study of heritable DNA and histone modifications that affect the expression of a gene without a change in its nucleotide sequence.
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Episode 202: BPA OverviewWritten by Cameron Carlisle, MSIV, Ross University School of Medicine. Comments by Hector Arreaza, MD.You are listening to Rio Bravo qWeek Podcast, your weekly dose of knowledge brought to you by the Rio Bravo Family Medicine Residency Program from Bakersfield, California, a UCLA-affiliated program sponsored by Clinica Sierra Vista, Let Us Be Your Healthcare Home. This podcast was created for educational purposes only. Visit your primary care provider for additional medical advice._____________________Arr: Welcome to another episode of Rio Bravo qWeek. My name is Hector Arreaza, I'm an associate program director and faculty in the Rio Bravo Family Medicine Residency Program. Today my co-host is Cameron Carlisle, who is a 4th-year medical student finishing his last rotation of med school. Welcome, Cameron, please introduce yourself.Arreaza: What are we talking about today, Cameron?Cam: Dr. Arreaza, did you know you're probably carrying around a chemical in your body that mimics estrogen? In fact, a 2004 CDC study found over 92% of Americans had detectable levels of Bisphenol A (BPA) in their urine. Today's topic is BPA.BPA is everywhere: receipts, water bottles, canned foods, baby bottles, and even our dental fillings. It's one of the most ubiquitous endocrine-disrupting chemicals (EDCs), which interferes with the body's hormone systems. That's why today's episode is about making the invisible visible. Our goals for today's podcast:Break down what BPA isShow how it affects the human bodyExplain how you and your patients can limit exposureEmpower both clinicians and the public with real, practical informationArreaza: Thanks for clarifying BPA today. It seems like we always have to learn about a new carcinogen or toxic substance that we are exposed to. I remember when I was a child, Yellow #5 became very concerning for the general public but it is still being used in our foods. So, it's good you are talking about this. What Is BPA?Cam: Bisphenol A (BPA) is an industrial chemical used since the 1950s, primarily in polycarbonate plastics and epoxy resins. It makes plastic clear, and is often found in:Water bottlesCanned food liningsBaby bottles (pre-2012)Takeout containersCash register receiptsDental sealantsArreaza: So, I've seen the “BPA-free” labels many times, and today I'm glad you are going to shed some light about it.Cam: What's alarming is that BPA leaches out of these products, especially when exposed to heat, acidity, or repeated use. A Harvard study found that people who drank from plastic bottles for just one week had a 69% increase in urinary BPA levels (Carwile & Michels, 2009).Arreaza: That's a lot of people 69%. Section 3: What happens when BPA gets into our body? How BPA Works in the BodyCam: BPA is classified as an endocrine disruptor, meaning it can bind to estrogen receptors and mimic or block natural hormone functions.It affects:Reproductive systems (both male and female)NeurodevelopmentThyroid signalingPancreatic β-cell functionMetabolism and fat storageEven low-dose exposure can disrupt cellular function. BPA acts as a xenoestrogen (foreign estrogen) and has been shown to alter DNA methylation, leading to epigenetic changes that persist across generations (Manikkam et al., 2013).Arreaza: So, BPA can cause epigenetic changes that can be inherited. BPA can persist for generations in your offspring.BPA's Health Impacts – What the Research SaysHere's where it gets serious. Let's go system-by-system:1. Reproductive HealthFemales: Linked to PCOS, infertility, and early puberty (Peretz et al., 2014).Males: Reduced sperm count and motility; altered testosterone levels.2. Pregnancy and Birth OutcomesIncreased risk of preterm birth, gestational diabetes, and low birth weight (Snijder et al., 2013).Studies show BPA crosses the placenta, directly affecting the fetus.3. Neurological DevelopmentAssociated with ADHD, anxiety, and impaired executive function in children exposed in utero (Mustieles et al., 2015).4. Metabolism and DiabetesBPA exposure is linked to insulin resistance, obesity, and type 2 diabetes, even at low doses (Lang et al., 2008).5. CancerAnimal and human data link BPA to increased risk of breast and prostate cancer via estrogenic mechanisms.6. MortalityA 2020 JAMA study found individuals with higher BPA levels had a 49% increased risk of all-cause mortality compared to those with lower levels (Gao et al., 2020).Arreaza: You are scaring me. I wonder what my BPA level is in my blood. Actually, BPA can be detected in urine. This is the most common approach for population-level biomonitoring, because BPA and its metabolites are mostly excreted in urine. Studies have found that BPA is present in most people, even up to 85–99% in large cohorts. Cam: That's literally everyone. Sources of BPA ExposureLet's talk about things we use every day:Thermal receipts (like from Target or Starbucks): BPA can transfer onto your skin and be absorbed, especially if your hands are wet or lotioned.Canned soups: One study showed that eating canned soup daily for five days led to a 1000% increased urinary BPA levels (Carwile et al., 2011).Plastic water bottles left in the car on hot days or plastic food trays for microwaving = chemical leaching.Baby bottles and pacifiers (pre-2012): primary concern for newborns.Arreaza: So, Cameron, you were exposed to BPA as a baby.Cam: Here's the jaw-dropper: We ingest up to 5 grams of plastic per week, roughly the weight of a credit card (WWF, 2019; University of Newcastle). This includes microplastics like BPA, which enter through food, water, and air.Arreaza: So, it translates into 40 lbs of plastic in a lifetime, by age 70. What can we do as family physicians?Family Medicine and Preventive CareAs family physicians, we are at the frontlines of prevention. Our role includes:Anticipatory guidance: during prenatal visits, well-child visits, and chronic disease managementScreening opportunities: ask about storage habits, microwave use, and receipt handlingEnvironmental health counseling: AAFP recommends addressing endocrine disrupting chemicals (EDCs) when relevant to a patient's concerns.It's not just about treating diabetes or obesity. It's about recognizing that environmental exposure may be a root cause.Arreaza: Prevention is my favorite topic!Cam: One helpful clinical practice:Arreaza: What else can we do to reduce BPA exposure?Practical Steps to Reduce BPAHere's what patients and doctors alike can do today:Switch to BPA-free products, but be careful, as replacements like BPS or BPF may also be harmful (Rochester & Bolden, 2015).Avoid microwaving or dishwashing plastic containers.Use digital receipts.Filter tap water using carbon filters, which can reduce microparticle ingestion.Choose fresh produce over canned goods when possible.Also, wash your hands after handling receipts, especially before eating or touching your face.Arreaza: What is our government doing to protect us?Public Health and Policy UpdatesRegulations are slowly catching up:The FDA banned BPA in baby bottles and sippy cups in 2012.The European Union has stricter limits, and France banned BPA in all food packaging in 2015.California's Proposition 65 requires BPA warning labels.Arreaza: Proposition 65, passed by direct voter initiative in 1986, “WARNING: This product contains chemicals known to the State of California to cause cancer and birth defects or other reproductive harm.”Arreaza: The FDA is planning to phase out petroleum-based food dyes (certified color additives) from the American food supply – marking a significant milestone in the efforts to protect the public. Cam: Many products still contain BPA analogs (BPS, BPF), which are not yet well-regulated.This is where clinician advocacy matters, where we can guide public opinion and support legislative change.Arreaza: So, millions of pounds of toxic substances are produced by many industries in the US. As physicians, we have to stay informed and update our patients.Cameron: How can we wrap up this episode?Conclusion and TakeawaysBPA is a hormone disruptor hiding in plain sight.People are exposed to BPA every day, but small lifestyle changes can dramatically reduce it.Family medicine has a role in education, prevention, and advocacy.Let's all be part of the solution for our health and future generations. Stanley (tumblers) are not sponsoring this episode, and we did not receive any money from them. Arreaza: That's it for today's episode of Rio Bravo qWeek. If you enjoyed this episode, share it with a colleague or medical student who may need to know about BPA. I'm Dr. Arreaza, signing off.Cameron: Hopefully, in the future I will talk to you about more endocrine disrupting chemicals. Thanks for listening._____________________Even without trying, every night you go to bed a little wiser. Thanks for listening to Rio Bravo qWeek Podcast. We want to hear from you, send us an email at RioBravoqWeek@clinicasierravista.org, or visit our website riobravofmrp.org/qweek. See you next week! _____________________References:Carwile, J. L., & Michels, K. B. (2009). Urinary bisphenol A and obesity: NHANES 2003–2006. Environmental Research, 111(6), 825–830.Carwile, J. L., et al. (2011). Canned soup consumption and urinary bisphenol A: A randomized crossover trial. JAMA, 306(20), 2218–2220.Centers for Disease Control and Prevention (CDC). (2004). Fourth National Report on Human Exposure to Environmental Chemicals.Gao, X., et al. (2020). Urinary bisphenol A and mortality risk. JAMA Network Open, 3(8), e2011620.Lang, I. A., et al. (2008). Association of urinary bisphenol A with medical disorders and laboratory abnormalities in adults. JAMA, 300(11), 1303–1310.Manikkam, M., et al. (2013). Epigenetic transgenerational inheritance of disease. PLOS ONE, 8(1), e55387.Mustieles, V., et al. (2015). Bisphenol A and neurodevelopmental outcomes in children. Environmental Health Perspectives, 123(7), 689–695.Peretz, J., et al. (2014). Bisphenol A and reproductive health. Environmental Health Perspectives, 122(8), 775–786.Rochester, J. R., & Bolden, A. L. (2015). Bisphenol S and F: A systematic review. Environmental Health Perspectives, 123(7), 643–650.Snijder, C. A., et al. (2013). Fetal growth and prenatal exposure to bisphenol A. Environmental Health Perspectives, 121(3), 393–398.World Wildlife Fund (WWF). (2019). No Plastic in Nature: Assessing Plastic Ingestion from Nature to People.University of Newcastle (Australia). (2019). Human Consumption of Microplastics.Theme song, Works All The Time by Dominik Schwarzer, YouTube ID: CUBDNERZU8HXUHBS, purchased from https://www.premiumbeat.com/.
Brad McIntyre, a fourth-generation farmer in Caldwell, Idaho, has transformed his family's operation along the Snake River Basin, scaling back from 3,000 to 1,000 acres due to urbanization and rising costs. Inspired by no-till pioneers, he now manages a diverse farm with seed production, grass-finished beef, pastured pork, poultry, and eggs; all non-GMO. Brad advances regenerative agriculture through no-till farming, diverse rotations, and cover crops, maintaining yields while cutting inputs. He produces locally adapted, high-quality seeds with strong germination for companies like Green Cover Seed. His livestock integration enhances soil health, and direct-to-consumer meat sales promote community health and sustainability. In this episode, John and Brad discuss: Brad's shift from conventional hay work to regenerative farming No-till seed production for brassicas and alfalfa with better germination Epigenetic seed adaptations for local resilience Livestock integration for soil health and direct meat sales Direct-to-consumer marketing with consistent, local products The role of soil health in sustainable farming and stewardship Additional Resources To read Biochemical Individuality by Roger J. Williams, a book exploring how individual biochemical differences influence flavor perception, click here To learn more about Green Cover Seed, visit their website: https://greencover.com/ About John Kempf John Kempf is the founder of Advancing Eco Agriculture (AEA). A top expert in biological and regenerative farming, John founded AEA in 2006 to help fellow farmers by providing the education, tools, and strategies that will have a global effect on the food supply and those who grow it. Through intense study and the knowledge gleaned from many industry leaders, John is building a comprehensive systems-based approach to plant nutrition – a system solidly based on the sciences of plant physiology, mineral nutrition, and soil microbiology. Support For This Show & Helping You Grow Since 2006, AEA has been on a mission to help growers become more resilient, efficient, and profitable with regenerative agriculture. AEA works directly with growers to apply its unique line of liquid mineral crop nutrition products and biological inoculants. Informed by cutting-edge plant and soil data-gathering techniques, AEA's science-based programs empower farm operations to meet the crop quality markers that matter the most. AEA has created real and lasting change on millions of acres with its products and data-driven services by working hand-in-hand with growers to produce healthier soil, stronger crops, and higher profits. Beyond working on the ground with growers, AEA leads in regenerative agriculture media and education, producing and distributing the popular and highly-regarded Regenerative Agriculture Podcast, inspiring webinars, and other educational content that serve as go-to resources for growers worldwide. Learn more about AEA's regenerative programs and products: https://www.advancingecoag.com
What if your cows could tell you exactly what they need to thrive? That's the groundbreaking promise of epigenetics, where the frontier of dairy science meets practical farm management. In this fascinating deep dive, Ian Garner, Head of R&D at Antler Bio, reveals how gene expression technology is revolutionizing dairy farming by unlocking hidden potential beyond traditional genetics. While genetics provides the blueprint, epigenetics determines whether those genetic instructions are actually followed—and this can be influenced by everything from nutrition to environment.Through real-world examples, we discover how farms across Europe are seeing remarkable results by giving their cows a voice through RNA sequencing. One Finnish farm doubled milk production after implementing targeted changes, while most see a 7:1 return on investment within months. The beauty lies in the simplicity: sometimes it's as straightforward as adjusting vitamin supplementation or improving water trough placement based on what the cows' gene expression patterns reveal they truly need.We explore how this technology works practically on farm, from blood sampling to data analysis, and how the recommendations integrate with existing farm management systems. Beyond just boosting production, we discuss the potential for early disease detection, improved fertility, and enhanced animal welfare through preventative intervention based on expression patterns.For forward-thinking farmers looking to maximize performance and profitability, this episode offers a compelling glimpse into dairy farming's future—where understanding the language of gene expression might be the key to unlocking your herd's full potential. Ready to hear what your cows are trying to tell you?Send us a textFor more information about our podcast visit www.chewinthecud.com/podcast or follow us on Instagram @chewinthecudpodcast. ChewintheCud Ltd is also on Facebook & LinkedIn. You can email us directly at podcast@chewinthecud.com
Mainstream medical science tries to convince us that diseases and sickness are passed on genetically, assuring us that there is nothing that can be done. Worse, mainstream medicine then pushes solutions such as genes modification so solve these problems. Epigenetic's is the understanding that most if not all disease and sickness is a result of genetic expression being repressed, while good health is a reflection of genes expressing themselves. The ability for a gene to express itself can be enhanced by ensuring the body is topped off with the 90 essential nutrients it needs. #BardsFM_HealthAndWellness #Epigenetic's #TheBodyTemple Bards Nation Health Store: https://www.bardsnationhealth.com MYPillow promo code: BARDS Go to https://www.mypillow.com/bards and use the promo code BARDS or... Call 1-800-975-2939. Founders Bible 20% discount code: BARDS >>> https://thefoundersbible.com/#ordernow Mission Darkness Faraday Bags and RF Shielding. Promo code BARDS: Click here EMPShield protect your vehicles and home. Promo code BARDS: Click here EMF Solutions to keep your home safe: https://www.emfsol.com/?aff=bards Treadlite Broadforks...best garden tool EVER. Promo code BARDS: Click here Natural Skin Products by No Knot Today: Click here Product Store, Ambitious Faith: Click here Health, Nutrition and Detox Consulting: HealthIsLocal.com Destination Real Food Book on Amazon: click here Images In Bloom Soaps and Things: ImagesInBloom.com Angeline Design: click here DONATE: Click here Mailing Address: Xpedition Cafe, LLC Attn. Scott Kesterson 591 E Central Ave, #740 Sutherlin, OR 97479
Yes, you heard that right. That's not just one or two lucky outliers—that's entire generations of people thriving well into their centenarian years. And here's the kicker: they're not just alive, they are vibrant. They walk, they garden, they socialize, they work and they enjoy life and oh boy, they have a sparkle in their eyes, if you know what I mean. What is their secret? We know it's not just genetics. Their genes are no different than ours. It is epigenetics. How our environment, lifestyle, and daily choices actually switch genes on and off.
