Podcasts about Mayo Clinic

Host: Darryl S. Chutka, M.D.  Guest: Benjamin Lai, M.D.  Substance use disorders are chronic and often relapsing conditions associated with compulsive substance use. They result from a complex interaction of chemistry within the brain, often combined with genetic and environmental issues. Common substances involve alcohol, stimulants, sedatives and opioids; opioids commonly prescribed by health care clinicians. Early identification of patients and care coordinated with behavioral health specialists is the best approach to improved patient outcomes. The topic for this podcast is “Addiction Care and Empowering Non-Specialists”, and my guest is Dr. Benjamin Lai, A Family Medicine physician from the Department of Family Medicine at the Mayo Clinic.  Connect with us! Mayo Clinic Talks Podcast Season 6 | Mayo Clinic School of Continuous Professional Development 

Menopause Management In Women with Cardiovascular Disease   Guest: Chrisandra Shufelt, M.D. Host: Marysia Tweet, M.D., M.S.   Listeners of this episode of “Interviews with the Experts” will gain a practical, evidence-based framework for managing menopausal symptoms in women with cardiovascular disease or elevated CVD risk. Through discussion of patient selection, menopause-specific cardiovascular risk factors, and the evolving data on hormone therapy. Listeners will leave better equipped to individualize care and counsel patients with confidence.   Topics Discussed: Treatment for menopause symptoms in women with risk factors for CVD  Appropriate candidates for hormone therapy Which cardiovascular risk factors are attributable to ovarian aging (menopause) versus chronological aging? What does the current evidence show regarding claims that menopausal hormone therapy prevents cardiovascular disease? How might the FDA's removal of the black box warning from menopausal hormone therapy labeling affect clinician prescribing practices and patient decision-making?   Connect with Mayo Clinic's Cardiovascular Continuing Medical Education online at https://cveducation.mayo.edu or on Twitter @MayoClinicCV and @MayoCVservices. LinkedIn: Mayo Clinic Cardiovascular Services Cardiovascular Education App: The Mayo Clinic Cardiovascular CME App is an innovative educational platform that features cardiology-focused continuing medical education wherever and whenever you need it. Use this app to access other free content and browse upcoming courses. Download it for free in Apple or Google stores today! No CME credit offered for this episode.   Podcast episode transcript found here.   Recorded on: 15-January-2026

"There are a lot of specifics that nurses need to keep in mind as they are administering this herpes simplex modified virus to patients because accidental exposure is of concern both to the patient, to their family members, as well as to healthcare workers. I always recommend nurses wear personal protective equipment, such as a gown, safety glasses, gloves, and/or a face shield," Heidi Finnes, PharmD, RPh, BCOP, director of clinical ambulatory practice at Mayo Clinic and assistant professor of pharmacy at Mayo Clinic Alix School of Medicine in Rochester, MN, told Jaime Weimer, MSN, RN, AGCNS-BS, AOCNS®, manager of oncology nursing practice at ONS, during a conversation about oncolytic viral therapy.  Music Credit: "Fireflies and Stardust" by Kevin MacLeod Licensed under Creative Commons by Attribution 3.0  Earn 0.5 contact hours of nursing continuing professional development (NCPD) by listening to the full recording and completing an evaluation at courses.ons.org by May 29, 2027. The planners and faculty for this episode have no relevant financial relationships with ineligible companies to disclose. ONS is accredited as a provider of nursing continuing professional development by the American Nurses Credentialing Center's Commission on Accreditation. Learning outcome: Learners will report an increase in knowledge about the use of oncolytic viruses to treat cancer. Episode Notes  Complete this evaluation for free NCPD.  ONS Podcast™ episodes: Pharmacology 101 series Episode 338: High-Volume Subcutaneous Injections: The Oncology Nurse's Role Episode 330: Stay Up to Date on Safe Handling of Hazardous Drugs Episode 273: Updates in Chemotherapy and Immunotherapy ONS Voice articles: Cutaneous Malignancies Have High Response to Oncolytic Virus Plus Immunotherapy Oncolytic Virus Kills Tumor Cells While Supporting T Cells What Nurses Need to Know About Talimogene Laherparepvec for Advanced Melanoma Clinical Journal of Oncology Nursing articles: Intralesional Therapy: Consensus Statements for Best Practices in Administration From the Melanoma Nursing Initiative Safe and Effective Standards of Care: Supporting the Administration of T-VEC for Patients With Advanced Melanoma in the Outpatient Oncology Setting Oncology Nursing Forum article: Administration and Handling of Talimogene Laherparepvec: An Intralesional Oncolytic Immunotherapy for Melanoma ONS book: Guide to Cancer Immunotherapy (second edition) ONS clinical practice resource: Safe Handling of Oncolytic Viruses ONS Huddle Card: Immunotherapy Association of Community Cancer Centers (ACCC) Drugs@FDA Hematology/Oncology Pharmacy Association (HOPA) Network for Collaborative Oncology Development and Advancement (NCODA) Patient Education Sheets To discuss the information in this episode with other oncology nurses, visit the ONS Communities.  To find resources for creating an ONS Podcast club in your chapter or nursing community, visit the ONS Podcast Library. To provide feedback or otherwise reach ONS about the podcast, email pubONSVoice@ons.org. Highlights From This Episode "[Oncolytic viruses] can have direct lysis to the tumor cells themselves, or they can cause immunogenic activation. They release tumor-associated antigens and then proinflammatory signals, so think of T cells, natural killer cells, those sorts of things, that can convert to immunologically cold tumors. Those are tumors that are immune silenced into hot tumors which are now immune activated. By doing that, they recruit those T cells and other cells to the area to attack both the primary tumors. But that's also thought to be how they work on distant or noninjected sites as well. This immunomodulatory capacity has led to the reclassification of oncolytic viruses as a form of cancer immunotherapy. So, think of it kind of similarly to how we think of immune checkpoint inhibitors in recruiting immune cells and leaving our immune system in the on position. This is also kind of a form of immunotherapy." TS 4:35 "One of the toxicities I know that is of significant concern to patients, family members, and healthcare workers is the incidence of herpes infections. Systemic herpetic infections are extremely rare and usually more common in patients who may be immunocompromised. In patients who also have other immune-related diseases—such as vitiligo, vasculitis, pneumonitis, sometimes worsening psoriasis—because you're mounting an immune response with these types of things, sometimes you can see a worsening of those types of immune symptoms. But for the most part, these types of side effects are very well tolerated in most patients." TS 9:07 "Talimogene is generally transmitted via bodily fluids or touch. It's not airborne. Herpes simplex virus isn't an airborne type of virus. Another thing to consider is where are you going to inject this? Are you going to do this in your infusion therapy unit? Are you going to do it in a dedicated room? Who's going to escort the patient to the room? How is the virus going to arrive at the room? How will you clean the room and all of the laboratory equipment or any of the exam tables that may be in there? I think having all of that discussed and assigned mitigates the consternation that can sometimes occur—the fear that occurs with administering a virus that is thought to be fairly communicable." TS 15:44 "Helping patients understand how this works [is important] because hearing that you're receiving a virus, particularly a herpes simplex virus, can be scary to a patient. I think understanding that it's modified or essentially we're taking the parts out of it so that we can directly inject a portion that recruits immune cells to that area, because the goal is for the oncolytic virus to attack cancer cells and then destroy them by triggering an immune response in the body." TS 20:51 "Sometimes patients are very concerned about urine in the toilet, bodily fluids, kissing loved ones, holding hands, hugging, you know, am I going to infect my loved one because I'm getting this type of an oncolytic virus therapy? I like to reassure patients that they can continue to hold hands and hug their loved ones as normal. Viral DNA is usually only present on the injection site. And as I mentioned previously, we want to cover that injection site with an occlusive dressing, at least with talimogene, for up to seven days. And particularly, if those injection sites are at all oozing or weeping, active virus is usually only on that injection site itself." TS 24:14

Our great friend Bill Morice, the Mayo Clinic Big Knocker, was in town for a meeting so he stopped by the studio for over an hour of great discussion on a wide-range of health care topics. See omnystudio.com/listener for privacy information.

Our great friend Bill Morice, the Mayo Clinic Big Knocker, was in town for a meeting so he stopped by the studio for over an hour of great discussion on a wide-range of health care topics. See omnystudio.com/listener for privacy information.

Photo courtesy Great Lakes Indian Fish and Wildlife Commission / Facebook All eleven federally recognized tribes in Wisconsin have seats on a new committee aimed at protecting wild rice. Chuck Quirmbach reports. Gov. Tony Evers (D-WI) has announced his 24 appointees to the Wild Rice Stewardship Council. One member, Gloria Waabigwan Wiggins (Bad River Band of Lake Superior Chippewa), works for the group Wisconsin Native Vote. Wiggins also keeps up a tribal tradition, protected by a 1983 federal court ruling, of gathering wild rice in the ceded territory of Northern Wisconsin. “I’ve been harvesting wild rice, manoomin, with my husband for say, the last 9-10 years. Our powwow, our celebration of manoomin, is in August. So that’s a very important event for our community.” Wiggins says wild rice is also part of a sacred migration story for the Anishinabe, Indigenous people of the Great Lakes region. But tribal and state officials report low production of wild rice in recent years, due to factors like windstorms and very heavy rainfall, and long-standing threats like water pollution and excessive waves from boats. Another member of the new Stewardship Council, Eric McLester, helps direct environmental policy for the Oneida Nation. He says the big picture concern is climate change. “The amount of rain, water levels. It’s important to not have huge increases or decreases in water levels. Drought certainly impacts the wild rice beds.” McLester says the Oneida have restored about 35 acres of wetlands for wild rice production in recent years. He hopes the tribal members on the wild rice council can share best practices for the resource. It’s also possible the committee will propose new regulations to protect wild rice. A First Nations family in Canada is demanding answers after 24-year-old Jaali Sutherland-Weenie died during childbirth after reportedly being diagnosed with pre-eclampsia while 36 weeks pregnant. Family members say Sutherland-Weenie, from Beardy's and Okemasis’ Cree Nation in Saskatchewan, sought medical care in the days leading up to her death and raised concerns about symptoms linked to the dangerous pregnancy complication. According to the Mayo Clinic, pre-eclampsia causes high blood pressure during pregnancy and can quickly become life-threatening for both mother and baby if not closely monitored and treated. According to relatives, Sutherland-Weenie first went to a hospital in Rosthern before being transferred to Jim Pattison Children's Hospital and later to the labor and delivery unit at Royal University Hospital in Saskatoon, where she died on April 26 after giving birth to her daughter. Her death is now drawing attention from Indigenous advocates and community members who say Indigenous women continue to face inequities in maternal health care and are too often dismissed when reporting pain or complications. Loved ones are calling for accountability and a full review into what happened. Community members have also taken to social media to share condolences and call for better protections for Indigenous mothers navigating the health care system. The Saskatchewan Health Authority says a review is underway. Blayne Morin, Sutherland-Weenie's partner, said during a news conference held at Wanuskewin Heritage Park in Saskatoon, Saskatchewan earlier this week, he plans to attend her graduation ceremony next month to accept her degree on her behalf. Morin says the couple wanted to build a better life for their daughter than the ones they experienced growing up. “The family and I will be attending her congregation next month, taking her degree, and we planned so much for our baby before she made her appearance here. We didn't want her to grow up like how we did, breaking the intergenerational trauma.” Sutherland-Weenie leaves behind a newborn daughter and a grieving family now hoping her story raises awareness about the warning signs of pre-eclampsia and the importance of timely medical care. Get National Native News delivered to your inbox daily. Sign up for our daily newsletter today. Download our NV1 Android or iOs App for breaking news alerts. Check out today’s Native America Calling episode Thursday, May 28, 2026 — Exploring home, culture, and personal resolve with writers Joan Kane and Sherman Funmaker

