Podcasts about cortical

Send us a text & leave your email address if you want a reply!Forget everything you thought you knew about pelvic floor exercises. In this episode, Leah and Dr. Willow sit down with Bel DeLorenzo, author of The Goh!ddess Method, to explore Pompoir, the ancient art of complete vaginal mastery that goes far beyond basic Kegels. Bel traces Pompoir's roots from the Devadasi temple dancers of sixth century India through the ping pong shows of Thailand to the legend of Wallis Simpson, then breaks down the mechanics: twelve distinct zones of movement and sensitivity inside the vagina, built from combinations of vertical, horizontal, and sagittal muscle contractions with names like milking, whipping, squeezing, and the lock. She explains how this kind of pelvic floor training saved her own relationship during a pandemic lockdown, why it can dramatically increase orgasm intensity and arousal, and how it connects to cervical orgasms through the vagus nerve and to a process she calls cortical remapping, where focused muscle training essentially turns up the resolution on your brain's pleasure map. The conversation also covers safety, including how to avoid a hypertonic pelvic floor, and touches on early research into non-ejaculatory, multi-orgasmic training for men. It's a deep, funny, and genuinely educational look at an under-discussed piece of female sexual anatomy and what becomes possible when you learn to use it with real precision.EPISODE HIGHLIGHTS✳️ Pompoir is complete vaginal mastery: twelve zones, three axes of movement, and skills like milking, whipping, and the lock that go way beyond a basic Kegel✳️ The pelvic floor connects to way more than pleasure: posture, squat strength, balance, and running form all showed up in Bel's own training✳️ Cervical orgasms bypass the spinal cord entirely through the vagus nerve, which may explain why they feel so emotional and whole body✳️ Cortical remapping means you're not growing new pleasure receptors, you're sharpening the brain's map of the ones you already have✳️ Pelvic floor training isn't just for women: early research on men points to multiple non-ejaculatory orgasms in a single encounter✳️ Safety matters: breathing, proper rest, and stretching are essential to avoid a hypertonic, overly tight pelvic floorLINKS & RESOURCES MENTIONED IN THE EPISODE CAN BE FOUND ON THE WEBSITE: https://www.sexreimagined.com/blog/pompoir-pelvic-floor-exercises  The Couples Sacred Spot Retreat | Santa Barbara, Nov 6-8 We are bringing our most intimate couples workshop to California. Over three days, you will learn Sacred Spot Massage, Erotic Attunement, sensual touch as a somatic practice, and the ritual skills that change the way partners meet each other in the body. Ten couple spots only. Register HereSupport the showPlease help support the production costs of the show! Donate now: https://www.buzzsprout.com/2032242/supporters/newFREEBIE- Introduction to Tantric Kissing Video and WorkbookSxR WebsiteDr. Willow's WebsiteLeah's Website 

In this episode, we're joined by Dr. Niels Niethard from the University of Tübingen to explore what sleep looks like at the level of cortical microcircuits — and how excitation and inhibition are dynamically reconfigured across brain states.Niels walks us through how excitatory pyramidal neurons interact with distinct inhibitory interneuron populations, including somatostatin (SST) and parvalbumin (PV) cells. We discuss how these cell-type-specific interactions shift from wakefulness to non-REM sleep and into REM, creating fundamentally different circuit configurations across sleep stages.We discuss how sleep spindles, slow oscillations, and REM sleep each create distinct configurations of dendritic and somatic inhibition. Niels explains how spindle timing relative to slow oscillation peaks influences synaptic plasticity and how these processes support selective memory consolidation.The conversation also touches on his work on synaptic downscaling in cortical and hypothalamic networks, the potential link between AMPA receptor regulation and sleep pressure, and how sleep interacts with feeding-related circuits and metabolic state in mice.This episode offers a detailed, cell-type-specific perspective on how excitation and inhibition are balanced across sleep stages, revealing the microcircuit mechanisms underlying memory, synaptic downscaling, and brain homeostasis.Find out more about Dr. Niethard's lab and see relevant publications below:Cortical circuit activity underlying sleep slow oscillations and spindles. PNAS, 2018Slow-wave sleep drives sleep-dependent renormalization of synaptic AMPA receptor levels in the hypothalamus. PLOS Biolology, 2024Cell-type specific dynamics of calcium activity in cortical circuits over the course of slow wave sleep and rapid eye movement sleep. Journal of Neuroscience, 2021Check out our NaPS website to find out more about the podcast, our research and events. This recording is the property of the Sleep Science Podcast and not for resale.

Elly Nedivi and Josiah Boivin discuss their paper, "Cortical Somatostatin Innervation Follows a Unique Experience-Independent Developmental Trajectory," published in Vol. 46, Issue 6 of JNeurosci, with Reviewing Editor Serena Dudek. Find our upcoming webinar schedule here. With special guests: Elly Nedivi and Josiah Boivin Hosted by: Serena Dudek On Neuro Current, we delve into the stories and conversations surrounding research published in the journals of the Society for Neuroscience. Through its publications, JNeurosci, eNeuro, and the History of Neuroscience in Autobiography, SfN promotes discussion, debate, and reflection on the nature of scientific discovery, to advance the understanding of the brain and the nervous system.   Find out more about SfN and connect with us on BlueSky, X, Instagram, and LinkedIn. 

This Week In Startups is made possible by:Deel https://deel.com/twistQuo https://quo.com/TWiSTLinkedIn Jobs https://LinkedIn.com/twistToday's show:Cortical Labs is the world's first company selling biological computers. Their CL1 fuses lab-grown human neurons (derived from stem cells, not actual folks) with silicon hardware to create Synthetic Biological Intelligence (SBI).Founder Dr. Hon Weng Chong walks us through how the system works and why neurons are more efficient than GPUs at reinforcement learning. (Also… is this computer alive?)PLUS Pyka co-founder and CEO Michael Norcia explains the various uses for his autonomous aircraft, from crop-spraying drones in Brazil to a a hybrid-electric defense UAV for the military.Guests:Cortical Labs: ****https://corticallabs.com/Dr. Hon Weng Chong on X: https://x.com/dr1337Pyka: https://www.flypyka.com/Pyka on Instagram: https://www.instagram.com/flypyka/?hl=enFurther Reading:2022 Pong paper in Neuron: https://www.cell.com/neuron/fulltext/S0896-6273(22)00806-62017 Paper: “Attention is All You Need”; https://arxiv.org/abs/1706.03762The “Barista Test” for Artificial Intelligence: Chris Rourk: https://medium.com/predict/the-turing-test-is-so-last-century-the-barista-test-for-artificial-general-intelligence-faf91034fa8cNotable Links:Playing “DOOM” on CL1: https://www.youtube.com/watch?v=yRV8fSw6HaEDayOne Data Center: https://dayonedc.com/NeurIPS 2026 Conference: https://neurips.cc/Neuralink: https://neuralink.com/CliniCloud Digital Stethoscope and Thermometer: https://www.design-industry.com.au/clinicloudAir Force Research Laboratory (AFWERX): https://afwerx.com/Joby Aviation: https://www.jobyaviation.com/Prime Movers Lab: https://www.primemoverslab.com/Timestamps:0:00 What is "biological computing"?2:49 Cortical's new $30 million raise4:15 The world's first biological data center9:48 Deel - Founders scale faster on Deel. Set up payroll for any country in minutes, hire anyone anywhere, get visas handled fast, and get back to building. Visit https://deel.com/twist to learn more.10:51 Biological computers have a learning advantage19:43 Quo (formerly OpenPhone) - Quo gives you a clean, modern way to handle every customer call, text, and thread all in one place. Try it free at https://quo.com/TWiST29:15 LinkedIn Jobs - Hire right, the first time. Post your first job and get $100 off towards your job post at https://LinkedIn.com/twist38:46 From paper airplanes to Group 4 UAVs52:20 Introducing the DropShip defense drone58:28 How regulations block US drones1:00:40 Why Pyka builds everything in-houseSubscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisCheck out all our partner offers: https://partners.launch.co/Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason's suite of newsletters: https://substack.com/@calacanisFollow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.com

