Podcasts about epigenetic

In this presentation I explore the relationship between Bitcoin, time preference, chronic disease, epigenetics, circadian biology, and preventative healthcare. I discuss- Why modern healthcare is fundamentally reactive- The relationship between low time preference thinking and long-term health- Visceral fat, insulin resistance and metabolic disease- How environmental mismatch impacts mitochondrial function- Epigenetic inheritance and future generations- Circadian rhythm disruption and modern technology- Why decentralized approaches to health may become increasingly importantThis episode connects Austrian economics, evolutionary biology, mitochondrial medicine, and modern chronic disease into a unified framework for understanding human health.CONSULT DR MAXHealth consulting, remote - www.drmaxgulhane.com/consultingSUPPORT MY WORK

With over 28 years of experience as an osteopathic physician in family medicine, Dr. Donald Adema is passionate about bringing the wisdom of Scripture to the multifaceted arena of modern medicine. In his work at Chula Vista Christian University, Dr. Adema has been instrumental in bridging the chasm between hope and despair, misinformation and truth, helping students reason through the lens of science and Scripture. In his family practice, he is known for teaching patients to think critically and work with -- rather than against -- God's design for the human body.  Join Dr. Lisa Dunne for today's interview and discover the steps you can take to create a healthy ecosystem for your family. If you'd like to be educated at the feet of giants like Dr. Adema, join us at CVCU! Learn more about our high school dual enrollment programs at www.cvcu.us/dualenroll. Education is formation!K to 12 Rescue Mission: https://www.academicrescuemission.com  Christian Community College: https://www.veritascc.usCVCU degree programs: https://www.cvcu.usBook Dr. Lisa to speak: https://www.DrLisaDunne.com@DrLisaDunne

What if the anxiety, overthinking, people pleasing, emotional shutdown, hypervigilance, burnout, and relationship struggles you experience today… were never actually "you" to begin with? In this deeply personal and profoundly eye-opening solo episode, Darin Olien dives into the hidden nervous system programming formed between the ages of 0 and 8 that silently shapes our adult lives. Drawing from neuroscience, trauma research, attachment theory, epigenetics, somatic healing, and his own emotional breakthroughs, Darin explores how childhood experiences become subconscious operating systems that influence everything from relationships and stress responses to chronic disease and self-worth. This episode is a powerful roadmap toward healing. Darin breaks down the science behind trauma, the ACE study, nervous system dysregulation, emotional patterning, and neuroplasticity, while also sharing practical tools like somatic experiencing, expressive writing, EMDR, and Internal Family Systems to help listeners begin rewiring their emotional lives from the inside out. What You'll Learn How childhood experiences program the nervous system Why most adult emotional reactions are subconscious survival patterns The connection between trauma, stress hormones, and chronic disease How the nervous system stores emotional experiences in the body Why people pleasing, hypervigilance, burnout, and emotional shutdown develop The science behind neuroplasticity and rewiring the brain What the ACE Study revealed about childhood trauma and adult health How trauma impacts the amygdala, hippocampus, and stress-response systems Why emotional patterns are adaptations, not character flaws How epigenetics can pass trauma responses across generations The role of somatic experiencing in trauma healing Practical tools for emotional regulation and nervous system repair Chapters 00:00:03 – Welcome to SuperLife 00:00:32 – Sponsor: Bite Toothpaste and eliminating toxic plastic exposure 00:02:47 – Darin introduces emotional reactions and nervous system triggers 00:03:15 – A personal story about reacting vs responding in conflict 00:03:50 – Emotional shutdowns, rage, withdrawal, people pleasing, and overcorrection 00:04:19 – Darin's physical pain journey and emotional discoveries in 2025 00:04:42 – Birth trauma, childhood conditioning, and nervous system programming 00:05:04 – Why the ages of 0–8 are the most neurologically influential years 00:05:18 – Theta and delta brainwave states during childhood 00:05:55 – How children absorb emotional patterns without filters 00:06:22 – Childhood experiences becoming subconscious operating systems 00:06:44 – Adults unknowingly living through a 5-year-old nervous system 00:07:12 – Why this episode became deeply personal for Darin 00:07:35 – The neuroscience behind stress responses and emotional conditioning 00:08:17 – Brain development, neuroplasticity, and subconscious programming 00:09:13 – How the HPA axis, amygdala, and prefrontal cortex are shaped early in life 00:09:45 – Core childhood questions that program the nervous system 00:10:29 – Why adult stress responses originate in childhood environments 00:11:05 – Research showing childhood adversity alters brain structure and chemistry 00:11:18 – The ACE Study explained 00:11:49 – Why patients losing weight became emotionally overwhelmed 00:12:18 – The ten categories of adverse childhood experiences 00:13:02 – "The health crisis of America begins in childhood" 00:13:36 – How adverse childhood experiences increase disease risk 00:14:03 – Suicide, alcoholism, autoimmune disease, depression, and trauma correlations 00:14:37 – Chronic disease as a nervous system issue 00:15:04 – Survival mode, inflammation, hormonal dysregulation, and emotional scarcity 00:15:42 – Self-sabotage and emotional coping patterns explained 00:16:02 – Why your emotional patterns are not character flaws 00:16:22 – Childhood survival adaptations and nervous system intelligence 00:16:52 – Hypervigilance, people pleasing, rage, emotional shutdown, and fear 00:17:05 – Sponsor: Manna Vitality and frequency-based wellness 00:18:59 – Epigenetics and inherited trauma responses 00:19:22 – Cortisol regulation genes and hyperactive stress responses 00:19:51 – Holocaust survivors, inherited trauma, and generational nervous systems 00:20:19 – Why healing requires nervous system awareness—not just intellectual understanding 00:20:45 – "You were never supposed to get over it—you were supposed to heal from it" 00:21:01 – Real-life examples of subconscious nervous system programming 00:21:16 – Why receiving compliments can feel unsafe 00:21:30 – Darin's personal struggle with overachievement and scarcity programming 00:22:03 – Emotional neglect, chronic striving, and feeling "not enough" 00:22:16 – The nervous system roots of burnout and exhaustion 00:22:23 – Hair-trigger emotional reactions and hyperactive amygdala responses 00:22:38 – Chronic self-abandonment and losing personal boundaries 00:22:52 – Fear of intimacy, trust issues, and emotional safety 00:23:02 – "The body keeps the score" explained 00:23:22 – Trauma stored in posture, breath, digestion, immunity, and emotional regulation 00:23:43 – Harvard research on trauma-related brain changes 00:24:19 – The radical power of neuroplasticity and nervous system rewiring 00:24:48 – Why healing requires conscious participation 00:25:01 – Darin shares how healing changed decades of emotional pain 00:25:33 – Somatic Experiencing and Peter Levine's trauma work 00:25:57 – How animals discharge stress naturally 00:26:23 – Trauma as incomplete physiological responses frozen in the body 00:26:42 – Why humans suppress emotional discharge 00:27:16 – PTSD research and the effectiveness of somatic experiencing 00:27:41 – A step-by-step somatic grounding practice 00:28:14 – Why healing is more powerful with a regulated person beside you 00:28:38 – EMDR and reprocessing traumatic experiences 00:28:55 – Internal Family Systems and the "parts" inside the psyche 00:29:13 – Inner critics, overachievers, and nervous system adaptations 00:29:39 – Compassionately listening to emotional parts instead of suppressing them 00:29:51 – Expressive writing as a trauma healing practice 00:30:22 – The neuroscience behind emotional journaling 00:30:48 – A four-day expressive writing protocol for healing 00:31:05 – "You are not broken" 00:31:16 – Reprogramming the nervous system through love and safety 00:31:37 – Why deep healing happens in the presence of another regulated person 00:31:52 – Darin considers creating a future healing workshop 00:32:04 – Final reflections: "You are not what happened to you" 00:32:12 – Peace. Love. SuperLife. Thank You to Our Sponsors Bite Toothpaste: Go to trybite.com/DARIN20 or use code DARIN20 for 20% off your first order Manna Vitality: Go to mannavitality.com/ and use code DARIN12 for 12% off your order. Join the SuperLife Patreon: This is where Darin now shares the deeper work: - weekly voice notes - ingredient trackers - wellness challenges - extended conversations - community accountability - sovereignty practices Join now for only $7.49/month at https://patreon.com/darinolien     Connect with Darin Olien: Website: darinolien.com Instagram: @darinolien Book: Fatal Conveniences Platform & Products: superlife.com New Show: Roadmap to Happiness Key Takeaway "The emotional patterns, fears, reactions, and coping mechanisms that run your adult life are often survival adaptations created by your nervous system during childhood. They are not your identity. They are not permanent. And through awareness, somatic healing, emotional processing, nervous system regulation, and conscious repetition, those deeply rooted patterns can be rewritten into something healthier, freer, and more aligned with who you truly are." Bibliography/Sources Neuroscience & Early Programming Agorastos, A., Pervanidou, P., Chrousos, G. P., & Baker, D. G. (2019). Developmental trajectories of early life stress and trauma: A narrative review on neurobiological aspects beyond stress system dysregulation. Frontiers in Psychiatry, 10, Article 118. https://doi.org/10.3389/fpsyt.2019.00118 Bolton, J. L., Short, A. K., Simeone, K. A., Daglian, J., & Baram, T. Z. (2019). Programming of stress-sensitive neurons and circuits by early-life experiences. Frontiers in Behavioral Neuroscience, 13, Article 30. https://doi.org/10.3389/fnbeh.2019.00030 Shonkoff, J. P., & Boyce, W. T. (2024). Toxic stress and developmental programming of the HPA axis. Annual Review of Developmental Psychology. https://www.annualreviews.org/journal/devpsych Teicher, M. H., & Ohashi, K. (2023). Childhood trauma and reduced hippocampal, anterior cingulate, and corpus callosum volumes. JAMA Psychiatry. https://jamanetwork.com/journals/jamapsychiatry van der Kolk, B. A. (2014). The body keeps the score: Brain, mind, and body in the healing of trauma. Viking / Penguin. https://www.penguinrandomhouse.com/books/313183/the-body-keeps-the-score-by-bessel-van-der-kolk-md/ ACE Study & Adverse Childhood Experiences Felitti, V. J. (2002). The relation between adverse childhood experiences and adult health: Turning gold into lead. The Permanente Journal, 6(1), 44–47. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112216/ Felitti, V. J., & Anda, R. F. (2010). The relationship of adverse childhood experiences to adult health, well-being, social function, and healthcare. In R. Lanius, E. Vermetten, & C. Pain (Eds.), The impact of early life trauma on health and disease (pp. 77–87). Cambridge University Press. https://doi.org/10.1017/CBO9780511777042 Hillis, S., Mercy, J., Amobi, A., & Kress, H. (2023). Economic burden of health conditions associated with adverse childhood experiences among U.S. adults. JAMA Network Open, 6(12). https://jamanetwork.com/journals/jamanetworkopen Liu, Y., Croft, J. B., Chapman, D. P., et al. (2013). Associations between adverse childhood experiences and health outcomes in adults aged 18–59 years. PLOS ONE, 8(3), e58625. https://doi.org/10.1371/journal.pone.0058625 Epigenetics & Trauma Baratta, M. V., et al. (2021). Epigenetics of childhood trauma: Long term sequelae and potential for treatment. Neuroscience & Biobehavioral Reviews, 132, 1049–1063. https://doi.org/10.1016/j.neubiorev.2021.09.043 Jiang, S., Postovit, L., Cattaneo, A., Binder, E. B., & Aitchison, K. J. (2019). Epigenetic modifications in stress response genes associated with childhood trauma. Frontiers in Psychiatry, 10, Article 808. https://doi.org/10.3389/fpsyt.2019.00808 Provençal, N., & Binder, E. B. (2015). The effects of early life stress on the epigenome: From the womb to adulthood and even before. Experimental Neurology, 268, 10–20. https://doi.org/10.1016/j.expneurol.2014.12.001 Healing Modalities — Research Brom, D., Stokar, Y., Lawi, C., et al. (2017). Somatic experiencing for posttraumatic stress disorder: A randomized controlled outcome study. Journal of Traumatic Stress, 30(3), 304–312. https://doi.org/10.1002/jts.22189 Fratarolli, J. (2006). Experimental disclosure and its moderators: A meta-analysis. Psychological Bulletin, 132(6), 823–865. https://doi.org/10.1037/0033-2909.132.6.823 Gilbert, P. (2009). The compassionate mind: A new approach to life's challenges. New Harbinger Publications. https://www.newharbinger.com/9781572248403/the-compassionate-mind/ Justice Resource Institute. (2022). Evaluation of the efficacy of Internal Family Systems (IFS) therapy for trauma-related symptoms among complexly traumatized adults. ClinicalTrials.gov Identifier: NCT05155930. https://clinicaltrials.gov/ct2/show/NCT05155930 Kuhfuß, M., Maldei, T., Hetmanek, A., & Baumann, N. (2021). Somatic experiencing — effectiveness and key factors of a body-oriented trauma therapy. European Journal of Psychotraumatology, 12(1), Article 1929023. https://doi.org/10.1080/20008198.2021.1929023 Levine, P. A. (2010). In an unspoken voice: How the body releases trauma and restores goodness. North Atlantic Books. https://www.northatlanticbooks.com/shop/in-an-unspoken-voice/ Neff, K. D., & Germer, C. K. (2013). A pilot study and randomized controlled trial of the Mindful Self-Compassion Program. Journal of Clinical Psychology, 69(1), 28–44. https://doi.org/10.1002/jclp.21923 Pennebaker, J. W. (1997). Writing about emotional experiences as a therapeutic process. Psychological Science, 8(3), 162–166. https://doi.org/10.1111/j.1467-9280.1997.tb00403.x Rodenburg, R., Benjamin, A., de Roos, C., Meijer, A. M., & Stams, G. J. (2009). Efficacy of EMDR in children: A meta-analysis. Clinical Psychology Review, 29(7), 599–606. https://doi.org/10.1016/j.cpr.2009.06.008 Schwartz, R. C. (2021). No bad parts: Healing trauma and restoring wholeness with the Internal Family Systems model. Sounds True. https://www.soundstrue.com/products/no-bad-parts Shapiro, F. (2017). Eye movement desensitization and reprocessing (EMDR) therapy: Basic principles, protocols, and procedures (3rd ed.). Guilford Press. https://www.guilford.com/books/Eye-Movement-Desensitization-and-Reprocessing/Francine-Shapiro/9781462532766  

