Podcasts about z39

Third-year OHSU medical students, Candace Chan and Devon Boorstein-Holler rehash the information from our first sleep medicine & psychiatry talk in a question-and-answer format. This episode is part of a project to help determine optimal podcast formats for student learning. Hosted by: Devon Boorstein-Holler, MS3 & Candace Chan, MS3 Questions? psychiatryexplored@gmail.com Studies Mentioned: Overview on the pharmacology of sleep: https://aasm.org/resources/pdf/pharmacologictreatmentofinsomnia.pdf Study on melatonin in OTC: https://jcsm.aasm.org/doi/full/10.5664/jcsm.6434 NEJM Bob Sack review melatonin for jet lag: https://www.nejm.org/doi/10.1056/NEJMcp0909838?url_ver=Z39.88-%202003&rft_id=ori:rid:crossref.org&rfr_dat-cr_pub%20%200pubmed Study on two groups with insomnia or not, odds to develop depression: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108260/ Resource for online CBTI: https://www.sleepfoundation.org/insomnia/treatment/cognitive-behavioral-therapy-insomnia CBTI for depression: https://academic.oup.com/sleep/article/31/4/489/2454177?login=true IRT vs. IRT+CBT vs. Prazosin: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4265653/

De novo metastatic breast cancer represents 6% of all new breast cancer diagnoses. This figure has not changed at all over the past 20 years; however, systemic therapy options have evolved dramatically during this time and have significantly increased life expectancy for these patients. While surgical management of the primary tumor in the setting of metastatic disease has typically been reserved for palliative indications, surgeons are now being asked to consider resecting the primary tumor to potentially increase overall survival. In this episode, we will use a case study to examine the data that should inform our conversations and decisions when we encounter patients with metastatic breast cancer who are interested in having their primary tumor resected. Links: §  Khan, S.A., S. Schuetz, and O. Hosseini (2022). Primary-Site Local Therapy for Patients with De Novo Metastatic Breast Cancer: An Educational Review. Ann Surg Oncol; 29: 5811-5820. https://link.springer.com/article/10.1245/s10434-022-11900-x §  Khan, S.A. et al (2022). Early Local Therapy for the Primary Site in De Novo Stage IV Breast Cancer: Results of a Randomized Clinical Trial (E2108). J Clin Oncol; 40(9): 978-987. https://ascopubs.org/doi/10.1200/JCO.21.02006?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed §  Badwe, R. et al (2015). Locoregional treatment versus no treatment of the primary tumor in metastatic breast cancer: an open-label randomized controlled trial. Lancet Oncol; 16: 1380-1388. https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(15)00135-7/fulltext §  Fitzal, F. et al (2019). Impact of Breast Surgery in Primary Metastasized Breast Cancer: Outcomes of the Prospective Randomized Phase III ABCSG-28 POSYTIVE Trial. Ann Surg; 269(6): 1163-1169. https://journals.lww.com/annalsofsurgery/Abstract/2019/06000/Impact_of_Breast_Surgery_in_Primary_Metastasized.24.aspx §  Soran, A. et al (2018). Randomized Trial Comparing Resection of Primary Tumor with No Surgery in Stage IV Breast Cancer at Presentation: Protocol MF07-01. Ann Surg Oncol; 25: 3141-3149. https://link.springer.com/article/10.1245/s10434-018-6494-6 Please visit https://behindtheknife.org to access other high-yield surgical education podcasts, videos and more.   If you liked this episode, check out our other clinical challenges episodes here: https://behindtheknife.org/podcast-series/clinical-challenges/

In this episode of The Captains Lifestyle, Taylor is interviewing Mark England from the Enlifted Crew. It starts with a fun discussion about sex tonics and sex pills and later on gets into how our language shapes our reality. We are talking about the victim mentality, the stories we are telling ourselves and how to use our inner dialogue to our advantage and boost our performance. Gift Guide:https://the-captain-s-lifestyle.mykajabi.com/opt-in-b6dc9527-e4a4-4aec-b328-3435a75aa55b?preview_theme_id=2152261252 Captains Code:https://www.thecaptainslifestyle.com/opt-in Join the waitlist: https://www.thecaptainslifestyle.com/waitlistSponsorsLambs EMF Blocking Clothing (CODE: CAPTAINMORGAN): https://getlambs.com/?rfsn=5975040.ed1505HVMN Ketone-IQ™ (CODE: CAPTAINMORGAN20): https://hvmn.com/?rfsn=6210625.514868&utm_source=Refersion&utm_medium=influencer&utm_campaign=+TaylorMorgan How to find out more about Mark and the Enlifted method: https://enlifted.me/ Timestamps[00:00:00:00] Introduction and Sponsors[00:05:49:04] The story behind the magic sex concoction tonic[00:10:56:15] Whats up with the gas station Dig Pills [00:33:28:02] Breathe and Social Anxiety[00:34:42:03] What is the reticular activating system [00:40:13:21] Identity vs. Process: Reinterpreting Failure[00:56:30:08] What is it you created here[00:56:30:08] Let's play what is the good stuff [01:08:05:17] Most affirmations suck [01:18:35:14] The problem with going hard [01:33:25:06] How to build a great community [01:39:54:07] What if you keep going Mentionings: The invisible Gorilla https://www.youtube.com/watch?v=UtKt8YF7dgQ&t=220s Mark England Tedx Talk https://www.youtube.com/watch?v=K-6as-5dxSs NLP Richard Bandler https://www.richardbandler.com/ Hellinger School https://www.hellinger.com/en/family-constellation/ Conscious Language https://amzn.to/3ukkkAN Holographic Kinetics https://www.holographickinetics.com/ The Work Byron Katie https://thework.com/ Emotional Freedom technique https://www.emofree.com/ Rebirthing Leonard orr https://www.rebirthingbreathwork.com/ Mind power https://www.learnmindpower.com/ Robert Green 48 laws of power https://amzn.to/3VqxdVL Studies: - Tribulus Terrestis on testosterone https://journals.sagepub.com/doi/10.1177/0391560318802160?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed - Maca on sexdrive https://pubmed.ncbi.nlm.nih.gov/12472620/ - Zinc and Testosterone https://www.sciencedirect.com/science/article/abs/pii/S089990079680058X?via%3Dihub

EBB 244: Evidence on Artificial Rupture of Membranes, Assisted Vaginal Delivery, and Internal Monitoring.   We are so excited to announce the upcoming release of a new Evidence Based Birth(R) Pocket Guide, all about Interventions! To give you a sneak peek to the Invention Pocket Guide,  we are diving into the research and evidence on artificial rupture of membranes, assisted vaginal delivery an internal monitoring.   Content note: Discussion of the benefits and risks of these interventions, including forceps and vacuum-assisted deliveries, which can be associated with birthing trauma for birthing people and babies, as well as the risk of mortality. Resources: Make sure you're on the Pocket Guide wait list by going here  Amniotomy References: Kawakita, T., Huang, C-C, and Landy, H. J. (2018). Risk Factors for Umbilical Cord Prolapse at the Time of Artificial Rupture of Membranes. AJP Rep 8(2): e89-e94. https://pubmed.ncbi.nlm.nih.gov/29755833/ Simpson, K. R. (2020). Cervical Ripening and Labor Induction and Augmentation, 5th Edition. AWHONN Practice Monograph 24(4): PS1-S41. https://bmcpregnancychildbirth.biomedcentral.com/articles/10.1186/s12884-019-2491-4 Smyth, R. M., Markham, C. & Dowswell, T. (2013). Amniotomy for shortening spontaneous labour. Cochrane Database Syst Rev 6:CD006167. https://pubmed.ncbi.nlm.nih.gov/23780653/ Alfirevic, Z., Keeney, E., Dowswell, T., et al. (2016). Methods to induce labour: a systematic review, network meta-analysis and cost-effectiveness analysis. BJOG 123(9):  1462-1470. https://pubmed.ncbi.nlm.nih.gov/27001034/  de Vaan, M. D. T., ten Eikelder, M. L. G., Jozwiak, M., et al. (2019). Mechanical methods for induction of labour. Cochrane Database of Systematic Reviews 10: CD001233. https://www.cochrane.org/CD001233/PREG_mechanical-methods-induction-labour Simpson, K. R. (2020). Cervical Ripening and Labor Induction and Augmentation, 5th Edition. AWHONN Practice Monograph, 24(4), PS1-S41. https://nwhjournal.org/article/S1751-4851(20)30079-9/abstract   Assisted Vaginal Delivery References: NHS article on forceps or vacuum delivery https://www.nhs.uk/pregnancy/labour-and-birth/what-happens/forceps-or-vacuum-delivery/ Bailey, P. E., van Roosmalen, J., Mola, G., et al. (2017). Assisted vaginal delivery in low and middle income countries: an overview. BJOG 124(9): 1335-1344. https://pubmed.ncbi.nlm.nih.gov/28139878/ CDC Wonder Database Feeley, C., Crossland, N., Betran, A. P., et al. (2021). Training and expertise in undertaking assisted vaginal delivery (AVD): a mixed methods systematic review of practitioners views and experiences. Reprod Health 18(1): 92. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8097768/ Crossland, N., Kingdon, C., Balaam, M. C. (2020). Women's, partners' and health care providers' views and experiences of assisted vaginal birth: a systematic mixed methods review. Reprod Health 17:83. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268509/ Hook, C. D., Damos, J. R. (2008). Vacuum-Assisted Vaginal Delivery. Am Fam Physician 78(8): 953-960. https://www.aafp.org/afp/2008/1015/p953.html Tsakiridis, I., Giouleka, S., Mamopoulos, A., et al. (2020). Operative vaginal delivery: a review of four national guidelines. J Perinat Med 48(3): 189-198. https://pubmed.ncbi.nlm.nih.gov/31926101/ Verma, G. L., Spalding, J. J., Wilkinson, M. D., et al. (2021). Instruments for assisted vaginal birth. Cochrane Database Syst Rev. https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD005455.pub3/full   Internal Monitoring References: Euliano, T. Y., Darmanjian, S., Nguyen, M. T., et al. (2017). Monitoring fetal heart rate during labor: A comparison of three methods. J Pregnancy 2017: 8529816. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368359/ Neilson, J. P. (2015). Fetal electrocardiogram (ECG) for fetal monitoring during labor. Cochrane Database Syst Rev 12: CD000116. https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD000116.pub5/full Harper, L. M., Shanks, A. L., Tuuli, M. G., et al. (2013). The risks and benefits of internal monitors in laboring patients. Am J Obstet Gynecol 209(1): 38.e1-38.e6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760973/ Bakker, J. J. H., Verhoeven, C. J. M., Janssen, P. F., et al. (2010). Outcomes after internal versus external tocodynamometry for monitoring labor. N Engl J Med 362(4): 306-13. https://www.nejm.org/doi/10.1056/NEJMoa0902748?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200www.ncbi.nlm.nih.gov Frolova, A. I., Stout, M. J., Carter, E. B., et al. (2021). Internal fetal and uterine monitoring in obese patients and maternal obstetrical outcomes. Am J Obstet Gynecol MFM 3(1): 100282. https://pubmed.ncbi.nlm.nih.gov/33451595/ Bakker, J. J. H., Janssen, P. F., van Halem, K. (2013). Internal versus external tocodynamometry during induced or augmented labor. Cochrane Database Syst Rev 8: CD006947. https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD006947.pub3/full van Halem, K., Bakker, J. J. H., VerHoeven, C. J., et al. (2011). Does use of an intrauterine catheter during labor increase risk of infection? J Maternal Fetal Neonatal Med 25(4): 415-418. https://www.tandfonline.com/doi/abs/10.3109/14767058.2011.582905 For more information and news about Evidence Based Birth®, visit www.ebbirth.com. Find us on:  TikTok Instagram  Pinterest   Ready to get involved?  Check out our Professional membership (including scholarship options) here  Find an EBB Instructor here  Click here to learn more about the Evidence Based Birth® Childbirth Class.