In this episode of the Epigenetics Podcast, we talked with Luca Magnani from Institute of Cancer Research and UNIMI in Milan about his work on epigenetic mechanisms of drug resistance and cancer cell dormancy in breast cancer. We start the interview by putting our focus on his significant contributions to the understanding of estrogen receptor-positive breast cancer. In a foundational study from 2013, Professor Magnani and his colleagues illuminated the role of genome-wide reprogramming of the chromatin landscape in conferring resistance to endocrine therapy. This research marked a departure from a purely genetic mutation paradigm, proposing instead that epigenetic modifications play a pivotal role in the development of drug resistance. A fascinating part of our conversation centers on the role of pioneer transcription factors, particularly PBX1, in regulating the estrogen receptor's transcriptional response. Professor Magnani explains how PBX1, typically associated with hematopoietic development, influences estrogen receptor activity, thereby shaping the cancer cell's fate and response to treatment. Continuing our exploration, we discuss the critical distinctions between primary and metastatic breast cancer through the lens of epigenetic reprogramming. By analyzing samples from women with breast cancer, Professor Magnani's work identifies specific enhancer usage that marks the transition to a drug-resistant state which was a breakthrough in linking epigenetic alterations to real-world patient outcomes. He emphasizes that the reliance on genetic mutations alone does not adequately explain the mechanisms of drug resistance, pushing the field to consider the epigenetic landscape more deeply. Our conversation also touches on the evolution of experimental techniques. Professor Magnani shares insights into the transition from traditional ChIP-seq methods to CUT&RUN, demonstrating the need for techniques that cater to the limited material available from clinical samples. This adaptability mirrors the dynamic nature of cancer itself, as cells continuously evolve under therapeutic pressure. As we traverse through the complexities of dormancy and reactivation in cancer cells, Professor Magnani enlightens us on the unpredictable nature of tumor behavior. He describes how cancer cells can enter dormant states and how their awakening is influenced by environmental factors, akin to an evolutionary response to stressors, thus revealing the intricate balance between survival and proliferation. In the latter part of the episode, we explore Professor Magnani's vision for the future of breast cancer research, which includes the need for better animal models that mimic human disease. His pursuit of understanding estrogen receptor behavior both in healthy and cancerous cells reflects a holistic approach to cancer biology, aiming to decipher the transition from normal tissue to malignancy. References Magnani, L., Stoeck, A., Zhang, X., Lánczky, A., Mirabella, A. C., Wang, T. L., Gyorffy, B., & Lupien, M. (2013). Genome-wide reprogramming of the chromatin landscape underlies endocrine therapy resistance in breast cancer. Proceedings of the National Academy of Sciences of the United States of America, 110(16), E1490–E1499. https://doi.org/10.1073/pnas.1219992110 Nguyen, V. T., Barozzi, I., Faronato, M., Lombardo, Y., Steel, J. H., Patel, N., Darbre, P., Castellano, L., Győrffy, B., Woodley, L., Meira, A., Patten, D. K., Vircillo, V., Periyasamy, M., Ali, S., Frige, G., Minucci, S., Coombes, R. C., & Magnani, L. (2015). Differential epigenetic reprogramming in response to specific endocrine therapies promotes cholesterol biosynthesis and cellular invasion. Nature communications, 6, 10044. https://doi.org/10.1038/ncomms10044 Patten, D. K., Corleone, G., & Magnani, L. (2018). Chromatin Immunoprecipitation and High-Throughput Sequencing (ChIP-Seq): Tips and Tricks Regarding the Laboratory Protocol and Initial Downstream Data Analysis. Methods in molecular biology (Clifton, N.J.), 1767, 271–288. https://doi.org/10.1007/978-1-4939-7774-1_15 Related Episodes Enhancers and Chromatin Remodeling in Mammary Gland Development (Camila dos Santos) Contribution of Estrogen Receptor to Breast Cancer Progression (Jason Carroll) Circulating Epigenetic Biomarkers in Cancer (Charlotte Proudhon) Contact Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com
Learn how to slow, and even reverse, your biological age with cutting-edge science on the molecule that controls your longevity. Host Dave Asprey sits down with Dr. Leonard Guarente, an MIT PhD and one of the most respected longevity researchers in the world, to reveal how NAD+, sirtuins, and DNA methylation clocks can help you hack aging, upgrade your mitochondria, and extend your healthspan. This episode gives you the real science, proven by over 250 studies, behind supplements, nutrition, and biohacking tools that actually work for brain optimization, metabolism, and human performance. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR You'll learn why NAD+ is a master regulator of mitochondrial health, how DNA methylation clocks accurately measure biological age, and why boosting sirtuin activity improves resilience, neuroplasticity, and recovery. Dr. Guarente shares insider strategies from decades of functional medicine research, including nootropics, targeted supplements, fasting protocols, and diet adjustments from carnivore to Mediterranean that can shift your metabolism toward longevity. Dave and Dr. Guarente explore advanced biohacks like cold therapy, sleep optimization, and ketosis, plus how to balance these interventions with your genetics, lifestyle, and health goals. You'll also hear about the surprising role of homocysteine in brain aging, how to use lab testing to guide your longevity plan, and why resilience is the ultimate measure of health. You'll learn: • How emotional repression affects brain function, metabolism, and decision-making • Tools for nervous system regulation and emotional healing that drive high performance • Why most people fail without emotional intelligence and internal safety • How somatic awareness can optimize your energy, focus, and relationships • The science of fear, trauma release, and how to turn discomfort into growth • How to coach yourself out of stress, shame, and negative self-talk Whether you want to sharpen your brain, protect your heart, or upgrade your energy systems, this is a masterclass in smarter not harder biohacking for a longer, higher-performing life.Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday, Thursday, and Friday (audio-only) where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. Keywords: NAD+ supplementation, Sirtuin activation, DNA methylation clocks, Biological age testing, Mitochondrial biogenesis, Epigenetic reprogramming, Pterostilbene benefits, Nicotinamide riboside (NR), Nicotinamide mononucleotide (NMN), Homocysteine reduction, Oxidative stress repair, Superoxide dismutase (SOD) activation, Functional medicine longevity, Healthspan optimization, Resveratrol bioavailability, Menopause mitochondrial support, Phenylbutyrate and protein folding, High-fat diet longevity studies, Neurodegenerative disease biohacking, INCHIANTI aging study Thank you to our sponsors! Screenfit | Get your at-home eye training program for 40% off using code DAVE https://www.screenfit.com/dave. Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order. Resources: • Elysium Website. Use code ‘UPGRADE25' for 25% off the first month of a monthly subscription to any Elysium supplement: https://www.elysiumhealth.com/ • Dave Asprey's Website: https://daveasprey.com • Danger Coffee: https://dangercoffee.com/DAVE15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Introduction to NAD & Sirtuins 0:59 — Intro 7:04 — Animal vs Human Aging Studies 10:07 — Discovery of Sirtuins 14:43 — NAD's Role in Aging 15:34 — Resveratrol vs Pterostilbene 23:13 — Timing NAD Supplementation 36:34 — Diet & Lifestyle Factors 50:05 — Elysium's Basis & Signal 1:00:03 — Future Clinical Trials 1:05:14 — Psychology of Aging & Wrap-Up See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
BUFFALO, NY — August 19, 2025 — A new #research paper was #published in Volume 17, Issue 7 of Aging (Aging-US) on July 7, 2025, titled “Epigenetic age and accelerated aging phenotypes: a tumor biomarker for predicting colorectal cancer.” In this study led by Su Yon Jung from the University of California, Los Angeles, researchers found a strong association between accelerated epigenetic aging and an increased risk of colorectal cancer in postmenopausal women. The study also indicated that lifestyle factors influence this risk. Colorectal cancer is one of the leading causes of cancer-related deaths worldwide, particularly in people over the age of 50. However, individuals do not all age at the same biological rate. Two people of the same chronological age can differ in their biological aging, which reflects the condition of their cells and tissues. This study focused on a specific measure of biological aging known as epigenetic aging, which is based on chemical changes to DNA. The researchers used data from the Women's Health Initiative Database for Genotypes and Phenotypes (WHI-dbGaP), which includes genetic and health information from postmenopausal white women aged 50 to 79. They applied three established “epigenetic clocks” to estimate epigenetic age from blood samples collected up to 17 years before a colorectal cancer diagnosis. These clocks measure how quickly a person is aging at the molecular level by tracking DNA methylation. Women with a higher epigenetic age than expected were significantly more likely to develop colorectal cancer “[…]we examined biological aging status in PBLs via three well-established epigenetic clocks—Horvath's, Hannum's and Levine's […].” The study also explored the role of lifestyle in modifying this risk. Women who consumed more fruits and vegetables showed no increased risk, even if they were epigenetically older. In contrast, women with both lower fruit and vegetable intake and signs of accelerated aging were up to 20 times more likely to develop colorectal cancer. This suggests that a healthy diet may help reduce cancer risk associated with biological aging. Another key finding involved women who had both ovaries removed before natural menopause. These women had a higher epigenetic age and, when combined with accelerated aging, a greater likelihood of developing colorectal cancer. This highlights the potential influence of hormonal and reproductive factors on aging and disease risk. The researchers validated their findings across several independent datasets, supporting the potential of blood-based epigenetic aging markers as early indicators of colorectal cancer risk. These markers could help guide early detection and prevention strategies in aging populations. However, the authors emphasize the need for independent large-scale replication studies. Overall, this study contributes to a better understanding of the association between epigenetic aging and cancer. It also supports the idea that modifiable lifestyle factors may reduce disease risk, even among those aging more rapidly at the cellular level. DOI - https://doi.org/10.18632/aging.206276 Corresponding author - Su Yon Jung - sjung@sonnet.ucla.edu Video short - https://www.youtube.com/watch?v=cq1MphQKmSk Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts To learn more about the journal, please visit our website at https://www.Aging-US.com and connect with us on social media at: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM
Guest: David Gate, PhD Patients with Alzheimer's disease—especially APOE4 carriers—show distinct epigenetic immune alterations that may influence disease progression, treatment response, and side effect risk. In this episode, Dr. David Gate, an Assistant Professor of Behavioral Neurology at Northwestern University, dives into his research on this subject and explains how chromatin accessibility in proinflammatory genes and T-cell receptor changes link to neurological pathology.
