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This show has been flagged as Clean by the host. -------------------- 01 Introduction This is the second follow up to my 8 part series on nuclear power. In this episode I will attempt to answer a question posed by brian in ohio in a comment on HPR4583. In that comment he said: 02 -------------------- Loving this series. Maybe Whiskey Jack could give some cost comparisons between large and small reactors. He could also give us a realistic look at nuclear plant safety/accidents compared to conventional power production. Looking forward to the episode on FORTH generation reactors ;-) -------------------- 03 End of quote. The first question I answered in my previous follow up, which was HPR4628. In this episode I will attempt to answer the second question, which was about the safety of nuclear power compared to other sources of electrical power generation. One of the HPR janitors encouraged me to make this episode, so I think we can thank him for getting another HPR episode made. 04 Defining the Scope First, let's define the scope of the question. This will cover electrical power generation only. Within that scope I will consider only the following sources of energy. 05 Coal Oil Natural Gas Hydroelectric Nuclear Wind Solar I won't cover geothermal, wave, or tidal power as these are only used in very small amounts and so there simply isn't enough literature on them to base a discussion on . 06 Foreshadow Conclusion I should mention right away that I cannot provide absolute answers to this question in the form of a nice, neat ranking table based on numbers from peer reviewed scientific sources. The reasons for this will become apparent, but to put it briefly, the data on which to base such a ranking simply doesn't exist. I will however provide context within which people can think about the issue. Wherever possible, I will provide links to the references that I used in the show notes so you can read further on this yourself. -------------------- 07 Energy Catastrophism versus Energy Uniformitarianism First though I need to go off on a slight geological detour in order to explain an important analogy that I will use. 08 In the 19th century there was a great debate among geologists over what is known as catastrophism versus uniformitarianism. In seeking to explain the origins of the earth and of the landscape that we see around us, there were two points of view. 09 One was "catastrophism". This is the belief that the mountains, valleys, and plains that we see around us were formed as a result of great catastrophes which occurred relatively recently in earth's history. This explanation was necessary in order to fit geological features into an earth that was believed to be only a few thousands of years old. This view was heavily influenced by religious belief. In this view Noah's flood was the great catastrophe and the fossils of dinosaurs were the remains of animals who had not been saved on the ark and so had died in the flood. 10 The other point of view was uniformitarianism. This was the hypothesis that the landscape we see around us can be explained by the very slow accumulation of very small changes over very long periods of time. For this to be true however, the earth had to be far older than the few thousand years that a literal reading of the bible would suggest. The earth in fact had to be many, many, millions of years old. 11 Eventually, the uniformitarian view won out and people understood that while some catastrophes can take place, the shape of the landscape is overwhelmingly due to small changes over very long periods of time. 12 How is this Relevant to this Episode You Ask? How this is relevant is that I will use this analogy to explain how we need to think about energy and safety. Very small numbers of deaths and injuries multiplied over many occurrences can add up to big numbers, comparable in scale or possibly even larger than a single catastrophe or even several of them. 13 I don't know if anyone else has used this analogy before, I have just thought of this when writing the script for this podcast. None the less, I think it is a very useful way of helping to understand the issues. 14 As an example of this, think about the well known case of the safety of flying versus the safety of travelling in your car. Air crashes are catastrophes that make the headlines. Automobile crashes are seldom more than local news at best. You have probably heard many times the claim that if you making a trip somewhere, you are safer to fly than to drive yourself in your car. 15 Example - Hydro versus Solar I will now present an example of this. Hydro electric power has some notable large scale catastrophes associated with it. Roof top solar power does not have any notable catastrophes that I am aware of. However, which is safer? 16 Hydro Catastrophes Here are three examples of hydro electric catastrophes in just one country, Italy. The Vajont Dam which collapsed in1963 An estimated 1,917 to 2,500 people died. The Sella Zerbino dam which collapsed in 1935. More than 100 people died. The Gleno Dam which collapsed in 1923. An estimated 350 people died. https://damfailures.org/ https://pmc.ncbi.nlm.nih.gov/articles/PMC4997708/ 17 I haven't tried to compile a global list of the worst hydro electric dam collapses, as this sort of information is actually very difficult to find, even on web sites dedicated to dam failures. An additional problem is that information on whether a dam was used for electric power generation or not is often not available. 18 Dam failures where contradictory or insufficient information is available on whether there was an associated hydro power plant include the 1975 Banqian Dam failure, where death estimates range up to a quarter of a million. 19 Solar Panel Slow Accumulation Contrast this with roof top solar panels. Many small accidents can add up to big numbers as well. 20 Health and safety literature discussing solar panel safety mention things such as Falls from roofs. Electric shock. Arc flash (burns from electrical arcing). Normal electrical safety procedures which are based around locking out sources of energy do not work with solar panels which makes safety more difficult. Heat stress due to working exposed in the hot sun. Warning from US government on falls by solar panel installers. https://stacks.cdc.gov/view/cdc/228946 https://www.osha.gov/green-jobs/solar 21 Why We Cannot Compare the Two Hydro catastrophes are not well documented, but we can at least find records of some of the most notable ones. However, even those have very large variations in estimates of deaths. 22 Roof top solar deaths however are largely undocumented. The industry is largely unregulated. There is no central authority which accumulates many individual deaths or injuries. At best there are worker and public safety bodies who simply accumulate those statistics into general construction or household injuries. 23 Thus we have no reliable means of comparing the two energy sources on a comparable basis. We face the same problem with all other major electrical energy sources. So far as I am aware, there are no peer reviewed scientific studies which compare the relative safety of all of the major electrical energy sources we are considering here based on actual numbers. -------------------- 24 Safety Risks I will now try to list some the major hazards for each of energy sources we are considering. There is however limited data available. In many cases we just have reference to worker safety organizations as to what the hazards are. I will not attempt here to put numbers to these here. Categories 25 Coal, Oil, Natural Gas The hazards are Air pollution Mining and oil field accidents Pipeline explosions Transportation accidents. These- move a lot of material so these are significant. 26 Hydroelectric These include Dam collapse Drowning 27 Nuclear These include Radiation exposure 28 Wind These include Falls Confined space deaths (there is not much detail on this) Electric shock Ice throws (that is, throwing pieces of ice off the blades) This technology has a significant problem with people working alone which greatly increases risks associated with other dangers. 29 Solar These include Falls Electric shock Arc flash Heat stress 30 I have not tried to cover all possible risks associated with each category, just the ones which each industry considers to be the risks they concern themselves with. There does not exist any means by which risks of similar types are compared across different industries. 31 Reliability of Supply is Also Safety In a completely electrified net zero society, reliability of supply is a safety matter. People will die in very large numbers in cold climates if they do not have heat. If we have no fossil fuels, we need to also consider how reliably does a grid based on any of the options work. I have not seen anyone attempt to address this question and will not attempt to address it here. However, it must be addressed in any comprehensive attempt to rank safety. -------------------- 32 Studies or Articles on Estimates of Relative Safety Despite the difficulties of comparing the safety of different sources of energy, some people have attempted this anyway. Different estimates done at different times had different focuses, so unfortunately we do not have a nice set of studies that we can neatly use to cross check one another. I will however list the names and the authors and summarize the results. -------------------- 33 The Health Hazards of Not Going Nuclear By Dr. Petr Beckman Published in 1976 The author of this book tried to address the relative safety of different sources of energy in the mid 1970s. However, it is old at this point, so I won't bother digging through its pages to find his figures. 34 He mainly focused on comparing electric power generated with coal to nuclear. His conclusion was that if the goal was to prevent deaths or ill health in the process of generating electricity, then the logical conclusion was to replace coal fired power plants with nuclear. 35 The book was relatively well known at the time, as least as far as books on energy are concerned, so I thought it was still worth mentioning. I happen to have a copy of this book which I bought back in that time period It was the 8th printing of the book, so it would appear to have had relatively good sales. 36 The author did address the issue of what I have termed "catastrophism" in his comparison of different energy sources, although I don't know if he used this phrase. I don't know if he was the first to use this sort of analysis, but he certainly was very influential in terms of popularizing it. -------------------- 37 Risk of Energy Production by Herbert Inhaber Publication AECB 1119 March 1978 This study is a scientific paper from the same time period as the book "The Health Hazards of Not Going Nuclear". 38 He based his risk estimates largely on estimates of the amount of material which was used in the construction and operation of various power sources. While we could argue over whether or not this is a valid methodology, I think any such argument would be pointless as I think the age of the study alone renders it not relevant today anyway. Advancements in materials have changed the basis results significantly by now. However, as it exists I thought I would mention it to show that the idea of comparing energy sources to each other is not a new one. The author compared a wider variety of potential sources than Beckman did. 39 Here's his conclusions. He assumes equal amounts of energy produced by each method. The numbers are normalized such that the total sums to 100%. You can think of it in terms of what proportion of total deaths or injuries would result from each source if each were equally used. 40 Coal 27.5% Oil 25.6% Methanol 16.7% Wind 10.8% Solar photovoltaic 9.2% Thermal 8.1% Solar space heating 1.5% Ocean thermal 0.4% Nuclear 0.13% Natural Gas 0.08% 41 His natural gas estimate is drastically different from that of other authors. I am not going to worry about explaining it however, as the study is as I said old enough to be not very relevant anyway. I am mainly including this here out of historical interest. 42 As a footnote, the methanol he refers to would be synthesized from wood. This was a popular idea in that era as a means of providing liquid fuels for transportation. Practical battery electric cars in those days were strictly science fiction. 43 The ocean thermal category is a real blast from the past and I had forgotten all about that concept. It was a very popular idea at that time and was supposed to be *the* big and upcoming thing in renewable energy. It involved various means of attempting to extract energy from differences in water temperature at different depths in the ocean. It gradually faded away however, as despite great efforts being put into it, designs never proved to be practical. -------------------- 44 Electricity generation and health Anil Markandya, Paul Wilkinson Published in the Lancet, Vol 370, 15 September 2007 45 This is more recent than the previous one, although it is nearly 20 years old at this point. Unfortunately it doesn't cover wind or solar, just fossil fuels and nuclear. However it is still useful, and the Lancet is a very reputable peer reviewed journal. 46 I will present just the results rather than discussing the whole paper. The authors break it down into deaths among the public, occupational deaths, and air pollution related deaths, serious illness, and minor illness. 47 They break the energy sources down into lignite, coal, gas, oil, biomass, and nuclear. Lignite is a type of very low grade coal used mainly for electric power generation. In this paper biomass refers to energy crops and forest residues. 48 I will summarize the results by category rather than trying to describe a table that has 6 rows and 5 columns. All numbers are normalized in terms of deaths or cases per TWh. 49 Occupational deaths from accidents lignite 0.1 coal 0.1 gas 0.001 oil no data biomass - no data Nuclear is 0.019. 50 Deaths among the public from accidents lignite 0.02 coal 0.02 gas 0.02 oil 0.03 biomass no data Nuclear 0.003 51 Air pollution deaths lignite 32.6 coal 24.5 gas 2.8 oil 18.4 biomass 4.63 Nuclear 0.052 52 Air pollution serious illnesses lignite 298 coal 225 gas 30 oil 161 biomass 43 Nuclear 0.22 53 Air pollution minor illnesses lignite 17,676 coal 13,288 gas 703 oil 9,551 biomass 2,276 Nuclear no data 54 Natural gas edges out nuclear power slightly in terms of occupational safety, but in every other category nuclear is drastically lower in terms of ill effects than any of the alternatives. -------------------- 55 2020 Fatalities for US Roofers Increased 15% as Solar Roof Installations Increase Published in The Next Big Future July 6, 2021 by Brian Wang 56 This seems to be written by someone who has a popular science blog. I'm not familiar with it personally, but he addresses the subject so I'll list it. The title implies that it's all about rooftop solar, but he provides comparative numbers for the other energy sources of interest, so that is useful for our purposes. However, he doesn't describe his methodology, so we need to treat them with some caution. Here are his results These are deaths per thousand terawatt hours. 57 Coal - 100,000 Oil - 36,000 Natural gas - 4,000 Hydro - 1,400 Rooftop solar - 440 Wind - 150 Nuclear - 90 58 If we plot these numbers on a bar chart, coal and oil are so large that all of the others are squished to the bottom of the chart and are difficult to see at all. Let's therefore look at these in terms of orders of magnitude. Keep in mind that this is a logarithmic scale. This means that the difference between 4 and 5 is much greater in linear terms than the difference between 1 and 2. 59 Coal - 5 Oil - 4 Natural gas - 3 Hydro - 3 Rooftop solar - 2 Wind - 2 Nuclear - 1 60 Each of these numbers represents an order of magnitude, that is a power of ten. We can see that with rooftop solar, wind, and nuclear, the numbers are so close and the uncertainties are so great and their relative values so small compared to say coal that they can be seen as equivalent so far as safety is concerned. -------------------- 61 What are the safest and cleanest sources of energy? by Hannah Ritchie Published in Our World in Data First published in 2017, updated in 2022 and 2024 62 The author of this study addressed both deaths and greenhouse gas emissions. Deaths from accidents and air pollution are normalized to per TWh of electricity, while greenhouse gas emissions are normalized to GWh of electricity over the life cycle of the plant. 63 Here are the death figures. Coal 24.6 Oil 18.4 Biomass 4.6 Natural Gas 2.8 Hydro power 1.3 Wind 0.04 Nuclear 0.03 Solar 0.02 64 For greenhouse gas emissions the figures are Coal 970 tons Oil 720 tons Natural gas 440 tons Biomass 78 to 230 tons Solar 53 tons Hydro power 24 tons Wind 11 tons Nuclear 6 tons 65 If we take the death figures and rank them by order of magnitude as we did with the previous article, we get the following. 66 Coal - 4 Oil - 4 Biomass - 3 Natural Gas - 3 Hydro power - 3 Wind - 1 Nuclear - 1 Solar - 1 67 Keep in mind that the previous article covered only rooftop solar and not large industrial installations, and so is not directly comparable. Also the units are different, with the previous article being in terms of thousand TWh, and this one being in TWh. If we exclude solar (as the numbers are not comparable), Brian Wang's numbers are between 1.5 to 4 times higher than Ritchie's, except for hydro which are almost identical. I think this latter is due to both sets of numbers are dominated by one exceptionally big hydro accident. 68 Overall however, the relative rankings are quite comparable. Ritchie's numbers for deaths from coal, oil, and natural gas appear to be directly from the study by Markandya and Wilkinson mentioned above. For the benefit of those who are wondering, Ritchie specifically states that her numbers for nuclear include the Chernobyl and Fukushima accidents. -------------------- https://www.iaea.org/publications/magazines/bulletin/21-1/solar-power-more-dangerous-nuclear Direct link to file https://www.iaea.org/sites/default/files/publications/magazines/bulletin/bull21-1/21104091117.pdf https://ourworldindata.org/safest-sources-of-energy https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(07)61253-7/abstract https://www.nextbigfuture.com/2021/07/2020-fatalities-for-us-roofers-increased-15-as-solar-roof-installations-increase.html -------------------- 69 Conclusion from Studies Remember that in engineering terms, when comparing groups of numbers which contain both both very small numbers and one or more very large numbers, the differences between the small numbers are often not significant. The differences between the small numbers may be the product of our ability to measure these things rather than any real differences. 70 For example, in the article by Ritchie wind power would appear to be twice as dangerous as nuclear. However, the difference between them is 0.02 compared to 24.6 for coal. In other words, the difference between apparently "dangerous" wind and apparently "safe" nuclear is equivalent to 0.08% of the total for coal. It's therefore meaningless and a red herring to even worry about. 71 With the above taken into consideration, generally the different sources of energy fall into two broad categories in terms of number of deaths, injuries, and illnesses. The fossil fuels and biomass fall into one group and wind, solar, and nuclear into another group. 72 Hydro power would seem to fall into the higher risk category or at least somewhere between the two, but this I suspect is mainly due to one exceptionally large dam collapse in China, the Banqian Dam failure in 1975. This is mentioned as being specifically included in the article written by Ritchie. This was a multi-purpose dam, and information on this dam is difficult to find. It is not clear to me whether it had a hydro electric generator associated with either it or another dam that was part of the same system. 73 Some people therefor may argue for its exclusion from the numbers. Of course some people may argue for its inclusion anyway, as it was a dam regardless of whether it actually had an electric generator attached. If we exclude it, then I think the numbers for hydro power would fall into the same range as for nuclear, wind, and solar. 74 Most people would consider hydro power to be safe and clean enough regardless of this and I will rank it as such in any conclusions that I come to. As you can see, even if we have numbers, it can be a matter of opinion as to how to interpret them. -------------------- -------------------- 75 Taking a Systems Approach Now let's take a look at the broader energy picture today and into the future. Many countries in many parts of the world have committed to the concept of "Net Zero", which means eliminating carbon emissions on a net basis. Net zero essentially means the complete electrification of society. We must therefore have electrical energy on demand and at low cost. We must as a result of this look at complete electrical systems rather than individual sources in isolation. 76 At one time many electrical systems were entirely coal or entirely hydroelectric. This is no longer the case. There are now major amounts of wind and solar involved in many countries. However these are inherently intermittent. This means that other sources of energy are inherently also required to have a functional system. 77 If any particular solution inherently requires fossil fuels to meet part of the demand, then the safety, pollution, and climate issues relating to those fossil fuels have to be factored in to that complete system when trying to come up with a relative ranking. Talking about Individual sources in isolation are therefore meaningless in these countries. 78 There are battery systems, but these are mainly used to stabilize and regulate the grid plus to a lesser degree to smooth out short term daily peaks in demand. They do not have the ability to store large amounts of electricity on a large scale for an entire grid for days, weeks, and months to make up for intermittency. 79 So a serious attempt to rank sources of energy would need to look at a variety of representative countries and for each one come up with a plan that involves 'x' megawatts from source 'a', 'y' megawatts from source 'b', etc., and total up the values for each. 80 I am not aware of anyone who has studied this larger issue. However, the problem has to be addressed from this perspective in order for any answer to be useful. Not taking this into account is like ordering a diet soft drink to go with with a high calorie meal and assuring yourself that your plans to diet are fine. 81 This is not to imply there is anything inherently wrong with wind or solar. It does mean that if your goal is to achieve both net zero and a clean environment, you have to look at your entire energy system as a complete system rather than focusing on what you feel are the most reassuring parts of it while ignoring the rest. This does however add to the argument that it is in fact inherently very difficult to come up with a system of ranking energy sources for safety. -------------------- 82 Nuclear, Climate, and Clean Air - Contrasting Examples To give a tangible example we will now look at two different places that followed two divergent paths at roughly around the same time frame. These are the province of Ontario in Canada, and Germany. 83 Ontario had a mix of coal, hydro electric, and nuclear generating plants. Germany had a mix of coal, nuclear and natural gas plants. Ontario shut down their coal fired plants and kept their nuclear plants. Germany however shut down their nuclear plants and kept their coal fired plants. 84 The Phase Out of Coal in Ontario In 2003 Ontario decided to close all of its coal fired generating plants, which consisted of 19 units (that is boilers and turbines) totalling 8,800 MW. This phase out was completed by 2014. 85 Here are the figures for amount of power generated by each energy source in 2003 and 2014. Nuclear went from 42% to 60% Hydro went from 23% to 24% Gas went from 11% to 9% Coal went from 25% to 0% Non-hydro renewable went from 0% to 7%. 86 As you can see, the bulk of that replacement came from increased use of nuclear power. Furthermore, this did not result in simply replacing coal with natural gas. While gas is cleaner than coal, it still has emissions and if you recall from the studies that we looked at earlier, had an estimated death rate roughly 2 orders of magnitude greater than nuclear, solar, or wind. 87 To put this in more practical terms, at one time Toronto regularly had clouds of smog obscuring it, to a large extent due to these coal fired power plants With the phase out of coal, smog days went to zero in 2015 compared to 53 a decade earlier. The 2023 figures for Ontario show carbon emissions of 53 grams per kWh of electricity generated. We can use this as a rough benchmark comparison for total emissions. 88 The Phase out of Nuclear in Germany Until March of 2011, Germany generated one quarter of its electrical power from nuclear. Starting in 2011 however, they began shutting down their nuclear power plants. These were then phased out over the next decade. However, the coal plants were to be kept to 2038. In 2026 Germany began talking about increasing use of coal in order to save gas. In the same year the German chancellor Friedrich Merz stated that the phase out of nuclear was a quote “serious strategic mistake”. EU Commission President Ursula von der Leyen said it was "a strategic mistake for Europe to turn its back on a reliable, affordable source of low-emissions power". 89 I won't go into the details of the phase out, but let's look at some emissions numbers for Germany. If we look at the official numbers from the European Environmental Agency for 2024, for Germany their emissions were 298 grams per kWh of electricity generated. Recall that we are using emissions as a very rough guide to amount of air pollution, and that this has a direct effect on the safety of the overall electrical energy system. 90 So, who actually made their people safer, Ontario who phased out their coal plants and kept their nuclear plants, or Germany who phased out their nuclear plants and kept their coal plants? 91 If you want a comparison directly within Europe, then Germany has one of the highest rates of emissions per kWh of electricity generated, whereas France, who use mainly nuclear power, have one of the lowest at 43 grams per kWh of electricity generated. Again, who is making their people safer, Germany or France? 92 I don't want to make it sound like I am picking on Germany. I am also not going to tell them how they ought to run their country. However they provide a good real world example of how we need to look at things in overall context when we are thinking about the choices that we make. https://www.ontario.ca/page/end-coal https://www.cbc.ca/news/canada/windsor/smog-study-shows-significant-decreases-in-pollutants-in-ontario-1.4151183 https://www.eea.europa.eu/en/analysis/indicators/greenhouse-gas-emission-intensity-of-1 https://world-nuclear.org/information-library/country-profiles/countries-g-n/germany https://www.politico.eu/article/friedrich-merz-is-right-to-reject-germanys-nuclear-phase-out-says-iea-chief-fatih-birol/ https://www.politico.eu/article/germany-considers-ramping-up-coal-power-to-avert-energy-crisis/ https://www.iea.org/countries/estonia/electricity https://www.iea.org/countries/malta/electricity -------------------- 93 Conclusions As we can see, there don't appear to be an abundance of peer reviewed scientific studies that we can simply point to in order to answer the question of safety of all possible major different energy sources once and for all. Collecting the data to even attempt to answer the question is inherently very difficult as we cannot readily conduct experiments to answer the question, and sources of data are not collected or consolidated in a manner which can answer this question adequately. 94 The essence of the problem is that most energy industries are not as tightly regulated and monitored to the same degree that say nuclear power or commercial airliners are, so this data is simply not being systematically recorded. However, a number of people have attempted to make estimates. 95 Their conclusions would seem to be that nuclear, wind, and solar are roughly equivalent in terms of safety. All fossil fuels are much less safe than nuclear, wind, and solar, by as much as several orders of magnitude. 96 We can however say with a reasonable degree of certainty that if a country shut down their nuclear power plants and kept their fossil fuel plants, particularly coal, then they probably made their people less safe than if they had done things the other way around. 97 I hope that I have provided some context in which to think about the issue. Thanks again to brian in ohio for providing the question upon which this episode is based. -------------------- Provide feedback on this episode.

