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Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.09.25.313635v1?rss=1 Authors: Wani, A. H., Aiello, A. E., Kim, G. S., Xue, F., Martin, C. L., Ratanatharathorn, A., Qu, A., Koenen, K., Galea, S., Wildman, D. E., Uddin, M. Abstract: Background: A range of factors have been identified that contribute to greater incidence, severity, and prolonged course of post-traumatic stress disorder (PTSD), including: comorbid and/or prior psychopathology; social adversity such as low socioeconomic position, perceived discrimination, and isolation; and biological factors such as genomic variation at glucocorticoid receptor regulatory network (GRRN) genes. This complex etiology and clinical course make identification of people at higher risk of PTSD challenging. Here we leverage machine learning (ML) approaches to identify a core set of factors that may together predispose persons to PTSD. Methods: We used multiple ML approaches to assess the relationship among DNA methylation (DNAm) at GRRN genes, prior psychopathology, social adversity, and prospective risk for PTS severity (PTSS). Results: ML models predicted prospective risk of PTSS with high accuracy. The Gradient Boost approach was the top-performing model with mean absolute error of 0.135, mean square error of 0.047, root mean square error of 0.217, and R2 of 95.29%. Prior PTSS ranked highest in predicting the prospective risk of PTSS, accounting for >88% of the prediction. The top ranked GRRN CpG site was cg05616442, in AKT1, and the top ranked social adversity feature was loneliness. Conclusion: Multiple factors including prior PTSS, social adversity, and DNAm play a role in predicting prospective risk of PTSS. ML models identified factors accounting for increased PTSS risk with high accuracy, which may help to target risk factors that reduce the likelihood or course of PTSD, potentially pointing to approaches that can lead to early intervention. Copy rights belong to original authors. Visit the link for more info
Today I talk with Erik aka Grrn about his Ironsides crews. Donate to my new Patreon site here to gain access to unreleased episodes Walking Dream Studio can be found here if you are looking for commission painting. PNW Team Showdown on July 28th in Lakewood, WA can be found here The Nova Open on August 30th - Septemter 2nd in Washington, DC can be found here The English GT on September 8th-9th in Hockley, Essex can be found here The new US Masters Conferences can be found here Logfaux can be found here Schemes & Stones Discord server link (need software first) can be found here Schemes & Stones Blog site can be found here Schemes & Stones facebook group can be found here You can talk about this episode on the Wyrd forums here Please give us your feedback on twitter @SchemesNStones, leave us a review on itunes, or email us at Schemesandstones@gmail.com. Thanks for listening.
In this episode, Ben, Collins and Grrn break down the great mysteries of life, including Grail Quest, baseball, Warhammers, and your mom. But for reals, we talk about Grail Quest. And your mom.
Why I left the Gun Rights Radio Network Zombie Strike # 82 Barbara Baird at the Civil War Reenactment Michael J. Mullenhour author of "Arturus" Dry Firing New Shirt http://www.customink.com/signup/m6fdnw Kenn Blanchard
In this episode I may have waxed a little heavy on parenting and love but if your brother doesn't tell you who will. Love is the reason why we care. Don't forget to show it. Kenn provides a little fatherly and brotherly advice to men. Child safety How do you gun proof your home? How do you teach gun safety in your home? How do you introduce firearms to your family? Zombie Strike 42 Review part 2 of the ISSC Austria M22 pistol. This show is dedicated to parents, prospective parents and adults with children in their lives. www.blackmanwithagun.com has moved and changed into a blog. Barbara Baird provides a Gun Tip from Womens Outdoor News http://womensoutdoornews.com/ Tons of shout outs. Thank you for supporting this show. Please visit the new www.blackmanwithagun.us. Join me on facebook/kennblanchard
Once again we go into the vault for 2 segments too good to allow them to languish there any longer. First we visit with our brother from a different Mother; Kenn Blanchard, the GRRN. We met up with him at the last SHOT Show in Vegas and had a great time hanging out with him […] The post 056 The Urban Shooter and the Tactical Doctor appeared first on The ProArms Podcast.
Firepower Packed Show that is over an HOUR . Pro trainers Mas Ayoob, and Rob Pincus give their unique perspectives about Moving and Shooting Zombie Strike Chapter 8 part 2 Kenn sings Witchy Woman Jerome from California shares the woes of CALI make sure you consider joining the the Urban Shooter Association and visiting www.urbanshooterpodcast.com
Happy HalloweenHistory of the black catBad NewsMama Helen's picks for gun storageInterview with Rick Ector- DetroitImportance of Hearing ProtectionZombie Strike- Eric's RescueAnswer to episode 90's Shoot Don't Shoot- U DecideRecommendations on how to make money in the gun biz in 2009show length- 64 uncivilized minutesMachine Gun- Jimi Hendrixpodsafe music by Psykosoul
Shoot or Don't Shoot U Decide- Puts you in the awkward position of a law Abiding DC resident. Please send your comments to gunrightsradio.com Urban Shooter Forum for episode # 78 The crap you have to put up with to register a gun legally in DC. I tried to get a Browning High Power on Gunbroker.com, I lost the auction. Intro and outro voiceover: Debra Jean Dean http://www.debrajeandean.com You can check out the DC Gun Registration Form on my section of the Gun Rights Radio Forums. Intro music is from www.funkyguitar.com
I introduce a new feature called Shoot or Don’t Shoot where I hope provide some thought provoking discussion about what you would do if placed in this circumstance. I’d like to read your responses on the new Urban Shooter Forums (at the bottom of the forum list) on Gun Rights Radio. I talk about pendulum and Use of Force briefly. Part 3 of our racist roots of gun control segment ending in 1941. More to come. Introduction of new site and forum of five of the best pro-gun podcasters in the entire world. http://www.gunrightsradio.com/ and http://gunrightsradio.com/forums2/ Answer to the contest question from episode 71 is revealed by the Min. of Defense. There were no winners BTW. Thank you for your continued love and support.