Podcasts about epigenetic

In this episode of the Epigenetics Podcast, we talked with Petra Hajkova from the MRC Laboratory of Medical Sciences about her work on epigenetics research on mammalian development, highlighting DNA methylation, histone modifications, and TET enzymes, along with her journey in molecular genetics and future research on epigenetic maintenance. Dr. Hajkova's early work focused on DNA methylation and resulted in innovative collaboration that allowed her to develop bisulfide sequencing techniques. We discuss her transition to the UK, where she began working in Azim Surani's lab at the University of Cambridge. Dr. Hajkova describes the excitement of researching chromatin dynamics in the mouse germline, leading to significant findings published in Nature. Her story highlights the intense yet rewarding nature of postdoctoral research as she navigated the complexities of working with embryos for the first time. As her research progressed, Dr. Hajkova established her own lab at the MRC London Institute of Medical Sciences, where she became a professor in 2017. We delve into her investigations on the differences between embryonic stem cells and embryonic germ cells regarding their distinct developmental origins. Dr. Hajkova outlines the challenges she faced in understanding the mechanisms behind global DNA demethylation in germline cells and the role of hydroxymethylation during early development. The discussion further covers her exciting findings regarding the specific functions of TET enzymes and their regulatory roles in maintaining epigenetic states. We explore her recent research published in Nature, which provides insights into the transition from primordial germ cells to gonocytes, emphasizing the significance of various epigenetic mechanisms in germline development.   References Hajkova P, Ancelin K, Waldmann T, Lacoste N, Lange UC, Cesari F, Lee C, Almouzni G, Schneider R, Surani MA. Chromatin dynamics during epigenetic reprogramming in the mouse germ line. Nature. 2008 Apr 17;452(7189):877-81. doi: 10.1038/nature06714. Epub 2008 Mar 19. PMID: 18354397; PMCID: PMC3847605. Hajkova P, Jeffries SJ, Lee C, Miller N, Jackson SP, Surani MA. Genome-wide reprogramming in the mouse germ line entails the base excision repair pathway. Science. 2010 Jul 2;329(5987):78-82. doi: 10.1126/science.1187945. PMID: 20595612; PMCID: PMC3863715. Hill PWS, Leitch HG, Requena CE, Sun Z, Amouroux R, Roman-Trufero M, Borkowska M, Terragni J, Vaisvila R, Linnett S, Bagci H, Dharmalingham G, Haberle V, Lenhard B, Zheng Y, Pradhan S, Hajkova P. Epigenetic reprogramming enables the transition from primordial germ cell to gonocyte. Nature. 2018 Mar 15;555(7696):392-396. doi: 10.1038/nature25964. Epub 2018 Mar 7. PMID: 29513657; PMCID: PMC5856367. Huang TC, Wang YF, Vazquez-Ferrer E, Theofel I, Requena CE, Hanna CW, Kelsey G, Hajkova P. Sex-specific chromatin remodelling safeguards transcription in germ cells. Nature. 2021 Dec;600(7890):737-742. doi: 10.1038/s41586-021-04208-5. Epub 2021 Dec 8. PMID: 34880491.   Related Episodes Epigenetic Mechanisms of Mammalian Germ Cell Development (Mitinori Saitou) Epigenetic Reprogramming During Mammalian Development (Wolf Reik) DNA Methylation and Mammalian Development (Déborah Bourc'his)   Contact Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com

Michael Ringel is the Chief Operating Officer of Life Biosciences, a biotechnology company pioneering cellular rejuvenation therapies to reverse and prevent multiple diseases of aging. Michael became COO of Life just a few months ago, but he's been advising the company since 2018. Prior to this year, he was managing director and senior partner at Boston Consulting Group (BCG), where over a 25-year career he focused on R&D and innovation initiatives across the private sector and government. He earned his PhD in biology at Imperial College London and a JD from Harvard Law, and has become an active and highly respected member of the global longevity biotech community.In this episode, Chris and Michael explore Life Biosciences' groundbreaking approach to partial epigenetic reprogramming - the "holy grail" technology that could transform how we age at cellular, tissue, and organism levels. They discuss how this approach taps into the same biology that makes babies young, Life's lead therapeutic candidate ER-100 for eye diseases, and the "pipeline in a pill" concept at the core of the geroscience hypothesis: the idea that enable single interventions based on longevity science could treat multiple age-related diseases simultaneously.The Finer Details:The biology behind partial epigenetic reprogramming and how it differs from full reprogramming to pluripotencyWhy Michael considers partial reprogramming the "holy grail" of longevity interventionsLife Biosciences' lead candidate ER-100 for glaucoma and NAION (non-arteritic anterior ischemic optic neuropathy)The innovative inducible system that allows the therapy to be turned on and off with doxycyclineWhy the eye represents an ideal starting point for reprogramming therapiesThe "pipeline in a pill" concept and geroscience hypothesis - how single interventions could treat multiple age-related diseasesParallels between the emerging longevity field and the massive GLP-1 drug market that many pharma companies missedThe role of philanthropic investment in advancing fundamental longevity researchEvolutionary theories of aging and why aging should be easily manipulableTimeline expectations for moving from single disease treatments to whole-body rejuvenationLinksLife Biosciences company websiteMichael Ringel's ARDD talk

OsteoBites welcomes Yingqi Hua, MD from Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine to discuss his work on molecular subtyping of osteosarcoma, ecDNA, and more.Dr. Hua has been engaged in basic and clinical research of malignant bone tumors for more than 10 years, focusing on the individualized comprehensive treatment of advanced bone tumors, and is committed to transforming research results through clinical research. His research interests include 1. Multi-omics study of osteosarcoma: Multi-omics analysis identifies osteosarcoma subtypes with distinct prognosis indicating stratified treatment. 2. Epigenetic study of bone tumors: the function of histone mutation and the function of different histone methylation modification. 3. Drug screen: Screening sensitive drugs by patient derived xenograft(PDX) and explore the mechanism of drug action. 4. Clinical trial of advanced stage sarcomas based on precision medicine.

In this episode of the Epigenetics Podcast, we talked with Ani Deshpande from Sanford Burnham Prebys about his work on epigenetic regulation and developing small molecules through high throughput screens for AML. Throughout our discussion, we delve into Dr. Despande's journey into the field of biology and science, tracing his evolution from a literature enthusiast in Mumbai to a dedicated cancer researcher. He reflects on his formative experiences during his PhD at Ludwig Maximilian University in Munich, where she developed murine models for refractory acute myeloid leukemia (AML). We examine these models' contributions to therapeutic discovery and understanding the intricate mechanisms underscoring AML's complexities. Transitioning to his postdoctoral work at Scott Armstrong's lab in Boston, Dr. Despande shares his insights on the importance of epigenetic regulators, such as DOT1L, in leukemias, and how they can serve as strategic therapeutic targets. His ambitious pursuit of translational research is further highlighted through his efforts in developing a conditional knockout mouse model and his collaborative work utilizing CRISPR technology to refine our understanding of epigenetic regulation in cancer pathogenesis. Moreover, we engage in a conversation about the challenges and opportunities that arise when establishing his lab at Sanford Burnham Prebys. Dr. Despande candidly discusses the delicate balance between pursuing topics of genuine interest versus adhering to grant fundability, underlining the tension researchers face in the current scientific landscape. His emphasis on the critical need for innovation within lab settings serves as a motivational call for emerging scientists to venture beyond the established templates that often inhibit groundbreaking discoveries. We conclude our dialogue with an exploration of his recent projects, which involve targeting specific epigenetic modifiers and how his lab's findings can contribute to greater understanding and potential treatments for not only AML but also other pediatric cancers driven by gene fusions. Dr. Despande's insights into the integration of modern technologies, such as CRISPR libraries, exemplify his commitment to pushing the boundaries of cancer research. In addition to discussing his scientific contributions, we touch upon Dr. Despande's foray into podcasting (The Discovery Dialogues), shedding light on his motivation to bridge the communication gap between scientists and the broader public. He articulates his desire to demystify scientific discoveries and promote awareness about the intricate journey of research that lays the groundwork for medical advancements. This multidimensional discussion not only highlights his scientific achievements but also emphasizes the importance of effective science communication in fostering public understanding and appreciation of research.   References Deshpande AJ, Cusan M, Rawat VP, Reuter H, Krause A, Pott C, Quintanilla-Martinez L, Kakadia P, Kuchenbauer F, Ahmed F, Delabesse E, Hahn M, Lichter P, Kneba M, Hiddemann W, Macintyre E, Mecucci C, Ludwig WD, Humphries RK, Bohlander SK, Feuring-Buske M, Buske C. Acute myeloid leukemia is propagated by a leukemic stem cell with lymphoid characteristics in a mouse model of CALM/AF10-positive leukemia. Cancer Cell. 2006 Nov;10(5):363-74. doi: 10.1016/j.ccr.2006.08.023. PMID: 17097559. Deshpande AJ, Deshpande A, Sinha AU, Chen L, Chang J, Cihan A, Fazio M, Chen CW, Zhu N, Koche R, Dzhekieva L, Ibáñez G, Dias S, Banka D, Krivtsov A, Luo M, Roeder RG, Bradner JE, Bernt KM, Armstrong SA. AF10 regulates progressive H3K79 methylation and HOX gene expression in diverse AML subtypes. Cancer Cell. 2014 Dec 8;26(6):896-908. doi: 10.1016/j.ccell.2014.10.009. Epub 2014 Nov 20. PMID: 25464900; PMCID: PMC4291116. Sinha S, Barbosa K, Cheng K, Leiserson MDM, Jain P, Deshpande A, Wilson DM 3rd, Ryan BM, Luo J, Ronai ZA, Lee JS, Deshpande AJ, Ruppin E. A systematic genome-wide mapping of oncogenic mutation selection during CRISPR-Cas9 genome editing. Nat Commun. 2021 Nov 11;12(1):6512. doi: 10.1038/s41467-021-26788-6. Erratum in: Nat Commun. 2022 May 16;13(1):2828. doi: 10.1038/s41467-022-30475-5. PMID: 34764240; PMCID: PMC8586238.   Related Episodes Targeting COMPASS to Cure Childhood Leukemia (Ali Shilatifard) The Menin-MLL Complex and Small Molecule Inhibitors (Yadira Soto-Feliciano) MLL Proteins in Mixed-Lineage Leukemia (Yali Dou)   Contact Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com

