Podcasts about piis0140

Teenage and adolescent health offers us a glimpse into the future health of the world. The Lancet Commission wrote a report in 2016 and have recently written a follow up which paints a slightly concerning picture.In this episode I look at health in this group of people, the challenges they face and what, if anything, can be done about it.Links:The Lancet Commission report summary: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)00863-3/fulltextBarriers to healthcare for adolescents: https://pmc.ncbi.nlm.nih.gov/articles/PMC8070789/Global numbers: https://www.who.int/news-room/fact-sheets/detail/adolescents-health-risks-and-solutionsOmega-3 and brain health: https://pubmed.ncbi.nlm.nih.gov/35960396/Climate Stress: https://pmc.ncbi.nlm.nih.gov/articles/PMC10154789/Free tips from Annette Du Bois (teenage coach): https://www.champs-academy.co.uk/free-help-and-support/ Hosted on Acast. See acast.com/privacy for more information.

In this episode of, Dr. Sergio Zanotti explores the vital role of enteral nutrition in the ICU—a foundational element in the prevention and treatment of disease-related malnutrition among critically ill patients. He is joined by Dr. Leah Gramlich, a distinguished gastroenterologist and physician nutrition specialist from the Royal Alexandra Hospital in Alberta, Canada. Dr. Gramlich is a Professor of Medicine at the University of Alberta and the founding president of the Canadian Nutrition Society. She has also served on the Board of Directors for the American Society for Parenteral and Enteral Nutrition and chaired the Canadian Malnutrition Task Force, bringing deep expertise to this essential topic. Additional resources: Enteral Nutrition in Hospitalized Adults. Lead Gramlich, Peggi Guenter. New Engl J Med 2025: https://pubmed.ncbi.nlm.nih.gov/40239069/ Individualized nutritional support in medical inpatients at nutritional risk: a randomized clinical trial. The EFFORT Clinical Trial. Lancet 2019: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(18)32776-4/abstract Low versus standard calorie and protein feeding in ventilated adults with shock: a randomised, controlled, multicentre, open-label, parallel-group trial (NUTRIREA-3). Lancet Respir Med 2023: https://pubmed.ncbi.nlm.nih.gov/36958363/ The effect of higher protein dosing in critically ill patients with high nutritional risk (EFFORT Protein): an international, multicentre, pragmatic, registry-based randomised trial. Lancet 2023: https://pubmed.ncbi.nlm.nih.gov/36708732/ Books mentioned in this episode: The Overstory: A Novel. By Richard Powers: https://bit.ly/43Drra1

Katherine Gourd, Acting Deputy Editor at The Lancet Oncology, and Vania Wisdom, Senior Executive Editor at The Lancet and the journal's Oncology Ambassador, join Leon Terner to share some of their experiences, impressions and highlights from this year's American Society of Clinical Oncology (ASCO) conference. If you haven't already, be sure to listen to Vania's pre-ASCO predictions podcast here: https://www.buzzsprout.com/882697/episodes/17233167Articles discussed in this podcast episode include:Zanidatamab plus chemotherapy as first-line treatment for patients with HER2-positive advanced gastro-oesophageal adenocarcinoma: primary results of a multicentre, single-arm, phase 2 study:https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(25)00287-6/fulltext?dgcid=buzzsprout_icw_podcast_asco2025_lanonc_tloClaudin-18 isoform 2-specific CAR T-cell therapy (satri-cel) versus treatment of physician's choice for previously treated advanced gastric or gastro-oesophageal junction cancer (CT041-ST-01): a randomised, open-label, phase 2 trial:https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)00860-8/fulltext?dgcid=buzzsprout_icw_podcast_asco2025_lanonc_tloRelacorilant and nab-paclitaxel in patients with platinum-resistant ovarian cancer (ROSELLA): an open-label, randomised, controlled, phase 3 trial:https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)01040-2/fulltext?dgcid=buzzsprout_icw_podcast_asco2025_lanonc_tlo#asco2025Tell us what you thought about this episodeContinue this conversation on social!Follow us today at...https://thelancet.bsky.social/https://instagram.com/thelancetgrouphttps://facebook.com/thelancetmedicaljournalhttps://linkedIn.com/company/the-lancethttps://youtube.com/thelancettv

Vania Wisdom, Senior Executive Editor at The Lancet and the journal's Oncology Ambassador, and Katherine Gourd, Acting Deputy Editor at The Lancet Oncology, join Leon Terner to share some of their experiences, impressions and highlights from this year's American Society of Clinical Oncology (ASCO) conference. If you haven't already, be sure to listen to Vania's pre-ASCO predictions podcast here: https://www.buzzsprout.com/882697/episodes/17233167Articles discussed in this podcast episode include:Zanidatamab plus chemotherapy as first-line treatment for patients with HER2-positive advanced gastro-oesophageal adenocarcinoma: primary results of a multicentre, single-arm, phase 2 study:https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(25)00287-6/fulltext?dgcid=buzzsprout_icw_podcast_asco2025_lancet_tlwClaudin-18 isoform 2-specific CAR T-cell therapy (satri-cel) versus treatment of physician's choice for previously treated advanced gastric or gastro-oesophageal junction cancer (CT041-ST-01): a randomised, open-label, phase 2 trial:https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)00860-8/fulltext?dgcid=buzzsprout_icw_podcast_asco2025_lancet_tlwRelacorilant and nab-paclitaxel in patients with platinum-resistant ovarian cancer (ROSELLA): an open-label, randomised, controlled, phase 3 trial:https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)01040-2/fulltext?dgcid=buzzsprout_icw_podcast_asco2025_lancet_tlw#asco2025Continue this conversation on social!Follow us today at...https://thelancet.bsky.social/https://instagram.com/thelancetgrouphttps://facebook.com/thelancetmedicaljournalhttps://linkedIn.com/company/the-lancethttps://youtube.com/thelancettv

Richard, Jessamy, and Gavin reflect on developments at the 78th World Health Assembly, including the passage of the pandemic agreement and shifting dynamics in global health leadership. What's next for WHO without US engagement? How has WHA changed over the years?We also address the importance of recommitting to adolescent health following our new Commission, and discuss a controversial recent study about the pace of scientific innovation.You can read the second Lancet Commission on Adolescent Health & Wellbeing here:https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)00503-3/fulltext?dgcid=buzzsprout_icw_podcast_lancetadolescenthealth25_lancetThis is the paper on the pace of scientific innovation discussed on the podcast:https://www.nature.com/articles/d41586-025-01548-4Send us your feedback!Read all of our content at https://www.thelancet.com/?dgcid=buzzsprout_tlv_podcast_generic_lancetCheck out all the podcasts from The Lancet Group:https://www.thelancet.com/multimedia/podcasts?dgcid=buzzsprout_tlv_podcast_generic_lancetContinue this conversation on social!Follow us today at...https://thelancet.bsky.social/https://instagram.com/thelancetgrouphttps://facebook.com/thelancetmedicaljournalhttps://linkedIn.com/company/the-lancethttps://youtube.com/thelancettv

Changsong Qi joins Chloe Wilson and Ben Abbott of The Lancet to discuss their recently published phase 2 randomised controlled trial investigating Claudin-18 isoform 2-specific CAR T-cell therapy for previously treated advanced gastric or gastro-oesophageal junction cancer.Read the full article:https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)00860-8/fulltext?dgcid=buzzsprout_icw_podcast_May_25_lancetContinue this conversation on social!Follow us today at...https://thelancet.bsky.social/https://instagram.com/thelancetgrouphttps://facebook.com/thelancetmedicaljournalhttps://linkedIn.com/company/the-lancethttps://youtube.com/thelancettv

*20%discount code below* One of my goals with this podcast is not to only have some of the best speakers on topics that interest me on, but also to have a neuroscientist on. Which happened in this conversation! I was excited to have Amanda Higgins Neuroscience PhD on to discuss brain aging and why its not only hormones and our weight we should be paying attention to in perimenopause and mid life. We seem to forget about the brains importance when it comes to health and feeling good. And this is definitely an OVERLOOKED TOPIC when it comes to perimenopause. So what really happens to the brain as we age and what can we do about it? In this episode, I sit down with a neuroscientist to explore the science of cognitive decline, the root causes of dementia, and the practical strategies we can use to protect and enhance brain function over time. We discuss the latest research on brain aging, key lifestyle habits that support long-term cognitive health, and actionable steps you can take to keep your mind sharp, resilient, and high-performing at every stage of life. Whether you're looking to prevent dementia, optimize mental clarity, or simply better understand your brain, this conversation offers powerful insights grounded in science. If you are interested in finding out more about cGP and Amandas work, you can do so here; cGPMAX Instagram: https://www.instagram.com/cgp.max/ cGPMAX Facebook: https://www.facebook.com/cgp.lab cGPMAX website for supplements: www.cgpmax.com Science behind cGP: www.cgp-health.com LinkedIn - https://www.linkedin.com/in/amandawiggins/ Discount code for your listeners: ModelHealth20 Enter discount code at checkout for 20% off all products. One time use per customer. Lancet Study on Dementia Prevention - https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)01296-0/abstract

Welcome back to part 2 of our 'Science of Prayer' series! Back in April we discussed prayer with Aiden the VVitch, with a focus on the use of prayer in a variety of spiritual and occult settings. In this episode, the hosts tackle the science behind prayer, investigating the mechanisms behind how prayer affects our brains as well as the controversial fields of faith healing and whether prayer can benefit our health. BIBLIOGRAPHY Lancet Review of religion, spirituality, and medicine which touches (heh) on faith healing: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(98)07376-0/fulltext Intercessory prayer for...COVID?! https://www.cell.com/heliyon/fulltext/S2405-8440(23)09619-6 Some small benefits to health observed from a prayer practice: https://doi.org/10.1037/0003-066X.58.1.36 What happens to our brain during prayer? A review: DOI: 10.1097/HRP.0000000000000232 Neural mechanisms of pain modulation during prayer - the 'Mr Hansen' study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487465/ fMRI during Quran recitations: https://doi.org/10.1007/s11042-023-15588-3 How valid is neuroimaging during prayer, anyway? https://doi.org/10.1037/a0039124 The wild 'sutra is stored in the frontal lobe' story https://www.tandfonline.com/doi/full/10.1080/13554790903559689

Gavin, Richard, and Jessamy return to the studio to discuss some publications that caught their eye this month, and in doing so set themselves the lofty goal of examining how meaning, purpose, optimism, and social context shape our understanding of health beyond traditional clinical measures. We also ponder the future of research and higher education in the face of funding challenges in both the US and the UK.Articles mentioned in this episode:The Global Flourishing Study: https://www.nature.com/articles/s44220-025-00423-5The second Lancet Commission on adolescent health and wellbeing: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)00503-3/fulltext?dgcid=buzzsprout_tlv_podcast_May_25_lancetStanding up for gender justice: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)00679-8/fulltext?dgcid=buzzsprout_tlv_podcast_May_25_lancetHow the United States became a science superpower: https://www.nature.com/articles/d41586-025-01146-4Universities grip financial crisis – but at what cost to the nation?: https://www.universitiesuk.ac.uk/what-we-do/creating-voice-our-members/media-releases/universities-grip-financial-crisis-whatSend us your feedback!Read all of our content at https://www.thelancet.com/?dgcid=buzzsprout_tlv_podcast_generic_lancetCheck out all the podcasts from The Lancet Group:https://www.thelancet.com/multimedia/podcasts?dgcid=buzzsprout_tlv_podcast_generic_lancetContinue this conversation on social!Follow us today at...https://thelancet.bsky.social/https://instagram.com/thelancetgrouphttps://facebook.com/thelancetmedicaljournalhttps://linkedIn.com/company/the-lancethttps://youtube.com/thelancettv

