Podcasts about Xue

As regulatory expectations evolve under the FDA's Project Optimus oncology dosing initiative, biostatistics is emerging as a central pillar in designing and executing trials that move beyond the traditional maximum tolerated dose (MTD) approach.In this fourth episode of our Project Optimus series, host Dr. Wael Harb is joined by biostatistics expert X.Q Xue, PhD, Vice President and Global Head, Biostatistics at Syneos Health to explore how statistical science is transforming dose optimization in oncology drug development. Dr. Xue discusses the limitations of legacy 3+3 dose-escalation designs and introduces innovative alternatives, including Bayesian modeling, adaptive trial strategies and randomized parallel dose-response studies, which support more precise dose selection and can ultimately improve patient outcomes and trial efficiency.Together, Drs. Harb and Xue examine how smaller biotech companies can overcome barriers to implementation, the role of simulation and AI in trial planning and how a biostatistics-driven approach may increase the likelihood of late-phase success, reduce post-marketing adjustments and support faster regulatory approvals.The views expressed in this podcast belong solely to the speakers and do not represent those of their organization. If you want access to more future-focused, actionable insights to help biopharmaceutical companies better execute and succeed in a constantly evolving environment, visit the Syneos Health Insights Hub. The perspectives you'll find there are driven by dynamic research and crafted by subject matter experts focused on real answers to help guide decision-making and investment. You can find it all at insightshub.health. Like what you're hearing? Be sure to rate and review us! We want to hear from you! If there's a topic you'd like us to cover on a future episode, contact us at podcast@syneoshealth.com.

Naszego wejścia w rok 2025, przynajmniej bełkotowo, nie można nazwać lekkim, łatwym i przyjemnym. Przyczyniła się do tego w dużym stopniu chińska pisarka Can Xue, a także jej polski wydawca – Państwowy Instytut Wydawniczy. To oni – przy współudziale tłumaczki Katarzyny Sarek – serwują nam lekturę, którą z pewnością można nazwać wymagającą. Na czym polegają trudności w odbiorze „Tajemniczego pociągu”? I czy warto się z nimi zmierzyć? O tym rozmawiamy w składzie Szymon Horała, Kasia Janusik i Waldek Mazur. Jest też między innymi o potencjalnym Noblu dla Xue, jej nietypowej metodzie pisarskiej i dzieciństwie, którego chyba nikt jej nie zazdrości. Realizacja odcinka: Piotr „Piciu” Pflegel.  Zapraszamy do słuchania!

Coming up on this episode of Flirtations, we have Yue Xu and Julie Krafchick, the dynamic duo behind the Dateable podcast and the new book, “How to Be Dateable,” to have a conversation with us about, well, dating! Julie and Yue will share with us today the 7 things that matter when looking for a partner and why connection and compatibility goes way beyond some chemistry and attraction. We'll learn about the key qualities to focus on when choosing someone for a relationship, how to avoid getting stuck in surface level connections, and what it really means to be dateable. Along the way, we'll touch on emotional availability, long-term compatibility, and how to create genuine, lasting connections so you can feel more confident and empowered in dating.  So, whether you're single, dating, or just curious about what makes relationships thrive, this episode is for you! It's for everyone, basically! Stay tuned! Don't forget to subscribe, rate, and review Flirtations on your favorite podcast platform, and share this episode to spread BFE - big flirt energy, all over the world! Enjoying the show and want to support my work? Buy the Flirt Coach a coffee! About our guests:  Julie Krafchick & Yue Xu are active daters turned dating insiders, and top influential voices of modern dating, relationships, and connection in the digital world. They're the authors of How To Be Dateable: The Essential Guide to Finding Your Person and Falling in Love and the co-hosts of the hit podcast Dateable, which has been named one of the top podcasts about modern dating and relationships by the New York Times, The Huffington Post, Oprah Daily, and more.  Connect with Julie and Xue on Instagram, Take the "Dating Archetype" Quiz, and grab your copy of How to Be Dateable! About your host:  Benjamin is a flirt and dating coach sharing his love of flirting and BFE - big flirt energy, with the world! A lifelong introvert and socially anxious member of society, Benjamin now helps singles and daters alike flirt with more confidence, clarity, and fun! As the flirt is all about connection, Benjamin helps the flirt community (the flirties!) date from a place that allows the value of connection in all forms - platonic and romantic connection - to take center stage and transform lives for greater healing and ultimately, a deeper connection with the self. You can connect with Benjamin on Instagram, TikTok, stream the Flirtations Flirtcast everywhere you listen to podcasts (like right here!), and find out more about working together 1:1 here.

Xue, Guisen, O. Felix Offodile, Rouzbeh Razavi, Dong-Heon Kwak, and Jose Benitez. "Addressing staffing challenges through improved planning: Demand-driven course schedule planning and instructor assignment in higher education." Decision Support Systems 187 (2024): 114345. This paper presents a novel decision support system (DSS) to address the University Course Timetabling Problem (UCTP). The solution decomposes the NP-complete UCTP into two sub-problems, allowing a structured approach to addressing the complexities inherent in the UCTP process. A mixed integer linear programming (MILP) model is proposed to integrate academic year course schedule planning and instructor assignment, accommodating various constraints to meet student demands. The model optimizes the number of course sections and strategically schedules instructors, aiming to reduce the number of new and distinct courses assigned to them. Historical data from an academic department encompassing multiple disciplines, including Computer Information Systems, Business Management, and Business Analytics, at a large public university in the U.S. is used to develop the model, and the results are compared with the actual course schedule and instructor assignment. The results demonstrate that the proposed DSS would result in a 14% reduction in the number of course sections offered, translating to approximately $130,000 in annual savings. Additionally, it could significantly reduce the number of new courses assigned to instructors by up to 81% and the number of distinct course sections assigned to them by 29%.

Happy New Year, 2025!This year is going to be incredible, and I'm starting it off strong! I had a relaxing New Year's Eve with my family and am proud to say I woke up hangover-free and ready to crush my goals.Over the past year, I made a major pivot in my life and business, all thanks to my amazing life and business coach, Xue Bravo. She has truly transformed the way I approach both my personal and professional life. Fun fact: I first met Xue when I photographed her for the cover of a magazine! She's a Christian mom of four (younger than me!) and an inspiration in every way.I've been diving headfirst into affiliate marketing, and the possibilities are endless. Huge shoutout to 17hats and Aftershoot for sponsoring this podcast and supporting my journey! Through affiliate digital marketing, I've discovered a path to passive income that has not only helped me but is also transforming the lives of wedding pros and creatives.Want to know how I'm making $1k a day, all from my phone, working just 1–2 hours a day? Watch my 9-minute video—it's a game-changer, and I know you can do it too! https://carissawoo.systeme.io/Hot Topic of the Day:“When You Prioritize Your Life, Your Business Grows Faster.”Today, we're unpacking this powerful concept and sharing actionable tips to help you strike the perfect balance between life and business.Tune in now for inspiration, practical advice, and some exciting updates about what's to come in 2025!Connect with Xue https://www.instagram.com/lifeandbusinesswithxuebravo/https://instagram.com/carissawoo

Financial forecasts are essential for every affordable housing developer to anticipate expenses, cash flow and access to capital to build or redevelop properties, including developments built using low-income housing tax credit (LIHTC) equity. In the latest installment of the Novogradac Tax Credit Tuesday podcast's recurring "So You Want to Be a LIHTC Developer" series, Michael Novogradac, CPA, and Miao Xue, CPA, delve into six ways that developers can enhance the benefits of financial forecasts. Novogradac and Xue introduce credit adjusters and twinning LIHTCs with renewable energy investment tax credits (ITCs) as well as digging deeper into four areas'development budget and eligible basis schedule, sources and uses and 15-year cash flow waterfall, the taxable income and loss schedule, and income and loss allocations and the Section 704(b) capital schedule'covered in a previous financial forecast-focused installment of "So You Want to Be a LIHTC Developer."

In this episode, you can listen to the Q&A after Vangeline's performance of the Slowest Wave in Singapore, organized by the butoh artist XUE and the Singapore Butoh Collective. During the Q&A, Xue, the audience, and Vangeline talk about topics such as the difficulty in describing Butoh, Butoh and neuroscience, The Slowest Wave, and the present and future of Butoh in Singapore. This episode was recorded on September 1st, 2024. Check them out: https://sgbutoh.co/ A couple of corrections: The first Butoh performance was Kinjiki, or Forbidden Ciolors, not Forbidden Flowers. Also, The two women neuroscientists who collaborated on the Slowest Wave, neuroscientists Sadye Paez and Constantina Theofanopoulou, dance flamenco, not tango. If you want to learn more about the Slowest Wave, read here: https://www.vangeline.com/research

Zang Fu, the Organ Systems of Traditional Chinese Medicine: Functions, Interrelationships and Patterns of Disharmony in Theory and Practice Author :Jeremy Ross Page 167-178 Part 3 Interrelationships Chapter14-1 Zang Fu Interrelationships Yin Yang Substances Qi, Xue and Jin Ye Jing and Shen Pathology of the Substances Shen Pi Gan Xin Fei Jing Luo Tissues Tissues Bones and Head Hair Muscles and Lips Tendons and Nails Xue Mai and Face Skin and Body Hair Orifice / Senses Shen and Ears Pi and Mouth Gan and Eyes Xin and Tongue Fei and Nose, Throat and Voice Curious Organs Marrow, Bones and Brain Uterus Xue Mai Dan

