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Toe sucking, Amelia Earhart and Target is the new Bud Light. What are the angriest airports in the country and Australia is the world's Florida.
On today's show…A Texas A&M professor flunks all his students, preventing some from getting their diplomas, after ChatGPT falsely claimed it wrote their papers 29:25. RIP to Vice News and the return of the rise of the fat man 38:06. Used condoms allegedly mailed to dozens of Melbourne women in ‘targeted attack' 01:00:51. 00:00 Intro 01:48 Hit us on the socials! 02:50 The struggles of life… ☕ Cup of Coffee in the Big Time ☕ 03:47 What is your favorite Fast and Furious movie? 07:44 Ecuador's President Lasso dissolves Congress amid impeachment proceedings 13:07 ‘Shaken' Meghan Markle, Prince Harry involved in ‘near-fatal' paparazzi chase in NYC 17:25 IT worker sued boss who marked problems with ‘XX' as she thought they were kisses 24:39 Taco Bell is fighting to cancel the ‘Taco Tuesday' trademark
Chris and Sam sat down with Ben Ashworth to discuss athletic shoulder strength testing. Ben is a physio, coach, high performance consultant, and PhD candidate specializing in shoulder rehabilitation, monitoring, and performance. We dive into: the conception of the ASH test, differentiating short versus long lever testing, reliable testing setups, rate of force vs peak force, specific numbers and percentages to use as rough standards, frameworks for return to practice and sport, and much more. More about Ben: Athletic Shoulder Instagram Athletic Shoulder Website Ben's Twitter Ben's Online Course: Athletic Shoulder Level 1 Papers discussed and references: Force Awakens The ASH Test ASH References ASH Test Protocol --- More about us: YouTube: https://www.youtube.com/e3rehab Website: https://e3rehab.com/ Instagram: https://www.instagram.com/e3rehab/ Twitter: https://twitter.com/E3Rehab --- Sponsors: Minimalist Footwear: https://www.vivobarefoot.com/ (Discount code: E315 for 15% off) VALD: www.vald.com --- @dr.samspinelli @dr.surdykapt @tony.comella @chrishughen --- This episode was produced by Matt Hunter.
Tough week for the GOP. We try to go easy but… Also, Bobby De Niro has a future orphan at 79, a FLA man has quite a night out, and ChatGPT is picking stocks better than the experts.
La Florida vive un éxodo de inmigrantes sin precedentes, trabajadores informales bsucan chamba en otros estados ya que en la Florida todo se puso difícil.
Hayley teaches the history of a system near and dear to her heart: the lottery. You may only have a one in 14 million chance of picking the winning numbers, but you have a one in one chance of enjoying this episode- bu-dum-tss! Then, Kat and Sir Arthur Conan Doyle prove to everyone that fairies are real and men are stupid. Two country girls got more than they bargained for when they presented their parents with photographs of fairies. Lottery Clip: https://www.youtube.com/watch?v=OhC5NmFouHU https://linktr.ee/NightClassy Lottery Sources Statistics at UC Berkeley | Department of Statistics Statistics at UC Berkeley | Department of Statistics https://www.stat.berkeley.edu/~aldous/157/Papers/kaplan.pdf Lottery https://en.wikipedia.org/wiki/Lottery It turns out money can kind of buy happiness after all Piper https://www.vox.com/future-perfect/2019/9/2 Lottery fraud https://en.wikipedia.org/wiki/Lottery_fraud Winning the Mega Millions jackpot sounds great, but this story is tragic Riley https://www.courier-journal.com/story/news/local/2017/08/23/kentucky-lottery-winner-died-penniless/594716001/ Everything You Know About the Fate of Lottery Winners Is Probably Wrong Martinez https://time.com/5427275/lottery-winning-happiness-debunked/ Why You Can't Buy Lottery Tickets With a Credit Card Lee https://moneyinc.com/cant-buy-lottery-tickets-credit-card/ A look back at the PA Lottery scandal https://youtu.be/OhC5NmFouHU 9 Smart Moves for Lottery Winners Hanscom Federal Credit Union https://go.hfcu.org/blog/lottery Cottingley Fairies Sources: https://www.theguardian.com/artanddesign/2019/mar/31/cottingley-fairies-fake-photos-go-under-the-hammer https://blog.newspapers.com/arthur-conan-doyle-and-the-cottingley-fairies/ https://en.wikipedia.org/wiki/Cottingley_Fairies https://en.wikipedia.org/wiki/Theosophical_Society https://www.bbc.com/news/uk-england-leeds-55187973 http://hoaxes.org/photo_database/image/the_cottingley_fairies/ Produced by Parasaur Studios © 2023
Podcast Home.https://thebibleproject.buzzsprout.comHelp me to continue to make and share great Biblical content everyday and download my latest free Book at | PatreonYou can also support my podcast athttps://www.buymeacoffee.com/JRMcCandlessBibliography (Complete Book)i Dr Samuel Johnson (Rambler Texts Vol 2) 1750ii Absolute Morality Survey Banu Research 2001 (Revised 2011) Banuresearch.orgiii E Kant, Critique of Practical Reason – Introduction (1788) (christianclassicsetheriallibrary.org.)iv A. R. Damasio, How the brain creates the mind, (Scientific American Publishing 1999) P74-79 v Bertrand Russell, Introduction from Why I am not a Christian. at www.drew.edu.net viDavid Hume, The letters of David Hume, Vol 1 Ed J Y T Greig (Oxford Clarendon, 1932), P187. vii Augustine, Against the Epistle of Manichaeus, Chapter 1 (c397AD available on Wikipedia Commons). viiiCited in Erickson, Introducing Christian Doctrine, P138-139.ix Genesis Ch1: Vs31xJ.B. Phillips – Cited by Little – Know what you believe, P81.xiC. S. Lewis, The Abolition of Man (New York: Macmillan, 1947), P69.xii John Milton, Paradise Lost (Book I) Line 255xiiiC.S. Lewis “The problem of pain”. 