Brain donation is helping researchers better understand why Alzheimer's disease and related neurodegenerative disorders develop, progress, and affect people differently.Dr. Melissa Murray is a professor of neuroscience at Mayo Clinic in Jacksonville, Florida, where her research focuses on the biological changes, including tauopathies, that drive Alzheimer's and related neurodegenerative disorders.. At Mayo Clinic Florida she helps direct one of the world's largest brain banks focused on these diseases, giving scientists access to donated brain tissue that can reveal details about diagnosis, disease progression, genetics, resilience and risk that cannot always be seen during life.In this conversation with Being Patient's Mark Niu, Murray explains what tauopathies are, how tau and amyloid contribute to Alzheimer's disease, and why brain banks are essential to understanding the many ways dementia can appear. She also discusses how brain donation can support biomarker development, genetic discoveries, and more specific diagnoses. She emphasizes that brain donation also offers families answers and helps researchers work toward better ways to detect, treat, and ultimately prevent neurodegenerative disease.----If you loved listening to this Live Talk, visit our website to find more of our Alzheimer's coverage and subscribe to our newsletter: https://www.beingpatient.com/Follow Being Patient: Twitter:   / being_patient_  Instagram:   / beingpatientvoices  Facebook:   / beingpatientalzheimers  LinkedIn:   / being-patient  Being Patient is an editorially independent journalism outlet for news and reporting about brain health, cognitive science, and neurodegenerative diseases. In our Live Talk series on Facebook, former Wall Street Journal Editor and founder of Being Patient, Deborah Kan, interviews brain health experts and people living with dementia. Check out our latest Live Talks: https://beingpatient.com/live-talks/

Host: Darryl S. Chutka, M.D.  Guest: Michael Mueller, M.D.  Fibromyalgia is a chronic health problem commonly seen in a primary care setting. It can be challenging to diagnose and even more so to manage. It can have a devastating effect on a patient's lifestyle, and patients will commonly go from provider to provider seeking relief for their chronic symptoms. We now have a better understanding of the pathophysiology of fibromyalgia; unfortunately, the treatment remains less than optimal. What do we know regarding the cause of the symptoms in fibromyalgia? How can we efficiently establish a diagnosis in patients with the condition without excessive testing? How do we explain the disorder to patients and what's the long-term outlook for patients? These are some of the questions I'll be asking my guest, Dr. Michael Mueller, an internist in the Division of General Internal Medicine at the Mayo Clinic as we discuss “Fibromyalgia”.  Connect with us! Mayo Clinic Talks Podcast Season 6 | Mayo Clinic School of Continuous Professional Development 

Long COVID isn't just lingering fatigue. It's a complex, often life-altering condition that can follow even mild or unnoticed infections. Listen in as Mayo Clinic's Dr. Stephanie Grach breaks down what we really know about Long COVID, who's at risk, and why believing and individualizing care for patients is absolutely critical.   In this episode, Therese Markow and Dr. Stephanie Grach discuss the emergence and impact of Long COVID. Dr. Grach explains that Long COVID affects an estimated 18 million Americans with a wide variety of symptoms that can manifest differently from patient to patient, influenced by a variety of factors, such as viral variant, genetics, and immune responses. Dr. Grach emphasizes the importance of individualized treatment and highlights ongoing research and the need for better understanding and management of this complex chronic condition.     Key Takeaways: Long COVID can look very different from person to person, with over 200 symptoms. However, common symptoms can include fatigue, brain fog, shortness of breath, changes in smell, and more, affecting nearly every organ system.  The larger proportion of people with Long COVID had multiple COVID infections, partly because of sheer numbers - each additional infection is another opportunity for post-acute symptoms to develop or worsen.  The presentation of the Long COVID symptoms is not going to be consistent - patients may have good weeks and feel pretty close to normal, as well as bad weeks, where the symptoms are at their strongest.  Telling someone to "push through" on the assumption that it will just get better really isn't what helps the Long COVID patients.   "Long COVID is real. Patients deserve to be believed, and treatment should be individualized, rather than trying to fit or wait for a one-size-fits-all." —  Dr. Stephanie Grach   Connect with Dr. Stephanie Grach: Professional Bio: https://www.mayoclinic.org/biographies/grach-stephanie-l-m-d-m-s/bio-20536370  LinkedIn: https://www.linkedin.com/in/stephaniegrach    Connect with Therese: Website:  www.criticallyspeaking.net Bluesky: @CriticallySpeaking.bsky.social Instagram: @criticallyspeakingpodcast Email: theresemarkow@criticallyspeaking.net     Audio production by Turnkey Podcast Productions. You're the expert. Your podcast will prove it. 

Rochester is America's City for Health. It's the home of the world-famous Mayo Clinic. Listen to how the mayor of Rochester manages a city with this huge partner. And learn how to move with the mayor. Brought to you by The Good Government Institute, bringing together proven ideas, principled leaders, and real-world solutions to strengthen how we govern—not by reinventing the system, but by advancing what already works. GoodGovernmentShow.com Thanks to our sponsors: HelloNation Ourco Good News For Lefties (and America!) - Daily News for Democracy (Apple Podcasts | Spotify) How to Really Run a City Leading Iowa: Good Government in Iowa's Cities (Apple Podcasts | Spotify) The Context: A Podcast by the Charles F. Kettering Foundation The Good Government Show is part of The Democracy Group, a network of podcasts that examines what's broken in our democracy and how we can work together to fix it. The Royal Cousins: How Three Cousins Could Have Stopped A World War by Jim Ludlow Executive Producers: David Martin, David Snyder, Jim Ludlow Host/Reporter: David Martin Producers: David Martin, Jason Stershic Editor: Jason Stershic

Handheld Ultrasound and Detection of Valve and Other Structural Heart Disease   Guest: Jared Bird, M.D. Host: Paul Friedman, M.D.   Handheld ultrasound is rapidly changing cardiovascular structural heart disease assessment by allowing clinicians and researchers to detect valvular and structural heart disease earlier and more accurately. Advances in AI imaging guidance and interpretation further bridge the gap between physical exam and formal comprehensive echocardiography. It is important to realize how complimentary handheld ultrasound can be in the early detection of structural heat disease but does not replace diagnostic echocardiography.   Topics Discussed: How does handheld ultrasound improve upon the traditional physical exam when it comes to identifying valvular or structural heart disease? What are the most common valve or structural abnormalities that clinicians can reliably detect using handheld ultrasound today? How are we using handheld ultrasound to screen patients for structural heart disease in a research setting? How do AI-ECG and handheld ultrasound intersect to provide optimal screening of asymptomatic patients with structural heart disease?   Connect with Mayo Clinic's Cardiovascular Continuing Medical Education online at https://cveducation.mayo.edu or on Twitter @MayoClinicCV and @MayoCVservices. LinkedIn: Mayo Clinic Cardiovascular Services Cardiovascular Education App: The Mayo Clinic Cardiovascular CME App is an innovative educational platform that features cardiology-focused continuing medical education wherever and whenever you need it. Use this app to access other free content and browse upcoming courses. Download it for free in Apple or Google stores today! No CME credit offered for this episode.   Podcast episode transcript found here.   Recorded on: 30-December-2025

What if you could detect Alzheimer's years before any symptoms appeared and stop it?Dr. Yogesh Shah is a Board-Certified Geriatrician and Mayo Clinic-trained memory specialist who has spent 25 years focused entirely on the early detection and prevention of dementia. In this episode, he makes a case that every entrepreneur in their 40s and 50s needs to hear: the window to protect your brain is now. Not at 70. Not after a diagnosis.America spends 20% of its GDP on healthcare, and nearly all of it goes to disease management. Dr. Shah explains why that approach is failing, what Mild Cognitive Impairment is and why it matters, and how a new FDA-approved blood test can identify Alzheimer's pathology years before any symptoms appear. He walks through the 14 lifestyle factors identified in the Lancet study that can reduce dementia risk by up to 45%, and explains how monoclonal antibody infusions are now removing amyloid plaque from the brains of patients caught early enough.What you will walk away with: an understanding of why 40 to 50% of dementia cases go undiagnosed and the real-world consequences, what the new p-tau blood tests are and how to ask your doctor about getting one, which lifestyle factors carry the most risk weight for entrepreneurs, and why managing your LDL, sleep, social connection, and chronic conditions in midlife is the most important thing you can do for your future brain health.Connect with Dr. Yogesh Shah on LinkedIn Hosted by John St. Pierre and Rich Hoffmann, Entrepreneurs United is built for founders and leaders who want straight talk on building businesses that actually work. New episodes every week.https://entrepreneursunited.us/links/

With Edoardo Conte and Daniele Andreini, Galeazzi-Sant'Ambrogio Hospital IRCCS, Milan - Italy and Gal Tsaban, Mayo Clinic, Rochester - USA. Link to paper Link to editorial

In this episode of the Chasing Giants Podcast, Don Higgins returns after spending time helping Robin recover from major surgery at Mayo Clinic. Don shares an emotional update on Robin's condition, the road ahead with chemo treatments, and thanks the Chasing Giants family for the overwhelming prayers and support. Terry also recaps an unforgettable Manitoba black bear hunt filled with giant bears, unbelievable footage, close encounters, and stories that will eventually become two full Chasing Giants TV episodes. The guys also dive into: Spring food plot challenges and excessive rain Soybean planting strategies and browse pressure The upcoming “Doubting Thomas” video release Why Scrape Magnet played a major role in Don's success Michigan becoming a one-buck state Supplemental feeding vs baiting Why mature bucks become nocturnal Sanctuary intrusion and fawn survival As always, the show blends faith, deer hunting, land management, and real-life perspective. Please continue praying for Robin and the Higgins family. Sponsors: Asio Gear – https://asiogear.com Real World Wildlife Products – https://realworldwildlifeproducts.com Hawke Optics – https://us.hawkeoptics.com Novix Outdoors – https://novixoutdoors.com Midwest Land Group – https://midwestlandgroup.com 360 Hunting Blinds – https://360huntingblinds.com Mike's Mighty Micros – https://mikesmightymicros.com Gingerich Tree Farm – https://gingerichtreefarm.com TagOut Technique – https://tagouttechnique.com Grubb Implement – https://grubbimplement.com Brenton USA – https://brentonusa.com Mathews Archery – https://mathewsinc.com Victory Auto Group – https://victorykc.com Wildlife Farming – https://wildlifefarming.com WiseEye Technologies – https://wiseeyetech.com DISCLAIMER: The views and opinions expressed in this podcast are those of the hosts and guests and do not necessarily reflect the official policy or position of any sponsors or affiliated companies. © Chasing Giants. All rights reserved. This content may not be reproduced or distributed without written permission.

