Podcasts about Pitzer

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Sermon by Rev. Tim Pitzer on June 23, 2024 at New Covenant Church in Anderson, SC. Scripture: Psalms 5 ncchurch.net Prayer for the Anxious Soul 1. Help by having the right approach 2: Help by seeing the character of God 3: Help by being led by God 4: Help by protection from God

Lessons From Pitzer's Gaza Solidarity Encampment https://www.yesmagazine.org/opinion/2024/06/13/college-student-palestine-gaza #peoplearerevolting twitter.com/peoplerevolting Peoplearerevolting.com movingtrainradio.com

Passenger rail advocates All Aboard Erie and the Lakeshore Rail Alliance are holding a Lakeshore Rail Summit in Erie, with officials from government, transportation and manufacturing in attendance. AAE's Brian Pitzer and Mark Restifo gave a preview.

On today's episode of the Coffee Break, Russ spoke first with Danielle about Focus on the Family's SeeLife24. And later on, Russ spoke with Jana Keen and Lynn Adams from Options Pregnancy.  The Coffee Break is the daily Christian talk and local events program on Hope Radio KCMI 97.1FM serving the Scottsbluff, NE area. Tune in for interviews with authors, musicians, pastors, and others in the Christian community and our local area! Visit our website: www.kcmifm.com Like us on Facebook: www.facebook.com/kcmifm

Please join us over at  JFK The Enduring Secret You Tube Channel for another gripping episode in our series entitled Mysteries of the Enduring Secret. Our newest mystery episode covers Commander William Bruce Pitzer. Commander Pitzer died October 29, 1966 and the cause of death was officially ruled a suicide. For those of you who are avid listeners of JFK The Enduring Secret podcast, you know that I produced an extensive podcast episode on this story. It's episode 98 of JFK The Enduring Secret. Well, now, on our JFK Enduring Secret You Tube Channel, Mysteries of the Enduring Secret Series, we bring to you an interview by Rick Russo and myself with William Pitzer's nephew, Bruce Fernandez . Commander Pitzer supposedly died of a self-inflicted gun shot wound to the right temple. Many still believe it was murder and the evidence weighs heavy on that side of the scale…that it was indeed murder. Commander Pitzer was in charge of the Educational Television Division at Bethesda Naval Hospital at the time of the President's death. On the Monday or Tuesday following President Kennedy's autopsy, fellow Navy colleague Dennis David would enter Pitzer's office and see him working on a movie film that had been taken of the President's autopsy. Pitzer was making stills from the movie frames, and analyzing the movie as well. This film has never surfaced. It was believed to be the filming of the pre-examination which likely took place that night before the official autopsy got underway. Listen to our earlier Mysteries of the Enduring Secret episode that covers the two morgues at Bethesda to understand better how Pitzer's involvement fits into the mystery of the two morgues.  Along with Robert Knudsen, Pitzer may have been one of two main characters who were involved in producing the visual record of what was actually determined at the Presidents true pre-examination autopsy. Pitzer's death occurred just two days before he was due to retire from active military service. The FBI joined the investigation of his death, and J. Edgar Hoover was directly informed almost immediately about it, as well as the ongoing results of the investigation. While the death was ruled officially a suicide, the forensic evidence points to foul play. The fundamental question was whether Pitzer was in possession of any of those original autopsy materials taken at the pre-exam,  and whether there were men determined to gain possession of those materials, and possibly to silence Pitzer in the process. Dennis David observed those materials with Pitzer... and David stated that they clearly showed a shot from the front which had entered and then destroyed a major portion of President Kennedy's brain, creating the related blow out in  the rear of his head. Join Rick Russo  and I as we follow the trail and discuss the case with Pitzer's nephew Bruce Fernandez, who adored his uncle, and who believes was murdered…Pursuit of the truth in this case  has become a life long  endeavor for Mr. Fernandez.  So hurry up and get on over to our You Tube Channel JFK The Enduring Secret and watch this latest episode. I guarantee…you wont be disappointed! Oh, and if you haven't subscribed yet to our you tube channel…please do!  

Sermon by Tim Pitzer on 6-2-24 at New Covenant Church in Anderson, SC Psalm 1

In this episode, Dr. Seipp talks with Mr. Pitzer, Mr. Hellner, and a few students about the newly formed eSports team at Roxbury High School. This team has taken off and has tons of student interest. This program is just one more example of Roxbury working to design and implement opportunities that match students' interests.

Take and listen as I speak with Audio Engineer Jeff Pitzer from his home studio The FloodZone.

Sermon by Tim Pitzer on May 5, 2024 at New Covenant Church in Anderson, SC. Scripture Passage: Titus 2:11-14 Outline -What grace did -What grace does -What grace will do www.ncchurch.net

Joining the Native Angelino Podcast from Kyoto, Japan, Professor Linus Yamane speaks eloquently about the lessons the United States can learn from the Japanese economy. Heavy government debt levels restrain the ability of policymakers to correct problems even in light of obvious trends. An aging population, a declining population, increasing wealth disparity and education inequality pressure the social security system. What policy prescriptions are available to ensure the proper functioning and availability of the system for future generations? Bio: Professor Yamane is a Professor of Economics at Pitzer College in Claremont, California. He joined the Pitzer faculty in 1988, and is currently on sabbatical (2023-2024). His research interests include the Japanese Economy, Labor Economics, Econometrics and Macroeconomics. He attended Yale University (MA, MPhil, PhD)and the Massachusetts Institute of Technology (BS).About The Author And Podcast Host Tom LevineTom Levine is a Native Angelino and graduate of USC Marshall School of Business, the Claremont Colleges, and spent a term at the London School of Economics.Following a 25 year career in capital markets, Tom Levine founded Zero Hour Group in 2014. The Los Angeles, California-based firm provides consulting, strategic analysis, valuation and real estate services. Serving individuals, family offices, institutions and professional investors.Native Angelino Real Estate, established 2017, for residential, commercial and investment related transactions. Additionally, he is a consultant, broker and certified Short Sale and Forclosure specialist under the National Association of Realtors. (CADRE #2052698)The Native Angelino Podcast is underwritten and produced in conjunction with the Zero Hour Group.“From a vantage point within sight of the Hollywood Sign, seated beneath a palm tree, Tom Levine takes you on a twisted, exploratory tour of popular thought, the upside-down theories of classical economics, politics, and other strange things.Tom talks all things Los Angeles, bright new ideas, and complex topics of interest to creative thinkers and discerning skeptics.L.A. locals state with pride, "You can surf in the morning and ski in the afternoon." Well, if you get a really early start, it's true. Sometimes.Los Angeles is the City of the Angels, and Tom Levine is a Native Angelino. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.1929.live/subscribe

The Rev. John Pitzer is a native of Texas and currently lives in New Orleans, Louisiana, where he serves at Trinity Episcopal Church as associate rector of outreach/mission and pastoral care. For twenty years, Pitzer was a friar with the Order of Preachers, commonly known as the Dominicans. He served at St. Peter's Catholic Church in Memphis which has been a neighbor to Calvary for over a century. Pitzer believes that preaching the Good News of Jesus Christ--an all-inclusive Good News that is intended for everyone no matter our circumstances in life--is needed in this world like never before.

Topping interviews Shane Pitzer who is the Director of Channel Alliances for Wing Security. Learn about Shane's fascinating journey from joining the U.S Navy to providing IT solutions to fortune 500 companies to now leading Wing Security which focuses on securing SaaS applications in today's AI landscape. Topping Talks is Sponsored by Topping Technologies & ExpressVPN. Protect your online privacy https://www.xvuslink.com/?a_fid=toppi... also if your business needs IT assistance you can reach Topping Technologies at sales@toppingtechnologies.com FollowTopping on Twiitter-https://twitter.com/NicTopping

In 2004, April Beth Pitzer was in a terrifying situation. Nearly a decade after working as an undercover informant for the police, her past is catching up with her. She's just met a woman whose husband is in prison due to April's testimony against him. She knows she needs to get out of the area fast and makes plans to move in with her mom across the country. In a few days, April's bags were packed, and she said her goodbyes. But April never makes it home.   April Beth Pitzer was 30 years old when she went missing near Newberry Springs, California. She is white, 5'9”, with brown hair and hazel eyes. At the time of her disappearance, she weighed approximately 130lbs. She has a scar on her elbow, lip, left side of her stomach, and left side of her chest. She may have been wearing gold hoop earrings when she went missing.   Anyone with information is asked to call The San Bernardino County Sheriff's Department at 909-387-3690. Thank you to our sponsor, Factor. Go to FACTORMEALS.com/justice50 and use code justice50 to get 50% off. For more information about the podcast and the cases discussed, visit VoicesforJusticePodcast.com Don't forget to follow me on social media under Voices for Justice Podcast & SarahETurney The introduction music used in Voices for Justice is Thread of Clouds by Blue Dot Sessions. Outro music is Melancholic Ending by Soft and Furious. The track used for ad transitions is Pinky by Blue Dot Sessions. Learn more about your ad choices. Visit podcastchoices.com/adchoices

In this episode, we visit with one of the best women's teams this fall in the Pamona-Pitzer Women's golf team.  We get the chance to visit with Coach John Wurzer and two of his team leaders after an outstanding and well traveled fall schedule.  Emily Chang and Katelyn Vo have been two of the outstanding players so far this year and have been leading the Sagehens this fall.  We hope you enjoy the episode and Happy Holidays from D3 Golf Guys!!!Support the show

Sermon by Rev. Tim Pitzer on December 17th, 2023 at New Covenant Church in Anderson, SC. Passage: Isaiah 9:1-7 To Fix What Is Broken 1. A darkness to blame 2. A Son to behold 3. A Future to Claim

The Guild Mortgage Company wants to be your home loan lender. They do all types of mortgages; FHA, VA, USDA & Conventional. Guild Mortgage Company is an Equal Housing Lender; NMLS 3274. Roy West NMLS 316801 Phone (409) 866-1901.