1962 Fontana Edition P29xiv Mary Baker Eddy, Miscellaneous Writings (Christian Science Publishing Society, 1986) P27 xvEmily Cady, Lessons in truth (Kansas City, Unity School of Christianity, 1941) P35 xvi Emily Cay, Lessons in truth (Kansas City, Unity School of Christianity, 1941) P 35 xvii Matthew Chapter 6 Verse 13. xviii Shirley McClean, (It's all in the playing) Cited in the Critique Book Review Magazine by Douglas Groothuis P28 xix Gary Zukav, The Seat of the Soul (New York; Simon and Schuster, 1989) P4xx Athanasian Creed (Line 43) xxi Sigmund Freud, The Future of an Illusion (Hogart Press London 1927) xxiiC.S.Lewis, The problem of Pain (4th Edition (Fontana Books 1946) P120 xxiii Norman L Geisler, Baker Encyclopaedia of Christian Apologetics. (Grand Rapids 1999) P220xxiv Psalm 119 xxv Roman Chapter13: Verses 1-7 xxviProverbs Chapter 22:15 to 23:13xxvii Sinners in the Hands of an Angry God, Jonathan Edwards (Enfield Connecticut) July 8, 1741 xxviii Dietrich Bonhoeffer, Letter and Papers.xxix George Santayana (1905) Reason in Common Sense, volume 1 of The Life of Reason. xxx Josephus Antiquities' of the Jews Ch 8.63-64 c AD 37-100xxxi G W F Hegel, Lectures on the Philosophy of History. (Published Posthumously in 1837) xxxii K Marx, A Contribution to the Critique of Political Economy, 1859 xxxiii Kevin Hanhoover, This we believe, Grand Rapids Zondervan 2000. P64xxxiv Gary Habermas, The Historical Jesus, College Press Publishing Company 1996 Cited in Introduction. xxxv C.S. Lewis, Mere Christianity. Fontana 1962 Fifth Edition. P 102.xxxvi CS Lewis “The Abolition of Man”. www.columbia.edu/cu/augustine/archSupport the showFurther Discipleship Training Courses Free at;linkedin.com/in/jeremy-mccandless-68353b16Podcast Archive also athttps://www.youtube.com/c/JeremyRMcCandlessThe LIFE Podcast - The Bible Project | FacebookMy Amazon Author Pageamazon.com/author/jeremymccandlessJeremy McCandless is creating podcasts and devotional resources | PatreonHelp us continue making great content for listeners everywhere.https://thebibleproject.buzzsprout.com
Presneted by Fiona Kelly.
Podcast Home.https://thebibleproject.buzzsprout.comHelp me to continue to make and share great Biblical content everyday and download my latest free Book at | PatreonYou can also support my podcast athttps://www.buymeacoffee.com/JRMcCandlessBibliography (Complete Book)i Dr Samuel Johnson (Rambler Texts Vol 2) 1750ii Absolute Morality Survey Banu Research 2001 (Revised 2011) Banuresearch.orgiii E Kant, Critique of Practical Reason – Introduction (1788) (christianclassicsetheriallibrary.org.)iv A. R. Damasio, How the brain creates the mind, (Scientific American Publishing 1999) P74-79 v Bertrand Russell, Introduction from Why I am not a Christian. at www.drew.edu.net viDavid Hume, The letters of David Hume, Vol 1 Ed J Y T Greig (Oxford Clarendon, 1932), P187. vii Augustine, Against the Epistle of Manichaeus, Chapter 1 (c397AD available on Wikipedia Commons). viiiCited in Erickson, Introducing Christian Doctrine, P138-139.ix Genesis Ch1: Vs31xJ.B. Phillips – Cited by Little – Know what you believe, P81.xiC. S. Lewis, The Abolition of Man (New York: Macmillan, 1947), P69.xii John Milton, Paradise Lost (Book I) Line 255xiiiC.S. Lewis “The problem of pain”. 1962 Fontana Edition P29xiv Mary Baker Eddy, Miscellaneous Writings (Christian Science Publishing Society, 1986) P27 xvEmily Cady, Lessons in truth (Kansas City, Unity School of Christianity, 1941) P35 xvi Emily Cay, Lessons in truth (Kansas City, Unity School of Christianity, 1941) P 35 xvii Matthew Chapter 6 Verse 13. xviii Shirley McClean, (It's all in the playing) Cited in the Critique Book Review Magazine by Douglas Groothuis P28 xix Gary Zukav, The Seat of the Soul (New York; Simon and Schuster, 1989) P4xx Athanasian Creed (Line 43) xxi Sigmund Freud, The Future of an Illusion (Hogart Press London 1927) xxiiC.S.Lewis, The problem of Pain (4th Edition (Fontana Books 1946) P120 xxiii Norman L Geisler, Baker Encyclopaedia of Christian Apologetics. (Grand Rapids 1999) P220xxiv Psalm 119 xxv Roman Chapter13: Verses 1-7 xxviProverbs Chapter 22:15 to 23:13xxvii Sinners in the Hands of an Angry God, Jonathan Edwards (Enfield Connecticut) July 8, 1741 xxviii Dietrich Bonhoeffer, Letter and Papers.xxix George Santayana (1905) Reason in Common Sense, volume 1 of The Life of Reason. xxx Josephus Antiquities' of the Jews Ch 8.63-64 c AD 37-100xxxi G W F Hegel, Lectures on the Philosophy of History. (Published Posthumously in 1837) xxxii K Marx, A Contribution to the Critique of Political Economy, 1859 xxxiii Kevin Hanhoover, This we believe, Grand Rapids Zondervan 2000. P64xxxiv Gary Habermas, The Historical Jesus, College Press Publishing Company 1996 Cited in Introduction. xxxv C.S. Lewis, Mere Christianity. Fontana 1962 Fifth Edition. P 102.xxxvi CS Lewis “The Abolition of Man”. www.columbia.edu/cu/augustine/arch/lewis/abolition1.htm#1xxxvii George Will, www.azquotes.com/author/15665-George_WiFurther Discipleship Training Courses Free at;linkedin.com/in/jeremy-mccandless-68353b16Podcast Archive also athttps://www.youtube.com/c/JeremyRMcCandlessThe LIFE Podcast - The Bible Project | FacebookMy Amazon Author Pageamazon.com/author/jeremymccandlessJeremy McCandless is creating podcasts and devotional resources | PatreonHelp us continue making great content for listeners everywhere.https://thebibleproject.buzzsprout.com
Presented by Fiona Kelly.
