Programmed cell death in multicellular organisms
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In this episode, Dr. Jockers and Ben Azadi discuss metabolic freedom and its impact on longevity and inflammation. You'll learn why staying in sugar-burning mode harms your health and how fat-burning mode promotes healing. Ben shares his journey from obesity to metabolic health and explains why metabolic flexibility is key to disease prevention. He highlights how fasting resets your metabolism and activates autophagy for cellular repair. Discover how insulin affects fat burning and why lowering its levels boosts energy. Ben also covers how the right foods support metabolic health and the importance of reducing constant snacking. In This Episode: 00:00 The Shocking Truth About French Fries and Cigarettes 03:08 Metabolic Freedom: Key to Longevity 05:18 Understanding Metabolic Health 06:35 The State of Metabolic Health in America 11:01 The Importance of Insulin in Metabolic Health 17:56 Calories vs. Hormones: The Real Debate 20:46 Feast and Famine: Ancestral Eating Patterns 26:06 The Dangers of Seed Oils 29:40 Healthy Fats vs. Seed Oils 30:07 The Hidden Dangers of Canola Oil 30:27 Avoiding Seed Oils When Dining Out 30:50 The Impact of Seed Oils on Your Body 31:09 Understanding Stomach Acid and Digestion 32:19 The Benefits of Digestive Bitters 32:58 Autophagy: The Body's Cleanup Process 33:33 The Role of Phosphatidylcholine 33:55 Autophagy and Fasting 34:03 The Refrigerator Analogy for Autophagy 35:17 The Process of Apoptosis 35:29 Fasting and Exercise 36:31 The Importance of Metabolic Flexibility 37:53 Preparing for Fasting 41:15 The Concept of Hormesis 43:34 Balancing Cortisol and Growth Hormone 48:02 Daily Routines for Optimal Health 52:56 The Wolverine Stack for Recovery Looking for a delicious snack that's good for you? Paleovalley Superfood Bars are packed with organic, whole food ingredients like collagen protein, kale, and blueberries—providing all the nutrients your body needs. With flavors like Lemon Meringue and Red Velvet, you can enjoy a treat that supports gut health, joint function, and even wrinkle-free skin. Visit Paleovalley.com and use the code JOCKERS to save 15% on your order today. Snack smarter with Paleovalley Superfood Bars! Struggling with digestion? Just Thrive Digestive Bitters help stimulate the production of stomach acid, bile, and pancreatic enzymes, improving digestion, easing bloating, and enhancing nutrient absorption. It's the natural way to support your gut health and feel better after every meal. Visit justthrivehealth.com and use code JOCKERS to save 20% off your order! "Metabolic freedom is about being able to burn fat when you need to and burn sugar when you need to." ~ Dr. Jockers Subscribe to the podcast on: Apple Podcast Stitcher Spotify PodBean TuneIn Radio Resources: Paleovalley - visit paleovalley.com/jockers Visit justthrivehealth.com and use code Jockers for a 20% discount Connect with Ben Azadi: Website: https://www.benazadi.com/ Book: https://amzn.to/41O02jk Connect with Dr. Jockers: Instagram – https://www.instagram.com/drjockers/ Facebook – https://www.facebook.com/DrDavidJockers YouTube – https://www.youtube.com/user/djockers Website – https://drjockers.com/ If you are interested in being a guest on the show, we would love to hear from you! Please contact us here! - https://drjockers.com/join-us-dr-jockers-functional-nutrition-podcast/
How does chemotherapy work and why does it cause side effects? We answer these questions and more in this episode as we continue our series about cancer with a discussion about chemotherapy. https://bit.ly/42HvhykIn this Episode:03:31 - Travel: Rhode Island and Clam Cakes04:35 - Anna Quindlen - We Need to "Get a Life"08:45 - Chemotherapy Overview: How it works, Cycles, Port12:19 - Types of Chemotherapy Drugs15:35 - Apoptosis and Chemo Success17:04 - Side Effects of Chemotherapy18:02 - Discussion - "How Long Has Chemo Been in Use?"21:41 - Jeena R. Papaadi, "The Person in the Bed"24:51 - OutroRelated Episodes:S6E4: Understanding Cancer Treatment Options: ImmunotherapyS6E3: Understanding Cancer Treatment Options: Radiation TherapyS6E2: Understanding Cancer Treatment Options: SurgeryS5E52: Cancer Gone Wild – Learn All About MetastasisS5E45: Why Does Cancer Exist? Empower Yourself With UnderstandingS5E46: “Why Do I Have Cancer?” Kismet, Chastisement or Coincidence?S5E47: MythBusters – Cancer Edition; Clarifying Common Cancer Myths & MisconceptionsS5E48: How to Read a CT Scan Report – Learn the Sections Relevant to Your DiagnosisS5E49: Are there Miracle Cures for Cancer? With Dr. Jeanna FordS5E50: What is Meant by Cancer Staging? Learn the Language of a Cancer Diagnosis#cancer #cancertreatment #cancertreatmentoptions #chemotherapyeducation #palliativecare #cancereducation #cancerresources #sideeffects #everydayisagift #everyonediesSupport the showGet show notes and resources at our website: every1dies.org. Facebook | Instagram | YouTube | mail@every1dies.org
Matters Microbial #81: Viruses, Innate Immunity, and Undergraduates March 5, 2025 Today, Dr. Brianne Barker, Associate Professor of the Biology Department at Drew University, joins the #QualityQuorum to discuss how her undergraduate research group studies how innate immune mechanisms of cells recognize viral invasion. Host: Mark O. Martin Guest: Brianne Barker Subscribe: Apple Podcasts, Spotify Become a patron of Matters Microbial! Links for this episode A video describing the immune system, both innate and adaptive. More of a focus on mechanisms of innate immunity, the focus for today. A description of basic immune cells. An introductory video describing the viral reproductive cycle in general. A description of PRRs (pattern recognition receptors) and MAMPs (microbially associated molecular patterns) An overview of interferons and disease. An introductory video overview of programmed cell death, called apoptosis. The role that retroviruses play in producing blue eggs in chickens. Here is a very introductory summary. The role that retroviruses play in placental mammals, including humans. How do cells recognize invading DNA during viral infection? A research paper by Dr. Barker's research group. Dr. Barker on This Week in Virology. Dr. Barker's faculty website. Dr. Barker's research group website. Intro music is by Reber Clark Send your questions and comments to mattersmicrobial@gmail.com
On the 434th episode of Piecing It Together, we are LIVE from Maya Cinemas in Las Vegas with guests Faith Nault, Jorge Lara and Kristopher West to talk about Captain America: Brave New World. The latest entry in the Marvel Cinematic Universe doesn't exactly move things forward like fans had hoped, but we had a good time with it anyway. Puzzle pieces include The Manchurian Candidate, Bond movies, Who Framed Roger Rabbit and a bunch of X-Men movies that we have trouble distinguishing between.As always, SPOILER ALERT for Captain America: Brave New World and the movies we discuss!Written by Rob EdwardsDirected by Julius OnahStarring Anthony Mackie, Harrison Ford, Danny Ramirez, Shira Haas, Tim Blake Nelson, Giancarlo EspositoMarvelhttps://www.marvel.com/movies/captain-america-brave-new-worldFaith Nault is an award winning short film director, writer, and sound designer. She recently graduated magma cum laude from UNLV with a film degree and continues to work freelance in film/television. Check out Faith's work at https://linktr.ee/faithnaultFollow Faith on Instagram @strongfaith1Jorge Lara is a photographer and is the editor in chief of VIM Magazine.Check out VIM Mag at https://www.vimmag.com/Check out Jorge on Instagram @worldofjorgelaraKristopher West is a podcaster and filmmaker. He co-hosts the Reel Sick Podcast and Spiral Out Podcast.Check out the Reel Sick Podcast at https://www.reelsickpodcast.com/Check out the Spiral Out Podcast at https://www.spiraloutpodcast.com/Check out his latest film Apoptosis on YouTube at https://www.youtube.com/watch?v=BqfuLz4IlSMAnd Follow Reel Sick Podcast on Instagram @reelsickpodcastMy latest David Rosen album MISSING PIECES: 2018-2024 is a compilation album that fills in the gaps in unreleased music made during the sessions for 2018's A Different Kind Of Dream, 2020's David Rosen, 2022's MORE CONTENT and 2025's upcoming And Other Unexplained Phenomena. Find it on Bandcamp, Apple Music, Spotify and everywhere else you can find music.You can also find more about all of my music on my website https://www.bydavidrosen.comMy latest music video is “Shaking" which you can watch at
In this episode of the Gladden Longevity Podcast, Dr. Mike Van Thielen shares his extensive journey in health and wellness, focusing on the benefits of molecular hydrogen. He discusses his background in physical therapy, acupuncture, and holistic nutrition, leading to his interest in longevity and anti-aging. The conversation delves into the science behind molecular hydrogen, its role as a selective antioxidant, and its adaptogenic properties. Dr. Van Thielen also explains various methods of hydrogen delivery and its applications for gut health, emphasizing the importance of balance in health interventions. For the audience: * Use the code 'Podcast10' to get 10% OFF your order at our supplement store → https://gladdenlongevityshop.com/ * Get Mike Van Thielen's book, the Hydrogen of your choice and access to ALL the research → https://mvtonline.com/molecular-hydrogen Takeaways * Molecular hydrogen is gaining recognition for its therapeutic benefits. * Hydrogen acts as a selective antioxidant, neutralizing harmful free radicals. * It functions as an adaptogen, helping to balance bodily functions. * Hydrogen promotes autophagy, aiding in cellular recycling. * Hydrogen can cross the blood-brain barrier, offering neuroprotective effects. * It is cytoprotective, benefiting mitochondrial health and energy production. * Hydrogen is effective for gut health, improving conditions like leaky gut. * Different delivery methods for hydrogen can be combined for optimal results. Chapters 00:00 Introduction to Dr. Mike Van Thielen 05:51 Journey into Health and Longevity 13:46 Exploring Molecular Hydrogen 24:56 The Science Behind Hydrogen's Benefits 30:27 Hydrogen Delivery Methods and Dosing 41:08 Hydrogen for Gut Health and Conclusion 42:59 Goodbye To learn more about Mike, get his help, his books or contact him: Website: https://drmike.dna.clinic/ Website: https://mvtonline.com/ Instagram: https://www.instagram.com/drmike_health4life/?hl=en Facebook: https://www.facebook.com/drmikeinspires/ Reach out to us! Website: https://gladdenlongevity.com/ Email: podcast@gladdenlongevity.com Facebook: https://www.facebook.com/Gladdenlongevity/ Instagram: https://www.instagram.com/gladdenlongevity/?hl=en LinkedIn: https://www.linkedin.com/company/gladdenlongevity YouTube: https://www.youtube.com/channel/UC5_q8nexY4K5ilgFnKm7naw
Send us a textWelcome to this mini episode of Deathless where we break down the latest headlines in the news about immortality. To help me, Pulitzer winning journalist from The Times... Hannah Altenbach.Main Story: ApoptosisGeneticists are exploring a new gene therapy that would program human cells to die all at once. In effect: a death virus. On the Lighter Side: Norah's ArkThe latest death alternative is a closed-loop cruise line designed specifically for the super elderly. Bon voyage, I guess?(***Hannah Altenbach is portrayed by Becca Schneider)Follow us on Instagram @deathlesspodAnd one more thing... How's your immortality going?
