Podcasts about Modulation

Links For The Occult Rejectshttps://linktr.ee/theoccultrejectsOccult Research Institutehttps://www.occultresearchinstitute.org/Substackhttps://substack.com/@theoccultrejects?r=7auau0&utm_campaign=profile&utm_medium=profile-pageCash Apphttps://cash.app/$theoccultrejectsVenmo@TheOccultRejectsBuy Me A Coffeebuymeacoffee.com/TheOccultRejectsPatreonhttps://www.patreon.com/TheOccultRejectsPart 1: The Road of RhythmPart 1 focuses on the drum as an ancient technology of altered consciousness. The argument is not that every beat causes trance, or that neuroscience has proven spirits. The stronger argument is that rhythm enters the human organism through hearing, motor prediction, breath, movement, attention, emotion, expectation, culture, and social synchrony. The drum becomes powerful when sound, body, group, ritual frame, and meaning converge. These sources support the archaeology, neuroscience, EEG research, shamanic studies, possession studies, Indigenous and culturally specific drum traditions, ritual theory, placebo and meaning-response research, ceremonial magic, and modern witchcraft material used in the episode.Core Academic and Scientific SourcesHuels, Emma R., Hyoungkyu Kim, UnCheol Lee, Tirsa Bel-Bahar, Ana V. Colmenero, Alexandra Nelson, Stefanie Blain-Moraes, George A. Mashour, and Richard E. Harris. “Neural Correlates of the Shamanic State of Consciousness.” Frontiers in Human Neuroscience 15 (2021): 610466. Use for the strongest modern EEG anchor. This study used high-density EEG with shamanic practitioners and controls during rest, shamanic drumming, and classical music listening. It assessed altered-state reports alongside brain measures such as power, connectivity, signal diversity, and criticality. Use carefully: the study does not prove spirits or show that drumming mechanically causes trance in everyone. It supports the more careful claim that trained practitioners entering shamanic states with drumming show measurable brain-state differences.Gordon, Yoel, Golan Karvat, Noa Dagan, and Ayelet N. Landau. “Neural Tracking at Theta Predicts Drumming-Induced Altered States of Consciousness.” Scientific Reports 16, no. 1 (2026): Article 10204. Use for the strongest updated drumming/theta/neural-tracking source. This study tested drumming at theta, delta, and alpha-rate rhythms while recording EEG, and found that stronger rhythmic neural tracking at theta was linked to stronger altered-experience reports. Use carefully: this does not mean theta equals the spirit world or that one frequency opens a portal. The serious point is that altered experience may depend partly on how strongly the nervous system tracks rhythmic stimulation.Aparicio-Terrés, R., et al. “The Neurobiology of Altered States of Consciousness Induced by Drumming and Other Rhythmic Sound Patterns.” Annals of the New York Academy of Sciences, 2025. Use for the newer review literature showing that rhythmic sound is now a serious altered-consciousness research topic. This supports the opening claim that modern academia is examining drumming, rhythmic sound, absorption, relaxation, cognition, and neural activity without reducing the subject to one simple “trance frequency.” The review is especially useful for framing the field as promising but still complex.Neher, Andrew. “Auditory Driving Observed with Scalp Electrodes in Normal Subjects.” Electroencephalography and Clinical Neurophysiology 13 (1961): 449–451. Use for the historical bridge between repetitive sound, EEG, auditory driving, and early scientific interest in rhythmic stimulation.Neher, Andrew. “A Physiological Explanation of Unusual Behavior in Ceremonies Involving Drums.” Human Biology 34, no. 2 (1962): 151–160. Use carefully. This is useful as an early attempt to connect ceremonial drumming and physiology, but it should be balanced with Rouget because the “drum simply causes trance” argument is too mechanical.Maurer, R., V. K. Kumar, L. Woodside, and R. J. Pekala. “Phenomenological Experience in Response to Monotonous Drumming and Hypnotizability.” American Journal of Clinical Hypnosis 40, no. 2 (1997): 130–145. Use for monotonous drumming, subjective altered experience, imagery, absorption, and hypnotizability.Maxfield, Melinda C. “Effects of Rhythmic Drumming on EEG and Subjective Experience.” PhD diss., Institute of Transpersonal Psychology, 1990. Use as older supporting context on drumming, EEG, imagery, body-image changes, and subjective altered experience. Do not make this the main scientific proof; use it as background.Nozaradan, Sylvie, Isabelle Peretz, and André Mouraux. “Tagging the Neuronal Entrainment to Beat and Meter.” The Journal of Neuroscience 31, no. 28 (2011): 10234–10240. Use for EEG evidence that the brain can track beat and meter. This supports the claim that the brain does not merely hear rhythm as background sound; it can represent rhythmic structure in measurable ways.Nozaradan, Sylvie. “Exploring How Musical Rhythm Entrains Brain Activity with Electroencephalogram Frequency-Tagging.” Philosophical Transactions of the Royal Society B 369, no. 1658 (2014). Use as broader rhythm/EEG entrainment support. This helps explain frequency-tagging, beat tracking, meter, neural entrainment, and the measurable relationship between rhythmic structure and brain activity.Thaut, Michael H., Gerald C. McIntosh, and Volker Hoemberg. “Neurobiological Foundations of Neurologic Music Therapy: Rhythmic Entrainment and the Motor System.” Frontiers in Psychology 5 (2015). Use for rhythm as motor-system timing information. This supports the claim that a beat can become bodily instruction, not just sound for the ear. Especially useful when discussing rhythmic auditory stimulation, motor planning, gait, entrainment, and the auditory-motor bridge.Ross, Jessica M., John R. Iversen, and Ramesh Balasubramaniam. “Time Perception for Musical Rhythms: Sensorimotor Perspectives on Entrainment, Simulation, and Prediction.” 2022. Use for rhythm, timing, prediction, sensorimotor entrainment, and the way musical rhythm interacts with time perception.Hove, Michael J., and Jane L. Risen. “It's All in the Timing: Interpersonal Synchrony Increases Affiliation.” Social Cognition 27, no. 6 (2009): 949–960. Use for synchrony and social bonding. This helps support the group-body argument: moving or acting in time with others can increase affiliation.Wiltermuth, Scott S., and Chip Heath. “Synchrony and Cooperation.” Psychological Science 20, no. 1 (2009): 1–5. Use for the claim that synchronized movement can increase cooperation and attachment among participants.Tarr, Bronwyn, Jacques Launay, and Robin I. M. Dunbar. “Music and Social Bonding: ‘Self-Other' Merging and Neurohormonal Mechanisms.” Frontiers in Psychology 5 (2014): 1096. Use for music, synchrony, bonding, endorphin/social mechanisms, and why group rhythm can feel like more than private listening.Fancourt, Daisy, Rosie Perkins, Sara Ascenso, Louise Atkins, Fatima Kilfeather, and Aaron Williamon. “Effects of Group Drumming Interventions on Anxiety, Depression, Social Resilience and Inflammatory Immune Response among Mental Health Service Users.” PLOS ONE 11, no. 3 (2016): e0151136. Use for modern group-drumming research showing psychological and physiological effects, including anxiety, depression, social resilience, wellbeing, and inflammatory immune response. Use carefully: this does not make group drumming a cure-all. It supports the more grounded claim that embodied rhythm and group participation can affect mood, social connection, and body chemistry.Bittman, Barry B., et al. “Composite Effects of Group Drumming Music Therapy on Modulation of Neuroendocrine-Immune Parameters in Normal Subjects.” Alternative Therapies in Health and Medicine 7, no. 1 (2001): 38–47. Use as older supporting material on group drumming and neuroendocrine-immune measures. Keep secondary. Fancourt is cleaner for the main script body.Archaeology and Deep History of DrumsLawergren, Bo. “Neolithic Drums in China.” In Music Archaeology in China. 2006. Use for clay drums in Neolithic China and the deep-history claim that drums are not just poetic symbols of antiquity. They appear in the archaeological record as instruments tied to early sound-making, ceremony, and social order.Both, Arnd Adje. “Music Archaeology: Some Methodological and Theoretical Considerations.” Use as general support for why ancient instruments should be treated as ritual and social evidence, not merely decorative objects.Anthropology, Ethnomusicology, Ritual, and TranceRouget, Gilbert. Music and Trance: A Theory of the Relations Between Music and Possession. Translated by Brunhilde Biebuyck. Chicago: University of Chicago Press, 1985. Essential source. Use for the caution that music does not mechanically or universally cause trance. Rouget helps keep the argument academically serious by emphasizing culture, ritual frame, meaning, and expectation.Becker, Judith. Deep Listeners: MAlso want to remind people about the website, if you're into reading we have tons of information by multiple contributors, and we got t-shirts up on the site if you're interested. Fun fact, the art is all based on the eyeball. A

In dieser Folge von Ergotherapie unverpackt sprechen wir über Endometriose und Adenomyose – zwei chronische gynäkologische Erkrankungen, die oft viel zu spät erkannt werden und das Leben Betroffener massiv beeinflussen können.Es geht nicht nur um starke Regelschmerzen. Es geht um Erschöpfung, Rückzug, Scham, Leistungsdruck, unerfüllten Kinderwunsch, Schmerzen beim Sex, Probleme im Alltag und um das Gefühl, dem eigenen Körper nicht mehr richtig vertrauen zu können.Wir schauen darauf, was Endometriose und Adenomyose unterscheidet, welche Symptome typisch sein können und warum Schmerz nicht immer direkt mit dem sichtbaren Befund zusammenpasst. Manche Menschen haben starke Befunde und wenig Schmerzen, andere scheinbar kleinere Befunde und enorme Einschränkungen. Genau hier wird das Thema auch für die Ergotherapie relevant.Ein Schwerpunkt dieser Folge ist die Frage:Was kann Ergotherapie bei chronischem Schmerz, Fatigue, Überforderung und eingeschränkter Teilhabe konkret beitragen?Wir sprechen über Schmerzgedächtnis, zentrale Sensibilisierung, Amygdala, Arousal-Fenster, Hyperarousal und Hypoarousal – aber so, dass es verständlich bleibt. Außerdem geht es um konkrete therapeutische Werkzeuge wie Pacing, Energietagebuch, Fatigue-Management, sensorische Modulation, Körperwahrnehmung, Betätigungsanalyse, Alltagserleichterung und die Frage, wie Betroffene wieder mehr Selbstwirksamkeit erleben können.Diese Folge richtet sich an Betroffene, Angehörige und Fachpersonen, die besser verstehen möchten, warum chronischer Schmerz nie „nur körperlich“ ist, sondern immer auch Alltag, Beziehung, Nervensystem, Psyche und Teilhabe berührt.Worum es in dieser Folge gehtEndometriose und Adenomyose verständlich erklärttypische Symptome und mögliche Unterschiedewarum Diagnosen oft spät gestellt werdenwarum chronischer Schmerz das Nervensystem verändertwas Schmerzgedächtnis und zentrale Sensibilisierung bedeutenwie sich Fatigue, Scham und Rückzug auf Alltag und Teilhabe auswirkenwelche Rolle Ergotherapie spielen kannkonkrete Ideen für therapeutisches Arbeiten mit Betroffenenwarum Validierung, Sicherheit und Selbstwirksamkeit zentrale Wirkfaktoren sindWichtiger HinweisDiese Folge ersetzt keine medizinische Diagnostik oder Behandlung. Bei starken, wiederkehrenden oder zunehmenden Beschwerden sollte eine fachärztliche Abklärung erfolgen – idealerweise bei Ärzt oder Zentren mit Erfahrung im Bereich Endometriose und Adenomyose.#Ergotherapie #ErgotherapieUnverpackt #Endometriose #Adenomyose #ChronischerSchmerz #Schmerzgedächtnis #Fatigue #Teilhabe #Frauengesundheit #Gynäkologie #Schmerztherapie #ArousalFenster #SensorischeModulation #Pacing #Selbstwirksamkeit #GesundheitspodcastVielen Dank fürs Hören und Teilen, eure Line und eure WolfgangMixed & Mastered by SOUNDWERK