Podcast Home.https://thebibleproject.buzzsprout.comHelp me to continue to make and share great Biblical content everyday and download my latest free Book at | PatreonYou can also support my podcast athttps://www.buymeacoffee.com/JRMcCandlessBibliography (Complete Book).i Dr Samuel Johnson (Rambler Texts Vol 2) 1750ii Absolute Morality Survey Banu Research 2001 (Revised 2011) Banuresearch.orgiii E Kant, Critique of Practical Reason – Introduction (1788) (christianclassicsetheriallibrary.org.)iv A. R. Damasio, How the brain creates the mind, (Scientific American Publishing 1999) P74-79 v Bertrand Russell, Introduction from Why I am not a Christian. at www.drew.edu.net viDavid Hume, The letters of David Hume, Vol 1 Ed J Y T Greig (Oxford Clarendon, 1932), P187. vii Augustine, Against the Epistle of Manichaeus, Chapter 1 (c397AD available on Wikipedia Commons). viiiCited in Erickson, Introducing Christian Doctrine, P138-139.ix Genesis Ch1: Vs31xJ.B. Phillips – Cited by Little – Know what you believe, P81.xiC. S. Lewis, The Abolition of Man (New York: Macmillan, 1947), P69.xii John Milton, Paradise Lost (Book I) Line 255xiiiC.S. Lewis “The problem of pain”. 1962 Fontana Edition P29xiv Mary Baker Eddy, Miscellaneous Writings (Christian Science Publishing Society, 1986) P27 xvEmily Cady, Lessons in truth (Kansas City, Unity School of Christianity, 1941) P35 xvi Emily Cay, Lessons in truth (Kansas City, Unity School of Christianity, 1941) P 35 xvii Matthew Chapter 6 Verse 13. xviii Shirley McClean, (It's all in the playing) Cited in the Critique Book Review Magazine by Douglas Groothuis P28 xix Gary Zukav, The Seat of the Soul (New York; Simon and Schuster, 1989) P4xx Athanasian Creed (Line 43) xxi Sigmund Freud, The Future of an Illusion (Hogart Press London 1927) xxiiC.S.Lewis, The problem of Pain (4th Edition (Fontana Books 1946) P120 xxiii Norman L Geisler, Baker Encyclopaedia of Christian Apologetics. (Grand Rapids 1999) P220xxiv Psalm 119 xxv Roman Chapter13: Verses 1-7 xxviProverbs Chapter 22:15 to 23:13xxvii Sinners in the Hands of an Angry God, Jonathan Edwards (Enfield Connecticut) July 8, 1741 xxviii Dietrich Bonhoeffer, Letter and Papers.xxix George Santayana (1905) Reason in Common Sense, volume 1 of The Life of Reason. xxx Josephus Antiquities' of the Jews Ch 8.63-64 c AD 37-100xxxi G W F Hegel, Lectures on the Philosophy of History. (Published Posthumously in 1837) xxxii K Marx, A Contribution to the Critique of Political Economy, 1859 xxxiii Kevin Hanhoover, This we believe, Grand Rapids Zondervan 2000. P64xxxiv Gary Habermas, The Historical Jesus, College Press Publishing Company 1996 Cited in Introduction. xxxv C.S. Lewis, Mere Christianity. Fontana 1962 Fifth Edition. P 102.xxxvi CS Lewis “The Abolition of Man”. www.columbia.edu/cu/augustine/arch/lewis/abolition1.htm#1xxxvii George Will, www.azquotes.com/author/15665-George_WFurther Discipleship Training Courses Free at;linkedin.com/in/jeremy-mccandless-68353b16Podcast Archive also athttps://www.youtube.com/c/JeremyRMcCandlessThe LIFE Podcast - The Bible Project | FacebookMy Amazon Author Pageamazon.com/author/jeremymccandlessJeremy McCandless is creating podcasts and devotional resources | PatreonHelp us continue making great content for listeners everywhere.https://thebibleproject.buzzsprout.com
The NPDA has recently come out with two of many position papers that intend to bridge a gap between dealers and OEM's. Listen in to understand their point of view.