The idea of applying machine learning and digital pathology platforms to everyday workflows in the clinical microbiology laboratory has become increasing intriguing and appealing, especially as labs continue to optimize efficiency in the midst of workforce shortages. The promise of this new digital frontier is multifold, including decreasing turnaround time and potentially cost, and freeing up technologist time to focus on higher yield activities in the lab. Many labs have now taken the initial leap into automated culture and imaging systems, but what's next? Are the digital pathology AI algorithms ready for prime-time in clinical microbiology labs? Is the future now? Guests: Dr. Niaz Banaei, Medical Director of the Stanford Health Care Clinical Microbiology Laboratory and Professor of Pathology and Medicine at Stanford University Dr. Dan Rhoads, Section Head of Microbiology at Cleveland Clinic This episode of Editors in Conversation is brought to you by the Journal of Clinical Microbiology and hosted by JCM Editor in Chief, Alex McAdam and Dr. Elli Theel. JCM is available at https://jcm.asm.org and on https://twitter.com/JClinMicro. Links/Refences: Evaluation of MetaSystems automated fluorescent microscopy system for the machine-assisted detection of acid-fast bacilli in clinical samples. https://journals.asm.org/doi/10.1128/jcm.01131-22 Computer vision and artifical intelligence are emerging diagnostic tools for the clinical microbiologist. https://journals.asm.org/doi/10.1128/JCM.00511-20?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed Visit journals.asm.org/journal/jcm to read articles and/or submit a manuscript. Follow JCM on Twitter via @JClinMicro

[CE contact hours--see below.] Improving quality of life for patients with heart failure can include lifestyle modifications and require successful behavior change strategies. Learn best practices to apply into your clinical setting from nurse providers Colleen McIlvennan, PhD, DNP, ANP, FAHA, FHFSA, of the University of Colorado in Denver, and Binu Koirala, PhD, MGS, RN, of the Johns Hopkins University School of Nursing in Baltimore.CE LINK: https://pcna.net/?p=10717&post_type=online-course&preview_id=10717PCNA Behavior Change mini-certifice (CE course): https://pcna.net/professional-development/online-learning/ "Behavior Change mini-certificate"AHA HF Tools & Resources: heart.org/en/health-topics/heart-failure/heart-failure-tools-resourcesAdherence to Healthy Sleep Patterns: ahajournals.org/doi/10.1161/CIRCULATIONAHA.120.050792?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed&Addressing Social Determinants of Health in Patients with HF: ahajournals.org/doi/10.1161/CIR.0000000000000767See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

References for chapter 8Robert Schrier proposed a unifying hypothesis to explain the sodium retention seen in edematous states like cirrhosis and heart failure, coining the term effective arterial blood volume (EABV). An open access review in JASN 2007 can be found here: https://jasn.asnjournals.org/content/18/7/2028#ref-3 John P PetersASN Annual Award: https://www.asn-online.org/about/awards/award.aspx?awh_key=0ea83199-f86d-4506-9507-d7e4ce688cb4Short article discussing contributions of Dr. Peters by mentees Dr. Franklin Epstein and Dr. Donald Seldin: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2588700/ and https://pubmed.ncbi.nlm.nih.gov/12097739/Epstein FH et al. Studies of the antidiuresis of quiet standing: the importance of changes in plasma volume and glomerular filtration. JCI 1950. In this classic report, investigators studied their own sodium excretion supine, standing and with a variety of maneuvers (saline or albumin infusion) and showed that urinary sodium excretion is limited in the upright position compared to supine position. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC436228/pdf/jcinvest00414-0077.pdfAn interesting review of early concepts on hypertension feature notes on John J Hay and Paul Dudley White. The former was known to say, “The greatest danger to a man with high blood pressure lies in its discovery because then some fool is certain to try and reduce it!” and the latter has been quoted as saying that hypertension might be compensatory but apparently, these quotes are out of context. To find out what they really said, check out: Elias MF and Goodell AL. Setting the record straight for two heroes in hypertension John J Hay and Paul Dudley White. J Clin Hypertens 2019 https://onlinelibrary.wiley.com/doi/epdf/10.1111/jch.13650 VA Cooperative Trial was an important study to establish the hypertension should, in fact, be treated The VA Cooperative Study and the Beginning of Routine Hypertension Screening, 1964-1980 This study was stopped after only 18 months because of an excess of deaths in the untreated group who had a mean diastolic BP of 115 mmHg. For a long time, only the diastolic BP was felt to be important until the Systolic Hypertension in Elderly Patients (“SHEP study”) clarified that treatment of isolated systolic hypertension is also importantPrevention of Stroke by Antihypertensive Drug Treatment in Older Persons With Isolated Systolic HypertensionWe continued to try to grapple with the work of Jens Titze on sodium which turns many of our assumptions about sodium upside down. His team studied astronauts on a long term high sodium diet and found an unexpected weekly (circaseptan) rhythm seemingly related inversely to aldosterone and directly with cortisol. His work also probes our notion of body sodium content. For a great first hand read, check out Dr TItze's review in Kidney International 2014 which he aptly dubs, “Spooky Sodium Balence.” https://www.sciencedirect.com/science/article/pii/S0085253815562807Epstein M. The cardiovascular and renal effects of head-out of water Immersion in Man. Circulation Research 1976 Cardiovascular and renal effects of head-out water immersion in man: application of the model in the assessment of volume homeosSpace flight is an exaggeration of the water immersion experiments. Astronauts on either a low or normal sodium diet had a reset of natriuetic peptides. A Salty Tale: Study Examines Sodium Regulation in Space and Natriuretic Peptide Resetting in Astronauts | CirculationBaroreceptors feature mechanically activated ion channels called PIEZO1 and PIEZO2. Zeng W, Marshall KL, Min S, Daou I, Chapleau MW, Abboud FM. PIEZOs mediate neuronal sensing of blood pressure and the baroreceptor reflex. Science 2018 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102061/We also relearned an unfortunate truth: lots of folks pee in pools. De Laat et al. Water Res. 2011. Concentration levels of urea in swimming pool water and reactivity of chlorine with urea At the American College of Cardiology meeting in April, investigators shared the news that the combination of an ARB with new class of drugs called angiotensin receptor neprilysin inhibitor (ARNI) was not superior to ACE inhibitors at reduction of heart failure following acute MI. Here's the press release for the PARADISE-MI trial. Prospective ARNI vs. ACE inhibitor trial to DetermIne Superiority in reducing heart failure Events after Myocardial InfarctionA series of elegant experiments by Alicia McDonald's team to characterize pressure natriuresis. In these studies, they induce hypertension by constriction of the superior mesenteric artery, the celiac artery and the infrarenal aorta (essentially increasing afterload without directly altering the blood flow to the kidney). With this maneuver, the blood pressure of the experimental animal rises, urinary sodium excretion increases and then they demonstrate a shift in the Na-H ATPase from the apical membrane to intracellular vesicles in the proximal tubule and a shift in NCC from the luminal membrane to the intracellular vesicles in the distal tubules. Yang L et. al Acute hypertension provokes internalization of proximal tubule NHE3 without inhibition of transport activity. Am J Physiol Renal 2002 https://journals.physiology.org/doi/full/10.1152/ajprenal.00298.2001?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.orgLee DH Riquier ADM, Yang LE, Leong PK, Maunsbach and McDonough AA. Acute hypertension provokes acute trafficking of distal tubule NaCl (NCC) to subapical cytoplasmic vesicles. Am J Physiol Renal Physiol. 2009 Acute hypertension provokes acute trafficking of distal tubule Na-Cl cotransporter (NCC) to subapical cytoplasmic vesicles This review in KI reports is also worth a read McDonough AA. Maintaining Balance under pressure-hypertension and the proximal tubule. 2015 ISN Forefronts Symposium 2015: Maintaining Balance Under Pressure—Hypertension and the Proximal Tubule

Drs. Tamara Fountain, Nathan Scott, and Basil Williams join for a discussion of a recent New England Journal of Medicine article outlining trends in racial representation in U.S. allopathic residency programs over the past decade. The article can be found at https://www.nejm.org/doi/10.1056/NEJMc2200107?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed.Relevant Financial Disclosures: None relevantYou can now claim CME credits via the AAO website. Visit https://www.aao.org/browse-multimedia?filter=Audi

In this podcast, we interview Professor Joel Palefsky about the ANCHOR study. Sexually Transmitted Infections' Editorial Fellow, Dr Ming Lee, speaks to the journal Editor in Chief, Professor Anna Maria Geretti, and Professor Palefsky, chief investigator of the randomised controlled trial, about the study which investigated treatment of anal high-grade squamous intraepithelial lesions (HSIL) to prevent progression to anal cancer. The study was stopped early following an interim analysis showing a clear benefit in reducing the risk of progression to anal cancer by 57 %, and the findings were recently published in the New England Journal of Medicine. Professor Palefsky also discusses how screening for anal cancer could be improved. Related link about the ANCHOR study: https://www.nejm.org/doi/10.1056/NEJMoa2201048?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed

The discussion over what aspect of our diet has been driving the escalation of metabolic disease over the last 100 years has been a confusing one full of contradictory information. It would be logical to look for a change in our diet associated with such a dramatic change in the health of a population There are both correlated evidence and dietary trials to support the theory that the increase in linoleic acid, provided by the introduction of PUFA processed oils into our diet, is the driver. In this episode of Hunger Hunt Feast, I want to share a collection of them to help clarify some of the confusion. -- Episode Specific Links:  Linoleic acid concentrations in fats and oils http://www.distributionkatrina.com/english/comparison-of-dietary-fats.html Increase in Adipose Tissue Linoleic Acid of US Adults in the Last Half-Century https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC4642429/ Composition of adipose tissue and marrow fat in humans by 1H NMR at 7 Tesla https://www.sciencedirect.com/science/article/pii/S0022227520346733 Diets could prevent many diseases https://www.researchgate.net/publication/10673140_Diets_could_prevent_many_diseases Corn Oil in Treatment of Ischemic Heart Disease https://ncbi.nlm.nih.gov/pmc/articles/PMC2166702/ Linoleic acid causes greater weight gain than saturated fat without hypothalamic inflammation in the male mouse https://pubmed.ncbi.nlm.nih.gov/27886622/#:~:text=the%20male%20mouse-,Linoleic%20acid%20causes%20greater%20weight%20gain%20than%20saturated%20fat%20without,doi%3A%2010.1016%2Fj Effects of fatty acids on mitochondria: implications for cell death https://pubmed.ncbi.nlm.nih.gov/12206909/ Can linoleic acid contribute to coronary artery disease? https://pubmed.ncbi.nlm.nih.gov/8192728/ Effects of linoleate-enriched and oleate-enriched diets in combination with alpha-tocopherol on the susceptibility of LDL and LDL subfractions to oxidative modification in humans https://pubmed.ncbi.nlm.nih.gov/8148354/ Acrolein is a product of lipid peroxidation reaction https://www.jbc.org/article/S0021-9258(18)80708-6/fulltext#seccestitle90 The role of dietary oxidized cholesterol and oxidized fatty acids in the development of atherosclerosis https://pubmed.ncbi.nlm.nih.gov/16270280/ Rapeseed oil and sunflower oil diets enhance platelet in vitro aggregation and thromboxane production in healthy men when compared with milk fat or habitual diets https://pubmed.ncbi.nlm.nih.gov/1641826/ Stearoyl-CoA Desaturase-1 Is Associated with Insulin Resistance in Morbidly Obese Subjects https://link.springer.com/article/10.2119/molmed.2010.00078 Circulating levels of linoleic acid and HDL-cholesterol are major determinants of 4-hydroxynonenal protein adducts in patients with heart failure https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909262/ Circulating levels of linoleic acid and HDL-cholesterol are major determinants of 4-hydroxynonenal protein adducts in patients with heart failure https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909262/ Role of Physiological Levels of 4-Hydroxynonenal on Adipocyte Biology: Implications for Obesity and Metabolic Syndrome https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038367/ “The Hateful Eight: Enemy Fats That Destroy Your Health - Dr. Cate.” Dr. Cate, 22 May 2020,  https://drcate.com/the-hateful-eight-enemy-fats-that-destroy-your-health/ Effects of diets enriched in linoleic acid and its peroxidation products on brain fatty acids, oxylipins, and aldehydes in mice https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC6180905/ Strong increase in hydroxy fatty acids derived from linoleic acid in human low-density lipoproteins of atherosclerotic patients https://pubmed.ncbi.nlm.nih.gov/9488997/ Brief episode of STZ-induced hyperglycemia produces cardiac abnormalities in rats fed a diet rich in n-6 PUFA https://journals.physiology.org/doi/full/10.1152/ajpheart.00480.2004?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org Changes in Dietary Fat Intake Alter Plasma Levels of Oxidized Low-Density Lipoprotein and Lipoprotein(a) https://pubmed.ncbi.nlm.nih.gov/9844997/ “Dr. Knobbe Presents, ‘Macular Degeneration - Preventable & Treatable - With an Ancestral Diet?' at Weston A. Price Foundation's Annual Conference - Wise Traditions - 2017 - Cure AMD Foundation.” Cure AMD Foundation, https://www.cureamd.org/dr-knobbe-presents-macular-degeneration-preventable-treatable-with-an-ancestral-diet-at-weston-a-price-foundations-annual-conference-wise-traditions-2017/ Unsaturated fatty acids and their oxidation products stimulate CD36 expression in human macrophages https://www.researchgate.net/publication/11260045_Unsaturated_fatty_acids_and_their_oxidation_products_stimulate_CD36_expression_in_human_macrophages Lowering dietary linoleic acid (LA) reduces bioactive oxidized linoleic acid metabolites in humans https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC3467319/ Can linoleic acid contribute to coronary artery disease? https://www.researchgate.net/publication/15005994_Can_linoleic_acid_contribute_to_coronary_artery_disease A high linoleic acid diet increases oxidative stress in vivo and affects nitric oxide metabolism in humans https://pubmed.ncbi.nlm.nih.gov/9844997/ Dietary Linoleic Acid Elevates Endogenous 2-AG and Anandamide and Induces Obesity https://onlinelibrary.wiley.com/doi/full/10.1038/oby.2012.38 Use of dietary linoleic acid for secondary prevention of coronary heart disease and death: evaluation of recovered data from the Sydney Diet Heart Study and updated meta-analysis https://www.bmj.com/content/346/bmj.e8707 Connect with Zane: ReLyte Electrolytes by Redmond Real Salt: https://shop.redmond.life?afmc=Zane Follow me on Instagram: https://www.instagram.com/zanegriggsfitness Follow me on YouTube: https://www.youtube.com/c/ZaneGriggs QUICK EPISODE SUMMARY What causes modern disease The hateful eight oils The correlation between vegetable oils and obesity The oxidation effects of LDL The truth about the dairy data How much cholesterol is in your brain  Where you can find a copy of today's mentioned study What we know about Linoleic acid