Free course: Improve your metabolic healthGet our free email course on how glucose, nutrition, exercise, sleep, and measurement can help you build habits that support better energy and long-term health: ⁠⁠⁠https://levels.link/wnl⁠High cholesterol. Elevated ApoB. A positive CAC score. Now what?Most people quickly find themselves trapped between two extremes: simplistic advice to “cut saturated fat” and online influencers insisting cholesterol doesn't matter at all.In this episode of A Whole New Level, Mike Haney sits down with clinical research scientist Dr. Kevin Maki to cut through the confusion.Drawing on more than 35 years of cardiovascular research, Maki explains why heart disease risk is about much more than LDL cholesterol alone. He breaks down the roles of inflammation, blood sugar, family history, kidney function, and lipoproteins, while also making a clear case for something many people resist: LDL and ApoB still matter. A lot.The evidence increasingly suggests that when it comes to atherosclerosis, lower for longer is better. That has important implications for diet, statins, and how early we should intervene.Mike and Dr. Maki also tackle saturated fat, seed oils, red meat, industry-funded research, and how to separate evidence from online nutrition debates.

Einiges los! Johannes und Roman werfen wieder ein paar Schlaglichter auf aktuelle Entwicklungen. Es gibt Updates von den Hanta- und Ebola-Virus-Ausbrüchen, Ungereimtheiten bei archivierten Mäusen und erste Tests zum „De-Aging“ bei Menschen (erstmal nur im Auge, um Grünen Star, auch bekannt als Glaukom, zu behandeln). Außerdem philosophieren Roman und Johannes zum Beitrag von Viren in der menschlichen Evolution. Und: Eine neue Genschere verspricht noch präziser im menschlichen Genom herumzuschnippeln und eine neue Studie an menschlichen Embryonen hat die Diskussion über die ethischen Grenzen der Gentechnik wieder neu angefacht. Unsere Hosts gegeben Einblicke, die man nicht überall bekommt, und fassen zusammen, was sie rausbekommen haben. Quellen und weitere Infos sind wie immer unten verlinkt. Um auch die nächste Folge nicht zu verpassen, jetzt abonnieren und weitersagen – überall, wo es Podcasts gibt! Links & Quellen zur Folge: Hanta-VirusLancet-Studie: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(26)01124-4/fulltextÜbersicht über Impfstoffe und Therapien beim Andes-Virus (u.a. von Floria Krammer): https://www.nature.com/articles/s44298-026-00200-w Ebola / Bundibugyo-VirusBei der WHO: https://www.who.int/emergencies/alert-and-responseScience Interview mit WHO-Offiziellem: https://www.science.org/content/article/working-without-them-painful-who-s-ebola-chief-reflects-u-s-colleagues-absence   Charité – US-Patient und Familie entlassen: https://www.charite.de/service/pressemitteilung/artikel/detail/patient_aus_sonderisolierstation_der_charite_entlassen Podcast-EmpfehlungPandemia-Podcast mit Kai Kupferschmidt und Laura Salm-Reifferscheidt: https://superelektrik.de/pandemia/ HERVs & Friends with BenefitsÜbersichtsartikel (2014) von Roman & Co: https://pmc.ncbi.nlm.nih.gov/articles/PMC4212686/HERVs: https://www.laborjournal.de/rubric/hintergrund/hg/hg_22_12_02.php Qualitätssicherung bei Mausstämmen und deren ArchivierungPolicy Proposal vom MMRRC in Science: https://www.science.org/doi/10.1126/science.aec3177 Reaktion von Infrafrontier: https://www.infrafrontier.eu/news/response-to-growing-discussion-on-genetic-quality-control/ MMRRC: https://www.mmrrc.org/EMMA: https://www.infrafrontier.eu/emma/ Longevity & De-AgingLandmark-Study zur viralen OSK-Delivery: https://www.nature.com/articles/s41586-020-2975-4Klinische Studie zum Glaukom / Grüner Star: https://clinicaltrials.gov/study/NCT07290244 Folgen S4E16 & S4E17: „Alter – was geht?“ mit Prof. Christoph Englert vom Leibniz-Institut für Alternsforschung: https://www.tierversuche-verstehen.de/s4e16-alter-was-geht-teil-1/ Human EditingNeuer Ansatz zu genetischen Veränderungen an menschlichen Embryonen (Preprint-Veröffentlichung): https://www.biorxiv.org/content/10.64898/2026.05.30.728989v1    Einordnung in der New York Times: https://www.nytimes.com/2026/06/04/science/embryos-gene-editing-crispr.html (€) Übersichtsportal mit wissenschaftlichen und ethischen Einschätzungen zum Human Gene Editing (dt.: „Genomchirurgie“): https://www.leopoldina.org/themen/genomchirurgie Fragen, Anregungen, Wünsche und Feedback gerne an die Email-Adresse: 3F@tierversuche-verstehen.de oder via Bluesky @TVVde, @ProfBeckers.bsky.social, @neuromancing.bsky.social oder Mastodon @TVV, @NeurRoman_cer@fediscience.org oder via X @TVVde, @JohBeckershttps://www.tierversuche-verstehen.de

Slovenski nefrolog sodeloval pri objavi treh člankov o kronični ledvični bolezni v znanstveni reviji Lancet.Ledvice lahko izgubljajo svojo funkcijo več let, ne da bi to opazili. Razvije se kronična ledvična bolezen (KLB), ki je po ocenah strokovnjakov ena najhitreje naraščajočih zdravstvenih težav sodobnega časa. Žal je pogosto spregledana, čeprav jo odkrije že enostavna analiza krvi in urina. O tem, kdo je najbolj ogrožen, kako poteka zgodnje odkrivanje bolezni in kakšne so možnosti zdravljenja, v Ultrazvoku govori nefrolog doc. dr. Andrej Škoberne (UKC Ljubljana). Dr. Škoberne je kot član mednarodne skupine strokovnjakinj in strokovnjakov v ugledni znanstveni reviji Lancet sodeloval pri objavi treh člankov, s katerimi splošno in strokovno javnost opozarjajo na pomen pravočasnega odkrivanja kronične ledvične bolezni. Na podlagi podatkov namreč ocenjujejo, da v razvitih državah kar od 30 do 50 odstotkov bolnikov s KLB še nima prepoznane bolezni. Originalni članki v znanstveni reviji Lancet: Članek 1 TUKAJ Članek 2 TUKAJ Članek 3 (drugopodpisan dr. Škoberne) TUKAJ Oddaja Ultrazvok - Nefrolog: Umetna inteligenca dokazala, da se ledvični bolniki pospešeno starajo TUKAJ  Foto: Andrej Škoberne/ UKC Ljubljana

Can you really treat prostate cancer effectively without knowing the genetics? In this episode of BackTable Urology, Dr. Evan Yu and Dr. Tanya Dorff join host Dr. Alan Tan to discuss why genetic testing is essential in personalized prostate cancer care. They discuss when and how to perform germline and somatic testing, address common barriers, and share best practices for counseling patients. --- Get the BackTable apphttps://www.backtable.com/app --- This podcast is supported by an educational grant from Pfizer. --- Timestamps 00:00 - Introduction02:18 - Who Gets Somatic Testing?06:43 - Patient Barriers to Testing09:00 - Genetic Testing Workflow12:28 - Treating BRCA2 Alterations24:18 - Monitoring Progression: ctDNA vs. PSA vs. Imaging29:32 - Treating mCRPC with ATM Mutations34:39 - CDK12 Classification 37:43 - Closing Takeaways --- More about this episode The doctors explore how BRCA2 and other DNA repair alterations can directly shape treatment decisions, focusing on the roles of PARP inhibitors and platinum therapy in advanced cases. The discussion highlights why both germline and somatic testing are critical for identifying actionable mutations and discuss the nuances of interpreting test results, including current limitations and emerging biomarkers. They also examine challenges such as insurance coverage, patient misconceptions, and workflow integration, as well as the movement toward truly personalized, biology-driven approaches in prostate cancer care. --- Resources Niraparib and abiraterone acetate plus prednisone for HRR-deficient metastatic castration-sensitive prostate cancer: a randomized phase 3 trial:https://pmc.ncbi.nlm.nih.gov/articles/PMC12705445/ Capivasertib plus abiraterone in PTEN-deficient metastatic hormone-sensitive prostate cancer: CAPItello-281 phase III study:https://www.annalsofoncology.org/article/S0923-7534(25)04936-1/fulltext Apalutamide for Metastatic, Castration-Sensitive Prostate Cancer:https://www.nejm.org/doi/full/10.1056/NEJMoa1903307 ARCHES 5-year Survival with Enzalutamide Plus Androgen-deprivation Therapy in Metastatic Hormone-sensitive Prostate Cancer Patientshttps://www.sciencedirect.com/science/article/pii/S0302283825048766 First-Line Camizestrant for Emerging ESR1-Mutated Advanced Breast Cancer:https://www.nejm.org/doi/abs/10.1056/NEJMoa2502929 PROMISE Registry:https://www.prostatecancerpromise.org/ Talazoparib plus enzalutamide in men with HRR-deficient metastatic castration-resistant prostate cancer: final overall survival results from the randomised, placebo-controlled, phase 3 TALAPRO-2 trial:https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)00683-X/abstract --- BackTable Urology is the go-to podcast for urologists, urologic oncologists, and urogynecologists. Download the free BackTable app to get early access to new episodes, cases, and courses curated by physicians in your specialty. ► https://www.backtable.com/app

From rubber bands and metal clips to fabric-covered elastics and slick buns, this episode explores how everyday accessories affects hair. We breakdown the mechanical and biological cost of tight, rough, or poorly chosen accessories, including breakage and hair loss.Tune in to learn how to choose better, style smarter, and protect your hair goals without losing your personality.Listen now and rethink your hair accessories.Download your free copy of the UTK-Podcast Hair Accessory Guide for hair accessory tips to support your hair goals.ReferencesBolduc, C., & Shapiro, J. (2001). "Management of hair loss." The Lancet, Vol. 357, Issue 9253, pp. 321-322. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(00)03630-1/fulltextDraelos, Z. D. (2010). "Essentials of Hair Care often neglected: Hair Cleansing." Journal of Cosmetic Dermatology, Vol. 9, Issue 4, pp. 312-315. https://onlinelibrary.wiley.com/journal/14732165Khumalo, N. P., et al. (2007). "Traction alopecia is caused by hair care practices." Journal of the American Academy of Dermatology, Vol. 57, Issue 2, pp. 221-230. https://www.jaad.org/article/S0190-9622(07)00583-1/fulltextMiteva, M., & Tosti, A. (2013). "Traction Alopecia." Dermatologic Clinics, Vol. 31, Issue 1, pp. 107-117. https://www.derm.theclinics.com/article/S0733-8635(12)00101-3/fulltextSwift, J. A. (1991). "The mechanics of fracture of human hair." Journal of the Society of Cosmetic Chemists, Vol. 42, pp. 1-18. https://library.scconline.org/v042n01/Send us Fan MailSend your questions about Afro-textured/coily hair to utkinhair@gmail.com.Check out your natural beauty hub, ÈYÍ DÁRA Naturals for natural hair care solutions.Follow us on instagram @utkpodcast

Bob Harringson and former FDA commissioner Rob Califf discuss medical misinformation, its impact on public and individual health, and how to fight against it. This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington  Is a Long-Simmering Crisis Boiling Over? U.S. Primary Care Today https://doi.org/10.1056/NEJMms2510425 The Global Wellness Economy Hits a Record $6.8 Trillion and Is Forecast to Reach $9.8 Trillion by 2029 https://globalwellnessinstitute.org/press-room/press-releases/the-global-wellness-economy-hits-a-record-6-8-trillion-and-is-forecast-to-reach-9-8-trillion-by-2029/  Life's Essential 8: Updating and Enhancing the American Heart Association's Construct of Cardiovascular Health: A Presidential Advisory From the American Heart Association https://doi.org/10.1161/CIR.0000000000001078  Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(04)17018-9/abstract  Here's What We Know https://weillcornell.org/heres-what-we-know  Fifth Circuit sides with ivermectin-prescribing doctors in their quarrel with the FDA https://www.courthousenews.com/fifth-circuit-sides-with-ivermectin-prescribing-doctors-in-their-quarrel-with-the-fda/  SNAP Tracker: People Are Losing Food Assistance as the Republican Megabill Is Implemented https://www.cbpp.org/research/food-assistance/snap-tracker-people-are-losing-food-assistance-as-the-republican-megabill  Chronic Conditions and Food Insecurity in US Children https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2839376  As Unregulated Peptides Flood the Market, Clinicians Encouraged to Counsel Patients https://www.medscape.com/viewarticle/unregulated-peptides-flood-market-clinicians-encouraged-2026a1000e63 Coethia https://coethia.com/  You may also like: Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology https://www.medscape.com/twic  Questions or feedback, please contact news@medscape.net