Does your desk or office look like a paper recycling facility? Stacks of paper here, piles there? That disorder may prevent you from managing money wisely. We'll tell you how to do some financial spring cleaning on this Faith and Finance.John Wesley is credited with the idea, “Earn all you can, save all you can, and give all you can.” It's harder to do that if your financial papers are disorganized.START ORGANIZINGYou can start getting things organized by taking all of your stacks and piles of paper and putting them into three categories: Those you don't need to keep, those you want to keep for seven years, and those you need to keep forever.Category 1: Papers you don't need to keep, go into the shredder. If you don't have one, buy one that makes crosscuts. It's worth the small expense to prevent identity thieves from sifting through your garbage.Category 2: Papers you want to keep for seven years, will usually be anything related to taxes. Make folders for those and keep them in a file cabinet, another worthwhile expense if you don't have one.Category 3: Papers you need to keep forever, would include marriage and birth certificates, passports, deeds and other documents related to property ownership. Keep those in a fireproof safe or safe deposit box.Now that your papers are in order, you can tackle some of the other items on your financial spring cleaning list.Do you have 3 to 6 months of living expenses in your emergency fund to cover an unexpected job loss, medical condition, or some other financial calamity? If not, spring is a great time to start or increase your emergency savings.You want to keep those funds in an online bank to get the best interest rate, and you can automate the process by having a certain amount taken from each paycheck and put directly into savings. Check your bank's website for details about automating your savings. That money won't show up in your checking account balance, and you know what they say— out of sight, out of mind.TAXESNow, tax season just ended, so it's a great time to think about your withholdings. If you have too little withheld, you could get hit with a penalty. On the other hand, a big refund means you're just giving Uncle Sam an interest-free loan with money you can put to better use throughout the year.So, how close did the amount you had withheld for taxes match what you owed? If you owed more than around $500, or you're expecting a refund of that much or more, you need to fill out a new W-4 form to adjust your withholdings.This is especially important if you had any major life changes, such as more income or maybe a new addition to the family. You can get a new W-4 from your employer or download one from IRS.gov.ESTATE PLANNINGAnd speaking of family members, you should also take a few minutes to look over the beneficiary designations for retirement and other financial accounts. If you haven't made any, now is the time to do it. A beneficiary designation will allow those assets to go directly to the person or persons you name, without having to go through probate.INSURANCEYour next financial spring cleaning task is to pull out all of your insurance policies, for life, health, home, auto, and anything else. Are they meeting your needs? You'll have to wait until open season to change health insurance, but others can be changed or replaced at any time.For example, are you driving less this year because you're working from home more? Alert your auto insurance agent of that change, because it could well lower your premiums.If you made major purchases or changes to your home, you'll want to make sure your homeowners policy covers them. It's a good idea to take pictures from different angles in every room of your house. That way you can show an insurance adjuster exactly what you lost in case of theft or fire.For life insurance, check to see if your policy provides a death benefit of at least 10 to 12 times your annual salary. If not, increase it accordingly. And by the way, you want the least expensive term insurance policy. Whole life policies mix insurance with investing, and you'll always be better off by doing your investing separately.SUBSCRIPTIONSOkay, one more item on your list— check your subscriptions and streaming services to see what you might be able to cancel.You can actually download apps that will review all of your automatic bank debits for apps and show you ones you no longer need. For streaming apps, if you're not watching them, cancel ‘em. It can save you a ton of money.Well, that's your financial spring cleaning list. We hope you'll get started ticking off items today.On this program, Rob also answers listener questions: Will you owe capital gains tax on the sale of a property? When does an annuity make sense in retirement? Do identity theft security subscriptions like “Lifelock” make sense? Would it make sense to take a loan against your retirement funds to buy a tractor? RESOURCES MENTIONED:FTC.govIdentityTheft.govExperianTransUnionEquifaxRemember, you can call in to ask your questions most days at (800) 525-7000. Also, visit our website at FaithFi.com where you can join the FaithFi Community, and give as we expand our outreach.
Hour 2: Evan's accusations of the Rays has made the Post, but Craig is the one catching the insults. And we live in a hot take world, but there have been a few lately that are a bit too much.
Dan talking about The Petroleum Papers by Geoff Dembicki.
Presented by Fiona Kelly.
Presented by Fiona Kelly.