Sleep psychiatrist Dr. Emens and sleep specialist Dr. Mukundan take on the topic sleep medicine through a psychiatric lens. Hosted by Tom Bartlett and Nakai Corral Questions? psychiatryexplored@gmail.com Topics covered: Importance of sleep Cognitive behavioral therapy for insomnia Melatonin Substance use and ADHD Benzodiazepines and BZRAs PTSD Studies Mentioned: Overview on pharmacology of sleep: https://aasm.org/resources/pdf/pharmacologictreatmentofinsomnia.pdf Study on melatonin in OTC: https://jcsm.aasm.org/doi/full/10.5664/jcsm.6434 NEJM Bob Sack review melatonin for jet lag: https://www.nejm.org/doi/10.1056/NEJMcp0909838?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed Dr. Sack's study on blind individuals and melatonin: https://grantome.com/grant/NIH/R01-MH056874-01 Study on two groups with insomnia or not, odds to develop depression: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108260/ Resource for online CBTi: https://www.sleepfoundation.org/insomnia/treatment/cognitive-behavioral-therapy-insomnia CBTI for depression: https://academic.oup.com/sleep/article/31/4/489/2454177?login=true Cannabis and sleep: https://pubmed.ncbi.nlm.nih.gov/31895189/ IRT vs. IRT + CBT vs. Prazosin: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4265653/

Do bisexual men exist? Noted bisexual, "Are They Gay" joins us this week as we cover the studies that claimed to prove that bisexual men were, in fact, a myth. AreTheyGay's channel: https://www.youtube.com/c/AreTheyGay Grab our merch now: http://normalcitizen.store You can WATCH the podcast over on our YouTube channel: http://youtube.com/SciGuys Help keep the show running by supporting us on Patreon! http://patreon.com/sciguys If you'd like to see more of us, follow our socials! TikTok https://www.tiktok.com/@sciguys Twitter http://twitter.com/SciGuysPod Instagram http://instagram.com/SciGuysPod Facebook http://facebook.com/SciGuysPod Follow the SCI GUYS @notcorry / @jampkin / @lukecutforth References & Further Reading Arousal Pattern Studies & Articles https://www.nytimes.com/2005/07/05/health/straight-gay-or-lying-bisexuality-revisited.html https://journals.sagepub.com/doi/10.1111/j.1467-9280.2005.01578.x?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed& https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7749350/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8000017/ https://link.springer.com/article/10.1007/s10508-011-9881-7 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7749278/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175819/ https://link.springer.com/article/10.1007/s10508-011-9746-0 https://www.pnas.org/doi/10.1073/pnas.2003631117 https://bi.org/en/questions/all-women-are-bisexual-but-bi-men-dont-exist-right eadt.co.uk/news/university-of-essex-research-on-bisexual-men-2685984 https://www.bbc.co.uk/news/health-34744903 Bisexuality & Kinsey Scale https://www.stonewall.org.uk/about-us/news/short-history-word-bisexuality https://bi.org/en/101/Kinsey-Klein https://kinseyinstitute.org/research/publications/kinsey-scale.php

Phil and Matt discuss a new impactful mini review paper from Stephan Van der Zwaard and colleagues on what adaptations endurance athletes should be chasing in the muscle fiber proper.Papers discussed:https://www.frontiersin.org/articles/10.3389/fspor.2021.719434/full#B134https://journals.physiology.org/doi/prev/20210513-aop/abs/10.1152/japplphysiol.00056.2021https://journals.physiology.org/doi/full/10.1152/japplphysiol.00946.2017?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org Oxidative Potential Podcast LinksInstagram Links:https://www.instagram.com/criticalo2/?hl=enhttps://www.instagram.com/resiliencehpc/?hl=enYoutube Links:https://www.youtube.com/channel/UCfkBVklDMTPMbaPw0ikG2tgWebsite Links:https://www.resiliencehpc.ca/

Neste episódio vou apresentar um estudo multicêntrico realizado no Reino Unido, publicado no NEJM em agosto de 2017, onde pesquisadores buscaram avaliar as relações entre o uso da aspirina e a prevenção de pré-eclâmpsia. Também vou explicar o que significa a odds ratio, conceito que ainda causa confusão. Artigo disponível em: https://www.nejm.org/doi/10.1056/NEJMoa1704559?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200www.ncbi.nlm.nih.gov

Um vira-lata late para outro. Um buldogue late para um labrador. Um golden retriever late para um vira-lata.Afinal, eles se entendem? Raças diferentes de cachorros têm sotaques próprios?O que a ciência tem a dizer sobre isso?Confira o papo entre o leigo curioso, Ken Fujioka, e o cientista PhD, Altay de Souza.> OUÇA (47min 29s)*Naruhodo! é o podcast pra quem tem fome de aprender. Ciência, senso comum, curiosidades, desafios e muito mais. Com o leigo curioso, Ken Fujioka, e o cientista PhD, Altay de Souza.Edição: Reginaldo Cursino.http://naruhodo.b9.com.br*PARCERIA: ALURAA Alura tem mais de 1.000 cursos de diversas áreas e é a maior plataforma de cursos online do Brasil -- e você tem acesso a todos com uma única assinatura.Aproveite o desconto de R$100 para ouvintes Naruhodo no link:https://bit.ly/naruhodo_alura*REFERÊNCIASContinent-wide Shifts in Song Dialects of White-Throated Sparrowshttps://www.sciencedirect.com/science/article/pii/S0960982220307715Segregation of information in a complex acoustic signal: individual and dialect identity in white-crowned sparrow songhttps://www.sciencedirect.com/science/article/abs/pii/S0003347207002564Does true syntax or simple auditory object support the role of skylark song dialect?https://www.sciencedirect.com/science/article/abs/pii/S0003347213004235Disentangling canid howls across multiple species and subspecies: Structure in a complex communication channelhttps://www.sciencedirect.com/science/article/abs/pii/S0376635716300067#fig0030Vocal dialects and their implications for bird reintroductionshttps://www.sciencedirect.com/science/article/pii/S2530064417301384Acoustic differentiation of Shiho- and Naisa-type short-finned pilot whales in the Pacific Oceanhttps://asa.scitation.org/doi/10.1121/1.4974858Syntactic structure and geographical dialects in the songs of male rock hyraxeshttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3385477/Primate Communicationhttps://www.nature.com/scitable/knowledge/library/primate-communication-67560503/Dialects of an invasive songbird are preserved in its invaded but not native source rangehttps://onlinelibrary.wiley.com/doi/epdf/10.1111/ecog.02779Cultural transmission of vocal dialect in the naked mole-rathttps://www.science.org/doi/10.1126/science.abc6588?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmedThe naked truth: a comprehensive clarification and classification of current ‘myths' in naked mole-rat biologyhttps://onlinelibrary.wiley.com/doi/full/10.1111/brv.12791Why are no animal communication systems simple languages?https://www.frontiersin.org/articles/10.3389/fpsyg.2021.602635/fullNaruhodo #283 - Como se formam os sotaques e as gírias?https://www.youtube.com/watch?v=JmXjRynAZqo&ab_channel=Cient%C3%ADstica%26PodcastNaruhodoNaruhodo #212 - Cachorros podem se comunicar como humanos?https://www.youtube.com/watch?v=geb6PwSv1v8&ab_channel=Cient%C3%ADstica%26PodcastNaruhodoEspecial ENERGIA QUE TRANSFORMA - Ep. 1: O que é o Projeto Baleia Jubarte e por que ele é importante?https://www.b9.com.br/shows/naruhodo/naruhodo-extra-serie-especial-energia-que-transforma-episodio-1-o-que-e-o-projeto-baleia-jubarte-e-por-que-ele-e-importante/*APOIE O NARUHODO PELA PLATAFORMA ORELO!Um aviso importantíssimo: o podcast Naruhodo agora está no Orelo: https://bit.ly/naruhodo-no-oreloE é por meio dessa plataforma de apoio aos criadores de conteúdo que você ajuda o Naruhodo a se manter no ar.Você escolhe um valor de contribuição mensal e tem acesso a conteúdos exclusivos, conteúdos antecipados e vantagens especiais.Além disso, você pode ter acesso ao nosso grupo fechado no Telegram, e conversar comigo, com o Altay e com outros apoiadores.E não é só isso: toda vez que você ouvir ou fizer download de um episódio pelo Orelo, vai também estar pingando uns trocadinhos para o nosso projeto.Então, baixe agora mesmo o app Orelo no endereço Orelo.CC ou na sua loja de aplicativos e ajude a fortalecer o conhecimento científico.https://bit.ly/naruhodo-no-orelo