Victor Koo is a familiar face in China's tech industry. In the 90s, he was president of Sohu, China's second-largest search engine. Subsequently, he founded YouKu, China's largest online video platform with 500 million monthly users (commonly called the "YouTube of China" and later sold to Alibaba). Surprisingly, his journey of scaling began to turn inwards at a tech conference in Sun Valley in 2016, when a networking conversation with a young entrepreneur soon turned towards meditation. Upon hearing that Victor had always wanted to try it, the young entrepreneur let go of the opportunity to network with others, instead guiding Victor to an hour-long meditation. That was the first hour of meditation in Victor's life, a seed that he continues to cultivate through a daily practice now spanning several years. Along the way, on a trip to Thailand, he casually walked into a breathwork course without any context. That session, led by a teacher who had survived Stage-4 terminal cancer through breathwork practice, further opened up his inner world in a striking way. "If I never believed in chakras and energy body within each of us, that session blew all of that disbelief away based on direct experience that lasted over a day." As Victor's inner journey took root, it has also decidedly altered the course of his work in the world. After transitioning from his role at Youku, Victor shifted his focus to inner-purpose-driven service and investing. In late 2016, he co-founded Tianren Culture - a social platform based out of Hong Kong that aims to promote "One Wisdom, One Health" by encouraging and enabling contemplative practices and healthy lifestyles. It focuses especially on those practices and lifestyles with roots in spiritual and natural wisdom and non-dualistic philosophies, positing that human physical, mental, emotional, and spiritual health and wellness is interconnected with the health of the broader environment and ecosystem. Tianren Culture partners with foundations, NGOs, and businesses to put in place effective social innovation initiatives to improve physical wellness through overall food system transformation, as well as mental, emotional, and spiritual wellness by supporting scientific research and promoting meditation and breathwork practices. The Tianren team is actively volunteering time for Servicespace's AI-related initiatives, including CompassionGPT. Related to Tianren's work, Victor is also a board director of Good Food Fund and on the advisory board of Global Wellness Institute. Victor's exposure to multiple cultures has been formative in his journey - he was born in Hong Kong, and apart from twenty-five years in China, he has lived extensively in Australia, US, and Japan - with Japan being his current home since the pandemic. He received his BS degree from University of California, Berkeley, where he was also a Regent's scholar and MBA from Stanford Graduate School of Business, where he currently serves on the Advisory Council. Victor's professional experience lies mostly at the intersection of the technology and media sectors, as well as private equity and venture capital investments. He continues to serve as Chairman of Heyi (his company that incubated Youku), which now focuses on disruptive innovation and social impact investments in areas such as health, genome, and new protein. He is also a senior advisor of Texas Pacific Group and a business advisor of DeCheng Capital. "If there was one thing I wish I had known before I started my company, it is meditation (by far!) because of the calm and equanimity that it brings you, and really helps you question the purpose of why you're doing what you're doing." It's a piece of advice that Victor can often be found paying forward now to b-school students and young founders. Join us in conversation with this founder-turned-server, as we learn more about his journey of scaling inwards, or as he loves to quote Bruce Lee, to "be like water". The call will be hosted by Xue Devand and Birju Pandya. Xue formerly founded one of the "50 most innovative companies of the world" and now currently runs The Space Between, a venture capital fund aiming to be a "sacred hospitality" company that helps inspire wealthholders to transition their consciousness from being owners of money to being the stewards of money. Birju is Chief Mindfulness Officer/Managing Director at Mobius.life, an integrated capital family office, and a long-time volunteer with Servicespace.

Aujourd'hui, on parle du Trouble Obsessionnel Compulsif avec Margot Eisenblaetter, Psychologue Clinicienne au Service Universitaire de Psychiatrie Adulte (SUPA) au CHU de Montpellier. Margot est spécialisée dans la prise en charge du TOC.Doute pathologique, pensées inavouables, compulsions, phobies d'impulsion : viens nous écouter si tu veux tout comprendre de la logique du TOC. Que tu en souffre ou que tu sois aidant, cet épisode pourra t'aider !Belle écoute

Tuesday Talks with Xue Xia Freedom is your definition, plant that seed - What does it look like? Xue works with freedom lovers to get their time back and gain their lifestyle freedom while doing what they love. Xue is also an entrepreneur who runs three online businesses with her partner as they live and explore the world. Loves adventures, living in freedom, and growing with inspiring people. Sometimes she is weird af, unfiltered and inappropriate, but she is coming to terms with that

The Ministry of Public Security has debunked a video that sparked a nationwide search after it was widely circulated on social media.一段视频在社交媒体上引发了全国范围内的传播和关注，公安部对此视频进行了辟谣。The video, depicting homework booklets supposedly lost by a Chinese first grader in Paris, was revealed to be a meticulously crafted ploy for online attention.这个描述中国一年级小孩秦朗在巴黎丢作业的视频，是为了吸引网络关注而精心制作的。The ministry's expose was part of a broader effort to combat online rumors. On Friday, it presented details of 10 prominent cases, highlighting the Paris homework incident as a prime example.公安部的曝光是打击网络谣言的一部分。4月12日，公安部介绍了10个突出案例的细节，其中以“秦朗丢作业”为主要例子。The video was uploaded in February by a blogger surnamed Xu, from Zhejiang province. It showed a Parisian restaurant worker supposedly returning homework found in a restroom. The video said the homework belonged to Qin Lang from Class Eight, without specifying the school. That sparked a social media frenzy, with many netizens attempting to locate the child.这段视频是2024年2月由一位来自浙江的徐姓博主上传的。视频显示，一名巴黎餐厅工作人员正在归还在洗手间发现的作业。视频称，该作业属于八班的秦朗，但没有指明是哪所学校。这在社交媒体上引起了轩然大波，许多网友都试图找到这个孩子。However, the narrative quickly unraveled. A user claiming to be Qin Lang's uncle appeared in the comments section, providing an unverified school name. Subsequent investigations revealed the person making the comment, a person surnamed Yang from Jiangsu province, was another participant in the scheme to gain online attention and was not related to Xu.然而，故事很快就被揭穿了。一位自称是秦朗舅舅的用户出现在评论区，提供了一个未经证实的学校名称。随后的调查显示，发表这番言论的人是来自江苏省的杨某，他是该骗局的另一参与者，目的是吸引网上的关注，与徐某没有关系。Further investigation by authorities exposed the entire charade. Police discovered that Xu, along with her company director, surnamed Xue, scripted the video, purchased generic homework booklets online and staged the entire scene.公安的进一步调查揭露了整个骗局。警方发现，徐某和她的公司经理薛某一起编写了视频，在网上购买了通用的作业手册，并上演了整个场景。Facing administrative penalties and demands for public apologies, Xu admitted her initial lack of "legal awareness" but expressed remorse for the widespread attention and disruption caused by the video. Her social media accounts, boasting millions of followers across many platforms, have been suspended.徐某遭到行政处罚并被要求公开道歉。她承认她最初缺乏“法律意识”，并对该视频引起的广泛关注和混乱表示歉意。她在多个平台上拥有数百万粉丝的社交媒体账户已被封号。The incident underscores China's intensifying efforts to combat online misinformation.这一事件凸显了中国正在加大打击网络虚假信息的力度。In December, the ministry launched a nationwide campaign against online rumors. Over 80,000 leads and 10,000 cases have been investigated, with over 1,500 suspects apprehended and 10,700 individuals facing administrative penalties.2023年12月，公安部在全国范围内发起了一场打击网络谣言的运动。调查了8万多条线索和1万多起案件，逮捕了1500多名犯罪嫌疑人，对10700人进行了行政处罚。The ministry has vowed to continue its crackdown, targeting individuals who spread rumors, fabricate news or exploit trending topics for personal gain. Law enforcement authorities will increase inspections of major social media, livestreaming and short video platforms to identify and address malicious online activity.公安部表示将继续打击那些散布谣言、编造新闻或利用热门话题谋取私利的个人。执法部门将加强对主要社交媒体、直播和短视频平台的检查，以识别和解决恶意网络活动。Meticulously细致地；一丝不苟地Rumor谣传，流言