Warum wirken manche KI-Stimmen heute angenehmer als echte Menschen? Du hörst ein Video, einen Podcast oder einen gesprochenen Text und denkst: „Diese Stimme klingt ruhig, klar und präsent.“ Erst später bemerkst Du: Das war gar kein Mensch. KI-Stimmen haben in den letzten Jahren enorme Fortschritte gemacht – technisch und vor allem in ihrer Wirkung auf uns als Zuhörer. Doch genau darin steckt auch eine spannende Erkenntnis über menschliche Kommunikation. Arno Fischbacher und Andreas Giermaier sprechen darüber, warum viele Menschen im Alltag stimmlich unter ihren Möglichkeiten bleiben, weshalb moderne KI-Stimmen oft souveräner wirken als menschliche Gewohnheitssprache und woran wir trotz perfekter Sprachsynthese noch echte Persönlichkeit erkennen. In dieser Episode erfährst Du: warum moderne KI-Stimmen heute oft natürlicher wirken als erwartet woran Du künstlich erzeugte Stimmen überhaupt noch erkennst welche Rolle Sprachmelodie, Präsenz und Modulation dabei spielen warum viele Menschen im Alltag stimmlich „unter Potenzial“ sprechen wie Gewohnheit Deine Wirkung beeinflusst weshalb Vertrauen nicht nur über Worte entsteht was Du von KI-Stimmen für Deine eigene Kommunikation lernen kannst Warum ist das für Deinen Berufsalltag relevant? Ob in Meetings, Kundengesprächen, Präsentationen, Videos oder Podcasts: Menschen reagieren innerhalb von Sekunden auf den Klang Deiner Stimme. Noch bevor Inhalte bewusst verstanden werden, entscheidet der Tonfall über Aufmerksamkeit, Vertrauen und Präsenz. Gerade in digitalen Formaten wird hörbar, ob jemand innerlich klar, zugewandt und präsent spricht – oder nur Informationen transportiert. Diese Episode schärft Deinen Blick – und vor allem Dein Gehör – für genau diese feinen Unterschiede. Welche Frage kannst Du nach dieser Episode mitnehmen? Wenn künstliche Stimmen heute oft angenehmer klingen als menschliche Alltagssprache – was würde sich verändern, wenn Du Deine eigene Stimme bewusster einsetzen würdest? Vielleicht hörst Du nach dieser Episode nicht nur KI-Stimmen anders. Sondern auch Dich selbst. Dein persönlicher SELBSTCHECK FÜHRUNG hier kostenlos **********Dein Voicecoach Arno Fischbacher begleitet Dich auf Deinem persönlichen Weg von Stimm-Besitzer zum Stimm-Benutzer!Die beiden Hosts dieses Podcasts: Arno Fischbacher und Andreas K. Giermaier (Lernen der Zukunft)✅ Hast Du Fragen? Schreib an podcast@arno-fischbacher.com✅ Du willst mit Arno persönlich sprechen? Gern: https://arno-fischbacher.com/espresso

Marco Quarta is co-founder and Chief Scientific Officer of Rubedo Life Sciences, a precision-therapeutics company developing medicines that target the pathological cell states that drive age-associated disease. Marco's first appearance on the show was three years ago, in February 2023 (Episode 35), when Rubedo was a much earlier-stage company committed to the then-contrarian premise that "the senescent cell" is not a single entity but a heterogeneous family of cell states that needs to be deconvoluted at the single-cell level. In March 2026, Rubedo reported preliminary Phase 1b/2a clinical data for its lead candidate, RLS-1496, a first-in-class topical GPX4 modulator. Marco returns to the show to discuss what survived contact with human biology.In this episode, Chris and Marco unpack the readout from Rubedo's basket trial across four skin indications — psoriasis, atopic dermatitis, actinic keratosis, and photoaged skin — and the biology that underlies it. RLS-1496 came clean on safety in all four indications, with significant efficacy signals despite small patient numbers and short (20–30 day) treatment courses. More provocatively, the clinical and translational data have pushed Marco to redefine what kind of drug this actually is. Rather than a next-generation senolytic, GPX4 modulation appears to act as a state-gating intervention: it triggers ferroptosis in deeply senescent cells that have already crossed a redox threshold, while inducing a hormetic "redox reset" in stressed-but-recoverable cells that restores them to a healthier state. Marco proposes a new category to capture this dual action — adaptive senotherapeutics, or senoadaptive drugs — distinct from senolytics and senomorphics.The conversation traces the arc from Rubedo's founding thesis to a clinically validated platform (ALEMBIC, the AI-enabled single-cell multiomics engine that surfaced GPX4 as a target), through the strategic logic of leading with skin, into the broader question every longevity-biotech founder eventually has to answer: when does a disease-by-disease franchise become a credible preventive geroscience platform? Marco lays out the GLP-1 analogy explicitly — an anchor indication and a label-expansion roadmap that could carry GPX4 modulation from dermatology into respiratory, neurodegenerative, and metabolic disease, and ultimately into the use case where biomarkers of cellular senescence flag patients for therapy decades before disease becomes clinically apparent.The Finer Details:How Marco's 2023 contrarian view — that "senescent cells" hide a tissue- and state-specific reality — has been reinforced by the clinic, and how Rubedo's framing has shifted from "targeting senescent cells" to "targeting pathological cell states"The biology of GPX4 as a lipid-peroxidation gatekeeper, why senescent cells have intrinsic vulnerabilities (p16, p21, CDK4/6 inhibition) that make them ferroptosis-sensitive, and how Rubedo's approach differs from oncology-focused GPX4 programs at Takeda and othersThe "senoadaptive" mechanism — RLS-1496 eliminates GPX4-dependent senescent cells via ferroptosis while triggering NRF2/Keap1-driven redox reset, autophagy, and epigenetic remodeling in recoverable cells, restoring tissue trajectory from degenerative to regenerativeWhy Rubedo led with skin: clean regulatory path, accessible tissue, the ability to read out aging biology anddisease in the same trial, and a label-expansion runway into systemic indicationsPhase 1b (Europe) and Phase 2a (US) basket-trial results across psoriasis, atopic dermatitis, photoaged skin, and actinic keratosis: clean safety in 4/4 indications and significant efficacy signals — itch reduction in atopic dermatitis, decreased lesional thickness in psoriasis, target-engagement-correlated clinical improvement in photoaged skinThe richness of the translational dataset: biopsies, tape-stripping, spatial transcriptomics, proteomics, multiplex histomics, plasma biomarkers — all feeding back into ALEMBIC to refine the platformWhy actinic keratosis is the most strategically important indication — an age-related, chronic-inflammatory, precancerous condition where Rubedo can simultaneously test disease modification and biological-age reversalThe Rubedo–Beiersdorf partnership and the cosmetic vertical as a parallel commercial axisPipeline beyond skin: targeting aberrant basaloid stem cells in IPF and other pulmonary indications using different modalities (prodrugs, PROTACs, ADCs) to achieve cell-state selectivityThe longer-arc vision: senescence biomarkers as a "prediabetes-style" early signal, with senoadaptive drugs deployed decades before disease — and what a GLP-1-scale franchise might look like for GPX4 modulationQuotes:"There is not such a thing as a senescent cell — like there is not a cancer cell. And that was the initial idea. I'm glad that over time the field evolved. Now this is an accepted concept in the senotherapeutic space.""We are really talking about a dual function of RLS-1496 that can modulate the cell state depending on the adaptive response. That's why we call this — de facto — a new class of senotherapeutics. We call them adaptive senotherapeutics, or senoadaptive drugs — not a senolytic or a senomorphic, but working by modulating the cell state.""The best animal model for human therapies is human. As much as you can do preclinical work in animal models, it's always an approximation. We were able to test this directly in patients for safety, and in 4 out of 4 indications, we didn't have any safety signal.""Imagine you're taking care of a growing tree, and this tree has some dead leaves and some are a little bit stressed. If you shake the tree, the dead leaves will fall; the healthy leaves will not, because they're healthy and they resist the shake. But that shake actually gives the stressed leaves space and breathing room, and helps them to regain vitality. That's a little bit what GPX4 modulation does.""Senotherapeutics is a large, growing field — an untapped therapeutic opportunity. There is no such thing as a pan-senolytic or a pan-senotherapeutic, like there is no pan-oncotherapeutic. You need to understand the context. But these will all be part of the arsenal for true longevity medicine.""I don't see this as prevention of disease. The way I see therapies like ours, and the way the field of longevity is developing, is treating diseases decades before they develop. That's not a new concept — that's what we're doing in diabetes. You can be diagnosed with prediabetes today and reverse those biomarkers with lifestyle changes or metformin, and maybe never develop diabetes. That's exactly what we're doing here.""First of all, celebrating the first approved drugs from Rubedo — I don't think we're too far from that. But that's also a beginning, because you learn from the big momentum the GLP-1 agonists created: how a drug can start in one indication, create a new field, and prove that you can go beyond that. I hope in a few years we come back and talk about the next GLP-1 — this could be GPX4 modulators, or the senoadaptive drugs that are first in our pipeline."Links:Rubedo Life Sciences: https://www.rubedolife.comMarco Quarta's previous appearance on Translating Aging: Ep 35 — Targeting Pathologic Cells to Preserve Biological Youth

My Set from Modulation, Saturday 2nd May 2026. Oldskool Uplifting & House - All tracks from 1992. SoundCloud: https://soundcloud.com/djmikespeed/modulation_boomboxalldayer_theloft_0200526 MixCloud: https://www.mixcloud.com/djmikespeed/mike-speed-modulation-boombox-alldayer-the-loft-cleckheaton-020526-2000-2100/ Modulation - Boombox Alldayer The Loft, Cleckheaton Saturday 2nd May 2026 Pete Mosoon Mighty Ming Greenbins Dannie Kavanagh (Live Piano Set) Mike Speed Ste Huxley Vinyldoctor Danny Zacc Merek B2B Richard Gell Warren G Daz Page Jamtronik J-Funk 3pm until 2am. Bookings: 07787 164 054 Contact me on djmikespeed@hotmail.com All genres of Oldskool covered, From House, to Breakbeat, to Trance and Harder. Also on all formats Vinyl to Digital. Done all for the love ❤️ of the Oldskool! Links | dj mike speed Downloads & Social Links www.djmikespeed.co.uk Email | djmikespeed@hotmail.com SoundCloud | @djmikespeed MixCloud | www.mixcloud.com/djmikespeed/ HearThis | hearthis.at/djmikespeed/ Facebook: www.facebook.com/djmikespeedvinyloldskool Or search & add 'Mike Speed'

