having their primary tumor resected. Links: Khan, S.A., S. Schuetz, and O. Hosseini (2022). Primary-Site Local Therapy for Patients with De Novo Metastatic Breast Cancer: An Educational Review. Ann Surg Oncol; 29: 5811-5820. https://link.springer.com/article/10.1245/s10434-022-11900-x Khan, S.A. et al (2022). Early Local Therapy for the Primary Site in De Novo Stage IV Breast Cancer: Results of a Randomized Clinical Trial (E2108). J Clin Oncol; 40(9): 978-987. https://ascopubs.org/doi/10.1200/JCO.21.02006?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed Badwe, R. et al (2015). Locoregional treatment versus no treatment of the primary tumor in metastatic breast cancer: an open-label randomized controlled trial. Lancet Oncol; 16: 1380-1388. https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(15)00135-7/fulltext Fitzal, F. et al (2019). Impact of Breast Surgery in Primary Metastasized Breast Cancer: Outcomes of the Prospective Randomized Phase III ABCSG-28 POSYTIVE Trial. Ann Surg; 269(6): 1163-1169. https://journals.lww.com/annalsofsurgery/Abstract/2019/06000/Impact_of_Breast_Surgery_in_Primary_Metastasized.24.aspx Soran, A. et al (2018). Randomized Trial Comparing Resection of Primary Tumor with No Surgery in Stage IV Breast Cancer at Presentation: Protocol MF07-01. Ann Surg Oncol; 25: 3141-3149. https://link.springer.com/article/10.1245/s10434-018-6494-6 Please visit https://behindtheknife.org to access other high-yield surgical education podcasts, videos and more.   If you liked this episode, check out other breast surgery episodes here: https://behindtheknife.org/podcast-category/breast/

After 4 years of Sci Guys we're tackling our biggest topic yet! This week we're asking whether race exist biologically or is it just a social construct? So strap in & get ready for decades of nonsense to be debunked! Grab yourself some merch! You can WATCH the podcast over on our YouTube channel Help keep the show running by supporting us on Patreon! If you'd like to see more of us, follow our socials! sciguys.co.uk TikTok Twitter Instagram Facebook If you spot any points that need correcting, head to sciguys.co.uk/corrections References & Further Reading Race & Ethnicity Basics https://www.britannica.com/topic/race-human https://www.genome.gov/genetics-glossary/Race https://www.nationalgeographic.com/culture/article/race-ethnicity History of Race https://psycnet.apa.org/fulltext/2005-00117-003.pdf?auth_token=699db5b1de2c85afbddc7ac7066bc2424224ef56 Scientific Racism https://library.harvard.edu/confronting-anti-black-racism/scientific-racism https://www.npr.org/sections/codeswitch/2019/07/10/416496218/is-race-science-making-a-comeback https://www.smithsonianmag.com/science-nature/disturbing-resilience-scientific-racism-180972243/ https://www.nature.com/articles/d41586-019-02244-w Species & Taxonomy https://www.nature.com/scitable/definition/species-312/#:~:text=A%20biological%20species%20is%20a,nature%20and%20produce%20fertile%20offspring. https://en.wikipedia.org/wiki/Taxonomic_rank#/media/File:Taxonomic_Rank_Graph.svg https://www.britannica.com/animal/dog/Related-canids https://www.britannica.com/topic/Neanderthal/Neanderthal-classification Race & Genetics https://www.nature.com/articles/ng1435 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604262/ https://www.theatlantic.com/science/archive/2018/04/reich-genetics-racism/558818/ https://www.discovermagazine.com/planet-earth/race-is-real-but-its-not-genetic https://www.science.org/doi/10.1126/science.aac4951?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed https://science.howstuffworks.com/life/genetic/people-bananas-share-dna.htm#:~:text=About%2060%20percent%20of%20our,the%20banana%2C%22%20Brody%20adds. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4037248/ Race as a Social Construct https://www.scientificamerican.com/article/race-is-a-social-construct-scientists-argue/ https://www.pbs.org/race/000_About/002_04-background-01-07.htm https://www.oxfordreference.com/display/10.1093/oi/authority.20110803100515181;jsessionid=7230B73AAF4E7C31C72AF1CA7E2DE2E7 Race in Research https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3808769/ Follow the SCI GUYS @notcorry / @lukecutforth

