Podcasts about Mayo Clinic

Are your New Year's resolutions setting you up for success or just another cycle of diet culture? Before you jump into the latest trend, discover what nutrition recommendations actually work for lasting health. It's time to pull back the curtain on what's really required for sustainable habits in 2026.In this episode of Salad With a Side of Fries, host Jenn Trepeck is joined by Tara Schmidt, registered dietitian and Instructor of Nutrition at Mayo Clinic, to cut through the noise of fad diets and quick fixes. Together, they explore evidence-based nutrition, the truth about GLP-1 medications, why weight management shouldn't focus solely on the scale, and how to build lifestyle changes that actually last beyond January.What You Will Learn in This Episode:✅ Why your weight loss goals shouldn't focus on the number on the scale and what health metrics actually matter for long-term wellness and disease prevention✅ The truth about popular trends like 75 Hard, macro counting, low-carb diets, and GLP-1 medications—when they work, when they don't, and what's missing from the conversation✅ How to identify your personal barriers to change and create sustainable habits using the strategies that have worked for you in the past (hint: it's called the You Plan)✅ What longevity strategies and evidence-based nutrition principles you should actually focus on in 2026, including sleep, strength training, and nourishment over restrictionThe Salad With a Side of Fries podcast, hosted by Jenn Trepeck, explores real-life wellness and weight-loss topics, debunking myths, misinformation, and flawed science surrounding nutrition and the food industry. Let's dive into wellness and weight loss for real life, including drinking, eating out, and skipping the grocery store.TIMESTAMPS:00:00 Challenging diet culture in 2026 with Tara Schmidt from Mayo Clinic06:24 How growing up in the 90s diet culture shaped Tara's approach to nutrition recommendations and patient care08:34 Deconstructing weight bias in resolutions and why your weight is just a number, not a measure of health12:12 Truth bombs on popular trends: 75 Hard, low-carb diets, and macro counting—when they help and when they harm18:32 Tara's advice when someone isn't losing weight each week, and the important metrics22:11 Deep dive into GLP-1 medications: the tool versus magic pill debate and why lifestyle changes still matter28:38 Getting your nutrients from fruits, veggies and other supplements32:26 Where to start with health goals in 2026: asking better questions about what will make you feel better and longevity strategies that matter: sleep, strength training and mindfulness36:40 Planning for barriers and creating backup strategies so sustainable habits stick when life happens39:34 Why balance is a verb, not a destination, and how to keep adjusting your approach in real time41:00 Creating your personalized nutrition plan using what's worked for you beforeKEY TAKEAWAYS:

HAPPY HOLIDAYS! Enjoy this re-release from Season 3 of Mayo Clinic Talks: Host: Darryl S. Chutka, M.D.  Guest: Amy S. Oxentenko, M.D.   It's estimated that less than 1/3 of individuals with celiac disease have been properly diagnosed. When those with celiac disease ingest gluten, an immune response develops which attacks the small intestine leading to inadequate absorption of nutrients. If left untreated, celiac disease can lead to a variety of nutritional deficiencies as well as other serious consequences. Those with celiac disease are also at increased risk for coronary disease and small bowel cancers. In this podcast we'll review celiac disease and gluten sensitivity with our guest, Amy S. Oxentenko, M.D., a gastroenterologist at the Mayo Clinic. We'll discuss the symptoms of celiac disease, how to diagnose the condition and how patients with celiac disease should be managed.   Connect with us and learn more here: https://ce.mayo.edu/online-education/content/mayo-clinic-podcasts 

Anticoagulation Monotherapy in Patients with Chronic Coronary Artery Disease and Atrial Fibrillation   Guest: Keri Zieminski, APRN, C.N.P., D.N.P. Host: Sharonne Hayes, M.D.   This episode of Mayo Clinic's “Interviews With the Experts” will give an overview of anticoagulation monotherapy in patients with chronic CAD and atrial fibrillation. Discussion will include a brief overview of recently published trials that highlight the use of anticoagulation monotherapy in chronic CAD with atrial fibrillation, and how to manage a patient on anticoagulation monotherapy that needs to undergo noncardiac surgery.    Topics Discussed: Why has there been a shift towards redefining antithrombotic medical therapy in patients with chronic CAD with atrial fibrillation? What's changed? Recently published trials that highlight the use of anticoagulation monotherapy in the chronic CAD + AF population. What is your process for managing a patient on anticoagulation monotherapy that needs to go for noncardiac surgery?    Connect with Mayo Clinic's Cardiovascular Continuing Medical Education online at https://cveducation.mayo.edu or on Twitter @MayoClinicCV and @MayoCVservices. LinkedIn: Mayo Clinic Cardiovascular Services Cardiovascular Education App: The Mayo Clinic Cardiovascular CME App is an innovative educational platform that features cardiology-focused continuing medical education wherever and whenever you need it. Use this app to access other free content and browse upcoming courses. Download it for free in Apple or Google stores today! No CME credit offered for this episode.   Podcast episode transcript found here.

In this throwback Dental Hacks episode, I am joined by Dr. Jason Lipscomb to welcome two absolute legends in dental education: Dr. Frank Spear and Dr. Gregg Kinzer. This interview was originally released back in 2018 and it marked the first time Jason, Frank, and Gregg sat down together on the podcast, delivering a conversation packed with history, philosophy, and actionable practice management advice. The conversation traces the evolution of dental continuing education, moving from Frank's early days of disjointed lectures to the structured, curriculum-based approach of the Spear Center today. The group discusses the dynamics of Frank and Gregg's successful 20-year partnership, emphasizing the importance of shared vision over finding a "clone." They provide deep insights into patient communication, specifically how to filter new patients using the "Emergency Room vs. Mayo Clinic" analogy and how to re-engage long-time patients in comprehensive care without making them feel neglected. Finally, they cover the importance of fighting burnout through clinical growth and the future of restorative dentistry, including the integration of airway health and online team education. Some links from the show: Periowise Periodontal Probes Jason: BeadSmith 3mm Hooked Dimple Pliers Alan: Ugly Delicious Join the Very Dental Facebook Group using one of these passwords: Timmerman, Bioclear, Hornbrook, Gary, McWethy, Papa Randy, or Lipscomb!  The Very Dental Podcast network is and will remain free to download. If you'd like to support the shows you love at Very Dental then show a little love to the people that support us! I'm a big fan of the Bioclear Method! I think you should give it a try and I've got a great offer to help you get on board! Use the exclusive Very Dental Podcast code VERYDENTAL8TON for 15% OFF your total Bioclear purchase, including Core Anterior and Posterior Four day courses, Black Triangle Certification, and all Bioclear products. Crazy Dental has everything you need from cotton rolls to equipment and everything in between and the best prices you'll find anywhere! If you head over to verydentalpodcast.com/crazy and use coupon code "VERYSHIP" you'll get free shipping on your order! Go save yourself some money and support the show all at the same time! The Wonderist Agency is basically a one stop shop for marketing your practice and your brand. From logo redesign to a full service marketing plan, the folks at Wonderist have you covered! Go check them out at verydentalpodcast.com/wonderist! Enova Illumination makes the very best in loupes and headlights, including their new ergonomic angled prism loupes! They also distribute loupe mounted cameras and even the amazing line of Zumax microscopes! If you want to help out the podcast while upping your magnification and headlight game, you need to head over to verydentalpodcast.com/enova to see their whole line of products! CAD-Ray offers the best service on a wide variety of digital scanners, printers, mills and even  their very own browser based design software, Clinux! CAD-Ray has been a huge supporter of the Very Dental Podcast Network and I can tell you that you'll get no better service on everything digital dentistry than the folks from CAD-Ray. Go check them out at verydentalpodcast.com/CADRay!  

Today's guest is a true innovator at the intersection of health, science, longevity, and high performance. I'm honored to welcome Dr. Adrijana Kekic — a Mayo Clinic–trained clinical pharmacy and pharmacogenomics specialist, award-winning innovator, and Founder & CEO of Futurome, a precision health and longevity company built for high achievers. Known as a Longevity Pharmacist™, Dr. Kekic blends advanced multi-omics science — including genomics, proteomics, microbiome, and mitochondrial health — with deeply personalized protocols that go far beyond traditional labs or annual checkups. Her mission is bold and necessary: to help executives, founders, athletes, and legacy builders optimize their biology so they can extend both lifespan and healthspan with clarity and confidence. After years leading precision medicine initiatives at Mayo Clinic — and surviving a life-altering personal health crisis — Dr. Kekic realized modern medicine often waits until something breaks. She founded Futurome to change that paradigm, giving people actionable insights into their cellular biology before burnout, disease, or decline takes over. In this episode, we go deep on longevity, personalized medicine, high performance, and the future of health — and what it truly takes to sustain ambitious lives from the inside out. In this conversation, we explore: Dr. Kekic's journey from Mayo Clinic to founding Futurome — and the moment she knew precision health needed a new paradigm How her personal health crisis reshaped the way she listens to the body and practices medicine The meaning behind the name Futurome and the mission driving the company Multi-omics explained in simple terms — and why it's a game-changer Underrated biomarkers for longevity, resilience, and performance  The biggest blind spots high achievers have when it comes to their health Common misconceptions about aging that are holding people back The first three steps to start optimizing your biology today The role stress, sleep, and recovery play compared to genetics Where personalized health and longevity are headed in the next 5–10 years This episode is a must-listen if you care about living longer, stronger, clearer — and on your own terms.

HAPPY HOLIDAYS! Enjoy this re-release from Season 3 of Mayo Clinic Talks:   Host: Darryl S. Chutka M.D. Guest: Lisa Lammert, R.D.N., L.D.   Cardiovascular disease is the leading cause of death to individuals in the U.S. Many feel that our typical American diet with its high saturated fat content is a major contributor to this. There's good evidence that shows plant-based diets are cost-effective in lowering the risk factors for cardiovascular disease including obesity, hyperlipidemia, hypertension, and diabetes. They may also lower the number of medications an individual needs to take to manage their chronic diseases. So, are there any disadvantages to a plant-based diet? Are all plant-based diets healthy and what are the nutritional challenges for a patient on a plant-based diet? We'll discuss these questions in this podcast on “Plant-Based Diets”. Our guest is Lisa Lammert, a registered dietician and nutritionist at the Mayo Clinic.   Connect with us and learn more here: https://ce.mayo.edu/online-education/content/mayo-clinic-podcasts 

On this episode Fred Goldstein invites Sheena Crosby, PharmD, BCGP, Inflammatory Bowel Disease Clinical Pharmacist at the Mayo Clinic in Florida. Sheena breaks down the American College of Gastroenterology's (ACG) updated guidelines for ulcerative colitis and Crohn's disease, highlighting major shifts in treatment strategy, including the move toward earlier use of advanced therapies and updated goals focused on symptom control, mucosal healing, and sustained remission. She also outlines the critical payer considerations emphasized in the guidelines—from eliminating unnecessary step-therapy requirements to ensuring timely access to induction and maintenance therapy—changes that have direct implications for patient outcomes and health-system performance. Find all of our network podcasts on your favorite podcast platforms and be sure to subscribe and like us. Learn more at www.healthcarenowradio.com/listen/

Updated Guidelines for Perioperative Cardiovascular Management for Noncardiac Surgery   Guest: Michael Cullen, M.D. Host: Kyle Klarich, M.D.   This episode of Mayo Clinic's “Interviews With the Experts” reviews the assessment of patients with known or suspected cardiovascular disease undergoing noncardiac surgery.  Dr. Michael Cullen discusses recommendations from 2024 ACC/AHA perioperative guidelines regarding medication management before and after noncardiac surgery, including recommendations for antiplatelet therapy and bridging anticoagulation.  Finally, he highlights new recommendations in the recent 2024 ACC/AHA perioperative guidelines and compare these guidelines to the 2022 European Society of Cardiology perioperative guidelines.   Topics Discussed: How should clinicians approach the assessment of a patient prior to noncardiac surgery? How should physicians and APPs manage cardiac medications around the time of noncardiac surgery? What are some of the new recommendations in the 2024 ACC/AHA guidelines for perioperative management prior to noncardiac surgery? How do the 2024 ACC/AHA perioperative guidelines differ from the 2022 ESC noncardiac surgery guidelines?   Connect with Mayo Clinic's Cardiovascular Continuing Medical Education online at https://cveducation.mayo.edu or on Twitter @MayoClinicCV and @MayoCVservices. LinkedIn: Mayo Clinic Cardiovascular Services Cardiovascular Education App: The Mayo Clinic Cardiovascular CME App is an innovative educational platform that features cardiology-focused continuing medical education wherever and whenever you need it. Use this app to access other free content and browse upcoming courses. Download it for free in Apple or Google stores today! No CME credit offered for this episode.   Podcast episode transcript found here.

Jeff Adam explores the powerful link between oral health and overall wellness, citing Mayo Clinic findings that connect gum disease to serious systemic conditions. He also highlights the often-overlooked energetic relationship between teeth, organs, and the body's meridian system. Micronic Silver | Natural remedies holistic The post Jeff Adam appeared first on ABQ Connect.

Join us as we explore a critical question: What if the solution to America's number one killer isn't in the pharmacy, but in the kitchen? Today's guest is Dr. Elizabeth Klodas, a Mayo Clinic and Johns Hopkins-trained cardiologist who founded Step One Foods after realizing that doctors, including herself, weren't addressing the most powerful intervention for heart disease diet.Elizabeth Klodas, MD, Founder & Chief Medical Officer, Step One FoodsMegan Antonelli, Chief Executive Officer, HealthIMPACT Live

In today's episode of Beating Cancer Daily, Saranne unveils some essential travel secrets to help cancer patients manage jet lag. Drawing from her own experiences of traveling during her treatment for Stage IV cancer, Saranne shares practical strategies inspired by the Mayo Clinic and the New York Times. Listen in as she explains how to adjust sleep schedules, hydrate effectively, and use innovative apps to minimize the impact of time zone changes. Whether you're planning a trip or just curious about handling travel fatigue, join Saranne to explore these valuable tips and make your journeys smoother and more enjoyable.2025 People's Choice Podcast Awards Finalist Ranked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025, and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 Beating Cancer Daily is listened to in over 130 countries across 7 continents and features over 390 original daily episodes hosted by  Stage IV survivor Saranne Rothberg.   To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne Traveling Cancer Secrets

Welcome to The Mental Breakdown and Psychreg Podcast! Today, Dr. Berney and Dr. Marshall discuss the various factors that contribute to the development of our personality. Read the articles from the American Psychiatric Association here and from the Mayo Clinic here. You can now follow Dr. Marshall on twitter, as well! Dr. Berney and Dr. Marshall are happy to announce the release of their new parenting e-book, Handbook for Raising an Emotionally Healthy Child Part 2: Attention. You can get your copy from Amazon here. We hope that you will join us each morning so that we can help you make your day the best it can be! See you tomorrow. Become a patron and support our work at http://www.Patreon.com/thementalbreakdown. Visit Psychreg for blog posts covering a variety of topics within the fields of mental health and psychology. The Parenting Your ADHD Child course is now on YouTube! Check it out at the Paedeia YouTube Channel. The Handbook for Raising an Emotionally Health Child Part 1: Behavior Management is now available on kindle! Get your copy today! The Elimination Diet Manual is now available on kindle and nook! Get your copy today! Follow us on Twitter and Facebook and subscribe to our YouTube Channels, Paedeia and The Mental Breakdown. Please leave us a review on iTunes so that others might find our podcast and join in on the conversation!