BUFFALO, NY — August 12, 2025 — A new #research perspective was #published in Aging (Aging-US) on July 8, 2025, titled “Exercise as a geroprotector: focusing on epigenetic aging.” In this perspective, led by Takuji Kawamura from Tohoku University, researchers reviewed existing evidence from scientific studies showing that regular exercise, physical activity, and fitness may influence epigenetic aging and potentially reverse it, offering a promising way to extend healthspan and improve long-term health. Epigenetic aging refers to changes in the body's DNA that reflect how quickly a person is aging at the molecular level. It is measured using epigenetic clocks, which analyze patterns of DNA methylation, a chemical modification that can affect gene activity. Unlike chronological age, which simply counts the number of years lived, epigenetic aging presents a more accurate picture of how well the body's cells and tissues are functioning. This process is influenced by various factors, including lifestyle, and has become a powerful tool for studying aging. This perspective highlights that while general physical activity, such as walking or doing household tasks, offers health benefits, structured exercise routines that are planned, repetitive, and goal-directed appear to have stronger effects on slowing epigenetic aging. Physical fitness, especially high cardiorespiratory capacity, is also closely associated with slower epigenetic aging. The authors also discuss key findings from both human and animal studies. In mice, structured endurance and resistance training reduced age-related molecular changes in muscle tissue. In humans, multi-week exercise interventions demonstrated reductions in biological age markers in blood and skeletal muscle. One study found that sedentary middle-aged women reduced their epigenetic age by two years after just eight weeks of combined aerobic and strength training. Another study showed that older men with higher oxygen uptake levels, a key measure of cardiovascular fitness, had significantly slower epigenetic aging. “These findings suggest that maintaining physical fitness delays epigenetic aging in multiple organs and supports the notion that exercise as a geroprotector confers benefits to various organs.” The research also examines which organs benefit most from exercise. While skeletal muscle has been a central focus, new evidence shows that regular physical training may also slow aging in the heart, liver, fat tissue, and even the gut. In addition, Olympic athletes were found to have slower epigenetic aging than non-athletes, suggesting that long-term, intensive physical activity may have lasting anti-aging effects. The authors call for further research to understand why some individuals respond more strongly to exercise than others and how different types of training influence aging in various organs. They also point out the importance of developing personalized exercise programs to maximize anti-aging benefits. Overall, the findings support the growing recognition that maintaining physical fitness is not only essential for daily health but may also serve as one of the most effective tools for slowing the body's internal aging process. DOI - https://doi.org/10.18632/aging.206278 Corresponding author - Takuji Kawamura - takuji.kawamura.b8@tohoku.ac.jp Video short - https://www.youtube.com/watch?v=Wro3_wBovdE To learn more about the journal, please visit our website at https://www.Aging-US.com and connect with us on social media at: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM
Standard blood tests barely scratch the surface. Ryan Smith shares how TruDiagnostic's TruAge & TruHealth tests use over 1,700 biomarkers from just a drop of blood to measure biological age, hormone health, immunity & more. Go beyond standard labs & start bioharmonizing with cutting-edge precision so you can make decisions that actually impact how you feel & age. Meet our guest Ryan Smith studied Biochemistry at Transylvania University before founding Tailor Made Compounding, which became one of the fastest-growing healthcare companies in the U.S. After exiting in 2020, he launched several ventures, including TruDiagnostic, a CLIA-certified lab specializing in methylation-based diagnostics for longevity & preventive health. TruDiagnostic leads the field with one of the largest private epigenetic databases, over 13,000 patients, & active participation in 30+ clinical research studies. Ryan remains a key figure in advancing functional medicine through innovative health data solutions. Thank you to our partners Outliyr Biohacker's Peak Performance Shop: get exclusive discounts on cutting-edge health, wellness, & performance gear Ultimate Health Optimization Deals: a database of of all the current best biohacking deals on technology, supplements, systems and more Latest Summits, Conferences, Masterclasses, and Health Optimization Events: join me at the top events around the world FREE Outliyr Nootropics Mini-Course: gain mental clarity, energy, motivation, and focus Key takeaways Biological age gives a clearer picture of health risk than birthdate by showing how your body is actually aging Lifestyle basics like exercise, clean eating, stress reduction & social connection remain top tools for aging well Some biological age tests are more reliable thanks to stronger prediction power & actionable results Longevity interventions can now be ranked using technology that tracks measurable improvements over time Leading tests don't just score your age but give clear next steps to improve healthspan & lifespan DNA methylation data offers biomarker proxies that sometimes outperform traditional blood tests Methylation-based tests bring better precision & consistency than standard lab results affected by daily shifts Immune system strength plays a major role in aging by influencing inflammation & clearing damaged cells Supplement & lifestyle tracking tools now show whether specific changes are actually improving key health markers TruAge tests work well for most while biohackers may benefit more from deeper panels like the TruHealth test Episode Highlights 3:29 What Biological Age Really Tells You 10:12 Inside TruDiagnostic's Testing Framework 11:39 Key Lifestyle & Supplement Insights from the Data 15:10 How to Interpret Your Report & Take Action 30:12 Understanding Your Immune & Metabolic Health 45:29 Practical Application & Future of Epigenetic Testing Links Watch it on YouTube: https://youtu.be/MykPl4fZ3Sc Full episode show notes: outliyr.com/221 Connect with Nick on social media Instagram Twitter (X) YouTube LinkedIn Easy ways to support Subscribe Leave an Apple Podcast review Suggest a guest Do you have questions, thoughts, or feedback for us? Let me know in the show notes above and one of us will get back to you! Be an Outliyr, Nick
BUFFALO, NY — July 30, 2025 — A new #research paper was #published in Aging (Aging-US) on July 23, 2025, titled “Second generation DNA methylation age predicts cognitive change in midlife: the moderating role of childhood socioeconomic status.” In this study, led by Sophie A. Bell and Eric Turkheimer from the University of Virginia, researchers investigated how biological aging, measured through DNA methylation, is connected to changes in thinking skills during midlife and whether childhood socioeconomic status influences this relationship. Biological age provides a picture of how the body is aging that goes beyond simply counting years. In this study, researchers used both first- and second-generation DNA methylation clocks—tools that track chemical changes in DNA as markers of aging. GrimAge and PhenoAge, the second-generation clocks designed to reflect broader health and aging processes, were more accurate at predicting long-term changes in Intelligence Quotient (IQ) than the first-generation models that only estimated chronological age. The study analyzed 287 participants from the Louisville Twin Study, which is a long-term project that has followed twins from childhood into midlife. “DNAmAge was estimated with five commonly used algorithms, or epigenetic clocks (Horvath, Horvath Skin and Blood, GrimAge, and PhenoAge).” The results showed that twins with more rapid epigenetic aging had a larger drop in IQ scores. This pattern remained even after considering genetic background and early family environment, made possible by the twin-based design. Importantly, the relationship was strongest in twins who had grown up in families with lower socioeconomic status. This finding suggests that early-life disadvantage may make individuals more vulnerable to the effects of biological aging on brain health. This research adds knowledge to earlier work showing that childhood poverty can influence long-term health. It also highlights the value of second-generation epigenetic clocks as early indicators of brain aging. Unlike the first generation of clocks, these newer tools capture broader biological changes such as inflammation, disease risk, and behaviors like smoking. Although smoking partly explained the results because it strongly influences DNA methylation, it did not fully account for the association between accelerated biological aging and cognitive decline. This suggests that both life experiences and lifestyle factors shape body and brain aging. By combining decades of developmental data with a genetically informed twin design, the study provides new evidence that biological aging, especially when shaped by childhood adversity, is a key factor in midlife cognitive decline. These findings may inform early health strategies that consider both social and biological risks and support the use of second-generation methylation clocks to predict age-related cognitive changes. DOI - https://doi.org/10.18632/aging.206284 Corresponding authors - Sophie A. Bell - bvf7pa@virginia.edu, and Eric Turkheimer - ent3c@virginia.edu Video short - https://www.youtube.com/watch?v=vopDdS1olXw Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206284 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts To learn more about the journal, please visit our website at https://www.Aging-US.com and connect with us on social media at: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM
In this episode of The Light Inside, we explore the intersection of biology and behavior through the lens of epigenetics, genetic predisposition, and trauma-informed mental health care.Our featured guest, Len May, founder of EndoDNA, guides us through groundbreaking research showing how genetic expression can shape everything from stress responses to treatment-resistant depression. We'll learn how behaviors we label as “personal struggles” may, in fact, be inherited—and how understanding our biological code can lead to more ethical, personalized, and integrative models of therapy and healing.Together, we examine how emotional imprinting, unresolved trauma, and somatic incoherence can be passed between generations—and more importantly, how these inherited patterns can be reinterpreted, reintegrated, and transformed.This conversation invites therapists, healers, and practitioners to go beyond surface-level care and into a deeper, evidence-based understanding of how genetics, behavior, and healing intertwine.Key Discussion Themes & Episode Chapters:1. Cold Open – The Inheritance of BehaviorTrauma may not begin with us—but it's often carried by us. We introduce the concept of biological inheritance and explore how behaviors may be encoded into our DNA.2. Meet the Guest: Len MayA pioneer in DNA-guided health and CEO of EndoDNA, Len shares his journey from ADD diagnosis to creating a precision behavioral health platform grounded in genetics.3. Understanding the Science: Genetic and Epigenetic TestingExplore whole-genome sequencing, pharmacogenomics, and the endocannabinoid system as tools for decoding behavioral predispositions.4. Primary, Secondary & Ancillary Behavior PatternsLearn how inherited markers influence emotional dysregulation, coping strategies, identity confusion, and systemic trauma suppression.5. Ethics & Application in Trauma-Informed TherapyDiscover how to ethically and effectively introduce DNA insights into the therapy room—balancing science with empathy and agency.6. Integrative Takeaways: How Genetic Insight Enhances HealingWe wrap up with three applied strategies for integrating epigenetic knowledge into personalized, trauma-informed care.Core Episode Insights:Your DNA is not your destiny. Most genes are probabilistic, not deterministic—and can be modulated by behavior, context, and therapeutic support.Inherited trauma is real. Epigenetic markers can transmit stress responses, dysregulation, and trauma susceptibility across generations.Precision therapy is the future. Integrating genetic and behavioral data allows for more ethical, informed, and individualized treatment—especially in cases of misdiagnosed or treatment-resistant conditions.Pop psychology isn't enough. Healing requires moving beyond mindset fixes and into somatic and biological awareness.The story of healing is written in both memory and molecules.Featured Guest:Len May – Founder and CEO of EndoDNAAn expert in the field of precision behavioral health, Len holds multiple patents in using DNA to guide wellness and mental health interventions. His platform provides clinicians with evidence-based, whole-genome insights to support trauma-informed treatment and pharmacogenomic alignment.Host: Jeffrey Besecker – Behavioral Coach and Host of The Light Inside Episode Credits:Executive Producer: Jeffrey BeseckerWritten by: Anna GetzGuest Booking & Research: The Light Inside Podcast TeamMusic & Audio Engineering: Light Inside StudiosOriginal Episode Concept and Research Framework: The Light Inside Think TankRelated Resources & Links:Len May & EndoDNA → www.endodna.comCall to Action:If you're a trauma-informed therapist, coach, or mental health professional, this episode will expand your understanding of the unseen forces shaping your clients' behaviors—and give you new tools to meet them where they truly are.Leave us a review if this conversation sparked a new insight into your practice.
Hannah Went is the Co-Founder of TruDiagnostic, a leading health data company and CLIA-certified laboratory that specializes in epigenetic testing and research.. Hannah is also the creator and host of the Everything Epigenetics Podcast. She is a molecular biologist by day and content creator by night and speaks with the most knowledgeable physicians and researchers in the world. Hannah is passionate about empowering people to take control of their health and wellness, and to discover new ways to enhance their overall performance. Epigenetic Experts & Aging Authorities At TruDiagnostic, we are firm believers that harnessing the power of epigenetic data can help the world live longer and healthier lives! We are a group of innovative doctors, researchers, clinicians, molecular biologists, biotechnology leaders, and diagnostic professionals. LEARN MORE, ORDER: https://www.trudiagnostic.com/ LISTEN TO FULL PODCDAST EPISODE: https://conciergemedicinetoday.net/podcast About Our Guest, Hannah Went, Co-Founder | TruDiagnostic Hannah has a lifelong passion for longevity and breakthrough, disruptive technologies that drive radical improvement to the human condition. She attended the University of Kentucky and graduated with a degree in Biology. During that time, she had multiple research internships studying cell signaling and cell biology. After graduation, she worked for the International Peptide Society as their Director of Research and Content. Through work in the integrative medicine industry, Hannah saw an opportunity for methylation based age diagnostics and started TruDiagnostic in 2020. TruDiagnostic is a company focusing on methylation array-based diagnostics for life extension and preventive healthcare serving functional medicine providers. TruDiagnostic has a commitment to research with over 30 approved clinical trials investigating the epigenetic methylation changes of longevity and health interventions. Since TruDiagnostic's inception, they have created one of the largest private epigenetic health databases in the world with over 75,000 patients tested to date. Hannah has since created Everything Epigenetics where she shares insights on how DNA regulation has an impact on your health. Connect with and Learn More about TruDiagnostic ... (https://www.trudiagnostic.com/)
Just about the hottest thing in longevity science right now is partial reprogramming - using Yamanaka factors to rewind the biological clock in our cells. Billion-dollar giants like Altos, Retro and New Limit are betting on it.But in this episode a far smaller player, Shift Bioscience, argues that the field may be looking in the wrong place. CEO Daniel Ives explains how his team used AI-powered virtual cells to uncover a single gene that seems to match OSK-level rejuvenation without the tumor risk that haunts classical reprogramming - and why their just-released data could change the game for aging research.
