Stem Cell Channel (Audio)

Can we not only live longer but better, healthier lives? Robert A.J. Signer and Shiri Gur-Cohen describe how stem cell research may hold the key to longevity. Centenarian Stanley Clothier shares his secrets to a long life and artist Amy Burkman celebrates the connection between art, science, and her own health journey. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39722]

Why explore stem cells in space when we have the comfort of Earth's laboratories? Join Robert A.J. Signer, Ph.D., alongside Catriona Jamieson, M.D., Ph.D., and Alysson Muotri, Ph.D., as they delve into the untapped potential of space experiments for expediting medical breakthroughs. Patient advocate Alexandria Allen offers a poignant narrative, revealing the profound impact such research has had on her personal health journey. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39733]

Medical advances have significantly improved the survival of preterm babies and term neonates with brain injuries due to environmental hypoxia or genetic causes. Anca Pasca, M.D., shares her work to understand the molecular mechanisms underlying neurodevelopmental disorders associated with fetal and neonatal brain injury. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39453]

Explore cutting-edge research at the intersection of neuroscience, space exploration, and medical innovation. Researchers discuss revolutionary experiments with brain organoids cultivated from stem cells, conducted both in terrestrial labs and aboard the International Space Station. They investigate accelerated aging, neuroprotective agents, and potential treatments for conditions like Alzheimer's and ALS. The dialogue also delves into the transformative impact of space environments on scientific discoveries, from understanding bacterial growth to developing novel therapies. Through collaborative efforts, they strive to revolutionize healthcare, offering hope for patients and pushing the boundaries of human knowledge. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39632]

Marking the one-year anniversary of the Global Astrobiotechnology Hub, an esteemed panel convenes to envision the future of space exploration and stem cell research. Central to their discussion is the imperative to enhance accessibility and expedite scientific inquiry in space. They advocate for a shift towards establishing regular access to space, enabling frequent dispatches of payloads and experiments. They highlight the pressing need to advance technology to democratize space research, opening doors for nontraditional researchers from industry, academia, and beyond. They emphasize the significance of scientist-astronauts who possess a nuanced understanding of research methodologies. Emphasizing the importance of public engagement, they underscore the need to disseminate research findings widely and mentor the upcoming generation of scientists. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39528]

Elena Ezhkova, Ph.D., discusses the role of Merkel cells in touch sensation and their connection to nerves. She shares research on skin cancer formation, focusing on the PRC1 complex's impact on gene expression. Ezhkova also investigates epithelial-to-mesenchymal transition (EMT), finding it contributes to cancer spread. Ezhkova offers insights for potential cancer treatments. Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 38335]

Amander Clark, Ph.D., delves into crafting artificial ovaries for fertility and aging research. She stresses the importance of diversity in stem cell studies to ensure comprehensive findings. By assembling ovarian models from various genetic backgrounds, her team aims for inclusive representation in biomedical research, potentially offering insights into reproductive health and disease. Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 38334]

Hanna Mikkola, M.D., Ph.D., shares her work in hematopoietic stem cells (HSCs) and their complex renewal process. Her research aims to unravel these cells' behavior in mice and humans, offering potential insights for future medical advancements. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39258]

Mathew Blurton-Jones presents CRISPR-based interventions for a rare brain disorder in mice by substituting defective brain cells with healthy ones. He details experiments demonstrating the efficacy of corrected cells in mitigating brain pathologies. Blurton-Jones emphasizes the need for cautious translation to human trials, advocating gradual cell replacement to preempt potential adverse effects. Additionally, he delves into the implications of microglia in Alzheimer's disease progression and explores potential interconnections among various neurodegenerative conditions. Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 38333]

Anna Beaudin, Ph.D., delves into the intricacies of how prenatal inflammation impacts the immune system's blueprint, shaping its long-term function. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39257]