In this episode of the Vibe Science podcast, hosts Ryan Alford and Chris Hansen delve into the science of health optimization and longevity with Dr. Vanessa Pavy, a naturopathic doctor from Life Extension. Together, they explore the transformative potential of supplements, highlighting key compounds like fisetin and paraquinone (PK). Dr. Peavy sheds light on fisetin's role in clearing senescent cells and PK's impact on enhancing mitochondrial function. The discussion emphasizes the value of personalized health strategies, the importance of routine blood work, and the vital roles of nutrients like CoQ10 and lipoic acid in supporting energy production and overall wellness.TAKEAWAYSTheme of longevity and health optimizationImportance of personalized health managementDiscussion of various supplements and their benefitsIntroduction and explanation of fisetin as a senolytic compoundRole of senescent cells in aging and healthImportance of telomeres in cellular healthMonitoring health through regular blood work and biomarkersEmerging supplements like ergothioneine and their benefitsImpact of mitochondrial health on overall well-beingRelationship between aging and the decline of CoQ10 production Follow us on Instagram: @Vibe.Science Subscribe to our YouTube Page: www.youtube.com/@Vibe.Science
Last month I was invited to speak at a functional medicine symposium in Rome, Italy. This is the same conference where I gave an in-depth presentation explicitly on photobiomodulation two years prior. This time around, I spoke on the term/theory I have coined: The Mitochondrial Triad.As many of you know by this point, this Triad is, what I believe to be at this point in time based on the information I have gathered, the three most efficient and efficacious ways to boost your mitochondrial function: red light therapy, methylene blue and carbon 60. The presentation I gave first explained why the mitochondria are the focal point of this Triad and justified why the crux of modern health and disease is predicated on mitochondrial function; or said another way, why mitigating and preventing mitochondrial dysfunction is the ultimate goal of wellness and longevity. The subsequent sections of the presentation are on RLT, MB and C60 and how they positively impact the mitochondria and, thus, can positively affect the vast majority of diseases and cancers.So for today's episode, I decided to provide you with a front row seat to my presentation. Not a recording of the one I gave in Rome, but a personal The Red Light Report rendition, which has ended up being more comprehensive and detailed. Sit back and enjoy the first half of my presentation, which covers the impact of mitochondria on our overall health and red light therapy. If you found the information in today's episode particularly interesting and/or compelling, please share it with a family member, friend, colleague and/or anyone that you think could benefit and be illuminated by this knowledge. Sharing is caring :)As always, light up your health! - Key Points: [0:00] Easy Water: The Mitochondrial Battery [2:30] Voltage Levels and Cell Health [4:00] Infrared and Sunlight: Building EZ Water [6:50] UV Light Benefits and Sunglasses Consideration [9:10] Positive Energy and Easy Water Formation [11:45] Mitochondrial Dysfunction Explained [14:00] Diseases Linked to Mitochondrial Dysfunction [16:20] Red Light Therapy for Mitochondrial Health [20:27] Mitochondria as Batteries [21:14] Voltage, Electrons, and Inflammation [21:46] Healthy Cell Voltage Spectrum [22:13] Building EZ Water [23:12] Sunlight and UV Light Benefits [25:00] Additional EZ Water Builders [26:35] Mitochondrial Dysfunction [29:20] Apoptosis and Cell Function [30:41] Diseases Linked to Mitochondrial Dysfunction [31:44] Red Light Therapy (RLT) [32:23] Mechanisms of RLT [33:32] Anti-Inflammatory Properties of RLT [35:05] Cellular Benefits of RLT [35:32] Considerations for RLT Use [39:52] Closing Thoughts on RLT [40:33] Red Light vs. Near-Infrared Light [41:18] Red Light Therapy: More Is Not Better [43:13] Avoid Combining Red Light Therapy with Sauna [44:27] Enhancing Therapy with Methylene Blue [45:28] The Cycle of Mitochondrial Function or Dysfunction [47:47] Healthspan and Longevity - Save 20% when you purchase via The Mitochondrial Triad Bundle!Choose any one RLT device + one BioBlue supplement + one BioC60 supplement = save 20% on the entire order! No discount code necessary, click here to order! - Dr. Mike's #1 recommendations: Water products: Water & Wellness Grounding products: Earthing.com EMF-mitigating products: Somavedic Blue light-blocking glasses: Ra Optics - Stay up-to-date on social media: Dr. Mike Belkowski: Instagram LinkedIn BioLight: Website Instagram YouTube Facebook
Curious about the secret to staying young? Rob Signer shares insights into how our bodies age, focusing on the role of stem cells and a critical protein called HSF1 that helps them cope with stress. Signer explores the delicate balance of keeping these cells healthy without increasing cancer risk and highlighted some promising progress in enhancing the cells' ability to manage waste. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39980]
Curious about the secret to staying young? Rob Signer shares insights into how our bodies age, focusing on the role of stem cells and a critical protein called HSF1 that helps them cope with stress. Signer explores the delicate balance of keeping these cells healthy without increasing cancer risk and highlighted some promising progress in enhancing the cells' ability to manage waste. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39980]
Curious about the secret to staying young? Rob Signer shares insights into how our bodies age, focusing on the role of stem cells and a critical protein called HSF1 that helps them cope with stress. Signer explores the delicate balance of keeping these cells healthy without increasing cancer risk and highlighted some promising progress in enhancing the cells' ability to manage waste. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39980]
Curious about the secret to staying young? Rob Signer shares insights into how our bodies age, focusing on the role of stem cells and a critical protein called HSF1 that helps them cope with stress. Signer explores the delicate balance of keeping these cells healthy without increasing cancer risk and highlighted some promising progress in enhancing the cells' ability to manage waste. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39980]
Curious about the secret to staying young? Rob Signer shares insights into how our bodies age, focusing on the role of stem cells and a critical protein called HSF1 that helps them cope with stress. Signer explores the delicate balance of keeping these cells healthy without increasing cancer risk and highlighted some promising progress in enhancing the cells' ability to manage waste. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39980]
Curious about the secret to staying young? Rob Signer shares insights into how our bodies age, focusing on the role of stem cells and a critical protein called HSF1 that helps them cope with stress. Signer explores the delicate balance of keeping these cells healthy without increasing cancer risk and highlighted some promising progress in enhancing the cells' ability to manage waste. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39980]
Curious about the secret to staying young? Rob Signer shares insights into how our bodies age, focusing on the role of stem cells and a critical protein called HSF1 that helps them cope with stress. Signer explores the delicate balance of keeping these cells healthy without increasing cancer risk and highlighted some promising progress in enhancing the cells' ability to manage waste. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39980]
Curious about the secret to staying young? Rob Signer shares insights into how our bodies age, focusing on the role of stem cells and a critical protein called HSF1 that helps them cope with stress. Signer explores the delicate balance of keeping these cells healthy without increasing cancer risk and highlighted some promising progress in enhancing the cells' ability to manage waste. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39980]
Send us a textIn this episode of Taco Bout Fertility Tuesday, Dr. Mark Amols explores the hidden side of embryo development: cellular death. Why do some embryos that seem perfectly viable fail to implant? Dr. Amols breaks down the science behind apoptosis and necrosis, two types of cell death, and explains why some embryos may already be on the path to cellular death even before transfer. Learn about the challenges in detecting these processes and how cellular death can influence IVF outcomes. Whether you're undergoing fertility treatment or supporting someone who is, this episode sheds light on the reasons some embryos fail and offers comfort to those navigating the difficult emotions that come with it.Thanks for tuning in to another episode of 'Taco Bout Fertility Tuesday' with Dr. Mark Amols. If you found this episode insightful, please share it with friends and family who might benefit from our discussion. Remember, your feedback is invaluable to us – leave us a review on Apple Podcasts, Spotify, or your preferred listening platform. Stay connected with us for updates and fertility tips – follow us on Facebook. For more resources and information, visit our website at www.NewDirectionFertility.com. Have a question or a topic you'd like us to cover? We'd love to hear from you! Reach out to us at TBFT@NewDirectionFertility.com. Join us next Tuesday for more discussions on fertility, where we blend medical expertise with a touch of humor to make complex topics accessible and engaging. Until then, keep the conversation going and remember: understanding your fertility is a journey we're on together.