"When you have benign conditions, we're actually treating 3 gray, so a significant difference [versus doses of 60 gray for brain cancer]. Typically, when you treat at a high dose, the goal is to destroy tissue, like cancer tissue or cancer cells. But when we give a low dose, the goal is actually to modulate inflammation. And what it does is it slows down those inflammatory cells or those cells that release the chemicals that cause pain and inflammation," Amanda Meyer, DNP, APRN, CNP, family nurse practitioner in the Department of Radiation Oncology at the Mayo Clinic in Rochester, MN, told Jaime Weimer, MSN, RN, AGCNS-BS, AOCNS®, manager of oncology nursing practice at ONS, during a conversation about radiation therapy for noncancer indications. Music Credit: "Fireflies and Stardust" by Kevin MacLeod Licensed under Creative Commons by Attribution 3.0  Earn 0.25 contact hours of nursing continuing professional development (NCPD) by listening to the full recording and completing an evaluation at courses.ons.org by May 22, 2027. The planners and faculty for this episode have no relevant financial relationships with ineligible companies to disclose. ONS is accredited as a provider of nursing continuing professional development by the American Nurses Credentialing Center's Commission on Accreditation. Learning outcome: Learners will report an increase in knowledge about the use of radiation to treat noncancerous conditions. Episode Notes  Complete this evaluation for free NCPD.  ONS Podcast™ episodes: Episode 365: Radiation-Associated Secondary Cancers Episode 301: Radiation Oncology: Side Effect and Care Coordination Best Practices ONS Voice articles: Augmented Reality Simulations Reduce Patient Anxiety by Teaching Them About Radiation Therapy Highly Localized, Precision Radiation Therapies Require Nurses to Drive Care Coordination, Patient Education Quick Quiz: Test Your Knowledge of Radiation Care Coordination ONS book: Manual for Radiation Oncology Nursing Practice and Education (fifth edition) ONS courses: ONS Radiation Oncology Conference Recordings Bundle™ ONS ROCN™ Certification Review™ Radiation Oncology 101: 2024 ONS Bridge™ Session ONS/ONCC® Radiation Therapy Certificate™ Clinical Journal of Oncology Nursing articles: Findings From the 2023 Radiation Oncology Nursing Role Delineation Study to Shape the Future of the Subspecialty The Role of Advanced Practice Providers in Radiation Oncology in 2025 ONS Huddle Cards: Radiation Radiobiology German Society for Radiation Oncology (DEGRO): Guidelines in Radiotherapy: Radiotherapy for Benign Diseases To discuss the information in this episode with other oncology nurses, visit the ONS Communities. To find resources for creating an ONS Podcast club in your chapter or nursing community, visit the ONS Podcast Library. To provide feedback or otherwise reach ONS about the podcast, email pubONSVoice@ons.org. Highlights From This Episode "We always typically think of it as cancer treatment, but we can use radiation for noncancerous conditions, as well. And radiation was actually used for benign diseases right after the discovery of x-rays. By the 1920s it was used a lot for different types of musculoskeletal, dermatologic issues, and different types of inflammatory conditions. And over time, since the 1920s, we've actually really gotten a really good understanding of it." TS 1:37 "When we're looking at what are good candidate characteristics, we do typically like older patients, so patients over the age of 65. And the rationale behind that is we know that there is a potential for a secondary risk of a skin cancer about 20 to 30 years after getting low-dose radiation, like a basal cell or squamous cell skin cancer. The older the patient is, the less likely they are to have any adverse effects from that." TS 8:22 "When we do the low-dose radiation, they've tried other measures that haven't been successful. However, we don't want a patient who is so severe that they're ready for surgery, when they're bone on bone, because we know that radiation isn't as effective when they are that severe. So there's this sweet window where low-dose radiation works best in these patients." TS 9:39 "When we're treating with a little bit higher dose for like a Dupuytren's or a Ledderhose, because it's an anti-proliferative dose, those patients, they do get more skin redness, more dry skin. That's very temporary, and it resolves within a week or two after treatment. But really, we don't see any acute side effects. The long-term side effect of the radiation-induced malignancy, again, is a very low—0.05% according to some of the European guidelines." TS 12:34 "I really wish people appreciated how interdisciplinary this is. We need to get referrals from family medicine and from primary care and internal medicine and pain medicine physicians and inflammatory physicians and podiatry and pain specialists. And we really need to use this multidisciplinary approach to get earlier referrals for patients because there is this sweet window of time where low-dose radiation works the best." TS 18:40

Darshan Shah, MD is a board-certified surgeon, published author, and Founder and CEO of Next Health – the first, largest and fastest-growing health optimization and longevity clinic. He earned his medical degree at the age of 21 from the University of Missouri-Kansas City, becoming one of the youngest doctors in the United States at the time. He continued his training at the Mayo Clinic and earned his MBA from Harvard Business School. As a longevity medicine specialist, he has advised thousands of patients on how to optimize their well-being and extend their healthspan and lifespan. Today on the show we discuss why living longer means nothing if your health span is broken, the biggest mistakes people make when chasing longevity, why most people should focus on metabolic health before biohacking, the blood markers Dr. Shah believes everyone should track, how strength training, walking, sleep, and nutrition protect your future, why ultra-processed foods are quietly wrecking your health, the truth about alcohol, weed, caffeine, fasting, sauna, cold plunge, red light therapy, wearables, supplements, NAD, and how toxins, stress, relationships, and circadian rhythm all impact how well you age. And much more.  Today's sponsor: Fatty15:  Get an additional 15% off their 90-day subscription Starter Kit by going to fatty15.com/DOUG and using code DOUG at checkout Learn more about your ad choices. Visit megaphone.fm/adchoices

Host: Darryl S. Chutka, M.D  Guest: Mark D. Tyson, III, M.D., M.P.H.  Bladder cancer is one of the most common malignancies worldwide, and primary care clinicians are often the first to evaluate patients with bladder cancer. The symptoms are usually subtle and may include either gross or microscopic hematuria. The decision in whether to investigate these presenting symptoms can often impact early diagnosis and the patient's outcome. When should we investigate hematuria? What should an evaluation of hematuria consist of? What is the treatment for bladder cancer? How should patients with recurrent bladder cancer be managed? What role does the primary care clinician play in the long-term management of patients? I'll be asking these questions and more of my guest, Dr. Mark Tyson, a urologist at the Mayo Clinic as we discuss “Bladder Cancer”.  Connect with us! Mayo Clinic Talks Podcast Season 6 | Mayo Clinic School of Continuous Professional Development 

Dr. Megha Tollefson, Department Chair of Dermatology, Professor of Pediatrics and Dermatology at the Mayo Clinic, and PeDRA President-Elect, shares her key takeaways from the PeDRA session at SID.

Host: Darryl S. Chutka, M.D.  Guest: Stacey Rizza, M.D.  Hantavirus has been in the news lately. Although it's rare, it can cause serious disease which can be life-threatening.  Early symptoms are similar to other common viral infections including fever, myalgias, headache, and fatigue. As a result, the ability to establish an early diagnosis is challenging. Who's at risk of acquiring Hantavirus? Does it have the potential to become our next pandemic? How likely is human-to-human transmission? Is there any effective treatment and what preventive measures should one take to minimize the acquisition of the disease? I'll get answers to these questions in this podcast as we discuss Hantavirus. My guest is an infectious disease specialist, Dr. Stacey Rizza from the Mayo Clinic.  Connect with us! Mayo Clinic Talks Podcast Season 6 | Mayo Clinic School of Continuous Professional Development 

In this episode, Raj, Ashwin, and Eddie sit down with Dr. Vincent Rajkumar — Professor of Medicine at Mayo Clinic and Chair of the ECOG Myeloma Committee — for a clinically focused conversation on newly diagnosed multiple myeloma. Topics span baseline workup, risk stratification, induction selection, transplant timing, MRD-directed decision-making, and maintenance strategy. The episode closes with a discussion of Open Medicine, a new medical education platform, and Dr. Rajkumar's ongoing advocacy on drug pricing reform.KEY TOPICS DISCUSSEDBaseline workup: 24-hour urine protein: It is important to obtain 24-hour urine protein with electrophoresis and immunofixation in all newly diagnosed patients — not for diagnosis, but to establish a baseline for long-term management and to distinguish M-protein from albuminuria. In patients where an FLC ratio ≥100 is the sole myeloma-defining criterion, a 24-hour urine Bence Jones protein ≥200 mg is part of the diagnostic threshold for treatment initiation. Myeloma cast nephropathy: when to biopsy: An involved FLC ≥50 mg/dL supports a presumptive diagnosis of cast nephropathy and treatment can begin without a kidney biopsy. Below this threshold — particularly if renal involvement is the sole myeloma-defining event — kidney biopsy is warranted to exclude light chain deposition disease, MPGN, or other unrelated disorders. It warrants aggressive early treatment (Dara-VCD or Dara-VD), starting even before bone marrow results are available when the diagnosis is clinically clear.Solitary plasmacytoma [with or without minimal bone marrow involvement]: Patients with ~10% clonal plasma cells technically meet criteria for myeloma, but management in this borderline zone warrants shared decision-making. Solitary plasmacytoma as sitting between smoldering myeloma and overt myeloma on the disease spectrum. Risk stratification: revised IMWG criteria: The new revision aimed to keep the high-risk designation to ≤15–20% of patients. Del 17p alone confers high-risk status. TP53 mutation without del 17p is exceedingly rare and FISH alone captures the vast majority of cases. All other cytogenetic abnormalities (t(4;14), t(14;16), t(14;20), 1q gain, 1p deletion, biallelic 1p) require at least one co-occurring abnormality to define high risk. Elevated β2-microglobulin with normal renal function is retained as a proxy for high tumor burden. Emergent indications for treatment initiation: The three situations warranting urgent treatment are acute cast nephropathy (days matter for renal recovery), cord compression (surgery vs. radiation vs. systemic therapy determined by acuity), and hypercalcemia. Induction regimen selection: For fit, transplant-eligible patients, the preferred induction is a quadruplet — Dara-VRd or Isa-VRd — with dose adjustment as needed. Triplets (Dara-Rd or Isa-Rd) are reserved for those unable to tolerate a quadruplet even with dose reduction. Carfilzomib-based induction is not favored: head-to-head data show no benefit of KRd over VRd in NDMM, and the cost differential is substantial. Lenalidomide dosing: Starting dose should be individualized: 15 mg for patients over 75, those with small body habitus (

What Do I Need to Know About Pulsed Field Ablation?   Guest: Christopher DeSimone, Host: Anthony Kashou, M.D.   In this episode of “ECG Making Waves, hosted by Dr. Anthony Kashou with guest Dr. Christopher DeSimone, the focus is on understanding the evolution of ablation technology, particularly why the field has shifted toward pulsed field ablation. The conversation explores the key differences between traditional thermal ablation methods and pulsed field ablation, highlighting mechanisms, safety profiles, and clinical advantages. Additionally, it provides insight into what patients and clinicians can expect on the day of an ablation procedure, as well as important considerations for post-procedure follow-up and recovery.   Topics Discussed: What is pulsed field ablation? What are some of the differences between risks seen with thermal ablation vs. those seen with pulsed field ablation? How does efficiency of the procedure or speed of the procedure change what you do for ablation?   Connect with Mayo Clinic's Cardiovascular Continuing Medical Education online at https://cveducation.mayo.edu or on Twitter @MayoClinicCV and @MayoCVservices. LinkedIn: Mayo Clinic Cardiovascular Services Cardiovascular Education App: The Mayo Clinic Cardiovascular CME App is an innovative educational platform that features cardiology-focused continuing medical education wherever and whenever you need it. Use this app to access other free content and browse upcoming courses. Download it for free in Apple or Google stores today! No CME credit offered for this episode.   Podcast episode transcript found here.   Recorded on: 28-January-2026

Twin sisters, Kaija and Melija Vijums graduate later this week and already have very important jobs lines up in their field. Find out more about these amazing young women on The WCCO Morning News with Vineeta Sawkar.

