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Rig Doctor Podcast: Tone Tips, Pedalboard Tricks, & Easy DIY Hacks
Episode 139: Definitive Guide To Modulation Pedals: Types, Sounds, and Signal Path Strategies Welcome to the Chairmen of the Boards Podcast! The ultimate pedalboard podcast with the foremost rig builders in the world: Grant Klassen (Goodwood Audio), Brian Omilion (Omilion Audio), and Mason Marangella (Vertex Effects/The Rig Doctor). We've teamed up to democratize great tone and provide you with our best tricks, tips, resources and hacks so you can build the pedalboard of your dreams! //SPONSORS// The Guitar Sanctuary - https://theguitarsanctuary.com Neural DSP - https://www.neuraldsp.com (use discount code "chairmen" for 30% off) Best-Tronics - https://btpa.com (use code "dachairs" for 10% off) GB Music & Sound - https://www.gbmusicandsound.com/?ref=Chairmen //HOSTS// Grant Klassen (Goodwood Audio) YT - @GoodwoodAudio IG - https://instagram.com/goodwoodaudio Brian Omilion (Omilion Audio) YT - @omilionaudio IG - https://instagram.com/omilionaudio Mason Marangella (Vertex Effects) YT - @VertexEffectsInc IG - https://instagram.com/vertexeffects //YOUTUBE// Watch COTB Podcast live: @chairmenoftheboards
Lebendige Rhetorik - Der Podcast für Rhetorik & Kommunikation
Ich bin gesundheitlich angeschlagen und merke gerade am eigenen Leib, wie wichtig die Stimme ist, um z.B. eine Podcastfolge aufzunehmen. Und wie wenig überzeugend ich dir gerade neue, spannende Inhalte vermitteln könnte. Also müssen diese warten und du darfst dir eine nicht minder spannende, aber schon etwas ältere Folge im Reload anhören, in der es um den optimalen Einsatz deiner Stimme geht. Vor allem um -> Sprechgeschwindigkeit -> Lautstärke -> Modulation -> Pausen Ich schon meine Stimme für die nächste Folge.
Welcome to Season 2 of the Orthobullets Podcast.Today's show is Podiums, where we feature expert speakers from live medical events. Today's episode will feature Dr. Thomas Best and is titledArthritis Institute Focus On Modulation of Arthritis.FollowOrthobullets on Social Media:FacebookInstagram TwitterLinkedInYouTube
Hello dear listener, Welcome back! It's episode 2, it's season 6, it's 10 years-ish of Nerdery! This week Matt and I are lamenting not being at NAMM and taking a look at some of the best new releases so far. First up, we'll be taking a look at and a listen to the new Kernom Elipse - a multi-modulation pedal with some unique controls and fun effect mashing options! Hosted on Acast. See acast.com/privacy for more information.
Ads for Ozempic, Wegovy, and Zepbound are all over our televisions (at least here in the US). But are these injectables really the key to losing weight and keeping it off? In this episode, I'm digging into all of the science surrounding these popular weight-loss drugs, including - the differences between each of them - how they work (and don't work) - the unwanted side effects that come from using these medications - natural ways to increase your body's production of GLP-1 ... and more! --- Show Notes: References: Coursework from Master's in Human Nutrition & Functional Medicine Program at the University of Western States Efficacy and safety of GLP-1 receptor agonists versus SGLT-2 inhibitors in overweight/obese patients with or without diabetes mellitus: a systematic review and network meta-analysis Weight regain and cardiometabolic effects after withdrawal of semaglutide: The STEP 1 trial extension Weight Loss Medications: GLP-1 Agonists and How They Work How Much Does Ozempic Cost? With & Without Insurance Zepbound vs. Ozempic: 5 Differences Between These Weekly Injections What Are Incretin Mimetics, and How Do They Affect Weight Loss, Blood Sugar, and Type 2 Diabetes? Strategies for minimizing muscle loss during use of incretin‐mimetic drugs for treatment of obesity The Positive Effects of Yerba Maté (Ilex paraguariensis) in Obesity Anti-obesity effects of Yerba Mate (Ilex Paraguariensis): a randomized, double-blind, placebo-controlled clinical trial The effect of psyllium on fasting blood sugar, HbA1c, HOMA IR, and insulin control: a GRADE-assessed systematic review and meta-analysis of randomized controlled trials Soluble fibers from psyllium improve glycemic response and body weight among diabetes type 2 patients (randomized control trial) Increased glucagon-like peptide-1 secretion may be involved in antidiabetic effects of ginsenosides Modulation of glucagon-like peptide-1 release by berberine: in vivo and in vitro studies The effects of berberine on inflammatory markers in Chinese patients with metabolic syndrome and related disorders: a meta‑analysis of randomized controlled trials Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins A High Dose of Dietary Berberine Improves Gut Wall Morphology, Despite an Expansion of Enterobacteriaceae and a Reduction in Beneficial Microbiota in Broiler Chickens Berberine enhances the AMPK activation and autophagy and mitigates high glucose-induced apoptosis of mouse podocytes Curcumin induces secretion of glucagon-like peptide-1 through an oxidation-dependent mechanism --- 135: What You Should Know Before Starting Ozempic Sign up for a 1:1 Discovery Call Join the Compass Method DIY Program Jump inside my Rock the Bloat Minicourse Get my Core-Gi Workout Program with the exclusive listener discount! Join my Brain Rewiring Masterclass You can learn more about me by following on IG @imperfectlypaigewellness or by checking out my blog, freebies, and offers on my website: https://imperfectlypaigewellness.com Please share with #PaigeTalksWellness to help get the word out about the show - and join the Imperfect Health Fam over on Facebook.
A powerful ancient remedy is gaining modern attention, and it's as simple as drinking clove water before bed. Studies suggest it might improve digestion, support immunity, and even help you sleep better! Curious how? Let's dive in! We'll explore the science-backed reasons why clove water is a nighttime game-changer, how to make it, and precautions to take. What Is Clove Water and Why at Night? What is clove water? Made by steeping cloves in water to extract active compounds like eugenol, flavonoids, and tannins. Why at night? Optimal absorption: The body focuses on repair and recovery during sleep, allowing active compounds to work effectively. Evening consumption aids digestion after your last meal and preps the body for restful sleep.
J'ai exploré dans cet épisode avec notre confrère Nicolas Perret, médecin généraliste, maître de stage universitaire et hypnothérapeute, l'univers fascinant de l'hypnose. Découvrez comment cette pratique peut transformer votre approche médicale et améliorer le bien-être de vos patients.
Dana Rizk, MD - Unlocking the Potential of B-Cell Modulation Therapies in IgA Nephropathy
Dana Rizk, MD - Unlocking the Potential of B-Cell Modulation Therapies in IgA Nephropathy
J'ai exploré dans cet épisode avec notre confrère Nicolas Perret, médecin généraliste, maître de stage universitaire et hypnothérapeute, l'univers fascinant de l'hypnose. Découvrez comment cette pratique peut transformer votre approche médicale et améliorer le bien-être de vos patients.
Mike Speed | React Radio UK Show | www.reactradio.uk | Underground & Oldskool Beats
Mike Speed | Modulation | The Loft | Cleckheaton | 301124 | Set 4 | LIVE Recording
Immunology is a key area in biotech and biopharma, both in terms of R&D and sales.However, according to UK-headquartered Greywolf Therapeutics, the industry has only focused on two-thirds of the puzzle.To have an immunological effect, you must activate the body's T cells, which cells requires a chain of three key signals. The first is antigen recognition, i.e. the initial detection of a cell by a T-cell. The second is the co-stimulation of non-antigen presenting molecules, which enhances the immune response. The final step is cytokine-mediated differentiation and expansion, which guides how T-cells target threats. Companies have focused on the second two signals, with signal 2 most commonly seen in therapies such as checkpoint inhibitors and monoclonal antibodies. Signal 3, on the other hand, can be primarily seen in therapies for autoimmune disorders, such as anti-TNF and JAK inhibitors.Greywolf Therapeutics is the first company to explore changing signal 1. The company says focusing on signal 1 applies in three key therapeutic areas: oncology, autoimmunity and virology. Greywolf's first candidate has delivered a robust response during its ongoing phase I/II trial in oncology, therefore demonstrating proof-of-mechanism and target engagement, with its next candidate well-progressed in preclinical development in autoimmunity.To tell us more about the company and its work is Pete Joyce, CEO and co-founder of Greywolf Therapeutics.01:19-04:12: About Greywolf Therapeutics04:12-04:51: The origins of the name04:51-06:52: The three ‘signals' of the mechanics of immunological responses06:52-08:31: Treatments associated with each signal08:31-10:09: Why is step 1 important, and why has it not been investigated for treatments?10:09-11:28: What areas of disease is this applicable to?11:28-12:19: How do you inhibit ERAP?12:19-14:01: Greywolf Therapeutics' candidates14:01-15:11: How is this an advance on current treatments?15:11-16:05: What is success for patients?16:05-17:20: How does the stage of disease affect treatment?17:20-18:09: Are other companies looking into antigen modulation? 18:09-19:47: Has this led to investment opportunities?19:47-21:15: Next steps21:15-21:55: Do you anticipate more interest in this space?21:55-23:21: Attending events Interested in being a sponsor of an episode of our podcast? Discover how you can get involved here! Stay updated by subscribing to our newsletter
References Nature Communications 2023.volume 14. Article number: 794 Guerra, DJ.2024 Lecture notes Mozart, WA. 1781. Serenade in B Flat " Gran Partita" K.361 https://youtu.be/BbjpuMid8DE?si=52qNaebE0gZcVK-h --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
Time to sit down and write you a letter. www.cocktailnation.net Johnny Mandel- Letter Writing Sequence Charles Fox - A Moment to Share The 5th Dimension- One Less Bell To Answer Marcos Valle- The Answer Diahann Caroll -Don't Answer Me (Ti Vedo Uscire) Melanchrino Strings-Answer Me My Love Polly Bergen -All Alone Beegie Adair-Let's Get Lost Dianne Reeves- Social Call Eliane Elias- Call Me Dean Martin- I'm Gonna Sit Right Down (And Write Myself A Letter) Jeri Southern- My Letters Chet Baker- Crazy She Calls Me James Spencer- Love Letters Jackie Gleason- Love Letters In The Sand Larry Newcombe- Essential Messengers MPS- Lost in Modulation
In der heutigen Episode widmen wir uns wieder den Quizfragen aus Arnos Vortrag. Wir befassen uns mit den faszinierenden Einflüssen der sozialen Umgebung auf unsere stimmlichen Verhaltensmuster. Du bekommst Antworten auf folgende Fragen:Wie prägt die soziale Umgebung langfristig unsere stimmlichen Ausdrucksweisen?Welche Möglichkeiten gibt es, durch gezieltes Training signifikante Veränderungen der Stimme herbeizuführen?In welchem Ausmaß beeinflusst die Stimme die Wahrnehmung von Führungskompetenz?Welche Stimmlage wird am häufigsten mit Introvertiertheit assoziiert?Wie hängen Introvertiertheit und gestisches Verhalten zusammen?Wie kann Schlafmangel die Modulation unserer Stimme beeinflussen?Welche Maßnahmen können helfen, die Stimme nach einer schlechten Nacht zu verbessern?Warum wird eine tiefe Stimme oft mit Leadership verbunden und welche Vorteile bringt das im beruflichen Kontext?Wie stark sind genetische Faktoren und Umweltbedingungen für die Entwicklung der Stimme verantwortlich?Welche Rolle spielen Muttersprache und Dialekt in der stimmlichen Artikulation?Was zeigen Studien im Vergleich zwischen hohen und tiefen Stimmen bezüglich ihrer Wahrnehmung als Führungspersonen?Wie wirkt sich die Körpergröße auf den beruflichen Erfolg aus?Wie prägen Kinder die Sprechweise ihrer Bezugspersonen und was bedeutet das für das spätere stimmliche Verhalten?Inwiefern können Menschen ihre Stimme durch Training bewusst modifizieren?Welche konkreten Übungen gibt es für die Atemführung, Stimmprojektion und Stimmresonanz im Stimmtraining?Was kann regelmäßiges Wassertrinken für unsere Stimme tun und warum ist es so wichtig?Wie hängen Electrolyte und Salzaufnahme mit der Stimmgesundheit zusammen, insbesondere für Sportler und Menschen mit speziellen Ernährungsgewohnheiten?Welche historischen Missverständnisse gab es in Bezug auf Salz und warum ist dessen richtige Dosierung wichtig für unsere stimmliche Performance?Inwiefern beeinflussen Alkohol und Schlafmangel die Stimmlage und was kann man dagegen tun?Hör rein in diese spannende Episode und finde Antworten auf all diese Fragen! Verpasse nicht die Möglichkeit, deine Meinung und Fragen mit uns zu teilen. Wir freuen uns auf deine Rückmeldungen und Kommentare auf Plattformen wie Spotify und Apple Podcast. Viel Spaß beim Zuhören! Euer "Stimme wirkt!"-Team . . . . . . . . . . . . . .Gesprächspartner von Arno Fischbacher ist auch in dieser Episode Andreas K. Giermaier von https://lernenderzukunft.com/Dein Voicecoach Arno Fischbacher begleitet Dich auf Deinem persönlichen Weg von Stimm-Besitzer zum Stimm-Benutzer!✅ Hast Du Fragen? Schreib an podcast@arno-fischbacher.com✅ Du willst mit mir persönlich sprechen? Gern: https://arno-fischbacher.com/espresso
Dannic - All Mine (Extended Mix) DONT BLINK - MODULATION Claw & Zane - Welcome To The Rave (Instrumental Extended Mix) Joachim Garraud & Friends - HWBBIHC The Chemical Brothers - Hey Boy Hey Girl (ARTBAT Remix) [Extended Mix] Quench - Dreams (Joachim Garraud Remix) Joachim Garraud & Friends - BHAWXRR Meetch - Feel It Marten Hørger - Don't Stop (Extended Mix) Joachim Garraud & Friends - MJYRSTS LUMBERJACK - Welcome To The Game (Extended Mix) DJ Yasmin & HΛNNΛH X - Clap Anthem (Extended Mix) Anti Up - Set Me Free HAUS OF PANDA & USE CAUTION - IN MY HAUS Violate_(Extended_Mix) Joachim G.- Proud Mosher Sebastian Mora - Anasthasia
Did you know that you can modify your rest periods to create more intense workouts without having to increase weight or reps? Did you know that "rest periods" also refers to the time between similar movements? Want to learn more specifics and fun ways to create more workout variety? Listen in!!!