In this episode, I speak with Percy Pitzer.  Percy has had a long career in corrections starting with the Bureau of Prisons, he rose through the ranks, eventually retiring as Warden.  After returning to work in private corrections, he started his own corrections audit company, Creative Corrections.  Percy and his family have also started the Pitzer Family Education Foundation.  The foundation has provided more than 190 scholarships to the children of incarcerated parents.You can reach Percy by phone 409-861-2536The Pitzer Family Education Foundation https://pfefscholarships.org/Creative Corrections https://creativecorrections.com/ PepperBall From crowd control to cell extractions, the PepperBall system is the safe, non-lethal option.OMNI OMNI is cutting-edge software designed to track inmates and assets within your prison or jail. Disclaimer: This post contains affiliate links. If you make a purchase, I may receive a commission at no extra cost to you.Support the showContact us: mike@theprisonofficer.comFacebook: https://www.facebook.com/ThePrisonOfficerTake care of each other and Be Safe behind those walls and fences!

Listen to JD's interviews with the Pittsburgh team that he got while on his road trip last week. (0:00) Nino Bonaccorsi (12:15) Cole Matthews (27:11) Dayton Pitzer (34:29) Mac Stout (42:42) Anthony Santaniello (50:27) Finn Solomon Learn more about your ad choices. Visit megaphone.fm/adchoices

We're joined by stellar K-8 Administrator and education enthusiast, Stefanie Pitzer for a special Back to School Edition of Peace, Love and Baseball. Stefanie gives an administrator's insight along with advice to educators looking to stay inspired and better their workplace for themselves and their students. We cover it all from technology in schools, to seeking out the right extracurriculars, and the power of being a reader for life. Wouldn't you know it? It all applies far past our years in the classroom! Plus... did we get a life long Cubs fan to admit Busch Stadium is better?! Listen up! Today's episode is brought to you by @Validity

JOIN US! IT'S FREE!   (AUGUST 19 – 10:00 A.M.)    “I approached a dense wood on the west side of the road, and on entering it formed my regiment” As the Third Corps moved out towards the Emmitsburg Road on the afternoon of July 2, 1863, it was just the continuation of falling dominoes that had begun earlier in the day when Union troops discovered Confederates in Pitzer's Woods. Join us as we discuss the events leading up to the more well-known move by the Third Corps.   MEET AT CAMPSITE AREA PITZER'S WOODS

Captivity at the hands of the Vietcong continues to bring hardships to Captain Rocky Versace, Lieutenant Nick Rowe, and Sergeant Dan Pitzer. Versace has been separated from the group, though two new prisoners, Army Master Sergeant Ed Johnson and Army Sergeant Len Tadios join Rowe and Pitzer.After attacking a guard and a second round of failed reeducation attempts, Rowe is labeled a hard case - similar to Versace's classification last week - and is told he will be shipped off a new camp, one less lenient than the already strict camps he has been in up to this point.The introduction and transition music heard on the podcast is composed and recorded by the eldest Ghosts of Arlington, Jr. While the rest of his catalogue is quite different from what he's performed for me, you can find his music on bandcamp.com under the names Caladrius and Bloodfeather.As always, a very special thanks to Mountain Up Cap Company for its continued help to spread the word about the podcast on Facebook at: https://www.facebook.com/MountainUpCapCompany Climb to Glory!For more information about the podcast visit: ·       The GoA website: https://www.ghostsofarlingtonpodcast.com    ·       Facebook: https://www.facebook.com/ghostsofarlingtonpodcast·       Twitter: https://twitter.com/ArlingtonGhosts·       Instagram: https://www.instagram.com/ghostsofarlington/ 

The Guild Mortgage Company wants to be your home loan lender. They do all types of mortgages; FHA, VA, USDA & Conventional. Guild Mortgage Company is an Equal Housing Lender; NMLS 3274. Roy West NMLS 316801 Phone (409) 866-1901.

CovCath (9-3 record in 2022) returns plenty of talent this season as it moves to Class 4A. The Colonels were in Class 5A last season. "The biggest thing right now is our guys are showing up to work," CovCath coach Eddie Eviston said. "We have a little different outlook on the year because of the different scenery with the different class, different district. It's one of those things you can't worry about that. We work every day and those guys have handled it real well." Senior quarterback Evan Pitzer and senior tight end Willie Rodriguez joined the podcast and discussed how close the team has been all year. "I'd say we're like all family," Pitzer said. "We'll hang out together. And I think that helps us on the field with the chemistry. We know what each other is going to do. But, not only that but I think we're hungry. We lost to Frederick Douglass last year in the second round. Our goal is a state championship every year, year in and year out. And I think a lot of guys want that and we're going to work it this year." Eviston said Pitzer and Rodriguez are among the leaders of an experienced group this year for the Colonels who open the season against visiting Ryle Aug. 18. "They've been a vital part of our program for the last two years," Eviston said. "As they enter their senior year we look to them for leadership. These guys continue to step up."See omnystudio.com/listener for privacy information.

Blue Rain Gallery welcomes Belle Brooke to the stable of featured artists. Belle Brooke Barer established Belle Brooke Designs in 2006 upon her return to Los Angeles. Born and raised in Houston, Texas, Barer ventured westward in 1997 to attend Pitzer College in Claremont, California. Her studies at Pitzer concentrated in various mediums of studio art, focusing mainly on photography. After moving north to the San Francisco Bay area, she began her jewelry studies at The Crucible in Berkeley, California, and later attended the Revere Academy of Jewelry Arts in San Francisco, where she received her professional certification as a goldsmith. After completing her studies, she worked for Studio 311 as a bench jeweler. Belle has been the recipient of various awards most notably the AGTA Spectrum awards in 2012 and 2018, the Mort Abelson New Designer of the Year award in 2008, and the Halstead Grant in 2007. She currently makes her home in Santa Fe, New Mexico where she runs her flagship store Rock + Feather in the new Siler Industrial area. All her jewelry is made in her workshop adjacent to the gallery, where she also teaches workshops and classes. View available jewelry at Blue Rain Gallery: https://blueraingallery.com/artists/belle-brooke/view-all

Often answers from the universe come after we have asked ourselves specific questions. The answers may come quickly, or may take some time. In this episode I talk again with one of my favorite people, Ashley Pitzer about how she uses this process in her life and in her creative process as a writer. In fact, she has used the techniques she shares to now channel two different novels. Understanding the creative process is helpful for everyone, since we are all creators in one way or another, so listen to this entire episode as it takes twists and turns live every Jamming with Jason episode. Be sure to subscribe and follow Ashley's Practicing Life Podcast at https://podcasts.apple.com/us/podcast/practicing-life-podcast-with-ashley-pitzer/id1626332113 Follow Ashley Pitzer at: https://ashleypitzer.com And get a copy of her debut novel, "The Birth Challenge: When Your Light Shines, Anyone Can Find You (Life Force Saga)" through you favorite book seller like Amazon: https://www.amazon.com/Birth-Challenge-light-shines-anyone/dp/1960260006/ It is an Epic Fantasy with a Chosen One and Slow Burn Trope. The story contains Magic & Superpowers. Female Main Character, but multiple character points of view. It's unlike any other fantasy book you've read and will help you know yourself better and understand love better. --- Support this podcast: https://podcasters.spotify.com/pod/show/jammingwithjason/support