In this episode of the Epigenetics Podcast, we talked with Filippo Rijli from the Friedrich Miescher Institute about his work on transcriptional and epigenetic regulation of craniofacial and neuronal development. Dr. Rijli recalls pivotal moments in his career, including his postdoctoral work where he explored the functions of HoxA2 in craniofacial development. We discuss key findings from his landmark papers, highlighting how individual transcription factors like HoxA2 can dictate the topographic organization of neuronal circuits. His exploration of the whisker-to-barrel cortex circuit in mice unveils how sensory inputs are mapped and processed through precise neuronal connections. This intricate mapping reveals how singular genes can impact the wiring of entire neurological systems. We also reflect on the evolution of scientific communication throughout Filippo's career, from the reliance on faxes and handwritten requests for paper reprints to today's instant access to research through digital platforms. His early experiences have instilled in him a resourcefulness that continues to inform his approach to research, particularly in environments with limited resources where collaboration becomes essential. Our discussion shifts to his recent research endeavors that delve into transcriptional and epigenetic regulation during neuronal and craniofacial development. Dr. Rijli elaborates on a 2015 study which demonstrated how the ectopic expression of HoxA2 could lead to the creation of artificial whisker maps in the brain, providing insights into how transcription factors guide neuronal behavior and circuit formation. His work on the histone methyltransferase EZH2 reveals its crucial role in the tangential migration of cerebellar neurons and the mechanisms that ensure these neurons reach their accurate destinations during development. Dr. Rijli's research further investigates the chromatin landscape of cranial neural crest cells, uncovering how polycomb group proteins maintain a poised state that enables these cells to respond flexibly to environmental signals. This concept of plasticity is particularly relevant in his latest research on nasal chondrocytes, suggesting that these cells retain developmental potential that may be harnessed in regenerative medicine. The discussions hint at a future where understanding these intricate mechanisms could lead to groundbreaking advancements in treating injuries or diseases. Throughout the episode, Dr. Rijli's enthusiasm for discovery is palpable as he shares how each research finding leads to more questions, showcasing the iterative nature of scientific research. This dialogue provides not only a deep dive into his specific studies but also a broader view of how developmental biology continues to evolve, emphasizing the importance of understanding the molecular underpinnings of cellular identity and connectivity. References Oury, F., Murakami, Y., Renaud, J. S., Pasqualetti, M., Charnay, P., Ren, S. Y., & Rijli, F. M. (2006). Hoxa2- and rhombomere-dependent development of the mouse facial somatosensory map. Science (New York, N.Y.), 313(5792), 1408–1413. https://doi.org/10.1126/science.1130042 Di Meglio, T., Kratochwil, C. F., Vilain, N., Loche, A., Vitobello, A., Yonehara, K., Hrycaj, S. M., Roska, B., Peters, A. H., Eichmann, A., Wellik, D., Ducret, S., & Rijli, F. M. (2013). Ezh2 orchestrates topographic migration and connectivity of mouse precerebellar neurons. Science (New York, N.Y.), 339(6116), 204–207. https://doi.org/10.1126/science.1229326 Minoux, M., Holwerda, S., Vitobello, A., Kitazawa, T., Kohler, H., Stadler, M. B., & Rijli, F. M. (2017). Gene bivalency at Polycomb domains regulates cranial neural crest positional identity. Science (New York, N.Y.), 355(6332), eaal2913. https://doi.org/10.1126/science.aal2913 Kessler, S., Minoux, M., Joshi, O., Ben Zouari, Y., Ducret, S., Ross, F., Vilain, N., Salvi, A., Wolff, J., Kohler, H., Stadler, M. B., & Rijli, F. M. (2023). A multiple super-enhancer region establishes inter-TAD interactions and controls Hoxa function in cranial neural crest. Nature communications, 14(1), 3242. https://doi.org/10.1038/s41467-023-38953-0 Related Episodes Chromatin Modifiers and Their Roles in Brain Development (Fides Zenk) Exploring DNA Methylation and TET Enzymes in Early Development (Petra Hajkova) The Role of H3K4me3 in Embryonic Development (Eva Hörmanseder) Contact Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com

Each month, we will highlight a paper published in Aging-US chosen as the “Editors' Choice.” These selections are handpicked by our editors and accompanied by a brief summary, showcasing research with significant impact and novel insights in aging and age-related diseases. __________ In the research paper, titled “Association of epigenetic age acceleration with MRI biomarkers of aging and Alzheimer's disease neurodegeneration,” researchers investigated whether epigenetic clocks of biological aging are associated with MRI markers of brain aging and Alzheimer's disease-related neurodegeneration in 1,196 older women. While none of the five epigenetic clocks examined were linked to accelerated overall brain aging, one measure (AgeAccelGrim2) was associated with MRI patterns related to neurodegeneration. The findings suggest this relationship was largely driven by DNA methylation markers linked to smoking history and changes in frontal and temporal brain regions rather than areas typically affected early in Alzheimer's disease. Overall, the study indicates that epigenetic aging and brain aging may reflect different aspects of the aging process, while highlighting the potential role of smoking-related biological aging in increasing dementia risk. DOI - https://doi.org/10.18632/aging.206369 Corresponding author - Linda K. McEvoy - linda.k.mcevoy@kp.org Abstract video - https://www.youtube.com/watch?v=kZiRjlKnnsI Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206369 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, epigenetic clocks, brain age, biological aging, smoking, frontal lobe To learn more about the journal, please visit https://www.Aging-US.com​​ and connect with us on social media at: Bluesky - https://bsky.app/profile/aging-us.bsky.social ResearchGate - https://www.researchgate.net/journal/Aging-1945-4589 X - https://twitter.com/AgingJrnl Facebook - https://www.facebook.com/AgingUS/ Instagram - https://www.instagram.com/agingjrnl/ LinkedIn - https://www.linkedin.com/company/aging/ Reddit - https://www.reddit.com/user/AgingUS/ Pinterest - https://www.pinterest.com/AgingUS/ YouTube - https://www.youtube.com/@Aging-US Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

In this episode of the Epigenetics Podcast, we talked with Alena van Bömmel from the Biomedical Center (BMC) in Munich about her work on the development of interpretable epigenetic clocks and statistical models of epigenetic dynamics during aging, and the unique epigenetic signatures associated with various cancers, such as brain tumors or leukemias to detect powerful diagnostic markers or predictors of therapeutic response. The Interview starts with Dr. van Bömmel sharing her work on co-occurring transcription factors within cell-type specific enhancers, describing the pioneering use of DNA sequencing and its substantial implications in understanding chromatin accessibility. We explore the findings that revealed varying transcription factor interactions across cell types, emphasizing the complexity inherent in gene regulation. Although her research largely remained in silico, its findings paved the way for potential validation through advanced sequencing techniques. The discussion broadens to encompass Dr. van Bömmel's work on pediatric acute lymphoblastic leukemia, where she elaborates on the epigenetic dynamics observed in patient samples. We discuss her collaboration on a large project that aimed to elucidate the methylation profiles of leukemia patients and how specific epigenetic modifications might indicate cancer subtypes. As the conversation shifts towards aging, Dr. van Bömmel explains her research on DNA methylation trajectories in mouse models. This work unearthed unexpected patterns of abrupt changes in methylation that correspond to distinct life stages, reflecting the potential applicability of these findings in understanding human aging processes. Delving further into her innovative research, she introduces 'Methylizer,' a groundbreaking DNA methylation-based classifier designed for brain tumor diagnostics. We examine the rapid diagnostic capabilities this tool offers in surgical contexts, illustrating a paradigm shift in how epigenetic data can inform real-time clinical decisions. Now at the LMU in Munich, Dr. van Bömmel shares her experiences establishing her lab and her intent to foster a computational-focused research environment that collaborates closely with wet lab scientists. We discuss her aspirations to integrate various layers of epigenetic data through advanced statistical methods and to investigate the aging dynamics of brain cells, specifically in the context of neurodegenerative diseases like Alzheimer's. References Van Bömmel, A., Love, M. I., Chung, H.-R., & Vingron, M. (2018). coTRaCTE predicts co-occurring transcription factors within cell-type specific enhancers. PLOS Computational Biology, 14(8), e1006372. https://doi.org/10.1371/journal.pcbi.1006372 Olecka, M., van Bömmel, A., Best, L., Haase, M., Foerste, S., Riege, K., Dost, T., Flor, S., Witte, O. W., Franzenburg, S., Groth, M., von Eyss, B., Kaleta, C., Frahm, C., & Hoffmann, S. (2024). Nonlinear DNA methylation trajectories in aging male mice. Nature communications, 15(1), 3074. https://doi.org/10.1038/s41467-024-47316-2 Brändl, B., Steiger, M., Kubelt, C., Rohrandt, C., Zhu, Z., Evers, M., Wang, G., Schuldt, B., Afflerbach, A. K., Wong, D., Lum, A., Halldorsson, S., Djirackor, L., Leske, H., Magadeeva, S., Smičius, R., Quedenau, C., Schmidt, N. O., Schüller, U., Vik-Mo, E. O., … Müller, F. J. (2025). Rapid brain tumor classification from sparse epigenomic data. Nature medicine, 31(3), 840–848. https://doi.org/10.1038/s41591-024-03435-3 Related Episodes Evolutionary Epigenetic Clocks and Epigenetic Inheritance in Plants (Frank Johannes) Epigenetic Clocks and Biomarkers of Ageing (Morgan Levine) Epigenetic Consequences of DNA Methylation in Development (Maxim Greenberg) Contact Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com

In this podcast, I hope to share some much-needed optimism with you - I explain in an epic rant, why I'm white-pilled about the future. I address questions ranging from stem cell injections and skincare hacks to epigenetic anti-aging supplements and how to deal with a “blowzy” wife.9:52 Why I'm "white-pilled" about the future32:33 Placental stem cell injections for lady biohackers?39:09 Is Nicotine USP solution caustic for the gut and throat?43:23 Epigenetic anti-aging stack51:02 Does MCT oil cure hangovers?54:24 Are all women like this? How to deal with a “blowzy” wifeRead

First up on the podcast, Online News Editor David Grimm shares a batch of fun stories with podcast host Sarah Crespi—from spider hearts racing when traffic gets loud to a disease-preventing house. Staff Writer Adrian Cho hops in to help discuss the possibility of black holes without singularities at their center. Next on the show, epigenetics has become a hot topic in pop science but the ethical conversation is not keeping up. The idea that parents can pass down epigenetic marks from environmental toxins or trauma to their children—without changes in DNA—has been around for decades but the research in people is lacking. Jackie Leach Scully, a professor of bioethics and director of the Disability Innovation Institute at the University of New South Wales, discusses where the research actually is and the concerns that may arise if such marks do appear to impact the young. Last up this week, we are launching our 2026 biography books series with books host Angela Saini and Science books editor Valerie Thompson. The pair discusses the difficulty of picking biographies and what can be learned about science, fame, and researchers as people from reading these types of books.   This week's episode was produced with help from Podigy. About the Science Podcast Learn more about your ad choices. Visit megaphone.fm/adchoices