Good afternoon, I'm _____ with today's episode of EZ News. Tai-Ex opening The Tai-Ex opened up 13-points this morning from yesterday's close, at 20,213 on turnover of 4.5-billion N-T. The market staged a technical rebound on Wednesday as buying rotated to non-tech stocks. However, turnover was down from the previous trading days. Many investors remained wary of a major pullback after the main board scored solid gains in recent sessions to stand above the 20,000-point mark. Investors are also waiting for U-S economic data, which is due out later this week. First high-level Taiwan-France Trade Talks Focus on High-Tech The Ministry of Economics Affairs says representatives for Taiwan and France have held the first round of ministerial-level economic and trade talks. The talks focused on opportunities for collaboration (合作) in the high-tech supply chain. Taiwan's delegation was led by Economics Minister Wang Mei-hua, who met with representatives of France's Ministry of Economics and Finance. According to the economics ministry, the discussions covered possible partnerships in fields such as semiconductors, artificial intelligence, electric vehicles, renewable energy, and space industries. Carbon Fee Rate to be Decided in One to Two Months Environment Minister Xue Fu-sheng says it will take the government between one and two months to finalize the carbon fee rate. The Ministry of Environment was previously scheduled to announce the carbon fee rate in the first quarter of this year. The environment minister says the delay is because a review committee has not yet decided on the rate. However, Xue says there will be no change to the carbon fee collection schedule. The minister says the government still plans to collect (收) the fees beginning next year. WH: Talks with Israel on Gaza Operation Resume The White House says talks are resuming (恢復) to bring Israeli officials to the US to discuss Gaza operations. AP correspondent Ben Thomas reports. UN Food Waste Report A new United Nations report estimates that 19% of the food produced around the world went to waste in 2022. That's a little more than 1 billion metric tons of food. The updated Food Waste Index shows the biggest share of that waste, about 60%, came in households. Almost 30% came in food service operations, such as restaurants. This comes three years after the U.N.'s first attempt to quantify (量化) the problem as part of trying to cut food waste in half by the year 2030. That was the I.C.R.T. news, Check in again tomorrow for our simplified version of the news, uploaded every day in the afternoon. Enjoy the rest of your day, I'm _____. －－－－以下訊息由 SoundOn 動態廣告贊助商提供－－－－ 您是否聽過孩子抱怨：數學好無聊！數學好難！ 學數學真的只能是一直寫寫寫，不斷加減乘除嗎？ 提供孩子學習數學的新可能！《兒童數學動畫課》 把數學變得好玩、好看又好用！ 輸入 CW150 再享專屬折扣～ 馬上點擊下方連結吧！ https://cplink.co/e71OXAa6

China is launching a campaign targeting production safety accidents in coal mines following a newly enacted administrative regulation focused on the problem.中国正在开展一场针对煤矿生产安全事故的运动，此前刚刚颁布了一项针对这一问题的行政法规。The regulation was passed at the executive meeting of the State Council, China's Cabinet, last December and will be implemented in May.该条例于2023年12月在国务院常务会议上通过，将于2024年5月实施。Huang Jinsheng, head of the National Mine Safety Administration, said at a news conference held by the State Council Information Office on Sunday that coal mining, a traditionally high-risk industry, has always been a priority for production safety officials.2024年2月4日，国家矿山安全监察局局长黄锦生在国务院新闻办举行的新闻发布会上表示，煤矿作为传统的高危行业，一直是生产安全官员的首要关注点。He emphasized that as the nation seeks to further its socioeconomic development, there have been outstanding issues in coal mine production, such as the "inadequate implementation of safety production responsibilities, incomplete investigations, lax oversight of risks and hidden dangers, and an imperfect management system".他强调，随着国家寻求进一步的社会经济发展，煤矿生产中存在一些突出问题，如“安全生产责任制落实不到位、调查不全面、风险监管松懈、隐患多、管理制度不完善”等。The latest regulation was formulated against this backdrop, said Huang, noting that it's a foundational regulation in mining production safety, comprehensively summarizing the results of safety work in the field in recent years.黄锦生说，该条例就是在此背景下制定的。它是煤矿安全生产的基础性法规，全面总结了近年来该领域安全工作的成果。"The adoption of the regulation will help further implement the primary responsibility of coal mine enterprises in terms of safety production, and further strengthen supervision and monitoring responsibilities," he said.他说：“该条例的通过将有助于进一步落实煤矿企业在安全生产方面的主体责任，进一步加强监督和监测责任。” Production accidents in coal mines across the country have occurred frequently in recent times.近期，全国各地煤矿生产事故频发。In November, there was a major gas explosion at a coal mine in Heilongjiang province. The following month in Heilongjiang, there was an underground mine cart accident at another mine. The combined accidents resulted in 23 deaths and 13 injuries.11月，黑龙江省一煤矿发生重大瓦斯爆炸事故。12月，黑龙江另一煤矿发生井下矿车事故。两起事故共造成23人死亡，13人受伤。Also last month, another explosion happened at a coal mine in Henan province, causing 16 fatalities.就在上个月，河南省一煤矿又发生爆炸事故，造成16人死亡。According to the nation's chief mining production regulator, the regulation clearly stipulates that coal mine production should prioritize people's lives and property, adhering to the principle of "safety first".据国家煤矿生产监管部门负责人介绍，该条例明确规定，煤矿生产应当优先保障人民群众生命财产安全，坚持“安全第一”的原则。The regulation requires coal mine enterprises to regularly conduct safety inspections of their mines, marking the first time the relationship between coal mine enterprises and mines has been explicitly defined in administrative regulations.该条例要求煤矿企业定期对所属煤矿进行安全检查，这是行政法规中首次明确界定煤矿企业与煤矿之间的关系。The regulation also specifically demands that governments at the county level and above supervise and inspect coal mine enterprises, especially front-line production workplaces, said Huang, stressing that doing so increases the accountability of government officials.黄锦生说，该条例还特别要求县级以上政府监督和检查煤矿企业，特别是一线生产场所，这样做提高了政府官员的责任感。It's worth noting some local governments have allowed mines lacking safety guarantees to operate to ensure coal production and supply. Some grassroots governments "turn a blind eye" to illegal activities in coal mines within their jurisdictions, "even providing protection", according to another senior mining supervision official.值得注意的是，一些地方政府允许缺乏安全保障的矿山继续运营，以确保煤炭的生产和供应。另一位高级矿业监管官员表示，一些基层政府对辖区内煤矿的非法活动“视而不见”，“甚至提供保护”。Zhou Dechang, deputy head of the NMSA, underscored that safety must come first before ensuring coal production and supply.国家矿山安全监察局副局长周德昶强调，在确保煤炭生产和供应之前，安全必须放在首位。"They (local governments) cannot knowingly allow mines with significant safety risks to operate without shutting them down. Once a production safety accident occurs, ensuring coal mine production and supply is not an excuse to evade accident responsibility," he said.周德昶表示：“他们（地方政府）不能明知矿山存在重大安全隐患而允许其继续运营而不关闭。一旦发生生产安全事故，确保煤矿生产和供应并不是逃避事故责任的借口。”"Those who are directly responsible must be held accountable, and those suspected of illegal crimes should be transferred to judicial authorities for criminal prosecution."“对直接负责的人员必须追究责任，对涉嫌违法犯罪的人员应当移送司法机关追究刑事责任。”Some local coal mine enterprises prefer to pay the relatively low cost of the fines rather than comply with the law, production regulators said.生产监管部门表示，一些地方煤矿企业宁愿支付相对较低的罚款，也不愿遵守法律，。Xue Jianguang, director for policy and regulation at the NMSA, said penalties imposed by previous laws and regulations were too light.国家矿山安全监察局政策法规处处长薛剑光表示，此前法律法规规定的处罚过轻。To address this, the regulation further increases the cost of illegal activities for enterprises, including raising the minimum amount of fines, Xue said.薛剑光说，为了解决这一问题，该条例进一步增加了企业的违法成本，包括提高罚款的最低数额。"According to China's Production Safety Law, the minimum fines for enterprises involved in minor accidents is 300,000 yuan ($42,100); in relatively big accidents, 1 million yuan; and in major accidents 2 million yuan," he said. "The new regulation raises these minimum fines to 500,000 yuan for minor accidents, 1.5 million yuan for relatively big ones and 5 million yuan for major ones."“根据《中国安全生产法》，对发生一般事故的企业的最低罚款为30万元（4.21万美元）；发生较大事故的，罚款100万元；发生重大事故的，罚款200万元， 新条例将这些最低罚款提高到一般事故50万元，较大事故150万元，重大事故500万元。”Coal Mine Production Safety Accidents煤矿生产安全事故 Judicial Prosecution司法追究

