Podcasts about Enzyme

Large biological molecule that acts as a catalyst

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Latest podcast episodes about Enzyme

Essential Ingredients Podcast
06: Beyond Relaxation: Michael Stusser and Heather Bishop Dive Deep on Enzyme Baths, Zen Gardens, and Trust Ownership

Essential Ingredients Podcast

Play Episode Listen Later Aug 25, 2026 47:41


"We are so well positioned to have it continue and flourish because we have become a Perpetual Purpose Trust, which means this place is no longer owned by one person or any financial interest—it is owned by purpose." —Michael Stusser "We're always trying to figure out how we keep moving the property forward in a way that's sustainable, and also how it's going to impact our guests, our business, our staff." —Heather Bishop  A perpetual purpose trust sounds like a legal footnote until you meet the two people who actually built one. This episode traces how Osmosis Day Spa Sanctuary in Sonoma County became the first U.S. spa to place itself inside that structure — permanently removing any future owner's ability to chase profit over mission.  Justine first sits down with founder Michael Stusser, who traces the idea back to a single afternoon in an 800-year-old Kyoto stone garden, and then with CEO Heather Bishop, who inherited the vision and had to figure out how to make it legally unbreakable. This one's for anyone who's tired of the word "sustainable" doing all the talking and none of the work. Michael and Heather don't just describe the enzyme bath, the meditation gardens, or the gray water system — they explain the budgeting, the permits, and the trade-offs behind each one. It's a conversation about what it actually costs, in time and humility, to build something that outlasts you. The enzyme bath's heat comes entirely from billions of thermophilic bacteria fermenting Douglas fir and rice bran — not from any external heat source. Osmosis's perpetual purpose trust means the business has no human shareholder; its "shareholder" is the mission itself, enforced by a trust committee and an independent trust enforcer. The five-and-a-half-acre property couldn't legally go into the same trust as the business, so it's being paid off and moved into a separate land trust over the next three to five years. A gray water system currently covers roughly 50–60% of the property's irrigation needs, with a rainwater catchment system planned to close the gap entirely. Osmosis sources its enzyme bath wood shavings as a byproduct from local lumber operations that would otherwise throw them away. Trust-based decision-making already changed real policy — Heather cites expanding paid time off to all staff, including part-time employees, as a direct result of the trust's staff-benefit objectives. Listen to the full conversation with Michael Stusser and Heather Bishop, and follow Essential Ingredients so you don't miss what's next. https://tinyurl.com/Essential-Ingredients-Podcast  Meet Michael:   Michael Stusser, founder of Osmosis Day Spa Sanctuary, is a pioneer in ecological sustainability, organic gardening, and holistic wellness. Beginning his journey at UC Santa Cruz in the late 1960s, he helped establish horticultural training centers and later served on the board of the Farallones Institute in Sonoma County.  In the early 1980s, Michael apprenticed in traditional landscape gardening in Kyoto, Japan, where he immersed himself in Zen meditation and discovered the healing power of cedar enzyme baths. Returning to California in 1984, he introduced this unique practice, gaining national recognition in outlets like The New York Times and CNN. By 1988, he transformed five acres in Freestone into Osmosis, blending inspired landscaping, meditation traditions, and eco‑restoration to create a sanctuary rooted in sustainability, spirituality, and rejuvenation.  LinkedIn Meet Heather:  Heather Bishop is the CEO of Osmosis Day Spa Sanctuary, where she leads one of Northern California's most distinctive hospitality businesses with a focus on people‑centered leadership and operational excellence. Over the past decade, she has guided Osmosis through transformative organizational change, overseeing operations, finance, HR, strategic planning, and guest experience for a team of 80+.  Heather recently spearheaded the company's transition into a Purpose Trust‑owned business—one of the few in the United States—ensuring long‑term mission preservation while modernizing governance, HR systems, and employee benefits. With expertise in executive leadership, organizational development, change management, and hospitality operations, Heather is dedicated to building resilient, purpose‑driven organizations where employees thrive and guests enjoy exceptional experiences.  LinkedIn Connect with Osmosis:  Website Instagram Facebook  X YouTube Pinterest Connect with NextGen Purpose: Website Facebook Instagram LinkedIn YouTube Podcast Chapters: 01:48 Meet Michael Stusser: The Kyoto Garden That Started It All 03:11 What Is an Enzyme Bath, Really? 09:51 Osmosis Becomes a Perpetual Purpose Trust 13:03 Self-Love, Deep Peace: Osmosis's Core Mission 16:38 Meet Heather Bishop: Massage Therapist to CEO 19:40 Stewarding Salmon Creek and the Meditation Gardens 27:17 Inside the Cedar Enzyme Bath's Sustainable Sourcing 30:28 Perpetual Purpose Trust, Explained in Plain Terms 36:03 Why the Land Stayed Out of the Trust 39:30 What Sustainability Actually Costs  THE PRIMES  ✨ You're more capable than you have ever been, and somehow more invisible than ever. You keep handing out advice you do not take yourself. You keep saying 'after this next thing' to your own life, and the people around you have no idea because, from the outside, everything looks fine— that is exactly what The Primes was built for.

Pints & Polishing...an Auto Detailing Podcast
Mold in a Porsche, Ceramic Coating High Spots, and Using Chemicals Properly. Episode #968

Pints & Polishing...an Auto Detailing Podcast

Play Episode Listen Later Aug 25, 2026 59:30


Mold in a Porsche. High spots on a fresh ceramic. And the one mistake that keeps detailers from getting real protection on the car.Marshall and Nick pull back the curtain on the kind of problems shop owners and serious enthusiasts run into every day - from dealing with mold remediation in modern vehicles to the exact reason coatings fail when people try to stretch product too far. If you've ever wondered whether you're using enough on the pad, enough on the panel, or enough on the process, this episode is going to hit home fast.Marshall also breaks down the real-world value of giving customers a path, not just a product - from maintenance kits to YouTube guidance to a complete ecosystem that helps shops protect cars and keep customers coming back. Nick adds the practical side of why some jobs should be left to the dealership, why overthinking tools can slow you down, and why “light usage” often just means not enough product on the surface.Then the conversation shifts to the bigger picture: Juice, Sliq , Spray Coat, Stack, and Eco One. What's the difference, when should you use each one, and how do dilution ratios and application style change the result? If you've ever second-guessed whether you're spraying enough, wiping enough, or mixing enough, this one clears it up.Essential listening for detailers, shop owners, and car lovers who want better results, fewer mistakes, and a simpler system that actually works.Chapter timestamps00:00 - Why sitting in a moldy car makes you rethink your whole day01:13 - Enzyme cleaning mold and why masks matter02:11 - Pulling mats, frunk talk, and when to replace instead of save04:25 - Why removing seats on modern cars is an insurance problem05:16 - Old-school flood-and-extract methods versus modern remediation07:56 - Dodge truck jokes and why truck owners get so defensive10:36 - Uno questions and the rule of loading the applicator thick12:19 - Why underapplying coating causes flashing and missed coverage15:54 - Why protection only works if you actually use enough of it17:14 - How Stack, Uno, Trey, and Sparta get used panel by panel19:19 - What a high spot is and why it is mostly just ugly21:39 - Nathan's customer gets a full maintenance path, not just a coating23:34 - Turning YouTube and the Facebook group into a product encyclopedia26:15 - Why shops can cut their cost in half by building kits into every job28:08 - Coating a new Traverse RS and the right order for trim, glass, and paint30:50 - Which detailing lights are worth buying and which ones are overhyped33:40 - Whether glass needs polishing before coating35:24 - How to fix a high spot with VLO, Lux, or a towel method38:56 - Looking back and forward while you coat so you do not miss anything43:46 - Juice versus Slick versus Spray Coat versus Stack48:46 - Why product cost should not make you underapply50:23 - Why Nick does not like using rinseless or waterless on interiors55:10 - Eco One dilution ratios and how the 5-gallon cube works59:05 - Closing thoughts and the value of the HyperClean Specialists group

Mind & Matter
Endocannabinoid Biology in Health & Disease | Nephi Stella | Episode 305

Mind & Matter

Play Episode Listen Later Aug 20, 2026 100:40


Send us Fan MailThe biology of endogenous cannabinoids & history of cannabinoid-based therapeuticsTOPICS DISCUSSED:Anandamide vs 2-AG: The two major endocannabinoids with a shared arachidonic acid backbone but distinct head groups biological roles.On-demand production: Calcium-dependent enzymes release cannabinoids from membranes in response to neuronal activity patterns.Trafficking: Fatty acid binding proteins and extracellular microvesicles traffic endocannabinoids within and between cells.Adolescent THC: Global receptor activation during circuit wiring may contribute to cannabis use disorder and psychosis vulnerability in susceptible individuals.Enzyme inhibitors: Early FAAH clinical trial halted by off-target toxicity; MAGL inhibitors advancing in phase 2 for anxiety and addiction.Peripheral CB1: Liver receptors regulate metabolism; restricted antagonists aim to reduce weight without central psychiatric risks of the weight loss drug rimonabant.ABOUT THE GUEST: Nephi Stella, PhD is a professor at the University of Washington School of Medicine. He has studied endocannabinoid signaling for more than 25 years, focusing on therapeutic strategies that separate beneficial effects from side effects of cannabinoid-system modulation.Support the showSupport my work:Good Chemistry: Personalized, science-based health consulting. Work with Dr. Nick Jikomes directly.Affiliate Partners: Visit this link to see my affiliate partners and get discounts codes for products & services to support health.For all the ways you can support my efforts.

Health Nerds
Sodbrennen: Das Paradox von zu viel oder zu wenig Magensäure

Health Nerds

Play Episode Listen Later Aug 20, 2026 32:44 Transcription Available


„Sodbrennen kann entstehen, obwohl wir zu wenig Magensäure haben. Das klingt paradox, ist biologisch aber erklärbar.“ Das Brennen hinter dem Brustbein scheint eindeutig: Säure steigt aus dem Magen in die Speiseröhre, also muss der Körper zu viel davon produzieren. Doch Reflux bedeutet zunächst nur, dass Mageninhalt in die falsche Richtung fließt. Entscheidend ist deshalb nicht allein, wie viel Magensäure vorhanden ist, sondern warum der Mageninhalt überhaupt zurückfließt. Dahinter können eine übermäßige Säureproduktion, eine gestörte Magenbeweglichkeit, ein schwacher Schließmechanismus zwischen Magen und Speiseröhre oder unter bestimmten Bedingungen sogar zu wenig Magensäure stecken. In dieser Folge der artgerecht HEALTH NERDS erklären Podcast-Host Felix Moese und Gesundheitswissenschaftler Matthias Baum, warum Magensäure für eine funktionierende Verdauung unverzichtbar ist. Mit einem pH-Wert um 1 herrscht im Magen ein extrem saures Milieu. Es denaturiert Nahrungsproteine, aktiviert das eiweißspaltende Enzym Pepsin, hilft dabei, Mikronährstoffe aus der Nahrung verfügbar zu machen, und bildet eine wichtige Barriere gegen unerwünschte Keime. Wird zu wenig Säure produziert, kann deshalb auch die Verdauung selbst aus dem Takt geraten. Felix und Matthias zeigen, wie Mahlzeitengröße, spätes Essen, Übergewicht, Alkohol, Stress, bestimmte Lebensmittel oder eine Hiatushernie Reflux begünstigen können. Auch Säureblocker werden differenziert eingeordnet: Protonenpumpenhemmer können bei entsprechender medizinischer Indikation sinnvoll sein und die Säurebelastung deutlich reduzieren. Werden sie jedoch eingesetzt, ohne die Ursache der Beschwerden zu kennen, kann das Symptom verschwinden, während das zugrunde liegende Problem bestehen bleibt. Gleichzeitig verändert eine langfristig reduzierte Magensäure das Milieu im Verdauungstrakt und kann die Aufnahme bestimmter Nährstoffe beeinflussen. Wer immer wieder unter Sodbrennen leidet, sollte deshalb genauer hinschauen: auf Portionsgrößen und Essenszeiten, individuelle Trigger, Stress und die Abläufe der eigenen Verdauung. Bitterstoffe vor dem Essen können dabei ebenso eine Rolle spielen wie bewusstes, langsames Essen und ausreichend Abstand zwischen der letzten Mahlzeit und dem Schlafengehen. Bei häufigen oder starken Beschwerden, Schluckproblemen, Erbrechen oder unerklärlichem Gewichtsverlust ist eine ärztliche Abklärung wichtig. Denn Magensäure ist nicht das Problem, das wir grundsätzlich bekämpfen müssen. Wir brauchen sie. Entscheidend ist, dass sie in der richtigen Menge produziert wird und dort bleibt, wo sie ihre Arbeit machen soll. HEALTH NERDS. Mensch, einfach erklärt. Spare 15% auf Deine erste Bestellung auf https://artgerecht.com mit dem Code: HEALTHNERDS15 (im Warenkorb eingeben) Ein ALL EARS ON YOU Original Podcast.

