Podcasts about ad4

Back in 2018 Nate Pack, who at the time was the "Undisputed King of The Airdyne" joined us for a conversation (Ep. 53) and this is the Intro we wrote for that episode:"The guys speak with Nate Pack about capacity and tolerance, about the engine and its gas tank, and get down in the weeds about numbers, which is no surprise as Nate holds a PhD in bio-engineering and is a self-described “smart guy”. He also has a high degree of mastery in extensive effort. During the conversation they divulge the secret workout everyone has been asking for, and the dietary pairings used to amplify its effect. Finally—since this is an exercise and fitness podcast—they analyze the numbers in order to coronate the undisputed king of the Airdyne, and discuss how to plot the linear progression curves of power and time to expose truth."Those numbers, achieved on the AD4 fan bike, which was the standard at the time, are:10 minutes = 412 calories20 minutes = 705 calories30 minutes = 1002 calories60 minutes = 1935 caloriesNate returns to the podcast to discuss the many years of growth and change that has occurred since. We started by discussing how easily we can trick ourselves into believing that more and harder effort can overcome other poor choices, generally those of the dietary kind but when that doesn't work it's time for wholesale change. After having realized that he had gained more weight than he could tolerate or overcome with power, and along the way lost much of his aerobic fitness, Nate made a change. "Sometimes the mirror reflects the image we want to see and not the truth."He started training base (intensity) only for 15-18 hours a week, some on bike but also a lot of walking. He dropped 40 pounds in 15 weeks, 3-4 pounds per week on average, and then consciously slowed it down, taking advantage of the positive feedback but also realizing he needed to turn conscious behavior into a habit, which is more or less automatic. He took another ten pounds off over eight weeks, and slowed the weight loss down even more, while not losing focus. By the time the Logan-to-Jackson (LOTOJA) bike race was held in early-September of 2023 he had lost sixty+ pounds and rebuilt his long endurance and long threshold fitness back.This was the first time on our podcast when the following phrase was spoken, "without going into the biochemistry of PGC-1 Alpha ...", which relates to mitochondrial biogenisis and "promotes the remodeling of muscle tissue to a fiber-type composition that is metabolically more oxidative and less glycolytic in nature, and it participates in the regulation of both carbohydrate and lipid metabolism."It's a fitness podcast and sometimes complex details are discussed so a detailed description of training intensity ensues, referencing mitochondrial biogenesis, work/rest ratios for intervals, effort that produces 2.5 mmol/l lactate but would produce 5 if sustained but it isn't, etc. Yes, down in the weeds a bit but we didn't stay there, shifting instead to the concept of sustainability and the necessity of a big volume of consistency; measuring progress in years, not merely weeks or months. Once the topic of physical training is exhausted we moved on to the psychological, to freeing himself of 'expectations of outcome' while never questioning the expectation of the effort he is willing to make ... and 'will I give all that I am willing to give? Not able but willing ...' What are we willing to give to achieve our objectives, and what do we hold in reserve to apply to other activities or relationships?We hit the offramp with an exchange about learning to be kind to oneself in the midst of the unfairness of the universe, "This is the lesson I was searching for: not more watts but more growth."It's a long and powerful conversation, and sometimes quite in a niche—not every moment will be for every listener—but the high points are universally applicable, and understandable to anyone who is paying attention to the long journey called life we are all taking.

The periods of Church History from Revelations:1. The Church at Ephesus/Loveless Church: 33 AD-100 AD2. The Church at Smyrna/Persecuted Church: 100 AD-312 AD3. The Church at Pergamos/Compromising Church: 312 AD-606 AD4. The Church at Thyatria/Corrupt Church: 606 AD-1520 AD5. The Church at Sardis/Dead Church: 1520 AD-Tribulation Period6. The Church at Philadelphia/Faithful: 1750 AD-Rapture of the Church7. The Church at Laodicean/Lukewarm Church: 1900 AD-Tribulation PeriodSupport the show (https://www.patreon.com/Keepingitbiblical?fan_landing=true)

On this episode of AD4, I'm joined by Roger Dooley, Forbes Brainy Marketing CMO Council, author, marketing pro and international keynote speaker who's used Neuromarketing principles to create content that's built huge website audiences. His personal record is 3 million unique visitors/month.  He's also the author of the 2 books Friction and Brainfluence, the host of the Brainfluence podcast which has featured Ryan Holiday, Guy Kawasaki, and nobel prize winner Al Roth. If that wasn't enough to convince you to hear him out he's also got decades of experience leading digital marketing organizations and currently runs his own Neuromarketing Consultancy. 