BUFFALO, NY — June 10, 2025 — A new #research perspective was #published in Aging (Aging-US) Volume 17, Issue 5, on May 5, 2025, titled “Methylation clocks for evaluation of anti-aging interventions.” In this perspective article, Dr. Josh Mitteldorf explores how current epigenetic clocks—used to estimate biological age—might mislead scientists trying to evaluate anti-aging therapies. The paper challenges a widespread assumption: that all changes in DNA methylation with age are equally valid for measuring biological decline. Dr. Mitteldorf proposes that failing to distinguish between different types of epigenetic changes could lead to inaccurate conclusions, potentially even favoring treatments that reduce repair processes rather than extend healthy lifespan. Methylation clocks have become a popular tool in aging research. These clocks use patterns of DNA methylation, a form of gene regulation that changes over time, to predict a person's biological age. Because human aging trials are long and expensive, these clocks offer a faster way to evaluate whether a therapy slows or reverses aging. However, this article warns that not all methylation changes are equal in meaning or effect. The perspective identifies two main categories of methylation changes that occur with age. One type, called 'Type 1,' seems to support the idea that aging may be programmed, with gene activity changing in ways that could cause damage, such as more inflammation or increased cell loss. The second type, “Type 2,” involves increased gene activity aimed at repairing age-related damage. If a therapy reduces the activity of Type 2 genes, it may appear to slow aging while actually interfering with the body's repair response. “Paradoxically, an intervention that “sets back” the body's methylation clock to a younger state is shutting off vital repair mechanisms, so it is likely inimical to health and longevity.” This distinction is important because most methylation clocks, including popular models like GrimAge, do not separate these two types. As a result, they may incorrectly suggest that a treatment is reversing aging when it is only suppressing beneficial repair mechanisms. According to Dr. Mitteldorf, this could lead researchers to draw the wrong conclusions and unintentionally slow down progress in anti-aging research. The author also addresses a growing trend in the scientific community that aims to explain age-related methylation as random drift rather than directed change. In a pilot analysis using publicly available data, Dr. Mitteldorf attempted to construct a clock based purely on stochastic, or random, changes. The results showed a weak correlation with age, suggesting that random drift is an unreliable basis for assessing biological aging. Dr. Mitteldorf argues that most age-related methylation changes are likely intentional and regulated, rather than random. If so, epigenetic clocks must be refined to reflect the biological purpose behind methylation shifts. Without distinguishing between changes that indicate damage and those that indicate repair, current clocks may not only mismeasure age but also misguide intervention strategies. This article highlights the urgent need to improve how methylation data are interpreted before such clocks can reliably assess anti-aging therapies. A clearer understanding of these molecular patterns could help reshape the future of aging research and therapy evaluation. DOI - https://doi.org/10.18632/aging.206245 Corresponding author - Josh Mitteldorf - aging.advice@gmail.com To learn more about the journal, please visit our website at https://www.Aging-US.com. MEDIA@IMPACTJOURNALS.COM
In this episode of the Epigenetics Podcast, we talked with Petra Hajkova from the MRC Laboratory of Medical Sciences about her work on epigenetics research on mammalian development, highlighting DNA methylation, histone modifications, and TET enzymes, along with her journey in molecular genetics and future research on epigenetic maintenance. Dr. Hajkova's early work focused on DNA methylation and resulted in innovative collaboration that allowed her to develop bisulfide sequencing techniques. We discuss her transition to the UK, where she began working in Azim Surani's lab at the University of Cambridge. Dr. Hajkova describes the excitement of researching chromatin dynamics in the mouse germline, leading to significant findings published in Nature. Her story highlights the intense yet rewarding nature of postdoctoral research as she navigated the complexities of working with embryos for the first time. As her research progressed, Dr. Hajkova established her own lab at the MRC London Institute of Medical Sciences, where she became a professor in 2017. We delve into her investigations on the differences between embryonic stem cells and embryonic germ cells regarding their distinct developmental origins. Dr. Hajkova outlines the challenges she faced in understanding the mechanisms behind global DNA demethylation in germline cells and the role of hydroxymethylation during early development. The discussion further covers her exciting findings regarding the specific functions of TET enzymes and their regulatory roles in maintaining epigenetic states. We explore her recent research published in Nature, which provides insights into the transition from primordial germ cells to gonocytes, emphasizing the significance of various epigenetic mechanisms in germline development. References Hajkova P, Ancelin K, Waldmann T, Lacoste N, Lange UC, Cesari F, Lee C, Almouzni G, Schneider R, Surani MA. Chromatin dynamics during epigenetic reprogramming in the mouse germ line. Nature. 2008 Apr 17;452(7189):877-81. doi: 10.1038/nature06714. Epub 2008 Mar 19. PMID: 18354397; PMCID: PMC3847605. Hajkova P, Jeffries SJ, Lee C, Miller N, Jackson SP, Surani MA. Genome-wide reprogramming in the mouse germ line entails the base excision repair pathway. Science. 2010 Jul 2;329(5987):78-82. doi: 10.1126/science.1187945. PMID: 20595612; PMCID: PMC3863715. Hill PWS, Leitch HG, Requena CE, Sun Z, Amouroux R, Roman-Trufero M, Borkowska M, Terragni J, Vaisvila R, Linnett S, Bagci H, Dharmalingham G, Haberle V, Lenhard B, Zheng Y, Pradhan S, Hajkova P. Epigenetic reprogramming enables the transition from primordial germ cell to gonocyte. Nature. 2018 Mar 15;555(7696):392-396. doi: 10.1038/nature25964. Epub 2018 Mar 7. PMID: 29513657; PMCID: PMC5856367. Huang TC, Wang YF, Vazquez-Ferrer E, Theofel I, Requena CE, Hanna CW, Kelsey G, Hajkova P. Sex-specific chromatin remodelling safeguards transcription in germ cells. Nature. 2021 Dec;600(7890):737-742. doi: 10.1038/s41586-021-04208-5. Epub 2021 Dec 8. PMID: 34880491. Related Episodes Epigenetic Mechanisms of Mammalian Germ Cell Development (Mitinori Saitou) Epigenetic Reprogramming During Mammalian Development (Wolf Reik) DNA Methylation and Mammalian Development (Déborah Bourc'his) Contact Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com
Michael Ringel is the Chief Operating Officer of Life Biosciences, a biotechnology company pioneering cellular rejuvenation therapies to reverse and prevent multiple diseases of aging. Michael became COO of Life just a few months ago, but he's been advising the company since 2018. Prior to this year, he was managing director and senior partner at Boston Consulting Group (BCG), where over a 25-year career he focused on R&D and innovation initiatives across the private sector and government. He earned his PhD in biology at Imperial College London and a JD from Harvard Law, and has become an active and highly respected member of the global longevity biotech community.In this episode, Chris and Michael explore Life Biosciences' groundbreaking approach to partial epigenetic reprogramming - the "holy grail" technology that could transform how we age at cellular, tissue, and organism levels. They discuss how this approach taps into the same biology that makes babies young, Life's lead therapeutic candidate ER-100 for eye diseases, and the "pipeline in a pill" concept at the core of the geroscience hypothesis: the idea that enable single interventions based on longevity science could treat multiple age-related diseases simultaneously.The Finer Details:The biology behind partial epigenetic reprogramming and how it differs from full reprogramming to pluripotencyWhy Michael considers partial reprogramming the "holy grail" of longevity interventionsLife Biosciences' lead candidate ER-100 for glaucoma and NAION (non-arteritic anterior ischemic optic neuropathy)The innovative inducible system that allows the therapy to be turned on and off with doxycyclineWhy the eye represents an ideal starting point for reprogramming therapiesThe "pipeline in a pill" concept and geroscience hypothesis - how single interventions could treat multiple age-related diseasesParallels between the emerging longevity field and the massive GLP-1 drug market that many pharma companies missedThe role of philanthropic investment in advancing fundamental longevity researchEvolutionary theories of aging and why aging should be easily manipulableTimeline expectations for moving from single disease treatments to whole-body rejuvenationLinksLife Biosciences company websiteMichael Ringel's ARDD talk
OsteoBites welcomes Yingqi Hua, MD from Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine to discuss his work on molecular subtyping of osteosarcoma, ecDNA, and more.Dr. Hua has been engaged in basic and clinical research of malignant bone tumors for more than 10 years, focusing on the individualized comprehensive treatment of advanced bone tumors, and is committed to transforming research results through clinical research. His research interests include 1. Multi-omics study of osteosarcoma: Multi-omics analysis identifies osteosarcoma subtypes with distinct prognosis indicating stratified treatment. 2. Epigenetic study of bone tumors: the function of histone mutation and the function of different histone methylation modification. 3. Drug screen: Screening sensitive drugs by patient derived xenograft(PDX) and explore the mechanism of drug action. 4. Clinical trial of advanced stage sarcomas based on precision medicine.