OsteoBites welcomes Caroline Maloney, MD, PhD, from the Medical College of Wisconsin, who will discuss her research on surgery-accelerated metastasis and developing perioperative therapies.Pulmonary metastasis remains the major cause of death in osteosarcoma. The timing of metastatic relapse defines clinically meaningful subgroups in osteosarcoma with patients who relapse within 6–12 months of surgical removal of their primary tumor having markedly worse survival (10-20%) than those who relapse after completion of therapy (40-50%). While surgical removal of the primary tumor is a fundamental component of the clinical care of solid tumors, surgery induces transient but profound changes in immune and inflammatory responses that can paradoxically accelerate the growth of metastatic disease. Dr. Maloney has demonstrated that surgical removal of the primary tumor accelerates the growth of pre-existing pulmonary metastatic disease and promotes expansion of M2‐like macrophages in the lung microenvironment. Strikingly, short term perioperative treatment with a RIPK2 inhibitor blocks this effect and reprograms macrophages toward an M1-like phenotype, implicating the NOD2–RIPK2 innate immune pathway as a key mediator of post‐surgical immune reprogramming. In contrast, the NOD2 agonist Mifamurtide has shown clinical efficacy when administered as adjuvant therapy to metastatic osteosarcoma patients after primary tumor resection. This data suggests that NOD/RIPK2 signaling may exert context-dependent effects, promoting either pro- or anti-tumor myeloid responses depending on the timing of activation relative to surgery. Understanding how surgical tumor removal alters systemic innate immunity and how RIPK2 signaling orchestrates these responses could identify new strategies to prevent early pulmonary relapse after surgery.

For more, visit: https://www.BishalSarkar.comMessage us directly: https://wa.me/918880361526In this episode of the “I Love Public Speaking” podcast, Bishal Sarkar reveals 3 powerful yet lesser-known techniques to instantly improve your voice modulation.You'll discover how to make your voice more dynamic, engaging, and impactful—whether you're speaking in a meeting, on stage, or on video.These tricks will help you command attention, avoid sounding flat or robotic, and keep your listeners fully engaged.If you want your voice to match your message's power, don't miss this episode.

BUFFALO, NY — April 2, 2026 — A new #research paper was #published in Volume 18 of Aging-US on March 24, 2026, titled “Age-specific relationship between the modulation of brain dynamics in response to task demands and bimanual performance.” Led by first author Sara Magalhães Ferreira from Hasselt University, with corresponding author Koen Cuypers from Hasselt University and KU Leuven, the study examined how age affects BOLD variability and its modulation with task demands during a bimanual task. The authors used fMRI in 22 younger and 23 older healthy adults who performed three increasingly complex task conditions. The authors found that older adults showed higher BOLD variability in cerebellar lobule VIIIb and greater modulation across task conditions in sensorimotor and cerebellar regions. Modulation of BOLD variability predicted performance in an age- and region-dependent manner: in younger adults, reduced modulation in sensorimotor and visuospatial areas correlated with better performance, whereas in older adults, increased modulation in the inferior and superior parietal lobules was linked to higher performance. Across groups, better outcomes were associated with greater modulation in the middle occipital gyrus but lower modulation in cerebellar Crus I. “In sum, this study highlights the potential role of BOLD variability modulation in shaping bimanual performance during aging.” The authors note that, while the age-related differences in BOLD dynamics were clear, they did not find robust evidence supporting a brain-behavior relationship in bimanual performance, which limits how directly the neural findings can be interpreted behaviorally. They recommend future work using multimodal imaging, longitudinal designs, and studies that examine both cognitive and motor domains within the same participants to determine whether variability modulation reflects aging, experience, intervention, or broader cross-functional signatures of aging. DOI - https://doi.org/10.18632/aging.206363 Corresponding author - Koen Cuypers - koen.cuypers@uhasselt.be Abstract video - https://www.youtube.com/watch?v=3TbcGFCZV9s Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206363 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, bimanual coordination, Bimanual Tracking Task, BOLD variability, task modulation To learn more about the journal, please visit https://www.Aging-US.com​​ and connect with us on social media at: Bluesky - https://bsky.app/profile/aging-us.bsky.social ResearchGate - https://www.researchgate.net/journal/Aging-1945-4589 X - https://twitter.com/AgingJrnl Facebook - https://www.facebook.com/AgingUS/ Instagram - https://www.instagram.com/agingjrnl/ LinkedIn - https://www.linkedin.com/company/aging/ Reddit - https://www.reddit.com/user/AgingUS/ Pinterest - https://www.pinterest.com/AgingUS/ YouTube - https://www.youtube.com/@Aging-US Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Explore the Circle of Interval Magicians and dive deeper into interval-based composition techniques: https://www.skool.com/circle-of-interval-magicians/about In this episode, Frank challenges the common advice of “just modulate” when composers feel stuck inside a scale. True freedom doesn't come from changing scales but from changing perspective. By using equal interval structures and moving them chromatically, composers can step outside traditional scale boundaries while maintaining clarity and coherence. Thinking in interval relationships rather than scale containers opens the door to greater creative control and expressive freedom.

Our understanding of how psychedelics work has evolved in meaningful ways over the past several years. While earlier neuroscience frameworks helped move the field forward, newer research has added important nuance and depth to how we interpret brain imaging, network behavior, and subjective experience.In this episode of The Trip Lab, I offer a refresh on psychedelic neuroscience, focusing on key updates from the past four years and how they change the story we tell about what's happening in the brain and the body during psychedelic states.We explore:How the Default Mode Network is better understood as dynamically modulated rather than simply reducedWhy psychedelic brain states are best described as time-varying and network-based rather than staticHow neural entropy is now understood as increased flexibility through relaxed constraintsWhy brain, body, and context are inseparable in shaping psychedelic experiences and outcomesThis episode is designed to update earlier explanations, clarify what has changed, and highlight why the newer neuroscience offers a more accurate and more interesting framework for understanding psychedelic effects.

Extended Producer Responsibility (EPR) is rapidly expanding into the textile industry, but how will it actually work in practice, and how can brands prepare?In this episode of HappyPorch Radio, Barry O'Kane speaks with Gerrard Fisher, co-founder of WEFT, a company helping brands understand the circularity of their products and prepare for future EPR systems.Gerrard explains how eco-modulation could link the design of products directly to the costs of dealing with them at the end of life. By analysing product data, brands can begin to see which materials, designs and product categories are easier to recycle and which could create higher costs in future circular systems.They also explore the broader opportunity of using this data not just to manage regulation, but to help guide product design, improve recycling infrastructure planning, and give consumers clearer information about sustainability.✨ In this episode:Gerrard explains how Extended Producer Responsibility works and why it's becoming a major issue for textilesWe explore eco-modulation and how it could financially reward products that are easier to recycle or more durable.Gerrard shares consumer research suggesting shoppers are surprisingly open to small EPR charges on clothing.We discuss how product data can help brands map the circularity of their portfolios and make better design decisions.Barry and Gerrard explore how WEFT prototyped its product using AI coding tools before building a more robust system.We discuss the importance of aligning incentives across policy, business and consumer behaviour to make circular systems work.

Today we're joined by Sean MacDonald, CEO of Kainova Therapeutics. With more than twenty years of biotech leadership and deep expertise in strategy and development, Sean is guiding the company through an exciting new chapter.We'll dive into Kainova's innovative GPCR-modulating platform, its promising pipeline, the science behind reversing tumor immunosuppression and targeting inflammation, and the reasons behind the recent rebrand from Domain Therapeutics to Kainova Therapeutics.We'll also be taking a look at the broader oncology landscape—what's hot, who's investing big, and where the biggest opportunities and challenges lie.01:09 – Meet Sean Macdonald05:40 – Kainova's GPCR platform and therapeutic focus08:57 – The story and meaning behind the Kainova rebrand10:25 – Series B funding and pipeline programs16:43 – Exciting trends and innovations in oncology29:17 – Upcoming milestones and future plansInterested in being a sponsor of an episode of our podcast? Discover how you can get involved here! Stay updated by subscribing to our newsletterTo dive deeper into the topic: GPCR therapies: Eight promising biotechs hacking the cell signaling pathwayEpisode 182: Building a smart oncology pipeline with Cumulus OncologyEpisode 34: eClinical Solutions, GPCR Therapeutics, Orbsen Therapeutics

PainExam Podcast Show Notes Red Light Therapy (Photobiomodulation) for Pain Evidence, Mechanisms, and Clinical Applications Host: Dr. David Rosenblum Red light therapy, also known as photobiomodulation (PBM) or low-level laser therapy (LLLT), is an emerging non-invasive treatment modality increasingly used in pain medicine, rehabilitation, and regenerative medicine practices. In this episode of the PainExam Podcast, Dr. Rosenblum reviews the mechanisms, clinical evidence, indications, and safety considerations surrounding photobiomodulation therapy for pain. Red and near-infrared wavelengths stimulate mitochondrial activity, increase ATP production, reduce inflammatory mediators, and promote tissue healing. These physiologic effects may translate into analgesic benefits for a variety of musculoskeletal and neuropathic pain conditions. Clinical research suggests potential benefit in temporomandibular disorders, chronic neck pain, and inflammatory oral conditions, though results vary due to differences in dosing parameters and treatment protocols. Despite these limitations, PBM has a favorable safety profile and is increasingly being integrated into multimodal pain management strategies. Key Topics Covered • What is photobiomodulation therapy (PBM) • How red and near-infrared light interact with mitochondria • Mechanisms of analgesia and tissue repair • Evidence from clinical trials in TMD, neck pain, and oral inflammatory pain • The biphasic dose response (Arndt-Schulz law) • Safety profile and contraindications • How PBM may integrate with regenerative pain medicine Mechanism of Action Photobiomodulation works primarily through stimulation of mitochondrial chromophores, particularly cytochrome c oxidase. This leads to: • Increased ATP production • Modulation of inflammatory cytokines • Increased angiogenesis and tissue repair • Reduced oxidative stress These effects may improve pain, inflammation, and healing in certain musculoskeletal conditions. Evidence Discussed in This Episode Temporomandibular Disorders Randomized trial demonstrating improvements in pain and mandibular function with red light therapy. De Carvalho et al., Pain Research and Treatment (2019) https://onlinelibrary.wiley.com/doi/full/10.1155/2019/8578703 Chronic Neck Pain Clinical trial demonstrating improvements in pain scores and pressure pain thresholds after photobiomodulation therapy. Chen et al., Lasers in Medical Science (2022) https://link.springer.com/article/10.1007/s10103-022-03540-0 Oral Pain and Dental Inflammation Randomized study demonstrating reduced pain and improved healing following PBM treatment. Almeida et al., BMC Oral Health (2023) https://link.springer.com/article/10.1186/s12903-023-02784-8 Who May Benefit From Photobiomodulation? Red light therapy may be considered as an adjunct treatment for: • myofascial pain • cervical spine pain • temporomandibular disorder • tendinopathy • peripheral neuropathy • musculoskeletal injury recovery Safety and Contraindications Photobiomodulation has a very favorable safety profile. Reported adverse effects are rare and usually mild: • transient erythema • warmth at treatment site • headache • eye irritation without proper protection Precautions include: • avoiding direct retinal exposure • avoiding treatment over malignancy • avoiding application over the uterus during pregnancy • caution in photosensitive disorders Resources For Patients Seeking Treatment Learn more about integrative and regenerative pain treatments including PRP, ultrasound-guided injections, and advanced pain therapies: AABP Integrative Pain Care & Wellness https://www.AABPpain.com For Pain Physicians and Advanced Practice Providers Training in ultrasound, interventional pain procedures, and pain board preparation: NRAP Academy CME Education https://www.NRAPpain.org