Should you get an MBA? Why did I decide to get one? What goes into the process for applying for one? I cover that in this episode of AD4

ADAM DEITCH B-DAY EXTRAVAGANZA! Episode 032 of *The Upful LIFE Podcast* is proud to welcome the one & only ADAM DEITCH to the show! It's an honor & privilege for this esteemed gentleman to slide through for a proper powwow. To celebrate his 4/26 b-day, we dig into a pair of fresh records: Lettuce's new LP Resonate (5/8), & his own forthcoming solo electronic EP The Age of Imperfection, AND check-in with his fam. Literally! His wonderful parents BOBBY & DENISE DEITCH hop on the phone to discuss all things Deitch. Bobby Deitch Band  new album dropping 5/15, so we get the scoop on that, plus loving parental reflections on Adam & his boys. Ep.032 finishes strong with the great RYAN ZOIDIS (sax - Lettuce, AD4, BrkSci Live Band). Zoid has collab'd with Adam Deitch for nearly a quarter century, he's a world-class musician & vibrant conversationalist. This episode is a family affair. HAPPY BIRTHDAY ADAM! #DeitchBeatsDontQuit - ISOLATION STATION v.4 ADAM DEITCH intro - 6:00 BOBBY & DENISE DEITCH intro - 41:00  RYAN ZOIDIS intro - 1:17:30  Adam Deitch needs no introduction. He's steadily among the more celebrated drummers in the game for over two decades, laying the foundation for modern funk music. He pushes the art skyward, prolific in hip-hop, electronic, and jazz. He's been the iconic engine powering Lettuce ever since the future-funk cosmonauts first took flight, back in the mid-1990's at Berklee College of Music in Boston. Their collective trajectory has been astonishing, as has his own journey in music. In addition to slaying with LETT, Deitch has collaborated with everybody from John Scofield to Pretty Lights to Redman & beyond. The GRAMMY-nominated artist is dropping new music left & right, even on quarantine. Deitch stays perpetually in motion, getting busy with his electro-soul duo Break Science, plus his own soul-jazz group Adam Deitch Quartet (featuring Ep.024 guest Wil Blades, and Lettuce's Ryan Zoidis (interviewed later in this program) & Eric Benny Bloom (Ep.017).      Transmitting from Denver, CO., Adam brings us into the Resonate recording and mixing sessions with super-producer Russ Elevado, as well as the band's writing and studio processes. Deitch discusses how LETT creative vibes coalesce, a general modus operandi for the current squadron, and highlights Elevado's dutiful influence. The drummer teases some possible dream collabs, with insightful backstories of how & why they might just happen. Adam gets into the "Funkin from Home" project, then pivots into his own production concepts, ideas, and compositions with regard to new electronic EP The Age of Imperfection. The dude waxes philosophic about sampling traditions, newer trends in the culture, then shows love to some young gunners pioneering the wave in that lo-fi hip-hop space. He tickles the fans with some clues about a new Nigel Hall solo album in the works. Maybe more Break Science acoustic? Towards the end, AD reveals his thoughts on the myriad of emotional elements ever-present in his rhythms & compositions. Universal language inherent in so much that he studies & loves. Always humble, forever a student, yet effortlessly the teacher. Fantastic, fulfilling, & deeply informative Adam Deitch interview! Here's to another ring around the sun, shogun!  Bobby & Denise Deitch were kind enough to make time for the podcast from their home/studio in Nyack, NY, just outside the city. Topics include: how the duo is sheltering-at-home, forthcoming album from Bobby Deitch Band titled Work With Whatcha Got, due May 15. Bobby Deitch breaks down his band, process, collaborators, song ideas, themes and intentions in rolling out this new record, which features Michealangelo Carubba & Shira Elias from Turkuaz (both guests on this show in the past), in addition to living legend George Porter Jr., Lettuce's Nigel Hall, among other special guests. Denise frequently chimes in with some funny tidbits on their shared creative energy and how the couple carefully builds a song from scratch. Naturally, I asked Adam's parents for some reflections on their son, his bands, their brotherhood, and his ever-prolific output. Get the latest on Bobby & Denise Deitch music HERE                 ENTER THE ZOID VOID: The final conversation is a profound exchange with my dear friend RYAN ZOIDIS, whom I reached super late on 4/20 night at his home in Portland, ME.. Zoidis is another LETT co-founder, & part of Adam Deitch Quartet, Break Science Live Band, Soulive's Shady Horns, critically-acclaimed Rustic Overtones, & Royal Hammer (Portland roots-reggae crew). Zoid gets personal how the relationship with his young daughter has evolved and transformed during quarantine. How the virtuoso saxman has improved as both musician & teacher. We revisit Russ Elevado's Voodoo touch, how the venerable producer magically elevated the LETT sessions with poignant palette cleansing of the highest order. Zoidis pulls the curtain back on a couple of favorite Resonate joints, floats dreamy ideas for a psychedelic improv/instrumental LETT release, and how the band's recent jaunt through Europe brought the squad even closer, vibrations onstage and off. Zoid kicks knowledge & drops science on natural wines, & introduces his new 'natty-wine' distribution company Benny & Zoid Selections, with bandmate Eric Benny Bloom. Meanwhile, what's up with a rumored wild collab project with Tycoon & Jesus Coomes!? We wrap up this sesh with a string of enlightening topics, beginning with Ryan's beautiful recollections & ruminations on his relationship with the Deitch family. Zoid offers parting thoughts on Still Bill, and seminal dancehall DJ Toyan's timeless classic LP How the West Was Won. Large Up Ryan Zoidis! One of my favorite dudes on earth, hands down.  (Zoidis painting in thumbnail by Aaron Schwartz)  -Vibe Junkie JAMZ of the Week- Lettuce - 'HOUSE OF LETT' off their forthcoming LP Resonate, due May 8. Adam Deitch - 'SPACE DUST' off next EP The Age of Imperfection (date TBD) hidden track- "Judy"-WRD (Robert Walter, Eddie Roberts, Adam Deitch - Color Red Music)   EMAIL the SHOW! B.Getz@UpfulLIFE.com PLEASE LEAVE A REVIEW on iTunes! You Can Listen on Spotify!  Theme Song: Mazel Tov by CALVIN VALENTINE