Keeping patients on PARP inhibitors long enough to see real benefit often comes down to proactive side effect management. In this episode of BackTable Urology, Dr. Neeraj Agarwal and Dr. Arun Azad join host Dr. Alan Tan to discuss practical, evidence-based strategies for managing hematologic and GI toxicities in advanced prostate cancer patients receiving PARP inhibitors. --- Get the BackTable apphttps://www.backtable.com/app --- This podcast is supported by an educational grant from Pfizer. --- Timestamps 00:00 - Introduction06:17 - Managing Anemia11:12 - Side Effect Profiles19:33 - Transfusions vs ESAs26:43 - Docetaxel vs PARP Inhibitors30:27 - Side Effect Management Pearls40:18 - Team Based Monitoring52:27 - Tissue Versus Liquid01:01:24 - Genetic Counseling Workflow01:07:07 - Trial Equity and Access --- More about this episode The doctors discuss the importance of close anemia monitoring during the critical first 3 to 4 months of therapy, maintaining dose intensity, proactive antiemetic use, and the role of exercise and resistance training in combating fatigue. The conversation also covers differences in toxicity profiles between PARP agents, the value of multidisciplinary care teams, molecular advances in molecular and germline testing, and the evolving landscape of emerging therapies in prostate care. --- Resources Talazoparib plus enzalutamide in men with metastatic castration-resistant prostate cancer: final overall survival results from the randomised, placebo-controlled, phase 3 TALAPRO-2 trialhttps://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)00684-1/abstract BRCAAway: A randomized phase 2 trial of abiraterone, olaparib, or abiraterone + olaparib in patients with metastatic castration-resistant prostate cancer (mCRPC) bearing homologous recombination-repair mutations (HRRm).https://ascopubs.org/doi/10.1200/JCO.2024.42.4_suppl.19 --- BackTable Urology is the go-to podcast for urologists, urologic oncologists, and urogynecologists. Download the free BackTable app to get early access to new episodes, cases, and courses curated by physicians in your specialty. ► https://www.backtable.com/app

Witam Państwa, nazywam się Jarosław Drożdż, pracuję w Centralnym Szpitalu Klinicznym Uniwersytetu Medycznego w Łodzi, skąd nagrywam podcast Kardio Know-How. W tym odcinku omawiam drugą część badań opublikowanych podczas kongresu ACC 2026. Tegoroczny kongres ACC w Nowym Orleanie przyniósł niezwykle interesujące doniesienia dotyczące przewlekłych zespołów wieńcowych, a szczególną uwagę zwróciły dwa duże badania z Korei Południowej dotyczące leczenia pacjentów ponad rok po zawale serca. Pierwsze z nich, SMART DECISION, opublikowane równolegle w NEJM: https://www.nejm.org/doi/full/10.1056/NEJMoa2601005, sugeruje, że u wyselekcjonowanych pacjentów po zawale serca z zachowaną frakcją wyrzutową i bez niewydolności serca odstawienie β-adrenolityku może nie pogarszać rokowania. Wyniki te wzbudziły ogromne zainteresowanie, ale jednocześnie wiele wątpliwości, ponieważ badana populacja była wyjątkowo zdrowa, miała bardzo niską śmiertelność i znacząco różniła się od populacji europejskiej, zarówno pod względem BMI, genetyki, jak i profilu ryzyka. Dlatego mimo medialnego entuzjazmu nadal obawiam się, że bezrefleksyjne odstawianie β-adrenolityków w naszej populacji może przynieść więcej szkód niż korzyści i pozostaję zwolennikiem ich utrzymywania po zawale serca, podobnie jak mówiłem wcześniej w podcastach: https://open.spotify.com/episode/66lI4H45oK0PsFeXNN3hAx?si=04412e4ab3fe4e5a oraz https://open.spotify.com/episode/1H4KdTnpGGYLqBRdW81xRw?si=e0699442be3446b5. Drugim niezwykle ważnym tematem było badanie HOST-EXAM i jego 10-letnia obserwacja, opublikowana w Lancet: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(26)00422-8/fulltext, pokazująca przewagę monoterapii klopidogrelem nad klasycznym leczeniem ASA po zakończeniu DAPT. W badaniu wykazano prawie 40% redukcję ostrych zespołów wieńcowych, niemal 50% redukcję udarów mózgu oraz wyraźne zmniejszenie ciężkich krwawień przy stosowaniu klopidogrelu zamiast ASA. Wyniki te potwierdzają wcześniejsze obserwacje i coraz mocniej podważają tradycyjny pogląd, że po zakończeniu DAPT naturalnym wyborem musi być wyłącznie ASA. Mimo że coraz częściej spotykam pacjentów prowadzonych wyłącznie na klopidogrelu i sam zaczynam akceptować takie podejście, nadal widzę praktyczne problemy związane z nagłymi zabiegami chirurgicznymi, urazami czy samodzielnym dokładaniem ASA przez pacjentów, którzy od lat słyszeli, że „aspiryna po zawale musi być zawsze”. Dlatego w 2026 roku w przewlekłych zespołach wieńcowych nadal utrzymuję β-adrenolityki po zawale serca, ale jednocześnie coraz wyraźniej dryfuję w kierunku monoterapii klopidogrelem zamiast ASA, obserwując jak szybko zmienia się współczesna kardiologia. Szczegółowy TRANSKRYPT do odcinka.Podcast jest przeznaczony wyłącznie dla osób z profesjonalnym wykształceniem medycznym.

Oh, What's in a Name? Irving F. Stein and Michael L. Leventhal first described the syndrome, originally known as Stein-Leventhal syndrome, in 1935, in the AJOG. They published a case series of seven women displaying a triad of symptoms, including hirsutism, amenorrhea (absent menstruation), and bilaterally enlarged polycystic ovaries. We now know that PCOS affects 1 in 8 women globally (170 million women of reproductive age worldwide), and that there are 4 main manifestations of the condition- reflecting its diverse phenotype. Now, as of 05/12/25, a collaboration across 56 leading academic, clinical, and patient organizations, as well as iterative global surveys that garnered responses from over 14,300 people with PCOS and multidisciplinary health professionals have endorsed a NEW term (Lancet) for this: polyendocrine metabolic ovarian syndrome. This is actually STAGE 7 of an 8 stage process Yep, 1-6 are already done). But hold on…this is not taking over tomorrow! There is a THREE-YEAR implementation strategy that has already gotten started and culminating in 2028. Listen in for details.1. Teede HJ, Khomami MB, Morman R, et al. Polyendocrine metabolic ovarian syndrome, the new name for polycystic ovary syndrome: a multistep global consensus process. The Lancet. Published online May 12, 2026. Accessed May 12, 2026. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(26)00717-8/fulltext2. International Evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome; 20233. https://www.contemporaryobgyn.net/view/global-consensus-renames-pcos-to-polyendocrine-metabolic-ovarian-syndrome-pmos-?utm_campaign=42986360-COG%20-%20Breaking%20News&utm_medium=email&_hsenc=p2ANqtz--5Of8-OwjOeKLtknr8YdFbh9G8_c7iQqliHnMz2pYOpi2x4Pp8dRH6bSHjrQIqnth_fLPywQM2ByNp7via22VJ8yyLbg&_hsmi=418414457&utm_content=418414457&utm_source=hs_email4. Polyendocrine Metabolic Ovarian Syndrome: New name to improve diagnosis and care of condition affecting 170 million women worldwide. Monash University. News release. May 12, 2026. Accessed May 12, 2026. https://www.eurekalert.org/news-releases/1127647

The Lancet's Niall Boyce and Jonathan Pimm, and eBioMedicine's Kalypso Karastergiou discuss an exciting new potential treatment for alcohol use disorder: semaglutide. As new research is published in The Lancet, they go behind the headlines with lead author Professor Anders Fink-Jensen to ask what the study showed, and what its implications are for the future of addiction medicine. Click here to read the full article:  https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(26)00305-3/fulltext

Welcome to When It Goes Wrong, the podcast about disasters, accidents and when things fall apart. On this episode,  we will be discussing the crimes of Harold Shipman, a Hyde GP who over 30 years killed around 250 victims, mostly elderly women, by injecting them with diamorphine. We will cover his history, crimes and what this meant for the medical field.  Please subscribe and review for more! You can follow the podcast on instagram at @whenitgoeswrongpod or email me at whenitgoeswrongpod@gmail.com.You can buy me a coffee at: https://ko-fi.com/whenitgoeswrongpodSources:https://en.wikipedia.org/wiki/Harold_Shipmanhttps://en.wikipedia.org/wiki/The_Shipman_Inquiryhttps://www.thelancet.com/journals/lancet/article/PIIS0140-6736(04)17635-6/fulltexthttps://csi.pressbooks.pub/uncserkill/chapter/chapter-16-harold-shipman-dr-death/Harold Shipman - Prescription for Murder - Jean Ritchie, Brian WhittleCatching a Killer Doctor - cautionary tales podcastHarold Shipman: Dr Death - I could murder a podcast

Episode 81. Demens rammer hjernen og gir varige reduserte kognitive evner. Det er mange forskjellige sykdommer som kan gi demens. Vi ønsker alle å holde oss hjernefriske så lenge som mulig! Professor Geir Selbæk deler forskningsråd som kan redusere demens.  I studio intervjuer Lise Elveseter og Jeanette Koht.   Les mer her: https://www.med.uio.no/klinmed/personer/vit/geirselb/ https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)01296-0/abstract https://www.aldringoghelse.no/lancet-kommisjon-med-nye-funn-om-demens/   Redaksjonen: Karoline Haslum Kongsvik (lege i spesialisering), Anna Bjerkreim (lege i spesialisering), Lise Elveseter (nevrolog), Philip Kaiser (lege i spesialisering), Nils Hauff (lege i spesialisering) og Jeanette Koht (nevrolog, ph.d).  Jingle: Christoffer E. Hørbo og Are Brean Klipp og lyd: Lise Elveseter Logo: Tilde Rasmussen     Følg oss på Facebook og Instagram!     

Episode 81. Demens rammer hjernen og gir varige reduserte kognitive evner. Det er mange forskjellige sykdommer som kan gi demens. Vi ønsker alle å holde oss hjernefriske så lenge som mulig! Professor Geir Selbæk deler forskningsråd som kan redusere demens.  I studio intervjuer Lise Elveseter og Jeanette Koht.   Les mer her: https://www.med.uio.no/klinmed/personer/vit/geirselb/ https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)01296-0/abstract https://www.aldringoghelse.no/lancet-kommisjon-med-nye-funn-om-demens/   Redaksjonen: Karoline Haslum Kongsvik (lege i spesialisering), Anna Bjerkreim (lege i spesialisering), Lise Elveseter (nevrolog), Philip Kaiser (lege i spesialisering), Nils Hauff (lege i spesialisering) og Jeanette Koht (nevrolog, ph.d).  Jingle: Christoffer E. Hørbo og Are Brean Klipp og lyd: Lise Elveseter Logo: Tilde Rasmussen     Følg oss på Facebook og Instagram!     

Did you know researchers found a specific bacteria — the one found in gum disease — in up to 95% of Alzheimer's patients' brains? And that menopause makes your mouth significantly more vulnerable to exactly this bacteria?In this episode, Amy digs into one of the most overlooked connections in brain health: the link between your oral health, the menopause transition, and Alzheimer's disease. We're talking about brain protection — and it's more actionable than almost anything else you can do.What You'll LearnWhat menopause actually does to your mouth — and why estrogen loss puts your gums, saliva, and bone at risk The bacteria called P. gingivalis — how it travels from your gums to your brain, and why it was found in 90–95% of Alzheimer's patients' brain tissueThe accelerated rate of cognitive decline when active gum disease is presentSix practical, evidence-based steps you can start tonight to protect your oral health — and your brainAbout the SPRING Trial — a promising clinical trial for people with mild to moderate Alzheimer's, now actively recruitingResources MentionedFree RESTORED Protocol Guide: moxie-club.com (link in description)SPRING Trial (Clinical Trial for Mild-Moderate Alzheimer's): springclinicaltrial.comAlcohol-Free Mouth Rinse (TheraBreath): [link in show notes]Electric Toothbrush (Philips Sonicare): [link in show notes]Research ReferencedOral Health and Menopause: A Comprehensive Review on Current Knowledge and Associated Dental Management. PMC3793432.Welberry et al. (2025). Reflections on The Lancet's Commission on Dementia Prevention, Intervention, and Care. The Lancet. PIIS0140-6736(25)00149-7.BrightFocus Foundation Zoom In on Dementia & Alzheimer's, Episode 41. Dr. Michael Detke, Lighthouse Pharmaceuticals.RESOURCES:Book a FREE Discovery Call with AmyOrder Amy's book Thoughts Are Habits Too:  Master Your Triggers, Free Yourself From Diet Culture, and Rediscover Joyful Eating.Schedule your Breakthrough Roadmap session with AmyFollow Amy on Instagram @amylangcoaching Follow Amy on Facebook @amylangcoachingSubscribe to Amy's YouTube channel @happyandhealthywithamy

This podcast was created in sponsorship with Toyota. Find a vehicle that makes memorable moments happen, from the 2026 RAV4 and Sienna to the Highlander and Grand Highlander. Plan the trip, pack the trunk, gather your crew, and go places—together. Toyota: People are the destination.  “It should be possible to maintain stable cognitive function into your eighth and ninth decades. But we don't really internalize that. We expect decline, and because we expect decline, we're less likely to engage in those things.” Dr. Tommy Wood is a neuroscientist, Associate Professor at the University of Washington School of Medicine, and author of The Stimulated Mind. With degrees from Cambridge and Oxford, he has published more than 100 scientific papers and lectured worldwide on brain health, metabolism, and human performance. He also serves as a performance consultant to world-class athletes, including Olympians and Formula 1 drivers, and co-founded the British Society for Lifestyle Medicine. 00:00 - What we know about brain biomarkers 03:59 - Dementia risk is modifiable 06:29 - Why you should get your steps in 08:52 - The effect of exercise on the hippocampus 15:05 - Muscle is a brain organ 20:42 - Give your brain the fuel it needs 25:12 - Creatine & brain health 27:22 - The convenience crisis 29:54 - The importance of making mistakes 31:30 - How to stimulate your brain enough 33:31 - Social connection = medicine 35:45 - Tommy's dream study 38:12 - The optimization trap Referenced in the episode:  Buy Tommy's book here: https://a.co/d/0aUGHI9s  Find Tommy on his website: https://www.drtommywood.com/  The Pointer Study: https://jamanetwork.com/journals/jama/fullarticle/2837046 The Lancet Study: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)01296-0/abstract  London Cab Driver Study: https://www.pnas.org/doi/10.1073/pnas.070039597 We hope you enjoy this episode, and feel free to watch the full video on YouTube! Whether it's an article or podcast, we want to know what we can do to help here at mindbodygreen. Let us know at: podcast@mindbodygreen.com. Learn more about your ad choices. Visit megaphone.fm/adchoices

Borelioza to jedna z najszybciej rosnących chorób zakaźnych w Europie — w Polsce zapadalność wzrosła ponad 13-krotnie w ciągu dwóch dekad. W tym filmie opowiadam pełną historię: od małego miasteczka Lyme w Connecticut, gdzie dwie zdeterminowane matki odkryły epidemię, której lekarze nie potrafili wyjaśnić, po współczesne kontrowersje, które podzieliły świat medycyny na dwa obozy.⚠️ Borelioza to też pole minowe pseudomedycyny. W filmie rozbieramy na czynniki pierwsze popularne "alternatywne metody leczenia boreliozy": biorezonans (aparat MORA), ozonoterapię, komory hiperbaryczne, srebro koloidalne, protokół Buhnera, a także kontrowersyjne wytyczne ILADS i ich wielomiesięczną antybiotykoterapię. Źródła:1. https://www.researchgate.net/publication/372963520_Lyme_Disease_and_Post-treatment_Lyme_Disease_Syndrome_Current_and_Developing_Treatment_Options2. https://thepharmacologist.org/lyme-disease/3. https://pmc.ncbi.nlm.nih.gov/articles/PMC3117402/4. https://www.nature.com/articles/ncomms17015. https://www.tandfonline.com/doi/full/10.1080/08912963.2014.8976996. https://pmc.ncbi.nlm.nih.gov/articles/PMC12213884/7. https://www.mdpi.com/2076-2607/10/2/2128. https://www.sciencedirect.com/science/article/pii/S12864579163002969. https://www.mdpi.com/2076-2607/12/9/176610. https://pmc.ncbi.nlm.nih.gov/articles/PMC2785505/11. https://pubmed.ncbi.nlm.nih.gov/11897061/12. https://www.cell.com/cell/fulltext/S0092-8674(20)31449-513. https://www.researchgate.net/figure/a-Schematic-representation-of-the-acquisition-development-and-transmission-of_fig2_34376071314. https://pubmed.ncbi.nlm.nih.gov/9532263/15. https://www.lymedisease.org/tick-lyme-transmission-time/16. https://pubmed.ncbi.nlm.nih.gov/41316418/17. https://pmc.ncbi.nlm.nih.gov/articles/PMC12672175/18. https://pubmed.ncbi.nlm.nih.gov/12061448/19. https://www.mp.pl/pacjent/choroby-zakazne/choroby-odkleszczowe/co-warto-wiedziec/211967,czy-rumien-wedrujacy-zawsze-oznacza-borelioze20. https://ptbk.uken.krakow.pl/choroby-odkleszczowe/21. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(11)60103-7/abstract22. https://pmc.ncbi.nlm.nih.gov/articles/PMC10483257/23. https://www.gov.pl/web/psse-znin/borelioza--cicha-choroba-przenoszona-przez-kleszcze24. https://pmc.ncbi.nlm.nih.gov/articles/PMC4657537/25. https://www.escmid.org/esgbor/26. https://www.idsociety.org/ID-topics/infectious-disease/lyme-disease/27. https://podyplomie.pl/medical-tribune/26348,jak-leczyc-borelioze-konca-sporu-nie-widac28. https://en.wikipedia.org/wiki/International_Lyme_and_Associated_Diseases_Society29. https://pubmed.ncbi.nlm.nih.gov/1634816/30. https://academic.oup.com/ofid/article/12/3/ofaf017/795425231. https://atgmedic.pl/biorezonans/borelioza/32. https://www.thelancet.com/journals/lanepe/article/PIIS2666-7762(21)00119-8/fulltext33. https://www.gov.pl/web/rpp/podsumowanie-dzialan-rzecznika-praw-pacjenta-w-zakresie-leczenia-boreliozy-metoda-ilads-i-pierwsza-kara-pieniezna-nalozona-w-tej-sprawie34. https://pubmed.ncbi.nlm.nih.gov/34788080/35. https://journals.sagepub.com/doi/10.1177/15303667251363125borelioza leczenie naturalne, zioła na boreliozę, protokół Buhnera, czystek na boreliozę, przewlekła borelioza leczenie, borelioza objawy, biorezonans borelioza, ozonoterapia borelioza, komora hiperbaryczna borelioza, srebro koloidalne borelioza, ILADS Polska, borelioza leczenie domowe, rdestowiec japoński borelioza, koci pazur borelioza, lekarz ILADS Polska, borelioza antybiotyki nie pomagają, reakcja Herxheimera borelioza, borelioza forum leczenie, borelioza leczenie ziołami, naturalne leczenie boreliozy, borelioza rumień wędrujący, neuroborelioza objawy, borelioza diagnostyka, choroba z Lyme, kleszcz borelioza, borelioza a depresja, borelioza stawowa, zespół poboreliozowy, borelioza szczepionka, Borrelia burgdorferi