Have you ever found yourself having to address a group that you have pretty much nothing in common with? As a comedian and keynote speaker, it happens. Here's a quick story about a time that I had to connect. . .and I did. It's a fun story and I hope you enjoy it.  https://www.TheWorkLady.com  Jan McInnis is a top change management keynote speaker, comedian, and funny motivational speaker who helps organizations use humor to handle change, build resilience, and strengthen leadership skills. With her laugh-out-loud stories and practical tips, Jan shows audiences how humor isn't just entertainment—it's a business skill that drives communication, connection, and stress relief.   A conference keynote speaker, Master of Ceremonies, and comedy writer, Jan has written material for The Tonight Show with Jay Leno as well as radio, TV, and syndicated cartoon strips. She's the author of two books—Finding the Funny Fast and Convention Comedian—and her insights on humor in business have been featured in The Wall Street Journal, The Washington Post, and The Huffington Post. For over 25 years, she has been helping leaders and teams discover how to bounce back from setbacks, embrace change, and connect through comedy.   Jan has delivered keynote speeches at thousands of events nationwide, from the Federal Reserve Banks to the Mayo Clinic, for industries that include healthcare, finance, government, education, women's leadership events, technology, and safety & disaster management. Her client list features respected organizations such as: Healthcare: Mayo Clinic, Kaiser Permanente, Abbott Pharmaceuticals, Health Information Management Associations, Assisted Living Associations Finance: Federal Reserve Banks, Merrill Lynch, Transamerica Insurance, BDO Accounting, American Institute of CPAs, credit unions, banking associations Government: U.S. Air Force, Social Security Administration, International Institute of Municipal Clerks, National League of Cities, public utilities, correctional associations Women's Leadership Events: Toyota Women's Conference, Go Red for Women, Speaking of Women's Health, Soroptimists, Women in Insurance & Financial Services Education: State superintendent associations, community college associations, Head Start associations, National Association of Elementary and Middle School Principals Safety & Disaster: International Association of Emergency Managers, Disney Emergency Management, Mid-Atlantic Safety Conference, risk management associations   Her background as a Washington, D.C. marketing executive gives her a unique perspective that blends business acumen with stand-up comedy. Jan was also honored with the Greater Washington Society of Association Executives "Excellence in Education" Award. Along with her podcast Finding the Funny: Leadership Tips from a Comedian, Jan also produces Comedian Stories: Tales From the Road in Under 5 Minutes. Whether she's headlining a major convention, hosting a leadership retreat, or teaching resilience at a safety conference, Jan's programs give audiences the tools to laugh, learn, and lead.  

Hospitals already have rich patient data. The next step is turning that data into validated, timely insights that help clinicians respond before patients deteriorate. In this episode, Brian Tufts, President & CEO at Ambient Clinical Analytics, joins Saul Marquez at the MedTech Innovator Radar Forum to explore how software-as-a-medical-device is improving critical care workflows. Brian explains how the company, a Mayo Clinic spinout, built an FDA-cleared platform that combines clinical analytics, decision support, and workflow automation to help hospitals monitor complex patients. He highlights tools like Sepsis DART, which enable earlier detection and response by embedding hospital-specific protocols directly into workflows. Brian also underscores that AI in healthcare must be validated, structured, and carefully implemented, not left to unproven models making clinical decisions. Tune in to learn how hospitals can better leverage data to improve patient care in a thoughtful, reliable way. Resources: Connect with and follow Brian Tufts on LinkedIn. Follow Ambient Clinical Technologies on LinkedIn and explore their website here.

In this episode, Molly Gamble, Vice President of Editorial at Becker's Healthcare, discusses Mayo Clinic's announced CEO transition and what it signals for the future of health system leadership.

In this episode of “Answers From the Lab,” host Bobbi Pritt, M.D., chair of the Division of Clinical Microbiology at Mayo Clinic, welcomes Brad Karon, M.D., Ph.D., division chair for Mayo Clinic's Clinical Core Laboratory Services and a member of the laboratory and pathologist stewardship team, to discuss laboratory stewardship strategies and why they matter.Why lab stewardship is important (00:44): How improved test utilization benefits laboratories, healthcare systems, and patients.Strategies for promoting lab stewardship (03:40): Proven approaches for improving appropriate test utilization.How industry disrupters will change stewardship efforts (09:33): How artificial intelligence and other emerging disruptors may reshape lab stewardship efforts.Note: Information in this post was accurate at the time of its posting.ResourcesFroedtert and the Medical College of Wisconsin: Promoting laboratory stewardship through clinical decision supportFive steps to optimizing your outreach test menuHospital-owned labs generate long-term financial and clinical value

The San Francisco Comedy Competition is a very prestigious comedy competition. Comics are thrilled when they get invited, and that happened to me. Here's a quick story about my exeperience in the competition, and what I got out of it. I believe the competition is still going strong, so if you're a comedian, go for it! https://www.TheWorkLady.com  Jan McInnis is a top change management keynote speaker, comedian, and funny motivational speaker who helps organizations use humor to handle change, build resilience, and strengthen leadership skills. With her laugh-out-loud stories and practical tips, Jan shows audiences how humor isn't just entertainment—it's a business skill that drives communication, connection, and stress relief.   A conference keynote speaker, Master of Ceremonies, and comedy writer, Jan has written material for The Tonight Show with Jay Leno as well as radio, TV, and syndicated cartoon strips. She's the author of two books—Finding the Funny Fast and Convention Comedian—and her insights on humor in business have been featured in The Wall Street Journal, The Washington Post, and The Huffington Post. For over 25 years, she has been helping leaders and teams discover how to bounce back from setbacks, embrace change, and connect through comedy.   Jan has delivered keynote speeches at thousands of events nationwide, from the Federal Reserve Banks to the Mayo Clinic, for industries that include healthcare, finance, government, education, women's leadership events, technology, and safety & disaster management. Her client list features respected organizations such as: Healthcare: Mayo Clinic, Kaiser Permanente, Abbott Pharmaceuticals, Health Information Management Associations, Assisted Living Associations Finance: Federal Reserve Banks, Merrill Lynch, Transamerica Insurance, BDO Accounting, American Institute of CPAs, credit unions, banking associations Government: U.S. Air Force, Social Security Administration, International Institute of Municipal Clerks, National League of Cities, public utilities, correctional associations Women's Leadership Events: Toyota Women's Conference, Go Red for Women, Speaking of Women's Health, Soroptimists, Women in Insurance & Financial Services Education: State superintendent associations, community college associations, Head Start associations, National Association of Elementary and Middle School Principals Safety & Disaster: International Association of Emergency Managers, Disney Emergency Management, Mid-Atlantic Safety Conference, risk management associations   Her background as a Washington, D.C. marketing executive gives her a unique perspective that blends business acumen with stand-up comedy. Jan was also honored with the Greater Washington Society of Association Executives "Excellence in Education" Award. Along with her podcast Finding the Funny: Leadership Tips from a Comedian, Jan also produces Comedian Stories: Tales From the Road in Under 5 Minutes. Whether she's headlining a major convention, hosting a leadership retreat, or teaching resilience at a safety conference, Jan's programs give audiences the tools to laugh, learn, and lead.  

What if the biggest threat to your success in medical training has nothing to do with how much you study? Vance Lehman, professor of neuroradiology and chief of neuroradiology education at the Mayo Clinic, spent over two years researching why capable trainees stumble despite strong clinical knowledge. In this episode, based on his KevinMD article "The hidden curriculum: What medical school does not teach you," he explains how unspoken expectations, invisible social dynamics, and stealth influences shape evaluations and career trajectories far more than most trainees realize. You will learn why making a strong first impression on a new rotation triggers a powerful psychological feedback loop, how generational biases from attendings quietly distort trainee evaluations, and why years of excelling at test scores can actually leave you blind to the skills that matter most in clinical settings. Lehman also shares practical steps any medical student or resident can take tomorrow to stop leaving their reputation to chance. If you are in medical training or teach those who are, this episode reveals the forces you feel every day but have never had a name for. Tune into our episode "2026 Cholesterol Guidelines: LDL goals, lipoprotein(a), and coronary calcium scoring," brought to you by Novartis Pharmaceuticals Corporation. For the first time in eight years, LDL cholesterol goals have changed, and preventive cardiologist Seth Baum says the new guidelines are a long-overdue course correction. He breaks down the new LDL targets for your highest-risk patients, why the LDL hypothesis should be retired in favor of the LDL fact, why lipoprotein(a) screening finally belongs in every patient's workup, what a coronary calcium score over 300 really means for how aggressively you treat, and how to talk to statin-skeptical patients without losing their trust. Listen now at KevinMD.com/cholesterol. VISIT SPONSOR → https://kevinmd.com/cholesterol Partner with me on the KevinMD platform. With over three million monthly readers and half a million social media followers, I give you direct access to the doctors and patients who matter most. Whether you need a sponsored article, email campaign, video interview, or a spot right here on the podcast, I offer the trusted space your brand deserves to be heard. Let's work together to tell your story. PARTNER WITH KEVINMD → https://kevinmd.com/influencer SUBSCRIBE TO THE PODCAST → https://www.kevinmd.com/podcast RECOMMENDED BY KEVINMD → https://www.kevinmd.com/recommended

Today we're joined by Kahlen Darr, a genetic counselor at Mayo Clinic who specializes in inherited retinal and complex genetic disorders. We're diving into how genetic testing works in ophthalmology and what clinicians need to know. Don't miss this one!  Subscribe to the podcast:  https://MayoClinicOphthalmology.podbean.com   Follow and reach out to us on X and IG: @mayocliniceye 

Editor's Choice:  Optimization of methylated DNA markers to rule out endometrial cancer in patients with abnormal uterine bleedingEditorial: Tampon-based methylated DNA testing for endometrial cancer: Promising innovation, but prudence before practiceHosted by: Charles N. Landen Jr., MD; University of Virginia Charlottesville, VA, USAFeaturing: Jamie N. Bakkum-Gamez, MD; Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, MN, USAJohn B. Kisiel, MD; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USAJoy M. Davis MD; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USACheck out more content on the journal's homepage  at https://www.gynecologiconcology-online.net

