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TWiV reviews new CBER chief at FDA, ending of Gates Foundation in 2045, gain of function executive order, origins of bat viruses ancestral to SARS-CoV and SARS-CoV-2, and single dose Sudan virus replicon vaccine protects guinea pigs from disease. Hosts: Vincent Racaniello, Alan Dove, and Rich Condit Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV Prasad replaces Marks at FDA (US News) Gates Foundation ends 2025 (Gates Foundation) Gain of function Executive Order (White House) DURC policy (HHS) Origins of bat viruses ancestral to SARS-CoV and SARS-CoV-2 (Cell) Sudan virus replicon vaccine (Nat Comm) Letters read on TWiV 1217 Timestamps by Jolene Ramsey. Thanks! Weekly Picks Rich – Andor Season 2 Alan – Sequencing Mendel's pea plant traits, and a good Science news article on the work Vincent – 2023 summer warmth unparalleled over the past 2,000 years Listener Pick Brian – Virology Capabilities Test (VCT): A Multimodal Virology Q&A Benchmark Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv Content in this podcast should not be construed as medical advice.
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SPONSORED BY NEBCOOur Sponsors:* Check out Hims: https://hims.com/EARLYBREAKAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy
SHOW SPONSORED BY NEBCOOur Sponsors:* Check out Hims: https://hims.com/EARLYBREAKAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy
Nebraska Athletic Director Troy Dannen is joining the CFP Playoff Selection committee.Tom Osborne was involved in the first ever CFP committee in 2014...Mike Riley(2024,2025), Will Shields (2021-2024), Mark Dantonio (2025)Sponsored by NEBCOOur Sponsors:* Check out Hims: https://hims.com/EARLYBREAKAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy
Good Luck to everyone running in the marathon/half marathon on Sunday in Lincoln!SHOW SPONSORED BY NEBCOOur Sponsors:* Check out Hims: https://hims.com/EARLYBREAKAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy
-Sip's NBA corner….who played last night and who's up tonight?Show sponsored by NEBCOAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy
-Sip's NBA Corner…4 games last night…what's on tap tonight? And Heavenly Waffles today 10a-1pm at the station!Show sponsored by NEBCOOur Sponsors:* Check out Hims: https://hims.com/EARLYBREAKAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy
-It's time for Sip's NBA Corner….what happened last night and what's ahead today?Show sponsored by NEBCOOur Sponsors:* Check out Hims: https://hims.com/EARLYBREAKAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy
-How will Jake celebrate his birthday today?Show sponsored by NEBCOOur Sponsors:* Check out Hims: https://hims.com/EARLYBREAKAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy
-Final thoughts on tomorrow's Spring Game and Sip's complete avoidance of the Media Challenge…Show sponsored by NEBCOOur Sponsors:* Check out Hims: https://hims.com/EARLYBREAKAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy
-Final thoughts on tonight's NFL Draft…overall interest of The Stool and the listenersShow sponsored by NEBCOOur Sponsors:* Check out Hims: https://hims.com/EARLYBREAKAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy
-Sip's NBA Corner to close the show…and can the guys commit to watching any part of an NHL Playoff game?Show sponsored by NEBCOOur Sponsors:* Check out Hims: https://hims.com/EARLYBREAKAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy
-What NBA games is Sip watching tonight? Did Jake and Bill respect his “don't text me” request last night at 6:30pm?Show sponsored by NEBCOOur Sponsors:* Check out Hims: https://hims.com/EARLYBREAKAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy
-An MLB team put up 24 runs yesterday and another team stole 9 bases…what in the world is going on in baseballShow sponsored by NEBCOOur Sponsors:* Check out Hims: https://hims.com/EARLYBREAKAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy
-Final look at transfer portal updates and what's on the docket this weekend for The Stool and in sports…Show sponsored by NEBCOOur Sponsors:* Check out Hims: https://hims.com/EARLYBREAKAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy
-How do you celebrate a one-year-old's birthday? Asking for a friend….AKA young ScotlynShow sponsored by NEBCOOur Sponsors:* Check out Hims: https://hims.com/EARLYBREAKAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy
-Update from yesterday's NBA viewing for Sip…did the Magic get it done? And what's on tap tonight in the playoffs..?Show sponsored by NEBCOOur Sponsors:* Check out Hims: https://hims.com/EARLYBREAKAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy
-Sip lets us know who is speaking today at Husker practice availability and what he's curious about…Show sponsored by NEBCOOur Sponsors:* Check out Hims: https://hims.com/EARLYBREAKAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy
-Final thoughts on an epic Masters tournament as the major season gets off to an awesome start…Show sponsored by NEBCOOur Sponsors:* Check out Hims: https://hims.com/EARLYBREAKAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy
-Day 1 of The Masters is complete and we're on to round 2 today…what's the storyline of Friday at Augusta?Show sponsored by NEBCOOur Sponsors:* Check out Hims: https://hims.com/EARLYBREAKAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy
-It's Day 1 of The Masters…how will Jake stay focused on any sort of work today?Show sponsored by NEBCOOur Sponsors:* Check out Hims: https://hims.com/EARLYBREAKAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy
-We don't talk NBA often on this show…but a big firing yesterday in the NBA shocked most people who follow it…Show sponsored by NEBCOOur Sponsors:* Check out Hims: https://hims.com/EARLYBREAKAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy
How to Break the Spillover Habit - Mike CohnFor the past two weeks, I've been writing about the problem of habitual spillover—when a team routinely rolls over unfinished work from sprint to sprint.So far, we've talked about why spillover happens, and why it's a problem, plus I've given steps to start a reduction in your team's spillovers.This week, I want to share two ways to break your team's rollover habit. Sometimes teams miss their goals. That's OK. Sometimes teams miss when they aim high and fall a little short. Don't try to fix those teams—celebrate their effort.Other times teams miss because they just hit a run of bad luck for a handful of sprints. Again, no need to intervene there. (Next week, I'll share what to do with the unfinished work that results from either of these first two scenarios.)Most often, though, teams miss because they are overly optimistic about what they can achieve. They plan each sprint to be a best-case scenario.If you think that could be your team, in your next sprint planning meetings try asking questions like these: What could go wrong that could cause the team to miss its goal?What has to go right to achieve this goal? These questions can help a team see any risky assumptions they're making about how easy the planned work will be. As most of us who made New Year's resolutions at the beginning of 2025 have re-discovered by now, old habits die hard. Sometimes you have to take drastic action to realize lasting results, and to succeed with agile.Curb Their Enthusiasm Drastically Under-commitIf these kinds of questions don't help the team make more realistic guesses about what they can accomplish, you might have to resort to drastically reducing what the team commits to achieving.At the next sprint planning, encourage your team to truly under-commit. I'm not talking about cutting the sprint goal by some small amount, like 10–20%. I'm saying you limit team members to committing to only 50% of what they believe they can accomplish.The team may push back on this. They are used to filling up their sprint and will be optimistic that they can get a lot more done than the items they've chosen. Don't give in.When team members push back, remind them that if they run out of work to do, they can always bring more in. But hold firm that no work will come in until the sprint goal is achieved and all the work planned into the sprint is complete.(You'll likely need to have a talk with the product owner prior to sprint planning so they too can be prepared to hear that the team is bringing only a few items into the sprint.)The goal in under-committing is to let the team feel what it's like to add work into a sprint rather than always needing to drop work.After they feel this, they'll likely want to feel it again.Encourage them to plan a bit more work into the next few sprints until they get close to missing their goals and rolling over again. Incorporate the enthusiasm-curbing questions as needed.How to connect with AgileDad:- [website] https://www.agiledad.com/- [instagram] https://www.instagram.com/agile_coach/- [facebook] https://www.facebook.com/RealAgileDad/- [Linkedin] https://www.linkedin.com/in/leehenson/
-Final thoughts on last night's national championship and how active does the portal news get for Nebrasketball this week?Show sponsored by NEBCOOur Sponsors:* Check out Hims: https://hims.com/EARLYBREAKAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy
Show sponsored by NEBCOOur Sponsors:* Check out Hims: https://hims.com/EARLYBREAKAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy
-Final thoughts on tomorrow's Final Four games and Nebrasketball in their own version of a Final Four at The Crown…Show sponsored by NEBCOOur Sponsors:* Check out Hims: https://hims.com/EARLYBREAKAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy
-Could you imagine Nebraska athletics without having to pay for concessions? What an incredible disaster that would beShow sponsored by NEBCOOur Sponsors:* Check out Hims: https://hims.com/EARLYBREAKAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy
नमस्ते। इस हफ़्ते पुलियाबाज़ी पर प्रणय ने एक मज़ेदार अवलोकन किया। प्रणय को लगता है कि आज की दुनिया ऐसी लगती है मानो कोई प्रियदर्शन फिल्म का क्लाइमेक्स चल रहा हो। कहीं भी, कभी भी, कुछ भी हो सकता है। ऐसे उलट पुलट के दौर में पुलियाबाज़ी पर इसका विश्लेषण तो बनता है। क्या होती है विश्व व्यवस्था? बदलती व्यवस्था के साथ क्या देशों के भाग्य भी बदलेंगे? और बदलेंगे तो कैसे? इन सब बातों पर आज की पुलियाबाज़ी। सुनिए और सुनाइए।We discuss:* The changing World Order* What defines the World Order?* Is the US losing legitimacy?* Spillover of domestic politics* China is also losing its edge* Russia and Europe* The Opportunity for India* Kya Apna Time Aayega?Also, please note that Puliyabaazi is now available on Youtube with video.Read more:[Article] India Policy Watch: Six India-China Comparisons by Pranay Kotasthane[Article] Global Policy Watch #1: Churning of the Land and the Oceans by Pranay Kotasthane[Article] Ingredients of a New World Order by Pranay KotasthaneThanks for listening to this पुलियाबाज़ी Puliyabaazi! If you like our work, please share it with your friends, family and colleagues.Related Puliyabaazi:एक नयी विश्व व्यवस्था के लिए भारत कैसे तैयारी करे? The New World Order and India.भारत का विश्वशास्त्र। India's Foreign Policy in a New World Order ft. Dhruva JaishankarIf you have any questions for the guest or feedback for us, please comment here or write to us at puliyabaazi@gmail.com. If you like our work, please subscribe and share this Puliyabaazi with your friends, family and colleagues.Website: https://puliyabaazi.inHosts: @saurabhchandra @pranaykotas @thescribblebeeTwitter: @puliyabaaziInstagram: https://www.instagram.com/puliyabaazi/Subscribe & listen to the podcast on iTunes, Google Podcasts, Castbox, AudioBoom, YouTube, Spotify or any other podcast app. This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit www.puliyabaazi.in
-Final thoughts on Nebrasketball/Georgetown tonight in The Crown…will the Stool stay up and watch the whole game?Show sponsored by NEBCOOur Sponsors:* Check out Hims: https://hims.com/EARLYBREAKAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy
-Final thoughts on The Crown and what's ahead for Nebrasketball….Show sponsored by NEBCOOur Sponsors:* Check out Hims: https://hims.com/EARLYBREAKAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy
-Final thoughts on Nebraska/Arizona State tonight in The Crown in Vegas…Show sponsored by NEBCOAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy
-Final look ahead to tonight's Sweet 16 games and any more thoughts on last night's games…Show sponsored by NEBCOOur Sponsors:* Check out Hims: https://hims.com/EARLYBREAKAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy
-Which of the 4 Sweet 16 games tonight is most intriguing and which is least intriguing?Show sponsored by NEBCOOur Sponsors:* Check out Hims: https://hims.com/EARLYBREAKAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy
-Final thoughts on yesterday's Pro Day and any other Matt Rhule/player comments we missed from yesterday…Show sponsored by NEBCOOur Sponsors:* Check out Hims: https://hims.com/EARLYBREAKAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy
-Ty Robinson is moving up draft boards, now to 50th per ESPN…are we looking at a 2nd round draft pick?Show sponsored by NEBCOOur Sponsors:* Check out Hims: https://hims.com/EARLYBREAKAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy
Kelvin Sampson has a bone to pick with people who don't know how to properly pronounce “Gonzaga”…it's almost like he is a Breaker….Show sponsored by NEBCOOur Sponsors:* Check out Hims: https://hims.com/EARLYBREAKAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy
-Final thoughts on yesterday's games and a look ahead to today's games in the NCAA Tournament..Show sponsored by NEBCOOur Sponsors:* Check out Hims: https://hims.com/EARLYBREAKAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy
-Final plug for getting your brackets filled out and our official tournament champ pick…come to Wings and Rings!!Sponsored by NEBCOOur Sponsors:* Check out Hims: https://hims.com/EARLYBREAKAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy
-2 more games tonight in the First Four games in Dayton…will the Stool be watching?Show sponsored by NEBCOAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy
-First Four begins tonight in Dayton with St. Francis/Alabama State and North Carolina/San Diego State…who wins?Show sponsored by NEBCOOur Sponsors:* Check out Hims: https://hims.com/EARLYBREAKAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy
-Final thoughts on the NCAA Tournament bracket and who got screwed and who got a good draw.Show sponsored by NEBCOOur Sponsors:* Check out Hims: https://hims.com/EARLYBREAKAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy
-A reminder for the schedule for today and tomorrow for state hoops and last thoughts on the B1G Tourney…Show sponsored by NEBCOOur Sponsors:* Check out Hims: https://hims.com/EARLYBREAKAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy
-Preview for what's ahead today in Day 2 of Quarterfinal action in NSAA State Boy's Basketball Tournament…Show sponsored by NEBCOOur Sponsors:* Check out Hims: https://hims.com/EARLYBREAKAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy
-Boys state hoops starts today at PBA/Devaney…Nick on the call next for D1 quarterfinals…#1 Johnson-Brock vs. #8 Elmwood-Murdock from PBA…#4 McCool Junction vs. #5 Elm Creek to followShow sponsored by NEBCOOur Sponsors:* Check out Hims: https://hims.com/EARLYBREAKAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy
Why a Spillover Habit Is So Harmful - Mike CohnWelcome to the second email in the spillover series. We're talking today about why habitual spillover—the phenomenon of unfinished work piling up and carrying forward sprint after sprint—is so harmful to teams.As a reminder, Last week, I explained why spillover happensThis week, I'll describe why habitual spillover is a problemNext week, I'll give you some ideas for how to break your team's rollover habitFinally, I'll talk about what to do with unfinished work when spillover happens Why is Habitual Spillover a Problem?As we talked about last week, teams will sometimes miss their sprint goal, especially when that team is ambitious and aiming high. And that's OK.But teams that develop a consistent pattern of overcommitting and then carrying work forward cause problems for themselves and for the organization as a whole.Teams That Deliver Routinely Are Predictably DependableThe main problem with habitual spillover is Lack of Predictability / Dependability.Every organization benefits from some level of predictability. I worked with a company once that was preparing for its IPO. Despite the tremendous pressure to meet revenue goals prior to going public, the CEO told me he'd happily trade some revenue for greater predictability. Being predictable is that important.Predictability shouldn't be the primary goal for an agile team, but it should be a goal.It's the same in sports. Basketball players strive to make every free throw. But a player who sinks the ball in the basket about 80% of the time is considered a high performer. That player can be reliably counted on to make most of their free throws.Baseball players also strive to get a hit every time they're at bat. And believe it or not, they are considered great, highly predictable hitters, if they manage a hit about 35% of the time—reflected in their .350 batting average.Like those sports players, agile teams are expected to try to deliver everything they think they can, every time. But realistically, if an agile team achieves its goal 60–80% of the time, they are providing a high level of predictability.Teams That Demonstrate Frequent Progress Are Happier & More CreativeA second, related reason your teams want to finish what they've started most of the time is a phenomenon called the power of small wins. In a 2011 study, Amabile and Kramer found that tangible, visible progress is a key factor in people's enjoyment of work, and by extension their level of creativity.It's almost impossible to get a true sense of progress on “mostly done” work because until it's fully done, you can't really gauge the amount of work remaining.This is known as the 90% syndrome. Software projects are 90% done for 90% of their schedule, and that's hard on everyone.When progress stalls and work rolls over, teams lose their sense of accomplishment from making measurable, demonstrable progress. (Want to know more? Read this blog and discover several reasons why it's so important for teams to get to done.)Teams that routinely fail to deliver on their goals lose trust with the organization and miss the sense of accomplishment that comes from finishing. That's why next week's tip will be things you can do to help break your team of the spillover habit so they can succeed with agile,How to connect with AgileDad:- [website] https://www.agiledad.com/- [instagram] https://www.instagram.com/agile_coach/- [facebook] https://www.facebook.com/RealAgileDad/- [Linkedin] https://www.linkedin.com/in/leehenson/
-More updates on NFL free agency signings and what to look for rest of day…Show sponsored by NEBCOOur Sponsors:* Check out Hims: https://hims.com/EARLYBREAKAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy
-It's really hard to think about this week's Big Ten Tournament not featuring Nebraska, but here we are…Show sponsored by NEBCOOur Sponsors:* Check out Hims: https://hims.com/EARLYBREAKAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy
-A reminder for the schedule for today and tomorrow for state hoops and last thoughts on Nebrasketball.Sponsored by NEBCOOur Sponsors:* Check out Hims: https://hims.com/EARLYBREAKAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy
-Preview of tonight's B1G games and reminder of what games are on tap in the State HS Girls Tournament on The Ticket.Show sponsored by NEBCOOur Sponsors:* Check out Hims: https://hims.com/EARLYBREAKAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy
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