PainExam Podcast Show Notes Red Light Therapy (Photobiomodulation) for Pain Evidence, Mechanisms, and Clinical Applications Host: Dr. David Rosenblum Red light therapy, also known as photobiomodulation (PBM) or low-level laser therapy (LLLT), is an emerging non-invasive treatment modality increasingly used in pain medicine, rehabilitation, and regenerative medicine practices. In this episode of the PainExam Podcast, Dr. Rosenblum reviews the mechanisms, clinical evidence, indications, and safety considerations surrounding photobiomodulation therapy for pain. Red and near-infrared wavelengths stimulate mitochondrial activity, increase ATP production, reduce inflammatory mediators, and promote tissue healing. These physiologic effects may translate into analgesic benefits for a variety of musculoskeletal and neuropathic pain conditions. Clinical research suggests potential benefit in temporomandibular disorders, chronic neck pain, and inflammatory oral conditions, though results vary due to differences in dosing parameters and treatment protocols. Despite these limitations, PBM has a favorable safety profile and is increasingly being integrated into multimodal pain management strategies. Key Topics Covered • What is photobiomodulation therapy (PBM) • How red and near-infrared light interact with mitochondria • Mechanisms of analgesia and tissue repair • Evidence from clinical trials in TMD, neck pain, and oral inflammatory pain • The biphasic dose response (Arndt-Schulz law) • Safety profile and contraindications • How PBM may integrate with regenerative pain medicine Mechanism of Action Photobiomodulation works primarily through stimulation of mitochondrial chromophores, particularly cytochrome c oxidase. This leads to: • Increased ATP production • Modulation of inflammatory cytokines • Increased angiogenesis and tissue repair • Reduced oxidative stress These effects may improve pain, inflammation, and healing in certain musculoskeletal conditions. Evidence Discussed in This Episode Temporomandibular Disorders Randomized trial demonstrating improvements in pain and mandibular function with red light therapy. De Carvalho et al., Pain Research and Treatment (2019) https://onlinelibrary.wiley.com/doi/full/10.1155/2019/8578703 Chronic Neck Pain Clinical trial demonstrating improvements in pain scores and pressure pain thresholds after photobiomodulation therapy. Chen et al., Lasers in Medical Science (2022) https://link.springer.com/article/10.1007/s10103-022-03540-0 Oral Pain and Dental Inflammation Randomized study demonstrating reduced pain and improved healing following PBM treatment. Almeida et al., BMC Oral Health (2023) https://link.springer.com/article/10.1186/s12903-023-02784-8 Who May Benefit From Photobiomodulation? Red light therapy may be considered as an adjunct treatment for: • myofascial pain • cervical spine pain • temporomandibular disorder • tendinopathy • peripheral neuropathy • musculoskeletal injury recovery Safety and Contraindications Photobiomodulation has a very favorable safety profile. Reported adverse effects are rare and usually mild: • transient erythema • warmth at treatment site • headache • eye irritation without proper protection Precautions include: • avoiding direct retinal exposure • avoiding treatment over malignancy • avoiding application over the uterus during pregnancy • caution in photosensitive disorders Resources For Patients Seeking Treatment Learn more about integrative and regenerative pain treatments including PRP, ultrasound-guided injections, and advanced pain therapies: AABP Integrative Pain Care & Wellness https://www.AABPpain.com For Pain Physicians and Advanced Practice Providers Training in ultrasound, interventional pain procedures, and pain board preparation: NRAP Academy CME Education https://www.NRAPpain.org

PainExam Podcast Show Notes Red Light Therapy (Photobiomodulation) for Pain Evidence, Mechanisms, and Clinical Applications Host: Dr. David Rosenblum Red light therapy, also known as photobiomodulation (PBM) or low-level laser therapy (LLLT), is an emerging non-invasive treatment modality increasingly used in pain medicine, rehabilitation, and regenerative medicine practices. In this episode of the PainExam Podcast, Dr. Rosenblum reviews the mechanisms, clinical evidence, indications, and safety considerations surrounding photobiomodulation therapy for pain. Red and near-infrared wavelengths stimulate mitochondrial activity, increase ATP production, reduce inflammatory mediators, and promote tissue healing. These physiologic effects may translate into analgesic benefits for a variety of musculoskeletal and neuropathic pain conditions. Clinical research suggests potential benefit in temporomandibular disorders, chronic neck pain, and inflammatory oral conditions, though results vary due to differences in dosing parameters and treatment protocols. Despite these limitations, PBM has a favorable safety profile and is increasingly being integrated into multimodal pain management strategies. Key Topics Covered • What is photobiomodulation therapy (PBM) • How red and near-infrared light interact with mitochondria • Mechanisms of analgesia and tissue repair • Evidence from clinical trials in TMD, neck pain, and oral inflammatory pain • The biphasic dose response (Arndt-Schulz law) • Safety profile and contraindications • How PBM may integrate with regenerative pain medicine Mechanism of Action Photobiomodulation works primarily through stimulation of mitochondrial chromophores, particularly cytochrome c oxidase. This leads to: • Increased ATP production • Modulation of inflammatory cytokines • Increased angiogenesis and tissue repair • Reduced oxidative stress These effects may improve pain, inflammation, and healing in certain musculoskeletal conditions. Evidence Discussed in This Episode Temporomandibular Disorders Randomized trial demonstrating improvements in pain and mandibular function with red light therapy. De Carvalho et al., Pain Research and Treatment (2019) https://onlinelibrary.wiley.com/doi/full/10.1155/2019/8578703 Chronic Neck Pain Clinical trial demonstrating improvements in pain scores and pressure pain thresholds after photobiomodulation therapy. Chen et al., Lasers in Medical Science (2022) https://link.springer.com/article/10.1007/s10103-022-03540-0 Oral Pain and Dental Inflammation Randomized study demonstrating reduced pain and improved healing following PBM treatment. Almeida et al., BMC Oral Health (2023) https://link.springer.com/article/10.1186/s12903-023-02784-8 Who May Benefit From Photobiomodulation? Red light therapy may be considered as an adjunct treatment for: • myofascial pain • cervical spine pain • temporomandibular disorder • tendinopathy • peripheral neuropathy • musculoskeletal injury recovery Safety and Contraindications Photobiomodulation has a very favorable safety profile. Reported adverse effects are rare and usually mild: • transient erythema • warmth at treatment site • headache • eye irritation without proper protection Precautions include: • avoiding direct retinal exposure • avoiding treatment over malignancy • avoiding application over the uterus during pregnancy • caution in photosensitive disorders Resources For Patients Seeking Treatment Learn more about integrative and regenerative pain treatments including PRP, ultrasound-guided injections, and advanced pain therapies: AABP Integrative Pain Care & Wellness https://www.AABPpain.com For Pain Physicians and Advanced Practice Providers Training in ultrasound, interventional pain procedures, and pain board preparation: NRAP Academy CME Education https://www.NRAPpain.org

Dr. Ronald Lane, Founder of HOPE-Neuron Therapeutx, is developing an approach to treating ALS by rebalancing the body's immune system, which becomes dysfunctional in neurodegenerative diseases. The mechanism involves treating a patient's blood outside the body to activate the immune system and then infusing it back into the patient. The theory is that traditional drugs often fail because they target static genetic mutations and symptoms, while the source of the disease lies in the ongoing immune imbalance.  Ronald explains, "Well, in a broad sense, the goal of HOPE Neuron is based on the fact that our challenge here is to bring hope. And we use a neuronal basis to do that. We're not about drugs. There are no chemicals involved. We don't go that direction. But basically, it cuts across. We deal with memory, we deal with dementia and Alzheimer's, but our target initially is ALS."   "As I mentioned a moment ago, we're not doing drugs, we're not using chemicals. So what are you doing? Well, we're using the cell's immune system, and the problem with disease is that the immune system gets out of balance. When it's out of balance, you become ill. It can be in many different diseases. And there are certain indicators, and we know what to look for and what compounds the body generates."   #HOPENeuron #ALS #Neurology #ImmuneTherapy #MedicalInnovation #ALSResearch #Biotechnology #NeurodegenerativeDisease #MedicalBreakthrough #ClinicalTrials #Healthcare #Innovation #Neurodegeneration #Neuroplasticity #MedicalDevices #Immunotherapy #NeuroscienceInnovation #FutureOfMedicine #NonPharmaTherapies hopeneuron.com Download the transcript here

Dr. Ronald Lane, Founder of HOPE-Neuron Therapeutx, is developing an approach to treating ALS by rebalancing the body's immune system, which becomes dysfunctional in neurodegenerative diseases. The mechanism involves treating a patient's blood outside the body to activate the immune system and then infusing it back into the patient. The theory is that traditional drugs often fail because they target static genetic mutations and symptoms, while the source of the disease lies in the ongoing immune imbalance.  Ronald explains, "Well, in a broad sense, the goal of HOPE Neuron is based on the fact that our challenge here is to bring hope. And we use a neuronal basis to do that. We're not about drugs. There are no chemicals involved. We don't go that direction. But basically, it cuts across. We deal with memory, we deal with dementia and Alzheimer's, but our target initially is ALS."   "As I mentioned a moment ago, we're not doing drugs, we're not using chemicals. So what are you doing? Well, we're using the cell's immune system, and the problem with disease is that the immune system gets out of balance. When it's out of balance, you become ill. It can be in many different diseases. And there are certain indicators, and we know what to look for and what compounds the body generates."   #HOPENeuron #ALS #Neurology #ImmuneTherapy #MedicalInnovation #ALSResearch #Biotechnology #NeurodegenerativeDisease #MedicalBreakthrough #ClinicalTrials #Healthcare #Innovation #Neurodegeneration #Neuroplasticity #MedicalDevices #Immunotherapy #NeuroscienceInnovation #FutureOfMedicine #NonPharmaTherapies hopeneuron.com Listen to the podcast here