What do you do when you know something is wrong… but there is no clear diagnosis, no obvious treatment plan, and no quick fix? In this episode of Aligned Vitality, Tanya shares a personal reflection after a recent visit to the Mayo Clinic with her husband, who has been dealing with chronic lung and sinus issues, ongoing inflammation, anxiety around his symptoms, and years of frustration searching for answers. While the visit brought relief in some ways, it also confirmed something deeply important: the absence of a major diagnosis does not always mean the presence of health. This conversation explores the gap between “not diagnosed” and “truly well,” the role of chronic inflammation, metabolic dysfunction, stress, and lifestyle habits in long-term unwellness, and why so many people want a quick fix when what they really need is a foundation for healing. Tanya also talks about the emotional reality of being in the “wanting phase” of health change, why people often feel overwhelmed by the whole picture, and how healing usually begins not with a dramatic overhaul, but with one small step at a time. If you've ever felt like something was off in your body but could not get clear answers, this episode will help you feel seen, informed, and hopeful. In This Episode What the Mayo Clinic confirmed about inflammation, stress, and lifestyle Why feeling unwell often starts long before disease gets a diagnosis The difference between symptom management and health building Why conventional medicine and functional health ask different questions The emotional toll of chronic symptoms without clear answers Why some people stay in the “wanting phase” of health change How to begin making lifestyle changes without overwhelm Why healing often starts with small, consistent steps Key Takeaway The absence of a diagnosis does not always mean the presence of health. Sometimes the body has been under strain for years before disease gets a name — and healing begins not with a quick fix, but with consistent choices that support the way the body was designed to heal.   I hope this episode blesses you! Xoxo, Tanya   Book a FREE functional health discovery call HERE.   Episode Resources: Episode Catalog   My trusted Supplement Dispensary: Aligned Vitality Fullscript Dispensary My trusted Telehealth Peptide Provider:  EllieMD_Tanya Engesether *I do get a small commission when you use one of the above affiliate links. 3 Ways To Connect With Me: 1️⃣COACHING: Are you READY to Lead Well, Live Well and BE Well? Book a FREE discovery call with me to find out more about functional health coaching. It's the accountability and guidance you need to reclaim your health and happiness! ➡︎ https://alignedvitalityhealth.com/coaching   2️⃣ FACEBOOK: Become part of our Supportive Facebook Group. Connect, share, and learn with others navigating life and leadership ➡︎ https://alignedvitalityhealth.com/community   3️⃣ CONTACT: Leave me a question or comment ➡︎ https://alignedvitalityhealth.com/contact   "Yes! Finally, a podcast helping others become the thriving leaders they're meant to be outside of hustle-culture! This is an amazing resource! Thank you so much for sharing and helping us become Spirit-driven, peaceful leaders!"    If you can relate, please consider rating and reviewing my show! It helps me reach more people – just like you – to help them change their future. Don't forget to follow the show so you don't miss any episodes! And, if you're feeling really generous, I'd be SO honored if you would share this podcast with someone.   Click here to view our privacy policy.   Reminder:  The information you hear on this show is not meant to diagnose, treat, cure or prevent disease.  It is for educational purposes only. Always consult with your own health practitioner before you make any changes to your health.

Host: Darryl S. Chutka, M.D.   Guest: Joseph Murray, M.D.  Celiac Disease affects approximately 1% of the population worldwide and can present at any age, frequently with very subtle, atypical or at times entirely non-GI symptoms. The presentation can be extremely diverse and may involve a variety of organ systems. If not recognized and effectively treated, multiple potentially serious complications can develop. Primary care clinicians are often the initial point of contact, and we need to know the common presenting symptoms, which tests should be ordered when we suspect the disease and when a referral is necessary. We also play a role in long-term management by monitoring for nutritional deficiencies, bone integrity, and the patient's adherence to a gluten-free diet. In this podcast, we'll explore Celiac Disease with my guest, Dr. Joseph Murray, a gastroenterologist from the Mayo Clinic, and a nationally recognized specialist in Celiac Disease. We'll focus on practical information you can apply to your practice.  Connect with us! Mayo Clinic Talks Podcast Season 6 | Mayo Clinic School of Continuous Professional Development 

Cardiovascular Care of the Masters Athlete   Guest: Kathryn Larson, M.D. Host: Sharonne Hayes, M.D.   In this podcast, Dr. Kathryn Larson will discuss current research on the influence of exercise on cardiovascular physiology and health. Specifically, she will discuss her research on the effects of life-long endurance exercise exposures on cardiac function and exercise capacity, particularly as it pertains to female masters athletes. This unique population can serve as an important model of healthy cardiovascular aging and offer therapeutic insights into how exercise truly is an effective therapy.   Topics Discussed: On a “big picture” scale, what is interesting and unique about older adults who continue to maintain a high level of exercise training? Aging and the accumulation of cardiac and non-cardiac diseases clearly impact cardiovascular function over time. What lessons can we learn from masters athletes on how things like aging, menopause, and cardiovascular disease interact with a life-long habit of exercise? What are some of the challenges that come with studying masters athletes? Is there such a thing as “too much exercise?”   Connect with Mayo Clinic's Cardiovascular Continuing Medical Education online at https://cveducation.mayo.edu or on Twitter @MayoClinicCV and @MayoCVservices. LinkedIn: Mayo Clinic Cardiovascular Services Cardiovascular Education App: The Mayo Clinic Cardiovascular CME App is an innovative educational platform that features cardiology-focused continuing medical education wherever and whenever you need it. Use this app to access other free content and browse upcoming courses. Download it for free in Apple or Google stores today!   No CME credit offered for this episode.   Podcast episode transcript found here. Recorded on 09-December-2026.

Part 2 of the Women's Health SeriesYour digestion suddenly feels different, your sleep is falling apart, your mood and patience are all over the place — and you start wondering whether it's stress, aging, or something bigger. Joined by two extraordinary Mayo Clinic experts, Drs. Chrisandra Shufelt and Jami Kinnucan, we pull back the curtain on perimenopause and menopause, explaining how shifting estrogen and progesterone can ripple through the entire body — from constipation and bloating to metabolic health, cardiovascular risk, and even the gut microbiome. Most importantly, this episode reminds women that these changes are real, common, and worthy of attention.  • Defining perimenopause versus menopause as a life stage and why symptoms vary so much • Linking estrogen and progesterone changes to motility, constipation, bloating, and visceral sensitivity • Discussing microbiome shifts, dysbiosis, and how gut health may influence estrogen recycling • Outlining cardiometabolic changes including central weight gain, lipid changes, blood pressure, and insulin resistance • Clarifying brain fog, sleep disruption, and increased anxiety and depression risk during perimenopause • Reviewing SSRIs and SNRIs as options that may also reduce hot flashes • Covering bone loss timing, hormone therapy limits, and when DEXA scanning makes sense • Summarizing what is known about IBS symptom severity and what is less clear in IBD • Debunking hormone panels in perimenopause and pointing to menopause-trained clinicians • Breaking down soy, supplements, placebo effects, and lifestyle factors like weight loss and exercise snacks • Detailing vaginal estrogen for dryness, painful sex, and recurrent UTIs, including how to use it correctly This episode has been sponsored by Ardelyx.References for this episode:The 2022 hormone therapy position statement of The North American Menopause SocietyThe association between metabolic dysfunction-associated steatotic liver disease diagnosis and vasomotor symptoms in midlife womenImpact of Menopause and Clinical Considerations in Patients With Inflammatory Bowel DiseaseUnderstanding the sexual concerns of older women presenting for care to women's health clinics: a cross-sectional studyFind a Menopause Practitioner: Menopause.orgLearn more about Kate and Dr. Riehl:Website: www.katescarlata.com and www.drriehl.comInstagram: @katescarlata @drriehl and @theguthealthpodcastOrder Kate and Dr. Riehl's book, Mind Your Gut: The Science-Based, Whole-body Guide to Living Well with IBS.  The information included in this podcast is not a substitute for professional medical advice, examination, diagnosis or treatment.  Always seek the advice of your physician or other qualified health care provider before starting any new treatment or making changes to existing treatment.

Angie King went from contractor to VP of UX Design at US Bank in five years — not because she had all the answers, but because she was the person in the room asking the right questions. She's now the content strategy manager at Mayo Clinic, where she's putting the ORCA framework to work on one of the most complex content systems in healthcare.In this episode of The UX Level-Up Podcast, Sophia and Angie get into what it actually looks like when a veteran content strategist finds a framework that finally clicks — and why Angie believes it's not just career-changing, but field-changing. If you've ever felt like the smartest person in a conversation but struggled to explain why something was off, this episode is for you.LINKS:Register for Angie's Button Conference Talk: https://www.buttonevents.com/2026-sessions/object-oriented-ux-a-content-first-approach-to-meaningful-content-designConnect with Angie on LinkedIn: https://www.linkedin.com/in/angieking/Continue the conversation in the OOUX Forum:Connect with Sophia on LinkedIn: https://www.linkedin.com/in/sophiav/Follow Sophia on Instagram: https://www.instagram.com/sophiavux/Check out the OOUX Website: https://ooux.comFollow Sophia on Medium: https://sophiavux.medium.comInterested in training your team on OOUX? Book a call here: https://calendly.com/ooux/opportunityGet on the Cohort 12 waitlist: https://ooux.com/certificationCheck out Zoe: https://ooux.com/zoe

Every sport has had its watershed moment when a new technology upends the landscape and redefines what's possible. Baseball had torpedo bats, swimming the Lazer swimsuits, road cycling the introduction of aerodynamic carbon frames and in running we are living through an era defined by what were first, and best, described as “super shoes.”  For the last decade, the shoe industry has gone into overdrive to create shoes capable of blending impossible lightness with unbelievable energy return. The holy grail sought by shoe designers in this footwear arms race: crafting the pair of shoes that would propel the first man in history to a sub 2-hour marathon performance.  As of Sunday, we are now officially living in the new sub-2 era, as not one, but two men, Kenya's Sabastian Sawe and Ethiopia's Yomif Kejelcha, tore down the two-hour marathon barrier at last weekend's London Marathon.  While every factor imaginable aligned perfectly for these two men to take the sport somewhere no one has gone before, one factor in particular has drawn the lion's share of attention: the shoes. Both Sawe and Kejelcha ran in the just-released adidas Adios Pro Evo 3, a shoe touted as the lightest, fastest super shoe ever created. This week on The Shakeout Podcast we're diving into what makes these super shoes so super, and what physiological factors they impact that have helped runners achieve times long-thought impossible. To make sense of it all is Olympian and Mayo Clinic exercise physiologist Dr. Shalaya Kipp, a leading thinker in the science of shoe innovation. As one of the first researchers to quantify the running economy-improving benefits of super shoes, Shalaya reveals to us what specific factors are at play in these record-breaking shoes, how our bodies respond to these factors over the marathon distance and why runners of lesser ability might actually benefit the most from this new era of shoe tech.  Subscribe to The Shakeout Podcast feed on Apple, Spotify, YouTube or wherever you find your podcasts. [This collaboration is part of an advertising campaign led by the Podpass agency for Altitude Sports] Shop now at Altitude Sports and enjoy up to 20% off your first order with the promo code “shakeout2026” Click here to order