We talk with Dr. Luke Wilkins about his stenting algorithm for treating peripheral artery disease, including a step by step discussion of the decision tree when deciding whether or not to stent. --- CHECK OUT OUR SPONSOR Boston Scientific Eluvia Drug-Eluting Stent https://www.bostonscientific.com/en-US/medical-specialties/vascular-surgery/drug-eluting-therapies/eluvia/eluvia-clinical-trials.html?utm_source=oth_site&utm_medium=native&utm_campaign=pi-at-us-de_portfolio-hci&utm_content=n-backtable-n-backtable_site_eluvia_1&cid=n10008043 --- SHOW NOTES In this episode, our host Dr. Aparna Baheti interviews interventional radiologist Dr. Luke Wilkins about his treatment algorithm for Peripheral Arterial Disease (PAD). This algorithm is linked below, under “Resources.” Dr. Wilkins starts by explaining his treatment decisions for non-occlusive lesions. If the lesion is less than 10 cm he prefers to use directional atherectomy and percutaneous transluminal angioplasty (PTA). However, if the lesion is greater than 10 cm, directional atherectomy poses the risk of distal embolization, so he will only perform PTA. In both cases, he recommends using IVUS to evaluate the efficacy of the treatment and then proceeding with a drug-coated balloon (DCB) to prevent re-stenosis. On the other hand, if the disease is occlusive, Dr. Wilkins first attempts to cross the lesion. This can be achieved by going through microchannels with a guidewire or boring through the occlusion with a crossing device. If the lesion is unable to be crossed, he attempts subintimal recanalization. We discuss spontaneous re-entry into the true lumen, as well as re-entry devices like the Outback and the Pioneer catheters. We also take a detour into the Subintimal Arterial Flossing with Anterograde-Retrograde Intervention (SAFARI) technique that can be used if re-entry is challenging. After crossing is complete, Dr. Wilkins evaluates vessel diameter. In his experience, vessels that are wider than 5 mm have better stent patency, so he will place a drug eluting stent. In vessels of smaller diameters, Dr. Wilkins relies on other approaches such as interwoven stents with smaller diameters, directional atherectomy, and Tacks (to treat dissection flaps). Finally, Dr. Wilkins discusses medical management and follow-up care for PAD patients. He recommends dual antiplatelet therapy, smoking cessation, and if claudication was an initial concern, patient education on the importance of walking. He follows up with patients in 1, 6, and 9 months, and then annually. During each follow up appointment, he checks ABI, PVR, and arterial duplex for clinical improvement. --- RESOURCES PAD Stenting Algorithm Decision Tree: https://www.backtable.com/shows/vi/podcasts/200/pad-stenting-algorithm TASC Guidelines: https://journals.sagepub.com/doi/10.1177/1358863X15597877?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed Articles Mentioned: Schneider PA, Laird JR, Doros G, Gao Q, Ansel G, Brodmann M, Micari A, Shishehbor MH, Tepe G, Zeller T. Mortality not correlated with paclitaxel exposure: an independent patient-level meta-analysis of a drug-coated balloon. Journal of the American College of Cardiology. 2019 May 28;73(20):2550-63.   Secemsky EA, Kundi H, Weinberg I, Jaff MR, Krawisz A, Parikh SA, Beckman JA, Mustapha J, Rosenfield K, Yeh RW. Association of survival with femoropopliteal artery revascularization with drug-coated devices. JAMA cardiology. 2019 Apr 1;4(4):332-40.   Freisinger E, Koeppe J, Gerss J, Goerlich D, Malyar NM, Marschall U, Faldum A, Reinecke H. Mortality after use of paclitaxel-based devices in peripheral arteries: a real-world safety analysis. European heart journal. 2020 Oct 7;41(38):3732-9.

Drs Lidia Schapira and Antonio Wolff resume their discussion on the current research on DCIS and other forms of lower-risk early breast cancer, and how medical oncologists can work to create an optimal treatment plan. Relevant disclosures can be found with the episode show notes on Medscape.com (https://www.medscape.com/viewarticle/963167). The topics and discussions are planned, produced, and reviewed independently of our advertiser. This podcast is intended only for US healthcare professionals. Resources Abemaciclib Combined With Endocrine Therapy for the Adjuvant Treatment of HR+, HER2-, Node-Positive, High-Risk, Early Breast Cancer (monarchE) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7768339/ Tamoxifen for early breast cancer: an overview of the randomised trials https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(97)11423-4/fulltext Adjuvant Palbociclib for Early Breast Cancer: The PALLAS Trial Results (ABCSG-42/AFT-05/BIG-14-03) https://ascopubs.org/doi/10.1200/JCO.21.02554?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed Palbociclib for Residual High-Risk Invasive HR-Positive and HER2-Negative Early Breast Cancer—The Penelope-B Trial https://ascopubs.org/doi/10.1200/JCO.20.03639?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed Verzenio® (abemaciclib) Significantly Reduced the Risk of Cancer Returning in People with High Risk HR+, HER2- Early Breast Cancer https://investor.lilly.com/news-releases/news-release-details/verzenior-abemaciclib-significantly-reduced-risk-cancer Pfizer Provides Update on Phase 3 PALLAS Trial of IBRANCE® (palbociclib) Plus Endocrine Therapy in HR+, HER2- Early Breast Cancer https://www.pfizer.com/news/press-release/press-release-detail/pfizer-provides-update-phase-3-pallas-trial-ibrancer NATALEE: Phase III study of ribociclib (RIBO) + endocrine therapy (ET) as adjuvant treatment in hormone receptor–positive (HR+), human epidermal growth factor receptor 2–negative (HER2–) early breast cancer (EBC). https://ascopubs.org/doi/abs/10.1200/JCO.2019.37.15_suppl.TPS597 FDA Approval Summary: Abemaciclib With Endocrine Therapy for High-Risk Early Breast Cancer https://ascopubs.org/doi/full/10.1200/JCO.21.02742#:~:text=The%20US%20Food%20and%20Drug,%2D67%20score%20%E2%89%A5%2020%25. Adjuvant abemaciclib combined with endocrine therapy for high-risk early breast cancer: updated efficacy and Ki-67 analysis from the monarchE study https://www.annalsofoncology.org/action/showPdf?pii=S0923-7534%2821%2904494-X

In this episode we continue our discussion with Dr. Dajo Sanders (part 2 of 2), an individual whose skill and expertise in the realm of cycling performance are well developed. Dajo is a prolific researcher in many aspects of endurance training and specializes in the very distinct research cohort that is well-trained high-performance cyclists. He is also a member of the performance group at Team DSM where he uses his experience and knowledge to help World Tour cyclists perform at their absolute best.In this episode we discuss with Dajo his research and practice in monitoring training load in cyclists and also what cycling performance research he is excited about.Guest panelist:Dajo Sanders, PhDTwitter: @DajoSandersResearchgate: https://www.researchgate.net/profile/Dajo-Sanders-2LinkedIn: https://www.linkedin.com/in/dajo-sanders-ph-d-59112794/The podcast co-hosts:Jason Boynton, Ph.D.boyntoncoaching.comDamian Rusesemiprocycling.comCyrus Monkcyclistscientist.comInstagram: @cyclingperformanceclubFacebook: @cyclingperformanceclubTwitter: @cyclingclubpodLinkedIn: The Cycling Performance Club PodcastReferences:Methods of Monitoring Training Load and Their Relationships to Changes in Fitness and Performance in Competitive Road Cyclistshttps://journals.humankinetics.com/view/journals/ijspp/12/5/article-p668.xmlMaintaining Power Output with Accumulating Levels of Work Done Is a Key Determinant for Success in Professional Cyclinghttps://journals.lww.com/acsm-msse/Abstract/2021/09000/Maintaining_Power_Output_with_Accumulating_Levels.12.aspxHeat acclimation improves exercise performancehttps://journals.physiology.org/doi/full/10.1152/japplphysiol.00495.2010?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.orgHeat training increases exercise capacity in hot but not in temperate conditions: a mechanistic counter-balanced cross-over studyhttps://journals.physiology.org/doi/full/10.1152/ajpheart.00138.2015?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org

Dans cet épisode, nous parlons d'un lézard qui attend l'exact moment du jour pour changer d'habitat et éviter ainsi ces prédateurs. L'article : Le lézard dans l'herbe – Julien Grangier - Espèces n°42 - p.11 Pour aller plus loin : https://www.inaturalist.org/taxa/113753-Takydromus-viridipunctatus https://royalsocietypublishing.org/doi/10.1098/rsbl.2021.0388?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed

Grief increases inflammation, which can worsen health problems you already have and cause new ones. It batters the immune system, leaving you depleted and vulnerable to infection. The heartbreak of grief can increase blood pressure and the risk of blood clots. Who knew an emotional response to a major life event had such physical consequences? If you're new here, the phrase and mantra “ever forward” came from his father. His father's death left such a significant and traumatic imprint on Chase's heart, mind, and really his entire life, so much so that it became his reason for living. In this discussion, Chase sheds light on his nearly two-decade long battle with grief and bereavement, sharing his personal story of the very significant trauma he has experienced. He also incorporates what science has to say about the relationship between grief and our physical and mental states. Chase then shares a few things he's done to bring a sense of awareness to his grief and work through it.   Follow Chase on Instagram @chase_chewning Follow him on Twitter @chasechewning   Episode resources: Save 15% on any CBD product with code EVERFORWARD at www.CuredNutrition.com  The Body Keeps the Score https://amzn.to/3IPHLaw  Bereavement and complicated grief https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855369/ Complicated grief https://royalsocietypublishing.org/doi/10.1098/rstb.2017.0273?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed#d3e1100 Complicated greif and related bereavement issues for DSMR-5 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075805/  Field Trip Health ketamine-assisted psychotherapy clinics https://www.fieldtriphealth.com 

Why do people train for a marathon? Listen to sad music? Eat really spicy food? All of these activities induce a painful response, yet they also bring us pleasure. We often set ourselves up for negative experiences because it primes us for positive ones further down the line. There is a balance, a sweet spot if you will, between the amount of pleasure we experience and the suffering that it takes to get us there. World-renowned psychologist and author Paul Bloom, joins us on this episode to discuss his most recent book The Sweet Spot: The Pleasures of Suffering and the Search for Meaning (https://amzn.to/3Kmpweh). He challenges our definition of a fulfilling life, and why we actually NEED suffering to be part of it. We are so conditioned in our culture to only seek out pleasure that even the notion of reading about suffering was not particularly appealing to us, well to Tim - it turns out Kurt might be somewhat of a benign masochist! But from the get-go, Paul's compelling narrative convinced us that suffering can be motivating. Listen in and tell us if you think there is a sweet spot, and then reach out to us on email (info@behavioralgrooves.com), on Twitter (@behavioralgroov) or write us a quick review about the show (https://podcasts.apple.com/us/podcast/behavioral-grooves-podcast/id1303870112). Thanks!   Topics  (4:40) Welcome and speed round questions. (7:24) Why do we choose suffering? (11:24) Do we really only seek pleasure? (13:40) We often have mistaken ideas about what we want. (16:16) Looking beyond happiness; what we actually pursue for a meaningful life. (22:24) How can suffering help pleasure? (24:59) How being in a state of flow explains the sweet spot. (28:27) Why are people driven to climb Everest?  (32:32) What are the unpleasant sensations that people do not pursue? (34:37) Pain then pleasure or pleasure then pain? (36:13) The effect of the peak-end rule. (38:40) Why do we want to listen to sad music?  (45:11) Grooving Session discussing how Paul's work can improve our lives.   © 2022 Behavioral Grooves   Links “The Sweet Spot: The Pleasures of Suffering and the Search for Meaning” by Paul Bloom: https://amzn.to/3Kmpweh  Shaquille O'Neal: https://en.wikipedia.org/wiki/Shaquille_O%27Neal “Just think: The challenges of the disengaged mind” by Wilson et al (2014): https://www.science.org/doi/10.1126/science.1250830?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed  Paul Rozin: https://web.sas.upenn.edu/rozin/ “Flow: The Psychology of Optimal Experience” by Mihaly Csikszentmihalyi: https://amzn.to/3qyLRgB   “A psychologically rich life: Beyond happiness and meaning” by Oishi and Westage (2021): https://psycnet.apa.org/record/2021-74886-001 “Anticipation and the valuation of delayed consumption.” by George Loewenstein (1987): https://www.jstor.org/stable/2232929  Episode 67, George Loewenstein: On a Functional Theory of Boredom:  https://behavioralgrooves.com/episode/george-loewenstein-on-a-functional-theory-of-boredom/ “When More Pain Is Preferred to Less: Adding a Better End” by Kahneman et al (1993): https://journals.sagepub.com/doi/abs/10.1111/j.1467-9280.1993.tb00589.x  Jeremy Bentham: https://en.wikipedia.org/wiki/Jeremy_Bentham  Richard Tedeschi, The Science of Post-Traumatic Growth: https://scottbarrykaufman.com/podcast/richard-tedeschi-the-science-of-post-traumatic-growth/  The Prophet by Khalil Gibran: https://amzn.to/329fN9O  Episode 207, Jonathan Mann: Is it Possible to Design an Experience? https://behavioralgrooves.com/episode/jonathan-mann-is-it-possible-to-design-an-experience/   Musical Links  Adele “Someone Like You”: https://www.youtube.com/watch?v=hLQl3WQQoQ0  Alice Cooper “Poison”: https://www.youtube.com/watch?v=Qq4j1LtCdww  Pink Floyd “On The Turning Away”: https://www.youtube.com/watch?v=ojf18wT_Xtk  Eminem “Lose Yourself”: https://www.youtube.com/watch?v=_Yhyp-_hX2s  The Proclaimers “I'm Gonna Be (500 Miles)”: https://www.youtube.com/watch?v=tbNlMtqrYS0  Joan Armatrading “Consequences”: https://www.youtube.com/watch?v=Otq9VBa6a0s  David Bowie & Nine Inch Nails “Hurt”: https://www.youtube.com/watch?v=fhhEHuChFck&ab_channel=redsails2008  Billy Joel “Piano Man”: https://www.youtube.com/watch?v=gxEPV4kolz0  Violent String Quartet “Bad Guy”: https://www.youtube.com/watch?v=PWUbCwmBmgE 