BUFFALO, NY — May 20, 2025 — A new #research paper was #published in Aging (Aging-US) Volume 17, Issue 4, on April 17, 2025, titled “Dietary associations with reduced epigenetic age: a secondary data analysis of the methylation diet and lifestyle study.” In this study, researchers led by first author Jamie L. Villanueva from the University of Washington and the National University of Natural Medicine, along with corresponding author Ryan Bradley from the National University of Natural Medicine and University of California, investigated how diet influences epigenetic aging. They found that certain plant-based foods containing natural compounds called methyl adaptogens were associated with a decrease in epigenetic age. This effect was measured using DNA methylation, a marker that reflects how the body ages at the cellular level. The findings suggest that targeted food choices may help slow the aging process. Epigenetic age refers to how old a person's cells appear biologically, rather than their actual age in years. DNA methylation patterns, which are chemical tags on DNA, can indicate whether someone is aging faster or slower than expected. For this study, researchers used Horvath's epigenetic clock, a widely accepted tool, to measure changes in epigenetic age. The analysis included healthy men aged 50 to 72 who had previously completed an eight-week program featuring a plant-based, nutrient-rich diet, along with guidance on exercise, sleep, and stress management. Researchers focused on individual dietary differences to understand why some participants experienced greater improvements in epigenetic age than others. The study found that those who ate higher amounts of methyl adaptogen foods—including turmeric, rosemary, garlic, berries, green tea, and oolong tea—experienced greater reductions in epigenetic age. These benefits remained significant even after accounting for weight changes and participants' starting epigenetic age, suggesting that the foods themselves had a direct impact on aging markers. “In hierarchical linear regression, foods investigated as polyphenolic modulators of DNA methylation (green tea, oolong tea, turmeric, rosemary, garlic, berries) categorized in the original study as methyl adaptogens showed significant linear associations with epigenetic age change (B = -1.21, CI = [-2.80, -0.08]), after controlling for baseline epigenetic age acceleration and weight changes.” The natural compounds in methyl adaptogen foods are known to influence how genes behave by affecting DNA methylation. Previous studies have shown that these compounds may support healthy aging and help lower the risk of conditions such as heart disease and cognitive decline. While this study involved a relatively small group of middle-aged men, it adds knowledge to growing global research showing that diets rich in polyphenols—found in vegetables, fruits, and teas—are associated with slower aging. These findings support earlier results from studies on Mediterranean and traditional Japanese diets, both known for their health benefits. Future research should include larger and more diverse populations and use updated epigenetic aging tools to confirm these results. Based on current evidence, this study highlights a practical, food-based strategy that may help reduce epigenetic aging and support long-term health. DOI - https://doi.org/10.18632/aging.206240 Corresponding author - Ryan Bradley - rbradley@nunm.edu To learn more about the journal, connect with us on social media at: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Exposure to inorganic arsenic before conception can trigger changes in gene activity that are passed down to offspring and increase their risk of developing diabetes, according to a study in mice funded by an NIEHS individual research grant and by the NIEHS Superfund Research Program. These changes, known as epigenetic changes, alter how genes work without changing the genes themselves. In this study, the researchers looked at a type of change called CpG methylation.

In this episode Dr. Raffaele Teperino shares insights from his ongoing research focused on developmental programming, particularly how paternal health before conception influences not only offspring health but also maternal health outcomes. As we trace his academic journey from studying biotechnology and pharmacology to leading his own lab, Dr. Teperino reflects on his early fascination with medicine, the pivotal experiences that shaped his career, and the integration of epigenetics into understanding metabolic diseases. We discuss the nuances of epigenetics—going beyond simple chromatin biology to examine its wider implications on phenotypic variation. Dr. Teperino emphasizes his approach of modeling relevant physiological phenomena in the lab to better understand the underlying mechanisms driving conditions like obesity and metabolic disruption. A particular focus is placed on his experiences during his postdoctoral years, where he investigated the developmental pathways of hedgehog signaling and its metabolic implications in adipogenesis. Our talk shifts towards the practical implications of his research, highlighting recent investigations into how circadian rhythms and paternal lifestyles influence offspring health. Dr. Teperino reveals his findings on how disturbances in circadian rhythms can lead to intergenerational health issues, showcasing the surprising effects observed in offspring of fathers experiencing circadian misalignment. We delve into the significance of seminal fluid as a potential medium for intergenerational transfer of stress responses, examining the role of stress hormones and their impacts on fetal development. As we explore a fascinating recent study highlighting the impact of paternal diets on future generations, Dr. Teperino underscores the importance of understanding the shorter exposure periods sufficient to trigger these health changes. He presents data that links paternal obesity and preconception health to an increased risk of obesity and insulin resistance in children, challenging traditional narratives around maternal responsibility for offspring health.   References Darr J, Tomar A, Lassi M, Gerlini R, Berti L, Hering A, Scheid F, Hrabě de Angelis M, Witting M, Teperino R. iTAG-RNA Isolates Cell-Specific Transcriptional Responses to Environmental Stimuli and Identifies an RNA-Based Endocrine Axis. Cell Rep. 2020 Mar 3;30(9):3183-3194.e4. doi: 10.1016/j.celrep.2020.02.020. PMID: 32130917. Lassi M, Tomar A, Comas-Armangué G, Vogtmann R, Dijkstra DJ, Corujo D, Gerlini R, Darr J, Scheid F, Rozman J, Aguilar-Pimentel A, Koren O, Buschbeck M, Fuchs H, Marschall S, Gailus-Durner V, Hrabe de Angelis M, Plösch T, Gellhaus A, Teperino R. Disruption of paternal circadian rhythm affects metabolic health in male offspring via nongerm cell factors. Sci Adv. 2021 May 26;7(22):eabg6424. doi: 10.1126/sciadv.abg6424. PMID: 34039610; PMCID: PMC8153725. Tomar A, Gomez-Velazquez M, Gerlini R, Comas-Armangué G, Makharadze L, Kolbe T, Boersma A, Dahlhoff M, Burgstaller JP, Lassi M, Darr J, Toppari J, Virtanen H, Kühnapfel A, Scholz M, Landgraf K, Kiess W, Vogel M, Gailus-Durner V, Fuchs H, Marschall S, Hrabě de Angelis M, Kotaja N, Körner A, Teperino R. Epigenetic inheritance of diet-induced and sperm-borne mitochondrial RNAs. Nature. 2024 Jun;630(8017):720-727. doi: 10.1038/s41586-024-07472-3. Epub 2024 Jun 5. PMID: 38839949; PMCID: PMC11186758.   Related Episodes The Impact of Paternal Diet on Offspring Metabolism (Upasna Sharma) Transgenerational Inheritance and Evolution of Epimutations (Peter Sarkies) The Role of Small RNAs in Transgenerational Inheritance in C. elegans (Oded Rechavi)   Contact Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com

Too busy to read the Lens? Listen to our weekly summary here! In this week's issue we discuss:Epigenetic aging alone, as established by DNA methylation studies, correlates with faster glaucoma progression independent of IOP. Repeated low-level red light (RLRL) therapy can delay myopia progression and axial elongation in children, but new research shows it can lead to ganglion cell damage and cone photoreceptor loss.Pegcetocoplan treatment reduces vision loss in the fovea and junctional zone in patients with geographic atrophy, per microperimetry analysis.

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referencesCureus. 2023 Nov27;15(11):e49521Cell Reports Medicine 2024 V5, Issue 91017 28 September 17, Nature Communications | (2022) 13:6781Cancer Cell. 2020 Jul 9;38(2):167–197.Am J Physiol Endocrinol Metab.2013 Feb 12;304(8):E789–E799.Hunter/Garcia et al.1975. "Blues for Allah" lp. Grateful Dead.https://open.spotify.com/album/5BwjVdVJ4aOmbIYomznfCv?si=1k4STRnoR4SAxG3DVrO0IAHaydn, M. "Requiem in C Minorhttps://open.spotify.com/album/0lr5buO8BDuJGQhBeTgzfR?si=HLCnU3JBSKu596rKZ96eiQ

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ReferencesCell Death Discov . 2023 Dec 12; 9:451JBC 2025.in Press 10854 . 4AprilActa Pharm Sin B. 2022 Dec;12(12):4390-4406https://www.genecards.org/cgi-bin/carddisp.pl?gene=NAT10Lamm, R. 1972 Dialogues 1&2 Chicago V.https://open.spotify.com/track/6FYcpCjvjTFlKRSSmh13lX?si=04550ed93c724d46Anderson, I. 1972. "Thick as a Brick pt 1. "https://open.spotify.com/track/0eufeeCADKlpxLA7HATWBW?si=23c1fd6f96984c15Schubert, F. 1816;1822. Symphonies 5&8https://open.spotify.com/album/60ozSapXWEc6PZWDh3tllN?si=orEE14UOQvmsDWYYtljvSA

ReferencesJournal of Biological Chemistry 2013. 28.8 52 :37355-37364 Neuro Oncol . 2020 Mar5;22(3):333-344.Front. Cell. Neurosci., 2018 27 NovemberCell Metabolism 2016. Volume 23, Issue 2, Pages 303-314JBC in Press 2025. 10854. 4April. Mydland, B. 1989. "I will Take You Home" Grateful Deadhttps://open.spotify.com/track/1Q3AmIjEbPYemA6UkjUUu0?si=3301b3057df94e04Joel, B. 1979. "Until the Night"https://open.spotify.com/track/3UzWjLQVzCG60gwJdApLqI?si=c0a9ded856c941cdSimon, P. 1965. "April Come She Will"https://open.spotify.com/track/0djZ2ndRfAL69WYNra5jRC?si=da8581de131448b2Mozart, WA. 1787. et al. Symphony 25 K.183 in G minor , plus symphonies 28, and 29https://open.spotify.com/album/3qhUJTpkFjDeM49QidGMQb?si=iUpvUWNfSlyWGSzgvjDKLg