Larry joins Angie to discuss a question that came in concerning how sugar nutrients relate to cancer. Larry explains the nature of specific sugars and how they impact the immune system. He discusses the metabolic process of apoptosis which relies on sugars to enable the immune system to detect and eliminate cancer cells. Tune In!
Dr. Shoreh Ershadi is the founder of ANITAGING Institute of California and a renowned expert in clinical biochemistry and pharmacology with over 40 years of experience. Dr. Ershadi shares her compelling journey from Iran to the United States, highlighting her unexpected entry into medical technology and the numerous challenges she faced as a woman in science. From setting up clinical labs and pioneering AIDS testing to founding her own antiaging company, Dr. Ershadi discusses her relentless pursuit of scientific innovation and passion for improving human health. The conversation also touches on her entrepreneurial ventures, the role of art in her life, and her vision for a healthier future driven by natural apoptosis-promoting supplements. Guest links: www.Apoptosis.us | www.facebook.com/apoptosisnutraceuticals | www.instagram.com/apoptosisnutraceuticals | www.threads.com/apoptosisnutraceuticals Charity supported: Save the Children Interested in being a guest on the show or have feedback to share? Email us at podcast@velentium.com. PRODUCTION CREDITS Host: Lindsey Dinneen Editing: Marketing Wise Producer: Velentium EPISODE TRANSCRIPT Episode 037 - Dr. Shoreh Ershadi [00:00:00] Lindsey Dinneen: Hi, I'm Lindsey and I'm talking with MedTech industry leaders on how they change lives for a better world. [00:00:09] Diane Bouis: The inventions and technologies are fascinating and so are the people who work with them. [00:00:15] Frank Jaskulke: There was a period of time where I realized, fundamentally, my job was to go hang out with really smart people that are saving lives and then do work that would help them save more lives. [00:00:28] Diane Bouis: I got into the business to save lives and it is incredibly motivating to work with people who are in that same business, saving or improving lives. [00:00:38] Duane Mancini: What better industry than where I get to wake up every day and just save people's lives. [00:00:42] Lindsey Dinneen: These are extraordinary people doing extraordinary work, and this is The Leading Difference. Hello, and welcome back to another episode of The Leading Difference podcast. I'm your host, Lindsey, and today I'm so excited to introduce you to my guest, Dr. Shoreh Ershadi. With over 40 years of expertise in clinical biochemistry and pharmacology, Dr. Ershadi stands at the forefront of scientific innovation in the field of nutraceuticals and supplements. Board certified by the American Academy of Antiaging Medicine and holding dual doctorate degrees, Dr. Ershadi brings a wealth of knowledge and experience to the world. Dr. Ershadi's distinguished credentials, including National Registry in Clinical Chemistry and Toxicology and American Society of Clinical Pathology certifications, underscore her dedication to precision and quality in laboratory practices. Her visionary leadership and unwavering passion for advancing human health has made her a trusted authority in the field. All right. Well, Shoreh, thank you so much for being here today. I'm so excited to speak with you. [00:01:51] Dr. Shoreh Ershadi: Thank you for having me. I'm very excited to talk to you, especially that you're going to talk about medical technology. And that is something that I have been doing or working at for, I would say over 30 years, easy. 1988, I got my license in California. So it's what, 32 years? [00:02:17] Lindsey Dinneen: Yeah. Excellent. Oh my goodness. Well, this leads perfectly into my first question and that is, can you tell us a little bit about yourself and your background and how you got into medtech? [00:02:29] Dr. Shoreh Ershadi: Okay. That is interesting because I was born in Iran and I studied pharmacology. And before I was graduated, the Department of Health in Iran was hiring pharmacists, pharmacologists. So we all went and took the exam and we passed the exam. We were still at the final stages of doing the thesis and going through final stages of graduation. And then they called me and a few other people for an interview. Apparently I had a high mark in the test, which I did not know. So when we went for the interview, and I went to an American school and then later to a British school in Iran, so I was speaking English. At the interview, there was a gentleman who was back in Iran from United States, and he was a PhD in clinical biochemistry, and he asked me to read something in English. And I read it, and he thought that I had it by heart or something, so he flipped the book and found a more difficult page and said, "Okay, read this," and I read that, and he said, "Okay, I'm hiring you for the reference lab." I had absolutely no clue what he was talking about, what was reference lab. I had no intention to even work for Department of Health because I was not even graduated at that time. And then they said, "Okay, start on such and such date." And when I went there the first day, he said he spoke in English and he said, "You're overqualified." Oh my God. What? I mean, it was funny. Without even planning to get into laboratory, I got into the reference lab of Department of Health. And what he was planning to do was to bring College of American Pathologists, the proficiency testing to all the laboratories in Iran. And he wanted someone who would speak English and who could communicate. So first day of my job, I wrote a letter to College of American Pathologists and I said, "Hi, hello, I'm Shoreh Ershadi, I want to buy a thousand proficiency kits." And of course they responded. So just like that, I got into clinical laboratory. And I became the Director of the Quality Control for Department of Health. And that was before the revolution. So, that was my exciting start into laboratory. [00:05:25] Lindsey Dinneen: Yeah, that's an incredible story. Thank you for sharing that. And [00:05:28] Dr. Shoreh Ershadi: Not voluntarily, but serendipitously, yes. [00:05:34] Lindsey Dinneen: There you go. So then at some point, you came to the U. S. and was that transition really difficult? Was it frustrating? Were you excited? Nervous? [00:05:47] Dr. Shoreh Ershadi: There was a part in between before coming to U. S. There was another test by W. H. O., World Health Organization. So I took that test and I passed that test and I got a scholarship to go to medical school in England to do a master's degree. And when I went there, I told them, "I already have a doctorate in pharmacology. I don't want master's. I want to do PhD." And after a few weeks, they said, "Okay, fine, go to PhD. You don't need to do master." So I was in England for about four years. I did my PhD in clinical biochemistry. And I went back to Iran. That was exactly during the revolution. So while I was studying in England, the country in Iran was on fire. It was, things going crazy everywhere. But I went back and I got married. I had my son in Iran, and I was working in a clinical laboratory in one of the best hospitals in Iran, and it got very difficult for women to work. They were saying, " Now you have to wear a scarf. Now, you can't see male patients, you can only talk to female patients." It was not right. So, 1984, I came to United States, I came to California, and with some friends in Iran who had a clinical laboratory, and they were here before me and had started a lab in Orange County, California. I started a branch of the lab in Westwood, in Los Angeles. So that was my first job or position and that was my entrepreneurial side, which now I wouldn't dare to start a life, but then I did. [00:07:51] Lindsey Dinneen: You didn't know the difference then. [00:07:53] Dr. Shoreh Ershadi: Well, yes, I didn't know. I mean, it was a lot easier, I would say. At that point. The lab was not even accepting Medicare or Medi Cal. It was private insurance. I was doing the billing. I was getting the information. I was drawing the patients. I was separating the samples and sending them to the reference lab that was actually running the tests. But I was doing stat CBCs and I was in a medical building and so all the doctors were so nice to send the samples down to me. It worked. So [00:08:33] Lindsey Dinneen: Amazing. Oh my. [00:08:34] Dr. Shoreh Ershadi: Amazing. Yes. Now it sounds really amazing. It's surreal in a way. Yeah. [00:08:42] Lindsey Dinneen: Yeah. Yeah. Well, so, so with that lab and embracing this entrepreneurial journey, and I'm so thankful it worked out so well for you, but were there any moments where you just thought, okay, I've, I, you have such an amazing background. You're so highly educated, you're brilliant. And then you're starting this entrepreneurial journey, which is kind of a different skill set in a way. How was that transition of becoming kind of your own boss and being in charge of everything? [00:09:12] Dr. Shoreh Ershadi: That was pure ignorance. I mean, now I can say then, I thought I knew what I was doing, but it was a fast learning. First that I was in a different country, that I had never been in the United States. Second, that I had a three year old son that I brought with me and my then husband never came, so I got a divorce and I became a single mom. So, and nobody else was from my family was here. So it was very difficult because I had to take him to daycare and then come work and then go pick him up. And then there was a war, the Iraq war had started in Iran and my parents were in Iran and I was going through a divorce, so it was turmoil. And I had to work and learn in a way it was good because it didn't give me time to think about anything else. It was just forward, no looking sideways, no looking backwards. It was just moving forward. But then again, something else happened that made it even more interesting. One of the days that I was at the lab, some guy came and said, "CDL, Central Diagnostic Lab, is looking for a technical director and they've asked me to come and talk to you." I had absolutely no clue if anyone knew me or knew of me or it was the, I mean, a lot of things happened, which, I mean, I'm happy now, but then it changed my life tremendously. And I don't think I've ever talked to anyone about this in this detail. So, Lindsey, I would say you're the first person I'm telling the story of my life. But anyways, I went for an interview and I got hired right away. I had the lab, so I hired someone to do the work that I was doing in the lab. And then I started working at CDL, Central Diagnostic Labs, which was the largest privately owned lab in the United States at that time. There were 1, 200 employees. So that was a very interesting experience on its own because I was introduced to a world that I did not even know what was going on. So, and that was during AIDS testing. Bio-Rad had just come up with Western blot testing and we did the clinical trial, which was very easy in those days. We had AIDS patients and we had a lot