Hard to detect and almost impossible to treat, pancreatic cancer has long been one of medicine's most ruthless killers. For decades, it's been the cancer that science couldn't crack. But that might be starting to change. Recently, cancer researchers have announced a series of breakthroughs that, taken together, sound almost too good to be true: a drug that targets the “undruggable” gene behind most pancreatic tumors, a personalized mRNA vaccine that teaches the immune system to recognize pancreatic cancer as an enemy, and, now, an AI program that can spot the elusive disease years before doctors typically find it. So is this breakthrough a real turning point? Or another case of medical hype outrunning reality? On today's episode, Dr. Ajit Goenka of the Mayo Clinic joins Derek to walk through the science behind the latest advances in cancer detection and what they could mean for the future of health care. They discuss Dr. Goenka's new research using artificial intelligence to detect pancreatic cancer earlier than ever before … and whether machines might soon see what doctors can't. Subscribe to our YouTube channel here: https://www.youtube.com/@PlainEnglishwithDerekThompson If you have questions, observations, or ideas for future episodes, email us at PlainEnglish@Spotify.com. Host: Derek Thompson Guest: Dr. Ajit Goenka Producer: Devon Baroldi Additional Production Support: Ben Glicksman Learn more about your ad choices. Visit podcastchoices.com/adchoices

It's In The News - where we bring you the top diabetes stories and headlines happening now. This week, Tzield approved down to age one and over, Omnipod trials for fully closed loop, Tandem approved for pregnancy, Eversense 365 launches in Europe, generic Ozempic in Canada, an award for the T1D Barbie and more.  Announcing Community Commericals! Learn how to get your message on the show here. Don't miss our in-person events: www.diabetes-connections.com/events  Learn more about studies and research at Thrivable here Please visit our Sponsors & Partners - they help make the show possible! Omnipod - Simplify Life All about Dexcom  All about VIVI Cap to protect your insulin from extreme temperatures The best way to keep up with Stacey and the show is by signing up for our weekly newsletter: Sign up for our newsletter here Here's where to find us: Facebook (Group) Facebook (Page) Instagram Check out Stacey's books! Learn more about everything at our home page www.diabetes-connections.com  Okay.. our top story this week: XX The U.S. Food and Drug Administration (FDA) approved Tzield (teplizumab-mzwv) for use in children in stage 2 type 1 diabetes (T1D) ages one and older. The approval expands the previous indication from those aged eight and above and was granted under a priority review process. This decision is supported by one-year data from the PETITE-T1D Phase IV study, which evaluated the safety and pharmacokinetics of Tzield in children under eight years old. Tzield was approved for use in individuals 8+ in stage 2 T1D in 2022. Since then, we have been working to expand the eligible population. This expansion effort includes individuals in stage 3 T1D, who can preserve endogenous insulin production for longer when they take Tzield and, most notably today, children in stage 2. https://www.breakthrought1d.org/news-and-updates/tzield-approved-for-children-ages-one-and-older-in-stage-2-t1d/   XX Big write up in the journal Pediatrics about screening for type 1. Citing the 2025 ADA Standards of Care in Diabetes, the opinion piece talks about how to engage the greater healthcare community.  It says: We aim to encourage the development of strategies to emphasize the importance of T1D early detection, integrate screening into routine health care encounters, and support implementation of T1D screening. Pediatricians and other primary care clinicians are well positioned for greater collaboration with the multidisciplinary team, ensuring early detection, timely intervention, and improved outcomes. https://publications.aap.org/pediatricsopenscience/article/2/2/1/207272/Type-1-Diabetes-Screening-in-Pediatrics-Putting?autologincheck=redirected   XX More info about GLP-1 drugs and people with type 1. New study shows off label use did not lead to DKA or pancreatitis in a large 1-year single-center study. Moreover, GLP-1 agonist use in people with T1D was associated with lower overall rates of hospitalization, as has occurred in type 2 diabetes Although GLP-1 agonists are not approved by the FDA for T1D management, off-label adjunctive use has risen for those with obesity. Semaglutide was the most commonly-used GLP-1 (65.5% of GLP-1 users) followed by tirzepatide (23.5%). The rest were using the older-generation drugs: liraglutide or dulaglutide. Lots more information to come on type 1 and glp 1-s in upcoming studies. https://www.medscape.com/viewarticle/use-glp-1s-type-1-diabetes-not-linked-increased-dka-2026a1000d56 XX Health Canada ‌​has approved the first generic ​version of ​Danish ⁠drugmaker ⁠Novo ‌Nordisk's Ozempic drug. In January 2026, the Canadian patent for Ozempic will expire, paving the way for cheap generic versions of the semaglutide injections that help regulate blood sugar levels and appetite. Health Canada said this generic, like existing products, is indicated to be used for the "once-weekly treatment of adult patients with Type 2 diabetes to manage blood sugar levels." With three generics on the market, Tadrous said the price could drop to about $100 or less, depending on their dose. Health Canada said it's currently reviewing eight other generic submissions by different companies and expects to make a decision on these in the next few weeks and months. https://www.cbc.ca/news/health/ozempic-generic-health-canada-9.7180566 XX  Insulet has enrolled the first participant in a pivotal study for its fully closed-loop (FCL)A automated insulin delivery (AID) system for type 2 diabetes (T2D  The participants are between 18 – 75 years of age, living with T2D and using insulin (basal-bolus or basal-only). The Company received Investigational Device Exemption (IDE) approval in March 2026 from the U.S. Food and Drug Administration (FDA). The Company plans to submit a 510(k) filing to the FDA in 2027 and launch its FCL AID system for T2D in 2028.   XX insulet Corporation (PODD) has initiated a voluntary recall of certain lots of its Omnipod 5 insulin delivery Pods in the U.S. after detecting that some devices had a manufacturing defect that causes insulin leakage.   Patients using the affected devices could risk experiencing high blood glucose levels due to insufficient insulin delivery, the Acton, Massachusetts-based MedTech disclosed in a statement late Thursday. The company has already notified the FDA about the recall, which it said will affect nearly 1.5% of Omnipod 5 pod units it manufactures annually. The customers were advised to immediately seek a product replacement at no cost if a Pod from a defective lot is currently in use. https://www.msn.com/en-us/money/companies/insulet-recalling-certain-defective-omnipod-insulin-delivery-devices/ar-AA1YyslT?apiversion=v2&domshim=1&noservercache=1&noservertelemetry=1&batchservertelemetry=1&renderwebcomponents=1&wcseo=1&bundles=feat-es2020-c XX Tandem Diabetes Care (Nasdaq:TNDM) gets FDA clearance for its automated insulin delivery (AID) technology for use in pregnancy. The FDA cleared the company's Control-IQ AID technology for use in what they call: pregnancy complicated by type 1 diabetes mellitus. Tandem says t:slim X2 and Mobi are the first and only commercially available AID systems cleared for use during pregnancy in the U.S. https://www.drugdeliverybusiness.com/tandem-fda-clearance-aid-pregnancy-t1d/ XX Tandem also issued an urgent medical device correction for a software problem with its Mobi insulin pumps. The malfunction may cause insulin delivery to stop, causing high blood sugar if not addressed, the Food and Drug Administration said in a Wednesday recall notice. We told you about this back in October when Tandem sent a letter to customers notifying them of the fault and instructing them to update their pump software as soon as possible. The FDA now issued a class one recall, the most serious type. We just released a bonus episode all about Tanem – tubeless mobi and what else is in the pipeline. You can listen to that wherever you are listening to this.. it's the episode just before this one. https://www.medtechdive.com/news/tandem-recalls-mobi-insulin-pumps-over-software-malfunction/818260/   XX Switching CGMs didn't make a measurable difference for adults using MiniMed's pump system. In a real-world analysis presented at the International Conference on Advanced Technologies & Treatments for Diabetes, researchers found that CGM metrics for patients who switched from the Guardian 4 sensor (MiniMed) to Instinct by Abbott were able to maintain a time in range of greater than 75%. "When it comes to the automated insulin delivery system ... I think the sensor matters less and the system matters more," Viral N. Shah, MD, professor of medicine in the division of endocrinology and metabolism and director of diabetes clinical research at Indiana University Center for Diabetes and Metabolic Diseases, said during a presentation. "Having a different sensor with the system, I think the [glycemic] outcomes will still be what you want." I'm including this because the headline here seemed to indicate no CGM makes a difference, but this study only looked at two. https://www.healio.com/news/endocrinology/20260401/switching-cgm-sensors-does-not-impact-glycemic-outcomes-with-automated-insulin-delivery   XX Vitamin D supplementation may help delay or prevent disease progression in people with prediabetes.. in people who have specific variants in their vitamin D receptor gene. This was found after a second look at large study where researchers found vitamin d really did make a difference.. a second look with people who had a specific gene variation had much better results. "More research is needed to see if there are other factors that are associated with risk reduction." https://www.medicalnewstoday.com/articles/vitamin-d-supplements-help-prevent-type-2-diabetes-right-gene-variants   XX Senseonics (Nasdaq:SENS) announced today that it initiated the first European launch of its Eversense 365 continuous glucose monitor (CGM). The launch comes a few months after the company picked up CE mark for the long-term, implantable CGM in January. Eversense 365 is the world's first 365-day CGM system. It also holds clearance as an integrated CGM (iCGM) system, meaning it can work with compatible medical devices. Those include insulin pumps as part of automated insulin delivery systems, like the Sequel Med Tech twiist system. The company said it made Eversense 365 available to the first patients in Sweden. It plans to bring the sensor to Germany, Spain and Italy in the coming weeks https://www.drugdeliverybusiness.com/senseonics-launches-eversense-365-europe/ XX A machine learning model can improve genetic prediction of type 1 diabetes by as much as 10%, show results from a University of California, San Diego study.   The researchers used the machine‑learning model T1GRS to improve on a gold standard polygenic genetic risk score used to predict who is likely to develop the condition called GRS2. The GRS2 polygenic risk score has been widely tested and can be used to predict newborns who are at high risk of developing type 1 diabetes. While early prediction can't necessarily stop the disease it can help to prevent emergencies like diabetic ketoacidosis at diagnosis, allow families time to prepare and could allow use of therapies to delay onset of the condition. In this study, Gaulton and colleagues carried out a genome‑wide association study in 20,355 people with type 1 diabetes and 797,363 non‑diabetic Europeans, as well as a further analysis around the MHC region in 10,107 diabetic and 19,639 nondiabetic individuals. https://www.insideprecisionmedicine.com/topics/molecular-dx/machine-learning-tool-helps-improve-type-1-diabetes-prediction/ XX Sen. Mark Warner (D-Va.) said Monday that he will return to the upper chamber this week after taking time off for the death of his daughter, Madison.   The Virginia senator wrote on the social platform X, "As we remember our incredible daughter, Maddy, my family has been deeply touched by the outpouring of support we've received. Thank you to everyone for your kind words." Madison Warner, 36, died earlier this month after a decades-long battle with juvenile diabetes and other health issues. Mark Warner and his wife, Lisa Collis, wrote in a statement last Monday that they were "heartbroken beyond words" by their daughter's passing.   On Monday, the former Virginia governor said his daughter "was a deeply empathetic and engaged person" and that "as recently as the day she passed, she was full of ideas and suggestions" for him, including how he could improve his social media presence.   "She used to say to me: 'Dad, you have the power — you have to use it.' She pushed me to make the most of my position, to use my seat in the Senate to help people in meaningful ways," he added.       "If I can find any solace during this time, it's that I have the enormous privilege to serve Virginians and the responsibility to keep working for a better, more just world in Maddy's name."   Warner concluded, "I look forward to returning to the Senate this week and continuing that essential work."   Madison Warner is survived by two younger sisters.     An estimated than 2.1 million Americans, including about 314,000 children and adolescents younger than age 20, have diagnosed type 1 diabetes as of March — which is what juvenile diabetes is commonly called — according to the CDC's National Diabetes Statistics Report.   An estimated 11 million U.S. adults have undiagnosed diabetes, the report notes.   Symptoms of type 1 diabetes include feeling more thirsty than usual, urinating a lot, bed-wetting in children who have never done so, feeling very hungry and losing weight without trying, according to the Mayo Clinic. https://thehill.com/homenews/senate/5851605-mark-warner-diabetes-death/ XX Mattel, Inc. and Breakthrough T1D just won a Gold Halo Award for Best Cause Product Initiative for the launch of the first Barbie with T1D.  The Halo Awards recognize the most outstanding corporate social impact efforts over the past year.