First up on the podcast, Online News Editor David Grimm shares a batch of fun stories with podcast host Sarah Crespi—from spider hearts racing when traffic gets loud to a disease-preventing house. Staff Writer Adrian Cho hops in to help discuss the possibility of black holes without singularities at their center. Next on the show, epigenetics has become a hot topic in pop science but the ethical conversation is not keeping up. The idea that parents can pass down epigenetic marks from environmental toxins or trauma to their children—without changes in DNA—has been around for decades but the research in people is lacking. Jackie Leach Scully, a professor of bioethics and director of the Disability Innovation Institute at the University of New South Wales, discusses where the research actually is and the concerns that may arise if such marks do appear to impact the young. Last up this week, we are launching our 2026 biography books series with books host Angela Saini and Science books editor Valerie Thompson. The pair discusses the difficulty of picking biographies and what can be learned about science, fame, and researchers as people from reading these types of books.   This week's episode was produced with help from Podigy. About the Science Podcast Learn more about your ad choices. Visit megaphone.fm/adchoices

Aging has long been linked to a range of biological processes, including cellular senescence, epigenetic changes, and chronic tissue remodeling. Yet, these explanations often describe what happens during aging rather than why certain age-related diseases, such as fibrosis, continue to progress over time. In conditions like idiopathic pulmonary fibrosis (IPF), a key question remains: what drives the persistent activation of cells that should normally return to a resting state after injury? Increasing attention has turned to the interaction between cellular signaling pathways and epigenetic regulation as a potential explanation. Understanding how these processes work together to control gene expression and cell behavior is becoming an important focus in uncovering the mechanisms behind age-related disease. A new research paper was published in Volume 18 of Aging-US, titled “P38 MAPK is involved in epigenetic regulation of fibrotic genes in replication induced senescence in lung fibroblasts.” The study was led by first author Shan Zhu and corresponding author Yan Y. Sanders from the Department of Biomedical and Translational Sciences, Eastern Virginia Medical School (Macon & Joan Brock Virginia Health Sciences at Old Dominion University), in collaboration with Jennifer Q. Zhou, Kan Wang, and Ming-lei Guo from the same institution. Full blog - https://aging-us.org/2026/04/p38-mapk-driven-epigenetic-regulation-identified-as-a-key-mechanism-in-lung-fibrosis/ Paper DOI - https://doi.org/10.18632/aging.206357 Corresponding author - Yan Y Sanders - sandery@odu.edu Abstract video - https://www.youtube.com/watch?v=yP0CwWMUhnY Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206357 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, senescence, fibroblast activation, p38 MAPK, lung fibrosis, H4K16Ac To learn more about the journal, please visit https://www.Aging-US.com​​ and connect with us on social media at: Bluesky - https://bsky.app/profile/aging-us.bsky.social ResearchGate - https://www.researchgate.net/journal/Aging-1945-4589 X - https://twitter.com/AgingJrnl Facebook - https://www.facebook.com/AgingUS/ Instagram - https://www.instagram.com/agingjrnl/ LinkedIn - https://www.linkedin.com/company/aging/ Reddit - https://www.reddit.com/user/AgingUS/ Pinterest - https://www.pinterest.com/AgingUS/ YouTube - https://www.youtube.com/@Aging-US Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

In this episode of the Epigenetics Podcast, we talked with Iva Tchasovnikarova from the Wellcome Trust Cancer Research UK Gurdon Institute about her work on heterochromatin formation and epigenetic control. We begin with Dr. Tchasovnikarova's journey into the field of biology, tracing her roots back to her formative years and the pragmatic guidance of her parents. Despite initial uncertainty about her career path, it was her mother's passion for teaching biology that ultimately inspired her to pursue a degree in the subject. As Dr. Tchasovnikarova introduces her current role as a group leader at the Gurdon Institute and an assistant professor at the University of Cambridge, she highlights her early work during her PhD which yielded a first-author publication in Science. She reflects on the serendipitous aspects of this experience, detailing a project where she utilised a novel genetic screening system to uncover a repressor complex named HUSH, a pivotal discovery that has implications for understanding transcriptional repression mechanisms in vertebrates. The conversation progresses into her postdoctoral research, where she further explored the HUSH complex's role alongside another complex, HUSH2. This expansion of her research reveals fascinating insights into how these complexes interact and their potential significance in regulating gene expression, particularly concerning immune responses to viral infections. Dr. Tchasovnikarova outlines her systematic approach to unraveling these complexities, emphasizing the role of reporter systems and genetic screens in uncovering uncharacterized genes and their functions. In discussing her transition to starting her own lab, Dr. Tchasovnikarova shares her excitement about utilizing methods she developed during her postdoc to discover new regulatory mechanisms. She describes specific experiments that have led to groundbreaking findings, including the characterization of CRAMP1, a regulator of linker histones, which plays a crucial role in the function of the polycomb repressive complex. The intricate relationships between these elements underscore her commitment to understanding the nuances of epigenetic regulation and genome stability. References Tchasovnikarova, I. A., Timms, R. T., Matheson, N. J., Wals, K., Antrobus, R., Göttgens, B., Dougan, G., Dawson, M. A., & Lehner, P. J. (2015). GENE SILENCING. Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells. Science (New York, N.Y.), 348(6242), 1481–1485. https://doi.org/10.1126/science.aaa7227 Danac, J. M. C., Matthews, R. E., Gungi, A., Qin, C., Parsons, H., Antrobus, R., Timms, R. T., & Tchasovnikarova, I. A. (2024). Competition between two HUSH complexes orchestrates the immune response to retroelement invasion. Molecular cell, 84(15), 2870–2881.e5. https://doi.org/10.1016/j.molcel.2024.06.020 Related Episodes Heterochromatin Protein 1 and its Influence on the Structure of Chromatin (Serena Sanulli) Heterochromatin and Phase Separation (Gary Karpen) Polycomb and Three-Dimensional Genome Organisation (Oliver Bell) Contact Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com

BUFFALO, NY — April 23, 2026 — A new #research paper was #published in Volume 18 of Aging-US on April 7, 2026, titled “Association of epigenetic age acceleration with MRI biomarkers of aging and Alzheimer's disease neurodegeneration.” The study was led by first and corresponding author Linda K. McEvoy from the Kaiser Permanente Washington Health Research Institute, in collaboration with a multidisciplinary team of researchers across leading institutions in the United States and Europe. In this study, the researchers examined whether epigenetic measures of biological aging are associated with structural brain changes linked to aging and Alzheimer's disease. Using data from 1,196 older women enrolled in the Women's Health Initiative Memory Study, they analyzed five widely used epigenetic clocks and compared them with MRI-derived measures obtained approximately eight years later. The findings revealed a clear distinction between different aspects of aging. None of the epigenetic clocks were associated with accelerated brain aging as measured by the SPARE-BA index, a composite MRI marker of brain age. However, one specific clock—AgeAccelGrim2—was significantly associated with the Alzheimer's Disease Pattern Similarity Score (AD-PS), a validated imaging biomarker linked to increased risk of dementia. Further analyses suggested that this association was largely driven by epigenetic signatures related to smoking exposure. In particular, a DNA methylation marker reflecting cumulative smoking history was linked to reduced frontal and temporal lobe volumes—regions commonly affected in age-related neurodegeneration. Notably, no significant associations were observed with hippocampal or entorhinal cortex volumes, areas more directly implicated in early Alzheimer's pathology. “Taken together with prior findings, these results suggest that measures of epigenetic and brain age acceleration capture different aspects of biological aging, and that AgeAccelGrim2 is predictive of neurodegenerative changes associated with smoking that increase risk of dementia.” The study highlights the complexity of biological aging and underscores that not all aging biomarkers reflect the same underlying processes. While epigenetic clocks are increasingly used to estimate biological age, their relationship with brain structure appears to depend on the specific pathways they capture—particularly those influenced by environmental exposures such as smoking. Overall, these findings provide important insight into how molecular measures of aging relate to neuroimaging markers of brain health. By distinguishing between general brain aging and disease-related neurodegeneration, this work helps refine the use of epigenetic biomarkers in aging research and may support future efforts to identify individuals at risk for cognitive decline. DOI - https://doi.org/10.18632/aging.206369 Corresponding author - Linda K. McEvoy - linda.k.mcevoy@kp.org Abstract video - https://www.youtube.com/watch?v=kZiRjlKnnsI Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206369 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, epigenetic clocks, brain age, biological aging, smoking, frontal lobe To learn more about the journal, please visit https://www.Aging-US.com​​ and connect with us on social media at: Bluesky - https://bsky.app/profile/aging-us.bsky.social ResearchGate - https://www.researchgate.net/journal/Aging-1945-4589 X - https://twitter.com/AgingJrnl Facebook - https://www.facebook.com/AgingUS/ Instagram - https://www.instagram.com/agingjrnl/ LinkedIn - https://www.linkedin.com/company/aging/ Reddit - https://www.reddit.com/user/AgingUS/ Pinterest - https://www.pinterest.com/AgingUS/ YouTube - https://www.youtube.com/@Aging-US Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

For years, I couldn't give myself permission to heal.My parents were good to me. They loved me. By every conventional measure, I had a good life — and that made it almost impossible to look at my own pain and call it what it was.Then I read Mark Wollyn's book and everything shifted.The pain you're carrying doesn't have to have started with you. Your parents went through things. Their parents went through things. All of that unresolved fear and survival patterns lives in the body, gets passed forward, and becomes the water you swim in without ever knowing it's there.That realization didn't break me. It freed me.And now, standing at the threshold of fatherhood, this conversation has never felt more personal. Epigenetic research shows that a father's stress profile and unresolved patterns imprint on his child. That knowledge has made me more intentional about my own healing than anything else ever has.This episode is for anyone who has ever felt like something was off but couldn't explain why.What You'll Discover:The difference between attachment trauma and generational trauma — and why your body can't always tell them apart.Why you can have a good childhood and still carry deep wounds — the pain you're holding may have started with someone you never even met. Science now proves this is not metaphor. It's biology.What epigenetic trauma transfer actually means — and the studies that prove unresolved trauma leaves a measurable signature in DNA that passes to the next generation.Why your intimate partner is your most powerful healing container — what's unresolved with your mother gets projected onto your partner. That's not a flaw. That's the doorway.What epigenetic resilience means — healing doesn't just stop the transmission of trauma. It actively passes forward a signature of strength to every generation that follows.The Biggest Takeaway:You are not broken. You are carrying something that was never fully yours.When you heal, your DNA changes. What passes forward to the next generation shifts — not the wound, but the resilience.If you are thinking about becoming a parent, this is the most important work you can do. Not the nursery. Not the savings account. Your nervous system. Your unresolved patterns.That is the inheritance that matters most.It didn't start with you. But it can end with you.Connect:

Nothing in biology is random. Not growth. Not metabolism. Not disease. What we will explore today is the reality that the earliest inputs in life: nutrition, environment, signaling, don't just influence outcomes… They shape them. They write the first draft. And if you understand that, if you truly let that land, then everything about how we approach pregnancy, childhood, and prevention begins to shift. From reaction…to intention. From downstream management…to upstream design. Why This Conversation Matters This episode is not just another discussion. In many ways, it is ground zero. Because if you don't understand this layer, the imprinting, the epigenetic programming, the responsiveness of biology to environment, then everything that follows in this podcast…becomes harder to fully see. But once you do see it, the picture sharpens. You begin to understand:why trajectories diverge early, why children present so differently and why the same diagnosis can have completely different roots. This is the beginning of a new map. And maps matter. Gratitude to Today's Guests I want to take a moment to acknowledge the voices you heard today—because this kind of thinking doesn't happen by accident. Lucia Aronica Dr. Aronica is a Stanford scientist and a global authority in nutritional epigenetics, helping clinicians understand that food is not simply fuel—it is biological information that actively programs gene expression. She created Stanford's first courses in nutritional epigenetics and pioneered the Epinutrition framework, a clinical model that reframes nutrition as signaling, not supplementation. You may recognize her from the Netflix documentary You Are What You Eat: A Twin Experiment, and she is now launching the world's first Clinical Epinutrition Certification, training health professionals to use food as epigenetic medicine. Emily Stone Rydbom Emily is a clinical nutritionist, researcher, and digital health founder working at the frontier of precision maternal nutrition. As Founder and CEO of GrowBaby Health, and through her work with GrowHealth Technologies, she is building AI-enabled systems that integrate nutrition directly into standard obstetric care. With over 14 years of clinical experience, she has helped pioneer the “Standard of Care PLUS” model, demonstrating meaningful reductions in preterm birth and gestational diabetes in high-risk populations. She is also a co-investigator on the ROOT Study—bringing this work directly into real-world maternal care here in North Carolina. Samantha N. Fessler Dr. Fessler brings a deep scientific lens to the intersection of metabolism, inflammation, and perinatal nutrition. With a PhD in Exercise and Nutritional Sciences from Arizona State University, her work has focused on how nutritional strategies can modulate the interplay between immune signaling and metabolic function to improve outcomes for mothers and children. As Director of Scientific Affairs at Needed, she helps translate rigorous science into actionable, evidence-based approaches that clinicians and families can actually use. Randy L. Jirtle And finally, Dr. Randy Jirtle—joining us again—whose work, quite simply, changed how we understand biology. A pioneer in epigenetics and genomic imprinting, Dr. Jirtle's research on the agouti mouse model demonstrated for the first time that environmental inputs—particularly nutrition and chemical exposure—could directly alter gene expression across generations. His work reframed the gene from a fixed sentence…to a responsive system. In fact, Time Magazine once described it this way:“A gene represents less of an inexorable sentence and more of an access point for the environment to modify the genome.” He is a Professor of Epigenetics at North Carolina State University and Senior Scientist at University of Wisconsin–Madison and remains, at his core, a deeply curious thinker. And that curiosity… is what moved this field forward. Final Thought: If there is one takeaway from today, it is this: The environment is not acting on the child. The child is responding to the environment. And that response…is being written into biology. Dr. M

BUFFALO, NY – April 15, 2026 – A new #research paper was #published in Volume 17 of Oncotarget on March 31, 2026, titled “Epigenetic dysregulation and biological function of PDX1 in prostate cancer.” The study was led by first author Tayo A. Adeyika and corresponding author Bernard Kwabi-Addo from Howard University, Washington, DC. The team explored the role of the pancreatic and duodenal homeobox 1 (PDX1) gene in prostate cancer, with a focus on its epigenetic regulation and biological function. Their analysis identified PDX1 as differentially hypermethylated in prostate cancer tissues compared to normal prostate samples, alongside a paradoxical increase in protein expression in tumor tissues. Experiments in prostate cancer cell lines showed that PDX1 overexpression significantly enhanced cell proliferation and migration, while knockdown of PDX1 suppressed these tumor-associated behaviors. These findings point to a clear role for PDX1 in promoting aggressive cancer phenotypes. The work further shows that PDX1 regulates key metabolic, inflammatory, and epithelial–mesenchymal transition (EMT) pathways, including genes such as INSR, IGF1R, TWIST1, and SNAI1. Notably, these effects were more pronounced under high-glucose conditions, suggesting a link between metabolic state and prostate cancer progression. “Overall, our findings suggest that PDX1 plays a tumor-promoting role in human PCa cells by influencing expression of metabolites in insulin, inflammatory, and epithelial-mesenchymal transition (EMT) signaling pathways.” The authors conclude that PDX1 may represent a potential therapeutic target, particularly in the context of metabolic disorders such as obesity and diabetes, which are known to influence prostate cancer risk and progression. Their findings provide new insight into the interplay between epigenetics, metabolism, and tumor biology in prostate cancer. DOI - https://doi.org/10.18632/oncotarget.28854 Correspondence to - Bernard Kwabi-Addo - bkwabi-addo@howard.edu Abstract video - https://www.youtube.com/watch?v=itYVsyXJJoE Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28854 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, PDX1, DNA methylation prostate cancer, shRNA knockdown, over-expression, glucose To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

Dr. Deb Muth February 2026, 3 million documents released, a network exposed. But here’s what no one is sayingThe trauma of trafficking doesn’t end when the victim escapes It doesn’t even end when that survivor’s lifetime. It writes itself into DNA. It alters the stress response of children not yet born. And it creates epigenetic markers that echo through 3, 4, and even 5 generations. This is not a metaphor, this is molecular biology. And if we don’t understand how deeply trauma sees itself. Biologically, genetically, and spiritually, we will never understand why autoimmune disease, addiction, and chronic illness are epidemic in families that carry this hidden history. Today, we’re going deeper than headlines. We’re going into the cells, the genes, and the soul. Welcome back to Let’s Talk Wellness Now. We’re here to uncover root causes, explore regenerative medicine, and empower you to heal from the inside out. I’m Dr. Deb, your medical detective, and today we’re confronting one of the most important and least discussed wellness topics of our time. How the exploitation and trafficking of women and children doesn’t just harm individuals, it damages bloodlines. And if you’re someone who carries an unexplained chronic illness, autoimmune disease, addiction, or trauma that seems to have no clear origin, this episode may finally connect the dots. Grab your cup of tea or coffee, settle in, and let’s go deep into this subject. Can you put an ad sponsor right here before we get started? Let’s start with what just happened. In February of 2026, the Department of Justice released over 3 million pages of documents related to Jeffrey Epstein. According to The Guardian, on February 2nd, 2026, these files contained allegations that Epstein didn’t just abuse women, he provided them to other powerful men. One accuser identified Harvey Weinstein from a photo lineup. Describing coercion and payment. Another FBI document described threats of force. Lativia launched a criminal investigation after the files linked Epstein’s network to modeling agencies overseas. But here’s what I need you to understand. As a practitioner who treats trauma survivors, Epstein’s operation was not new. It was ancient. From Mesopotamian slave codes to Roman markets to the transatlantic trade, trafficking has always been about the same thing. Power, and exploiting vulnerability for profit. The tools change. Private jets instead of ships, social media instead of market squares. But the wound, it’s identical. And that wound… It doesn’t heal when the victim is freed. It embeds itself into biology. Let me explain what happens when a human being experiences the kind of trauma that trafficking creates. The immediate biological response. When someone is trafficked, their body enters a state of chronic survival mode. The autonomic nervous system, which controls unconscious functions like heart rate, digestion, immune response, it gets locked into a fight or flight. Cortisol, the primary stress hormone, floods the system. At least, at first. This is protective. But when the threat never ends, when abuse is daily, when escape is impossible, cortisol stays elevated for months and even years. And here’s what chronic cortisol does. It suppresses immune function, making the body vulnerable to infections, cancer, and autoimmune disease. It disrupts the gut microbiome, leading to leaky gut, food sensitivity, and systemic inflammation. It dysregulates hormone production, thyroid sex hormones, insulin, and it creates metabolic chaos. It damages the hippocampus, the part of the brain region responsible for memory and emotional regulation. But it goes deeper than that. Cellular memory, trauma written into our tissues. Research published in the Biological Psychiatry of 2025 and Frontiers in Psychiatry 2025 shows that trauma doesn’t just affect the brain, it reprograms cells throughout the body. Mitochondria, the energy factories inside every cell, shift from producing ATP energy to producing reactive oxygen species, stress signals. This is why trauma survivors often develop chronic fatigue syndrome. That cortisol, over time, starts to dive down, and eventually can’t be produced when it’s supposed to be during a traumatic episode, and it stays at this low level, creating what we now know as chronic fatigue syndrome. Inflammatory genes turn on and stay on, even after the threat is gone. This is why we see such high rates of autoimmune disease, lupus, rheumatoid arthritis, MS, inflammatory bowel disease, in trafficking survivors. The fascia, the connective tissue that wraps every muscle and organ, stores trauma physically. This is why survivors develop chronic pain, fibromyalgia, and tension that no amount of massage can release. The body literally remembers the violation at a cellular level. The ACE study, Childhood Trauma as a Disease Predictor, the CDC’s Adverse Childhood Experiences Study in 2025, showed that 64% of the U.S. adults had experienced at least one ACE abuse. neglect, or household dysfunction. And nearly 1 in 6 has experienced 4 or more. And the data is devastating. The ACE that you have maybe experienced, if you have had this, you have a higher risk for heart disease, stroke, cancer, diabetes, autoimmune disease, depression, suicide, and addiction. Trafficking survivors often score 8, 9, or 10 out of a 10 on the ACE scale. Their bodies are biologically aged by trauma. And according to the VA’s National Center for PTSD, PTSD is associated with excess mortality, meaning survivors die younger, not just from suicide, but from the stress related to chronic disease. Now, here’s where it gets even more profound. What is epigenetics? Well, your DNA is like a library of instructions, but not every book is open all the time. Epigenetics is the system that decides which genes get turned on. or off, without changing the DNA sequence itself. And here’s the critical discovery. Trauma can change those epigenetic marks, and those marks can be passed to your children. The Science of Inherited Trauma. The studies on the Holocaust survivors and their descendants showed that children and grandchildren of trauma survivors had altered stress hormone regulation, even though they never experienced the original trauma themselves. Research on famine shows in the Netherlands during World War II, Found that children born to mothers who were pregnant during starvation had higher rates of obesity, diabetes, and heart disease decades later. This happens because stress during pregnancy alters the developing fetus’ stress response system, and when a pregnant woman is trafficked, abused, or living in chronic fear, her elevated cortisol levels cross the placenta, and the baby’s developing brain is bathed in stress hormones. And the child’s HPA access, the stress regulation system, Is programmed for hypervigilance. The child is born with a biological predisposition to anxiety, depression, autoimmune disease, and addiction. And it doesn’t stop there. That child grows up, and if they have children, their altered stress response can influence the next generation through epigenetic inheritance, and through the environment they create. This is why we see patterns of addiction, autoimmune disease, and mental illness running through families, even when there’s no clear genetic mutation. It’s not just genetics, it’s inherited trauma written into gene expression. There is also a spiritual dimension to this. There’s something beyond biology here, something that science is only beginning to touch. Survivors often describe feeling disconnected from their bodies, as if their spirit left during the abuse. And never fully returned. This is disassociation, a survival mechanism. But in many healing traditions, somatic therapy, internal family systems, even ancient spiritual practices, there’s recognition that trauma fragments the self. And healing isn’t just about regulating cortisol or repairing the gut, it’s about reuniting the spirit with the body. It’s about teaching the nervous system that it’s finally safe to be fully present once again. And when that happens, when one person heals that fracture, it changes the trajectory for everyone else who comes after them. So what do we do with this knowledge? Well, first. Trauma-informed root cause medicine. Healing trafficking survivors and their descendants requires more than talk therapy. It requires nervous system regulation, vagal nerve stimulation, somatic experience, breathwork. Gut healing, repairing the microbiome, addressing that leaky gut, and reducing the inflammation. Hormone balancing, supporting adrenal function, thyroid, and sex hormones, detoxification, clearing accumulated toxins that the stressed body couldn’t process, both physically and emotionally. Nutritional restoration. Replenishing the nutrients depleted by chronic stress. This is functional medicine. This is what I do every day with my team. Second, we need epigenetic reversal, and that is actually possible. Here’s the hope. Epigenetic marks can be changed. Studies show that meditation therapy, safe relationships, and even nutrition can reverse some of the epigenetic damage caused by trauma. Every time a survivor learns to regulate their nervous system, they’re not just healing themselves, they’re changing what gets passed to the next generation. Third, we have to speak the truth. Silence protects the perpetrators. Truth-telling breaks generational curses. And every time we name trafficking for what it is, a crime that damages biology, genetics, and spirit, we create the space for healing. Thank you for going deep with me today on Let’s Talk Wellness Now. If this episode moved you, share it, because healing begins when we stop pretending trauma is only psychological, and we start treating it as a biological, genetic, and spiritual crisis that it truly is. If you or someone you love needs trauma-informed care, visit serenityhealthcarecenter.com or explore our functional medicine platform at venari.com. Survivors seeking support can reach the National Human Trafficking Hotline at 1-888-373-7888. Join our Seen at Last Facebook group, which is a free community where we support women to be seen at last. I’m Dr. Deb. Take care of your body, mind, and spirit. Be well, and we’ll see you on the next episode.The post Episode 260 – How Trauma Passes Through Generations: Epigenetics, Trafficking and Chronic Illness first appeared on Let's Talk Wellness Now.