This episode covers: • FDA Loosens Supplement Warning Labels The FDA is considering a rule change that would allow supplement companies to include the DSHEA disclaimer only once per package rather than next to every claim. Dave explains why fewer visible warnings could make marketing look more like medical claims, and why biohackers should treat labels as advertising rather than evidence. He shares how to protect yourself now: add one variable at a time, run baseline labs, and rely on data instead of packaging. Source: https://www.nbcnews.com/health/health-news/fda-supplements-warning-label-rule-change-rfk-jr-rcna249321 • Quantum Sensors for Early Heart Attack Detection Mayo Clinic is testing a contactless heart-monitoring system called CardiAQ using quantum magnetic sensors and AI noise filtering. The device reads subtle electromagnetic signatures from the heart and compares them to invasive angiography. Dave breaks down why earlier detection of ischemia could shift heart care from reactive treatment to proactive screening — and why building baseline metrics like VO₂max, blood pressure and HRV today will pay off when next-gen diagnostics arrive. Source: https://www.sandboxaq.com/press/sandboxaq-collaborates-with-mayo-clinic-on-novel-cardiac-diagnostics • Sauna Detox for MicroplasticsEmerging research shows that sweating meaningfully removes plastic-related chemicals like BPA and phthalate metabolites from the body, often more efficiently than blood or urine alone. Sauna use amplifies this effect by increasing circulation, mobilizing stored toxins from tissues, and accelerating sweat-based excretion. When you combine regular heat exposure with reduced environmental plastic contact, you create a powerful detox strategy that targets a chemical burden once thought unavoidable. Dave breaks down how sauna protocols can support toxin elimination, improve cardiovascular resilience, strengthen autonomic balance, and help counteract the metabolic and hormonal disruptions linked to microplastics in modern life.Source: https://superage.com/can-you-sweat-out-microplastics-in-the-sauna/ • Psychedelics and Longevity Biomarkers Bryan Johnson treated a guided psilocybin experience as a structured longevity experiment, collecting nearly 250 biomarkers including CGM, stress markers, HRV and Kernel brain imaging. The experiment revealed a surprising metabolic change: mean glucose dropped 8 percent, variability fell 11 percent, and estimated HbA1c moved from 4.7 to 4.4 — similar to months of metformin but after a single session. Dave explores the emerging idea that neuroplastic events might influence glucose regulation through brain-pancreas signaling, while emphasizing the need for supervised, legal use and proper clinical trials. Source: https://www.businessinsider.com/bryan-johnson-trip-on-mushrooms-five-hours-live-2025-12 • A Mitochondrial Protein that Extends Mouse Lifespan Researchers boosted the mitochondrial protein COX7RP and extended mouse lifespan by ~6.6 percent while improving insulin sensitivity, lipid handling, endurance and liver fat metabolism. COX7RP supports formation of mitochondrial “supercomplexes,” improving respiratory efficiency and ATP generation. Dave explains how this reinforces lifestyle levers — strength training, aerobic capacity, stabilizing blood sugar — as tools that likely preserve supercomplex architecture and mitochondrial resilience. Source: https://www.eurekalert.org/news-releases/1109082 All source links provided for direct access to the original research and reporting. This episode is designed for biohackers, longevity seekers and high-performance listeners who want practical strategies rooted in cutting-edge science. Dave Asprey translates emerging research into actionable upgrades for your biology — from metabolism and mitochondria to nervous system health, detox, and prevention. New episodes every Tuesday, Thursday, Friday, and Sunday. Keywords: FDA supplement rule change, supplement warning labels, DSHEA disclaimer removal, supplement regulation risks, quantum cardiac scanner, Mayo Clinic heart attack detection, AI heart monitoring, early ischemia detection technology, sauna detox evidence, sweating out toxins research, BPA phthalate sweat studies, microplastics sauna myth, Bryan Johnson psilocybin experiment, psychedelic longevity research, psychedelic metabolic reset, glucose control psychedelics, HbA1c psilocybin results, continuous glucose monitor insights, mitochondria lifespan research, COX7RP protein aging study, mitochondrial supercomplex benefits, ATP energy output aging, metabolic flexibility longevity, biohacking news update, anti-aging science breakthroughs, evidence-based longevity tools, biological age biomarkers Thank you to our sponsors! -BEYOND Conference 2026 | Register now at https://beyondconference.com/ -BodyGuardz | Visit https://www.bodyguardz.com/ and use code DAVE for 25% off. Resources: • Subscribe to my weekly newsletter: https://substack.daveasprey.com/welcome • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 - Intro 0:18 - Story 1: FDA Supplement Label Changes 1:43 - Story 2: CardiAQ Heart Scanner 2:59 - Story 3: Saunas and Microplastics 4:58 - Story 4: Psychedelics and Blood Sugar 8:22 - Story 5: Mitochondrial Longevity Research 10:29 - Weekly Wrap-Up See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Food as Medicine: Dr. Elizabeth Klodas – Disrupting Cardiology with Clinical Nutrition Join us as we explore a critical question: What if the solution to America's number one killer isn't in the pharmacy, but in the kitchen? Today's guest is Dr. Elizabeth Klodas, a Mayo Clinic and Johns Hopkins-trained cardiologist who founded Step One Foods after realizing that doctors, including herself, weren't addressing the most powerful intervention for heart disease diet. Find all of our network podcasts on your favorite podcast platforms and be sure to subscribe and like us. Learn more at www.healthcarenowradio.com/listen/

Host Lisa Salberg sits down with Mayo Clinic cardiologist Dr. Steve Ommen to reflect on a pivotal year in hypertrophic cardiomyopathy care. They discuss emerging therapies, clinical trial lessons, genetics, AI in medicine, and practical guidance for patients and families as the HCM landscape continues to evolve.   This conversation was recorded Dec. 19, 2025.

In this episode of “Answers From the Lab,” host Bobbi Pritt, M.D., chair of the Division of Clinical Microbiology at Mayo Clinic, welcomes William Morice II, M.D., Ph.D., president and CEO of Mayo Clinic Laboratories, to explore recent news updates and key advancements shaping the industry in 2025.Staying healthy during the holidays (00:18): Discover how to protect yourself and others as a new influenza strain, holiday gatherings, and increased travel raise the risk of spreading viruses. 2025 breakthroughs and trends (04:31): Learn more about the technologies, regulations, and innovation influencing the future of clinical diagnostics. Note: Information in this post was accurate at the time of its posting.Resources"Answers From the Lab” podcast: Innovations Set to Shape the Industry in 2025Dr. Morice shares trends and predictions for 2025Mayo Clinic Minute: How to prepare for the influenza seasonMayo Clinic Minute: Wash your hands for better healthVaccines and viruses: Protecting health across generations

In the hospital setting, neurologists may be responsible for managing common end-of-life symptoms. Comprehensive end-of-life care integrates knowledge of the biomedical aspects of disease with patients' values and preferences for care; psychosocial, cultural, and spiritual needs; and support for patients and their families. In this episode, Teshamae Monteith, MD, FAAN, speaks with Claudia Z. Chou, MD, author of the article "End-of-Life Care and Hospice" in the Continuum® December 2025 Neuropalliative Care issue. Dr. Monteith is the associate editor of Continuum® Audio and an associate professor of clinical neurology at the University of Miami Miller School of Medicine in Miami, Florida. Dr. Knox is an assistant professor of neurology and a consultant in the Division of Community Internal Medicine, Geriatrics and Palliative Care at Mayo Clinic in Rochester, Minnesota. Additional Resources Read the article: End-of-Life Care and Hospice Subscribe to Continuum®: shop.lww.com/Continuum Earn CME (available only to AAN members): continpub.com/AudioCME Continuum® Aloud (verbatim audio-book style recordings of articles available only to Continuum® subscribers): continpub.com/Aloud More about the American Academy of Neurology: aan.com Social Media facebook.com/continuumcme @ContinuumAAN Host: @headacheMD Full episode transcript available here Dr Jones: This is Dr Lyell Jones, Editor-in-Chief of Continuum. Thank you for listening to Continuum Audio. Be sure to visit the links in the episode notes for information about earning CME, subscribing to the journal, and exclusive access to interviews not featured on the podcast. Dr Monteith: This is Dr Teshamae Monteith. Today I'm interviewing Dr Claudia Chou about her article on end-of-life care and hospice, which is found in the December 2025 Continuum issue on neuropalliative care. Welcome to our podcast. How are you? Dr Chou: I'm doing well. Thank you for having me. This is really exciting to be here. Dr Monteith: Absolutely. So, why don't you introduce yourself to our audience? Dr Chou: Sure. My name is Claudia Chou. I am a full time hospice and palliative medicine physician at Mayo Clinic in Rochester. I'm trained in neurology, movement disorders, and hospice and palliative medicine. I'm also passionate about education, and I'm the program director for the Hospice and Palliative Medicine fellowship here. Dr Monteith: Cool. So just learning about your training, I kind of have an idea of how you got into this work, but why don't you tell me what inspired you to get into this area? Dr Chou: It was chance, actually. And really just good luck, being in the right place at the right time. I was in my residency and felt like I was missing something in my training. I was seeing these patients who were suffering strokes and had acute decline in functional status. We were seeing patients with new diagnosis of glioblastoma and knowing what that future looked like for them. And while I went into neurology because of a love of neuroscience, localizing the lesion, all of those things that we all love about neurology, I still felt like I didn't have the skill set to serve patients where they perhaps needed me the most in those difficult times where they were dealing with serious illness and functional decline. And so, the serendipitous thing was that I saw a grand rounds presentation by someone who works in neurology and palliative care for people with Parkinson's disease. And truly, it's not an exaggeration to say that by the end of that lecture, I said, I need to do palliative care, I need to rotate in this, I need to learn more. I think this is what I've been missing. And I had plans to practice both movement disorders neurology and palliative care, but I finished training in 2020… and that was not a long time ago. We can think of all the things that were going on, all the different global forces that were influencing our day-to-day decisions. And the way things worked out, staying in palliative care was really what my family and I needed. Dr Monteith: Wow, so that's really interesting. Must have been a great lecturer. Dr Chou: Yes, like one of the best.  Dr Monteith: So why don't you tell me about the objectives of your article? Dr Chou: The objectives may be to fill in some of the gaps in knowledge that may be present for the general neurologist. We learn so much in neurology training, so much about how to diagnose and treat diseases, and I think I would argue that this really is part and parcel of all we should be doing. We are the experts in these diseases, and just because we're shifting to end-of-life or transitioning to a different type of care doesn't mean that we back out of someone's care entirely or transition over to a hospice or palliative care expert. It is part of our job to be there and guide patients and their care partners through this next phase. You know, I'm not saying we all need to be hospice and palliative care experts, but we need to be able to take those first steps with patients and their care partners. And so, I think objectives are really to focus in on, what are those core pieces of knowledge for end-of-life care and understanding hospice so we can take those first steps with patients and their care partners? Dr Monteith: So, why don't you give us some of those essential points in your article? Dr Chou: Yeah. In one section of the article, I talk about common symptoms that someone might experience at the end of life and how we might manage those. These days, a lot of hospitals have order sets that talk us through those symptoms. We can check things off of a drop-down menu. And yet I think there's a little bit more nuance to that. There may be situations in which we would choose one medication over another. There may be medications that we've never really thought of in terms of symptom management before. Something that I learned in my hospice and palliative medicine fellowship was that haloperidol can be helpful for nausea. I know that's usually not one of our go-tos in neurology for any number of reasons. So, I think that extra knowledge can take us pretty far when we're managing end of life symptoms, particularly in the hospital setting. And then I think the other component is the hospice component. A lot of us may have not had experience talking about hospice, talking about what hospice can provide, and again, knowing how to take those first steps with patients. We may be referring to social work or palliative medicine to start those conversations. But again, I think this is something that's definitely learnable and something that should be part of our skill set in neurology. Dr Monteith: Great. And so, when you speak about symptom management and being more comfortable with the tools that we have, how can we be more efficient and more effective at that? Dr Chou: Think about what the common symptoms are at end of life. We may know this kind of intuitively, but what we commonly see are things like pain, nausea, dyspnea, anxiety, delirium or agitation. And so, I think having a little bit of a checklist in mind can be helpful. You know, how can I systematically think through a differential, almost, for why my patient might be uncomfortable? Why they might be restless? Have I thought through these different symptoms? Can I try a medication from my tool kit? See if that works, and if it does, we can continue on. If not, what's the next thing that I can pivot to? So, I think these are common skills for a little bit of a differential diagnosis, if you will, and how to work through these problems just with the end-of-life lens on it. Dr Monteith: So, are there any, like, validated tools or checklists that are freely available? Dr Chou: I don't think there's been anything particularly validated for end-of-life care in neurologic disease. And so, a lot of our treatments and our approaches are empiric, but I don't think there's been anything validated, per se. Dr Monteith: Great. So, why don't we talk a little bit about the approach to discussions on hospice? We all, as you kind of alluded to, want to be effective neurologists, care for our patients, but we sometimes deal with very debilitating diseases. And so, when we think that or suspect that our patient is kind of terminally ill, how do we approach that to our patients? Of course, our patients come from different backgrounds, different experiences. So, what is your approach? Dr Chou: So, when we talk about hospice and when a patient may be appropriate for hospice, we have to acknowledge that we think that they may be in the last six months of their disease. We as the neurologist are the experts in their disease and the best ones to weigh in on that prognosis. The patient and their care partners then have to accept that the type of care that hospice provides is what makes sense for them. Hospice focuses on comfort and treating a patient's comfort as the primary goal. Hospice is not as interested in treating cancer, say, to prolong life. Hospice is not as interested in life-prolonging measures and treatments that are not focused at comfort and quality of life. And so, when we have that alignment between our understanding of a patient's disease and their prognosis and the patient care partner's goal is to focus on comfort and quality of life above all else, that's when we have a patient who might be appropriate for hospice and ready to hear more about what that actually entails. Dr Monteith: And what are some, maybe, myths that neurologist healthcare professionals may have about hospice that you really want us to kind of have some clarity on? Dr Chou: That's a great question. What we often tell patients is that hospice's goal is to help patients live as well as possible in the time that they have left. Again, our primary objective is not life prolongation, but quality of life. Hospice's goal is also not to speed up or slow down the natural dying process. Sometimes we do get questions about that: can't you make this go faster or we're ready for the end. But really, we are there to help patients along the natural journey that their body is taking them on. And I think hospice care can actually be complex. In the inpatient setting, in particular in neurology, we may be seeing patients who have suffered large strokes and have perhaps only days to a few weeks of life left. But in the outpatient setting and in the home hospice setting, patients can be on hospice for many months, and so they will have new care needs, new urinary tract infections, sometimes new rashes, the need to change their insulin regimens around to avoid extremes of hyperglycemia or hypoglycemia. So, there is a lot of complexity in that care and a lot that can be wrapped up under that quality-of-life and comfort umbrella. Dr Monteith: And to get someone to hospice requires a bit of prognostication, right? Six months of prediction in terms of a terminal illness. I know there's some nuances to that. So how can you make us feel more comfortable about making the recommendations for hospice? Dr Chou: I think this is a big challenge in the field. We're normally guided by Medicare guidelines that say when a patient might be hospice-appropriate. And so, for a neurologic disease, this really only encompasses four conditions: ALS, stroke, coma, and Alzheimer's dementia. And we can think of all the other diseases that are not encompassed in those four. And so, I think we say that we paint the picture of what it means to have a prognosis of six months or less. So, from the neurologic side, that can be, what do you know about this disease and what end-stage might look like? What is the pattern of the patient's functional decline? What are they needing more help with? Are there other factors at play such as heart failure or COPD that may in and of themselves not be a qualifying diagnosis for hospice, but when it's taken together in the whole clinical picture, you have a patient who's very ill and one that you're worried may die in the next six months or less? Dr Monteith: Then you also had some nice charts on kind of disease-specific guidelines. Can you take us a little bit through that? Dr Chou: The article does contain tables about specific criteria that may qualify someone for hospice with these neurologic conditions. And they are pretty dense. I know they're a checklist of a lot of different things. And so, how we practice is by trying to refer patients to hospice based on those guidelines as much as possible and then using our own clinical judgment as well, what we have seen through taking care of patients through the years. So, again, really going back to that decline. What is making you feel uncomfortable about this patient's prognosis? What is making you feel like, gosh, this patient could be well supported by hospice, and they could have six months or less? So, all of that should go into your decision as well. And all of that should go into your discussion with the patient and their care partners. Dr Monteith: Yeah. And reading your article, what stood out was all the services that patients can receive under hospice. So, I think sometimes people think, okay, this is terminal illness, let's get to hospice for whatever reasons, but not necessarily all the lists and lists and lists of benefits of hospice. So, I don't know that everyone's aware of all those benefits. So, can you talk to us a little bit about that? Dr Chou: Yeah, I like that you brought that up because that's also something that I often say to patients and their care partners when we're talking about hospice. When the time is right for a patient to enroll in hospice, they should not feel like they're giving anything up. There should be no more clinical trial that they're hoping to chase down, and so they should just feel like they're gaining all of those good supports: care that comes to their home, a team that knows them well, someone that's available twenty-four hours a day by phone and can actually even come into the home setting if needed to help with symptom management. Hospice comes as well with the psychosocial supports for just coping with what dying looks like. We know that's not easy to be thinking about dying for oneself, or for a family member or care partner to be losing their loved one. So, all of those supports are built into hospice. I did want to make a distinction, too, that hospice does not provide custodial care, which I explain to patients as care of the body, those daily needs for bathing, dressing, eating, etc. Sometimes patients are interested in hospice because they're needing more help at home, and I have to tell them that unfortunately, our healthcare system is not built for that. And if that's the sole reason that someone is interested in hospice, we have to think about a different approach, because that is not part of the hospice benefit.  Dr Monteith: Thank you for that. And then I learned about concurrent care. So why don't you tell us a little bit about that? That's a little bit of a nuance, right? Dr Chou: Yeah, that is a little bit of a nuance. And so, typically when patients are enrolling in hospice, they are transitioning from care the way that it's normally conducted in our healthcare system. So, outpatient visits to all of the specialists and to their primary care providers, the chance to go to the ER or the ICU for higher levels of care. And yet there are a subset of patients who can still have all of those cares alongside hospice care. That really applies to two specific populations: veterans who are receiving care through the Veterans Administration, and then younger patients, so twenty six years old and less, can receive that care through, essentially, a pediatric carve out. Dr Monteith: Great. Well, I mean, you gave so much information in your article, so our listeners are going to have to read it. I don't want you to spill everything, but if you can just kind of give me a sense what you want a neurologist to take away from your article, I think that would be helpful. Dr Chou: I think what I want neurologist to take away is that, again, this is something that is part of what we do as neurologists. This is part of our skill set, and this is part of what it means to take good care of patients. I think what we do in this transition period from kind of usual cares, diagnosis, full treatment to end of life, really can have impact on patients and their care partners. It's not uncommon for me to hear from family members who have had another loved one go through hospice about how that experience was positive or negative. And so, we can think about the influence for years to come, even, because of how well we can handle these transitions. That really can be more than the patient in front of us in their journey. That is really important, but it can also have wide-reaching implications beyond that. Dr Monteith: Excellent. And I know we were talking earlier a little bit about your excitement with the field and where it's going. So why don't you share some of that excitement? Dr Chou: Yeah. And so, I think there is a lot still to come in the field of neuropalliative care, particularly from an evidence base. I know we talked a lot about the soft skills, about presence and communication, but we are clinicians at heart, and we need to practice from an evidence base. I know that's been harder in palliative care, but we have some international work groups that really are trying to come together, see what our approaches look like, see where standardization may need to happen or where our differences are actually our strength. I think there can be a lot of variability in what palliative care looks like. So, my hope is that evidence base is coming through these collaborations. I know it's hard to have a conversation these days without talking about artificial intelligence, but that is certainly a hope. When you look at morbidity, when you look at patients with these complicated disease courses, what is pointing you in the direction of, again, a prognosis of six months or less or a patient who may do better with this disease versus not? And so, I think there's a lot to come from the artificial intelligence and big data realm. For the trainees listening out there, there is no better time to be excited about neuropalliative care and to be thinking about neuropalliative care. I said that I stumbled upon this field, and hopefully someone is inspired as well by listening to these podcasts and reading Continuum to know what this field is really about. And so, it's been exponential growth since I joined this field. We have medical students now who want to come into neuropalliative care as a profession. We have clinicians who are directors of neuropalliative care at their institutions. We have an international neuropalliative care society and neuropalliative care at AAN. And I think we are moving closer to that dream for all of us, which is that patients living with serious neurologic illness can be supported throughout that journey. High-quality, evidence-based palliative care. We're not there yet, but I think it is a possibility that we reach that in my lifetime. Dr Monteith: Well, excellent. I look forward to maybe another revision of this article with some of that work incorporated. And it's been wonderful to talk to you and to reflect on how better to approach patients that are towards the end of life and to help them with that decision-making process. Thank you so much.  Dr Chou: Yeah, thank you for having me. And we're very excited about this issue. Dr Monteith: Today. I've been interviewing Dr Claudia Chou about her article on end-of-life care and hospice, which is found in the December 2025 Continuum issue on neuropalliative care. Be sure to check out Continuum Audio episodes from this and other issues, and thank you to our listeners for joining today. Dr Monteith: This is Dr Teshamae Monteith, Associate Editor of Continuum Audio. If you've enjoyed this episode, you'll love the journal, which is full of in-depth and clinically relevant information important for neurology practitioners. Use the link in the episode notes to learn more and subscribe. AAN members, you can get CME for listening to this interview by completing the evaluation at continpub.com/audioCME. Thank you for listening to Continuum Audio.