Jim Brinkman, the manager of the Pitzer Ranch in Ericson, Nebraska, has been with the legendary ranch his entire life, and he's played an instrumental role in the ranch's success in the team roping world. He's a seasoned horseman and roper himself and has been involved in every aspect of the ranch's operation, from breeding and raising horses to training and competing on them.In this episode, Brinkman shares his insights on the Pitzer Ranch's history, its breeding program and its focus on producing top-quality performance horses for the team roping and ranch rodeo markets. He also talks about his personal journey in the team roping world and his experiences working with some of the top ropers and trainers in the industry—and how stallion incentives like the Riata Buckle and Royal Crown are reshaping the rope horse game on the heels of the American Rope Horse Futurity Association's explosive growth. In addition to his role at the Pitzer Ranch, Jim is also promoting the upcoming Pitzer Ranch Spring Sale, which is set to take place on April 22. He gives us a sneak peek into what buyers can expect at the sale and highlights some of the standout horses that will be offered.Whether you're a team roper, a rancher or just a horse lover, this episode is sure to provide valuable insights and inspiration. So tune in to The Team Roping Journal's The Score Podcast and join us for a conversation with Jim Brinkman of the Pitzer Ranch.---This episode is presented by 5 Star Equine Products. 5 Star's exclusive wool, quality and craftsmanship has set the standard in the equine industry. 5 Star's durability has been proven in the arena, on the ranch, and on the trail. Custom designs and styles to fit even the toughest of backlines, 5Star has a pad for your horse. And, best of all, all 5 Star Equine products are handcrafted in the USA! Let us take the worry out of keeping your horse comfortable, while you enjoy the ride. Customize your pad at 5StarEquine.com

im Brinkman, the manager of the Pitzer Ranch in Ericson, Nebraska, has been with the legendary ranch his entire life, and he's played an instrumental role in the ranch's success in the team roping world. He's a seasoned horseman and roper himself and has been involved in every aspect of the ranch's operation, from breeding and raising horses to training and competing on them.In this episode, Brinkman shares his insights on the Pitzer Ranch's history, its breeding program and its focus on producing top-quality performance horses for the team roping and ranch rodeo markets. He also talks about his personal journey in the team roping world and his experiences working with some of the top ropers and trainers in the industry—and how stallion incentives like the Riata Buckle and Royal Crown are reshaping the rope horse game on the heels of the American Rope Horse Futurity Association's explosive growth. In addition to his role at the Pitzer Ranch, Jim is also promoting the upcoming Pitzer Ranch Spring Sale, which is set to take place on April 22. He gives us a sneak peek into what buyers can expect at the sale and highlights some of the standout horses that will be offered.Whether you're a team roper, a rancher or just a horse lover, this episode is sure to provide valuable insights and inspiration. So tune in to The Team Roping Journal's The Score Podcast and join us for a conversation with Jim Brinkman of the Pitzer Ranch.---This episode is presented by 5 Star Equine Products. 5 Star's exclusive wool, quality and craftsmanship has set the standard in the equine industry. 5 Star's durability has been proven in the arena, on the ranch, and on the trail. Custom designs and styles to fit even the toughest of backlines, 5Star has a pad for your horse. And, best of all, all 5 Star Equine products are handcrafted in the USA! Let us take the worry out of keeping your horse comfortable, while you enjoy the ride. Customize your pad at 5StarEquine.com

Be sure to follow and connect with Stefanie on Twitter - @StefaniePitzer Book Adam for your next event! mradamwelcome.com/speaking Adam's Books: Kids Deserve It - amzn.to/3JzaoZv Run Like a Pirate - amzn.to/3KH9fjT Teachers Deserve It - amzn.to/3jzATDg Empower Our Girls - amzn.to/3JyR4vm Social Media: @mradawelcome

International Man of Mystery Jason Mefford talks about the greatest gift is hope. He is a man who serves in many capacities, including Risk Manager, Confidential Advisor, Teacher, Coach, and Podcaster. At heart, Jason is an Edu-Trainer, and his knowledge is vast. Please check out his two podcasts, Fire and Earth, and Jamming with Jason. This is another tables are turned #podcast episode where you get to hear Jason interviewed by Ashley. Be sure to subscribe and follow Ashley's Practicing Life Podcast at https://podcasts.apple.com/us/podcast/practicing-life-podcast-with-ashley-pitzer/id1626332113 Follow Ashley Pitzer at: https://linktr.ee/ashleypitzer And her debut novel, The Birth Challenge, waitlist is open. It is an Epic Fantasy with a Chosen One and Slow Burn Trope. The story contains Magic & Superpowers. Female Main Character. It releases on May 2nd! Chapter 1 of The Birth Challenge is available for free at https://BookHip.com/LFGTMZP FOR FULL SHOW NOTES AND LINKS VISIT: https://www.jasonmefford.com/jammingwithjason312/ SUPPORT THE PODCAST: https://anchor.fm/jammingwithjason/support DO YOU LOVE MUSIC LIKE ME? If so, learn how you can use it to intentionally heal and change your emotions as well as use it for entertainment at: https://bit.ly/MeffordMusic LIKED THE PODCAST? If you're the kind of person who likes to help others, then share this with your friends and family. If you found value, the will too. Please leave a review [https://itunes.apple.com/us/podcast/jamming-with-jason-mefford/id1456660699] on Apple Podcasts so we can reach more people. Join my Facebook group: https://www.facebook.com/groups/beinguniquely OTHER RESOURCES YOU MAY ENJOY: My YouTube channel [https://www.youtube.com/c/jasonleemefford] and make sure to subscribe My Facebook page [https://www.facebook.com/jammingwithjasonmefford] My LinkedIn page [https://www.linkedin.com/in/jasonmefford/] My website [https://jasonmefford.com] STAY UP TO DATE WITH NEW CONTENT: It can be difficult to find information on social media and the internet, but you get treated like a VIP and have one convenient list of new content delivered to you inbox each week when you subscribe to Jason's VIP Lounge at: https://jasonmefford.com/vip/ plus that way you can communicate with me through email and I don't have to censor myself like I do on social media, you get it straight from the horses mouth. --- Support this podcast: https://podcasters.spotify.com/pod/show/jammingwithjason/support

Sermon Recording by Tip Pitzer on 02-19-23 at New Covenant Church in Anderson, SC Scripture Passage: Mark 4:35-41 www.ncchurch.net

Do you want to write a book? Since she was a little girl, Ashley wanted to write a book but kept putting it off as life got in the way. Hear her story and see how when she surrendered and got into the flow, the universe helped the words flow and her new book "The Birth Challenge" will be out soon... and it's not a maternity book, but a fantasy / science fiction novel. When you listen to this #jammingwithjason #podcast episode you will learn how easy something even as hard as writing a book can be, and how the synchronicities of life start unfolding when you get into alignment. In fact, there are plenty of synchronicities Ashley and I uncovered in how our own lives of dreaming of being a writer unfolded. FOR FULL SHOW NOTES AND LINKS VISIT: https://www.jasonmefford.com/jammingwithjason310/ Connect with Ashley and get on the waitlist and download the first chapter of her new book at: https://linktr.ee/ashleypitzer SUPPORT THE PODCAST: https://anchor.fm/jammingwithjason/support DO YOU LOVE MUSIC LIKE ME? If so, learn how you can use it to intentionally heal and change your emotions as well as use it for entertainment at: https://bit.ly/MeffordMusic LIKED THE PODCAST? If you're the kind of person who likes to help others, then share this with your friends and family. If you found value, the will too. Please leave a review [https://itunes.apple.com/us/podcast/jamming-with-jason-mefford/id1456660699] on Apple Podcasts so we can reach more people. Join my Facebook group: https://www.facebook.com/groups/beinguniquely OTHER RESOURCES YOU MAY ENJOY: My YouTube channel [https://www.youtube.com/c/jasonleemefford] and make sure to subscribe My Facebook page [https://www.facebook.com/jammingwithjasonmefford] My LinkedIn page [https://www.linkedin.com/in/jasonmefford/] My website [https://jasonmefford.com] STAY UP TO DATE WITH NEW CONTENT: It can be difficult to find information on social media and the internet, but you get treated like a VIP and have one convenient list of new content delivered to you inbox each week when you subscribe to Jason's VIP Lounge at: https://jasonmefford.com/vip/ plus that way you can communicate with me through email. --- Support this podcast: https://podcasters.spotify.com/pod/show/jammingwithjason/support

Show Notes - Ashley is an independent multi talented author You can find more about here here https://linktr.ee/ashleypitzer If you are ready to shift your limiting beliefs this year, then join me for the free masterclass training on Feb 21st  "Activating Your Unique Abundance Codes"Send me an email support@padmaali.com and I will add you to the list.Subscribe to my YouTube Channel to get more content specifically on spiritual growth*********If you are ready to discover and monetize your Life's Purpose / your Dharma, watch this FREE training 'Monetize Your Purpose'.Padma Ali is a coach and a guide helping evolved purpose-driven, executives like you to create impact by aligning with your highest potential For more information visit www.padmaali.com.****Special Announcement****I have  TWO spots for one-on-one coaching for Feb 2023, please Email padma@padmaali.com to request a call or schedule a one-time session here. Serious interest only.***************If you've enjoyed this episode and felt inspired, we'd love to hear about it and know your takeaway. Take a screenshot of you listening on your device, post it to your insta stories and tag me @padmaali.OTHER RESOURCES FOR YOUPlease leave a review on iTunes or Spotify! InstagramLinked InYouTube ChannelFacebook