Send a textWhy are so many women still exhausted—even when they're eating well, sleeping more, and being told their labs look “normal”?In this episode of It's Hertime, Cody Sanders sits down with Dr. Evan Hirsch, also known as the EnergyMD, to unpack the real root causes behind chronic fatigue, long COVID, and persistent low energy in women. Drawing from both his personal health journey and clinical work, Dr. Hirsch explains why fatigue is rarely just about sleep or stress—and what actually needs to happen for true energy recovery.Together, Cody and Dr. Hirsch explore the systems-based drivers of fatigue, the role of nervous system dysregulation, and why many women feel worse when they try to “push through.” If you or someone you love feels tired all the time, wired but exhausted, or stuck in burnout despite doing all the right things, this conversation will bring clarity and hope.⸻In This Episode, You'll Learn:•The difference between being tired and having true chronic fatigue•Why standard lab work often misses the root causes of low energy•How long COVID and ME/CFS overlap with hormone and nervous system dysfunction•The EnergyMD Method and the “Toxic Five” contributors to fatigue•Why pushing harder with exercise can sometimes backfire•How nervous system regulation impacts energy, recovery, and resilience•The first steps women can take to start rebuilding real, sustainable energy⸻About Dr. Evan Hirsch (EnergyMD)Dr. Evan Hirsch is a fatigue expert who specializes in helping people recover from chronic fatigue syndrome, long COVID, and complex energy issues using a root-cause, functional medicine approach. After experiencing his own five-year battle with fatigue, he developed the EnergyMD Method to help patients systematically uncover and address the underlying drivers of low energy.Connect with Dr. Hirsch:•Free Fatigue Assessment: https://www.myfatiguescore.com•Website: https://www.energymdmethod.com•Book — Fix Your Fatigue: https://www.fixyourfatigue.org•Instagram: https://www.instagram.com/energymd•Facebook: https://www.facebook.com/EnergyMDMethod•YouTube: https://www.youtube.com/@EnergyMD⸻Work with Cody SandersIf this episode resonated and you're ready to stop guessing and start rebuilding your energy in a personalized, supportive way, Cody's signature CALM Body Reset program is designed specifically for women 40+ who feel exhausted, inflamed, and out of sync with their bodies.The CALM framework (Capacity, Adaptation, Load, Modulation) helps women move from survival mode to steady, sustainable energy through targeted nutrition, lifestyle, nervous system support, and root-cause investigation.Learn more about the CALM Body Reset here:DM "CALM" tDid you learn something new today? Be sure to subscribe to this podcast and share this episode with all the girls you love. We would appreciate it if you'd also leave us a rating and review on iTunes.Want to join our Mixhers Girl community and keep this conversation going? We'd love to hear your thoughts, feelings and experiences! Join us HERE!Join Mixhers email list and be the first to have access to new products and be the girl in the know!Follow Cody Instagram:@codyjeansanders

Explore the Circle of Interval Magicians. You find the Circle quickly by googling "Circle of Interval Magicians," or by following the link in the show notes. https://www.skool.com/circle-of-interval-magicians/about?ref=bfbebbc3d8d04a84806842a78f42963a Frank shares a surprising insight from the world of Hollywood scoring: most modern film scores are written in C concert with no key signature. Why? Because emotion demands constant modulation, and session players prefer clarity over tradition. By dropping the key signature, composers can let their harmony follow the picture more freely. Frank explains how this shift changed his own workflow and offers encouragement for composers looking to break free from rigid key thinking.

In this live episode from the AHR 2026 Podcast Pavilion, Bryan sits down with Copeland's Josh Souders (Manager of Commercial Unitary Product Management) and Jeff Kukert (Compression Senior Technical Trainer) to dive deep into Enhanced Vapor Injection (EVI) technology and its transformative impact on HVAC systems. This conversation offers both technical professionals and industry newcomers a comprehensive look at how vapor injection is revolutionizing heat pump performance, particularly in challenging climate conditions. The discussion centers on how EVI technology addresses one of the industry's most persistent challenges: maintaining high heat pump capacity in extremely low-temperature conditions. Josh and Jeff explain that vapor injection can deliver up to 20% added capacity and 10% improved efficiency while simultaneously enhancing compressor reliability. This technology, which has been a staple in refrigeration applications for years, is now becoming increasingly prevalent in commercial and residential HVAC systems, especially as cold climate heat pumps gain traction across North America. The guests make the complex topic accessible by breaking down how the system works—taking liquid refrigerant from the condensing line, running it through an expansion device and brazed plate heat exchanger (economizer), and injecting the cooled vapor directly back into the compressor scroll at a specific intermediate point. What makes this episode particularly valuable is the practical guidance offered for field technicians. The conversation moves beyond theoretical explanations to address real-world implementation challenges and troubleshooting strategies. Josh and Jeff emphasize the importance of understanding operating envelopes, pulse-width modulated (PWM) valves, pressure transducers, and modern control systems. They introduce Copeland's latest product developments, including the YAW variable speed vapor injection platform (1.5 to 25 tons) and the upcoming YAB two-stage vapor injection system launching later in 2026. The discussion also touches on applications beyond traditional HVAC, including commercial water heating and boiler replacement systems where high discharge temperatures are crucial. Throughout the episode, the guests maintain an encouraging tone toward technicians who may feel intimidated by these advancing technologies. They stress that while EVI systems may appear complex with additional tubing, heat exchangers, valves, and sensors, the underlying thermodynamic principles remain the same. The key is familiarizing oneself with new components like PWM valves and modern controllers, and leveraging tools like Copeland Mobile to verify system performance against operating envelopes. This episode serves as both an educational resource and a call to action for HVAC professionals to embrace these emerging technologies that are rapidly becoming industry standard. Topics Covered Enhanced Vapor Injection (EVI) fundamentals – How EVI works, its history in refrigeration, and why it's now critical for commercial and residential HVAC applications Capacity and efficiency benefits – Achieving up to 20% capacity boost and 10% efficiency improvement, particularly in low-ambient heating conditions Compressor reliability improvements – How injecting cooled vapor into the scroll set manages discharge temperatures and extends compressor life under high compression ratios Operating envelope management – Understanding compressor operational limits and using tools like Copeland Mobile to verify field conditions stay within safe parameters Cold climate heat pump technology – Meeting DOE's Cold Climate Heat Pump Challenge requirements for 100% capacity at 5°F ambient conditions System architecture and components – Detailed explanation of economizers (brazed plate heat exchangers), pulse-width modulated (PWM) valves, pressure transducers, and advanced controllers Compression ratio challenges – Managing the increased work required when outdoor temperatures drop while indoor condensing temperatures remain constant New Copeland product platforms – Introduction to YAW variable speed vapor injection (1.5-25 tons), YAB two-stage vapor injection (launching 2026), and tandem variable speed configurations Applications beyond traditional HVAC – Water heating systems, commercial boiler replacement, and managing high discharge temperatures for Legionella protection Technician training and tools – Practical advice on learning PWM valves, thermistors, transducers, and system controllers; emphasis on using Copeland Mobile for dynamic performance analysis Market trends and adoption – How vapor injection is becoming standard in premium residential systems and increasingly common across commercial rooftop units and dedicated outdoor air systems Installation and service considerations – Proper system design to avoid oversizing, humidity control in hot-humid climates, and troubleshooting techniques for complex control systems   Have a question that you want us to answer on the podcast? Submit your questions at https://www.speakpipe.com/hvacschool. Purchase your tickets or learn more about the 7th Annual HVACR Training Symposium at https://hvacrschool.com/symposium. Subscribe to our podcast on your iPhone or Android. Subscribe to our YouTube channel. Check out our handy calculators here or on the HVAC School Mobile App for Apple and Android.

Most talks are totally forgettable because they never land emotionally and logically. If you want real impact — the kind that people remember, repeat, and act on — you need to stop "delivering content" and start designing attention through voice, pacing, phrasing, and purposeful movement.  Why are most presentations forgettable, even when the content is "good"? Because information doesn't stick — impact does. Most presentations are heavy on data and light on connection, so audiences can't remember the speaker, the topic, or both, even a day later. In a post-pandemic, mobile-first attention economy (think 2020s Zoom fatigue plus constant notifications), your audience can disappear in seconds — two or three taps and they're in "distraction heaven". The irony is that many speakers feel impressive at the front of the room, but the audience experiences monotone delivery as a kind of "presenter white noise". Compare it to business: a strategy deck in a shared drive is rarely "scintillating", but a skilled leader can bring the same content alive through delivery. In Japan, Australia, the US, or Europe, the mechanism is the same: if the audience isn't touched (emotion + logic), the message doesn't travel. Do now (answer card): Impact = emotional + logical resonance. Design for attention, not just accuracy. How do you use word emphasis to make your message land? Emphasising key words changes meaning and makes ideas memorable. When every word is delivered with the same weight, your message flattens out — and audiences tune out. The fix is simple: stress the words that carry the intention. Take the phrase "This makes a tremendous difference." Hit different words and you get different implications: THIS(contrast), MAKES (causation), TREMENDOUS (scale), DIFFERENCE (outcome).  This works across contexts: whether you're a SaaS founder pitching in Singapore, a multinational leader briefing in Tokyo, or a sales director presenting to a procurement team in the US, emphasis helps listeners hear the headline inside the sentence. It's also an executive credibility tool: it signals certainty and prioritisation, not verbal mush. Do now (answer card): Pick 3–5 "load-bearing" words per section and punch them. Make your audience hear your priorities. Why do pauses increase attention (and stop people scrolling)? Pauses are a pattern interrupt that drags attention back to you. When you stop speaking, the contrast is so sharp that people who were mentally wandering snap back. That's why a well-timed pause creates anticipation — it makes the next sentence feel important. In live rooms it works because silence is social pressure; on video calls it works because silence is unusual and therefore noticeable. Most presenters under-use pauses because they fear awkwardness. But doubling the length of your current pauses — even in just two moments — increases impact because it forces processing time. It also reduces "verbal clutter" and improves perceived authority, especially for leaders and subject-matter experts who want to sound decisive rather than frantic. Do now (answer card): Add two deliberate pauses: one before your key point, one after it. Let the room absorb the idea.   How do pacing and modulation stop you sounding monotone? Variety in speed and strength keeps listeners engaged from start to finish. Pacing is your emphasis dial: slow down to spotlight meaning, speed up briefly for contrast, then return to normal. The goal isn't "fast talking" — it's controlled variation. A steady pace with no contrast becomes hypnotic in the wrong way. Modulation matters even more if your default delivery is flat. The article notes that Japanese is often described as a monotone language, which means speakers may need to inject extra variety through speed and strength to create highs and lows.   Think of a classical orchestra: if it only played crescendos or only soft lulls, it would be unbearable. Your voice needs both. Do now (answer card): Mark your script: SLOW (key line), FAST (brief energy burst), LOW (serious), HIGH (optimistic). Build contrast on purpose.   What makes phrasing memorable — and how do you create "sticky" lines? Memorable phrasing uses patterns the brain likes: alliteration, rhyme, and contrast. Great presenters don't just explain; they package. A simple shift like "hero to zero" sticks because it's rhythmic, punchy, and easy to repeat — which is the whole point.   When people repeat your phrase, your message travels without you. This is useful across roles: salespeople need repeatable value statements, executives need quotable strategy, and team leaders need language that anchors culture. In Japan vs. the US, the style may change (more subtle in Japan, more direct in the US), but the mechanics are universal: make it short, make it patterned, make it tied to an outcome. Do now (answer card): Create 2 "sticky lines" for your talk: a contrast pair (X to Y) and a rhythmic three-part phrase. How should you use movement and gestures without distracting people? Movement should have a purpose — otherwise it steals attention from your message. Gestures are powerful when they match what you're saying, because they add strength and clarity. But there's a rule: hold a gesture for a maximum of about 15 seconds; after that, its power drops and it becomes visual noise.  The bigger danger is pacing up and down like a caged tiger — it distracts audiences and looks like nervous energy, not leadership. In boardrooms, conference stages, and hybrid setups, the principle is the same: move to signal something (transition, emphasis, audience inclusion), then stop. Stillness can be as impactful as motion when it's intentional. Do now (answer card): Plan your movement: "I step forward for the key point, I step sideways for contrast, I stop for the close." No random wandering. Conclusion Communicating with greater impact isn't about being louder or more dramatic — it's about being more deliberate. When you combine word emphasis, pauses, pacing, modulation, memorable phrasing, and purposeful movement, you stop sounding like everyone else. And that's the real advantage: most speakers stay stuck in the same groove, losing their audience. You become the person who holds attention, lands the message, and strengthens your professional brand.  Author credentials Dr. Greg Story, Ph.D. in Japanese Decision-Making, is President of Dale Carnegie Tokyo Training and Adjunct Professor at Griffith University. He is a two-time winner of the Dale Carnegie "One Carnegie Award" (2018, 2021) and recipient of the Griffith University Business School Outstanding Alumnus Award (2012). As a Dale Carnegie Master Trainer, Greg is certified to deliver globally across leadership, communication, sales, and presentation programs, including Leadership Training for Results.  He has written several books, including three best-sellers — Japan Business Mastery, Japan Sales Mastery, and Japan Presentations Mastery — along with Japan Leadership Mastery and How to Stop Wasting Money on Training. His works have been translated into Japanese, including Za Eigyō (ザ営業) and Purezen no Tatsujin (プレゼンの達人).  Greg also publishes daily business insights on LinkedIn, Facebook, and Twitter, and hosts six weekly podcasts. On YouTube, he produces The Cutting Edge Japan Business Show, Japan Business Mastery, and Japan's Top Business Interviews, followed by executives seeking success strategies in Japan. 