This episode of the School of Doza podcast provides natural energy solutions to listeners. Nurse Doza gives advice on how to boost energy, where to find it, why fatigue might be occurring, and how to better maintain energy. Additionally, she emphasizes the importance of adrenal gland health to achieving genuine energy and provides instructions on how to support these glands.     00:00 Class is in session 04:09 Support adrenal glands for energy. 05:49 Support adrenal glands with B5. 12:30 Boost dopamine production naturally. 17:17 Support dopamine production daily. 24:19 Increase ATP production for energy. 32:00 Boost energy naturally with cold. 34:15 Support your metabolism naturally.   CHECK OUT MSW NUTRITION SUPPLEMENTS USE CODE NURSEDOZA FOR A NICE DISCOUNT https://www.mswnutrition.com/products/?ref=NURSEDOZA   CLASS NOTES:   First way to boost your energy is __support your adrenal glands_______________. Why? They are a hormone factory and their production decreases with age and stress.   The adrenal glands make stress hormones for us to function. “Salt, sugar, sex” (1) Cortisol, dopamine, norepinephrine, aldosterone (1st layer), sex hormones DHEA-most abundant hormone in the body (1) precursor: progesterone, estrogen, cortisol, and testosterone , pregnenolone,    “The adrenal glands play a vital role in the body's fight or flight response. They generate stress hormones that activate physiological adaptations that are necessary to counteract changes in the external environment. (1) Vitamin b5 “Vitamin B5 (VB5), also known as pantothenate or "anti-stress vitamin,"” (2) “Its deficiency leads to reduced cortisol production, increased arthritic pain, myalgia, fatigue, headache, depression, insomnia, and widespread "proinflammatory" effects on the immune-system.” Studies: Anatomy, Abdomen and Pelvis: Adrenal Glands (Suprarenal Glands) https://www.ncbi.nlm.nih.gov/books/NBK482264/ (1) The potential role of B5: A stitch in time and switch in cytokine https://pubmed.ncbi.nlm.nih.gov/31691401/ (2) Second way to boost your energy is __support your dopamine production_______________. Dopamine functions: (1) Memory. Pleasurable reward and motivation. Behavior and cognition. Attention. Sleep and arousal. Mood. Learning. Lactation. Dopamine also: (1) Causes blood vessels to relax (at low doses, it acts as a vasodilator) or constrict (at high doses, it acts as a vasoconstrictor). Increases sodium (salt) and urine removal from your body. Reduces insulin production in your pancreas. Slows gastrointestinal (GI) (gut) content movement and protects your GI lining. Reduces lymphocyte activity in your immune system.   “If you have the right balance of dopamine, you feel: (1) Happy.***** Motivated. Alert.*** Focused.***** If you have a low dopamine level, you might feel: (1) Tired. Unmotivated. Unhappy. You may also have: Memory loss. Mood swings. Sleep problems. Concentration problems. A low sex drive. “Dopamine is known as the “feel-good” hormone. It gives you a sense of pleasure. It also gives you the motivation to do something when you're feeling pleasure.(1)” ***Is this the hormone we should target in depression?*** “Depression is common - one-fourth of the U.S. population will have a depressive episode sometime in life. “(2) **DOES LOW DOPAMINE SOUND LIKE DEPRESSION? “Folate is a water-soluble B-vitamin necessary for the proper biosynthesis of the monoamine neurotransmitters serotonin, epinephrine, and dopamine.” (2)   “Without the participation of 5-MTHF in this process, SAMe and neurotransmitter levels decrease in the cerebrospinal fluid, contributing to the disease process of depression. SAMe supplementation was shown to improve depressive symptoms.” (2) **BLISS** Studies: Dopamine: https://my.clevelandclinic.org/health/articles/22581-dopamine (1) The methylation, neurotransmitter, and antioxidant connections between folate and depression https://pubmed.ncbi.nlm.nih.gov/18950248/ (2) Third way to boost your energy is __regulate your insulin_______________. “If you have type 2 diabetes, your body does not use insulin properly. This is called insulin resistance.” “Diabetes is a problem with your body that causes blood sugar (also called blood glucose) levels to rise higher than normal. This is also called hyperglycemia.” (1) “Things that can make blood sugar rise include: A meal or snack with more food or more carbohydrates than usual Inactivity Side effects of medications Infection or other illness Changes in hormone levels, such as during menstrual periods Stress   Studies: Blood sugar and insulin at work: https://diabetes.org/tools-support/diabetes-prevention/high-blood-sugar (1)   3rd way to boost your energy is to increase your ATP production: “Adenosine triphosphate, also known as ATP, is a molecule that carries energy within cells. It is the main energy currency of the cell,”   “Mitochondria are subcellular self-autonomous organelles primarily responsible for the generation of energy and ATP synthesis. “ (2)   “with age, mitochondria accumulate ROS-induced damage and become dysfunctional. With time, the function of cells declines causing aging and subsequent death.” (2)   Studies: https://biologydictionary.net/atp/ (1) Mitochondrial Aging and Age-Related Dysfunction of Mitochondriahttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003832/(2) Fourth way to boost your energy is _infrared light therapy________________. “this induces activation of signaling pathways that affect cellular metabolism.”