In this episode of the Epigenetics Podcast, we talked with Dr. Frank Johannes from the Technical University of Munich in Freising about his work on evolutionary clocks and epigenetic inheritance in plants. In this episode we discuss Dr. Johannes pursuits in understanding how heritable epigenetic variations, particularly through DNA methylation, affect phenotypic diversity in plants. He shared insights about groundbreaking research initiatives he has led, including one of the first population epigenetic studies in plants that effectively linked heritable DNA methylation changes to critical traits like flowering time and root length. This work underscored the importance of epigenetic factors that extend beyond traditional genetic sequences, illustrating a significant shift in how we comprehend inheritance and trait variation in organisms. As we dug deeper into the science, we examined Dr. Johannes's innovative approaches to studying chromatin-based mechanisms of genome regulation, allowing for a nuanced understanding of epigenetic inheritance. His lab's extensive phenotyping of Arabidopsis plants highlighted how inducing heritable variations in DNA methylation could lead to significant trait outcomes – results that have substantial implications for agriculture and understanding complex characteristics across generations. The dialogue continued to unravel the dynamics between forward and backward epimutations, delving into their heritable nature and their rapid accumulation compared to traditional genetic mutations. Dr. Johannes overturned conventional understanding by presenting epigenetic processes that are not as static as once thought, providing compelling evidence that these spontaneous changes could inform evolutionary clocks; a concept that offers new avenues for studying the relationships between species over relatively short timeframes. Moreover, we discussed the exciting concept of epigenetic clocks, which play a role in assessing the age of various species, including trees. The potential applications for such clocks in environmental management and the assessment of tree vitality further illuminated the practical impacts of Dr. Johannes's research. These insights also pave the way for sophisticated non-invasive methods of understanding plant biology, which can revolutionize forest management practices in the face of climate change and other ecological pressures.   References Colomé-Tatché M, Cortijo S, Wardenaar R, Morgado L, Lahouze B, Sarazin A, Etcheverry M, Martin A, Feng S, Duvernois-Berthet E, Labadie K, Wincker P, Jacobsen SE, Jansen RC, Colot V, Johannes F. Features of the Arabidopsis recombination landscape resulting from the combined loss of sequence variation and DNA methylation. Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16240-5. doi: 10.1073/pnas.1212955109. Epub 2012 Sep 17. PMID: 22988127; PMCID: PMC3479620. Cortijo S, Wardenaar R, Colomé-Tatché M, Gilly A, Etcheverry M, Labadie K, Caillieux E, Hospital F, Aury JM, Wincker P, Roudier F, Jansen RC, Colot V, Johannes F. Mapping the epigenetic basis of complex traits. Science. 2014 Mar 7;343(6175):1145-8. doi: 10.1126/science.1248127. Epub 2014 Feb 6. PMID: 24505129. van der Graaf A, Wardenaar R, Neumann DA, Taudt A, Shaw RG, Jansen RC, Schmitz RJ, Colomé-Tatché M, Johannes F. Rate, spectrum, and evolutionary dynamics of spontaneous epimutations. Proc Natl Acad Sci U S A. 2015 May 26;112(21):6676-81. doi: 10.1073/pnas.1424254112. Epub 2015 May 11. PMID: 25964364; PMCID: PMC4450394. Yao N, Zhang Z, Yu L, Hazarika R, Yu C, Jang H, Smith LM, Ton J, Liu L, Stachowicz JJ, Reusch TBH, Schmitz RJ, Johannes F. An evolutionary epigenetic clock in plants. Science. 2023 Sep 29;381(6665):1440-1445. doi: 10.1126/science.adh9443. Epub 2023 Sep 28. PMID: 37769069.   Related Episodes Transgenerational Inheritance and Epigenetic Imprinting in Plants (Mary Gehring) Epigenetic Clocks and Biomarkers of Ageing (Morgan Levine)   Contact Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com

BUFFALO, NY — April 23, 2025 — A new #research paper was #published in Aging (Aging-US) Volume 17, Issue 3, on March 18, 2025, titled “Epigenetic and accelerated age in captive olive baboons (Papio anubis), and relationships with walking speed and fine motor performance.” In this study, led by Sarah J. Neal from The University of Texas MD Anderson Cancer Center, researchers examined how the epigenetic age of baboons—a measure of biological aging based on DNA methylation—compared to their actual age (chronological age) and whether it related to signs of aging like slower walking or reduced hand coordination. While many baboons showed a mismatch between their epigenetic and chronological ages, these differences did not consistently align with physical performance measures. Researchers analyzed blood samples from 140 captive olive baboons (Papio anubis) to determine whether these primates, like humans, show signs of “age acceleration”—a condition where epigenetic age surpasses chronological age. The results revealed that about a quarter of the baboons exhibited accelerated aging, while another quarter showed signs of slower aging, known as “age deceleration.” “We found that epigenetic age was strongly correlated with chronological age, and that approximately 27% of the sample showed age acceleration and 28% showed age deceleration." The scientists then investigated whether these differences were reflected in physical indicators such as walking speed or fine motor skills. To do this, researchers measured walking speed by tracking how quickly baboons moved between points in their enclosures and assessed fine motor skills using a simple task that involved picking up small objects. Older baboons did tend to walk more slowly and perform worse on tasks requiring dexterity, patterns also seen in aging humans. However, these changes were more closely related to chronological age than epigenetic age. Two different methods were used to measure the gap between epigenetic and chronological age. Each method produced slightly different outcomes, highlighting the complexity of defining age acceleration. In one analysis, the oldest baboons appeared to age more slowly epigenetically, possibly reflecting selective survival, where only the healthiest individuals live into old age. This research is among the first to classify baboons based on their epigenetic aging rate and investigate how this links to real-world signs of aging. Although the findings did not provide clear evidence that epigenetic age acceleration leads to physical decline, they point to the importance of DNA methylation as a biomarker in aging research. Because baboons share many biological similarities with humans, these findings help refine how researchers measure aging and assess potential early warning signs of decline. Continued studies in baboons and other primates may improve our understanding of how epigenetic aging influences health and longevity—and could help develop better tools for predicting age-related decline in humans. DOI - https://doi.org/10.18632/aging.206223 Corresponding author - Sarah Neal - SJNeal@MDAnderson.org Video short - https://www.youtube.com/watch?v=EFfRMFbAMqk Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206223 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts To learn more about the journal, please visit our website at https://www.Aging-US.com​​ and connect with us on social media at: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

What if aging isn't just inevitable—but modifiable? In this episode of Longevity Roadmap, Dr. Matt Kaeberlein breaks down the science of biological aging, with a focus on mTOR, epigenetics, and the hallmarks of aging like cellular senescence, mitochondrial dysfunction, and epigenetic drift. He explores the role of genetics vs. environment, the promise and pitfalls of metformin, NAD boosters, and senolytics, and why interventions like rapamycin and caloric restriction may extend health span. From the limitations of biological age tests to the importance of lean muscle mass, this conversation is a masterclass in evidence-based longevity research. Watch the full episode to understand the mechanisms of aging—and what current science says about slowing them down. Learn more about Dr. Matt Kaeberlein and Optisan: https://www.optispan.life/ - Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0 Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com/

In this thought-provoking episode of Keeping Abreast, I sit down with Dr. Nathan Goodyear, a board-certified physician who left conventional oncology to become a pioneer in integrative cancer care. Together, they explore the limitations of traditional treatment models and why the current “war on cancer” mentality may be doing more harm than good.Dr. Goodyear opens up about his personal journey from a traditional medical background to becoming a patient himself—an experience that radically changed his approach to healing. He and Dr. Jenn unpack the deeper truths about cancer: its roots in immune dysfunction, the influence of lifestyle and environment, and the transformative power of epigenetics.This episode doesn't shy away from controversy—from the politicization of medicine to the potential of off-label and repurposed drugs like ivermectin and metformin. It's a bold, necessary conversation about empowering patients, reimagining cancer care, and building a future where treatment is rooted in innovation, integrity, and true healing.In This Episode, You Will Learn:Dr. Goodyear's personal health crisis inspired a complete shift in his approach to cancer care.The “fight” against cancer often becomes a fight against the body—integrative medicine aims to heal, not battle.Cancer is part of the immune system—understanding that changes everything.Cryoablation offers a powerful, less invasive alternative to surgery with promising outcomes.Lifestyle, stress, diet, and toxins play a critical role in cancer development and recurrence.Epigenetic changes can pass through generations, altering cancer risk.Mammograms may not be as protective as once believed—and may lead to overtreatment.The healthcare system often incentivizes drugs over real healing.Repurposed medications like metformin and ivermectin show powerful anti-cancer potential.The term “quack” is weaponized to discredit innovative doctors who challenge the norm.

In this episode, I'm joined by the brilliant Dr. Piper Gibson, and let me tell you, this conversation is packed with insight, truth bombs, and hope for anyone dealing with chronic health issues that feel confusing, overwhelming, or unsolvable.Dr. Gibson is an epigenetics expert, a functional medicine practitioner, and the founder of Elite Gene Labs and the Tic Disorder Institute. She brings years of experience working with families, especially those navigating tic disorders, anxiety, ADHD, autoimmune symptoms, and chronic inflammation. We dive into how our genetics and environment interact, how symptoms are often signals (not life sentences), and what's actually possible when we start asking better questions.We talk about:Why so many kids are being dismissed with “they'll grow out of it” and why that's not good enoughWhat tic disorders really are and how to decode themThe critical role inflammation and gut health play in anxiety, ADHD, and other neurological symptomsWhy genomic testing matters, how it works, and what it can actually tell youThe myth of “one-size-fits-all” health and how personalization changes everythingHow Dr. Piper's own son's health crisis led her to this work, and what she's learned from helping hundreds of families sinceIf you've ever felt dismissed by the system, overwhelmed by information online, or unsure of where to start, this episode is for you. Dr. Piper and I are both passionate about helping you feel seen, heard, and empowered to take control of your health in a real, personalized way.You are not broken. Your body is trying to talk to you. Let's start listening together.Learn more about Piper Gibson:Dr. Gibson founded the Tic Disorder Institute: Regenerating Health and Elite Gene Labs, where she empowers families and healthcare professionals to address tic disorders and optimize wellness. She is a Doctor of Functional Medicine, Advanced Holistic Nutrition, and a Board-Certified Doctor of Natural Medicine.Dr. Gibson helps individuals address the root of their symptoms through functional lab testing, nutrition, and genetic insights. She is also the author of Tic Talk: Common Misconceptions, Natural Approaches, and Real Conversations about Tic Disorders.RESOURCES:Connect with Piper Gibson:Facebook: https://www.facebook.com/RegeneratingHealthInstagram: https://www.instagram.com/regeneratinghealth/YouTube: https://www.youtube.com/@ticdisordersecretsShow Links:Visit the website: healthyawakening.co/podcastFind listening links here: https://healthyawakening.co/linksSHOW NOTES:healthyawakening.co/episode51Connect with Susan:Contact me for your DNA testing or epigenetic coaching!To schedule a FREE consultation, send an email to susan@healthyawakening.coFaceboook: https://www.facebook.com/susanP.S. Want reminders about episodes? Sign up for our newsletter, you can find the link on our podcast page! https://healthyawakening.co/podcast