Podcast Home.https://thebibleproject.buzzsprout.comHelp me to continue to make and share great Biblical content everyday and download my latest free Book at | PatreonYou can also support my podcast athttps://www.buymeacoffee.com/JRMcCandlessBibliography (Complete Book).i Dr Samuel Johnson (Rambler Texts Vol 2) 1750ii Absolute Morality Survey Banu Research 2001 (Revised 2011) Banuresearch.orgiii E Kant, Critique of Practical Reason – Introduction (1788) (christianclassicsetheriallibrary.org.)iv A. R. Damasio, How the brain creates the mind, (Scientific American Publishing 1999) P74-79 v Bertrand Russell, Introduction from Why I am not a Christian. at www.drew.edu.net viDavid Hume, The letters of David Hume, Vol 1 Ed J Y T Greig (Oxford Clarendon, 1932), P187. vii Augustine, Against the Epistle of Manichaeus, Chapter 1 (c397AD available on Wikipedia Commons). viiiCited in Erickson, Introducing Christian Doctrine, P138-139.ix Genesis Ch1: Vs31xJ.B. Phillips – Cited by Little – Know what you believe, P81.xiC. S. Lewis, The Abolition of Man (New York: Macmillan, 1947), P69.xii John Milton, Paradise Lost (Book I) Line 255xiiiC.S. Lewis “The problem of pain”. 1962 Fontana Edition P29xiv Mary Baker Eddy, Miscellaneous Writings (Christian Science Publishing Society, 1986) P27 xvEmily Cady, Lessons in truth (Kansas City, Unity School of Christianity, 1941) P35 xvi Emily Cay, Lessons in truth (Kansas City, Unity School of Christianity, 1941) P 35 xvii Matthew Chapter 6 Verse 13. xviii Shirley McClean, (It's all in the playing) Cited in the Critique Book Review Magazine by Douglas Groothuis P28 xix Gary Zukav, The Seat of the Soul (New York; Simon and Schuster, 1989) P4xx Athanasian Creed (Line 43) xxi Sigmund Freud, The Future of an Illusion (Hogart Press London 1927) xxiiC.S.Lewis, The problem of Pain (4th Edition (Fontana Books 1946) P120 xxiii Norman L Geisler, Baker Encyclopaedia of Christian Apologetics. (Grand Rapids 1999) P220xxiv Psalm 119 xxv Roman Chapter13: Verses 1-7 xxviProverbs Chapter 22:15 to 23:13xxvii Sinners in the Hands of an Angry God, Jonathan Edwards (Enfield Connecticut) July 8, 1741 xxviii Dietrich Bonhoeffer, Letter and Papers.xxix George Santayana (1905) Reason in Common Sense, volume 1 of The Life of Reason. xxx Josephus Antiquities' of the Jews Ch 8.63-64 c AD 37-100xxxi G W F Hegel, Lectures on the Philosophy of History. (Published Posthumously in 1837) xxxii K Marx, A Contribution to the Critique of Political Economy, 1859 xxxiii Kevin Hanhoover, This we believe, Grand Rapids Zondervan 2000. P64xxxiv Gary Habermas, The Historical Jesus, College Press Publishing Company 1996 Cited in Introduction. xxxv C.S. Lewis, Mere Christianity. Fontana 1962 Fifth Edition. P 102.xxxvi CS Lewis “The Abolition of Man”. www.columbia.edu/cu/augustine/arch/lewis/abolition1.htm#1xxxvii George Will, www.azquotes.com/author/15665-George_WFurther Discipleship Training Courses Free at;linkedin.com/in/jeremy-mccandless-68353b16Podcast Archive also athttps://www.youtube.com/c/JeremyRMcCandlessThe LIFE Podcast - The Bible Project | FacebookMy Amazon Author Pageamazon.com/author/jeremymccandlessJeremy McCandless is creating podcasts and devotional resources | PatreonHelp us continue making great content for listeners everywhere.https://thebibleproject.buzzsprout.com
Presented by Fiona Kelly.
Presented by Fiona Kelly.
A new research paper was published in Oncotarget's Volume 14 on May 4, 2023, entitled, “Human LY6 gene family: potential tumor-associated antigens and biomarkers of prognosis in uterine corpus endometrial carcinoma.” The human Lymphocyte antigen-6 (LY6) gene family has recently gained interest for its possible role in tumor progression. In this new study, researchers Luke A. Rathbun, Anthony M. Magliocco and Anil K. Bamezai from Villanova University carried out in silico analyses of all known LY6 gene expression and amplification in different cancers using TNMplot and cBioportal. In addition, the team analyzed patient survival by Kaplan-Meier plotter after mining the TCGA database. “We report that upregulated expression of many LY6 genes is associated with poor survival in uterine corpus endometrial carcinoma (UCEC) cancer patients.” Importantly, the expression of several LY6 genes is elevated in UCEC when compared to the expression in normal uterine tissue. For example, LY6K expression is 8.25× higher in UCEC compared to normal uterine tissue, and this high expression is associated with poor survival with a hazard ratio of 2.42 (p-value = 0.0032). Therefore, some LY6 gene products may serve as tumor-associated antigens in UCEC, biomarkers for UCEC detection, and possibly targets for directing UCEC patient therapy. “Further analysis of tumor-specific expression of LY6 gene family members and LY6-triggered signaling pathways is needed to uncover the function of LY6 proteins and their ability to endow tumor survival and poor prognosis in UCEC patients.” DOI - https://doi.org/10.18632/oncotarget.28409 Correspondence to - Anil K. Bamezai - anil.bamezai@villanova.edu Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28409 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - LY6 gene family, uterine cancer, tumor-associated antigen, patient survival, biomarker About Oncotarget Oncotarget is a primarily oncology-focused, peer-reviewed, open access journal. Papers are published continuously within yearly volumes in their final and complete form, and then quickly released to Pubmed. On September 15, 2022, Oncotarget was accepted again for indexing by MEDLINE. Oncotarget is now indexed by Medline/PubMed and PMC/PubMed. To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ Twitter - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957
We're on strike! Not as podcasters but as writers. Louisville has been letting 10-yr-olds work at McD's, but Utah won't let 24 yr-olds work in porn. The Navy has drag queens and Tucker Carlson has some rules about how white men should fight.