Behzad Iravani and Josef Parvizi discuss their paper, "Intracranial Recordings of the Human Orbitofrontal Cortical Activity during Self-Referential Episodic and Valenced Self-Judgments," published in Vol. 44, Issue 11 of JNeurosci, with Reviewing Editor Erin Rich. Find our upcoming webinar schedule here. With special guests: Behzad Iravani and Josef Parvizi Hosted by: Erin Rich On Neuro Current, we delve into the stories and conversations surrounding research published in the journals of the Society for Neuroscience. Through its publications, JNeurosci, eNeuro, and the History of Neuroscience in Autobiography, SfN promotes discussion, debate, and reflection on the nature of scientific discovery, to advance the understanding of the brain and the nervous system.  Find out more about SfN and connect with us on BlueSky, X, Instagram, and LinkedIn.   

Today's episode is all about how childhood literally shapes the brain.Our most important experiences – from learning to read, to the growing complexity of our social lives at school, and even the video games we play – leave physical traces in how our brains get organized that shape how we see the world as adults.But how does the brain actually know what parts of our lives are actually important enough to reorganize around? How do particular experiences get under the hood to leave their mark on the developing brain?Today's guest, Stanford psychology professor Kalanit Grill-Spector, has spent her career trying to answer these questions. She's has been imaging children's brains – from infants to teenagers – to watch this reorganization unfold. Her work focuses on how our visual experience as children shapes our brains and how we see the world – what she and her team have found is not always what they expected.Learn MoreThe Vision and Perception Neuroscience Lab at Stanford Humanities and SciencesBrain's face recognition area grows much bigger as we get older (New Scientist, 2017)Neuroscientists use AI to simulate how the brain makes sense of the visual world (Wu Tsai Neurosciences Institute, 2025)Bridging nature and nurture: The brain's flexible foundation from birth (Wu Tsai Neurosciences Institute, 2025)Extensive childhood experience with Pokémon suggests eccentricity drives organization of visual cortex (Nature Human Behavior, 2019)Cortical recycling in high-level visual cortex during childhood development (Nature Human Behaviour, 2021)A unifying framework for functional organization in early and higher ventral visual cortex (Neuron, 2024)The emergence of visual category representations in infants' brains (eLife, 2024)White matter connections of human ventral temporal cortex are organized by cytoarchitecture, eccentricity and category-selectivity from birth (Nature Human Behaviour, 2025)Send us a text!Thanks for listening! If you're enjoying our show, please take a moment to give us a review on your podcast app of choice and share this episode with your friends. That's how we grow as a show and bring the stories of the frontiers of neuroscience to a wider audience.We want to hear from your neurons! Email us at at neuronspodcast@stanford.eduLearn more about the Wu Tsai Neurosciences Institute at Stanford and follow us on Twitter, Facebook, and LinkedIn. 

*E15 is a priority for sorghum producers.   *The Trump administration is taking action to help lower fertilizer costs.  *Workers at the JBS beef processing plant in Greely, Colorado are officially on strike.  *The Rio Grande Valley Livestock Show is underway.  *The crazy weather continues across Texas.  *The Trump administration has taken action to ease fuel and fertilizer prices.  *Thousands of young people are participating in the Houston Livestock Show.  *Cortical steroids are commonly used in equine joints.  

This interview is brought to you in partnership with Eisai and is part of the Journey to Diagnosis series.Eisai: https://www.eisai.com/index.htmlJourney to Diagnosis: https://beingpatient.com/journey-to-diagnosis/Andrew Reid was 56 when he was diagnosed with early-onset Alzheimer's after unexplained changes that affected his work, driving, and daily functioning. He lives with a rare form of the disease called Posterior Cortical Atrophy (PCA), which primarily affects visual processing. Before his diagnosis, Andrew built a career in management and leadership as the founder and CEO of Big Fish Interactive, a leadership training firm focused on guiding organizations through positive change. He's also a gold medalist in the European Dragon Boat Championships. Andrew and his wife, Karina, are committed to sharing their story to educate others about early-onset Alzheimer's, reduce stigma, and amplify the voices of young families facing the disease. Andrew has found strength in an improv acting group and has become a passionate advocate for others living with young-onset Alzheimer's.In this conversation with Being Patient's Mark Niu, Andrew and Karina describe the emotional toll of uncertainty and the importance of getting the right diagnosis. They discuss the realities of living with PCA and strategies to make daily life safer and more manageable, from visual cues in the home to finding new forms of connection through humor, community, and creative outlets like improv. Together, they exemplify how resilience and support can help families keep moving forward even as the disease changes everyday life.------If you loved watching this Live Talk, visit our website to find more of our Alzheimer's coverage and subscribe to our newsletter: https://www.beingpatient.com/Follow Being Patient: Twitter: https://twitter.com/Being_Patient_Instagram: https://www.instagram.com/beingpatientvoices/Facebook: https://www.facebook.com/beingpatientalzheimersLinkedIn: https://www.linkedin.com/company/being-patientBeing Patient is an editorially independent journalism outlet for news and reporting about brain health, cognitive science, and neurodegenerative diseases. In our Live Talk series on Facebook, former Wall Street Journal Editor and founder of Being Patient, Deborah Kan, interviews brain health experts and people living with dementia. Check out our latest Live Talks: https://beingpatient.com/live-talks/

We have a fantastic show for you. George of the World Ablaze Podcast joined us and we got deep in the news with Iran, the shut down of the Stait of Hormuz, and the troubled past of Iran and why it's important that the terrorist IRGC be overthrown this time. Canada is breaking records for assisted suicides. They're proudly celebrating 100K customers, I mean people being euthenized. We discuss how it's being used and how social credit scores maybe applied down the road. AI is still in the news. We discuss Anthropic's mess of a system and how they are not playing well with the US government's Department of War.  Did you know that Cortical labs is teaching hundreds of thounds of brain cells to play Doom? Well you're going to hear about it here. Lot's more to discuss because the world is defintily a blaze.  Make sure you follow George at https://www.worldablazepodcast... Big thanks to him for joining us and to all of our listeners who joined us Saturday!Become a supporter of this podcast: https://www.spreaker.com/podcast/razor-wire-news--5683729/support.www.razorwirenews.com

Today's podcast features 3 amazing guests with professional and/or personal experience in working with children with Down syndrome and Central Auditory Processing Disorder (CAPD) and/or Cortical Visual Impairment (CVI).   Maurice Belote has decades of expertise in the field of Deafblindness. Belote is a Deafblind specialist, Co-chair of the National Coalition on Deafblindness, adjunct faculty for two teacher training programs, and retired Project Coordinator for California Deafblind Services. lse Willems is the Senior Director of the CVI Center at Perkins School for the Blind.  She has worked at Perkins since 2010, working with students with visual impairments, dual sensory loss, and multiple disabilities, as both a Teacher of Students with Visual Impairments (TVI) and a Teacher of the Deafblind.  Jennifer Saenz, DO, MPH, a primary care physician and parent of a child with dual processing challenges and Down syndrome. Suggested Resources: https://www.perkins.org/cvi-now/ https://makeiteasiertosee.co.uk/ Article (available for purchase): Facilitating Listening Skills in Children who are Visually Impaired with Additional Disabilities of Deafblindness   If you would like to suggest a topic for us to cover on the podcast, please send an e-mail to DownSyndromeCenter@chp.edu. If you would like to partner with the Down Syndrome Center, including this podcast, please visit https://givetochildrens.org/downsyndromecenter. We are thankful for the generous donation from Caring for Kids – The Carrie Martin Fund that provides the funding for the podcast recording equipment and hosting costs for this podcast.