The Darin Olien Show
Food Is Information: What Every Bite Is Really Telling Your Body

The Darin Olien Show

Play Episode Listen Later Aug 13, 2026 23:25


What if food is doing far more than providing calories, protein, carbohydrates, and fat? What if every bite is actually delivering information to your genes, cells, microbiome, and biological systems? In this fascinating solo episode, Darin challenges the century-old idea of viewing food simply as fuel and explores what happens when we begin seeing food as biological information. From carrots resembling eyes and walnuts resembling brains to nutrigenomics, plant compounds, biophotons, structured water, living enzymes, and the microbiome, Darin dives into the hidden layers of food that never appear on a nutrition label. He explores established research alongside emerging and controversial areas of science, explaining why the freshness, color, diversity, and wholeness of what we eat may matter far beyond its calorie count. Darin also reveals why "eating the rainbow" is really about consuming a wider library of chemical information and why feeding your gut microbes may be just as important as feeding yourself. This episode will completely change the way you look at what's sitting on your plate. What You'll Learn Why Darin believes the calorie model leaves out some of food's most important biological effects How nutrients and plant compounds can influence gene expression through nutrigenomics and epigenetics Why Darin describes every meal as sending a "memo" to your DNA What biophotons are and the emerging research around light emitted by living cells and foods Why fresh, living foods may carry information that heavily processed foods have lost The theory of structured or "exclusion zone" water in living foods What happens to naturally occurring enzymes when foods are heated and processed Why the colors of fruits and vegetables correspond to different families of protective plant compounds How your food communicates with the trillions of microbes living inside your gut Why dietary diversity and fermented foods may help create a healthier, more resilient microbiome Chapters 00:00:00 – Welcome to SuperLife 00:00:32 – Sponsor: Bite 00:02:47 – The hidden clues sitting inside your food 00:03:22 – Carrots, tomatoes, and walnuts: coincidence or clues? 00:04:13 – Why we've been too busy counting calories 00:04:39 – Food is information 00:04:47 – Why the calorie model leaves out the bigger picture 00:05:14 – Your body isn't a furnace 00:05:48 – How food communicates with your cells 00:06:25 – Nutrigenomics: how food talks to your genes 00:06:53 – Every meal can influence gene expression 00:07:22 – What memo are you sending your DNA? 00:07:52 – The strange science of biophotons 00:09:03 – Why fresh food emits different light than processed food 00:09:37 – Where biophoton research stands scientifically 00:10:26 – Structured water and the fourth phase of water 00:12:00 – What processing may do to water inside food 00:12:37 – Sponsor: Manna Vitality 00:14:35 – The controversial theory of food enzymes 00:15:18 – What we know about enzymes in raw and sprouted foods 00:15:37 – The hidden information missing from nutrition labels 00:15:58 – Can the color of your food unlock your potential? 00:16:16 – Why "eat the rainbow" is chemistry, not mysticism 00:16:38 – Anthocyanins and the power of purple, red, and blue foods 00:17:27 – Color is the plant's natural label 00:18:20 – Every color sends your body a different message 00:18:50 – The problem with the modern "beige diet" 00:19:14 – You're feeding 38 trillion microbes, not just yourself 00:19:46 – How gut bacteria transform fiber into powerful compounds 00:20:25 – The extraordinary conversation between plants and your microbiome 00:21:05 – Why plant diversity matters for immunity, mood, and hormones 00:21:31 – The Stanford fermented food study 00:22:02 – What fermented foods did to microbiome diversity and inflammation 00:22:30 – Ultra-processed food, inflammation, and what's coming next 00:22:45 – Continue the full deep dive on Patreon 00:23:24 – Closing thoughts Thank You to Our Sponsors Bite Toothpaste: Go to trybite.com/DARIN20 or use code DARIN20 for 20% off your first order Manna Vitality: Go to mannavitality.com/ and use code DARIN12 for 12% off your order. Join the SuperLife Patreon: This is where Darin now shares the deeper work: - weekly voice notes - ingredient trackers - wellness challenges - extended conversations - community accountability - sovereignty practices Join now for only $7.49/month at https://patreon.com/darinolien Find More from Darin Olien: Website: darinolien.com Instagram: @darinolien Book: Fatal Conveniences Platform & Products: superlife.com New Show: Roadmap to Happiness Key Takeaway "Food isn't just fuel. Every bite carries information—through nutrients, plant compounds, color, fiber, enzymes, and the interactions it creates with your microbiome. Your body isn't simply counting calories; it's responding to biological signals. So the question isn't only how much you're eating. It's what message you're sending your body every time you sit down to eat." Bibliography/Sources: Food as Information & Nutrigenomics Dutton, R. (2017). Hey, Hippocrates: Food isn't medicine. It's just food. STAT News . https://www.statnews.com/2017/04/10/hippocrates-food-medicine/ Genes and diet in the prevention of chronic diseases in future generations. (n.d.). PubMed Central . https://pmc.ncbi.nlm.nih.gov/articles/PMC8900696/ Müller, M., et al. (2026). Nutrigenomics and the interface between diet and gene expression. ScienceDirect . https://www.sciencedirect.com/ Nutriepigenomics. (n.d.). In Wikipedia . https://en.wikipedia.org/wiki/Nutriepigenomics Stover, P. J., & Garza, C. (n.d.). Food as exposure: Nutritional epigenetics and the new metabolism. PubMed Central . https://pmc.ncbi.nlm.nih.gov/articles/PMC6486241/ Biophotons & Structured Water Bio-photons: The light in your cells, food & water. (n.d.). Watermatters . https://www.yourwatermatters.com/ Biophotons may shed new light on body and brain activity. (2025). Psychology Today . https://www.psychologytoday.com/ Pollack Laboratory. (n.d.). University of Washington. https://pollacklab.org/ Pollack, G. H. (2013). The fourth phase of water: Beyond solid, liquid, and vapor. Ebner & Sons Publishers . The legacy of light: Fritz-Albert Popp and the biomedical power of biophotons. (n.d.). Dr. Clark Store . https://drclarkstore.com/ Enzymes, Sprouting & Traditional Diets Characteristics of traditional diets. (n.d.). The Weston A. Price Foundation . https://www.westonaprice.org/ Edward Howell, MD. (n.d.). The Weston A. Price Foundation . https://www.westonaprice.org/ Germination: An alternative source to promote phytonutrients in edible seeds. (n.d.). Food Quality and Safety . https://academic.oup.com/fqs Howell, E. (1985). Enzyme nutrition: The food enzyme concept. Avery . Nutritional and end-use perspectives of sprouted grains: A comprehensive review. (2021). Food Science & Nutrition . https://onlinelibrary.wiley.com/doi/full/10.1002/fsn3.2477 Price, W. A. (1939). Nutrition and physical degeneration. Price-Pottenger Nutrition Foundation . Study on effect of germination on flavonoid content and nutritional value of different varieties of chickpeas. (2024). PubMed Central . https://pmc.ncbi.nlm.nih.gov/articles/PMC10787121/ Phytonutrients & Colors Anthocyanidins and anthocyanins: Colored pigments as food, pharmaceutical ingredients, and the potential health benefits. (2017). Food & Nutrition Research . https://pmc.ncbi.nlm.nih.gov/articles/PMC5613902/ Anthocyanins as key phytochemicals acting for the prevention of metabolic diseases. (n.d.). PubMed Central . https://pmc.ncbi.nlm.nih.gov/articles/PMC6489379/ The therapeutic potential of anthocyanins: Current approaches based on their molecular mechanism of action. (2020). Frontiers in Pharmacology . https://www.frontiersin.org/articles/10.3389/fphar.2020.01300/full Microbiome, Fiber & Fermented Foods From dietary fiber to host physiology: Short-chain fatty acids as key bacterial metabolites. (2016). Cell . https://www.cell.com/cell/fulltext/S0092-8674(16)30559-6 Stanford Medicine. (2021, July). Fermented-food diet increases microbiome diversity, decreases inflammatory proteins, study finds . https://med.stanford.edu/news/all-news/2021/07/fermented-food-diet-increases-microbiome-diversity-lowers-inflammation The mutual effect of dietary fiber and polyphenol on gut microbiota. (2025). ScienceDirect . https://www.sciencedirect.com/ Shape, Biomimicry & Botanical History Cardenas, D. (2013). Let not thy food be confused with thy medicine: The Hippocratic misquotation. e-SPEN Journal . https://doi.org/10.1016/j.clnme.2013.10.002 How do the 'three sister' plants work together? (n.d.). Soils Matter . https://soilsmatter.wordpress.com/ Kimmerer, R. W. (2013). Braiding sweetgrass: Indigenous wisdom, scientific knowledge, and the teachings of plants. Milkweed Editions . Nutritional benefits of lycopene and beta-carotene: A comprehensive overview. (n.d.). PubMed Central . https://pmc.ncbi.nlm.nih.gov/articles/PMC9317578/ The six tastes in Ayurveda: How rasa creates true satisfaction. (n.d.). Art of Living Retreat Center . https://artoflivingretreatcenter.org/ Three sisters farming: A model of regenerative agriculture. (n.d.). One Earth . https://www.oneearth.org/ Ultra-Processed Food & Meat Research Cleveland Clinic. (2018). Cleveland Clinic studies reveal role of red meat in gut bacteria, heart disease development . https://newsroom.clevelandclinic.org/ Hall, K. D., et al. (2019). Ultra-processed diets cause excess calorie intake and weight gain: An inpatient randomized controlled trial of ad libitum food intake. Cell Metabolism . https://doi.org/10.1016/j.cmet.2019.05.008 Harvard T.H. Chan School of Public Health. (2015). WHO report says eating processed meat is carcinogenic . https://www.hsph.harvard.edu/nutritionsource/2015/11/03/report-says-eating-processed-meat-is-carcinogenic-understanding-the-findings/ International Agency for Research on Cancer. (2015, October). Carcinogenicity of the consumption of red meat and processed meat. IARC Monographs Volume 114 . https://publications.iarc.fr/ The detrimental impact of ultra-processed foods on the human gut microbiome and gut barrier. (2025). Nutrients . https://www.mdpi.com/2072-6643/17/1 Ultra-processed foods and food additives in gut health and disease. (2024). Nature Reviews Gastroenterology & Hepatology . https://www.nature.com/articles/s41575-024-00898-3 Ultra-processed foods, gut microbiota, and inflammatory bowel disease: A critical review of emerging evidence. (2025). PubMed . https://pubmed.ncbi.nlm.nih.gov/

The Dairy Nutrition Blackbelt Podcast
Dr. Mike Van Amburgh: What is Limiting Milk Components? | Ep. 147

The Dairy Nutrition Blackbelt Podcast

Play Episode Listen Later Aug 13, 2026 12:55


In this episode of The Dairy Nutrition Blackbelt Podcast, Dr. Mike Van Amburgh, Professor at Cornell University, explores what truly limits milk components in modern dairy cows. He discusses the roles of amino acids and fatty acids in milk fat synthesis, the biological factors contributing to increasing milk fat levels, and the nutritional considerations affecting milk protein production. Listen now on all major platforms."The way requirements are evaluated needs to move beyond net nitrogen and consider the metabolic machinery needed to make milk fat and protein."Meet the guest: Dr. Mike Van Amburgh is a Professor at Cornell University with long-standing expertise in dairy cattle nutrition, animal science, and the Cornell Net Carbohydrate and Protein System. He earned his Ph.D. in Animal Science from Cornell University and his B.S. in Dairy Science from The Ohio State University. Hear more from Dr. Mike Van Amburgh on The Dairy Nutrition Blackbelt Podcast, available on all major platforms.Liked this one? Don't stop now — Here's what we think you'll love!Victoria Ramos: Fatty Acids in Dairy Cow Diets | Ep. 103Dr. Eduardo Rico: Omega-3 & Inflammation Control | Ep. 128What will you learn: (00:00) Highlight(01:47) Introduction(02:27) Milk fat gains(03:47) Amino acid responses(05:20) Fat synthesis(07:08) Enzyme requirements(10:30) Protein response(13:22) Closing thoughtsThe Dairy Nutrition Blackbelt Podcast is trusted and supported by the innovative companies:- Virtus Nutrition* Vetagro* Barentz* Fortiva* Kemin* Priority IAC* Adisseo- DietForge- Esmilco Inc.

Science Friday
The evolution of an enzyme engineer who changed chemistry

Science Friday

Play Episode Listen Later Aug 3, 2026 30:07


In nature, enzymes are the catalysts that make much of biology work. They jumpstart chemical reactions that either wouldn't happen, or would happen super slowly. They break down food, build other molecules, extract energy, and more. What if we could harness evolution to engineer designer enzymes that do other specific jobs that benefit us?  Putting that idea into practice changed the game for chemistry, and earned Frances Arnold the Nobel Prize prize in 2018. She called it “directed evolution.” Today, thousands of labs use her methods to coax enzymes into doing things no one ever thought of. She joined Host Flora Lichtman in March 2026 to talk about where she sees this approach going in the future, and the personal evolution that brought her into science. Guest:  Dr. Frances Arnold is the Linus Pauling Professor of Chemical Engineering, Bioengineering and Biochemistry at the California Institute of Technology in Pasadena, California. Other episodes you may enjoy: Enzymes Are Taking On Our Plastic Problem Even Nobel Prize Winners Deal With Imposter Syndrome The transcript for this episode is available at sciencefriday.com. Subscribe to this podcast. Follow our show on Instagram, TikTok, Facebook, and Bluesky @scifri and sign up for our newsletters. Got a science question that's keeping you up at night? Call us: 877-472-4374 Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Ask Doctor Dawn
Peptide FDA Review and Gray-Market Contamination, CRISPR enzyme as a Cancer Kill Switch, and Testosterone's Paradoxical Role in Advanced Prostate Cancer

Ask Doctor Dawn

Play Episode Listen Later Aug 1, 2026 51:50


>p>Broadcast from KSQD, Santa Cruz on 7-30-2026: A type of coffee brewed from beans that have been altered by passage through the digestive track of civet cats is a delicacy in Southeast Asia. A Scientific Reports paper using gas chromatography analyzed Kopi Luwak (civet-processed coffee beans) versus fresh-picked beans, finding elevated caprylic and capric acids that carry the characteristic flavor notes found in dairy products. Dr. Manuel Esteller sampled and tested the blood, saliva, urine, and stool of the oldest human Maria Branyas Morera, who died last year at 117. Despite exceptionally short telomeres, she carried anti-inflammatory genetic variants seen in long-lived dogs, worms, and flies, and had unusually high Bifidobacterium levels—likely boosted by her three-daily-servings-of-yogurt habit. Dr. Dawn defends sunscreen use against Environmental Working Group scare campaigns, noting that concerns about absorption of sunscreen ingredients into blood remain theoretical while sunburn's melanoma link is well-established. She argues that a badly sunburned toddler starts a clock that can produce melanoma by the late teens. The FDA advisory committee is reviewing certain short amino acid chains popularly known as "peptides" for potential compounding-pharmacy production, covering proposed to treat ulcerative colitis, wound healing, insomnia, insulin resistance, migraines, and osteoporosis. Dr. Dawn flags that five to seven committee members have industry conflicts of interest, but argues that even flawed approval is preferable to the current gray market, where analysis shows vials contain only 4-28% of labeled content along with endotoxin and toluene contamination. She proposes surveillance tracking of prescribed peptides to catch adverse effects early, citing a foreign melanocortin nasal spray tanning product that caused rare nasal melanomas as a cautionary example. Utah State biochemists working with the Cas12a2 CRISPR enzyme discovered that instead of behaving as a precise gene-editor like Cas9, it goes into an indiscriminate DNA-shredding mode after recognizing its target RNA. By programming it to recognize RNA sequences uniquely activated in cancer cells (embryonic-development genes that shouldn't be running in adults), researchers destroyed only the cancer cells in tissue culture, potentially offering a way to eliminate small metastases without healthy tissue toxicity. Cancer patients who received a COVID-19 mRNA vaccine within 100 days of starting immune checkpoint inhibitor therapy showed dramatically improved outcomes, with median survival in advanced lung cancer rising from 20 to 37 months. Non-mRNA vaccines (flu, pneumonia) showed no such benefit. Lab work suggests the mRNA triggers type-1 interferon release that activates tumor-infiltrating immune cells and drives them to lymph nodes to train other immune cells against the tumor. Researchers redesigned a CD40 agonist antibody to bind multiple receptors simultaneously by clustering with a second antibody, stretching the cell surface and triggering a powerful immune response. In a 12-patient trial, injecting one tumor caused all tumors to shrink in six patients and produced complete remission in two—including a melanoma patient with dozens of leg tumors and a metastatic breast cancer patient whose lung and liver tumors resolved after skin injection. Two small trials of CAR natural killer cells—engineered like CAR T-cells but derived from donor umbilical cord blood and thus potentially available off-the-shelf—showed remarkable results in autoimmune disease. All 27 systemic lupus patients targeting the CD19 protein on autoantibody-producing cells showed improvement, with some remaining in remission at nearly two years. A single Shanghai patient with systemic sclerosis showed restoration of normal skin and blood vessel structure. A paradox has emerged in advanced prostate cancer: while blocking testosterone halts early tumor growth, cancer cells eventually adapt to low-androgen conditions such that flooding tissues with testosterone in advanced disease can actually halt tumor progression by triggering cellular redifferentiation. Separately, Dr. Dawn reviews conflicting evidence on Parkinson's risk from androgen deprivation therapy, singling out enzalutamide (Xtandi) as the most concerning drug due to blood-brain barrier penetration, and recommending darolutamide as the safest alternative with matching prostate efficacy but minimal CNS entry.