Parent-specific epigenetic marks (imprints) leading to parent-specific gene expression are crucial for normal growth and development, yet their mechanisms of establishment and maintenance are not fully understood. In humans, approximately 200 imprinted genes have been discovered, and improper imprinting can manifest in growth restriction, obesity, intellectual disabilities, behavioral abnormalities, and an increased risk of certain cancers. While the use of pluripotent stem cells, especially those in the naïve state, have advanced aspects of modeling early development, a persistent issue hampering bona fide naïve hPSCs is the erosion of imprints. Our guests on today's episode will discuss genomic imprinting, its function, impact, and a new reporter system of imprinted gene expression in hPSCs that enables real-time visualization of loss-of-imprinting at single-cell resolution. This assay provides an important tool to help discover how to improve the imprint fidelity of naïve hPSCs and hence their application for studies of human development and regeneration. Guests Thorold Theunissen, PhD, Department of Developmental Biology, Washington University in St Louis, USA Gal Keshet, The Azrieli Center for Stem Cells and Genetic Research, The Hebrew University of Jerusalem, IsraelSupporting ContentTracking and mitigating imprint erasure during induction of naïve human pluripotency at single-cell resolutionHostJanet Rossant, Editor-in-Chief, Stem Cell Reports and The Gairdner FoundationAbout Stem Cell ReportsStem Cell Reports is the open access, peer-reviewed journal of the International Society for Stem Cell Research (ISSCR) for communicating basic discoveries in stem cell research, in addition to translational and clinical studies. Stem Cell Reports focuses on original research with conceptual or practical advances that are of broad interest to stem cell biologists and clinicians.X: @StemCellReportsAbout ISSCRWith nearly 5,000 members from more than 80 countries, the International Society for Stem Cell Research (@ISSCR) is the preeminent global, cross-disciplinary, science-based organization dedicated to stem cell research and its translation to the clinic. The ISSCR mission is to promote excellence in stem cell science and applications to human health.ISSCR StaffKeith Alm, Chief Executive OfficerYvonne Fisher, Managing Editor, Stem Cell ReportsKym Kilbourne, Director of Media and Strategic CommunicationsMegan Koch, Senior Marketing ManagerJack Mosher, Scientific AdvisorHunter Reed, Senior Marketing CoordinatorVoice WorkBen Snitkoff

Lesbians take on the United Nations https://blogs.lse.ac.uk/lsehistory/2025/02/26/lesbians-take-on-the-united-nations/https://www.troubleandstrife.org/articles/issue-33/lesbians-take-on-the-un/Memories of the 1996 International Conference on Violence, Abuse & Women's Citizenship https://brighton96.filia.org.uk/Gen Z need to drink more to save lesbian bars https://www.lgbtqnation.com/2025/03/gen-zers-dont-know-how-to-go-to-bars-are-lesbian-bars-in-danger/18 lesbian sports power couples who are winning at life and lovehttps://sports.yahoo.com/article/18-lesbian-sports-power-couples-203743549.htmlWould you do this? https://www.thecollegefix.com/gene-edit-lesbians-eggs-to-mimic-sperm-medical-journal-argues/ This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.thelesbianprojectpod.com/subscribe

歡迎嚟到 搞乜咁科學 GMG Science 第33集！今集嘅主題係《一個人生B與叻過ChatGPT Baby Making DIY & Human Outsmarting AI》

This week, Jonathan is joined by Eytan Stein, Chief of the Leukaemia Service and an Attending Physician at Memorial Sloan Kettering Cancer Center, New York, USA.  Timestamps:      (00:00)-Introduction  (01:05)-The current landscape of treatments  (02:26)-The promise and peril of differentiation therapy  (05:55)-Highlighting the most impactful clinical trials  (08:38)-Epigenetics and the future of targeted therapies  (10:40)-The BEAT AML master clinical trial  (12:57)-The latest research into IDH inhibitors  (16:10)-Therapies for splicing factor mutations  (19:29)-Reducing patient fear with education   (22:46)-Stein's three wishes for healthcare   

Dr. Moshe Szyf from EpiMedTech Global in Singapore discusses a research paper he co-authored that was published in Volume 17, Issue 1 of Aging (Aging-US), entitled “EpiAge: a next-generation sequencing-based ELOVL2 epigenetic clock for biological age assessment in saliva and blood across health and disease.” DOI - https://doi.org/10.18632/aging.206188 Corresponding author - Moshe Szyf - moshe.szyf@epimedtech.com Video interview - https://www.youtube.com/watch?v=NA8Vctks0gY Video transcript - https://www.aging-us.com/interviews/epiage-ngs-based-elovl2-epigenetic-clock-for-biological-age-assessment Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206188 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, epigenetic clock, elovl2, next-generation sequencing, EpiAge, Alzheimer's disease About Aging-US The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population. The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.) Please visit our website at https://www.Aging-US.com​​ and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

The publication of this content was funded by Beiersdorf.* Tune into this Article Recap Join leading dermatologists and epigenetics researchers Frank Lyko, Firas Al-Niaimi, Hassan Galadari, Elke Grönniger, and Julia Gallinger in this insightful audio recap of an article exploring groundbreaking approaches to facial skin ageing. Highlights from a European Academy of Dermatology & Venereology (EADV) symposium shed light on the latest advancements in epigenetics in combination with innovative skincare interventions. The discussion covers: mechanisms of reversible DNA methylation changes in skin ageing and their potential for transformative treatments;  the skin-specific age clock, an AI-powered tool which measures biological skin age and supports the creation of Epicelline®, an active ingredient targeting DNA methylation to reverse clinical signs of ageing;  outcomes in laser therapies with additional use of Epicelline®; and  case studies on combining Epicelline® with aesthetic treatments such as chemical peels, microneedling, and injectables. *The following recording is an audio article sponsored and provided by Beiersdorf, and hosted on the EMJ Podcast: Insights for Healthcare Professionals. It is aimed at healthcare professionals and recaps the symposium review article entitled, ‘Reverse the Age Clock: Reverse Clinical Signs of Ageing with Epigenetic Skin Science', published in EMJ Dermatology 12.1 in November 2024. To access the full article, visit emjreviews.com. The content included is promotional and contains product placement, highlighting specific products or services, including paid partnerships or sponsorships. Please consult reliable resources or professional advice for any questions about the topics discussed. The opinions expressed do not necessarily represent the opinions of EMJ.

Want to influence your biological age? Today's #WisdomWednesday reveals how your lifestyle choices act as "bookmarks" in your genetic instruction manual, determining which genes get activated or silenced as you age. From strategic exercise timing to specific superfoods, discover science-backed strategies that can help reprogram your genes for healthier aging. Plus, learn why your social connections might be just as important as your workout routine in keeping your genes young. Have a listen today.See omnystudio.com/listener for privacy information.

In this episode of the Epigenetics Podcast, we talked with Ferdinand von Meyenn from ETH Zürich about his work on the interplay of nutrition, metabolic pathways, and epigenetic regulation. To start Dr. Meyenn recounts his pivotal research on DNA methylation in naive embryonic stem cells during his time with Wolf Reick. He explains the dynamics of global demethylation in naive stem cells, revealing the key enzymes involved and the unexpected findings surrounding UHF1—its role in maintaining DNA methylation levels and influencing the methylation landscape during early embryonic development. Dr. Meyenn then shares his perspective on the scientific transition to establishing his own lab at ETH. He reflects on his ambitions to merge the fields of metabolism and epigenetics, which is a recurring theme throughout his research. By investigating the interplay between metabolic changes and epigenetic regulation, he aims to uncover how environmental factors affect cellular dynamics across various tissues. This leads to a discussion of his recent findings on histone lactylation and its implications in cellular metabolism, as well as the intricacies of epigenetic imprinting in stem cell biology. Last but not least we touch upon Dr. Meyenn's most recent study, published in Nature, investigating the epigenetic effects of obesity. He provides a detailed overview of how adipose tissue undergoes transcriptional and epigenetic rearrangements during weight fluctuations. The conversation highlights the notion of epigenetic memory in adipocytes, showing how obesity is not just a temporary state but leaves lasting cellular changes that can predispose individuals to future weight regain after dieting. This exploration opens avenues for potential therapeutic interventions aimed at reversing adverse epigenetic modifications.   References von Meyenn, F., Iurlaro, M., Habibi, E., Liu, N. Q., Salehzadeh-Yazdi, A., Santos, F., Petrini, E., Milagre, I., Yu, M., Xie, Z., Kroeze, L. I., Nesterova, T. B., Jansen, J. H., Xie, H., He, C., Reik, W., & Stunnenberg, H. G. (2016). Impairment of DNA Methylation Maintenance Is the Main Cause of Global Demethylation in Naive Embryonic Stem Cells. Molecular cell, 62(6), 848–861. https://doi.org/10.1016/j.molcel.2016.04.025 Galle, E., Wong, C. W., Ghosh, A., Desgeorges, T., Melrose, K., Hinte, L. C., Castellano-Castillo, D., Engl, M., de Sousa, J. A., Ruiz-Ojeda, F. J., De Bock, K., Ruiz, J. R., & von Meyenn, F. (2022). H3K18 lactylation marks tissue-specific active enhancers. Genome biology, 23(1), 207. https://doi.org/10.1186/s13059-022-02775-y Agostinho de Sousa, J., Wong, C. W., Dunkel, I., Owens, T., Voigt, P., Hodgson, A., Baker, D., Schulz, E. G., Reik, W., Smith, A., Rostovskaya, M., & von Meyenn, F. (2023). Epigenetic dynamics during capacitation of naïve human pluripotent stem cells. Science advances, 9(39), eadg1936. https://doi.org/10.1126/sciadv.adg1936 Bonder, M. J., Clark, S. J., Krueger, F., Luo, S., Agostinho de Sousa, J., Hashtroud, A. M., Stubbs, T. M., Stark, A. K., Rulands, S., Stegle, O., Reik, W., & von Meyenn, F. (2024). scEpiAge: an age predictor highlighting single-cell ageing heterogeneity in mouse blood. Nature communications, 15(1), 7567. https://doi.org/10.1038/s41467-024-51833-5 Hinte, L. C., Castellano-Castillo, D., Ghosh, A., Melrose, K., Gasser, E., Noé, F., Massier, L., Dong, H., Sun, W., Hoffmann, A., Wolfrum, C., Rydén, M., Mejhert, N., Blüher, M., & von Meyenn, F. (2024). Adipose tissue retains an epigenetic memory of obesity after weight loss. Nature, 636(8042), 457–465. https://doi.org/10.1038/s41586-024-08165-7   Related Episodes Nutriepigenetics: The Effects of Diet on Behavior (Monica Dus) Epigenetic and Metabolic Regulation of Early Development (Jan Żylicz) Effects of Environmental Cues on the Epigenome and Longevity (Paul Shiels)   Contact Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com