By 2030, over 1.2 billion women will be in menopause, yet most were never taught what to expect. In this episode, Dr. Josh Axe shares how to manage symptoms naturally, feel empowered, and reclaim your health through this life-changing transition. In this episode, you'll discover: The top 10 symptoms and what's really causing them Simple diet and lifestyle shifts to reduce hot flashes, mood swings, and weight gain The best herbs and supplements for symptom relief Top triggers that make symptoms worse and how to avoid them Pros and cons of hormone replacement therapy You'll leave this episode with practical tools, deeper insight, and natural strategies to take control of your hormones, energy, and health—starting today. We've created a full blog post that walks through the main points and insights from this episode. If you'd like to dive deeper or revisit the information later, this is a helpful resource to keep on hand. Read it here → https://thehealthinstitute.com/2025/05/16/the-natural-womans-guide-to-menopause-from-hot-flashes-to-hormone-harmony/  ------  Staying healthy in today's world is an upstream battle. Subscribe to Wellness Weekly, your 5-minute dose of sound health advice to help you grow physically, mentally, and spiritually. Every Wednesday, you'll get:  Holistic health news & life-hacks from a biblical world view Powerful free resources including classes, Q&As, and guides from Dr. Axe The latest episodes of The Dr. Josh Axe Show ------  Links:  https://pmc.ncbi.nlm.nih.gov/articles/PMC10780928/ https://healthmatters.nyp.org/how-to-prevent-menopause-weight-gain/ https://pmc.ncbi.nlm.nih.gov/articles/PMC9258798/ https://bmcpublichealth.biomedcentral.com/articles/10.1186/s12889-024-19280-5 https://www.evernow.com/menopause-study?srsltid=AfmBOooQmZQD8p3CTJzICs9zTTlSZ2d_GrKcOg1JTryTFEyJo9VMGsCI https://www.hopkinsmedicine.org/health/conditions-and-diseases/introduction-to-menopause https://swhr.org/health_focus_area/menopause/ https://www.ncbi.nlm.nih.gov/books/NBK285446/ https://www.statista.com/statistics/1450588/menopause-symptoms-us-women/ https://www.uscjournal.com/articles/menopause-cholesterol-and-cardiovascular-disease-0?language_content_entity=en https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2110996 https://www.mayoclinic.org/diseases-conditions/menopause/symptoms-causes/syc-20353397 https://my.clevelandclinic.org/health/diseases/21608-perimenopause https://journals.lww.com/menopausejournal/abstract/2007/14040/chilliness__a_vasomotor_symptom_in_japan.22.aspx https://www.theguardian.com/society/article/2024/jul/21/women-dealing-with-menopause-preparation-planning-australia https://acupuncturehealthcalgary.com/the-second-spring-menopause-in-chinese-medicine/ https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)02799-X/fulltext? https://pubmed.ncbi.nlm.nih.gov/35983178/ https://link.springer.com/article/10.1007/s11920-023-01447-3 https://pmc.ncbi.nlm.nih.gov/articles/PMC10074318/ https://my.clevelandclinic.org/health/diseases/21608-perimenopause https://www.mdpi.com/1420-3049/26/24/7421 https://pubmed.ncbi.nlm.nih.gov/38934532/ https://pubmed.ncbi.nlm.nih.gov/38725785/ https://pubmed.ncbi.nlm.nih.gov/25423327/ https://pubmed.ncbi.nlm.nih.gov/37378077/ https://pubmed.ncbi.nlm.nih.gov/36641259/ https://pubmed.ncbi.nlm.nih.gov/36746877/ ​​https://www.uclahealth.org/sites/default/files/documents/cf/menopause-understanding-mediterranean-diet.pdf https://womensmentalhealth.org/posts/mediterranean-diet-benefits-perimenopausal-women-with-hot-flashes/ ------  Ads:  Get 15% off your first order with the code AXE at oneskin.co/AXE. Even if your bloodwork looks "normal," your symptoms could point to Cell Danger Response (CDR). Discover how to break free from CDR and unlock your full potential at https://beyondbloodwork.com/.

The Big Baby Trial study has been published,and are already being used to justify inductions at 38 weeks... but what did the study ACTUALLY show? I chat to doula Samantha Gadsden about this study, and why despite it being touted as evidence for early inductions, the results actually show the opposite!You can find the study here: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)00162-X/fulltextSamantha (Sam) Gadsden is one of the UK's leading doulas, specialising in home birth, freebirth, and virtual support. With over a decade of experience, she is renowned for empowering families through pregnancy, birth, and beyond, championing the sacred nature of birth and the right to self-advocacy. As an outspoken activist, she has led campaigns against obstetric violence and supported countless families facing domestic abuse, social services involvement, and trauma.Samantha runs a thriving online community for parents, mentors birth professionals, and regularly contributes to media discussions on birth and parenting. She is the former co-host of The Birth Activist podcast and is soon launching her new podcast The Village Wise Woman. Deeply rooted in her belief in community and spirituality, Samantha uses her work to ensure that those who cannot afford her services are still able to access the care they deserve. Sam's home birthsupport group can be found here: https://www.facebook.com/groups/homebirthsupportuk/ and she can be found on instagram at https://www.instagram.com/samanthagadsdendoulaErin Fung is a birth educator and activist, providing classes and support to anyone wanting an informed and positive birth. Her courses can be found www.better-birth.co.uk or on all social media channels @betterbirthukDisclaimer: The information and provided on this podcast does not, and is not intended to, constitute medical or legal advice; instead, all information available on this site are for general informational purposes only. We reserve the right to supplement, change or delete any information at any time. The information and materials on the podcast is provided "as is"; no representations are made that the content is error-free. Whilst we have tried to ensure the accuracy and completeness of the information we do not warrant or guarantee the accurateness. All liability with respect to actions taken or not taken based on the content of the podcast are hereby expressly disclaimed. Your use of content contained in or linked to this podcast is entirely at your own risk. The Better Birth podcast accepts no liability for any loss or damage howsoever arising out of the use or reliance on the content.

On todays episode we will be discussing Transcranial Magnetic Stimulation with a very special guest, Dr. Jonathan Downar. We will also discuss the ONE-D and THREE-D trails.Three-D Trial: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(18)30295-2/abstract'One-D Trial: https://www.researchsquare.com/article/rs-5679327/v1SAINT TMS: https://psychiatryonline.org/doi/10.1176/appi.ajp.2019.19070720

Send us a textIn this show, the boys discuss the alarming case of the birth rate in many Western countries declining. Whilst globally it is still rising, the longer trend is downward. Is this a case for our eventual extinction?But what do you think?Links used during the show-https://www.cbsnews.com/news/costco-butter-recall/-https://www.un.org/development/desa/pd/sites/www.un.org.development.desa.pd/files/wpp2022_summary_of_results.pdf-https://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2824%2900550-6/fulltext?dgcid=twitter_organic_gbd24_lancet&hss_channel=tw-27013292-https://en.wikipedia.org/wiki/Returning_soldier_effect-http://content.time.com/time/magazine/article/0,9171,773794,00.htmlWhat are your thoughts on this subject? Do you agree or disagree? And are there other things you feel they should have covered?Tune in and listen to the discussion, and please let us have your feedback.Although we much prefer effusive praise

There are now multiple phase 3 studies on combination transarterial chemoembolization (TACE) and immunotherapy showing a significant benefit over TACE alone. How do these findings change the hepatocellular carcinoma (HCC) treatment algorithm? In this multidisciplinary episode of the BackTable Podcast, Dr. Richard Finn (Medical Oncologist at UCLA) and Dr. Julius Chapiro (Interventional Radiologist at Yale University) join host Dr. Chris Beck to discuss immunotherapy, TACE, emerging trends in HCC treatment, and the future of the field.---This podcast is supported by an educational grant from Guerbet.---SYNPOSISThe doctors highlight the importance of high quality clinical data and the pivotal studies shaping current best practices. They explore the role of the different players on the multidisciplinary team and compare the oncologic and radiologic perspectives. Additionally, they discuss the synergy between TACE and immunotherapy, the criteria for selecting appropriate treatments, and the ongoing need for research and collaboration.---TIMESTAMPS00:00 - Introduction 03:35 - HCC from an Oncologic Perspective 05:33 - Radiological Perspective on Liver Cancer06:50 - Referral Patterns and Organizing a Multidisciplinary Approach18:01 - Explaining TACE and Variations in the Procedure27:27 - Choosing the Right Procedure for HCC36:13 - Making a Decision on Medical Treatment Candidacy 42:23 - Importance of Data Driven HCC Treatment, Practical Insights, and Studies to Know55:30 - Planning an Approach for a TACE Procedure01:02:26 - Final Thoughts and Future Prospects in Liver Cancer Treatment---RESOURCESBarcelona Staging System:https://www.ncbi.nlm.nih.gov/books/NBK569796/table/Ch3-t0001/TRACE Trial:https://pubs.rsna.org/doi/full/10.1148/radiol.211806PREMIERE Trial:https://www.gastrojournal.org/article/S0016-5085(16)34971-X/fulltextEMERALD-1 Trial:https://ascopubs.org/doi/10.1200/JCO.2024.42.3_suppl.LBA432LEAP O12 Study:https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)02575-3/abstract

Here Dr Tara Walker talks about the latest research on how exercise impacts the brain and what the best exercise forms are to protect your cognitive ability as you age.