(1) “Subsequent experiments demonstrated that isolated mitochondria are sensitive to irradiation with monochromatic light in the red and near-infrared spectrum. For example, illumination of isolated rat liver mitochondria increased adenosine triphosphate (ATP) synthesis and oxygen consumption.” (1) Studies:Low-level light therapy of the eye and brain  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436183/ (1) 5th way to boost your energy is __cold exposure__________________. “In healthy individuals, cold exposure can increase energy expenditure and whole body glucose and fatty acid utilization. Repeated exposures can lower fasting glucose and insulin levels and improve dietary fatty acid handling, even in healthy individuals.” (1) “discovery that human BAT could be stimulated to produce heat and clear circulating substrates upon cold exposure” (1)   “the stimulation of cutaneous cold-sensitive thermoreceptors results in the activation of autonomic and somatic motor responses to limit heat loss to the environment and increase metabolic heat production “ (1)   Studies: Examining the benefits of cold exposure as a therapeutic strategy for obesity and type 2 diabetes https://journals.physiology.org/doi/full/10.1152/japplphysiol.00934.2020?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org (1)

Diets, coronary artery calcium, statins, basic CAD knowledge, and AF ablation are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I. Diet Some Diets Better Than Others for Heart Protection https://www.medscape.com/viewarticle/990305 - Comparison of seven popular structured dietary programmes and risk of mortality and major cardiovascular events in patients at increased cardiovascular risk: systematic review and network meta-analysis https://doi.org/10.1136/bmj-2022-072003 Plant-Based Diets Not Always Healthy; Quality Is Key https://www.medscape.com/viewarticle/990178 - Association of Healthful Plant-based Diet Adherence With Risk of Mortality and Major Chronic Diseases Among Adults in the UK https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2802814 II. CAC and Statins - Using the Coronary Artery Calcium Score to Guide Statin Therapy https://www.ahajournals.org/doi/full/10.1161/CIRCOUTCOMES.113.000799 III. Subclinical Atherosclerosis Subclinical CAD by CT Predicts MI Risk, With or Without Stenoses https://www.medscape.com/viewarticle/990254 - Subclinical Coronary Atherosclerosis and Risk for Myocardial Infarction in a Danish Cohort A Prospective Observational Cohort Study 0799 https://www.acpjournals.org/doi/10.7326/M22-3027 - A Prospective Natural-History Study of Coronary Atherosclerosis https://www.nejm.org/doi/10.1056/NEJMoa1002358?url_ver=Z39.88-2003 IV. AF ablation - Standard vs Augmented Ablation of Paroxysmal Atrial Fibrillation for Reduction of Atrial Fibrillation RecurrenceThe AWARE Randomized Clinical Trial https://jamanetwork.com/journals/jamacardiology/fullarticle/2802860 - Effect of Catheter Ablation Using Pulmonary Vein Isolation With vs Without Posterior Left Atrial Wall Isolation on Atrial Arrhythmia Recurrence in Patients With Persistent Atrial FibrillationThe CAPLA Randomized Clinical Trial https://jamanetwork.com/journals/jama/article-abstract/2800186 - Approaches to Catheter Ablation for Persistent Atrial Fibrillation https://www.nejm.org/doi/full/10.1056/NEJMoa1408288 You may also like: Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine. https://www.medscape.com/features/public/machine The Bob Harrington Show with Stanford University Chair of Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net