Dr. Mario Senden is an assistant professor in the Department of Cognitive Neuroscience at Maastricht University in the Netherlands, where he has spent his entire academic career. He received his bachelor's in psychology in 2009 and his PhD in cognitive computational neuroscience in 2016, both from Maastricht. A pioneer in biophysics-aware deep learning, Mario is known for his work on how large-scale brain networks support communication, integration, and perception. His research spans mesoscale laminar microcircuits to the macro-scale connectome, and his functional whole-brain modeling framework combines large-scale anatomical structure with local dynamics and goal-driven computation — asking not just whether a dynamical regime is biologically plausible, but whether it actually supports perceptual and cognitive function.In this episode, Peter and Mario explore the cutting edge of computational neuroscience and whole-brain modeling. They discuss Mario's influential work on rich club networks, which showed how highly connected cortical hubs dynamically gate information flow during tasks, as well as the principles behind oscillatory behavior in neural systems. A central focus of the conversation is Mario's most recent paper, "The Evolving Landscape of Neuroscience," submitted to Aperture Neuro — a sweeping meta-scientific analysis of roughly half a million neuroscience articles published between 1999 and 2023. Using text embeddings, semantic clustering, and large language models, Mario mapped the structural organization of the field and identified emerging trends and future directions. The conversation also touches on the promise of interdisciplinary approaches, the growing role of AI tools in neuroscience research, and the broader challenge of integrating theories and data across scales and domains to truly understand the brain.We hope you enjoy this episode!Chapters:00:00 - Introduction to Dr. Mario Senden05:11 - Journey from Psychology to Computational Neuroscience10:01 - Understanding Cognitive Computational Neuroscience14:09 - Limits of Current Models in Cognitive Computational Neuroscience20:44 - Exploring the Rich Club Concept in Brain Networks29:22 - The Interplay of Cortex and Subcortex42:44 - Oscillatory Behavior and Network Coordination48:41 - Multi-Scale Modeling in Neuroscience57:49 - Exploring the Evolving Landscape of Neuroscience01:21:08 - Advice for Young ScientistsWorks mentioned:42:19 - Senden et al. (2017). Cortical rich club regions can organize state-dependent functional network formation by engaging in oscillatory behavior. https://doi.org/10.1016/j.neuroimage.2016.10.04448:27 - Pronold et al. (2024). Multi-scale spiking network model of human cerebral cortex. https://doi.org/10.1093/cercor/bhae40948:27 - Senden et al. (2024). Modular-integrative modeling: a new framework for building brain models that blend biological realism and functional performance. https://doi.org/10.1093/nsr/nwad31857:50 - Senden, M. (2025). The Evolving Landscape of Neuroscience. https://doi.org/10.1101/2025.02.13.638094Episode producers:Ömer Faruk Gülban, Xuqian Michelle Li

One of four language-responsive cerebellar regions may encode meaningful information, much like the cortical language network in the left hemisphere, according to a new study.

Was ist die Cortical Silence Periode? Wieso verändert sich mit Chiropraktik die Muskelkraft und wie arbeitet das Gehirn wirklich? Alexander Brand MSc und David Morton PhD gehen neuen Fragen nach.Zu MANA Chiropraktik: ⁠⁠⁠⁠⁠⁠⁠⁠https://www.mana-chiropraktik.de⁠⁠⁠⁠⁠⁠⁠⁠Zu Morton Chiropraktik Coburg: ⁠⁠⁠⁠⁠⁠⁠⁠https://www.morton-chiropraktik.de⁠⁠⁠⁠⁠⁠⁠⁠Zu Chiropractic Masterclass: ⁠⁠⁠⁠⁠⁠⁠⁠https://www.chiropracticmasterclass.de

Neuronal activity induced by the psychedelic drug strengthens inputs from sensory brain areas and weakens cortico-cortical recurrent loops.

In this episode of Quah (Q & A), Sal, Adam & Justin answer four Pump Head questions drawn from last Sunday's Quah post on the @mindpumpmedia Instagram page. Mind Pump Fit Tip: Our favorite unconventional workout hacks. (2:22) New military technology that should terrify you. (24:34) AI's demonic spirit. (29:50) Comet or extraterrestrial? (32:12) The remarkable studies using binaural beats. (37:15) Overprescribed medications for kids. (39:14) Takeaways from Scott Donnel's course. (45:38) Joovv's CRAZY Black Friday deals! (49:14) AI can be a validation machine. (49:46) Guilty pleasures. (54:03) #Quah question #1 – What are some tips for feeling the rear delts? I watch the Mind Pump videos and end up feeling it in my side delts. I'm not sure if I need to round my back more and/or pull my shoulders back while rounding. (58:41) #Quah question #2 – How can I get stronger with squats? I'm squatting every week, but I just don't seem to make any progress. Although the reps are heavy and exhausting, I don't really feel my legs. Also, my mind prevents me from lifting heavier weights for fear that I can't get up from the squat. Any suggestions? (1:00:37) #Quah question #3 – As a dental hygienist, how can I be ergonomically preventative in my career to protect my wrist, shoulder, and neck? (1:04:15) #Quah question #4 – What's the number one thing this career has taught you about yourself? (1:05:15) Related Links/Products Mentioned Visit Brain.fm for an exclusive offer for Mind Pump listeners. ** Get 30 days of free access to science-backed music. ** Visit Joovv for an exclusive offer for Mind Pump listeners! ** From 11/7-12/1 save up to $1,000 on a new Joovv system. 0% financing available with payments starting at as little as $38 a month. Code MINDPUMP at checkout. ** BLACK FRIDAY SALE: 60% off ALL Programs, Guides, and MODs **Code BLACKFRIDAY at checkout** Mind Pump Store Z Press to take Your Shoulder Development to the Next Level – Mind Pump TV Bottoms Up Kettlebell Press Tutorial for SVKO Wild Card Event Build your Rear Delts with this Cable Fly – Mind Pump TV Unconventional Weight Training Exercises that can Help you Pack on Muscle X-BAT VTOL CCA: Shield AI's New Stealth Combat Drone New 'Oumuamua'? Why Scientists Are Watching 3I/ATLAS Closely Rapid modulation in music supports attention in listeners with attentional difficulties Cortical activity patterns in ADHD during arousal, activation and sustained attention Mind Pump #2685: How to Raise a Successful Family with Scott Donnell Fig and Eagle Visit Seed for an exclusive offer for Mind Pump listeners! **Promo code 25MINDPUMP at checkout for 25% off your first month's supply of Seed's DS-01® Daily Synbiotic** Mind Pump #2135: Barbell Squat Masterclass Mind Pump #2567: Women Who Lift: Breaking Myths and Building Muscle Muscle Mommy Movement Mind Pump Podcast – YouTube Mind Pump Free Resources People Mentioned Scott Donnell (@imscottdonnell) Instagram  

The findings add fuel to the long-running debate over how an imbalance in excitatory and inhibitory signaling contributes to the autism.