A new review paper was published in Oncotarget's Volume 14 on April 26, 2023, entitled, “Systemic AL amyloidosis: current approach and future direction.” In this review, researchers Maroun Bou Zerdan, Lewis Nasr, Farhan Khalid, Sabine Allam, Youssef Bouferraa, Saba Batool, Muhammad Tayyeb, Shubham Adroja, Mahinbanu Mammadii, Faiz Anwer, Shahzad Raza, and Chakra P. Chaulagain from SUNY Upstate Medical University, University of Texas MD Anderson Cancer Center, Monmouth Medical Center, University of Balamand, Cleveland Clinic Ohio, UnityPoint Methodist, Houston Methodist Cancer Center, and Cleveland Clinic Florida report the literature on the latest treatment updates of Systemic Light chain (AL) amyloidosis and the ongoing clinical trials highlighting the future treatments. “In this manuscript, we discuss the general approach towards treating patients with amyloidosis and dive into the future perspectives in this multi-systemic disease.” Systemic AL amyloidosis is a monoclonal plasma cell proliferative disorder characterized by deposition of amyloidogenic monoclonal light chain fragments causing organ dysfunction. It is a fatal disease and if not diagnosed and treated early can lead to organ failure and potentially death. The renal system along with the cardiovascular system are the most common organs involved, but other organs such as the gut and liver can be involved as well. The initial evaluation of patients requires confirming the diagnosis with tissue biopsy and staining with Congo red followed by confirmatory typing with mass spectrometry of the Congo red positive tissue. Then establishing the extent of the organs involvement by various staging and biomarkers testing. The treatment options and the tolerability of therapy depend on the disease staging, frailty and co-morbidities. The autologous hematopoietic cell transplantation (HCT) after high dose melphalan therapy is an effective strategy which is usually done after initial bortezomib induction therapy. Unfortunately, most systemic AL amyloidosis patients are not candidates for HCT due to frailty, old age, multi-organ involvement, and renal or heart failure at the time of diagnosis. While it is widely accepted that the patients need to be treated until they achieve complete hematologic response, the maintenance therapy after HCT is not well established in AL amyloidosis. “The relationship between AL amyloidosis and MGUS is less clear, but some studies suggest that the risk of developing AL amyloidosis may be increased in patients with MGUS. It is important for patients with these conditions to undergo regular monitoring and evaluation for signs of AL amyloidosis, as early diagnosis and treatment can improve outcomes.” DOI - https://doi.org/10.18632/oncotarget.28415 Correspondence to - Chakra P. Chaulagain - chaulac@ccf.org Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28415 Keywords - amyloidosis, management About Oncotarget Oncotarget is a primarily oncology-focused, peer-reviewed, open access journal. Papers are published continuously within yearly volumes in their final and complete form, and then quickly released to Pubmed. On September 15, 2022, Oncotarget was accepted again for indexing by MEDLINE. Oncotarget is now indexed by Medline/PubMed and PMC/PubMed. To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ Twitter - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957
Presented by John S. Doyle.
Presented by John S. Doyle.
Presented by John S. Doyle.
Epstein Island purchased for 60 million. Epstein investors being outed, WSJ article outing more billionaires, Samuel Pisar, Blinken's step father, is Maxwell's attorney, Pandora Papers name 330 politicians and officials, WMD shipped to Russia from NH, PV new reveal on pregnancy scam, King is related to Vlad, and more....
Presented by John S. Doyle.
A new research perspective was published in Oncotarget's Volume 14 on April 26, 2023, entitled, “Disruption of retinol-mediated IL-6 expression in colon cancer-associated fibroblasts: new perspectives on the role of vitamin A metabolism.” Colon cancer (CRC) is one of the most common malignancies and is a leading cause of cancer-related deaths worldwide. While the tumor microenvironment (TME) supports tumor growth and immune escape through tumor-promoting inflammation, the mechanisms by which the TME promotes CRC are far from being elucidated. Stromal myo-/fibroblasts (MFs) account for up to 30% of lamina propria cells in the normal human colon and their number is dramatically increased in CRC. Fibroblasts from cancers, also known as cancer-associated fibroblasts (CAFs), differ from normal colonic MF (N-MFs) and support tumor-promoting inflammation, in part due to increased IL-6 secretion. CAFs are very abundant in the TME and are among the major cells involved in tumor inflammation and progression. In this research perspective, researchers Romain Villéger, Marina Chulkina, Randy C. Mifflin, Don W. Powell, and Irina V. Pinchuk from the Université de Poitiers, Penn State Health Milton S. Hershey Medical Center and The University of Texas Medical Branch highlight recent data obtained regarding IL-6 regulation in colorectal cancer CAFs through vitamin A (retinol) metabolism, discuss current limitations in our understanding of the mechanisms leading to the CAF pro-inflammatory phenotype, and discuss potential approaches to target CAF retinoid metabolism during CRC treatment. "While the overall mechanisms responsible for the IL-6 increase within the CRC tumor stroma remain to be elucidated, our study highlights the crucial role of stromal vitamin A pathway in IL-6 regulation." DOI: https://doi.org/10.18632/oncotarget.28399 Correspondence to - Iryna V. Pinchuk - ipinchuk@pennstatehealth.psu.edu Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28399 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - tumor microenvironment, colon cancer, inflammation, fibroblasts, IL-6 About Oncotarget Oncotarget is a primarily oncology-focused, peer-reviewed, open access journal. Papers are published continuously within yearly volumes in their final and complete form, and then quickly released to Pubmed. On September 15, 2022, Oncotarget was accepted again for indexing by MEDLINE. Oncotarget is now indexed by Medline/PubMed and PMC/PubMed. To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ Twitter - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957
Presented by John S. Doyle.
