POPULARITY
Kohtumine Ukraina helilooja Karmella Tsepkolenkoga Euroopa kultuuripealinnas Tartus, festivalil Balti & Eesti Muusika Päevad.
Since recording this episode, Dr. Karmella Haynes has joined the faculty in the Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech School of Engineering and Emory University School of Medicine. At the time of recording, Karmella was an Assistant Professor in the Ira A. Fulton School of Biological and Health Systems Engineering at Arizona State University. She was also a senior judge for the International Genetically Engineered Machine Competition. Karmella studies synthetic biology, which involves synthesizing DNA outside of a cell and designing those new pieces of DNA so that they can be used for different purposes like stopping cancer cells from growing or helping stimulate tissue regeneration. She enjoys engaging her creative side within the lab as well as outside of the lab. When she is not working, Karmella likes to look at art and to paint paint with oil or acrylic on canvas. She received her Ph.D. in Molecular Genetics from Washington University in St. Louis. Prior to joining the faculty at ASU, Karmella was awarded a Howard Hughes Medical Institute Teaching and Research fellowship at Davidson College, followed by an NIH postdoctoral fellowship at Harvard Medical School. Karmella joined us for an interview to tell us all about her journey through life and science.
Hear from Professor Karmella Haynes, whose work focuses on using synthetic biology to fine tune approaches to epigenetic medicine.
In this episode of the Epigenetics Podcast, we caught up with Karmella Haynes from Emory University to talk about her work on synthetic chromatin epigenetics. The Haynes lab focuses on the design of synthetic chromatin sensor proteins. The first one of this kind, the Polycomb Transcription Factor (PcTF), was published in 2011. It senses H3K27me3 and recruits effector proteins to the sites of this modification. This sensor can be brought into cancer cells to activate hundreds of silenced genes. The lab now focuses on characterizing the effects of these sensor proteins genome wide, and seeks to find a way to deliver those sensor into cancer cells, without affecting healthy cells. In this Episode we discuss how Karmella Haynes got into the field of Epigenetics, how she designed the PcTF sensor proteins, and the way she came to learn how important the right control experiments are. In the end we also discuss her activities to promote diversity and inclusion in science. References Haynes, K. A., & Silver, P. A. (2011). Synthetic Reversal of Epigenetic Silencing. Journal of Biological Chemistry, 286(31), 27176–27182. https://doi.org/10.1074/jbc.C111.229567 Haynes, K. A., Ceroni, F., Flicker, D., Younger, A., & Silver, P. A. (2012). A Sensitive Switch for Visualizing Natural Gene Silencing in Single Cells. ACS Synthetic Biology, 1(3), 99–106. https://doi.org/10.1021/sb3000035 Daer, R. M., Cutts, J. P., Brafman, D. A., & Haynes, K. A. (2017). The Impact of Chromatin Dynamics on Cas9-Mediated Genome Editing in Human Cells. ACS Synthetic Biology, 6(3), 428–438. https://doi.org/10.1021/acssynbio.5b00299 Tekel, S. J., & Haynes, K. A. (2017). Molecular structures guide the engineering of chromatin. Nucleic Acids Research, 45(13), 7555–7570. https://doi.org/10.1093/nar/gkx531 Tekel, S. J., Vargas, D. A., Song, L., LaBaer, J., Caplan, M. R., & Haynes, K. A. (2018). Tandem Histone-Binding Domains Enhance the Activity of a Synthetic Chromatin Effector. ACS Synthetic Biology, 7(3), 842–852. https://doi.org/10.1021/acssynbio.7b00281 Related Episodes Transcription and Polycomb in Inheritance and Disease (Danny Reinberg) Cancer and Epigenetics (David Jones) Contact Active Motif on Twitter Epigenetics Podcast on Twitter Active Motif on LinkedIn Active Motif on Facebook Email: podcast@activemotif.com
It's a girls show with Tam and her friend Karmella. We go through our friendship where we bonded over pressures of being oldest children, being raised Catholic in a Latino household and how therapy has helped us navigate through some difficult feelings. Stigmas still exist and they shouldn't! We hope that people listening will understand that it's ok not to feel 100% all the time
In this end-of-the-year episode, we return from our several-month-long hiatus and talk to Dr. Karmella Haynes about chromatin and epigenetics. Then, we catch up on some news from earlier in the fall, discuss some very endangered birds, and question whether DNA can actually predict what your face looks like. Happy holidays and a happy new year, listeners!
Welcome Back! Join Caliph and Jamese as they take a journey through this new season of American Crime. Synopsis:Luis finds himself sinking into servitude
Welcome Back! Join Caliph and Jamese as they take a journey through this new season of American Crime. Synopsis:Luis, a migrant worker from Mexico,
Dr. Karmella Haynes is an Assistant Professor in the Ira A. Fulton School of Biological and Health Systems Engineering at Arizona State University. She is also a senior judge for the International Genetically Engineered Machine Competition. She received her Ph.D. in Molecular Genetics from Washington University in St. Louis. Prior to joining the faculty at ASU, Karmella was awarded a Howard Hughes Medical Institute Teaching and Research fellowship at Davidson College, followed by an NIH postdoctoral fellowship at Harvard Medical School. Karmella is with us today to tell us all about her journey through life and science.
In this episode we explore our guilty music pleasures. Artists such as Big Freedia, Karmella’s Game, Brooks & Dunn and Craig David. And if you can get through both of us showing off how we can sing along to songs from the 90s (REM and Outkast), you’ll get to hear a story about how Ian was…Read more Episode 17 – Guilty Pleasures
Featuring music by: Taylor Hollingswort, Duct Taped Heart; Carbonfour, From The Start; Karmella’s Game, One Phone Call; Pippa Rogers, Happy; Panic At The Disco with I Write Sins Not TragediesAACMP3