En el episodio de hoy, describimos el modelo de competición interhemisférica, base de algunas técnicas de estimulación cerebral no invasiva y exponemos las críticas y modelos alternativos en la actualidad para explicar esa relación entre hemisferios cerebrales y la relación con la recuperación motora tras un ictus. 1. Di Pino, G., Pellegrino, G., Assenza, G., Capone, F., Ferreri, F., Formica, D., Ranieri, F., Tombini, M., Ziemann, U., Rothwell, J. C., & Di Lazzaro, V. (2014). Modulation of brain plasticity in stroke: a novel model for neurorehabilitation. Nature reviews. Neurology, 10(10), 597–608. https://doi.org/10.1038/nrneurol.2014.162 (https://pubmed.ncbi.nlm.nih.gov/25201238/). 2. Brancaccio, A., Tabarelli, D., & Belardinelli, P. (2022). A New Framework to Interpret Individual Inter-Hemispheric Compensatory Communication after Stroke. Journal of personalized medicine, 12(1), 59. https://doi.org/10.3390/jpm12010059 (https://pubmed.ncbi.nlm.nih.gov/35055374/). 3. Lee, H. S., Kim, D. H., Seo, H. G., Im, S., Yoo, Y. J., Kim, N. Y., Lee, J., Kim, D., Park, H. Y., Yoon, M. J., Kim, Y. S., Kim, H., & Chang, W. H. (2024). Efficacy of personalized rTMS to enhance upper limb function in subacute stroke patients: a protocol for a multi-center, randomized controlled study. Frontiers in neurology, 15, 1427142. https://doi.org/10.3389/fneur.2024.1427142 (https://pubmed.ncbi.nlm.nih.gov/39022726/). 4. Xu, J., Branscheidt, M., Schambra, H., Steiner, L., Widmer, M., Diedrichsen, J., Goldsmith, J., Lindquist, M., Kitago, T., Luft, A. R., Krakauer, J. W., Celnik, P. A., & SMARTS Study Group (2019). Rethinking interhemispheric imbalance as a target for stroke neurorehabilitation. Annals of neurology, 85(4), 502–513. https://doi.org/10.1002/ana.25452 (https://pubmed.ncbi.nlm.nih.gov/30805956/). 5. Murase, N., Duque, J., Mazzocchio, R., & Cohen, L. G. (2004). Influence of interhemispheric interactions on motor function in chronic stroke. Annals of neurology, 55(3), 400–409. https://doi.org/10.1002/ana.10848 (https://pubmed.ncbi.nlm.nih.gov/14991818/). 6. Ferbert, A., Priori, A., Rothwell, J. C., Day, B. L., Colebatch, J. G., & Marsden, C. D. (1992). Interhemispheric inhibition of the human motor cortex. The Journal of physiology, 453, 525–546. https://doi.org/10.1113/jphysiol.1992.sp019243 (https://pubmed.ncbi.nlm.nih.gov/1464843/).
Dr. Rosenblum reviews the benefits of Scrambler Therapy for CRPS and Neuropathic Pain State. What is Scrambler Therapy? Efficacy of Scrambler Therapy for Neuropathic Pain Mechanism of action of Scrambler Therapy Regenerative Pain Management Course PainExam Board Prep NRAP Academy Private Tutorials for Ultrasound Guidance and Regenerative Medicine ST was introduced as a chronic pain relief method in 2003. That same year, Giuseppe Marineo published findings from a small clinical trial involving 11 terminal cancer patients suffering from drug-resistant chronic visceral pain, with all participants showing positive responses and significant reductions in pain scores. In a subsequent trial involving 226 patients with neuropathic pain, 80% reported a 50% reduction in pain. Since then, numerous case reports and studies have documented the use of ST for various pain types. Evidence from these reports suggests that ST is effective for managing both acute and chronic pain from different causes. For instance, a child with acute mixed pain, resistant to pharmacological treatment, experienced significant relief after four ST sessions, with pain levels dropping from 5/10 to 0/10. Additionally, a 52-year-old woman with burning pain from her foot to knee, stemming from a right medullary acute hemorrhage and suffering for 12 years, reported immediate relief after ST. Her pain score decreased from 9/10 to 3/10 on the first day, and to 0/10 by the second day, remaining below 1 on the Visual Analog Scale (VAS) throughout the 10-day treatment period. In terms of chronic pain, literature includes a case where a patient with shoulder joint pain and limited range of motion saw significant pain reduction and increased mobility after 10 sessions of ST. ST has shown considerable promise in treating severe pain conditions that are typically difficult to manage, such as complex regional pain syndrome and pain related to HIV. Despite the encouraging results from these case studies, higher-quality evidence is necessary to establish the efficacy of ST, which could be obtained through extensive clinical trials, particularly focusing on chronic pain. Besides the aforementioned studies by Marineo and Sabato et al, additional trials have indicated that ST is an effective treatment for various chronic pain conditions, including low back pain, postherpetic pain, and neuropathic pain. For instance, a prospective study on chronic low back pain patients showed a significant decrease in VAS scores from 8.12 to 3.63 after six treatment days. Another trial involving 10 patients with postherpetic pain reported a drop in the average Numeric Rating Scale (NRS-11) score from 7.64 to 1.46 at baseline and 0.42 to 0.89 after one month, with benefits persisting at two and three months. ST has also demonstrated significant potential in treating neuropathic pain. In a prospective study of 45 patients with neuropathic pain lasting over three months, 28 experienced a decrease in Douleur Neuropathique en 4 questions (DN4) pain scores, with four patients stopping treatment early due to complete pain resolution. The mean baseline DN4 score dropped from 5.67 to 2.82 by the end of treatment. A pilot randomized trial involving 52 patients found that 21 out of 26 in the intervention group achieved complete pain relief. While the findings from these studies, along with others that have been systematically analyzed, suggest strong evidence for the efficacy of ST, a definitive conclusion regarding its effectiveness has not yet been reached. A systematic review by Majithia et al concluded that while studies generally indicate ST results in pain reduction with lasting benefits, there are still gaps in the evidence. This article aims to evaluate the research needs surrounding ST for cancer pain management. While Majithia et al focused on chronic pain across various conditions and noted specific evidence limitations, this study will concentrate on the effectiveness of ST for cancer-related pain. The objective is to identify gaps in the existing literature and provide recommendations for future research through a systematic review. We will specifically analyze the types and levels of evidence supporting the use of ST in managing cancer pain and determine what studies are necessary to enhance the evidence base. References Majithia, N., Smith, T.J., Coyne, P.J. et al. Scrambler Therapy for the management of chronic pain. Support Care Cancer 24, 2807–2814 (2016). https://doi.org/10.1007/s00520-016-3177-3 Mohamed, Mohamed S. I.1; Alkahlout, Lama1; Elgamal, Salma1; Mohiuddin, Amna1; Al-sayed, Talal1; Al-Marri, Hamad1; Zahid, Fatima1; Martínez-Magallanes, Daniela2; Fregni, Felipe2; Doi, Suhail A. R.1; Abdallah, Abdallah M.3; Musa, Omran A.H.1,4; Khan, Muhammad Naseem1; Babu, Giridhara R.1,*. Efficacy of scrambler therapy in chronic neuropathic pain: pairwise and dose-response meta-analysis. Brain Network and Modulation 3(3):p 63-70, Jul–Sep 2024. | DOI: 10.4103/BNM.BNM_20_24 Kashyap, Komal, and Sushma Bhatnagar. "Evidence for the efficacy of scrambler therapy for cancer pain: a systematic review." Pain Physician 23.4 (2020): 349.