Host: Darryl S. Chutka, M.D. Guest: Cory Ingram, M.D. As primary care providers, we have the privilege of guiding our patients through their healthcare journey, healing their medical conditions, managing them through chronic illness and at times, assisting them through the final chapters of their life. The topic for today's podcast is “Hospice”, an important though often underutilized part of that journey. Hospice is not about giving up, it's about changing the direction and goal of our care from cure to comfort. It prioritizes quality of life and maintaining dignity for patients going through a very challenging period of their life. My guest is Cory Ingram, M.D., a family medicine and palliative care physician from the Mayo Clinic who has extensive experience and insight into this topic. He'll guide us through when we should consider hospice, who qualifies for hospice and the importance of good communication skills in helping patients and their families during this last period of their life. Connect with us and learn more here: https://ce.mayo.edu/online-education/content/mayo-clinic-podcasts 

In this episode our host Matt Lowe is joined on the podcast by Jessica Pelkowski, Liz Anderson and Stacia D'Angelo from Mayo Clinic in Jacksonville, Florida and Paulina Andujo, Leila Salhi and Tina Chang from Cedars Sinai in Los Angeles to discuss their involvement with Operation Walk International and the impact that orthopaedic medical missions has had not only on the communities they worked with, but also on each of them as participants.

Obesity, Hypertension, and Risk Factors in Terms of Prevention and Decreasing the Risk of HfpEF   Guest: Affan Irfan, M.D., Ph.D. Host: Stephen L. Kopecky, M.D.   HFpEF is a type of heart failure where the heart pumps normally but becomes stiff. This leads to fatigue, shortness of breath, and fluid retention. It is closely linked to obesity, hypertension, and metabolic disorders, with cases rising as these conditions become more common.   Topics Discussed: What is HFpEF and its risk factors? How common are obesity and hypertension, and how often do they lead to HFpEF? How do you diagnose HFpEF? How effective are weight loss, diet, and exercise in preventing HFpEF? What medical and public health strategies help reduce these risk factors and HFpEF cases?    Connect with Mayo Clinic's Cardiovascular Continuing Medical Education online at https://cveducation.mayo.edu or on Twitter @MayoClinicCV and @MayoCVservices. LinkedIn: Mayo Clinic Cardiovascular Services Cardiovascular Education App: The Mayo Clinic Cardiovascular CME App is an innovative educational platform that features cardiology-focused continuing medical education wherever and whenever you need it. Use this app to access other free content and browse upcoming courses. Download it for free in Apple or Google stores today! No CME credit offered for this episode.   Podcast episode transcript found here.

In episode 99 of the Summits Podcast, co-hosts Vince Todd, Jr. and Daniel Abdallah are joined by Andrew Peters, Team Heroes cyclist and Division Manager at Republic National Distributing Company. Tune in as Andrew shares about surviving brain cancer, leaning on faith and good health habits to get through hard times, and how he's giving back to others facing a similar battle.

In this insightful episode, Dr. Dave Chatterjee speaks with Greg Clark—longtime enterprise content management and cybersecurity leader—about a foundational but overlooked ingredient of AI success: information readiness. While organizations rush to implement artificial intelligence, many neglect the quality, governance, security, and contextual integrity of the data fueling these systems. As Clark notes, without clean, curated, and governed information, even the most advanced AI models will misfire—sometimes with damaging or legally significant consequences.Together, they explore why “garbage in, garbage out” is more relevant than ever in the AI era, especially as enterprises confront fragmented data, weak metadata, inconsistent governance, and high regulatory scrutiny. Dr. Chatterjee weaves in his Commitment–Preparedness–Discipline (CPD) governance framework, demonstrating why information readiness must be treated as a strategic capability, not a technical afterthought. The conversation illuminates how trust, data integrity, and responsible model oversight are emerging as competitive differentiators in the age of GenAI and agentic AI.Time Stamps00:49 — Dave introduces Greg Clark02:43 — Clark's 20+ year journey07:14 — Defining information readiness08:32 — Importance of understanding data09:58 — Data chaos and pitfalls12:00 — Trust erosion13:29 — Air Canada chatbot case16:22 — Auditability and explainability18:51 — CPD applied to AI governance20:43 — Operational maturity22:53 — JPMorgan's Responsible AI Council25:43 — Security as strategic capability27:35 — Zero trust and data protection30:32 — Mayo Clinic example31:25 — Metrics for buy-in32:50 — Destroy-your-business scenarios34:21 — Trust-first culture36:09 — Human-in-the-loop37:20 — GDPR case38:23 — Final reflectionsTo access and download the entire podcast summary with discussion highlights - https://www.dchatte.com/episode-97-ais-missing-puzzle-piece-why-information-readiness-determines-ai-success/Connect with Host Dr. Dave Chatterjee LinkedIn: https://www.linkedin.com/in/dchatte/ Website: https://dchatte.com/Books PublishedThe DeepFake ConspiracyCybersecurity Readiness: A Holistic and High-Performance ApproachArticles PublishedRamasastry, C. and Chatterjee, D. (2025). Trusona: Recruiting For The Hacker Mindset, Ivey Publishing, Oct 3, 2025.Chatterjee, D. and Leslie, A. (2024). “Ignorance is not bliss: A human-centered whole-of-enterprise approach to cybersecurity preparedness,” Business Horizons, Accepted on Oct 29, 2024.Isik, O., Chatterjee, D., and...