In this episode of the Epigenetics Podcast, we talked with Ani Deshpande from Sanford Burnham Prebys about his work on epigenetic regulation and developing small molecules through high throughput screens for AML. Throughout our discussion, we delve into Dr. Despande's journey into the field of biology and science, tracing his evolution from a literature enthusiast in Mumbai to a dedicated cancer researcher. He reflects on his formative experiences during his PhD at Ludwig Maximilian University in Munich, where she developed murine models for refractory acute myeloid leukemia (AML). We examine these models' contributions to therapeutic discovery and understanding the intricate mechanisms underscoring AML's complexities. Transitioning to his postdoctoral work at Scott Armstrong's lab in Boston, Dr. Despande shares his insights on the importance of epigenetic regulators, such as DOT1L, in leukemias, and how they can serve as strategic therapeutic targets. His ambitious pursuit of translational research is further highlighted through his efforts in developing a conditional knockout mouse model and his collaborative work utilizing CRISPR technology to refine our understanding of epigenetic regulation in cancer pathogenesis. Moreover, we engage in a conversation about the challenges and opportunities that arise when establishing his lab at Sanford Burnham Prebys. Dr. Despande candidly discusses the delicate balance between pursuing topics of genuine interest versus adhering to grant fundability, underlining the tension researchers face in the current scientific landscape. His emphasis on the critical need for innovation within lab settings serves as a motivational call for emerging scientists to venture beyond the established templates that often inhibit groundbreaking discoveries. We conclude our dialogue with an exploration of his recent projects, which involve targeting specific epigenetic modifiers and how his lab's findings can contribute to greater understanding and potential treatments for not only AML but also other pediatric cancers driven by gene fusions. Dr. Despande's insights into the integration of modern technologies, such as CRISPR libraries, exemplify his commitment to pushing the boundaries of cancer research. In addition to discussing his scientific contributions, we touch upon Dr. Despande's foray into podcasting (The Discovery Dialogues), shedding light on his motivation to bridge the communication gap between scientists and the broader public. He articulates his desire to demystify scientific discoveries and promote awareness about the intricate journey of research that lays the groundwork for medical advancements. This multidimensional discussion not only highlights his scientific achievements but also emphasizes the importance of effective science communication in fostering public understanding and appreciation of research. References Deshpande AJ, Cusan M, Rawat VP, Reuter H, Krause A, Pott C, Quintanilla-Martinez L, Kakadia P, Kuchenbauer F, Ahmed F, Delabesse E, Hahn M, Lichter P, Kneba M, Hiddemann W, Macintyre E, Mecucci C, Ludwig WD, Humphries RK, Bohlander SK, Feuring-Buske M, Buske C. Acute myeloid leukemia is propagated by a leukemic stem cell with lymphoid characteristics in a mouse model of CALM/AF10-positive leukemia. Cancer Cell. 2006 Nov;10(5):363-74. doi: 10.1016/j.ccr.2006.08.023. PMID: 17097559. Deshpande AJ, Deshpande A, Sinha AU, Chen L, Chang J, Cihan A, Fazio M, Chen CW, Zhu N, Koche R, Dzhekieva L, Ibáñez G, Dias S, Banka D, Krivtsov A, Luo M, Roeder RG, Bradner JE, Bernt KM, Armstrong SA. AF10 regulates progressive H3K79 methylation and HOX gene expression in diverse AML subtypes. Cancer Cell. 2014 Dec 8;26(6):896-908. doi: 10.1016/j.ccell.2014.10.009. Epub 2014 Nov 20. PMID: 25464900; PMCID: PMC4291116. Sinha S, Barbosa K, Cheng K, Leiserson MDM, Jain P, Deshpande A, Wilson DM 3rd, Ryan BM, Luo J, Ronai ZA, Lee JS, Deshpande AJ, Ruppin E. A systematic genome-wide mapping of oncogenic mutation selection during CRISPR-Cas9 genome editing. Nat Commun. 2021 Nov 11;12(1):6512. doi: 10.1038/s41467-021-26788-6. Erratum in: Nat Commun. 2022 May 16;13(1):2828. doi: 10.1038/s41467-022-30475-5. PMID: 34764240; PMCID: PMC8586238. Related Episodes Targeting COMPASS to Cure Childhood Leukemia (Ali Shilatifard) The Menin-MLL Complex and Small Molecule Inhibitors (Yadira Soto-Feliciano) MLL Proteins in Mixed-Lineage Leukemia (Yali Dou) Contact Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com
BUFFALO, NY — May 20, 2025 — A new #research paper was #published in Aging (Aging-US) Volume 17, Issue 4, on April 17, 2025, titled “Dietary associations with reduced epigenetic age: a secondary data analysis of the methylation diet and lifestyle study.” In this study, researchers led by first author Jamie L. Villanueva from the University of Washington and the National University of Natural Medicine, along with corresponding author Ryan Bradley from the National University of Natural Medicine and University of California, investigated how diet influences epigenetic aging. They found that certain plant-based foods containing natural compounds called methyl adaptogens were associated with a decrease in epigenetic age. This effect was measured using DNA methylation, a marker that reflects how the body ages at the cellular level. The findings suggest that targeted food choices may help slow the aging process. Epigenetic age refers to how old a person's cells appear biologically, rather than their actual age in years. DNA methylation patterns, which are chemical tags on DNA, can indicate whether someone is aging faster or slower than expected. For this study, researchers used Horvath's epigenetic clock, a widely accepted tool, to measure changes in epigenetic age. The analysis included healthy men aged 50 to 72 who had previously completed an eight-week program featuring a plant-based, nutrient-rich diet, along with guidance on exercise, sleep, and stress management. Researchers focused on individual dietary differences to understand why some participants experienced greater improvements in epigenetic age than others. The study found that those who ate higher amounts of methyl adaptogen foods—including turmeric, rosemary, garlic, berries, green tea, and oolong tea—experienced greater reductions in epigenetic age. These benefits remained significant even after accounting for weight changes and participants' starting epigenetic age, suggesting that the foods themselves had a direct impact on aging markers. “In hierarchical linear regression, foods investigated as polyphenolic modulators of DNA methylation (green tea, oolong tea, turmeric, rosemary, garlic, berries) categorized in the original study as methyl adaptogens showed significant linear associations with epigenetic age change (B = -1.21, CI = [-2.80, -0.08]), after controlling for baseline epigenetic age acceleration and weight changes.” The natural compounds in methyl adaptogen foods are known to influence how genes behave by affecting DNA methylation. Previous studies have shown that these compounds may support healthy aging and help lower the risk of conditions such as heart disease and cognitive decline. While this study involved a relatively small group of middle-aged men, it adds knowledge to growing global research showing that diets rich in polyphenols—found in vegetables, fruits, and teas—are associated with slower aging. These findings support earlier results from studies on Mediterranean and traditional Japanese diets, both known for their health benefits. Future research should include larger and more diverse populations and use updated epigenetic aging tools to confirm these results. Based on current evidence, this study highlights a practical, food-based strategy that may help reduce epigenetic aging and support long-term health. DOI - https://doi.org/10.18632/aging.206240 Corresponding author - Ryan Bradley - rbradley@nunm.edu To learn more about the journal, connect with us on social media at: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM
Exposure to inorganic arsenic before conception can trigger changes in gene activity that are passed down to offspring and increase their risk of developing diabetes, according to a study in mice funded by an NIEHS individual research grant and by the NIEHS Superfund Research Program. These changes, known as epigenetic changes, alter how genes work without changing the genes themselves. In this study, the researchers looked at a type of change called CpG methylation.
In this episode Dr. Raffaele Teperino shares insights from his ongoing research focused on developmental programming, particularly how paternal health before conception influences not only offspring health but also maternal health outcomes. As we trace his academic journey from studying biotechnology and pharmacology to leading his own lab, Dr. Teperino reflects on his early fascination with medicine, the pivotal experiences that shaped his career, and the integration of epigenetics into understanding metabolic diseases. We discuss the nuances of epigenetics—going beyond simple chromatin biology to examine its wider implications on phenotypic variation. Dr. Teperino emphasizes his approach of modeling relevant physiological phenomena in the lab to better understand the underlying mechanisms driving conditions like obesity and metabolic disruption. A particular focus is placed on his experiences during his postdoctoral years, where he investigated the developmental pathways of hedgehog signaling and its metabolic implications in adipogenesis. Our talk shifts towards the practical implications of his research, highlighting recent investigations into how circadian rhythms and paternal lifestyles influence offspring health. Dr. Teperino reveals his findings on how disturbances in circadian rhythms can lead to intergenerational health issues, showcasing the surprising effects observed in offspring of fathers experiencing circadian misalignment. We delve into the significance of seminal fluid as a potential medium for intergenerational transfer of stress responses, examining the role of stress hormones and their impacts on fetal development. As we explore a fascinating recent study highlighting the impact of paternal diets on future generations, Dr. Teperino underscores the importance of understanding the shorter exposure periods sufficient to trigger these health changes. He presents data that links paternal obesity and preconception health to an increased risk of obesity and insulin resistance in children, challenging traditional narratives around maternal responsibility for offspring health. References Darr J, Tomar A, Lassi M, Gerlini R, Berti L, Hering A, Scheid F, Hrabě de Angelis M, Witting M, Teperino R. iTAG-RNA Isolates Cell-Specific Transcriptional Responses to Environmental Stimuli and Identifies an RNA-Based Endocrine Axis. Cell Rep. 2020 Mar 3;30(9):3183-3194.e4. doi: 10.1016/j.celrep.2020.02.020. PMID: 32130917. Lassi M, Tomar A, Comas-Armangué G, Vogtmann R, Dijkstra DJ, Corujo D, Gerlini R, Darr J, Scheid F, Rozman J, Aguilar-Pimentel A, Koren O, Buschbeck M, Fuchs H, Marschall S, Gailus-Durner V, Hrabe de Angelis M, Plösch T, Gellhaus A, Teperino R. Disruption of paternal circadian rhythm affects metabolic health in male offspring via nongerm cell factors. Sci Adv. 2021 May 26;7(22):eabg6424. doi: 10.1126/sciadv.abg6424. PMID: 34039610; PMCID: PMC8153725. Tomar A, Gomez-Velazquez M, Gerlini R, Comas-Armangué G, Makharadze L, Kolbe T, Boersma A, Dahlhoff M, Burgstaller JP, Lassi M, Darr J, Toppari J, Virtanen H, Kühnapfel A, Scholz M, Landgraf K, Kiess W, Vogel M, Gailus-Durner V, Fuchs H, Marschall S, Hrabě de Angelis M, Kotaja N, Körner A, Teperino R. Epigenetic inheritance of diet-induced and sperm-borne mitochondrial RNAs. Nature. 2024 Jun;630(8017):720-727. doi: 10.1038/s41586-024-07472-3. Epub 2024 Jun 5. PMID: 38839949; PMCID: PMC11186758. Related Episodes The Impact of Paternal Diet on Offspring Metabolism (Upasna Sharma) Transgenerational Inheritance and Evolution of Epimutations (Peter Sarkies) The Role of Small RNAs in Transgenerational Inheritance in C. elegans (Oded Rechavi) Contact Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com
Too busy to read the Lens? Listen to our weekly summary here! In this week's issue we discuss:Epigenetic aging alone, as established by DNA methylation studies, correlates with faster glaucoma progression independent of IOP. Repeated low-level red light (RLRL) therapy can delay myopia progression and axial elongation in children, but new research shows it can lead to ganglion cell damage and cone photoreceptor loss.Pegcetocoplan treatment reduces vision loss in the fovea and junctional zone in patients with geographic atrophy, per microperimetry analysis.
ReferencesCureus.2023 Nov 27;15(11):e49521Cell Reports Medicine2024 V5, Issue 91017 28 September 17, Am J Physiol Endocrinol Metab.2013 Feb 12;304(8):E789–E799Guerra, DJ 2025 Unpublished lectures Nardini, Veracini, and Locatelli. 1740's. Violin Sonatas.https://open.spotify.com/album/1bVy95FlClPhHgUMEurvhz?si=VEr5xm4oRB6zGwGwtIAAWg
referencesCureus. 2023 Nov27;15(11):e49521Cell Reports Medicine 2024 V5, Issue 91017 28 September 17, Nature Communications | (2022) 13:6781Cancer Cell. 2020 Jul 9;38(2):167–197.Am J Physiol Endocrinol Metab.2013 Feb 12;304(8):E789–E799.Hunter/Garcia et al.1975. "Blues for Allah" lp. Grateful Dead.https://open.spotify.com/album/5BwjVdVJ4aOmbIYomznfCv?si=1k4STRnoR4SAxG3DVrO0IAHaydn, M. "Requiem in C Minorhttps://open.spotify.com/album/0lr5buO8BDuJGQhBeTgzfR?si=HLCnU3JBSKu596rKZ96eiQ
ReferencesActa Pharm Sin B. 2022 Dec;12(12):4390-4406Cell Death Discov . 2023 Dec 12;9:451.JBC 1997. Volume 272, Issue 36p22432-22437SeptemberCell Metab. 2012 Jun 6;15(6):813–826.Int J Mol Sci. 2022 May 26;23(11):5978Hayward, J. 1967. "The Afternoon " from: Days of future Passed lp.https://open.spotify.com/track/4uCFK6Lm1gA3MaIbSRhIfS?si=48ccbe6f079e469fMcQuinn, R. 1970. "Pale Blue" Byrds lp :Byrdmaniax.https://open.spotify.com/track/46D9uj48T6E8xlSKLv4cEU?si=495da777c73c4929Mozart, WA. 1788. Divertimento in E flat Major. K 563https://open.spotify.com/album/5yxpvtJJTlKUMtUtl9nBcm?si=zc_K0IlzRqOzVVatZs_Pkw
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ReferencesJournal of Biological Chemistry 2013. 28.8 52 :37355-37364 Neuro Oncol . 2020 Mar5;22(3):333-344.Front. Cell. Neurosci., 2018 27 NovemberCell Metabolism 2016. Volume 23, Issue 2, Pages 303-314JBC in Press 2025. 10854. 4April. Mydland, B. 1989. "I will Take You Home" Grateful Deadhttps://open.spotify.com/track/1Q3AmIjEbPYemA6UkjUUu0?si=3301b3057df94e04Joel, B. 1979. "Until the Night"https://open.spotify.com/track/3UzWjLQVzCG60gwJdApLqI?si=c0a9ded856c941cdSimon, P. 1965. "April Come She Will"https://open.spotify.com/track/0djZ2ndRfAL69WYNra5jRC?si=da8581de131448b2Mozart, WA. 1787. et al. Symphony 25 K.183 in G minor , plus symphonies 28, and 29https://open.spotify.com/album/3qhUJTpkFjDeM49QidGMQb?si=iUpvUWNfSlyWGSzgvjDKLg