CIRM-funded Alpha Stem Cell Clinics are a network of California medical centers that specialize in delivering stem cell clinical trials to patients. In this fascinating panel, clinic directors discuss advanced treatments, therapies like gene editing, and sharing knowledge and creating networks across the country for better patient care. Featuring: Geoffrey Lomax, Dr.PH California Institute for Regenerative Medicine Esther and Andrew Schorr Patient Advocates Sandra Dillon Cancer Survivor and Stem Cell Champion Catriona Jamieson, M.D., Ph.D. UC San Diego Mehrdad Abedi, M.D. UC Davis Daniela A. Bota, M.D., Ph.D. UC Irvine Sheila Chari, Ph.D. Cell Press Leo D. Wang, M.D., Ph.D. City of Hope National Medical Center Mark Walters, M.D. University of California, San Francisco Thomas Buchanan, M.D. University of Southern California Michael Lewis, M.D. Cedars Sinai Noah Federman, M.D. UCLA Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 39070]

Experts discuss the immense potential of conducting experiments and manufacturing goods in space. They explore how this could enhance our understanding of health issues, unveil new discoveries, and produce innovative technology for use on Earth. The conversation encompasses collaborations between various industries and scientists, aiming to explore the distinct conditions in space to enhance life for all. Featuring: Catriona Jamieson, M.D., Ph.D. UC San Diego Jana Stoudemire, M.Bio. Axiom Space Alain Berinstain, Ph.D. Space Tango Marc Giulianotti, Ph.D. Sierra Space Kevin Engelbert, M.S.F. NASA Michael Roberts, Ph.D. CASIS Arun Sharma, Ph.D. Cedars Sinai Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39072]

Clive Svendsen, Ph.D., leads groundbreaking experiments using stem cell transplants, uncovering unexpected findings. These trials aimed at improving ALS treatments, revealed higher success with upper motor neuron transplants compared to spinal cord methods. Svendsen's exploration of cortical transplants hints at a potential breakthrough. Moreover, his study of stem cell behavior in space opens doors to exciting medical advancements. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39068]

Hans Clevers, M.D., Ph.D., shares his research at the intersection of medicine and biology. Clevers discusses revolutionary advances in personalized medicine, where patient-specific treatments can be developed by studying small samples of patients' tissues. He explores the role of specialized cells known as "best for cells" in gastrointestinal health, shedding light on how they may help fight infections. Additionally, he highlights how mini-organs, or organoids, grown in the lab help us understand complex cellular functions and diseases. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39066]

Carla Kim, Ph.D., explains how aging impacts lung cell biology and its potential to reshape our understanding of diseases, including lung cancer. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39254]

Siddhartha Jaiswal, M.D., Ph.D., discusses clonal hematopoiesis and its impact on aging and diseases. Jaiswal highlights the role of genetic variations, focusing on a specific gene, TET2, and its link to clonal expansion. He explains that certain genetic variations can slow clonal expansion, potentially offering insights into treatments or interventions to mitigate its effects. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39260]

Astronaut Peggy Whitson, Ph.D., and Lisa Carnell, Ph.D., discuss various aspects of space exploration, life in microgravity, and the future of space science and research. They delve into the challenges astronauts face, from taste differences in space to innovative 3D printing solutions. The conversation also highlights the importance of stem cell research, personalized medicine, and drug development in space. Whitson's unique perspective offers insights into the awe-inspiring views of Earth from space and the collective responsibility to protect our planet. This thought-provoking discussion exemplifies the intersection of science, space exploration, and the promise of a future beyond our planet. Series: "Stem Cell Channel" [Science] [Show ID: 39073]

Ronald DePinho, M.D., explains how telomerase, typically linked to telomere maintenance, serves as a transcriptional co-activator in the brain. Epigenetic repression of TERT, the gene for telomerase, occurs with aging, contributing to aging hallmarks like cellular senescence and inflammation. DePinho's team developed a compound that reactivates TERT, which, when administered to mice, reverses age-related changes. It restores cognitive function, reduces amyloid plaque, and alleviates inflammation. This suggests that maintaining TERT levels can counteract age-related cognitive decline and neurodegeneration, offering potential for treating neurodegenerative diseases like Alzheimer's. DePinho's work expands our understanding of telomerase's multifaceted role in aging and neurodegeneration, holding promise for interventions against these age-related processes. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39071]