Co-hosts Ryan Piansky, a graduate student and patient advocate living with eosinophilic esophagitis (EoE) and eosinophilic asthma, and Holly Knotowicz, a speech-language pathologist living with EoE who serves on APFED's Health Sciences Advisory Council, interview Fei Li Kuang, MD, PhD, an allergist and immunologist, at Northwestern Medicine, about receiving two APFED HOPE on the Horizon Grants. Disclaimer: The information provided in this podcast is designed to support, not replace, the relationship between listeners and their healthcare providers. Opinions, information, and recommendations shared in this podcast are not a substitute for medical advice. Decisions related to medical care should be made with your healthcare provider. Opinions and views of guests and co-hosts are their own.   Key Takeaways: [:50] Co-host Ryan Piansky introduces this episode, brought to you thanks to the support of Education Partners GSK, Sanofi, Regeneron, and Takeda. Ryan introduces co-host Holly Knotowicz.   [1:14] Holly introduces today's topic, two APFED HOPE on the Horizon Pilot Grant Projects and today's guest, Fei Li Kuang, MD, PhD, an Assistant Professor in the Division of Allergy and Immunology at Northwestern University Feinberg School of Medicine in Chicago, Illinois.   [1:42] Dr. Kuang is a physician-scientist who takes care of patients with eosinophilic disorders and also performs laboratory research on these disorders in her lab, often using patient samples. Holly thanks Dr. Kuang for joining us.   [2:05] As a child, Dr. Kuang always wanted to be a scientist. She is so grateful to live out her childhood dream, and it's because of the amazing people who have supported her, most importantly, her parents.   [2:29] In graduate school, Dr. Kuang studied B cells. When she went on to do an allergy fellowship, she thought she would study B cells and care for patients with B cell problems. Instead, she fell in love with allergy and eosinophilic disorders.   [2:50] Dr. Kuang is here, in part, because of the different mentors she has had, and in large part, because of the patients she has met along the way.   [3:20] Dr. Kuang had the opportunity to work with Amy Klion at the NIH in a clinical trial to treat patients with a drug that gets rid of eosinophils. She says it was a dream come true after her training.   [4:02] She says she learned so much about eosinophils, their unusual biology, and the mystery behind what they are here for. She got hooked.   [4:15] Dr. Kuang thinks the patients you meet in a clinical trial in a special place like NIH occupy a space in your heart that makes you want to keep working on the subject area.   [4:34] Patients in a clinical trial have given up a bunch of their time to travel to Bethesda, Maryland. For the trial Dr. Kuang participated in as a Fellow, it was a good year of their time to come out and do it.   [4:47] Dr. Kuang felt there were so many interesting questions, from an intellectual point of view, but there was also a real need from patients with chronic conditions. It was a beautiful opportunity to marry scientists with physicians in training.   [5:36] Dr. Kuang shares some knowledge about eosinophils. They are white blood cells that are in all of us. They have little pink packages or granules that "jumped out" in the light microscope almost 200 years ago, when we first identified them.   [6:00] Dr. Kuang says that animals, dating back to reptiles, and different species of dolphins, all have eosinophils. A veterinary scientist, Dr. Nicole Stacy of the University of Florida, has taken photos of eosinophils from all these different species.   [6:21] They've been around for a long time. What are they good for? What we know is that they are associated with disease conditions, such as asthma and others, including leukemia. Those were the classic first studies of eosinophils.   [6:42] Now, we have a different mindset about eosinophils from work by the late James Lee at Mayo Clinic, Arizona.   [6:58] Dr. Kuang credits Dr. Lee with suggesting that eosinophils not just cause us problems but also help treat parasitic infections, maintain tissue homeostasis, help wound healing, and tissue repair. That's a new area we are beginning to appreciate.   [7:41] Dr. Kuang says we need to be open-minded that in some circumstances, eosinophils may be helpful or innocent. Now we have tools to start to understand some of that. We need to collect information from patients being treated with medicines.   [8:10] Ryan tells of being diagnosed as a kid. Doctors explained to him that eosinophils fight parasites, but in some people, they get confused and attack the esophagus. That's EoE. That was easy to understand, but he knew that the researchers knew more.   [8:53] Ryan is grateful to the patient population around eosinophilic esophagitis, and is proud of APFED's support of patients and caregivers with HOPE Grants. APFED has the HOPE on the Horizon Research Program, entirely funded by community donations.   [9:13] To date, APFED has directed more than $2 million toward eosinophilic disease research initiatives through various grant programs. As a patient advocacy organization, APFED works with fantastic researchers who submit innovative research ideas.   [9:32] These research ideas go through an extensive and competitive peer-review process, supported by researchers and clinicians in the APFED community.   [9:42] Today, we're going to discuss two different projects supported by HOPE Pilot Grants with Dr. Kuang.   [10:00] Dr. Kuang thinks there are two ways these grant programs are important to patients. One is advancing research by nurturing seedling investigators. Dr. Kuang got her first grant when she was a Fellow. It was an incredible opportunity.   [10:25] These grant programs also nurture seedling ideas that don't have enough evidence yet to garner the larger NIH grants, and so forth. There are other sources for grants: pharmaceutical companies. The grant programs are for seeds.   [10:49] Patients need to know that there are new things that are given some chance of being tested out. Research takes some time, and the FDA process of getting a drug approved is long.   [11:04] For the newly diagnosed patient, it can feel overwhelming. It feels like there's a loss of control. Sometimes, participating in something like APFED, being part of a community, gives back a sense of control that is lost when you're handed a diagnosis.   [11:45] For patients who have had it for a long time, when they participate in research and become engaged in organizations like APFED, they know they may not directly benefit today, they may benefit later, but they hope future patients will benefit.   [12:21] That gives them a sense of control and hope that things will be better for the next generation. We all want that, especially in medicine, in something that we don't have a very deep understanding of.   [12:58] Dr. Kuang received two HOPE Pilot Grants, one in 2018 and one in 2022. The first grant was awarded when she was a Fellow at the NIH.   [13:05] That first grant explored some effects of eosinophilic depletion of pathogenic lymphocytes in hypereosinophilic syndrome and overlaps with EGIDs. Ryan asks for a broad overview of that research.   [13:25] When Dr. Kuang was a Fellow at the NIH, they were doing a Phase 2 clinical trial, looking at "blowing up" eosinophils in patients who have a lot of them, hypereosinophilic syndrome patients.   [13:39] They included patients who had eosinophilic GI disease, often beyond the esophagus. They may have esophageal involvement, but sometimes their stomach is impacted, sometimes their large bowel is impacted, with related symptoms.   [13:57] What Dr. Kuang and the team noticed in the trial was that just within that little group of patients, there were people who did well, and people who did much better than before, but would have recurrent symptoms, and with no eosinophils in their GI tissues.    [14:16] The researchers wanted to know what was causing these problems for the patient. If you take eosinophils away, what other factors will impact the immune system of the patient, semi-long-term?   [14:32] Their focus was on these groups of patients who had different responses. They looked at the white blood cells that had been previously described as being the responsible, "bad" T cells that lead to eosinophils in the gut.   [14:49] They found that the patients who had recurrent flares of the disease had more of the bad T cells, and the patients who responded well and never complained again about symptoms did not.   [15:03] That allowed researchers to identify that there were subsets of patients with the disease that they were calling the same thing.   [15:18] Dr. Kuang says that work also led them to find that those cells were being reported in patients who had food allergies for which they needed an epinephrine auto-injector.   [15:27] The researchers were curious whether that was just a food allergy issue, or only applied if you had food allergies and eosinophilic GI disease. That HOPE project allowed them to do a pilot study to look at food allergy patients, too. They did, and published it.   [15:45] They published that in patients who have a food allergy and have these T cells, the insides of those cells make different messages for the immune system than the ones that the researchers had previously described.   [16:01] In looking for why there were differences in those responses, they accidentally found that there were differences inside these cells in a completely different disease, which also had these T cells.   [16:21] Dr. Kuang says that the finding was kind of a surprise. If they had found anything in the eosinophilic GI disease patients, that would have been good. They also looked at the epithelial cells and the structure of the GI lining.   [16:42] Even though there were no eosinophils in the GI lining in the patients who had been treated with a biologic that depleted eosinophils, their GI lining still looked like the GI lining of patients who had eosinophilic GI disease.   [16:55] Dr. Kuang asked what was creating those spots. Our gut lining sheds, so there should have been an opportunity for the GI lining to turn over and look new. Something was there, making signals to create these spots. They did a different publication on that.   [17:21] The data from the HOPE Pilot study allowed Dr. Kuang to apply for larger grants. It allowed her to propose to the company that made this drug, when they did the Phase 3 trial, to insert into that special study the study on eosinophilic GI disease.   [17:48] Do patients with eosinophilic GI disease do better or worse on this drug, and how do the T cells look in that trial? That HOPE Grant gave Dr. Kuang the data to ask the drug company to give her money to study it in an international cohort of patients.   [18:17] There were only 20 patients in that first NIH trial, who gave a year of their life, coming to NIH all the time. They continued to be in the study until the drug was approved for asthma.   [18:28] Dr. Kuang says the main reason the company did the Phase 3 trial, which is expensive, and the market share is not huge because it's a rare disease, is that two of the patients went to bat for this disease population.   [18:47] The two patients went and showed the business people what they looked like before, what the drug had done for them, and how their lives had changed. It wasn't the doctors or the great paper from the trial, but the patients who convinced the company.   [19:01] Dr. Kuang says she was so floored by that and moved by what they did for the community. She is grateful.   [19:24] Since the Phase 3 trial, Dr. Kuang and the other researchers realized they had not fully studied the eosinophils. They had studied them in part. They found differences in response. This inspired the second APFED HOPE Pilot Grant.   [21:19] In 2022, Dr. Kuang received a two-year APFED HOPE Pilot Grant to examine how blood eosinophils in Eosinophilic Gastrointestinal Diseases differ from those of other eosinophilic diseases and how T cells in EGIDs differ from those in food allergies.   [21:49] Dr. Kuang says normally, the biggest place of residence for eosinophils is the GI tract. That's where they are normally seen in people who do not have eosinophilic disorders.   [21:59] People who have eosinophilic disorders that attack other parts of the body, asthma, and rarely, the heart. Dr. Kuang was curious to know why one person and not the other?   [22:15] Patients who have eosinophilic GI disease often ask, How do you know this high level in the blood is not going to attack my heart or my lungs in the future? Dr. Kuang does not know.   [22:29] Dr. Kuang says, looking at the cohort at the NIH, that for many patients who have both GI organ involvement and some other space, when they first went to see a provider, their first complaint was a GI condition.   [22:54] If the doctor had only diagnosed a GI condition, nothing else, that would have been wrong. Those patients may not have been monitored as well. A third of the patients originally presented like that.   [23:11] What that meant was that we should be paying attention to patients who have GI disease who have lots of eosinophils in their blood. Moving forward, if there are new complaints, we need to investigate. We can't forget they have that.   [23:27] Dr. Kuang asks, Wouldn't it be great if we had a better tool than needing to wait? Wouldn't it be great if we had a biomarker that said the eosinophils have switched their target location and are going somewhere else?   [23:41] One way to do that is to take different groups of eosinophils and look for differences between those that never target the GI tract and those that do. In patients who have EoE, the eosinophils only target or cause problems in the esophagus.   [23:58] Are their eosinophils any different than those of a healthy person, with none of these conditions? That was the goal of that study.   [24:10] T cells are another type of white blood cell. They contain a memory of foreign things they have encountered, which allows them to glom onto flu, COVID, peanuts, pollen, that kind of thing. They remember.   [24:32] Dr. Kuang says they learned that T cells, at least in the mouse model, are required in the development of eosinophilic esophagitis. The mice in the old study, where mice were forced to develop EoE, did not get EoE if you removed their T cells.   [24:50] In the first APFED HOPE grant study, Dr. Kuang found T cells in the blood and tissue of both EGIDs and food allergy patients, but the insides of the T cells were different. The food allergy patients were children recruited by a pediatric allergist.   [25:19] In the second APFED HOPE grant study, at Northwestern, Dr. Kuang recruited her adult food allergy patients. That was a way to validate what they found in the first study and move further to better characterize those T cells in the two different diseases.   [25:47] Dr. Kuang says we're at a point where we've recruited a lot of people. She says it's amazing what people are willing to do. It's very humbling.   [26:06] Dr. Kuang's team in the lab is really great, too. To accommodate patients, they would see them after work, if that's what they had to do to isolate eosinophils. So they did that, and now they are in the process of analyzing that data. It's really exciting.   [26:28] What's exciting is that they are seeing results that show that eosinophilic GI disease patients have circulating eosinophils that are different from the eosinophils of people who don't have GI involvement, and from people who have EoE.   [26:46] The EoE patients have eosinophils different from those of healthy donors. Dr. Kuang says there's a lot of promise for perhaps unique signatures that could help define these conditions; maybe someday without biopsying, but that's a long time away.   [27:16] Dr. Kuang says they will focus on some candidate targets and try to recreate some of that in a dish with eosinophils from healthy people.   [27:26] What are the signals that lead eosinophils to do this, and can we translate that back to available drugs that target certain cytokines or other pathways, and maybe give some insight to develop drugs that target other pathways for these diseases?   [28:17] Ryan thinks it's exciting that this research is narrowing in on not only the different symptoms, but also how the eosinophils are acting differently in these populations.    [28:44] Dr. Kuang is super excited about this research. You could imagine that all eosinophils are the same, but you don't know until you look. When they looked, using the newest technology, they found there were differences.   [29:33] Dr. Kuang says it is thought that T cells respond to triggers. We don't think eosinophils have a memory for antigens. T cells do. That's one of their definitions. When T cells react to a trigger, they give out messages through cytokines or by delivery.   [30:20] Those are the messages that recruit eosinophils and other cells to come and stir up some trouble.   [30:28] In the mouse model, where you don't have the T cells, and you don't get eosinophilic esophagitis in the particular way they made it happen in a mouse, that middle messenger is gone, so the eosinophils don't know where to go.   [30:44] With drugs that take out eosinophils, you think that you've gotten rid of the cell that creates all the problems. It shouldn't matter what the message says because there's no cell there to cause the damage.   [30:58] What Dr. Kuang learned is that, at least in certain eosinophilic GI diseases, that's not true. You erase the eosinophils from the picture, but that message is still coming.   [31:10] Who's carrying out the orders? Or is that message maintaining the wall of epithelial cells in a certain way that we didn't appreciate because the eosinophils were also there?   [31:24] It's important to study both, because one is the messenger and the other is one of the actors. Whether all of the actions taken by eosinophils are bad, or maybe some of them were meant to be good, we have yet to learn.   [31:40] At the moment, we're using it as a marker for disease activity, and that may change in the future, as we learn more about the roles of these cells in the process.   [31:50] We have drugs now that target eosinophils and drugs that target T cells. Dr. Kuang thinks it's important to study both and to study the impact of these drugs on these cells.   [32:02] You could theoretically use these drugs to understand whether, if someone responds to it, what happens to these cells, and if someone doesn't respond to it, what happens to these cells, and how this disease manifests in this flavor of patients.   [32:54] Dr. Kuang says, Often in science, we take a model. We think this works this way. Then, if this works this way, we expect that if we remove this, these things should happen. We did that with the first clinical trial, with NIH patients.   [33:10] It didn't quite happen the way we thought, so we had to go looking for explanations. These were unusual setbacks. Sometimes you have unusual findings, like the food allergy part.   [33:24] When Dr. Kuang went to Northwestern, she saw different cohorts of patients than she saw at NIH. She saw people who were seen every day, which is a different spectrum than those who are selected to be enrolled in a study protocol at the NIH.   [33:42] That broadened her viewpoint. It's maybe not all food-triggered. They were seeing adults who'd never had food allergies or asthma their whole life, and they had eosinophilic esophagitis suddenly as a 50-year-old. There's a significant group of them.   [34:10] What Dr. Kuang learned and tries to be open-minded about is that where you train, what sorts of patients you see, really shape your viewpoint and thinking about the disease process and the management process.   [34:24] Dr. Kuang says she was so lucky to have experienced that at a quaternary care referral center like the NIH and at an academic center like Northwestern, where there are fantastic gastroenterologists who see so many of these patients.   [34:56] Dr. Kuang and an Allergy Fellow knew they were going to get a wonderful data set from the NIH patients they had recruited, so they thought they had better look deeply at what had been learned before with older technology, with mice and people.   [35:13] They decided to gather previous research, and that ultimately got published as an article. From that research, they learned that people did things in many different ways because there was no standard. They didn't know what the standard should be.   [35:28] Different things you do to try to get eosinophils out of tissue impact how they look, in terms of transcript, gene expression, and what messages they make to define themselves as an eosinophil.   [35:43] They also learned that because eosinophils are hard to work with, they die easily, and you can't freeze them and work on them the next day; you can introduce issues in there that have to be accounted for.   [35:59] They learned that as an eosinophil research community, they ought to come up with some standards so that they can compare future studies with each other. Dr. Kuang says it was impossible to compare the old studies that used different premises.   [36:50] Dr. Kuang says we need to be proactive in creating the datasets in a standard way so that we can compare and have a more fruitful and diverse community of data. It's hard to use the old data.   [37:57] Dr. Kuang says they get fresh blood from patients, and because eosinophils are finicky, they need to be analyzed within four hours, or preserved in a way to save whatever fragile molecules are to be studied.   [38:19] If you let it sit, it starts dying, so you won't have as many of them, and they start changing because they're not in the body. Dr. Kuang experimented with putting a tube of blood on the bench and checking it with the same test every two hours. It changes.   [38:38] Four hours is a standard to prevent the eosinophils from dying. Patients need treatment. If a patient is hospitalized and needs treatment, Dr. Kuang's team needs to be there to get a sample before treatment is started.   [39:03] The treatment impacts it, changing the situation. Much of the treatment, initially, is steroids. When you give lots of steroids, the eosinophils go away. It's no good to draw their blood then.   [39:27] Dr. Kuang also gets a urine sample. The granules of the eosinophils can get into the urine. As they study people with active disease, they want to capture granule proteins in the urine as a less invasive way to monitor activity in different disease states.   [40:04] The patient just needs to give Dr. Kuang either arm and a urine sample.   [41:04] Dr. Kuang explains, you can count your eosinophils after four hours, but to study them, they have different flags of different colors and shapes. Those colors and shapes may mean that it's an activated eosinophil, or they may have other meanings.   [41:41] Dr. Kuang focused on markers that look at whether it's going to spill its granules and some traditional markers of activation.     [41:50] Everyone chooses a different marker of activation. So they decided to look at as many as they could. One marker is not sufficient. They seem to be different in different conditions. The markers are on the surface; you need to analyze them right away.   [42:20] Then, Dr. Kuang breaks open the eosinophils and grabs the messenger RNA. They preserve it to do sequencing to read out the orders to see what this eosinophil is telling itself to make. RNA chops up messages.   [43:00] When you open an eosinophil, a protein you find is RNA, which chops up messages, destroying parts of the cell. You want to save the message. There's a brief time to analyze the eosinophil. Dr. Kuang works to preserve and read the message.   [44:04] Dr. Kuang hopes someday to run a tube of blood, look at the flags on the eosinophils, and say, "I think your eosinophilic GI disease is active," or "You have a kind of eosinophilic GI disease we need to monitor more frequently for organ damage."   [44:38] If another patient doesn't have those flags, Dr. Kuang could say, "I think the chances that you're going to have involvement elsewhere are low." That can give reassurance to folks who are worried.   [45:15] Dr. Kuang hopes that someday we can understand better why some people have food allergies vs. eosinophilic GI disease. They both have T cells, but the T cells have different packages inside with messages to deliver.   [45:34] Every day, Dr. Kuang has to tell patients she doesn't have that answer. Someday, she hopes she can tell a patient she does have that answer.   [46:35] Dr. Kuang tells about an NIH grant she's excited about and the patients she recruits after therapy, or elimination diets, to examine eosinophils and T cells, to see the impacts their treatments or diets have had on eosinophilic GI disease.   [47:18] Dr. Kuang believes there will be predictors of who will respond to an elimination diet and who will respond to steroid therapy. She hopes one day to have that, rather than going through rounds of six to eight weeks followed by a scope.   [47:34] If you have an elimination diet for six to eight weeks, every time you add back a food, you have to do a scope. Dr. Kuang says it would be great if you could be more precise ahead of time for therapy.   [47:48] Dr. Kuang says these wonderful drugs selectively take out parts of the pathway in the immune system. They provide real-life opportunities to ask, why is this important in human biology and the human immune system?   [48:15] Dr. Kuang finds the knowledge itself fascinating and useful. She hopes it informs how we choose future drugs or therapeutic avenues to get the best we can out of what we've learned, so we have more targeted ways of treating specific diseases.   [48:48] Ryan is grateful for all the research happening for the eosinophilic disease community and all the patients participating in the research. He asks Dr. Kuang how a patient can participate in research.   [49:12] There are lots of ways to be involved in research. Dr. Kuang says her patients come away from participating in research feeling good about having done it.   [49:22] Answer a survey, if that's what you have bandwidth for. Where therapies are changing, being a part of a community is good for the community, for the future, but it's good for you, too. It's healing in ways that are not steroids or biologics.   [49:58] Being part of a community is healing in ways we all need when we feel alone and bewildered. You're not alone.   [50:12] There are many ways to participate: APFED, CEGIR, individual institutions, and clinical trials. They all have different amounts of involvement. It's worthwhile to participate, not only for future patients but for yourself. They're fantastic!   [50:56] Dr. Kuang talks about the privilege as a physician of working with APFED and other organizations to do this work.   [51:09] Holly thanks Dr. Kuang for sharing all of this research and exciting information.   [51:25] Dr. Kuang is excited about what her group is doing and is hopeful. Besides showing up for this disease, we have to show up for research, in general, in this country. It's a dark time for NIH research funding.   [51:55] Dr. Kuang asks the young listeners who are thinking of choosing a field to see the potential and get into it, study this, and believe that there's going to be a future with a more nurturing research environment.   [52:36] Dr. Kuang would hate to lose generations of scientists. She says that once she was a little girl who was trying to be a scientist. Her parents had no connections with scientists or doctors, but she was able to get into research, and she thinks you can, too.   [53:48] As a graduate student, Ryan has always been interested in trying to improve things, and he sees hope on the horizon. He's very grateful to the APFED community for supporting these research HOPE Pilot Grants.   [54:17] Ryan is very grateful to Dr. Kuang for joining us today.   [54:22] For our listeners who want to learn more about eosinophilic disorders, we encourage you to visit apfed.org and check out the links in the show notes.   [54:28] If you're looking to find a specialist who treats eosinophilic disorders, we encourage you to use APFED's Specialist Finder at apfed.org/specialist.   [54:37] If you'd like to connect with others impacted by eosinophilic diseases, please join APFED's online community on the Inspire Network at apfed.org/connections.   [54:57] Dr. Kuang thanks Ryan and Holly and says she enjoyed the conversation. Holly also thanks APFED's Education Partners GSK, Sanofi, Regeneron, and Takeda for supporting this episode.   Mentioned in This Episode: Fei Li Kuang, MD, PhD, Allergist and Immunologist, Northwestern Medicine   Grants and publications discussed: Apfed.org/blog/apfed-announces-2018-hope-apfed-hope-pilot-grant-recipient/ Apfed.org/blog/fei-li-kuang-hope-pilot-grant-award/  Pubmed.ncbi.nlm.nih.gov/39213186/ Pubmed.ncbi.nlm.nih.gov/37487654/   APFED on YouTube, Twitter, Facebook, Pinterest, Instagram Real Talk: Eosinophilic Diseases Podcast apfed.org/specialist apfed.org/connections apfed.org/research/clinical-trials   Education Partners: This episode of APFED's podcast is brought to you thanks to the support of GSK, Sanofi, Regeneron, and Takeda.   Tweetables:   "I think the patients that you meet in a clinical trial, especially in a special place like NIH, occupy a space in your heart — I don't mean to be all too emotional about this — that makes you want to keep working on the subject area." — Fei Li Kuang, MD, PhD   "When I was a Fellow at the NIH, we were doing a Phase 2 clinical trial, looking at, for want of a better word, "blowing up" eosinophils in patients who have a lot of them, hypereosinophilic syndrome patients." — Fei Li Kuang, MD, PhD   "We're at a point where we've recruited a lot of people. I've had patients drive from the northern part of Illinois … come down and give me blood. It's amazing what people want to do and are willing to do. It's very humbling, actually." — Fei Li Kuang, MD, PhD   "You erase the eosinophils from the picture, but that message is still coming. Who's carrying out the orders? Or is that message maintaining the wall of epithelial cells in a certain way that we didn't appreciate because the eosinophils were also there?" — Fei Li Kuang, MD, PhD   "We need to be proactive in creating the datasets in a standard way so that we can compare and have a more fruitful and diverse community of data." — Fei Li Kuang, MD, PhD   "I think it's worthwhile to participate [in a clinical trial], not only for the future people but for yourself." — Fei Li Kuang, MD, PhD   Guest Bio: Fei Li Kuang, MD, PhD, is currently an Assistant Professor in the Division of Allergy and Immunology at Northwestern University Feinberg School of Medicine in Chicago, IL. She is a graduate of the Albert Einstein College of Medicine Medical Scientist Training Program with both a PhD in Cell Biology/Immunology and an MD.  She completed her Internal Medicine Residency at Columbia University, New York Presbyterian Hospital in New York City, she did her Fellowship in Allergy and Immunology at the National Institute of Allergy and Infectious Disease (NIAID) in Bethesda, Maryland. She is a physician-scientist who takes care of patients with eosinophilic disorders and also performs laboratory research on these disorders in her lab, often using patient samples.