Each month, we will highlight a paper published in Aging-US chosen as the “Editors' Choice.” These selections are handpicked by our editors and accompanied by a brief summary, showcasing research with significant impact and novel insights in aging and age-related diseases. _____ In this study, titled “Plant-based dietary patterns are associated with slower epigenetic aging,” the researchers examined whether plant-based dietary patterns are linked to biological aging in large, diverse U.S. populations. Using data from the Atherosclerosis Risk in Communities (ARIC) Study and National Health and Nutrition Examination Survey (NHANES), they analyzed several versions of plant-based diet scores that reflect higher intake of plant foods and lower intake of animal products, as well as distinctions between healthy and less healthy plant-based foods. They then compared these dietary patterns with DNA methylation-based “epigenetic clocks,” which estimate biological age, including GrimAge2, PhenoAge, and HannumAge. The results showed that greater adherence to overall plant-based diets, provegetarian diets, and especially healthy plant-based diets was consistently associated with slower epigenetic aging, meaning participants appeared biologically younger than their chronological age. In contrast, diets higher in less healthy plant-based foods did not show the same benefits. The findings suggest that diets emphasizing whole plant foods and limiting animal products may help slow biological aging at the molecular level. DOI - https://doi.org/10.18632/aging.206362 Corresponding author - Hyunju Kim - hyunjuk1@uw.edu Abstract video - https://www.youtube.com/watch?v=FcJ7oEZ-KFk Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206362 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, plant-based diets, DNA methylation, epigenetic aging, all-cause mortality, middle-aged adults To learn more about the journal, please visit https://www.Aging-US.com​​ and connect with us on social media at: Bluesky - https://bsky.app/profile/aging-us.bsky.social ResearchGate - https://www.researchgate.net/journal/Aging-1945-4589 X - https://twitter.com/AgingJrnl Facebook - https://www.facebook.com/AgingUS/ Instagram - https://www.instagram.com/agingjrnl/ LinkedIn - https://www.linkedin.com/company/aging/ Reddit - https://www.reddit.com/user/AgingUS/ Pinterest - https://www.pinterest.com/AgingUS/ YouTube - https://www.youtube.com/@Aging-US Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Azim Surani, Director of Research at the Gurdon Institute and Professor Emeritus at University of Cambridge, received the Kyoto Prize in Basic Sciences, specifically in the field of Life Sciences and Medicine, for his work in demonstrating how male and female mammalian genomes receive distinct imprints during germ cell development. Genomic imprinting introduced a novel concept to Mendelian genetics and is a now fundamental principle in the life sciences. Surani's research has contributed to developmental biology and epigenetics, along with a wide range of life science fields including physiology, regenerative medicine, reproductive medicine, and plant science. Series: "Kyoto Prize Symposium" [Science] [Show ID: 41117]

Azim Surani, Director of Research at the Gurdon Institute and Professor Emeritus at University of Cambridge, received the Kyoto Prize in Basic Sciences, specifically in the field of Life Sciences and Medicine, for his work in demonstrating how male and female mammalian genomes receive distinct imprints during germ cell development. Genomic imprinting introduced a novel concept to Mendelian genetics and is a now fundamental principle in the life sciences. Surani's research has contributed to developmental biology and epigenetics, along with a wide range of life science fields including physiology, regenerative medicine, reproductive medicine, and plant science. Series: "Kyoto Prize Symposium" [Science] [Show ID: 41117]

Azim Surani, Director of Research at the Gurdon Institute and Professor Emeritus at University of Cambridge, received the Kyoto Prize in Basic Sciences, specifically in the field of Life Sciences and Medicine, for his work in demonstrating how male and female mammalian genomes receive distinct imprints during germ cell development. Genomic imprinting introduced a novel concept to Mendelian genetics and is a now fundamental principle in the life sciences. Surani's research has contributed to developmental biology and epigenetics, along with a wide range of life science fields including physiology, regenerative medicine, reproductive medicine, and plant science. Series: "Kyoto Prize Symposium" [Science] [Show ID: 41117]

Azim Surani, Director of Research at the Gurdon Institute and Professor Emeritus at University of Cambridge, received the Kyoto Prize in Basic Sciences, specifically in the field of Life Sciences and Medicine, for his work in demonstrating how male and female mammalian genomes receive distinct imprints during germ cell development. Genomic imprinting introduced a novel concept to Mendelian genetics and is a now fundamental principle in the life sciences. Surani's research has contributed to developmental biology and epigenetics, along with a wide range of life science fields including physiology, regenerative medicine, reproductive medicine, and plant science. Series: "Kyoto Prize Symposium" [Science] [Show ID: 41117]

Azim Surani, Director of Research at the Gurdon Institute and Professor Emeritus at University of Cambridge, received the Kyoto Prize in Basic Sciences, specifically in the field of Life Sciences and Medicine, for his work in demonstrating how male and female mammalian genomes receive distinct imprints during germ cell development. Genomic imprinting introduced a novel concept to Mendelian genetics and is a now fundamental principle in the life sciences. Surani's research has contributed to developmental biology and epigenetics, along with a wide range of life science fields including physiology, regenerative medicine, reproductive medicine, and plant science. Series: "Kyoto Prize Symposium" [Science] [Show ID: 41117]

Learn how vitamin C reverses gene silencing, supports immunity, and counters modern dietary deficiencies through food and targeted supplementation. #VitaminC #Epigenetics #ImmuneSupport #HealthTalks

BUFFALO, NY — March 31, 2026 — A new #research paper was #published in Volume 18 of Aging-US on March 20, 2026, titled “Plant-based dietary patterns are associated with slower epigenetic aging.” Led by first and corresponding author Hyunju Kim from the Department of Epidemiology and the Cardiovascular Health Research Unit, Department of Medicine, University of Washington, the study examined whether four plant-based diet indices — overall PDI, provegetarian diet, healthy PDI, and unhealthy PDI — were associated with DNA methylation-based measures of epigenetic aging. The authors analyzed data from the Atherosclerosis Risk in Communities (ARIC) Study (n = 2,810) and the National Health and Nutrition Examination Survey (NHANES, n = 2,056), and assessed associations with GrimAge2, HannumAge, and PhenoAge. The researchers found that each standard deviation higher in the overall PDI, provegetarian diet, and healthy PDI was associated with decelerated GrimAge2, while higher overall PDI and provegetarian diet were also associated with decelerated PhenoAge and HannumAge. By contrast, unhealthy PDI was not significantly associated with epigenetic aging. The findings suggest that plant-rich dietary patterns, especially those emphasizing healthier plant foods, may be linked to slower biological aging in largely non-vegetarian populations. “No significant association was observed for unhealthy PDI and any of the DNA methylation-based aging.” The authors note that these are observational data and do not establish causality. They call for longitudinal and interventional studies to determine whether sustained adherence to healthy plant-based dietary patterns can directly influence epigenetic aging and related health outcomes over time. DOI - https://doi.org/10.18632/aging.206362 Corresponding author - Hyunju Kim - hyunjuk1@uw.edu Abstract video - https://www.youtube.com/watch?v=FcJ7oEZ-KFk Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206362 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, plant-based diets, DNA methylation, epigenetic aging, all-cause mortality, middle-aged adults To learn more about the journal, please visit https://www.Aging-US.com​​ and connect with us on social media at: Bluesky - https://bsky.app/profile/aging-us.bsky.social ResearchGate - https://www.researchgate.net/journal/Aging-1945-4589 X - https://twitter.com/AgingJrnl Facebook - https://www.facebook.com/AgingUS/ Instagram - https://www.instagram.com/agingjrnl/ LinkedIn - https://www.linkedin.com/company/aging/ Reddit - https://www.reddit.com/user/AgingUS/ Pinterest - https://www.pinterest.com/AgingUS/ YouTube - https://www.youtube.com/@Aging-US Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Have you felt yourself revert back to a child in the way you react to your kids, or a particular situation?Watching from the sideline, Josh recently had a moment where his inner child wounds collided with the reality of the his son's experience on the soccer field. When we come face-to-face with the dissonance between the way we REACT, and the way we want to ACT, something deeper is often at play. Becoming mindful of those moments, and how we respond to them, influences what we pass onto our kids. In this episode, Josh & Christi talk about how to identify an unhealed inner child “part” of yourself, give examples of redeemed and unhealed epigenetic transmission, and provide a beautiful example of how Jesus meets us right where we are. Time Stamps:0:00 Introduction1:15 The messages we picked up in childhood in order to fit in6:15 How to identify an unhealed inner child “part” of yourself9:13 Examples of epigenetic transmission of unresolved inner child pain17:37 The motivation of our parental decisions20:30 Disappointment, condemnation, and the feelings of Holy Week28:56 How Jesus' restoration of Peter is for all of us Show Notes:Easter is coming up! Get 10 Days of the Easter Story: A Family Experience Through the Feelings of Holy Weekhttps://amzn.to/4lpPGQf Interested in our Spring Love Your Marriage Cohort? Apply now. Starts March 30. https://www.famousathome.com/loveyourmarriage Looking for a marriage intensive with Famous at Home? Apply now.  https://www.famousathome.com/coaching Men, sign up for the Living Legacy Cohort:https://www.famousathome.com/menscoaching Sign up for our email list and Famous at Home Starter Bundle: https://www.famousathome.com/newsletter Download NONAH's single Find My Way Home by clicking here: https://bellpartners.ffm.to/findmywayhome

With Dr. Aleksandra Gajer, a doctor on the cutting edge of functional medicine, I tackle the topic of trauma work: tools, tactics, triumphs, and traps. Reclaim agency, health, and happiness by eight foundational lifestyle pillars, which we'll get into in this wide-ranging discussion of the science of health and the art of transformation...1:50 Trauma resolution: tools, tactics, triumphs, and traps12:53 A sad story with a happy ending18:17 Methylene Blue - a "trauma hack?"19:36 Epigenetic mindset transformation meditation22:06 Why your identity must have plasticity23:51 Neuroinflammation AKA "Cellular fear"29:45 How genes impact psychology and recovery33:00 Addiction - what the mainstream gets WRONG38:05 The primacy of self-knowledge42:18 The most important mindset shift for weight loss57:23 Peptides: GLP1s, Retatrutide, Selank & Semax01:11:41 Polish health hacks01:13:42:19 About The Gayer PracticeRead

BUFFALO, NY — March 10, 2026 — A new #research paper was #published in Volume 18 of Aging-US on March 3, 2026, titled “P38 MAPK is involved in epigenetic regulation of fibrotic genes in replication induced senescence in lung fibroblasts.” Led by Shan Zhu — with corresponding author Yan Y Sanders from the Department of Biomedical and Translational Sciences, Eastern Virginia Medical School (Macon & Joan Brock Virginia Health Sciences at Old Dominion University) — the study examines how the stress-activated kinase p38 MAPK contributes to persistent profibrotic gene expression in replicative (passage-driven) senescence of human lung fibroblasts and in primary fibroblasts from patients with idiopathic pulmonary fibrosis (IPF). Using IMR90 lung fibroblasts at low and high population-doubling levels and primary IPF fibroblasts, the authors show that TGF-β1 upregulates profibrotic genes (α-SMA and Col3A1) in both young and near-senescent cells, but that high-PDL (near-senescent/senescent) fibroblasts exhibit a delayed but sustained p38 MAPK response to TGF-β1. Pharmacological inhibition of p38 MAPK (SB202190) blunted profibrotic transcription and reduced H4K16 acetylation (H4K16ac) enrichment at α-SMA and Col3A1 promoters, indicating an epigenetic mechanism linking p38 signaling to fibrotic gene activation. “These findings suggest that a p38 MAPK–dependent epigenetic mechanism is involved in fibroblast activation, supporting the therapeutic potential of p38 MAPK inhibition for treating age-related fibrotic diseases such as IPF.” The authors place these molecular results in a clinical context: persistent fibroblast activation and senescence are features of IPF and other age-associated fibrotic disorders, and the data here support targeting p38 MAPK to interrupt an epigenetically reinforced profibrotic program. The study used multiple readouts (western blot, RT-qPCR, ChIP for H4K16ac) and included primary IPF cells to strengthen translational relevance, while also noting that further work is required to test safety and efficacy in vivo. The paper outlines clear next steps: determine the upstream triggers that sustain p38 signaling in near-senescent fibroblasts, map the chromatin-level events downstream of p38 that maintain H4K16ac at profibrotic promoters, and evaluate p38 inhibition in animal models of age-related pulmonary fibrosis. The authors also recommend exploring whether epigenetic modulators that reverse H4K16ac enrichment can synergize with kinase inhibition to restore repair capacity without impairing normal tissue healing. DOI - https://doi.org/10.18632/aging.206357 Corresponding author - Yan Y Sanders - sandery@odu.edu Abstract video - https://www.youtube.com/watch?v=yP0CwWMUhnY Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206357 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, senescence, fibroblast activation, p38 MAPK, lung fibrosis, H4K16Ac To learn more about the journal, please visit https://www.Aging-US.com​​ and connect with us on social media at: Bluesky - https://bsky.app/profile/aging-us.bsky.social ResearchGate - https://www.researchgate.net/journal/Aging-1945-4589 X - https://twitter.com/AgingJrnl Facebook - https://www.facebook.com/AgingUS/ Instagram - https://www.instagram.com/agingjrnl/ LinkedIn - https://www.linkedin.com/company/aging/ Reddit - https://www.reddit.com/user/AgingUS/ Pinterest - https://www.pinterest.com/AgingUS/ YouTube - https://www.youtube.com/@Aging-US Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