China is launching a campaign targeting production safety accidents in coal mines following a newly enacted administrative regulation focused on the problem.中国正在开展一场针对煤矿生产安全事故的运动，此前刚刚颁布了一项针对这一问题的行政法规。The regulation was passed at the executive meeting of the State Council, China's Cabinet, last December and will be implemented in May.该条例于2023年12月在国务院常务会议上通过，将于2024年5月实施。Huang Jinsheng, head of the National Mine Safety Administration, said at a news conference held by the State Council Information Office on Sunday that coal mining, a traditionally high-risk industry, has always been a priority for production safety officials.2024年2月4日，国家矿山安全监察局局长黄锦生在国务院新闻办举行的新闻发布会上表示，煤矿作为传统的高危行业，一直是生产安全官员的首要关注点。He emphasized that as the nation seeks to further its socioeconomic development, there have been outstanding issues in coal mine production, such as the "inadequate implementation of safety production responsibilities, incomplete investigations, lax oversight of risks and hidden dangers, and an imperfect management system".他强调，随着国家寻求进一步的社会经济发展，煤矿生产中存在一些突出问题，如“安全生产责任制落实不到位、调查不全面、风险监管松懈、隐患多、管理制度不完善”等。The latest regulation was formulated against this backdrop, said Huang, noting that it's a foundational regulation in mining production safety, comprehensively summarizing the results of safety work in the field in recent years.黄锦生说，该条例就是在此背景下制定的。它是煤矿安全生产的基础性法规，全面总结了近年来该领域安全工作的成果。"The adoption of the regulation will help further implement the primary responsibility of coal mine enterprises in terms of safety production, and further strengthen supervision and monitoring responsibilities," he said.他说：“该条例的通过将有助于进一步落实煤矿企业在安全生产方面的主体责任，进一步加强监督和监测责任。” Production accidents in coal mines across the country have occurred frequently in recent times.近期，全国各地煤矿生产事故频发。In November, there was a major gas explosion at a coal mine in Heilongjiang province. The following month in Heilongjiang, there was an underground mine cart accident at another mine. The combined accidents resulted in 23 deaths and 13 injuries.11月，黑龙江省一煤矿发生重大瓦斯爆炸事故。12月，黑龙江另一煤矿发生井下矿车事故。两起事故共造成23人死亡，13人受伤。Also last month, another explosion happened at a coal mine in Henan province, causing 16 fatalities.就在上个月，河南省一煤矿又发生爆炸事故，造成16人死亡。According to the nation's chief mining production regulator, the regulation clearly stipulates that coal mine production should prioritize people's lives and property, adhering to the principle of "safety first".据国家煤矿生产监管部门负责人介绍，该条例明确规定，煤矿生产应当优先保障人民群众生命财产安全，坚持“安全第一”的原则。The regulation requires coal mine enterprises to regularly conduct safety inspections of their mines, marking the first time the relationship between coal mine enterprises and mines has been explicitly defined in administrative regulations.该条例要求煤矿企业定期对所属煤矿进行安全检查，这是行政法规中首次明确界定煤矿企业与煤矿之间的关系。The regulation also specifically demands that governments at the county level and above supervise and inspect coal mine enterprises, especially front-line production workplaces, said Huang, stressing that doing so increases the accountability of government officials.黄锦生说，该条例还特别要求县级以上政府监督和检查煤矿企业，特别是一线生产场所，这样做提高了政府官员的责任感。It's worth noting some local governments have allowed mines lacking safety guarantees to operate to ensure coal production and supply. Some grassroots governments "turn a blind eye" to illegal activities in coal mines within their jurisdictions, "even providing protection", according to another senior mining supervision official.值得注意的是，一些地方政府允许缺乏安全保障的矿山继续运营，以确保煤炭的生产和供应。另一位高级矿业监管官员表示，一些基层政府对辖区内煤矿的非法活动“视而不见”，“甚至提供保护”。Zhou Dechang, deputy head of the NMSA, underscored that safety must come first before ensuring coal production and supply.国家矿山安全监察局副局长周德昶强调，在确保煤炭生产和供应之前，安全必须放在首位。"They (local governments) cannot knowingly allow mines with significant safety risks to operate without shutting them down. Once a production safety accident occurs, ensuring coal mine production and supply is not an excuse to evade accident responsibility," he said.周德昶表示：“他们（地方政府）不能明知矿山存在重大安全隐患而允许其继续运营而不关闭。一旦发生生产安全事故，确保煤矿生产和供应并不是逃避事故责任的借口。”"Those who are directly responsible must be held accountable, and those suspected of illegal crimes should be transferred to judicial authorities for criminal prosecution."“对直接负责的人员必须追究责任，对涉嫌违法犯罪的人员应当移送司法机关追究刑事责任。”Some local coal mine enterprises prefer to pay the relatively low cost of the fines rather than comply with the law, production regulators said.生产监管部门表示，一些地方煤矿企业宁愿支付相对较低的罚款，也不愿遵守法律，。Xue Jianguang, director for policy and regulation at the NMSA, said penalties imposed by previous laws and regulations were too light.国家矿山安全监察局政策法规处处长薛剑光表示，此前法律法规规定的处罚过轻。To address this, the regulation further increases the cost of illegal activities for enterprises, including raising the minimum amount of fines, Xue said.薛剑光说，为了解决这一问题，该条例进一步增加了企业的违法成本，包括提高罚款的最低数额。"According to China's Production Safety Law, the minimum fines for enterprises involved in minor accidents is 300,000 yuan ($42,100); in relatively big accidents, 1 million yuan; and in major accidents 2 million yuan," he said. "The new regulation raises these minimum fines to 500,000 yuan for minor accidents, 1.5 million yuan for relatively big ones and 5 million yuan for major ones."“根据《中国安全生产法》，对发生一般事故的企业的最低罚款为30万元（4.21万美元）；发生较大事故的，罚款100万元；发生重大事故的，罚款200万元， 新条例将这些最低罚款提高到一般事故50万元，较大事故150万元，重大事故500万元。”Coal Mine Production Safety Accidents煤矿生产安全事故 Judicial Prosecution司法追究

Good afternoon, I'm _____ with today's episode of EZ News. Tai-Ex opening The Tai-Ex opened marginally down this morning from yesterday's close, at 17,356 on turnover of 1.6-billion N-T. The market retreated from an early rise to end the day slightly higher on Wednesday - as Taiwan Semiconductor Manufacturing saw its gains eroded ( 削弱) ahead of the release of its November sales data. Investor sentiment also turned cautious ahead of the release of U-S nonfarm payroll data tomorrow, as many are waiting for more guidance on the Federal Reserve's monetary policy. Environment Minister in Dubai for COP28 Environment Minister Xue Fu-sheng is in Dubai for the COP28 meeting. According to Ministry of Environment, Xue is leading a delegation of other government officials to the two-week United Nations's annual climate change conference. Taiwan hasn't been formally invited to attend the conference, but officials are attending peripheral (週邊) meetings and holding talks on the sidelines of the event. The environment minister says he's been highlighting Taiwan's plans to reach climate goals and showcasing the government's resolution to pursue efforts to limit the average global temperature rise during those meetings in Dubai. Pufferfish that Killed 1 and Hospitalized 8 Others was "Inedible" And, The Food and Drug Administration says a poisonous pufferfish that was served by a restaurant owner in Nantou County last month has been identified as an lunartail puffer. The meal left one person dead and resulted in eight other people being hospitalized. According to the F-D-A, samples of the fish were sent for testing immediately following the man's death and D-N-A samples identified it as a lunartail puffer - which is an inedible (不可食用的) variety of the fish. The F-D-A says the lunartail puffer can be easily confused with species in the same genus that are edible when properly prepared. The sale, processing and producing of food stuffs made with pufferfish are illegal under the Act Governing Food Safety and Sanitation. US Ukraine Funding Stalls in Senate US President Joe Biden's push to pass tens of billions of dollars in new aid for Ukraine has stalled in the Senate. Republican lawmakers blocked the funding - which also includes help for Israel - in a protest over a dispute (爭議) about border security policy. Kate Fisher reports from Washington France Charges for Man Who Killed Tourist Near Eiffel Tower Prosecutors say a man accused of fatally stabbing a tourist and injuring two other people over the weekend near the Eiffel Tower has been placed under investigation on charges of murder and attempted murder in connection with a terrorist organization. The suspect went before an investigating magistrate Wednesday who ultimately decides preliminary charges. The stabbing over the weekend killed a German-Filipino tourist at a bridge near the tower. It has drawn special concern from French authorities less than a year before the 2024 Paris Olympics, whose opening ceremony is planned along the Seine river. The man had been under surveillance for suspected Islamic radicalization. Mexico Supreme Court Overturns Bullfighting Ban Mexico's Supreme Court has overturned (推翻) a 2022 ban on bullfighting in Mexico City, opening the way for events to resume, possibly as soon as this month. A panel of justices voted to overturn a May 2022 injunction that said bull fights violated city resident's rights to a healthy environment free from violence. The panel did not explain their arguments for overturning the ban, but fight organizers claimed it violated their right to continue the tradition. The capital had a history of almost 500 years of bullfighting, but there had been no fights since the 2022 injunction. That was the I.C.R.T. news, Check in again tomorrow for our simplified version of the news, uploaded every day in the afternoon. Enjoy the rest of your day, I'm _____.

What's the next step to grow your business? Entrepreneurs often reach a standstill when launching new ideas, but connecting with a welcoming, safe community can help your creative juices flow. Today's guests—Will, Mariana, Sara, Xue, Randi, and myself—all attended the same live event. We entered with varying intentions and left with similar takeaways. The people we met and the concepts we learned were nothing short of amazing. And we don't want to keep these lessons secret any longer! Here's how connecting with a safe, like-minded community will give you the clarity needed to take your business to the next level. Special Thanks to Eileen and Harrison Wilder and Jackie Lacroix for this incredible event !! Stay connected with today's inspirational guests: Will: Visit cashflowautomationworkshop.com to get in touch. Mariana: @brandmagnetic on Instagram and host of the Empire Secrets podcast Sara: @therealsaramoses on Instagram and host of the Do It Now podcast Xue: @xuebravo_ on Instagram and host of Making A Million podcast Randi: Follow Do The Thing Formula everywhere to see what's going behind the scenes.