Episode 2 of Pharmanipulation invites Adewole S. Adamson MD, MPP, to discuss the relationship of sun exposure to melanoma, whether sunscreen actually prevents skin cancer, and the overdiagnosis of melanoma. Dr. Adamson is a board-certified dermatologist and an assistant professor in the department of Internal Medicine at Dell Medical School at the University of Texas at Austin where he studies skin cancer, evidence-based medicine, and health policy. He is also the Director of the Pigmented Lesion Clinic at the University of Texas at Austin, and he serves as an assistant editor at JAMA Dermatology. Pharmanipulation is produced by PharmedOut, a Georgetown University Medical Center rational prescribing project. For a transcript of this episode, please visit: https://georgetown.box.com/s/3bte8vynpulj33kv3qdtwdabamm2n9xx To learn more about Dr. Adamson, please visit his website: https://adeadamson.com/ Dr. Adamson's paper on Estimating Overdiagnosis of Melanoma Using Trends Among Black and White Patients in the U.S. is available here: https://jamanetwork.com/journals/jamadermatology/fullarticle/2789995 Dr. Adamson's paper on The Rapid Rise in Cutaneous Melanoma Diagnoses is available here: https://www.nejm.org/doi/10.1056/NEJMsb2019760?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed PharmedOut is supported primarily by individual donations. To make a donation please visit: https://sites.google/com/georgetown.edu/pharmedout/donate

Third-year OHSU medical students, Candace Chan and Devon Boorstein-Holler rehash the information from our first sleep medicine & psychiatry talk in a question-and-answer format. This episode is part of a project to help determine optimal podcast formats for student learning. Hosted by: Devon Boorstein-Holler, MS3 & Candace Chan, MS3 Questions? psychiatryexplored@gmail.com Studies Mentioned: Overview on the pharmacology of sleep: https://aasm.org/resources/pdf/pharmacologictreatmentofinsomnia.pdf Study on melatonin in OTC: https://jcsm.aasm.org/doi/full/10.5664/jcsm.6434 NEJM Bob Sack review melatonin for jet lag: https://www.nejm.org/doi/10.1056/NEJMcp0909838?url_ver=Z39.88-%202003&rft_id=ori:rid:crossref.org&rfr_dat-cr_pub%20%200pubmed Study on two groups with insomnia or not, odds to develop depression: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108260/ Resource for online CBTI: https://www.sleepfoundation.org/insomnia/treatment/cognitive-behavioral-therapy-insomnia CBTI for depression: https://academic.oup.com/sleep/article/31/4/489/2454177?login=true IRT vs. IRT+CBT vs. Prazosin: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4265653/

Study showing the time from diagnosis of AML to the start of intensive treatment indicate that a treatment delay has no negative prognostic impact. https://ashpublications.org/blood/article/136/7/823/460669/Does-time-from-diagnosis-to-treatment-affect-the RATIFY clinical trial showing the addition of midostaurin (FLT3 inhibitor) to 7+3 chemotherapy for AML https://www.nejm.org/doi/full/10.1056/nejmoa1614359 Diagnosis and management of AML in adults: 2022 recommendations from an international expert panel on behalf of the European LeukemiaNet (ELN) https://ashpublications.org/blood/article/140/12/1345/485817/Diagnosis-and-management-of-AML-in-adults-2022 ASH 2022 abstract presenting Daunorubicin 60 Vs 90 mg/m2 https://ash.confex.com/ash/2022/webprogram/Paper157126.html ALFA-0701. The addition of gemtuzumab ozogamicin, an anti-CD33 antibody conjugate, to the standard treatment for patients with acute myeloid leukemiahttps://www.thelancet.com/article/S0140-6736(12)60485-1/fulltext Quizartinib data presented at EHA 2022 https://library.ehaweb.org/eha/2022/eha2022-congress/356965/harry.erba.quizartinib.prolonged.survival.vs.placebo.plus.intensive.induction.html?f=menu%3D6%2Abrowseby%3D8%2Asortby%3D2%2Amedia%3D3%2Ace_id%3D2233%2Amarker%3D1749%2Afeatured%3D17676 International Consensus Classification (ICC) of Myeloid Neoplasms and Acute Leukemiashttps://ashpublications.org/blood/article/140/11/1200/485730/International-Consensus-Classification-of-Myeloid The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasmshttps://www.nature.com/articles/s41375-022-01613-1  CPX-351 (cytarabine and daunorubicin) Liposome for Injection Versus Conventional Cytarabine Plus Daunorubicin in Older Patients With Newly Diagnosed Secondary Acute Myeloid Leukemiahttps://ascopubs.org/doi/10.1200/JCO.2017.77.6112?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed  Oral Azacitidine Maintenance Therapy for Acute Myeloid Leukemia in First Remissionhttps://www.nejm.org/doi/full/10.1056/NEJMoa2004444