Dr. Rosenblum reviews the benefits of Scrambler Therapy for CRPS and Neuropathic Pain State. What is Scrambler Therapy? Efficacy of Scrambler Therapy for Neuropathic Pain Mechanism of action of Scrambler Therapy Regenerative Pain Management Course PainExam Board Prep NRAP Academy Private Tutorials for Ultrasound Guidance and Regenerative Medicine ST was introduced as a chronic pain relief method in 2003. That same year, Giuseppe Marineo published findings from a small clinical trial involving 11 terminal cancer patients suffering from drug-resistant chronic visceral pain, with all participants showing positive responses and significant reductions in pain scores. In a subsequent trial involving 226 patients with neuropathic pain, 80% reported a 50% reduction in pain. Since then, numerous case reports and studies have documented the use of ST for various pain types. Evidence from these reports suggests that ST is effective for managing both acute and chronic pain from different causes. For instance, a child with acute mixed pain, resistant to pharmacological treatment, experienced significant relief after four ST sessions, with pain levels dropping from 5/10 to 0/10. Additionally, a 52-year-old woman with burning pain from her foot to knee, stemming from a right medullary acute hemorrhage and suffering for 12 years, reported immediate relief after ST. Her pain score decreased from 9/10 to 3/10 on the first day, and to 0/10 by the second day, remaining below 1 on the Visual Analog Scale (VAS) throughout the 10-day treatment period. In terms of chronic pain, literature includes a case where a patient with shoulder joint pain and limited range of motion saw significant pain reduction and increased mobility after 10 sessions of ST. ST has shown considerable promise in treating severe pain conditions that are typically difficult to manage, such as complex regional pain syndrome and pain related to HIV. Despite the encouraging results from these case studies, higher-quality evidence is necessary to establish the efficacy of ST, which could be obtained through extensive clinical trials, particularly focusing on chronic pain. Besides the aforementioned studies by Marineo and Sabato et al, additional trials have indicated that ST is an effective treatment for various chronic pain conditions, including low back pain, postherpetic pain, and neuropathic pain. For instance, a prospective study on chronic low back pain patients showed a significant decrease in VAS scores from 8.12 to 3.63 after six treatment days. Another trial involving 10 patients with postherpetic pain reported a drop in the average Numeric Rating Scale (NRS-11) score from 7.64 to 1.46 at baseline and 0.42 to 0.89 after one month, with benefits persisting at two and three months. ST has also demonstrated significant potential in treating neuropathic pain. In a prospective study of 45 patients with neuropathic pain lasting over three months, 28 experienced a decrease in Douleur Neuropathique en 4 questions (DN4) pain scores, with four patients stopping treatment early due to complete pain resolution. The mean baseline DN4 score dropped from 5.67 to 2.82 by the end of treatment. A pilot randomized trial involving 52 patients found that 21 out of 26 in the intervention group achieved complete pain relief. While the findings from these studies, along with others that have been systematically analyzed, suggest strong evidence for the efficacy of ST, a definitive conclusion regarding its effectiveness has not yet been reached. A systematic review by Majithia et al concluded that while studies generally indicate ST results in pain reduction with lasting benefits, there are still gaps in the evidence. This article aims to evaluate the research needs surrounding ST for cancer pain management. While Majithia et al focused on chronic pain across various conditions and noted specific evidence limitations, this study will concentrate on the effectiveness of ST for cancer-related pain. The objective is to identify gaps in the existing literature and provide recommendations for future research through a systematic review. We will specifically analyze the types and levels of evidence supporting the use of ST in managing cancer pain and determine what studies are necessary to enhance the evidence base. References Majithia, N., Smith, T.J., Coyne, P.J. et al. Scrambler Therapy for the management of chronic pain. Support Care Cancer 24, 2807–2814 (2016). https://doi.org/10.1007/s00520-016-3177-3 Mohamed, Mohamed S. I.1; Alkahlout, Lama1; Elgamal, Salma1; Mohiuddin, Amna1; Al-sayed, Talal1; Al-Marri, Hamad1; Zahid, Fatima1; Martínez-Magallanes, Daniela2; Fregni, Felipe2; Doi, Suhail A. R.1; Abdallah, Abdallah M.3; Musa, Omran A.H.1,4; Khan, Muhammad Naseem1; Babu, Giridhara R.1,*. Efficacy of scrambler therapy in chronic neuropathic pain: pairwise and dose-response meta-analysis. Brain Network and Modulation 3(3):p 63-70, Jul–Sep 2024. | DOI: 10.4103/BNM.BNM_20_24 Kashyap, Komal, and Sushma Bhatnagar. "Evidence for the efficacy of scrambler therapy for cancer pain: a systematic review." Pain Physician 23.4 (2020): 349.
Download & Stream: https://moonharbour.lnk.to/MHD237 German producer Chris Di Perri returns to Moon Harbour for the second time in 2024 with his superb Space Modulation EP. Chris Di Perri once again proves why he is one of Tech House's most prominent artists with this arresting new EP.
In this episode, Megan and Frank examine hypnosis. What evidence is there that hypnosis is a real phenomenon, and why does hypnosis have a dubious reputation? Does hypnosis alleviate pain, or just mask it? What is the nature of hypnotic consciousness? And does hypnosis prove there's no true self? Thinkers discussed include: William James, Ernest and Josephine Hilgard, Derek Parfit, Sigmund Freud, and Tim Bayne.-----------------------Hosts' Websites:Megan J Fritts (google.com)Frank J. Cabrera (google.com)Email: philosophyonthefringes@gmail.com-----------------------Bibliography:Uncovering the new science of clinical hypnosisThe Morpheus Clinic for HypnosisHypnobirthing - Google BooksHypnosis and Conscious States: The Cognitive Neuroscience PerspectiveHypnosis to quit smoking: What to knowNeural functional correlates of hypnosis and hypnoanalgesia: Role of the cingulate cortexHypnotic Suggestion and the Modulation of Stroop InterferenceHypnosis in the Relief of PainMary Haight, Hypnosis and the Philosophy of MindHypnotism and Mesmerism | VoxHypnosis in History - American Hypnosis AssociationHidden observer - Oxford ReferenceHidden Observer APA DictionaryThe split brain: A tale of two halves | NatureDerek Parfit. Here's why he mattered. | VoxTim Bayne, Hypnosis and the unity of consciousnessTim Bayne - The Unity of Consciousness | Oxford Academic (oup.com)Bilingual “I Hear a Pickle/ Oigo Un Pepinello” (kidizen.com)-----------------------Cover Artwork by Logan Fritts-------------------------Music from #Uppbeat (free for Creators!):https://uppbeat.io/t/simon-folwar/neon-signsLicense code: DC5U47IEPMLOLTFG
Today, we're talking about something that might surprise you—we're going to talk about Botox. If you're asking, “Why are we discussing Botox on a podcast focused on mental health?” Another centerpiece to this podcast is talking about ways to support, heal and regulation your nervous systems, in that it's important to consider how everything we do—including something as common as a Botox—could play a role. Today we'll talk about both the cosmetic & medical uses of Botox as we talk through it's benefits and it's potential impact on your nervous system, brain, and emotional regulation (potentially of you and your kids). Hit play to learn more!Here's the 3 takeaways:Botox is a neurotoxin. It is used both medically & cosmetically. Most of the research show's it's more safe than not but that doesn't mean there aren't risks and side effects. Do you feel aligned with how or why you choose Botox? Does it improve that quality of your life in a way that outweighs potential costs?Potential costs of botox include muscle atrophy, changes in brain activity, and emotional regulation - with potential implication for both you and your children's emotional literacy.Long-term effects of Botox are not fully understood.Sources mentioned:Stark, S., Stark, C., Wong, B. et al. Modulation of amygdala activity for emotional faces due to botulinum toxin type A injections that prevent frowning. Sci Rep 13, 3333 (2023). Davis JI, Senghas A, Brandt F, Ochsner KN. The effects of BOTOX injections on emotional experience. Emotion. 2010 Jun;10(3):433-40. doi: 10.1037/a0018690. PMID: 20515231; PMCID: PMC2880828.Weise D, Weise CM, Naumann M. Central Effects of Botulinum Neurotoxin-Evidence from Human Studies. Toxins (Basel). 2019 Jan 6;11(1):21. doi: 10.3390/toxins11010021. PMID: 30621330; PMCID: PMC6356587.BBC Article: Are there long-term health risks to using Botox?Looking for more personalized support?Book a FREE consultation for RESTORE, our 1:1 anxiety & depression coaching program.Join me inside RISE, a mental health membership and nervous system healing space.Order my book, Healing Through the Vagus Nerve today!Want me to talk about something specific on the podcast? Let me know HERE.Website: https://www.riseaswe.com/podcastEmail: amanda@riseaswe.comInstagram: https://www.instagram.com/amandaontherise/TikTok: https://www.tiktok.com/@amandaontherise
Welcome back to Season 12 of the Neuroscience Meets Social and Emotional Learning podcast! In episode #343, host Andrea Samadi interviews Dr. Sui Wong, a renowned neurologist and neuro-ophthalmologist based in London, UK. With over 110 peer-reviewed publications and extensive research in mindfulness-based cognitive therapy, Dr. Wong shares her holistic approach to improving brain health and patient outcomes. Discover the science behind visual snow syndrome, the impact of lifestyle-specific interventions, and the connection between eye health and neurological disorders like Alzheimer's and Parkinson's. Dr. Wong also delves into the importance of mindfulness, nutrition, sleep, and a balanced lifestyle in enhancing overall well-being. Join us for an insightful conversation that bridges neuroscience with practical strategies for everyday life. Don't miss this episode filled with valuable insights and actionable tips to help you thrive. Welcome, Dr. Sui Wong! Watch our interview on YouTube here https://youtu.be/GwR82IYJTbE EPISODE #343 with Dr. Sui Wong on “Unlocking Brain Health: Insights from a Leading Neuro-Ophlamologist we will cover: ✔ Dr. Sui Wong's career path in medicine, that led her to write 4 books to help her patients (and the world) improve their brain health. ✔ How understanding our eye health can help us to prevent neurological disorders (like Alzheimer's Disease) in the future. ✔ What we should all understand about our eye health for improved health and longevity. ✔ What common neuro-ophthalmology cases she sees. ✔ Why did she introduce Mindfulness into a study on Visual Snow Syndrome? ✔ What would Dr. Wong add to our list of Top 6 Health Staples? ✔ How to learn from Dr. Wong, and find her books. On today's episode #343 we meet with Dr. Sui H. Wong, a Neurologist and Neuro-Ophthalmologist based in London, United Kingdom. In addition to her clinical work as a medical doctor and physician, Dr. Wong is an active neuroscience researcher, who translates pertinent and clinically relevant questions into research, to improve person-centred patient outcomes. Additionally, she has the qualifications and experience to consider a broader spectrum of lifestyle-specific interventions. Dr Wong's holistic approach in empowering patients has been recognized with many awards, and this is just the beginning for her. When I was introduced to Dr. Wong, an active neuroscience researcher with a mission of translating important clinically relevant questions into research for improved person-centred patient outcomes, I knew I had to speak with her. She is a widely published author and researcher with over 110+ peer-reviewed publications in medical journals, chapters and conference abstracts, to date. I looked at the articles Dr. Wong has published, and one caught my eye. She's done extensive research that you can find in Ophthalmology Journals, like a recent article that I'm going to paraphrase, but it was called Visual Snow Syndrome (which is a neurological condition where individuals see persistent flickering white, black, transparent or colored dots across the whole visual field) After Mindfulness-Based Cognitive Therapy.