Wir schauen was passiert, wenn Kokain oder Ecstasy legal zu kaufen wären, zum Beispiel in einer Apotheke. Steigt dann die Zahl der Abhängigen? Oder kann eine Entkriminalisierung zu mehr Sicherheit und Verantwortung führen? Alle Hintergründe von uns findest Du hier: www.quarks.de. / Hast du selbst ein Szenario, das wir prüfen sollen, oder Feedback? Schreib uns gerne an malangenommen@ard.de. Eure Hosts heute sind: Julia Nestlen und Samira El Hattab Und das sind unsere wichtigsten Quellen: Suchtexperte Dr. Jakob Manthey: https://www.zis-hamburg.de/mitarbeiter/manthey/ Mensch, Milieu & Mittel - das Suchtdreieck: https://drogentest.info/suchtdreieck/ Das Suchtpotential verschiedener Drogen schaut sich z.b. diese Studie hier an: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(07)60464-4/abstract Hier gibt es mehr Details zu Überdosierungen: https://www.nature.com/articles/srep08126 Fentanyl breitet sich auch in Deutschland aus: https://www.bundesdrogenbeauftragter.de/presse/detail/jetzt-handeln-und-drogenkrise-verhindern/ Seit 2024 ist Kiffen in Deutschland legal. Aber der Konsum ist nicht stark angestiegen: https://www.fdr.uni-hamburg.de/record/17993 Ob der Konsum steigt, hängt davon ab, wie wir legalisieren: https://www.bundesgesundheitsministerium.de/fileadmin/Dateien/5_Publikationen/Drogen_und_Sucht/Abschlussbericht/ECaLe_Technical_Report.pdf Illegale Drogen sind nicht automatisch gefährlicher als legale Drogen: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(07)60464-4/abstract Eine große Übersichtsstudie zeigt, dass weniger HIV-Fälle und weniger Drogentote durch eine Entkriminalisierung möglich sind: https://bmjopen.bmj.com/content/10/9/e035148 Wie sich die Entkriminalisierung von Drogen in Portugal auf das Gesundheitssystem auswirkt: https://drugpolicy.org/wp-content/uploads/2023/08/dpa-drug-decriminalization-portugal-health-human-centered-approach_0.pdf Warum es in Portugal aber auch wieder Rückschläge gibt: https://pmc.ncbi.nlm.nih.gov/articles/PMC11900517/ Viele Studien sagen: Es ist nicht eindeutig, ob eine Legalisierung zu weniger Drogenkriminalität führt. Ein Beispiel aus den USA: https://pmc.ncbi.nlm.nih.gov/articles/PMC6837267/ Wie der Staat durch mehr Steuereinnahmen profitieren kann: https://pmc.ncbi.nlm.nih.gov/articles/PMC6837267/ Mehr Details zu den Risiken von Kokain oder MDMA gibt es in diesem Quarks Daily Spezial: https://www.quarks.de/podcast/koks-mdma-ketamin-und-speed-dieses-risiko-gehst-du-ein/ Und zur Sucht und Drogen Hotline geht es hier: https://www.bioeg.de/service/infotelefone/sucht-drogen-hotline/

Witam Państwa, nazywam się Jarosław Drożdż, pracuję w Centralnym Szpitalu Klinicznym Uniwersytetu Medycznego w Łodzi, skąd nagrywam podcast Kardio Know-How. W tym odcinku omawiam pierwszą część badań opublikowanych podczas kongresu ACC 2026. Od lat sprzeciwiam się wykonywaniu badań i procedur, co do których nie mam przekonania klinicznego. Przykładem jest pacjent z ciężką stenozą aortalną kwalifikowany do TAVI, u którego w angio CT wykryto istotne zwężenia wieńcowe. W takich przypadkach pojawiają się trzy pytania: czy robić koronarografię, czy rewaskularyzację i co wykonać najpierw. Badanie PRO-TAVI (https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(26)00308-9/abstract?rss=yes) analizowało sens wykonywania rewaskularyzacji przed TAVI. Porównano strategię PCI przed TAVI z podejściem bezpośredniego TAVI i nie wykazano istotnych różnic w zgonach, zawałach czy udarach. Jednocześnie strategia bez PCI oznaczała aż o 92% mniej rewaskularyzacji oraz wyraźnie mniej krwawień i powikłań. Aktualne wytyczne ESC/PTK 2025 ograniczają wskazania do rewaskularyzacji, szczególnie przy zwężeniach

The viral TikTok trend of fibermaxxing suggests you should eat between 50-100g/day of fiber, two to three times the recommended amount. Chris and Sophie delve into the evidence about whether it actually does lower cholesterol, prevent cancer, and boost your immune system. Also, two new faces join the team. Become a supporter of our show today either on Patreon or through PayPal! Thank you! http://www.patreon.com/thebodyofevidence/ https://www.paypal.com/donate?hosted_button_id=9QZET78JZWCZE   Email us your questions at thebodyofevidence@gmail.com.   Editor:    Robyn Flynn Producer: Sophie Tseng Pellar Theme music: “Fall of the Ocean Queen“ by Joseph Hackl Rod of Asclepius designed by Kamil J. Przybos Chris' book, Does Coffee Cause Cancer?: https://ecwpress.com/products/does-coffee-cause-cancer   Obviously, Chris is not your doctor (probably). This podcast is not medical advice for you; it is what we call information. References: Epidemiological studies showing lower disease risk: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(18)31809-9/fulltext https://www.bmj.com/content/347/bmj.f6879 https://jamanetwork.com/journals/jama/fullarticle/202011 https://pubmed.ncbi.nlm.nih.gov/40651334/ Fiber and cholesterol: https://pubmed.ncbi.nlm.nih.gov/30239559/ Fiber and weight loss: https://pubmed.ncbi.nlm.nih.gov/37163454/ Fiber and diabetes: https://pmc.ncbi.nlm.nih.gov/articles/PMC11155034/ Fiber and the microbiome: https://www.cell.com/cell/fulltext/S0092-8674(21)00754-6 Fiber and irritable bowel syndrome: https://www.bmj.com/content/339/bmj.b3154 Fiber and colon cancer: https://pubmed.ncbi.nlm.nih.gov/17855692/  

In this really interesting episode, Doctors Lisa and Sara talk to Dr Rageshri Dhairyawan - Consultant in Sexual Health and HIV Medicine, and Dr Laura Tinner - Research Fellow in Centre for Public Health, at Bristol University. Rageshri talks about her lived experience of being dismissed in a medical situation, despite her professional background and how this led to her researching the topic in depth, and writing a book on the subject. Laura speaks to a piece of research she carried out around the views of young women accessing medical care and explains that we need to put more emphasis on listening in healthcare. They both talk to the system pressures and challenges that lead to patients feeling dismissed, but also share practical advice and tips for what healthcare professionals can do to help certain groups of people feel more heard in healthcare. You can use these podcasts as part of your CPD - we don't do certificates but they still count :) Resources: Unheard - The Medical Practice of Silencing by Dr Rageshri Dhairyawan: https://amzn.eu/d/03u4y1DX Animation about a young women's experience of healthcare accessible through the embedded link on this site: https://ayph.org.uk/wp-content/uploads/2025/12/SHIFT-Improving-young-womens-care-resource-sheet.pdf The Association for Young People's Health: https://ayph.org.uk/ The Young Women's Movement: https://youngwomenscot.org/ Training session: Enquiries taken by Association for Young People's Health who have a 90-minute training course to healthcare professionals. It's co-delivered by young women who have been trained in facilitation skills and can be booked by groups of healthcare professionals who would benefit from training support related to delivering care to young women. The training uses the animation pillars to go through scenarios and exercises. Cost is dependent on whether delivered online or in person and whether any bespoke elements need to be included, but please get in touch to discuss what could work for you. Contact AYPH for more info: info@youngpeopleshealth.org.uk The Young Women's Movement:  EmBody to EmPower: https://youngwomenscot.org/resources/embody-to-empower/ Intersectional discrimination and mental health inequalities: a qualitative study of young women's experiences in Scotland: https://link.springer.com/article/10.1186/s12939-024-02133-3#citeas An exploration of discrimination in healthcare for young women in Scotland: An intersectional study: https://www.sciencedirect.com/science/article/pii/S2667321525000125 Fighting the “Bog Standard”: Intersectional experiences of gender and disability discrimination within healthcare among women in Scotland: https://www.sciencedirect.com/science/article/pii/S2667321526000119 Women's experiences of discrimination and the impact on health: https://www.gov.scot/publications/womens-experiences-discrimination-impact-health/ Reflect, collaborate, and listen: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)00251-X/abstract Listening is a tool for health equity, not just a soft skill: https://www.bmj.com/content/390/bmj.r1164.long Listening to the voices of the medically silenced: https://journals.plos.org/globalpublichealth/article?id=10.1371/journal.pgph.0003761 Scotland's Women's Health Plan: Phase Two: https://www.gov.scot/publications/womens-health-plan-phase-two-2026-2029/ Dr Jonathon Tomlinson's blog : https://abetternhs.net/about/ ___ We really want to make these episodes relevant and helpful: if you have any questions or want any particular areas covered then contact us on Twitter @PCKBpodcast, or leave a comment on our quick anonymous survey here: https://pckb.org/feedback Email us at: primarycarepodcasts@gmail.com ___ Given that this episode was recorded with specific clinicians, the information discussed may not be applicable elsewhere and it is important to consult local guidelines before making any treatment decisions.  The information presented is the personal opinion of the healthcare professional interviewed and might not be representative to all clinicians. It is based on their interpretation of current best practice and guidelines when the episode was recorded. Guidelines can change; To the best of our knowledge the information in this episode is up to date as of it's release but it is the listeners responsibility to review the information and make sure it is still up to date when they listen. Dr Lisa Adams, Dr Sara MacDermott and their interviewees are not liable for any advice, investigations, course of treatment, diagnosis or any other information, services or products listeners might pursue as a result of listening to this podcast - it is the clinicians responsibility to appraise the information given and review local and national guidelines before making treatment decisions. Reliance on information provided in this podcast is solely at the listeners risk. The podcast is designed to be used by trained healthcare professionals for education only. We do not recommend these for patients or the general public and they are not to be used as a method of diagnosis, opinion, treatment or medical advice for the general public. Do not delay seeking medical advice based on the information contained in this podcast. If you have questions regarding your health or feel you may have a medical condition then promptly seek the opinion of a trained healthcare professional.

Välkomna till 2026 års första Internisten podcast - denna gång om diabetes med fantastiska Peter Fors! Artiklarna som diskuteras är: Gammalt: Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34), UKPDS Group, 1998, Lancet. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(98)07037-8/abstract Nytt: Euglycemic diabetic ketoacidosis: Rising incidence, diagnostic delays, and the impact of SGLT2 inhibitors in hospitalized patients. Schutte et al. Journal of Hospital Medicine. 2025. https://shmpublications.onlinelibrary.wiley.com/doi/10.1002/jhm.70015 Udda: An Atypical Form of Diabetes Among Individuals With Low BMI. Lontchi-Yimagou et al. Diabetes Care. 2022. https://pmc.ncbi.nlm.nih.gov/articles/PMC9184261/pdf/dc211957.pdf Hör gärna av er med feedback till joseph.aked@gmail.com. Har ni något ämne eller gästexpert ni vill höra i podden så tas tips tacksamt emot! På återhörande före sommaren med nytt ämne!

Introducing Brain Bytes, a new micro-cast hosted by Kelly Tremblay, PhD, neuroscientist, World Health Organization advisor, NIH grant reviewer, advocate, and professor. Brain Bytes features "byte"-sized nuggets of knowledge aimed at making neuroscience accessible for the senior living world.  In each episode, which will air on the fourth Friday of each month, Dr. Tremblay will share research-backed information related to aging and brain health. This week, she explores the different types of dementia and examines what evidence-based researchtells us about it. While encouraging listeners to take practical steps to support healthy aging, Dr. Tremblay explains that a significant portion of dementia risk may be modifiable. Factors such as education, physical activity, cardiovascular health, hearing and vision care, and social connection all play a role in supporting brain health across the lifespan. The following links accompany today's episode: • https://www.nia.nih.gov/health/alzheimers-and-dementia • https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)01296-0/abstract • https://www.thelancet.com/infographics-do/dementia-risk We are grateful to Parker Health for their sponsorship of this micro-cast.

Season 9 is off to an exceptionally strong start with our recent discussion with Dr. Nicholas Freudenberg, Distinguished Professor Emeritus of Public Health at the City University of New York (CUNY) School of Public Health. Dr. Freudenberg is Senior Faculty Fellow and co-founder of the CUNY Urban Food Policy Institute (www.cunyurbanfoodpolicy.org). He is a leading expert in Commercial Determinants of Health, authoring two key books in the field; At What Cost: Modern Capitalism and the Future of Health (Oxford, 2021) and Lethal but Legal: Corporations, Consumption, and Protecting Public Health (Oxford, 2014 and 2016). He was a contributor to the landmark Lancet series on the topic: https://www.thelancet.com/series-do/commercial-determinants-health.Commercial Determinants of Health can be understood as the ways that market actors influence health and disease globally. Commercial Determinants of Health are related to Social Determinants of Health and Political Determinants of Health, which together form a system that influences patterns of human health and disease. The term developed in the early 2000s, emerging from an earlier concept of Corporate Determinants of Health, recognizing that a small number of multinational global corporations dominate the world economy. Dr. Freudenberg explains that changing behavior of businesses and corporations can achieve public health gains at a much greater scale that traditional individual behavioral change approaches, citing successful policies regulating the tobacco industry and smaller gains changing the business opportunities to favor alternatives to the fossil fuel industry. One of the largest commercial determinants of health is the food industry, where there are multiple opportunities for change. Dr. Freudenberg discusses the importance of coordination between activists and public health professionals to counterbalance the influence of corporations on policy. What is the role of bioethicists? Listen and find out! Bibliography:https://www.annualreviews.org/content/journals/10.1146/annurev-publhealth-052220-020447https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)00011-9/abstracthttps://global.oup.com/academic/product/at-what-cost-9780190078621?cc=us&lang=en&https://global.oup.com/academic/product/lethal-but-legal-9780199937196?cc=us&lang=en&

In this episode Andrea Samadi interviews Thoryn Stevens, CEO and founder of Brain.One, about using AI, wearables, biomarkers and evidence-based micro-habits to create personalized brain-health protocols. Watch our full interview on YouTube here https://www.youtube.com/watch?v=r9UN9kev2CE or listen and follow the show notes here https://andreasamadi.podbean.com/e/can-ai-personalize-your-brain-health-inside-brainones-protocols/  What We Covered on EP 386 with Thoryn Stephens The Problem with Generic Wellness Advice Why most health advice fails to translate into sustained behavior change The gap between research findings and real-world application Why optimization must be systematic, not inspirational From Data to Daily Micro-Habits How Brain.One analyzes peer-reviewed research using AI Turning biometrics (HRV, sleep data, metabolic markers) into actionable protocols Why small, consistent micro-habits compound into long-term neuroplastic change Wearables & What Actually Matters The most misunderstood wearable metrics HRV, sleep architecture, and recovery as early indicators of cognitive health How to avoid becoming obsessive with numbers while still using data intelligently Dementia Prevention & Cognitive Longevity Evidence-based strategies inspired by the Lancet dementia prevention framework Why metabolic health and inflammation play a critical role in brain aging Prevention vs. reversal: when to start optimizing brain health Biological Bottlenecks to Human Potential Stress dysregulation as a performance limiter Sleep architecture and glymphatic clearance Metabolic flexibility and mitochondrial function Why emotional regulation remains foundational to cognitive performance AI in Health: Hype vs. Evidence What makes Brain.One's system evidence-constrained How AI can scale personalized health protocols The future of data-driven behavioral optimization