In this episode of ToxChats, Dr. Daniel Rudmann, an ACVP board-certified investigative and toxicologic pathologist and translational medicine scientist with over 20 years of experience in drug discovery and development and current director of digital pathology at Charles River Laboratories, is interviewed. Dr. Rudmann discusses how advances in digital pathology and machine learning are improving toxicology pathology workflows.For further information on digital pathology in drug discovery, we encourage you to check out the following links:1. Society of Toxicologic Pathology Digital Pathology and Image Analysis Special Interest Group Article*: Opinion on the Application of Artificial Intelligence and Machine Learning to Digital Toxicologic Pathologyhttps://journals.sagepub.com/doi/10.1177/0192623319881401?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed 2. BIGPICTURE is a public-private partnership funded by the EU Innovative Medicines Initiative (IMI) bringing together academic institutions, small- and medium-sized enterprises, public organizations, pharmaceutical companies, and a large network of partners.https://bigpicture.eu/

A recent paper was published providing a narrative review of the literature surrounding Youth Weightlifting. The authors include Dr. Mike Stone, Dr. Kyle Pierce, and Dr. Guy Hornsby. Instead of discussing this paper and providing my own commentary, I figured we could get the three of them on the show to discuss the topic even further!Enjoy.The paper: https://journals.sagepub.com/doi/10.1177/19417381211056094?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmedDr. Stone: StoneM@mail.etsu.eduDr. Pierce: Kyle.Pierce@lsus.eduDr. Guy Hornsby: William.Horsby@mail.wvu.eduhttps://twitter.com/CoachGuytonhttps://www.instagram.com/coachguyton/https://www.instagram.com/wvweightlifting/Follow me:https://www.instagram.com/josh_philwl/

This week sleep science expert Dr Baland Jalal joins us to chat about sleep paralysis & dig into his research! You can WATCH the podcast over on our YouTube channel: http://youtube.com/SciGuys Help keep the show running by supporting us on Patreon! http://patreon.com/sciguys If you'd like to see more of us, follow our socials! Facebook http://facebook.com/SciGuysPod Twitter http://twitter.com/SciGuysPod Instagram http://instagram.com/SciGuysPod Follow the SCI GUYS @notcorry / @jampkin / @lukecutforth References & Further Reading Dr Baland Jalal https://psychology.fas.harvard.edu/people/baland-jalal https://www.neuroscience.cam.ac.uk/directory/profile.php?bj272 https://www.researchgate.net/profile/Baland-Jalal/publication/262397186_Evidence_for_Tai_Chi_as_a_Therapeutic_Mind-Body_Intervention_for_Sleep_A_Commentary_on_Raman_et_al/links/0c9605379e7ea0f3c8000000/Evidence-for-Tai-Chi-as-a-Therapeutic-Mind-Body-Intervention-for-Sleep-A-Commentary-on-Raman-et-al.pdf MR Therapy https://www.frontiersin.org/articles/10.3389/fpsyg.2016.00028/full https://www.frontiersin.org/articles/10.3389/fneur.2020.00922/full Sleep Paralysis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8060736/#!po=22.4138 https://www.tandfonline.com/doi/pdf/10.1080/00207148108409169?needAccess=true https://journals.sagepub.com/doi/10.1177/1363461505050710?url_ver=Z39.88-2003 https://www.thecut.com/2016/07/a-neuroscientist-tried-to-help-me-overcome-my-sleep-paralysis.html https://www.researchgate.net/profile/Baland-Jalal/publication/258831277_A_Comparison_of_Self-Report_and_Interview_Methods_for_Assessing_Sleep_Paralysis_A_Pilot_Investigation_in_Denmark_and_the_United_States/links/0deec52ff95124e325000000/A-Comparison-of-Self-Report-and-Interview-Methods-for-Assessing-Sleep-Paralysis-A-Pilot-Investigation-in-Denmark-and-the-United-States.pdf

I apologize in advance for the science geekiness of this podcast.Kieran Moore, formally known as Dr Kieran Moore, continues to spread flagrant science denying conspiracy theory rhetoric.The Wall Street Journal summarizes the results from the Baylor Cardiology College of medicine in Houston, verifying that vaccine induced immunity is forcing our immune systems to target healthy heart cells, resulting in permanent disability and death.The Canadian departments of public health and the Canadian media are able to provide by the minute updates re COVID infections and deaths, yet are unable to accommodate even weekly updates re vaccine injury and death.Podcast available on all of your favourite podcast platforms (iTunes, Google Play, Spotify, etc). You can also listen to the podcast in your browser directly from the CH1.ca platformPodcast NotesKieran Moore, Tyrant - Wall Street Journal - You immune system is targeting your own heart - https://www.wsj.com/articles/researchers-probe-link-between-covid-19-vaccines-and-myocarditis-1163629002Wall Street Journal - https://www.ahajournals.org/doi/full/10.1161/CIRCULATIONAHA.121.056135?rfr_dat=cr_pub%20%200pubmed&url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.orgHealth Canada Serious Vaccine and Injury Rate Data - https://health-infobase.canada.ca/covid-19/vaccine-safety/ This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit andrewrouchotas.substack.com

We are back from the grave for this halloween episode. On the 2 year anniversary of Viral Load we dive into the wonderful world of monkeypox. Tune in to find out why you should care about this boil inducing disease. And whatever you do this hallows eve don't pet prairie dogs!sources:https://www.statnews.com/2021/07/20/more-than-200-people-in-u-s-being-monitored-for-possible-monkeypox-exposure-cdc-says/https://www.wsbtv.com/news/local/atlanta/1st-us-case-monkeypox-comes-traveler-flying-through-atlanta/BWBQZ5OIV5ANRP7MMOLJJMHF5U/https://www.cdc.gov/poxvirus/monkeypox/index.htmlhttps://www.sciencedirect.com/topics/neuroscience/monkeypoxhttps://pubmed.ncbi.nlm.nih.gov/22041995/https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0187089https://pubmed.ncbi.nlm.nih.gov/33167496/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857192/https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0007791https://www.sciencedirect.com/science/article/pii/S0264410X2030579Xhttps://www.pnas.org/content/107/37/16262https://www.sciencedirect.com/topics/medicine-and-dentistry/smallpox-vaccinehttps://www.nejm.org/doi/10.1056/NEJMoa032299?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0www.ncbi.nlm.nih.govhttps://www.cdc.gov/mmwr/preview/mmwrhtml/mm5227a5.htmhttps://www.the-scientist.com/news-opinion/texas-monkeypox-case-underscores-need-for-better-surveillance-69045http://outbreaknewstoday.com/monkeypox-drc-reports-600-cases-in-past-six-weeks-97477/https://emedicine.medscape.com/article/1134714-overviewhttps://www.statnews.com/2021/07/20/more-than-200-people-in-u-s-being-monitored-for-possible-monkeypox-exposure-cdc-says/https://www.cdc.gov/poxvirus/monkeypox/outbreak.htmlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857192/

U of Oregon Article:  https://www.oregonlive.com/trackandfield/2021/10/women-athletes-allege-body-shaming-within-oregon-ducks-track-and-field-program.html   Body composition of elite athletes: https://journals.sagepub.com/doi/10.1177/036354658301100604?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed&   Overtraining or Relative energy deficiency? https://pubmed.ncbi.nlm.nih.gov/34181189/   Athlete triad in female and male ultrarunners https://pubmed.ncbi.nlm.nih.gov/34232162/   Position stance and overview of RED-S:  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146210/

In this episode, host Dr Laurence Sperling speaks with Katherine Wilemon, founder of the FH Foundation. Relevant disclosures can be found with the episode show notes on Medscape.com (https://www.medscape.com/viewarticle/958283). The topics and discussions are planned, produced, and reviewed independently of our advertiser. This podcast is intended only for US healthcare professionals. Resources The Agenda for Familial Hypercholesterolemia: A Scientific Statement From the American Heart Association https://www.ahajournals.org/doi/10.1161/CIR.0000000000000297?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed Familial Hypercholesterolemia Foundation https://thefhfoundation.org/ Cascade Registry https://thefhfoundation.org/fh-research/registry Finding missed cases of familial hypercholesterolemia in health systems using machine learning https://www.nature.com/articles/s41746-019-0101-5 Genetic testing in dyslipidemia: A scientific statement from the National Lipid Association https://www.acc.org/latest-in-cardiology/ten-points-to-remember/2020/08/27/13/28/genetic-testing-in-dyslipidemia Genetic Testing for Managing Dyslipidemia https://www.acc.org/Latest-in-Cardiology/Articles/2020/11/13/20/26/Genetic-Testing-for-Managing-Dyslipidemia

Thanks to Basepaws for sponsoring this episode. Check out Basepaws here: https://basepaws.com/?rfsn=6159575.bff641“It Was A Dark & Stormy Month" lumbers along with more frightful topics and frightfully bad poetry!This week, an oft-requested and much anticipated topic: cats! These weird little goblins can steal our hearts even while infesting us with behavior-altering, poop-dwelling parasites! We must really love 'em! Need more Deboki in your life? Follow her on Twitter: @okidoki_boki! There you can find links to the myriad of projects she's involved in!Head to https://www.patreon.com/SciShowTangents to find out how you can help support SciShow Tangents, and see all the cool perks you'll get in return, like bonus episodes and a monthly newsletter!A big thank you to Patreon subscribers Eclectic Bunny and Garth Riley for helping to make the show possible!Follow us on Twitter @SciShowTangents, where we'll tweet out topics for upcoming episodes and you can ask the science couch questions! While you're at it, check out the Tangents crew on Twitter: Ceri: @ceriley Sam: @im_sam_schultz Hank: @hankgreen[Truth or Fail]Fact 1:https://phys.org/news/2021-07-dogs-people-lying.htmlFact 2:https://www.sciencedirect.com/science/article/abs/pii/S0003347296903206https://theaggie.org/2021/09/14/study-finds-domestic-cats-prefer-freeloading-to-working-for-food/Fact 3:https://www.eurekalert.org/news-releases/923830https://www.theatlantic.com/science/archive/2021/07/cat-genomes/619587/[Fact Off]Cats in development of cochlear implantshttps://jamanetwork.com/journals/jamaotolaryngology/fullarticle/1688121https://psycnet.apa.org/record/1931-04076-001https://journals.sagepub.com/doi/10.1177/000348947208100514?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmedhttps://journals.sagepub.com/doi/10.1177/000348947308200407https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4921065/https://www.jstor.org/stable/pdf/3220685.pdfhttps://www.mayoclinic.org/tests-procedures/cochlear-implants/about/pac-20385021[Ask the Science Couch]Cat tail movementshttps://www.nationalgeographic.com/pages/article/animals-behavior-cats-tail-body-languagehttps://brill.com/view/journals/beh/56/1-2/article-p69_3.xml  https://pubmed.ncbi.nlm.nih.gov/7696400/https://pubmed.ncbi.nlm.nih.gov/2074215/https://www.sciencedirect.com/science/article/abs/pii/S0166432897001010http://www.architalbiol.org/index.php/aib/article/view/138271/[Butt One More Thing]Cats sitting and not flipping over litter boxeshttps://www.sciencedirect.com/science/article/abs/pii/S0168159114002366?via%3Dihub