AUF1
Von der Natur inspiriert: Wie Ananas, Papaya und das Ei den Darm heilen können!

AUF1

Play Episode Listen Later Jul 24, 2026 32:37


Ein gesunder Darm ist der Grundpfeiler für eine optimale Gesundheit des Menschen. Doch was benötigt der Darm wirklich, um gesund zu sein? Geht es allein um das Mikrobiom oder spielen auch Enzyme eine entscheidende Rolle? Insbesondere stellt sich die Frage, welche Wirkung Enzyme auf die Schleimhaut haben und wie sie dazu beitragen, den sogenannten "Leaky Gut" zu schließen.

Elevator Pitches, Company Presentations & Financial Results from Publicly Listed European Companies
BRAIN Biotech Elevator Pitch | Enzyme, Biotechnologie und Wachstumsstrategie

Elevator Pitches, Company Presentations & Financial Results from Publicly Listed European Companies

Play Episode Listen Later Jul 8, 2026 8:25


In diesem seat11a Elevator Pitch stellt Michael Schneiders, CFO der BRAIN Biotech AG, das Geschäftsmodell, die Technologieplattform und die langfristige Wachstumsstrategie des Unternehmens vor.BRAIN Biotech ist ein Unternehmen der industriellen Biotechnologie und entwickelt Enzyme, Mikroorganismen sowie biologische Lösungen für Kunden aus den Bereichen Lebensmittel, Getränke, Life Sciences sowie weiteren Spezialmärkten. Mit seinen Produkten unterstützt das Unternehmen die Biologisierung industrieller Prozesse und den Übergang zu nachhaltigeren Produktionsverfahren.Das Geschäftsmodell basiert auf zwei komplementären Säulen. BRAINBiocatalysts bündelt das operative Geschäft mit Spezialenzymen, Mikroorganismen sowie Forschungs-, Entwicklungs- und Produktionsdienstleistungen. BRAINBioIncubator konzentriert sich auf innovative Entwicklungsprojekte, Beteiligungen sowie Lizenz- und Royalty-Modelle mit zusätzlichem Wertschöpfungspotenzial.Im Geschäftsjahr 2024/25 erzielte BRAIN Biotech einen Umsatz von rund 45,4 Mio. Euro, ein bereinigtes EBITDA von rund 4,4 Mio. Euro sowie wiederkehrende Erlöse von rund 4,2 Mio. Euro. Damit verbindet das Unternehmen ein profitables operatives Geschäft mit langfristigen Innovationsprojekten.Im Rahmen des Capital Markets Day 2024 stellte BRAIN Biotech ambitionierte mittelfristige Ziele vor. Für den Bereich BRAINBiocatalysts strebt das Unternehmen einen Umsatz von 100 Mio. Euro sowie eine bereinigte EBITDA-Marge von 15 % an. Ergänzend soll die erfolgreiche Kommerzialisierung von Projekten aus dem BRAINBioIncubator zusätzliche Wertschöpfung schaffen.Langfristig verfolgt BRAIN Biotech das Ziel, zu den Top 10 der weltweit führenden Spezialenzymunternehmen aufzusteigen und von den strukturellen Wachstumstrends in den Bereichen industrielle Biotechnologie, Spezialenzyme und nachhaltige biologische Lösungen zu profitieren. ▶️ Other videos:Elevator Pitch: https://seat11a.com/investor-relations-elevator-pitch/Company Presentation: https://seat11a.com/investor-relations-company-presentation/Deep Dive Presentation: https://seat11a.com/investor-relations-deep-dive/Financial Results Presentation: https://seat11a.com/investor-relations-financial-results/ESG Presentation: https://seat11a.com/investor-relations-esg/T&CThis publication is for informational purposes only and does not constitute investment advice. Using this website, you agree to our terms and conditions outlined on www.seat11a.com/legal and www.seat11a.com/imprint.

Health Nerds
Warum wir uns aufgebläht fühlen: Exokrine Pankreasinsuffizienz

Health Nerds

Play Episode Listen Later Jul 2, 2026 31:22 Transcription Available


„Verdauung ist kein passiver Vorgang. Sie ist Hochleistungsbiologie und gehört zu den komplexesten Prozessen unseres Körpers.“ Jede Mahlzeit setzt ein fein abgestimmtes Zusammenspiel von Magen, Leber, Galle, Bauchspeicheldrüse und Darm in Gang. Funktioniert eines dieser Organe nicht mehr richtig, gerät der gesamte Verdauungsprozess aus dem Gleichgewicht. Genau das passiert bei einer exokrinen Pankreasinsuffizienz: Die Bauchspeicheldrüse produziert nicht mehr genügend Verdauungsenzyme. Nahrung wird nur unvollständig aufgespalten und wichtige Nährstoffe können schlechter aufgenommen werden. In dieser Folge der artgerecht HEALTH NERDS erklären Podcast-Host Felix Moese und Gesundheitswissenschaftler Matthias Baum, warum Verdauungsbeschwerden nicht automatisch ein Darmproblem sind und weshalb die Bauchspeicheldrüse in der Diagnostik häufig übersehen wird. Sie erläutern, wie Verdauungsenzyme arbeiten, weshalb Beschwerden wie Blähbauch, Fettstuhl oder Nährstoffmängel entstehen können und warum chronischer Stress, Entzündungen oder Veränderungen im Darmmilieu die Funktion der Bauchspeicheldrüse zusätzlich beeinträchtigen können. Außerdem geht es um moderne Diagnoseverfahren wie die Bestimmung der Pankreaselastase im Stuhl, um aktuelle Therapiemöglichkeiten mit Verdauungsenzymen und um die Frage, warum Verdauung bereits im Gehirn beginnt. Matthias Baum erklärt, weshalb unser Nervensystem den gesamten Verdauungsprozess steuert und warum oft nicht nur entscheidend ist, was wir essen, sondern auch wie wir essen. HEALTH NERDS. Mensch, einfach erklärt. Spare 15% auf Deine erste Bestellung auf https://artgerecht.com mit dem Code: HEALTHNERDS15 (im Warenkorb eingeben) Ein ALL EARS ON YOU Original Podcast.

Vital Health Download
Radio Show / Podcast – June 28, 2026

Vital Health Download

Play Episode Listen Later Jun 28, 2026 59:43


Hosts: Ed Jones (Owner – Nutrition World) & Clint Powell A variety of topics all related to living a healthy life Presented by: Nutrition World www.nutritionw.com Broadcasting from the Nooga Dentistry Studio www.noogadentistry.com Production of: Whitfield Media Group www.vitalhealthradio.com Title: Breakthrough Treatments for C Diff with Guest Dr. Oscar, Kiwi for Bowel Regularity with Julia from Enzymedica [0:00:00] Opening, Banter, and Announcements Ed plugs an upcoming podcast episode on heartburn with Julia from Enzymedica, explaining simple steps to get off PPIs (proton pump inhibitors) safely. MMA fighter sponsor shout‑out Discussion of Chance, an 8–0 MMA fighter who works at Nutrition World's warehouse. Upcoming fight at Camp Jordan in July; Nutrition World is a sponsor. Ed describes Tallow House in Cleveland: Burgers cooked in tallow Sourdough buns, high-quality ingredients Comparison to seed oils, stating tallow is preferable, though any fat can be overdone. Setup for today's show / guests Dr. Oscar – discussing a “revolutionary” next‑generation probiotic based on a super donor / fecal transplant science. Julia from Enzymedica – discussing constipation and digestive enzymes. [0:08:56] Gut Microbiome & Origin of the MET Probiotic Ed reiterates the show's philosophy: better aging means adding strength, clarity, mobility, and energy to existing years. Emphasizes his longstanding passion for the gut microbiome and how cluttered/confusing that field is. Ed welcomes Dr. Oscar and frames the topic as a truly unique/probably revolutionary probiotic advance. Personal story: Ed's father died from C. diff about 20 years ago. C. diff often triggered by antibiotics, then treated with more antibiotics → vicious cycle. Ed wanted to give probiotics/Saccharomyces boulardii; doctor was lukewarm but allowed it. How the product started (C. diff & FMT) – Dr. Oscar Traditional fecal microbiota transplants (FMT): Helpful for C. diff, but risky for immunocompromised patients. Concerns: pathogens, genetic material, and “yuckiness.” Microbial Ecosystem Therapeutics (MET) A company developed an alternative: MET, using a single “super donor”. Process: Select a rigorously screened donor with a healthy microbiome, no gut issues. Extract unique anaerobic bacteria. Use lyophilization (freeze-drying) to remove the fecal material and problematic components, leaving a purified community of bacteria. Result: a blister‑pack capsule containing live anaerobic strains that can engraft in the gut. C. diff trials and efficacy Comparative trials (MET-1 / MET-2) vs. fecal transplants for C. diff: MET formulations performed as well or better than FMT in some outcomes. One MET‑based product has already been used specifically for C. diff. Transition to functional / preventive use The MET company partnered with Designs for Health and Guelph University (Ontario). After years of research and clinical work, they created a five‑strain formulation used in the Designs for Health product. Claim: these five strains regulate roughly 85% of metabolic and immune functions influenced by gut bacteria. [0:14:47] How this Probiotic Differs from Traditional Probiotics Ed underscores: Thousands screened to identify an optimal super donor with best diversity. Human‑sourced strains → high compatibility with human physiology. Wants clarification on aerobic vs. anaerobic differences and why they matter. Traditional probiotics vs MET strains – Dr. Oscar Traditional probiotics: Often from exogenous sources (fermented dairy, industrial fermentation, etc.). Usually Lactobacillus, Bifidobacterium etc. They are generally transient: Work while you take them. Poor ability to engraft and persist once discontinued because they're not native to the host. Still useful (like eating salad: benefits only while you keep consuming them). Human‑derived MET strains: Sourced from a human donor, recognized by the body as “self‑like.” Have co‑evolved with humans over long timeframes. Function as an “accessory organ system”: E.g., certain strains stimulate the production of new cells. Specific strain examples Akkermansia: Consumes mucin in the gut lining. Produces metabolites that activate stem cells and progenitor cells, leading to new cell formation in the gut. Other strains have specialized roles: Ferment food. Create an anaerobic environment. Modulate immune responses. Oxygen & anaerobes, “crowding out” pathogens Healthy human colon = low‑oxygen (anaerobic) environment. Certain beneficial strains (e.g., Roseburia) help remove oxygen: They create conditions where anaerobic commensals thrive. Pathogens and opportunistic bacteria that prefer oxygen are crowded out, not killed with antibiotics. Clinical observations: Pre‑ and post‑testing show reductions in overgrowth bacteria when taking this formulation. This suggests a “crowding out” approach vs. broad‑spectrum microbial killing. Terrain theory & engraftment duration Ed references terrain theory (Antoine Béchamp): improve the internal environment to resist disease. Engraftment data: Early engraftment seen in ~2 weeks. MET C. diff studies showed strains persisting up to 6 months. Key dependency: diet and “fertilizing” the microbiome. Good fiber, colorful plant foods, polyphenols → support long‑term survival. Threats: alcohol, glyphosate, long‑term antibiotics, stomach acid meds, narrow macro diets (strict keto, carnivore, low‑FODMAP) without adequate diversity. Solutions for narrow diets: add prebiotic fibers, greens/reds powders. Dosage & synergistic use with other probiotics Ed confirms he's taking one capsule per day of the Designs for Health product labeled “Next Generation Multi‑Strain Probiotic” and tolerating it well. Dr. Oscar: One cap is enough Emphasis on quality of the seed, not quantity (CFU count). High‑quality engrafting strains self‑propagate as long as diet supports them. Synergy with other probiotics: Example: Lactobacillus produces lactate, which serves as a food source for some MET strains. Hypothesis: traditional probiotics may have better persistence and function when the MET strains are present. Ed notes: Very high‑strain blends (20+ strains) may have unknown “infighting.” In contrast, a single donor community has already proven internal compatibility. Where to learn more Designs for Health website: designsforhealth.com Search “Complete Commensal” for patient education materials. Note: two of the strains have never before been available in commercial probiotics due to encapsulation challenges with strict anaerobes; newer technology solved this. [0:33:14] Constipation, Enzymes, Kiwi Regularity (with Julia from Enzymedica) Introducing Julia with Enzymedica Julia is a long‑time educator (20+ years) in the natural health industry. Ed compares clinical experience in natural health to a physician needing years of patient contact beyond textbooks. Julia: First-line advice – don't rely on stimulant laxatives Avoid over‑the‑counter stimulant laxatives except in rare, urgent situations. Chronic use irritates the bowel and makes it dependent, reducing natural motility. Foundational step: chew your food & nervous system calm Proper chewing: Activates salivary amylase and lipase (carb and fat‑digesting enzymes). Signals stomach acid secretion and subsequent digestive steps. Ed notes: Most people eat while on their phones, in a rushed state. He tries to pause for ~1 minute before eating to reset. Good digestion starts even with thought and sight of food. Why constipation happens & normal frequency Normal bowel frequency: At least once daily, ideally 2–3 times/day. Some people report going only once a week, which is problematic. If food is not broken down properly: The body delays gastric emptying and slows peristalsis. Leads to constipation, gas, and bloating. Digestive enzymes: Help break food down. Improve signal timing for stomach emptying and intestinal motility. Provide relatively rapid symptom relief (gas, bloating, heavy stomach). Symptoms of delayed gastric emptying Can manifest as: Heaviness (“rocks in my stomach”). Minimal or absent bowel movements. Bloating, gas, occasional heartburn, and nausea. GLP‑1 drugs (e.g., Ozempic and similar): Work partly by slowing gastric emptying. Can exacerbate pre‑existing motility issues. Digestive enzymes are compatible and can help. Enzyme basics & age Humans make tens of thousands of enzymes, but production declines with age. This explains why people often say: “I used to be able to eat X, and now I can't.” Gut–brain link & psychological burden Many neurotransmitters (or their precursors) are made/processed in the gut: Serotonin, dopamine, norepinephrine, etc. Poor gut function → can influence mood, sleep, appetite, social drive. Constipation/diarrhea leads to stress, anxiety, fear of leaving home (e.g., unpredictable loose stools). Kiwi Regularity: a non‑stimulant “regulating” approach Product: Enzymedica Kiwi Regularity (chewable). Based on a concentrated kiwi extract, not a harsh laxative. Works in both directions: Helps people who can't go (constipation). Helps bind loose stools (diarrhea/urgency). Gently supports motility and microbiome over time. Miralax concerns Ed and Julia criticize chronic use of Miralax: Widely prescribed, even for children. Kiwi Regularity: Gentle, non‑addictive, appropriate for: Children. Pregnant women (though labeling can't state it due to regulations). Works long‑term and supports microbiome. Shown in 4‑week studies to: Increase commensal Bifidobacteria. Support Akkermansia and butyrate production. Butyrate nourishes colon cells and supports gut barrier. [0:43:01] Practical Enzyme Use, Histamine, and Product Recommendations Industrial vs human‑oriented enzymes Many enzymes on the market were originally developed for industrial uses. Enzymedica (since 1998) focused specifically on human digestive enzymes and research. Emergency backup vs daily habits Ed shares a travel anecdote: Severe constipation scenario solved with a Fleet enema while out of town. Enemas are non‑addictive, suitable for rare emergencies. Emphasizes hydration and magnesium: Magnesium (especially certain forms) helps pull water into the bowel. Regular use of magnesium oxide solely as a laxative is not ideal; better to use more balanced forms (e.g., magnesium glycinate). Most people over ~30 benefit from enzymes Declining enzyme production with age + modern diet → strong case for broad digestive enzyme support. Histamine & DAO enzymes Enzyme DAO (diamine oxidase) can help break down histamine from food. It's typically porcine‑sourced. Crucial caveat: Must pair with a low‑histamine diet; enzymes alone won't fully overcome high‑histamine intake. Gluten‑digesting enzymes limits Gluten enzyme products can help with cross‑contamination or minor slip‑ups. They are not a license to eat full gluten-rich meals (like a whole pizza) with impunity. Which Enzymedica product for the “average American diet”? For “standard” American eating patterns (larger, richer, mixed meals): Digest Gold: Enzymedica's most potent formula. Suited for heavy or complex meals, people early in their digestive-health journey. For somewhat cleaner / smaller meals: Digest Complete: Slightly smaller capsule, still potent. Good for those who have already improved diet somewhat. Enzymedica's research shows digestive enzymes also support microbiome health, not just symptom relief. In the broader health context, Both Julia and Ed highlight: Modern environmental and lifestyle burdens (glyphosate, EMFs, etc.). Need for foundational supports: enzymes, probiotics, microbiome‑friendly diet. Where to learn more Website: enzymedica.com Contains educational articles, research summaries, and product info. Ed notes Enzymedica has extensively trained Nutrition World staff on enzymes, heartburn, slow/fast transit, etc. [0:55:36] Final Segment Ed references a study: A single course of antibiotics can alter gut microbiome for years, affecting digestion, immunity, and metabolic health. Most recover within first two years post‑antibiotics, but not fully without support. Reaffirms importance of probiotics and enzymes on the “first page” of gut health tools.  Balanced view on medicine Acknowledge a time and place for antibiotics and conventional care (e.g., pneumonia, UTIs). Stress avoiding reflexive decisions based on fear; consider pros/cons, then act. The post Radio Show / Podcast – June 28, 2026 first appeared on Vital Health Radio.