De novo metastatic breast cancer represents 6% of all new breast cancer diagnoses. This figure has not changed at all over the past 20 years; however, systemic therapy options have evolved dramatically during this time and have significantly increased life expectancy for these patients. While surgical management of the primary tumor in the setting of metastatic disease has typically been reserved for palliative indications, surgeons are now being asked to consider resecting the primary tumor to potentially increase overall survival. In this episode, we will use a case study to examine the data that should inform our conversations and decisions when we encounter patients with metastatic breast cancer who are interested in having their primary tumor resected. Links: §  Khan, S.A., S. Schuetz, and O. Hosseini (2022). Primary-Site Local Therapy for Patients with De Novo Metastatic Breast Cancer: An Educational Review. Ann Surg Oncol; 29: 5811-5820. https://link.springer.com/article/10.1245/s10434-022-11900-x §  Khan, S.A. et al (2022). Early Local Therapy for the Primary Site in De Novo Stage IV Breast Cancer: Results of a Randomized Clinical Trial (E2108). J Clin Oncol; 40(9): 978-987. https://ascopubs.org/doi/10.1200/JCO.21.02006?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed §  Badwe, R. et al (2015). Locoregional treatment versus no treatment of the primary tumor in metastatic breast cancer: an open-label randomized controlled trial. Lancet Oncol; 16: 1380-1388. https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(15)00135-7/fulltext §  Fitzal, F. et al (2019). Impact of Breast Surgery in Primary Metastasized Breast Cancer: Outcomes of the Prospective Randomized Phase III ABCSG-28 POSYTIVE Trial. Ann Surg; 269(6): 1163-1169. https://journals.lww.com/annalsofsurgery/Abstract/2019/06000/Impact_of_Breast_Surgery_in_Primary_Metastasized.24.aspx §  Soran, A. et al (2018). Randomized Trial Comparing Resection of Primary Tumor with No Surgery in Stage IV Breast Cancer at Presentation: Protocol MF07-01. Ann Surg Oncol; 25: 3141-3149. https://link.springer.com/article/10.1245/s10434-018-6494-6 Please visit https://behindtheknife.org to access other high-yield surgical education podcasts, videos and more.   If you liked this episode, check out our other clinical challenges episodes here: https://behindtheknife.org/podcast-series/clinical-challenges/

In this episode of The Captains Lifestyle, Taylor is interviewing Mark England from the Enlifted Crew. It starts with a fun discussion about sex tonics and sex pills and later on gets into how our language shapes our reality. We are talking about the victim mentality, the stories we are telling ourselves and how to use our inner dialogue to our advantage and boost our performance. Gift Guide:https://the-captain-s-lifestyle.mykajabi.com/opt-in-b6dc9527-e4a4-4aec-b328-3435a75aa55b?preview_theme_id=2152261252 Captains Code:https://www.thecaptainslifestyle.com/opt-in Join the waitlist: https://www.thecaptainslifestyle.com/waitlistSponsorsLambs EMF Blocking Clothing (CODE: CAPTAINMORGAN): https://getlambs.com/?rfsn=5975040.ed1505HVMN Ketone-IQ™ (CODE: CAPTAINMORGAN20): https://hvmn.com/?rfsn=6210625.514868&utm_source=Refersion&utm_medium=influencer&utm_campaign=+TaylorMorgan How to find out more about Mark and the Enlifted method: https://enlifted.me/ Timestamps[00:00:00:00] Introduction and Sponsors[00:05:49:04] The story behind the magic sex concoction tonic[00:10:56:15] Whats up with the gas station Dig Pills [00:33:28:02] Breathe and Social Anxiety[00:34:42:03] What is the reticular activating system [00:40:13:21] Identity vs. Process: Reinterpreting Failure[00:56:30:08] What is it you created here[00:56:30:08] Let's play what is the good stuff [01:08:05:17] Most affirmations suck [01:18:35:14] The problem with going hard [01:33:25:06] How to build a great community [01:39:54:07] What if you keep going Mentionings: The invisible Gorilla https://www.youtube.com/watch?v=UtKt8YF7dgQ&t=220s Mark England Tedx Talk https://www.youtube.com/watch?v=K-6as-5dxSs NLP Richard Bandler https://www.richardbandler.com/ Hellinger School https://www.hellinger.com/en/family-constellation/ Conscious Language https://amzn.to/3ukkkAN Holographic Kinetics https://www.holographickinetics.com/ The Work Byron Katie https://thework.com/ Emotional Freedom technique https://www.emofree.com/ Rebirthing Leonard orr https://www.rebirthingbreathwork.com/ Mind power https://www.learnmindpower.com/ Robert Green 48 laws of power https://amzn.to/3VqxdVL Studies: - Tribulus Terrestis on testosterone https://journals.sagepub.com/doi/10.1177/0391560318802160?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed - Maca on sexdrive https://pubmed.ncbi.nlm.nih.gov/12472620/ - Zinc and Testosterone https://www.sciencedirect.com/science/article/abs/pii/S089990079680058X?via%3Dihub