Learn about why you eat more when you're tired; a legendary submerged Egyptian city; and a trick for keeping the peace. Lack Of Sleep Really Does Make You Eat More by Ashley Hamer Sleep Munchies: Why It's Harder To Resist Snacks When We're Tired. (2016, March 2). NPR.org. https://www.npr.org/sections/thesalt/2016/03/02/468933610/sleep-munchies-why-its-harder-to-resist-snacks-when-were-tired ‌ Circadian Surprise: How Our Body Clocks Help Shape Our Waistlines. (2015, March 10). NPR.org. https://www.npr.org/sections/thesalt/2015/03/10/389596946/circadian-surprise-how-our-body-clocks-help-shape-our-waistlines  Brief Communication: Sleep Curtailment in Healthy Young Men Is Associated with Decreased Leptin Levels, Elevated Ghrelin Levels, and Increased Hunger and Appetite | Annals of Internal Medicine. (2021). Annals of Internal Medicine. https://www.acpjournals.org/doi/abs/10.7326/0003-4819-141-11-200412070-00008  Hanlon, E. C., Tasali, E., Leproult, R., Stuhr, K. L., Doncheck, E., de Wit, H., Hillard, C. J., & Van Cauter, E. (2016). Sleep Restriction Enhances the Daily Rhythm of Circulating Levels of Endocannabinoid 2-Arachidonoylglycerol. Sleep, 39(3), 653–664. https://doi.org/10.5665/sleep.5546 ‌ Insufficient Sleep Undermines Dietary Efforts to Reduce Adiposity | Annals of Internal Medicine. (2021). Annals of Internal Medicine. https://www.acpjournals.org/doi/10.7326/0003-4819-153-7-201010050-00006?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed&  We just found an ancient Greek military ship in the legendary SUBMERGED Egyptian city Thônis-Heracleion by Steffie Drucker  Berman, R. (2021, July 28). Ancient Greek military ship found in legendary, submerged Egyptian city. Big Think; Big Think. https://bigthink.com/surprising-science/thonis-heracleion  ‌Sharpe, E. (2016, May 16). British Museum dips its toes into world of underwater archaeology. Theartnewspaper.com; The Art Newspaper. https://www.theartnewspaper.com/news/british-museum-dips-its-toes-into-world-of-underwater-archaeology  ‌Reuters. (2021, August 10). Egypt finds ancient military vessel, Greek graves in sunken city. Reuters; Reuters. https://www.reuters.com/world/africa/egypt-finds-ancient-military-vessel-greek-graves-sunken-city-2021-07-19/  ‌In Photos: The sunken city of Thônis-Heracleion in Alexandria reveals new archaeological treasures - Heritage. (2020). Ahram Online; Ahram Online. https://english.ahram.org.eg/NewsContentP/9/417416/Heritage/In-Photos-The-sunken-city-of-Th%C3%83%C2%B4nisHeracleion-in-A.aspx  Writing about relationship conflicts from a third-person perspective can keep the peace by Steffie Drucker Expressive writing reduces relationship conflict and aggression during pandemic. (2021, August 10). EurekAlert! https://www.eurekalert.org/news-releases/924973  Rodriguez, L. M., Stewart, S. H., & Neighbors, C. (2021). Effects of a brief web-based interpersonal conflict cognitive reappraisal expressive-writing intervention on changes in romantic conflict during COVID-19 quarantine. Couple and Family Psychology: Research and Practice. Advance online publication. https://doi.org/10.1037/cfp0000173  Follow Curiosity Daily on your favorite podcast app to learn something new every day withCody Gough andAshley Hamer. Still curious? Get exclusive science shows, nature documentaries, and more real-life entertainment on discovery+! Go to https://discoveryplus.com/curiosity to start your 7-day free trial. discovery+ is currently only available for US subscribers. See omnystudio.com/listener for privacy information.

The benefits of earthing are profound! Check out the references Susana has provided below and visit her website to learn more about working this earthy and smart Coach. Chevalier G. (2015). The effect of grounding the human body on mood. Psychological reports, 116(2), 534–542. https://doi.org/10.2466/06.PR0.116k21w5. Chevalier, G., Sinatra, S. T., Oschman, J. L., & Delany, R. M. (2013). Earthing (grounding) the human body reduces blood viscosity—a major factor in cardiovascular disease. The journal of alternative and complementary medicine, 19(2), 102-110. https://www.liebertpub.com/doi/10.1089/acm.2011.0820?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmedChevalier, G., Sinatra, S. T., Oschman, J. L., Sokal, K., & Sokal, P. (2012). Earthing: health implications of reconnecting the human body to the earth's surface electrons. Journal of environmental and public health, 2012. https://pubmed.ncbi.nlm.nih.gov/22757749/Ghaly, M., & Teplitz, D. (2004). The biologic effects of grounding the human body during sleep as measured by cortisol levels and subjective reporting of sleep, pain, and stress. Journal of alternative and complementary medicine (New York, N.Y.), 10(5), 767–776. https://doi.org/10.1089/acm.2004.10.767Menigoz, W., Latz, T. T., Ely, R. A., Kamei, C., Melvin, G., & Sinatra, D. (2020). Integrative and lifestyle medicine strategies should include Earthing (grounding): Review of research evidence and clinical observations. EXPLORE, 16(3), 152-160. https://www.sciencedirect.com/science/article/pii/S1550830719305476?via%3DihubOschman, J. L., Chevalier, G., & Brown, R. (2015). The effects of grounding (earthing) on inflammation, the immune response, wound healing, and prevention and treatment of chronic inflammatory and autoimmune diseases. Journal of Inflammation Research, 8, 83.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4378297/

Dr. Jordan Feigenbaum and Dr. Herman Pontzer discuss the Constrained Energy Expenditure Model, Metabolism, and more! Burn: https://www.amazon.com/Burn-Research-Really-Calories-Healthy/dp/0525541527 Papers: https://pubmed.ncbi.nlm.nih.gov/34385400/ https://journals.physiology.org/doi/full/10.1152/physiol.00027.2018?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org 2-Day Barbell Medicine Seminar: https://www.barbellmedicine.com/seminars/ Pain and Rehab Seminar: https://www.barbellmedicine.com/shop/events/pain-rehab-2-day-virtual-seminar/ For more of our stuff: Podcasts: goo.gl/X4H4z8 Website: www.barbellmedicine.com Instagram: @austin_barbellmedicine @jordan_barbellmedicine @leah_barbellmedicine @vaness_barbellmedicine @untamedstrength @michael_barbellmedicine @derek_barbellmedicine @hassan_barbellmedicine @michael_amato_barbellmedicine @charlie_barbellmedicine @alex_barbellmedicine @tomcampitelli Email: info@barbellmedicine.com Supplements/Templates/Seminars: www.barbellmedicine.com/shop/ Forum: forum.barbellmedicine.com/

In this episode, Marc and Mo are joined by special guest Javad Parvizi (James Edwards Professor of Orthopaedic Surgery at the Sidney Kimmel School of Medicine at the Rothman Institute at Thomas Jefferson University in Philadelphia) in a thought-provoking discussion on the goals and impact of international efforts to achieve consensus and standardization in orthopaedic care, with a specific focus on guidelines related to periprosthetic joint infection and venous thromboembolism. OrthoJOE Mailbag: feedback, comments, and suggestions from our audience can be sent to orthojoe@jbjs.org Links: Second International Consensus Meeting (ICM) on Musculoskeletal Infection. https://icmphilly.com/ Parvizi J, Gehrke T, Chen AF. Proceedings of the International Consensus on Periprosthetic Joint Infection. Bone Joint J. 2013 Nov;95-B(11):1450-2. https://online.boneandjoint.org.uk/doi/full/10.1302/0301-620X.95B11.33135?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org

Cam Akers achilles tendon rupture breakdown Citations: https://journals.sagepub.com/doi/10.1177/1071100720969633?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed& https://journals.sagepub.com/doi/full/10.1177/2325967119830139 --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app --- Send in a voice message: https://anchor.fm/edwin-porras/message Support this podcast: https://anchor.fm/edwin-porras/support

In this episode you'll learn which medications are typically used to treat those with Selective Mutism, various studies conducted on the effectiveness of medication for those with SM, and you'll hear about our journey with medication and how our thoughts on medication have changed over time.   For more information about Selective Mutism, visit www.smhelp.org or email smhelp2020@gmail.com   Here are the links to the studies mentioned in this podcast: https://www.jaacap.org/article/S0890-8567(09)63935-6/pdf https://www-sciencedirect-com.portal.lib.fit.edu/science/article/abs/pii/S089085670963433X https://journals-sagepub-com.portal.lib.fit.edu/doi/10.1177/070674370805301010?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed https://link-springer-com.portal.lib.fit.edu/chapter/10.1007%2F978-3-7091-1501-5_17

In this episode, Dr Mari Thomas and Professor Jan Beyer-Westendorf discuss practical considerations for how physicians should take patient preference into account when deciding on an anticoagulant for the treatment of cancer-associated thrombosis. Further details: • Information on patient persistence with oral anticoagulant treatment compared with parenteral can be found here: https://onlinelibrary.wiley.com/doi/full/10.1002/rth2.12002 • Details on the COSIMO study can be found here: https://thrombosisjournal.biomedcentral.com/articles/10.1186/s12959-018-0176-2 and https://ashpublications.org/blood/article/134/Supplement_1/2161/427953/Baseline-Characteristics-and-Clinical-Outcomes • The American Society of Hematology 2021 guidelines for management of venous thromboembolism: prevention and treatment in patients with cancer guidelines can be found here: https://ashpublications.org/bloodadvances/article-lookup/doi/10.1182/bloodadvances.2020003442 • The American Society of Clinical Oncology venous thromboembolism prophylaxis and treatment in patients with cancer clinical practice guideline update can be found here: https://ascopubs.org/doi/10.1200/JCO.19.01461?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed • The 2019 International Initiative on Thrombosis and Cancer clinical practice guidelines for the treatment and prophylaxis of venous thromboembolism in patients with cancer can be found here: https://linkinghub.elsevier.com/retrieve/pii/S1470-2045(19)30336-5 • The International Society on Thrombosis and Haemostasis guidelines on the role of direct oral anticoagulants in the treatment of cancer-associated venous thromboembolism can be found here: https://doi.org/10.1111/jth.14219 • The 2019 European Society of Cardiology guidelines for the diagnosis and management of acute pulmonary embolism, developed in collaboration with the European Respiratory Society can be found here: https://academic.oup.com/eurheartj/article-lookup/doi/10.1093/eurheartj/ehz405 Recording approval code: PP-M_RIV-ALL-0195-1; Shownotes approval code: PP-M_RIV-ALL-0196-1