Problems with the PREVENT score, a breakthrough in lipid-lowering therapy, a surprising benefit in stroke care, and more thoughts on statins and preventive care of heart disease are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I PREVENT Score PREVENT Equations in Young Adults https://doi.org/10.1016/j.jacc.2025.12.019 Hospital Readmission Reduction Program for HF https://pmc.ncbi.nlm.nih.gov/articles/PMC7664458/ II A New Breakthrough in LDL-C Management With an Oral PCSK9 Inhibitor https://www.medscape.com/viewarticle/time-overcome-pcsk9i-inertia-new-data-future-options-2025a1000wf8 CORALreef Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2511002 CORALreef Outcomes Trial https://clinicaltrials.gov/study/NCT06008756 III A Win for the Factor XI Inhibitor Asundexian – OCEANIC Stroke Trial https://www.medscape.com/viewarticle/first-clear-win-factor-xia-inhibitors-stroke-reduced-2026a10003t0 OCEANIC-STROKE Slide deck https://clinicaltrialresults.org/wp-content/uploads/2026/02/26-02-02_ISC_OCEANIC-STROKE-primary.pdf OCEANIC-AF Study Stopped Early https://www.bayer.com/media/en-us/oceanic-af-study-stopped-early-due-to-lack-of-efficacy/ IV Statin Side Effects Assessment of AEs Attributed to Statins -- Meta-analysis https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)01578-8/fulltext N-of-1 Trial to Assess AEs of Statins https://www.nejm.org/doi/full/10.1056/NEJMc2031173 When to Start a Statin Is a Decision About Preference -- Editorial https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.117.029808 V Heart Disease Statistics CV Statistics in the US, 2026 https://www.jacc.org/doi/10.1016/j.jacc.2025.12.027 You may also like: The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net

Listener feedback, huge news in the rapidly expanding world of PFA AF Ablation, obesity, and a beautiful trial studying an AI-enhanced diagnostic tool in the office are the topics discussed by John Mandrola, MD, in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I Listener Feedback Risk-Based TEE Omission in PVI 10.1016/j.hrthm.2025.04.056 External Link II PFA News BEAT PAROX-AF trial https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehaf1115/8436829 Life-Threatening Delayed Myocardial Ischemia and Malignant Arrhythmias Occurring After PFA https://www.ahajournals.org/doi/full/10.1161/CIRCULATIONAHA.125.077983 Heart Rhythm TV: Life-Threatening Delayed Myocardial Ischemia and Malignant Arrhythmias  https://www.youtube.com/watch?v=M-npoLKmRa4 MAUDE Adverse Event report https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfmaude/detail.cfm?mdrfoi__id=23733351&pc=QZI III Obesity trends US State-Level Obesity Trends 1990-2022 and Forecasted to 2035 https://jamanetwork.com/journals/jama/fullarticle/2844495 IV New Tools in the Office TRICORDER Trial https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)02156-7/fulltext You may also like: The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net

Ursodiol (ursodeoxycholic acid) is a prescription bile acid medication used to dissolve cholesterol gallstones, prevent gallstones during rapid weight loss, and treat liver diseases like primary biliary cholangitis (PBC) by reducing toxic bile acids and cholesterol production. It works by changing bile composition, making it less saturated with cholesterol, and is available as oral medication. Of course, it is also the foundational medication for treatment of diagnosed Intrahepatic Cholestasis of Pregnancy (ICP). Does this medication reduce adverse perinatal outcomes? In this episode, we will review a new study from the Green Journal, which will be out in February 2026, examining the recurrence risk for ICP using data from NY. In a patient with prior history of ICP, is there any guidance on monitoring of serum bile acids in the subsequent pregnancy before symptoms develop? We will explain. PLUS we will review the data on whether Ursodiol may hold promise in recurrence prevention or in reduction of adverse outcomes once the condition is diagnosed. Listen in for details. 1. 2019: Chappell LC, Bell JL, Smith A, Linsell L, Juszczak E, Dixon PH, Chambers J, Hunter R, Dorling J, Williamson C, Thornton JG; PITCHES study group. Ursodeoxycholic acid versus placebo in women with intrahepatic cholestasis of pregnancy (PITCHES): a randomised controlled trial. Lancet. 2019 Sep 7;394(10201):849-860. doi: 10.1016/S0140-6736(19)31270-X. Epub 2019 Aug 1. PMID: 31378395; PMCID: PMC6739598. https://pubmed.ncbi.nlm.nih.gov/31378395/2. February 08, 2025: Rahim, Mussarat N et al. Pregnancy and the liver. The Lancet. 2021; Volume 405, Issue 10477, 498 – 513 https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)02351-1/fulltext3. SMFM CS 53; 20214. Rosenberg, Henri M. MD; Sarker, Minhazur R. MD; Ramos, Gladys A. MD; Bianco, Angela MD; Ferrara, Lauren MD; DeBolt, Chelsea A. MD. Intrahepatic Cholestasis of Pregnancy Recurrence in a Subsequent Pregnancy. Obstetrics & Gynecology 147(2):p 239-241, February 2026. | DOI: 10.1097/AOG.0000000000006033 https://journals.lww.com/greenjournal/fulltext/2026/02000/intrahepatic_cholestasis_of_pregnancy_recurrence.13.aspx5. Ovadia C, Sajous J, Seed PT et al. Ursodeoxycholic acid in intrahepatic cholestasis of pregnancy: a systematic review and individual participant data meta-analysis. Lancet Gastroenterol Hepatol. 2021 Jul;6(7):547-558. doi: 10.1016/S2468-1253(21)00074-1. Epub 2021 Apr 27. PMID: 33915090; PMCID: PMC8192305.6. EASL Clinical Practice Guidelines on the management of liver diseases in pregnancy. European Association for the Study of the Liver; 2023

The limits of knowing coronary artery disease anatomy, fish oil and AF risk, a new drug for PSVT, and maybe I was wrong about a drug for AF conversion (the RAFF4 trial). These are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I Prediction of CAD is hard — even if you have anatomy CCTA in Prediction of First Coronary Events https://jamanetwork.com/journals/jama/fullarticle/2841255 II Fish Oil and AF (and as a bonus we learn again about analytic flexibility) Are Fish Oils on the Hook for AF Risk? https://www.medscape.com/viewarticle/995290 Omega-3 and Fish Oil Use With Risk of AF  https://www.ahajournals.org/doi/full/10.1161/JAHA.125.043031 Effect of Long-Term Marine Omega-3 Fatty Acids on the Risk of AF https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.121.055654 RESPECT-EPA Trial https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.123.065520 Association Between Omega-3 Fatty Acids and AF: Meta Analysis https://link.springer.com/article/10.1007/s10557-021-07204-z Fish Oil Supplements and Risk of AF https://academic.oup.com/eurjpc/article/29/14/1911/6679610 Editorial: Fish Oil Supplements and AF Risk https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.121.057464 III A New Drug for PSVT FDA Approval https://www.fda.gov/drugs/news-events-human-drugs/fda-approves-drug-type-abnormally-fast-heart-rhythm RAPID trial https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)00776-6/fulltext IV AF Conversion with Vernakalant RAFF4 Trial https://www.bmj.com/content/391/bmj-2025-085632.long Editorial: Rapid Cardioversion for Acute AF https://www.bmj.com/content/391/bmj.r2264 VI A Quick Note on HFpEF Med Op-Ed: Avalanche Survival, HFpEF Skepticism, and More https://www.medscape.com/viewarticle/med-op-ed-avalanche-survival-hfpef-skepticism-and-more-2026a1000012 You may also like: The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net

Is the open thoracotomy becoming outdated as robotic surgery and advanced ablation techniques take center stage in lung cancer treatment? In the final discussion of the 2025 NSCLC Creator Weekend™ series, our virtual tumor board of interventional radiologists and pulmonologists from leading medical institutions discuss recent surgical and interventional advancements in the treatment of lung cancer. --- This podcast is supported by an educational grant from Johnson & Johnson and Varian. --- SYNPOSIS The conversation covers the contemporary role of PET scans, endobronchial ultrasound (EBUS), mediastinal staging, and the importance of perioperative systemic therapy. The doctors explore surgical and non-surgical methods for treating lung cancer, including lymph node dissection, criteria for resection, and the advantages of minimally invasive approaches such as video-assisted thoracoscopic surgery (VATS) and robotic-assisted surgeries.A key focus of this episode is the decision-making process for treating multifocal lung cancers while preserving lung function, and the use of combined therapies like ablation and radiation. The episode concludes with a detailed case study illustrating the long-term management of a patient with multiple lung adenocarcinomas over several years, highlighting the multidisciplinary approach required in such complex scenarios. --- TIMESTAMPS 00:00 - Introduction10:07 - Patient Selection and Comorbid Conditions27:29 - Surgical Margins and Resection Strategies42:11 - Understanding Upstaging in Cancer Treatment53:27 - Technical and Clinical Resectability56:13 - Case Study: Managing Multifocal Lung Cancer01:11:41 - Long-Term Outcomes and Treatment Strategies --- RESOURCES CALGB 140503 Trialhttps://www.nejm.org/doi/full/10.1056/NEJMoa2212083 JCOG0802 Trialhttps://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)02333-3/abstract

De repente surge a voz da Simone cantando "Então é Natal", ou a da Mariah Carey dizendo que "All I Want for Christmas Is You", e bate aquela bad... Afinal, por que o fim do ano deixa a gente mais triste ou reflexivo ou ambos? A ciência explica?Confira o papo entre o leigo curioso, Ken Fujioka, e o cientista PhD, Altay de Souza.>> OUÇA (61min 01s)* Naruhodo! é o podcast pra quem tem fome de aprender. Ciência, senso comum, curiosidades, desafios e muito mais. Com o leigo curioso, Ken Fujioka, e o cientista PhD, Altay de Souza.Edição: Reginaldo Cursino.http://naruhodo.b9.com.br*APOIO: INSIDERIlustríssima ouvinte, ilustríssimo ouvinte do Naruhodo, O Natal está aí e o que a gente mais precisa nessa época é de um jeito prático e inteligente de fazer as compras de fim de ano.Por isso, minha dica não podia ser outra: presenteie com INSIDER.Afinal, só INSIDER garante:- presentes inteligentes- compra sem sair de casa- troca simplificada- e o mais importante: não tem erro, é certeza de que vai agradar.Em dezembro, seu desconto total pode chegar a 30%, combinando o cupom NARUHODO com os descontos do site.É isso mesmo: até 30% de desconto total.E mais: você ainda ganha 20% de cashback pra usar na próxima compra.Então use o endereço a seguir pra já ter o cupom NARUHODO aplicado ao seu carrinho de compras:>>> creators.insiderstore.com.br/NARUHODOE feliz Natal!INSIDER: inteligência em cada escolha.#InsiderStore*REFERÊNCIASSelf-Validation Theory: An Integrative Framework for Understanding When Thoughts Become Consequentialhttps://psycnet.apa.org/fulltext/2022-16687-001.htmlFalse polarization: Cognitive mechanisms and potential solutionshttps://www.sciencedirect.com/science/article/abs/pii/S2352250X21000749?casa_token=SO99hoSW2t8AAAAA:_o1EyNxsHhvk2PzZhTce9W1bBWcqnA6QmxEPH-WgEfW5E0p_NBQYDg7f-TG2ClAPRPq6ZrhVKgHow Stress, Trauma, and Emotion May Shape Post-Conflict Environments – with Implications for International Peacekeeping https://www.tandfonline.com/doi/abs/10.1080/13533312.2024.2321434?casa_token=odhn7Wk-AqQAAAAA:9RNPgIsU24U_C40DoxVw70YdzxdJfRI5vOaobgWCR8G_fA7P2U9DdRzwzFURrbSZq9F0zntwTwQCEmotional Processes in Intractable Conflicts https://academic.oup.com/edited-volume/51639/chapter-abstract/418868699?redirectedFrom=fulltextCan Sadness Be Good for You? https://www.tandfonline.com/doi/abs/10.1111/ap.12232Knowledge of Sadness: Emotion-related behavioral words differently encode loss and failure sadnesshttps://link.springer.com/article/10.1007/s12144-018-0010-9?fromPaywallRec=trueThe bright side of being blue: Depression as an adaptation for analyzing complex problems.https://psycnet.apa.org/record/2009-10379-009Major Depression and Its Recurrences: Life Course Matters https://www.annualreviews.org/content/journals/10.1146/annurev-clinpsy-072220-021440Success, Happiness, and the Value of Sadnesshttps://link.springer.com/chapter/10.1007/978-3-031-99782-2_4Positive potential of a sad experiencehttps://www.thelancet.com/journals/lancet/article/PIIS0140-6736(05)75258-2/fulltextSadness, the Architect of Cognitive Changehttps://link.springer.com/chapter/10.1007/978-3-319-77619-4_4The Good, the Bad, and the Rare: Memory for Partners in Social Interactionshttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0018945The Temporal Dynamics of Opportunity Costs: A Normative Account of Cognitive Fatigue and Boredomhttps://psycnet.apa.org/fulltext/2021-74505-001.html?casa_token=hM1BXaRnrLkAAAAA:PbkY0NuOyCVrvxv62KHlF8F0Bs7nRVoqm1eenoukmnU1vljzG5bffcMv_h-uAAM6wcD5g_o7YNZGxHGQ5GbqzXUThe Other Side of Sadnesshttps://books.google.com.br/books?hl=en&lr=&id=AEiRDwAAQBAJ&oi=fnd&pg=PT8&dq=a+bright+side+of+sadness&ots=TyvGk7OTyw&sig=YMMWntIBZHmNuPjjiUWvuejGzD0&redir_esc=y#v=onepage&q=a%20bright%20side%20of%20sadness&f=falseNaruhodo #411 - Por que traímos? - Parte 1 de 2https://www.youtube.com/watch?v=kVruX3MhxigNaruhodo #412 - Por que traímos? - Parte 2 de 2https://www.youtube.com/watch?v=Towh8afX65YNaruhodo #206 - Por que choramos?https://www.youtube.com/watch?v=zWorZ-zK-c4Naruhodo #261 - O que a solidão pode causar nas pessoas?https://www.youtube.com/watch?v=02dPRPGcqVsNaruhodo #363 - Jejum de dopamina funciona?https://www.youtube.com/watch?v=908qoFZG8rYNaruhodo #238 - O distancionamento social impacta a nossa saúde mental? - Parte 1 de 2https://www.youtube.com/watch?v=SHKiDA21UvcNaruhodo #441 - Existe crise da meia idade?https://www.youtube.com/watch?v=jiY76AnQ4E8Naruhodo #39 - A ignorância é uma benção?https://www.youtube.com/watch?v=MIKhzU6VNy8Naruhodo #357 - Existe possibilidade de consenso na polarização?https://www.youtube.com/watch?v=KhyKRnhjnbwNaruhodo #430 - Por que é tão difícil deixar o rancor de lado?https://www.youtube.com/watch?v=u0IesoD4A9ANaruhodo #446 - O que é transfuga de classe?https://www.youtube.com/watch?v=HQQyT1sawZoNaruhodo #424 - O que é competitividade? - Parte 1 de 2https://www.youtube.com/watch?v=noPHBDvkDUcNaruhodo #425 - O que é competitividade? - Parte 2 de 2https://www.youtube.com/watch?v=bMkLimosW0ENaruhodo #454 - O que é burnout e como lidar com ele?https://www.youtube.com/watch?v=YHMFWZQ2ak4Naruhodo #239 - O distancionamento social impacta a nossa saúde mental? - Parte 2 de 2https://www.youtube.com/watch?v=1Ya1lx7sueQNaruhodo #235 - Por que suspiramos?https://www.youtube.com/watch?v=Obh8T90AefANaruhodo #275 - Por que sorrimos?https://www.youtube.com/watch?v=DhyeVD1gtjINaruhodo #259 - Por que as coisas parecem óbvias depois que passamos por elas? - Parte 1 de 2https://www.youtube.com/watch?v=fsgAdq_iu-ANaruhodo #260 - Por que as coisas parecem óbvias depois que passamos por elas? - Parte 2 de 2https://www.youtube.com/watch?v=jWTaLWjT-ZUNaruhodo #378 - Por que avisos de perigo não são seguidos?https://www.youtube.com/watch?v=lKabJ3lQOHUNaruhodo #155 - Tomar decisões cansa o nosso cérebro?https://www.youtube.com/watch?v=tqEfVCT4dGoNaruhodo #379 - Como nós nos tornamos nós?https://www.youtube.com/watch?v=fI9rqAJfcUUNaruhodo #246 - O que os outros esperam de nós nos torna melhores?https://www.youtube.com/watch?v=q_AK3hUlJVwNaruhodo #450 - A inteligência artificial afeta nossa capacidade cognitiva?https://www.youtube.com/watch?v=YjMTEGrgHDwNaruhodo #443 - Quais os impactos dos robôs em nossas vidas? - Parte 1 de 2https://www.youtube.com/watch?v=tCUsvZ9hQ60Naruhodo #444 - Quais os impactos dos robôs em nossas vidas? - Parte 2 de 2https://www.youtube.com/watch?v=yLVhdONlrugNaruhodo #442 - Qual o efeito da arte sobre nós?https://www.youtube.com/watch?v=9pgyTDtRbeoNaruhodo #342 - O que é e de onde vem a inspiração?https://www.youtube.com/watch?v=Xg0vGC-uPwMNaruhodo #395 - O que é força de vontade?https://www.youtube.com/watch?v=5bR1RNVo7kMNaruhodo #396 - O que fazer frente ao aquecimento global?https://www.youtube.com/watch?v=RchVGabxOdoNaruhodo #407 - Existe razão sem emoção?https://www.youtube.com/watch?v=qUxluRrHV3ENaruhodo #340 - Como se constrói a auto-estima?https://www.youtube.com/watch?v=0ULx-CXmh7wNaruhodo #220 - Existe causa para a depressão? - Parte 1 de 2https://www.youtube.com/watch?v=cFo8GFwyuR0Naruhodo #221 - Existe causa para a depressão? - Parte 2 de 2https://www.youtube.com/watch?v=5peXBmG43lUNaruhodo #165 - Quando tomo antidepressivos continuo sendo eu mesmo?https://www.youtube.com/watch?v=dWyfUyHUiA4Naruhodo #404 - Por que algumas pessoas gostam de terminar as coisas e outras não?https://www.youtube.com/watch?v=pTSZ--4TKMkNaruhodo #393 - A psicologia positiva tem validade científica? - Parte 1 de 2https://www.youtube.com/watch?v=LnSZCHHfoWINaruhodo #394 - A psicologia positiva tem validade científica? - Parte 2 de 2https://www.youtube.com/watch?v=n8h3zC7YLNNaruhodo #406 - As fases do luto têm validade científica?https://www.youtube.com/watch?v=VltGGsSfNsI*APOIE O NARUHODO!O Altay e eu temos duas mensagens pra você.A primeira é: muito, muito obrigado pela sua audiência. Sem ela, o Naruhodo sequer teria sentido de existir. Você nos ajuda demais não só quando ouve, mas também quando espalha episódios para familiares, amigos - e, por que não?, inimigos.A segunda mensagem é: existe uma outra forma de apoiar o Naruhodo, a ciência e o pensamento científico - apoiando financeiramente o nosso projeto de podcast semanal independente, que só descansa no recesso do fim de ano.Manter o Naruhodo tem custos e despesas: servidores, domínio, pesquisa, produção, edição, atendimento, tempo... Enfim, muitas coisas para cobrir - e, algumas delas, em dólar.A gente sabe que nem todo mundo pode apoiar financeiramente. E tá tudo bem. Tente mandar um episódio para alguém que você conhece e acha que vai gostar.A gente sabe que alguns podem, mas não mensalmente. E tá tudo bem também. Você pode apoiar quando puder e cancelar quando quiser. O apoio mínimo é de 15 reais e pode ser feito pela plataforma ORELO ou pela plataforma APOIA-SE. Para quem está fora do Brasil, temos até a plataforma PATREON.É isso, gente. Estamos enfrentando um momento importante e você pode ajudar a combater o negacionismo e manter a chama da ciência acesa. Então, fica aqui o nosso convite: apóie o Naruhodo como puder.bit.ly/naruhodo-no-orelo