BUFFALO, NY- January 20, 2025 – A new #research paper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) on December 5, 2024, Volume 16, Issue 22, titled “DNA-methylation age and accelerated epigenetic aging in blood as a tumor marker for predicting breast cancer susceptibility.” Researchers Su Yon Jung, Herbert Yu, Youping Deng, and Matteo Pellegrini from the University of California, Los Angeles and University of Hawaii Cancer Center have found that a simple blood test could help predict breast cancer (BC) risk in older women. Their study focuses on epigenetic aging, a process that reflects how fast the body's cells age based on DNA methylation changes (DNAm). Breast cancer is one of the most common cancers worldwide, with the risk increasing significantly after menopause. The researchers analyzed blood samples from postmenopausal, non-Hispanic white women. They discovered that those with an “older” biological age had a significantly higher risk of being diagnosed with breast cancer. The risk was even greater in women who had their ovaries removed before natural menopause, likely due to reduced estrogen levels, a hormone that plays a key role in aging and breast health. “Of note, in women with bilateral oophorectomy before natural menopause experiencing shorter lifetime estrogen exposure than those with natural menopause, epigenetic age accel substantially influenced BC development, independent of obesity status and exogeneous estrogen use.” The study also found that lifestyle factors influence epigenetic aging and breast cancer risk. Women with obesity experienced faster biological aging, which increased their risk of developing cancer. Meanwhile, hormone replacement therapy had varying effects depending on the type and duration of treatment. Early detection of breast cancer is crucial for effective treatment and survival. Traditional risk assessments—such as age, family history, and lifestyle habits—may not provide the full picture. This study suggests that adding a blood test to measure biological aging could help clinicians identify high-risk women earlier and offer personalized prevention strategies. With further research, this blood test could become a routine screening tool in women's health check-ups. It may empower women to take proactive steps to reduce their breast cancer risk through healthy lifestyle choices, including maintaining a balanced diet, staying physically active, and considering appropriate hormone therapies under medical supervision. In conclusion, further studies are needed to validate these findings and explore their applicability to a broader population of women. However, this research presents a promising, non-invasive, and cost-effective approach to predicting breast cancer risk. DOI - https://doi.org/10.18632/aging.206169 Corresponding author - Su Yon Jung - sjung@sonnet.ucla.edu Video short - https://www.youtube.com/watch?v=g1tHojirvI8 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts About Aging-US The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population. The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.) Please visit our website at https://www.Aging-US.com​​ and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Welcome back to A Stride Above! In today's episode, we're thrilled to introduce our guest, Fabien Hronec, who will be discussing the fascinating world of epigenetic testing. Fabien's journey into this innovative field began 11 years ago when he sought a deeper understanding of health and how to assess what's happening within our bodies.In this episode, you'll learn about:• The introduction of epigenetic scanning using hair follicles, which serve as durable markers for cellular activity over the past 90 days.• How this technology provides insights into your body's nutrient levels, acids, antioxidants, vitamins, minerals, and more—without the need for specific parameters like traditional bloodwork.• The integration of alternative medicine with traditional practices to optimize health, emphasizing the importance of addressing root causes rather than just symptoms.• Fabien's innovative approach of developing a supplement compounded from medical-grade ingredients to help horses achieve optimal health based on their specific deficiencies.If you want to dive deeper into the world of epigenetic testing or have any questions for Fabien, feel free to reach out through his social media channels or visit https://www.rebootselfcare.com/ for more information! Don't forget to subscribe, follow, and rate this podcast—we truly appreciate your support! Join us next week for more enlightening discussions and tips on enhancing the health and well-being of your horse.Links For You:• Our Website • Facebook • Instagram • Youtube Dr. Alberto Rullan, VMD• Website• LinkedIn• Instagram

References Guerra, DJ 2024. Biochemistry lectures de novo. Zevon, W. 1980. "Empty Handed Heart" https://open.spotify.com/track/2jqAdzGsLts2SPcDxNjqGJ?si=a3d0cf83804641c3 Manfred Mann [solo], Colin Pattenden, Peter Thomas .1976 "The Road to Babylon" https://open.spotify.com/track/7cUBAZwaFjPkdEkFMAGy7Y?si=210544d489544d29 Haydn, Michael. 1794. Excerpts from his Catholic Masses https://open.spotify.com/album/67v4gHJdnVWAn4erEtbuIc?si=3FHMYbRGQJaTHGbqYHHo8Q --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support

Do you know your biological age?

In this episode of the Epigenetics Podcast, we talked with Maxim Greenberg from the Institute Jacob Monot about his work on epigenetic consequences of DNA methylation in development. In this interview we explore how Dr. Greenbergs work at UCLA involved pioneering experiments on DNA methylation mechanisms and how this period was marked by significant collaborative efforts within a highly competitive yet supportive lab environment that ultimately lead to publications in high impact journals. His transition to a postdoctoral position at the Institut Curie with Deborah Bourc'his harnessed his newfound expertise in mammalian systems, examining chromatin changes and the implications for embryonic development. Dr. Greenberg explained the nuances of his research, particularly how chromatin modifications during early development can influence gene regulatory mechanisms later in life, providing a compelling narrative about the potential long-term impacts of epigenetic changes that occur in utero. Throughout our conversation, we examined the intricate relationship between DNA methylation and Polycomb repression, discussing how these epigenetic mechanisms interact and the functional outcomes of their regulation. Dr. Greenberg's insights into his recent studies reveal a commitment to unraveling the complexities of enhancer-promoter interactions in the context of epigenetic regulation.   References Greenberg, M. V., Ausin, I., Chan, S. W., Cokus, S. J., Cuperus, J. T., Feng, S., Law, J. A., Chu, C., Pellegrini, M., Carrington, J. C., & Jacobsen, S. E. (2011). Identification of genes required for de novo DNA methylation in Arabidopsis. Epigenetics, 6(3), 344–354. https://doi.org/10.4161/epi.6.3.14242 Greenberg, M. V., Glaser, J., Borsos, M., Marjou, F. E., Walter, M., Teissandier, A., & Bourc'his, D. (2017). Transient transcription in the early embryo sets an epigenetic state that programs postnatal growth. Nature genetics, 49(1), 110–118. https://doi.org/10.1038/ng.3718 Greenberg, M., Teissandier, A., Walter, M., Noordermeer, D., & Bourc'his, D. (2019). Dynamic enhancer partitioning instructs activation of a growth-related gene during exit from naïve pluripotency. eLife, 8, e44057. https://doi.org/10.7554/eLife.44057 Monteagudo-Sánchez, A., Richard Albert, J., Scarpa, M., Noordermeer, D., & Greenberg, M. V. C. (2024). The impact of the embryonic DNA methylation program on CTCF-mediated genome regulation. Nucleic acids research, 52(18), 10934–10950. https://doi.org/10.1093/nar/gkae724 Richard Albert, J., Urli, T., Monteagudo-Sánchez, A., Le Breton, A., Sultanova, A., David, A., Scarpa, M., Schulz, M., & Greenberg, M. V. C. (2024). DNA methylation shapes the Polycomb landscape during the exit from naive pluripotency. Nature structural & molecular biology, 10.1038/s41594-024-01405-4. Advance online publication. https://doi.org/10.1038/s41594-024-01405-4   Related Episodes DNA Methylation and Mammalian Development (Déborah Bourc'his) Circulating Epigenetic Biomarkers in Cancer (Charlotte Proudhon) Epigenetic Mechanisms in Genome Regulation and Developmental Programming (James Hackett)   Contact Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com

January is the peak season for divorce, depression, extreme autism and ADHD symptoms, anxiety and heaviness. Why? Because we show up with unhealed trauma-responses in December. That's what causes numbing out with food. That's what causes compulsive shopping and doormat-tendencies, hefty arguments and deep sadness when your child doesn't fit in, speak or behave and no one seems to help or understand you.You need rest for your body and soul during the holidays. I want to help you in this peaceful Holiday season podcast episode..You need rest for your body and soul during the holidays. You do NOT NEED what most people get in December:More expectations.More hyperactivity, meltdowns, tantrums and autism symptoms.More expenses.More trauma triggers.More stress and sadness.More sugar that weighs you down in January.More arguments with family members and dissapointment .More stuff.More food than your tired body can handle.In this podcast episode, Christian autism mom-coach Ninka-Bernadette Mauritson from Barefoot Autism warriors shares the best tools for a peaceful Holiday.Spiritual/Biblical tools & scripture for peace, love and healing family trauma.Epigenetic tools.Scientific tools to calm down your child and your nervous system.Food tips to avoid autism symtoms, meltdowns and triggers. Get her free Christmas food guide and neuro-provoking foodlist HERE.Here are 3 ways we can start turning autism symptoms around together, whenever you're ready... 1. Send me a voice message and get my feedback on your most pressing struggles. 2. Check out the free video series "The 5 hidden messages behind autism symptoms" and find your child's unique triggers. 3. Work with me privatelyIf you'd like to work with me directly to turn as many symptoms around as possible in my Autism Turnaround Coaching and implementation group..send me an email with "coaching" in the subject line and tell me how old your child is. I'll get you all the details.

Are you looking for ways to turn back the clock? As a specialist in anti-aging, regenerative, and functional medicine, Dr. Paziotopoulos incorporates a variety of disciplines into his practice to ensure individuals enjoy a long and happy life. He values building the long-term relationships that are necessary to co-create a roadmap for longevity and good health. I learned a lot from this conversation and I hope you will as well.    What we discussed:    Dr. Paziotopoulos's journey into anti-aging (1:18) Medical maintenance engineering and points of failure (3:43) The future of anti-aging and longevity (7:46) Challenges in the current healthcare system (9:50) Sustainability and population growth (13:33) The future role of AI and genetic engineering (18:29) His personal motivation and approach to health (20:46) Patients' struggle with certain behavioral traits and anxiety (24:52) Epigenetic traits passed down through generations (25:54) Science and living "forever" (30:21) Regenerative medicine, aging, and facing death (39:34) Personal nutrition choices (43:44) The impact of diet on the microbiome and the importance of regular testing (1:03:24)   Where to learn more:    The Pazio Institute   If you loved this episode and our podcast, please take some time to rate and review us on Apple Podcasts, or drop us a comment below!