In the comedy business, it's easy to cancel one gig for another, better paying gig. Many times entertainers are looking at the short-term gain of making more money, instead of keeping their word. Here's a quick story about how keeping my word paid off BIG.  https://www.TheWorkLady.com  Jan McInnis is a top change management keynote speaker, comedian, and funny motivational speaker who helps organizations use humor to handle change, build resilience, and strengthen leadership skills. With her laugh-out-loud stories and practical tips, Jan shows audiences how humor isn't just entertainment—it's a business skill that drives communication, connection, and stress relief.   A conference keynote speaker, Master of Ceremonies, and comedy writer, Jan has written material for The Tonight Show with Jay Leno as well as radio, TV, and syndicated cartoon strips. She's the author of two books—Finding the Funny Fast and Convention Comedian—and her insights on humor in business have been featured in The Wall Street Journal, The Washington Post, and The Huffington Post. For over 25 years, she has been helping leaders and teams discover how to bounce back from setbacks, embrace change, and connect through comedy.   Jan has delivered keynote speeches at thousands of events nationwide, from the Federal Reserve Banks to the Mayo Clinic, for industries that include healthcare, finance, government, education, women's leadership events, technology, and safety & disaster management. Her client list features respected organizations such as: Healthcare: Mayo Clinic, Kaiser Permanente, Abbott Pharmaceuticals, Health Information Management Associations, Assisted Living Associations Finance: Federal Reserve Banks, Merrill Lynch, Transamerica Insurance, BDO Accounting, American Institute of CPAs, credit unions, banking associations Government: U.S. Air Force, Social Security Administration, International Institute of Municipal Clerks, National League of Cities, public utilities, correctional associations Women's Leadership Events: Toyota Women's Conference, Go Red for Women, Speaking of Women's Health, Soroptimists, Women in Insurance & Financial Services Education: State superintendent associations, community college associations, Head Start associations, National Association of Elementary and Middle School Principals Safety & Disaster: International Association of Emergency Managers, Disney Emergency Management, Mid-Atlantic Safety Conference, risk management associations   Her background as a Washington, D.C. marketing executive gives her a unique perspective that blends business acumen with stand-up comedy. Jan was also honored with the Greater Washington Society of Association Executives "Excellence in Education" Award. Along with her podcast Finding the Funny: Leadership Tips from a Comedian, Jan also produces Comedian Stories: Tales From the Road in Under 5 Minutes. Whether she's headlining a major convention, hosting a leadership retreat, or teaching resilience at a safety conference, Jan's programs give audiences the tools to laugh, learn, and lead.  

Welcome back to our BTK/ASGBI Series! During this series, BTK fellow Agnes Premkumar and ASGBI hosts Jared Wohlgemut and Gita Lingam compare and contrast various aspects of surgery between the United States and the United Kingdom, debating who does what better.  We are happy to be continuing our AI discussion further with another episode. While last episode lay a foundation on discussing the unique differences in the role and regulation of AI in both these countries, now we delve into some of the clinical challenges. What does AI and the future of surgery look like in underserved locations such as the battlefield or the rural communities. What does this mean for our future as surgeons…will we be replaced? And how should we address the integration of AI within our practices?  We are thrilled to have our trio of experts discussing this further. Dr. Nelson is a surgical oncologist working at the Brook Army Medical Center in San Antonio, he's very interested in expanding the role of AI within surgical education and beyond. Dr. Larson is a general surgery resident at the Mayo Clinic. She's currently in her research time and finishing up her master's degree in AI and studying the role of machine learning within surgical practice. Dr. Mukherjee is a surgeon scientist alongside an Honorary Consultant General & Major Trauma Surgeon in Liverpool, England. His current research bridges academia with industry and is aimed at transforming the treatment of critical illness through the development of next-generation therapies for pancreatitis-induced acute lung injury through the utilisation of cutting-edge AI driven drug discovery approaches.  Take a listen and let us know what you think!  References: Johns' Hopkins Ex-Vivo Cholecystectomy by a Robot https://hub.jhu.edu/2025/07/09/robot-performs-first-realistic-surgery-without-human-help/ Please visit https://behindtheknife.org to access other high-yield surgical education podcasts, videos and more.  If you liked this episode, check out our recent episodes here: https://behindtheknife.org/listen Behind the Knife Premium: General Surgery Oral Board Review Course: https://behindtheknife.org/premium/general-surgery-oral-board-review Trauma Surgery Video Atlas: https://behindtheknife.org/premium/trauma-surgery-video-atlas Dominate Surgery: A High-Yield Guide to Your Surgery Clerkship: https://behindtheknife.org/premium/dominate-surgery-a-high-yield-guide-to-your-surgery-clerkship Dominate Surgery for APPs: A High-Yield Guide to Your Surgery Rotation: https://behindtheknife.org/premium/dominate-surgery-for-apps-a-high-yield-guide-to-your-surgery-rotation Vascular Surgery Oral Board Review Course: https://behindtheknife.org/premium/vascular-surgery-oral-board-audio-review Colorectal Surgery Oral Board Review Course: https://behindtheknife.org/premium/colorectal-surgery-oral-board-audio-review Surgical Oncology Oral Board Review Course: https://behindtheknife.org/premium/surgical-oncology-oral-board-audio-review Cardiothoracic Oral Board Review Course: https://behindtheknife.org/premium/cardiothoracic-surgery-oral-board-audio-review Download our App: Apple App Store: https://apps.apple.com/us/app/behind-the-knife/id1672420049 Android/Google Play: https://play.google.com/store/apps/details?id=com.btk.app&hl=en_US

In this episode of the Optimal Body Podcast, Doc Jen and Doctor Dom, both Doctors of Physical Therapy chat with neuroscientist Ariel Garten, co-founder of Muse. Together, they explore how brainwave-sensing technology can make meditation more effective, support stress reduction, and improve sleep and pain management. Ariel shares practical tips for building healthy habits, explains the science behind meditation and brain health, and highlights Muse's research-backed benefits for women's wellness, including how it can improve sleep quality. The conversation is both empowering and approachable, offering actionable insights for women seeking to enhance their mental and physical well-being through mindful routines and innovative tools that can also help improve sleep.Needed Discount:Jen trusted Needed Supplements for fertility, pregnancy, and beyond! Support men and women's health with vitamins, Omega-3, and more. Used by 6,000+ pros. Use code OPTIMAL for 20% off at checkout!Muse Discount:Interested in what Muse can do for you? This tool has been shown to reduce stress, improve sleep and increase performance across multiple aspects of brain health. Check it out HERE and get a special 15% discount!Dr. Mina's Resources:Muse WebsiteMuse on IGMuse YoutubeMuse FacebookMuse DiscountWe think you'll love:Free Week of Jen HealthJen's InstagramDom's InstagramYouTube ChannelWhat You'll Learn from Ariel:04:44 Ariel explains brainwaves, how they're measured, and their significance in understanding brain activity.06:59 Discussion on how brainwave patterns relate to anxiety, depression, and brain region activity.09:35 How meditation and technology like Muse can influence brainwaves for better sleep and focus.11:57 Evidence for meditation's benefits, optimal durations, and Mayo Clinic...For full show notes and resources visit https://jen.health/podcast/439 Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