We talk with Dr. David Cognetti about sialendoscopy including the importance of patient selection as well as tips and tricks for success. --- EARN CME Reflect on how this Podcast applies to your day-to-day and earn AMA PRA Category 1 CMEs: https://earnc.me/mmBz4k --- SHOW NOTES In this episode, Dr. David Cognetti joins Dr. Gopi Shah and Dr. Ashley Agan to discuss the workup for salivary gland obstruction and inflammation, the emerging use of sialendoscopy, and different approaches to sialolithotomy. First, the doctors highlight key aspects of physical examination: observing swelling around the glands, bimanually palpating for stones, and massaging the glands to observe the quantity and quality of saliva produced. For imaging, Dr. Cognetti typically orders CT for suspected stones and MRI for suspected inflammatory disorders. He describes the process of sialography, noting that the outcome may be technician-dependent. The doctors also discuss inflammatory cases where laboratory tests may be appropriate and can reveal autoimmune disorders. Then, Dr. Cognetti describes his preferred sialendoscopy tools and how he uses them to cannulate and dilate the parotid and submandibular ducts during surgery. He emphasizes the fragile nature of the scopes and the need to protect them from damage. For sialolithotomy, he describes various methods of lithotripsy and ways to prevent thermal damage. He also discusses how he deals with duct perforation and how he decides whether or not to use stents. The doctors bring up management of patient expectations throughout the episode, as outcomes may vary depending on the individual's history of stone recurrence. --- RESOURCES “Sonopalpation: A Novel Application of Ultrasound for Detection of Submandibular Calculi” - https://journals.sagepub.com/doi/10.1177/0194599814545736?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed “Limited Distal Sialodochotomy to Facilitate Sialendoscopy of the Submandibular Duct” - https://onlinelibrary.wiley.com/doi/full/10.1002/lary.23801 4th Annual Jefferson Sialendoscopy Course- https://cme.jefferson.edu/content/sialendoscopy2021#group-tabs-node-course-default1

El Índice ROX fue desarrollado por el Dr. Roca y Col. para ayudar en la predicción de resultados clínicos de pacientes tratados con cánula nasal de alto flujo (CNAF). Este se calcula por la dividiendo la saturación de oxígeno (SatO2) con el oxímetro de pulso y la fracción inspirada de oxígeno (FiO2) y este resultado lo dividimos por la frecuencia respiratoria (FR). IROX = [SpO2/FiO2]/FR Este fue un estudio de cohorte observacional prospectivo multicéntrico de 2 años que incluyó pacientes con neumonía tratados con cánula nasal de alto flujo. Se evaluó el punto de corte más específico del índice ROX para predecir el fracaso y el éxito de la necesidad o no de intubación. 1. ROX mayor o igual a 4,88 después del inicio de la cánula nasal de alto flujo se asoció sistemáticamente con un menor riesgo de intubación. 2. Un ROX menor de 2,85, menor de 3,47 y menor de 3,85 a las 2, 6 y 12 horas de iniciación de la con cánula nasal de alto flujo, respectivamente, fueron predictores de falla de la cánula nasal de alto flujo. 3. Los pacientes que fracasaron presentaron un menor aumento de los valores del índice ROX a lo largo de las 12 horas. Entre los componentes del índice, la saturación de oxígeno medida por oximetría de pulso / FiO2 tuvo un peso mayor que la frecuencia respiratoria. Un buen resumen de información práctica para quedaros después de la revisión de la literatura seria: 1. Un índice de ROX ≥4,88 a las 2, 6 y 12 horas es un buen predictor de que el paciente no necesitará intubación orotraqueal. 2. Un índice de ROX entre 3,85-4,87 requiere monitoreo estrecho. 3. Un índice de ROX

Are hot flashes taking over your life? Eek! Dr. Liz reviews two studies about hypnosis for hot flashes and lets you know if it's effective and if so, how effective! Study 1:  Clinical hypnosis in the treatment of postmenopausal hot flashes: a randomized controlled trial by Gary Elkins, William Fisher, Aimee K Johnson, Janet S Carpenter, Timothy Z Keith 2013 Mar;20(3):291-8. doi: 10.1097/gme.0b013e31826ce3ed. https://journals.lww.com/menopausejournal/Abstract/2013/03000/Clinical_hypnosis_in_the_treatment_of.11.aspx Study 2:  Randomized Trial of a Hypnosis Intervention for Treatment of Hot Flashes Among Breast Cancer Survivors by Gary Elkins, Joel Marcus, Vered Stearns, Michelle Perfect, M. Hasan Rajab, Christopher Ruud, Lynne Palamar, Timothy Keith https://ascopubs.org/doi/full/10.1200/JCO.2008.16.6389?rfr_dat=cr_pub%3Dpubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org -------------- Do you have Chronic Insomnia? Find out more about Dr. Liz’s Better Sleep Program at https://bit.ly/sleepbetterfeelbetter -------------------- See more about Dr. Liz and get Free hypnosis files at http://bit.ly/drlizhypnosis Search episodes at the Podcast Page http://bit.ly/HM-podcast Help yourself with Hypnosis Downloads by Dr. Liz! http://bit.ly/HypnosisMP3Downloads Twitter @DrLizBonet#hypnotizemepodcast | YouTube  |  FB  |  LinkedIn --------- A problem shared is a problem halved.In person and Online hypnosis for healing and transformation. Schedule your free consultation at https://www.drlizhypnosis.com. Listened to in over 140 countries, Hypnotize Me is the podcast about hypnosis, transformation, and healing. Certified hypnotherapist and Licensed Mental Health Counselor, Dr. Elizabeth Bonet, discusses the research behind hypnosis, interviews professionals doing transformational work, and talks to individuals who have had hypnosis. Free hypnoses are also given from time to time. If you're interested in learning more about the magic of hypnosis, psychotherapy and mindfulness, this is the perfect place to feed your fascination! Thank you for tuning in! Please subscribe to auto-download new episodes to your listening device.

Folge 42 – Mikrobiom Es geht einmal mehr um unsere kleinen Mitbewohner, Mikroorganismen in uns und um uns herum. Gesprächige Organe, Babykatzen und Einflüsse aus frühesten Kindheitserfahrungen. Und am Ende steht einmal mehr: du bist, was du isst. Mehr als wir alle denken. Hör rein – wir wünschen viel Spaß bei dieser Folge breaking vet! Kontakt: breakingvet@gmail.com Hintergrund: https://www.atsjournals.org/doi/10.1513/AnnalsATS.201503-133AW?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed https://www.purinainstitute.com/sites/g/files/auxxlc381/files/2018-05/Development%20of%20the%20Oral%20Microbime%20in%20Kittens%20-%20Julie%20K.%20Spears,.pdf https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-016-0169-y Musik: –––––––––––––––––––––––––––––– Track: Sprinkles — Johny Grimes [Audio Library Release] Music provided by Audio Library Plus Watch: https://youtu.be/BHUAx6hpqaI Free Download / Stream: https://alplus.io/Sprinkles

On this very exciting episode of PAINdemonium, we have the former Acting Commissioner of the FDA, Dr. Stephen Ostroff. Dr. Ostroff is a public health leader who has spent years on the ground in countries around the world effecting health outcomes for the better. Dr. Ostroff provides an inside look into the processes at the FDA for approving opioids and other pain medication and what mistakes we can learn from going forward. Please leave a review and subscribe! We hope you enjoy this episode.    Article Discussed: https://www-nejm-org.proxy1.lib.tju.edu/doi/10.1056/NEJMsr1601307?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200www.ncbi.nlm.nih.gov  

In this episode, Martin talks to Professor Loreen Herwaldt, from the University of Iowa Carver College of Medicine.  We discuss three new papers on hand hygiene compliance that have come from data originally collected that looked at the implementation of surveillance feedback and barrier precautions for a study published in the NEJM (Huskins, W.C., et al., Intervention to reduce transmission of resistant bacteria in intensive care. N Engl J Med, 2011. 364(15): p. 1407-18. https://www.nejm.org/doi/10.1056/NEJMoa1000373?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200www.ncbi.nlm.nih.gov). Two new papers focusing on hand hygiene aspects of care have already been published and a third has also been accepted. The first looked at hand hygiene compliance at critical points of care (Chang, N.N., et al., Hand Hygiene Compliance at Critical Points of Care. Clin Infect Dis, 2021. 72(5): p. 814-820. https://doi.org/10.1093/cid/ciaa130) and the second examined the sequence of patient care (Chang, N.C., et al., Hand hygiene and the sequence of patient care. Infect Control Hosp Epidemiol, 2021: p. 1-6. https://doi.org/10.1017/ice.2021.82). The third paper that we discuss is a forthcoming paper on the time taken to perform hand hygiene.

In this episode, Martin talks to Professor Loreen Herwaldt, from the University of Iowa Carver College of Medicine.  We discuss three new papers on hand hygiene compliance that have come from data originally collected that looked at the implementation of surveillance feedback and barrier precautions for a study published in the NEJM (Huskins, W.C., et al., Intervention to reduce transmission of resistant bacteria in intensive care. N Engl J Med, 2011. 364(15): p. 1407-18. https://www.nejm.org/doi/10.1056/NEJMoa1000373?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200www.ncbi.nlm.nih.gov). Two new papers focusing on hand hygiene aspects of care have already been published and a third has also been accepted. The first looked at hand hygiene compliance at critical points of care (Chang, N.N., et al., Hand Hygiene Compliance at Critical Points of Care. Clin Infect Dis, 2021. 72(5): p. 814-820. https://doi.org/10.1093/cid/ciaa130) and the second examined the sequence of patient care (Chang, N.C., et al., Hand hygiene and the sequence of patient care. Infect Control Hosp Epidemiol, 2021: p. 1-6. https://doi.org/10.1017/ice.2021.82). The third paper that we discuss is a forthcoming paper on the time taken to perform hand hygiene.

Mario Bizzini is a sports PT and researcher based in Switzerland. He has his PhD from the Oslo SportsTrauma and Research Center from the Norwegian School of Medicine and a Masters of Science from the University of Pittsburg. He's worked in 5 World Cups and 3 Olympics.  He spent 12 years working for the FIFA Medical Research and Clinical Assessment.  Today, he works as a clinician and researcher splitting his time at the Schulthess Clinic and the Human Performance Lab and Swiss Concussion Center.Follow for updates:https://www.instagram.com/physicaltherapy4athletes/Exercise-Based Knee and Anterior Cruciate Ligament Injury Prevention.https://www.jospt.org/doi/10.2519/jospt.2018.0303?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmedImplementing Injury Prevention https://www.aspetar.com/journal/upload/PDF/2018671906.pdfFIFA 11+: an effective programme to prevent football injuries in various player groups worldwide-a narrative review.https://bjsm.bmj.com/content/49/9/577.long **RETURN TO SPORT 2016 Consensus statement on return to sport from the First World Congress in Sports Physical Therapyhttps://bjsm.bmj.com/content/50/14/853.longReturn to Sport After Anterior Cruciate Ligament Injury: Panther Symposium ACL Injury Return to Sport Consensus Group.https://journals.sagepub.com/doi/10.1177/2325967120930829?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmedPhoto credit: Mario Bizzini Music: Adding The Sun by Kevin MacLeodLink: https://incompetech.filmmusic.io/song/5708-adding-the-sunLicense: https://filmmusic.io/standard-license  