Want to share your feedback? Send us a message!Dr. Hatun Zengin-Bolatkale, Assistant Professor in the School of Speech, Language, and Hearing Sciences at San Diego State University, joins host Sara MacIntyre, M.A., CCC-SLP, to discuss findings from a two-part research project examining emotional processing and control in children who stutter. Dr. Zengin-Bolatkale begins by sharing her background and what led her into the field of stuttering research. She then guides listeners through her work investigating the interplay between emotions and stuttering, drawing on multiple methods to better understand this complex relationship. The conversation highlights two key studies (referenced below), covering relevant background, study design, surprising and noteworthy findings, and the implications of the results. Dr. Zengin-Bolatkale closes by sharing exciting future areas of research and projects she has underway. Papers discussed:Zengin-Bolatkale, H., Key, A. P., & Jones, R. M. (2025). Cortical emotional reactivity, caregiver-reported emotional control, and stuttering frequency in young children. Journal of Fluency Disorders, 85, Article 106139. https://doi.org/10.1016/j.jfludis.2025.106139Zengin-Bolatkale, H., Conture, E. G., Key, A. P., Walden, T. A., & Jones, R. M. (2018). Cortical associates of emotional reactivity and regulation in childhood stuttering. Journal of Fluency Disorders, 56, 81–99. https://doi.org/10.1016/j.jfludis.2018.04.001Hatun Zengin-Bolatkale, Ph.D., CCC-SLP is an Assistant Professor in the School of Speech, Language, and Hearing Sciences at San Diego State University. She's a speech-language pathologist by training and has over a decade of experience across working clinically, teaching, and doing research in the field, with a focus on stuttering. She earned her master's in speech-language pathology from the University of Illinois and completed her Ph.D. at Vanderbilt University. Her work focuses on young children who stutter, with a special interest in how cognitive, emotional, and language-related factors influence the way stuttering develops—and why some children recover while others do not. In her research, she uses a variety of tools, from parent reports and behavioral observation to physiological measures like skin conductance, heart rate, and brain activity, to get a more complete picture of stuttering. Her ultimate goal is to support more informed and individualized approaches to assessment and treatment.

Support the show to get full episodes, full archive, and join the Discord community. Ann Kennedy is Associate Professor at Scripps Research Institute and runs the Laboratory for Theoretical Neuroscience and Behavior. Among other things, Ann has been studying how processes important in life, like survival, threat response, motivation, and pain, are mediated through subcortical brain areas like the hypothalamus. She also pays attention to the time course those life processes require, which has led her to consider how the expression of things like proteins help shape neural processes throughout the brain, so we can behave appropriately in those different contexts. You'll hear us talk about how this is still a pretty open field in theoretical neuroscience, unlike the historically heavy use of theory in popular brain areas throughout the cortex, and the historically narrow focus on spikes or action potentials as the only game in town when it comes to neural computation. We discuss that and I link in the show notes to a commentary piece Ann wrote, in which she argues for both top-down and bottom-up theoretical approaches. I also link to her papers about the early evolution of nervous systems, how heterogeneity or diversity of neurons is an advantage for neural computations, and we discuss a kaggle competition she developed to benchmark automated behavioral labels of behaving organisms, so that despite different researchers using different recording systems and setups, analyzing those data will produce consistent labels to better compare across labs and aggregated bigger and better data sets. Laboratory for Theoretical Neuroscience and Behavior. Social: @antihebbiann.bsky.social @Antihebbiann The Kaggle competition Ann developed to generalize behavior categorization. Related papersDynamics of neural activity in early nervous system evolution.Theoretical neuroscience has room to grow. Neural heterogeneity controls computations in spiking neural networks. A parabrachial hub for the prioritization of survival behavior. An approximate line attractor in the hypothalamus encodes an aggressive state. Read the transcript. 0:00 - Intro 3:36 - Why study subcortical areas? 13:30 - Evolution 15:06 - Dynamical systems and time scales 21:32 - NeuroAI 28:37 - Before there were brains 33:11 - Endogenous spontaneous activity 40:09 - Natural vs artificial 43:09 - Different is more - heterogeneity 45:32 - Neuromodulators and neuropeptide functions 55:47 - Heterogeneity: manifolds, subspaces, and gain 1:02:43 - Control knobs 1:09:45 - Theoretical neuroscience has room to grow 1:19:59 - Hypothalamus 1:20:57 - Subcortical vs "higher" cognition 1:24:53 - 4E cognition 1:26:56 - Behavior benchmarking 1:37:26 - Current challenges 1:39:46 - Advice to young researchers

*The current cattle market cycle will look very different than the last one.   *There's good news for Texas dove hunters.  *The Concho Valley is having a good crop year.   *It's been a great year to grow grass in the Texas Panhandle.*Peanut harvest is underway in South Texas.  *U.S. lawmakers may act on the Farm Bill when they return to Washington after the August recess.*Midwest corn farmers are growing an all-time record crop.  *Cortical steroids are commonly injected into horses' joints.  

Today's show:Alex is back with three more awesome interviews with founders on the bleeding edge of innovative tech.Dr. Hon Weng Chong walks us through the basics of biological computing and Cortical Labs' first-ever commercial computer running on living human cells.Turing founder Jonathan Siddarth unpacks the secrets of LLM benchmarking, and explains why even our most advanced tests need to get much much harder right away.Finally, Mercor founder Brendan Foody on how AI is about to reinvent the hiring process, and marrying the effectiveness of recruiters with the ease of online job boards.It's three — count 'em, three — can't miss TWiST interviews guaranteed to make you smarterTimestamps:(0:00) OpenAI's GPT-5: When is it coming out? Is it going to be TOO smart?(08:06) Cortical Labs' Hon Weng Chong on the electric connection between neuroscience and machine learning(10:20) Northwest Registered Agent. Form your entire business identity in just 10 clicks and 10 minutes. Get more privacy, more options, and more done—visit https://www.northwestregisteredagent.com/twist today!(11:27) Show Continues…(15:17) The extreme difficulty of going from the lab to a shippable product(20:00) .TECH: Say it without saying it. Head to www.get.tech/twist or your favorite registrar to get a clean, sharp .tech domain today.(21:05) Show Continues…(28:15) Why data is a factor of time(29:52) AWS Activate - AWS Activate helps startups bring their ideas to life. Apply to AWS Activate today to learn more. Visit aws.amazon.com/startups/credits(31:16) Show Continues…(42:44) Turing CEO Jonathan Siddarth explains why it's so important to keep benchmarking our LLMs(47:24) What it means when a model “saturates” a test, and why benchmarks need to get HARDER(50:22) What happens with the LLMs can answer all of our smartest questions?(53:44) AI Agents train in gyms? Wait, really?(01:01:33) Coding teaches models how to think, and more training mysteries don't understand(01:03:11) Brendan Foody from Mercor explains the “matching problem” that makes hiring such a pain(01:07:02) How Mercor combines a job board's distribution with the value of a recruitment agency(01:10:49) Brendan recalls building his first AI interviewer in his college dorm(01:20:16) Mercor has the opposite of a retention problem and crazy growthSubscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisThank you to our partners:(10:20) Northwest Registered Agent. Form your entire business identity in just 10 clicks and 10 minutes. Get more privacy, more options, and more done—visit https://www.northwestregisteredagent.com/twist today!(20:00) .TECH: Say it without saying it. Head to www.get.tech/twist or your favorite registrar to get a clean, sharp .tech domain today.(29:52) AWS Activate - AWS Activate helps startups bring their ideas to life. Apply to AWS Activate today to learn more. Visit aws.amazon.com/startups/creditsGreat TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason's suite of newsletters: https://substack.com/@calacanisFollow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.comSubscribe to the Founder University Podcast: https://www.youtube.com/@founderuniversity1916

Prof. Marina de Koning-Tijssen interviews Prof. Sabine Fuchs on the potential of prime editing as a future therapy for cortical myoclonus. This exciting new development holds promise for the treatment of rare genetic disorders such as GOSR2. In the interview, Prof. Fuchs provides valuable insights into the science and potential applications of this groundbreaking technique.