IN this episode, Dr's J and Santhosh cover stories, studies, and general knowledge in their annual influenza special. Along the way they cover the poor decision making of the secretary for health and human services, the confluence of influenza and journal clubs, the original identification and discovery of the flu virus, a sneezy ferret, optimistic media, military vaccine testing, the discovery of seasonal flu changes, the art of flu surveillance, the damage done to surveillance by this administration, alternative vaccine production methods, dosing change recommendations and more! so sit back and catch some knowledge about whats coming to town!Further Readinghttps://utppublishing.com/doi/10.3138/jammi-2025-0025https://www.cdc.gov/fluview/surveillance/2025-week-45.htmlhttps://www.nejm.org/doi/full/10.1056/NEJMoa2416779?query=featured_homehttps://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)01742-8/abstracthttps://www.ijidonline.com/article/S1201-9712(25)00322-4/fulltextSupport Us spiritually, emotionally or financially here! or on ACAST+travelmedicinepodcast.comBlueSky/Mastodon/X/Instagram: @doctorjcomedy @toshyfroTikotok: DrjtoksmedicineGmail: travelmedicinepodcast@gmail.comSpotify: https://open.spotify.com/show/28uQe3cYGrTLhP6X0zyEhTPatreon: https://www.patreon.com/travelmedicinepodcast Hosted on Acast. See acast.com/privacy for more information.

An elegant study in post-TAVI atrioventricular block, a PSA for my structural colleagues, revascularization in women, and a CTO PCI trial are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I AV Block After TAVR Heart Blocks During vs After TAVR Show Distinct Patterns https://www.medscape.com/viewarticle/heart-blocks-during-vs-after-tavr-show-distinct-patterns-2025a1000ypp Mechanisms Underlying Alterations in Cardiac Conduction After TAVR https://jamanetwork.com/journals/jamacardiology/fullarticle/2842748 II Related PSA Announcement to My Structural Colleagues III Revascularization Strategies in Women with Severe Chronic CAD Women With Chronic Severe CAD Fare Better With CABG vs PCI https://www.medscape.com/viewarticle/women-chronic-severe-cad-fare-better-cabg-vs-pci-2025a1000ygd PCI vs CABG in Women With Chronic CAD https://doi.org/10.1093/eurheartj/ehaf806 PCI vs CABG - Meta-Analysis of 4 RCTs https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)02334-5/abstract CABG vs Drug-Eluting Stent Implantation for CAD - Meta-Analysis https://www.jacc.org/doi/10.1016/j.jcin.2016.10.008 RECHARGE trial https://therechargetrial.com/ IV A CTO PCI RCT – But don't get your hopes up Early vs Late-Staged PCI After Subintimal Tracking and Re-entry for CTO https://doi.org/10.1016/j.jacc.2025.09.1598 DECISION CTO trial https://pubmed.ncbi.nlm.nih.gov/30813758/ National Inpatient Sample Database PCI CTO Associated With Higher Mortality https://pubmed.ncbi.nlm.nih.gov/37356643/ V Mandrola's Top 10 Stories You may also like: The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net

What happens when the brain flatlines - yet consciousness continues?In this episode of Mind-Body Solution, Dr Tevin Naidu speaks with world-renowned cardiologist and pioneering near-death experience (NDE) researcher Dr Pim van Lommel. His groundbreaking Lancet study remains one of the most rigorously documented clinical investigations into NDEs - and its implications challenge our deepest assumptions about the mind, the brain, and the nature of reality.We explore:• The medical evidence for consciousness during cardiac arrest• Why the brain cannot account for NDEs• The transceiver/filter model of consciousness• Out-of-body perceptions verified during resuscitation• Why materialism may be scientifically untenable• The long-term personality transformation following NDEs• Implications for neuroscience, medicine, ethics, and the mind-body problem• What dying actually feels like• Why Pim now views death as “a transition, not an end”This is one of the most comprehensive, medically grounded explorations of non-local consciousness available today. Whether you're a skeptic, scientist, philosopher, or simply curious, this conversation forces a radical re-examination of what consciousness is.TIMESTAMPS:(00:00) – Introduction(01:00) – Consciousness & Near Death Experiences (NDEs)(05:06) – Findings from the landmark 2001 Lancet study(09:10) – Out-of-body experiences (OBEs) & verified accounts(10:42) – Consciousness beyond the brain: receiver model(19:25) – Memory, identity & self without the body(20:25) – Universal NDE elements & what they imply(29:08) – Critics, skeptics & scientific resistance(31:23) – Why consciousness cannot be measured(32:46) – Monism? Dual-aspect? Idealism? Pim's stance(35:56) – Implications for medical ethics & end-of-life care(37:56) – Deathbed phenomena & after-death communication(42:08) – Telepathy, remote viewing & “non-local” psychology(45:24) – Quantum physics: analogy not explanation(48:28) – The next generation of researchers(50:06) – What death really is and isn't(51:27) – Is there purpose to the universe?(54:42) – Psychedelics vs NDEs: crucial differences(58:00) – Where does Pim believe he will go after death?(1:01:20) – Final reflectionsEPISODE LINKS:- Pim's Website: https://pimvanlommel.nl/en/- 2001 Lancet Study: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(01)07100-8/abstract- Consciousness Beyond Life: https://www.amazon.com/Consciousness-Beyond-Life-Near-Death-Experience/dp/0061777250CONNECT:- Website: https://mindbodysolution.org - YouTube: https://youtube.com/@MindBodySolution- Podcast: https://creators.spotify.com/pod/show/mindbodysolution- Twitter: https://twitter.com/drtevinnaidu- Facebook: https://facebook.com/drtevinnaidu - Instagram: https://instagram.com/drtevinnaidu- LinkedIn: https://linkedin.com/in/drtevinnaidu- Website: https://tevinnaidu.com=============================Disclaimer: The information provided on this channel is for educational purposes only. The content is shared in the spirit of open discourse and does not constitute, nor does it substitute, professional or medical advice. We do not accept any liability for any loss or damage incurred from you acting or not acting as a result of listening/watching any of our contents. You acknowledge that you use the information provided at your own risk. Listeners/viewers are advised to conduct their own research and consult with their own experts in the respective fields.

Send us a textIn this episode of CLOT Conversations, co-hosts Dr. Jamil Abdul-Rahman and Dr. Maha Othman have an in-depth discussion with leading thrombosis expert Dr. Jeff Weitz. Together, they unpack new findings from The Lancet on RGN-9933 and RGN-7508, two investigational factor XI inhibitors evaluated in the ROXI-VTE I and II phase-2 trials. These studies examine how targeted inhibition of factor XI may reduce post-operative venous thromboembolism with potentially lower bleeding risk than current anticoagulants.Dr. Weitz explains the distinct mechanisms of the two antibodies, the role of factor XII-mediated activation in post-operative VTE, key efficacy and safety outcomes, and how these early-phase studies set the stage for ongoing phase-2 and phase-3 trials—including ROXI-CATH, ROXI-Aspirin, and emerging AF and stroke-prevention research.This episode is essential listening for clinicians interested in the rapidly evolving landscape of anticoagulation and next-generation therapies that may offer safer options for patients undergoing orthopedic surgery and beyond.Read the full Lancet publication by clicking on the link below and explore more thrombosis resources at thrombosiscanada.ca.Become a Thrombosis Champion, be a monthly donor at https://thrombosiscanada.ca/donatehttps://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)02097-5/abstract [Note: full access requires a subscription]Support the showhttps://thrombosiscanada.caTake a look at our healthcare professional and patient resources, videos and publications on thrombosis from the expert members of Thrombosis Canada

Dr. Patrick Schröder, a senior research fellow at Chatham House, assesses the progress and barriers for circular economy policymaking. Patrick Schröder specializes in the circular economy, climate change, resource governance, and the Sustainable Development Goals (SDGs). His work brings together science, policy, and media to help further evidence-based policies, communicate complex sustainability issues, and promote equitable governance solutions at the multilateral level. Patrick is currently the Coordinating Lead Author for one of the three working groups for the IPCC Assessment Report 7, reporting on Mitigation of Climate Change, and he is also the Coordinating Lead Author for the UN Global Environment Outlook 7. Patrick holds a PhD in Environmental Studies, and is now studying part-time for a second PhD in circular and regenerative design with the Centre for Sustainable Design. In 2024, UNIDO and Chatham House published a ground-breaking global stocktake of 75 national circular economy roadmaps featuring more than 2,800 policy actions. The first roadmap, from Japan, was published in 1999, and since 2016, as governments strive to accelerate their circular transitions, over 70 countries have published national circular economy roadmaps and strategies. The review aims to ‘bridge knowledge gaps and shed light on critical aspects of these publications', and the authors point to a ‘significant lack of focus on the need to ensure a just and inclusive' transition, warning that a ‘lack of recognition of the need to work collaboratively with the global community' risks derailing a global just transition. Patrick tells us how he currently sees the global state of play for circular economy policies and roadmaps, where progress is happening and from a policymaking perspective, what is holding it back. The team at Chatham House have created a micro-site – circulareconomy.earth – and Patrick tells us more about that, and how we can use it. Stay in touch for free insights and updates…  Read on for more on our guest and links to the people, organisations and other resources we mention. Links we mention in the episode: Links for our guest: DISCOUNT CODE for A Circular Economy Handbook: How to Build a More Resilient, Competitive and Sustainable Business https://www.koganpage.com/CircEcon3 buy direct from the publisher Kogan Page, which ships worldwide (free shipping to UK and US) and you can use discount code KOGANPAGE25 for 25% off the book. This offer also applies to Kogan Page’s bundle option (print plus e-book for the same price as the print edition).  Read more about the book and download the Introduction: circulareconomyhandbook.com Read more about Patrick Schröder: https://www.chathamhouse.org/about-us/our-people/patrick-schroder Patrick Schröder's publications on Google scholar: https://scholar.google.com/citations?user=xeaCha8AAAAJ&hl=en Patrick Schröder on Linkedin: https://www.linkedin.com/in/patrick-schr%C3%B6der-b5789119/?originalSubdomain=uk The circular economy global policy microsite: circulareconomy.earth Books, people and organisations we mentioned The Chatham House paper launched during the Summit of the Future in NY:https://www.chathamhouse.org/2024/09/how-circular-economy-can-revive-sustainable-development-goals Patrick's paper on the SDGs and Circular Economy in the Journal of Industrial Ecology: https://www.researchgate.net/profile/Patrick-Schroeder-9/publication/344220320_The_Relevance_of_Circular_Economy_Practices_to_the_Sustainable_Development_Goals/links/5f85b316458515b7cf7c9143/The-Relevance-of-Circular-Economy-Practices-to-the-Sustainable-Development-Goals.pdf Human Development and Circular Economy paper (co-authored by Patrick Shroeder with Peter Desmond and Alex Lemile): https://www.sciencedirect.com/science/article/abs/pii/S0921344920300082 The Lancet Countdown on health and plastics https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)01447-3/abstract Episode 166 Circularity Gap Report 2025: insights https://www.rethinkglobal.info/166-circularity-gap-report-2025-insights/   Episode 119 Ken Webster: the circular ECONOMY https://www.rethinkglobal.info/119-ken-webster-the-circular-economy/ Episode 119 Bonus Ken Webster: the circular ECONOMY! Part 2 https://www.rethinkglobal.info/119-bonus-ken-webster-the-circular-economy-part-2/ Guest bio Patrick Schröder is a senior research fellow at Chatham House. He specializes in the circular economy, climate change, resource governance, and the Sustainable Development Goals (SDGs).  He works at the intersection of science, policy, and media to advance evidence-based policies, communicate complex sustainability issues, and promote equitable governance solutions at the multilateral level. He currently serves as Coordinating Lead Author for the IPCC Assessment Report 7 (WG III – Mitigation) and Coordinating Lead Author for the UN Global Environment Outlook 7. He holds a PhD in Environmental Studies from Victoria University of Wellington, NZ, and currently studies part-time for a second PhD in circular and regenerative design with the Centre for Sustainable Design. Chatham House – The Royal Institute of International Affairs – is a world-leading policy institute based in London, dedicated to helping governments and societies build a sustainably secure, prosperous, and just world. The Environment and Society Centre (ESC) at Chatham House examines how environmental change intersects with global economics, politics, and society. Its work focuses on advancing systemic solutions to address climate change, resource governance, and accelerate circular economy transitions — fostering dialogue and evidence-based strategies that align environmental sustainability with social equity and geopolitical realities. Please let us know what you think of the podcast – and we'd love it if you could leave us a review on iTunes, or wherever you find your podcasts.  Or send us an email… Search for previous episodes….

In February, the Trump administration announced cuts to more than 90% of USAID’s foreign aid contracts and $60 billion in overall assistance around the world. In July, the agency’s remaining programs were brought under the control of the State Department. Thousands of USAID staff and contractors working in the US and around the world have been fired or laid off, including Portlander Leah Petit. A global health professional for nearly 20 years, Petit was a senior program advisor at USAID’s Office of HIV/AIDS when she lost her job in late January. Her projects focused on strengthening local health systems in Africa and Asia to sustain long-term HIV prevention, monitoring and treatment efforts.    In August, Petit embarked on a new career when she launched “Global Development Interrupted,” a podcast she hosts and produces featuring former USAID workers who help dispel misconceptions about the agency’s work overseas and how it has benefited Americans here. Established nearly 65 years ago, USAID has delivered lifesaving humanitarian assistance and medicines, mobilized to halt the spread of deadly diseases like Ebola, expanded access to clean drinking water and sanitation, along with countless other relief and development programs. Petit joins us to share more details about her podcast and what’s at stake when the US reverses its leadership on international aid, including the millions of lives that are expected to be lost with the dismantling of USAID.  