Listen as we discuss the highly-awaited ESOPEC trial, which examines treatment regimens for esophageal and EGJ adenocarcinoma. Wildly impress your thoracic attendings or peers with your nuanced knowledge! FLOT who? You'll know. Pull out the paper and listen along! Learning Objectives: -Discuss the patient population in the ESOPEC trial -Discuss the main differences between the ESOPEC trial and the CROSS trial -Describe the main drawbacks between FLOT and the CROSS regimen. Hosts: Chloe Hanson MD, Brian Louie MD, and Peter White MD   Referenced Material https://www.nejm.org/doi/full/10.1056/NEJMoa2409408 Hoeppner J, Brunner T, Schmoor C, Bronsert P, Kulemann B, Claus R, Utzolino S, Izbicki JR, Gockel I, Gerdes B, Ghadimi M, Reichert B, Lock JF, Bruns C, Reitsamer E, Schmeding M, Benedix F, Keck T, Folprecht G, Thuss-Patience P, Neumann UP, Pascher A, Imhof D, Daum S, Strieder T, Krautz C, Zimmermann S, Werner J, Mahlberg R, Illerhaus G, Grimminger P, Lordick F. Perioperative Chemotherapy or Preoperative Chemoradiotherapy in Esophageal Cancer. N Engl J Med. 2025 Jan 23;392(4):323-335. doi: 10.1056/NEJMoa2409408. PMID: 39842010. https://www.nejm.org/doi/full/10.1056/NEJMoa1112088 van Hagen P, Hulshof MC, van Lanschot JJ, Steyerberg EW, van Berge Henegouwen MI, Wijnhoven BP, Richel DJ, Nieuwenhuijzen GA, Hospers GA, Bonenkamp JJ, Cuesta MA, Blaisse RJ, Busch OR, ten Kate FJ, Creemers GJ, Punt CJ, Plukker JT, Verheul HM, Spillenaar Bilgen EJ, van Dekken H, van der Sangen MJ, Rozema T, Biermann K, Beukema JC, Piet AH, van Rij CM, Reinders JG, Tilanus HW, van der Gaast A; CROSS Group. Preoperative chemoradiotherapy for esophageal or junctional cancer. N Engl J Med. 2012 May 31;366(22):2074-84. doi: 10.1056/NEJMoa1112088. PMID: 22646630. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(18)32557-1/abstract Al-Batran SE, Homann N, Pauligk C, Goetze TO, Meiler J, Kasper S, Kopp HG, Mayer F, Haag GM, Luley K, Lindig U, Schmiegel W, Pohl M, Stoehlmacher J, Folprecht G, Probst S, Prasnikar N, Fischbach W, Mahlberg R, Trojan J, Koenigsmann M, Martens UM, Thuss-Patience P, Egger M, Block A, Heinemann V, Illerhaus G, Moehler M, Schenk M, Kullmann F, Behringer DM, Heike M, Pink D, Teschendorf C, Löhr C, Bernhard H, Schuch G, Rethwisch V, von Weikersthal LF, Hartmann JT, Kneba M, Daum S, Schulmann K, Weniger J, Belle S, Gaiser T, Oduncu FS, Güntner M, Hozaeel W, Reichart A, Jäger E, Kraus T, Mönig S, Bechstein WO, Schuler M, Schmalenberg H, Hofheinz RD; FLOT4-AIO Investigators. Perioperative chemotherapy with fluorouracil plus leucovorin, oxaliplatin, and docetaxel versus fluorouracil or capecitabine plus cisplatin and epirubicin for locally advanced, resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4): a randomised, phase 2/3 trial. Lancet. 2019 May 11;393(10184):1948-1957. doi: 10.1016/S0140-6736(18)32557-1. Epub 2019 Apr 11. PMID: 30982686. ***Fellowship Application Link: https://forms.gle/PQgAvGjHrYUqAqTJ9 Please visit https://behindtheknife.org to access other high-yield surgical education podcasts, videos and more. If you liked this episode, check out our recent episodes here: https://app.behindtheknife.org/listen

Gavin, Richard, and Jessamy reunite for another bonus episode, covering the first three months or so of health in the US under Trump. What do the appointments tell us about the administration's agenda? How can institutions stand up to cuts and intimidation? We also look at gender justice in global health as laid out by the excellent new Commission in The Lancet, and highlight that the world's impressive gains on maternal and newborn mortality are slowing - what more needs to be done?You can read "Achieving gender justice for global health equity: the Lancet Commission on gender and global health" here:https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)00488-X/fulltext?dgcid=buzzsprout_tlv_podcast_lancetgenderhealth25_lancetSend us your feedback!Read all of our content at https://www.thelancet.com/?dgcid=buzzsprout_tlv_podcast_generic_lancetCheck out all the podcasts from The Lancet Group:https://www.thelancet.com/multimedia/podcasts?dgcid=buzzsprout_tlv_podcast_generic_lancetContinue this conversation on social!Follow us today at...https://thelancet.bsky.social/https://instagram.com/thelancetgrouphttps://facebook.com/thelancetmedicaljournalhttps://linkedIn.com/company/the-lancethttps://youtube.com/thelancettv

Neil Saravanamuttoo is the director of CitySHAPES. He was previously the chief economist of the G20's Global Infrastructure Hub and an executive in the Department of Finance Canada.CitySHAPES is working to make cities better by sparking and implementing the change they need to become healthier, greener, and more vibrant cities where everyone can thrive. They do this by working with partners in leading groundbreaking policy, advocacy, and community engagement work on key challenges faced by Canadian municipalities.Links:CitySHAPES: https://cityshapes.ca/BOOK Happy City by Charles Montgomery: https://happycities.com/the-bookBOOK The Miracle Pill by Peter Walker: https://www.indigo.ca/en-ca/the-miracle-pill/66a39acb-a0e9-333d-897d-f212ffcdcb70.htmlBOOK Broken City by Patrick M. Condon: https://www.ubcpress.ca/broken-cityBOOK Building the Cycling City by Melissa and Chris Bruntlett: https://urbancyclinginstitute.org/building-the-cycling-city-the-dutch-blueprint-for-urban-vitality/ARTICLE Suburban expansion costs increase to $465 per person per year in Ottawa: https://www.cbc.ca/news/canada/ottawa/urban-expansion-costs-menard-memo-1.6193429ARTICLE When Mothers are Active so are their Children: https://www.sciencedaily.com/releases/2014/03/140324090408.htmARTICLE The economic burden of physical inactivity: a global analysis of major non-communicable diseases: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(16)30383-X/abstract#au40ARTICLE The Price of Inactivity: Measuring the Powerful Impact of Sport, Physical Activity, and Recreation in Canada: https://measuring-impact.ca/wp-content/uploads/2023/11/CFLRI-CPRA_Price-Inactivity-Full-Report-EN-FINAL.pdfARTICLE Impact of minimum parking requirements for multi-family residential buildings on housing affordability and sustainability: https://assets.cmhc-schl.gc.ca/sf/project/archive/housing_organizations4/impact-of-parking-requirements-on-housing-affordability_final-report.pdf---- Please subscribe to the Sports for Social Impact Podcast wherever you get your podcast! Leave us a review and a 5 star rating to help bring others in the world of sports into the conversation! The Sports for Social Impact podcast was nominated for a Sports Podcast Award and Canadian Podcast Award.Send us an email at ⁠sportsforsocialimpact@gmail.com⁠ Linktree: ⁠https://linktr.ee/sportsforsocialimpact⁠Linkedin: ⁠https://www.linkedin.com/company/sports-for-social-impact⁠Follow us on Instagram (@SportsSocImpact) Visit our website at https://www.sportsforsocialimpact.com/

We've had many discussions about the technical aspects of vertebroplasty and kyphoplasty on BackTable MSK. However, in this episode, we take a deeper look into the history of these procedures, exploring early research controversies and the challenges that threatened their existence. Our host, Dr. Jacob Fleming, is joined in the BackTable Studio by interventional neuroradiologist Dr. Joshua Hirsch, who was in San Diego for the ASSR 2025 meeting. Dr. Hirsch is the Chief of the Interventional Spine Service at Massachusetts General Hospital. --- This podcast is supported by: Medtronic MVP https://www.medtronic.com/en-us/healthcare-professionals/products/spinal-orthopedic.html#aq=%40pagetype%3D%22product-model%22&cq=%40products_category%3D%22Spinal%20and%20orthopedic%22%20OR%20%40ontology_isa%3D%22Spinal%20and%20orthopedic%22 --- SYNPOSIS Dr. Hirsch begins by outlining the historical origins of radiologists using cement injection and how this practice evolved into vertebroplasty. He then highlights early research on the procedure, focusing on key 2009 NEJM papers that sparked both scientific and public controversy, leading to setbacks in research and disparities in access to life-changing care. Since that time, newer studies have demonstrated the clear benefits of spinal augmentation for patients with vertebral insufficiency fractures, including Dr. Hirsch's own research showing a mortality benefit compared to nonsurgical treatment. Overall, the doctors discuss how far this field has advanced and the exciting developments currently in progress. --- TIMESTAMPS 00:00 - Introduction 03:09 - Historical Origins of Vertebroplasty 07:08 - Development and Evolution of Vertebroplasty 10:21 - Controversy Over 2009 Randomized Control Trials 16:35 - Disparities in Access to Vertebroplasty 21:01 - Dr. Hirsch's Research on Mortality Benefit of Vertebroplasty 32:31 - Opportunities for Patient Education 35:29 - Vertebroplasty vs. Kyphoplasty 37:34 - Challenges in Research Interpretations and Insurance Coverage 42:26 - Future Directions in Vertebral Augmentation --- RESOURCES Percutaneous polymethylmethacrylate vertebroplasty in the treatment of osteoporotic vertebral body compression fractures: technical aspects (Jensen et al, 1997): https://pmc.ncbi.nlm.nih.gov/articles/PMC8337380/ Simplicity of randomized, controlled trials of percutaneous vertebroplasty (Hirsch et al, 2003): https://pubmed.ncbi.nlm.nih.gov/16880881/ INvestigational Vertebroplasty Efficacy and Safety Trial (INVEST): a randomized controlled trial of percutaneous vertebroplasty (Gray et al, 2007): https://pubmed.ncbi.nlm.nih.gov/18096050/ A randomized trial of vertebroplasty for painful osteoporotic vertebral fractures (Buchbinder et al, 2009): https://pubmed.ncbi.nlm.nih.gov/19657121/ A Randomized Trial of Balloon Kyphoplasty and Nonsurgical Management for Treating Acute Vertebral Compression Fractures (FREE) (Meirhaeghe et al, 2013): https://pmc.ncbi.nlm.nih.gov/articles/PMC3678891/ A Randomized Trial of Vertebroplasty for Osteoporotic Spinal Fractures (Kallmes et al, 2009): https://www.nejm.org/doi/full/10.1056/NEJMoa0900563 A Randomized Trial of Epidural Glucocorticoid Injections for Spinal Stenosis (Friedly et al, 2014): https://www.nejm.org/doi/full/10.1056/NEJMoa1313265 Safety and efficacy of vertebroplasty for acute painful osteoporotic fractures (VAPOUR): a multicentre, randomised, double-blind, placebo-controlled trial (Clark et al, 2016): https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(16)31341-1/abstract Number Needed to Treat with Vertebral Augmentation to Save a Life (Hirsch et al, 2020): https://pmc.ncbi.nlm.nih.gov/articles/PMC6975314/ Major Medical Outcomes With Spinal Augmentation vs Conservative Therapy (McCullough et al, 2013): https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/1710123 Harvey L. Neiman Policy Institute: https://www.neimanhpi.org/

Francis Couturaud joins Chloe Wilson of The Lancet to discuss the RENOVE trial, which looks at assessing the efficacy and safety of reduced-dose versus full-dose direct oral anticoagulants in patients in whom extended anticoagulation has been indicated.Read the full paper: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)02842-3/fulltext?dgcid=buzzsprout_icw_podcast_generic_lancetContinue this conversation on social!Follow us today at...https://twitter.com/thelancethttps://instagram.com/thelancetgrouphttps://facebook.com/thelancetmedicaljournalhttps://linkedIn.com/company/the-lancethttps://youtube.com/thelancettv

In part two of this two-part series, Dr. Andy Southerland and Dr. Seemant Chaturvedi discuss the PRESTIAGE-AF trial. Show references: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)00333-2/fulltext 

On today's Spotlight, we ask why runners are racing faster than ever? The same could also be said of cyclists, and we use an intriguing article by Amby Burfoot to explore and discuss the possible contributors, ranging from super shoes to the "Bannister effect". It leads us back to ground we've covered before (shoe tech, carbs), some areas we have yet to cover in detail (bicarbonate), and down some dark alleys that may contain the future (and possibly present) of doping methods.We also talk about technology in sport, and about which sports have seen the biggest, fastest leaps as a result of innovation, taking a quick tour of some other devices that have 'recalibrated' sporting performances and human limits.Finally, we discuss some of the science and performances in the Zwift Academy 2025, the latest iteration of a competition to identify and recruit aspirant cyclists into two professional cycling teams. We explore the tests used on the show, their value, and how hugely confounded the talent prediction is, even in a sport as measurable as cycling.Show notesAs mentioned, Discourse is where it all goes down, and here's where you click to become a member for a small monthly donation. Sign up as a Patron, and you'll have access to this community, and all the fascinating insights shared by fellow listenersLinksSean Ingle's article on that four-minute mile projectionAmby Burfoot's intriguing thought experiment canvassing opinion on what is driving faster running performancesThe paper mentioned on the show describing novel drugs to "manage classical heme disorders" - not a huge leap to performance enhancement, but the molecular switch approach to doping may be a concernThe podcast we once did on technology in sport - includes klapskates, swimsuits, and bicyclesThe BBC article on the increasing prevalence of obesity and overweightThe Lancet study described in the BBC articleThe first episode of the 2025 Zwift Academy, the rest can be found on the same channelSome normative power output from elite men, and elite women's cycling. Compare yourself to the pros. I'll put the summary tables up on Discourse for members Get bonus content on Patreon Hosted on Acast. See acast.com/privacy for more information.