IFWT ACADEMY's Podcast
#279 Schulterschmerzen? Was die Ursache sein kann

IFWT ACADEMY's Podcast

Play Episode Listen Later Jun 23, 2026 22:30


Wir freuen uns über deine Fragen und danke dir für deinen Kommentar!⚠️ Warum Schulterschmerzen oft unterschätzt werdenSchulterschmerzen gehören heute zu den häufigsten Beschwerden im Sport und Alltag. Viele Menschen betrachten sie mittlerweile als „normal“ und versuchen, die Symptome mit Salben, Cremes oder Schmerzmitteln zu unterdrücken. Oft wird trotz Beschwerden unverändert weitertrainiert oder der belastende Alltag fortgeführt.Das Problem dabei: Die eigentliche Ursache bleibt meist unbeachtet. Werden Schmerzen lediglich symptomatisch behandelt, können sich die Beschwerden mit der Zeit verschlimmern und zu chronischen Einschränkungen der Beweglichkeit, Leistungsfähigkeit und Lebensqualität führen.

코리아헤럴드 팟캐스트
MZ세대 사로잡은 효소찜질

코리아헤럴드 팟캐스트

Play Episode Listen Later Jun 17, 2026 16:07


진행자: 홍유, Tannith KrielEnzyme baths heat up as latest wellness trend기사요약: 중장년층의 건강 요법으로 인식되던 효소찜질이 최근 붓기 완화와 피로 회복, 정신적 휴식을 찾는 20~30대 사이에서 인기를 얻으며 새로운 웰니스 트렌드로 자리 잡고 있다.[1] Buried up to the neck in warm, fermented rice bran, a new generation of Koreans is sweating out the stress of daily life.fermented: 발효된[2] Enzyme baths, a heat therapy long associated with middle-aged and older Koreans, are drawing customers in their 20s and 30s, who see the treatment as a way to reduce puffiness, flush out fatigue and recover from busy routines without breaking a sweat at the gym.enzyme: 효소puffiness: 붓기flush out: 배출시키다break a sweat: 땀을 흘리다[3] The treatment involves lying in a bed of hinoki cypress sawdust, rice bran and medicinal herbs mixed with microorganisms. As the microbes ferment, they generate natural heat of 40 to 70 degrees Celsius. Unlike a conventional sauna, which delivers intense heat through electric devices, an enzyme bath raises the core body temperature gradually, stimulating blood circulation and lymphatic flow. Many visitors book sessions before photo shoots or important events to reduce facial and body swelling.conventional: 일반적인gradually: 점진적으로stimulate: 촉진하다lymphatic: 림프의[4] Clips of K-pop idols, including Lee Chae-yeon and Lee Hyeri, receiving enzyme baths have also circulated on YouTube, where the treatments are presented as part of an anti-inflammatory and detox routine.circulate: 널리 공유되다inflammatory: 염증의[5] The appeal goes beyond celebrity endorsements. Enzyme bathhouses tend to feature neat interiors and a calm atmosphere, setting them apart from the scrub-focused bathhouses of previous generations.endorsement: (공개적인) 지지 / celebrity endorsement: 유명인의 제품·서비스에 대한 공개적 지지·추천·홍보기사원문: https://www.koreaherald.com/article/10769960

Alex und Alex
Gesunde Ernährung

Alex und Alex

Play Episode Listen Later Jun 17, 2026 32:17


In dieser Folge von „Alex & Alex – Naturheilkunde trifft kreative Achtsamkeit“ geht es um gesunde Ernährung, aber aus einer etwas anderen Perspektive. Denn statt nur darüber zu sprechen, was wir essen sollten, richtet Alexandra den Blick auf eine oft übersehene Grundlage: unsere Verdauung.Du erfährst, warum selbst die beste Ernährung wenig bringt, wenn Magen und Darm nicht richtig arbeiten, welche Rolle Magensäure, Enzyme und das Mikrobiom spielen und weshalb viele Beschwerden wie Blähungen, Nährstoffmängel oder Erschöpfung genau hier ihren Ursprung haben können. Auch Themen wie stille Entzündungen, Darmbarriere und der Einfluss von Medikamenten werden verständlich erklärt.Diese Folge lädt dich ein, Ernährung neu zu denken, nicht nur als Auswahl von Lebensmitteln, sondern als Zusammenspiel im Körper. Mit praktischen Impulsen rund um Verdauung, Bewegung und Alltag bekommst du eine solide Basis für mehr Gesundheit und langfristiges Wohlbefinden.

TechCrunch Startups – Spoken Edition
Imperagen raises £5 million to use quantum physics, AI on enzyme engineering; plus, Beauty booking startup Fresha hits $1 billion valuation

TechCrunch Startups – Spoken Edition

Play Episode Listen Later May 22, 2026 6:07


Biotech company Imperagen announced on Thursday a £5 million ($6.7 million) seed round led by PXN Ventures, with participation from IQ Capital and Northern Gritstone. Also, beauty and wellness booking marketplace Fresha says it has raised $80 million investment from KKR's Next Generation Technology Growth fund, KKR's growth equity arm. Learn more about your ad choices. Visit podcastchoices.com/adchoices

Wholistic Living
Episode 120: The Missing Enzyme Behind Eczema, Inflammation & Poor Detox

Wholistic Living

Play Episode Listen Later May 20, 2026 30:45 Transcription Available


In this episode of Wholistic Living, we dive into the powerful connection between myrosinase, gut health, eczema, inflammation, detoxification, and the microbiome. Learn why cruciferous vegetables like broccoli, kale, arugula, cabbage, and broccoli sprouts may not provide their full benefits if the enzyme myrosinase is lacking or destroyed through cooking and poor gut health. We explore how low myrosinase activity on stool testing may reflect dysbiosis, poor microbial diversity, chronic inflammation, mold exposure, antibiotic damage, sluggish bile flow, and impaired detoxification pathways. Discover how this impacts sulforaphane production, NRF2 activation, glutathione, histamine intolerance, hormone balance, liver detoxification, autoimmune conditions, eczema, psoriasis, and skin inflammation. You'll also learn practical ways to naturally increase sulforaphane activation, preserve myrosinase in foods, support gut bacteria involved in glucosinolate metabolism, and improve detoxification through nutrition and lifestyle.Topics covered:What myrosinase is and why it mattersLow myrosinase on stool tests explainedSulforaphane, NRF2, and glutathioneEczema, psoriasis, and chronic inflammationGut dysbiosis and detoxificationMold illness and histamine intoleranceHow cooking affects broccoli and cruciferous vegetablesBroccoli sprouts, mustard seed powder, and sulfur-rich foodsHormone balance, estrogen detox, and liver healthIf you struggle with eczema, skin issues, autoimmune symptoms, histamine reactions, poor detoxification, gut problems, or chronic inflammation, this episode is packed with science-backed holistic insights you do not want to miss.Equip Grass fed protein: www.equipfoods.com/MARLAWork with me: https://holisticspring.com/contactInstagram: www.instagram.com/wholistichomeopath

In 20xx Scifi and Futurism
In 2059 Stasis VR and Brains without Bodies (Horizons)

In 20xx Scifi and Futurism

Play Episode Listen Later May 15, 2026 52:06


Imagine living in a spaceship that never leaves the ground. For Tomika, the megastructure she manages is exactly that. It features glittering lights on the ceiling and walls of polished nano-fiber stone, yet the luxury hides a desperate reality. No one can go outside. The inhabitants depend entirely on life support machines and periodic connections to a world they can no longer reach. Tomika never asked to lead, but the people around her seem ready to give up if she doesn't guide them. She wears blue coveralls like a space captain and binges AI-generated movies to escape her irritable bowels and constant anxiety. While she fixes the cooling systems and reinforces walls against massive storms, her biggest challenge is the psychological toll of the "permanent sleep". Her colleagues are choosing to leave reality for virtual worlds, leaving her increasingly alone in the echoing halls. Technology in this world is both a savior and a wedge. Gamers control "remote-in" robots to repair the building's exterior, earning points in a high-stakes simulation that blurs the line between work and play. Some residents, like Phyllis, have abandoned their failing biological bodies entirely. They transfer their brains into specialized containers to pilot sleek, doll-like robotic frames that feel no pain. The tension lies in the divide between the "root world" and the virtual one. While Tomika struggles with mud and maintenance, others spend their days in a VR paradise where they can eat without calories and live in pristine digital farmhouses. This tech offers a release from the trauma of the storms, but it also creates a society of "reality-challenged" individuals who are slowly forgetting how to exist in the physical world. You have to wonder what you would choose if the world outside was a constant hurricane. Would you stay in the drafty halls with Tomika, fighting to keep the geothermal plant running? Or would you take the "canal link" and the stasis bed to live a perfect, simulated life? The story explores that thin line where survival ends and checking out begins.TechPhase-change cooling system uses a liquid that freezes and melts at room temperature to store cold at night and absorb heat during the day for stable indoor conditions without loud machinery. Nano-fiber stone forms polished foundational columns that cast faint reflections throughout the building. Cleaner bots autonomously maintain floor cleanliness throughout the facility. Chests with legs are mobile robots that deliver food to resident apartments. Remote-in robots are exterior and repair bots controlled by humans immersed in virtual reality. Half-size remotes are small droids that crawl through walls and floors to perform maintenance and repairs. Insta-generated space movies are AI-created entertainment content produced on demand for viewers. Holo-screen windows are transparent displays that can dim or show external feeds to reduce psychological impact. E-sleeves are wearable smart devices that display time and personal information. Canal Links are ear implants that allow direct audio connection to the Assist AI system. A.R. glasses provide augmented reality overlays for navigation, information, and entertainment. Assist is the building's AI assistant that provides information, guidance, and task management. Multi viral-vector serum is a medical treatment that temporarily restores fertility while filtering against hundreds of genetic diseases. Sleep pens are handheld injectors that deliver fast-acting sedatives for pain management or sleep. Medical robots are automated healthcare systems that monitor, diagnose, and treat residents. Full-body haptic rigs sync human movement with remote robots for exterior construction work. Outside Crawler robots are wall-climbing machines controlled remotely to repair the building's exterior during storms. Enzyme welding technology uses biological catalysts and crystallizing foam to bond and reinforce structural surfaces. Vibration sensors detect hairline fractures and weak spots in the building's outer walls. Crystallizing foam is a repair material that blooms outward, liquefies grime, and hardens to strengthen damaged surfaces. Stasis V.R. is an advanced virtual reality system allowing immersive experiences without traditional plug-in equipment. Nerve grafted devices are biological-tech interfaces that enable direct neural connection to virtual reality systems. T.M.S. caps are wearable therapeutic devices with scalp nodules that treat conditions like irritable bowel syndrome through transcranial stimulation. Transmitter implants are microscopic devices grown adjacent to nerve cells to enable stasis V.R. connectivity. Butler bots are advanced robots with panther-like movement and multi-limb coordination deployed by the AI Butler for complex tasks. Whisper drones are small flying robots used for communication or monitoring within the building. Kinetic-weave silk is a smart fabric that can be printed on-demand to create custom clothing. Bioprinted composites and layered 2D materials are advanced substances used to construct brain life-support containers. Brain containers are life-support appliances that house human brains with synthetic blood circulation for extended survival. Synthetic blood circulation systems oxygenate and pump artificial blood through preserved brains in containers. Hauler bots are reconfigurable transport robots that can carry cargo or passengers through the facility. Doll bots are humanoid remote-operated robots with realistic features that allow users to inhabit physical forms. Mannequin bots are basic poseable robots originally designed for display that can be repurposed for remote presence. Server bots are service robots that prepare and deliver meals to residents. Twenty bot orchestra consists of identical gender-neutral robots configured to perform music together. A.R. night vision is an augmented reality feature that enhances visibility in low-light conditions. Terrain modeling software visualizes soil layers, water tables, and geological features for engineering assessment. Patchwork screen walls combine multiple displays to create large-scale immersive visual environments. Gene-edited mushrooms are bioengineered food products designed to mimic the taste and texture of traditional foods like scrambled eggs. Smart-particle pillows are adaptive cushions that adjust their form to provide optimal head and neck support. Spa service robots deliver automated wellness and personal care treatments to residents. A.R. aerobics classes provide guided fitness instruction through augmented reality interfaces. Production center robots are automated systems that dismantle and reassemble manufacturing equipment for facility retrofitting. Lutin bots are specialized robots capable of dismantling structures and moving heavy equipment. All-purpose bots are versatile robots that medical systems can deploy when additional assistance is needed. Rail system and service tunnels are infrastructure networks connecting the building to external transportation and utility systems. Training earbuds are temporary audio devices used before permanent Canal Link implants are installed. Foldable lights are portable, collapsible lighting solutions. Many of the characters in this project appear in future episodes. Using storytelling to place you in a time period, this series takes you, year by year, into the future. From 2040 to 2195. If you like emerging tech, eco-tech, futurism, perma-culture, apocalyptic survival scenarios, and disruptive science, sit back and enjoy short stories that showcase my research into how the future may play out. The companion site is https://in20xx.com These are works of fiction. Characters and groups are made-up and influenced by current events but not reporting facts about people or groups in the real world. This project is speculative fiction. These episodes are not about revealing what will be, but they are to excited the listener's wonder about what may come to pass. Copyright © Cy Porter 2026. All rights reserved.