In patients with heart failure, remote hemodynamic monitoring can identify health changes long before symptoms appear, contributing to slower disease progression, improved patient outcomes, and reduced rehospitalizations. Learn more about current and future technology that can support better patient health, and the role of nurses in patient education and monitoring. Guests: Linda Park, PhD, MS, FNP-BC, FAAN, FAHA, FPCNA, and Eryn Bryant, MSN, APRN-CNP, FPCNA.PCNA Heart Failure Tools: https://pcna.net/health-topics/heart-failure/Tele-HF study: https://www.jacc.org/doi/10.1016/j.jchf.2015.07.017 CHAMPION Trial (CMEMs after CRT): Pulmonary Artery Pressure-Guided Management of Patients With Heart Failure and Reduced Ejection Fraction https://www.acc.org/latest-in-cardiology/clinical-trials/2015/12/29/12/44/championJournal of American College of Cardiology paper, Remote Monitoring and Heart Failure Scientific Statement: https://www.jacc.org/doi/10.1016/j.jacc.2023.04.010 European Society of Cardiology consensus statement: https://doi.org/10.1093/eurheartjsupp/suae116BMAD trial: BMAD Trial: Wearable Remote Monitor Reduces Hospital Readmission Risk in HF Patients - American College of Cardiology: https://www.acc.org/Latest-in-Cardiology/Articles/2023/03/01/22/45/mon-830am-bmad-acc-2023 GUIDE-HF trial (CMEMS, Lancet): Haemodynamic-guided management of heart failure (GUIDE-HF): a randomised controlled trial - The Lancet: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)01754-2/abstractESCAPE trial (using RHC / pulm art pressures to guide therapy during ADHF: Evaluation study of congestive heart failure and pulmonary artery catheterization effectiveness: the ESCAPE trial - PubMed: https://pubmed.ncbi.nlm.nih.gov/16204662/MONITOR-HF trial (improved QOL and functional status w/ CMEMs): Remote haemodynamic monitoring of pulmonary artery pressures in patients with chronic heart failure (MONITOR-HF): a randomised clinical trial - The Lancet: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)00923-6/abstract MONITOR-HF: Pulmonary artery pressure monitoring in chronic heart failure: effects across clinically relevant subgroups in the MONITOR-HF trial | European Heart Journal | Oxford Academic: https://academic.oup.com/eurheartj/article/45/32/2954/7668040MONITOR-HF (summary in ACC): Remote Hemodynamic Monitoring of Pulmonary Artery Pressures in Patients With Chronic Heart Failure - American College of Cardiology: https://www.acc.org/Latest-in-Cardiology/Clinical-Trials/2023/07/18/17/21/monitor-hfHeartLogic: HeartLogic Multisensor Algorithm Identifies Patients During Periods of Significantly Increased Risk of Heart Failure Events: https://www.ahajournals.org/doi/10.1161/CIRCHEARTFAILURE.117.004669SCALE-HF-1 Trial (bodyport scale to predict worsening HF trends): Use of a Cardiac Scale to Predict Heart Failure Events: Design of SCALE-HF 1 | Circulation: Heart Failure: https://www.ahajournals.org/doi/10.1161/CIRCHEARTFAILURE.122.010012See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

The verdict on climate change is bleaker than ever before. The remaining carbon budget to limit global warming to 1.5°C is rapidly shrinking – equivalent to just three years of emissions at current rates. What is the scientific framework known as planetary boundaries? What's science telling us about the economic impact of climate change? And how is the ECB addressing climate and nature-related risks? Our host Paul Gordon speaks to Johan Rockström, Director of the Potsdam Institute for Climate Impact Research, and Irene Heemskerk, head of the ECB's climate change centre, to find out why. The views expressed are those of the speakers and not necessarily those of the European Central Bank. Recorded on 8 October 2025 and published on 14 October 2025. In this episode: 01:48 Where do we stand in the fight against climate change? What is science telling us? What could get us back on track? 05:58 Is climate change attracting enough attention? Is it being overshadowed by other challenges, like the war in Ukraine or geopolitical fragmentation? How is climate change connected to the economy? And what level of risk are we facing? 10:30 What are planetary boundaries? What is the planetary boundaries framework? 14:50 The phases of climate change How has global warming evolved over time? Are we heading for disaster? Is the 1.5°C threshold a goal or a limit? 19:15 Why is our economy dependent on climate change? Why do climate insights matter to the work of a central bank? How does the ECB take climate change into account? What risks does climate change pose to our primary mandate, price stability? And is it too late for us to take action? 23:03 What is the “right pace” for transitioning to a carbon-neutral economy? How can we balance the need for rapid change with economic interests ? 26:15 Does every step matter? What's needed for an orderly transition? What progress has been made in recent years, and what decisions could accelerate it further? 31:55 Our guests' hot tips Johan and Irene share their hot tips. Johan's hot tip: The EAT-Lancet Commission on healthy, sustainable, and just food systems (published on 2 October 2025) https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)01201-2/abstract TED Talks by Johan Rockström https://www.youtube.com/watch?v=RgqtrlixYR4 (2010) https://www.youtube.com/watch?v=Rv-tDrv__mc (2018) https://www.youtube.com/watch?v=8Sl28fkrozE (2020) https://www.youtube.com/watch?v=Vl6VhCAeEfQ (2024) Climate change and the ECB https://www.ecb.europa.eu/ecb/climate/html/index.en.html The ECB Podcast: The ECB's climate and nature plan: our path to a greener future https://www.ecb.europa.eu/press/tvservices/podcast/html/ecb.pod240125_episode78.en.html The tipping points of climate change – and where we stand https://www.ted.com/talks/johan_rockstrom_the_tipping_points_of_climate_change_and_where_we_stand?subtitle=en&geo=de ECB Instagram https://www.instagram.com/europeancentralbank/

In this episode Matthew reviews a conversation that Lee Strobel had with Justin Brierley in April 2022. In that discussion Lee tried very hard to make a case for heaven, and Matthew examines the points he makes and revealing why his case is utter bunk. It literally is wishful thinking gone wild.The original you tube video of the conversation is at link 1, it's not long, about 20 minutes. Lee's Case for heaven movie is at link 2. It's longer at almost 2 hours.1) Original conversation between Lee and Justinhttps://www.youtube.com/watch?v=a7Oeh8L-87U2) case for heaven moviehttps://www.youtube.com/watch?v=NbkwdT3Tq403) hyponatraemiahttps://cks.nice.org.uk/topics/hyponatraemia/https://cks.nice.org.uk/topics/hyponatraemia/background-information/complications/4) Being Close to Death can Transform Your Life.https://www.psychologytoday.com/gb/blog/understanding-grief/202411/can-being-close-to-death-transform-your-life?msockid=312d907b5d7169080dc782295cba68f75) Sharon Dirckxhttps://www.churchtimes.co.uk/articles/2023/17-february/features/interviews/interview-sharon-dirckx-christian-apologisthttps://www.solas-cpc.org/book-am-i-just-my-brain-by-sharon-dirckx/6) the Lancethttps://www.thelancet.com/journals/lancet/article/PIIS0140-6736(01)07100-8/abstract7) Failure to Elicit Near-Death Experiences in Induced Cardiac Arresthttps://med.virginia.edu/perceptual-studies/wp-content/uploads/sites/360/2017/01/NDE47.pdf8) the maria storyhttps://www.patheos.com/blogs/danpeterson/2019/07/the-shoe-on-the-ledge.htmlhttps://www.is-there-a-god.info/blog/life/whatever-happened-to-my-tennis-shoean-nde-story/9) Blind Vicky NDEhttps://ndestories.org/vicki-noratuk/10) Psychology today article on apparent evidence for a soulhttps://www.psychologytoday.com/us/blog/biocentrism/201112/does-the-soul-exist-evidence-says-yes11) Pam Reynoldshttps://en.wikipedia.org/wiki/Pam_Reynolds_caseBBC report on the casehttps://www.youtube.com/watch?v=osfIY4B3y1U12) science articleshttps://www.scientificamerican.com/article/peace-of-mind-near-death/https://sciencebasedlife.wordpress.com/2011/09/13/near-death-experiences-science-after-all/13) Howard storm traumatic NDEhttps://thepurposeoflife-nde.com/howard-storm/https://near-death.com/howard-storm/To contact us, email: reasonpress@gmail.comour YouTube: https://www.youtube.com/@reasonpress2901Our Theme Music was written for us by Holly, to support her and to purchase her music use the links below:https://hollykirstensongs.com/https://hollykirsten.bandcamp.com/

Daniel Månsson is a clinical psychologist and co-founder of Flow Neuroscience, a medical device comapny which produces transcranial direct current stimulation (TDCS) headsets for depression. Today we discuss: What may be happening neurologically in certain cases of depressionDifferent research studies that have looked into the effectiveness of TDCS treatment for depressionThe ethical challenges of studying, producing and selling medical devicesHow these devices may complement psychological treatments like psychotherapy Studies mentioned:Transcranial direct current stimulation as an additional treatment to selective serotonin reuptake inhibitors in adults with major depressive disorder in Germany (DepressionDC): a triple-blind, randomised, sham-controlled, multicentre trial - The Lancet - https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)00640-2/abstractHome-based transcranial direct current stimulation treatment for major depressive disorder: a fully remote phase 2 randomized sham-controlled trial | Nature Medicine -  https://www.nature.com/articles/s41591-024-03305-yHome-Use Transcranial Direct Current Stimulation for the Treatment of a Major Depressive Episode: A Randomized Clinical Trial | Depressive Disorders | JAMA Psychiatry | JAMA Network https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2813623Northamptonshire NHS study:https://www.scirp.org/journal/paperinformation?paperid=131358--------------------------------------------------------------------------------------------------------------Interviewed by Dr. Alex Curmi with Dr. Anya Borissova. Dr. Alex is a consultant psychiatrist and a UKCP registered psychotherapist in-training. Dr. Anya is a academic registrar psychiatrist at the South London and Maudsley trust. If you would like to invite Alex to speak at your organisation please email alexcurmitherapy@gmail.com with "Speaking Enquiry" in the subject line.Alex is not currently taking on new psychotherapy clients, if you are interested in working with Alex for focused behaviour change coaching , you can email - alexcurmitherapy@gmail.com with "Coaching" in the subject line.Check out The Thinking Mind Blog on Substack: https://substack.com/home/post/p-174371597Give feedback here - thinkingmindpodcast@gmail.com Follow us here: Twitter @thinkingmindpod Instagram @thinkingmindpodcast

Gavin, Richard, and Jessamy enter the studio once more for a Lancet Voice chat. A new book on Alzheimer's disease causes controversy across the Lancet team, we discuss the new Countdown on Plastics & Health, and a quick look at the problems facing the upcoming UN High Level Meeting on NCDs.You can read the Lancet Countdown on health and plastics here:https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)01447-3/fulltext?dgcid=buzzsprout_tlv_podcast_August_25_lancetSend us your feedback!Read all of our content at https://www.thelancet.com/?dgcid=buzzsprout_tlv_podcast_generic_lancetCheck out all the podcasts from The Lancet Group:https://www.thelancet.com/multimedia/podcasts?dgcid=buzzsprout_tlv_podcast_generic_lancetContinue this conversation on social!Follow us today at...https://thelancet.bsky.social/https://instagram.com/thelancetgrouphttps://facebook.com/thelancetmedicaljournalhttps://linkedIn.com/company/the-lancethttps://youtube.com/thelancettv

Como e quanto a publicidade de bebidas alcoólicas impacta no seu consumo? Que estratégias são utilizadas para fugir das restrições à publicidade? Este episódio é um oferecimento da ACT Promoção da Saúde, organização não governamental que atua na promoção e defesa de políticas de saúde públicas. Conheça mais em https://actbr.org.br/Confira o papo entre o leigo curioso, Ken Fujioka, e o cientista PhD, Altay de Souza.>> OUÇA (60min 25s)*Naruhodo! é o podcast pra quem tem fome de aprender. Ciência, senso comum, curiosidades, desafios e muito mais. Com o leigo curioso, Ken Fujioka, e o cientista PhD, Altay de Souza.Edição: Reginaldo Cursino.http://naruhodo.b9.com.br*APOIO: INSIDERIlustríssima ouvinte, ilustríssimo ouvinte do Naruhodo, neste momento INSIDER, vou dar uma opinião polêmica.Preparado? Então, toma essa: calças jeans são desconfortáveis.Eu usei calças jeans por anos a fio. Mesmo sentindo desconforto. Aquele tecido grosso, pouco maleável e que retém muito calor.Porque eu sempre achei calça social muito coxinha - não combinava comigo.Mas os meus problemas acabaram. Eu conheci a Calça FutureForm da INSIDER.Ela é o meio-termo perfeito: visual elegante, conforto real, com bolso funcional e tecido que não precisa passar. Tem conforto de moletom e cara de calça de sair. Vai do trabalho ao rolê sem trocar de roupa.É ou não é a calça ideal?Então fica aqui meu convite: experimente INSIDER e aproveite o desconto de 15% para ouvintes do NARUHODO.Para isso, o jeito mais fácil é usar o endereço: creators.insiderstore.com.br/NARUHODOOu clicar no link da descrição deste episódio: o cupom NARUHODO será aplicado automaticamente no carrinho.INSIDER: inteligência em cada escolha. #InsiderStore*APOIO: ACT PROMOÇÃO DA SAÚDEA ACT Promoção da Saúde é uma organização não governamental que atua na promoção e defesa de políticas de saúde pública, especialmente nas áreas de controle do tabagismo, alimentação saudável, controle do álcool e atividade física.Esse trabalho é realizado por meio de ações de advocacy, que incluem incidência política, comunicação, mobilização, formação de redes e pesquisa, entre outras.Conheça mais em https://actbr.org.br/*REFERÊNCIASRegulação da publicidade para Bebidas Alcoólicashttps://www12.senado.leg.br/publicacoes/estudos-legislativos/tipos-de-estudos/textos-para-discussao/td-20-regulacao-da-publicidade-das-bebidas-alcoolicasAlcohol Consumption and the Preventive Paradoxhttps://pubmed.ncbi.nlm.nih.gov/3461846/Estimação dos custos diretos e indiretos atribuíveis ao consumo de álcool no Brasil https://www.fiocruzbrasilia.fiocruz.br/wp-content/uploads/2024/11/Relatorio-Tecnico.pdfGlobal Burden of Diseasehttps://www.thelancet.com/gbdDigital platforms and leading beer, wine, and spirits brands unite to enhance age assurance for online alcohol marketinghttps://www.iard.org/getmedia/49ee2600-6073-48c6-892c-155c31241816/06052024-Digital-Statement-of-Intent-June-2024.pdf?utm_source=chatgpt.comIndependent study shows low ad exposure to alcohol ads onlinehttps://wfanet.org/knowledge/item/2022/03/29/Independent-study-shows-low-ad-exposure-to-alcohol-ads-onlineWhere should the safe limits of alcohol consumption stand in light of liver enzyme abnormalities in alcohol consumers?https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0188574Trade Me pulls listings for influencer Logan Paul's Prime energy drinkhttps://www.stuff.co.nz/business/132286965/trade-me-pulls-listings-for-influencer-logan-pauls-prime-energy-drinkThe Global Burden of Disease Study at 30 yearshttps://www.nature.com/articles/s41591-022-01990-1No safe level of alcohol consumption – Implications for global healthhttps://www.journal-of-hepatology.eu/article/S0168-8278(18)32640-0/abstractDo not leave any ambiguity: Alcohol in any amount is harmfulhttps://www.sciencedirect.com/science/article/pii/S0168827824027417Is there a safe limit for consumption of alcohol?https://www.sciencedirect.com/science/article/pii/S016882782402645XPopulation-level risks of alcohol consumption by amount, geography, age, sex, and year: a systematic analysis for the Global Burden of Disease Study 2020https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(22)00847-9/fulltextRevising the preventive paradox: the Swiss casehttps://onlinelibrary.wiley.com/doi/abs/10.1046/j.1360-0443.2001.96227311.xThe distribution of alcohol consumption and the prevention paradox in Brazilhttps://onlinelibrary.wiley.com/doi/full/10.1111/j.1360-0443.2011.03567.xRedução de 20% no consumo de álcool pode salvar uma vida por hora no Brasilhttps://www.vitalstrategies.org/reducao-de-20-no-consumo-de-alcool-pode-salvar-uma-vida-por-hora-no-brasilNaruhodo #371 - Qual o impacto do alcoolismo nos dias de hoje? - Parte 1 de 2https://www.youtube.com/watch?v=JAIjJ6E8ZHkNaruhodo #372 - Qual o impacto do alcoolismo nos dias de hoje? - Parte 2 de 2https://www.youtube.com/watch?v=ZRwC2GQevIoNaruhodo #134 - Bebida alcoólica aumenta a longevidade mais que exercício físico?https://www.youtube.com/watch?v=r0mvpl1hLgcNaruhodo #108 - Bebida alcoólica ajuda a falar melhor uma língua estrangeira? https://www.youtube.com/watch?v=GPNIUjgqHPoNaruhodo #31 - Misturar bebidas alcoólicas piora a ressaca?https://www.youtube.com/watch?v=tA3OJmEjXMYNaruhodo #339 - Por que as coisas parecem girar quando estamos bêbados? https://www.youtube.com/watch?v=YmK1Yq0mwW8Naruhodo #419 - Maconha faz mal? - Parte 1 de 2 https://www.youtube.com/watch?v=cvLTh2bKPiQNaruhodo #420 - Maconha faz mal? - Parte 2 de 2https://www.youtube.com/watch?v=F7wVcGvpoGANaruhodo #207 - Vape e cigarro eletrônico são seguros?https://www.youtube.com/watch?v=Raa9CUrIFbsNaruhodo #432 - O uso de cigarros eletrônicos é um problema de saúde pública?https://www.youtube.com/watch?v=XCiHLKVWDVQNaruhodo #328 - Existem "gatilhos mentais"?https://www.youtube.com/watch?v=fxBQJlin8Z4Naruhodo #390 - Fazer compras para si mesma melhora o humor?https://www.youtube.com/watch?v=k98xTfw9gTsNaruhodo #155 - Tomar decisões cansa o nosso cérebro?https://www.youtube.com/watch?v=tqEfVCT4dGoNaruhodo #407 - Existe razão sem emoção?https://www.youtube.com/watch?v=qUxluRrHV3ENaruhodo #445 - Por que temos mais medo de tubarões que de vacas? https://www.youtube.com/watch?v=QMR0x1Qu2BcNaruhodo #291 - Por que preferimos certas marcas a outras? https://www.youtube.com/watch?v=ho78PbF8LJ0Naruhodo #208 - Qual o efeito da publicidade sobre as crianças? - Parte 1 de 2https://www.youtube.com/watch?v=E2s-p8D0MTcNaruhodo #209 - Qual o efeito da publicidade sobre as crianças? - Parte 2 de 2https://www.youtube.com/watch?v=gS3Sc21lEZUNaruhodo #299 - Como buscar fontes confiáveis sobre coisas que nos interessam? https://www.youtube.com/watch?v=_uQCEsN8YOwNaruhodo Entrevista #45: Malu Formigonihttps://www.youtube.com/watch?v=muWIFxLU3xc*APOIE O NARUHODO!O Altay e eu temos duas mensagens pra você.A primeira é: muito, muito obrigado pela sua audiência. Sem ela, o Naruhodo sequer teria sentido de existir. Você nos ajuda demais não só quando ouve, mas também quando espalha episódios para familiares, amigos - e, por que não?, inimigos.A segunda mensagem é: existe uma outra forma de apoiar o Naruhodo, a ciência e o pensamento científico - apoiando financeiramente o nosso projeto de podcast semanal independente, que só descansa no recesso do fim de ano.Manter o Naruhodo tem custos e despesas: servidores, domínio, pesquisa, produção, edição, atendimento, tempo... Enfim, muitas coisas para cobrir - e, algumas delas, em dólar.A gente sabe que nem todo mundo pode apoiar financeiramente. E tá tudo bem. Tente mandar um episódio para alguém que você conhece e acha que vai gostar.A gente sabe que alguns podem, mas não mensalmente. E tá tudo bem também. Você pode apoiar quando puder e cancelar quando quiser. O apoio mínimo é de 15 reais e pode ser feito pela plataforma ORELO ou pela plataforma APOIA-SE. Para quem está fora do Brasil, temos até a plataforma PATREON.É isso, gente. Estamos enfrentando um momento importante e você pode ajudar a combater o negacionismo e manter a chama da ciência acesa. Então, fica aqui o nosso convite: apóie o Naruhodo como puder.bit.ly/naruhodo-no-orelo