We're thrilled to be joined for a special return to the topic of Cancer by our own magnificent editorial assistant, Deboki Chakravarti! We cover a ton in this beefy episode, so grab a snack, get comfy, and prepare to dive deep on a topic that's well worth the revisit. SciShow Tangents is on YouTube! Go to www.youtube.com/scishowtangents to check out this episode with the added bonus of seeing our faces! Head to www.patreon.com/SciShowTangents to find out how you can help support SciShow Tangents, and see all the cool perks you'll get in return, like bonus episodes and a monthly newsletter! A big thank you to Patreon subscriber Garth Riley for helping to make the show possible!And go to https://store.dftba.com/collections/scishow-tangents to buy some great Tangents merch!Follow us on Twitter @SciShowTangents, where we'll tweet out topics for upcoming episodes and you can ask the science couch questions! While you're at it, check out the Tangents crew on Twitter: Ceri: @ceriley Sam: @im_sam_schultz Hank: @hankgreen[Truth or Fail]Water-logged diaper scanshttps://www.nist.gov/pml/about-pml/pml-working-you/pml-working-you-archives/fighting-cancer-diapershttps://www.nist.gov/news-events/news/2017/11/how-disposable-diapers-can-improve-measurements-tumor-growthToothbrush cancer camerahttps://www.forbes.com/sites/rachelsandler/2022/09/22/why-billionaire-eric-schmidt-is-backing-a-high-school-senior-making-a-cancer-detecting-toothbrush-and-other-brilliant-teens/https://www.mayoclinic.org/medical-professionals/obstetrics-gynecology/news/a-substantial-step-toward-earlier-endometrial-cancer-detection/mac-20560620Cancer-cell kleenexhttps://www.statnews.com/2017/09/06/masspec-pen-cancer/[This or That: Researcher, Patient, or Both]Round 1 - Sister Mary Joseph Nodulehttps://www.sciencedirect.com/science/article/pii/S2468294222000089#sec0006https://link.springer.com/article/10.1007/s00261-016-1031-1https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(18)31864-6/abstractRound 2 - Trousseau sign of malignancyhttps://www.sciencedirect.com/science/article/pii/S2468294222000089#sec0002https://pmc.ncbi.nlm.nih.gov/articles/PMC1022062/Round 3 - AOH1996https://www.alexslemonade.org/blog/chance-meeting-leads-promising-cancer-treatmenthttps://pmc.ncbi.nlm.nih.gov/articles/PMC10592352/https://clinicaltrials.gov/study/NCT05227326Round 4 - Papanicolaou (Pap) testhttps://acsjournals.onlinelibrary.wiley.com/doi/10.1002/cncy.22734https://www.sciencedirect.com/science/article/abs/pii/S2213294514002178[Ask the Science Couch]Proposition 65 in the state of California & carcinogens in studieshttps://oehha.ca.gov/proposition-65/about-proposition-65https://oehha.ca.gov/proposition-65/proposition-65-listhttps://oehha.ca.gov/proposition-65/how-chemicals-are-added-proposition-65-listhttps://pmc.ncbi.nlm.nih.gov/articles/PMC6349368/https://link.springer.com/article/10.1007/s10311-023-01668-1https://www.cancer.gov/about-cancer/causes-prevention/risk/substances/wood-dust Patreon bonus: Treatments for different cancers and why there's no singular curehttps://www.cancer.gov/about-cancer/treatment/typeshttps://www.aacr.org/patients-caregivers/about-cancer/what-is-cancer/https://www.cancercenter.com/community/blog/2023/10/cancer-is-not-one-diseasehttps://medlineplus.gov/cancer.html[Butt One More Thing]A trained dog could sniff out colorectal cancer in poop sampleshttps://gut.bmj.com/content/60/6/814https://www.cshl.edu/the-doctor-will-sniff-you-now/

In this podcast recorded in early February, David Phizackerley and Julian Treadwell (DTB Associate Editor) provide an overview of the March 2025 issue of DTB. Julian talks about his work as an academic GP based at Bristol University. He explains why and how he developed the GP Evidence website (https://gpevidence.org/) as a resource for health professionals to use as part of a shared decision making process, and talks about the importance of providing patients with information on the absolute benefits and harms of different treatment options for long-term conditions.   The editorial discusses a paper published in The Lancet on the population-health impact of new drugs recommended by NICE and highlights the tension between NICE's role in ensuring that treatments are a cost-effective use of taxpayers' money and its role in championing the for-profit life-sciences - https://dtb.bmj.com/content/63/3/34. A DTB Select item summarises safety alerts issued by the US Food and Drug Administration and the European Medicines Agency on liver problems associated with fezolinetant (▼Veoza), a drug licensed for the treatment of moderate-to-severe vasomotor symptoms associated with the menopause - https://dtb.bmj.com/content/63/3/36. The main article provides an overview of systemic anticancer treatments and conventional cytotoxic drugs - https://dtb.bmj.com/content/63/3/37.   Links GP Evidence (https://gpevidence.org/)   Naci H, Murphy P, Woods B, et al. Population-health impact of new drugs recommended by the National Institute for Health and Care Excellence in England during 2000–20: a retrospective analysis. The Lancet 2025;405:50–60. (https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)02352-3/fulltext)    Please subscribe to the DTB podcast to get episodes automatically downloaded to your mobile device and computer. Also, please consider leaving us a review or a comment on the DTB Podcast iTunes podcast page. If you want to contact us please email dtb@bmj.com. Thank you for listening.

In part two of this two-part series, Dr. Vikram Karnik and Dr. Lorraine Kalia discuss the preclinical data and epidemiological data that led us to the phase three study on exenatide. Show reference: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)00161-8/abstract  

In part one of this two-part series, Dr. Vikram Karnik and Dr. Lorraine Kalia discuss recent clinical trials on exenatide as a disease-modifying therapy for Parkinson disease. Show reference: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)00161-8/abstract 

Dr. Greg Cooper and Prof. Gill Livingston discuss new hopeful evidence about dementia prevention, intervention, and care. Show reference: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)01296-0/abstract  

5 Jahre Corona - Was haben wir aus der Pandemie gelernt? Es wäre ein Fehler, Erkenntnisse aus der Covid-19-Pandemie direkt auf die nächste Krise zu übertragen, meint der Virologe Christian Drosten in dieser neuen Podcast-Staffel. Wie gut ist das Wissen über potenziell pandemische Erreger? Wo stehen wir bei einer nächsten Pandemie womöglich besser da? Daniela Remus und Korinna Hennig aus der NDR Info-Wissenschaftsredaktion sprechen in der ersten von zehn Folgen mit verschiedenen Wissenschaftlern darüber, wie die Forschung vorgeht, wenn ein Erreger mit Pandemiepotenzial nachgewiesen wird. Wo lauern die größten Bedrohungen? Kann die Diagnostik ihren großen Vorsprung aus der Corona-Pandemie weiter ausbauen? Es geht um potenzielle Pandemiekandidaten auf der WHO-Liste, die Gefahr durch klimasensitive Infektionen und lückenhafte Surveillancestrukturen weltweit. Mit den ExpertInnen Sandra Ciesek, Christian Drosten, Fabian Leendertz und Berit Lange. Autorinnen und Hosts: Daniela Remus und Korinna Hennig Story Editing: Katharina Mahrenholtz Producerinnen: Marion von Clarenau und Christine Dreyer. Produktion: NDR Info 2025 Förderatlas der Deutschen Forschungsgemeinschaft (auch zu Drittmittelquote): https://foerderatlas.dfg.de/wp-content/uploads/2024/11/foerderatlas_2024.pdf Netzwerk Universitätsmedizin: https://www.netzwerk-universitaetsmedizin.de/ WHO-Liste von Erregern mit Pandemiepotenzial: https://cdn.who.int/media/docs/default-source/consultation-rdb/prioritization-pathogens-v6final.pdf Modellierung zu Krankheitslast und Todesfällen durch Antiobiotika-Resistenzen: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)01867-1/fulltext Das Coronavirus-Update - Alle Folgen des Podcasts: https://www.ndr.de/nachrichten/info/podcast4684.html Podcast-Tipp - 11KM: der tagesschau-Podcast https://1.ard.de/11KM

January 23rd: Skin Hunters Brought to Light (2002) Those in the medical career are sworn to do no harm and try their best to save the lives of their patients. But, what if the deaths of these patients provided them with a payout? On January 23rd 2002 a newspaper brought to light a truly horrifying crime happening inside a Polish hospital. https://en.wikipedia.org/wiki/Skin_Hunters, https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(07)60254-2/fulltext Learn more about your ad choices. Visit megaphone.fm/adchoices

On today's show, we explore the undercounted death toll in Gaza and how the Lancet's research team has developed a system to evaluate a more realistic toll. We're in conversation with Francesco Checchi, an epidemiologist at the London School of Hygiene & Tropical Medicine who supervised and worked on statistical analysis for the Lancet's recently published study, called “Traumatic injury mortality in the Gaza Strip from Oct 7, 2023, to June 30, 2024: a capture–recapture analysis”. Read the Lancet study here: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)02678-3/fulltext — Subscribe to this podcast: https://plinkhq.com/i/1637968343?to=page Get in touch: lawanddisorder@kpfa.org Follow us on socials @LawAndDis: https://twitter.com/LawAndDis; https://www.instagram.com/lawanddis/ The post Gaza's Death Toll Undercounted w/ Lancet Researcher Francesco Checchi appeared first on KPFA.