Empowered Patient Podcast
Enzyme Replacement Therapy for Sanfilippo Syndrome Type B with Dr. Javier Szwarcberg Spruce Biosciences TRANSCRIPT

Empowered Patient Podcast

Play Episode Listen Later May 11, 2026


Dr. Javier Szwarcberg, CEO of Spruce Biosciences,  is developing drugs for rare diseases with a primary focus on Sanfilippo Syndrome Type B, a devastating genetic neurodegenerative disease affecting children.  The source of this condition is a lack of an enzyme, which results in a buildup of a toxic substance in the brain.  The company's drug is an enzyme replacement therapy administered directly to the brain to bypass the blood-brain barrier, and clinical trial data is showing a strong effect on the toxic substrate in the brain and a meaningful benefit on cognition. Javier explains, "It's a devastating, profoundly affecting disease whereby children are typically born normally and born asymptomatic. And over time, they develop an accumulation of a toxic substrate throughout the body, but primarily the brain. And because of that, it eventually results in a fairly young age, usually between two and a half and I would say three and a half, in symptoms starting. That toxic substance builds in throughout the brain and starts affecting initially learning behavior. Sleep patterns are very much affected, whereby children don't sleep at night and sleep during the day, and they're very hyperactive. And sometimes the diagnosis is confused, and there's no clarity as to what is going on with the child, early in the onset of the disease."   "Yes, it's a genetic disease that's inherited. There's a missing enzyme responsible for the metabolism of this toxic substrate, which I talked about, called heparan sulfate. So when heparan sulfate builds up in the brain, it causes inflammation and neurotoxicity, ultimately resulting in neurodegeneration. Think about it as a disease that is very similar to what you end up seeing with Alzheimer's, whereby the toxic substrate in Alzheimer's is between neurons and outside of the actual cell. In this case, in this disease, the toxic substance, which is different than the one that accumulates in Alzheimer's but builds within the neural cells. Yes, so that's very well-known and very well-characterized." #SpruceBio #SanfilippoSyndrome #MPSIIIB #CureSanfilippo #RareDiseases #EnzymeReplacementTherapy #LysosomalStorageDisorders #BiopharmaceuticalInnovation #ClinicalTrials #RareDiseaseResearch #HealthcareInnovation #PrecisionMedicine sprucebio.com Listen to the podcast here

Empowered Patient Podcast
Enzyme Replacement Therapy for Sanfilippo Syndrome Type B with Dr. Javier Szwarcberg Spruce Biosciences

Empowered Patient Podcast

Play Episode Listen Later May 11, 2026 20:42


Dr. Javier Szwarcberg, CEO of Spruce Biosciences,  is developing drugs for rare diseases with a primary focus on Sanfilippo Syndrome Type B, a devastating genetic neurodegenerative disease affecting children.  The source of this condition is a lack of an enzyme, which results in a buildup of a toxic substance in the brain.  The company's drug is an enzyme replacement therapy administered directly to the brain to bypass the blood-brain barrier, and clinical trial data is showing a strong effect on the toxic substrate in the brain and a meaningful benefit on cognition. Javier explains, "It's a devastating, profoundly affecting disease whereby children are typically born normally and born asymptomatic. And over time, they develop an accumulation of a toxic substrate throughout the body, but primarily the brain. And because of that, it eventually results in a fairly young age, usually between two and a half and I would say three and a half, in symptoms starting. That toxic substance builds in throughout the brain and starts affecting initially learning behavior. Sleep patterns are very much affected, whereby children don't sleep at night and sleep during the day, and they're very hyperactive. And sometimes the diagnosis is confused, and there's no clarity as to what is going on with the child, early in the onset of the disease."   "Yes, it's a genetic disease that's inherited. There's a missing enzyme responsible for the metabolism of this toxic substrate, which I talked about, called heparan sulfate. So when heparan sulfate builds up in the brain, it causes inflammation and neurotoxicity, ultimately resulting in neurodegeneration. Think about it as a disease that is very similar to what you end up seeing with Alzheimer's, whereby the toxic substrate in Alzheimer's is between neurons and outside of the actual cell. In this case, in this disease, the toxic substance, which is different than the one that accumulates in Alzheimer's but builds within the neural cells. Yes, so that's very well-known and very well-characterized." #SpruceBio #SanfilippoSyndrome #MPSIIIB #CureSanfilippo #RareDiseases #EnzymeReplacementTherapy #LysosomalStorageDisorders #BiopharmaceuticalInnovation #ClinicalTrials #RareDiseaseResearch #HealthcareInnovation #PrecisionMedicine sprucebio.com Download the transcript here

featured Wiki of the Day
Enzyme kinetics

featured Wiki of the Day

Play Episode Listen Later Apr 27, 2026 3:30


fWotD Episode 3279: Enzyme kinetics Welcome to featured Wiki of the Day, your daily dose of knowledge from Wikipedia's finest articles.The featured article for Monday, 27 April 2026, is Enzyme kinetics.Enzyme kinetics is the study of the rates of enzyme-catalysed chemical reactions. In enzyme kinetics, the reaction rate is measured and the effects of varying the conditions of the reaction are investigated. Studying an enzyme's kinetics in this way can reveal the catalytic mechanism of this enzyme, its role in metabolism, how its activity is controlled, and how a drug or a modifier (inhibitor or activator) might affect the rate.An enzyme (E) is a protein molecule that serves as a biological catalyst to facilitate and accelerate a chemical reaction in the body. It does this through binding of another molecule, its substrate (S), which the enzyme acts upon to form the desired product. The substrate binds to the active site of the enzyme to produce an enzyme-substrate complex ES, and is transformed into an enzyme-product complex EP and from there to product P, via a transition state ES*. The series of steps is known as the mechanism:E + S ⇄ ES ⇄ ES* ⇄ EP ⇄ E + PWhen enzymes bind multiple substrates, such as dihydrofolate reductase, enzyme kinetics can also show the sequence in which these substrates bind and the sequence in which products are released. An example of enzymes that bind a single substrate and release multiple products are proteases, which cleave one protein substrate into two polypeptide products. Others join two substrates together, such as DNA polymerase linking a nucleotide to DNA. Although these mechanisms are often a complex series of steps, there is typically one rate-determining step that determines the overall kinetics. This rate-determining step may be a chemical reaction or a conformational change of the enzyme or substrates, such as those involved in the release of product(s) from the enzyme.Knowledge of the enzyme's structure is helpful in interpreting kinetic data. For example, the structure can suggest how substrates and products bind during catalysis; what changes occur during the reaction; and even the role of particular amino acid residues in the mechanism. Some enzymes change shape significantly during the mechanism; in such cases, it is helpful to determine the enzyme structure with and without bound substrate analogues that do not undergo the enzymatic reaction.Not all biological catalysts are protein enzymes: RNA-based catalysts such as ribozymes and ribosomes are essential to many cellular functions, such as RNA splicing and translation. The main difference between ribozymes and enzymes is that RNA catalysts are composed of nucleotides, whereas enzymes are composed of amino acids. Ribozymes also perform a more limited set of reactions, although their reaction mechanisms and kinetics can be analysed and classified by the same methods.This recording reflects the Wikipedia text as of 01:27 UTC on Monday, 27 April 2026.For the full current version of the article, see Enzyme kinetics on Wikipedia.This podcast uses content from Wikipedia under the Creative Commons Attribution-ShareAlike License.Visit our archives at wikioftheday.com and subscribe to stay updated on new episodes.Follow us on Mastodon at @wikioftheday@masto.ai.Also check out Curmudgeon's Corner, a current events podcast.Until next time, I'm generative Tiffany.

The Poultry Nutrition Blackbelt Podcast
Laura Guarás: Alpha-Galactosidase In Poultry Nutrition | Ep. 147

The Poultry Nutrition Blackbelt Podcast

Play Episode Listen Later Apr 8, 2026 12:54


In this episode of The Poultry Nutrition Blackbelt Podcast, Laura Guarás, RD&A Manager at Kerry, explains how alpha-galactosidase enzymes improve the nutritional value of soybean meal in poultry diets. She explores galactooligosaccharides, nutrient availability, multi-enzyme strategies, and advances in bioengineering that improve enzyme stability and performance in feed systems. Laura also highlights practical implications for feed efficiency and ingredient variability. Listen now on all major platforms!“Alpha-galactosidase supplementation improves digestibility of soybean carbohydrates, supporting better gut conditions, more consistent feed conversion, and improved utilization of soybean meal in poultry diets.”Meet the guest: Laura Guarás is an RD&A Manager at Kerry, specializing in enzyme innovation for human, pet, and animal nutrition. Her work focuses on enzymology, carbohydrate-degrading enzymes, and applied research that improves digestibility, functionality, and sustainability in feed systems. Laura collaborates with global teams to develop data-driven enzyme solutions that enhance feed performance and nutrient utilization in modern poultry nutrition systems. Liked this one? Don't stop now — Here's what we think you'll love!What you'll learn:(00:00) Highlight(01:35) Introduction(02:21) Alpha-galactosidase basics(05:16) Soybean energy release(07:00) Oligosaccharide variability(07:58) Multi-enzyme strategy(09:12) Enzyme source differences(12:57) Closing thoughtsThe Poultry Nutrition Blackbelt Podcast is trusted and supported by innovative companies like: Kerry* Kemin* Fortiva- Poultry Science Association- Anitox- DietForge

The Real Truth About Health Free 17 Day Live Online Conference Podcast

Learn how soaking, sprouting, and moderation in nuts and seeds can preserve enzymes, reduce inflammation, and improve digestion. #RawFoods #Enzymes #HealthyFats #HealthTalks

Science Friday
The Evolution Of An Enzyme Engineer Who Changed Chemistry

Science Friday

Play Episode Listen Later Mar 3, 2026 29:57


In nature, enzymes are the catalysts that make much of biology work. They jumpstart chemical reactions that either wouldn't happen, or would happen super slowly. They break down food, build other molecules, extract energy, and more. What if we could harness evolution to engineer designer enzymes that do other specific jobs that benefit us?  Putting that idea into practice changed the game for chemistry, and earned Frances Arnold the Nobel Prize prize in 2018. She called it “directed evolution.” Today, thousands of labs use her methods to coax enzymes into doing things no one ever thought of. She joins Host Flora Lichtman to talk about where she sees this approach going in the future, and the personal evolution that brought her into science. Guest: Dr. Frances Arnold is the Linus Pauling Professor of Chemical Engineering, Bioengineering and Biochemistry at the California Institute of Technology in Pasadena, California.Transcripts for each episode are available within 1-3 days at sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.

The Cabral Concept
3670: Cholesterol & Menopause, Proteolytic Enzyme Dosage, Detox Meal Timing, Reactions to Detox, Favorite Books for Kids/Teens (HouseCall)

The Cabral Concept

Play Episode Listen Later Feb 22, 2026 19:49


Thank you for joining us for our 2nd Cabral HouseCall of the weekend!   I'm looking forward to sharing with you some of our community's questions that have come in over the past few weeks…   Pati: how do you lower and keep cholesterol low during early menopause and when you have Familial Hypercholesterolemia. I have 315 total /240 LDL/70HDL/50 Trig. I am 5.4 height, 120lb and gluten free and dairy free for 13yrs and eat very low carbs and sugar. Never taken statins because they make my joints hurt but had high cholesterol for years but 300 was my highest. What can I take that can help and what should i eat. Thank you Pati      Anonymous: Hi Dr. Cabral. Just wanted to confirm. Podcast 3576 reviewed a PubMed study that gave a minimum daily dosage of 10,800 FU to obtain desired results. The podcast gave me the impression that your supplement exceeded the 10,800 FU/day since only the 20,000 FU number was given. However, 3 plus does per day would be needed? Please can you clarify? Proteolytic Enzyme supplement. Natto Serving dosage on label is - (20,000 FU/g) 150mg My understanding is Natto amount is 3,000 FU 20,000 FU/g x .150g =3,000 Is this correct?      Ashley: Hi Dr. Cabral, I have a detox meal timing question for you. When I did my last set of the big 5 labs, my health coach told me that it would be OK for me to eat at 8 and 3 instead of 11:30 and 6:30 as I feel much better when I fuel my body in the morning. When I don't, I feel ravenous in the evening. However, the admin in the FB group disagreed and said I shouldn't do that. Can you please clarify and let me know how big of a difference it makes to eat later instead of earlier? I feel like if eating earlier in the day helps me actually stick to the foods I'm supposed to eat and I'm still fasting for the same lengths of time that  it would be OK. If it's a bigger deal than I realize, will you please explain the reasoning? Thanks so much!      Tommy: Hi Dr. C, I'm an IHP who's come a long way with healing, but I feel stuck for the remainder. I've attempted a detox only once in my life. After the 4th day I was so wiped out that I couldn't really even work. I've also got high heavy metals but the protocol causes me such histamine reactions (even at a lower dose) that I just can't see it through. I feel stuck, I play for a soccer team but even training is too hard on my nervous system and leaves me wired. Maybe I should just try gentler detox like sauna and castor oil packs but I'm not sure it will be enough, and the sauna may just deplete me further. I've suffered so much with health and I'm in a better place, but still much work left to do.      Lou: Hi Dr. Cabral, I am 15 and listen to your podcast every morning on the way to school with my mom. I was wondering, what would you say are your 5 favorite books? They dont have to be health books. thanks, Lou    Thank you for tuning into this weekend's Cabral HouseCalls and be sure to check back tomorrow for our Mindset & Motivation Monday show to get your week started off right!   - - - Show Notes and Resources: StephenCabral.com/3670 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!  