Dawnee Pitzer, owner of Events by Dawnee, is an event planner who believes that creativity is critical to happiness and success.Realizing she had a passion for event planning back in 2007, Dawnee sought out a career in the event planning industry, allowing her to be creative, yet structured. With an eye for detail and design, Dawnee has drawn upon her organizational skills to help clients design, plan, organize and carry out event details, manage and communicate with vendors, and ensure that every event runs smoothly. Discovering that creativity was what relaxed her mind and destressed her soul, Dawnee has branched out to corporate and nonprofit events and events in the entertainment industry.  Her goal is to make each event an experience, where guests engage in an all encompassing experience, not simply an event.  Based in the San Gabriel Valley, Dawnee not only offers services in California, but destination events from Hawaii to New York and beyond. Dawnee has the ability to envision events from start to finish, execute every detail and come up with ideas that clients may not have imagined.  With a staff of 10 incredible event planners, florists, servers and bartenders, let Dawnee and her team create something wonderful for you.Website: eventsbydawnee.comInstagram: @eventsbydawneeEmail: dawnee@eventsbydawnee_____________ Music Podcast Intro and OutroEveryday, Jason Farnhmam, YouTube Audio Library Podcast AdvertisementI love you, Vibe Tracks, YouTube Audio Library Sour Tennessee Red (Sting), John Dewey and the 41 Players, YouTube Audio Library Dewey, Cheedham, and Howe (Sting), John Dewey and the 41 Players, YouTube Audio Library Film Project Countdown.flac Copyright 2013 Iwan Gabovitch, CC-BY3 license

Sermon by Tim Pitzer on December 4, 2022 at New Covenant Church in Anderson, SC. Luke 2:1-7, Hebrews 1:1-4 www.ncchurch.net

What's a NESCAC anyway? Bates College admissions officer Scott Alexander joins the show to share a current view of his college and other NESCAC schools. Pitzer College admissions officer also joins the show to discuss the Pitzer essay supplements. And in our latest Personal Finance segment, we'll go over the benefits of establishing an emergency fund.

What's a NESCAC anyway? Bates College admissions officer Scott Alexander joins the show to share a current view of his college and other NESCAC schools. Pitzer College admissions officer also joins the show to discuss the Pitzer essay supplements. And in our latest Personal Finance segment, we'll go over the benefits of establishing an emergency fund.

Fifth ward Columbia city councilman Matt Pitzer announced this week that he will not seek re-election in April. Councilman Pitzer outlined his decision on 939 the Eagle's "Wake Up Mid-Missouri," telling listeners he's delivered on his promises regarding public safety and infrastructure. He also explained the long hours it takes to serve on the council and the impact that has on families:

Procurated's founder and CEO, David Yarkin, sat down with Jack Pitzer, a public procurement legend whose career began in 1966 and spanned more than 40 years, to discuss the evolution of procurement during his tenure, and what it means for the future. Jack worked in two state procurement offices (and was the CPO of IA) and ran procurement for a university and a large local government. He was a leader in National Association of State Procurement Officials (NASPO), becoming its president in 1984. To understand the future of procurement we must understand the history that has brought us to the point where we are today. Jack provides context and insight into the decisions that have led to our recent transition to a more digital world and an emphasis on technology, collaboration, and communication.

Caroline talks to Eric Pitzer, a communication coach and organization builder. In the last 10 years, he's appeared on BBC news on the way to Everest Basecamp, a fashion runway in Mexico City, and on Chilean national television. He helps leaders and organizations achieve goals through communication and leadership, with a focus on what makes us human. Eric is a native Ohioan and currently resides in Santiago, Chile. We Cover: Eric's journey to becoming a communication coach Overcoming his fear of public speaking What a communication coach is How anyone can become a great communicator Tangible tips for learning effective communication    Resources: Eric Pitzer: LinkedIn - linkedin.com/in/ericdpitzer Eric Pitzer: Website - ericpitzer.com Music by Real Topeka People TikTok: @realtopekapeople #connect #piece #event #Spanish linguistics #others #story #curious #fun #whether #yourself #challenge #working #able #process

Sermon by Rev. Tim Pitzer on September 11, 2022 at New Covenant Church in Anderson, SC. Scripture Passage: James 1:1-5 Outline: What you should do Why you should do it How to do it www.ncchurch.net

Sermon by Tim Pitzer on 9/4/22 at New Covenant Church in Anderson, SC. Scripture Passage: Acts 26:12-18 Outline: 1. What were you saved from? 2. What were you saved to? 3. Why it matters.

Welcome to the last week of our Pride Summer Special!! This week on the show, we welcomed MFQC newcomer Kareesa Kron (they/them) as our guest host! Kareesa chatted with Nancy Williams (she/her), a Chemistry Professor at the Keck Science Department at Claremont McKenna, Scripps, and Pitzer Colleges. They discussed Nancy's path through academia and her process of coming out as a trans woman after becoming a tenured faculty member at the Claremont Colleges. She explores her increasing involvement in DEI committees as the Claremont Colleges evolve to be more diverse and accepting to queer students. She also discusses her active involvement in deep canvassing through the LA LGBT Center and the Trans Chorus of LA and how she has built community in these spaces. This episode is benefitting the LA LGBT Center (chosen by our guest host, Kareesa) and the GoFundMe fundraiser is LIVE (https://gofund.me/726c9923) and will close 9/10. To connect with Nancy you can follow her on Twitter @NancySBWilliams (and us @MFQCPod). We'll see y'all next time and remember that Black Lives Matter today and everyday. --- Support this podcast: https://anchor.fm/mfqc/support

Join the team as they discuss the disappearance of April Pitzer.  The 30 year-old mother of two went missing from Newberry Springs, California in 2004.  Was her disappearance linked to organized crime?If you have any information on April's disappearance, contact the San Bernardino Sheriff's department760-256-4838909-387-3690You can reach us on Instagram: smalltownmissing Sources for this episode –https://charleyproject.org/case/april-beth-pitzerhttps://ncmissingpersons.org/april-pitzer/https://www.4029tv.com/article/clarksville-april-pitzer-missing/28234648https://www.durangoherald.com/articles/intrigue-surrounds-silverton-area-plane-crash/https://disappearedblog.com/april-pitzer/http://www.undergroundexplorers.com/inland_empire_april_pitzer.pdfhttps://missingsouls.com/april-pitzer/https://www.thv11.com/article/news/local/family-still-struggles-10-years-after-disappearance-of-daughter/91-287109683#:~:text=Pitzer's%20daughters%20Kennedy%20and%20Bradley,case%20they've%20ever%20had.https://www.vvdailypress.com/story/news/crime/2016/10/12/authorities-ask-for-public-s/25215110007/