Presented by John S. Doyle.
Presented by John S. Doyle.
A new research perspective was published in Oncotarget's Volume 14 on April 24, 2023, entitled, “Crossroads: the role of biomarkers in the management of lumps in the breast.” Here, Dr. Georg F. Weber from the University of Cincinnati Academic Health Center discusses a long-standing issue in women's health: lumps in the breast. Women over the age of 40 years often have lumps in their breasts that are not cancerous at the time of biopsy (comprising atypias, hyperplasias, papillomas, radial scars, lobular carcinoma in situ, ductal carcinoma in situ (DCIS)). These premalignant lesions in the breast pose a difficult decision-making problem, whether to treat proactively and accept the side effects or to engage in watchful waiting and possibly encounter a later diagnosis of invasive cancer. These patients need to make the difficult decision whether to treat the lesions proactively and accept the substantial compromise in their quality of life (from surgery, radiation, or hormone therapy: Surgery often ensues for definitive diagnosis. Radiation may follow the surgical resection of DCIS by lumpectomy. Hormone therapy can come into play as a strategy for risk reduction if the estimated 5-year risk exceeds 1.6% in the Gail model [2]) or to engage in watchful waiting and risk a later diagnosis of invasive cancer (the proverbial sword of Damocles). Currently, two forms of assessment are available to facilitate making that choice. Decades of cancer diagnosis and treatment have achieved substantial improvements. Yet, with every milestone of progress, new needs have surfaced. Breast care is privileged to have the availability of mammography and biopsy to assess the propensities of lumps. “A meaningful next step needs to entail biomarker development, pointing the way toward either preemptive treatment or watchful waiting at the crossroad.” DOI: https://doi.org/10.18632/oncotarget.28402 Correspondence to - Georg F. Weber - georg.weber@uc.edu Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28402 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - breast cancer premalignant lesion, biomarker, biopsy, mammography About Oncotarget Oncotarget is a primarily oncology-focused, peer-reviewed, open access journal. Papers are published continuously within yearly volumes in their final and complete form, and then quickly released to Pubmed. On September 15, 2022, Oncotarget was accepted again for indexing by MEDLINE. Oncotarget is now indexed by Medline/PubMed and PMC/PubMed. To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ Twitter - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957
Presented by John S. Doyle.
Stupid News Extra 5-2-2023 …Top Secret Papers found in the bathroom of a restaurant
Wall Street Journal has new papers showing meetings with Epstein that weren't on the flight log. Interesting stuff! Then we talked about Trump smearing DeSantis by counting C*vid Cases like a clueless clown. Secret Episode soon on http://Patreon.com/RareTalk My shop with new merch: http://DreamRare.com Telegram chat: https://T.Me/DreamRareChat Free Email List (Sign up!): https://StayInTouchWIthMe.com
This month we start off with a paper looking at the first pass success rate of intubation in cardiac arrest when performing continual CPR versus pausing. We then come on to two really interesting diagnostic papers and our prehospital accuracy for identifying certain injuries; we take a look at the accuracy of HEMS clinicians in assessing the stability of a pelvic ring and subsequent application of a pelvic binder. And then we look at the accuracy of prehospital clincians in assessing for all life and limb threatening injuries. Once again we'd love to hear any thoughts or feedback either on the website or via twitter @TheResusRoom. Simon & Rob
12 years ago today, Americans were given monumental news: Osama bin Laden, the terrorist leader of Al Qaeda responsible for planning the 9/11 attack, was killed by a U.S. Navy SEAL operation. New America senior fellow and jihadism expert Dr. Nelly Lahoud spent years translating bin Laden's personal letters and documents retrieved from his compound and has published a book all about her findings called "The Bin Laden Papers." She joins the podcast to share her discoveries, which include insight into the origins of the plot to hijack American planes, bin Laden's years in hiding, and the inner workings of his organization. Learn more about your ad choices. Visit megaphone.fm/adchoices
12 years ago today, Americans were given monumental news: Osama bin Laden, the terrorist leader of Al Qaeda responsible for planning the 9/11 attack, was killed by a U.S. Navy SEAL operation. New America senior fellow and jihadism expert Dr. Nelly Lahoud spent years translating bin Laden's personal letters and documents retrieved from his compound and has published a book all about her findings called "The Bin Laden Papers." She joins the podcast to share her discoveries, which include insight into the origins of the plot to hijack American planes, bin Laden's years in hiding, and the inner workings of his organization. Learn more about your ad choices. Visit megaphone.fm/adchoices
Presented by John S. Doyle.
Episode 4 of the DNA Papers features another chapter in the deep history of DNA in which the molecule itself doesn't come up. As in the previous episode, the paper makes no explicit reference to either the molecule or its function. But the paper occupies an indisputable role in the history of DNA, because the discovery it reports opened the door to discovery of the function of DNA as the carrier of hereditary information. Joining the discussion on “The significance of pneumococcal types” by the British microbiologist and epidemiologist Fred Griffith (The Journal of Hygiene 27 (02): 113–59; 1928) are: Lloyd Ackert, Drexel University Matthew Cobb, University of Manchester (guest moderator) Michel Morange, École Normale Supérieure For additional resources on this topic, see https://www.chstm.org/video/144.