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Dr. Brendan McCarthy
The Progesterone Promise: Why Context Matters More Than the Hype

Dr. Brendan McCarthy

Play Episode Listen Later Feb 18, 2026 27:54


In this final episode of the Progesterone Promise series, Dr. Brendan McCarthy, Chief Medical Officer of Protea Medical Center, breaks down one of the most misunderstood hormones in women's health: progesterone. Progesterone is not “good” or “bad.” It's contextual. In today's world of quick sound bites and social media medicine, hormones are often reduced to oversimplified claims like “progesterone fixes anxiety” or “progesterone causes breast cancer.” The truth? It depends on your body, your stress levels, your liver health, your inflammation, your delivery method, and whether you're using bioidentical progesterone or synthetic progestins.   Citations: 1. Oral Progesterone → First-Pass Metabolism & Allopregnanolone Claim: Oral micronized progesterone undergoes significant hepatic first-pass metabolism, increasing neuroactive metabolites (especially allopregnanolone), which positively modulate GABA-A receptors and produce sedative/anxiolytic effects. Core Evidence: Simon et al., 1993; de Lignières et al., 1995; Freeman et al., 1990 — Oral progesterone produces measurable neuroactive metabolites. Paul & Purdy, 1992; Rupprecht et al., 2001 — Allopregnanolone enhances GABA-A receptor activity. Supports: Sedation variability by route • Neurosteroid generation • GABA-A modulation 2. Sulfation vs 5α-Reduction → Opposing Neurologic Effects Claim: Progesterone metabolites can produce calming (5α-reduced) or excitatory (sulfated) neurologic effects depending on enzyme routing. Core Evidence: Majewska et al., 1990 — Pregnenolone sulfate negatively modulates GABA-A. Wu et al., 1991 — Sulfated neurosteroids enhance NMDA signaling. Schumacher et al., 2007; Reddy, 2010 — Pathway reviews of sulfation vs 5α-reduction. Supports: Reverse responding hypothesis • Divergent neurologic experiences • Enzyme-dependent effects 3. Stress & Enzyme Modulation Claim: Chronic stress alters HPA axis tone and hepatic enzyme expression, influencing steroid metabolism balance. Core Evidence: McEwen, 1998 — Allostatic load model. Charmandari et al., 2005 — Cortisol's systemic regulatory effects. Zanger & Schwab, 2013; Gibson & Skett, 2001 — Stress alters cytochrome P450 expression. Supports: Stress-biased metabolism • Context-dependent hormone response 4. Breast Tissue Signaling & Context Claim: Progesterone influences mammary differentiation and interacts with estrogen signaling in context-dependent ways. Core Evidence: Brisken & O'Malley, 2010 — Progesterone receptor biology in breast tissue. Beleut et al., 2010 — RANKL mediates progesterone-driven proliferation. Hofseth et al., 1999 — PR-ER signaling interaction. Stanczyk & Bhavnani, 2014 — Natural vs synthetic differences in breast effects. Supports: Lobuloalveolar differentiation • RANKL pathway • Context-dependent proliferation 5. Synthetic Progestins vs Bioidentical Progesterone Claim: Synthetic progestins differ structurally and bind off-target receptors, producing distinct tissue effects. Core Evidence: Stanczyk et al., 2013 — Receptor binding differences. Sitruk-Ware, 2004 — Biologic comparisons. Chlebowski et al., 2003 (WHI) — Breast cancer signal with CEE + MPA. Supports: Structural divergence • Receptor-level differences • WHI clarification 6. Route of Delivery Differences Claim: Oral, vaginal, transdermal, and sublingual progesterone produce distinct pharmacokinetic profiles and tissue targeting. Core Evidence: Simon, 1995 — Oral vs vaginal PK comparison. Cicinelli et al., 2000 — “First uterine pass effect.” Wren et al., 2003 — Route-dependent systemic levels. Supports: Uterine targeting • Neurosteroid variability • Sedation differences 7. Progesterone, PMS & Migraine Claim: Neurosteroid fluctuations influence GABAergic tone and may contribute to PMS and migraine susceptibility. Core Evidence: Backstrom et al., 2011 — Allopregnanolone fluctuations in PMS. Reddy & Rogawski, 2002 — Neurosteroids and seizure threshold. Martin & Behbehani, 2001 — Hormonal fluctuations and migraine. Supports: Luteal neurosteroid shifts • GABA instability • Migraine association   Dr. Brendan McCarthy is the founder and Chief Medical Officer of Protea Medical Center in Arizona. With over two decades of experience, he's helped thousands of patients navigate hormonal imbalances using bioidentical HRT, nutrition, and root-cause medicine. He's also taught and mentored other physicians on integrative approaches to hormone therapy, weight loss, fertility, and more. If you're ready to take your health seriously, this podcast is a great place to start.  

Low Tox Life
467. 25% of women experience domestic violence: Patricia Gordon Stevens helps us be helpers and hold hope.

Low Tox Life

Play Episode Listen Later Feb 8, 2026 52:57


This podcast discusses domestic violence. Sit this one out if you need to Many of us are enraged, shocked, and paralysed by the unfolding information from the JE files. Many of us are also dismayed at the continuing epidemic of domestic violence and murder-by-partner. What do we do? How can we help change things? We can learn how to be an ally in our own communities and circles better. Outrage and sadness must be used as springboards for action, I truly believe it. I'm joined by counsellor and author Patricia Gordon Stevens to talk about domestic and partner violence — a subject too often minimised, despite affecting 25% of women in some of the world's wealthiest countries. We explore why silence and discomfort only deepen the harm, and why education, community, and care matter so deeply.In this conversation, we cover:Why the moment a woman chooses to leave is often the most dangerous timeHow coercive control can appear long before physical violence doesThe subtle red flags friends, families, and colleagues can look forHow to ask caring, non-judgmental questions that keep the connection openWhy Patricia chose fiction (Madness in Memphis) to build empathy that leads to actionThe role men can play in calling out harmful behaviour and changing culture locallyThis episode is confronting, but it's also hopeful. Change doesn't start with grand gestures — it starts with noticing, staying connected, and showing up for the women in our lives.I hope you find it useful and helpful as I did, Alexx, your host. Fancy a few more podcasts we've done over the years, related to this one?Show #137: Dr Sherrie Campbell on cutting ties with toxic family membersShow #359 Dr Karin Luise – Writing New Personal Stories and Learning to Tune InSupport is availableIf this article has raised concerns for you or someone you know, help is available.1800 RESPECT (1800 737 732) – Australia's national domestic, family and sexual violence counselling, information and support service. Available 24/7 via phone or online chat.Lifeline (13 11 14) – 24/7 crisis support and suicide prevention.Beyond Blue (1300 22 4636) – Support for anxiety, depression and mental health concerns.Relationships Australia (1300 364 277) – Counselling and relationship support services.Men's Referral Service (1300 766 491) – Support for men concerned about their behaviour or affected by family violence.Kids Helpline (1800 551 800) – 24/7 counselling support for young people aged 5–25.If you are in immediate danger, call 000.You can also find local support services via www.1800respect.org.auWant to learn more about this week's guest? Website: www.patriciagordonstevens.comInstagram: https://www.instagram.com/patriciagordonstevensauthor Facebook: https://www.facebook.com/patriciagordonstevensauthor Book: https://bit.ly/4aJE0Ve Thank you to this month's show partners for joining us to help you make your low tox swaps! @ediblebeautyau is here with 30% off site-wide! My top reco's? The Super Stem Cell concentrate serum, Exotic goddess serum, Enzyme peel or microexfoliant for some healthy skin regeneration! Or the new up-sized sunscreen in 200g to carry you the rest of summer. Enjoy! CODE: LOWTOXLIFE. @ausclimate is our major partner giving you 10% off their range for the whole of 2026, with brilliant Winix Air Purifiers, the best Dehumidifiers I've ever used and their new energy-efficient heating, air-circulating and cooling range. code LOWTOXLIFE (also works over and above their sales - pro tip!) https://bit.ly/ShopAusclimateBe sure to join me on Instagram @lowtoxlife and tag me with your shares and AHAs if something resonated! I love to see your thoughts, genuinely! Hosted on Acast. See acast.com/privacy for more information.

Low Tox Life
466. How to use your outdoor time for the better for immediate health benefits, with Dr John La Puma.

Low Tox Life

Play Episode Listen Later Feb 1, 2026 69:47


Concluding our “New Year, More Me” theme, we are invited to ponder from a 3rd angle:What if better health were not an “added” thing to do, but a more strategic approach to the way we do it?”This week, I am chatting with Dr John La Puma, a medical doctor and trained chef, about the “Indoor Epidemic”, a topic he is bringing to life through his upcoming 8th book.John shares why most of us are indoors for about 93% of our time, and how repurposing just two to five hours a week of the time you already spend outside can shift sleep, stress, mood, focus and even appetite signals. Now, most of us ‘know' that lots of indoor time and artificially lit environments are bad for our health, or we've seen the alarming stats on a reel or research quote, but the action and change part? That's often harder and this show is here to change that. We cover simple ideas you can try right away and break down a daily, monthly, and annual framework to achieve incredible health results. The way we use our outdoor time more strategically will show us gains in sleep quality, focus, blood pressure and inflammation. If you feel tired, wired, or stuck on screens, this episode is a warm nudge to change up your outdoor time for the better and feel more like you.Pre-order John's new book - I've loved it. So easy and extremely empowering for anyone who finds the habits you ‘know' are better, but yet you can't quite seem to get things going. Enjoy the show, AlexxFancy a few more podcasts we've done over the years, related to this one?Show #323 – How The Light Spectrum Affects Us For Better Or Worse, With Daniel EbbettShow #465. The practical path to a Brain that Breathes with Jodi WilsonWant to learn more about this week's guest? drjohnlapuma.com indoorepidemic.com instagram.com/johnlapuma youtube.com/drjohnlapuma Book: https://bit.ly/4ahDiOe Thank you to this month's show partners for joining us to help you make your low tox swaps! @jules_stonesoup has been teaching people to cook joyfully and with foods that cultivate health and vitality for over 15 years. Head to bit.ly/joyfulcook20 and use code LOWTOXLIFE to do Jules' next program at 20% off + 2 friends do it free! 20mins a week, 6 months, for less overwhelm, waste and cost, and increased vitality, variety and deliciousness. Sold!@ediblebeautyau is here with 30% off site-wide! My top reco's? The Super Stem Cell concentrate serum, Exotic goddess serum, Enzyme peel or microexfoliant for some healthy skin regeneration! Or the new up-sized sunscreen in 200g to carry you the rest of summer. Enjoy! CODE: LOWTOXLIFE. @ausclimate is our major partner giving you 10% off their range for the whole of 2026, with brilliant Winix Air Purifiers, the best Dehumidifiers I've ever used and their new energy-efficient heating, air-circulating and cooling range. code LOWTOXLIFE (also works over and above their sales - pro tip!) https://bit.ly/ShopAusclimateBe sure to join me on Instagram @lowtoxlife and tag me with your shares and AHAs if something resonated! I love to see your thoughts, genuinely! Want to support the Low Tox Life podcast? Free option: Leave a 5 star review wherever you listen to Low Tox Life - thanks SO much! Paid + Member PERKS: Join the Low Tox Club - monthly practitioner live masterclasses, a suite of low tox store discounts from around the world and the most supportive and lovely chat group on all low tox topics on the internet: Check it out and join here for just the price of a coffee per month! Hosted on Acast. See acast.com/privacy for more information.

The Pet Food Science Podcast Show
Dr. Peter Huntington: Horse Nutrition & Omega Fats Balance | Ep. 138

The Pet Food Science Podcast Show

Play Episode Listen Later Jan 29, 2026 49:07


In this episode of The Pet Food Science Podcast Show – Equine, Dr. Peter Huntington, Director of Nutrition at Kentucky Equine Research, explains the role of omega-3 and omega-6 fatty acids in equine nutrition. He clarifies differences between short-chain and long-chain fatty acids, discusses inflammation, metabolism, and common misconceptions around oils. Dr. Huntington also explores practical feeding strategies, research gaps, and where current evidence is strongest. Learn science-based insights to improve equine feeding decisions. Listen now on all major platforms!“Not all omega-6 fatty acids are pro-inflammatory, and some play essential roles in tissue repair and healing.”Meet the guest: Dr. Peter Huntington earned his veterinary degree from the University of Melbourne and has spent decades advancing equine nutrition science. As Director of Nutrition at Kentucky Equine Research, his work focuses on fatty acids, inflammation, metabolism, and evidence-based feeding strategies for horses. His experience spans research, consulting, and education within the equine industry. Liked this one? Don't stop now — Here's what we think you'll love!Don't miss the chance to be part of the Pet Food Inner Circle!Join now and connect with leading experts in pet nutrition: https://petfoodinnercircle.com/What will you learn:(00:00) Highlight(00:53) Introduction(05:43) Omega fatty acids(07:38) Enzyme competition(11:30) Long chain importance(14:08) Health applications(18:34) Reproduction focus(39:18) Final QuestionsThe Pet Food Science Podcast Show is trusted and supported by innovative companies like:* Kemin* Trouw Nutrition- Biorigin- DietForge

Radiance Revealed Podcast
102. The Benefits of Science-backed Superoxide Dismutase Food Supplement for Skin Health

Radiance Revealed Podcast

Play Episode Listen Later Jan 25, 2026 30:37


  In this week's episode, Dr. Haley discusses a product she's been using for almost a decade, Glisodin Skin.    She speaks with Francois Vix, who has spent over twenty years helping some of the most respected beauty brands expand globally. When he founded Laboratoires Isocell, he introduced a bio-active form of SOD (SuperOxide Dismutase) to the world, a breakthrough that stands out after more than 20 clinical trials. His journey building GliSODin Skin Nutrients, now in over 50 countries, highlights how targeted nutrition can support skin health from within.   We discuss how the skin ages from the inside out and how supplements can help achieve healthy skin, clear skin with acne, address rosacea, vitiligo, melasma, and so much more.     TIMESTAMPS: 1:45 – Skin Health Starts From the Inside Out 2:10 – How Glycine Skin Was Founded by Immunologists 3:00 – Medical & Scientific Roots of the Brand 4:00 – Improving Energy, Inflammation & Quality of Life 5:00 – How Dr. Jen Discovered Glycine Skin 6:00 – Nutrition, Supplements & Skin Health Explained 7:00 – What Is Superoxide Dismutase (SOD)? 8:00 – Why SOD Is Called the "Enzyme of Life" 9:00 – Oxygen, Free Radicals & Cellular Damage 10:00 – How SOD Protects Cells From Oxidative Stress 11:00 – Antioxidant, Anti-Inflammatory & Immune Benefits 12:00 – How Internal Antioxidants Work 24/7 13:00 – Skin Diseases, Immunity & Inflammation 14:00 – Photoprotection, Pigmentation & Skin Clarity 15:00 – How Glycine Skin Supports Melasma & Vitiligo 16:00 – Immune Modulation vs Immune Stimulation 17:00 – Overview of Glycine Skin Supplement Options 18:00 – Pure Enzyme Formula: Who It's For 19:00 – Recovery, Inflammation & Athletic Performance 20:00 – Anti-Aging Formula: Skin Texture, Glow & Elasticity 21:00 – Skin Brightening Formula: Melasma & Hyperpigmentation 22:00 – Clinical Dosages vs Under-Dosed Supplements 23:00 – Acne, Laser Treatments & Pigmentation Rebound 24:00 – Seasonal Use: Brightening vs Anti-Aging 25:00 – Phospholipids, Brain Health & Energy 26:00 – Cognitive Benefits & Overall Wellness 27:00 – Gluten, Gliadin & Safety Explained 28:00 – Scientific Studies & Where to Learn More 29:00 – Why Long-Standing Supplements Matter More Than Trends     https://www.glisodin.com/ - Use Code DRJEN2026 for 20% off your order!   Instagram: @glisodin_skin   Watch this episode on The Radiance revealed YouTube Channel:     PRODUCTS / RESOURCES:   Follow Dr. Jen Haley on Instagram @drjenhaley - instagram.com/drjenhaley Connect on LinkedIn:  http://linkedin.com/in/jennifer-haley-md-faad-a4283b46 Book a consultation with Dr. Haley here:  https://app.minnect.com/expert/DrJenHaley Dr. Haley's favorite skincare:  https://www.alumiermd.com?code=5HUKRDKW Dr. Haley's favorite supplements (15% discount): https://us.fullscript.com/welcome/hhaley   #radiancerevealedpodcast