In this episode of the Epigenetics Podcast, we talked with Dr. Frank Johannes from the Technical University of Munich in Freising about his work on evolutionary clocks and epigenetic inheritance in plants. In this episode we discuss Dr. Johannes pursuits in understanding how heritable epigenetic variations, particularly through DNA methylation, affect phenotypic diversity in plants. He shared insights about groundbreaking research initiatives he has led, including one of the first population epigenetic studies in plants that effectively linked heritable DNA methylation changes to critical traits like flowering time and root length. This work underscored the importance of epigenetic factors that extend beyond traditional genetic sequences, illustrating a significant shift in how we comprehend inheritance and trait variation in organisms. As we dug deeper into the science, we examined Dr. Johannes's innovative approaches to studying chromatin-based mechanisms of genome regulation, allowing for a nuanced understanding of epigenetic inheritance. His lab's extensive phenotyping of Arabidopsis plants highlighted how inducing heritable variations in DNA methylation could lead to significant trait outcomes – results that have substantial implications for agriculture and understanding complex characteristics across generations. The dialogue continued to unravel the dynamics between forward and backward epimutations, delving into their heritable nature and their rapid accumulation compared to traditional genetic mutations. Dr. Johannes overturned conventional understanding by presenting epigenetic processes that are not as static as once thought, providing compelling evidence that these spontaneous changes could inform evolutionary clocks; a concept that offers new avenues for studying the relationships between species over relatively short timeframes. Moreover, we discussed the exciting concept of epigenetic clocks, which play a role in assessing the age of various species, including trees. The potential applications for such clocks in environmental management and the assessment of tree vitality further illuminated the practical impacts of Dr. Johannes's research. These insights also pave the way for sophisticated non-invasive methods of understanding plant biology, which can revolutionize forest management practices in the face of climate change and other ecological pressures. References Colomé-Tatché M, Cortijo S, Wardenaar R, Morgado L, Lahouze B, Sarazin A, Etcheverry M, Martin A, Feng S, Duvernois-Berthet E, Labadie K, Wincker P, Jacobsen SE, Jansen RC, Colot V, Johannes F. Features of the Arabidopsis recombination landscape resulting from the combined loss of sequence variation and DNA methylation. Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16240-5. doi: 10.1073/pnas.1212955109. Epub 2012 Sep 17. PMID: 22988127; PMCID: PMC3479620. Cortijo S, Wardenaar R, Colomé-Tatché M, Gilly A, Etcheverry M, Labadie K, Caillieux E, Hospital F, Aury JM, Wincker P, Roudier F, Jansen RC, Colot V, Johannes F. Mapping the epigenetic basis of complex traits. Science. 2014 Mar 7;343(6175):1145-8. doi: 10.1126/science.1248127. Epub 2014 Feb 6. PMID: 24505129. van der Graaf A, Wardenaar R, Neumann DA, Taudt A, Shaw RG, Jansen RC, Schmitz RJ, Colomé-Tatché M, Johannes F. Rate, spectrum, and evolutionary dynamics of spontaneous epimutations. Proc Natl Acad Sci U S A. 2015 May 26;112(21):6676-81. doi: 10.1073/pnas.1424254112. Epub 2015 May 11. PMID: 25964364; PMCID: PMC4450394. Yao N, Zhang Z, Yu L, Hazarika R, Yu C, Jang H, Smith LM, Ton J, Liu L, Stachowicz JJ, Reusch TBH, Schmitz RJ, Johannes F. An evolutionary epigenetic clock in plants. Science. 2023 Sep 29;381(6665):1440-1445. doi: 10.1126/science.adh9443. Epub 2023 Sep 28. PMID: 37769069. Related Episodes Transgenerational Inheritance and Epigenetic Imprinting in Plants (Mary Gehring) Epigenetic Clocks and Biomarkers of Ageing (Morgan Levine) Contact Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com
BUFFALO, NY — April 23, 2025 — A new #research paper was #published in Aging (Aging-US) Volume 17, Issue 3, on March 18, 2025, titled “Epigenetic and accelerated age in captive olive baboons (Papio anubis), and relationships with walking speed and fine motor performance.” In this study, led by Sarah J. Neal from The University of Texas MD Anderson Cancer Center, researchers examined how the epigenetic age of baboons—a measure of biological aging based on DNA methylation—compared to their actual age (chronological age) and whether it related to signs of aging like slower walking or reduced hand coordination. While many baboons showed a mismatch between their epigenetic and chronological ages, these differences did not consistently align with physical performance measures. Researchers analyzed blood samples from 140 captive olive baboons (Papio anubis) to determine whether these primates, like humans, show signs of “age acceleration”—a condition where epigenetic age surpasses chronological age. The results revealed that about a quarter of the baboons exhibited accelerated aging, while another quarter showed signs of slower aging, known as “age deceleration.” “We found that epigenetic age was strongly correlated with chronological age, and that approximately 27% of the sample showed age acceleration and 28% showed age deceleration." The scientists then investigated whether these differences were reflected in physical indicators such as walking speed or fine motor skills. To do this, researchers measured walking speed by tracking how quickly baboons moved between points in their enclosures and assessed fine motor skills using a simple task that involved picking up small objects. Older baboons did tend to walk more slowly and perform worse on tasks requiring dexterity, patterns also seen in aging humans. However, these changes were more closely related to chronological age than epigenetic age. Two different methods were used to measure the gap between epigenetic and chronological age. Each method produced slightly different outcomes, highlighting the complexity of defining age acceleration. In one analysis, the oldest baboons appeared to age more slowly epigenetically, possibly reflecting selective survival, where only the healthiest individuals live into old age. This research is among the first to classify baboons based on their epigenetic aging rate and investigate how this links to real-world signs of aging. Although the findings did not provide clear evidence that epigenetic age acceleration leads to physical decline, they point to the importance of DNA methylation as a biomarker in aging research. Because baboons share many biological similarities with humans, these findings help refine how researchers measure aging and assess potential early warning signs of decline. Continued studies in baboons and other primates may improve our understanding of how epigenetic aging influences health and longevity—and could help develop better tools for predicting age-related decline in humans. DOI - https://doi.org/10.18632/aging.206223 Corresponding author - Sarah Neal - SJNeal@MDAnderson.org Video short - https://www.youtube.com/watch?v=EFfRMFbAMqk Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206223 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts To learn more about the journal, please visit our website at https://www.Aging-US.com and connect with us on social media at: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM
What if aging isn't just inevitable—but modifiable? In this episode of Longevity Roadmap, Dr. Matt Kaeberlein breaks down the science of biological aging, with a focus on mTOR, epigenetics, and the hallmarks of aging like cellular senescence, mitochondrial dysfunction, and epigenetic drift. He explores the role of genetics vs. environment, the promise and pitfalls of metformin, NAD boosters, and senolytics, and why interventions like rapamycin and caloric restriction may extend health span. From the limitations of biological age tests to the importance of lean muscle mass, this conversation is a masterclass in evidence-based longevity research. Watch the full episode to understand the mechanisms of aging—and what current science says about slowing them down. Learn more about Dr. Matt Kaeberlein and Optisan: https://www.optispan.life/ - Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0 Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com/
In this thought-provoking episode of Keeping Abreast, I sit down with Dr. Nathan Goodyear, a board-certified physician who left conventional oncology to become a pioneer in integrative cancer care. Together, they explore the limitations of traditional treatment models and why the current “war on cancer” mentality may be doing more harm than good.Dr. Goodyear opens up about his personal journey from a traditional medical background to becoming a patient himself—an experience that radically changed his approach to healing. He and Dr. Jenn unpack the deeper truths about cancer: its roots in immune dysfunction, the influence of lifestyle and environment, and the transformative power of epigenetics.This episode doesn't shy away from controversy—from the politicization of medicine to the potential of off-label and repurposed drugs like ivermectin and metformin. It's a bold, necessary conversation about empowering patients, reimagining cancer care, and building a future where treatment is rooted in innovation, integrity, and true healing.In This Episode, You Will Learn:Dr. Goodyear's personal health crisis inspired a complete shift in his approach to cancer care.The “fight” against cancer often becomes a fight against the body—integrative medicine aims to heal, not battle.Cancer is part of the immune system—understanding that changes everything.Cryoablation offers a powerful, less invasive alternative to surgery with promising outcomes.Lifestyle, stress, diet, and toxins play a critical role in cancer development and recurrence.Epigenetic changes can pass through generations, altering cancer risk.Mammograms may not be as protective as once believed—and may lead to overtreatment.The healthcare system often incentivizes drugs over real healing.Repurposed medications like metformin and ivermectin show powerful anti-cancer potential.The term “quack” is weaponized to discredit innovative doctors who challenge the norm.
In this episode, I'm joined by the brilliant Dr. Piper Gibson, and let me tell you, this conversation is packed with insight, truth bombs, and hope for anyone dealing with chronic health issues that feel confusing, overwhelming, or unsolvable.Dr. Gibson is an epigenetics expert, a functional medicine practitioner, and the founder of Elite Gene Labs and the Tic Disorder Institute. She brings years of experience working with families, especially those navigating tic disorders, anxiety, ADHD, autoimmune symptoms, and chronic inflammation. We dive into how our genetics and environment interact, how symptoms are often signals (not life sentences), and what's actually possible when we start asking better questions.We talk about:Why so many kids are being dismissed with “they'll grow out of it” and why that's not good enoughWhat tic disorders really are and how to decode themThe critical role inflammation and gut health play in anxiety, ADHD, and other neurological symptomsWhy genomic testing matters, how it works, and what it can actually tell youThe myth of “one-size-fits-all” health and how personalization changes everythingHow Dr. Piper's own son's health crisis led her to this work, and what she's learned from helping hundreds of families sinceIf you've ever felt dismissed by the system, overwhelmed by information online, or unsure of where to start, this episode is for you. Dr. Piper and I are both passionate about helping you feel seen, heard, and empowered to take control of your health in a real, personalized way.You are not broken. Your body is trying to talk to you. Let's start listening together.Learn more about Piper Gibson:Dr. Gibson founded the Tic Disorder Institute: Regenerating Health and Elite Gene Labs, where she empowers families and healthcare professionals to address tic disorders and optimize wellness. She is a Doctor of Functional Medicine, Advanced Holistic Nutrition, and a Board-Certified Doctor of Natural Medicine.Dr. Gibson helps individuals address the root of their symptoms through functional lab testing, nutrition, and genetic insights. She is also the author of Tic Talk: Common Misconceptions, Natural Approaches, and Real Conversations about Tic Disorders.RESOURCES:Connect with Piper Gibson:Facebook: https://www.facebook.com/RegeneratingHealthInstagram: https://www.instagram.com/regeneratinghealth/YouTube: https://www.youtube.com/@ticdisordersecretsShow Links:Visit the website: healthyawakening.co/podcastFind listening links here: https://healthyawakening.co/linksSHOW NOTES:healthyawakening.co/episode51Connect with Susan:Contact me for your DNA testing or epigenetic coaching!To schedule a FREE consultation, send an email to susan@healthyawakening.coFaceboook: https://www.facebook.com/susanP.S. Want reminders about episodes? Sign up for our newsletter, you can find the link on our podcast page! https://healthyawakening.co/podcast
Parent-specific epigenetic marks (imprints) leading to parent-specific gene expression are crucial for normal growth and development, yet their mechanisms of establishment and maintenance are not fully understood. In humans, approximately 200 imprinted genes have been discovered, and improper imprinting can manifest in growth restriction, obesity, intellectual disabilities, behavioral abnormalities, and an increased risk of certain cancers. While the use of pluripotent stem cells, especially those in the naïve state, have advanced aspects of modeling early development, a persistent issue hampering bona fide naïve hPSCs is the erosion of imprints. Our guests on today's episode will discuss genomic imprinting, its function, impact, and a new reporter system of imprinted gene expression in hPSCs that enables real-time visualization of loss-of-imprinting at single-cell resolution. This assay provides an important tool to help discover how to improve the imprint fidelity of naïve hPSCs and hence their application for studies of human development and regeneration. Guests Thorold Theunissen, PhD, Department of Developmental Biology, Washington University in St Louis, USA Gal Keshet, The Azrieli Center for Stem Cells and Genetic Research, The Hebrew University of Jerusalem, IsraelSupporting ContentTracking and mitigating imprint erasure during induction of naïve human pluripotency at single-cell resolutionHostJanet Rossant, Editor-in-Chief, Stem Cell Reports and The Gairdner FoundationAbout Stem Cell ReportsStem Cell Reports is the open access, peer-reviewed journal of the International Society for Stem Cell Research (ISSCR) for communicating basic discoveries in stem cell research, in addition to translational and clinical studies. Stem Cell Reports focuses on original research with conceptual or practical advances that are of broad interest to stem cell biologists and clinicians.X: @StemCellReportsAbout ISSCRWith nearly 5,000 members from more than 80 countries, the International Society for Stem Cell Research (@ISSCR) is the preeminent global, cross-disciplinary, science-based organization dedicated to stem cell research and its translation to the clinic. The ISSCR mission is to promote excellence in stem cell science and applications to human health.ISSCR StaffKeith Alm, Chief Executive OfficerYvonne Fisher, Managing Editor, Stem Cell ReportsKym Kilbourne, Director of Media and Strategic CommunicationsMegan Koch, Senior Marketing ManagerJack Mosher, Scientific AdvisorHunter Reed, Senior Marketing CoordinatorVoice WorkBen Snitkoff
Lesbians take on the United Nations https://blogs.lse.ac.uk/lsehistory/2025/02/26/lesbians-take-on-the-united-nations/https://www.troubleandstrife.org/articles/issue-33/lesbians-take-on-the-un/Memories of the 1996 International Conference on Violence, Abuse & Women's Citizenship https://brighton96.filia.org.uk/Gen Z need to drink more to save lesbian bars https://www.lgbtqnation.com/2025/03/gen-zers-dont-know-how-to-go-to-bars-are-lesbian-bars-in-danger/18 lesbian sports power couples who are winning at life and lovehttps://sports.yahoo.com/article/18-lesbian-sports-power-couples-203743549.htmlWould you do this? https://www.thecollegefix.com/gene-edit-lesbians-eggs-to-mimic-sperm-medical-journal-argues/ This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.thelesbianprojectpod.com/subscribe
This week, Jonathan is joined by Eytan Stein, Chief of the Leukaemia Service and an Attending Physician at Memorial Sloan Kettering Cancer Center, New York, USA. Timestamps: (00:00)-Introduction (01:05)-The current landscape of treatments (02:26)-The promise and peril of differentiation therapy (05:55)-Highlighting the most impactful clinical trials (08:38)-Epigenetics and the future of targeted therapies (10:40)-The BEAT AML master clinical trial (12:57)-The latest research into IDH inhibitors (16:10)-Therapies for splicing factor mutations (19:29)-Reducing patient fear with education (22:46)-Stein's three wishes for healthcare
Want to influence your biological age? Today's #WisdomWednesday reveals how your lifestyle choices act as "bookmarks" in your genetic instruction manual, determining which genes get activated or silenced as you age. From strategic exercise timing to specific superfoods, discover science-backed strategies that can help reprogram your genes for healthier aging. Plus, learn why your social connections might be just as important as your workout routine in keeping your genes young. Have a listen today.See omnystudio.com/listener for privacy information.