[i] We have spent some time on this podcast walking through Pubmed.gov, and if you go there, and put Mindfulness into the search bar, you will come up with over 30,000 results. Let's meet Dr. Sui Wong, and see what we can learn from her decades of research and her thoughts on what lifestyle-specific interventions she recommends. Welcome Dr. Wong, thank you for coming on the podcast today, and meeting me, all the way from the UK (where I was born)(Worthing, Sussex). Welcome. Q1: Can you give us an overview of why you chose this path and ended up in Neuro-Ophthalmology with an explanation of what you do with your work? Q2: How can understanding our eye health help us to prevent neurological disorders in the future? We've covered Alzheimer's Prevention strategies and I wonder what you would with the importance of our brain health? Q3: I listened to a recent podcast you did on Neuro Podcases and while I don't have a case for you, I'll tell you I had a scary eye experience years ago? It turned out to be an ocular migraine, but I seriously thought I was going blind. Before I spoke to my doctor, I had no idea what this was, and that it was nothing to worry about. What do you recommend we ALL learn and understand about our eye health for improved health and longevity? Q3B: Is there a connection between migraines in our head, and our gut-brain axis? Q4: What are some common neuro-ophthalmology cases you see? Q5: I looked at your research and one of your publications drew my attention. It was the Visual Snow Syndrome study that improved with Mindfulness-Based Cognitive Therapy. Since we talk about Mindfulness often on this podcast, can you share what this study revealed? What can we all take away from the power of Mindfulness? Q6: What advice would you give us outside of this list that we've created from all our interviews, of the TOP 6 health staples to boost our physical, and mental heath, helping us to age gracefully, and how much of our health do you think has to do our brain health? Q7: For people to reach you, what is the best way? What services do you provide? Q8: Anything I have missed? Dr. Wong, I want to thank you for your time, meeting with me today, and helping us to all make the connection with our brain health, and longevity. RESOURCES AND CONNECT WITH DR. SUI WONG Thursday Tips-Bitesize brain health tips to thrive: bit.ly/drwongbrainhealth Website for Dr. Wong's books: https://www.drsuiwongmd.com/books Instagram: https://www.instagram.com/drsuiwong.neurologist/ LinkedIn: https://www.linkedin.com/in/dr-sui-wong-neurologist/ Mindfulness for Brain Health (in paperback/ hardcover/ Kindle/ audiobook) https://books2read.com/u/4XNXAg Break Free from Migraines Naturally (in paperback/ hardcover/ Kindle/ audiobook) https://books2read.com/u/bwgG5Z Sleep Better to Thrive (in paperback/ Kindle/ audiobook) books2read.com/u/mv0XQ2 Quit Ultra-Processed Foods Now (in paperback/ Kindle/ audiobook) https://books2read.com/u/m27M21 Email office@neuroeye.co.uk REFERENCES: [i] Visual Snow Syndrome Improves with Modulation of Resting-State Functional MRI Connectivity After Mindfulness-Based Cognitive Therapy published by Sui H Wong, et al, March 2024 https://pubmed.ncbi.nlm.nih.gov/37967050/
In this episode, we explored ozone insufflation, a lesser-known therapy that's gaining attention for its potential benefits in supporting the health of breast cancer survivors. Ozone, a molecule made up of three oxygen atoms, is commonly known for its role in the atmosphere, but in a medical setting, it can be used to help our bodies in various ways. I'll break down how ozone therapy works, and share some fascinating research findings with you. If you're interested in a non-toxic therapy that helps with pain relief and tissue repair, might reduce the harmful side effects of chemotherapy, and can support our immune system. This episode is for you. While ozone insufflation shows promise, it's important to remember that it should be used under professional guidance to ensure it's right for your individual needs. Overall, this therapy could be an interesting addition to your wellness toolkit, helping you feel more supported on your path to recovery. Every very step we take toward supporting our health is a step in the right direction. Referred to in this episode: Better Than Before Breast Cancer™ Life Coaching Membership Ozone therapy in musculoskeletal medicine: a comprehensive review Modulation of Oxidative Stress by Ozone Therapy in the Prevention and Treatment of Chemotherapy-Induced Toxicity: Review and Prospects Systemic Ozone Therapy by Rectal Insufflation for Immunoglobulin A Deficiency MATC trained Doctors Follow me on Social Media: Facebook Instagram Pinterest YouTube
Eric Edmeades explains how voice modulation is key for engaging audiences. He advises becoming "trilingual" in communication by mastering auditory, visual, and kinesthetic voice modes to connect with different listener preferences.
Wellness + Wisdom | Episode 658 Are your probiotics helping you heal your gut or are you just wasting your money? Tina Anderson, Co-Founder of Just Thrive, joins Josh Trent on the Wellness + Wisdom Podcast, episode 658, to explain why most probiotics are not real probiotics, how spore-based probiotics heal the gut microbiome, why gut health is essential for your mental health and brain function, and what the healing protocol for the gut consists of. "99.99% of probiotics die by the time they get to the intestines. If a probiotic needs to be refrigerated in order to stay alive, it wouldn't even survive on the store shelf which means it could never survive your body temperature. Spore-based probiotic has this endospore shell around itself which allows it to be a very hardy organism and survive the journey from the mouth through the gastric system into the intestines." - Tina Anderson 20% Off Just Thrive Probiotics There are hundreds of brands of probiotics on the market, but as you've probably already discovered, they are not all equal. Just Thrive® is the first 100% spore-forming probiotic and antioxidant supplement that arrives 100% alive to your intestines that's available in the retail market. Just Thrive® contains a patented strain called Bacillus Indicus HU36® – bacillus strains are abundant environmental organisms that are a normal part of the human microflora. This strain, Bacillus Indicus HU36®, produces antioxidants/ carotenoids (the nutrients that give red peppers and tomatoes their color) in your intestines where they can be best absorbed by the body, making it one of the most absorbable forms of antioxidants on the market. These spores have been successfully used to enhance digestive health for more than 50 years! 20% off with code "JOSH" In This Episode, Tina Anderson Uncovers: [01:30] Gut Imbalances Are The Cause of Disease Tina Anderson Just Thrive - 20% off with the code JOSH 360 Tina Anderson | Gut Health: The New Probiotic Strain That Changes Everything Why people have been taking more control over their health since 2020. How every disease is related to gut imbalances. [05:30] Pharmaceuticals: A Bandage for Symptoms Why Tina shifted from litigation to the pharmaceutical industry. How doctors are encouraged to prescribe medications even if the patients don't need them. Why we always need to identify the root cause of an illness. [08:50] Spor-Based Probiotics How Tina never compromised her family and business but compromised her own needs. Why people buy supplements. What motivated Tina and her husband to create the first spore-based probiotics. Why probiotics don't need to be refrigerated. Most probiotic strains die by the time they reach the stomach. [16:20] Most Probiotics Are Not Real Probiotics What helped them decide if they're going to start Just Thrive. Why probiotics need to be able to stay alive in the intestines. How we used to get spores from the soil. Why the two most common probiotic strains are not what the body needs. [22:05] Return to Nature Why doctors in Japan prescribe time in nature to their patients. How spore probiotics helped an autistic child to improve his life. Reactive and responsive health models. Modulation of Gut Microbiota and Immune System by Probiotics, Pre-biotics, and Post-biotics [27:35] Gut-Brain Axis The brain sends signals to the gut and the gut sends signals to the brain. 90% of serotonin is produced in the gut. How stress sends information to the stomach. Why allergies are more common now than ever before. How reducing bacteria in the environment causes harm. [31:50] The Healing Protocol for The Gut How our food is being poisoned. What we can do to protect and heal our gut. How antibiotics lower the immune system function. Why meditation is an important factor in healing the gut microbiome. How exposure to new types of foods is good for gut health. [36:55] What Causes Chronic Disease Why so many people struggle with leaky gut. How spore-based probiotics remove LPS toxins from the gut. An imbalanced gut microbiome can lead to autoimmune disease. Why inflammation is the main cause of chronic disease. [41:50] Why Children Are Sick Why we shouldn't always listen to the doctor. How Big Pharma education is misleading people. Why yogurt is not always good for gut health. There is an epidemic of children's disease. How the mother influences her child's microbiome during pregnancy and birth. 638 Tiny Health: Healing Family Gut Dysbiosis + The Missing Link Between Child Chronic Condition Crisis (Cheryl Sew Hoy) [49:15] New Perspective on Health How nature provides healing. Why a doctor in Serbia prescribed a girl to go to the sea to heal. The importance of applying common sense to our health. Why we need to search for new perspectives if we want to heal. [55:50] Probiotic Myths Why the gut is constantly under attack. The side effects of Just Thrive are better mood and sleep. Why the amount of probiotic strains doesn't mean the probiotics are better. The importance of diversity in the gut microbiome. Leave Wellness + Wisdom a Review on Apple Podcasts
Did you know that one simple change in your kitchen could transform your health? In today's episode, Miles Hassell, MD, explores the extensive health benefits of extra virgin olive oil (EVOO). Drawing on three lines of evidence, he makes a compelling case for making EVOO your primary kitchen fat. A few takeaways from Miles Hassell, MD: Studies have shown that EVOO supports gut health. A healthy gut can contribute to improved digestion, a stronger immune system, and even better mental health. Regular consumption of EVOO has been associated with a lower incidence of dementia. This connection underscores the importance of incorporating EVOO into your diet as part of a proactive approach to brain health. Research indicates that higher consumption of olive oil is linked to a lower incidence of certain cancers. The powerful antioxidant and anti-inflammatory properties of EVOO play a significant role in reducing cancer risk. One of the most well-documented benefits of EVOO is its ability to lower the risk of heart disease. Unlike other vegetable oils, EVOO has been consistently shown to promote cardiovascular health. Miles Hassell, MD emphasizes that EVOO is not just a cooking ingredient but a therapeutic tool. Its unique composition of monounsaturated fats, antioxidants, and anti-inflammatory compounds makes it a powerhouse for health promotion. While other vegetable oils lack the same level of evidence for health benefits, EVOO stands out for its protective effects. When compared to other oils, EVOO consistently comes out on top. Making the switch to EVOO can be a simple yet powerful change to improve your overall health. So next time you're cooking, reach for the EVOO and enjoy both its flavor and its multitude of health benefits. Join the cause! Support the podcast and be a champion of a future episode by donating here: https://greatmed.org/donate/ For more information and references head to: https://greatmed.org Purchase Good Food Great Medicine Twitter (X): https://x.com/greatmedorg Instagram: @mileshassellmd Facebook: https://www.facebook.com/people/GreatMedorg/61554645308577/ Substack: https://substack.com/@greatmed YouTube: https://www.youtube.com/@greatmedicine email: info@greatmed.org References for Today's Episode: Markellos C, Ourailidou ME, Gavriatopoulou M, Halvatsiotis P, Sergentanis TN, Psaltopoulou T. Olive oil intake and cancer risk: A systematic review and meta-analysis. PLoS One. 2022 Jan 11;17(1):e0261649. doi: 10.1371/journal.pone.0261649. PMID: 35015763; PMCID: PMC8751986. Millman JF, Okamoto S, Teruya T, Uema T, Ikematsu S, Shimabukuro M, Masuzaki H. Extra-virgin olive oil and the gut-brain axis: influence on gut microbiota, mucosal immunity, and cardiometabolic and cognitive health. Nutr Rev. 2021 Nov 10;79(12):1362-1374. doi: 10.1093/nutrit/nuaa148. PMID: 33576418; PMCID: PMC8581649. Guasch-Ferré M, Hruby A, Salas-Salvadó J, Martínez-González MA, Sun Q, Willett WC, Hu FB. Olive oil consumption and risk of type 2 diabetes in US women. Am J Clin Nutr. 2015 Aug;102(2):479-86. doi: 10.3945/ajcn.115.112029. Epub 2015 Jul 8. PMID: 26156740; PMCID: PMC4515873 Valls-Pedret C, Lamuela-Raventós RM, Medina-Remón A, Quintana M, Corella D, Pintó X, Martínez-González MÁ, Estruch R, Ros E. Polyphenol-rich foods in the Mediterranean diet are associated with better cognitive function in elderly subjects at high cardiovascular risk. J Alzheimers Dis. 2012;29(4):773-82. doi: 10.3233/JAD-2012-111799. PMID: 22349682. Moreno-Luna R, Muñoz-Hernandez R, Miranda ML, Costa AF, Jimenez-Jimenez L, Vallejo-Vaz AJ, Muriana FJ, Villar J, Stiefel P. Olive oil polyphenols decrease blood pressure and improve endothelial function in young women with mild hypertension. Am J Hypertens. 