This Saturday, BENN - a Taipei-based producer, DJ and founder of Over My Body dance label - is taking over our Select series with a one-hour mix of his recent productions and current favourites, blending Asian influences with sharp broken beats. The set features tunes like ‘Shiny Surgery' by Cortical and ‘Veil of Dusk' by Yes Reven. BENN has been igniting dancefloors across several continents with his symbolic, explosive energy and avant-garde club productions. Over the past few years, BENN released several EPs and participated in many compilations from different labels worldwide, each showcasing an evolution of his technique, from synesthesia's tribal futurism to the organic natural pulses of Entheos.

Human neuroscience research has largely overlooked this spatial scale—which bridges cells and brain areas. But new advances in functional MRI technology are changing that.

Prof. Marina de Koning-Tijssen interviews Professors Anna Latorre and Shabbir Merchant on the topic of electrophysiology, with a focus on cortical myoclonus. Together they discuss the potential applications of electrophysiology for myoclonus in clinical practice. They also explore the complex interface between cortical myoclonus and epilepsy.

In this exclusive podcast interview, Denise Holt sits down with Brett Kagan, Chief Scientist at Cortical Labs, for an in-depth exploration into their groundbreaking synthetic biological intelligence (SBI) technology. Brett reveals the science behind their revolutionary CL1 system—the first commercial biological computer fusing live human neurons with silicon computing. We discuss how their DishBrain experiment validated Dr. Karl Friston's Free Energy Principle, the extraordinary energy efficiency of biological intelligence, and the significant implications for industries like drug discovery, personalized medicine, and robotics. Don't miss this insightful conversation, rich with first-hand stories and detailed explanations from the forefront of neuroscience and AI innovation. #CorticalLabs #CL1 #ActiveInferenceAIKey Topics:·  The CL1 System: How Cortical Labs successfully merged live human neurons with silicon chips to create the first synthetic biological intelligence computing system.·  DishBrain Experiment: Insights into the groundbreaking experiment validating Dr. Karl Friston's Free Energy Principle through neuron-based Pong gameplay.·  Energy Efficiency of Biological Intelligence: Understanding how biological neurons provide vastly superior energy efficiency compared to traditional AI systems.·  Ethical Implications: Brett Kagan's candid discussion on the responsible use of human neurons in research and their potential to reduce animal testing.·  Real-world Applications: The transformative impact of synthetic biological intelligence on drug discovery, personalized medicine, and robotics.Guest:Brett Kagan, Chief Scientific Officer at Cortical LabsHost: Denise Holt, CEO and Founder, AIX Global MediaHuge thank you to Brettfor being on our show! Discover more about Cortical Labs: https://corticallabs.com Looking for education resources and courses on Active Inference, the Free Energy Principle, and Spatial Web Technologies? Visit Learning Lab Central to find others around the world who are just as excited for this new shift in AI and computing:https://learninglab.emmersionpublishing.com #CorticalLabs #CL1 #FreeEnergyPrinciple#ActiveInferenceAi

Episode #122: Cortical Visual Impairment: The Most Confusing Blindness Explained

The practice of neurology is constantly changing, and the papers in this issue exemplify that trend. On this episode, journal editors Dr. Geraint Fuller and Prof. Philip Smith discuss their highlights from the latest issue of Practical Neurology, for February 2025. They begin with the editors' choice paper on stiff person syndrome, then speak about new guidance from the ABN on disease-modifying treatments for MS. There's also life-improving interventions for posterior cortical atrophy, changing attitudes towards stroke as a career option for neurologists, and management techniques for cryptococcal meningitis - including a resourceful substitute for India ink.  Read the issue: https://pn.bmj.com/content/25/1/1  Please subscribe to the Practical Neurology podcast on your favourite platform to get the latest podcast every month. If you enjoy our podcast, you can leave us a review or a comment on Apple Podcasts (https://apple.co/3vVPClm) or Spotify (https://spoti.fi/4baxjsQ). We'd love to hear your feedback on social media - @PracticalNeurol. Production by Letícia Amorim and Brian O'Toole. Editing by Brian O'Toole. Thank you for listening. 

Today, you'll learn about why you may want to consider letting yourself daydream, how a sense of humor might protect you from depression and anxiety, and the effects of caffeine on the performance of soccer players. Daydream Brain •“What Happens in the Brain While Daydreaming?” by Catherine Caruso. 2023. •“Is the role of sleep in memory consolidation overrated?” by Mohammad Dastgheib, et al. 2022. •“Cortical reactivations predict future sensory responses.” by Nghia D. Nguyen, et al. 2023. •“Why Daydreaming Is Good For Us.” by David B. Feldman Ph.D. 2017. Power of a Laugh •“Your type of humor might say something about your risk of depression and anxiety.” by Eric W. Dolan. 2023. •“Understanding the Association Between Humor and Emotional Distress: The Role of Light and Dark Humor in Predicting Depression, Anxiety, and Stress.” by Alberto Dionigi, et al. 2023. Caffeine & Soccer •“Caffeine highs and lows footballers should be aware of.” n.a. 2023. •“The effects of acute caffeine ingestion on decision-making and pass accuracy in young soccer players: A preliminary randomized controlled trial.” by Negar Jafari, et al. 2023. Hosted on Acast. See acast.com/privacy for more information.

Contact and collision athletes face a higher risk of recurrent anterior shoulder instability after surgical stabilization. The Latarjet procedure is often preferred given the high incidence of bony lesions. However, this stabilizing procedure, performed either open or arthroscopically, is met with concerns regarding complications and revision surgery rates.   In conclusion, the arthroscopic Latarjet procedure with suture button fixation allowed 82% of athletes with recurrent anterior shoulder instability to return to contact or collision sports. Patients with severe humeral bone defects have a higher risk of persistent anterior apprehension and decreased RTS. The arthroscopic-guided procedure with suture button fixation is safe; accurate, with a high rate of anatomic graft positioning and healing; and reliable, with a low recurrence rate.     Click here to read the article.

Join me for a summary looking into the increasingly popular topic of paediatric obstructive sleep apnoea, a review of orthodontic treatments available, and how effective they are in this growing field of both medicine and dentistry. This episode is a summary of Alberto Capriglio's lecture from the AAO and Carlos Flores Mir's lecture at the IOF earlier this year.     OSA - Defined upper airway dysfunction causing complete or partial airway obstruction during sleep   Sleep = Slow wave sleep – constructive phase of sleep (recuperation of the mind) ·      Growth hormones secreted ·      Glial cells within brain restored ·      Cortical synapses increase in number – Moberget 2019   Outcomes to paediatric patients of SDB: (AASM) ·      delays in development,  Poor academic performance, Aggressive behaviour, attention- deficit/hyperactivity disorder, , emotional problems in adolescence   First line medical treatment – adenotonsillectomy  ·      40% residual  OSA       Effect palatal expansion 1.        Roof the mouth = base of the nose - Increase in nasal airway volume - Reduction in OSA, if obstruction in naso-pharynx, 2.        Short term reduction in OSA (not cure AASM) a.        20% improvement in AHI, 85% of cases Villa 2015 b.        15% got worse by 20% c.        57.5% residual AHI greater than 1 - not resolution 3.        Caprioglio 2019 long term AHI return to initial scores, from 7 to 5 long term 4.        Change in metabolism when combined with Vit D3 a.        Vit D3 with RME increases reduction in AHI, sustained long term, Caprioglio 2019 AHI 61.9% Vs 35.5% long term     Expansion other outcomes -  school performance  Bariani 2024 ·      AJODO – RME improves academic performance – o   BEHAVOUR 1 of 8 parameters improved only for academic performance  - change small 0.68 o   COGNITIVE 1 in 8 improve       Mandibular advancement Move mandible forwards and open space behind the tongue – oropharynx ·      Anatomical – increase size of oropharangeal airway ·      YAnyAn 2019 mandibular advancement for pOSA systematic review:  1.75 AHI reduction (CI) −2.07, −1.44) – modest change ·      However long term use required of the paediatric patient     Orofacial features in children with obstructive sleep apnea.  Fagundes Flores-Mir 2022 o   No craniofacial features specific to pOSA – ANB, o   However medical diagnosis through polysomnography may under-estimate incidence, o   Broader diagnosis such as snoring, may over-estimate OSA   AADSM 2024 – consensus statement ·      Expansion o   Prevention: No consensus o   Management: No consensus o   Cure: Insufficient ·      Mandibular advancement o   Prevention, management, cure – unclear   More about OSA? To hear more about OSA, please check out the last interview on orthodontics in interview with Sanjivan Kandasamy, where we had a deep dive into OSA and where we are in our understanding today from the research Interview with Sanjivan Kandasamy on OSA                          

Fiser's work taught me how to think about grounding computational models in biologically plausible implementations.