Leonard Zon, M.D., discusses cutting-edge research on the intricate relationship between macrophages, stem cells, and the development of leukemia using the zebrafish model. He delves into the fascinating interactions between these cell types, highlighting the role of a "don't eat me" signal and the influence of the leukemic niche. Through cellular barcoding and single-cell RNA sequencing, he unveils a potential therapeutic target which may offer promising insights into treating leukemia by disrupting the stromal activities that support it. Zon showcases the power of zebrafish models in advancing our understanding of hematopoiesis and cancer, promising new avenues for research and treatment. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39064]

Are you curious about the future of medical treatments and how they might impact your health? Malcolm Moos, Jr., M.D., Ph.D., shares how cellular therapies are revolutionizing medical treatments. Explore how cells hold the potential to provide new hope for individuals facing various health challenges. Delve into the concept of personalized medicine, discover how regulatory agencies are safeguarding patients' well-being, learn the science behind cell behavior and genetics, and how these processes influence innovative medical treatments and so much more. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38330]

Aparna Bhaduri, Ph.D., shares insights into human brain development and its intricate processes. Explore the intriguing reappearance of developmental cell elements in brain cancers like glioblastoma. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38329]

Toshihiro Kobayashi, Ph.D., presents his research on the mechanisms driving cell fate choices in early mammalian embryos. He also discusses the potential application of these principles in future regenerative medicine. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38328]

Joseph C. Wu, M.D., Ph.D., shares his pioneering research on cardiovascular disease mechanisms using patient-specific stem cells. Learn about accelerated drug discovery, "clinical trials in a dish," and precision medicine's impact on treatment. Explore genomics, stem cells, imaging, and more. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38327]

Elsy Buitrago-Delgado, Ph.D., shares how spatial analysis of RNA distribution during early mouse embryogenesis suggests that the first cell fate choice is made at the 4-cell stage. She also discusses how notch signaling regulates cell fate choices during early human development. Series: "Stem Cell Channel" [Science] [Show ID: 38888]

Paul A. Northcott, Ph.D., St. Jude Children's Research Hospital, shares his work in multi-omic bulk and single-cell approaches to decipher molecular landscapes and developmental origins of medulloblastoma. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38889]

Over 65 million people around the globe are affected by epilepsy. Jenny Hsieh's research explores the underlying causes and mechanisms of epilepsies. Using stem cell-based models, including patient-derived neurons, she investigates how genetic and environmental factors contribute to the development of these conditions and potential therapies. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38326]

While exercise helps us stay healthy, what is happening on the molecular level? Matthew A. Romero, Ph.D., shares his work to understand how muscle in general and other cells specifically are transcriptionally regulated by exercise and how this affects their general behavior and how this is impacted by diseases such as obesity. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39033]

Gaia Navarino shares her work on disorder-causing genetic mutations at the system, cellular and molecular level. With a focus on autism spectrum disorder, she explains techniques used to identify common pathophysiological mechanisms in ASD and how that could provide a framework for the development of effective pharmacological therapies. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38325]

Ali H. Brinvanlou, Ph.D., shares his work using in vitro attached human embryos and genome-edited synthetic embryos derived from human embryonic stem cells to learn the molecular, cellular, and embryological basis of early human development. Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 38324]

Have questions about publishing in academic journals? Sheila Chari, Ph.D., editor in chief of Cell Stem Cell, explains the process from pre-submission through publication. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38722]

Tim Fenton, Ph.D., University of Southampton, shares his work on the roles of APOBEC3 genes. Hear how he is investigating APOBEC regulation and function in keratinocytes. Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 38724]