2012 Dec;25(12):1299-304. doi: 10.1038/ajh.2012.128. Epub 2012 Aug 23. PMID: 22914255. Cougnard-Grégoire A, Merle BM, Korobelnik JF, Rougier MB, Delyfer MN, Le Goff M, Samieri C, Dartigues JF, Delcourt C. Olive Oil Consumption and Age-Related Macular Degeneration: The Alienor Study. PLoS One. 2016 Jul 28;11(7):e0160240. doi: 10.1371/journal.pone.0160240. PMID: 27467382; PMCID: PMC4965131. Kien CL, Bunn JY, Tompkins CL, Dumas JA, Crain KI, Ebenstein DB, Koves TR, Muoio DM. Substituting dietary monounsaturated fat for saturated fat is associated with increased daily physical activity and resting energy expenditure and with changes in mood. Am J Clin Nutr. 2013 Apr;97(4):689-97. doi: 10.3945/ajcn.112.051730. Epub 2013 Feb 27. Erratum in: Am J Clin Nutr. 2013 Aug;98(2):511. PMID: 23446891; PMCID: PMC3607650. Guasch-Ferré M, Liu G, Li Y, Sampson L, Manson JE, Salas-Salvadó J, Martínez-González MA, Stampfer MJ, Willett WC, Sun Q, Hu FB. Olive Oil Consumption and Cardiovascular Risk in U.S. Adults. J Am Coll Cardiol. 2020 Apr 21;75(15):1729-1739. doi: 10.1016/j.jacc.2020.02.036. Epub 2020 Mar 5. PMID: 32147453; PMCID: PMC7233327. Ferrara LA, Raimondi AS, d'Episcopo L, Guida L, Dello Russo A, Marotta T. Olive oil and reduced need for antihypertensive medications. Arch Intern Med. 2000 Mar 27;160(6):837-42. doi: 10.1001/archinte.160.6.837. PMID: 10737284. Priore P, Cavallo A, Gnoni A, Damiano F, Gnoni GV, Siculella L. Modulation of hepatic lipid metabolism by olive oil and its phenols in nonalcoholic fatty liver disease. IUBMB Life. 2015 Jan;67(1):9-17. doi: 10.1002/iub.1340. Epub 2015 Jan 28. PMID: 25631376. Gutiérrez-Repiso C, Soriguer F, Rojo-Martínez G, García-Fuentes E, Valdés S, Goday A, Calle-Pascual A, López-Alba A, Castell C, Menéndez E, Bordiú E, Delgado E, Ortega E, Pascual-Manich G, Urrutia I, Mora-Peces I, Vendrell J, Vázquez JA, Franch J, Girbés J, Castaño L, Serrano-Ríos M, Martínez-Larrad MT, Catalá M, Carmena R, Gomis R, Casamitjana R, Gaztambide S. Variable patterns of obesity and cardiometabolic phenotypes and their association with lifestyle factors in the Di@bet.es study. Nutr Metab Cardiovasc Dis. 2014 Sep;24(9):947-55. doi: 10.1016/j.numecd.2014.04.019. Epub 2014 Jun 9. PMID: 24984822. Ramsden CE, Zamora D, Leelarthaepin B, Majchrzak-Hong SF, Faurot KR, Suchindran CM, Ringel A, Davis JM, Hibbeln JR. Use of dietary linoleic acid for secondary prevention of coronary heart disease and death: evaluation of recovered data from the Sydney Diet Heart Study and updated meta-analysis. BMJ. 2013 Feb 4;346:e8707. doi: 10.1136/bmj.e8707. Erratum in: BMJ. 2013;346:f903. PMID: 23386268; PMCID: Juul F, Vaidean G, Lin Y, Deierlein AL, Parekh N. Ultra-Processed Foods and Incident Cardiovascular Disease in the Framingham Offspring Study. J Am Coll Cardiol. 2021 Mar 30;77(12):1520-1531. doi: 10.1016/j.jacc.2021.01.047. PMID: 33766258. Schnabel L, Kesse-Guyot E, Allès B, Touvier M, Srour B, Hercberg S, Buscail C, Julia C. Association Between Ultraprocessed Food Consumption and Risk of Mortality Among Middle-aged Adults in France. JAMA Intern Med. 2019 Apr 1;179(4):490-498. doi: 10.1001/jamainternmed.2018.7289. PMID: 30742202; PMCID: PMC6450295. Lane MM, Gamage E, Du S, Ashtree DN, McGuinness AJ, Gauci S, Baker P, Lawrence M, Rebholz CM, Srour B, Touvier M, Jacka FN, O'Neil A, Segasby T, Marx W. Ultra-processed food exposure and adverse health outcomes: umbrella review of epidemiological meta-analyses. BMJ. 2024 Feb 28;384:e077310. doi: 10.1136/bmj-2023-077310. PMID: 38418082; PMCID: PMC10899807. Alonso-Pedrero L, Ojeda-Rodríguez A, Martínez-González MA, Zalba G, Bes-Rastrollo M, Marti A. Ultra-processed food consumption and the risk of short telomeres in an elderly population of the Seguimiento Universidad de Navarra (SUN) Project. Am J Clin Nutr. 2020 Jun 1;111(6):1259-1266. doi: 10.1093/ajcn/nqaa075. PMID: 32330232. Taneri PE, Wehrli F, Roa-Díaz ZM, Itodo OA, Salvador D, Raeisi-Dehkordi H, Bally L, Minder B, Kiefte-de Jong JC, Laine JE, Bano A, Glisic M, Muka T. Association Between Ultra-Processed Food Intake and All-Cause Mortality: A Systematic Review and Meta-Analysis. Am J Epidemiol. 2022 Jun 27;191(7):1323-1335. doi: 10.1093/aje/kwac039. PMID: 35231930.
Studies show that obese individuals have more Firmicutes and fewer Bacteroidetes in their gut bacteria compared to those who are not overweight. Research suggests that consuming apple cider vinegar (ACV) can help improve this ratio. Listen in this week as Dee explains ACV's impact on the gut microbiome and its role in weight loss.Link to Dee's Apple Cider Vinaigrette recipe: https://processedfreeamerica.org/dees-olive-oil-apple-cider-vinaigrette/References:Bouderbala, H., Dib, W., Kheroua, O., Saidi, D., & Kaddouri, H. (2019). Modulation of the intestinal microbiota by apple cider vinegar in rats subjected to cafeteria diet. Archives of Cardiovascular Diseases Supplements,11(3), e373-e374.https://doi.org/10.1016/j.acvdsp.2019.05.102Davis C. D. (2016). The gut microbiome and its role in obesity. Nutrition Today, 51(4), 167-174. https://doi.org/10.1097/NT.0000000000000167
Welcome to "Podcast Mastery Minute: Quick Wins for Podcast Creators," hosted by Brian In this episode, we focus on the importance of voice modulation and delivery in podcasting. Your voice is your most potent tool, and mastering its modulation can significantly enhance your podcast's impact.Key Points Discussed:Voice Modulation TechniquesVarying Pitch: Use different pitch levels to convey various emotions. Raise your pitch when expressing excitement and lower it for serious topics.Adjusting Pace: Speed up your speech to convey urgency or slow it down for emphasis on critical points.Changing Volume: Increase your volume to grab attention and decrease it to draw listeners in closer.Practicing Clear and Confident SpeechTechniques for clear articulation and confident delivery.The impact of a well-modulated voice on listener engagement and retention.Actionable StrategiesExercises and practices to improve your voice modulation skills.Practical tips for implementing these techniques in your podcast episodes.Importance of Consistent PracticeDeveloping a routine to practice voice modulation.Using feedback to continuously improve your delivery.Visit us at https://www.accountables.network
Download The Peptide Cheat Sheet: https://peptidecheatsheet.carrd.co/
Paradise (Extended Mix) - Mark Lower feat. Alexandra Prince The Boy is Mine (Division 4 Remix) - Ariana Grande The Best Things in Life Are Free (Dr Packer Extended Remix) - Janet Jackson & Luther Vandross Canned Heat (Dr Packer Extended Mix) - Jamiroquai These Walls (Extended Mix) - Dua Lipa Self Control (Extended Mix) - Jackers Revenge & Lissat Be With You (Original Mix) - Hugh Heffner Stumblin' In (Division 4 Remix) - Cyril Best of My Love (Extended Mix) - Revival & Imaani I Got Nothing (Ferreck Dawn Extended Mix) - Ferreck Dawn & Medusa feat. Clementine Douglas Soak Up the Sun (Rafael M Sunkissed Mix) - Division 4 Everybody Have Fun Tonight 2024 (Eric Kupper Remix) - Wang Chung Bamboogie (Get Down Tonight) [Extended Mix] - Bamboo & 5&Dime
One of the things that helps us obey is knowing from whom the command comes, how much authority they have, and how much doing what they ask will matter. If the command comes from a coworker - it will not have the same impact as if it had come directly from the boss. Well, we have commands that have come directly from the Lord. The Thessalonians believers understood that the word that the Apostle gave them was in truth - the word of God. And they responded accordingly. To support this ministry financially, visit: https://www.oneplace.com/donate/1425/29
Everyone comes into the world as a baby but we mature - some faster than others!. The same is true spiritually. And too many in the Church have not matured. As we'll hear today, part of the problem is our low view of the Bible - that's why there is such a disinterest in the things of God. But the bible is the very word of God - when the bible speaks, God speaks. And if the bible is the very word of God then how should we respond? We should receive it and welcome it - just like the Thessalonians did. To support this ministry financially, visit: https://www.oneplace.com/donate/1425/29
Parkinson's disease is a neurodegenerative disorder characterized by uncontrollable movements, stiffness, and cognitive decline. Curious? Come learn more! Please rate, review, and subscribe and if you have any questions, comments, concerns, queries, or complaints, please email me at neuroscienceamateurhour@gmail.com or DM me at NeuroscienceAmateurHour on Instagram.Also if you have the means/desire to financially support this podcast - please go to https://www.buymeacoffee.com/neuroscienceI really appreciate it!!!Citations and relevant papers are below. National Institute on Aging. Parkinson's Disease: Causes, Symptoms, and Treatments. National Institute on Aging. Hogg E, Frank S, Oft J, Benway B, Rashid MH, Lahiri S. Urinary Tract Infection in Parkinson's Disease. Journal of Parkinson's Disease. 2022;12(3):743-757. Yu J. Stages of Parkinson's | Parkinson's Foundation. www.parkinson.org. Published 2022. Zhang ZX, Dong ZH, Román GC. Early Descriptions of Parkinson Disease in Ancient China. Archives of Neurology. 2006;63(5):782. 2-Minute Neuroscience: Direct Pathway of the Basal Ganglia. www.youtube.com. 2-Minute Neuroscience: Indirect Pathway of the Basal Ganglia. www.youtube.com. Thanvi B, Lo N, Robinson T. Levodopa-induced dyskinesia in Parkinson's disease: clinical features, pathogenesis, prevention and treatment. Postgraduate Medical Journal. 2007;83(980):384-388. Zhang JF, Wang XX, Feng Y, Fekete R, Jankovic J, Wu YC. Impulse Control Disorders in Parkinson's Disease: Epidemiology, Pathogenesis and Therapeutic Strategies. Frontiers in Psychiatry. 2021;12. Hisahara S, Shimohama S. Dopamine Receptors and Parkinson's Disease. International Journal of Medicinal Chemistry. 2011;2011:1-16. Houston. Tmc.edu. Published October 20, 2020. https://nba.uth.tmc.edu/neuroscience/m/s3/chapter04.htmlOvallath S, Sulthana B. Levodopa: History and Therapeutic Applications. Annals of Indian Academy of Neurology. 2017;20(3):185-189. Levodopa | Parkinson's Foundation. www.parkinson.org. https://www.parkinson.org/living-with-parkinsons/treatment/prescription-medications/levodopaKelly MJ, Baig F, Hu MTM, Okai D. Spectrum of impulse control behaviours in Parkinson's disease: pathophysiology and management. Journal of Neurology, Neurosurgery & Psychiatry. 2020;91(7):703-711. Gerfen CR, Surmeier DJ. Modulation of Striatal Projection Systems by Dopamine. Annual Review of Neuroscience. 2011;34(1):441-466. Sayare S. The Woman Who Could Smell Parkinson's. The New York Times. https://www.nytimes.com/2024/06/14/magazine/parkinsons-smell-disease-detection.html. Published June 14, 2024. Blandini F, Nappi G, Tassorelli C, Martignoni E. Functional changes of the basal ganglia circuitry in Parkinson's disease. Progress in Neurobiology. 2000;62(1):63-88. Lanciego JL, Luquin N, Obeso JA. Functional Neuroanatomy of the Basal Ganglia. Cold Spring Harbor Perspectives in Medicine. 2012;2(12):a009621-a009621. Climate ConfidentWith a new episode every Wed morning, the Climate Confident podcast is weekly podcast...Listen on: Apple Podcasts SpotifySupport the Show.