EBB 244: Evidence on Artificial Rupture of Membranes, Assisted Vaginal Delivery, and Internal Monitoring.   We are so excited to announce the upcoming release of a new Evidence Based Birth(R) Pocket Guide, all about Interventions! To give you a sneak peek to the Invention Pocket Guide,  we are diving into the research and evidence on artificial rupture of membranes, assisted vaginal delivery an internal monitoring.   Content note: Discussion of the benefits and risks of these interventions, including forceps and vacuum-assisted deliveries, which can be associated with birthing trauma for birthing people and babies, as well as the risk of mortality. Resources: Make sure you're on the Pocket Guide wait list by going here  Amniotomy References: Kawakita, T., Huang, C-C, and Landy, H. J. (2018). Risk Factors for Umbilical Cord Prolapse at the Time of Artificial Rupture of Membranes. AJP Rep 8(2): e89-e94. https://pubmed.ncbi.nlm.nih.gov/29755833/ Simpson, K. R. (2020). Cervical Ripening and Labor Induction and Augmentation, 5th Edition. AWHONN Practice Monograph 24(4): PS1-S41. https://bmcpregnancychildbirth.biomedcentral.com/articles/10.1186/s12884-019-2491-4 Smyth, R. M., Markham, C. & Dowswell, T. (2013). Amniotomy for shortening spontaneous labour. Cochrane Database Syst Rev 6:CD006167. https://pubmed.ncbi.nlm.nih.gov/23780653/ Alfirevic, Z., Keeney, E., Dowswell, T., et al. (2016). Methods to induce labour: a systematic review, network meta-analysis and cost-effectiveness analysis. BJOG 123(9):  1462-1470. https://pubmed.ncbi.nlm.nih.gov/27001034/  de Vaan, M. D. T., ten Eikelder, M. L. G., Jozwiak, M., et al. (2019). Mechanical methods for induction of labour. Cochrane Database of Systematic Reviews 10: CD001233. https://www.cochrane.org/CD001233/PREG_mechanical-methods-induction-labour Simpson, K. R. (2020). Cervical Ripening and Labor Induction and Augmentation, 5th Edition. AWHONN Practice Monograph, 24(4), PS1-S41. https://nwhjournal.org/article/S1751-4851(20)30079-9/abstract   Assisted Vaginal Delivery References: NHS article on forceps or vacuum delivery https://www.nhs.uk/pregnancy/labour-and-birth/what-happens/forceps-or-vacuum-delivery/ Bailey, P. E., van Roosmalen, J., Mola, G., et al. (2017). Assisted vaginal delivery in low and middle income countries: an overview. BJOG 124(9): 1335-1344. https://pubmed.ncbi.nlm.nih.gov/28139878/ CDC Wonder Database Feeley, C., Crossland, N., Betran, A. P., et al. (2021). Training and expertise in undertaking assisted vaginal delivery (AVD): a mixed methods systematic review of practitioners views and experiences. Reprod Health 18(1): 92. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8097768/ Crossland, N., Kingdon, C., Balaam, M. C. (2020). Women's, partners' and health care providers' views and experiences of assisted vaginal birth: a systematic mixed methods review. Reprod Health 17:83. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268509/ Hook, C. D., Damos, J. R. (2008). Vacuum-Assisted Vaginal Delivery. Am Fam Physician 78(8): 953-960. https://www.aafp.org/afp/2008/1015/p953.html Tsakiridis, I., Giouleka, S., Mamopoulos, A., et al. (2020). Operative vaginal delivery: a review of four national guidelines. J Perinat Med 48(3): 189-198. https://pubmed.ncbi.nlm.nih.gov/31926101/ Verma, G. L., Spalding, J. J., Wilkinson, M. D., et al. (2021). Instruments for assisted vaginal birth. Cochrane Database Syst Rev. https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD005455.pub3/full   Internal Monitoring References: Euliano, T. Y., Darmanjian, S., Nguyen, M. T., et al. (2017). Monitoring fetal heart rate during labor: A comparison of three methods. J Pregnancy 2017: 8529816. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368359/ Neilson, J. P. (2015). Fetal electrocardiogram (ECG) for fetal monitoring during labor. Cochrane Database Syst Rev 12: CD000116. https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD000116.pub5/full Harper, L. M., Shanks, A. L., Tuuli, M. G., et al. (2013). The risks and benefits of internal monitors in laboring patients. Am J Obstet Gynecol 209(1): 38.e1-38.e6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760973/ Bakker, J. J. H., Verhoeven, C. J. M., Janssen, P. F., et al. (2010). Outcomes after internal versus external tocodynamometry for monitoring labor. N Engl J Med 362(4): 306-13. https://www.nejm.org/doi/10.1056/NEJMoa0902748?