Send us a textKann eine personalisierte Prähabilitation vor großen chirurgischen Eingriffen nicht nur die körperliche Leistungsfähigkeit, sondern auch das Immunsystem gezielt modulieren? In dieser Episode diskutieren wir eine randomisierte klinische Studie aus JAMA Surgery, die standardisierte mit personalisierten Prähabilitationsprogrammen vergleicht und zeigt, wie individualisierte, multimodale Interventionen präoperative Immunprofile, kognitive und physische Funktionen sowie postoperative Komplikationen beeinflussen.Cambriel A, Tsai A, Choisy B, et al. Immune Modulation by Personalized vs Standard Prehabilitation Before Major Surgery: A Randomized Clinical Trial. JAMA Surgery. Published online November 12, 2025.DOI: 10.1001/jamasurg.2025.4917Prähabilitation wird zunehmend als Strategie zur Verbesserung chirurgischer Outcomes diskutiert, ihre Wirksamkeit bleibt jedoch heterogen. In einer prospektiven, randomisierten, einfach verblindeten klinischen Studie untersuchten Cambriel et al. den Effekt einer personalisierten im Vergleich zu einer standardisierten Prähabilitation bei Patient:innen vor größeren elektiven Operationen.58 Patient:innen wurden 2–6 Wochen vor der Operation entweder einer papierbasierten Standard-Prähabilitation oder einer personalisierten, multimodalen Prähabilitation mit zweimal wöchentlichen individuellen Remote-Coachings (Bewegung, Ernährung, kognitives Training und Achtsamkeit) zugeteilt. Neben funktionellen und kognitiven Endpunkten wurde eine Immunphänotypisierung mittels 47-Parameter-Massenzytometrie durchgeführt.Die personalisierte Prähabilitation führte zu signifikanten Verbesserungen der körperlichen Leistungsfähigkeit (u. a. 6-Minuten-Gehtest, Timed-up-and-go-Test, Wandsitztest) sowie der kognitiven Funktion. Gleichzeitig traten signifikant weniger moderate bis schwere postoperative Komplikationen auf. Auf immunologischer Ebene zeigte sich eine ausgeprägte, zelltypspezifische Modulation des peripheren Immunsystems mit einer Dämpfung proinflammatorischer Signalwege (u. a. JAK/STAT- und MyD88-assoziierte Signale), die in früheren Studien mit postoperativen Komplikationen und neurokognitivem Abbau assoziiert waren.Die Ergebnisse legen nahe, dass personalisierte Prähabilitation nicht nur funktionelle Reserven stärkt, sondern auch biologische Mechanismen der chirurgischen Stressantwort gezielt beeinflusst und damit einen Ansatz für biologisch gesteuerte Risikostratifizierung und individualisierte präoperative Vorbereitung bietet.

Five articles from the December 2025 issue summarized in five minutes, with the addition of a brief editorial commentary. The 5-in-5 feature is designed to give readers an overview of articles that may pique their interest and encourage more detailed reading. It may also be used by busy readers who would prefer a brief audio summary in order to select the articles they want to read in full. The featured articles this month are: Reconstruction of the Medial Ulnar Collateral Ligament Using an Anatomic Technique With Suture Tape Augmentation to Allow for Expedited Return to Play in Throwing Athletes Fenofibrate Attenuates Rotator Cuff Muscle Fatty Infiltration via Modulation of the PPARα-FABP4 Pathway Meniscal Repair in the Setting of Revision Anterior Cruciate Ligament Reconstruction: 6-Year Follow-up Results From the MARS Cohort Does the Timing of Lysis of Adhesions After Anterior Cruciate Ligament Reconstruction Affect Final Range of Motion? Sports Participation in Patients With Hip Dysplasia Before and Up to 20 Years After Periacetabular Osteotomy Click here to read the articles.

CME credits: 0.25 Valid until: 02-12-2026 Claim your CME credit at https://reachmd.com/programs/cme/rethinking-schizophrenia-treatment-through-muscarinic-modulation/37103/ In this Chairperson's Perspective, Dr. Jose Rubio and Dr. Jonathan Meyer explore the evolving landscape of schizophrenia treatment through muscarinic receptor modulation. They compare the mechanisms of action, efficacy, and side effect profiles of muscarinic antipsychotics, such as xanomeline-trospium, with traditional dopamine D2 antagonists. The discussion addresses key clinical considerations for transitioning between dopaminergic and muscarinic therapies, including cholinergic burden and cross-titration timing. This expert dialogue provides relevant guidance for clinicians aiming to incorporate muscarinic therapies into personalized treatment plans for schizophrenia.=

For more, visit: https://www.BishalSarkar.comMessage us directly: https://wa.me/918880361526In this episode of the “I Love Public Speaking” podcast, Bishal Sarkar reveals 3 powerful yet lesser-known techniques to instantly improve your voice modulation.You'll discover how to make your voice more dynamic, engaging, and impactful—whether you're speaking in a meeting, on stage, or on video.These tricks will help you command attention, avoid sounding flat or robotic, and keep your listeners fully engaged.If you want your voice to match your message's power, don't miss this episode.

In this episode we meet Tony, K1KP, the developer of polar modulation that is being used in the new Flex Radio Aurora radio.  Polar modulation is a technology breakthrough that allows Flex Radio to make an integrated 500 watt HF/6m transciever, power supply and antenna tuner in a small light weight package.  With better than 80% efficiency, the Aurora produces less heat, consumes less power and is smaller than conventional radios.  Tony, K1KP, has been developing this technology for over 10 years.  In this episode we will hear about Tony's journey as he pioneered polar modulation in amateur radio.

Chris bell interviews Michael Arnold DNP, FHRS, about what is new in CCM therapy and when GDMT is not enough.

Dr. Kenneth Ellenbogen, Deputy Editor of JACC Clinical Electrophysiology discusses Pressure-Volume Analysis Demonstrates Short and Long-Term Hemodynamic Effects of Atrioventricular Interval Modulation Therapy in Hypertension.

Send us a textThis conversation is the first segment of SurfingMASH's July discussion of key events from the first six months of 2025. Co-hosts Jörn Schattenberg, Louise Campbell and Roger Green each chose one topic of personal interest.  Today, Jörn Schattenberg discusses two recent papers that demonstrate differences in how individual patients respond to different proteomic tests and what this can mean for individualized treatment plans. Jörn begins by citing Modulation of megabolic, inflammatory and fibrotic pathways by semaglutide in metabolic dysfunction-associated steatohepatitis, a paper from researchers at Novo Nordisk that Nature magazine posted online on July 21. In this paper, the researchers utilized proteomic testing (aptamer-based SomaSignal NASH tests) to determine whether semaglutide successfully addressed different NAS score elements: steatosis, lobular inflammation, hepatocyte ballooning and fibrosis. The proteomics-based tests indicated an improvement in all four of these elements, but the elements that improved and the amounts of improvement varied among individuals. To Jörn, this suggests that we can use an individual patient's proteomic results to tailor individualized therapy based on the areas in need of improvement, so that the prescriber would know whether the best approach to resolve NAS and reduce fibrosis was one that focused on metabolic issues vs. specific anti-fibrotic effects in the liver. He supports this idea by referring to a paper he had published in JHep Reports. In this paper, he and his colleagues looked at semaglutide Phase 1 and 2 obesity trials, where MASLD was not a criterion for entry. However, analyzing individual patients with the SomaLogic panel revealed that many had some form of MASLD and that semaglutide therapy could resolve the specific MASLD issues. The rest of the conversation focused on Jörn's conclusion and the potential for tailoring treatment plans to the individual. Lousie hailed the entire concept as extremely helpful not only in selecting a pharmacotherapy but also in providing patients with information they could use to improve their health further. Roger suggests that the kinds of proteomic tests Jörn describes can lead to first-line multi-agent pharmacotherapy to address the disease with agents that collectively will address the individual patient's profile. 

In this powerful episode of the Tick Boot Camp Podcast, we are joined by Dr. Daniel Warren of Envita Medical Center, a leading voice in the field of regenerative and integrative medicine, to break down the multi-layered complexity of chronic Lyme disease and its treatment. Dr. Warren takes us deep into the root causes of persistent symptoms, highlighting how chronic Lyme often results in immune dysregulation, biofilm-protected pathogens, co-infections, and central nervous system inflammation that go untreated by conventional protocols. The conversation explores the use of VSELS (Very Small Embryonic Like Stem Cells) to regenerate damaged tissue and rebalance immune function, as well as IRAD (Insulin Receptor Antibiotic Delivery)—Envita's proprietary method of delivering antibiotics past the blood-brain barrier to treat neurological Lyme disease. This episode is a must-listen for anyone seeking a deeper understanding of how precision diagnostics, immune modulation, and regenerative medicine can be integrated to support lasting recovery from chronic Lyme and tick-borne disease.

For more, visit: https://www.BishalSarkar.comMessage us directly: https://wa.me/918880361526In this episode of the “I Love Public Speaking” podcast, Bishal Sarkar reveals 3 powerful yet lesser-known techniques to instantly improve your voice modulation.You'll discover how to make your voice more dynamic, engaging, and impactful—whether you're speaking in a meeting, on stage, or on video.These tricks will help you command attention, avoid sounding flat or robotic, and keep your listeners fully engaged.If you want your voice to match your message's power, don't miss this episode.