of AIDS samples accumulated or saved frozen and we used them to validate the Western blot by Bio-Rad and I went on National TV 1988 and I said, "CDL is the first lab in the world that is doing a confirmation for HIV AIDS testing." So then, that was major. [00:12:40] Lindsey Dinneen: Yes. [00:12:43] Dr. Shoreh Ershadi: But then, then my family came. My father passed away here. It was, again, a lot of complications going on. And one of the other people that I knew asked me to go and partner with them in a lab. Again, my entrepreneurial part took over and I went for the partnership, and I started from scratch. I started Path Labs practically from scratch. There were two pathologists working with Los Alamitos Hospital, and I went there and I started a lab from just buying test tubes, buying, from absolutely nothing. I was there for six years, I think. six or eight years with Path Labs. That was not so successful. After that, I went to Specialty Labs, which is now Quest. Specialty wanted to start a toxicology lab. So, Path Lab was sold. But there was no money made with the partnership and all that. So that was not a very successful six, eight years of my life. Specialty was good. I went to Specialty and I started Department of Toxicology. I don't know if you remember or you were familiar with specialty. Dr. Peters was there and he was the founder, James Peters. He did only immunology testing. They would receive samples and send out everything else to other labs and only do the immunological tests or some specialty tests. When I started the toxicology department, we started getting samples from all over the world. We were running heavy metals and all that. We had an ICP MS and I started running ICP, and the main test that I developed there was measuring iron in the liver biopsy of patients with hemochromatosis. So we would get one spot, in tip of the needle of the liver and then do a measurement and measure the amount of toxicity with iron in hemochromatosis, which was great. I wrote a paper and we were working with Mayo Clinic and they developed the test. So that was very exciting. Then I started the automated lab because all the chemistry. And all the hematology was going out, was sent out. So that brought a lot of money into the lab, but that was not my lab. It was Dr. Peter's lab. It was wonderful. It was nice. But he was the entrepreneur there. So in the year 2000, I started ANTIAGING Institute of California. After passing the specialist chemist license in California, I got National Registry in Certified Chemistry, Certified Toxicology, and then I took the board exam with American Academy of Antiaging Medicine. And that was again entrepreneurial and I started the company, that would be 25 years ago. I've done a lot of consultation. I've been director of lab during COVID. I went back to city health. And I was Director of City Health running 4, 000 COVID patients a night for airports, for schools, for traveling, for a lot of stuff. And then I worked with Siemens Healthineers on regulations for IVDR. So all the kits that Siemens had, over 700 reagent kits that were sold to the laboratories, they need to get the CE mark to be able to be sold in Europe under the new IVDR regulations. And a lot of it had to go through FDA as well because FDA had to approve if there were any changes made to the kits. So I've done a lot of regulation works. I've done a lot of hands on COVID tests, covered it all. Actually, something else that was very interesting. And this, for MedTechs, I would think this would be interesting to know that it's not just one position. And there's so much you can do, if you want to expand your horizon. For about a year, I helped set up extremely high complex laboratory for testing mother's milk, for making milk bank from mother's milk for NICU for children who were born early and the formulas did not work with them. Some of them were so tiny, less than a pound. And so mother's milk bank, it's called Prolacta Bioscience, the company. And I worked there to establish the clinical lab and to get a license for clear and stuff like that. So. [00:18:21] Lindsey Dinneen: Oh! [00:18:21] Dr. Shoreh Ershadi: A lot of good work going into my up and down career, I would say. [00:18:28] Lindsey Dinneen: I love it. Well, first of all, I'm so honored that you were willing to share so much with me. That is. I really appreciate it. And I really appreciate you being willing to talk about some of the amazing moments you've had and the really high, " Yay, we did this," but also some of the moments where it was a little bit tougher and even you being honest and transparent about, the one company didn't do as well as you would have hoped, but you kept going and you are a living testament to resilience and adaptation. [00:18:59] Dr. Shoreh Ershadi: There is no other choice. I would hope that people would have many choices. I mean, you always make choices in life. Even now, this is a choice to talk to you and I appreciate the opportunity because, if I would choose or if I wouldn't know about you, that would be a totally different episode in my life. So I'm open to take chances. You can say that with my experience, living in three different continents and moving and just leaving Iran and coming to us with a three year old, not being here ever before. And then, just jumping in and, but there was no other choice except for moving forward, or we can say, except for success. Because failure was not an option. What would I do? There was nowhere to go back. Sometimes you may have an option to make a U turn and say, "Okay, I don't like this. I want to do something else. I want to stay home." There was no option, no going back. So it was only forward. [00:20:09] Lindsey Dinneen: Yes, absolutely. So, coming here and like you said, having to move forward and I appreciated what you said, you kind of, you couldn't look to the side, you couldn't look back. You had to keep moving forward. How did you go about building a community that could support you, that you could be friends with, and colleagues with, and feel supported coming in from, not having that. [00:20:36] Dr. Shoreh Ershadi: And that was not very difficult. There were many difficult times during that, that I mean, I don't mind talking about it, being a woman, being a young woman, being from a different background there was a lot of resistance. And I see that today as well. I mean, I can't say, "Oh, here I'm in L. A. and Los Angeles is so easy." It's not. I am hoping that women would not maybe experience all the difficulties that I went through. But we're talking about 40 years ago. I came to The States actually July 22nd would be exactly 40 years. I left Iran July 1st, 1984. So this is the 40th anniversary. Being a woman, I thought, when I went to England one of the first things, the professor was my direct supervisor when I worked with him. And I know you can see my face. This is 40 years later. I have no claims, but the professor told me, "You're a beautiful woman. Why do you want to study? Why are you here for PhD?" And I thought that was the greatest insult in my life. So I fought with that professor for four years. [00:22:15] Lindsey Dinneen: No, I'm sorry. [00:22:17] Dr. Shoreh Ershadi: That wasn't easy, but it was so difficult to prove that I am not just a woman or a pretty girl or a young girl or a young woman, or. That was a major fight. I would say that was as difficult as fighting the revolution in Iran, because you wouldn't expect a British professor to say that to you. And I was the only girl, a PhD student, all the others were guys, and this was medical school. And to me, that was very surprising because when I went to University of Tehran, we had probably more girls than guys in the class. Girls were very prone to education in Iran, and they still are. There's still, I think, 60, 65 percent girls in universities, even here. But to hear that was very difficult. That experience repeated itself. in United States over and over till today that I can say I don't feel old. I'm antiaging, but now that I'm an old woman, I still feel that I have to prove myself that I am equal. And sometimes I would say I'm better, but, just to be honest and modest, you want to be treated equal. And that is very difficult. [00:23:53] Lindsey Dinneen: Yeah. Yeah, you're absolutely right. And As much as I would wish things were improving rapidly, I'm not so sure that they are, but what have you found has been helpful in terms of, helping people understand who might come with a bias, but who, helping those people understand, "No I have this education. I am very capable." What are some strategies that you have found that have worked really well for you? [00:24:22] Dr. Shoreh Ershadi: Not many. I have to be honest with you. I mean, if there are a few people, few women, a few even men who are, would be following the conversation, I want them to know that this is not easy. And maybe a part of my success is that I'm a fighter. And I didn't surrender, but I didn't smile my way up. I fought with everyone that went in that direction. And I don't want to get into details, but many of the stronger men would think that if they flirt with you, if they take you out, if they buy dinner for you, then you're going to do what they say. And my story is, just, I have my guards up and I fought. I wouldn't recommend people to fight. Maybe they can find a better solution. I did not find many. Maybe the reason of working separate and starting my own company, maybe one of the major reasons was that I would not have to say yes to power that I did not want to say yes. I worked very hard. I worked hard, long hours. Medtechs, you have to stay there to get the results out. One Christmas. I stayed from December 24th for I would say 72 hours in the lab, maybe two, three hours shower and sleep and go back because we had a lot of toxicology tests that were waiting and results had to go out. And the probe in the I-C-P-M-S was broken. There was no one to replace it during Christmas. It was, we had to borrow from somewhere, FedEx shipping it. Those things happen, you know that, and you have to work hard. It wasn't an easy journey to say, "Oh, I worked four hours a day." And they said, "Thank you. You're so good. Go home." It wasn't like that. [00:26:44] Lindsey Dinneen: Right. Right. Yeah. Well, thank you. I appreciate you sharing that. And so one thing that was really interesting to me, I was looking at your LinkedIn profile and I see that art is a big part of your life in addition to the science and I saw you listed painting and sculpting and I'm wondering how-- well a couple of things-- how did you first get involved in art? And secondly, do you feel that is helpful in terms of having a sort of therapeutic thing to do that kind of maybe helps with some of those harder moments where it's a little frustrating? [00:27:23] Dr. Shoreh Ershadi: Very helpful. But I was as a kid, I started painting at a very young age. And I was always coloring and painting and making things and all that. And my father, a very educated father, he had two master's degree from a University of