As interações ecológicas são uma das principais forças que sustentam a biodiversidade da Terra. Um desafio para os estudos de ecologia e evolução é determinar como essas interações afetam a evolução entre pares ou redes de espécies. Separe trinta minutinhos do seu dia e descubra, com a Mila Massuda, como ocorrem os processos coevolutivos ou como as espécies, ao longo da história da Terra, dançam em uma interminável substituição de adaptações que criam laços complexos. Apresentação: Mila Massuda (@milamassuda) Roteiro: Mila Massuda (@milamassuda) e Emilio Garcia (@emilioblablalogia) Edição: @Matheus_Heredia (@mewmediaLAB) Produção: Prof. Vítor Soares (@profvitorsoares) e BláBláLogia (@blablalogia) REFERÊNCIAS: BENKMAN, Craig W.; HOLIMON, William C.; SMITH, Julie W. The influence of a competitor on the geographic mosaic of coevolution between crossbills and lodgepole pine. Evolution, v. 55, n. 2, p. 282-294, 2001. BENSON, Woodruff W.; BROWN JR, Keith S.; GILBERT, Lawrence E. Coevolution of plants and herbivores: passion flower butterflies. Evolution, p. 659-680, 1975. EHRLICH, Paul R.; RAVEN, Peter H. Butterflies and plants: a study in coevolution. Evolution, p. 586-608, 1964. MASSUDA, Kamila F.; TRIGO, R. Chemical defence of the warningly coloured caterpillars of Methona themisto (Lepidoptera: Nymphalidae: Ithomiinae). European Journal of Entomology, v. 106, n. 2, p. 253, 2009. MASSUDA, Kamila Ferreira. Multimodalidade de defesas em Ipomoea carnea subsp. fistulosa (Convolvulaceae) e em seus herbívoros, os besouros Cassidinae (Chrysomelidae). 2015. Tese de Doutorado. PAUW, Anton. Floral syndromes accurately predict pollination by a specialized oil‐collecting bee (Rediviva peringueyi, Melittidae) in a guild of South African orchids (Coryciinae). American Journal of Botany, v. 93, n. 6, p. 917-926, 2006. SASANI, Thomas A. et al. Large, three-generation human families reveal post-zygotic mosaicism and variability in germline mutation accumulation. Elife, v. 8, p. e46922, 2019. XUE, Yali et al. Human Y chromosome base-substitution mutation rate measured by direct sequencing in a deep-rooting pedigree. Current Biology, v. 19, n. 17, p. 1453-1457, 2009.

S1 Ep8: What do you do when you have big goals and desires for your life but your partner is stuck in the nine-to-five corporate mindset? Xue called The Life Coach Hotline wondering how she can move forward with her dream life, despite her partner not sharing the same vision.   Click here for full show notes, transcript, and more information: https://lindseymangocoaching.com/s1e8   If you want to call in to The Life Coach Hotline, go to lindseymango coaching.com/lifecoachhotline.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.03.547302v1?rss=1 Authors: Qiu, S., Cao, H., Xue, Y., Zhao, W., Xie, S., Wu, N., Song, M., Pan, Y.-H., Baas, P. W., Ma, J., Yuan, X.-B. Abstract: Katanin catalytic subunit A1 like 2 (KATNAL2) is a high-risk gene associated with autism spectrum disorders (ASD), however its impact on brain development and disease remains unclear. The present study revealed an unexpected role of KATNAL2 in regulating ependymal ciliary motion and cerebrospinal fluid flow during brain development, an important contributing factor for ASD. We discovered a distinct expression pattern of KATNAL2 in multiciliated ependymal cells of both human and mouse brains. Notably, an ASD-associated mutation of Katnal2 disrupted its molecular function and resulted in ASD-related behavioral deficits in mice. Additionally, this mutation affected the polarized organization and beating of ependymal cilia, leading to delayed cerebrospinal fluid flow and sustained ventricular enlargement from the early postnatal stage. Conditional ablation of Katnal2 specifically in the ependymal cells of neonatal mice is sufficient to cause ventricular dilation, whereas no such effect was observed in adult mice. Our findings highlight the importance of ependymal motile cilia and hydrocephalus in ASD, offering insights into its pathogenesis and potential intervention. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

On this episode of The Yegi Project we speak to Xue, a freedom & time management coach. After realizing that her corporate job was giving her anxiety and negatively impacting her work/life balance, she and her boyfriend - now husband - decided to quit their jobs without a back-up plan. Even when things didn't go according to plan post quitting, she still found a way to push through the obstacles and successfully start multiple businesses all while having the freedom to travel whenever and wherever she wants. She now works with others to help them optimize their time and gain back their personal freedom as well.Follow Xue! https://www.instagram.com/xueunscripted/ https://stan.store/xueunscripted Follow The Yegi Project on Instagram! https://www.instagram.com/theyegiprojectMore About Your Host:Yegi is a young entrepreneur who has always been curious and hardworking. You can say she has always seen things out of the box and been able to creatively solve difficult problems. Her cool and collective spirit in life and business makes you want to be around her. She thrives on inspiring others and helps others see things from a positive point of view. The Yegi Project, is the podcast for the young entrepreneur who may not know where to start, doesn't have anyone to guide them in the right direction and may not have full support from others. This podcast is called The Yegi “Project” because although Yegi is happy with where she is now, she knows that she still has a lot to do to complete her mission and purpose in this world. She aims to use this podcast to work hard alongside all of you to grow to a point where she can make a lasting change in people's lives and in the world.  If you would like to be a guest on a future episode of The Yegi Project, please email info@yegiproject.comThe Yegi Project is available on Apple Podcasts, Spotify, Stitcher and more!https://linktr.ee/theyegiprojectDisclaimer: This podcast or any other The Yegi Project episodes on this platform or other podcast streaming platforms is not legal business or tax advice. I make this content based on my own experience as a business owner and MBA for educational and entertainment purposes only.

El día de hoy te traigo una entrevista super especial que tuve con Xue Neisa, una gran amiga y persona super especial en mi vida, con ella he aprendido mucho no solo sobre productividad, sino también mucho sobre amor propio, es más que una amiga, es una mentora y guía en mi vida. Y hoy nos habla sobre 4 aspectos claves que todos debemos trabajar para la consecución de nuestras metas. Instagram de XUE https://www.instagram.com/xueneisa/ Recuerda que puedes escribir por mi Instagram www.anngiavila.com/anngiavila o a mi correo podcastdiariodeunaemprendedora@gmail.com Recuerda que puedes comentar en mis redes sociales: ✒︎ ¿NOS SEGUIMOS EN REDES SOCIALES? ⬇ ✅ Twitter: https://twitter.com/AnngiAvila ✅ Facebook: https://www.facebook.com/AnngiAvila/ ✅ Instagram: https://www.instagram.com/anngiavila/ ✅ Pinterest: https://www.pinterest.com/anngiavila24/ --- Send in a voice message: https://podcasters.spotify.com/pod/show/anngiavila/message

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.04.10.536251v1?rss=1 Authors: Kuruppath, P., Xue, L., Pouille, F., Jones, S. T., Schoppa, N. Abstract: Fragile X syndrome (FXS) is the single most common monogenetic cause of autism spectrum disorders in humans. FXS is caused by loss of expression of the Fragile X mental retardation protein (FMRP), an mRNA-binding protein encoded on the X chromosome involved in suppressing protein translation. Sensory processing deficits have been a major focus of studies of FXS in both humans and rodent models of FXS, but olfactory deficits remain poorly understood. Here we conducted experiments in wild-type and Fmr1 KO (Fmr1-/y) mice (males) that lack expression of the gene encoding FMRP to assess olfactory circuit and behavioral abnormalities. In patch-clamp recordings conducted in slices of the olfactory bulb, output mitral cells (MCs) in Fmr1 KO mice displayed greatly enhanced excitation, as evidenced by a much higher rate of occurrence of spontaneous network-level events known as long-lasting depolarizations (LLDs). The higher probability of LLDs did not appear to reflect changes in inhibitory connections onto MCs but rather enhanced spontaneous excitation of external tufted cells (eTCs) that provide feedforward excitation onto MCs within glomeruli. In addition, in a go/no-go operant discrimination paradigm, we found that Fmr1 KO mice displayed impaired discrimination of odors in difficult tasks that involved odor mixtures but not altered discrimination of monomolecular odors. We suggest that the higher excitability of MCs in Fmr1 KO mice may impair fine odor discrimination by broadening odor tuning curves of MCs and/or altering synchronized oscillations through changes in transient inhibition. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Reduced Lead Setting for Diagnostic ECG Interpretation Using Deep Learning Models Guests: Joel Xue, Ph.D. Hosts: Anthony H. Kashou, M.D. (@anthonykashoumd) Joining us today to discuss what reduced-lead ECG analysis is, it's clinical value, some of its challenges, and how it compares to standard 12-lead ECG analysis is Joel Xue, Ph.D. Dr. Xue currently leads the AI group of AliveCor and is an adjunct professor of Bioinformatics department at Emory University, Atlanta, Georgia. Tune in to learn about using Deep learning models to reduce lead setting for diagnostic ECG interpretation. Specific topics discussed: What is reduced-12-lead ECG, and what is its clinical value? What are the main challenges for the reduced lead ECG analysis? How the Deep learning model method can be applied to reduced lead ECG analysis? Are the analysis performance comparable to the standard 12-lead ECG analysis? Next steps R&D and clinical use. Connect with Mayo Clinic's Cardiovascular Continuing Medical Education online at https://cveducation.mayo.edu or on Twitter @MayoClinicCV and @MayoCVservices. Facebook: MayoCVservices LinkedIn: Mayo Clinic Cardiovascular Services NEW Cardiovascular Education App: The Mayo Clinic Cardiovascular CME App is an innovative educational platform that features cardiology-focused continuing medical education wherever and whenever you need it. Use this app to access other free content and browse upcoming courses. Download it for free in Apple or Google stores today! No CME credit offered for this episode. Podcast episode transcript found here.