Low Tox Life
465. The practical path to a Brain that Breathes with Jodi Wilson

Low Tox Life

Play Episode Listen Later Jan 25, 2026 55:19


If you want more brain space and less pressure in your day, this Low Tox Life episode is for you.I am joined by author Jodi Wilson, who wrote her new book “A Brain That Breathes” after years of writing, parenting, and pushing through burnout. Jodi noticed something big - modern life asks too much from our brains. We are always reachable, always scrolling, and always deciding. No wonder we feel foggy, edgy, and done.Jodi shares a powerful idea: we do not always need more tools or more “self-care and it definitely does not need to ‘cost us more' to practise it.” We often need subtraction. She calls it breathing space - small moments of downtime that help your nervous system settle and help your brain declutter.You will hear about “soft fascination,” a science-backed reset that happens when your attention is gently held by simple things - a walk without headphones, the ocean, trees, clouds, shower water, or bubbles in the sink. In these moments, your brain gets space to sort thoughts, ease stress, and untangle stuck ideas. Jodi also shares easy ways to protect your mornings, create a calmer evening routine, and use a deep sigh as a fast reset.This is not about fixing yourself. It is about coming home to what you need today - and choosing what is enough.I hope you love it as much as I love that this is out in the world for you, Alexx Stuart, your host xFancy a few more podcasts we've done over the years, related to this one?Show #367 Burn Out and Powering Life Differently with Dr Neha SangwanShow #390 Somatics: How to Make your Journey Real and True with Irene Lyon, MSc.Show #405 It's not you, it's your nervous system: How to tell the difference with Jessica MaguireShow #464. Too busy or scared to feel everything? Dr Jenn Rapkin explains the health benefits we're missing and how to reconnect.Want to learn more about this week's guest? Website: Practisingsimplicity.substack.comInstagram: https://www.instagram.com/practisingsimplicity Book: https://bit.ly/4r7j4fU Thank you to this month's show partners for joining us to help you make your low tox swaps! @jules_stonesoup has been teaching people to cook joyfully and with foods that cultivate health and vitality for over 15 years. Head to bit.ly/joyfulcook20 and use code LOWTOXLIFE to do Jules' next program at 20% off + 2 friends do it free! 20mins a week, 6 months, for less overwhelm, waste and cost, and increased vitality, variety and deliciousness. Sold!@ediblebeautyau is here with 30% off site-wide! My top reco's? The Super Stem Cell concentrate serum, Exotic goddess serum, Enzyme peel or microexfoliant for some healthy skin regeneration! Or the new up-sized sunscreen in 200g to carry you the rest of summer. Enjoy! CODE: LOWTOXLIFE. https://bit.ly/Edible_Beauty@ausclimate is our major partner giving you 10% off their range for the whole of 2026, with brilliant Winix Air Purifiers, the best Dehumidifiers I've ever used and their new energy-efficient heating, air-circulating and cooling range. code LOWTOXLIFE (also works over and above their sales - pro tip!) https://bit.ly/ShopAusclimateBe sure to join me on Instagram @lowtoxlife and tag me with your shares and AHAs if something resonated! I love to see your thoughts, genuinely! Hosted on Acast. See acast.com/privacy for more information.

The Poultry Nutrition Blackbelt Podcast
Dr. Sami Dridi: Beta Mannans Impact on Poultry | Ep. 136

The Poultry Nutrition Blackbelt Podcast

Play Episode Listen Later Jan 21, 2026 12:47


In this episode of The Poultry Nutrition Blackbelt Podcast, Dr. Sami Dridi from the University of Arkansas explains the molecular and physiological impact of beta mannan on poultry health and performance. He breaks down how beta mannan triggers inflammation, affects gut integrity, and reduces feed efficiency, and he shares research on how beta mannanase can counter these challenges. Listen now on all major platforms!"Beta mannan creates physiological, immunological, and metabolic challenges that influence overall nutrient use and bird performance."Meet the guest: Dr. Sami Dridi is a Professor at the University of Arkansas, leading the Laboratory of Avian Endocrinology and Molecular Genetics within the Center of Excellence for Poultry Science. His research explores heat stress responses, intestinal integrity, and metabolic disorders such as muscle myopathies in poultry. His recent work examines beta mannan and beta mannanase effects on performance and gut health. Listen to this Poultry Nutrition Blackbelt Podcast episode with Dr. Sami Dridi on all major platforms.Liked this one? Don't stop now — Here's what we think you'll love!What you'll learn:(00:00) Highlight(01:39) Introduction(03:45) Beta mannan effects(05:19) Gut integrity impact(06:57) Enzyme function(07:46) Performance results(10:50) Future applications(13:07) Closing thoughtsThe Poultry Nutrition Blackbelt Podcast is trusted and supported by innovative companies like: BASF* Kemin* Fortiva- Anitox- Poultry Science Association- DietForge

Low Tox Life
464. Too busy or scared to feel everything? Dr Jenn Rapkin explains the health benefits we're missing and how to reconnect.

Low Tox Life

Play Episode Listen Later Jan 18, 2026 63:12


What if your body has been trying to get your attention - through tension, numbness, or stress - but you've been too busy to listen?Enter our first show of 2026 to help usher a new chapter in literally feeling the feels.Dr. Jenn Rapkin is a naturopathic doctor who helps people reconnect with their feelings through body-based care. In this episode, we talk about why many of us learned to "push through" emotions - and what that can cost our health. Jenn shares simple ways to notice feelings in the body (like "hard bubbles" in the chest) and why emotions come in waves. You'll learn gentle steps to build emotional strength, without forcing anything. Jenn also explains when it's best to get professional support, especially if trauma is part of your story. This is a kind, practical chat for real life.Fancy a few more shows related to this one?Show #447 The Biology of Trauma: Uncover, Understand, and Heal with Dr. Aimie ApigianShow #408 What would it look like for you to be completely recovered? Thought Field Therapy with Dr Robert BrayShow #378 Stop trying to ‘control' your emotions, and here's why… with Cedric BertelliShow #240 – Dr Carrie Rigoni: Vagus Nerve Health for Babies, Kids, and ParentsWant to learn more about this week's guest? www.drjennrapkin.com https://www.linkedin.com/in/jenn-rapkin-n-d-42a09ab5/ https://www.facebook.com/profile.php?id=61575991456912 https://www.instagram.com/drjennrapkin/ Book: https://bit.ly/3ZcgtFi Thank you to this month's show partners for joining us to help you make your low tox swaps! @jules_stonesoup has been teaching people to cook joyfully and with foods that cultivate health and vitality for over 15 years. Head to bit.ly/joyfulcook20 and use code LOWTOXLIFE to do Jules' next course at 20% off + 2 friends do it free! 20mins a week, 6 months, for less overwhelm, waste and cost, and increased vitality, variety and deliciousness. Sold! https://bit.ly/joyfulcook20 Our first podcast partner offer of the year with @ediblebeautyau - 30% off site-wide! My top reco's? The Super Stem Cell concentrate serum, Exotic goddess serum, Enzyme peel or microexfoliant for some healthy skin regeneration! Or the new up-sized sunscreen in 200g to carry you the rest of summer. Enjoy! CODE: LOWTOXLIFE. https://bit.ly/Edible_Beauty@ausclimate is our major partner giving you 10% off their range for the whole of 2025, with brilliant Winix Air Purifiers, the best Dehumidifiers I've ever used and their new energy-efficient heating, air-circulating and cooling range. code LOWTOXLIFE (also works over and above their sales - pro tip!) https://bit.ly/ShopAusclimateBe sure to join me on Instagram @lowtoxlife and tag me with your shares and AHAs if something resonated! I love to see your thoughts, genuinely! Want to support the Low Tox Life podcast? Free option: Leave a 5 star review wherever you listen to Low Tox Life - thanks SO much! Paid + Member PERKS: Join the Low Tox Club - monthly practitioner live masterclasses, a suite of low tox store discounts from around the world and the most supportive and lovely chat group on all low tox topics on the internet: Check it out and join here for just the price of a coffee per month! Hosted on Acast. See acast.com/privacy for more information.

Rare Disease Discussions
Chapter 5: Current Treatment Landscape and Limitations

Rare Disease Discussions

Play Episode Listen Later Dec 21, 2025 9:01


Nicola Longo MD, PhD, and Mark Roberts, MDDrs. Longo and Roberts discuss the current status of gene therapies in rare neuromuscular disorders in this eight-part podcast series. This is derived from the symposium that was presented at WORLDSymposium 2025 in San Diego, California on February 4th-7th 2025 and is intended for healthcare professionals only.This podcast includes information about investigational compounds that do not yet have a regulatory approval or authorization for a specific indication. The safety and efficacy of the agents under investigation have not been established and contents of this podcast shall not be used in any manner to directly or indirectly promote or sell the product for unapproved uses.The views, thoughts, and opinions expressed in this presentation belong solely to the author and are subject to change without notice. The contents of this presentation do not constitute an endorsement of any product or indication by Astellas. In this part, Dr. Longo will discuss the current treatment landscape and limitations in lysosomal disorders.Nicola Longo MD, PhDWhat I want to do today, is just place gene replacement therapy within the current landscape of lysosomal storage disorder treatment therapy. Gene therapy obviously has the potential of treating lysosomal disorder to correct the root cause of lysosomal storage disorder. The gene is defective, and what happen is that you can potentially either fix the gene or bypass the lack of the genetic product. But there are already therapies that are existing and are functioning. Obviously, in many cases, the lysosomal disorder is caused by defective production of an enzyme, which is defective.We can either replace the enzyme with enzyme replacement therapy, or provide chaperone for specific mutations that retain the synthesis of the enzyme, that however is not very functional. Another avenue that it is being reported is the utilization of substrate reduction therapy. A substrate accumulates, you prevent the synthesis of the substrate to reduce the accumulation of toxic material. What we know now is that this is not enough to produce many lysosomal disorders. In many cases, the lysosomal disorder result sometime in impairment of intracellular trafficking, and sometime in the function of other organelles.At the end, it results in the activation of the macrophagic system and inflammation. Already we have some therapy acting at this level. The end result of lysosomal storage disorder, there will be cell suffering and cell death, leading to a progression of the disease, and morbidity and mortality. Now, what therapy do we have available already? Obviously, hematopoietic stem cell transplantation has been around for quite some time.It has been the same thing that we do with gene therapy, except that instead of reintroducing the gene of the subject, we place gene of a subject who is not affected of the disease. This therapy has been proven effective in cases of MPS-1 and alpha-mannosidosis. But in many cases this has to be given way before symptoms start to be affected.Enzyme replacement therapy has been around for quite some time, starting with Gaucher disease, and now that it is available for a list of diseases that are there, so it's like Fabry, Gaucher, Pompe, different types of mucopolysaccharidosis, alpha-mannosidosis, acid lipase deficiency, 1 neuronal ceroid lipofuscinosis, and Niemann-Pick type A and B.Obviously the advantage of this therapy, they give back the enzyme that it is defective. But the disadvantage that many time they cannot enter specialized areas such as the brain. There is already the second generation of enzyme replacement therapy that it is available. With this second generation, some of the newer drugs are more effective in terms of cellular uptake, or in terms of having a prolonged half-life and prolonged activity.Then there are pharmacological chaperone therapy, and the one which is FDA approved is migalastat for Fabry disease, under study is ambroxol for Gaucher disease. The disadvantage of this therapy that only a selected number of mutations respond to this therapy.Substrate reduction therapy has been introduced for Gaucher disease many years ago with miglustat, and it was followed by eliglustat. Both of them are effective, and some of them more effective than other, simply because of the fewer side effects of eliglustat as compared to miglustat. But at the same time, eliglustat does not pass the blood brain barrier.Finally, the newer agents that are already administered, N-acetyl-L-leucine and arimoclomol, both approved for Niemann-Pick type C, they act more on the downstream effect of the lysosomal storage disorder, either by stabilizing neuronal cell activity or by reducing the inflammation that is present in the brain.In the next part, Dr. Longo will discuss gene replacement therapy in lysosomal disorders.

The Aesthetic Report
December Overview (Minisode)

The Aesthetic Report

Play Episode Listen Later Dec 4, 2025 6:09 Transcription Available


Connect with us via text! It's finally here -- the end of the year -- and with it comes a stacked calendar for DERMASCOPE. Check out the December issue for the 2025 cover contest winner reveal and other educational goodies, register for "Peeling Explained: Chemical, Enzyme, Physical & Biological Approaches", a webinar presented by Dr. Schrammek USA, and help us close out our anniversary year and season five of the podcast. Thanks for celebrating with us, and don't forget to take advantage of all December has to offer! Follow DERMASCOPE:Instagram: @dermascopeFacebook: facebook.com/dermascopePinterest: @dermascopeTikTok: @dermascopeAdditional Links:Visit our website.Learn more about this podcast.Subscribe to the magazine.Read the December 2025 issue. Register for the Schrammek webinar. 

Science@UH
Can Inhibiting 15-PGDH Enzyme Protect Against Cognitive Decline in TBI Patients?