What if the "bad luck" or repeated trauma in your life isn't a coincidence, but a parasitic distortion pattern woven into your very frequency? Today, we go beyond the veil to reveal how hidden spiritual blockages and dark entities may be hijacking your reality—and the controversial science behind how to finally delete them.Get all of Karen Cheong's offerings at https://www.SphericalLuminosity.com!✨ Download Our FREE Throne Room Meditation✨ ➡️ https://www.truthseekah.com/throne-room-free➡️ Support on Patreon! https://patreon.com/join/truthseekah✅ Get access to 40+ video lessons + Weekly LIVE calls!✅ Worldwide Online Community!✅ Courses, Monthly Webinars, Prayer, Meditation, Discussion✅ TruthSeekah's Meditation Library

In this deeply important conversation, Dr. Daina Parent, ND sits down with Dr. Jannine Krause, ND, acupuncturist, and host of The Health Fix Podcast, to explore practitioner burnout and practical strategies for restoring balance. Dr. Jannine shares her personal journey through burnout in her own clinical practice—what led to it, how she recognized it, and the steps she took to heal and thrive again. This episode offers actionable tools and empowering insights to help practitioners protect their energy, restore nervous system balance, and create sustainable clinical careers. Episode Highlights 1:52 – Dr. Jannine's personal journey with practitioner burnout 5:25 – The Physician Heal Thyself course: why filling your own cup comes first 7:30 – Practical tips for establishing healthy energetic boundaries 11:45 – Simple nervous system regulation strategies  for before, during, and between patient sessions 14:38 – Exercises to tone and strengthen the parasympathetic nervous system 21:21 – The significance of Heart Rate Variability (HRV) 23:06 – Epigenetic testing and biological age: connections to nervous system regulation 25:24 – Daily survival patterns and the power of thought 29:30 – How nutrition and herbs influence nervous system resilience 35:03 – Herbal support for peri- and menopause 35:20 – The role of cleansing and detoxification in resetting the nervous system 38:25 – The most important element of a foundational diet: eating close to nature 40:25 – How homegrown food impacts how we feel in our bodies 43:25 – Self-care advice for practitioners To learn more about Dr. Jannine Krause and her work, listen to The Health Fix Podcast and visit her website at doctorkrausend.com.

What if your “age” isn't just the number on your driver's license? In this episode of Everyday Epigenetics: Raw, Real, Relatable, Susan Robbins pulls back the curtain on epigenetic age testing, what it measures, why it matters, and how it can be one of the most empowering tools in your optimization toolbox. Joined by Dr. Lauren Clark of TruDiagnostic, Susan breaks down epigenetics in a way that finally makes sense: your genes are the hardware, but your epigenome is the software, shaped by stress, sleep, movement, nutrition, environment, and the life you've lived.Then Susan brings you behind the scenes of her own TruAge results with Jess Bonthius (medical science liaison at TruDiagnostic), including a real-time walkthrough of her report and what it means for longevity, healthspan, and the pace at which you're aging. If you've ever feared what a test might reveal, or assumed results would be doom-and-gloom, this conversation offers a different lens: data as a guide, not a verdict. You'll leave understanding how these markers can help you make better decisions now, without panic, perfectionism, or expensive “biohacking” extremes.In This EpisodeA clear “Epigenetics 101” explanation (and what DNA methylation actually is)Genetics vs. epigenetics: why your DNA isn't your destinyWhat epigenetic age testing measures, and why different tests can give different insightsThe three key TruAge clocks: biological age, healthspan-focused aging, and pace of agingSusan's personal results walkthrough (and why lifestyle still matters especially during a hard season)Why low percentile can be a good thing in biological age reportingHow inflammation, recovery, and training load can show up in epigenetic biomarkersThe truth about “optimization”: simple lifestyle changes vs. expensive protocolsLearn more about our guests in the show notes below!Jessica Bonthius and Loren Clarke, M.D. RESOURCES:Shownotes: https://healthyawakening.co/2026/02/16/episode111/Discount code: https://shop.trudiagnostic.com/discount/SUSANGENESConnect with Susan: https://healthyawakening.co/Visit the website: healthyawakening.co/podcastFind listening links here: https://healthyawakening.co/linksP.S. Want reminders about episodes? Sign up for our newsletter, you can find the link on our podcast page! https://healthyawakening.co/podcast

We trace Keren's journey from Israel to LA, how immigration shaped her mental health path, and why depth psychology offers tools to understand intergenerational trauma and rising antisemitism. We share practical advice for finding a safe therapist and for turning inherited pain into resilience.• Soviet Jewish roots, Israeli childhood, move to Los Angeles• Immigration stress as trauma and its lifelong echoes• Shift from pre-med to psychology and LMFT licensure• Why depth psychology goes beyond symptom management• Dissertation on Soviet antisemitism and cultural complexes• Epigenetic and social transmission of intergenerational trauma• Therapy for antisemitism after 10–7 and need for validation• How to choose a culturally competent therapist• Parenting with resilience and repairing family narratives• Balancing practice growth, PhD work, and motherhood• Keren's integrative approach: psychodynamic, EMDR, creative tools• Access, supervision, and building a boutique group practiceYou can find Keren at her practice in Los Angeles, California through her website https://sunraypsychotherapy.com/Visit our sponsor topdogtours.com to book your walking tour today and check them out on social media for offers, discounts, and picturesPlease be sure to follow on Instagram as well as my personal Instagram, which is Shebrew in the CityTopDogToursTopDogTours is your walking tour company. Available in New York, Philly, Boston, & Toronto!Disclaimer: This post contains affiliate links. If you make a purchase, I may receive a commission at no extra cost to you.Support the show

While maternal health has traditionally been central to research on pregnancy and child development, there is growing recognition that paternal factors also play a role, particularly the father's age. Several studies have found a modest increase in risk of neurodevelopmental conditions, including autism spectrum disorder, among children born to older fathers. However, the biological mechanisms underlying this association are still not fully understood. One emerging explanation involves epigenetics, chemical modifications that influence how genes are expressed without altering the underlying DNA sequence. Among these is DNA methylation. Earlier studies have suggested that sperm from older men may carry age-related changes in DNA methylation, but few have explored these patterns on a genome-wide scale or focused specifically on regions that are most likely to influence offspring development. The Study: Exploring Age-Dependent Methylation at Imprint Control Regions in Human Sperm In a study, titled “Age-specific DNA methylation alterations in sperm at imprint control regions may contribute to the risk of autism spectrum disorder in offspring,” published in Aging-US and selected as the Editors' Choice for January, 2026, researchers investigated how DNA methylation patterns in sperm change with age. The study was led by first authors Eugenia Casella and Jana Depovere, with corresponding author Adelheid Soubry from the University of Leuven. Full blog - https://aging-us.org/2026/02/epigenetic-changes-in-sperm-may-explain-association-between-paternal-age-and-autism-risk/ Paper DOI - https://doi.org/10.18632/aging.206348 Corresponding author - Adelheid Soubry - adelheid.soubry@kuleuven.be Video abstract - https://www.youtube.com/watch?v=XC3p49Uw49w Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206348 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, epigenome, sperm, 450K, imprinting, autism To learn more about the journal, please visit https://www.Aging-US.com​​ and connect with us on social media at: Bluesky - https://bsky.app/profile/aging-us.bsky.social ResearchGate - https://www.researchgate.net/journal/Aging-1945-4589 X - https://twitter.com/AgingJrnl Facebook - https://www.facebook.com/AgingUS/ Instagram - https://www.instagram.com/agingjrnl/ LinkedIn - https://www.linkedin.com/company/aging/ Reddit - https://www.reddit.com/user/AgingUS/ Pinterest - https://www.pinterest.com/AgingUS/ YouTube - https://www.youtube.com/@Aging-US Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Canada's healthcare system is under unprecedented strain, with thousands of people experiencing serious harm—or death—while waiting for diagnostic procedures, specialist care, or life-saving treatments. Despite public trust in the system, delays have become a hidden personal risk that most Canadians fail to plan for. As we age, delays in diagnosis and treatment don't just affect outcomes—they accelerate physical decline, cognitive stress, emotional exhaustion, and financial vulnerability. Loss of access means loss of control, which directly undermines resilience, independence, and healthspan.  Ingrid Gahsner approaches healthcare delays through the lens of risk management. Drawing on decades of client experience, she reframes access to care as a foundational planning issue—one that deserves the same attention as financial or retirement planning.You'll discover why healthcare delays must be treated as a real, quantifiable risk, what alternatives exist within Canada and internationally, and how healthcare access planning can reduce physical, emotional, and financial harm—without abandoning public healthcare values. Ingrid Gahsner is a licensed Canadian risk management consultant with over 30 years of experience in insurance, corporate benefits, and compliance. She is the founder of IMI Canada Group Benefits and the author of Off the Wait List, helping Canadians protect their health, time, and financial security through proactive healthcare access planning. Episode Timeline: 00:00 — Why healthcare wait lists threaten healthspan  05:30 — What inspired Off the Wait List 10:25 — Ethical and structural failures in Canadian healthcare 16:20 — "Waiting isn't a strategy" explained 18:45 — How delays accelerate aging physically and emotionally 25:40 — What healthcare access planning really means 28:20 — Private clinics, concierge care, and real options 33:50 — First steps Canadians can take today 38:30 — Final thoughts on personal responsibility and resilience  Connect with Ingrid Gahsner: https://www.imicanada.co https://linkedin.com/in/ingrid-gahsner-b08634262 IG - @imicanada_  Action Steps:  Be Proactive. Download Guide to Nature's Colorful Antioxidants Subscribe to Growing Older Living Younger on your favorite podcast platform and leave a review to help others discover the show.  Join the Growing Older Living Younger Community Connect with Dr. Gillian Lockitch at ASKDRGILL or askdrgill@gmail.com

Epigenetic regulation of gene expression is an important mechanism in development and disease. N6-methyladenosine (m6A) is one of the most prevalent epigenetic modifications for RNA and has been shown to play critical roles in processes such as embryo development, cancer, and stress responses. Our guests today investigate how m6A regulates X chromosome dosage compensation to ensure proper balance of gene expression from X chromosomes between sexes. X-chromosome dosage compensation is accomplished through two complementary mechanisms. First, X-chromosome inactivation (XCI) silences one of the two X chromosomes in female cells. Second, the remaining active X chromosome is transcriptionally upregulated so that its gene expression levels are balanced with those of the autosomes, a process known as X-to-autosome (X-to-A) compensation. The authors dissect the distinct contributions of m6A RNA methylation to XCI versus X-to-A compensation across multiple embryonic lineages, providing deeper insights into the epigenetic regulation of early development.GuestsSrimonta Gayen, PhD, Department of Developmental Biology and Genetics, Indian Institute of Science, IndiaHostJanet Rossant, Editor-in-Chief, Stem Cell Reports and The Gairdner FoundationSupporting ContentPaper link: "The role of m6A RNA methylation in the maintenance of X chromosome inactivation and X-to-autosome dosage compensation in early embryonic lineages," Stem Cell ReportsAbout Stem Cell ReportsStem Cell Reports is the open access, peer-reviewed journal of the International Society for Stem Cell Research (ISSCR) for communicating basic discoveries in stem cell research, in addition to translational and clinical studies. Stem Cell Reports focuses on original research with conceptual or practical advances that are of broad interest to stem cell biologists and clinicians. X: @StemCellReportsAbout ISSCR Across more than 80 countries, the International Society for Stem Cell Research (@ISSCR) is the preeminent global, cross-disciplinary, science-based organization dedicated to advancing stem cell research and its translation to medicine. ISSCR StaffKeith Alm, Chief Executive OfficerShuangshuang Du, Scientific Programs ManagerYvonne Fisher, Managing Editor, Stem Cell ReportsKym Kilbourne, Director of Media and Strategic CommunicationsMegan Koch, Senior Marketing ManagerJack Mosher, Scientific DirectorHunter Reed, Senior Marketing Coordinator