In this special series on Metabolic-Dysfunction Associated Steatotic Liver Disease (MASLD) and Metabolic Dysfunction-associated steatohepatitis (MASH) our host, Dr. Neil Skolnik will discuss Epidemiology, Importance, Screening, Diagnosis and Treatment of MASH. This special episode is supported by an independent educational grant from Boehringer Ingelheim. Presented by: Neil Skolnik, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Associate Director, Family Medicine Residency Program, Abington Jefferson Health Alina M. Allen, M.D. Associate Professor of Medicine at Mayo Clinic in Rochester, Minnesota, where she serves as the Director of Hepatology and Director of the MASLD Clinic. Selected references: Metabolic Dysfunction–Associated Steatotic Liver Disease (MASLD) in People With Diabetes: The Need for Screening and Early Intervention. A Consensus Report of the American Diabetes Association. Diabetes Care 2025;48(7):1057–1082

Dr. Benjamin Ritter, is an award-winning leadership and career coach, author of the Amazon best-seller Becoming Fearless, and founder of Live for Yourself (LFY) Consulting. He spreads the message of becoming fearless in your career and life as a Top LinkedIn Voice, and host of two podcasts, The Executive and Live Fearlessly.Ben has coached over 500 leaders with a strong focus on senior-level executives across multiple industries and geographic regions, within organizations that have included names such as Amazon, Coursera, DoorDash, Google, Fiserv, Northwestern, Mayo Clinic, Pinterest, Yelp, and more.Ben's passions include working with Better for You CPG organizations, small business founders and minority-owned companies, for which he offers pro-bono coaching services.Born and raised in Chicago, Illinois, Ben now resides in Austin, Texas, with his partner, Tiffany, Squirt, a “rebel in a shell” turtle, Elwood, a scruffy rescue pup, and Sima, the kitty queen of their kingdom.Ben possesses a Doctorate in Organizational Leadership with focus on value congruence and job satisfaction, an MBA in entrepreneurial management, and an MPH in health policy administration.Buy Ben's book Becoming Fearless here: https://amzn.to/3XR7YyQSupport the show.If you'd like to support the show, you can now buy mea coffee, beer, or whatever you'd like. Click here: ⁠ https://www.buymeacoffee.com/sundaylunchpm⁠You should soon be able to grab a copy of my booksand my guests' books here soon ⁠https://www.nigelcreaser.com/amazonshopAffilliatesOnline PM Courses: https://www.nigelcreaser.com/onlinepmcoursesSocial Media Channels:LinkedIn: https://www.linkedin.com/in/drbenjaminritter-leadershipdevelopment/YouTube: https://www.youtube.com/@DrBenjaminRitterInstagram: https://www.instagram.com/drbenjaminritterWebsite: https://www.liveforyourselfconsulting.com/Podcast: https://podcasts.apple.com/us/podcast/live-for-yourself-revolution-podcast-living-toward/id1151625064https://podcasts.apple.com/us/podcast/the-executive-podcast/id1588458800

This is the 69th episode in my drug pronunciation series. In this episode, I divide Kisunla and donanemab-azbt into syllables, tell you which syllables to emphasize, and share my sources. The written pronunciations are below and in the show notes on https://www.thepharmacistsvoice.com. Special thanks to Megan Hull, PharmD for inspiring me to pick Kisunla for this series. She mentioned it during the CE session she led at the Midyear Meeting of the Ohio Pharmacists Association in Nov 2025.   Note: we don't cover pharmacology in this series. Just pronunciations.   ⭐️Sign up for The Pharmacist's Voice ® monthly email newsletter! https://bit.ly/3AHJIaF ⭐️   Kisunla = kih-SUHN-lah kih, like kiss SUHN, like sunshine lah, like lullaby Emphasize SUHN Written pronunciation source: Medication Guide for Kisunla on https://kisunla.lilly.com/ (accessed 12-10-25). Spoken pronunciation example: Patient testimonial video https://kisunla.lilly.com/patient-stories (accessed 12-10-25).   Donanemab-azbt = doe-NAN-e-mab A-Z-B-T doe, as in a female deer NAN, like the woman's name, Nancy e, which is a short "E" sound or a schwa "E" sound mab, which is the stem (or suffix) for a monoclonal antibody Emphasize NAN Written pronunciation sources: USP Dictionary Online and medlineplus.gov. (accessed 12-10-25)  Spoken pronunciation example by Ronald Petersen MD, PhD YouTube video on Mayo Clinic's YouTube Channel (accessed 12-10-25)   If you know someone who would like to learn how to say Kisunla and donanemab-azbt, please share this episode with them. Subscribe for all future episodes. This podcast is on all major podcast players and YouTube. Popular links are below. ⬇️   Apple Podcasts   https://apple.co/42yqXOG  Spotify  https://spoti.fi/3qAk3uY  Amazon/Audible  https://adbl.co/43tM45P YouTube https://bit.ly/43Rnrjt   Host Background: Kim Newlove has been an Ohio pharmacist since 2001 (BS Pharm, Chem Minor). Her experience includes hospital, retail, compounding, and behavioral health. She is also an author, voice actor (medical narrator and audiobook narrator), podcast host, and consultant (audio production and podcasting).    Other episodes in this series The Pharmacist's Voice Podcast Episode 358, Pronunciation Series Episode 68 (Journavx) The Pharmacist's Voice Podcast Episode 356, Pronunciation Series Episode 67 (Zanaflex) The Pharmacist's Voice Podcast Episode 352, Pronunciation Series Episode 66 (Yescarta) The Pharmacist's Voice Podcast Episode 350, Pronunciation Series Episode 65 (Xarelto) The Pharmacist's Voice Podcast Episode 349, Pronunciation Series Episode 64 (acetaminophen) The Pharmacist's Voice Podcast Episode 348, Pronunciation Series Episode 63 (Welchol/colesevelam) The Pharmacist's Voice Podcast Episode 346, Pronunciation Series Episode 62 (valacyclovir) The Pharmacist's Voice Podcast Episode 343, Pronunciation Series Episode 61 (ubrogepant) The Pharmacist's Voice Podcast Episode 341, Pronunciation Series Episode 60 (topiramate) The Pharmacist's Voice Podcast Episode 339, Pronunciation Series Episode 59 (Suboxone) The Pharmacist's Voice Podcast Episode 337, Pronunciation Series Episode 58 (rosuvastatin)  The Pharmacist's Voice Podcast Episode 335, Pronunciation Series Episode 57 (QVAR) The Pharmacist's Voice Podcast Episode 333, Pronunciation Series Episode 56 (pantoprazole)  The Pharmacist's Voice Podcast Episode 330, Pronunciation Series Episode 55 (oxcarbazepine) The Pharmacist's Voice Podcast Episode 328, Pronunciation Series Episode 54 (nalmefene) The Pharmacist's Voice Podcast Episode 326, Pronunciation Series Episode 53 (Myrbetriq) The Pharmacist's Voice Podcast Episode 324, Pronunciation Series Episode 52 (liraglutide)  The Pharmacist's Voice Podcast Episode 322, Pronunciation Series Episode 51 (ketamine) The Pharmacist's Voice Podcast Episode 320, Pronunciation Series Episode 50 (Jantoven) The Pharmacist's Voice Podcast Episode 318, Pronunciation Series Episode 49 (ipratropium) The Pharmacist's Voice Podcast Episode 316, Pronunciation Series Episode 48 (hyoscyamine) The Pharmacist's Voice Podcast Episode 313, Pronunciation Series Episode 47 (guaifenesin) The Pharmacist's Voice Podcast Episode 311, Pronunciation Series Episode 46 (fluticasone) The Pharmacist's Voice Podcast Episode 309, Pronunciation Series Episode 45 (empagliflozin) The Pharmacist's Voice Podcast Episode 307, Pronunciation Series Episode 44 (dapagliflozin) The Pharmacist's Voice Podcast Episode 304, Pronunciation Series Episode 43 (cetirizine)  The Pharmacist's Voice Podcast Episode 302, Pronunciation Series Episode 42 (buspirone)  The Pharmacist's Voice Podcast Episode 301, Pronunciation Series Episode 41 (azithromycin) The Pharmacist's Voice Podcast Episode 298, Pronunciation Series Episode 40 (umeclidinium) The Pharmacist's Voice Podcast Episode 296, Pronunciation Series Episode 39 (Januvia)  The Pharmacist's Voice Podcast Episode 294, Pronunciation Series Episode 38 (Yasmin) The Pharmacist's Voice Podcast Episode 292, Pronunciation Series Episode 37 (Xanax, alprazolam) The Pharmacist's Voice Podcast Episode 290, Pronunciation Series Episode 36 (quetiapine)  The Pharmacist's Voice Podcast Episode 287, pronunciation series ep 35 (bupropion) The Pharmacist's Voice Podcast Episode 285, pronunciation series ep 34 (fentanyl) The Pharmacist's Voice Podcast Ep 281, Pronunciation Series Ep 33 levothyroxine (Synthroid) The Pharmacist's Voice ® Podcast Ep 278, Pronunciation Series Ep 32 ondansetron (Zofran) The Pharmacist's Voice ® Podcast Episode 276, pronunciation series episode 31 (tocilizumab-aazg) The Pharmacist's Voice ® Podcast Episode 274, pronunciation series episode 30 (citalopram and escitalopram) The Pharmacist's Voice ® Podcast Episode 272, pronunciation series episode 29 (losartan) The Pharmacist's Voice Podcast Episode 269, pronunciation series episode 28 (tirzepatide) The Pharmacist's Voice Podcast Episode 267, pronunciation series episode 27 (atorvastatin)  The Pharmacist's Voice Podcast Episode 265, pronunciation series episode 26 (omeprazole) The Pharmacist's Voice Podcast Episode 263, pronunciation series episode 25 (PDE-5 inhibitors) The Pharmacist's Voice Podcast Episode 259, pronunciation series episode 24 (ketorolac) The Pharmacist's Voice ® Podcast episode 254, pronunciation series episode 23 (Paxlovid) The Pharmacist's Voice ® Podcast episode 250, pronunciation series episode 22 (metformin/Glucophage) The Pharmacist's Voice Podcast ® episode 245, pronunciation series episode 21 (naltrexone/Vivitrol) The Pharmacist's Voice ® Podcast episode 240, pronunciation series episode 20 (levalbuterol) The Pharmacist's Voice ® Podcast episode 236, pronunciation series episode 19 (phentermine)  The Pharmacist's Voice ® Podcast episode 228, pronunciation series episode 18 (ezetimibe) The Pharmacist's Voice ® Podcast episode 219, pronunciation series episode 17 (semaglutide) The Pharmacist's Voice ® Podcast episode 215, pronunciation series episode 16 (mifepristone and misoprostol) The Pharmacist's Voice ® Podcast episode 211, pronunciation series episode 15 (Humira®) The Pharmacist's Voice ® Podcast episode 202, pronunciation series episode 14 (SMZ-TMP) The Pharmacist's Voice ® Podcast episode 198, pronunciation series episode 13 (carisoprodol) The Pharmacist's Voice ® Podcast episode 194, pronunciation series episode 12 (tianeptine) The Pharmacist's Voice ® Podcast episode 188, pronunciation series episode 11 (insulin icodec)  The Pharmacist's Voice ® Podcast episode 184, pronunciation series episode 10 (phenytoin and isotretinoin) The Pharmacist's Voice ® Podcast episode 180, pronunciation series episode 9 Apretude® (cabotegravir) The Pharmacist's Voice ® Podcast episode 177, pronunciation series episode 8 (metoprolol)  The Pharmacist's Voice ® Podcast episode 164, pronunciation series episode 7 (levetiracetam) The Pharmacist's Voice ® Podcast episode 159, pronunciation series episode 6 (talimogene laherparepvec or T-VEC)  The Pharmacist's Voice ® Podcast episode 155, pronunciation series episode 5 Trulicity® (dulaglutide)  The Pharmacist's Voice ® Podcast episode 148, pronunciation series episode 4 Besponsa® (inotuzumab ozogamicin) The Pharmacist's Voice ® Podcast episode 142, pronunciation series episode 3 Zolmitriptan and Zokinvy The Pharmacist's Voice ® Podcast episode 138, pronunciation series episode 2 Molnupiravir and Taltz The Pharmacist's Voice ® Podcast episode 134, pronunciation series episode 1 Eszopiclone and Qulipta   Kim's websites and social media links: ✅ Guest Application Form (The Pharmacist's Voice Podcast) https://bit.ly/41iGogX ✅ Monthly email newsletter sign-up link https://bit.ly/3AHJIaF  ✅ LinkedIn Newsletter link https://bit.ly/40VmV5B ✅ Business website https://www.thepharmacistsvoice.com ✅ Get my FREE eBook and audiobook about podcasting ✅ The Pharmacist's Voice ® Podcast https://www.thepharmacistsvoice.com/podcast ✅ Drug pronunciation course https://www.kimnewlove.com  ✅ Podcasting course https://www.kimnewlove.com/podcasting  ✅ LinkedIn https://www.linkedin.com/in/kimnewlove ✅ Facebook https://www.facebook.com/kim.newlove.96 ✅ Twitter https://twitter.com/KimNewloveVO ✅ Instagram https://www.instagram.com/kimnewlovevo/ ✅ YouTube https://www.youtube.com/channel/UCA3UyhNBi9CCqIMP8t1wRZQ ✅ ACX (Audiobook Narrator Profile) https://www.acx.com/narrator?p=A10FSORRTANJ4Z ✅ Start a podcast with my coach, Dave Jackson from The School of Podcasting! *New 12-4-25* Click my affiliate link: https://community.schoolofpodcasting.com/invitation?code=G43D3G    Thank you for listening to episode 360 of The Pharmacist's Voice ® Podcast.  If you know someone who would like this episode, please share it with them!