Brandon chats with Kate Wason, Sports PT Resident at VCU, live from Richmond about Anterior Cruciate Ligament (ACL) injuries discussing risk factors, surgical considerations, appropriate rehabilitation, and much more.   Resources Mentioned Mike Reinold and Lenny Macrina Erik Miera's Website Erik Meira's Article on Quad Index with ACL BJSM ACL Guidelines APTA Knee Ligament Sprain Clinical Practice Guidelines Steph Allen's Instagram Page Clinical Athlete ACL Injury Prevention   Evidence Referenced https://www.jospt.org/doi/pdf/10.2519/jospt.2018.0303 https://www.ncbi.nlm.nih.gov/pubmed/28990491 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405414/ https://www.nejm.org/doi/10.1056/NEJMoa0907797?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dwww.ncbi.nlm.nih.gov https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3553934/    Other Podcast Episodes on the ACL https://podcasts.apple.com/us/podcast/378-mick-hughes-randall-cooper-melbourne-acl-rehabilitation/id532717264?i=1000419015693  https://podcasts.apple.com/us/podcast/426-dr-peter-fabricant-pediatric-acl-injuries/id532717264?i=1000434124371  https://podcasts.apple.com/us/podcast/physio-edge-079-how-to-rehabilitate-acl-injuries-dr/id454714085?i=1000413276313  https://www.clinicaledge.co/podcast/physio-edge-podcast/physio-edge-052-conservative-or-surgical-management-for-acl-injuries-with-enda-king https://soundcloud.com/bmjpodcasts/tuning-up-rehabilitation-after?in=bmjpodcasts/sets/bjsm-1   Contact Information Facebook: @Kate.Wason Twitter: @fitnerdkate Instagram: @fit.nerd.kate     For questions and feedback regarding this episode/request a topic please email us at brandonpoen@gmail.com    InMotion Physical Therapy Company Website InMotion East End Facebook Page InMotion Facebook Page   Clinic Information East End Clinic Address: 5711 S Laburnum Ave, Richmond, VA 23231 Phone: (804) 447-5355   West End Clinic Address: 3001 Hungary Spring Rd Suite d, Richmond, VA 23228 Phone: (804) 756-8490

Today we have a very special guest interviewer, Dr Yasmin Whately. She will be joining us from time to time on Deep Breaths to have in-depth chats with consultant anaesthetists about how they approach various procedures in different settings. Today, she discusses all things clot retrieval for acute ischaemic stroke with her guest Dr Wendy Morris. If you have any questions, comments or suggestions for future episodes, be sure to write to us at deepbreathspod@gmail.com. Thanks for listening, and happy studying. References for this episode include: https://journals.lww.com/anesthesia-analgesia/Fulltext/2019/04000/Anesthetic_Management_of_Emergency_Endovascular.15.aspx https://journals.lww.com/anesthesia-analgesia/Fulltext/2019/04000/Anesthetic_Management_of_Emergency_Endovascular.16.aspx https://www.ahajournals.org/doi/10.1161/STROKEAHA.113.003412?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed& 

In this episode, Michael explores the topic of Virtue Ethics. A philosophy traced back to Aristotle, Virtue Ethics is concerned with the formation of virtuous individuals based on ideal character traits. The life and work of Dr. Edmund Pellegrino, the father of bioethics and a famed proponent of this philosophy, is also discussed. What can Aristotle and Pellegrino teach us about being a good doctor, and what do they have to say about physician autonomy? Relevant Articles and Links: Edmund D. Pellegrino, Patient and Physician Autonomy: Conflicting Rights and Obligations in the Physician-Patient Relationship, 10 J. Contemp. Health L. & Pol'y 47 (1994). Pellegrino ED. Educating The Humanist Physician: An Ancient Ideal Reconsidered. JAMA. 1974;227(11):1288–1294. doi:10.1001/jama.1974.03230240046024 Stahl RY, Emanuel EJ. Physicians, Not Conscripts - Conscientious Objection in Health Care. N Engl J Med. 2017 Apr 6;376(14):1380-1385. doi: 10.1056/NEJMsb1612472. PMID: 28379789. Responses to Stahl & Emanuel: https://www.nejm.org/doi/10.1056/NEJMc1706233?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed https://www.georgetown.edu/news/bioethics-founder-georgetown-professor-pellegrino-passes-away/ https://plato.stanford.edu/entries/ethics-virtue/

Today on @MedTwitThisWeek, Dr. Shruti Patel (@ShrutiPatelMD) discusses her reaction to a (now retracted) @JAHA_AHA article that purports that “Diversity Doesn't Save Lives”. #MedTTW Published August 7, 2020 Host: Chris "The Chiu Man" Chiu Guest: Shruti Patel @ShrutiPatelMD's tweet that was discussed today: https://twitter.com/ShrutiPatelMD/status/1290081849935454215?s=20 Here's a link to the now retracted article from @JAHA_AHA: https://www.ahajournals.org/doi/full/10.1161/JAHA.120.015959?url_ver=Z39.88-2003 And here is the retraction notice: https://twitter.com/jaha_aha/status/1291429474429542400?s=21 If you aren't already, follow @londyloo's unyielding and important activism: https://twitter.com/londyloo?s=21 @evebowers_'s tweet about test scores and medical schools: https://twitter.com/evebowers_/status/1290753806658134019 @iwashyna's #NoManels pledge and email: https://twitter.com/iwashyna/status/1290645530977153027 @MedCrisis's philosophical YouTube video: https://twitter.com/MedCrisis/status/1290021491979870208?s=20 The wonderful @katepaint42's recent feature in @BBCNews https://twitter.com/thecurbsiders/status/1288831994235965440?s=20 Recent examples of her work here: https://twitter.com/katepaint42/status/1288620557228023814?s=20 And here: https://twitter.com/katepaint42/status/1288231907784876042?s=20 Looking for #MedTTW on other platforms? YouTube: https://www.youtube.com/channel/UCzqsMnQAkVCTd0I5DuUzTfA Facebook: https://www.facebook.com/MedTwitThisWeek/ Twitter: https://twitter.com/MedTwitThisWeek Podcast Links: https://anchor.fm/MedTTW Apple Podcast: https://podcasts.apple.com/us/podcast/med-twitter-this-week/id1516685985?uo=4

Episode #5 Management of Type 2 Diabetes Join Dr. Grady and Garrett, both Type 1 Diabetics, as they talk about blood sugar, overall health, and how to take control of your health to gain the freedom to live the life you deserve. In this episode, Dr. Donohoe and Garrett discuss the management of Type 2 Diabetes and the mechanisms of how diet and exercise are such powerful tools when trying to achieve optimal blood glucose levels. We also get into sleep and stress management in regards to blood sugar. PLEASE SUBSCRIBE TO THE PODCAST For more Diabuddies content follow us on The Diabuddies Podcast Facebook page. Twitter: @TheDiabuddies Instagram: @thediabuddiespodcast You can email us at TheDiabuddiesPodcast@gmail.com   Resources/Links Discussed in the episode: Richter, E.A., & Hargreaves, M., (2013). Exercise, GLUT4, and Skeletal Muscle Glucose Uptake. Physiological Reviews; 93(3):993-1017. https://www.physiology.org/doi/full/10.1152/physrev.00038.2012?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed Niu, Y., et al., (2017). Exercise-induced GLUT4 transcription via inactivation of HDAC4/5 in mouse skeletal muscle in an AMPKα2-dependent manner. BBA Molecular Basis of Disease; 1863(9):2372-2381 https://www.sciencedirect.com/science/article/pii/S092544391730220X?via%3Dihub Yin, J., Xing, H., & Ye, J., (2008). Efficacy of Berberine in Patients with Type 2 Diabetes. Metabolism; 57(5): 712-717. https://www.ncbi.nlm.nih.gov/pubmed/18442638 Wang, H., Zhu, C., Ying, Y., Luo, L., Huang, D., & Luo, Z., (2018). Metformin and berberine, two versatile drugs in the treatment of common metabolic diseases. Oncotarget; 9(11): 10135-10146. https://www.ncbi.nlm.nih.gov/pubmed/29515798 De Souza, JFT., Dattilo, M., de Mello, MT., Tuflk, S.,&  Antunes, HKM (2017). High-Intensity Interval Training Attenuates Insulin Resistance Induced by Sleep Deprivation in Healthy Males. Front Physiol; 8: 992. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725446/ Ahmed, A. Bakrudeen Ali, et al. “In Vitro Callus and in Vivo Leaf Extract of Gymnema Sylvestre Stimulate β-Cells Regeneration and Anti-Diabetic Activity in Wistar Rats.” Phytomedicine, vol. 17, no. 13, 2010, pp. 1033–1039., doi:10.1016/j.phymed.2010.03.019. Al‐Romaiyan, Altaf, et al. “A Novel            Gymnema Sylvestre Extract Protects Pancreatic Beta‐Cells from Cytokine‐Induced Apoptosis.” Phytotherapy Research, 2019, doi:10.1002/ptr.6512. Kuo, Daih-Huang, et al. “Body Weight Management Effect of Burdock (Arctium Lappa L.) Root Is Associated with the Activation of AMP-Activated Protein Kinase in Human HepG2 Cells.” Food Chemistry, vol. 134, no. 3, 2012, pp. 1320–1326., doi:10.1016/j.foodchem.2012.03.023. Lan, Jiarong, et al. “Meta-Analysis of the Effect and Safety of Berberine in the Treatment of Type 2 Diabetes Mellitus, Hyperlipemia and Hypertension.” Journal of Ethnopharmacology, vol. 161, 2015, pp. 69–81., doi:10.1016/j.jep.2014.09.049. Lee, Woo Je. “α-Lipoic Acid Increases Insulin Sensitivity by Activating AMPK in Skeletal Muscle.” Biochemical and Biophysical Research Communications, vol. 332, no. 3, 2005, pp. 885–891., doi:10.1016/j.bbrc.2005.05.035. Magistrelli, Ashley, and Jo Carol Chezem. “Effect of Ground Cinnamon on Postprandial Blood Glucose Concentration in Normal-Weight and Obese Adults.” Journal of the Academy of Nutrition and Dietetics, vol. 112, no. 11, 2012, pp. 1806–1809., doi:10.1016/j.jand.2012.07.037. Viollet, Benoit. “Targeting the AMPK Pathway for the Treatment of Type 2 Diabetes.” Frontiers in Bioscience, Volume, no. 14, 2009, p. 3380., doi:10.2741/3460. Wei, Wei, et al. “A Clinical Study on the Short-Term Effect of Berberine in Comparison to Metformin on the Metabolic Characteristics of Women with Polycystic Ovary Syndrome.” European Journal of Endocrinology, vol. 166, no. 1, 2012, pp. 99–105., doi:10.1530/eje-11-0616.

Many thanks to Chris LeMond, TheHarmonicPulse, SAMUCA CHIODINI, Jim Haugland, Denis, bj7xtas1, thebudsofmay, Zippy Leroux, user name, Yhoda, Joe Turgeon and Daniel Proctor for your insightful questions! :14 What's the deal with Fanned Frets? Also, how does an understand of physics relate to music? 2:23 Is Synesthesia real, or just some BS you made up? 5:11 What is the function of the Fm7 in the chorus to Sir Duke by Stevie Wonder? 8:08 How do you come up with melodies? 10:06 How do you keep so relaxed with your technique on bass? 12:02 What are your thoughts on NOT recording to a click in a modern DAW environment? 14:01 On modern jazz big band music 14:09 How do you approach memorizing large amounts of music? 15:01 Can Adam submit a song for US to review? 15:11 HOW MUCH DID THE 440 CONSPIRACY PAY YOU TO MAKE THE ANTI-432 VIDEO?!?! 15:48 Can I get away with not doubling if I'm a woodwind player looking to make a career in NYC? 17:21 How do I start a career in TEACHING music?   SYNESTHESIA RESEARCH (Cognitive Neuroscience) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4037840/ (Journal of Cognitive Neuroscience) http://www.mitpressjournals.org/doi/abs/10.1162/jocn.2010.21486?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed& http://cogprints.org/6268/1/Cortex_sound-colour_Synaesthesia.pdf (Yale journal of biology and medicine) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670440/ (Biological Psychiatry) http://www.biologicalpsychiatryjournal.com/article/S0006-3223(99)00056-6/fulltext (Neuropsychologia) http://www.sciencedirect.com/science/article/pii/S0028393212003879?via%3Dihub (Consciousness and Cognition) http://www.sciencedirect.com/science/article/pii/S1053810013000834 (Neuron) http://www.cell.com/neuron/fulltext/S0896-6273(05)00835-4 Psychology of Music http://mobile.www.daysyn.com/Rogers1987.pdf American Journal of Psychology https://www.jstor.org/stable/1410812?seq=1#page_scan_tab_contents (Others) http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0134456 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126805/ https://www.ncbi.nlm.nih.gov/pubmed/23000109 SUPPORT ME ON PATREON 
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