This month on Episode 39 of Discover CircRes, host Cynthia St. Hilaire highlights four original research articles featured in the August 5th and 19th issues of the journal. This episode also features an interview with Dr Annet Kirabo and Dr Ashley Pitzer from Vanderbilt University on their article, Dendritic Cell ENaC-Dependent Inflammasome Activation Contributes to Salt-Sensitive Hypertension.   Article highlights:   Jain, et al. Role of UPR in Platelets   Orlich et al: SRF Function in Mural Cells of the CNS   Xue et al: Gut Microbial IPA Inhibits Atherosclerosis   Wang et al: Endothelial ETS1 on Heart Development   Cindy St. Hilaire:        Hi, welcome to Discover CircRes, the podcast of the American Heart Association's journal Circulation Research. I'm your host, Dr Cindy St. Hilaire from the Vascular Medicine Institute at the University of Pittsburgh, and today I'm going to be highlighting articles from our August 5th and August 19th issues of Circulation Research. I'm also going to have a chat with Dr Annet Kirabo and Dr Ashley Pitzer from Vanderbilt University about their study, Dendritic Cell ENaC-Dependent Inflammasome Activation Contributes to Salt-Sensitive Hypertension.   But before I get to the interview, I first want to share an article from our August 5th issue, and that article is titled, Unfolded Protein Response Differentially Modulates the Platelet Phenotype. The first author of this study is Kanika Jain and the corresponding author is John Hwa from Yale University. Self-stress can lead to protein misfolding, and the accumulation of misfolded proteins can lead to a reduction in protein translation and may alter gene transcription, a process collectively known as the unfolded protein response, or UPR. UPR is well documented in nucleated cells; however, it has not been studied in platelets, which are anuclear, but do have a rapid response to cellular stress. In this study, they investigated the UPR in anucleate platelets and explore its role, if any, in platelet physiology and function.   They found that treating human and mouse platelets with various stressors caused aggregations of misfolded proteins and induction of UPR-specific factors. Oxidative stress, for example, induced the UPR kinase PERK, while an endoplasmic reticulum stressor induced the transcription of the UPR factor XBP1. The team went on to study the UPR in platelets from people with type II diabetes, which is a population in which platelet mediated thrombosis is a major complication. They showed that protein aggregation and upregulation of the XBP1 pathway in diabetic patient platelets correlated with disease severity. Furthermore, treating the diabetic patient platelets with a chemical chaperone that helps to correct protein misfolding reduced protein aggregations and prevented the cells prothrombotic activation. This work confirms that even without transcription, platelets display stress-induced UPR, and that targeting this response may be a way to reduce thrombotic risk in diabetic patients.   Cindy St. Hilaire:        The second article I want to share with you is from our August 5th issue and is titled, Mural Cell SRF Controls Pericyte Migration, Vessel Patterning and Blood Flow, and it was led by Michael Orlich from Uppsala University in Sweden. Blood vessels are lined with endothelial cells and surrounded by mural cells. Vascular smooth muscle cells are the mural cells in the case of veins and arteries, and pericytes are the mural cells in the case of capillaries. In the capillaries, pericytes maintain blood-brain and blood-retina barrier function and can mediate vascular tone, similar to smooth muscle cells. While these pericytes and smooth muscle cells are related, they have distinct roles and characteristics.   To learn more about the similarities and the differences between pericytes and smooth muscle cells, this group examined how each would be affected by the absence of SRF in the other. SRF is a transcription factor, essential for nonvascular or visceral smooth muscle cell function. In visceral smooth muscle cells, SRF drives expression of smooth muscle actin and other smooth muscle genes. Using mice engineered to lack SRF in mural cells, they show that SRF drives smooth muscle gene expression in these pericytes and smooth muscle cells, and its loss from smooth muscle cells causes atrial venous malformations and diminishes vascular tone. In pericytes, loss of SRF impaired cell migration in angiogenic sprouting. In a mouse model of retinopathy, activation of SRF drove pathological growth of pericytes. This work not only highlights the various functions of SRF in mural cell biology, but it also suggests that it has a role in pathological capillary patterning.   Cindy St. Hilaire:        The third article I want to share is from our August 19th issue of Circulation Research and is titled, Gut Microbially Produced Indole-3-Propionic Acid Inhibits Atherosclerosis by Promoting Reverse Cholesterol Transport and its Deficiency Is Causally Related to Atherosclerotic Cardiovascular Disease. The first authors are Hongliang Xue and Xu Chen, and the corresponding author is Wenhua Ling from Sun Yat-Sen University in Guangzhou, China. Recent studies provide evidence that disorders in the gut microbiota and gut microbiome derived metabolites affect the development of atherosclerosis. However, which and how specific gut microbial metabolites contribute to the progression of atherosclerosis and the clinical relevance of these alterations remain unclear. Gut microbiome derived metabolites, such as short-chain fatty acids and trimethylamine N-oxide, or TMAO, have been found to correlate with atherosclerotic disease severity.   This study has now found that serum levels of indole-3-propionic acid, or IPA, are lower in atherosclerosis patients than controls. The team performed unbiased metagenomic and metabolomic analyses on fecal and serum samples from 30 coronary artery disease patients and found that, compared with controls, patients with atherosclerosis had lower gut bacterial diversity, depletion of species that commonly produce IPA and lower levels of IPA in their blood. Examination of a second larger cohort of atherosclerosis patients confirmed this IPA disease correlation. The team also showed serum IPA was reduced in a mouse model of atherosclerosis, and that supplementing such mice with dietary IPA could slow disease progression. Analysis of the macrophages from these mice showed that IPA increased cholesterol efflux, and the team went on to elucidate the molecular steps involved. The results of this study not only unraveled the details of IPA's influence on atherosclerosis, but suggest boosting levels of this metabolite could slow atherosclerotic disease progression.   Cindy St. Hilaire:        The last article I want to share is also from our August 19th issue, and it's titled, Endothelial Loss of ETS1 Impairs Coronary Vascular Development and Leads to Ventricular Non-Compaction. The first author is Lu Wang and the corresponding author is Paul Grossfeld, and they are at UCSD. Congenital heart defects, or CHDs, are present in nearly 1% of the human population. In some cases, the heart defects result from a genetic error, which can give researchers clues to its etiology. Jacobson syndrome is a complex condition caused by deletions from one end of chromosome 11, and the occurrence of a congenital heart defect in this syndrome has been associated with the loss of the gene ETS1. ETS1 is an angiogenesis promoting transcription factor, but how ETS1 functions in heart development was not known.   Wang and colleagues now show that both global or endothelial-specific loss of ETS1 in mice caused differences in embryonic heart development that ultimately led to a muscular wall defect known as ventricular non-compaction. The mice also had defective coronary vasculogenesis associated with decreased abundance of endothelial cells in the ventricular myocardium. RNA sequencing of ventricular tissue revealed that, compared with controls, mice lacking ETS1 had reduced expression of several important angiogenesis genes and upregulation of extracellular matrix factors, which together contributed to the muscular and vascular defects.   Cindy St. Hilaire:        Today I have with me, Dr Annet Kirabo and Dr Ashley Pitzer, both from Vanderbilt University, and we're going to talk about their paper, Dendritic Cell ENaC-Dependent Inflammasome Activation Contributes to Salt-Sensitive Hypertension. This article is in our August 5th issue of Circulation Research. Thank you both so much for joining me today.   Annet Kirabo:             Yeah, thank you so much for having us.   Ashley Pitzer:              Yeah, thank you for having us.   Cindy St. Hilaire:        Yeah, it's a great paper. I think we're all familiar with hypertension and this idea that too much salt is bad for our cardiovascular system. When I was a kid, my grandparents had those salt replacements on their kitchen table, Mrs. Dash and whatever. But, like you said in the start of your paper, the exact mechanism by which salt intake increases blood pressure and also increases cardiovascular risk, it's not really well understood, and you guys are focusing on the contribution of immune responses in this process or in this pathogenesis. Before we dig into the details of your paper, I was wondering if you could give us a little bit of background about what's known regarding the role of inflammation in this salt-sensitive hypertension pathogenesis.   Annet Kirabo:             Yeah. It's difficult to know where begin to from, but the role of inflammation in cardiovascular disease have been known for many, many decades. Right now, Dr David Harrison showed more than 10 years ago that T cells contribute to hypertension, but the mechanisms were not known. Back when I was a post doc in David Harrison's lab, we discovered a new mechanism, how immune cells are activated in inflammation and hypertension, whereby we found that there is increased oxidative stress in antigen-presenting cells. This leads to formation of oxidative products known as arachidonic acid or lipid products known as isolevuglandin, or IsoLGs. These IsoLGs are highly, highly reactive and they adapt to lysines on proteins. This is a covalent binding, which leads to permanent alteration of proteins, and so these proteins act as neoantigens that are presented as self-antigens to T cells, leading to an autoimmune-like state in hypertension.   Annet Kirabo:             We found that these antigen-presenting cells are activated and they start producing a lot of cytokines that paralyze T cells to IL-17 producing T cells that contribute to hypertension. And so, when I started my lab back in 2016, we discovered that excess dietary salt profoundly activates this pathway, and we found for the first time that these antigen-presenting cells, they express ENaC, the epithelial sodium channel, and sodium goes into these antigen-presenting cells and activates the NADPH oxidase, which is an enzyme which produces this reactive oxygen species, leading to this IsoLG formation, which I've talked about, and leading to inflammation.   So, three years ago when Ashley joined my lab, she had extensively studied the inflammasome in her PhD program, and she suggested why don't we look at the role of the inflammasome in this pathway and how IsoLG may contribute to this. In her paper that we are discussing right now, she found that in a dependent manner, sodium enters the cell and activates this pathway, and the NLRP3 inflammasome is involved in this process.   Cindy St. Hilaire:        That's such a wonderful story that fits together so many pieces. One of the things you talk about, which I guess I didn't even appreciate myself is, there are certain individuals out there who are more salt-sensitive than others.   Annet Kirabo:             Yeah.   Cindy St. Hilaire:        What is that difference? Do we know the root cause of that? And then also, how many individuals are we talking about are salt-sensitive?   Annet Kirabo:             Salt-sensitive blood pressure, it is a variable trait and it's normally distributed in the population, but it happens more in some individuals than others. It happens even in 25% of people without any hypertension. These people go to that doctor, that doctor thinks they're normal, they don't have any hypertension, but these people can be at a risk of sudden heart attack or cardiovascular risk or even a stroke, simply because when they eat a salty meal, their blood pressure will go up.   Cindy St. Hilaire:        Yeah, that's one of my questions. How much salt are we talking about here? And not only how much in a meal, but a sustained amount? How bad is a miso soup a day?   Annet Kirabo:             Yes. The American Heart Association and the World Health Organization have recommendations. American Heart Association recommends one spoon per day. We have refused to adapt to this recommendation, but that is the recommendation that they have recommended per day to eat. But this is difficult because most of the salt, as you know, is already in our food through processing in our processed foods and we don't have any control over how much salt we have, and there's also a lot of adding of salt at a table.   Cindy St. Hilaire:        Ashley, your background was more the inflammasome. What were your thoughts entering into this project? Did you have much of a hypertension background?   Ashley Pitzer:              No. My graduate thesis focused mainly on endothelial dysfunction and cardiovascular disease, and so it was a pretty easy segue. But it was just with Annet, so excited about the project and showing me all the data and this robust IL-1 beta production that she was seeing after these immune cells being exposed to high salt, I, with my inflammasome background, was immediately like, this could be playing a role. And so it was, like I said, a pretty easy transition and, as is in the paper, we're doing human studies. All of my research back in grad school was very basic research, so it was very exciting to see how our research was being translated with people having this condition and potentially finding mechanisms where we can target this to help actual people.   Cindy St. Hilaire:        I think a lot of us who are not in the hypertension field, and maybe this was you before you joined Annet's lab, we really only kind of think of the kidneys and the blood vessels when we think about hypertension, but studies like this are changing that. And I think a lot of Annet's earlier work, as well as the work of others, have shown a role for this epithelial sodium channel as an important player in this salt-induced hypertension. New to me, it's not just found in the kidney, which I totally did not appreciate that. And it's this channel sensing the salt that can trigger this IL-1 beta production that does a whole bunch of other things.   Cindy St. Hilaire:        What are those other things? What are those cells that are affected and where is this happening? Obviously it's not just kidney cells, but is it only in the kidney or are these systemic cells? What do we think is happening?   Ashley Pitzer:              That's the question, is, where is this happening? There's been studies at Vanderbilt by Jens Titze and his lab showing, where are these immune cells sensing the salt? And so they've shown that sodium accumulates in the skin, a huge argument is for they're sensing the sodium in the kidney because that's where a lot of it is being processed. But these immune cells travel through the whole body, so they're seeing it where there are the highest amounts of sodium concentration, and so I would argue it's in the kidney.   