Welcome back to our BTK/ASGBI Series! During this series, BTK fellow Agnes Premkumar and ASGBI hosts Jared Wohlgemut and Gita Lingam compare and contrast various aspects of surgery between the United States and the United Kingdom, debating who does what better.  In this episode, we delve into all things artificial intelligence (AI) within surgery. Both the US and the UK have unique approaches to managing AI within healthcare and our experts help break down these key similarities and differences. We will discuss what AI and machine learning means, what does regulation look like in both these regions, and how is AI being used in both these countries.  We are fortunate to have two representatives, Dr. Nelson and Dr. Larson, representing the US side. Dr. Nelson is a surgical oncologist working at the Brook Army Medical Center in San Antonio, he's very interested in expanding the role of AI within surgical education and beyond. Dr. Larson is a general surgery resident at the Mayo Clinic. She's currently in her research time and finishing up her master's degree in AI and studying the role of machine learning within surgical practice. We are fortunate to have Dr. Mukherjee representing the UK side. Dr. Mukherjee is a surgeon scientist alongside an Honorary Consultant General & Major Trauma Surgeon in Liverpool, England. He has a strong track record in research that spans the translational spectrum, with strengths in discovery science related to acute pancreatitis pathophysiology and mitochondrial injury, novel in vitro and in vivo experimental assay development and clinical translational research, including novel biomarker studies and clinical trials. He has won multiple awards, most recently the Hunterian Professorship 2024 from the Royal College of Surgeons of England. Take a listen and let us know what you think- what do you think is the best way to promote and regulate AI within healthcare?  Please visit https://behindtheknife.org to access other high-yield surgical education podcasts, videos and more.   If you liked this episode, check out our recent episodes here: https://behindtheknife.org/listen Behind the Knife Premium: General Surgery Oral Board Review Course: https://behindtheknife.org/premium/general-surgery-oral-board-review Trauma Surgery Video Atlas: https://behindtheknife.org/premium/trauma-surgery-video-atlas Dominate Surgery: A High-Yield Guide to Your Surgery Clerkship: https://behindtheknife.org/premium/dominate-surgery-a-high-yield-guide-to-your-surgery-clerkship Dominate Surgery for APPs: A High-Yield Guide to Your Surgery Rotation: https://behindtheknife.org/premium/dominate-surgery-for-apps-a-high-yield-guide-to-your-surgery-rotation Vascular Surgery Oral Board Review Course: https://behindtheknife.org/premium/vascular-surgery-oral-board-audio-review Colorectal Surgery Oral Board Review Course: https://behindtheknife.org/premium/colorectal-surgery-oral-board-audio-review Surgical Oncology Oral Board Review Course: https://behindtheknife.org/premium/surgical-oncology-oral-board-audio-review Cardiothoracic Oral Board Review Course: https://behindtheknife.org/premium/cardiothoracic-surgery-oral-board-audio-review Download our App: Apple App Store: https://apps.apple.com/us/app/behind-the-knife/id1672420049 Android/Google Play: https://play.google.com/store/apps/details?id=com.btk.app&hl=en_US

In this episode, host David Mandell welcomes Dr. Paul Lynch, a double board-certified anesthesiologist and pain management specialist, entrepreneur, and business leader. Dr. Lynch shares his remarkable journey from aspiring psychiatrist to pain medicine innovator—a shift inspired by his mother-in-law's battle with cancer and the discovery of interventional pain treatments that could transform patients' lives. His early experiences at the Mayo Clinic shaped his belief in comprehensive, integrated care—a philosophy that became the foundation for his first practice, Arizona Pain, which quickly became one of the nation's leading pain management centers. Dr. Lynch details how entrepreneurial thinking, coupled with strategic use of digital tools, drove his success. His story of launching a medical website during fellowship—eventually ranking number one on Google before opening his doors—illustrates how physicians can use education-based marketing to reach patients and grow responsibly. As his career evolved, Dr. Lynch founded U.S. Pain Care, intentionally designed to avoid the mistakes of his first venture. Through introspection and what he calls his "Manifesto of 53 Errors," he now builds companies around lessons learned, focusing on empowering other physicians with ownership, autonomy, and ethical profitability. The discussion also delves into real estate, private equity, and long-term business strategy in medicine. Dr. Lynch explains how owning medical real estate can be one of the most impactful and ethical ways for physicians to build wealth—separate from clinical care—highlighting the benefits of property ownership, long-term leasing, and physician-owned REITs. He closes with advice to doctors: never make fortunes "on the backs of patients." Instead, focus on providing excellent care while building wealth through smart business decisions, integrity, and surrounding yourself with expert advisors in law, finance, and real estate. Learn more, including additional show notes, links, and detailed key takeaways, by visiting physicianswealthpodcast.com. Click here to get your FREE copy of our latest book, Wealth Strategies for Today's Physician!

Last month the Food and Drug Administration announced that it would remove its warning on hormone-based products used to treat menopause symptoms.  As women age, most will experience changes linked to the stop of their monthly menses, including hot flashes, bone density loss and sleep problems. But in the past two decades a strong “black-box warning” has scared many women off from seeking relief in hormone creams, patches, pills and other treatments. The warning was added following a landmark study that linked hormone therapy to an increased risk for cancer and cardiovascular problems. Now the FDA says the risks were overblown for most women. MPR News guest host Catharine Richert talks about the FDA's change, the risks and benefits of hormone therapy and what women should consider as they decide whether to try it. Guest: Dr. Jissy Cyriac is a primary care physician trained in internal medicine. She sees patients at the Menopause and Women's Sexual Health Clinic at Mayo Clinic in Rochester and is also a certified practitioner through The Menopause Society.  

Host: Darryl S. Chutka, M.D. Guest: Andrew R. Jagim, Ph.D. Nutritional supplements are very popular with our patients. They are supposed to provide benefits that may not be present in our typical diet. Vitamins and minerals are the most common supplements taken, followed closely by sports nutrition products such as protein powders and energy drinks. Consumers buy supplements because they're readily available, relatively low cost and they believe that supplements will help them achieve health benefits. Patients often assume that supplements are safe, yet some can cause significant health problems, especially when taken in higher doses. Some have the potential to interact with various prescription medications. Are there nutritional supplements our patients should be taking? Which ones are potentially harmful? How safe are these products and do supplements have any regulatory oversight? These are questions I'll be asking my guest, Andrew R. Jagim, Ph.D., Director of Sports Medicine Research at the Mayo Clinic as we discuss “Nutritional Supplements”. Connect with us and learn more here: https://ce.mayo.edu/online-education/content/mayo-clinic-podcasts 

At a recent Crain's event, hospital CEOs warned of fraying health care safety nets in the year ahead. Crain's health care reporter Jon Asplund talks with host Amy Guth about where local health care leaders say they are planning their focus in the year ahead.Plus: Feds warn CTA to boost policing or lose transit funding, Mars wins unconditional EU nod for $36B Kellanova deal, United Airlines CEO Kirby nets nearly $13M in first big stock sale and GE HealthCare touts slate of new tech plus collaboration with Mayo Clinic. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

The lung Composite Allocation Score (CAS) was implemented in 2023, and has shown to increase lung transplant rates and lower waitlist mortality. Host Alice Gallo de Moraes, MD, of the Mayo Clinic, interviews experts Mary Raddawi, MD, of Columbia University Irving Medical Center, and Amy Skiba, of the Lung Transplant Foundation, on the importance of CAS and how it has changed outcomes for lung transplant patients. 

Have the shorter, darker days of fall and winter ever left you feeling sluggish, down, or simply "blah"? Today, we are discussing seasonal affective disorder with Craig Sawchuk, PhD, LP, a clinical psychologist at Mayo Clinic. He details how the seasonal pattern often presents as "hibernation syndrome"; explores the characteristics that increase vulnerability to SAD; and covers the effective and unique evidence-based treatment for SAD: bright light therapy.

Sean Cassidy, CEO and Co-Founder of Lucem Health, is applying AI to identify patients at high risk of undiagnosed conditions like cancer and diabetes.  The goal is to facilitate earlier diagnosis and treatment by flagging patients that need screening based on the AI plaform's ability to analyze EHR data and demographics of diverse patient populations to ensure broad scalability. This technology was designed to integrate into existing clinical workflows for established screening procedures rather than making direct treatment recommendations.  Sean explains, "The origin of the company, the idea for the company, originated within Mayo Clinic in about 2020. Mayo Clinic has faced a challenge, and I think sometimes continues to face a challenge that a lot of researchers in AI have faced, which is how do you get promising AI in a clinical context from the so-called bench to the bedside? How do you get it from the lab into clinical practice? And what they realized was that while the data science and the AI part of it is really interesting, what was needed was scaffolding around the AI to facilitate integration with data and integration with workflows, a measurement and monitoring system, and so on and so forth." "We are trying to facilitate, and you're going to see us begin to expand the aperture, if you like, or open the aperture of how we position the company. Because as we've gone on, we have realized that the opportunity here is to actually help healthcare provider organizations, health systems, and so on, create really high-impact care delivery programs that have at their core or feature at their core earlier diagnosis, accelerated treatment, earlier treatment and therefore better outcomes for patients and hopefully even saved lives. So that's the generic approach that we take."  #LucemHealth #AIinHealthcare #HealthcareAI  #HealthTech #EarlyDiseaseDetection lucemhealth.com Download the transcript here

Sean Cassidy, CEO and Co-Founder of Lucem Health, is applying AI to identify patients at high risk of undiagnosed conditions like cancer and diabetes.  The goal is to facilitate earlier diagnosis and treatment by flagging patients that need screening based on the AI plaform's ability to analyze EHR data and demographics of diverse patient populations to ensure broad scalability. This technology was designed to integrate into existing clinical workflows for established screening procedures rather than making direct treatment recommendations.  Sean explains, "The origin of the company, the idea for the company, originated within Mayo Clinic in about 2020. Mayo Clinic has faced a challenge, and I think sometimes continues to face a challenge that a lot of researchers in AI have faced, which is how do you get promising AI in a clinical context from the so-called bench to the bedside? How do you get it from the lab into clinical practice? And what they realized was that while the data science and the AI part of it is really interesting, what was needed was scaffolding around the AI to facilitate integration with data and integration with workflows, a measurement and monitoring system, and so on and so forth." "We are trying to facilitate, and you're going to see us begin to expand the aperture, if you like, or open the aperture of how we position the company. Because as we've gone on, we have realized that the opportunity here is to actually help healthcare provider organizations, health systems, and so on, create really high-impact care delivery programs that have at their core or feature at their core earlier diagnosis, accelerated treatment, earlier treatment and therefore better outcomes for patients and hopefully even saved lives. So that's the generic approach that we take."  #LucemHealth #AIinHealthcare #HealthcareAI  #HealthTech #EarlyDiseaseDetection lucemhealth.com Listen to the podcast here

Aortic Regurgitation: Beyond the Valve   Guest: Vidhu Anand, M.B.B.S. Host: Kyle Klarich, M.D.   In this episode of Mayo Clinic's “Interviews With the Experts,” Dr. Klarich and Dr. Anand discuss evolving approaches to assessing left ventricular remodeling in chronic aortic regurgitation. Dr. Vidhu Anand discusses research showing that LV volumes, global longitudinal strain, and myocardial fibrosis can detect dysfunction earlier than traditional guideline thresholds. Listeners can expect to better understand the role of multimodality imaging, extra valvular involvement, and practical steps echocardiographers can take to optimize AR assessment.    Topics Discussed: What imaging markers help detect early myocardial dysfunction in AR, and how do they assist in risk stratification? Guidelines traditionally focus on LV dimensions and ejection fraction for surgical decision-making in AR. Is there any data that guidelines may not be capturing patients at the optimal time? Is there a role of multimodality imaging in AR? What practical steps can a sonographer or echocardiographer today to bring their AR assessment closer to what your research suggests is optimal?     Please reference Dr. Anand's research article(s) here: https://pubmed.ncbi.nlm.nih.gov/39545891/ https://pubmed.ncbi.nlm.nih.gov/33253815/ https://pubmed.ncbi.nlm.nih.gov/39218370/   Connect with Mayo Clinic's Cardiovascular Continuing Medical Education online at https://cveducation.mayo.edu or on Twitter @MayoClinicCV and @MayoCVservices. LinkedIn: Mayo Clinic Cardiovascular Services Cardiovascular Education App: The Mayo Clinic Cardiovascular CME App is an innovative educational platform that features cardiology-focused continuing medical education wherever and whenever you need it. Use this app to access other free content and browse upcoming courses. Download it for free in Apple or Google stores today! No CME credit offered for this episode.   Podcast episode transcript found here.

The Real Economics of Rural Surgery with Dr. Randy Lehman In this episode of the BOSS Business of Surgery Series, host Dr. Amy Vertrees sits down with rural surgeon Dr. Randy Lehman for a wide-ranging conversation about rural surgery, financial freedom, and the future of surgical practice. Dr. Lehman shares his unconventional journey, from growing up on a farm in northwest Indiana to becoming a national advocate for rural surgery—complete with a helicopter commute between hospitals. Together, they explore what makes rural surgery uniquely fulfilling, why independent practices struggle in today's healthcare economy, and how financial independence can transform a surgeon's career options and impact. What You'll Learn in This Episode Dr. Lehman's Path to Rural Surgery Growing up on a farm, switching from pre-pharmacy to pre-med, and discovering a passion for rural surgery at Purdue and UC Medical School. He describes the unexpected doors that opened and closed along the way, eventually leading him to Mayo Clinic's rural surgery track and a broad, high-volume surgical experience. What Rural Surgeons Really Do Rural surgery offers a broad scope of practice and the ability to care for patients of all ages—often with higher compensation for lower-acuity operations. Dr. Lehman shares examples from his own practice, which spans carpal tunnels to hysterectomies to skin cancer flaps, as well as why he avoids highly complex cases that require tertiary-care resources. Training That Prepares You for Everything He explains the difference between simply rotating through a rural hospital and completing true rural surgery training, which requires high volume across multiple specialties. His own training included over 1,600 cases—far above the national average. The Hard Truth About Practice Models Dr. Lehman opens up about the highs and lows of his post-residency years, including: Pursuing a job at his hometown hospital after it was sold Building a dual-location practice between two small hospitals Attempting an independent practice with $600k annual overhead and only $350k collection Writing $20–30k checks every few weeks just to keep the doors open The takeaway: in today's economic environment, hospitals subsidize surgeons because they recoup facility fees—while most independent practices cannot survive on professional fees alone. Understanding the Economics: RVUs, Overhead, and Reality He breaks down why his independent practice collected only $57 per RVU versus over $100 per RVU when employed—and what that means for surgeons who dream of autonomy. Dr. Lehman and Dr. Bertrand discuss the impact of decreasing reimbursement, increasing overhead, and the future risk of efficiency adjustments and bundled CPT payments. Financial Freedom as a Career Strategy Dr. Lehman's philosophy is simple and powerful: live on very little early in your career, invest wisely, and achieve financial independence fast. He shares: How buying an $86,000 home allowed him to reach financial freedom within two years Why minimalism amplifies your negotiating power The role of real estate in accelerating independence How financial freedom allows him to give away hundreds of thousands of dollars each year Why money magnifies your character—good or bad Building “The Rural American Surgeon” Podcast Despite costing nearly $50,000 per year to produce, his podcast is a passion project aligned with his goal of becoming a national rural surgery leader. He shares why telling these stories matters for rural hospitals, local economies, and the future surgical workforce. Entrepreneurial Thinking in Medicine Dr. Vertrees and Dr. Lehman close with a powerful discussion on why physicians must think like entrepreneurs—not simply RVU generators. They explore how surgeons can reclaim autonomy, redefine their value, and build careers with freedom, flexibility, and mission at the center. Chapters 00:00:00 – Dr. Randy Lehman's Background and Journey 00:03:47 – The Scope and Benefits of Rural Surgery 00:06:00 – Rural Surgery Training and Case Volume 00:13:18 – Practice Models After Residency: Wins and Struggles 00:20:04 – The Real Economics of Surgical Practice 00:29:56 – Financial Philosophy & Becoming Independent Early 00:42:07 – Creating The Rural American Surgeon Podcast 00:47:56 – Entrepreneurial Mindset and Physician Autonomy Action Items & Takeaways Seek a true rural surgery training track, not just rural exposure. Prioritize high-volume operative experience during residency. Buy a modest first home to accelerate financial independence. Practice generosity early, regardless of income. Explore rural surgery as a deeply rewarding and high-impact career path. Connect with Dr. Lehman at ruralamericansurgeon.com for more resources.