Episode 024 of *The Upful LIFE Podcast* welcomes Hammond B3 organ maestro WIL BLADES to the show for a lengthy conversation about his career, Bay Area music culture, saddling up to jazz and funk legends, the Adam Deitch Quartet, Amendola vs. Blades, and beyond. From bright eyed young cat in Chicago, to one of the rising stars in jazz and groove music, he's among the more impressive organ players in the culture today. Just a few days before he was moving to SoCal, Wil invited me over to his home in Berkeley, CA to have a spirited discussion, and was game to go deep about his own journey, the nuances of Hammond B3 organ, his passion for rare groove, the oral tradition of music, the history of the Boom Boom Room, and so much more. It was an honor to give Wil a chance to really let the people know who he is and how he got to be such a respected and celebrated musician, and to shed a lot of light on historical cats along the way. 7:00 - Wil Blades INTRO 12:45 - Amendola vs. Blades "Hi Lo"  15:00 - WIL'S INTERVIEW STARTS   1:33:30 "Art Bar" - Adam Deitch Quartet      We start the conversation in Wil's youth growing up near Chicago in Evanston, IN, learning both the drums and guitar as a youngster, taking ques from his older brothers. We also spend some time talking about how we discovered music as kids in the 90's, and how that is so markedly different from how Wil's teen children find their favorite artists today. From there, he takes us back to the late 90's, moving across the country to the Bay Area to join an Oakland jamband and attend college. Wil explains how SF and Oakland were very different back in those days, and how a particular college professor with a heavy resume and unique teaching style put him on to the importance of the oral tradition in music. At the time of the interview, Wil was preparing to move to Los Angeles after twenty years in the Bay. Wil gives us a colorful reflection on the music scene when he first arrived in the Bay Area, and for much of the convo he continues to tell the tale about how the music and culture would evolve over the next two decades. Wil was/remains also a huge part of the scene at renowned SF venue Boom Boom Room, a hotbed for blues when he arrived, but later evolving into the epicenter for all things NOLA and funky here in NorCal. Wil breaks down what it was like as John Lee Hooker's Boom Boom Room, and how talent buyer Alex/Xander Andreas's vision has helped the club to continue to flourish with the funk. Wil Blades has studied with some of true legends, and talks in great detail about his time with master organist Dr. Lonnie Smith, the late iconic funk/jazz drummer Idris Muhammed, an beloved late hollow-body guitarist Melvin Sparks. Wil has spent time with and performed alongside each of these giants, and it was riveting to hear how he organically and serendipitously came to connect with such luminaries, and what a thrill it was to hear of ho w each of them put him on game.  Wil makes sure to explore the essential particulars of organ/drums relationship. Two thirds of the way through the interview, we finally arrive at the Adam Deitch Quartet, Wil's fantastic project with the Lettuce/Break Science drummer wunderkind. We play a portion of the Blades-penned "Art Bar", then return to our dialogue. Wil retraces the steps on how that relationship came together, and gets into the magic that makes it all happen with Deitch, Eric Benny Bloom (trumpet) and Ryan Zoidis (sax). We discuss the making of their critically-acclaimed LP Egyptian Secrets, and reminisce on some classic AD4 gigs thru the years. Wil spends some time discussing his tremendous Amendola vs. Blades project with Bay Area groove merchant Scott Amendola, and their new LP Everybody Wins (Royal Potato Family), and their short West Coast tour. Wil Blades finishes out this phenomenal interview by talking about what's he excited about in moving down to LA after two decades as a prodigal son of the Bay.     Vibe Junkie JAM of the Week (2:04) "11th Hour" by DROPICAL, off his new EP Circling Out (Jumpsuit Records)     Email the show! B.Getz@upfulLIFE.com The Upful LIFE Podcast is available on iTunes! Also available on Spotify!  Theme Song: Mazel Tov by CALVIN VALENTINE  

Nevada Assembly candidates C. Kelly Hurst (AD-9) and Michele Fiore (AD-4) dish on their opponents, sunset taxes, and medical marijuana.