This conversation kicks off a new series that takes a deep dive into anything blood-related. During this episode, Dr. Andrew Jenzer revisits the podcast alongside Dr. Maxwell Lloyd to demystify some of the key ideas underpinning hemostasis, coagulation, and PTT levels. Join us as we discuss helpful tools to navigate detection, monitoring, testing, and all the factors that may affect results. From PTT and D-Dimer testing to mixed testing options and thrombal elastography, we cover it all. Next, we get into abnormalities and all the elements to consider before going about an invasive surgery of this nation. We get into detail about Von Willebrand's disease and what testing can tell you, after considering why clinical history is specifically important for the treatment of bleeding issues. Lastly, we discuss OMS-specific hemostatic agents, and the impact of CRASH 1, 2, and 3 trials on how we implement TXA. Join us today to hear all this and more. Key Points From This Episode:Introducing Drs. Andrew Jenzer and Maxwell Lloyd.Dr. Jenzer's upcoming mock boards course for residents.The topic of this episode which kicks off a new series: blood and anything blood related.Differentiating between primary and secondary hemostasis. Understanding intrinsic and extrinsic pathways. Why all coagulation factors are ultimately made in the liver.The importance of interpreting the lab values.Using the WETT acronym in the context of anti-coagulation.Monitoring through PTT. D-Dimer testing and why it is so often misunderstood. What is essential to do when mixing tests together. Another test option: thrombal elastography.Thinking about the risks and benefits of stopping anticoagulation. Developing a schema to think about abnormalities. Understanding how to address Haemophilia A and B. Why clinical history is particularly important for bleeding issues.Demystifying Von Willebrand's disease and what testing can tell you. OMS-specific hemostatic agents, which ones work best, and more. CRASH 1, 2 and 3 trials and TXA. Links Mentioned in Today's Episode:Dr. Maxwell Lloyd on Google Scholar — https://scholar.google.com/citations?user=D0agka0AAAAJ Dr. Andrew Jenzer Email — andrew.jenzer@gmail.com Dr. Andrew Jenzer — https://surgery.duke.edu/profile/andrew-clark-jenzer CRASH-1 — https://pmc.ncbi.nlm.nih.gov/articles/PMC33506/ CRASH-2 — https://pmc.ncbi.nlm.nih.gov/articles/PMC4576020/ CRASH-3 — https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(19)32233-0/fulltext Everyday Oral Surgery Website — https://www.everydayoralsurgery.com/ Everyday Oral Surgery on Instagram — https://www.instagram.com/everydayoralsurgery/ Everyday Oral Surgery on Facebook — https://www.facebook.com/EverydayOralSurgery/ Dr. Grant Stucki Email — grantstucki@gmail.com Dr. Grant Stucki Phone — 720-441-6059

Where does power lie in global health? What are the historical and systemic barriers that perpetuate inequities, and what is the impact of political shifts towards nationalism?  Catherine Kyobutungi and Madhukar Pai join Gavin to talk about their recent Comment published in The Lancet, "Shifting power in global health will require leadership by the Global South and allyship by the Global North". Join us to learn about the challenges and opportunities for Global South leadership and the importance of redefining knowledge, success, and problem identification in global health.You can read Catherine and Madhu's Comment piece here:https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)02323-7/fulltext?dgcid=buzzsprout_tlv_podcast_generic_lancetSend us your feedback!Read all of our content at https://www.thelancet.com/?dgcid=buzzsprout_tlv_podcast_generic_lancetCheck out all the podcasts from The Lancet Group:https://www.thelancet.com/multimedia/podcasts?dgcid=buzzsprout_tlv_podcast_generic_lancetContinue this conversation on social!Follow us today at...https://twitter.com/thelancethttps://instagram.com/thelancetgrouphttps://facebook.com/thelancetmedicaljournalhttps://linkedIn.com/company/the-lancethttps://youtube.com/thelancettv

The last Lancet Voice of the year delves into the latest findings from the Institute for Health Metrics and Evaluation (IHME) from our recently released US Special Issue. Ali Mokdad and Emmanuela Gakidou join Miriam Sabin and Gavin Cleaver to explore the comprehensive analysis of the Global Burden of Disease, the alarming trends in obesity and life expectancy, and the critical need for policy changes to improve public health in the United States.Read the US special issue here:https://www.thelancet.com/journals/lancet/issue/vol404no10469/PIIS0140-6736(24)X0050-1?dgcid=buzzsprout_tlv_podcast_generic_lancetSend us your feedback!Read all of our content at https://www.thelancet.com/?dgcid=buzzsprout_tlv_podcast_generic_lancetCheck out all the podcasts from The Lancet Group:https://www.thelancet.com/multimedia/podcasts?dgcid=buzzsprout_tlv_podcast_generic_lancetContinue this conversation on social!Follow us today at...https://twitter.com/thelancethttps://instagram.com/thelancetgrouphttps://facebook.com/thelancetmedicaljournalhttps://linkedIn.com/company/the-lancethttps://youtube.com/thelancettv

The US election has happened and fascism won at the ballot box.  It's time to get to work on what can best sustain the Pagan, Heathen, and Witch movements in the days ahead and help build a better world for all.  Join your host for a walk through what can be done and where we can go from here.COVID-19*https://www.who.int/data/stories/the-true-death-toll-of-covid-19-estimating-global-excess-mortality*https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)00493-2/fulltext*https://www.weforum.org/stories/2020/10/the-rich-got-richer-during-the-pandemic-and-that-s-a-daunting-sign-for-our-recovery/Discourse Forum Software*https://www.discourse.org/Margaret Killjoy*https://margaretkilljoy.substack.com/p/the-sky-is-falling-weve-got-thisSunrise Movement*https://www.commondreams.org/news/trump-on-climate-changeNever Again Action*https://www.neveragainaction.com/

#cuttheclutter From cracker ban to odd-even and smog towers, the bid to curb air pollution levels in North India have led to the creation of a thriving ‘we must do something' industrial complex. In Episode 1545 of Cut The Clutter, Editor-in-Chief Shekhar Gupta explains the seriousness of the problem and why efforts to address it have come to naught. -------------------------------------------------------------------------------------- To read National Interest Article: https://theprint.in/national-interest/delhi-air-will-something/13029/ --------------------------------------------------------------------------------------------- To read Lancet Report : https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)01822-1/abstract --------------------------------------------------------------------------------------------- To read EPCA February, 2017 Report: https://www.epca.org.in/EPCA-Reports1999-1917/Report-no.65.pdf --------------------------------------------------------------------------------------------- To read EPCA April, 2017 Report: https://www.epca.org.in/EPCA-Reports1999-1917/Final-EPCA-Report-71-CAP-for-Delhi-NCR.pdf ---------------------------------------------------------------------------------------------  @arvindmenswear66  This Season, Embrace Royalty & Legacy with our New Season Launch of Luxury Primante Collection Fabrics. Discover our latest showcase featuring the esteemed People's Prince, Dr. Lakshyaraj Singh Mewar. Own your day, visit your nearest Arvind Store and craft your perfect look. #TheArvindStore #OwnYourLegacy #OwnTheMoment https://tinyurl.com/3wa2zatn

Send us a textWatch On The Pen Live:onthepen.tvGLP-1 News:onthepen.comSPONSOR:Ro.Co/OTPSHOW NOTESWEGOVY REDUCES COVID DEATHShttps://www.wjbf.com/news/popular-weight-loss-drug-reduced-risk-of-covid-deaths-in-new-study/WEGOVY REDUCES HEART DISEASE RISK BY 20%https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)01498-3/fulltextOZEMPIC SHORTAGE TO LAST THROUGH 2024https://www.biospace.com/business/novos-ozempic-to-remain-in-shortage-into-q4-as-supply-woes-continueSupport the Show.MY WORK RELIES ON YOUR GENEROSITY, WAYS TO SUPPORT:Venmo: OnThePenCa$h App: ManOnMounjaroBECOME A MEMBER:https://www.youtube.com/channel/UCDocQ-4IhVS3ihy_dW7nSKw/joinSOCIAL LINKShttps://www.tiktok.com/@manonthemounjarohttps://twitter.com/ManOnMounjarohttps://instagram.com/manonthemounjarohttps://facebook.com/manonthemounjaro

In this episode, we discuss updates on low-risk MDS with Dr. Maximilian Stahl with a focus on imetelstat and luspatercept. Here are the trials we discussed: 1. IWG 2019 response criteriahttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042664/ 2. MEDALIST trial: Luspatercepthttps://www.nejm.org/doi/10.1056/NEJMoa1908892?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed 3. COMMANDS trial : Luspatercept https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)00874-7/abstracthttps://www.thelancet.com/journals/lanhae/article/PIIS2352-3026(24)00203-5/abstract 4. IMerge trial: Imetelstat https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)01724-5/abstract  

The use of drug-coated balloons (DCBs) for peripheral arterial disease has been controversial in the past. However, new data and updated FDA guidance have helped these devices regain popularity. In this episode of the BackTable Podcast, Dr. Ally Baheti hosts a discussion with Dr. Sahil Parikh, an interventional cardiologist in New York City, and Dr. John Park, a vascular surgeon in Omaha. --- CHECK OUT OUR SPONSOR BD Lutonix https://www.bd.com/en-us/products-and-solutions/products/product-families/lutonix-drug-coated-balloon-pta-catheters --- SYNPOSIS They review the historical controversy surrounding the potential late-mortality risks associated with Paclitaxel-coated devices, discuss more recent literature on the safety and efficacy of DCBs, and examine the implications of the FDA's updated guidance in 2023. This update was made possible through collaborative efforts across specialties and regulatory bodies to establish best practices for vascular interventions. They also delve into patient selection criteria, lesion characteristics, and practical considerations for choosing between DCBs and other revascularization options. Each provider shares their treatment algorithm for DCB use in peripheral arterial disease. Dr. Park uses DCBs as a first-line treatment for patients with complete occlusions, CLTI symptoms, or lifestyle-limiting claudication, with adjunctive stenting sometimes required afterwards. In his experience, DCBs work best in lesions shorter than 100 mm and are preferable in locations where stenting is not feasible, such as across the knee joint. Dr. Parikh similarly prefers DCBs over plain balloon angioplasty and places stents in longer lesions. He notes that Hunter's canal is a challenging area to treat with DCBs alone and may require atherectomy or intravascular lithotripsy. He recommends considering drug-eluting stents as a proactive measure to prevent more costly interventions for future restenosis. --- TIMESTAMPS 00:00 - Introduction 02:14 - History of DCB and Controversy 07:46 - Updated Research and 2023 FDA Guidelines 16:44 - Importance of Collaboration and Patient Preference 26:34 - DCB Treatment Algorithms 33:31 - Drug-Eluting Stents 35:46 - Approach for Patients with Claudication 37:22 - DCB Sizing and Dose --- RESOURCES Risk of Death Following Application of Paclitaxel‐Coated Balloons and Stents in the Femoropopliteal Artery of the Leg: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials (2018): https://www.ahajournals.org/doi/10.1161/JAHA.118.011245 FDA- Treatment of Peripheral Arterial Disease with Paclitaxel-Coated Balloons and Paclitaxel-Eluting Stents Potentially Associated with Increased Mortality–Letter to Health Care Providers (2018): www.fda.gov/medical-devices/letters-health-care-providers/update-treatment-peripheral-arterial-disease-paclitaxel-coated-balloons-and-paclitaxel-eluting FDA- Paclitaxel-Coated Devices to Treat Peripheral Arterial Disease Unlikely to Increase Risk of Mortality - Letter to Health Care Providers (2023): https://www.fda.gov/medical-devices/letters-health-care-providers/update-paclitaxel-coated-devices-treat-peripheral-arterial-disease-unlikely-increase-risk-mortality Mortality in randomised controlled trials using paclitaxel-coated devices for femoropopliteal interventional procedures: an updated patient-level meta-analysis (2023): https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)02189-X/abstract