Annet Kirabo:             Indeed, because we're now collaborating with Tina Kon, and we have recently published with her a paper in the International Journal of Science, where we have done sodium MRI and we find this accumulation of sodium in the kidney even much more than in the skin. And we know that the kidney is where sodium is highly concentrated. So the working hypothesis in the lab is that these immune cells can be activated wherever they are, in the lymph nodes or not, in other tissues, but they can travel to the kidney.   We find that in high salt, if you feed high salt to the mouse, the endothelium in the kidney becomes dysfunctional and it expresses molecules, chemoattractants, that attract these immune cells in the kidney. We think that the high salt accumulation in the kidney can activate these, and then these immune cells are activated and they produce cytokines. Dr Steve Crowley showed that they can produce IL-1 beta, which induces activation of sodium channels that can be induced. We have also actually found that even IL-17 can be produced by these immune cells in the kidney and they can activate sodium channels in the kidney, leading retention of sodium and water and hypertension.   Cindy St. Hilaire:        Very cool. You used a lot of mice in this paper. Can you tell us, I just want to know a little bit about the models you chose to use, but also how similar is hypertension in mouse and humans? Obviously for atherosclerosis, we have to do lots of things to get them to form a plaque. Is hypertension similar in a mouse and do mice also show this salt-sensitive phenotype?   Annet Kirabo:             That is an extremely important point. If you read our paper, we use a slightly different approach. Most people do benchside to bed approach. We did the opposite. We did a bed to benchside approach.   Cindy St. Hilaire:        Always smart.   Annet Kirabo:             Yeah. We first started humans, and then with some references, we went to the mice, because I think when it comes to salt-sensitive blood pressure, mice are different from humans. In fact, if we look in the lab, we find that female mice are protected from salt-sensitive blood pressure, but we find that in the humans, it's the opposite. Females are more prone to salt-sensitive hypertension. Those are studies that we are doing right now. We haven't published. But we know that it can be different.   The model we use most of the time in the lab, the C57 mice, are resistant to salt-sensitive hypertension. These C57 mice would rather die before they raise their blood pressure in response to salt. We can induce salt-sensitivity in these mice like in the paper that we are discussing. When we induce the endothelial dysfunction using L-NAME and we wash it out, then these mice, when you give them, subsequently, salt, suggests that they become salt-sensitive. But we also have a salt-sensitive mouse model that we use, the 129/SV mouse. So we use several models to kind of prove the same thing over and over again with the findings that we found in humans.   Cindy St. Hilaire:        And you used a technique, which I'm a little bit familiar with, but I'd like to hear, A, about it from you, but also your experience in using it, and that is CITE-seq. So, how does that work?   Ashley Pitzer:              That was with our human study where we actually had patients come in, who were hypertensive, took them off medication for 2 weeks. They come in, we get baseline samples, we give them a salt load on one day, and then the next day we completely salt deplete them.   Cindy St. Hilaire:        How much is a salt load? Like a Big Mac? What's a salt load?   Ashley Pitzer:              Yeah, it's pretty much just like eating Lays chips all day. It's a lot of salt. It's a very salty meal.   Annet Kirabo:             And then in addition, we also infuse saline too.   Cindy St. Hilaire:        Oh, wow.   Annet Kirabo:             Because these people, when they come into the hospital, some them have already eating high salt. This approach is to just maximize the whole system so that then when we sort deplete everybody, it's at the same level and it's just to unify the whole process. But sorry, Ashley, you go ahead.   Ashley Pitzer:              With the CITE-seq, we're able to take different patients on different days. So we take samples each day, and we can give each sample a barcode, basically. Give them a barcode, we can pool them all together, process them, and we can sequence their RNA, we can probe for a certain amount of protein expression as well. So then when we analyze, we can look at protein expression, so you get the translation and the transcription for each person on each day, and then you're able to compare. And so you get this huge picture and it's a lot of data.   Cindy St. Hilaire:        How long did it take you to sort through?   Ashley Pitzer:              Well, we have a statistician who does all of that, because my wheelhouse is here and it is on a different planet. So we have somebody who helps us with that who does an unbiased approach. And then once he does an analysis, gives us back what are the things that are changing the most, and one of those was IL-1 beta.   Annet Kirabo:             As you can see, our list is huge, this is a massive input of so many collaborators. We have computational people on there that help us with this. I can't even begin to learn these techniques, but with all this collaboration and the resources at Vanderbilt, these things are possible. And so, this is a really powerful approach where you can combine protein expression and you get the specific cells that express the genes and you couple the channel type to the gene expression.   Annet Kirabo:             We actually found that not all monocytes are the same. There's a specific class that of monocytes, A small class of monocytes that is so angry, and the inflammasome is activated and producing this IL-1 beta, and that is enough to contribute to this phenotype of salt-sensitive hypertension, which dynamically changed according to blood pressure, suggesting that this is a targetable salt-sensitive blood pressure, even in normotensive people, is a targetable trait. And because these monocytes are in blood, can we get a blood sample and routinely diagnose salt-sensitive blood pressure so that doctors are aware and they can appropriately advise patients.   Cindy St. Hilaire:        This was samples obviously taken from a blood draw, right? So they're circulating.   Annet Kirabo:             It was a blood draw, yes.   Cindy St. Hilaire:        What do you think about these immune cells, perhaps, native in the kidney? Do you think the small population of angry cells, like you said, is escaping from the kidney environment? What do you think?   Annet Kirabo:             When I was a post-doc in David Harrison's lab, we found that the most angry dendritic cells that contribute to this inflammation and hypertension are monocyte-derived. So that's why in the human study we focused on monocytes, because there are so many subtypes of dendritic cells, plasmacytoid dendritic, classical dendritic cells. We have studied all of these subtypes, and we have focused on monocyte-derived dendritic cells because they're the ones that seem to be contributing to this phenotype the most.                                     Cindy St. Hilaire:        You guys focused in on the NLRP3 inflammasome, which, obviously it's a really critical component broadly for the innate immune system. Do you think that this is going to be a targetable approach that can be leveraged for hypertension? Or do you think it's too broad? What do you think about that as a therapeutic potential?   Ashley Pitzer:              Even when you look in our paper, and we use a knockout model, where we use a completely global knockout model, put them on high salt, and we give them back only dendritic cells that are from wild-type mice, so they have that NLRP3, that have been exposed to high salt. We were able to increase blood pressure, but I also did, in mice, where I gave them an IL-1 beta neutralizing antibody, similar to canakinumab, which is the CANTOS trial, and there's not much of a difference. There is, but it's minor. It's very minor.   Ashley Pitzer:              So, to be able to target in specific cell types in humans one thing, it's very difficult, and maybe one day we can get there. But I think it at least gives us a better idea of what is the full picture, what's the big mechanism going on with immune cells? In part of our human study, we are looking at something to try and be able to identify who is salt sensitive. So if anything, we're able to sit here and potentially have a way of identifying salt-sensitive patients, where, right now, all we can do is have them come in like we do and do a 3-day study, and not everybody can do that.   Annet Kirabo:             To add onto that, perhaps you know, we are talking about precision medicine. This is an era of precision medicine where you need to really tailor treatments if we can get there, and I think this is one way. CANTOS trial. They had no way of knowing who is salt-sensitive and who is not, it was a global approach, and the lack of differences in blood pressure might be explained that this IL-1 beta pathway is targetable in a specific population whose blood pressure is probably driven by inflammation. There are so many, many mechanisms that drive hypertension, and so perhaps we need to focus this on salt-sensitive people, and maybe we can really use this approach to target. Plus, this is ENaC-dependent.   As you know, amiloride has lost favor in the clinic as a treatment of hypertension, because in the majority, it's not effective. But studies have shown that in Black men, for example, who had been categorized salt-resistant, when they give them amiloride, their blood pressure went down, and yet it's not effective in the majority of the people.   So, can we bring back, can we take another look at amiloride. As our studies indicate that blockade of ENaC is anti-inflammatory and it's also antioxidant agent, can we at least bring back amiloride and look at it again and we focus it for specific populations of people that may be more prone to salt-sensitive hypertension?   Here we have so many targets for potential precision treatment of salt-sensitive potential in this paper. You can target SGK1, which we know is possible, we listed a number of clinical trials that they have used NLRP3 inflammasome inhibitors, you can use amiloride for these people, and you can also potentially scavenge IsoLGs.     Cindy St. Hilaire:        What was the most challenging aspect of this study? There's a lot of moving parts, so what was the biggest challenge? And then, also, what was the most surprising part or the most pleasantly surprising part?   Ashley Pitzer:              You have to think, most of this was going on right when the pandemic hit. And right before that, we had started our human recruitment for the human study. And so that put a little bit of a time damper on it.   Ashley Pitzer:              Other than that, it was just, we were finding one thing, developing a new experiment, doing it again, doing it again. And honestly, what was the most surprising and rewarding was just seeing the same thing in, because we took just PBMCs from normotensive patients, treated them with high salt, and saw the changes that we did with the inflammasome. And to see that exactly again in an in vivo model of giving patients high salt and seeing the same thing, it was very rewarding and confirmed that, okay, we're on the right path. Seeing the same thing over and over and over again, it kind of reaffirms that you had a good idea.   Annet Kirabo:             I might add, one of the most challenging was, initially, the computational. Oh, part of the pandemic I was, the pandemic hit, I had a baby during the pandemic, and it was my time to leave my home, and then all these things were going on. We had a clinical trial where patients had to come in. Vanderbilt was so super supportive ,even checking for COVID-19. Our patients could not have COVID-19. We needed to check them.   Cindy St. Hilaire:        Yeah.   Annet Kirabo:             They also had to check for COVID-19. And so during that time, I realized, wait, I need learn computation analysis. I realized I cannot learn, and then reached out to collaborators that helped. That was extremely challenging. And then the other challenging thing that we faced later during the pandemic is vaccinations. In our criteria, these people cannot be vaccinated for reasons. We've studied inflammation, hypertension, and so vaccination was confounding. And even COVID-19 is even more for confounding. So we had this exclusion criteria where we could not recruit anyone.   Annet Kirabo:             Everybody was having COVID, everybody was being vaccinated, and everybody was in that exclusion criteria, so it was difficult to get people. We have had some slow down, but right now it's beginning to build up.   Cindy St. Hilaire:        So, what's next? What's the next question?   Annet Kirabo:             We have so many.   Cindy St. Hilaire:        That means it was a great study. If you have more, that means it was a great study.   Annet Kirabo:             Yeah. This study and us, it kind of warms. The inside seat just opened up, we have primary data in the genetic regulation of ENaC, we have primary data where we found. We are trying to figure out the specific ENaC channel in these antigen-presenting cells. We don't know. We found that ENaC delta, for example, it's not found in a kidney or you talked about a kidney contribution versus immune cells. ENaC delta is not found in the kidney, but we have primary data that show that ENaC delta is the most correlated with cardiovascular risk, is the most correlated with kidney disease and all forms of hypertension. So now we're like, ENaC delta expressed in the immune cells, not in the kidney, it is the one that is most involved in cardiovascular disease, so how are we going to tell the world that.   Cindy St. Hilaire:        Yeah, very cool.   Annet Kirabo:             Those cells, not necessarily the kidney. The kidney plays a part because the cells are going there, but it's very, very exciting. Plus a number of other lines that we are investigating.   Cindy St. Hilaire:        It's great. Well, congratulations, again, on this publication, on just getting all this done with what sounds like extremely difficult patient recruitment. So, Dr Kirabo and Dr Pitzer, thank you so much for joining me today and I'm looking forward to these next studies on maybe ENaC delta.   Annet Kirabo:             Thank you. Thank you so much.   Ashley Pitzer:              Thank you for having us.   Cindy St. Hilaire:        That's it for the highlights from the August 5th and August 19th issues of Circulation Research. Thank you for listening. Please check out the CircRes Facebook page and follow us on Twitter and Instagram with the handle @CircRes and hashtag Discover CircRes. Thank you to our guests, Dr Annet Kirabo and Dr Ashley Pitzer.   This podcast is produced by Ashara Ratnayaka, edited by Melissa Stoner, and supported by the editorial team of Circulation Research. Some of the copy text for the highlighted articles is provided by Ruth Williams. I'm your host, Dr Cindy St. Hilaire, and this is Discover CircRes, your on the go source for the most exciting discoveries in basic cardiovascular research. This program is copyright of the American Heart Association 2022. Opinions expressed by speakers in this podcast are their own, and not necessarily those of the editors or of the American Heart Association. For more information, visit ahajournals.org.  