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200www.ncbi.nlm.nih.gov Frolova, A. I., Stout, M. J., Carter, E. B., et al. (2021). Internal fetal and uterine monitoring in obese patients and maternal obstetrical outcomes. Am J Obstet Gynecol MFM 3(1): 100282. https://pubmed.ncbi.nlm.nih.gov/33451595/ Bakker, J. J. H., Janssen, P. F., van Halem, K. (2013). Internal versus external tocodynamometry during induced or augmented labor. Cochrane Database Syst Rev 8: CD006947. https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD006947.pub3/full van Halem, K., Bakker, J. J. H., VerHoeven, C. J., et al. (2011). Does use of an intrauterine catheter during labor increase risk of infection? J Maternal Fetal Neonatal Med 25(4): 415-418. https://www.tandfonline.com/doi/abs/10.3109/14767058.2011.582905 For more information and news about Evidence Based Birth®, visit www.ebbirth.com. Find us on:  TikTok Instagram  Pinterest   Ready to get involved?  Check out our Professional membership (including scholarship options) here  Find an EBB Instructor here  Click here to learn more about the Evidence Based Birth® Childbirth Class.

References for chapter 8Robert Schrier proposed a unifying hypothesis to explain the sodium retention seen in edematous states like cirrhosis and heart failure, coining the term effective arterial blood volume (EABV). An open access review in JASN 2007 can be found here: https://jasn.asnjournals.org/content/18/7/2028#ref-3 John P PetersASN Annual Award: https://www.asn-online.org/about/awards/award.aspx?awh_key=0ea83199-f86d-4506-9507-d7e4ce688cb4Short article discussing contributions of Dr. Peters by mentees Dr. Franklin Epstein and Dr. Donald Seldin: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2588700/ and https://pubmed.ncbi.nlm.nih.gov/12097739/Epstein FH et al. Studies of the antidiuresis of quiet standing: the importance of changes in plasma volume and glomerular filtration. JCI 1950. In this classic report, investigators studied their own sodium excretion supine, standing and with a variety of maneuvers (saline or albumin infusion) and showed that urinary sodium excretion is limited in the upright position compared to supine position. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC436228/pdf/jcinvest00414-0077.pdfAn interesting review of early concepts on hypertension feature notes on John J Hay and Paul Dudley White. The former was known to say, “The greatest danger to a man with high blood pressure lies in its discovery because then some fool is certain to try and reduce it!” and the latter has been quoted as saying that hypertension might be compensatory but apparently, these quotes are out of context. To find out what they really said, check out: Elias MF and Goodell AL. Setting the record straight for two heroes in hypertension John J Hay and Paul Dudley White. J Clin Hypertens 2019 https://onlinelibrary.wiley.com/doi/epdf/10.1111/jch.13650 VA Cooperative Trial was an important study to establish the hypertension should, in fact, be treated The VA Cooperative Study and the Beginning of Routine Hypertension Screening, 1964-1980 This study was stopped after only 18 months because of an excess of deaths in the untreated group who had a mean diastolic BP of 115 mmHg. For a long time, only the diastolic BP was felt to be important until the Systolic Hypertension in Elderly Patients (“SHEP study”) clarified that treatment of isolated systolic hypertension is also importantPrevention of Stroke by Antihypertensive Drug Treatment in Older Persons With Isolated Systolic HypertensionWe continued to try to grapple with the work of Jens Titze on sodium which turns many of our assumptions about sodium upside down. His team studied astronauts on a long term high sodium diet and found an unexpected weekly (circaseptan) rhythm seemingly related inversely to aldosterone and directly with cortisol. His work also probes our notion of body sodium content. For a great first hand read, check out Dr TItze's review in Kidney International 2014 which he aptly dubs, “Spooky Sodium Balence.” https://www.sciencedirect.com/science/article/pii/S0085253815562807Epstein M. The cardiovascular and renal effects of head-out of water Immersion in Man. Circulation Research 1976 Cardiovascular and renal effects of head-out water immersion in man: application of the model in the assessment of volume homeosSpace flight is an exaggeration of the water immersion experiments. Astronauts on either a low or normal sodium diet had a reset of natriuetic peptides. A Salty Tale: Study Examines Sodium Regulation in Space and Natriuretic Peptide Resetting in Astronauts | CirculationBaroreceptors feature mechanically activated ion channels called PIEZO1 and PIEZO2. Zeng W, Marshall KL, Min S, Daou I, Chapleau MW, Abboud FM. PIEZOs mediate neuronal