In this episode, we're exploring the various ways stress affects your brain, both positively and negatively.We'll discuss the key differences between eustress (the beneficial kind) and distress (the harmful kind), and reveal practical strategies to manage chronic stress for better cognitive health.Whether you're dealing with daily pressures or long-term stress, this episode will arm you with knowledge to protect your brain and help you build resilience.What to Listen For:The key differences between eustress (positive stress) and distress (chronic stress).How chronic stress leads to memory loss, emotional difficulties, and increased Alzheimer's risk.The role of cortisol and the HPA axis in stress responses and brain health.How eustress boosts cognitive function, memory, and neuroplasticity.The dangers of prolonged cortisol exposure on brain structures like the hippocampus and amygdala.A study from Frontiers in Behavioral Neuroscience showing how moderate stress improves learning and memory.How chronic stress can trigger brain inflammation and accelerate cognitive decline.Practical strategies for reducing chronic stress: mindfulness meditation, social connections, and reframing stress as a positive force.The effects of chronic stress on the amygdala, prefrontal cortex, and hippocampus.Three actionable tips to protect your brain from the long-term effects of stress.Research Studies Referenced:McEwen BS (2007). "Physiology and neurobiology of stress and adaptation: central role of the brain." Physiol Rev, 87(3), 873-904. This paper explores how stress affects brain function and structure.Lupien SJ, et al. (2009). "Effects of stress throughout the lifespan on the brain, behaviour and cognition." Nat Rev Neurosci, 10(6), 434-445.Sousa N, et al. (2016). "Cortical and hippocampal circuitry changes under chronic stress: Implications for mood and cognition." Prog Neuropsychopharmacol Biol Psychiatry, 67, 1-14.Wilson, R. S., et al. (2007). "Chronic distress and incidence of mild cognitive impairment." JAMA Psychiatry, 68(2), 211-218Tang YY, et al. (2015). "The neuroscience of mindfulness meditation." Nat Rev Neurosci, 16(4), 213-225.RESOURCES: Access the FREE Masterclass: How To Optimize Your Sleep Order Amy's book Thoughts Are Habits Too: Master Your Triggers, Free Yourself From Diet Culture, and Rediscover Joyful Eating. Join our private Facebook group: Moxie Club Meetup Follow Amy on Instagram @habitwhisperer

Rachel Bennett travelled a path that many mothers with a child with Cortical/cerebral Visual Impairment (CVI) encountered. The diagnosis was a long time coming and when it was discovered new world opened up for her son, Henry. Now Rachel helps to support and advocate for other families like hers through CVI Now at the Perkins School for the Blind. Listen as Dr. Cathy encourages Rachel to tell her story as the first episode of Season Four on Feeling This Life.     Want to learn more about CVI Now and their resources?   CVI Now Website: CVINow.org  CVI Now on Instagram: @cvinow   Subscribe to the monthly CVI Now newsletter    Please give us your feedback using this survey link: ⁠https://educationutah.co1.qualtrics.com/jfe/form/SV_39OmBvMih6MlgNw⁠   Make a Donation to-   VIPS: ⁠https://secure.vips.org/np/clients/vips/donation.jsp?forwardedFromSecureDomain=1&campaign=495⁠   Anchor Center: ⁠https://www.anchorcenter.org/get-involved/donate/⁠     Get in touch with us!   Follow us on Facebook @Feelingthislifepodcast and Instagram @Feelingthislife   Email: ⁠feelingthislife@vips.org⁠   ⁠www.anchorcenter.org⁠   ⁠www.vips.org 

Radiology read to you! Frank reads Radiopaedia's focal cortical dysplasia article and does a little link surfing at the same time. Plus, Olympics closing ceremony, Tom Cruise, Snoop Dogg, Frank Steps Down, new Epileptogenic Brain Tumours Course and a chat about buzzwords.   Radiopaedia's FCD article  ► https://radiopaedia.org/articles/focal-cortical-dysplasia Epileptogenic Brain Tumour Course ► https://radiopaedia.org/courses/epileptogenic-brain-tumours-learning-pathway Radiopaedia 2024 Census ► https://bit.ly/r-census2024   Richard Feynamn on names ► https://www.youtube.com/watch?v=lFIYKmos3-s Radiopaedia Community chat ► http://radiopaedia.org/chat Become a supporter ► https://radiopaedia.org/supporters Get an All-Access Pass ► https://radiopaedia.org/courses/all-access-course-pass Andrew's X ► https://twitter.com/drandrewdixon Frank's X ► https://twitter.com/frankgaillard Ideas and Feedback ► podcast@radiopaedia.org   The Reading Room is a radiology podcast intended primarily for radiologists, radiology registrars and residents. 