In this episode of Scouting For Growth, Sabine VdL talks to Sebastian Pitzler – managing director of InsurLab Germany, a leading tech accelerator for startups wanting to enter the German market via Cologne. Before moving to the other side of the coin (meaning becoming an InsurTech startup enabler), Sebastian worked for a very well-known Insurance company, Ergo, a subsidiary company of MunichRe. He also has a background in IT strategy, he is a board member and a digital lab development expert.   KEY TAKEAWAYS Within our industry, there has been a great mind shift within the last 5-6 years. When I was responsible for the Ergo Lab in Berlin, in the beginning it was hard to talk with the procurement department to create a contract between a startup and an incumbent. The insurance industry was coming at it from an IT background that was focused on programming languages and self-developed software solutions. Then they began using standard software like Microsoft, and SAP, and finally, then they were open to working and collaborating with startups. It's great to have seen the volume of InsurTech startups increase steadily over the past few years, and that's because there are a couple of trends coming together: 1) The willingness and acceptance to support startups and corporate management attention that investments are necessary to build and grow these startup ecosystems. 2) The ability to see that startups are able to help and find solutions to major problems in a very short time period, which is something we realised in Germany during the Covid-19 pandemic. We have been able to create a lot of win-win situations and success stories where we could demonstrate that a startup solution could help to overcome, for example, the bottleneck of internal IT capacity. Networking the Insurance Industry is what our InsurLab Germany is about: To build a strong and reliable network for all parties, including enthusiasts who want to work on innovation and digitalization. From the beginning the design of the initiative was that we needed to bring together insurance companies on board as well as startups, IT providers, consultancy companies, and universities, all with different competencies to work on issues and topics like innovation and digitalisation. By setting up the InsureNXT Conference, our goal was clear. We wanted to ensure that the focus was not only on insurance, startups, and tech companies. We also wanted to include the cross-industry and science dimensions because it's logical if you want to develop innovation and digitalization for insurance in an ecosystem economy, you need to involve different parties. It's great to see how cross-industry partners are joining companies as networks like Garmin, Volvo, and Lufthansa Systems, all collaborating with our startups!   BEST MOMENTS ‘I'm not the classical insurance guy, I'm more of a tech enthusiast.' ‘During the past six months, we have supported 15 startups to develop and grow. We've supported them with over 60 mentors from our insurance and expert networks. Those connections helped develop over 40 projects. And some are already up and running as products on the market.' ‘Corporations want to innovate but avoid risks, and the startups want to grow quickly, but sometimes they speak different languages and we need to be a translator or build bridges between both those worlds to understand the different needs and perspectives.' ‘Digitalisation is about more than technology, it's about mind shift, agility, customer centricity on a new level. That's why it was so important, from scratch, to build InsurLab Germany as a network of different parties and drivers besides the member network that we have created and our partner network.'   ABOUT THE GUEST Sebastian Pitzler is Managing Director of InsurLab Germany, and this since March 2018. Previously, he was head of the ERGO Digital Lab in Berlin and was responsible for setting up and expanding this innovation laboratory in the Berlin start-up scene. LinkedIn: https://www.linkedin.com/in/pitzler/  Website: https://insurlab-germany.com/en/insurlab/    ABOUT THE HOST Sabine is a corporate strategist turned entrepreneur. She is the CEO and Managing Partner of Alchemy Crew, a venture lab that accelerates the curation, validation, and commercialization of new tech business models. Sabine is renowned within the insurance sector for building some of the most renowned tech startup accelerators around the world working with over 30 corporate insurers and accelerating over 100 startup ventures. Sabine is the co-editor of the bestseller The INSURTECH Book, a top 50 Women in Tech, a FinTech and InsurTech Influencer, an investor & multi-award winner.  Twitter: SabineVdL LinkedIn: Sabine VanderLinden Instagram: sabinevdLofficial Facebook: SabineVdLOfficial TikTok: sabinevdlofficial Email: podcast@sabinevdl.com Website: www.sabinevdl.comThis show was brought to you by Progressive Media