How does CBD affect the CB1 receptor, really? Rob Laprairie is a cannabinoid researcher out of the University of Saskatchewan who was involved in the discovery of CBD's allosteric binding activity on the CB1 receptor – leading to a host of speculative theories about how CBD influences the activity of THC. In this conversation, continuing […]
Glucagon-like peptide 1 (GLP-1) is a hormone primarily known for its role in regulating blood sugar levels through its effects on insulin secretion and appetite control. However, recent research has shown another significant function of GLP-1: its ability to reduce inflammation. This opens new avenues for therapeutic interventions in various inflammatory conditions and chronic diseases. In this podcast, we'll discuss GLP-1's role in reducing inflammation and how it may help you. What is GLP-1? GLP-1 is an incretin hormone produced by intestinal L-cells in response to food intake. It enhances insulin secretion from the pancreas in a glucose-dependent manner. Here's how glucose-dependent insulin secretion works: Increase in Blood Glucose Levels: After you eat, carbohydrates in your food are broken down into glucose, which is absorbed into your bloodstream, raising your blood sugar levels. Release of GLP-1: In response to the rising blood glucose levels, your intestines release a hormone called GLP-1 (Glucagon-Like Peptide 1). Stimulation of the Pancreas: GLP-1 travels through your bloodstream to your pancreas, where it stimulates the beta cells in the pancreas to release insulin. Insulin Release: The insulin is then released into your bloodstream. Insulin acts like a key, allowing glucose to enter your cells so it can be used for energy. Glucose-Dependent Nature: The important part is that this whole process depends on the presence of glucose. If your blood glucose levels are not high, GLP-1 will not signal your pancreas to release insulin. This prevents your blood sugar from dropping too low, which could cause hypoglycemia (dangerously low blood sugar levels). GLP-1 also slows gastric emptying and reduces appetite, which collectively help manage postprandial blood glucose levels. GLP-1 exerts its effects by binding to the GLP-1 receptor (GLP-1R), which is expressed in multiple tissues, including the pancreas, brain, heart, and immune cells. The Link Between GLP-1 and Inflammation Inflammation is a complex response to harmful stimuli such as pathogens, damaged cells, or irritants. Chronic inflammation contributes to many diseases, including cardiovascular diseases, diabetes, and neurodegenerative disorders. How does GLP-1 reduce inflammation? Modulation of Immune Cells: GLP-1 influences various immune cells, including macrophages, T cells, and dendritic cells. It has been observed to shift macrophages from a pro-inflammatory (M1) to an anti-inflammatory (M2) phenotype, reducing the secretion of pro-inflammatory cytokines like TNF-α, IL-6, and IL-1β. This shift plays a crucial role in dampening the inflammatory response. Inhibition of Nuclear Factor-kappa B (NF-κB) Pathway: NF-κB is a transcription factor that regulates the expression of genes involved in inflammation. Activation of GLP-1R has been shown to inhibit the NF-κB pathway, thereby reducing the transcription of pro-inflammatory genes. This inhibition helps in lowering the levels of inflammatory mediators in the body. Reduction of Oxidative Stress: GLP-1 reduces oxidative stress by increasing the expression of antioxidant enzymes. Oxidative stress is a significant driver of inflammation, and by mitigating it, GLP-1 helps in lowering the inflammatory burden. This is particularly beneficial in conditions like atherosclerosis and diabetes, where oxidative stress is a major pathogenic factor. Cardiovascular Protection: Chronic inflammation is a well-known risk factor for cardiovascular diseases. GLP-1 and its analogs have been shown to improve endothelial function, reduce vascular inflammation, and protect against atherosclerosis. These effects are mediated through the reduction of inflammatory cytokines and oxidative stress, as well as the improvement of lipid profiles. Neuroprotection: Neuroinflammation is a critical component of neurodegenerative diseases such as Alzheimer's and Parkinson's disease. GLP-1 analogs have demonstrated neuroprotective effects by reducing neuroinflammation, improving neuronal survival, and enhancing cognitive function. These benefits are attributed to the reduction in pro-inflammatory cytokines and the enhancement of neurotrophic factors. Therapeutic Implications The anti-inflammatory properties of GLP-1 have significant therapeutic implications. GLP-1 receptor agonists, initially developed for the treatment of type 2 diabetes, are now being explored for their potential in treating various inflammatory and chronic diseases. Type 2 Diabetes and Metabolic Syndrome: The dual action of GLP-1 in regulating blood glucose and reducing inflammation makes it a promising therapeutic agent for managing type 2 diabetes and its complications. Cardiovascular Diseases: Given the role of inflammation in atherosclerosis and other cardiovascular conditions, GLP-1 analogs could offer cardiovascular protection and improve outcomes in patients with heart disease. Neurodegenerative Disorders: The neuroprotective and anti-inflammatory effects of GLP-1 analogs present a potential therapeutic strategy for slowing the progression of neurodegenerative diseases and improving cognitive function. Inflammatory Bowel Disease (IBD): Preliminary studies suggest that GLP-1 analogs may help in reducing inflammation in IBD, offering a novel treatment approach for this chronic inflammatory condition. Thanks again for listening to The Peptide Podcast. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week! We're huge advocates of elevating your health game with nutrition, supplements, and vitamins. Whether it's a daily boost or targeted support, we trust and use Momentous products to supercharge our wellness journey. Momentous only uses the highest-quality ingredients, and every single product is rigorously tested by independent third parties to ensure their products deliver on their promise to bring you the best supplements on the market.