EPISODE SUMMARY In this episode of Chan with a Plan, Max Speaks with Xue Hua, software engineer in tech and Chief Tech Officer at Boba Talks. During this conversation Xue discusses her journey to getting her job in tech, overcoming obstacles, and preparing for tech company interviews. QUOTES FROM XUE “You'll feel like you're doing everything right, but you're still not landing an offer. It really depends on your learning style. Programming is an iterative process, so they just gave me the project. I didn't have to ask. I wasn't expecting it, and it was a big decision.” “It really depends on your learning style. I've had people learn from books. I've had people learn from Udemy videos. I've had people learn from practicing it.” “They saw that on my resume I had that freelance thing and that really set me apart from the other candidates because they had a problem with their current website or their current management system, and they needed somebody who understood how to make websites or applications. So that really helped me stand apart.”   TIMESTAMPS [01:12] Xue's educational background [04:39] Difficulties in learning multiple coding languages [07:38] Resources for learning to code [09:56] Using internships and co-ops to help your career path [11:22] Preparing for first interviews [13:28] Gaining additional experience through projects in your job [16:20] Learning lessons when overcoming job search obstacles [19:07] Lacking the experience needed [20:35] Improving interview skills [24:45] Pivoting in your career [28:48] Tips for getting into top tech companies [33:37] Balancing offers while you wait for others [36:42] Culture shock [41:59] One big career challenge Xue had to overcame   RESOURCES & RELEVANT LINKS Xue Hua on Social Media:LinkedIn Chan With A Plan Max Chan on Social Media

Good afternoon, I'm _____ with today's episode of EZ News. **Tai-Ex opening ** The Tai-Ex opened down 31-points this morning from yesterday's close, at 14,678 on turnover of 2.9-billion N-T. The market gained ground on Tuesday in a volatile (易變的) trading session, as investors were closely watching the situation in China. The market fluctuated by almost 300 points during the trading day. Semiconductor stocks led an initial downturn, but the local main board made a sharp rebound after investors opted to use temporary declines in the share prices to increase their holdings. **NHI Copayment Plan Could be Delayed ** Health Minister Xue Rui-yuan says plans to implement (實施) an increase in National Health Insurance copayments could be delayed depending on how the island's economy performs in the coming months. The plan is currently slated to be introduced sometime in the first quarter of next year. However, the health minister says an exact timeframe has not yet been decided, as the domestic coronavirus situation and how fast the island's economy can recover from the pandemic could affect the finalizing of an implementation date. Xue says his office will be making further assessments of the overall situation in the coming weeks. **Central Bank Head Cits Weak NT$ as Contributing to Inflation ** Central Bank Governor Yang Jin-long says the New Taiwan dollar will likely depreciate by around 6-per cent against the U-S dollar this year, driving up the price of imports and adding up to 0.3 percentage points to the consumer price index. According to Yang several factors have contributed to (成為因素) rising inflation in Taiwan over the last two years. They include coronavirus-era supply chain bottlenecks, the impact of the Russia-Ukraine war on food and energy prices, and Taiwan's vulnerability as a small economy to price fluctuations on international markets. While the other major factor is imported inflation, which has been driven up by both the rising costs of imported materials and products and by the depreciation of the New Taiwan dollar. **US Senate Passes SameSex Marriage Bill ** The U.S. Senate has passed a landmark (地標性的) bill protecting same-sex and interracial marriage across the country - and it did it with the support of both Democrats and Republicans. Toni Waterman has more. **Finland Calls for Weapons for Ukraine in NZ and Australia ** Finland's leader says it must give more weapons and support to Ukraine to ensure it wins its war against Russia. Prime Minister Sanna Marin made the comments today in Auckland as she embarked on the first-ever visit by a Finnish leader to New Zealand and Australia. Among the aims of the visit are improving diplomatic relations and trade ties. Since the war began, both Finland and Sweden have abandoned their longstanding policies of military nonalignment and applied to join NATO. That was the I.C.R.T. news, Check in again tomorrow for our simplified version of the news, uploaded every day in the afternoon. Enjoy the rest of your day, I'm _____.

Do you often find yourself comparing yourself to other people in your life? Or that you need to compete with others to get more love and attention?  We all feel that way at some - or many - points in our lives, and it can negatively affect our energy and sense of worthiness. So how can we cope with these feelings effectively? In this episode, Coach Ajit coaches Xue Xia, who struggles with these negative thought spirals even when she's at her best in life and career. If you resonate with Xue or have clients in a similar situation, listen in on this conversation for powerful practices and ideas you can start implementing immediately.   Key Insights: Understanding why we compare ourselves with others and how it affects our lives. The importance of managing one's energy. How to avoid negative downward spirals.  The key to building meaningful relationships with friends. We are nurturing our sense of worthiness and self-love. How to identify triggers and set practices to cope with them. The role of routines and how it impacts our energy daily.   Connect with us! IG: @realcoachajit IG: @evercoach FB: Evercoach by Mindvalley Website: www.evercoach.com Thank you so much for checking out this episode of Master Coaching with Ajit. If you enjoyed this episode, please leave us a rating and review on your favorite podcast app, and don't forget to subscribe to enjoy every new episode every single week.