Texas and came back to Iran. And that's why, we spoke English and we went to English school. So my father was educated and open minded, I can say. But he always said that "You should study art. And don't go to medicine, you'll get old." He passed away in 1988, and I always, when I started Antiaging, I always said "Okay, if you're looking, you will see that I'm antiaging, I didn't age, I went to medical school, I did all the studies." But my logic, first that I love to do this, I mean, it wasn't just you know, forcing myself. I love science. And to this day I do a lot of research. I play with science. You can see the labels are all fancy. I do the paintings. I do all of that. But my logic, more than being scientific, was that this was a career and art would not be a self supporting career, even at younger age. But I always said that if I was a doctor, I could paint, but if I was an artist, I could not do the scientific part or the medical part that I was interested in. But after the divorce, I was in a relationship for 14 years. And I was working hard, raising a son, being a single mother and all that. When that relationship ended after 14 years, the art just popped out. I started painting, sculpting. It was not under control. You can see that, things happen to me, things come out in a certain period. Maybe, I push them down, force them to stay within me, and then they just pop out in different directions. So art came out itself. But there was a period in between that there was no art. Maybe there was too much stress. Maybe there was a lot of, and right now there's no art. Right now it's more entrepreneurial, starting, scientific, all that. But the art pops out every now and then. [00:30:07] Lindsey Dinneen: That's great. Yeah. So speaking of, what you're doing now, I was wondering if you could share a little bit about your company and maybe what you're excited about for its future as you continue along this path. [00:30:19] Dr. Shoreh Ershadi: Okay. That is, this is now where all the passion is. So everything that I have forced inside for all my life is now just coming out into Apoptosis. Apoptosis is a Greek word and it means "falling of the leaves." In science apoptosis, if you Google it, you'll see it means "programmed cell death." So in our bodies in creation or creator or whichever you wanna put it, and I'm sure being a medtech and all the audience, they know there are thousands of reactions inside the body are happening for me just to sit here and breathe and talk. There are thousands and thousands of enzymes and catalysts and metals and oh, whatever is going on. Programmed cell death or apoptosis is a main part of survival. So it's the future of antiaging because we all-- first of all that life expectancy is much longer now. Longevity is longer and younger people do not want to get old. So, at some point I would say my grandmother's generation and my mother is now 95 years old and she's, thank God, healthy and walking and all that, but even she does not want to get old. So, the image of being old and sick is combined together. But we can age without being sick, without getting Alzheimer's, without losing our memory, without getting all these different kinds of diseases. And one major problem is cancer that was much higher with older people and now the statistic is showing that cancer is happening in younger and younger generations. So what apoptosis does is that it's a program in the body. I did not make it. I wish I did, but it's happening all the time. And apoptosis is getting rid of cancer cells, getting rid of damaged cells, getting rid of neurons that cannot connect and synapses with other neurons to take the message over. So if we encourage apoptosis, then all the damaged cells are removed just like falling leaves. They're removed from the body and they're replaced with new energized healthy new cells. Every 10 years, our entire body is regenerated. So why do we get old? We should always stay at a 10 year age. So at 20 years old, we have recycled cells that even though we're growing, growth and youth is defined as between 20 to 25. From 25 to 30, it's sort of stable. There's a plateau. After 30, we start the aging process. So now, as 30 to 60, is still considered not so deep slip going down. It's sort of a plateau up to 60. And then after 60, 70, 80, 90, people are beginning to age. And it shows, I mean, with different diseases, with wrinkles, with memory loss, with all that. So what I'm doing, I'm using nature's product, plant based products, and this has been proven in science that these plants support apoptosis. So, as we get older, just like all the other reactions, apoptosis does not happen at its ultimate way that it should happen. But if we encourage it, for example, we have here, this one is brain beet. This is all beet roots, and it's an organic product. It's all plant based, but it releases nitric oxide. And it works the same way that Viagra works, but it opens all the arteries, it opens the circulation to the brain, to the heart, so why not use it? Why not promote apoptosis the way nature has programmed it in our body, just help it to work better. So that is all my passion right now. [00:35:28] Lindsey Dinneen: Excellent. Excellent. Well, I love that. Thank you for sharing a little bit about it. I'm excited for our listeners to go and learn more about it and, see how they can maybe also take part in the antiaging movement. [00:35:41] Dr. Shoreh Ershadi: Yes, they can partner with us and I would be thrilled. Actually, this is something that maybe I have learned during the long life experience, is that the more partners you have, the more friends you have, the more you share your knowledge, the better it is. Because at some point, it was like people wanted to keep everything to themselves and they didn't want to share or, but right now it's totally different. If they go to Apoptosis.us, they can go to the science section, they can read the papers. And if they would like to partner, I'll be thrilled to work with as many people as possible and take the message out. Yeah, this is a healthy message. This is something that we should all be talking about. [00:36:36] Lindsey Dinneen: Indeed, we should. Yes. Thank you. Well, pivoting the conversation just for fun, imagine that you were to be offered a million dollars to teach a master class on anything you want. It can be in your industry, but it doesn't have to be. What would you choose to teach? [00:36:56] Dr. Shoreh Ershadi: Well, the million dollar would be great. [00:36:59] Lindsey Dinneen: Indeed. [00:37:00] Dr. Shoreh Ershadi: Yes. Yeah. Would we all want that. But yes, I think that right now, as I said, I would use the million dollars to talk about apoptosis all over because I see even young children, every time I see St. Jude's children, and thank you for your donation to Save the Children. I admire that. And I'm hoping that all the children in the world would have a good, healthy future. The world is crazy. You can look at it right now and see that, I can say my experience has been crazy. It doesn't get any better. It's always up and down. Things are happening all over everywhere in the world. And I would like to talk about health, talk about antiaging, talk about Apoptosis and educate more and more of the young people to learn and to avoid all the toxins that we are creating and we have created, with what we're doing with industry and go back to a plant based life, go back to nature, enjoy nature, go back to art, if possible, all the good things that we can do with our lives. [00:38:21] Lindsey Dinneen: Yes, absolutely. And then, how do you wish to be remembered after you leave this world? [00:38:29] Dr. Shoreh Ershadi: Oh, wow. That's a very difficult... a fighter? Survivor? Yep. Strong women? I would support women all the way. Now in Iran, they're saying, Woman Life Freedom. I'm sure you've heard about that. And I cannot tolerate, to see women covered all over with a window to see outside. To me, that is very disturbing. So I would like to see equal opportunity for women and I would like to maybe be remembered as a survivor. [00:39:14] Lindsey Dinneen: Yes, absolutely. And then, final question, what is one thing that makes you smile every time you see or think about it? [00:39:24] Dr. Shoreh Ershadi: Oh, my granddaughter and my grandson. Yes, I have a five year old granddaughter. Her name is Julia and she is my sunshine. She is my life. The grandson is three months old. He's still too young, but he's getting there. [00:39:45] Lindsey Dinneen: Aw! [00:39:48] Dr. Shoreh Ershadi: Getting emotional. [00:39:51] Lindsey Dinneen: I'm so glad. It's that's beautiful. That's wonderful. [00:39:56] Dr. Shoreh Ershadi: Yes, that is continuation of the fight. That is when you see that what you've done is worth the fight, worth the hard work. [00:40:08] Lindsey Dinneen: Absolutely. Absolutely. Yes. Well, this has been amazing. I so appreciate you telling your story and sharing some of it that maybe you haven't done before, and that's I feel very honored. [00:40:23] Dr. Shoreh Ershadi: Yes. [00:40:24] Lindsey Dinneen: Thank you. Thank you for trusting me. [00:40:28] Dr. Shoreh Ershadi: Well, thank you for bringing all of this out. This has been sitting there suffocating, maybe. [00:40:36] Lindsey Dinneen: Yeah. [00:40:37] Dr. Shoreh Ershadi: Thank you. [00:40:38] Lindsey Dinneen: Absolutely. And we are so honored, you mentioned this, but to be making a donation on your behalf as a thank you for your time today to Save the Children, which works to end the cycle of poverty by ensuring communities have the resources to provide children with a healthy, educational, and safe environment. So thank you for choosing that organization to support. And we just wish you the most continued success as you work to change lives for a better world. [00:41:06] Dr. Shoreh Ershadi: Thank you so much, and thank you for having me, and thank you for making me tell the story. Thank you, Lindsey. [00:41:15] Lindsey Dinneen: Of course. And thank you also so much to our listeners for tuning in. And if you're feeling as inspired as I am right now, I would love if you would share this episode with a colleague or two, and we'll catch you next time. [00:41:29] Ben Trombold: The Leading Difference is brought to you by Velentium. Velentium is a full-service CDMO with 100% in-house capability to design, develop, and manufacture medical devices from class two wearables to class three active implantable medical devices. Velentium specializes in active implantables, leads, programmers, and accessories across a wide range of indications, such as neuromodulation, deep brain stimulation, cardiac management, and diabetes management. Velentium's core competencies include electrical, firmware, and mechanical design, mobile apps, embedded cybersecurity, human factors and usability, automated test systems, systems engineering, and contract manufacturing. Velentium works with clients worldwide, from startups seeking funding to established Fortune 100 companies. Visit velentium.com to explore your next step in medical device development.