BUFFALO, NY- May 22, 2024 – A new #research paper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 9, entitled, “Cell type-dependent modulation of senescence features using Weo electrolyzed water.” Electrolyzed-reduced water has powerful antioxidant properties with constituents that scavenge reactive oxygen species (ROS), which are known to be produced by several intrinsic and extrinsic processes. When there is an imbalance between ROS production and antioxidant defenses, oxidative stress occurs. Persistent oxidative stress leads to cellular senescence, an important hallmark of aging, and is involved in several age-related conditions and illnesses. In this new study, researchers Brenda L. Court-Vazquez, Shirley A. Arroyo-Vizcarrondo, Jonathan A. Poli, Lara Nyman, Kelly Halderman, Anthony Ginter, and Pierre-Yves Desprez from Weo LLC and California Pacific Medical Center investigated whether Weo electrolyzed water (WEW) could modulate the phenotype of senescent cells. “The focus of this study was to utilize two different cell types, human normal fibroblasts and human breast cancer cells, to investigate the impact of Weo electrolyzed water (WEW) on markers of cellular senescence, inflammation, and stress response genes.” The researchers compared normal human lung fibroblasts (BJ) and breast cancer cells (T47D) treated with hydrogen peroxide (H2O2) to induce senescence. They assessed the molecular impact of WEW on markers of cellular senescence, senescence-associated secretory phenotype (SASP) factors, and stress response genes. Treatment with WEW modulated markers of cellular senescence, such as the senescence-associated β-galactosidase (SA-β-gal) activity, EdU incorporation and p21 expression, similarly in both cell types. However, WEW modulated the expression of SASP factors and stress response genes in a cell type-dependent and opposite fashion, significantly decreasing them in BJ cells, while stimulating their expression in T47D cells. Reduction in the expression of SASP factors and stress-related genes in BJ cells suggests that WEW acts as a protective factor, thereby reducing oxidative stress in normal cells, while making cancer cells more sensitive to the effects of cellular stress, thus increasing their elimination and consequently reducing their deleterious effects. “In conclusion, we have shown here that the new technology developed by Weo, WEW, could attenuate the overall process of cellular senescence in both normal BJ fibroblasts and cancer T47D cells.” DOI - https://doi.org/10.18632/aging.205789 Corresponding authors - Brenda L. Court-Vazquez - bco@we-o.com, and Pierre-Yves Desprez - pydesprez@cpmcri.org Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, cellular senescence, senescence-associated secretory phenotype, oxidative stress, lung fibroblasts, breast cancer cells, senomorphic About Aging-US Aging publishes research papers in all fields of aging research, including but not limited to aging processes (from yeast to mammals), cellular senescence, age-related diseases (such as cancer and Alzheimer's disease) and their prevention and treatment, anti-aging strategies and drug development, and, importantly, the role of signal transduction pathways in aging (such as mTOR) and potential approaches to modulate these signaling pathways to extend lifespan. Please visit our website at https://www.Aging-US.com and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM
Commentary by Dr. Valentin Fuster
Unreal Results for Physical Therapists and Athletic Trainers
In this episode of the Unreal Results podcast, I'm talking about a topic that's been on my mind as of late: the connection between the menstrual cycle and ACL tears. First & foremost, I truly believe that everyone, including non-healthcare providers & men, should understand the menstrual cycle and how it affects the body's hormones. I challenge the general assumptions made about ligament laxity and when ligamentous injuries frequently occur by analyzing what's actually happening during the menstrual cycle. I also talk about ALL of the ways that female athletes can reduce their risk of ACL tears and other ligamentous injuries. I hope that you're able to have some excellent takeaways from this episode and share them with anyone that has a female in their life!Resources Mentioned In This Episode:The Period Repair Manual by Lara Briden*Tina Haupert - CarrotsnCake on IGEpisode 58: The Whole Organism Approach w/ Dr. Nicole CozeanEpisode 49: Pain On The SacrumEpisode 25: The Peripheral HeartEpisode 20: Reflexive Core Stability: Lessons From My Back Surgery - Part 3Sacrum Pain - Relief Exercises You Haven't Tried... - YouTube VideoResearch Articles- Sensitivity of the fasciae to sex hormone levels: Modulation of collagen-I, collagen-III and fibrillin production- The Menstrual Cycle, Sex Hormones, and Anterior Cruciate Ligament Injury- Cyclic variations in multiplanar knee laxity influence landing biomechanics- Sex differences in knee joint laxity change across the female menstrual cycle- The effects of the menstrual cycle on anterior knee laxity: a systematic review*This link is an Amazon affiliate link, meaning I earn a commission from any qualifying purchases that you makeConsidering the viscera as a source of musculoskeletal pain and dysfunction is a great way to ensure a more true whole body approach to care, however it can be a bit overwhelming on where to start, which is exactly why I created the Visceral Referral Cheat Sheet. This FREE download will help you to learn the most common visceral referral patterns affecting the musculoskeletal system. Download it at www.unrealresultspod.com=================================================Watch the podcast on YouTube and subscribe!Join the MovementREV email list to stay up to date on the Unreal Results Podcast and MovementREV education. Be social and follow me:Instagram | Facebook | Twitter | YouTube
Send us a Text Message.Episode 131 of the Long Covid Podcast is a chat with the wonderful Dr Wes Ely, internist & pulmonologist, clinical triallist & also author & Long Covid advocate. We chat through some of his experiences with Long Covid patients as well as the clinical trial of baricitinib for Long Covid which is enrolling very soon.ICUdelirium.org Stat News - "Don't give longhaulers the silent treatment"RVLC - Reverse Long Covid trial on Clinicaltrials.gov RVLC Trial websiteEvery Deep Drawn Breath bookCOV-BARRIER study For more information about Long Covid Breathing, their courses, workshops & other shorter sessions, please check out this link(music - Brock Hewitt, Rule of Life) Support the Show.~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~The Long Covid Podcast is self-produced & self funded. If you enjoy what you hear and are able to, please Buy me a coffee or purchase a mug to help cover costs.Transcripts are available on the individual episodes hereShare the podcast, website & blog: www.LongCovidPodcast.comFacebook @LongCovidPodcastInstagram & Twitter @LongCovidPodFacebook Support GroupSubscribe to mailing listPlease get in touch with feedback and suggestions or just how you're doing - I'd love to hear from you! You can get in touch via the social media links or at LongCovidPodcast@gmail.com**Disclaimer - you should not rely on any medical information contained in this Podcast and related materials in making medical, health-related or other decisions. Ple...
In today's episode, we explore the role of Thymosin Alpha 1 Peptide in modulating the immune system, specifically its effects on Th1 and Th2 responses. The episode further delves into the mechanisms by which Borrelia burgdorferi evades immune detection and offers strategies to enhance immune effectiveness against this stealthy pathogen. Additionally, we discuss the broader implications of immune modulation in chronic Lyme disease and mold exposures. Topics: Introduction Recap of the series on Lyme and mold Highlighting the key steps in the biotoxin illness resolution process Importance of working with a medical professional Key Steps in Biotoxin Illness Resolution Lowering inflammation Lipid replacement therapy (phospholipids) Use of antimicrobial and antiparasitic herbs for Lyme and coinfections Employing binders to eliminate toxins and reduce inflammation Checking for MARCoNS and utilizing treatments like silver spray or biofilm busters (e.g., xylitol) Detoxification post-MARCoNS clearance using agents like chlorella and glutathione Assessing and normalizing various health markers (e.g., ADH, osmolality, MMP9, C4a, C3a, TGF-beta, sex hormones) Additional Resources and Episodes Early stages of Lyme infection and Herxheimer reaction: Episode 116 Chronic inflammation and biotoxin management: Episode 117 Role of binders in interrupting enterohepatic circulation and toxin elimination Discussion on Biofilm Importance of addressing biofilm in antimicrobial therapies Potential supplements and strategies (e.g., garlic, oil of oregano, stevia) Overview of Lyme Disease Impact & Immune Function Chronic inflammation due to miscommunication between the innate and adaptive immune systems + dysregulated adaptive responses How borrelia evades the immune responses Immunomodulation in Lyme Disease Background on immune modulation Role of T cells in adaptive immune response Th1 and Th2 cell imbalance in chronic Lyme Strategies to support Th1 cells and decrease Th2 response Focus on Thymosin Alpha 1 Benefits of Thymosin Alpha 1 in modulating immune function Promoting Th1 response and managing Th2 dominance Effects on regulatory T cells (Tregs) and immune tolerance Conclusion Reminder to work with a Lyme literate or biotoxin illness literate medical professional Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in! --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support
Teaching Tip 361 | “Plain Speaking - Speak With an Interesting and Clear Voice” | Malcolm Cox Introduction Here is your 2-minute tip based on the book, “Plain speaking: How to preach and teach effectively" by David Bercot. It is crucial to know what we are talking about and present it with confidence and conviction. However, what difference does the quality of our voice make? Bercot makes this observation: “In daily conversation, we seem naturally to know how to make our voice pleasant and interesting. We rarely speak in a monotone when talking to friends. but somehow when we're in front of a congregation we forget to do what comes naturally. That's why every speaker needs to consciously speak with modulation.” 85 What does this look like? Modulation. We're talking about variety in pitch, volume, tone and emphasis. Read one of the parables. Can you imagine Jesus sharing it with no variation in his voice? A monotone? I hardly think so. Where do you think he might have placed emphasis—speaking louder, more softly or slowly? Take the parable of the Pharisee and the tax collector in Luke 18. I'm pretty sure he relayed the Pharisee's prayer at high volume (“‘God, I thank you that I am not like other people—robbers, evildoers, adulterers—or even like this tax collector. I fast twice a week and give a tenth of all I get.'” (Luke 18:11-12 NIV11), and the tax collector's at low volume (“‘God, have mercy on me, a sinner.'” (Luke 18:13 NIV11) Volume, Tempo, and Pausing. Can you be heard by everyone in the room? Look at the back as you start speaking and take note if it looks as if they are straining to hear you. The bigger the group and the larger the room, the slower we need to speak. Sound tends to get garbled the further it travels. Pauses help your audience ‘breathe' as they listen. A small gap here and there in your lesson will help them to grasp your point. Use dramatic pauses sparingly but meaningfully. See the example of Jesus in Mark 3:1-6 and imagine the effect of the silence. Enunciation. I vividly remember the person who preached on the text, “Blessed are those who mourn, for they will be comforted.” (Matthew 5:4 NIV11) His accent was strong. It sounded like he was saying, “Blessed are those who moan”. Once would not have been too bothersome, but it was the main phrase of the lesson and repeated multiple times. The congregation did not know whether to ask him to speak more clearly, try to ignore it, or laugh. It was embarrassing, distracting and avoidable. What are your thoughts on cultivating an interesting and clear voice? Conclusion Next time, we will go on to look at five things that can spoil an otherwise good sermon. Has today's tip been worth two minutes of your time? I hope so. Remember to keep calm and carry on teaching. Consider joining AIM UK&Ireland to develop your understanding of Scripture: https://aimukandireland.com/. Our next module is Spiritual Life. Contact us here with enquiries: courses@aimukandireland.com The website can be found here: https://aimukandireland.com Please add your comments on this week's topic. We learn best when we learn in community. Do you have a question about teaching the Bible? Is it theological, technical, or practical? Send me your questions or suggestions. Here's the email: [malcolm@malcolmcox.org](mailto:malcolm@malcolmcox.org). If you'd like a copy of my free eBook on spiritual disciplines, "How God grows His people", sign up at my website: http://[www.malcolmcox.org](http://www.malcolmcox.org/). Please pass the link on, subscribe, and leave a review. Remember to keep calm, and carry on teaching. God bless, Malcolm
Today we're joined by Joel Korte of Chase Bliss! Joel's an inspiring figure in the gear industry, both for his engineering and his being-a-great-human. We get to know his story through the lens of the ZVEX Lo-Fi Loop Junky, a unique design using the ChipCorder voice recording chip to create short, compressed, warbling loops. We learn how Joel found himself at ZVEX, how he went from being a fan of the pedal to reinterpreting its sound as the Instant Lo-Fi Junky, and how he eventually went on to create Chase Bliss. This episode is about perseverance, engineering, and some goofs along the way - get in!Buy Chase Bliss pedals: https://www.chasebliss.com/Listen to Mostly Trees: https://mostlytrees.bandcamp.com/Buy Old Blood pedals: http://www.oldbloodnoise.comJoin the conversation in Discord: https://discord.com/invite/PhpA5MbN5uFollow us on the socials: @chasebliss, @oldbloodnoise, @andyothling, @danfromdsfLeave us a voicemail at 505-633-4647!