How can we help people with prosthetic legs walk more easily and with less effort? In this episode of Neurocareers: Doing the Impossible!, we explore this question with Giacomo Valle, PhD, a leading researcher in the field of biomimetic brain-computer interfaces (BCIs) and bionic legs. Dr. Valle and his colleagues at ETH Zürich have developed an innovative biomimetic BCI that uses peripheral nerve stimulation to convey naturalistic touch sensations in bionic legs. This groundbreaking work has earned them a spot as one of the 12 finalists for the BCI Award 2023. Dr. Valle's research focuses on creating artificial communication with the brain through peripheral nerve stimulation, providing a more intuitive and natural sensory experience. His team developed a biomimetic neurostimulation framework inspired by nature, capable of "writing" physiologically plausible information back into the peripheral nervous system. Using an in-silico model of mechanoreceptors, they created biomimetic stimulation policies, which were tested alongside mechanical touch and common linear neuromodulations. In clinical trials, these techniques have shown significant improvements in mobility and reduced mental effort compared to traditional approaches. The neural responses produced by this innovative approach resemble those naturally induced, marking a significant advancement in assistive neurotechnologies. Dr. Valle's project, "Biomimetic BCI Conveys Naturalistic Touch Sensations via Peripheral Nerve Stimulation for Bionic Legs," represents a major leap forward in neuroengineering and bionics. With an educational background that includes a B.S. in Biomedical Engineering and an M.S. in Bioengineering from the University of Genoa, and a Ph.D. in Biorobotics from the Scuola Superiore Sant'Anna, Dr. Valle has extensive experience in this field. His career journey includes research positions at the École Polytechnique Fédérale de Lausanne and ETH Zurich, where he contributed to significant innovations in neuroprosthetics. As a co-founder of the medtech startup MYNERVA and now a Tenure-track Assistant Professor in Bionics at Chalmers University of Technology in Sweden, Dr. Valle's research focuses on neuroengineering and computational models aimed at restoring sensory feedback and understanding somatosensory processing and neural control of movements. Join us as Dr. Valle shares insights into his research, discusses his career path, and offers valuable advice for a successful BCI Award submission. Whether you're interested in the latest advancements in neuroengineering or seeking inspiration for your own scientific endeavors, this episode is packed with fascinating insights and expert guidance. About the Podcast Guest: Dr. Giacomo Valle holds  a position as an Assistant Professor in Bionics, Head of the Neural Bionics Laboratory at the Department of Electrical Engineering  | Life Bionics Chalmers University of Technology in Hörsalsvägen 11, SE - 412 96, Gothenburg, Sweden Sahlgrenska Universitetssjukhuset R-huset, plan 7, Länsmansgatan 28, 431 80 Mölndal Other Dr. Valle's affiliations: Cortical Bionics Research Group, USA: https://www.corticalbionics.com/ Co-founder MYNERVA  Wyss Zurich Translational Center | ETH Zurich, Weinbergstrasse 35, WEH 8092 Zurich Switzerland Contact Information: E-mail: valleg@chalmers.se  @NeuralBionicsLab socials: LinkedIn, X.   Open Positions: The Neural Bionics Lab (PI: Giacomo Valle) has available projects (6-12 months) starting this fall and next spring on: - Bidirectional neuroprosthetics - Implantable Brain-Computer Interfaces - Somatosensation & Touch - Neural stimulation for sensory restoration - Cortical & peripheral interfacing - Mechatronics for neurotechnology - Human neurophysiology Please contact us here or at valleg@chalmers.se sending your CV, transcript of records (Bachelor and Master) and motivation letter. Info about the projects on https://sirop.org/app/ Our projects are done in collaboration with Biological Sciences Division at the University of Chicago, CBRG, University of Zurich and MYNERVA. hashtag About the Podcast Host: The Neurocareers podcast is brought to you by The Institute of Neuroapproaches (https://www.neuroapproaches.org/) and its founder, Milena Korostenskaja, Ph.D. (Dr. K), a neuroscience educator, research consultant, and career coach for people in neuroscience and neurotechnologies. As a professional coach with a background in the field, Dr. K understands the unique challenges and opportunities job applicants face in this field and can provide personalized coaching and support to help you succeed. Here's what you'll get with one-on-one coaching sessions from Dr. K: Identification and pursuit of career goals Guidance on job search strategies, resume, and cover letter development Neurotech / neuroscience job interview preparation and practice Networking strategies to connect with professionals in the field of neuroscience and neurotechnologies Ongoing support and guidance to help you stay on track and achieve your goals You can always schedule a free neurocareer consultation/coaching session with Dr. K at https://neuroapproaches.as.me/free-neurocareer-consultation Subscribe to our Nerocareers Newsletter to stay on top of all our cool neurocareers news at updates https://www.neuroapproaches.org/neurocareers-news

A discussion of disorders of cortical visual processing with Drs. Kevin Yan, Vanessa Veloso and Jeremy Moeller. Special thanks for Drs. Sashank Prasad and Marc Dinkin for providing the inspiration and a framework for this discussion.Note: This podcast is intended solely as an educational tool for learners, especially neurology residents. The contents should not be interpreted as medical advice.

This is part 1 of my conversation with Stephanie Duesing. She shares how her son was diagnosed with Cerebral/Cortical Visual Impairment (CVI) as a teenager, and how this diagnosis has impacted their family. If you have an idea for a topic we should discuss on the podcast e-mail us: OurView4Life@gmail.com Learn More about CVI: https://www.nei.nih.gov/about/news-and-events/news/vision-loss-children-whose-eyesight-may-be-2020-requires-new-diagnostic-and-teaching-strategies https://www.optometrytimes.com/view/getting-to-the-heart-of-pediatric-vision-loss-and-blindness https://www.sciencedirect.com/science/article/abs/pii/S0028393221002359 https://www.npr.org/sections/health-shots/2014/05/26/314621545/the-blind-woman-who-sees-rain-but-not-her-daughters-smile#:~:text=You%20can%27t%20see%20a,stroke%20at%2029%20years%20old. https://cviscotland.org/  

  Phil Starr is a Professor of Neurological Surgery at University of California, San Francisco and a developer of implantable brain devices. At UCSF, he co-directs a multidisciplinary neurology/neurosurgery movement disorders clinic together with Dr. Jill Ostrem. I've been a long-time admirer of Phil's work and in this conversation we blaze through quite a few of his numerous publications. One key breakthrough and invention of Phils work has been to include Ecog recordings – both intraoperatively but also chronically – to investigate brain signals in various states. We talk about the Open Mind Consortium, Mentorship and the cross-pollination between academia and industry. One key highlight of Phils work is a paper which was accepted for publication in Nature Medicine, at the time of recording this just yesterday. In it, the three co-first authors Carina Oehrn, Stephanie Cernera and Lauren Hammer demonstrate the chronic use of a newly identified cortical physiomarker, which is now referred to as the finely tuned gamma activity. I hope you enjoy this conversation as much as I did, and thank you for tuning into Stimulating Brains!

Dr. Tesha Monteith and Dr. Messoud Ashina discuss the comparison between cortical morphometry to a large sample of people with migraine and healthy controls, as well as across migraine subtypes.  Show reference: https://www.neurology.org/doi/10.1212/WNL.0000000000209305  This podcast is sponsored by argenx. Visit www.vyvgarthcp.com for more information.

Dr. Tesha Monteith talks with Dr. Messoud Ashina about the comparison between cortical morphometry to a large sample of people with migraine and healthy controls, as well as across migraine subtypes. Read the related article in Neurology. This podcast is sponsored by argenx. Visit www.vyvgarthcp.com for more information. Disclosures can be found at Neurology.org.

The powerful new generation of AI tools that has come out over the past few years —  DALL-E, ChatGPT, Claude, Gemini, and the rest — have blown away our old ideas about what AI can do and raised questions about what it means for computers to start acting... intelligent?This week, we ask what the rise of these systems might teach us about our own biological intelligence — and vice versa. What does modern neuroscience have to say about how AI could become as flexible, efficient, and resilient as the human brain. Few people are better positioned to speak to the intersection of neuroscience and AI than today's guest: Surya Ganguli. Ganguli's lab produced some of the first diffusion models — which are at the foundation of today's AI revolution — and is now working to understand how complex emergent properties arise from biological and artificial neural networks. Ganguli is a member of the Neuroscience Theory Center at the Wu Tsai Neurosciences Institute, a Senior Fellow at Stanford's Institute for Human-Centered Artificial Intelligence (HAI), and an associate professor in Stanford's Department of Applied Physics. Further ReadingInterpreting the retinal neural code for natural scenes: From computations to neurons (Neuron, 2023)Beyond neural scaling laws: beating power law scaling via data pruning (arXiv, 2023)Cortical layer-specific critical dynamics triggering perception (Science, 2019)Stanford team stimulates neurons to induce particular perceptions in mice's minds (Stanford Medicine, 2019)What DALL-E reveals about human creativity (Wu Tsai Neurosciences Institute, 2023)Visit us!Want to learn more about AI and Neuroscience? Join us at Wu Tsai Neuro's annual symposium on October 17, 2024, which will showcase the frontiers of biological and artificial intelligence research. (More details coming soon!)Episode creditsThis episode was produced by Michael Osborne at 14th Street Studios, with production assistance by Morgan Honaker. Our logo is by Aimee Garza. The show is hosted by Nicholas Weiler at Stanford's Wu Tsai Neurosciences Institute. Send us a text!Thanks for listening! If you're enjoying our show, please take a moment to give us a review on your podcast app of choice and share this episode with your friends. That's how we grow as a show and bring the stories of the frontiers of neuroscience to a wider audience. Learn more about the Wu Tsai Neurosciences Institute at Stanford and follow us on Twitter, Facebook, and LinkedIn.