Dr. Dan Ackerman talks with Dr. Urs Fischer about the optimal timing of anticoagulation after ischemic stroke in patients with atrial fibrillation.  show reference: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)00439-8/fulltext  

Obiiiiiiish! This week Madison is discussing some infamous cases of people who died on stage! Next, Spencer is discussing the insane true story of skin hunters! We've got an obituary for a diva who got absolutely dragged to filth, one for a man that kept it real and we've got some dumb.ass.criminallllls! Watch us on YouTube: Youtube.com/@obitchuarypodcast Buy our book: prh.com/obitchuaryGet your Merch: wonderyshop.com/obitchuaryCome see us live on tour: obitchuarypodcast.comJoin our Patreon: Patreon.com/cultliterNew episodes come out every Thursday for free, with 1-week early access for Wondery+ subscribers.Follow along online: @obitchuarypod on Twitter & Instagram @obitchuarypodcast on TikTokCheck out Spencer's other podcast Cult Liter wherever you're listening!Write to us: obitpod@gmail.comSpencer Henry & Madison ReyesPO Box 18149 Long Beach, CA 90807Sources:https://fox4kc.com/news/family-stunned-after-desecration-of-love-ones-grave-at-kansas-city-cemetery/https://faroutmagazine.co.uk/tragic-on-stage-death-tiny-tim/https://scholar.lib.vt.edu/VA-news/ROA-Times/issues/1996/rt9612/961202/12020133.htmhttps://allthatsinteresting.com/harry-einsteinhttps://www.historic-uk.com/CultureUK/The-Great-Lafayette/https://thelittlehouseofhorrors.com/the-great-lafayette/https://www.edinburghnews.scotsman.com/news/people/the-great-lafayette-the-world-famous-magician-who-wanted-to-be-buried-in-edinburgh-so-he-could-stay-with-his-dog-4042021https://en.wikipedia.org/wiki/Sigmund_Neubergerhttps://en.wikipedia.org/wiki/Dick_Shawnhttps://www.latimes.com/archives/la-xpm-1987-04-18-me-1079-story.htmlhttps://www.newsbreak.com/herbie-j-pilato-1590342/3967376321297-38-years-ago-comedian-actor-dick-shawn-dropped-dead-on-stage-everyone-thought-it-was-a-jokehttps://www.newspapers.com/image/480360423/?match=1&terms=%22florence%20foster%20jenkins%22https://www.newspapers.com/image/1082706847/?article=b15e0d42-5e1c-49b7-bd00-6dd72cba845c&terms=%22florence%20foster%20jenkins%22https://www.newspapers.com/image/1044689316/?match=1&terms=%22magician%20arrested%22https://nypost.com/2025/07/07/us-news/florida-man-hijacks-key-west-sightseeing-train-for-meth-fueled-joyride-on-birthday/https://lodz.wyborcza.pl/lodz/7,35136,22469386,lowcy-skor.html?_gl=1*1xvuyv2*_gcl_au*MzE0MTM5MzI0LjE3NTIxNzkzOTQ.*_ga*MTkzOTYyODYwMy4xNzUyMTc5Mzkx*_ga_6R71ZMJ3KN*czE3NTIxNzkzOTEkbzEkZzEkdDE3NTIxODAzMzQkajU1JGwwJGgwhttps://www.thelancet.com/journals/lancet/article/PIIS0140-6736(07)60254-2/fulltexthttps://en.m.wikipedia.org/wiki/Skin_Hunters#cite_ref-3See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

After a debilitating injury left Dr. Josh Axe bedridden for a year, he  healed 100% using stem cell therapy. In this episode, Dr. Axe shares how you can reverse chronic pain, autoimmune disease, and even aging– naturally or with advanced regenerative treatments. What You'll Learn: What stem cells are & how they heal the body Dr. Axe's personal healing story with advanced therapy Top foods & supplements to boost stem cell production Why the best treatments are banned in the U.S. Where to get the world's most effective therapy Ready to heal, regenerate, and feel younger? Tune in and learn how to activate your body's natural healing power today. #stemcells #regenerativemedicine #draxe ------  Want more of The Dr. Josh Axe Show? Subscribe to the YouTube channel. Follow Dr. Josh Axe Instagram Twitter Facebook TikTok Website ------  Staying healthy in today's world is an upstream battle. Subscribe to Wellness Weekly, your 5-minute dose of sound health advice to help you grow physically, mentally, and spiritually. Every Wednesday, you'll get:  Holistic health news & life-hacks from a biblical world view Powerful free resources including classes, Q&As, and guides from Dr. Axe The latest episodes of The Dr. Josh Axe Show Submit your questions via voice memo to be featured on the show → speakpipe.com/drjoshaxe  ------  Links:  https://medlineplus.gov/stemcells.html https://www.unmc.edu/stemcells/stemcells/ https://kffhealthnews.org/news/superstar-athletes-popularize-unproven-stem-cell-procedures/ https://projects.sfchronicle.com/2018/stem-cells/about-stem-cells/ https://my.clevelandclinic.org/health/body/24892-stem-cells https://www.urmc.rochester.edu/encyclopedia/content https://www.cellmedicine.com/famous-stem-cell-cases-celebrities-athletes-who-have-received-therapy/ https://stemcells.nih.gov/info/basics/stc-basics https://www.bioxcellerator.com/blog/list-of-50-athletes-that-have-received-stem-cell-therapy-to-recover https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-016-0998-2 https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(16)30513-X/abstract https://pmc.ncbi.nlm.nih.gov/articles/PMC8280064/ https://pubmed.ncbi.nlm.nih.gov/23172272/ https://journals.lww.com/international-journal-of-surgery/fulltext/2024/12000/safety_and_efficacy_of_stem_cell_therapy_for.9.aspx https://pmc.ncbi.nlm.nih.gov/articles/PMC7459379/ https://pmc.ncbi.nlm.nih.gov/articles/PMC9652517/ https://bmtinfonet.org/transplant-article/diseases-treated-transplant ------  Ads:  Get your free wealth protection guide from Preserve Gold. Visit www.preservegold.com/axe or text AXE to 50505 to claim your free guide, and you could receive up to $15,000 in free gold or silver with a qualified purchase or account rollover. Don't wait – claim your special offers today!  Unlock targeted biomarker testing—hormones, thyroid, metabolism—plus a 1-hour consult with a Senior Health Advisor. Spots are limited, grab yours now at MyBloodwork.com. Learn more about your ad choices. Visit megaphone.fm/adchoices

Today we discuss sex and vaccines, reality and renegades. First: men can no longer compete in women's sports—from Trump's Executive Order, to the NCAA's response, to William “Lia” Thomas having his records rescinded at Penn, reality is prevailing. Other evidence includes the UK Supreme Court declaring that “man” and “woman” refer to biological reality; and the U.S. Supreme Court writing an opinion that forcing LGBTQ+ books on children in public elementary schools is unconstitutional. Men cannot magically turn into women, nor boys into girls, no matter what they believe or are told. Then: from the ACIP (Advisory Committee on Immunization Practices) to Vinay Prasad's latest presentation at the FDA: the federal government is being populated by a combination of true renegades and middle ground scramblers who are dressed like renegades. A good toolkit for understanding how to make sense of the claims being made is necessary, and we all should be rooting for the renegades to win.*****Our sponsors:CrowdHealth: Pay for healthcare with crowdfunding instead of insurance. It's way better. Use code DarkHorse at JoinCrowdHealth.com to get 1st 3 months for $99/month.ARMRA Colostrum is an ancient bioactive whole food that can strengthen your immune system. Go to http://www.tryarmra.com/DARKHORSE to get 15% off your first order.Helix: Excellent, sleep-enhancing, American-made mattresses. Go to www.HelixSleep.com/DarkHorse for 27% Off - an offer exclusive for listeners of DarkHorse!*****Join us on Locals! Get access to our Discord server, exclusive live streams, live chats for all streams, and early access to many podcasts: https://darkhorse.locals.comHeather's newsletter, Natural Selections (subscribe to get free weekly essays in your inbox): https://naturalselections.substack.comOur book, A Hunter-Gatherer's Guide to the 21st Century, is available everywhere books are sold, including from Amazon: https://amzn.to/3AGANGg (commission earned)Check out our store! Epic tabby, digital book burning, saddle up the dire wolves, and more: https://darkhorsestore.org*****Mentioned in this episode:Trump's EO: https://www.whitehouse.gov/presidential-actions/2025/02/keeping-men-out-of-womens-sports/Paula Scanlan speaks about men in women's sports:https://x.com/xx_xyathletics/status/1940381615131332719U.K. Supreme Court: https://www.supremecourt.uk/cases/uksc-2024-0042The Lancet – sex isn't binary! https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)00834-7/fulltextU.S. Supreme Court – Mahmoud vs Taylor: https://www.supremecourt.gov/opinions/24pdf/24-297_4f14.pdfWilliam Thomas in the record books: https://www.outkick.com/sports/lia-thomas-upenn-womens-swimming-record-books-updated-acknowledges-transgender-swimmer-noteRFK Jr on Tucker: https://www.youtube.com/watch?v=w_fzlwxJZAAACIP committee with Robert Malone and Retsef Levi: https://x.com/janjekielek/status/1939482343313453423Prasad on myocarditis: https://x.com/US_FDA/status/1940111214497210425Prasad makes full professor: https://x.com/bretweinstein/status/1554849287300792320Earlier clips of ZDogg and Prasad and Makary: https://x.com/alexandrosm/status/1574530850565558272Support the show

In part two of this three-part series, Dr. Andy Southerland and Dr. Seemant Chaturvedi discuss the OPTIMISTmain Trial, which was presented at the 2025 European Stroke Organization Conference. Show reference:  https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)00549-5/abstract 

Listen as we discuss the highly-awaited ESOPEC trial, which examines treatment regimens for esophageal and EGJ adenocarcinoma. Wildly impress your thoracic attendings or peers with your nuanced knowledge! FLOT who? You'll know. Pull out the paper and listen along! Learning Objectives: -Discuss the patient population in the ESOPEC trial -Discuss the main differences between the ESOPEC trial and the CROSS trial -Describe the main drawbacks between FLOT and the CROSS regimen. Hosts: Chloe Hanson MD, Brian Louie MD, and Peter White MD   Referenced Material https://www.nejm.org/doi/full/10.1056/NEJMoa2409408 Hoeppner J, Brunner T, Schmoor C, Bronsert P, Kulemann B, Claus R, Utzolino S, Izbicki JR, Gockel I, Gerdes B, Ghadimi M, Reichert B, Lock JF, Bruns C, Reitsamer E, Schmeding M, Benedix F, Keck T, Folprecht G, Thuss-Patience P, Neumann UP, Pascher A, Imhof D, Daum S, Strieder T, Krautz C, Zimmermann S, Werner J, Mahlberg R, Illerhaus G, Grimminger P, Lordick F. Perioperative Chemotherapy or Preoperative Chemoradiotherapy in Esophageal Cancer. N Engl J Med. 2025 Jan 23;392(4):323-335. doi: 10.1056/NEJMoa2409408. PMID: 39842010. https://www.nejm.org/doi/full/10.1056/NEJMoa1112088 van Hagen P, Hulshof MC, van Lanschot JJ, Steyerberg EW, van Berge Henegouwen MI, Wijnhoven BP, Richel DJ, Nieuwenhuijzen GA, Hospers GA, Bonenkamp JJ, Cuesta MA, Blaisse RJ, Busch OR, ten Kate FJ, Creemers GJ, Punt CJ, Plukker JT, Verheul HM, Spillenaar Bilgen EJ, van Dekken H, van der Sangen MJ, Rozema T, Biermann K, Beukema JC, Piet AH, van Rij CM, Reinders JG, Tilanus HW, van der Gaast A; CROSS Group. Preoperative chemoradiotherapy for esophageal or junctional cancer. N Engl J Med. 2012 May 31;366(22):2074-84. doi: 10.1056/NEJMoa1112088. PMID: 22646630. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(18)32557-1/abstract Al-Batran SE, Homann N, Pauligk C, Goetze TO, Meiler J, Kasper S, Kopp HG, Mayer F, Haag GM, Luley K, Lindig U, Schmiegel W, Pohl M, Stoehlmacher J, Folprecht G, Probst S, Prasnikar N, Fischbach W, Mahlberg R, Trojan J, Koenigsmann M, Martens UM, Thuss-Patience P, Egger M, Block A, Heinemann V, Illerhaus G, Moehler M, Schenk M, Kullmann F, Behringer DM, Heike M, Pink D, Teschendorf C, Löhr C, Bernhard H, Schuch G, Rethwisch V, von Weikersthal LF, Hartmann JT, Kneba M, Daum S, Schulmann K, Weniger J, Belle S, Gaiser T, Oduncu FS, Güntner M, Hozaeel W, Reichart A, Jäger E, Kraus T, Mönig S, Bechstein WO, Schuler M, Schmalenberg H, Hofheinz RD; FLOT4-AIO Investigators. Perioperative chemotherapy with fluorouracil plus leucovorin, oxaliplatin, and docetaxel versus fluorouracil or capecitabine plus cisplatin and epirubicin for locally advanced, resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4): a randomised, phase 2/3 trial. Lancet. 2019 May 11;393(10184):1948-1957. doi: 10.1016/S0140-6736(18)32557-1. Epub 2019 Apr 11. PMID: 30982686. ***Fellowship Application Link: https://forms.gle/PQgAvGjHrYUqAqTJ9 Please visit https://behindtheknife.org to access other high-yield surgical education podcasts, videos and more. If you liked this episode, check out our recent episodes here: https://app.behindtheknife.org/listen

We're thrilled to be joined for a special return to the topic of Cancer by our own magnificent editorial assistant, Deboki Chakravarti! We cover a ton in this beefy episode, so grab a snack, get comfy, and prepare to dive deep on a topic that's well worth the revisit. SciShow Tangents is on YouTube! Go to www.youtube.com/scishowtangents to check out this episode with the added bonus of seeing our faces! Head to www.patreon.com/SciShowTangents to find out how you can help support SciShow Tangents, and see all the cool perks you'll get in return, like bonus episodes and a monthly newsletter! A big thank you to Patreon subscriber Garth Riley for helping to make the show possible!And go to https://store.dftba.com/collections/scishow-tangents to buy some great Tangents merch!Follow us on Twitter @SciShowTangents, where we'll tweet out topics for upcoming episodes and you can ask the science couch questions! While you're at it, check out the Tangents crew on Twitter: Ceri: @ceriley Sam: @im_sam_schultz Hank: @hankgreen[Truth or Fail]Water-logged diaper scanshttps://www.nist.gov/pml/about-pml/pml-working-you/pml-working-you-archives/fighting-cancer-diapershttps://www.nist.gov/news-events/news/2017/11/how-disposable-diapers-can-improve-measurements-tumor-growthToothbrush cancer camerahttps://www.forbes.com/sites/rachelsandler/2022/09/22/why-billionaire-eric-schmidt-is-backing-a-high-school-senior-making-a-cancer-detecting-toothbrush-and-other-brilliant-teens/https://www.mayoclinic.org/medical-professionals/obstetrics-gynecology/news/a-substantial-step-toward-earlier-endometrial-cancer-detection/mac-20560620Cancer-cell kleenexhttps://www.statnews.com/2017/09/06/masspec-pen-cancer/[This or That: Researcher, Patient, or Both]Round 1 - Sister Mary Joseph Nodulehttps://www.sciencedirect.com/science/article/pii/S2468294222000089#sec0006https://link.springer.com/article/10.1007/s00261-016-1031-1https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(18)31864-6/abstractRound 2 - Trousseau sign of malignancyhttps://www.sciencedirect.com/science/article/pii/S2468294222000089#sec0002https://pmc.ncbi.nlm.nih.gov/articles/PMC1022062/Round 3 - AOH1996https://www.alexslemonade.org/blog/chance-meeting-leads-promising-cancer-treatmenthttps://pmc.ncbi.nlm.nih.gov/articles/PMC10592352/https://clinicaltrials.gov/study/NCT05227326Round 4 - Papanicolaou (Pap) testhttps://acsjournals.onlinelibrary.wiley.com/doi/10.1002/cncy.22734https://www.sciencedirect.com/science/article/abs/pii/S2213294514002178[Ask the Science Couch]Proposition 65 in the state of California & carcinogens in studieshttps://oehha.ca.gov/proposition-65/about-proposition-65https://oehha.ca.gov/proposition-65/proposition-65-listhttps://oehha.ca.gov/proposition-65/how-chemicals-are-added-proposition-65-listhttps://pmc.ncbi.nlm.nih.gov/articles/PMC6349368/https://link.springer.com/article/10.1007/s10311-023-01668-1https://www.cancer.gov/about-cancer/causes-prevention/risk/substances/wood-dust Patreon bonus: Treatments for different cancers and why there's no singular curehttps://www.cancer.gov/about-cancer/treatment/typeshttps://www.aacr.org/patients-caregivers/about-cancer/what-is-cancer/https://www.cancercenter.com/community/blog/2023/10/cancer-is-not-one-diseasehttps://medlineplus.gov/cancer.html[Butt One More Thing]A trained dog could sniff out colorectal cancer in poop sampleshttps://gut.bmj.com/content/60/6/814https://www.cshl.edu/the-doctor-will-sniff-you-now/