Host: Darryl S. Chutka, M.D.  Guest: Uma Thanarajasingham, M.D., Ph.D.  Systemic lupus is a chronic autoimmune disease with a variety of immunologic and laboratory abnormalities. It has numerous clinical manifestations potentially involving multiple organs. It's known as the great imitator because it can mimic a variety of other diseases, and it's not uncommon for patients to have symptoms for a number of years prior to a diagnosis being established. What symptoms should alert us to the possibility of lupus? What do we do with a low titer, positive ANA? How is a firm diagnosis established and what role does the primary care clinician play in the management of those with lupus? I'll be asking these questions and more of my guest, Dr. Uma Thanarajasingam from the Division of Rheumatology at the Mayo Clinic as we discuss “Lupus Today: Advances in Diagnosis and Treatment”.  Connect with us! Mayo Clinic Talks Podcast Season 6 | Mayo Clinic School of Continuous Professional Development 

In this episode of the HealthspanMD Podcast, Dr. Robert Todd Hurst, MD, FACC, FASE sits down with Dr. Selen Courtney to explore one of the most overlooked pillars of longevity: physical performance. They dive into how strength, stability, and functional movement play a critical role in preventing frailty, extending healthspan, and maintaining independence as we age. From understanding progressive overload and muscle failure to identifying hidden blind spots like power and balance, this episode offers a practical, science-backed roadmap to staying strong, resilient, and capable for life. Dr. Selen Courtney is a Doctor of Physical Therapy with a unique background in psychology, yoga, orthopedics, and leadership at the Mayo Clinic. Now at HealthspanMD, she focuses on shifting physical therapy from reactive injury care to proactive performance and prevention. Her work centers on helping individuals identify weaknesses early, optimize movement, and build the strength and stability needed to live longer, healthier lives. Key Timestamps 00:00 – Intro and why you don't need to train to full failure 01:00 – Why avoiding frailty is essential for longevity 02:20 – Dr. Selen Courtney's background and journey to HealthspanMD 04:40 – Rethinking physical therapy as prevention, not just rehab 06:30 – Why decline accelerates in your 60s and how to prevent it 08:00 – Muscle loss, injury, and the downward spiral of aging 09:20 – Inside the HealthspanMD physical performance assessment 11:30 – How strength, balance, and movement are objectively measured 13:50 – Why “average” isn't good enough for longevity 15:50 – Common fitness blind spots and imbalanced training 18:20 – Why people gravitate to what they like (and what they neglect) 20:30 – Fixing the reactive, one-size-fits-all fitness model 22:50 – What stability really means (rotator cuff, trunk endurance) 25:10 – Safe strength training principles for longevity 27:30 – Progressive overload and training close to failure explained 29:50 – The importance of protein and recovery for muscle growth 32:00 – Overtraining and why more is not always better 33:50 – What functional movement actually means in real life 34:40 – The physical performance age score explained 36:50 – How data reveals your biggest opportunities 37:00 – Technology used to measure strength, power, and balance 41:30 – The most overlooked blind spot: power training 43:50 – Final advice: start small and build consistency Connect with Dr. Selen Courtney:

When did you last think about what's living inside your walls? Right now, up to 70% of homes in the US have mold growing inside them, and most people have absolutely no idea. In fact, one study tested 160 homes across the country and found mold in every single one — yet only 17% of those homeowners thought they had a problem. And it's not just sinus issues. Mold exposure has been linked to brain fog, chronic fatigue, anxiety, memory loss, and immune issues — symptoms that send people to doctor after doctor with no real answers. The Mayo Clinic found that 93% of chronic sinus infections can be traced back to mold. What if there was an affordable, at-home kit that could detect 36 harmful mold species hiding in your household dust, one that matches the molds in your home to the mycotoxins in your body? Our guest, Brian Karr, is a Certified Mold Inspector, a second-generation indoor environmental consultant specializing in assisting hypersensitive individuals with complex medical conditions by identifying and addressing mold, mycotoxins, and other indoor pathogens in their homes, leading to significant improvements in their health. KEY TAKEAWAYS 1.    How VOCs and hidden mold exposure show up in a home that looks completely normal 2.    The biggest mistakes people make when testing their homes for mold, and what actually offers useful data 3.    Beyond mold, the byproducts that mold creates that impact our health 4.    Some of the most common health patterns that make people think, "this could be an environmental issue"? 5.    The biggest myths about mold or indoor air quality 6.    For listeners who suspect their home might be part of the problem—but feel overwhelmed—the first 1–2 practical steps to take è You can learn about The Dust Test at: https://www.thedusttest.com/ or https://yesweinspect.com/. Additionally, Brian shares knowledge through his popular podcast, #moldfinders: RADIO. è You can find the links in the show notes at Healthy Home Hacks. Be sure to leave a review or rating – five stars are always appreciated. And, if you're not already subscribed…consider this your friendly reminder.

In July 2025, 13-year-old Cody Trenkel Jr. set out on a routine skateboard ride through his grandmother's quiet Missouri neighborhood—and never made it to his destination. What began as a normal summer morning turned into a multi-day search across miles of wooded terrain, with no clear clues and time running out. As search teams struggled to narrow down where to look, one unexpected factor changed everything. This episode follows the critical decisions, the hidden dangers close to home, and the narrow window that can make the difference between life and death. 01:08 Podcast Intro 01:30 Meet Daryl The Bloodhound 03:29 How Cody Vanished 08:54 The Ravine Fall 10:34 Surviving Heat And Trauma 13:22 Three Day Search 15:21 Bloodhound Tracks The Trail 18:10 Rescue And ICU Fight 21:05 Recovery And Reunion 22:09 Other Bloodhound Saves 25:44 Prevention And Check Ins 29:58 First Aid If Found 33:35 Closing Reflections 35:37 Listener Outro SOURCES Neely, Shanie. "Paws to the Rescue: How a K-9 Helped Find a Missing Boy." Reader's Digest, April/May 2026. rd.com/article/dog-rescues-missing-boy/ "He's a Fighter: 13-Year-Old Missouri Teen Rescued Alive in Ravine After 76 Hours Missing." KSDK, July 31, 2025. ksdk.com "A Teen Missing for 3 Days Needed a Miracle — A Dog Came to the Rescue." WGRZ, September 2025. wgrz.com "Missing Boy Found in Missouri Ravine After 4 Days." KSDK, July 30, 2025. ksdk.com Holcombe, Madeline. "3-Year-Old Casey Hathaway Told Authorities a Bear Kept Him Company." CNN, January 29, 2019. cnn.com Heat Stroke. Mayo Clinic. mayoclinic.org Bloodhound Breed Information. American Kennel Club. akc.org Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

In this episode of the Chasing Giants Podcast, Terry and Don kick things off with an emotional and heartfelt update on Robin's health journey following their visit to the Mayo Clinic. Don shares the overwhelming support, prayers, and messages they've received—and the peace that has come with it as they prepare for surgery. This episode is a powerful reminder of faith, community, and the impact of prayer. From there, the conversation shifts into what Chasing Giants does best—real-world whitetail strategy. Don and Terry break down current spring food plot conditions, discuss planting timing, and explain how weather can completely change even the best-laid plans. They also dive into: - Corn vs. soybean planting timing strategy - How heavy rain can impact food plots - Why patience matters with soil temperature - Common mistakes land managers make - How to identify bad hunting advice online - The importance of sanctuaries and minimizing intrusion This episode blends real life, real hunting, and real strategy—exactly what the Chasing Giants audience expects. Sponsors: Asio Gear – https://asiogear.com Real World Wildlife Products – https://realworldwildlifeproducts.com Hawke Optics – https://us.hawkeoptics.com Novix Outdoors – https://novixoutdoors.com Midwest Land Group – https://midwestlandgroup.com 360 Hunting Blinds – https://360huntingblinds.com Mike's Mighty Micros – https://mikesmightymicros.com Gingerich Tree Farm – https://gingerichtreefarm.com TagOut Technique – https://tagouttechnique.com Grubb Implement – https://grubbimplement.com Brenton USA – https://brentonusa.com Mathews Archery – https://mathewsinc.com Victory Auto Group – https://victorykc.com Wildlife Farming – https://wildlifefarming.com WiseEye Technologies – https://wiseeyetech.com DISCLAIMER: The views and opinions expressed in this podcast are those of the hosts and guests and do not necessarily reflect the official policy or position of any sponsors or affiliated companies. © Chasing Giants. All rights reserved. This content may not be reproduced or distributed without written permission.