In this episode of the Epigenetics Podcast, we talked with Ferdinand von Meyenn from ETH Zürich about his work on the interplay of nutrition, metabolic pathways, and epigenetic regulation. To start Dr. Meyenn recounts his pivotal research on DNA methylation in naive embryonic stem cells during his time with Wolf Reick. He explains the dynamics of global demethylation in naive stem cells, revealing the key enzymes involved and the unexpected findings surrounding UHF1—its role in maintaining DNA methylation levels and influencing the methylation landscape during early embryonic development. Dr. Meyenn then shares his perspective on the scientific transition to establishing his own lab at ETH. He reflects on his ambitions to merge the fields of metabolism and epigenetics, which is a recurring theme throughout his research. By investigating the interplay between metabolic changes and epigenetic regulation, he aims to uncover how environmental factors affect cellular dynamics across various tissues. This leads to a discussion of his recent findings on histone lactylation and its implications in cellular metabolism, as well as the intricacies of epigenetic imprinting in stem cell biology. Last but not least we touch upon Dr. Meyenn's most recent study, published in Nature, investigating the epigenetic effects of obesity. He provides a detailed overview of how adipose tissue undergoes transcriptional and epigenetic rearrangements during weight fluctuations. The conversation highlights the notion of epigenetic memory in adipocytes, showing how obesity is not just a temporary state but leaves lasting cellular changes that can predispose individuals to future weight regain after dieting. This exploration opens avenues for potential therapeutic interventions aimed at reversing adverse epigenetic modifications. References von Meyenn, F., Iurlaro, M., Habibi, E., Liu, N. Q., Salehzadeh-Yazdi, A., Santos, F., Petrini, E., Milagre, I., Yu, M., Xie, Z., Kroeze, L. I., Nesterova, T. B., Jansen, J. H., Xie, H., He, C., Reik, W., & Stunnenberg, H. G. (2016). Impairment of DNA Methylation Maintenance Is the Main Cause of Global Demethylation in Naive Embryonic Stem Cells. Molecular cell, 62(6), 848–861. https://doi.org/10.1016/j.molcel.2016.04.025 Galle, E., Wong, C. W., Ghosh, A., Desgeorges, T., Melrose, K., Hinte, L. C., Castellano-Castillo, D., Engl, M., de Sousa, J. A., Ruiz-Ojeda, F. J., De Bock, K., Ruiz, J. R., & von Meyenn, F. (2022). H3K18 lactylation marks tissue-specific active enhancers. Genome biology, 23(1), 207. https://doi.org/10.1186/s13059-022-02775-y Agostinho de Sousa, J., Wong, C. W., Dunkel, I., Owens, T., Voigt, P., Hodgson, A., Baker, D., Schulz, E. G., Reik, W., Smith, A., Rostovskaya, M., & von Meyenn, F. (2023). Epigenetic dynamics during capacitation of naïve human pluripotent stem cells. Science advances, 9(39), eadg1936. https://doi.org/10.1126/sciadv.adg1936 Bonder, M. J., Clark, S. J., Krueger, F., Luo, S., Agostinho de Sousa, J., Hashtroud, A. M., Stubbs, T. M., Stark, A. K., Rulands, S., Stegle, O., Reik, W., & von Meyenn, F. (2024). scEpiAge: an age predictor highlighting single-cell ageing heterogeneity in mouse blood. Nature communications, 15(1), 7567. https://doi.org/10.1038/s41467-024-51833-5 Hinte, L. C., Castellano-Castillo, D., Ghosh, A., Melrose, K., Gasser, E., Noé, F., Massier, L., Dong, H., Sun, W., Hoffmann, A., Wolfrum, C., Rydén, M., Mejhert, N., Blüher, M., & von Meyenn, F. (2024). Adipose tissue retains an epigenetic memory of obesity after weight loss. Nature, 636(8042), 457–465. https://doi.org/10.1038/s41586-024-08165-7 Related Episodes Nutriepigenetics: The Effects of Diet on Behavior (Monica Dus) Epigenetic and Metabolic Regulation of Early Development (Jan Żylicz) Effects of Environmental Cues on the Epigenome and Longevity (Paul Shiels) Contact Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com
Do you know your biological age?
In this episode of the Epigenetics Podcast, we talked with Maxim Greenberg from the Institute Jacob Monot about his work on epigenetic consequences of DNA methylation in development. In this interview we explore how Dr. Greenbergs work at UCLA involved pioneering experiments on DNA methylation mechanisms and how this period was marked by significant collaborative efforts within a highly competitive yet supportive lab environment that ultimately lead to publications in high impact journals. His transition to a postdoctoral position at the Institut Curie with Deborah Bourc'his harnessed his newfound expertise in mammalian systems, examining chromatin changes and the implications for embryonic development. Dr. Greenberg explained the nuances of his research, particularly how chromatin modifications during early development can influence gene regulatory mechanisms later in life, providing a compelling narrative about the potential long-term impacts of epigenetic changes that occur in utero. Throughout our conversation, we examined the intricate relationship between DNA methylation and Polycomb repression, discussing how these epigenetic mechanisms interact and the functional outcomes of their regulation. Dr. Greenberg's insights into his recent studies reveal a commitment to unraveling the complexities of enhancer-promoter interactions in the context of epigenetic regulation. References Greenberg, M. V., Ausin, I., Chan, S. W., Cokus, S. J., Cuperus, J. T., Feng, S., Law, J. A., Chu, C., Pellegrini, M., Carrington, J. C., & Jacobsen, S. E. (2011). Identification of genes required for de novo DNA methylation in Arabidopsis. Epigenetics, 6(3), 344–354. https://doi.org/10.4161/epi.6.3.14242 Greenberg, M. V., Glaser, J., Borsos, M., Marjou, F. E., Walter, M., Teissandier, A., & Bourc'his, D. (2017). Transient transcription in the early embryo sets an epigenetic state that programs postnatal growth. Nature genetics, 49(1), 110–118. https://doi.org/10.1038/ng.3718 Greenberg, M., Teissandier, A., Walter, M., Noordermeer, D., & Bourc'his, D. (2019). Dynamic enhancer partitioning instructs activation of a growth-related gene during exit from naïve pluripotency. eLife, 8, e44057. https://doi.org/10.7554/eLife.44057 Monteagudo-Sánchez, A., Richard Albert, J., Scarpa, M., Noordermeer, D., & Greenberg, M. V. C. (2024). The impact of the embryonic DNA methylation program on CTCF-mediated genome regulation. Nucleic acids research, 52(18), 10934–10950. https://doi.org/10.1093/nar/gkae724 Richard Albert, J., Urli, T., Monteagudo-Sánchez, A., Le Breton, A., Sultanova, A., David, A., Scarpa, M., Schulz, M., & Greenberg, M. V. C. (2024). DNA methylation shapes the Polycomb landscape during the exit from naive pluripotency. Nature structural & molecular biology, 10.1038/s41594-024-01405-4. Advance online publication. https://doi.org/10.1038/s41594-024-01405-4 Related Episodes DNA Methylation and Mammalian Development (Déborah Bourc'his) Circulating Epigenetic Biomarkers in Cancer (Charlotte Proudhon) Epigenetic Mechanisms in Genome Regulation and Developmental Programming (James Hackett) Contact Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com
January is the peak season for divorce, depression, extreme autism and ADHD symptoms, anxiety and heaviness. Why? Because we show up with unhealed trauma-responses in December. That's what causes numbing out with food. That's what causes compulsive shopping and doormat-tendencies, hefty arguments and deep sadness when your child doesn't fit in, speak or behave and no one seems to help or understand you.You need rest for your body and soul during the holidays. I want to help you in this peaceful Holiday season podcast episode..You need rest for your body and soul during the holidays. You do NOT NEED what most people get in December:More expectations.More hyperactivity, meltdowns, tantrums and autism symptoms.More expenses.More trauma triggers.More stress and sadness.More sugar that weighs you down in January.More arguments with family members and dissapointment .More stuff.More food than your tired body can handle.In this podcast episode, Christian autism mom-coach Ninka-Bernadette Mauritson from Barefoot Autism warriors shares the best tools for a peaceful Holiday.Spiritual/Biblical tools & scripture for peace, love and healing family trauma.Epigenetic tools.Scientific tools to calm down your child and your nervous system.Food tips to avoid autism symtoms, meltdowns and triggers. Get her free Christmas food guide and neuro-provoking foodlist HERE.Here are 3 ways we can start turning autism symptoms around together, whenever you're ready... 1. Send me a voice message and get my feedback on your most pressing struggles. 2. Check out the free video series "The 5 hidden messages behind autism symptoms" and find your child's unique triggers. 3. Work with me privatelyIf you'd like to work with me directly to turn as many symptoms around as possible in my Autism Turnaround Coaching and implementation group..send me an email with "coaching" in the subject line and tell me how old your child is. I'll get you all the details.
Are you looking for ways to turn back the clock? As a specialist in anti-aging, regenerative, and functional medicine, Dr. Paziotopoulos incorporates a variety of disciplines into his practice to ensure individuals enjoy a long and happy life. He values building the long-term relationships that are necessary to co-create a roadmap for longevity and good health. I learned a lot from this conversation and I hope you will as well. What we discussed: Dr. Paziotopoulos's journey into anti-aging (1:18) Medical maintenance engineering and points of failure (3:43) The future of anti-aging and longevity (7:46) Challenges in the current healthcare system (9:50) Sustainability and population growth (13:33) The future role of AI and genetic engineering (18:29) His personal motivation and approach to health (20:46) Patients' struggle with certain behavioral traits and anxiety (24:52) Epigenetic traits passed down through generations (25:54) Science and living "forever" (30:21) Regenerative medicine, aging, and facing death (39:34) Personal nutrition choices (43:44) The impact of diet on the microbiome and the importance of regular testing (1:03:24) Where to learn more: The Pazio Institute If you loved this episode and our podcast, please take some time to rate and review us on Apple Podcasts, or drop us a comment below!