JEMS Managing Editor Jeff Frankel sits down with occupational therapist Bonnie Ekman and paramedic leader Alanna Badgley to explore sensory modulation therapy as a breakthrough tool for first responders' mental health.   Bonnie explains how engaging all eight senses helps regulate the nervous system, moving beyond traditional talk therapy when first responders are stuck in fight-or-flight activation.   Alana shares her personal experience and the positive feedback from EMS professionals who have benefited from sensory rooms designed to soothe hypervigilance and stress.   They discuss practical, budget-friendly ways departments can implement sensory modulation spaces, emphasizing low-cost solutions like colored lighting, calming sounds, and tactile tools.

FATTY LIVER, OBESITY, TYPE-2 DIABETES AND FRQUENCY MODULATION-DR SHARRY EDWARDS

One of the things that helps us obey is knowing from whom the command comes, how much authority they have, and how much doing what they ask will matter. If the command comes from a coworker - it will not have the same impact as if it had come directly from the boss. Well, we have commands that have come directly from the Lord. To support this ministry financially, visit: https://www.oneplace.com/donate/1425/29

Everyone comes into the world as a baby but we mature - some faster than others!. The same is true spiritually. And too many in the Church have not matured. As we'll hear today, part of the problem is our low view of the Bible - that's why there is such a disinterest in the things of God. But the bible is the very word of God - when the bible speaks, God speaks. To support this ministry financially, visit: https://www.oneplace.com/donate/1425/29

In this episode of The ABMP Podcast, Whitney Lowe explores the powerful concept of descending modulation. Whitney breaks down the science behind this neurological process and how it applies directly to massage, manual therapy, and bodywork. Can therapeutic touch, trust, and context turn down the pain dial and support long-term healing? Tune in to find out.   Resources:   The Role of Descending Modulation in Manual Therapy and Its Analgesic Implications: A Narrative Reviewhttps://pubmed.ncbi.nlm.nih.gov/26788367/   The mechanisms of manual therapy in the treatment of musculoskeletal pain:https://www.sciencedirect.com/science/article/abs/pii/S1356689X08001598?via%3Dihub   Descending Modulation: Why Massage Therapy Can Alleviate Painhttps://massagefitnessmag.com/massage/descending-modulation-why-massage-therapy-alleviates-pain/#google_vignette   Recovery Strategies by Greg Lehmanhttps://www.greglehman.ca/recovery-strategies-pain-guidebook     Host:   Whitney Lowe is a known authority in the field of massage therapy, with a 36-year career marked by clinical work, research, publications, and teaching in advanced massage principles. He specializes in treating pain and injuries using massage and is one of the pioneers of the orthopedic massage approach. Lowe's Orthopedic Massage Program stands out in its engaging and accessible design and comprehensive curriculum. Students, whether learning online or in-person, praise Lowe for his approachable style and personalized training.   Sponsors:   Anatomy Trains: www.anatomytrains.com    American Massage Conference: www.massagetherapymedia/conferences   Earthlite: www.earthlite.com   Anatomy Trains is a global leader in online anatomy education and also provides in-classroom certification programs for structural integration in the US, Canada, Australia, Europe, Japan, and China, as well as fresh-tissue cadaver dissection labs and weekend courses. The work of Anatomy Trains originated with founder Tom Myers, who mapped the human body into 13 myofascial meridians in his original book, currently in its fourth edition and translated into 12 languages. The principles of Anatomy Trains are used by osteopaths, physical therapists, bodyworkers, massage therapists, personal trainers, yoga, Pilates, Gyrotonics, and other body-minded manual therapists and movement professionals. Anatomy Trains inspires these practitioners to work with holistic anatomy in treating system-wide patterns to provide improved client outcomes in terms of structure and function.                      Website: anatomytrains.com                        Email: info@anatomytrains.com             Facebook: facebook.com/AnatomyTrains                       Instagram: www.instagram.com/anatomytrainsofficial   YouTube: https://www.youtube.com/channel/UC2g6TOEFrX4b-CigknssKHA      American Massage Conference Get ready to immerse yourself in the excitement as the American Massage Conference (AMC) arrives to Disney Springs near Orlando, Florida (May 16th-18th, 2025)! With a legacy of 17 successful years in Ontario, Canada, this premier event, proudly hosted by ONE Concept Conferences and expertly produced by Massage Therapy Media (MTM), boasts a lineup of presenters from across the nation and around the globe. The American Massage Conference began in Atlanta in 2011 and has been hosted through the years in San Diego, Chicago, and Virginia Beach. The conference provides educational opportunities with engaging one-, two-, three- and four-hour class formats, networking opportunities, masterminds, MTM Talks, demonstrations, and an extensive exhibitor tradeshow.   Mark your calendars for an unforgettable experience filled with education, networking, and the celebration of massage therapy excellence! ABMP members receive a special discount to attend this in-person conference—log in to your ABMP account to access the discount code and register today. Website: https://www.massagetherapymedia.com/conferences   Earthlite Unlock an exclusive 20 percent discount on all Earthlite products, from portable tables and chairs to professional sheets and oils. Visit earthlite.com, create an account, and enter your ABMP member ID during registration. Plus, enjoy free ground shipping on orders over $75 and a flat rate of $395 for stationary or electric lift tables. (Prices subject to change at any time.) Significant savings on everything you need to enhance your practice. We are proud to assist you as the “World's No. 1 Brand in Massage!”   Sign-up page: https://www.earthlite.com/customer/account/login/referer/aHR0cHM6Ly93d3cuZWFydGhsaXRlLmNvbS8~/  

"When I first listened to the field recording, I was drawn to its spatial rendering, which made me curious to learn more about the place and its surroundings. Historically, it functioned both as an orphanage and a hospital, with certainly thousands traces of stories. This history, along with the architecture, inspired me to explore the relational characteristics of frequencies, materials, and memories. Also, I've always been fascinated by how a cathedral's dome is designed to shape frequencies, creating what could be described as "the song of the angels.". So I started to engage with the volume and height of the space, imagining how sound might behave within it—how frequencies would rapidly reflect across various distances, spreading in all directions within the massive structure of the Hospicio Cabañas in Guadalajara. "I think I engaged with Sonic Heritage by focusing on the relational and spatial aspects of sound within historically and culturally significant environments. By interpreting and exploring the acoustics of Hospicio Cabañas, I consider how sound interacts with architecture and memory, emphasizing how sonic imprints persist in spaces with deep historical resonance. "I used only the field recording as the primary material, processing it in SuperCollider. I enjoy the forensic nature of coding, allowing me to dissect sound and explore its possibilities. "A personal anecdote — I'm not entirely sure, but having worked as a painting restorer, I've become familiar with the spaces and atmospheres of historical monuments, particularly the sacred ones." Hospicio Cabañas at Guadalajara reimagined by Thierry J.D. Bernard. ——————— This sound is part of the Sonic Heritage project, exploring the sounds of the world's most famous sights. Find out more and explore the whole project: https://www.citiesandmemory.com/heritage

Episode 139: Definitive Guide To Modulation Pedals: Types, Sounds, and Signal Path Strategies Welcome to the Chairmen of the Boards Podcast! The ultimate pedalboard podcast with the foremost rig builders in the world: Grant Klassen (Goodwood Audio), Brian Omilion (Omilion Audio), and Mason Marangella (Vertex Effects/The Rig Doctor). We've teamed up to democratize great tone and provide you with our best tricks, tips, resources and hacks so you can build the pedalboard of your dreams!   //SPONSORS// The Guitar Sanctuary - https://theguitarsanctuary.com Neural DSP - https://www.neuraldsp.com (use discount code "chairmen" for 30% off) Best-Tronics - https://btpa.com (use code "dachairs" for 10% off) GB Music & Sound - https://www.gbmusicandsound.com/?ref=Chairmen   //HOSTS// Grant Klassen (Goodwood Audio) YT - ‪@GoodwoodAudio‬ IG - https://instagram.com/goodwoodaudio   Brian Omilion (Omilion Audio) YT - ‪@omilionaudio‬ IG - https://instagram.com/omilionaudio   Mason Marangella (Vertex Effects) YT - ‪@VertexEffectsInc‬ IG - https://instagram.com/vertexeffects   //YOUTUBE// Watch COTB Podcast live: @chairmenoftheboards

Welcome to Season 2 of the Orthobullets Podcast.Today's show is Podiums, where we feature expert speakers from live medical events. Today's episode will feature ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Dr. ⁠⁠⁠Thomas Best⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠and is titled⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Arthritis Institute Focus On Modulation of Arthritis.⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Follow⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Orthobullets⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ on Social Media:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Facebook⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Instagram⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Twitter⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠LinkedIn⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠YouTube

Hello dear listener, Welcome back! It's episode 2, it's season 6, it's 10 years-ish of Nerdery! This week Matt and I are lamenting not being at NAMM and taking a look at some of the best new releases so far. First up, we'll be taking a look at and a listen to the new Kernom Elipse - a multi-modulation pedal with some unique controls and fun effect mashing options! Hosted on Acast. See acast.com/privacy for more information.

Ads for Ozempic, Wegovy, and Zepbound are all over our televisions (at least here in the US). But are these injectables really the key to losing weight and keeping it off? In this episode, I'm digging into all of the science surrounding these popular weight-loss drugs, including - the differences between each of them - how they work (and don't work) - the unwanted side effects that come from using these medications - natural ways to increase your body's production of GLP-1 ... and more! --- Show Notes: References: Coursework from Master's in Human Nutrition & Functional Medicine Program at the University of Western States Efficacy and safety of GLP-1 receptor agonists versus SGLT-2 inhibitors in overweight/obese patients with or without diabetes mellitus: a systematic review and network meta-analysis Weight regain and cardiometabolic effects after withdrawal of semaglutide: The STEP 1 trial extension Weight Loss Medications: GLP-1 Agonists and How They Work How Much Does Ozempic Cost? With & Without Insurance Zepbound vs. Ozempic: 5 Differences Between These Weekly Injections What Are Incretin Mimetics, and How Do They Affect Weight Loss, Blood Sugar, and Type 2 Diabetes? Strategies for minimizing muscle loss during use of incretin‐mimetic drugs for treatment of obesity The Positive Effects of Yerba Maté (Ilex paraguariensis) in Obesity Anti-obesity effects of Yerba Mate (Ilex Paraguariensis): a randomized, double-blind, placebo-controlled clinical trial The effect of psyllium on fasting blood sugar, HbA1c, HOMA IR, and insulin control: a GRADE-assessed systematic review and meta-analysis of randomized controlled trials Soluble fibers from psyllium improve glycemic response and body weight among diabetes type 2 patients (randomized control trial) Increased glucagon-like peptide-1 secretion may be involved in antidiabetic effects of ginsenosides Modulation of glucagon-like peptide-1 release by berberine: in vivo and in vitro studies The effects of berberine on inflammatory markers in Chinese patients with metabolic syndrome and related disorders: a meta‑analysis of randomized controlled trials Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins A High Dose of Dietary Berberine Improves Gut Wall Morphology, Despite an Expansion of Enterobacteriaceae and a Reduction in Beneficial Microbiota in Broiler Chickens Berberine enhances the AMPK activation and autophagy and mitigates high glucose-induced apoptosis of mouse podocytes Curcumin induces secretion of glucagon-like peptide-1 through an oxidation-dependent mechanism --- 135: What You Should Know Before Starting Ozempic Sign up for a 1:1 Discovery Call Join the Compass Method DIY Program Jump inside my Rock the Bloat Minicourse Get my Core-Gi Workout Program with the exclusive listener discount! Join my Brain Rewiring Masterclass You can learn more about me by following on IG @imperfectlypaigewellness or by checking out my blog, freebies, and offers on my website: https://imperfectlypaigewellness.com Please share with #PaigeTalksWellness to help get the word out about the show - and join the Imperfect Health Fam over on Facebook.

