Podcasts about cell stress

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.19.549693v1?rss=1 Authors: Zhu, S., Waeckel-Enee, E., Moser, A., Bessard, M.-A., Roger, K., Lipecka, J., Yilmaz, A., Bertocci, B., Diana, J., Saintpierre, B., Guerrera, I. C., Francesconi, S., Mauvais, F.-X., van Endert, P. Abstract: Appropriate tuning of protein homeostasis through mobilization of the unfolded protein response (UPR) is key to the capacity of pancreatic beta cells to cope with highly variable demand for insulin synthesis. An efficient UPR ensures a sufficient beta cell mass and secretory output but can also affect beta cell resilience to autoimmune aggression. The factors regulating protein homeostasis in the face of metabolic and immune challenges are insufficiently understood. We examined beta cell adaptation to stress in mice deficient for insulin-degrading enzyme (IDE), a ubiquitous protease with high affinity for insulin and genetic association with type 2 diabetes. IDE deficiency induced a low-level UPR in both C57BL/6 and autoimmune non-obese diabetic (NOD) mice, associated with rapamycin-sensitive beta cell proliferation strongly enhanced by proteotoxic stress. Moreover, in NOD mice, IDE deficiency protected from spontaneous diabetes and triggered an additional independent pathway, conditional on the presence of islet inflammation but inhibited by proteotoxic stress, highlighted by strong upregulation of regenerating islet-derived protein 2, a protein attenuating autoimmune inflammation. Our findings establish a key role of IDE in islet cell protein homeostasis, identify a link between low-level UPR and proliferation, and reveal an UPR-independent anti-inflammatory islet cell response uncovered in the absence of IDE of potential interest in autoimmune diabetes. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.06.547951v1?rss=1 Authors: Cloots, E., Guilbert, P., Provost, M., Neidhardt, L., Van de Velde, E., Fayazpour, F., De Sutter, D., Savvides, S. N., Eyckerman, S., Janssens, S. Abstract: As secretory cells specialized in the production of mucins, intestinal goblet cells are challenged by the need for efficient protein folding. Goblet cells express Inositol-Requiring Enzyme 1{beta} (IRE1{beta}), a unique unfolded protein response (UPR) sensor that is part of an adaptive mechanism that regulates the demands of mucin production and secretion. However, how IRE1{beta} activity is tuned to mucus folding load remains unknown. We identified the disulfide isomerase and mucin chaperone AGR2 as a goblet cell specific protein that crucially regulates IRE1{beta}-, but not IRE1-mediated signaling. AGR2 binding to IRE1{beta} disrupts IRE1{beta} dimerization, thereby blocking its downstream endonuclease activity. Depletion of endogenous AGR2 from goblet cells induces spontaneous IRE1{beta} activation, suggesting that alterations in AGR2 availability in the endoplasmic reticulum sets the threshold for IRE1{beta} activation. We found that AGR2 mutants lacking their catalytic cysteine or displaying the disease-associated mutation H117Y were no longer able to dampen IRE1{beta} activity. Collectively, these results demonstrate that AGR2 is a central chaperone regulating the goblet cell UPR by acting as a rheostat of IRE1{beta} endonuclease activity. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

All chronic illnesses can be traced back to the same root causes. Learn about stealth microbes and cell stress and how these contribute to chronic illnesses of all kinds. Dr. Bill Rawls goes over the root causes of chronic illness and the tools he has found most effective for healing. Dr. Rawls's Bio: As a 4th-generation physician, Bill Rawls, MD has dedicated his life to medicine. But when faced with a personal health crisis in his late forties with Lyme disease, everything changed. In his quest to regain his health, Dr. Rawls was confronted with the limitations of conventional medicine and knew he had to find his own path to restore wellness. For the past 15 years, he has extensively studied the science behind herbal therapies and new sustainable approaches for protecting health. Today, Dr. Rawls shares the revelations that helped him and thousands of others reclaim their lives. Dr. Rawls is a leading expert in integrative health and Medical Director of Vital Plan, a holistic health and herbal supplement company in Raleigh, NC. He is the best-selling author of Unlocking Lyme, and his most recent book, The Cellular Wellness Solution: Tap Into Your Full Health Potential with the Science-Backed Power of Herbs. Book Titles: The Cellular Wellness Solution Unlocking Lyme Products: https://vitalplan.sjv.io/QORqV3 Social Media: Instagram: https://www.instagram.com/vitalplan/ Facebook: https://www.facebook.com/VitalPlan Twitter: https://twitter.com/VitalPlan YouTube: https://www.youtube.com/channel/UCRv4ZKm24n7Ospxwo2OLiFw ____________________________________________ Find more resources like applying, social media, and recommended products here: ⁠https://linktr.ee/gutfarmacist --- Support this podcast: https://podcasters.spotify.com/pod/show/gutfarmacist/support