Empaths & Starseeds: Healing Ancestral Memories of the Orion Wars
Ep. 157 On today's episode of Pursuit of Wellness, Dr. Tyna Moore, a naturopathic and chiropractic physician with expertise in regenerative medicine, joins us to provide clarity on GLP-1 medications. With a background in metabolic health and chronic pain management, Dr. Tyna explains how GLP-1s can benefit individuals with weight loss goals, PCOS, and insulin resistance. She shares valuable advice on individualizing doses, understanding how these medications interact with insulin and muscle mass, and how to approach conversations with doctors about your dosage. We also cover the risks associated with Ozempic, especially in those dealing with metabolic dysfunction, and discuss how these drugs impact areas like fertility and chronic pain. Leave Me a Message - click here! For Mari's Instagram click here! For Pursuit of Wellness Podcast's Instagram click here! For Mari's Newsletter click here! For Dr. Tyna's Instagram click here! For Dr. Tyna's Website click here! Sponsored By: The holidays are closer than ever, so make sure you order by December 16th to get their gift (or yours) underneath the tree in time! Visit Carawayhome.com/POW to take advantage of this limited-time offer for up to 20% off your next purchase. Again that's Carawayhome.com/POW to get new kitchenware before the holidays. Caraway. Non-Toxic cookware made modern. Visit BetterHelp.com/POW today to get 10% off your first month. That's betterhelp.com/POW. Head to Manukora.com/POW to get $25 off the Starter Kit, which comes with an MGO 850+ Manuka Honey jar, 5 honey travel sticks, a wooden spoon, and a guidebook! Visit clearstemskincare.com and use code POW at checkout for 20% off your first purchase. Again, that's code POW for 20% off your first purchase on clearstemskincare.com. The Fits Everybody collection is available in sizes XXS to 4X. You can shop now at SKIMS.com. After you place your order, be sure to let them know I sent you! Select "podcast" in the survey and be sure to select my show in the dropdown menu that follows. And if you're looking for the perfect gifts for the whole family - SKIMS just launched their biggest Holiday Shop ever - also available at SKIMS.com. Show Links: Ozempic Uncovered University Dr. Tyna's GLP1s Done Right Dr Tyna GLP1 Episodes Finding A Doctor Episode Keywords + Tags (YouTube) Health, Wellness, Fitness, Nutrition, Pursuit of Wellness, Dr. Tyna, Semaglutide, Microdosing, Weight Loss, GLP-1, Regenerative Medicine, Metabolic Health, Podcast Host, Peptide, PCOS, Obesity, Fertility, Social Media Influencers, Mucus, Mucinex, TikTok, Cystic Acne, Epigenetic, Infertility, Spironolactone, Androgen, Orthorexia, Peptide, Menstrual Cycle, Anti Inflammatory, Pharmaceuticals, Hormones, Insulin Signaling, Insulin Reception, Insulin Resistant, Metabolic Pathways, Waist Circumference, Skinny Fat, Muscle Mass, Toned, Lean, Arm Sculpting, Crohn's, Microbiome, Ozempic, Muscle Loss, Heroin Chic, Chain Smoking, Metabolic Dysfunction, Dosage, Individualized Dosing, Freedom, Chronic Pain Topics Discussed 00:00:00 - Introduction 00:03:54 - Dr. Tyna's journey 00:06:44 - Initial success stories 00:07:54 - Fertility 00:09:20 - GLP-1's and cystic acne 00:16:22 - PCOS diagnosis 00:21:09 - Low dose GLP-1 benefits 00:29:18 - Who metabolic health applies to 00:31:53 - Pick up the weights! 00:34:41 - GLP-1's and the microbiome 00:37:20 - Ozempic mistakes 00:41:49 - How Ozempic affects the body 00:45:24 - Individualized dosing 00:48:01 - How to talk to your doctor about low dosing 00:52:56 - Cycling do's and don'ts 00:54:05 - Clarity around the different drugs 01:00:01 - GLP-1's and addiction 01:02:46 - Dr. Tyna's Ozempic Done Right University 01:05:45 - Wellness to Dr. Tyna
Do you know your biological age? How does one learn their biological age and how is it different from your chronological age? The answer lies in our epigenetics, which is how you live your life! In this fascinating episode of Salad with a Side of Fries, Jenn welcomes Hannah Went, co-founder of TruDiagnostic, to explore the science behind biological age testing. Together, they dive into the cutting-edge world of epigenetics, methylation, and the role of lifestyle in optimizing health. From understanding how epigenetic markers can predict disease risks to uncovering how simple changes can slow aging, this episode is packed with insights that could transform how you think about your health and longevity. The Salad With a Side of Fries podcast is hosted by Jenn Trepeck, discussing wellness and weight loss for real life, clearing up the myths, misinformation, bad science & marketing surrounding our nutrition knowledge and the food industry. Let's dive into wellness and weight loss for real life, including drinking, eating out, and skipping the grocery store. IN THIS EPISODE: [1:57] What is your biological age?[6:04] Hannah describes epigenetics and what they target in the blood through various tests.[9:54] What is methylation?[12:53] How is epigenetic testing different from Elizabeth Holmes and Theranos?[15:38] What are the privacy implications of taking these tests, and what can the tests reveal?[22:49] Studies around epigenetic information.[25:42] Slowing the progression of biomarkers that create disease.[29:05] Lifestyle changes can positively impact stress and overall health[32:19] There is power in testing.[33:39] Choosing the most compatible testing company.KEY TAKEAWAYS: Genetics and epigenetics offer complementary insights into human biology. Genetics represents the fixed "hardware" inherited equally from each parent, while epigenetics is the dynamic "software" influenced by interactions with the environment and personal behaviors. Unlike static genetic markers, epigenetic markers are often changeable, though some—like imprint markers—may be inherited, presenting exciting opportunities for biomarker discovery.While the classification of aging as a disease may be debated, it's clear that biological age clocks are becoming powerful tools for detecting disease signals. For example, one clock has shown 92% accuracy in predicting mortality, compared to 72% for chronological age. These biomarkers are improving and will soon include methylation risk scores for specific diseases, helping to assess individual disease risks more precisely. Aging may serve as a general indicator, providing valuable insights into disease likelihood and guiding interventions for better health outcomes.Aging and health assessments, like biological age testing, can serve as a valuable wake-up call, especially for those with room for improvement in their health and lifestyle. While biohacking and excessive supplementation are popular, they often lack clarity and balance, making it difficult to pinpoint what's truly effective. Simplicity is vital—maintaining a balanced approach is more beneficial than overloading the body with too many interventions, which can disrupt homeostasis and lead to less favorable results.QUOTES: [6:19] “I like to break down the word. So epi is a Greek prefix that actually just means above or on top of. So we're quite literally just looking on top of your genetics.” Hannah Went[7:25] “You can change your epigenetics and control your health. You can no longer blame, you know, your predisposition for disease based on your second cousins.” Hannah Went [7:40] “We are in control of our health. Genetics are this predisposition, but not a determining, inherent absolute.” Jenn Trepeck[12:14] “Epigenetics is actually a better marker in some cases in terms of disease predictability, odds ratios, hazard ratio and that's the point of the biomarker. How close can we get to that disease prediction?” Hannah Went[14:03] “Epigenetic tests are not a replacement for traditional lab tests. Instead, they're just providing a unique layer of insight into how your environment and lifestyle may be affecting your particular genes.” Hannah Went[27:18] “We can look at these results and let it be a wake up call to say, I may have different data so, I might want to make some lifestyle changes.” Jenn Trepeck[33:09] “You see things on social media nowadays, like ‘food is medicine'. ‘You are what you eat'. ‘Your DNA is not your destiny'. That's epigenetics. They're quite literally describing epigenetics without saying the word.” Hannah Went[35:06] “People get confused between what's truly genetic and what is inherited lifestyle. Something might run in your family, that doesn't necessarily mean it's genetic because the other thing that runs in families is lifestyle choices and habits.” Jenn TrepeckRESOURCES:Become A Member of Salad with a Side of FriesJenn's Free Menu PlanA Salad With a Side of FriesA Salad With A Side Of Fries MerchA Salad With a Side of Fries InstagramNutrition Nuggets for Epigenetics EpisodeGUEST RESOURCES: Everything Epigenetics - PodcastTrudiagnostic - WebsiteEverything Epigenetics - InstagramEverything Epi - TwitterGUEST BIOGRAPHY: Hannah Went has a lifelong passion for longevity and breakthrough, disruptive technologies that drive radical improvement to the human condition. She attended the University of Kentucky and graduated with a degree in Biology. She had multiple research internships studying cell signaling and cell biology then. After graduation, she worked for the International Peptide Society as their Director of Research and Content. Through work in the integrative medicine industry, Hannah saw an opportunity for methylation-based age diagnostics and started TruDiagnostic in 2020. TruDiagnostic focuses on methylation array-based diagnostics for life extension and preventive healthcare, serving functional medicine providers. TruDiagnostic is committed to research, with over 30 approved clinical trials investigating epigenetic methylation changes in longevity and health interventions. Since TruDiagnostic's inception, they have created one of the world's largest private epigenetic health databases, with over 75,000 patients tested. Hannah has since created Everything Epigenetics, sharing insights on how DNA regulation impacts health.
In this enlightening episode of Mindset Mastery Moments, Dr. Alisa Whyte welcomes world-renowned systemic coach and trainer Judy Wilkins-Smith. Together, they dive into the transformative concepts of "Success DNA" and "Relationship DNA," focusing on how epigenetic and ancestral patterns impact both our personal and professional lives. Judy, founder of System Dynamics for Individuals & Organizations, shares insights from her extensive experience with Fortune 500 clients, including NASA, Microsoft, JP Morgan, and others. Their discussion delves into Judy's groundbreaking approach to systemic work, using constellations to uncover and transcend inherited blocks that can hinder success.As they explore emotional DNA, Dr. Alisa and Judy discuss how our thoughts, feelings, and actions are shaped by ancestral patterns and often limit our potential. Judy explains the practice of constellation therapy as a way to make hidden beliefs visible and actionable, allowing individuals to rewire their "Success DNA" for meaningful growth. Dr. Alisa and Judy's conversation also covers the idea of embracing cultural heritage with confidence, breaking free from societal limitations, and the power of understanding one's own unique success blueprint.Connect and Contact Judy Wilkins-Smith:Website: https://judywilkins-smith.com/Instagram: @judywilkinssmithFacebook: Judy Wilkins-SmithLinkedIn: Judy Wilkins-SmithYouTube: Judy Wilkins-Smith ChannelJudy's Books:The Hidden Power in Your DNA: How to Use Genealogy to Explore Ancestral Patterns & Transform Your LifeDecoding Your Emotional Blueprint: A Powerful Guide to Transformation Through Disentangling Multigenerational Patterns (Sounds True)Connect and Contact Dr. Alisa Whyte on Mindset Mastery Moments and Mindset Mastery 360:Mindset Mastery Moments: WebsiteMindset Mastery 360: WebsiteBecome a supporter of this podcast: https://www.spreaker.com/podcast/mindset-mastery-moments--4488172/support.
This episode is packed with practical insights and inspiring moments, as Judy and Dr. Alisa discuss strategies for confronting fear, reshaping self-talk, and overcoming limiting beliefs. Judy explains how recognizing generational patterns can empower individuals to shift perspectives and create new paths to success. They also touch on Judy's “3.0 version” approach, strategies for visionary leadership, and coaching techniques to build resilience and foster transformation within organizations. Whether you're seeking personal growth, leadership skills, or a deeper understanding of how ancestral patterns influence your journey, this episode offers a profound guide to unlocking potential.Connect and Contact Judy Wilkins-Smith:Website: https://judywilkins-smith.com/Instagram: @judywilkinssmithFacebook: Judy Wilkins-SmithLinkedIn: Judy Wilkins-SmithYouTube: Judy Wilkins-Smith ChannelJudy's Books:The Hidden Power in Your DNA: How to Use Genealogy to Explore Ancestral Patterns & Transform Your LifeDecoding Your Emotional Blueprint: A Powerful Guide to Transformation Through Disentangling Multigenerational Patterns (Sounds True)Connect and Contact Dr. Alisa Whyte on Mindset Mastery Moments and Mindset Mastery 360:Mindset Mastery Moments: WebsiteMindset Mastery 360: WebsiteBecome a supporter of this podcast: https://www.spreaker.com/podcast/mindset-mastery-moments--4488172/support.
Welcome back to another episode of The Realfoodology Podcast! Today we're exploring the world of epigenetic coaching, genetic testing, and the exciting realm of peptides. I had the pleasure of sitting down with Lindsay from Designer Genes Co., where we discuss what it means to be an epigenetic coach and the transformative insights that genetic testing can offer. We also cover peptides in detail, including GLP-1 and their potential benefits for various health issues. If you're curious about how peptides could impact your health journey, this episode is packed with valuable information you won't want to miss! Timestamps: 06:36 - Epigenetic coaching 11:10 - COMT & your body's stress chemistry 15:54 - Body By Design DNA Testing 18:40 - BDNF 23:26 - Peptides overview 32:37 - Understanding the rise in peptide use 35:13 - Impacts of peptides 41:58 - Unpacking side effects and risks of GLP1s 48:58 - GLP1 dosing 51:58 - Triceptides 55:01 - Peptide shortages & regulation 57:03 - Peptides impact on Big Food 01:00:24 - KPB & BPC157 01:04:00 - Lindsey's favorite peptides 01:07:05 - Personal fitness journeys 01:09:36 - Cognitive function peptides 01:11:39 - Getting peptides 01:14:58 - Lindsey's health nonnegotiables Use Code REALFOODOLOGY for 10% off any of the following: Body By Design® DNA testing PepSquad Peptide Therapy Course KNOCKOUT Bundle (includes testing and peptides course) Sponsored By: Organifi Go to www.organifi.com/realfoodology and use code REALFOODOLOGY for 20% Off Cured Nutrition Go to www.curednutrition.com/realfoodology and use code REALFOODOLOGY for 20% off Paleovalley Save at 15% at paleovalley.com/realfoodology and use code REALFOODOLOGY Needed Use code REALFOODOLOGY at thisisneeded.com for 20% off Timeline Go to timelinenutrition.com/REALFOODOLOGY and use code REALFOODOLOGY for 10% off LMNT Get your free Sample Pack with any LMNT drink mix purchase at drinklmnt.com/realfoodology Check Out Lindsey: Instagram Website Check Out Courtney: LEAVE US A VOICE MESSAGE Check Out My new FREE Grocery Guide! @realfoodology @realfoodologypodcast www.realfoodology.com My Immune Supplement by 2x4 Air Dr Air Purifier AquaTru Water Filter EWG Tap Water Database Produced By: Drake Peterson
Episode Highlights With Hannah WentWhat biological age is and how we measure itUnderstanding cellular-based aging How we measure biological ageSprint speed and grip strength can be really loose indicators of biological ageUnderstanding epigenetic biomarker proxies and how to pull levers to improve your biological ageHow biological age is closely tied to all-cause mortality The biggest factors that affect biological age negatively or positively Not surprisingly, smoking and alcohol consumption are negative factors for biological ageDiet, physical activity, sleep, and stress make a big impact on biological ageHow caloric restriction comes into play for aging Pregnancy and menopause effects on aging Epigenetic transgenerational inheritance and how this affects our kidsHow sunlight affects biological age (and it might not be what you think)Spending time in green space and in nature has a positive effect on biological age and even IQBeing lonely is worse than smoking according to research from HarvardHow relationships and community improve biological ageResources We MentionTruDiagnostic (this link and code wellnessmama gives a discount)Hand Grip Strength Tester
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