Empaths & Starseeds: Healing Ancestral Memories of the Orion Wars

Ep. 157 On today's episode of Pursuit of Wellness, Dr. Tyna Moore, a naturopathic and chiropractic physician with expertise in regenerative medicine, joins us to provide clarity on GLP-1 medications. With a background in metabolic health and chronic pain management, Dr. Tyna explains how GLP-1s can benefit individuals with weight loss goals, PCOS, and insulin resistance. She shares valuable advice on individualizing doses, understanding how these medications interact with insulin and muscle mass, and how to approach conversations with doctors about your dosage. We also cover the risks associated with Ozempic, especially in those dealing with metabolic dysfunction, and discuss how these drugs impact areas like fertility and chronic pain. Leave Me a Message - click here! For Mari's Instagram click here! For Pursuit of Wellness Podcast's Instagram click here! For Mari's Newsletter click here! For Dr. Tyna's Instagram click here! For Dr. Tyna's Website click here! Sponsored By:  The holidays are closer than ever, so make sure you order by December 16th to get their gift (or yours) underneath the tree in time! Visit Carawayhome.com/POW to take advantage of this limited-time offer for up to 20% off your next purchase. Again that's Carawayhome.com/POW to get new kitchenware before the holidays. Caraway. Non-Toxic cookware made modern. Visit BetterHelp.com/POW today to get 10% off your first month. That's betterhelp.com/POW. Head to Manukora.com/POW to get $25 off the Starter Kit, which comes with an MGO 850+ Manuka Honey jar, 5 honey travel sticks, a wooden spoon, and a guidebook! Visit clearstemskincare.com and use code POW at checkout for 20% off your first purchase. Again, that's code POW for 20% off your first purchase on clearstemskincare.com. The Fits Everybody collection is available in sizes XXS to 4X. You can shop now at SKIMS.com. After you place your order, be sure to let them know I sent you! Select "podcast" in the survey and be sure to select my show in the dropdown menu that follows. And if you're looking for the perfect gifts for the whole family - SKIMS just launched their biggest Holiday Shop ever - also available at SKIMS.com.  Show Links: Ozempic Uncovered University   Dr. Tyna's GLP1s Done Right Dr Tyna GLP1 Episodes  Finding A Doctor  Episode Keywords + Tags (YouTube) Health, Wellness, Fitness, Nutrition, Pursuit of Wellness, Dr. Tyna, Semaglutide, Microdosing, Weight Loss, GLP-1, Regenerative Medicine, Metabolic Health, Podcast Host, Peptide, PCOS, Obesity, Fertility, Social Media Influencers, Mucus, Mucinex, TikTok, Cystic Acne, Epigenetic, Infertility, Spironolactone, Androgen, Orthorexia, Peptide, Menstrual Cycle, Anti Inflammatory, Pharmaceuticals, Hormones, Insulin Signaling, Insulin Reception, Insulin Resistant, Metabolic Pathways, Waist Circumference, Skinny Fat, Muscle Mass, Toned, Lean, Arm Sculpting, Crohn's, Microbiome, Ozempic, Muscle Loss, Heroin Chic, Chain Smoking, Metabolic Dysfunction, Dosage, Individualized Dosing, Freedom, Chronic Pain Topics Discussed 00:00:00 - Introduction  00:03:54 - Dr. Tyna's journey 00:06:44 - Initial success stories 00:07:54 - Fertility  00:09:20 - GLP-1's and cystic acne 00:16:22 - PCOS diagnosis 00:21:09 - Low dose GLP-1 benefits 00:29:18 - Who metabolic health applies to 00:31:53 - Pick up the weights! 00:34:41 - GLP-1's and the microbiome 00:37:20 - Ozempic mistakes 00:41:49 - How Ozempic affects the body 00:45:24 - Individualized dosing 00:48:01 - How to talk to your doctor about low dosing 00:52:56 - Cycling do's and don'ts 00:54:05 - Clarity around the different drugs 01:00:01 - GLP-1's and addiction 01:02:46 - Dr. Tyna's Ozempic Done Right University 01:05:45 - Wellness to Dr. Tyna

Subscribe to our channel: https://www.youtube.com/@optispan In this episode of the Optisan Podcast, Dr. George Sutphin discusses biological age tests, focusing on epigenetic and glycan age assessments. The conversation explores the accuracy, relevance, and implications of these tests for understanding biological versus chronological age. Key topics include the limitations of current biomarkers, the impact of lifestyle on aging metrics, and the challenges of interpreting results. The discussion emphasizes the need for caution in marketing claims and the importance of scientific validation in biological age testing. 00:00 - Intro 00:36 - Discussion on biological age tests 04:10 - Defining biomarkers of aging 07:21 - The role of epigenetics in biological aging 10:25 - Skepticism about consumer marketed tests 15:07 - Results from Dr. Sutphin's epigenetic age test 18:51 - Discussion on diet, exercise, and stress 22:30 - Emotional impact of biological age results 26:03 - Summary of organ age results from glycan age test 30:17 - Variability in test results and implications 33:08 - Exploring additional biomarkers for biological age 40:11 - Final thoughts on glycan age and epigenetic clocks 45:21 - Conclusion and takeaways from the discussion Producers: Tara Mei, Nicholas Arapis Video Editor: Jacob Keliikoa DISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices. More places to find us: Twitter: https://twitter.com/optispanpodcast Twitter: https://twitter.com/optispan Twitter: https://twitter.com/mkaeberlein Linkedin: https://www.linkedin.com/company/optispan Instagram: https://www.instagram.com/optispanpodcast/ TikTok: https://www.tiktok.com/@optispan https://www.optispan.life/ Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it. On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!

Now here's a fascinating discussion on how we can test our dogs' DNA to determine things like age, breed, predisposition of different diseases and even certain behavioral traits. And these simple tests can be done from the comfort of your own home. Dr. Judy welcomes Dr. Matteo Pellegrini, a biophysicist and Founder of ProsperK9 and shares more about the difference between epigenetics and genetics, DNA methylation and what it can tell us about a dog, how that is measured and the future of genetic and epigenetic testing. There are so many wonderful applications to this testing. Learn more by listening in! URL http://pellegrini.mcdb.ucla.edu https://prosperk9.com/ PRODUCT SPOTLIGHT #1: An Integrative Approach to Hospice and Palliative Care for Dogs Are you looking for the ultimate one stop resource for canine hospice and palliative care? Then you need to check out our recent course, An Integrative Approach to Hospice and Palliative Care for Dogs. There are three versions to this course that also include live meetings and a certification option. These informative courses are led by Dr Judy Morgan and Michele Allen, two experts in dog hospice. Dr Judy covers the integrative veterinary medicine aspect of hospice and tackles the real life experiences and care expertise. The combination of these two skill sets has created the best online course for knowledge on dog hospice. As a thank you to our podcast listeners use code PODCAST45 for 20% off any of these hospice related courses found only on DrJudyU.com PRODUCT SPOTLIGHT #2: Do you have a senior dog in your family? Why not help to support their physical and mental well being by giving them 100% natural Dr Judy's Senior Formula? Recommended for all breeds to support healthy joints, cognitive function, cardiovascular health, and it helps to reduce the negative effects of stress. For optimum health, order yours today on DrJudyMorgan.com and save 10% off with code PODCAST45

Do you know your biological age? How does one learn their biological age and how is it different from your chronological age? The answer lies in our epigenetics, which is how you live your life! In this fascinating episode of Salad with a Side of Fries, Jenn welcomes Hannah Went, co-founder of TruDiagnostic, to explore the science behind biological age testing. Together, they dive into the cutting-edge world of epigenetics, methylation, and the role of lifestyle in optimizing health. From understanding how epigenetic markers can predict disease risks to uncovering how simple changes can slow aging, this episode is packed with insights that could transform how you think about your health and longevity. The Salad With a Side of Fries podcast is hosted by Jenn Trepeck, discussing wellness and weight loss for real life, clearing up the myths, misinformation, bad science & marketing surrounding our nutrition knowledge and the food industry. Let's dive into wellness and weight loss for real life, including drinking, eating out, and skipping the grocery store. IN THIS EPISODE: [1:57] What is your biological age?[6:04]  Hannah describes epigenetics and what they target in the blood through various tests.[9:54] What is methylation?[12:53] How is epigenetic testing different from Elizabeth Holmes and Theranos?[15:38] What are the privacy implications of taking these tests, and what can the tests reveal?[22:49] Studies around epigenetic information.[25:42] Slowing the progression of biomarkers that create disease.[29:05] Lifestyle changes can positively impact stress and overall health[32:19] There is power in testing.[33:39] Choosing the most compatible testing company.KEY TAKEAWAYS: Genetics and epigenetics offer complementary insights into human biology. Genetics represents the fixed "hardware" inherited equally from each parent, while epigenetics is the dynamic "software" influenced by interactions with the environment and personal behaviors. Unlike static genetic markers, epigenetic markers are often changeable, though some—like imprint markers—may be inherited, presenting exciting opportunities for biomarker discovery.While the classification of aging as a disease may be debated, it's clear that biological age clocks are becoming powerful tools for detecting disease signals. For example, one clock has shown 92% accuracy in predicting mortality, compared to 72% for chronological age. These biomarkers are improving and will soon include methylation risk scores for specific diseases, helping to assess individual disease risks more precisely. Aging may serve as a general indicator, providing valuable insights into disease likelihood and guiding interventions for better health outcomes.Aging and health assessments, like biological age testing, can serve as a valuable wake-up call, especially for those with room for improvement in their health and lifestyle. While biohacking and excessive supplementation are popular, they often lack clarity and balance, making it difficult to pinpoint what's truly effective. Simplicity is vital—maintaining a balanced approach is more beneficial than overloading the body with too many interventions, which can disrupt homeostasis and lead to less favorable results.QUOTES: [6:19] “I like to break down the word. So epi is a Greek prefix that actually just means above or on top of. So we're quite literally just looking on top of your genetics.” Hannah Went[7:25] “You can change your epigenetics and control your health. You can no longer blame, you know, your predisposition for disease based on your second cousins.” Hannah Went [7:40] “We are in control of our health. Genetics are this predisposition, but not a determining, inherent absolute.” Jenn Trepeck[12:14] “Epigenetics is actually a better marker in some cases in terms of disease predictability, odds ratios, hazard ratio and that's the point of the biomarker. How close can we get to that disease prediction?” Hannah Went[14:03] “Epigenetic tests are not a replacement for traditional lab tests. Instead, they're just providing a unique layer of insight into how your environment and lifestyle may be affecting your particular genes.” Hannah Went[27:18] “We can look at these results and let it be a wake up call to say,  I may have different data so, I might want to make some lifestyle changes.” Jenn Trepeck[33:09] “You see things on social media nowadays, like ‘food is medicine'. ‘You are what you eat'. ‘Your DNA is not your destiny'.  That's epigenetics. They're quite literally describing epigenetics without saying the word.” Hannah Went[35:06] “People get confused between what's truly genetic and what is inherited lifestyle. Something might run in your family, that doesn't necessarily mean it's genetic because the other thing that runs in families is lifestyle choices and habits.” Jenn TrepeckRESOURCES:Become A Member of Salad with a Side of FriesJenn's Free Menu PlanA Salad With a Side of FriesA Salad With A Side Of Fries MerchA Salad With a Side of Fries InstagramNutrition Nuggets for Epigenetics EpisodeGUEST RESOURCES: Everything Epigenetics - PodcastTrudiagnostic - WebsiteEverything Epigenetics - InstagramEverything Epi - TwitterGUEST BIOGRAPHY: Hannah Went has a lifelong passion for longevity and breakthrough, disruptive technologies that drive radical improvement to the human condition. She attended the University of Kentucky and graduated with a degree in Biology. She had multiple research internships studying cell signaling and cell biology then. After graduation, she worked for the International Peptide Society as their Director of Research and Content. Through work in the integrative medicine industry, Hannah saw an opportunity for methylation-based age diagnostics and started TruDiagnostic in 2020. TruDiagnostic focuses on methylation array-based diagnostics for life extension and preventive healthcare, serving functional medicine providers. TruDiagnostic is committed to research, with over 30 approved clinical trials investigating epigenetic methylation changes in longevity and health interventions. Since TruDiagnostic's inception, they have created one of the world's largest private epigenetic health databases, with over 75,000 patients tested. Hannah has since created Everything Epigenetics, sharing insights on how DNA regulation impacts health. 