Congratulations to Logan Eury and his new wife Emily, got married today, May 1, 2026!  This C.O. Bigelow Collab Introduces the 188-Year-Old Pharmacy to a New Generation Abbode is taking over the Carolyn Bessette-Kennedy-approved shop for a month-long pop-up. https://fashionista.com/2026/05/co-bigelow-abbode-pop-up-carolyn-bessette-impact  The article highlights how a pop-up and renewed interest in C.O. Bigelow has been fueled by the cultural resurgence of Carolyn Bessette-Kennedy's minimalist style, amplified by media and social buzz. This renewed attention has driven significant foot traffic and sales, showing how storytelling, nostalgia, and “quiet luxury” aesthetics can translate into real retail impact.   Q&A: Mayo Clinic leaders share strategies for managing high-cost drugs without breaking the bank | Asembia AXS26 Summit https://www.managedhealthcareexecutive.com/view/q-a-mayo-clinic-leaders-share-strategies-for-managing-high-cost-drugs-without-breaking-the-bank-asembia-axs26-summit Mayo Clinic leaders emphasize that managing high-cost drugs requires clear definitions, structured formulary review processes, and multidisciplinary collaboration to balance cost, access, and clinical value. They highlight the importance of evaluating safety, efficacy, financial impact, and site-of-care decisions together, while noting that non-340B systems face increasing pressure from rising costs and reimbursement constraints. Ultimately, success depends on stronger alignment between health systems, manufacturers, and payers to sustain access without compromising quality of care.  Where Gross-to-net Pressure Actually Lives After Launch Today's guest post comes from Cindy Baksh, Chief Product Officer at ConnectiveRx. https://www.drugchannels.net/2026/05/where-gross-to-net-pressure-actually.html The article explains that “gross-to-net pressure” isn't driven by a single factor, but by a combination of rebates, discounts, fees, and policy changes that continue to reshape how drug pricing actually works behind the scenes. As the industry shifts toward a “net pricing” model, traditional rebate-driven strategies are weakening, forcing manufacturers, PBMs, and pharmacies to rethink how value and profits are generated. Today's featured guest is Dr. Ndidiamaka Okpareke PharmD for Congress Dr. Ndidiamaka “Didi” Okpareke, PharmD, is a pharmacist, entrepreneur, and political candidate running for Congress in New Mexico's 1st Congressional District. A first-generation Nigerian-American, she built her career in healthcare after graduating from the University of New Mexico College of Pharmacy and went on to found and lead a successful compounding pharmacy serving her community.  Motivated by nearly two decades of patient care experience, Okpareke entered the political arena to address challenges such as healthcare access, rising costs, and the shortage of providers in New Mexico. Running as a Republican, she emphasizes strengthening healthcare systems, supporting economic growth, and preserving opportunity for future generations, positioning herself as a community-focused leader bringing frontline healthcare insight into public policy.  This special episode highlights how TJM Labs is redefining pharmacy operations through AI-driven automation, bringing together insights from industry leaders Bhavesh Patel, PharmD—CEO of Carepoint Pharmacy—and Jonathan Adly, PharmD, MBA—CEO of TJM Labs. At the center of the conversation is how modern pharmacies are facing rising prescription volumes, staffing constraints, and increasing operational complexity, and why traditional manual workflows can no longer keep pace. TJM Labs addresses this challenge by deploying AI-powered “digital workers” that automate tasks like prescription intake, data entry, and patient communication—allowing pharmacy teams to shift their focus back to patient care and clinical decision-making.  Through the lens of both operator and innovator, the discussion explores how AI is not replacing pharmacy professionals, but augmenting them—reducing burnout, improving accuracy, and enabling scalable growth. With automation handling up to the majority of repetitive workload and delivering measurable ROI, TJM Labs represents a new model where technology and pharmacy expertise work together to create more efficient, patient-centered operations. 

Alan Mulally is one of the most effective leaders of his generation. He is the Former President and CEO of Ford Motor Company, where he led the company through an existential crisis and back to profitability. He was also CEO of the commercial airlines division at Boeing, where he led the development of the Boeing 777, the most profitable aircraft in the company's history. He is also on the Board of Directors at the Mayo Clinic, Google and several cutting edge startups. Alan joined host Robert Glazer on ⁠the Elevate Podcast⁠ to talk about his exemplary career, his model of leadership and management, how he led Ford from the brink of disaster, and much more. Check out the resources referenced in this episode ⁠at this link⁠. Thank you to the sponsors of The Elevate Podcast Shopify: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠shopify.com/elevate⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Masterclass: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠masterclass.com/elevate⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Framer: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠framer.com/elevate⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Indeed: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠indeed.com/elevate⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Notion: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠notion.com/elevate⁠⁠⁠ Blinkist: ⁠⁠⁠blinkist.com/elevate⁠⁠⁠ QuickBooks: ⁠⁠⁠quickbooks.com/billpay Learn more about your ad choices. Visit megaphone.fm/adchoices

Day Break | Power Plays: Money, Maps, and the Battle for America --- 00:00 - Monologue 19:04 – Dr. Sanjeev Kumar, Mayo Clinic–trained gynecologic oncologist. Dr. Kumar discusses his case and broader concerns about increasing pressure and scrutiny on physicians. He explains how regulatory and legal actions could impact patient care and the medical profession. 28:00 – Nick Hopwood, Certified Financial Planner and Founder of Peak Wealth Management. Hopwood breaks down the Fed's decision to hold interest rates steady and what it signals for the economy. He also discusses market trends, including seasonal patterns, long-term growth despite global instability, and the potential return of inflation. 38:07 - Monologue Featuring Ivey Gruber 47:04 – Dan McGroarty, Head Strategic Advisor at Graphite One. McGroarty discusses the growing importance of graphite in national security and defense, particularly in drone technology. He explains why securing domestic supply chains is becoming critical for the U.S. 57:08 – Marc Werner, CEO of GhostBed. Werner explains how poor sleep quality is often tied to mattress issues rather than aging. He discusses how proper support, alignment, and cooling technology can significantly improve sleep and overall health. Visit ghostbed.com/gruber and use code GRUBER for savings. 57:08 – Mark Vargas, GOP Media Surrogate and Editor-in-Chief of Illinois Review. Vargas discusses ongoing redistricting battles across the country. He also provides updates on energy markets and the latest developments involving Iran. 1:16:01 - Monologue 1:35:12 – Wendy Block, Senior VP of Business Advocacy for the Michigan Chamber. Block discusses opposition to a proposed constitutional convention in Michigan. She outlines concerns from the business community and directs listeners to michamber.com for more information. 1:44:01 – Ivey Gruber, President of the Michigan Talk Network. Gruber discusses concerns about government use of AI and technology in vehicles. The conversation focuses on potential risks to personal freedom and privacy. --- Check out our brand new podcast, 'Forgotten America'... The twelfth episode is live NOW at Steve Gruber on YouTube! Link below: https://youtu.be/1XbEJhJ6Wrk

Labia fillers are one of those beauty trends that's quietly gaining traction- and chances are, you didn't even know it was something you were supposed to think about.In this episode, I break down what labia fillers actually are, why more people are getting them, and the beauty standards driving the demand. We're getting into the language, the marketing, and the bigger cultural shift behind this idea of "rejuvenation." If you've ever wondered how far beauty standards can go, this episode might change the way you see them.Are. You. Ready?****************Sources & References:Braun, V. (2009). Female genital cosmetic surgery: A critical review. Feminism & Psychology, 19(2), 139–159.Gill, R. (2007). Gender and the Media. Polity Press.Illich, I. (1976). Limits to Medicine: Medical Nemesis: The Expropriation of Health. Pantheon Books.Bordo, S. (1993). Unbearable Weight: Feminism, Western Culture, and the BodyLiao, L. M., Creighton, S. M., & Crouch, N. S. (2005). Female genital appearance: “Normality” unfolds. BJOG: An International Journal of Obstetrics and Gynaecology, 112(5), 643–646.Tiefer, L. (2008). Female Sexual Dysfunction: A Case Study of Disease Mongering. PLoS Medicine, 5(2), e32.American Society of Plastic Surgeons. (2023). Cosmetic Procedure Trends Report.Royal College of Obstetricians and Gynaecologists. (2013). Ethical Considerations in Relation to Female Genital Cosmetic Surgery (FGCS).American Psychological Association. (2007). Report of the APA Task Force on the Sexualization of Girls.Smith, T. P. (2022). The Infantilization of Women and Pedophilic Beauty Standards in Western Culture: A Literature Review. Medium.Cleveland Clinic. (2023). Dermal Fillers: What to Know Before You Get Them.Mayo Clinic. (2023). Dermal Fillers Overview.****************Leave Us a 5* Rating, it helps the show!Apple Podcast:https://podcasts.apple.com/us/podcast/beauty-unlocked-the-podcast/id1522636282Spotify Podcast:https://open.spotify.com/show/37MLxC8eRob1D0ZcgcCorA****************Follow Us on TikTok & Subscribe to our YouTube Channel!YouTube:@beautyunlockedspodcasthourTikTok:tiktok.com/@beautyunlockedthepod****************Intro/Outro Music:“Fame Inc” by Savvier — https://icons8.com/music

Host: Darryl S. Chutka, M.D.  Guest: Carl H. Cramer, III, M.D.  Kidney transplantation has significantly improved the outlook for children with end-stage renal failure. The journey these children follow to transplantation starts in primary care with the recognition of chronic kidney disease, timely referral to nephrology, and long-term coordination of care with the transplant team. What are the most common health conditions which result in chronic kidney disease in children? What are some of the challenges faced in pediatric kidney transplantation and what do primary care clinicians need to know in caring for these children following kidney transplant? These are some of the questions I'll be asking my guest Dr. Carl Cramer, a pediatric nephrologist and specialist in pediatric renal transplantation at the Mayo Clinic as we discuss “Pediatric Kidney Transplant”.  Mayo Clinic Talks: Transplantation Series  Connect with us! Mayo Clinic Talks Podcast Season 6 | Mayo Clinic School of Continuous Professional Development 

Send us Fan MailDr. David Sas, pediatric nephrologist at Mayo Clinic, joins Ben to discuss primary hyperoxaluria type 1 — a rare but devastating genetic disease where the liver overproduces oxalate, flooding the kidneys with crystals and leading to end-stage kidney failure in roughly 60% of patients, historically requiring both a liver and kidney transplant. He presents 60-month long-term extension data on Lumasiran, an siRNA-based therapy that suppresses oxalate production at its source — showing that urinary oxalate drops rapidly within the first three months and stays down with quarterly injections, potentially changing the trajectory of this disease forever. He also issues a direct call to urologists and nephrologists everywhere: if your patient has recurrent calcium oxalate stones, check a 24-hour urine — because primary hyperoxaluria is almost certainly being missed.Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.Enjoy!

Send us Fan MailIn this episode of Skin Anarchy, Dr. Ekta Yadav sits down with Dr. Saranya Wyles of Mayo Clinic to unpack one of the most misunderstood areas in modern skincare: regenerative science. As “regenerative” becomes a buzzword, this conversation brings clarity—grounding the discussion in biology, not marketing.At its core, regeneration isn't about boosting collagen or improving texture. It's about restoring tissue structure and function—something the body does naturally, but imperfectly. Dr. Wyles reframes the space as a spectrum: from surgical grafting and platelet-rich plasma to newer acellular approaches like peptides and extracellular vesicles. What we call “regenerative skincare” today sits somewhere within that spectrum—but rarely at its most advanced end.The conversation extends to growth factors and peptides, where context matters just as much as inclusion. These signaling molecules play critical roles in repair, but their effectiveness depends on delivery, timing, and biological relevance—factors often overlooked in consumer formulations.Perhaps the most important distinction is between regeneration and longevity. One repairs damage; the other prevents it. Aligning skincare with that rhythm—protection by day, repair by night—creates a more biologically grounded approach.This episode challenges assumptions and sharpens perspective. Listen to the full episode to hear Dr. Wyles break down what regenerative skincare really means—and what it doesn't.Learn more about Dr. WylesDon't forget to subscribe to Skin Anarchy on Apple Podcasts, Spotify, or your preferred platform.Reach out to us through email with any questions.Sign up for our newsletter!Shop all our episodes and products mentioned through our ShopMy Shelf!Support the show