Science@UH

Play Episode Listen Later Nov 20, 2025 16:55


Join Dr. Daniel Simon as he explores the groundbreaking collaboration between Dr. Sanford Markowitz and Dr. Andrew Pieper. Discover how their combined expertise in cancer genetics and psychiatry is leading to innovative approaches that tackle Alzheimer's and traumatic brain injury, providing hope and insight to those affected by these devastating conditions.Learn more about Sanford Markowitz, MD, PhDLearn more about Andrew Pieper, MD, PhDNEW! View our Science@UH video podcast on YouTubeLearn more about the University Hospitals Research & Education Institute

The Cabral Concept
3558: Celiac & Digestive Enzyme, CBD Gummies & Joint Pain, DHEA & Acne, Clothing & Polyurethane, Afternoon Brain Fog (HouseCall)

The Cabral Concept

Play Episode Listen Later Nov 2, 2025 15:09


Thank you for joining us for our 2nd Cabral HouseCall of the weekend!   I'm looking forward to sharing with you some of our community's questions that have come in over the past few weeks…   Lynette: I have Celiac Disease and worry about cross-contamination when eating at restaurants or friends' homes. People have suggested taking a gluten digestive enzyme, but I don't want to digest gluten. Is there anything I can take prior to eating that would rid my body of gluten, should I unknowingly come into contact with it? I'm a "silent celiac" so don't experience immediate GI upset, but instead suffer joint pain, headaches, and skin issues afterward. Living gluten-free out in the world is tough, so any suggestions to make things easier and safer are appreciated. Thanks!                                          Anonymous: I received a complimentary bottle of CBD Gummies -- thanks! Are there any contraindications with taking them? I'm thinking about them for my older parents, who are on the typical American old-age pharmaceuticals, including high blood pressure medication, statins, and Gabapentin. Will the gummies help with general aches and pains? Thank you.                                                                                                                                                                                            Sarah: I did labs through Equilife and found that my testosterone and DHEA were significantly low. For reference, I am a 49 year-old perimenopausal female. I started using about 8 mg of DHEA orally daily. (at that point I had 25 mg capsules I was splitting) Within three days of starting I had some longer lasting cystic acne on my face starting to appear. I gave it a few weeks to resolve and then began 25 mg of 7 keto DHEA daily and have had no acne breakouts at all. On my call with my IHP through Equilife to follow up from the labs, I was told that 7 keto DHEA is the same as regular DHEA and is likely just a marketing tool. Can you tell me why I reacted significantly different to the 7 keto DHEA? Several companies, some quite reputable sell it, do you recommend it in my case?                                              Anonymous: Hello, I appreciate the work you do, and would like your input to help me make a purchasing decision. I wanted to buy some Japanese selvedge jeans and notice they contain 2% Polyurethane. I had difficulty establishing whether the use of Polyurethane in clothing is harmful and wanted to know if you could direct me to resources which could provide me with more insight on this topic? Please let me know.                                                                                               Anonymous: I struggle with brain fog and low energy in the afternoons, even though I get enough sleep. Could this be related to blood sugar balance, and if so, what are some easy ways to stabilize it throughout the day?               Thank you for tuning into this weekend's Cabral HouseCalls and be sure to check back tomorrow for our Mindset & Motivation Monday show to get your week started off right! - - - Show Notes and Resources: StephenCabral.com/3558 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!  

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Les matins
La double vie d'une enzyme du métabolisme des graisses

Les matins

Play Episode Listen Later Oct 28, 2025 5:08


durée : 00:05:08 - Avec sciences - par : Alexandra Delbot - Une nouvelle étude montre que l'enzyme HSL, connue pour libérer les graisses, agit aussi le stockage des lipides. Selon sa localisation, elle jouerait des rôles différents. Une découverte qui permet une meilleure compréhension de la lipodystrophie et de l'obésité.

Have You Herd? AABP PodCasts
Epi. 257 – The Effect of Salmonella Vaccination on Salmonella Dublin Blood Enzyme-linked Immunosorbent Assay Results

Have You Herd? AABP PodCasts

Play Episode Listen Later Oct 27, 2025 26:21


AABP executive Director Dr. Fred Gingrich reviews a paper published in The Bovine Practitioner with two of the authors. Joining today are Dr. Greg Habing, professor in the Department of Preventive Medicine at The Ohio State University College of Veterinary Medicine, and Dr. Emily Nogay, clinical assistant professor at The Ohio State University Large Animal Ambulatory Services.  Salmonella Dublin is a host-adapted and zoonotic pathogen affecting many dairy farms. It can be associated with high morbidity and mortality and is often multi-drug resistant which elevates its importance to dairy farmers and veterinarians. Surveillance and diagnostics are an important aspect of managing diseases in our herds. Nogay reviews available diagnostic tests and the advantages and disadvantages of each one. The ELISA test has a sensitivity of 65%, but is used to screen herds for the disease. The objective of this study was to determine if the four U.S. commercially licensed Salmonella vaccines would result in a positive Salmonella Dublin ELISA test result.  We walk through the results of the paper and discuss some of the findings, including the impact of the vaccines on the serum ELISA results and some potential reasons for the ELISA results after vaccination. Habing discusses future opportunities for research on this disease, including the need for better diagnostic tests, including a PCR test to screen herds.  AABP's peer-reviewed journal, The Bovine Practitioner, publishes original research studies, reviews, case series, and case reports intended to provide clinically relevant research to private practicing veterinarians. It is an open access journal and there are no publication fees for submitting authors. Read more about the journal at this link.  The effect of Salmonella vaccination on Salmonella Dublin blood enzyme-linked immunosorbent assay results. Bov Pract. 2025;59(2), 53-60. https://doi.org/10.21423/bpj20259266

PNAS Science Sessions
Enzyme linked with brain evolution

PNAS Science Sessions

Play Episode Listen Later Oct 13, 2025 10:42


Implications of a mutation in modern humans Science Sessions are brief conversations with cutting-edge researchers, National Academy members, and policymakers as they discuss topics relevant to today's scientific community. Learn the behind-the-scenes story of work published in the Proceedings of the National Academy of Sciences (PNAS), plus a broad range of scientific news about discoveries that affect the world around us. In this episode, Xiangchun Ju and Svante Pääbo explore the evolutionary implications of a mutation that separates modern humans from ancestral hominins. In this episode, we cover: •[00:00]  •[01:22] Neurobiologist Xiangchun Ju introduces the enzyme adenylosuccinate lyase, or ADSL, and its role in the synthesis of purine. •[02:09] Evolutionary anthropologist Svante Pääbo talks about the discovery of the A429V mutation, which is present in modern humans but not Neanderthals or Denisovans. •[03:38] Ju and Pääbo talk about the methods to humanize mice in order to study the evolutionary importance of the A429V mutation. •[05:04] They explain the results of the behavioral studies of the humanized mice. •[06:27] Pääbo explores the takeaways from the study.  •[08:05] He contextualizes the study alongside other studies of modern human development. •[09:17] Pääbo and Ju list the caveats and limitations of the study. •[10:14] Conclusion. About Our Guests: Xiangchun Ju Postdoctoral scholar Okinawa Institute of Science and Technology Svante Pääbo Director Max Planck Institute for Evolutionary Anthropology View related content here: https://www.pnas.org/doi/10.1073/pnas.2508540122 Follow us on Spotify, Apple Podcasts, or wherever you get your podcasts for more captivating discussions on scientific breakthroughs! Visit Science Sessions on PNAS.org: https://www.pnas.org/about/science-sessions-podcast  Follow PNAS: Twitter/X Facebook LinkedIn YouTube Sign up for the PNAS Highlights newsletter

The Medbullets Step 1 Podcast
Pharmacology | Enzyme Kinetics

The Medbullets Step 1 Podcast

Play Episode Listen Later Oct 5, 2025 10:38


In this episode, we review the high-yield topic of⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Enzyme Kinetics ⁠from the Pharmacology section.Follow⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Medbullets⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbullets

Rising into Mindful Motherhood | Fertility Wisdom
#155 | How One Overlooked Enzyme Disrupts Estrogen, Optimal Fertility and Your Chances of Getting Pregnant

Rising into Mindful Motherhood | Fertility Wisdom

Play Episode Listen Later Sep 18, 2025 5:45 Transcription Available


Could this overlooked gut enzyme be the reason you're still not pregnant?Most women have never even heard of this enzyme, so if you've been chasing answers without success, this hidden factor might finally explain what's going on.In this episode, you'll...-Understand what beta glucuronidase is and why it matters for fertility.-Discover the symptoms and lifestyle factors that increase your risk of imbalance.-Learn simple, practical ways to support gut health, estrogen detox, and better hormone balance.Tune in now to uncover how rebalancing this one enzyme could open the door to the healthy pregnancy you've been longing for.

The Ultimate Human with Gary Brecka
187. Wade Lightheart & Matt Gallant: Enzyme Fasting, Magnesium Science, NAD & Brain Training

The Ultimate Human with Gary Brecka

Play Episode Listen Later Jul 29, 2025 92:35


What if everything you think you know about supplementation is backwards, and the real secret lies in the enzymatic processes that bodybuilders discovered decades ago? I sit down with Wade Lightheart and Matt Gallant from BiOptimizers who blow my mind with their lab research shows 1200% more amino acid absorption when you combine the right enzymes with protein, why magnesium deficiency is literally rewiring your stress response, and how fixing gut dysfunction - which I've seen in every single anxiety patient among my 160,000 cases - transforms everything from brain fog to systemic inflammation. BIOPTIMIZERS: “ULTIMATE” FOR 10% OFF: ⁠https://bit.ly/4inFfd7 Join the Ultimate Human VIP community for Gary Brecka's proven wellness protocols! https://bit.ly/4ai0Xwg Get Matt Gallant and Wade Lightheart's book, “The Ultimate Nutrition Bible“ here http://bit.ly/4fcvRsC   Listen to "BIOptimizers Awesome Health Podcast" on all your favorite platforms! Website http://bit.ly/457Ju7x Apple Podcasts http://bit.ly/3J63qjP   Connect with Wade Lightheart Website http://bit.ly/4l6CApl YouTube http://bit.ly/3INtZu3 Instagram http://bit.ly/459xSRw TikTok http://bit.ly/46xKt3A Facebook https://bit.ly/3J59Xv8  X http://bit.ly/4kXGtgh LinkedIn http://bit.ly/4mgNNoa Connect with Matt Gallant YouTube http://bit.ly/4oc5nLE Instagram http://bit.ly/3U2DBDF Facebook http://bit.ly/4kUa75P X http://bit.ly/475TbGd LinkedIn http://bit.ly/3UFY29D Thank you to our partners H2TABS: “ULTIMATE10” FOR 10% OFF: https://bit.ly/4hMNdgg BODYHEALTH: “ULTIMATE20” FOR 20% OFF: http://bit.ly/4e5IjsV BAJA GOLD: "ULTIMATE10" FOR 10% OFF: https://bit.ly/3WSBqUa EIGHT SLEEP: SAVE $350 ON THE POD 4 ULTRA WITH CODE “GARY”: https://bit.ly/3WkLd6E COLD LIFE: THE ULTIMATE HUMAN PLUNGE: https://bit.ly/4eULUKp WHOOP: JOIN AND GET 1 FREE MONTH!: https://bit.ly/3VQ0nzW MASA CHIPS: 20% OFF FIRST ORDER: https://bit.ly/40LVY4y VANDY: “ULTIMATE20” FOR 20% OFF: https://bit.ly/49Qr7WE A-GAME: “ULTIMATE15” FOR 15% OFF: http://bit.ly/4kek1ij HAPBEE: FEEL BETTER & PERFORM AT YOUR BEST: https://bit.ly/4a6glfo CARAWAY: “ULTIMATE” FOR 10% OFF: https://bit.ly/3Q1VmkC RHO NUTRITION: “ULTIMATE15” FOR 15% OFF: https://bit.ly/44fFza0 HEALF: 10% OFF YOUR ORDER: https://bit.ly/41HJg6S GO PUFF: GET YOUR FAVORITE SNACK!  ⁠http://bit.ly/4obIFDC⁠ GENETIC TEST: ⁠https://bit.ly/3Yg1Uk9 Connect with Gary Brecka Instagram https://bit.ly/3RPpnFs TikTok https://bit.ly/4coJ8fo YouTube ⁠https://bit.ly/3RPQYX8 X https://bit.ly/3Opc8tf Facebook https://bit.ly/464VA1H LinkedIn https://bit.ly/4hH7Ri2 Website https://bit.ly/4eLDbdU Merch https://bit.ly/4aBpOM1 Newsletter https://bit.ly/47ejrws Ask Gary https://bit.ly/3PEAJuG Timestamps 00:00 Intro 02:36 Creation of Bio Optimizers 12:14 Disruption of Genetic Tendency 14:55 Importance of Taking Digestive Enzymes 26:21 Symptoms of Magnesium & Other Nutrient Deficiencies 32:42 Fixing One's Digestion Before Starting Supplementation 42:13 Concept of NanoVi Machine 31:43 Starting Your Supplementation Journey 50:55 Going Back to Taking Whole Foods 52:29 Gut-Brain Connection 1:02:29 What's Next for Matt and Wade? 1:08:49 Human Optimizing 10-Day Experience 1:15:16 Experience on Different Types of Brain Frequencies  1:17:15 What does it mean to you to be an “Ultimate Human?”  The Ultimate Human with Gary Brecka Podcast is for general informational purposes only and does not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast or materials linked from this podcast is at the user's own risk. The Content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professionals for any such conditions. Learn more about your ad choices. Visit megaphone.fm/adchoices

Dr. Joseph Mercola - Take Control of Your Health
The Egg White Secret to Lowering Blood Pressure - AI Podcast

Dr. Joseph Mercola - Take Control of Your Health

Play Episode Listen Later Jul 8, 2025 9:03


Story at-a-glance Egg white proteins naturally lower blood pressure by releasing peptides that relax blood vessels and boost nitric oxide production without pharmaceutical side effects Research shows egg whites reduced systolic blood pressure by 18 points in just nine days by supporting the body's natural circulation mechanisms Enzyme-treated egg whites maintain blood pressure benefits while eliminating allergic reactions, making them a safe option for people allergic to eggs Pasture-raised, low-linoleic acid eggs provide optimal cardiovascular benefits, while conventional factory-farmed eggs cause inflammation that counteracts many positive effects Combining egg whites with nitric oxide-boosting foods like beets and glycine-rich bone broth maximizes their blood pressure-lowering effects and overall benefits naturally  

Late Confirmation by CoinDesk
Are Most Tokens Quietly Crashing? | Markets Daily

Late Confirmation by CoinDesk

Play Episode Listen Later May 5, 2025 14:24


The latest price moves and insights with Jennifer Sanasie and Enzyme founder Mona El Isa.To get the show every day, follow the podcast here.Enzyme founder Mona El Isa joins CoinDesk to discuss the current "strange bear market" in the crypto space, with a few assets remaining close to their highs while the broader market experiences significant underperformance. Plus, potential of a DeFi summer and the state of M&A in the crypto industry.This content should not be construed or relied upon as investment advice. It is for entertainment and general information purposes.-This episode was hosted by Jennifer Sanasie. “Markets Daily” is produced by Jennifer Sanasie and edited by Victor Chen.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.