Chronic stress and burnout are often worn as a badge of honor, yet they can be powerful accelerators of biological aging. In this conversation, wellness entrepreneur and educator Erica Jones explains how persistent stress can disrupt sleep, increase inflammation, and influence mitochondrial function, hormones, and even gene expression through epigenetic pathways. Together, with the host, Dr. Gillian Lockitch, we focus on sustainable strategies that busy, high-capacity people can actually maintain - starting with the "unsexy basics" of hydration and sleep, plus boundaries that protect your nervous system. You'll also leave with one simple "try this today" reset to restore perspective when you feel overwhelmed. Erica Jones is a wellness entrepreneur and educator and the co-founder of Elevays, where she helps high performers build sustainable routines that support energy, focus, and longevity without burnout. With a background in biology and an early career in pharmaceutical sales, Erica transitioned into a root-cause approach to health through functional and holistic wellness. She has guided thousands of entrepreneurs, CEOs, and coaches toward greater clarity, balance, and resilience through practical, real-life strategies.   Episode Timeline  00:00 – Opening teaser: stress and biological aging. Why burnout and chronic stress can quietly accelerate aging, and why small daily shifts can help reverse the trajectory.  00:30 – Dr. Gillian Lockitch introduces the episode focus: stress, mitochondria, telomeres, hormones, inflammation, sleep, and longevity.  03:48 – Meet Erica Jones. Erica shares her work helping high performers build sustainable routines that support energy, focus, and longevity.  04:11 – From pharma to holistic wellness. Erica describes her biology background, early pharmaceutical sales career, and the pivot into holistic, root-cause health.  08:39 – The problem with "overwhelming wellness routines" Why drastic overhauls and intense routines backfire for busy people, and how to simplify to what's doable.  09:55 – Non-negotiables: hydration and sleep. The "unsexy basics" that protect the cell: consistent hydration (often with electrolytes) and prioritizing sleep.  11:35 – Electrolytes: a practical tool. Erica recommends an electrolyte option (LMNT) and explains how it can support consistent hydration.  13:48 – Real-life challenges and cravings. Dr. Lockitch shares how health events and medication shifts can change appetite, cravings, and weight management.  16:10 – How stress ages us at the cellular level. Epigenetic alteration, chronic inflammation, and lifestyle patterns that can turn on disease expression over time.  25:05 – What to stop doing now. Protect sleep, reduce late-night screens and blue light, and create boundaries with devices and always-on digital life.  29:28 – A common myth: waiting for the perfect time. Why "I'll get healthy after this busy season" keeps people stuck, and how constraints and commitment create change.  31:16 – Balancing work, family, and self-care. Erica's approach to focus, guilt-free boundaries, and a nightly wind-down routine to prevent burnout.  33:53 – Try this today: step outside. Fresh air and nature as a fast nervous-system reset that restores perspective and supports momentum.  36:00 – Wrap-up and where to connect. How to find Erica's free gift and resources, plus Dr. Lockitch's invitation to schedule a roadmap call.    Resources and Links Mentioned  Erica Jones and Elevays: https://eleves.com  Pinterest: https://www.pinterest.com/elevays/ YouTube: https://www.youtube.com/@Elevays Erica's 5-Minute Daily Detox for Burned-Out Entrepreneurs (Free Download) → https://elevays.kit.com/f0d54afca5    Call to Action  Subscribe to Growing Older Living Younger on your favorite podcast platform. Leave a review to help others discover the show and share the link Join the Growing Older Living Younger Community Contact Dr. Gillian Lockitch  at askdrgill@gmail.com to explore your personal roadmap to longer healthspan and living younger longer. 

We've been told time heals all wounds. Go back to work. Stay busy. But what if decades of stress are still rewriting the body right now? Dr. Karestan Koenen, a Harvard researcher who has followed 100,000 women over twenty years, shares what she's discovered about how unaddressed trauma doesn't fade—it becomes biology. In this conversation, we explore why major disease studies have ignored trauma, how stalking affects women's heart health, and what epigenetics reveals about catching these changes early. In this episode you'll learn: [01:54] The Pattern No One Was Tracking: How clinical observation at the VA revealed PTSD and diabetes worsening together—before research proved it [04:04] Stalking and Heart Disease: Why women on the editorial board said "of course this is true" while men said "there's no way" [05:35] The Gap in Major Disease Studies: Why the cohorts that shaped our understanding of diet, exercise, and disease never measured trauma [11:27] How to Define Trauma: Uncontrollable, unpredictable, and overwhelming—and why the pandemic qualified [14:41] When Coping Mechanisms Take a Toll: How the adaptations that helped us survive can interfere with where we want to go [17:14] Resilience Redefined: Why you can have symptoms and still be making meaning—and why the person in front of you is always a survivor [23:58] Loss of Life Purpose: How retirement, death of a spouse, or role changes directly impact physical health and longevity [28:47] Time Doesn't Heal—It Becomes Biology: Why going back to work and staying busy doesn't make trauma fade [32:33] The Biology of Adversity Project: How epigenetics research may catch changes before chronic conditions develop [34:17] Somatic Practices Without the Story: The future of yoga, breathwork, and body-based approaches for resetting the nervous system Get the full episode breakdown at Biology of Trauma® Podcast - Episode 155: Time Doesn't Heal: What 20 Years of Research Actually Shows Resources/Guides: Biology of Trauma book - Available now everywhere books are sold. Get your copy Free Guide: How Trauma Shows Up in the Body & What To Do About It - Understand why your body responds this way. Learn what helps. Related Podcast Episodes: Episode 86: Is Trauma Genetic or Epigenetic? Insights with Dr. Bruce Lipton Episode 116: The Body Keeps Score: How Trauma Rewires Your Nervous System with Dr. Bessel van der Kolk

Many people believe that memory loss, physical decline, and loss of independence are inevitable parts of aging. But what if that belief is wrong? In this first Growing Older Living Younger episode of 2026, Dr. Gillian Lockitch challenges the outdated narrative that aging automatically means decline. Drawing on decades of medical expertise, cutting-edge epigenetic science, and her own lived experience, Dr. Lockitch explains why growing older is inevitable—but aging poorly is not. This episode introduces the concept of healthspan—the years of life lived with clarity, mobility, independence, and purpose—and shows how healthspan is not fixed by your genes or your chronological age. Instead, it is shaped daily by belief, biology, and small, consistent lifestyle choices that influence how your genes are expressed. Dr. Lockitch also explains why information alone is not enough to create lasting change, and why guided support, accountability, and community are essential for sustainable healthy aging. She outlines the Seven Pillars of the Growing Older Living Younger roadmap and previews two focused coaching pathways launching in 2026: The Ageless Mind Blueprint and The Better Body Healthspan Blueprint. If you've ever wondered whether there is a better way to age—this episode offers clarity, science, and hope. 00:00 – 03:45 | Opening & Welcome "Growing older is inevitable—aging poorly is not". Common fears listeners experience but rarely voice aloud 03:45 – 06:30 | What Is Healthspan—Defining healthspan vs. lifespan "Adding life to your years, not just years to your life" 06:30 – 08:45 | Epigenetics: Why Healthspan Is Modifiable Genes as a blueprint. How lifestyle, nutrition, movement, sleep, stress, and mindset influence gene expression and Why people of the same chronological age age differently 08:45 – 10:30 | Belief Comes First Why belief shapes behavior—and behavior shapes biology, The physiological (not just motivational) basis of belief. Why believing change is possible is essential for sustainable aging 10:30 – 12:40 | Why Information Alone Is Not Enough Knowing vs. doing. Why healthy aging requires guidance, structure, and accountability The role of mentorship, community, and support 12:40 – 17:00 | The Seven Pillars of Growing Older Living Younger Your Genetic Blueprint – Don't let your genes determine your destiny You Are What You Eat – Nourishment vs. toxicity Physical Activity & Posture – Movement, resilience, and recovery Beauty Is Skin Deep – Caring for your skin as a vital organ Mindset, Mindfulness & Mindkeep – Cognitive resilience and presence Choose a Challenge – Growth through discomfort Communication & Connection – You are not alone Personal reflections, including transforming obstacles into opportunities 17:00 – 19:00 | Two New Coaching Pathways for 2026 The Ageless Mind Blueprint Focus: memory, cognition, and fear of dementia The Better Body Healthspan Blueprint Focus: peri- and post-menopausal bone, muscle, joint, and fascial health Same science, same pillars—different emphasis 19:00 – 21:30 | Tools, Ethics, and Lifestyle Support Clarification of Dr. Lockitch's role as a retired physician Evidence-informed epigenetic nutrition, supplementation, and skin-care tools Supporting the body's natural repair and regeneration—no shortcuts 21:30 – 24:00 | Final Reflections for 2026 Small, incremental changes can be transformational You don't need to be perfect—progress matters Why you don't need to do this alone Healthspan extension begins with belief   24:00 – End | Invitation & Closing Invitation to schedule a personal healthspan roadmap call with Dr. Lockitch Encouragement to share the episode and subscribe  The Seven Pillars of Growing Older Living Younger Your Genetic Blueprint – Your genes are not your destiny You Are What You Eat – Nourishment vs. toxicity Physical Activity & Posture – Movement as medicine Beauty Is Skin Deep – Caring for your body's largest organ Mindset, Mindfulness & Mindkeep – Protecting cognitive health Choose a Challenge – Growth requires discomfort Communication & Connection – You are not alone

Dr Michael Hauskeller joins Ethics Talk to discuss his article, coauthored with Liam Shore: "What Are the Most Ethically Salient Implications of Epigenetic Age Testing?"  Recorded September 29, 2025.  Read the full article for free at JournalOfEthics.org

ReferencesGuerra, DJ.2025. Unpublished LecturesHepatology.2023 Apr 17;77(5):1654–1669Comprehensive Gut Microbiota2022, Pages 201-219Dylan, B. 1964. My Back Pages. Byrdshttps://music.youtube.com/watch?v=OADlrLHfYW4&si=Q63xZIE_33GXVYv4

ReferencesMol Immunol. 2017 Apr 1;87:1–11Guerra, DJ 2025 Unpublished LecturesHayward/Pinder/Lodge/Thomas. 1967. Days of Future Passed. Moody Blues.https://music.youtube.com/playlist?list=OLAK5uy_l2x8IxcSnnBm21QUI3aKwu7Sz8thfM-1w&si=9tsIhVrSdLrMn7vG

ReferencesGuerra, DJ.2025 Unpublished LecturesHepatology.2023 Feb 9;78(3):878–895.Mozart, WA. Mass in C Minor, K, 427https://music.youtube.com/watch?v=Ez0kqVShFEs&si=D1MUVoXZIbPxRyM4

The 2025 Medical Innovation Olympics featured one of the most memorable and personal interviews with Amber Salzman, CEO at Epicrispr Biotechnologies, an extraordinary leader with unparalleled sense of purpose, urgency, PhD in mathematics and illustrious track record of success as a pharmaceutical industry executive with over 30 years of experience that included growing revenue, shareholder value, and accelerating innovative treatments. She began her career leading R & D at GSK with a clinical pipeline responsibility for $1.25 billion, prior to serving as CEO at Cardiokine, CEO at Avalanche, co-founder of Annapurna, SAS, CEO of Adverum, Ohana Biosciences. She currently serves on the Osler Diagnostics (UK) and AviadoBio (UK) Boards. In addition to advocating for patients living with rare diseases, Dr. Salzman leads the Stop ALD Foundation, a non-profit medical research foundation focused on developing.In this interview Amber speaks about her personal and family's struggle with neurodegenerative rare diseases and the critical new discoveries in gene regulation to switch genes on and off rather than cut DNA which she has guided and accelerated with the support of an extraordinary team of Nobel Prize laureates and scientists at Epicrispr. 0:00 - Highlight 1 - Amber's Family's Personal Struggle with Rare Neurodegenerative Disease1:02 - Highlight 2 - Patient's Real-World Story from the 9/11 tragedy2:31 - Highlight 3 - Vision & Stamina Needed to Address Unpredictability of Human Biology 4:03 - Speaker Introduction7:19 - Keys to Transition from R & D to CEO/Commercial Leader10:22 - Approach to decision-making as a leader with urgency & purpose14:00 - Epigenetic Editing and How it is different from CRISPR16:36 - Challenges on the journey to Epicrispr's discovery18:14 - Second challenge - finding a gene modulator with which to fuse it 18:49 - Patients vary significantly in how they express their symptoms19:52 - Springbuck Analytics Partnership - Whole Body Imaging21:14 - Recent disappointments from Sarepta in Duchenne's muscular dystrophy25:48 - How Amber's personal family experiences with Genetic Diseases impacted her leadership journey29:47 - When could FSHD patients finally access this new treatment?31:27 - What other disease conditions is Epicrispr considering in its development program?33:27 - Amber's Lessons: Stay focused on patients, learn, and co-develop treatments together