On Scripps College Week:  How do our cells respond to stress? Today on The Academic Minute: Gretchen Edwalds-Gilbert, associate professor of biology, takes a closer look. Gretchen Edwalds-Gilbert is an Associate Professor of Biology at Claremont McKenna, Pitzer, and Scripps Colleges in California. She completed her Ph.D. at the Weill Cornell Medical College and did […]

Arnold Kriegstein, MD, PhD presents his paper as published in the January 29, 2020 issue of Nature Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 35457]

Arnold Kriegstein, MD, PhD presents his paper as published in the January 29, 2020 issue of Nature Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 35457]

Arnold Kriegstein, MD, PhD presents his paper as published in the January 29, 2020 issue of Nature Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 35457]

Arnold Kriegstein, MD, PhD presents his paper as published in the January 29, 2020 issue of Nature Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 35457]

Arnold Kriegstein, MD, PhD presents his paper as published in the January 29, 2020 issue of Nature Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 35457]

Arnold Kriegstein, MD, PhD presents his paper as published in the January 29, 2020 issue of Nature Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 35457]

Arnold Kriegstein, MD, PhD presents his paper as published in the January 29, 2020 issue of Nature Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 35457]

Arnold Kriegstein, MD, PhD presents his paper as published in the January 29, 2020 issue of Nature Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 35457]

How do cells respond to stress? In this episode Dr Matt & Dr Mike discuss hypertrophy, hyperplasia, atrophy, and metaplasia!

Alzheimer’s disease is one of the most severe neurodegenerative diseases among elderly people. Different pathogenic factors for Alzheimer’s disease have been posited and studied in recent decades, but no effective treatment has been found, necessitating further studies. In this Viewpoint article, we assess studies on the mechanisms underlying the accumulation of amyloid (Aβ) peptide and the formation of Aβ oligomers because their accumulation in amyloid plaques in brain tissue has become a well-studied hallmark of Alzheimer’s disease. We focus on the production of Aβ and its impact on the function of synapses and neural circuits, and also discuss the clinical prospects for amyloid-targeted therapies. Zhou Y, Sun Y, Ma QH, Liu Y. Alzheimer's disease: amyloid-based pathogenesis and potential therapies. Cell Stress. 2018;2(7):150–161. Published 2018 Jun 29. doi:10.15698/cst2018.07.143. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged. Sections of the Abstract, Introduction, The Amyloid Cascade Hypothesis and Subsequent Studies, and Conclusion are presented in the Podcast. Link to the full-text article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6551797/

Subscribe via iTunes PhD Micah Zuhl Micah is a professor at Central Michigan University and he shares his research and experience. GI Distress & Glutamine Supplementation He has published research on GI distress during intense training.  His studies have found that doses of glutamine can help prevent leaky gut and reduce the likelihood of GI distress. The oral doses used in his study were .9g per kg of fat free mass (lean body mass) per day, spread out over three doses, for a period of 7 days.  His studies on the topic were published in the Journal of Applied Physiology (Jan 15, 2014) and also Cell Stress & Chaperones (July 26, 2014). Note that their may be side effects of glutamine use. Pregnant and breast feeding women may want to avoid supplementation. WebMd list potential side effects here.  As with any supplement, take responsibility for your decisions and do proper research and consultation with your doctor in advance. High Intensity Training We also discussed the benefits of high intensity interval training. He wrote an article on the topic which is available here. Heat Acclimation Finally, we briefly discussed benefits of heat acclimation for improved performance during all conditions, not just hot conditions. Subscribe via iTunes

In addition to mediating the transcriptional response to hypoxia, HIF-1α also inhibits proliferation under oxygen-limiting conditions.

Oxidative stress induces separation of the catalytic and regulatory portions of the yeast 26S proteasome, enabling the catalytic core to degrade toxic oxidized proteins.