UFOs in Vegas, kids in IL driving the school bus, and Mike talks about being at the final Corden taping. A passenger on a South African flight gets a little handsy and Mike has something to say about Philly. Follow Greg on Instagram @GregFitzsimmons Follow Mike on Instagram @GibbonsTime
In this episode of The Health Edge Mark and John review some papers that challenge the well accepted clinical meme that lowering LDL should be the focal point of reducing CV risk and all-cause mortality risk.Papers referenced:https://www.nature.com/articles/s4159...https://bmjopen.bmj.com/content/6/6/e...https://www.ncbi.nlm.nih.gov/pmc/arti...
Presented by Ronan Kelly
Presented by Ronan Kelly
Reginald Dwayne Betts and Titus Kaphar knew they were meant to work together when they first met. In 2019, they exhibited a project at MoMA PS1 that explored criminal justice through redacted court documents turned into poems and visual artworks. Now, that exhibit is a book called Redaction. They tell NPR's Juana Summers about how they both employ their mediums to capture the effects of incarceration, and how their collaboration focuses on joy and community even amidst deep suffering.
See if you can fill in the blank!
3CX is not the only victim in the recent supply chain attack. The PaperCut critical vulnerability is under active exploitation. The Bumblebee malware loader is buzzing around in the wild. A new unique malware toolkit called Decoy Dog. Our guest Theresa Lanowitz from AT&T Cybersecurity shares insights on Securing the Edge. And the alleged Discord Papers leaker shared earlier and more widely than previously known. For links to all of today's stories check out our CyberWire daily news briefing: https://thecyberwire.com/newsletters/daily-briefing/12/78 Selected reading. 3CX Hackers Also Compromised Critical Infrastructure Firms (Infosecurity Magazine) That 3CX supply chain attack keeps getting worse (Register) Energy sector orgs in US, Europe hit by same supply chain attack as 3CX (Record) Even more victims found in complex 3CX supply chain attack (CybersecurityConnect) X_Trader Supply Chain Attack Affects Critical Infrastructure Organizations in U.S. and Europe (Symantec Enterprise Blogs) URGENT | PaperCut MF/NG vulnerability bulletin (March 2023) (PaperCut) PaperCut CVE-2023-27350 Deep Dive and Indicators of Compromise (Horizon3.ai) Russian Hackers Suspected in Ongoing Exploitation of Unpatched PaperCut Servers (The Hacker News) CISA KEV Breakdown | April 21, 2023 (Nucleus Security) CISA Adds Three Known Exploited Vulnerabilities to Catalog (Cybersecurity and Infrastructure Security Agency CISA) CISA Adds 3 Actively Exploited Flaws to KEV Catalog, including Critical PaperCut Bug (The Hacker News) CISA adds printer bug, Chrome zero-day and ChatGPT issue to exploited vulnerabilities catalog (Record) Bumblebee Malware Distributed Via Trojanized Installer Downloads (Secureworks). Google ads push BumbleBee malware used by ransomware gangs (BleepingComputer) Bumblebee malware infects victims via fake Zoom, Cisco and ChatGPT software installers (Record) Decoy Dog malware toolkit found after analyzing 70 billion DNS queries (BleepingComputer) Analyzing DNS Traffic for Anomalous Domains and Threat Detection (Infoblox Blog) Airman Shared Sensitive Intelligence More Widely and for Longer Than Previously Known (New York Times) FBI leak investigators home in on members of private Discord server (Washington Post) From Discord to 4chan: The Improbable Journey of a US Intelligence Leak (bellingcat) Europe's Planes Keep Flying Despite Cyberattack (Wall Street Journal)
Greg is visited by the ghost of his father, a Bud Light drinker loses his shit, Gen Z is getting fired and Mexico's president said we're all on drugs. Follow Greg on Instagram @GregFitzsimmons Follow Mike on Instagram @GibbonsTime
An Iranian threat actor exploits N-day vulnerabilities. CSC exposes subdomain hijacking vulnerabilities. More on the Discord Papers. An update on Russia's NTC Vulkan. Joe Carrigan on the aftermath of a $98M online investment fraud. Our guest is Blake Sobczak from Synack , host of the podcast WE'RE IN! And threat actor nomenclature: a scorecard, and a Periodic Table no more. For links to all of today's stories check out our CyberWire daily news briefing: https://thecyberwire.com/newsletters/daily-briefing/12/74 Selected reading. Nation-state threat actor Mint Sandstorm refines tradecraft to attack high-value targets (Microsoft Security) An Iranian hacking group went on the offensive against U.S. targets, Microsoft says (Washington Post) New CSC Research Finds One in Five DNS Records are Susceptible to Subdomain Hijacking Due to Insufficient Cyber Hygiene | CSC (CSC) DOD Assessing Document Disclosures and Implementing Mitigation Measures (U.S. Department of Defense) After leak, Pentagon purges some users' access to classified programs, launches security review (Breaking Defense) Why Did a 21-Year-Old Guardsman Have Access to State Secrets? (Vice) U.S. officials have examined whether alleged doc leaker had foreign links (POLITICO) The Air Force Loves War Gamers Like Alleged Leaker Teixeira (Military.com) FBI Investigating Ex-Navy Noncommissioned Officer Linked to Pro-Russia Social-Media Account (Wall Street Journal) Pentagon leak suggests Russia honing disinformation drive – report (the Guardian) Dragos Analyzes Russian Programs Threatening Critical Civilian Infrastructure (Dragos) Microsoft shifts to a new threat actor naming taxonomy (Microsoft)