The Promise of Discovery Season 4, Episode 4 This research examines mGlu7, a transmembrane receptor involved in several neurodevelopmental disorders, such as Rett syndrome, ADHD, schizophrenia, and Neurofibromatosis Type 1. The project discussed studies the mechanism of mGlu7 activation by allosteric modulators to develop new treatments and help guide drug discovery efforts. Featuring: Xia Lei, Ph.D., postdoctoral fellow, Vanderbilt University Interviewer: Colleen Niswender, Ph.D., associate professor of Pharmacology; Director of Molecular Pharmacology, Warren Center for Neuroscience Drug Discovery; and a Vanderbilt Kennedy Center Member
Before “co-authored, interactive erotica” (otherwise known as sexting), we had chatrooms. Virtual spaces where anyone of any race, gender, class, or creed could come together to fornicate with their words. The MUD and MOO chatrooms of yore belonged to a time when Dungeons and Dragons nerds governed the internet - a utopia of beautiful, unadulterated cybersex. But one fateful day in 1993, this would all change. In this episode, Hannah and Maia discuss the origins of online chatrooms, their dark corners, and eventual evolution into child-oriented platforms (like Habbo Hotel and Club Penguin). Digressions include: beautiful house theory, “meat puppets”, Richard Nixon's brief stint on IMVU, and Maia repeatedly confusing AOL for AIM. SOURCES Rachel Seifert, “Striptease and cyber sex: my stay at Habbo Hotel” Channel 4 News, (2012) https://www.channel4.com/news/striptease-and-cyber-sex-my-stay-at-habbo-hotel Paraic O'Brien, “Should you let your child play in Habbo Hotel?” Channel 4 News, (2012)https://www.channel4.com/news/should-you-let-your-child-play-in-habbo-hotel William J. Shefski, Interactive Internet: the insider's guide to MUDs, MOOs and IRC, (1995) https://archive.org/details/isbn_9781559587488/page/n16/mode/1up Habbo, Wikipedia https://en.wikipedia.org/wiki/Habbo Sara Morais dos Santo Bruss, “CHAPTER 1: The Internet Imaginary and Digital Modernity” Feminist Solidarities after Modulation (2023) https://www.jstor.org/stable/jj.10782316.4 Steve Downey, “History of the (Virtual) Worlds”, The Journal of Technology Studies, Vol. 40, No. 2 (Fall 2014) https://www.jstor.org/stable/43604309 Sherry Turkle, “Tinysex and Gender Trouble” Sex/Machine: Readings in Culture, Gender, and Technology (1998) Dennis Waskul, Mark Douglass, Charles Edgley, “Cybersex: Outercourse and the Enselfment of the Body” Symbolic Interactions, Vol. 23, No. 4 (2000) https://www.jstor.org/stable/10.1525/si.2000.23.4.375 Samantha Cole, How Sex Changed the Internet and the Internet Changed Sex, Workman Publishing (2022) Julian Dibbell, “A Rape in Cyberspace (or TINYSOCIETY and How to Make One)” My tiny life: crime and passion in a virtual world, Henry Holt (1998)
GLP-1 agonists like semaglutide exert anti-inflammatory effects through many mechanisms. This has significant implications for health, particularly in conditions characterized by chronic inflammation such as obesity, diabetes, and neurodegenerative diseases. In this podcast, we'll talk about how GLP-1 agonists produce their anti-inflammatory effects and the potential benefits associated with these actions. How do GLP-1 Agonists Fight Inflammation? Modulation of Immune Responses: GLP-1 plays a crucial role in controlling the activity of immune cells involved in inflammation. It can dampen the response of immune cells called macrophages, which are key players in the inflammatory process. By reducing the production of pro-inflammatory molecules and promoting the release of anti-inflammatory substances, GLP-1 helps restore balance to the immune system. Inhibition of Inflammatory Pathways: GLP-1 exerts its anti-inflammatory effects by interfering with various signaling pathways that drive inflammation. For example, it can block the activation of nuclear factor-kappa B (NF-κB), a central regulator of inflammation that triggers the expression of pro-inflammatory genes. By inhibiting NF-κB and other inflammatory pathways, GLP-1 helps suppress the production of inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and interleukin-1 beta (IL-1β). Reduction of Oxidative Stress: Oxidative stress, caused by an imbalance between free radicals and antioxidants in the body, contributes to inflammation and tissue damage. GLP-1 helps mitigate oxidative stress by enhancing antioxidant defenses and scavenging free radicals. By reducing oxidative damage, GLP-1 helps alleviate inflammation and protect cells from harm. What are the potential benefits of GLP-1's anti-inflammatory effects? Improved Metabolic Health: Chronic inflammation is closely linked to metabolic disorders such as obesity, insulin resistance, and type 2 diabetes. By combating inflammation, GLP-1 may improve metabolic health and help control blood sugar levels in individuals with diabetes. This can reduce the risk of complications associated with these conditions, such as cardiovascular disease and kidney damage. Protection Against Cardiovascular Disease: Inflammation plays a significant role in the development of cardiovascular diseases such as atherosclerosis, heart attack, and stroke. GLP-1's anti-inflammatory effects help protect blood vessels and the heart from inflammation-induced damage, reducing the risk of cardiovascular events and improving overall heart health. Potential for Neuroprotection: Inflammation in the brain is implicated in neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. GLP-1's ability to reduce neuroinflammation may have neuroprotective effects, preserving cognitive function and slowing the progression of these diseases. Alleviation of Autoimmune Conditions: Autoimmune diseases, where the immune system mistakenly attacks healthy tissues, are characterized by chronic inflammation. GLP-1's anti-inflammatory properties may help alleviate symptoms and reduce disease activity in conditions such as rheumatoid arthritis, inflammatory bowel disease, and psoriasis. Thanks again for listening to The Peptide Podcast. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week! We're huge advocates of elevating your health game with nutrition, supplements, and vitamins. Whether it's a daily boost or targeted support, we trust and use Momentous products to supercharge our wellness journey. Momentous only uses the highest-quality ingredients, and every single product is rigorously tested by independent third parties to ensure their products deliver on their promise to bring you the best supplements on the market.
In this Psychedelic Podcast episode, Paul F. Austin welcomes Will Rezin, mystic, philosopher, and coach, to explore the worlds of psychedelics, somatics, and trauma healing. Find episode links, summary, and transcript here: https://thethirdwave.co/podcast/episode-224-will-rezin/ Dive into Will's profound healing path, shaped by ayahuasca in Peru. Together, Will and Paul go beyond the conventional body-mind separation, drawing on key approaches to healing common to both somatics and psychedelics. Their conversation envisions a trauma-free future that extends beyond personal healing to embrace relational, societal, and environmental transformations. Will Rezin: Will Rezin is a mystic and somatic teacher. He is a leading expert in the field of personal development with a focus on trauma education and somatics. Will has a unique approach that combines somatic practices, early developmental movement theory, esoteric philosophy and trauma theory with traditional coaching methods. He's the co-founder of Trauma and Somatics where he trains practitioners to become trauma-informed, and the co-founder of The Truth Foundation where he and his co-founder, David Gonzalez, are on a mission to End Trauma. Over the past 18 years, Will has immersed himself in studying human development through the lens of culture, psychology, biology, physiology, mysticism, myth and behavioral change. He is trained in Somatic Experiencing®, Core Energy Leadership Coaching, Early Developmental Trauma, Karmic Astrology, Jungian Archetypal Psychology, Ericksonian Hypnosis, Amazonian Shamanism and much more. Will integrates many therapeutic models into his work with clients and his teaching with students. Highlights: Exploring the work of Dr. Peter A. Levine. Will's psychedelic healing path and ayahuasca experiences in Peru: Beyond the body-mind separation: unpacking somatics. Essence vs. Personality: integrating intuition and wisdom. Modulation and titration: keys to healing in somatics and psychedelics. Will's mission to eradicate trauma in the world. Envisioning AI's role in healing trauma. Beyond personal healing: relational, societal, and environmental transformation. Episode Sponsors: Apollo Neuro - Third Wave listeners get 15% off. Psyched Wellness - use code THIRDWAVE23 to get 15% off. Magic Mind - Enjoy up to 56% off when applied to a 10-day subscription
On this week's podcast, Paul addresses the link between hair loss and nutrient deficiencies. He touches on different kinds of hair loss such as male patterned hair loss, female patterned hair loss, alopecia areata, and telogen effluvium, and highlights some of the problems with the mainstream treatment methods for these conditions. 00:06:50 Anecdotes on hair regrowth 00:11:40 Different types of hair loss 00:16:00 Nutrient deficiencies that may lead to hair loss 00:39:20 Thoughts on biotin 00:43:10 Concerns with mainstream hair loss therapy 00:47:10 Testosterone lowering foods to avoid References: The Nutrition Source, Zinc: https://www.hsph.harvard.edu/nutritionsource/zinc/ A Cross-sectional Study of Plasma Trace Elements and Vitamins Content in Androgenetic Alopecia in Men: https://pubmed.ncbi.nlm.nih.gov/33151470/ Plasma Zinc Levels in Males with Androgenetic Alopecia as Possible Predictors of the Subsequent Conservative Therapy's Effectiveness: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277952/ The Role of Vitamins and Minerals in Hair Loss: A Review: https://pubmed.ncbi.nlm.nih.gov/30547302/ The Effect of a Food Supplement and a Hair Lotion on the Progression of Androgenetic Alopecia: https://www.scirp.org/journal/paperinformation.aspx?paperid=96669 Efficacy and tolerability of an oral supplement containing amino acids, iron, selenium, and marine hydrolyzed collagen in subjects with hair loss (androgenetic alopecia, AGA or FAGA or telogen effluvium). A prospective, randomized, 3-month, controlled, assessor-blinded study: https://pubmed.ncbi.nlm.nih.gov/37357646/ Protective effects of taurine on human hair follicle grown in vitro: https://pubmed.ncbi.nlm.nih.gov/18489269/ Management of hair loss in women: https://pubmed.ncbi.nlm.nih.gov/8435917/ The Therapeutic Effect and the Changed Serum Zinc Level after Zinc Supplementation in Alopecia Areata Patients Who Had a Low Serum Zinc Level: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2861201/ Post-finasteride syndrome: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253896/ Pilot study of dietary fat restriction and flaxseed supplementation in men with prostate cancer before surgery: exploring the effects on hormonal levels, prostate-specific antigen, and histopathologic features: https://pubmed.ncbi.nlm.nih.gov/11445478/ Isoflavone-rich soy protein isolate suppresses androgen receptor expression without altering estrogen receptor-beta expression or serum hormonal profiles in men at high risk of prostate cancer: https://pubmed.ncbi.nlm.nih.gov/17585029/ Modulation of AKR1C2 by curcumin decreases testosterone production in prostate cancer: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5891173/ Sponsors: Heart & Soil: www.heartandsoil.co Sign up for Animal Based Gathering 2023: animalbasedgathering.com Make a donation to the Animal Based Nutritional Research Foundation: abnrf.org Bon Charge: boncharge.com, use code CARNIVOREMD for 15% off your order Zero Acre: www.zeroacre.com/PAUL or use code PAUL for free shipping on your first order Calima Salt: drpaulsalt.com, for a free bag of Calima Sea Salt
Dr. Steve Ramirez is an Assistant Professor in the Department of Psychological and Brain Sciences at Boston University. In his research, Steve is studying learning and memory, and he is interested in discovering whether it is possible to artificially turn memories on and off. His research focuses on understanding the brain and what we can do when processes in the brain break down. They are working on turning on positive or negative memories in animal models to gain a better understanding of how the brain and memory work. In addition, they use animal models of conditions like depression, anxiety, and PTSD to study whether artificially manipulating memories may alleviate some of the symptoms of these conditions. Steve was born and raised in the Boston area, so accepting a faculty position at Boston University meant reuniting with his family, friends, and beloved New England Patriots. He spends his down time watching Netflix with friends and hanging out with his family. He attended Boston University for his undergraduate studies in neuroscience, was awarded his PhD in Brain and Cognitive Sciences from the Massachusetts Institute of Technology, served as a Visiting Lecturer of Neuroscience at Tufts University while a graduate student, and spent two years at the Center for Brain Science at Harvard University as a Junior Fellow of the Society of Fellows before returning to Boston University as a faculty member. Steve has received many awards and honors thus far in his career, including an NIH Early Independence Award, a NARSAD Young Investigator Award, the Gordon Research Conference Travel Award, the American College of Neuropsychopharmacology Travel Award, Smithsonian Magazine's American Ingenuity Award in the Natural Sciences, the Walle Nauta Award for Continuing Dedication to Teaching at MIT, and the Angus MacDonald Award for Excellence in Undergraduate Teaching at MIT. Steve has also been named among Forbes Magazine's 30 Innovators Under the Age of 30 in the area of Science and Technology, a National Geographic Breakthrough Explorer, one of Science News's Top 10 Bright Young Minds, Pacific Standard Magazine's Top 30 Thinkers Under the Age of 30, and the MIT Technology Review World's Top 35 Innovators Under the Age of 35 Award. He has also given two TED talks. In this interview, Steve talks about his experiences in life and science.