This month on Episode 39 of Discover CircRes, host Cynthia St. Hilaire highlights four original research articles featured in the August 5th and 19th issues of the journal. This episode also features an interview with Dr Annet Kirabo and Dr Ashley Pitzer from Vanderbilt University on their article, Dendritic Cell ENaC-Dependent Inflammasome Activation Contributes to Salt-Sensitive Hypertension.   Article highlights:   Jain, et al. Role of UPR in Platelets   Orlich et al: SRF Function in Mural Cells of the CNS   Xue et al: Gut Microbial IPA Inhibits Atherosclerosis   Wang et al: Endothelial ETS1 on Heart Development   Cindy St. Hilaire:        Hi, welcome to Discover CircRes, the podcast of the American Heart Association's journal Circulation Research. I'm your host, Dr Cindy St. Hilaire from the Vascular Medicine Institute at the University of Pittsburgh, and today I'm going to be highlighting articles from our August 5th and August 19th issues of Circulation Research. I'm also going to have a chat with Dr Annet Kirabo and Dr Ashley Pitzer from Vanderbilt University about their study, Dendritic Cell ENaC-Dependent Inflammasome Activation Contributes to Salt-Sensitive Hypertension.   But before I get to the interview, I first want to share an article from our August 5th issue, and that article is titled, Unfolded Protein Response Differentially Modulates the Platelet Phenotype. The first author of this study is Kanika Jain and the corresponding author is John Hwa from Yale University. Self-stress can lead to protein misfolding, and the accumulation of misfolded proteins can lead to a reduction in protein translation and may alter gene transcription, a process collectively known as the unfolded protein response, or UPR. UPR is well documented in nucleated cells; however, it has not been studied in platelets, which are anuclear, but do have a rapid response to cellular stress. In this study, they investigated the UPR in anucleate platelets and explore its role, if any, in platelet physiology and function.   They found that treating human and mouse platelets with various stressors caused aggregations of misfolded proteins and induction of UPR-specific factors. Oxidative stress, for example, induced the UPR kinase PERK, while an endoplasmic reticulum stressor induced the transcription of the UPR factor XBP1. The team went on to study the UPR in platelets from people with type II diabetes, which is a population in which platelet mediated thrombosis is a major complication. They showed that protein aggregation and upregulation of the XBP1 pathway in diabetic patient platelets correlated with disease severity. Furthermore, treating the diabetic patient platelets with a chemical chaperone that helps to correct protein misfolding reduced protein aggregations and prevented the cells prothrombotic activation. This work confirms that even without transcription, platelets display stress-induced UPR, and that targeting this response may be a way to reduce thrombotic risk in diabetic patients.   Cindy St. Hilaire:        The second article I want to share with you is from our August 5th issue and is titled, Mural Cell SRF Controls Pericyte Migration, Vessel Patterning and Blood Flow, and it was led by Michael Orlich from Uppsala University in Sweden. Blood vessels are lined with endothelial cells and surrounded by mural cells. Vascular smooth muscle cells are the mural cells in the case of veins and arteries, and pericytes are the mural cells in the case of capillaries. In the capillaries, pericytes maintain blood-brain and blood-retina barrier function and can mediate vascular tone, similar to smooth muscle cells. While these pericytes and smooth muscle cells are related, they have distinct roles and characteristics.   To learn more about the similarities and the differences between pericytes and smooth muscle cells, this group examined how each would be affected by the absence of SRF in the other. SRF is a transcription factor, essential for nonvascular or visceral smooth muscle cell function. In visceral smooth muscle cells, SRF drives expression of smooth muscle actin and other smooth muscle genes. Using mice engineered to lack SRF in mural cells, they show that SRF drives smooth muscle gene expression in these pericytes and smooth muscle cells, and its loss from smooth muscle cells causes atrial venous malformations and diminishes vascular tone. In pericytes, loss of SRF impaired cell migration in angiogenic sprouting. In a mouse model of retinopathy, activation of SRF drove pathological growth of pericytes. This work not only highlights the various functions of SRF in mural cell biology, but it also suggests that it has a role in pathological capillary patterning.   Cindy St. Hilaire:        The third article I want to share is from our August 19th issue of Circulation Research and is titled, Gut Microbially Produced Indole-3-Propionic Acid Inhibits Atherosclerosis by Promoting Reverse Cholesterol Transport and its Deficiency Is Causally Related to Atherosclerotic Cardiovascular Disease. The first authors are Hongliang Xue and Xu Chen, and the corresponding author is Wenhua Ling from Sun Yat-Sen University in Guangzhou, China. Recent studies provide evidence that disorders in the gut microbiota and gut microbiome derived metabolites affect the development of atherosclerosis. However, which and how specific gut microbial metabolites contribute to the progression of atherosclerosis and the clinical relevance of these alterations remain unclear. Gut microbiome derived metabolites, such as short-chain fatty acids and trimethylamine N-oxide, or TMAO, have been found to correlate with atherosclerotic disease severity.   This study has now found that serum levels of indole-3-propionic acid, or IPA, are lower in atherosclerosis patients than controls. The team performed unbiased metagenomic and metabolomic analyses on fecal and serum samples from 30 coronary artery disease patients and found that, compared with controls, patients with atherosclerosis had lower gut bacterial diversity, depletion of species that commonly produce IPA and lower levels of IPA in their blood. Examination of a second larger cohort of atherosclerosis patients confirmed this IPA disease correlation. The team also showed serum IPA was reduced in a mouse model of atherosclerosis, and that supplementing such mice with dietary IPA could slow disease progression. Analysis of the macrophages from these mice showed that IPA increased cholesterol efflux, and the team went on to elucidate the molecular steps involved. The results of this study not only unraveled the details of IPA's influence on atherosclerosis, but suggest boosting levels of this metabolite could slow atherosclerotic disease progression.   Cindy St. Hilaire:        The last article I want to share is also from our August 19th issue, and it's titled, Endothelial Loss of ETS1 Impairs Coronary Vascular Development and Leads to Ventricular Non-Compaction. The first author is Lu Wang and the corresponding author is Paul Grossfeld, and they are at UCSD. Congenital heart defects, or CHDs, are present in nearly 1% of the human population. In some cases, the heart defects result from a genetic error, which can give researchers clues to its etiology. Jacobson syndrome is a complex condition caused by deletions from one end of chromosome 11, and the occurrence of a congenital heart defect in this syndrome has been associated with the loss of the gene ETS1. ETS1 is an angiogenesis promoting transcription factor, but how ETS1 functions in heart development was not known.   Wang and colleagues now show that both global or endothelial-specific loss of ETS1 in mice caused differences in embryonic heart development that ultimately led to a muscular wall defect known as ventricular non-compaction. The mice also had defective coronary vasculogenesis associated with decreased abundance of endothelial cells in the ventricular myocardium. RNA sequencing of ventricular tissue revealed that, compared with controls, mice lacking ETS1 had reduced expression of several important angiogenesis genes and upregulation of extracellular matrix factors, which together contributed to the muscular and vascular defects.   Cindy St. Hilaire:        Today I have with me, Dr Annet Kirabo and Dr Ashley Pitzer, both from Vanderbilt University, and we're going to talk about their paper, Dendritic Cell ENaC-Dependent Inflammasome Activation Contributes to Salt-Sensitive Hypertension. This article is in our August 5th issue of Circulation Research. Thank you both so much for joining me today.   Annet Kirabo:             Yeah, thank you so much for having us.   Ashley Pitzer:              Yeah, thank you for having us.   Cindy St. Hilaire:        Yeah, it's a great paper. I think we're all familiar with hypertension and this idea that too much salt is bad for our cardiovascular system. When I was a kid, my grandparents had those salt replacements on their kitchen table, Mrs. Dash and whatever. But, like you said in the start of your paper, the exact mechanism by which salt intake increases blood pressure and also increases cardiovascular risk, it's not really well understood, and you guys are focusing on the contribution of immune responses in this process or in this pathogenesis. Before we dig into the details of your paper, I was wondering if you could give us a little bit of background about what's known regarding the role of inflammation in this salt-sensitive hypertension pathogenesis.   Annet Kirabo:             Yeah. It's difficult to know where begin to from, but the role of inflammation in cardiovascular disease have been known for many, many decades. Right now, Dr David Harrison showed more than 10 years ago that T cells contribute to hypertension, but the mechanisms were not known. Back when I was a post doc in David Harrison's lab, we discovered a new mechanism, how immune cells are activated in inflammation and hypertension, whereby we found that there is increased oxidative stress in antigen-presenting cells. This leads to formation of oxidative products known as arachidonic acid or lipid products known as isolevuglandin, or IsoLGs. These IsoLGs are highly, highly reactive and they adapt to lysines on proteins. This is a covalent binding, which leads to permanent alteration of proteins, and so these proteins act as neoantigens that are presented as self-antigens to T cells, leading to an autoimmune-like state in hypertension.   Annet Kirabo:             We found that these antigen-presenting cells are activated and they start producing a lot of cytokines that paralyze T cells to IL-17 producing T cells that contribute to hypertension. And so, when I started my lab back in 2016, we discovered that excess dietary salt profoundly activates this pathway, and we found for the first time that these antigen-presenting cells, they express ENaC, the epithelial sodium channel, and sodium goes into these antigen-presenting cells and activates the NADPH oxidase, which is an enzyme which produces this reactive oxygen species, leading to this IsoLG formation, which I've talked about, and leading to inflammation.   So, three years ago when Ashley joined my lab, she had extensively studied the inflammasome in her PhD program, and she suggested why don't we look at the role of the inflammasome in this pathway and how IsoLG may contribute to this. In her paper that we are discussing right now, she found that in a dependent manner, sodium enters the cell and activates this pathway, and the NLRP3 inflammasome is involved in this process.   Cindy St. Hilaire:        That's such a wonderful story that fits together so many pieces. One of the things you talk about, which I guess I didn't even appreciate myself is, there are certain individuals out there who are more salt-sensitive than others.   Annet Kirabo:             Yeah.   Cindy St. Hilaire:        What is that difference? Do we know the root cause of that? And then also, how many individuals are we talking about are salt-sensitive?   Annet Kirabo:             Salt-sensitive blood pressure, it is a variable trait and it's normally distributed in the population, but it happens more in some individuals than others. It happens even in 25% of people without any hypertension. These people go to that doctor, that doctor thinks they're normal, they don't have any hypertension, but these people can be at a risk of sudden heart attack or cardiovascular risk or even a stroke, simply because when they eat a salty meal, their blood pressure will go up.   Cindy St. Hilaire:        Yeah, that's one of my questions. How much salt are we talking about here? And not only how much in a meal, but a sustained amount? How bad is a miso soup a day?   Annet Kirabo:             Yes. The American Heart Association and the World Health Organization have recommendations. American Heart Association recommends one spoon per day. We have refused to adapt to this recommendation, but that is the recommendation that they have recommended per day to eat. But this is difficult because most of the salt, as you know, is already in our food through processing in our processed foods and we don't have any control over how much salt we have, and there's also a lot of adding of salt at a table.   Cindy St. Hilaire:        Ashley, your background was more the inflammasome. What were your thoughts entering into this project? Did you have much of a hypertension background?   Ashley Pitzer:              No. My graduate thesis focused mainly on endothelial dysfunction and cardiovascular disease, and so it was a pretty easy segue. But it was just with Annet, so excited about the project and showing me all the data and this robust IL-1 beta production that she was seeing after these immune cells being exposed to high salt, I, with my inflammasome background, was immediately like, this could be playing a role. And so it was, like I said, a pretty easy transition and, as is in the paper, we're doing human studies. All of my research back in grad school was very basic research, so it was very exciting to see how our research was being translated with people having this condition and potentially finding mechanisms where we can target this to help actual people.   Cindy St. Hilaire:        I think a lot of us who are not in the hypertension field, and maybe this was you before you joined Annet's lab, we really only kind of think of the kidneys and the blood vessels when we think about hypertension, but studies like this are changing that. And I think a lot of Annet's earlier work, as well as the work of others, have shown a role for this epithelial sodium channel as an important player in this salt-induced hypertension. New to me, it's not just found in the kidney, which I totally did not appreciate that. And it's this channel sensing the salt that can trigger this IL-1 beta production that does a whole bunch of other things.   