What happens when coaching meets improv? In this episode, Cathy Sykora speaks with Betsy Salkind and Amy Warshawsky, co-authors of Coaching with a Twist: Improv for Coaches. With backgrounds in health coaching, leadership, somatics, and comedy, Betsy and Amy have created a dynamic and experiential approach to coach training that blends improv exercises with foundational coaching skills. They explain how play and presence deepen learning, increase client connection, and make coaching more effective—and more fun. Whether you're a seasoned coach or just starting out, their fresh take on training and development is both practical and transformative. In this episode, you'll discover: How Betsy and Amy transitioned from mentor coaches to co-creators of an improv-based coaching model The similarities between improv and motivational interviewing Why experiential learning is more "sticky" than traditional training methods How play and improvisation enhance presence, creativity, and emotional regulation Why they created a safe, supportive environment for learning through coaching with a twist A powerful improv exercise called "three-word coaching" you can try today The benefits of supervision and their monthly BNA Coaching Salon Memorable Quotes: "Ultimately, if we are coaching well, we're improvising." "No rules, only happy accidents." "When you're playing and having fun, you are not in fear." Bios:  Betsy Salkind, PCC, NBC-HWC, is a health and mentor coach with expertise in team, group, and leadership coaching. A professional standup comic and TV writer, she trained at the Mayo Clinic and holds an MS in Organization Studies from MIT Sloan. Amy J. Warshawsky, MCC, NBC-HWC, is a leadership and mentor coach known for integrating somatic practices into coaching. She has held roles in nonprofit and higher education, and holds degrees from Northwestern University and Cornell. Together, they co-founded BNA Mentor Coaching and co-authored Coaching with a Twist: Improv for Coaches. Mentioned in This Episode: BNA Mentor Coaching Coaching with a Twist: Improv for Coaches Links to Resources: Health Coach Group Website: thehealthcoachgroup.com (https://www.thehealthcoachgroup.com) Special Offer: Use code HCC50 to save $50 on the Health Coach Group website Leave a Review: If you enjoyed the podcast, please consider leaving a five-star rating or review on Apple Podcasts.

Farfesa Abba Zubair Chedi na asibitin Mayo Clinic da ke Amurka, dan asalin jihar Kano ne a Najeriya da ya yi kaurin suna a Amurka, musamman a lokacin da ya shiga binciken yadda za a yi amfani da kimiyyar kwayar halitta ta 'stem cell' wajen kirkirar sassan jikin bil'adama, kamar zuciya da huhu don dasa wa mutanen da sassan jikin ya lalace ba tare da jiran sai wani ya mutum a cire a saka wa wani ba.

This interview took place on a historic day: the FDA removed the black box warning for HRT (hormone replacement therapy) after 20 years. My guest, Dr. Mariza Snyder, author of The Perimenopause Revolution, explains why this matters and why women have been suffering needlessly for decades while doctors dismissed their symptoms as "just aging" or "just stress." Perimenopause is the 4 to 10-year transition where hormones wildly fluctuate before menopause, and Dr. Snyder calls it "the window of vulnerability." She uses a powerful metaphor: imagine estrogen as your brain's master CEO who shows up like clockwork from 9 AM to 6 PM for 30 years. Then, suddenly, without warning, it shows up at 2 PM one day and leaves at 11 PM, then shows up at 6 AM the next day and leaves at 11 AM. Your brain scrambles trying to regulate energy, neurotransmitters, sleep, mood, and cravings. The most compelling insight of our conversation is a Mayo Clinic study that found 84% of menopausal women don't seek care. Why? Because they feel judged in the doctor's office.  Dr. Snyder wrote her book as the roadmap she desperately needed when she started her own perimenopause journey, connecting symptoms to future health outcomes and providing practical solutions beyond just "you're getting older."  

This is Part 2 of our conversation with Dr. Zwade Marshall and the final episode for a while as Dr. Disha begins a new chapter, opening her own Direct Primary Care practice. Dr. Zwade Marshall is an Emory and Harvard trained anesthesiologist, interventional pain specialist, CMO of Regenerative Spine and Pain Specialists, and co-founder and CEO of Doc2Doc Lending, a lending platform created by doctors for doctors. In this closing installment, Dr. Marshall explains what it truly means for physicians to make empowered decisions when opening, financing, and building their own practice. He shares the financial pitfalls many doctors overlook, the importance of understanding market demographics, and how tools such as Tenant Improvement Allowance and ownership-based tax benefits can significantly shape long-term wealth for private practice physicians. If you are planning to open a clinic, transition into DPC, or simply want to understand practice financing more clearly, this episode offers practical guidance that medical training rarely covers. Key Topics Covered: 1. How empowered doctors make empowered decisions Why physicians must learn to evaluate risk, financing, long-term ROI, and operational decisions with the same confidence they use in clinical care—and how that mindset shift changes everything. 2. Financing your own medical practice Understanding budget allocations, startup capital, cost projections, and what you should (and shouldn't) take on debt for when building your practice from scratch. 3. The Market Demographic Survey What a demographic report actually tells you, how it affects patient volume and payer mix, and why it's one of the most critical early steps in choosing your practice location. 4. Tenant Improvement Allowance (TIA) What TIA is, how landlords use it to attract medical tenants, how much you can negotiate, and how it reduces upfront buildout costs for new practice owners. 5. Why owning your medical practice building is a long-term wealth strategy The tax benefits, equity growth, and stability that come with being your own landlord—and why many physicians only realize these advantages too late in their careers. 6. Financing (How do doctors get capital?) Especially when they don't have revenue yet. Listener Takeaways: The mindset shifts required to become an empowered, financially confident physician How to allocate budget and financing when opening a practice Why demographic surveys are essential for choosing the right location How Tenant Improvement Allowances work and how to negotiate them The long-term tax benefits and wealth advantages of owning your practice property How platforms like Doc2Doc support physicians with smarter, physician-centered lending Real-world financial advice every doctor should know before launching a private practice or DPC model Connect with Us: Host: Dr. Disha Spath, The Frugal Physician Guest: Dr. Zwade Marshall, CEO of Doc2Doc Lending   This episode is brought to you by Doc2Doc Lending. Doc2Doc Lending offers personal loans up to $100,000 for doctors — designed to help you consolidate debt, invest in your goals, or get ahead financially. Founded by doctors for doctors, we make funding simple, transparent, and tailored to the medical community. Visit their website at: https://www.doc2doclending.com/personal-loans-for-physicians/?utm_source=FrugalPhysician&utm_medium=podcast&utm_campaign=FP   This episode is brought to you by Black Swan Real Estate, led by physician-investor Dr. Elaine Stageberg.  Dr. Stageberg, a Mayo Clinic–trained physician, together with her husband Nick, has spent years building Black Swan Real Estate into a diversified, large-scale portfolio now approaching half a billion dollars across 2,000 doors.  Now, through their Secure Freedom Fund, a 10% fixed rate of return offering, you can invest alongside them. The Secure Freedom Fund offers institutional-quality real estate opportunities—designed to deliver strong cash flow, long-term growth, and remarkable tax advantages.  This fund is uniquely structured so that each investor can tailor it to their own individual goals: a minimum investment of just $25,000, the ability to choose monthly cashflow distributions or to elect the compounding option for higher overall growth, the option to exit the fund on your timing, the flexibility to invest in your personal name, a trust, an LLC, or a retirement account, and so much more.  If you're an accredited investor who's ready to diversify beyond Wall Street and invest with experienced, trust worthy operators who've been exactly where you are, visit SecureFreedomFund.com today to learn more. From there, you can review the slides, watch the webinar, and even a book a call directly 1:1 with Dr. Elaine Stageberg.  That's SecureFreedomFund.com.

Published Dec. 4, 2025In this episode of “Answers From the Lab,” host Bobbi Pritt, M.D., chair of the Division of Clinical Microbiology at Mayo Clinic, is joined by William Morice II, M.D., Ph.D., president and CEO of Mayo Clinic Laboratories, to discuss Protecting Access to Medicare Act (PAMA) reform and the first reported death from alpha-gal syndrome. Later, Dr. Pritt welcomes Chris Garcia, M.D., Mayo Clinic Laboratories' chief digital innovation officer and medical director of BioPharma Diagnostics, to explore how biopharma diagnostics advance research and development. PAMA reform update (00:33): Get the latest on where reform to PAMA stands following the federal government's reopening.Alpha-gal syndrome case (03:22): Learn about the first known death from alpha-gal syndrome and diagnostic testing for this tick-bite-triggered red meat allergy.Biopharma's role in research and development (07:52): Discover how biopharma diagnostics fuel innovation and how digital tools are expanding its future impact.  Note: Information in this post was accurate at the time of its posting.ResourcesBioPharma Diagnostics: Connecting pharma and biotechTick-borne disease: An expanding geographic threat

When a crisis hits, you don't get a practice round, you get a choice. In this episode, Dr. Richard Winters, Mayo Clinic emergency physician and Director of Leadership Development, breaks down how exceptional leaders move between rapid-fire crisis decisions and group problem-solving. He shares frameworks that help you decide when to call an expert, when to lead from the front, and when to slow down and get the room aligned. We also talk about how to run better meetings, end toxic back channels, spot and prevent burnout, and create engagement that keeps people showing up.  In This Episode, You Will Learn How to MAP DECISIONS using the Cynefin Framework. When to CALL an expert and when to BRING A GROUP TOGETHER to build a shared reality. How to run BETTER MEETINGS with breakouts and report-outs. Why the powerful LEADER does less. Ways to IDENTIFY & COUNTER BURNOUT before cynicism spreads. How to TURN BACK CHANNELS into FORWARD CONVERSATIONS. A COACHING APPROACH to help people problem-solve. STEPS to AMPLIFY ENGAGEMENT so people feel seen, aligned, and purposeful. Check Out Our Sponsors: Shopify - Sign up for a one-dollar-per-month trial period at shopify.com/monahan Quince - Step into the holiday season with layers made to feel good and last from Quince. Go to quince.com/confidence Timeline - Get 10% off your first Mitopure order at timeline.com/CONFIDENCE. Northwest Registered Agent - protect your privacy, build your brand and get your complete business identity in just 10 clicks and 10 minutes! Visit https://www.northwestregisteredagent.com/confidencefree Resources + Links Learn more about Dr. Richard Winters HERE Call my digital clone at 201-897-2553!  Visit heathermonahan.com Sign up for my mailing list: heathermonahan.com/mailing-list/  Overcome Your Villains is Available NOW! Order here: https://overcomeyourvillains.com  If you haven't yet, get my first book Confidence Creator Follow Heather on Instagram & LinkedIn Dr. Richard on LinkedIn

This podcast is brought to you by Outcomes Rocket, your exclusive healthcare marketing agency. Learn how to accelerate your growth by going to⁠ outcomesrocket.com When people gain access to their own brain data and personalized guidance, they can significantly improve their sleep, focus, stress levels, and long-term cognitive health. In this episode, Ariel Garten, neuroscientist, psychotherapist, and co-founder of MUSE, explains how real-time brain tracking is transforming both personal wellness and clinical care. She describes how MUSE's soft, low-profile headband uses EEG and fNIRS to measure brain activity and blood oxygenation, enabling accurate sleep tracking, attention training, and cognitive insight. Ariel highlights the company's strong research foundation, including 200+ published studies and multiple Mayo Clinic trials showing reduced stress, improved fatigue, and a 54% decrease in burnout among clinicians using MUSE for just five minutes a day. She also details new features like the Digital Sleeping Pill, deep sleep stimulation, and an AI sleep coach, and shares how researchers, clinicians, and pharma teams are using MUSE to power distributed studies and measure neurophysiological responses to interventions. Tune in and learn how personalized brain insights could transform sleep, cognition, and the future of preventive health! Resources Connect with and follow Ariel Garten on LinkedIn. Follow MUSE on LinkedIn and visit their website! Email the MUSE team directly here.

This week on Health Matters, Courtney sits down with Dr. Braden Kuo, Chief of the Division of Digestive & Liver Diseases at NewYork-Presbyterian and Columbia. Dr. Kuo covers common gut problems during the holiday season, a time of indulgent meals and treats. From bloat to heartburn to travel-related stomach issues, Dr. Kuo is a trove of information and practical tips for navigating holiday festivities with good choices for your gut.  ___ Dr. Braden Kuo is a leading neurogastroenterologist specializing in gastrointestinal motility and the relationship between the brain, nervous system and digestive system. He is the Chief of the Division of Digestive and Liver Diseases at NewYork-Presbyterian/ColumbiaUniversity Irving Medical Center and Columbia University Vagelos College of Physicians andSurgeons. Dr. Kuo received his medical degree from Jefferson Medical College and completed his residency at the University of Texas Southwestern Medical Center before arriving at Massachusetts General Hospital, where he served as director of the Center for Neurointestinal Health. He also completed formal training in clinical research, earning a Master of Science from the Harvard T.H. Chan School of Public Health, and subspecialty training in neurogastroenterology and motility at Mayo Clinic.___Health Matters is your weekly dose of health and wellness information, from the leading experts. Join host Courtney Allison to get news you can use in your own life. New episodes drop each Wednesday.If you are looking for practical health tips and trustworthy information from world-class doctors and medical experts you will enjoy listening to Health Matters. Health Matters was created to share stories of science, care, and wellness that are happening every day at NewYork-Presbyterian, one of the nation's most comprehensive, integrated academic healthcare systems. In keeping with NewYork-Presbyterian's long legacy of medical breakthroughs and innovation, Health Matters features the latest news, insights, and health tips from our trusted experts; inspiring first-hand accounts from patients and caregivers; and updates on the latest research and innovations in patient care, all in collaboration with our renowned medical schools, Columbia and Weill Cornell Medicine.To learn more visit: https://healthmatters.nyp.org

Host: Darryl S. Chutka, M.D. Guest: Cory Ingram, M.D. There are a couple outcomes in taking a medical history. Obviously, one is information gathering. You need to hear the patient's symptoms to help form your differential diagnosis. The second, and equally important, is to help establish a relationship with that patient. There are several reasons a good provider-patient relationship is important. The patient is more likely to feel positive about their medical encounter, they're more likely to be adherent to your recommendations regarding their health conditions, and they tend to be more forgiving if they experience an adverse event. What makes up a good provider-patient relationship? What can we do as clinicians to help establish a good relationship with our patients? Can we still establish a good relationship when we practice telemedicine? These are questions I'll be asking my guest, Cory Ingram, M.D., a palliative care physician at the Mayo Clinic as we discuss “Provider-Patient Relationship Skills”. Connect with us and learn more here: https://ce.mayo.edu/online-education/content/mayo-clinic-podcasts