14 modifiable risk factors account for 45% of dementia cases worldwide. Gavin and Jessamy are joined by Prof. Gill Livingston (UCL) and Prof. Geir Selbaek (University of Oslo) to discuss the 2024 updates to The Lancet Commission on dementia prevention.You can read the Commission here:https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)01296-0?dgcid=buzzsprout_tlv_podcast_generic_lancetSend us your feedback!Continue this conversation on social!Follow us today at...https://twitter.com/thelancethttps://instagram.com/thelancetgrouphttps://facebook.com/thelancetmedicaljournalhttps://linkedIn.com/company/the-lancethttps://youtube.com/thelancettv

On this week's Access Hour, we bring you the fourth pilot of a new program here on Forward Radio, Sacrifice Zones, hosted by Stretch. Tune in for an update to Dr. Lina Yassine's report a few weeks ago on the Access Hour. Lina is a Louisville endocrinologist who just returned from Jordan, where she was born. The title of her presentation is "No One, Nowhere, Is Safe In Gaza." Following the interview, Stretch sits down with fellow programmer Bob Cline to discuss the situation in Gaza and how it relates to inequities right here in the U.S. We all live in a Sacrifice Zone, separated only by how well insulated we are in settler colonial projects. Dr. Lina Yassine is a Palestinian who was born as a refugee in Jordan. She obtained her medical degree from the University of Jordan Medical school in Amman. She later on completed an internal Medicine residency and an Endocrinology fellowship at Henry Ford Hospital in Detroit, Michigan. She is currently practicing Endocrinology in Louisville, Kentucky, and is sometimes referred to as the sugar doctor. Please find below, some resources for further reading from Dr. Lina Yassine's presentation on 7/13/24: https://www.democracynow.org/2024/6/28/headlines/house_of_representatives_votes_269_144_to_ban_state_department_from_citing_gaza_death_toll Rashida Talib's reading into the Congressional Record of Palestinians killed and the al-Mawasi refugee shelter attack https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)01169-3/fulltext Counting the Dead: Difficult But Essential https://www.doctorswithoutborders.ca/strikes-raids-and-incursions-seven-months-of-relentless-attacks-on-healthcare-in-palestine/

WE NEED YOU TO LOCK IN. The HITO boys cover the Trump assassination attempt, Biden's refusal to step down, and get back to our roots with updates on the situation in Gaza and France (francophobic). If you enjoy the show, make sure to check out the Patreon, follow us on social media, and leave a 5-star review on Apple.  Get 15% off of Ground News: check.ground.news/headintheoffice HITO MERCH: https://headintheoffice.com/  Patreon: https://www.patreon.com/headintheofficepod YouTube: https://www.youtube.com/channel/UC4iJ-UcnRxYnaYsX_SNjFJQ TikTok: https://www.tiktok.com/@headintheoffice?lang=en Instagram: https://www.instagram.com/headintheoffice/ Twitter: https://twitter.com/headintheoffice Discord: https://discord.gg/hito  Collab inquiries: headintheofficepod@gmail.com REGISTER TO VOTE: www.vote.org  Seen on this episode: Trump Assassination Attempt -  https://www.nbcnews.com/news/us-news/live-blog/donald-trump-shooting-live-updates-assassination-attempt-shock-biden-rcna161759 More Democrats call on Biden to drop out - https://www.cnbc.com/2024/07/12/biden-live-updates-democrats-trump-election.html  Biden's polling -  https://projects.fivethirtyeight.com/biden-approval-rating/  https://www.npr.org/2024/07/12/nx-s1-5036518/biden-trump-poll  https://thehill.com/homenews/campaign/4762860-democrats-lose-ground-post-debate-election-forecaster/  https://www.nbcnews.com/politics/2024-election/poll-debate-aftermath-damages-biden-democratic-party-matchup-trump-unc-rcna161154 Israel & Gaza news - https://www.bbc.com/news/articles/cyx0qdkn45eo  https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)01169-3/fulltext  French elections - https://www.cnn.com/2024/07/08/europe/france-election-what-next-explainer-intl/index.html  https://www.foxnews.com/world/israeli-minister-touts-marine-le-pen-excellent-option-french-president-exclamation-marks  https://apnews.com/article/france-election-le-pen-national-rally-antisemitism-cd02c4c834a69430e3194ec7629f36f9  Seen on this episode: Trump Assassination Attempt -  https://www.nbcnews.com/news/us-news/live-blog/donald-trump-shooting-live-updates-assassination-attempt-shock-biden-rcna161759 More Democrats call on Biden to drop out - https://www.cnbc.com/2024/07/12/biden-live-updates-democrats-trump-election.html  Biden's polling -  https://projects.fivethirtyeight.com/biden-approval-rating/  https://www.npr.org/2024/07/12/nx-s1-5036518/biden-trump-poll  https://thehill.com/homenews/campaign/4762860-democrats-lose-ground-post-debate-election-forecaster/  https://www.nbcnews.com/politics/2024-election/poll-debate-aftermath-damages-biden-democratic-party-matchup-trump-unc-rcna161154 Israel & Gaza news - https://www.bbc.com/news/articles/cyx0qdkn45eo  https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)01169-3/fulltext  French elections - https://www.cnn.com/2024/07/08/europe/france-election-what-next-explainer-intl/index.html  https://www.foxnews.com/world/israeli-minister-touts-marine-le-pen-excellent-option-french-president-exclamation-marks  https://apnews.com/article/france-election-le-pen-national-rally-antisemitism-cd02c4c834a69430e3194ec7629f36f9 

In this episode, we reviewed the hottest updates in lymphoma from ASCO and EHA 2024, held in Chicago and Madrid respectively, with Dr. Gloria Iacoboni, a haematologist from University Hospital Vall d'Hebron, in Barcelona, Spain. Here are the key abstracts we discussed: 1.      STARGLO: Glofit-GEMOX vs R-GEMOX in relapsed/refractory DLBCLhttps://library.ehaweb.org/eha/2024/eha2024-congress/4136516 2.     Epco-Pola-R-CHP for 1st line DLBCL (EPCORE NHL-5 study):https://library.ehaweb.org/eha/2024/eha2024-congress/422343 3.     3-year follow-up of TRANSFORM (Liso-Cel vs CITàASCT in R/R DLBCL): https://meetings.asco.org/abstracts-presentations/232740 4.     ECHO RCT: Acalabrutinib-BR vs Placebo-BR in previously untreated elderly MCL: https://library.ehaweb.org/eha/2024/eha2024-congress/4136515 5.     HD21: escBEACOPP vs BrECADD in 1st line classical HL: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)01315-1/fulltext 6.     Combination pirtobrutinib, venetoclax, and obinutuzumab in 1st line CLL: https://library.ehaweb.org/eha/2024/eha2024-congress/422268 7.      Single-agent epcoritamab in Richter's transformation: EPCORE CLL-1: https://library.ehaweb.org/eha/2024/eha2024-congress/422267

En este episodio de Doctor Mau Informa, exploramos los remedios naturales más efectivos para combatir la presión arterial elevada. Descubre cómo ciertos alimentos y cambios en el estilo de vida pueden ayudarte a mantener tu presión arterial bajo control de manera natural y segura. ¡No te pierdas estos valiosos consejos para mejorar tu salud cardiovascular! Suscríbete a mi boletín informativo en www.drmauriciogonzalez.com Sígueme en: YouTube: www.youtube.com/@doctormauinforma Instagram: www.instagram.com/dr.mauriciogonzalez/ TikTok: www.tiktok.com/@drmauriciogonzalez Twitter: www.twitter.com/DrMauricioGon CONTACTO ► booking@drmauriciogonzalez.com Fuentes:  World Health Organization (WHO). Hypertension. (https://www.who.int/news-room/fact-sheets/detail/hypertension) American Heart Association (AHA). Hypertension. https://www.heart.org/en/health-topics/high-blood-pressure) Alzheimer's Association. https://www.alz.org/blog/alz/september-2020/can-certain-healthy-habits-throughout-each-stage-o Blood Pressure UK. Benefits of Lowering Your Blood Pressure. [Blood Pressure UK](https://www.bloodpressureuk.org/your-blood-pressure/treating-high-blood-pressure/benefits-of-lowering-your-blood-pressure) American Heart Association (AHA). Understanding Blood Pressure Readings. https://www.heart.org/en/health-topics/high-blood-pressure/understanding-blood-pressure-readings https://www.sciencedirect.com/science/article/abs/pii/S1262363619300850?via%3Dihub https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(19)30041-8/fulltext https://journals.lww.com/jhypertension/fulltext/2024/01000/lifestyle_management_of_hypertension_.3.aspx Learn more about your ad choices. Visit megaphone.fm/adchoices