Human adenoviruses (Ads) have evolved elaborate mechanisms to counteract the host’s antiviral immune response. The early transcription unit 3 (E3) of the virus is not essential for virus replication in vitro, but is known to encode proteins with immunomodulatory functions. The Ad2 E3/10.4-14.5K proteins are both integral membrane proteins, which form a physical complex and function together to modulate cell surface expression of the EGFR and selective members of the TNF/NGF receptor superfamily, namely Fas/CD95 and TRAIL-R1, whereas TRAIL-R2 modulation additionally requires E3/6.7K. In a process referred to as receptor down-regulation, 10.4-14.5K relocates receptor targets from the cell surface to lysosomes for degradation. The aim of this study was to characterize functional determinants within the Ad2 10.4-14.5K proteins, that are required for down-regulation of plasma membrane receptors. In particular, I focussed on the characterization of potential transport motifs present in the cytoplasmic tail of both proteins: The Ad2 14.5K tail contains three YXXF sequence motifs (Y denotes tyrosine, X any amino acid and F a bulky, hydrophobic residue) while the Ad2 10.4K sequence displays two consensus elements of the second large class of transport signals, the dileucine motifs. Both types of motifs are recognized by cellular adaptor proteins which select cargo for directed transport in clathrin-coated vesicles. FACS analysis of stable E3-transfectants expressing 10.4-14.5K mutant proteins revealed that residues contained within these putative transport motifs were essential for down-regulation of Fas and the EGFR in vivo. Receptor expression was restored when either the dileucine pair (LL87,88) of 10.4K or 14.5K Y74 or Y122 were replaced by alanine. Whereas loss of function of the 14.5K mutant Y74 can be explained by its inability to interact with 10.4K, several lines of evidence suggest that the 10.4K dileucine pair and 14.5 Y122XXF motif function as transport signals: (i) Surface plasmon resonance spectroscopy showed that mutation of the two motifs prevents binding of 10.4K and 14.5K cytoplasmic tail peptides to purified adaptor protein complexes AP-1 and AP-2 in vitro. (ii) FACS analysis demonstrated that mutation of these motifs strongly affects FLAG-14.5K cell surface expression. (iii) In line with the FACS data, immunofluorescence microscopy revealed that mutant 14.5Y122A accumulates together with 10.4K at the cell surface, suggesting that the Y122FNL motif normally directs internalization of 10.4-14.5K. (iv) Substitution of the 10.4K dileucine pair increased the transport of 10.4-14.5K into lysosomes, resulting in enhanced degradation of both 10.4K and 14.5K without significantly disrupting complex formation. (v) The accumulation of mutant 10.4-14.5K at the cell surface upon coexpression of 10.4LL/AA and 14.5Y122A suggests that the dileucine motif acts downstream of Y122 and fulfills a sorting function subsequent to endocytosis. Transfer of the mutations into Ad2 and infection of primary fibroblasts revealed a similar defect in trafficking of 10.4LL/AA and 14.5 Y122A mutant proteins. Moreover, in infected cells substitution of the 10.4K dileucine pair and 14.5K Y122 impaired down-regulation of Fas, EGFR and both TRAIL-R1 and TRAIL-R2, implying a general role of these sorting signals for the mechanism of receptor down-regulation. Thus, two distinct transport signals present in the different subunits of the 10.4-14.5K complex seem to act in concert to establish efficient down-regulation of receptor targets. Alanine replacement mutagenesis of several other strictly conserved amino acids in 14.5K and FACS analysis of stable E3-transfectants revealed that those mutants which exhibited an altered FLAG-14.5K surface expression had defects in Fas and EGFR down-modulation. Surprisingly, Ad4 was unable to modulate Fas and EGFR expression, even though the Ad4 14.5K protein contained all the strictly conserved amino acids. As a first step to identify structural features that determine target specificity of 10.4-14.5K, I chose to replace the 10.4-14.5K ORFs in Ad2 by their Ad4 homologues. Although the Ad4 10.4-14.5K proteins could be detected in Ad4-infected cells, their expression level was drastically reduced when encoded by the Ad2 E3 region. This indicated that expression of Ad4 10.4-14.5K is differently regulated as compared to Ad2, possibly due to altered splicing. Further exploration of this system will require a detailed analysis of splicing within the Ad4 E3 region