Subscribe to our channel: https://www.youtube.com/@optispan Check out the Gurkar lab: http://agresearchlab.com/ In May 2024, Matt delivered a talk at the 2024 Glenn AFAR Grantee Conference in Santa Barbara, California and met with several people doing interesting work in the longevity field. One of these was Aditi Gurkar, an assistant professor in the University of Pittsburgh's Aging Institute, Division of Geriatric Medicine whose lab focuses on the downstream effects of DNA damage on aging. Prior to setting up her lab at the University of Pittsburgh, Aditi conducted research on the impact of DNA damage on aging at Scripps Research. She also completed postdoctoral training at Massachusetts General Hospital/Harvard Medical School and the Broad Institute of MIT and Harvard, where she focused on the tumor suppressor p53 as well as on autophagy regulation. Aditi received a PhD and a B.S. from the Boston University School of Medicine and Florida International University in Miami respectively. Matt and Aditi spend much of this episode chatting about senescent cells: how Aditi developed a focus on cellular senescence and found its relevance to aging, potential therapeutic benefits of senescent cell clearance, and the much-debated question of how to define a senescent cell. They also discuss the importance of "zooming out" from narrow areas of focus in the geroscience field to find new solutions and of breaking your own models on your way to productive new directions in science. Producers: Tara Mei, Nicholas Arapis Video Editor: Jacob Keliikoa DISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices. More places to find us: Twitter: https://twitter.com/optispanpodcast Twitter: https://twitter.com/optispan Twitter: https://twitter.com/mkaeberlein Linkedin: https://www.linkedin.com/company/optispan https://www.optispan.life/ Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it. On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!
LifeBlood: We talked about understanding apoptosis, how to grow older without aging, how our bodies are made up of over 30 trillion cells and how to cultivate their health, the role inflammation plays in our health, and how to be proactive about it, with Dr. Shoreh Ershadi Chief Medical Officer of Apoptosis Nutraceuticals, and Board Certified in AntiAging. Listen to how to begin improving your life and health spans! You can learn more about Shoreh at Apoptosis.US, and LinkedIn. Thanks, as always for listening! If you got some value and enjoyed the show, please leave us a review here: https://ratethispodcast.com/lifebloodpodcast You can learn more about us at LifeBlood.Live, Twitter, LinkedIn, Instagram, YouTube and Facebook or you'd like to be a guest on the show, contact us at contact@LifeBlood.Live. Stay up to date by getting our monthly updates. Want to say “Thanks!” You can buy us a cup of coffee. https://www.buymeacoffee.com/lifeblood
TWiV reviews viruses in the news: Chinese scientist who released the SARS-CoV-2 genome sequence sleeps in the street, a case of measles in Haifa, spread of waterborne infectious diseases in Gaza, interstate spread of avian influenza A(H5N1) in dairy cattle, and an orangutan heals himself with medicinal plants, followed by identification of a cell receptor for parechoviruses, and blockade of necroptosis prevents lung injury in severe influenza. Hosts: Vincent Racaniello, Dickson Despommier, and Alan Dove Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV (asv.org) The New City by Dickson Despommier (blog post) International Conference on Pandemic Preparedness Chinese virologist sleeps on street (Nature) Measles in Haifa (Jerusalem Post) Waterborne illness spreads in Gaza (Reuters) Interstate spread of H5N1 virus in dairy cattle (bioRxiv) Orangutan uses medicinal plants (Science) Parechovirus cell receptor identified (Nat Comm) Necroptosis blockade prevents lung injury in influenza (Nature) Necroptosis, pyroptosis and apoptosis (Cell Mol Immunol) Letters read on TWiV 1111 Timestamps by Jolene. Thanks! Weekly Picks Dickson – NASA's Webb Finds Ethanol, Other Icy Ingredients for Worlds Alan – MyClimate.org calculators Vincent – Twenty-Five Lectures in Virology 2024 Listener Picks Alan – NPR story and interactive quiz on pandemic respiratory disease transmission Az – H5N1 Avian Flu in Mammals Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Dive into the fascinating world of cellular aging and longevity with our guest expert, Dr. Greg Kelly. Dr Kelly is a fellow naturopathic physician & the vice president of product development at Qualia from Neurohacker Collective. From unraveling the mysteries of senescent cells to exploring cutting-edge regenerative medicine, we explore the intricate processes underlying aging and how they impact our health. Discover the role of stress, metabolism, and the immune system in the formation and clearance of senescent cells, and learn about the innovative work of Qualia by Neurohacker Collective. Tune in for a deep dive into the science of aging and practical insights for optimizing your cellular health. If you ALSO want to Resist aging at the cellular level, try Qualia Senolytic. Go to neurohacker.com/DRTYNA for up to $100 off and use code DRTYNA at checkout for an additional 15% off. On This Episode We Cover: 2:22 - Defining senescent cells 4:50 - The resources senescent cells use 6:46 - The causes of senescent cells & the hayflick limit 10:08 - Researching and tracking senescent cells in the body 14:59 - Stress on a cellular level & senescent cell accumulation 18:23 - Apoptosis & how to “detox” senescent cell 19:33 - Balancing autophagy 20:52 - Senescent cell prevention 23:33 - Types of cell death 26:21 - Quiescent cells 31:16 - Joint health & muscle tissue 34:50 - Senescent cells & organ transplantation 36:01 - Age reversal studies 38:53 - The microbiome and senescent cells 40:22 - The hallmarks of aging 41:36 - Polyphenols & alkaloids in the gut 43:34 - Senolytic supplements 46:23 - Hit & run dosing 52:29 - Other ways of preventing senescent cells 54:08 - Qualia pilot studies 58:40 - Qualia protocols 1:01:121- What to look out for while taking Qualia Disclaimer: Information provided in this podcast is for informational purposes only. This information is NOT intended as a substitute for the advice provided by your physician or other healthcare professional, or any information contained on or in any product. Do not use the information provided in this podcast for diagnosing or treating a health problem or disease, or prescribing medication or other treatment. Always speak with your physician or other healthcare professional before taking any medication or nutritional, herbal or other supplement, or using any treatment for a health problem. Information provided in this blog/podcast and the use of any products or services related to this podcast by you does not create a doctor-patient relationship between you and Dr. Tyna Moore. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent ANY disease.