What if aging was optional? Or what if you actually have control over your genetics or genetic dispositions to diseases and the like? In today's episode, Hannah Went, TruDiagnostic, explore the powers of epigenetics in optimizing health & longevity. “Find out about biological age clocks, the role of fat-soluble vitamins, & how lifestyle changes outperform pharmaceuticals in slowing aging. Hannah discusses tools like the True Health Report, methylation risk scores, and advanced tracking technologies to help you take control of your health journey. Learn about all this and more in today's episode on Everything Epigenetics Meet our guest Hannah Went is a biology graduate from the University of Kentucky with a passion for longevity & disruptive technologies. She has a background in cell signaling research & served as Director of Research & Content for the International Peptide Society. In 2020, she founded TruDiagnostic, a company specializing in methylation-based diagnostics for life extension & preventive healthcare. TruDiagnostic conducts extensive research, with over 30 clinical trials & one of the world's largest private epigenetic health databases, testing over 35,000 patients. Hannah also created Everything Epigenetics to share insights on how DNA regulation impacts health. Thank you to our partners Outliyr Biohacker's Peak Performance Shop: get exclusive discounts on cutting-edge health, wellness, & performance gear Ultimate Health Optimization Deals: a roundup article of all the best current deals on technology, supplements, systems and more Gain mental clarity, energy, motivation, and focus with the FREE Outliyr Nootropics Mini-Course The simple, guided, and actionable Outliyr Longevity Challenge helps you unlock your longevity potential, slow biological aging, and maximize your healthspan Key takeaways Your genetics, or DNA code, act as your hardware—unchanging & responsible for about 20% of your phenotypic outcomes Epigenetics, the software of your genetics, control how genes are expressed. They are modifiable & account for 80% of health outcomes Most genomic testing companies analyze the same genetic positions, but the key difference lies in interpretation Epigenetics serve as a reliable biomarker, providing a running average of the past 3–6 months. They are stable yet adaptable Blood labs can mislead if not done thoroughly, regularly, or analyzed for long-term trends. Variability in lab results can create the illusion of issues where none exist Biological age clocks predict future health outcomes using biomarkers, but their value depends on how well they forecast specific diseases Epigenetics integrate other aging factors, refined by how the algorithms are trained Episode Highlights 7:39 Understanding The Difference Between Genetics & Epigenetics  15:03 Hierarchy of Diagnostics & Testing 26:58 Advantages & Disadvantages of Data Tracking & Wearable Technology 39:00 How to Personalize Your Health Using Data & Test Results 48:00 The Best Longevity Protocols & Supplementation Links Watch it on YouTube: https://youtu.be/bWEJ3DTYGHU  Full episode show notes: mindbodypeak.com/184 Connect with Nick on social media Instagram Twitter YouTube LinkedIn Easy ways to support Subscribe Leave an Apple Podcast review Suggest a guest Do you have questions, thoughts, or feedback for us? Let me know in the show notes above and one of us will get back to you! Be an Outliyr, Nick

We all want to grow old and be WELL! Growing old and becoming ill or infirmed is something people don't believe will ever happen to them. Nursing homes and assisted living facilities are proliferating because of this mistaken belief. The third part of this series on anti-aging will discuss the importance of STRESS in Anti-aging. Data is still lacking to establish a clear relationship between stress resistance and slowing the aging process. Epigenetic age and chronologic age can be completely different. What is this and what does it mean to reversing the aging process?. This show will discuss the benefits and the methods that can be used to retard aging.

Featuring an interview with Dr Gilles Salles, including the following topics: Epigenetic modifications and the role of EZH2 in the pathobiology of follicular lymphoma (FL) (0:00) Natural history of FL and current treatment landscape in the first-line setting (5:20) Testing approaches for the detection of EZH2 mutations (14:37) Mechanism of action of the EZH inhibitors tazemetostat and valemetostat (18:31) Tazemetostat monotherapy as treatment for relapsed/refractory FL (20:58) Ongoing evaluation of novel treatment approaches with tazemetostat for FL and other lymphomas (25:31) Approved indications for tazemetostat for wild-type FL and FL with EZH2 mutations; sequencing of tazemetostat with bispecific antibodies and CAR T-cell therapy (34:07) Available clinical data with the novel dual EZH1/EZH2 inhibitor valemetostat (42:37) Personal experience with CAR T-cell therapy and perspectives on possible underlying reasons for the development of T-cell lymphoma in patients receiving this treatment (44:35) Management of FL in patients who experience relapse within 24 months of receiving treatment (POD24) (48:25) Myths or misperceptions associated with tazemetostat and other therapies approved in the relapsed FL setting (52:15) Perspectives on the future treatment landscape of FL (54:29) CME information and select publications

This episode is packed with practical insights and inspiring moments, as Judy and Dr. Alisa discuss strategies for confronting fear, reshaping self-talk, and overcoming limiting beliefs. Judy explains how recognizing generational patterns can empower individuals to shift perspectives and create new paths to success. They also touch on Judy's “3.0 version” approach, strategies for visionary leadership, and coaching techniques to build resilience and foster transformation within organizations. Whether you're seeking personal growth, leadership skills, or a deeper understanding of how ancestral patterns influence your journey, this episode offers a profound guide to unlocking potential.Connect and Contact Judy Wilkins-Smith:Website: https://judywilkins-smith.com/Instagram: @judywilkinssmithFacebook: Judy Wilkins-SmithLinkedIn: Judy Wilkins-SmithYouTube: Judy Wilkins-Smith ChannelJudy's Books:The Hidden Power in Your DNA: How to Use Genealogy to Explore Ancestral Patterns & Transform Your LifeDecoding Your Emotional Blueprint: A Powerful Guide to Transformation Through Disentangling Multigenerational Patterns (Sounds True)Connect and Contact Dr. Alisa Whyte on Mindset Mastery Moments and Mindset Mastery 360:Mindset Mastery Moments: WebsiteMindset Mastery 360: WebsiteBecome a supporter of this podcast: https://www.spreaker.com/podcast/mindset-mastery-moments--4488172/support.

In this enlightening episode of Mindset Mastery Moments, Dr. Alisa Whyte welcomes world-renowned systemic coach and trainer Judy Wilkins-Smith. Together, they dive into the transformative concepts of "Success DNA" and "Relationship DNA," focusing on how epigenetic and ancestral patterns impact both our personal and professional lives. Judy, founder of System Dynamics for Individuals & Organizations, shares insights from her extensive experience with Fortune 500 clients, including NASA, Microsoft, JP Morgan, and others. Their discussion delves into Judy's groundbreaking approach to systemic work, using constellations to uncover and transcend inherited blocks that can hinder success.As they explore emotional DNA, Dr. Alisa and Judy discuss how our thoughts, feelings, and actions are shaped by ancestral patterns and often limit our potential. Judy explains the practice of constellation therapy as a way to make hidden beliefs visible and actionable, allowing individuals to rewire their "Success DNA" for meaningful growth. Dr. Alisa and Judy's conversation also covers the idea of embracing cultural heritage with confidence, breaking free from societal limitations, and the power of understanding one's own unique success blueprint.Connect and Contact Judy Wilkins-Smith:Website: https://judywilkins-smith.com/Instagram: @judywilkinssmithFacebook: Judy Wilkins-SmithLinkedIn: Judy Wilkins-SmithYouTube: Judy Wilkins-Smith ChannelJudy's Books:The Hidden Power in Your DNA: How to Use Genealogy to Explore Ancestral Patterns & Transform Your LifeDecoding Your Emotional Blueprint: A Powerful Guide to Transformation Through Disentangling Multigenerational Patterns (Sounds True)Connect and Contact Dr. Alisa Whyte on Mindset Mastery Moments and Mindset Mastery 360:Mindset Mastery Moments: WebsiteMindset Mastery 360: WebsiteBecome a supporter of this podcast: https://www.spreaker.com/podcast/mindset-mastery-moments--4488172/support.