Dr. Miriam Merrill, AD at Pomona Pitzer Colleges, visits @1QLeadership in a conversation that covers hiring for fit and evaluating those hires. The discussion takes a wide diversion as Merrill gives us her way of escaping college athletics every year by attending the national bartenders convention. The episode wraps with her thoughts on using restorative justice concepts in college athletics.

Today on the Rarified Heir Podcast we bring you Richard Duggan, son of the late and great character actor Andrew Duggan. There were so many jumping off points actor who had almost 200 acting credits to his name on Broadway, television and film, we simply chose to jump right in. Andrew Duggan was known for a variety of roles in war films, Westerns, horror movies. For film buffs, he starred in films like Seven Days in May with Burt Lancaster and Kirk Douglass. and In Like Flint with James Coburn. For TV fans, Duggan starred in everything from Alfred Hitchcock Presents to Lancer which plays a major role in Quentin Tarantino's Once Upon a Time in Hollywood. He was the voice of Bud Light for years as well as the Clio winning “Friend of the Family (Rust in Peace.” He starred on stage in The Rose Tattoo and Fragile Fox. He even starred in TV movies like The Deadliest Season with Meryl Streep in her first role and Rich Man, Poor Man. And that doesn't even begin to tell the story of his roles in The Incredible Mr. Limpet, Doctor Detroit or F-Troop. We talk about Richard's years growing up in Westwood where we find out he and our host went to the same high school as well as Richard's years acting and doing improv which led to roles in Troma's Toxic Avenger, Sam Arkoff's Q: The Winged Serpent, and Larry Cohen's It's Alive!. Most importantly, this might be the only podcast where you learn that Robin Williams studied Improv at the Pitzer colleges, Richard's alma mater. It's all next, when we talk to Rick Dalton, I mean Richard Duggan, on the Rarified Heir Podcast. Everyone has a story.

Episode 98  is the first  of the last  two episodes on the autopsy,  and these two episodes cover one of the most explosive and controversial topics related to the goings on at Bethesda.  The question of whether  Lieutenant Commander William Bruce Pitzer engaged in taking a clandestine film of the autopsy that night and was engaged in a possible plan to expose evidence that would have blown the case wide open and  which most certainly would have  affirmed that JFK was shot from the front,  thereby confirming the existence of a  conspiracy. There is much more to reveal, so join us in this 33rd  episode related to the autopsy as we wind down this series and begin to open the next chapter in our journey that is JFK the Enduring Secret.  Join us for the whole series of episodes about the fantastic goings on that encompass this part of the JFK story.  There are  more direct forensics to come in later  forensics episodes.  Stay tuned,  and eventually we'll explore  more of the physical evidence involving use and ownership of the  Mannlicher Carcano rifle and  evidence  recovered from the Presidential limousine, as well as damage done to the vehicle.  Our episodes have now begun  to explore  an array of matters that  dive into a deeper  darkness  related to what  went on that day in Dallas and in the  period before and after the assassination.  Matters   that possibly point  to a  wider  and more sinister  plot to kill the president and  that clearly call into question the theory that there was a  lone assassin.   Complex cases without  an eyewitness that can actually identify the shooter make the forensic and circumstantial evidence that much more important.  Ironically, problems abound with much of the evidence in this case. Evidence that is complex, incomplete and sometimes conflicting. Even as early as 1964, rumors and serious concerns over  the lone gunman theory and the evidence that might contravene it,  were becoming a major concern for the government and the commission. Conspiracy theories were contrary to the government's stated narrative from the very beginning. Stay tuned as there are many more episodes to come!This series comprehensively explores the major facts,  themes, and  events leading up to the assassination in Dealey Plaza and the equally gripping stories surrounding the subsequent investigation. We  review  key elements of the Warren Commission Report , and the role of the CIA and FBI. We explore the  possible involvement of the Mafia in the murder and the review of that topic by the government's House Select Committee on Assassinations in the 1970's. We explore the Jim Garrison investigation and the work of other key figures such as Mark Lane and others. Learn more about Lee Harvey Oswald the suspected killer and Jack Ruby the distraught Dallas night club owner with underworld ties and the man that killed Oswald as a national TV audience was watching.  Stay with us as we take you through the facts and theories in bite sized discussions that are designed to educate, and inform as well as entertain the audience. This  real life story is more fascinating than fiction. No matter whether you are a serious researcher or a casual student, you will enjoy the fact filled narrative and story as  we relive one of the most shocking moments in American History. An event that changed the nation and changed the world forever.

Welcome back to D3 Glory Days! It's been a bit since we last spoke but we're back with a few guys from Pomona-Pitzer. On today's episode of The Double, we speak with Colin Kirkpatrick, Lucas Florsheim, and Bennett Booth on Pomona's national title in xc and how the season is going so far. The team has 16 guys under 15min in the 5k and just added their 17th last night. They speak highly of the team culture as it's a community that lifts each other up. While they were not allowed on campus for all of the 2020-2021 school because of COVID, the team lived and trained together all across the country. A big group was in Asheville, NC and they contribute that time together as a big catalyst for their success. On top of not being on campus for that school, their coach from the 2019 XC National Championship team, Jordan Carpenter, left for BU. Stepping in to replace him was their assistant coach, Kyle Flores. They speak highly of the transition and how well Kyle has done given these circumstances. You can get a sense that the strong team culture didn't they a school year a part and a new coach change the trajectory of the program. This was a fun a conversation to get a better idea of what happening over in California. One big takeaway is how proud they are of their team, their conference and being D3 athletes. They talked about getting excited for other schools running well because it helps the collective of D3 running. Pomona will be a force to reckon with next fall as 5/7 will return and more than half of the 16 under 15 are underclassmen. While they wanted to talk about the team success, here is what each guy has ran this season so far: Colin Kirkpatrick - 8:53 (steeple), 14:23 Lucas Florsheim - 14:13, 29:55 Bennett Booth - 1:49, 4:05(mile), 14:36 D3 Glory Days Patreon We launched a Patreon! As we said, we will never go behind a paywall - so any support is greatly appreciated. This past season was a great undertaking in our labor of love. We enjoy bringing you this content and we realized we could do so much more with a little bit of backing. We want to ensure D3 gets the coverage it deserves and keeping this website paywall free! If you have enjoyed this podcast and the articles we have put, please consider becoming a Patreon of D3 Glory Days. In full disclosure, the money will go directly into the show: equipment, subscriptions we need, and most importantly, money to our writers. If you are able, we would appreciate your support. How to Support D3 Glory Days As always, we really appreciate your support of this podcast. If you'd like to help spread the word, share the podcast with a friend, or leave us a review on Apple Podcasts or leave a rating on Spotify! We launched a live D3 Track Show. Subscribe to our YouTube channel so you don't miss it. If you would like to help support the podcast or say thanks to our writers, please consider making a donation on the D3 Glory Days Venmo. This helps offset some costs, hosting services, and help out our new writers. If you want to rep D3 Glory Days on your next run, head to our Merch Store. And finally, follow us on social media! We're on Instagram, Twitter and Strava.