Há muitos mitos e tabus acerca da famosa Cannabis, essa plantinha cujo uso acontece há milhares de anos. Mas, afinal, o que a ciência já sabe sobre a maconha? Tinha que ser em duas partes! Aqui, a parte 2 de 2.Confira a segunda (e última) parte do papo entre o leigo curioso, Ken Fujioka, e o cientista PhD, Altay de Souza.> OUÇA (46min 36s)*Naruhodo! é o podcast pra quem tem fome de aprender. Ciência, senso comum, curiosidades, desafios e muito mais. Com o leigo curioso, Ken Fujioka, e o cientista PhD, Altay de Souza.Edição: Reginaldo Cursino.http://naruhodo.b9.com.br*REFERÊNCIASThe relationship between cannabis use, schizophrenia, and bipolar disorder: a genetically informed studyhttps://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(23)00143-8/abstractDoes a history of cannabis use influence onset and course of schizophrenia?https://onlinelibrary.wiley.com/doi/full/10.1111/acps.13562Cannabis and schizophrenia: A complex relationshiphttps://cdn.mdedge.com/files/s3fs-public/CP02212043.pdfCannabis use in Attention – Deficit/Hyperactivity Disorder (ADHD): A scoping reviewhttps://www.sciencedirect.com/science/article/pii/S0022395622006549?casa_token=sBTLU5vfSxkAAAAA:ilKFmuKH2GQG9ylQZoK0WVi9qdlaWwSZl3L4n4o4VUpSZFtzdpPHt3loJJBzwVl3XKEaSyYVOgPrenatal cannabis use and the risk of attention deficit hyperactivity disorder and autism spectrum disorder in offspring: A systematic review and meta-analysishttps://www.sciencedirect.com/science/article/pii/S0022395624000591Exploring the Link between ADHD and Cannabis Use in Swedish Ninth Graders: The Role of Conduct Problems and Sensation-Seekinghttps://www.tandfonline.com/doi/full/10.1080/10826084.2022.2155478UK Medical Cannabis Registry: An analysis of clinical outcomes of medicinal cannabis therapy for attention-deficit/hyperactivity disorderhttps://onlinelibrary.wiley.com/doi/full/10.1002/npr2.12400Associations of cannabis use, use frequency, and cannabis use disorder with violent behavior among young adults in the United Stateshttps://www.sciencedirect.com/science/article/pii/S0955395924001166?casa_token=ODtslt9jke0AAAAA:-uxBbGJnqrra1ax1jysPu6ki-EiFxh-ZvU9tVT0YFSwwnhmmpUNrh5snI5al-CUBUA8xDBEBoAAssociation Between Cannabis and Violence in Community-Dwelling Patients With Severe Mental DisordersA Cross-sectional Study Using Machine Learninghttps://journals.lww.com/jonmd/abstract/2023/02000/association_between_cannabis_and_violence_in.2.aspx?context=latestarticlesEdible Cannabis Legalization and Cannabis Poisonings in Older Adultshttps://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2818635Plantations Beyond Monocrops: Cannabis Ecologies From Colonial Angola to São Toméhttps://journals.sagepub.com/doi/full/10.1177/02780771231222335Cannabidiol (CBD) and its analogs: a review of their effects on inflammationhttps://nida.nih.gov/publications/drugfacts/cannabis-marijuana“Do You Need Someone to Share With?”: Exchange and Demand Sharing in Social Cannabis Supplyhttps://journals.sagepub.com/doi/full/10.1177/00914509221146794Consuming unregulated “diet weed”: The social context of motivations and risk among users of Delta-8 THChttps://anthrosource.onlinelibrary.wiley.com/doi/abs/10.1111/napa.12211Examining the effect of cannabis cues on cannabis demand in sleep, driving, and typical drug-use contextshttps://www.sciencedirect.com/science/article/pii/S0376871623012954?casa_token=XiUEz9zkGV8AAAAA:aDWrpxsa5V7hO3RKEmbIO_V-7nSihgxXgOgJIRGfepldc2kRY3aYNtHs0RbqIdYdVmZmBe8cqwCritical chemsex studies: Interrogating cultures of sexualized drug use beyond the risk paradigmhttps://journals.sagepub.com/doi/full/10.1177/13634607211026223Culturally tailored substance use interventions for Indigenous people of North America: a systematic reviewhttps://www.emerald.com/insight/content/doi/10.1108/JMHTEP-07-2021-0088/full/htmlDevelopment of a rational scale to assess the harm of drugs of potential misusehttps://www.thelancet.com/journals/lancet/article/PIIS0140-6736(07)60464-4/abstractAdverse effects of medical cannabinoids: a systematic reviewhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2413308/Gut microbiome and metabolomic profiles reveal the antiatherosclerotic effect of indole-3-carbinol in high-choline-fed ApoE-/- micehttps://www.sciencedirect.com/science/article/pii/S0944711324002800?via%3Dihub#bib0028Table 3 Anti-tumor activities of I3C and DIM compoundshttps://cancerci.biomedcentral.com/articles/10.1186/s12935-023-03031-4/tables/3Cannabinoids in medicine: A review of their therapeutic potentialhttps://web.archive.org/web/20100524141419/http://www.doctordeluca.com/Library/WOD/WPS3-MedMj/CannabinoidsMedMetaAnalysis06.pdfDread : the Rastafarians of Jamaicahttps://archive.org/details/dreadrastafarian00owenNaruhodo #371 - Qual o impacto do alcoolismo nos dias de hoje? - Parte 1 de 2https://www.youtube.com/watch?v=JAIjJ6E8ZHkNaruhodo #372 - Qual o impacto do alcoolismo nos dias de hoje? - Parte 2 de 2https://www.youtube.com/watch?v=ZRwC2GQevIoNaruhodo #49 - O que causa o vício?https://www.youtube.com/watch?v=--Z_ylPXIWcNaruhodo #207 - Vape e cigarro eletrônico são seguros?https://www.youtube.com/watch?v=Raa9CUrIFbsNaruhodo #85 - Por que é tão difícil parar de fumar?https://www.youtube.com/watch?v=SPkIT0ehoisNaruhodo #267 - O que é dissonância cognitiva? - Parte 1 de 2https://www.youtube.com/watch?v=1xJwqmir5UwNaruhodo #268 - O que é dissonância cognitiva? - Parte 2 de 2https://www.youtube.com/watch?v=--OHlHmOQTM*APOIE O NARUHODO PELA PLATAFORMA ORELO!O podcast Naruhodo está no Orelo: bit.ly/naruhodo-no-oreloE é por meio dessa plataforma de apoio aos criadores de conteúdo que você ajuda o Naruhodo a se manter no ar.Você escolhe um valor de contribuição mensal e tem acesso a conteúdos exclusivos, conteúdos antecipados e vantagens especiais.Além disso, você pode ter acesso ao nosso grupo fechado no Telegram, e conversar comigo, com o Altay e com outros apoiadores.E não é só isso: toda vez que você ouvir ou fizer download de um episódio pelo Orelo, vai também estar pingando uns trocadinhos para o nosso projeto.Então, baixe agora mesmo o app Orelo no endereço Orelo.CC ou na sua loja de aplicativos e ajude a fortalecer o conhecimento científico.bit.ly/naruhodo-no-orelo

*Content warning: child abuse, sexual abuse, pedophilia, medical child abuse, Factitious disorder imposed on another, Munchausen by proxy, psychological, emotional, mental, and physical abuse. Thank you Andrea Dunlop for partnering with us for this special educational Data Points episode!Andrea's website:https://www.andreadunlop.net/Andrea's books:https://www.andreadunlop.net/booksNobody Should Believe Me podcast:https://www.nobodyshouldbelieveme.com/Munchausen Support website:https://www.munchausensupport.com/*Sources:The Power of Labels via The Lancethttps://www.thelancet.com/journals/lancet/article/PIIS0140-6736(04)17007-4/fulltextEpidemiology and evolution of the diagnostic classification of factitious disorders in DSM-5:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729833/First Uses of the Term Munchausen by Proxy:https://pubmed.ncbi.nlm.nih.gov/26372976/Munchausen syndrome by Proxy rates:https://pubmed.ncbi.nlm.nih.gov/8608388/#:~:text=The%20estimated%20mortality%20rate%20of,by%20proxy%20is%209%20percent.MBP Clinical & Case Management Guidance by APSAC:https://apsac.org/wp-content/uploads/2023/05/Munchausen-by-Proxy-Clinical-and-Case-Management-Guidance-.pdfFeldman, K.W., Ambartsumyan, L., Goldin, A., Jenny, C., Wiester, R.T., Metz, J.B.et al. (2022) Gastrointestinal problems and non-Oral feeding in children evaluated for medical child abuse (fabricated and induced illness). Child Abuse Review, e2746. Available from: https://doi.org/10.1002/car.2746*Resources: Munchausen Supporthttps://www.munchausensupport.com/Marc Feldman's website/bookshttp://www.munchausen.comAmerican Professional Society on the Abuse of Childrenhttps://apsac.org/For a comprehensive list of non-profit organizations and resources, please visit somethingwaswrong.com/resources See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Há muitos mitos e tabus acerca da famosa Cannabis, essa plantinha cujo uso acontece há milhares de anos. Mas, afinal, o que a ciência já sabe sobre a maconha? Tinha que ser em duas partes! Aqui, a parte 1 de 2.Confira a primeira parte (de duas) do papo entre o leigo curioso, Ken Fujioka, e o cientista PhD, Altay de Souza.> OUÇA (53min 20s)*Naruhodo! é o podcast pra quem tem fome de aprender. Ciência, senso comum, curiosidades, desafios e muito mais. Com o leigo curioso, Ken Fujioka, e o cientista PhD, Altay de Souza.Edição: Reginaldo Cursino.http://naruhodo.b9.com.br*REFERÊNCIASThe relationship between cannabis use, schizophrenia, and bipolar disorder: a genetically informed studyhttps://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(23)00143-8/abstractDoes a history of cannabis use influence onset and course of schizophrenia?https://onlinelibrary.wiley.com/doi/full/10.1111/acps.13562Cannabis and schizophrenia: A complex relationshiphttps://cdn.mdedge.com/files/s3fs-public/CP02212043.pdfCannabis use in Attention – Deficit/Hyperactivity Disorder (ADHD): A scoping reviewhttps://www.sciencedirect.com/science/article/pii/S0022395622006549?casa_token=sBTLU5vfSxkAAAAA:ilKFmuKH2GQG9ylQZoK0WVi9qdlaWwSZl3L4n4o4VUpSZFtzdpPHt3loJJBzwVl3XKEaSyYVOgPrenatal cannabis use and the risk of attention deficit hyperactivity disorder and autism spectrum disorder in offspring: A systematic review and meta-analysishttps://www.sciencedirect.com/science/article/pii/S0022395624000591Exploring the Link between ADHD and Cannabis Use in Swedish Ninth Graders: The Role of Conduct Problems and Sensation-Seekinghttps://www.tandfonline.com/doi/full/10.1080/10826084.2022.2155478UK Medical Cannabis Registry: An analysis of clinical outcomes of medicinal cannabis therapy for attention-deficit/hyperactivity disorderhttps://onlinelibrary.wiley.com/doi/full/10.1002/npr2.12400Associations of cannabis use, use frequency, and cannabis use disorder with violent behavior among young adults in the United Stateshttps://www.sciencedirect.com/science/article/pii/S0955395924001166?casa_token=ODtslt9jke0AAAAA:-uxBbGJnqrra1ax1jysPu6ki-EiFxh-ZvU9tVT0YFSwwnhmmpUNrh5snI5al-CUBUA8xDBEBoAAssociation Between Cannabis and Violence in Community-Dwelling Patients With Severe Mental DisordersA Cross-sectional Study Using Machine Learninghttps://journals.lww.com/jonmd/abstract/2023/02000/association_between_cannabis_and_violence_in.2.aspx?context=latestarticlesEdible Cannabis Legalization and Cannabis Poisonings in Older Adultshttps://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2818635Plantations Beyond Monocrops: Cannabis Ecologies From Colonial Angola to São Toméhttps://journals.sagepub.com/doi/full/10.1177/02780771231222335Cannabidiol (CBD) and its analogs: a review of their effects on inflammationhttps://nida.nih.gov/publications/drugfacts/cannabis-marijuana“Do You Need Someone to Share With?”: Exchange and Demand Sharing in Social Cannabis Supplyhttps://journals.sagepub.com/doi/full/10.1177/00914509221146794Consuming unregulated “diet weed”: The social context of motivations and risk among users of Delta-8 THChttps://anthrosource.onlinelibrary.wiley.com/doi/abs/10.1111/napa.12211Examining the effect of cannabis cues on cannabis demand in sleep, driving, and typical drug-use contextshttps://www.sciencedirect.com/science/article/pii/S0376871623012954?casa_token=XiUEz9zkGV8AAAAA:aDWrpxsa5V7hO3RKEmbIO_V-7nSihgxXgOgJIRGfepldc2kRY3aYNtHs0RbqIdYdVmZmBe8cqwCritical chemsex studies: Interrogating cultures of sexualized drug use beyond the risk paradigmhttps://journals.sagepub.com/doi/full/10.1177/13634607211026223Culturally tailored substance use interventions for Indigenous people of North America: a systematic reviewhttps://www.emerald.com/insight/content/doi/10.1108/JMHTEP-07-2021-0088/full/htmlDevelopment of a rational scale to assess the harm of drugs of potential misusehttps://www.thelancet.com/journals/lancet/article/PIIS0140-6736(07)60464-4/abstractAdverse effects of medical cannabinoids: a systematic reviewhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2413308/Gut microbiome and metabolomic profiles reveal the antiatherosclerotic effect of indole-3-carbinol in high-choline-fed ApoE-/- micehttps://www.sciencedirect.com/science/article/pii/S0944711324002800?via%3Dihub#bib0028Table 3 Anti-tumor activities of I3C and DIM compoundshttps://cancerci.biomedcentral.com/articles/10.1186/s12935-023-03031-4/tables/3Cannabinoids in medicine: A review of their therapeutic potentialhttps://web.archive.org/web/20100524141419/http://www.doctordeluca.com/Library/WOD/WPS3-MedMj/CannabinoidsMedMetaAnalysis06.pdfDread : the Rastafarians of Jamaicahttps://archive.org/details/dreadrastafarian00owenNaruhodo #371 - Qual o impacto do alcoolismo nos dias de hoje? - Parte 1 de 2https://www.youtube.com/watch?v=JAIjJ6E8ZHkNaruhodo #372 - Qual o impacto do alcoolismo nos dias de hoje? - Parte 2 de 2https://www.youtube.com/watch?v=ZRwC2GQevIoNaruhodo #49 - O que causa o vício?https://www.youtube.com/watch?v=--Z_ylPXIWcNaruhodo #207 - Vape e cigarro eletrônico são seguros?https://www.youtube.com/watch?v=Raa9CUrIFbsNaruhodo #85 - Por que é tão difícil parar de fumar?https://www.youtube.com/watch?v=SPkIT0ehoisNaruhodo #267 - O que é dissonância cognitiva? - Parte 1 de 2https://www.youtube.com/watch?v=1xJwqmir5UwNaruhodo #268 - O que é dissonância cognitiva? - Parte 2 de 2https://www.youtube.com/watch?v=--OHlHmOQTM*APOIE O NARUHODO PELA PLATAFORMA ORELO!O podcast Naruhodo está no Orelo: bit.ly/naruhodo-no-oreloE é por meio dessa plataforma de apoio aos criadores de conteúdo que você ajuda o Naruhodo a se manter no ar.Você escolhe um valor de contribuição mensal e tem acesso a conteúdos exclusivos, conteúdos antecipados e vantagens especiais.Além disso, você pode ter acesso ao nosso grupo fechado no Telegram, e conversar comigo, com o Altay e com outros apoiadores.E não é só isso: toda vez que você ouvir ou fizer download de um episódio pelo Orelo, vai também estar pingando uns trocadinhos para o nosso projeto.Então, baixe agora mesmo o app Orelo no endereço Orelo.CC ou na sua loja de aplicativos e ajude a fortalecer o conhecimento científico.bit.ly/naruhodo-no-orelo