In this episode of the Epigenetics Podcast, we talked with Mitinori Saitou from Kyoto University about his work on germ cell development, focusing on proteins like BLIMP1 and PRDM14, reprogramming iPSCs, and his vision to address infertility and genetic disorders through epigenetic insights. To start our discussion, Dr. Saitou shares the foundation of his research, which centers on the mechanisms of germ cell development across various species, including mice, non-human primates, and humans. He provides insight into his early work examining the roles of two key proteins: BLIMP1 and PRDM14. These proteins are essential for germline specification in mammals, and their functions are unveiled through detailed exploration of knockout models. In particular, Dr. Saitou elucidates the critical events in germ cell specification, highlighting how disruptions to the functions of these proteins lead to significant impairments in development. As the conversation deepens, we discuss Dr. Saitou's groundbreaking advances in human-induced pluripotent stem cells (iPSCs). He elaborates on the processes involved in reprogramming these cells to form primordial germ cell-like cells, emphasizing the significance of understanding various cellular contexts and transcriptional regulation. Dr. Saitou then details how overexpression of certain factors in embryonic stem cells can induce these germline characteristics, presenting the promise of innovation in regenerative medicine and reproductive biology. We end our talk with the exploration of chromatin remodeling that occurs during germ cell development, including fascinating details about DNA and histone modification dynamics. Dr. Saitou articulates how the epigenetic landscape shifts during the transition from pluripotent states to germ cell specification, providing a detailed comparison between mouse and human systems. This highlights the complexity of gene regulation and the importance of specific epigenetic markers in establishing and maintaining cellular identity.   References Yamaji, M., Seki, Y., Kurimoto, K. et al. Critical function of Prdm14 for the establishment of the germ cell lineage in mice. Nat Genet 40, 1016–1022 (2008). https://doi.org/10.1038/ng.186 Katsuhiko Hayashi et al., Offspring from Oocytes Derived from in Vitro Primordial Germ Cell–like Cells in Mice. Science 338, 971-975 (2012). DOI: 10.1126/science.1226889 Nakaki, F., Hayashi, K., Ohta, H. et al. Induction of mouse germ-cell fate by transcription factors in vitro. Nature 501, 222–226 (2013). https://doi.org/10.1038/nature12417 Nakamura, T., Okamoto, I., Sasaki, K. et al. A developmental coordinate of pluripotency among mice, monkeys and humans. Nature 537, 57–62 (2016). https://doi.org/10.1038/nature19096 Murase, Y., Yokogawa, R., Yabuta, Y. et al. In vitro reconstitution of epigenetic reprogramming in the human germ line. Nature 631, 170–178 (2024). https://doi.org/10.1038/s41586-024-07526-6   Contact Epigenetics Podcast on X Epigenetics Podcast on Instagram Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Epigenetics Podcast on Threads Active Motif on X Active Motif on LinkedIn Email: podcast@activemotif.com

Ready to take control of your health and well-being? In this episode of the Visibly Fit Podcast, I dive into the transformative power of journaling and discovering your “why.” Learn how your thoughts, choices, and environment can impact your genetic makeup through the concept of epigenetics.Feeling stuck in unhealthy habits or negative thinking? You're not alone. I'll share practical tips to help you break free and live a more vibrant, fulfilling life. Discover how to harness the power of your mind to change your genetic expression, boost your physical and mental health, and find more joy in everyday living.Grab your journal and let's start this journey together. You have the power to change your health story!Chapters:[00:00] Podcast Preview[01:03] Welcome to Visibly Fit Podcast[01:35] Importance of Journaling for Health[02:27] Keeping Your Why in Front[03:53] Questions to Ask While Journaling[05:38] Impact of Brain on Cells[07:05] Understanding Epigenetics[08:18] Biblical Perspective on Mind and Heart[10:06] Power of Positive Thinking[12:03] Subconscious Beliefs and Health[13:46] Placebo Effect in Healing[14:49] Breaking Cycles of Disease[16:08] Importance of Healthy Choices for Future Generations[18:09] Changing Genetic Expression[20:09] Epigenetics Beyond Childbearing Age[21:04] Power of Positive Actions[22:08] Daily Choices and Genetic Coding[23:25] Clean Environment and Mental Clarity[25:27] Seasonal Changes and Stress Management[26:44] Holistic Health and Epigenetics[28:09] Invitation to Work Together[29:44] Conclusion and Contact InformationResources mentioned:Visibly Fit 7-Week Accelerator ProgramP.S. If you're just checking out the show to see if it's a good fit for you, welcome!If you're really serious about becoming Visibly Fit, you'll get the best experience if you download the worksheets available at https://wendiepett.com/visiblyfitpodcast.

Michael Miller is co-founder of London and New York Meditation Centers, a full-time Vedic Meditation teacher, wellness expert and podcast host. Michael discovered Vedic Meditation working as an executive in the entertainment industry in LA and noticed the benefits right away: more energy, better sleep and greater clarity. Michael brings this experience to his teaching in a down-to-earth way — understanding the challenges people face in their busy lives, and how to balance this with staying well, creative and happier. He's recognised as a leading expert in his field, teaching thousands across the globe, hosting a popular podcast, Speaking of Meditation, and leading meditation retreats in India, Europe and the States. In this episode, Michael Miller talks about how meditation works, his personal journey to building the habit of meditation, tips on what to do if you're struggling with it and the power of having awareness in our life. Learn more about Michael Miller: https://newyorkmeditationcenter.com, https://www.londonmeditationcentre.com Instragram: @newyorkmeditation, @londonmeditationcentre Get Why Meditate book by Jillian Lavender here: https://amzn.to/47JiRH6 CHAPTERS: 0:00 Intro 3:30 Mantra 9:38 Struggling with meditation 25:00 Consciousness & awareness 36:15 Epigenetic reset 46:00 'Why meditate' Book

It's important to me to include a variety of voices in the sphere of aging and longevity, and Matt Kaeberlein PhD is certainly one that I appreciate for his tempered and rational arguments. I value his insights and his work with other scientists who are tussling with the challenging questions and research interpretations in this field. We are at this extraordinary inflexion point where scientists are debating the very definition of aging itself, which has important implications for how we then measure and study it. Dr. Kaeberlein shares his thoughts on this as well as the latest on longevity interventions such as rapamycin, metformin, intermittent fasting, and caloric restriction. Find out why he thinks we'll always hit a wall with moving the needle on lifespan, and why healthspan is such an important target. I think you will find this conversation illuminating and useful. An additional note for any of my listeners/readers who have been tracking the various discussions around the utility of epigenetic clocks and other measures of aging: I personally very much believe in epigenetics, even as the field continues to evolve. The foundation of this traces back to my beginnings in this field, working under my mentor Richard Lord PhD, who taught me that as scientists and clinicians we have no choice but to embrace uncertainty. No laboratory tests are as precise as many of us would like to think they are - microbiome, organic acid, nutrient testing, those foundational tools of functional medicine that we are very comfortable using, included. This applies to standard labs too - I recently received a notification from one of the two biggest labs in the US stating that, due to a change in the testing instrument used, values for red cell indices (the oldest tests on the planet!) would be altered compared to prior results. As clinicians we have to grapple with uncomfortable uncertainty in medicine every single day - from that reality we still have to move forward and make the best clinical decisions we can. Epigenetic age testing is simply another tool in the mix that can add value to understanding a patient's picture, and we can use it even as we interpret it with a similar acknowledgement of uncertainty. If you would like to add your thoughts to this discussion, please share below. - DrKF Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources. GUEST DETAILS Matt Kaeberlein, PhD, CEO, Optispan https://tinyurl.com/2r89rvdd Email Matt@optispan.life THANKS TO OUR SPONSORS DIAMOND Rupa Health: https://tinyurl.com/4anbz7b3 Biotics Research: https://www.bioticsresearch.com/ Integrative Therapeutics: https://tinyurl.com/4emwj48z GOLD TimeLine Nutrition: https://tinyurl.com/bdzx2xms OneSkin: https://tinyurl.com/ycxtw4zt MIDROLL DUTCH: Learn more about DUTCH testing https://tinyurl.com/2y24st67 QUALIA: Try Qualia Senolytic with code KARA15 for 15% off at http://qualialife.com/Kara15 CONNECT WITH Dr. Fitzgerald on YouTube: https://tinyurl.com/hjpc8daz

Welcome back to another episode of The Realfoodology Podcast! Today we're exploring the world of epigenetic coaching, genetic testing, and the exciting realm of peptides. I had the pleasure of sitting down with Lindsay from Designer Genes Co., where we discuss what it means to be an epigenetic coach and the transformative insights that genetic testing can offer. We also cover peptides in detail, including GLP-1 and their potential benefits for various health issues. If you're curious about how peptides could impact your health journey, this episode is packed with valuable information you won't want to miss! Timestamps:  06:36 - Epigenetic coaching  11:10 - COMT & your body's stress chemistry  15:54 - Body By Design DNA Testing  18:40 - BDNF  23:26 - Peptides overview  32:37 - Understanding the rise in peptide use  35:13 - Impacts of peptides  41:58 - Unpacking side effects and risks of GLP1s  48:58 - GLP1 dosing  51:58 - Triceptides  55:01 - Peptide shortages & regulation  57:03 - Peptides impact on Big Food 01:00:24 - KPB & BPC157  01:04:00 - Lindsey's favorite peptides  01:07:05 - Personal fitness journeys  01:09:36 - Cognitive function peptides  01:11:39 - Getting peptides  01:14:58 - Lindsey's health nonnegotiables  Use Code REALFOODOLOGY for 10% off any of the following: Body By Design® DNA testing  PepSquad Peptide Therapy Course KNOCKOUT Bundle (includes testing and peptides course)   Sponsored By: Organifi Go to www.organifi.com/realfoodology and use code REALFOODOLOGY for 20% Off Cured Nutrition Go to www.curednutrition.com/realfoodology and use code REALFOODOLOGY for 20% off Paleovalley Save at 15% at paleovalley.com/realfoodology and use code REALFOODOLOGY Needed Use code REALFOODOLOGY at thisisneeded.com for 20% off Timeline Go to timelinenutrition.com/REALFOODOLOGY and use code REALFOODOLOGY for 10% off LMNT Get your free Sample Pack with any LMNT drink mix purchase at drinklmnt.com/realfoodology Check Out Lindsey: Instagram Website Check Out Courtney:  LEAVE US A VOICE MESSAGE Check Out My new FREE Grocery Guide! @realfoodology @realfoodologypodcast www.realfoodology.com My Immune Supplement by 2x4 Air Dr Air Purifier AquaTru Water Filter EWG Tap Water Database Produced By: Drake Peterson

Epigenetic clocks have become established as robust measures of chronological age, surpassing telomere length as the best age predictor.

Episode Highlights With Hannah WentWhat biological age is and how we measure itUnderstanding cellular-based aging How we measure biological ageSprint speed and grip strength can be really loose indicators of biological ageUnderstanding epigenetic biomarker proxies and how to pull levers to improve your biological ageHow biological age is closely tied to all-cause mortality The biggest factors that affect biological age negatively or positively Not surprisingly, smoking and alcohol consumption are negative factors for biological ageDiet, physical activity, sleep, and stress make a big impact on biological ageHow caloric restriction comes into play for aging Pregnancy and menopause effects on aging Epigenetic transgenerational inheritance and how this affects our kidsHow sunlight affects biological age (and it might not be what you think)Spending time in green space and in nature has a positive effect on biological age and even IQBeing lonely is worse than smoking according to research from HarvardHow relationships and community improve biological ageResources We MentionTruDiagnostic (this link and code wellnessmama gives a discount)Hand Grip Strength Tester