ReferencesHepatology.2023 Feb 9;78(3):878–895.Mozart, WA. 1791. Ave Verum Corpus. K618https://music.youtube.com/watch?v=Z-xMjO0d-pc&si=g1TpOohQQt9forf0Murray, J. 1874 Jolly Old St Nicholas. Instrumentalhttps://music.youtube.com/watch?v=eTHdEA5zh2Q&si=0v0ADs7LhtIu7zqd

ReferencesPharmacological Reviews.2011.NOV.64(1):166-87Hepatology.2023 Feb 9;78(3):878–895.Sci Rep. 2015 Sep 30;5:14692Bach, JS. 1734. Christmas Oratories BV 248.https://music.youtube.com/watch?v=98UjjwzJBFE&si=kd45twdzgpXtJuWL

Katy & Jeannette dive into the question: can movement really change your DNA? Using clear analogies—like libraries, recipes, and sticky notes—they unpack what DNA is, how gene expression works, and what we really mean by epigenetics (the “on top of” changes that influence which genes get used). They explore how exercise can turn the “volume up or down” on metabolic genes, pro-inflammatory markers, and stress protein genes, and how many of these changes involve altering the arrangement and access to DNA within your cells.Using another accessible analogy of spider webs, they explore how forces on cells (through mechanotransduction) act as a powerful, non-chemical “nutrient” that can literally move your DNA and alter epigenetics and gene expression. This is why exercise and everyday movement not only have systemic benefits but also site-specific effects—and why the distribution of movement throughout your body matters just as much as how much you move.Enhanced Show Notes and Full Transcript00:00:23 “You can't change DNA”: Katy's green-room story with a physician who insists DNA is fixed.00:03:33 What is DNA? Jeanette's library-and-recipe analogy explaining DNA and gene expression.00:06:11 Genes as volume controls: How exercise turns gene activity up or down rather than rewriting DNA.00:12:02 Chromatin & compacted DNA: Archival library shelves as a metaphor for genes you rarely “reach for.”00:18:54 Mechanotransduction & spider webs: How movement plucks the cell's “web” and signals the nucleus.00:25:36 Epigenetics explained: Sticky notes, covered keyholes, and how markers sit “on top” of DNA.00:29:28 Epigenetic memory & trained vs. untrained leg study: Why movement has site-specific effects.00:32:17 Listener Question (sponsored by Movemate): Do organs such as the brain, liver, and kidney need specific movements?BOOKS & RESEARCH MENTIONEDMove Your DNA book by Katy Bowman Epigenetic profile of trained vs untrained leg  Walking & blood circulation to the brainPhysical Activity, Gut Motility & ConstipationCONNECT, MOVE & LEARNMovement Advent 2025: 24 Ball Exercises to Balance Tech StressJoin Our Newsletter: Movement Colored GlassesFollow Katy on SubstackTry Katy's Virtual Studio Free for 7 days!MADE POSSIBLE BY OUR WONDERFUL SPONSORS:Movemate: Active standing boards with smoothly articulating wooden slats. Designed to keep you moving without interrupting your focus. Take 15% off until Dec 7th with code MOVEMy Happy Feet: Toe-spacing socks that gently realign toes for comfortable recovery—take 20% off with code MYDNA.Ikaria Design: The Soul Seat® offers height-adjustable, multi-position sitting—get 10% off new chairs and desks with code DNA10.Venn Design: Stylish ball-shaped Air Chairs that encourage dynamic sitting—featuring in our 2025 Movement Advent! Peluva: Five-toe minimalist shoes that move like you do—take 15% off with code NUTRITIOUSMOVEMENT.Smart Playrooms: Beautiful playroom design and movement-rich equipment—save 10% on monkey bars and rock-wall items with code DNA10.Thoughts/questions email us at podcast@nutritiousmovement.comYour Voice on the Podcast: Read The Credits 

If you want to get leaner and live longer check out https://milliondollarbodylabs.com   How can you leverage positive thinking and simple lifestyle habits to change your biological age by a decade?   In this episode, I talked with Jon Sabes, a longevity researcher and entrepreneur. He has worked with biomarkers of aging and health for the life insurance industry. Jon shares how his mother's passing shaped his book, Healthy Wealthy Longevity. I learned about the connection between positive thinking, physical activity, and gene expression through epigenetics. We discussed the importance of mastering the basics: eating whole foods, consistent movement, connection, and purpose. I also asked Jon how tackling difficult physical challenges builds mental resilience and self-belief.   Key takeaways Lifestyle is a powerful driver of longevity: Lifestyle habits strongly influence gene expression (epigenetics). Reprogramming the subconscious is key to health: Override negative thought narratives by intentionally inputting "brain food" (positive psychology) combined with exercise, which can drive positive gene expression. Build mental resilience: Challenging physical activity creates a mental muscle of resiliency, helping overcome negative self-talk and building proof of capability. Focus on the basics before biohacking: Prioritize holistic lifestyle—eating whole foods, constant movement, connecting with others, and having purpose—as these cover 80% of health and longevity needs. The Blue Zones teach the value of community and purpose: Populations living long, happy lives prioritize strong community and purpose, often without being financially rich. Biological age can be measured: Epigenetic biomarkers (DNA methylation patterns derived from a blood test) can reveal a biological age that is older or younger than chronological age. Jon's biological age is about 10 years younger than his chronological age.Healthy & Wealthy Longevity? Ft. Jon Sabes Use prompt journaling: A daily practice of prompt journaling helps self-coach, set intentions, and maintain focus on goals, fostering gratitude and daily improvement. Resources Website: https://longevityfp.com LinkedIn: longevityfp Facebook: LongevityFP Instagram: @longevity.fp Jon Sabes's Book: Healthy Wealthy Longevity   Nate Palmer: The founder of The Million Dollar Body and author of "The Million Dollar Body Method", Nate has been coaching for over 15 years and has worked personally with over 1,000 clients. Website: https://milliondollarbodylabs.com/ Book: The Million Dollar Body Method Lean Energy Stack: https://milliondollarbodylabs.com/pages/lean Instagram: @_milliondollarbody  

We are more than just our DNA. Epigenetics reveals that our genes can be turned "on" or "off" by the experiences of our ancestors—their traumas, their resilience, even their unspoken stories. This inherited emotional blueprint shapes our lives in profound ways, influencing our anxieties, our relationships, and our sense of self.But this code is not our destiny. Ancestral psychotherapy provides the key to rewriting this inherited story. By compassionately engaging with the wounds of our lineage, we can transform these silent echoes from burdens into sources of strength. This is the journey of healing not just yourself, but of reclaiming your entire lineage's potential for wholeness.Ep39 EPIGENETICS: Rewrite Your Story with Keren Goldenberg#Epigenetics #AncestralHealing #InheritedTrauma #GenerationalHealing #RewriteYourStory #AncestralPsychotherapy #HealingTheLineage #BeyondDNA #EmotionalBlueprint #TransgenerationalTrauma #HealingJourney #Resilience #UnspokenStories #ReclaimYourWholeness #DestinyVsDNA

Mainstream medical science tries to convince us that diseases and sickness are passed on genetically, assuring us that there is nothing that can be done. Worse, mainstream medicine then pushes solutions such as genes modification so solve these problems. Epigenetic's is the understanding that most if not all disease and sickness is a result of genetic expression being repressed, while good health is a reflection of genes expressing themselves. The ability for a gene to express itself can be enhanced by ensuring the body is topped off with the 90 essential nutrients it needs.    #BardsFM_HealthAndWellness #Epigenetic's #TheBodyTemple Bards Nation Health Store: https://www.bardsnationhealth.com MYPillow promo code: BARDS Go to https://www.mypillow.com/bards and use the promo code BARDS or... Call 1-800-975-2939.  Founders Bible 20% discount code: BARDS >>> https://thefoundersbible.com/#ordernow Mission Darkness Faraday Bags and RF Shielding. Promo code BARDS: Click here EMPShield protect your vehicles and home. Promo code BARDS: Click here EMF Solutions to keep your home safe: https://www.emfsol.com/?aff=bards Treadlite Broadforks...best garden tool EVER. Promo code BARDS: Click here Natural Skin Products by No Knot Today: Click here Product Store, Ambitious Faith: Click here Health, Nutrition and Detox Consulting: HealthIsLocal.com Destination Real Food Book on Amazon: click here Images In Bloom Soaps and Things: ImagesInBloom.com Angeline Design: click here DONATE: Click here Mailing Address: Xpedition Cafe, LLC Attn. Scott Kesterson 591 E Central Ave, #740 Sutherlin, OR  97479

Learn how to slow, and even reverse, your biological age with cutting-edge science on the molecule that controls your longevity. Host Dave Asprey sits down with Dr. Leonard Guarente, an MIT PhD and one of the most respected longevity researchers in the world, to reveal how NAD+, sirtuins, and DNA methylation clocks can help you hack aging, upgrade your mitochondria, and extend your healthspan. This episode gives you the real science, proven by over 250 studies, behind supplements, nutrition, and biohacking tools that actually work for brain optimization, metabolism, and human performance. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR You'll learn why NAD+ is a master regulator of mitochondrial health, how DNA methylation clocks accurately measure biological age, and why boosting sirtuin activity improves resilience, neuroplasticity, and recovery. Dr. Guarente shares insider strategies from decades of functional medicine research, including nootropics, targeted supplements, fasting protocols, and diet adjustments from carnivore to Mediterranean that can shift your metabolism toward longevity. Dave and Dr. Guarente explore advanced biohacks like cold therapy, sleep optimization, and ketosis, plus how to balance these interventions with your genetics, lifestyle, and health goals. You'll also hear about the surprising role of homocysteine in brain aging, how to use lab testing to guide your longevity plan, and why resilience is the ultimate measure of health. You'll learn: • How emotional repression affects brain function, metabolism, and decision-making • Tools for nervous system regulation and emotional healing that drive high performance • Why most people fail without emotional intelligence and internal safety • How somatic awareness can optimize your energy, focus, and relationships • The science of fear, trauma release, and how to turn discomfort into growth • How to coach yourself out of stress, shame, and negative self-talk Whether you want to sharpen your brain, protect your heart, or upgrade your energy systems, this is a masterclass in smarter not harder biohacking for a longer, higher-performing life.Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday, Thursday, and Friday (audio-only) where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. Keywords: NAD+ supplementation, Sirtuin activation, DNA methylation clocks, Biological age testing, Mitochondrial biogenesis, Epigenetic reprogramming, Pterostilbene benefits, Nicotinamide riboside (NR), Nicotinamide mononucleotide (NMN), Homocysteine reduction, Oxidative stress repair, Superoxide dismutase (SOD) activation, Functional medicine longevity, Healthspan optimization, Resveratrol bioavailability, Menopause mitochondrial support, Phenylbutyrate and protein folding, High-fat diet longevity studies, Neurodegenerative disease biohacking, INCHIANTI aging study Thank you to our sponsors! Screenfit | Get your at-home eye training program for 40% off using code DAVE https://www.screenfit.com/dave. Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order. Resources: • Elysium Website. Use code ‘UPGRADE25' for 25% off the first month of a monthly subscription to any Elysium supplement: https://www.elysiumhealth.com/ • Dave Asprey's Website: https://daveasprey.com • Danger Coffee: https://dangercoffee.com/DAVE15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Introduction to NAD & Sirtuins 0:59 — Intro 7:04 — Animal vs Human Aging Studies 10:07 — Discovery of Sirtuins 14:43 — NAD's Role in Aging 15:34 — Resveratrol vs Pterostilbene 23:13 — Timing NAD Supplementation 36:34 — Diet & Lifestyle Factors 50:05 — Elysium's Basis & Signal 1:00:03 — Future Clinical Trials 1:05:14 — Psychology of Aging & Wrap-Up See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.