In this episode, Dr. Ally Baheti interviews interventional radiologist Dr. Lorenzo Patrone about his recent multidisciplinary editorial entitled "The 'Woundosome' Concept and Its Impact on Procedural Outcomes in Patients With Chronic Limb-Threatening Ischemia.” --- CHECK OUT OUR SPONSOR Reflow Medical https://www.reflowmedical.com/ --- SYNPOSIS Dr. Patrone explains his interest in critical limb ischemia (CLI) and describes how he reached out to colleagues around the world with the intention of drafting a paper that summarizes research in below-the-ankle interventions and increases awareness of the woundosome concept. He explains the woundosome concept, which aims to understand how each patient's foot vasculature influences the effectiveness of below-the-ankle interventions and tissue healing. Understanding each patient's anatomy, having adequate imaging of the foot, obtaining pedal acceleration times, and using micro-oxygen sensors are strategies to assess wound perfusion, which is integral for treatment planning and prognosis. He illustrates these techniques in a case study of a non-healing wound. Finally, Dr. Patrone shares some technical tips for below-the-ankle interventions, including the benefits of ipsilateral antegrade access, sheath selection, and strategic contrast administration. --- TIMESTAMPS 00:00 - Introduction 02:25 - Multidisciplinary and Global Collaboration 05:59 - Explaining the Woundosome Concept 07:51 - Understanding Wound Perfusion 10:20 - Assessing the Effectiveness of Revascularization 20:09 - Case Example with Pictures 28:07 - Technical Tips for CLI Interventions --- RESOURCES Find Your Algorithm (FYA): https://fya-congress.com/ The "Woundosome" Concept and Its Impact on Procedural Outcomes in Patients With Chronic Limb-Threatening Ischemia: https://journals.sagepub.com/doi/10.1177/15266028241231745?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed Vascular imaging of the foot: the first step toward endovascular recanalization (Manzi): https://pubmed.ncbi.nlm.nih.gov/21997985/ BASIL-2 Trial: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)00462-2/fulltext BackTable VI Ep. 90- Pedal Acceleration Time for Limb Salvage with Jill Sommerset and Dr. Mary Constantino: https://www.backtable.com/shows/vi/podcasts/90/pedal-acceleration-time-for-limb-salvage The First-in-Man "Si Se Puede" Study for the use of micro-oxygen sensors (Montero-Baker): https://pubmed.ncbi.nlm.nih.gov/26004327/ PEDRA Perfusion Monitoring: https://www.pedratech.com/ Armada XT Balloon: https://www.cardiovascular.abbott/us/en/hcp/products/peripheral-intervention/peripheral-dilatation-catheters/armada-14.html

(0:00) Bestie Intros: Jason's first show for his new production company (2:15) Why Sacks and Chamath are hosting a Trump fundraiser (18:40) House COVID investigation: findings, cover-up, what's next? (41:36) The Deep State Problem: unelected bureaucrats running three letter agencies for decades (53:04) Crypto Corner with Chamath (1:04:15) State of SaaS: Salesforce drops 20%, market teetering (1:20:10) Trump verdict: guilty on 34 counts of falsifying business records (1:37:36) Are we seeing an AI correction? Follow the besties: https://twitter.com/chamath https://twitter.com/Jason https://twitter.com/DavidSacks https://twitter.com/friedberg Follow on X: https://twitter.com/theallinpod Follow on Instagram: https://www.instagram.com/theallinpod Follow on TikTok: https://www.tiktok.com/@all_in_tok Follow on LinkedIn: https://www.linkedin.com/company/allinpod Intro Music Credit: https://rb.gy/tppkzl https://twitter.com/yung_spielburg Intro Video Credit: https://twitter.com/TheZachEffect Referenced in the show: https://oversight.house.gov/release/new-select-subcommittee-report-recommends-ecohealth-alliance-president-debarred-and-criminally-investigated-exposes-failures-in-nih-grant-procedures https://oversight.house.gov/release/hearing-wrap-up-nih-repeatedly-refutes-ecohealth-alliance-president-dr-peter-daszaks-testimony-tabak-testimony-reveals-federal-grant-procedures-in-need-of-serious-reform https://www.axios.com/2021/07/20/fauci-rand-paul-wuhan-institute https://oversight.house.gov/release/breaking-hhs-suspends-funding-and-proposes-formal-debarment-of-ecohealth-alliance-cites-evidence-from-covid-select-report https://oversight.house.gov/release/breaking-hhs-to-debar-dr-peter-daszak-president-of-ecohealth-alliance https://x.com/emilyakopp/status/1795482121739354552 https://x.com/R_H_Ebright/status/1795454118594568312 https://www.youtube.com/watch?v=jGxSlW0NrB4 https://www.cidrap.umn.edu/dual-use-research/feds-lift-gain-function-research-pause-offer-guidance https://www.washingtonpost.com/opinions/a-flu-virus-risk-worth-taking/2011/12/30/gIQAM9sNRP_story.html https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3484390 https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30418-9/fulltext https://oversight.house.gov/release/new-covid-select-memo-details-allegations-of-wrongdoing-and-illegal-activity-by-dr-faucis-senior-scientific-advisor https://fiscaldata.treasury.gov/americas-finance-guide/national-deficit https://x.com/KatherineEban https://x.com/emilyakopp https://www.semafor.com/article/05/28/2024/a-dying-empire-led-by-bad-people-poll-finds-young-voters-despairing-over-us-politics https://www.youtube.com/watch?v=nvQTXAgtA6s https://s23.q4cdn.com/574569502/files/doc_financials/2025/q1/CRM-Q1-FY25-Earnings-Press-Release-w-financials.pdf https://www.investors.com/news/economy/federal-reserve-core-pce-inflation-gdp-q1-jobless-claims-sp-500 https://www.nytimes.com/live/2024/05/30/nyregion/trump-trial-verdict https://www.google.com/finance/quote/DELL:NYSE https://www.bloomberg.com/news/articles/2024-05-30/us-gdp-grew-at-softer-pace-as-spending-inflation-marked-down

In "Lungs & Udders," Dr. Osterholm provides updates on H5N1 influenza, COVID-19, and mpox. He also shares his thoughts on a recent WHO report about airborne transmission and a study on the use of a diabetes drug to treat COVID-19. Airborne pathogens: controlling words won't control transmission (Greenhalgh et al., The Lancet) Sign up for CIDRAP's daily newsletter MORE EPISODES       SUPPORT THIS PODCAST

In this 211th in a series of live discussions with Bret Weinstein and Heather Heying (both PhDs in Biology), we talk about the state of the world through an evolutionary lens.In this episode, we discuss Winter and seasonality, before a longer discussion of overfitting, shoe-horning, and straight-jacketing. How do models, collusion, and Occam's Razor contribute to how we understand the world? Why are generalists better situated to interpret complexity than are specialists? Then: how good is the science behind the major paper out of The Lancet that assures us that we should not be eating red meat? Answer: not very. Finally, we discuss the orcas who were trapped in sea ice off of Japan, and what it means to be an orca (including mention of the grandmother hypothesis).*****Our sponsors:MDHearing: To get our $397 when you buy a PAIR offer, head to Shopmdhearing.com and use code DARKHORSE.  Helix: Excellent, sleep-enhancing, American-made mattresses. Go to www.HelixSleep.com/DarkHorse and use code HELIXPARTNER20 to get up to 20% of all mattress orders AND 2 free pillows.ARMRA: Colostrum is our first food, and can help restore your health and resilience as an adult. Go to www.tryarmra.com/DARKHORSE to get 15% off your first order.*****Join us on Locals! Get access to our Discord server, exclusive live streams, live chats for all streams, and early access to many podcasts: https://darkhorse.locals.com/Heather's newsletter, Natural Selections (subscribe to get free weekly essays in your inbox): https://naturalselections.substack.comOur book, A Hunter-Gatherer's Guide to the 21st Century, is available everywhere books are sold, including from Amazon: https://a.co/d/dunx3atCheck out our store! Epic tabby, digital book burning, saddle up the dire wolves, and more: https://darkhorsestore.org*****Mentioned in this episode:The Emperor of Scent by Chandler Burr (about Luca Turin): https://www.amazon.com/Emperor-Scent-Story-Perfume-Obsession/dp/0375759816 Willett et al 2019. Food in the Anthropocene: the EAT–Lancet Commission on healthy diets from sustainable food systems. Lancet 393, 447–492: https://www.thelancet.com/action/showPdf?pii=S0140-6736%2818%2931788-4Stanton 2024. Unacceptable use of substandard metrics in policy decisions which mandate large reductions in animal-source foods. Npj Science of Food 8(10): https://www.nature.com/articles/s41538-024-00249-yStanton et al 2022. 36-fold higher estimate of deaths attributable to red meat intake in GBD 2019: is this reliable?. The Lancet, 399(10332), pp.e23-e26.: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(22)00311-7/fulltextSupport the show