A powerful ancient remedy is gaining modern attention, and it's as simple as drinking clove water before bed. Studies suggest it might improve digestion, support immunity, and even help you sleep better! Curious how? Let's dive in! We'll explore the science-backed reasons why clove water is a nighttime game-changer, how to make it, and precautions to take.  What Is Clove Water and Why at Night? What is clove water? Made by steeping cloves in water to extract active compounds like eugenol, flavonoids, and tannins. Why at night? Optimal absorption: The body focuses on repair and recovery during sleep, allowing active compounds to work effectively. Evening consumption aids digestion after your last meal and preps the body for restful sleep.

Time to sit down and write you a letter. www.cocktailnation.net Johnny Mandel- Letter Writing Sequence Charles Fox - A Moment to Share The 5th Dimension- One Less Bell To Answer Marcos Valle- The Answer Diahann Caroll -Don't Answer Me (Ti Vedo Uscire) Melanchrino Strings-Answer Me My Love Polly Bergen -All Alone Beegie Adair-Let's Get Lost Dianne Reeves- Social Call Eliane Elias- Call Me Dean Martin- I'm Gonna Sit Right Down (And Write Myself A Letter) Jeri Southern- My Letters Chet Baker- Crazy She Calls Me James Spencer- Love Letters Jackie Gleason- Love Letters In The Sand Larry Newcombe- Essential Messengers MPS- Lost in Modulation

Dannic - All Mine (Extended Mix) DONT BLINK - MODULATION Claw & Zane - Welcome To The Rave (Instrumental Extended Mix) Joachim Garraud & Friends - HWBBIHC The Chemical Brothers - Hey Boy Hey Girl (ARTBAT Remix) [Extended Mix] Quench - Dreams (Joachim Garraud Remix) Joachim Garraud & Friends - BHAWXRR Meetch - Feel It Marten Hørger - Don't Stop (Extended Mix) Joachim Garraud & Friends - MJYRSTS LUMBERJACK - Welcome To The Game (Extended Mix) DJ Yasmin & HΛNNΛH X - Clap Anthem (Extended Mix) Anti Up - Set Me Free HAUS OF PANDA & USE CAUTION - IN MY HAUS Violate_(Extended_Mix) Joachim G.- Proud Mosher Sebastian Mora - Anasthasia

Did you know that you can modify your rest periods to create more intense workouts without having to increase weight or reps?  Did you know that "rest periods" also refers to the time between similar movements?  Want to learn more specifics and fun ways to create more workout variety?  Listen in!!!

Today, we're talking about something that might surprise you—we're going to talk about Botox.  If you're asking, “Why are we discussing Botox on a podcast focused on mental health?” Another centerpiece to this podcast is talking about ways to support, heal and regulation your nervous systems, in that it's important to consider how everything we do—including something as common as a Botox—could play a role. Today we'll talk about both the cosmetic & medical uses of Botox as we talk through it's benefits and it's potential impact on your nervous system, brain, and emotional regulation (potentially of you and your kids). Hit play to learn more!Here's the 3 takeaways:Botox is a neurotoxin. It is used both medically & cosmetically. Most of the research show's it's more safe than not but that doesn't mean there aren't risks and side effects. Do you feel aligned with how or why you choose Botox? Does it improve that quality of your life in a way that outweighs potential costs?Potential costs of botox include muscle atrophy, changes in brain activity, and emotional regulation - with potential implication for both you and your children's emotional literacy.Long-term effects of Botox are not fully understood.Sources mentioned:Stark, S., Stark, C., Wong, B. et al. Modulation of amygdala activity for emotional faces due to botulinum toxin type A injections that prevent frowning. Sci Rep 13, 3333 (2023). Davis JI, Senghas A, Brandt F, Ochsner KN. The effects of BOTOX injections on emotional experience. Emotion. 2010 Jun;10(3):433-40. doi: 10.1037/a0018690. PMID: 20515231; PMCID: PMC2880828.Weise D, Weise CM, Naumann M. Central Effects of Botulinum Neurotoxin-Evidence from Human Studies. Toxins (Basel). 2019 Jan 6;11(1):21. doi: 10.3390/toxins11010021. PMID: 30621330; PMCID: PMC6356587.BBC Article: Are there long-term health risks to using Botox?Looking for more personalized support?Book a FREE consultation for RESTORE, our 1:1 anxiety & depression coaching program.Join me inside RISE, a mental health membership and nervous system healing space.Order my book, Healing Through the Vagus Nerve today!Want me to talk about something specific on the podcast? Let me know HERE.Website: https://www.riseaswe.com/podcastEmail: amanda@riseaswe.comInstagram: https://www.instagram.com/amandaontherise/TikTok: https://www.tiktok.com/@amandaontherise

In this episode, we explored ozone insufflation, a lesser-known therapy that's gaining attention for its potential benefits in supporting the health of breast cancer survivors. Ozone, a molecule made up of three oxygen atoms, is commonly known for its role in the atmosphere, but in a medical setting, it can be used to help our bodies in various ways. I'll break down how ozone therapy works, and share some fascinating research findings with you. If you're interested in a non-toxic therapy that helps with pain relief and tissue repair, might reduce the harmful side effects of chemotherapy, and can support our immune system. This episode is for you. While ozone insufflation shows promise, it's important to remember that it should be used under professional guidance to ensure it's right for your individual needs. Overall, this therapy could be an interesting addition to your wellness toolkit, helping you feel more supported on your path to recovery. Every very step we take toward supporting our health is a step in the right direction.   Referred to in this episode: Better Than Before Breast Cancer™ Life Coaching Membership Ozone therapy in musculoskeletal medicine: a comprehensive review Modulation of Oxidative Stress by Ozone Therapy in the Prevention and Treatment of Chemotherapy-Induced Toxicity: Review and Prospects Systemic Ozone Therapy by Rectal Insufflation for Immunoglobulin A Deficiency MATC trained Doctors Follow me on Social Media:  Facebook Instagram Pinterest YouTube  

Eric Edmeades explains how voice modulation is key for engaging audiences. He advises becoming "trilingual" in communication by mastering auditory, visual, and kinesthetic voice modes to connect with different listener preferences.

Wellness + Wisdom | Episode 658 Are your probiotics helping you heal your gut or are you just wasting your money? Tina Anderson, Co-Founder of Just Thrive, joins Josh Trent on the Wellness + Wisdom Podcast, episode 658, to explain why most probiotics are not real probiotics, how spore-based probiotics heal the gut microbiome, why gut health is essential for your mental health and brain function, and what the healing protocol for the gut consists of.   "99.99% of probiotics die by the time they get to the intestines. If a probiotic needs to be refrigerated in order to stay alive, it wouldn't even survive on the store shelf which means it could never survive your body temperature. Spore-based probiotic has this endospore shell around itself which allows it to be a very hardy organism and survive the journey from the mouth through the gastric system into the intestines." - Tina Anderson 20% Off Just Thrive Probiotics There are hundreds of brands of probiotics on the market, but as you've probably already discovered, they are not all equal. Just Thrive® is the first 100% spore-forming probiotic and antioxidant supplement that arrives 100% alive to your intestines that's available in the retail market. Just Thrive® contains a patented strain called Bacillus Indicus HU36® – bacillus strains are abundant environmental organisms that are a normal part of the human microflora. This strain, Bacillus Indicus HU36®, produces antioxidants/ carotenoids (the nutrients that give red peppers and tomatoes their color) in your intestines where they can be best absorbed by the body, making it one of the most absorbable forms of antioxidants on the market. These spores have been successfully used to enhance digestive health for more than 50 years! 20% off with code "JOSH" In This Episode, Tina Anderson Uncovers: [01:30] Gut Imbalances Are The Cause of Disease Tina Anderson Just Thrive - 20% off with the code JOSH 360 Tina Anderson | Gut Health: The New Probiotic Strain That Changes Everything Why people have been taking more control over their health since 2020. How every disease is related to gut imbalances. [05:30] Pharmaceuticals: A Bandage for Symptoms Why Tina shifted from litigation to the pharmaceutical industry. How doctors are encouraged to prescribe medications even if the patients don't need them. Why we always need to identify the root cause of an illness. [08:50] Spor-Based Probiotics How Tina never compromised her family and business but compromised her own needs. Why people buy supplements. What motivated Tina and her husband to create the first spore-based probiotics. Why probiotics don't need to be refrigerated. Most probiotic strains die by the time they reach the stomach. [16:20] Most Probiotics Are Not Real Probiotics What helped them decide if they're going to start Just Thrive. Why probiotics need to be able to stay alive in the intestines. How we used to get spores from the soil. Why the two most common probiotic strains are not what the body needs. [22:05] Return to Nature Why doctors in Japan prescribe time in nature to their patients. How spore probiotics helped an autistic child to improve his life. Reactive and responsive health models. Modulation of Gut Microbiota and Immune System by Probiotics, Pre-biotics, and Post-biotics [27:35] Gut-Brain Axis The brain sends signals to the gut and the gut sends signals to the brain. 90% of serotonin is produced in the gut. How stress sends information to the stomach. Why allergies are more common now than ever before. How reducing bacteria in the environment causes harm. [31:50] The Healing Protocol for The Gut How our food is being poisoned. What we can do to protect and heal our gut. How antibiotics lower the immune system function. Why meditation is an important factor in healing the gut microbiome. How exposure to new types of foods is good for gut health. [36:55] What Causes Chronic Disease Why so many people struggle with leaky gut. How spore-based probiotics remove LPS toxins from the gut. An imbalanced gut microbiome can lead to autoimmune disease. Why inflammation is the main cause of chronic disease. [41:50] Why Children Are Sick Why we shouldn't always listen to the doctor. How Big Pharma education is misleading people. Why yogurt is not always good for gut health. There is an epidemic of children's disease. How the mother influences her child's microbiome during pregnancy and birth. 638 Tiny Health: Healing Family Gut Dysbiosis + The Missing Link Between Child Chronic Condition Crisis (Cheryl Sew Hoy) [49:15] New Perspective on Health How nature provides healing. Why a doctor in Serbia prescribed a girl to go to the sea to heal. The importance of applying common sense to our health. Why we need to search for new perspectives if we want to heal. [55:50] Probiotic Myths Why the gut is constantly under attack. The side effects of Just Thrive are better mood and sleep. Why the amount of probiotic strains doesn't mean the probiotics are better. The importance of diversity in the gut microbiome.   Leave Wellness + Wisdom a Review on Apple Podcasts