This “MOGcast” edition of the “Ask the Expert” podcast series is a collaborative episode titled, “MOGcast 2: Understanding Cortical Encephalitis.” Dr. Eoin Flanagan and Dr. Cristina Valencia Sanchez joined Julia Lefelar of The MOG Project and Dr. GG deFiebre of SRNA to discuss cortical encephalitis, its symptoms, and the connection to MOG antibody disease (MOGAD) [00:04:21]. Audience members asked about the distinction between ADEM and cerebral cortical encephalitis, their treatments, diagnostic methods, and long-term impacts [00:35:34]. Dr. Flanagan and Dr. Sanchez agreed that the preventive treatment approach remains similar regardless of the MOGAD phenotype [00:40:36]. The discussion touched on recent studies on the diagnostic utility of MOG antibody testing in cerebrospinal fluid, and ongoing research on treatments, including clinical trials for developing FDA-approved medications for MOGAD [00:43:05]. Dr. Flanagan and Dr. Sanchez addressed community questions on fulminant cortical involvement cases [00:50:00], the long-term effects of Rituximab treatment [00:51:23], anxiety attacks and mood swings in ADEM [00:53:34], and treatment decisions based on antibody levels [00:54:49]. Eoin Flanagan, MB, BCh is a Professor of Neurology and Consultant in the departments of Neurology and Laboratory Medicine and Pathology at the Mayo Clinic (Rochester, MN). He completed his medical school training at University College Dublin in Ireland in 2005. He did a medical residency in Ireland and then completed neurology residency, fellowships in neuroimmunology and a masters in clinical and translational science at Mayo Clinic (Rochester, MN). He works in the Autoimmune Neurology and Multiple Sclerosis Clinics and the Neuroimmunology Laboratory at the Mayo Clinic. His clinical expertise and research are focused on inflammatory myelopathies and their imaging patterns, myelin oligodendrocyte glycoprotein (MOG) antibody associated disorder, neuromyelitis optica spectrum disorders, autoimmune encephalitis, paraneoplastic neurologic disorders, and multiple sclerosis. He is principal investigator on an NIH RO1 grant studying MOG antibody associated disorder. Cristina Valencia Sanchez, MD, PhD is an Assistant Professor of Neurology and Senior Associate Consultant in the Department of Neurology at the Mayo Clinic (Phoenix, AZ). She completed her medical school training and PhD in Neuroscience at the Universidad Complutense de Madrid. She did a Neurology residency in the Hospital Universitario Clinico San Carlos and then completed Neurology residency and fellowships in ARZ Multiple Sclerosis and RST Autoimmune Neurology at the Mayo School of Graduate Medical Education, Mayo Clinic College of Medicine, in Arizona and Minnesota. The research interests of Dr. Valencia Sanchez focus on autoimmune disorders involving the central nervous system. These include neuromyelitis optica spectrum disorders, myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), autoimmune encephalitis, and paraneoplastic neurological syndromes. She is particularly interested in the neurological complications of immune checkpoint inhibitor cancer immunotherapy. The clinical trials that she leads at Mayo Clinic in Arizona are among the first studies that may lead to approval of new targeted therapies for MOGAD and autoimmune encephalitis. Additionally, Dr. Valencia Sanchez's clinical research allows for increased recognition of autoimmune neurological disorders. Also, her work is helping to avoid misdiagnosing autoimmune encephalitis in the clinical setting. Her research leads to earlier diagnosis and appropriate treatment to ultimately improve patient outcomes.

Dr. Pierre Vanderhaeghen is a Professor and Principal Investigator at VIB-KU Leuven Center for Brain & Disease Research. His lab studies the mechanisms of cortical development and brain evolution. He talks about species-specific neuronal development, human neuron excitability, and playing in a rock cover band!

*Texas Panhandle ranchers are recovering from the wildfires.  *National Sorghum Producers is accepting entries for the National Sorghum Yield Contest.   *The Texas NRCS announced an additional signup for the National Water Quality Initiative.  *Fed cattle prices remain strong, but Texas feedyards are finding it challenging to make a profit.*Agriculture cybersecurity was the topic of a recent House Ag Committee hearing.  *The 2024 hurricane season is expected to be strong.  *The Rolling Plains wheat crop is heading, and it looks pretty good.  *Cortical steroids are the most common drugs injected into the joints of performance horses.  

There are a lot of confusing things you can see on an MRI report, on an x-ray report or an ultrasound report when you're a runner with pain that you think might be a stress fracture.  One of those findings that may be reported on your medical imaging study is a thing called "cortical thickening." I want to explain what that is so you can better understand it in case you happen to see it on an MRI report, x-ray report or in your doctor's notes. What is cortical thickening that precedes a stress fracture?  Well, that's what we're talking about today on the Doc On The Run Podcast.   

Dr. David Fitzpatrick is Chief Executive Officer, Scientific Director, and Research Group Leader at the Max Planck Florida Institute for Neuroscience. The brain is important for so many aspects of our daily experiences, including what we perceive, what we think about, how we move, the decisions we make, and more. However, we still know relatively little about how the brain works and how it develops. David's goal is to dive deep into these basic science questions of how the brain works and how it develops. When David isn't hard at work at Max Planck, he spends his time hiking, biking, kayaking, and immersing himself in nature. He has also become a keen photographer, capturing captivating photos of the natural world and memorable moments in his life. David received his B.S. degree in Biology from Pennsylvania State University and his PhD in Psychology and Neuroscience from Duke University. He conducted postdoctoral research at the Medical University of South Carolina and then returned to Duke University as a member of the faculty. Before accepting his current positions at the Max Planck Florida Institute, David was the James B. Duke Professor of Neurobiology and Director of the Institute for Brain Sciences at Duke University. David has received numerous awards and honors over the course of his career for his outstanding research and teaching, including the 2011 Ellis Island Medal of Honor from the National Ethnic Coalition of Organizations, the Alfred P. Sloan Research Award, the Cajal Club Cortical Discoverer Award, the McKnight Neuroscience Investigator Award, and the Excellence in Basic Science Teaching Award from Duke University School of Medicine. David joined us for an interview to share his experiences in life and science.

Today, you'll learn about why you may want to consider letting yourself daydream, how a sense of humor might protect you from depression and anxiety, and the effects of caffeine on the performance of soccer players. Daydream Brain “What Happens in the Brain While Daydreaming?” by Catherine Caruso. 2023. “Is the role of sleep in memory consolidation overrated?” by Mohammad Dastgheib, et al. 2022. “Cortical reactivations predict future sensory responses.” by Nghia D. Nguyen, et al. 2023. “Why Daydreaming Is Good For Us.” by David B. Feldman Ph.D. 2017. Power of a Laugh “Your type of humor might say something about your risk of depression and anxiety.” by Eric W. Dolan. 2023. “Understanding the Association Between Humor and Emotional Distress: The Role of Light and Dark Humor in Predicting Depression, Anxiety, and Stress.” by Alberto Dionigi, et al. 2023. Caffeine & Soccer “Caffeine highs and lows footballers should be aware of.” n.a. 2023. “The effects of acute caffeine ingestion on decision-making and pass accuracy in young soccer players: A preliminary randomized controlled trial.” by Negar Jafari, et al. 2023. Follow Curiosity Daily on your favorite podcast app to get smarter with Calli and Nate — for free! Still curious? Get exclusive science shows, nature documentaries, and more real-life entertainment on discovery+! Go to https://discoveryplus.com/curiosity to start your 7-day free trial. discovery+ is currently only available for US subscribers. Hosted on Acast. See acast.com/privacy for more information.