In this insightful episode of The Women's Vibrancy Code, host Maraya Brown delves into the complex interplay between heart resonance, the power of energetic exchanges, and their impact on our life stages, from birth to death. With references to the works of Dr. Rewire and author Joseph Chilton Pearce, Maraya explores how our emotional state and stress levels can profoundly affect our connections with others, even before birth. This episode is a journey into understanding how the people and the energy we surround ourselves with influence our body's constant cycle of regeneration and healing. Episode Highlights: The Power of Heart Resonance: Discover how our heart's energy extends beyond our physical body and impacts those around us, with insights from Joseph Chilton Pearce's studies. The Science of Connectivity: Learn about the fascinating phenomenon where heart cells in proximity synchronize their beats, underscoring the importance of not being isolated. Birth and Death Dynamics: Maraya discusses her observations on how the presence of certain individuals can stall or facilitate crucial life transitions, highlighting the significance of vibrational energy in our most pivotal moments. The Role of Apoptosis in Everyday Life: This conversation sheds light on the ongoing process of cell death and regeneration within our bodies, emphasizing the importance of the energetic environment in which this occurs. Setting Boundaries for Energetic Health: Maraya encourages listeners to reflect on their relationships and the energy they allow into their lives, advocating for the establishment of boundaries to protect and enhance one's vibrational well-being. The Importance of Self-Care: Tying it all back to the necessity of self-care, Maraya urges the audience to prioritize their well-being through mindful practices and self-reflection. Maraya's conversation is not just an exploration of scientific concepts but a call to action for deeper self-awareness and intentional living. Tune in to this episode of The Women's Vibrancy Code for a transformative look at how we interact with the world around us and the profound effects those interactions have on our health and vitality. Download the Menstrual Tracker: Click here Download the Adaptogen Elixir Recipes: Click here Apply today for a free consult with Maraya to receive a personalized plan: Click here to apply Subscribe To The Women's Vibrancy Code: Women's Health And Wellness with Maraya Brown: Apple Podcast | YouTube | Spotify Connect With The Show: Facebook Page | Linkedin | Website | Tiktok | Facebook Group Make A Connection Call With Maraya Brown: Click here to book About Maraya Brown: Maraya is a Yale and Functional Medicine Trained Women's Health And Wellness Expert CNM, MSN with her undergraduate degree in marketing. She helps women feel turned on by their life, their lover and themselves. Her work online brings her 21 years of experience supporting women together in one place to co-create deep transformation, energy and passion. Maraya is the founder of this Podcast and does a great deal of work with women to expand their energy, hormones, libido, confidence and much much more. DISCLAIMER: The podcasts available on this website have been produced for informational, educational and entertainment purposes only. Listeners should take care to avoid program content which may not be suited to them. The contents of this podcast do not constitute medical or professional advice, No person listening to and/or viewing any podcast from this website should act or refrain from acting on the basis of the content of a podcast without first seeking appropriate professional advice and/or counseling, nor shall the information be used as a substitute for professional advice and/or counseling. The Women's Vibrancy Code Podcast expressly disclaims any and all liability relating to any actions taken or not taken based on any or all contents of this site. The Women's Vibrancy Code: Women's Health And Wellness w/ Maraya Brown
Please visit answersincme.com/PQD860 to participate, download slides and supporting materials, complete the post test, and obtain credit. In this activity, an expert in squamous cell carcinoma of the head and neck (SCCHN) discusses the clinical potential of antagonists of inhibitor of apoptosis proteins (IAPs) for unresected, locally advanced SCCHN. Upon completion of this activity, participants should be better able to: Identify the rationale for investigating the use of antagonists of inhibitor of apoptosis proteins (IAPs) in the treatment of unresected locally advanced squamous cell carcinoma of the head and neck (LA SCCHN); Discuss the latest efficacy and safety data for emerging IAP antagonists for the treatment of unresected LA SCCHN; and Outline clinical considerations for future use of IAP antagonists in unresected LA SCCHN.
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TWiV explains how immune profiling was used to identify distinguishing features of Long COVID, and how a co-opted feline endogenous retroviral envelope promotes cell survival by controlling copper transport and homeostasis in cats. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Spike shirts at vaccinated.us (promo code Microbetv) Research assistant position in Rosenfeld Lab CBER/FDA (pdf) Features of Long COVID (Nature) ERV envelope mediates feline copper homeostasis (Cell Rep) Letters read on TWiV 1049 Timestamps by Jolene. Thanks! Weekly Picks Brianne – Webb spots a building block of life on Jupiter's moon Europa Rich – Are we really made of ‘star stuff?' Learn about your body's elements Alan – Avian flu has reached the Galàpagos Vincent – Why the US can't have nice things Listener Pick Az – Free solo Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Hi Everyone! Hope you enjoy this final installment in the cell biology series where we discuss cell death, focusing on non-lytic cell death represented by apoptosis. As always, please rate and share the show and I'll see you back for the metabolism series coming soon!
Enter the fascinating world of cell death, where nosy neighbors can tell each other to “die, already” … and cells can wake up one day and realize there's something very, very wrong. Also learn how cancer manipulates the conscientious cells to make them blissfully unaware of their own wrongdoing … or holds them hostage while they desperately, desperately try to do the right thing and kill themselves for the good of everyone. It's a glimpse into a world where cells seem sentient, and one could almost start to believe in miracles. Links Mentioned in Today's Show: Article on apoptosis: https://www.dogcancer.com/articles/stats-and-facts/apoptosis/ Curcumin: https://www.dogcancer.com/articles/supplements/curcumin-for-dogs/ Apocaps supplement: https://Apocaps.com Related Links: Supplements that have apoptogens: https://www.dogcancer.com/podcast/supplements/supplements-for-dogs-with-cancer-dr-demian-dressler-deep-dive/ Apoptosis and dietary apoptogens: https://www.dogcancer.com/podcast/supplements/apoptosis-and-how-dietary-apoptogens-help/ Article on how to reduce cancer risk using food: https://www.dogcancer.com/articles/causes-and-prevention/how-to-reduce-cancer-risk-using-food/ Chapters: 00:00 Start 04:08 Apoptosis 101 10:22 Training T-cells 14:31 How Cells Die 18:17 Cancer Cells Defy Apoptosis 23:17 Using Apoptosis for Cancer Treatment 25:02 Apoptogens Induce Apoptosis 29:54 Dietary Apoptogens -- Get to know today's guest, Amanda Kin, M.S.: https://www.dogcancer.com/people/amanda-kin-bs-ms/ For more details, articles, podcast episodes, and quality education, go to the episode page: https://www.dogcancer.com/podcast/ Learn more about your ad choices. Visit megaphone.fm/adchoices
Blurb In this posdcast Dr. Luigi Rolli, Dr. Chiara Ciniselli, Dr. Paola Perego and Dr. Giulia Bertolini discuss the biological role of the antimetastatic gene KiSS1 based on the results they obtained in Non Small Cell Lung Cancer cellular models and in liquid biopsies obtained from patients and healthy subject
References JBC.2002. Volume 277, ISSUE 2, P1128-1138. Cancer Discov. 2022 Mar 1; 12(3): 856–871. Guerra lectures-lipid metabolic regulation Guerra lectures-pharmacodynamics and kinetics --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message
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Some people have been wearing diapers to the shows, maybe even this weekend's in Detroit, too. Plus, this house in Ohio has some CRAZY art on the inside! AND, first beer of the weekend with Apoptosis!
Please visit answersincme.com/EEF860 to participate, download slides and supporting materials, complete the post test, and obtain credit. In this activity, an expert in head and neck squamous cell carcinoma (HNSCC) discusses the clinical significance of emerging antagonists of inhibitors of apoptosis proteins (IAPs) for patients with HNSCC. Upon completion of this activity, participants should be better able to: Describe the biologic rationale for emerging antagonists of IAPs for patients with resectable and unresectable locally advanced (LA) HNSCC; Review the clinical significance of emerging antagonists of IAPs in the treatment of unresectable LA HNSCC, based on the latest efficacy and safety data; and Outline strategies for how antagonists of IAPs may fit into future treatment algorithms for patients with resectable and unresectable LA HNSCC, as they become available.