How do visions and norms of scientific progress inform, encourage or constrain democratic governance of science? How do questions of warrant, purpose, and benefit get asked and answered? Andy Murray, Ph.D., sits down with Carrie Wolinetz, Ph.D., National Institutes of Health (NIH), Maria Millan, M.D, California Institute for Regenerative Medicine (CIRM, Derek Thompson, The Atlantic, and Sheila Jasanoff, J.D., Ph.D., Harvard University, to explore these questions and more. Series: "Stem Cell Channel" [Science] [Show ID: 38731]

How do we set practical policies that allow scientific discovery to thrive while keeping an eye to risks and benefits for all? Carrie Wolinetz, Ph.D., National Institutes of Health (NIH), looks at current and past policy and shares her insights on the democratic governance of science. Series: "Stem Cell Channel" [Science] [Show ID: 38745]

How do structures and practices of privatization and commercialization affect capacities for deliberating and defining limits? How do questions of purpose, desirability, and public good relate to the prioritization of commercialization and profit? What means, formal and informal, exist for setting limits or seeking alignment between public and private interests? Krishanu Saha, Ph.D, Rosemarie Garland-Thomson, Ph.D., Reuven Brandt, Ph.D., and J. Benjamin Hurlbut, Ph.D., engage in a lively discussion of cosmopolitan ethics. Series: "Stem Cell Channel" [Public Affairs] [Humanities] [Show ID: 38730]

How do research communities contend with controversial science? J. Benjamin Hurlbut, Ph.D., Arizona State University, Alysson Muotri, Ph.D., UC San Diego, Matthew Porteus, M.D., Ph.D., Stanford University, and Jacob (Yaqub) Hanna, M.D., Ph.D., Weizmann Institute of Science, explore controversial case studies and the limitations of scientific deliberation/dissent/ambivalence. Series: "Stem Cell Channel" [Health and Medicine] [Humanities] [Science] [Show ID: 38729]

The identity of somatic and pluripotent cells can be epigenetically reprogrammed and forced to adapt a new functional cell state by different methods and distinct combinations of exogenous factors. The aspiration to utilize such in vitro reprogrammed pluripotent and somatic cells for therapeutic purposes necessitates understanding of the mechanisms of reprogramming and differentiation and elucidating the extent of equivalence of the in vitro derived cells to their in vivo counterparts. Jacob (Yaqub) Hanna, M.D., Ph.D., presents his group's recent advances toward understanding these fundamental questions and further details ongoing efforts to generate developmentally unrestricted human naive pluripotent cells with embryonic and extra-embryonic developmental potential. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38323]

Systems neuroscience aims to understand how brain cells and circuits are organized to produce behavior in living organisms. Julio Martinez-Trujillo, M.D., Ph.D., shares his research studying how neurons interact with one another and other cell types within a circuit during ex vivo and in vivo conditions. He also looks to the future and discusses how stem cell technologies can provide unique access to study human circuits and new insights into the nervous system. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38322]

As a mechanical engineer, Jin-Hyung Shim, Ph.D. has a unique perspective on tissue and organ regeneration. He discusses the present and potential of 3D printed biomaterials. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38321]

Shiri Gur-Cohen, Ph.D., UC San Diego, explains how her lab studies how epithelial stem cells communicate with their vascular microenvironment to advance regeneration and combat metastatic diseases. Series: "Stem Cell Channel" [Education] [Show ID: 38409]

How can we better understand the earliest stages of human development? Jianping Fu, Ph.D., University of Michigan, discusses his work using stem cell-derived embryoids. Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 38320]

Alysson Muotri discusses modeling Pitt-Hopkins syndrome (PTHS) using stem cells and brain organoids. He shares how rescuing TCF4 expression with CRISPR-mediated epigenetic induction of AAV vector delivery provides a gateway for targeted therapeutics for PTHS and related conditions. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38516]

Thomas C. Südhof, M.D., Stanford University, discusses facets of the fundamental cell biology of ApoE and APP analyzed in stem cell-derived human neurons. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38405]