sensing of blood pressure and the baroreceptor reflex. Science 2018 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102061/We also relearned an unfortunate truth: lots of folks pee in pools. De Laat et al. Water Res. 2011. Concentration levels of urea in swimming pool water and reactivity of chlorine with urea At the American College of Cardiology meeting in April, investigators shared the news that the combination of an ARB with new class of drugs called angiotensin receptor neprilysin inhibitor (ARNI) was not superior to ACE inhibitors at reduction of heart failure following acute MI. Here's the press release for the PARADISE-MI trial. Prospective ARNI vs. ACE inhibitor trial to DetermIne Superiority in reducing heart failure Events after Myocardial InfarctionA series of elegant experiments by Alicia McDonald's team to characterize pressure natriuresis. In these studies, they induce hypertension by constriction of the superior mesenteric artery, the celiac artery and the infrarenal aorta (essentially increasing afterload without directly altering the blood flow to the kidney). With this maneuver, the blood pressure of the experimental animal rises, urinary sodium excretion increases and then they demonstrate a shift in the Na-H ATPase from the apical membrane to intracellular vesicles in the proximal tubule and a shift in NCC from the luminal membrane to the intracellular vesicles in the distal tubules. Yang L et. al Acute hypertension provokes internalization of proximal tubule NHE3 without inhibition of transport activity. Am J Physiol Renal 2002 https://journals.physiology.org/doi/full/10.1152/ajprenal.00298.2001?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.orgLee DH Riquier ADM, Yang LE, Leong PK, Maunsbach and McDonough AA. Acute hypertension provokes acute trafficking of distal tubule NaCl (NCC) to subapical cytoplasmic vesicles. Am J Physiol Renal Physiol. 2009 Acute hypertension provokes acute trafficking of distal tubule Na-Cl cotransporter (NCC) to subapical cytoplasmic vesicles This review in KI reports is also worth a read McDonough AA. Maintaining Balance under pressure-hypertension and the proximal tubule. 2015 ISN Forefronts Symposium 2015: Maintaining Balance Under Pressure—Hypertension and the Proximal Tubule

Drs. Tamara Fountain, Nathan Scott, and Basil Williams join for a discussion of a recent New England Journal of Medicine article outlining trends in racial representation in U.S. allopathic residency programs over the past decade. The article can be found at https://www.nejm.org/doi/10.1056/NEJMc2200107?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed.Relevant Financial Disclosures: None relevantYou can now claim CME credits via the AAO website. Visit https://www.aao.org/browse-multimedia?filter=Audi

Do bisexual men exist? Noted bisexual, "Are They Gay" joins us this week as we cover the studies that claimed to prove that bisexual men were, in fact, a myth. AreTheyGay's channel: https://www.youtube.com/c/AreTheyGay Grab our merch now: http://normalcitizen.store You can WATCH the podcast over on our YouTube channel: http://youtube.com/SciGuys Help keep the show running by supporting us on Patreon! http://patreon.com/sciguys If you'd like to see more of us, follow our socials! TikTok https://www.tiktok.com/@sciguys Twitter http://twitter.com/SciGuysPod Instagram http://instagram.com/SciGuysPod Facebook http://facebook.com/SciGuysPod Follow the SCI GUYS @notcorry / @jampkin / @lukecutforth References & Further Reading Arousal Pattern Studies & Articles https://www.nytimes.com/2005/07/05/health/straight-gay-or-lying-bisexuality-revisited.html https://journals.sagepub.com/doi/10.1111/j.1467-9280.2005.01578.x?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed& https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7749350/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8000017/ https://link.springer.com/article/10.1007/s10508-011-9881-7 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7749278/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175819/ https://link.springer.com/article/10.1007/s10508-011-9746-0 https://www.pnas.org/doi/10.1073/pnas.2003631117 https://bi.org/en/questions/all-women-are-bisexual-but-bi-men-dont-exist-right eadt.co.uk/news/university-of-essex-research-on-bisexual-men-2685984 https://www.bbc.co.uk/news/health-34744903 Bisexuality & Kinsey Scale https://www.stonewall.org.uk/about-us/news/short-history-word-bisexuality https://bi.org/en/101/Kinsey-Klein https://kinseyinstitute.org/research/publications/kinsey-scale.php