References Cell Death & Differentiation 2020.27: 3374–3385 Cell Death & Differentiation 2019. 26: 1501–1515 Cancers 2020, 12(8), 2137. --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message Support this podcast: https://anchor.fm/dr-daniel-j-guerra/support
A new research paper was published in Oncotarget's Volume 13 on December 17, 2022, entitled, “The role of pyrethroid derivatives in autophagy and apoptosis crosstalk signaling and potential risk for malignancies.” Pyrethroids are extensively used insecticides by virtue of insecticidal activity potential in Asia, especially India, and in different nations worldwide to counter mosquitoes and insects for household or agricultural needs. The continuous widespread and uncontrolled use of pyrethroids and its derivatives have influenced multiple deleterious effects resulting in a potential risk factor causing damage to organ systems. Allethrin and prallethrin are extensively used, yet their influences on human primary cells are very limited or under-reported. The potential mechanisms by which allethrin and prallethrin modulates human primary cells, especially the molecular mechanisms or interconnectivity of autophagy-apoptosis, their clinical relevance in human subjects or patients are not well defined. In the current study, researchers Jyothi Puvula, Narendra Maddu, Nagajothi Gutam, Asha Parimal, and Raghavendra B. Pongali from Sri Krishnadevaraya University, Queen Mary's College, Manipal University, and National Institute of Biomedical Genomics furnished the evidence that both allethrin and prallethrin user samples significantly induced Ccl2 mRNA expression, increased amount of reactive oxygen intermediate, inhibited membrane bound enzymes and altered membrane fluidity. Pyrethroid derivative users had induced levels of lipid peroxidation and induced binding activities of transcription factors(tfs) like CEBP-β and NF-AT. Pyrethroid derivatives induced autophagy, elicited intracellular Ca2+ concentration, calcineurin and regulated proapoptotic genes, DAPK1, Bim. “Our current study presumably comprises the initial investigation of a very new mechanism of pyrethroid derivatives-moderated programmed cell death in various cell sets or types, like human primary cells where-in this is a late event, is documented.” Hence, the current research study might be significant in the various pyrethroid derivatives-allied hematological-related cancers and immunosuppressant or auto-immune disorders. In the foremost instance, the researchers present data stating that pyrethroid derivatives induces multiple cell signaling cascades, like CEBP-β, NF-AT, ERK and MAPK having a role in autophagy thereby; synchronously effectively impact on the apoptosis, therefore causing hematological tumors and toxic or immune related disorders. “Overall this current study might facilitate to formulate therapeutics or intervention targets that might serve to decrease the effect or impact of pyrethroids derivatives by targeting the signaling cascade that serves to minimize the modulation of autophagy mediated apoptosis.” DOI: https://doi.org/10.18632/oncotarget.28328 Correspondence to: Raghavendra B. Pongali - raghavbiot@gmail.com Keywords: allethrin, prallethrin, autophagy, apoptosis, Ccl2 About Oncotarget: Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. To learn more about Oncotarget, visit Oncotarget.com and connect with us on social media: Twitter - https://twitter.com/Oncotarget Facebook - https://www.facebook.com/Oncotarget YouTube – www.youtube.com/c/OncotargetYouTube Instagram - https://www.instagram.com/oncotargetjrnl/ LinkedIn - https://www.linkedin.com/company/oncotarget/ Pinterest - https://www.pinterest.com/oncotarget/ LabTube - https://www.labtube.tv/channel/MTY5OA SoundCloud - https://soundcloud.com/oncotarget For media inquiries, please contact: media@impactjournals.com.
Have you heard about Apoptosis? Are you aware of this very important function that happens in our bodies at the very cellular level, and the impact it has on your health? Apoptosis is a form of programmed cell death that occurs naturally in our bodies. It helps keep our cells healthy and functioning, allowing them to live longer and work more efficiently. When apoptosis isn't working properly, it can cause serious health problems, such as cancer and other diseases. Most people don't know this, but at the cellular level of our body, there is something called the rule of the 3 Rs. What are the 3 Rs? REPAIR REPLACE REJUVENATE. These are all a result of proper apoptosis. But what's more important to know is how to support the process so that it works even better. Today I'm going to discuss three things about apoptosis and its importance in self-care. It might sound complicated at first, but it's really not that difficult to understand when you think about it. And besides, you don't need to be an expert on how it works in order for it still take place effectively within your own body! I found supplements to help support apoptosis in my body. It is plant-based and the only product I have found that does not give me side effects. Key Takeaways-What is apoptosis?-How apoptosis impacts one's health-How can one support apoptosis to be functioning for optimal health-Cell death, particularly apoptosis, is probably one of the most widely-studied subjects among cell biologists
Value: After Hours is a podcast about value investing, Fintwit, and all things finance and investment by investors Tobias Carlisle, Bill Brewster and Jake Taylor. See our latest episodes at https://acquirersmultiple.com/ About Jake: Jake is a partner at Farnam Street. Jake's website: http://farnam-street.com/vah Jake's podcast: https://twitter.com/5_GQs Jake's Twitter: https://twitter.com/farnamjake1 Jake's book: The Rebel Allocator https://amzn.to/2sgip3l About Bill: Bill runs Sullimar Capital Group, a family investment firm. Bill's website: https://sullimarcapital.group/ Bill's Twitter: @BillBrewsterSCG ABOUT THE PODCAST Hi, I'm Tobias Carlisle. I launched The Acquirers Podcast to discuss the process of finding undervalued stocks, deep value investing, hedge funds, activism, buyouts, and special situations. We uncover the tactics and strategies for finding good investments, managing risk, dealing with bad luck, and maximizing success. SEE LATEST EPISODES https://acquirersmultiple.com/podcast/ SEE OUR FREE DEEP VALUE STOCK SCREENER https://acquirersmultiple.com/screener/ FOLLOW TOBIAS Website: https://acquirersmultiple.com/ Firm: https://acquirersfunds.com/ Twitter: https://twitter.com/Greenbackd LinkedIn: https://www.linkedin.com/in/tobycarlisle Facebook: https://www.facebook.com/tobiascarlisle Instagram: https://www.instagram.com/tobias_carlisle ABOUT TOBIAS CARLISLE Tobias Carlisle is the founder of The Acquirer's Multiple®, and Acquirers Funds®. He is best known as the author of the #1 new release in Amazon's Business and Finance The Acquirer's Multiple: How the Billionaire Contrarians of Deep Value Beat the Market, the Amazon best-sellers Deep Value: Why Activists Investors and Other Contrarians Battle for Control of Losing Corporations (2014) (https://amzn.to/2VwvAGF), Quantitative Value: A Practitioner's Guide to Automating Intelligent Investment and Eliminating Behavioral Errors (2012) (https://amzn.to/2SDDxrN), and Concentrated Investing: Strategies of the World's Greatest Concentrated Value Investors (2016) (https://amzn.to/2SEEjVn). He has extensive experience in investment management, business valuation, public company corporate governance, and corporate law. Prior to founding the forerunner to Acquirers Funds in 2010, Tobias was an analyst at an activist hedge fund, general counsel of a company listed on the Australian Stock Exchange, and a corporate advisory lawyer. As a lawyer specializing in mergers and acquisitions he has advised on transactions across a variety of industries in the United States, the United Kingdom, China, Australia, Singapore, Bermuda, Papua New Guinea, New Zealand, and Guam.
Listen to Zuopeng Wang gave his presentation of "Rapamycin Induces Autophagy And Apoptosis In Kaposiform Hemangioendothelioma Primary Cells In Vitro" at the first ever Best of the Best in Pediatric Surgery event.
References Immunity 2022 551370-1385.e8DOI: (10.1016/j.immuni.2022.06.007 J Biol Chem. 2016 Nov 25; 291(48): 24986–25003. J of Visualized Experiments. 2013; (81): 50966 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message
References Dr Guerra Tumor lectures Nature Reviews Endocrinology 2020.volume 16, pages224–233 J Neurochem. 2006 Nov;99(4):1237-50. doi: 10.1111/j.1471-4159 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message
Regain your freedom from Crohn's, ulcerative colitis, constipation and more in 12 weeks or less without harmful drugs or surgeries. To book a free call and to learn more about working with Dr. Christine, visit: www.bit.ly/gutcall To purchase Dr. Christine's custom formulations: www.OmegaDigestion.com
Timestamps: (links below) 01. 00:00:00 Welcome back / Show road map / Guest introductions 02. 00:06:36 Nation Wars #7 03. 00:14:32 5.0.9 PTR Patch 04. 00:18:57 Thoughts on the patch 05. 00:28:18 How are Protoss mains taking the changes? 06. 00:39:39 Discussing the Queen nerf 07. 00:59:42 What do you think should be changed? 08. 01:23:26 Patreon Q&A 09. 01:23:59 What crazy things would you like to see in the next patch? 10. 01:24:48 Thoughts on changing forcefields? 11. 01:30:04 Final thoughts / Wrap up 12. 01:31:02 Thanks for watching #NW7 - https://www.ulule.com/nationwarssc2/ - Updates - https://twitter.com/NationWarsSC2 - Support Ukraine: https://linktr.ee/RazomForUkraine - World Discussions with Neuro: - https://www.youtube.com/watch?v=Spw1lH1qxbg - https://www.youtube.com/watch?v=00587Tc77Ts #ThePylonShow #StarCraft #StarCraft2 #CobraVe7nom7 #Apoptosis808 The Pylon Show Ep.#152
Local beeks on national stage, Apivar losing its punch, bees and social distancing, spring tasks, Tepache, Apoptosis, and Mead Part 2. Local Hive report, Closing Comments
Local beeks on national stage, Apivar losing its punch, bees and social distancing, spring tasks, Tepache, Apoptosis, and Mead Part 2. Local Hive report, Closing Comments
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