Cindy St. Hilaire:        What are those other things? What are those cells that are affected and where is this happening? Obviously it's not just kidney cells, but is it only in the kidney or are these systemic cells? What do we think is happening?   Ashley Pitzer:              That's the question, is, where is this happening? There's been studies at Vanderbilt by Jens Titze and his lab showing, where are these immune cells sensing the salt? And so they've shown that sodium accumulates in the skin, a huge argument is for they're sensing the sodium in the kidney because that's where a lot of it is being processed. But these immune cells travel through the whole body, so they're seeing it where there are the highest amounts of sodium concentration, and so I would argue it's in the kidney.   Annet Kirabo:             Indeed, because we're now collaborating with Tina Kon, and we have recently published with her a paper in the International Journal of Science, where we have done sodium MRI and we find this accumulation of sodium in the kidney even much more than in the skin. And we know that the kidney is where sodium is highly concentrated. So the working hypothesis in the lab is that these immune cells can be activated wherever they are, in the lymph nodes or not, in other tissues, but they can travel to the kidney.   We find that in high salt, if you feed high salt to the mouse, the endothelium in the kidney becomes dysfunctional and it expresses molecules, chemoattractants, that attract these immune cells in the kidney. We think that the high salt accumulation in the kidney can activate these, and then these immune cells are activated and they produce cytokines. Dr Steve Crowley showed that they can produce IL-1 beta, which induces activation of sodium channels that can be induced. We have also actually found that even IL-17 can be produced by these immune cells in the kidney and they can activate sodium channels in the kidney, leading retention of sodium and water and hypertension.   Cindy St. Hilaire:        Very cool. You used a lot of mice in this paper. Can you tell us, I just want to know a little bit about the models you chose to use, but also how similar is hypertension in mouse and humans? Obviously for atherosclerosis, we have to do lots of things to get them to form a plaque. Is hypertension similar in a mouse and do mice also show this salt-sensitive phenotype?   Annet Kirabo:             That is an extremely important point. If you read our paper, we use a slightly different approach. Most people do benchside to bed approach. We did the opposite. We did a bed to benchside approach.   Cindy St. Hilaire:        Always smart.   Annet Kirabo:             Yeah. We first started humans, and then with some references, we went to the mice, because I think when it comes to salt-sensitive blood pressure, mice are different from humans. In fact, if we look in the lab, we find that female mice are protected from salt-sensitive blood pressure, but we find that in the humans, it's the opposite. Females are more prone to salt-sensitive hypertension. Those are studies that we are doing right now. We haven't published. But we know that it can be different.   The model we use most of the time in the lab, the C57 mice, are resistant to salt-sensitive hypertension. These C57 mice would rather die before they raise their blood pressure in response to salt. We can induce salt-sensitivity in these mice like in the paper that we are discussing. When we induce the endothelial dysfunction using L-NAME and we wash it out, then these mice, when you give them, subsequently, salt, suggests that they become salt-sensitive. But we also have a salt-sensitive mouse model that we use, the 129/SV mouse. So we use several models to kind of prove the same thing over and over again with the findings that we found in humans.   Cindy St. Hilaire:        And you used a technique, which I'm a little bit familiar with, but I'd like to hear, A, about it from you, but also your experience in using it, and that is CITE-seq. So, how does that work?   Ashley Pitzer:              That was with our human study where we actually had patients come in, who were hypertensive, took them off medication for 2 weeks. They come in, we get baseline samples, we give them a salt load on one day, and then the next day we completely salt deplete them.   Cindy St. Hilaire:        How much is a salt load? Like a Big Mac? What's a salt load?   Ashley Pitzer:              Yeah, it's pretty much just like eating Lays chips all day. It's a lot of salt. It's a very salty meal.   Annet Kirabo:             And then in addition, we also infuse saline too.   Cindy St. Hilaire:        Oh, wow.   Annet Kirabo:             Because these people, when they come into the hospital, some them have already eating high salt. This approach is to just maximize the whole system so that then when we sort deplete everybody, it's at the same level and it's just to unify the whole process. But sorry, Ashley, you go ahead.   Ashley Pitzer:              With the CITE-seq, we're able to take different patients on different days. So we take samples each day, and we can give each sample a barcode, basically. Give them a barcode, we can pool them all together, process them, and we can sequence their RNA, we can probe for a certain amount of protein expression as well. So then when we analyze, we can look at protein expression, so you get the translation and the transcription for each person on each day, and then you're able to compare. And so you get this huge picture and it's a lot of data.   Cindy St. Hilaire:        How long did it take you to sort through?   Ashley Pitzer:              Well, we have a statistician who does all of that, because my wheelhouse is here and it is on a different planet. So we have somebody who helps us with that who does an unbiased approach. And then once he does an analysis, gives us back what are the things that are changing the most, and one of those was IL-1 beta.   Annet Kirabo:             As you can see, our list is huge, this is a massive input of so many collaborators. We have computational people on there that help us with this. I can't even begin to learn these techniques, but with all this collaboration and the resources at Vanderbilt, these things are possible. And so, this is a really powerful approach where you can combine protein expression and you get the specific cells that express the genes and you couple the channel type to the gene expression.   Annet Kirabo:             We actually found that not all monocytes are the same. There's a specific class that of monocytes, A small class of monocytes that is so angry, and the inflammasome is activated and producing this IL-1 beta, and that is enough to contribute to this phenotype of salt-sensitive hypertension, which dynamically changed according to blood pressure, suggesting that this is a targetable salt-sensitive blood pressure, even in normotensive people, is a targetable trait. And because these monocytes are in blood, can we get a blood sample and routinely diagnose salt-sensitive blood pressure so that doctors are aware and they can appropriately advise patients.   Cindy St. Hilaire:        This was samples obviously taken from a blood draw, right? So they're circulating.   Annet Kirabo:             It was a blood draw, yes.   Cindy St. Hilaire:        What do you think about these immune cells, perhaps, native in the kidney? Do you think the small population of angry cells, like you said, is escaping from the kidney environment? What do you think?   Annet Kirabo:             When I was a post-doc in David Harrison's lab, we found that the most angry dendritic cells that contribute to this inflammation and hypertension are monocyte-derived. So that's why in the human study we focused on monocytes, because there are so many subtypes of dendritic cells, plasmacytoid dendritic, classical dendritic cells. We have studied all of these subtypes, and we have focused on monocyte-derived dendritic cells because they're the ones that seem to be contributing to this phenotype the most.                                     Cindy St. Hilaire:        You guys focused in on the NLRP3 inflammasome, which, obviously it's a really critical component broadly for the innate immune system. Do you think that this is going to be a targetable approach that can be leveraged for hypertension? Or do you think it's too broad? What do you think about that as a therapeutic potential?   Ashley Pitzer:              Even when you look in our paper, and we use a knockout model, where we use a completely global knockout model, put them on high salt, and we give them back only dendritic cells that are from wild-type mice, so they have that NLRP3, that have been exposed to high salt. We were able to increase blood pressure, but I also did, in mice, where I gave them an IL-1 beta neutralizing antibody, similar to canakinumab, which is the CANTOS trial, and there's not much of a difference. There is, but it's minor. It's very minor.   Ashley Pitzer:              So, to be able to target in specific cell types in humans one thing, it's very difficult, and maybe one day we can get there. But I think it at least gives us a better idea of what is the full picture, what's the big mechanism going on with immune cells? In part of our human study, we are looking at something to try and be able to identify who is salt sensitive. So if anything, we're able to sit here and potentially have a way of identifying salt-sensitive patients, where, right now, all we can do is have them come in like we do and do a 3-day study, and not everybody can do that.   Annet Kirabo:             To add onto that, perhaps you know, we are talking about precision medicine. This is an era of precision medicine where you need to really tailor treatments if we can get there, and I think this is one way. CANTOS trial. They had no way of knowing who is salt-sensitive and who is not, it was a global approach, and the lack of differences in blood pressure might be explained that this IL-1 beta pathway is targetable in a specific population whose blood pressure is probably driven by inflammation. There are so many, many mechanisms that drive hypertension, and so perhaps we need to focus this on salt-sensitive people, and maybe we can really use this approach to target. Plus, this is ENaC-dependent.   As you know, amiloride has lost favor in the clinic as a treatment of hypertension, because in the majority, it's not effective. But studies have shown that in Black men, for example, who had been categorized salt-resistant, when they give them amiloride, their blood pressure went down, and yet it's not effective in the majority of the people.   So, can we bring back, can we take another look at amiloride. As our studies indicate that blockade of ENaC is anti-inflammatory and it's also antioxidant agent, can we at least bring back amiloride and look at it again and we focus it for specific populations of people that may be more prone to salt-sensitive hypertension?   Here we have so many targets for potential precision treatment of salt-sensitive potential in this paper. You can target SGK1, which we know is possible, we listed a number of clinical trials that they have used NLRP3 inflammasome inhibitors, you can use amiloride for these people, and you can also potentially scavenge IsoLGs.     Cindy St. Hilaire:        What was the most challenging aspect of this study? There's a lot of moving parts, so what was the biggest challenge? And then, also, what was the most surprising part or the most pleasantly surprising part?   Ashley Pitzer:              You have to think, most of this was going on right when the pandemic hit. And right before that, we had started our human recruitment for the human study. And so that put a little bit of a time damper on it.   Ashley Pitzer:              Other than that, it was just, we were finding one thing, developing a new experiment, doing it again, doing it again. And honestly, what was the most surprising and rewarding was just seeing the same thing in, because we took just PBMCs from normotensive patients, treated them with high salt, and saw the changes that we did with the inflammasome. And to see that exactly again in an in vivo model of giving patients high salt and seeing the same thing, it was very rewarding and confirmed that, okay, we're on the right path. Seeing the same thing over and over and over again, it kind of reaffirms that you had a good idea.   Annet Kirabo:             I might add, one of the most challenging was, initially, the computational. Oh, part of the pandemic I was, the pandemic hit, I had a baby during the pandemic, and it was my time to leave my home, and then all these things were going on. We had a clinical trial where patients had to come in. Vanderbilt was so super supportive ,even checking for COVID-19. Our patients could not have COVID-19. We needed to check them.   Cindy St. Hilaire:        Yeah.   Annet Kirabo:             They also had to check for COVID-19. And so during that time, I realized, wait, I need learn computation analysis. I realized I cannot learn, and then reached out to collaborators that helped. That was extremely challenging. And then the other challenging thing that we faced later during the pandemic is vaccinations. In our criteria, these people cannot be vaccinated for reasons. We've studied inflammation, hypertension, and so vaccination was confounding. And even COVID-19 is even more for confounding. So we had this exclusion criteria where we could not recruit anyone.   Annet Kirabo:             Everybody was having COVID, everybody was being vaccinated, and everybody was in that exclusion criteria, so it was difficult to get people. We have had some slow down, but right now it's beginning to build up.   Cindy St. Hilaire:        So, what's next? What's the next question?   Annet Kirabo:             We have so many.   Cindy St. Hilaire:        That means it was a great study. If you have more, that means it was a great study.   Annet Kirabo:             Yeah. This study and us, it kind of warms. The inside seat just opened up, we have primary data in the genetic regulation of ENaC, we have primary data where we found. We are trying to figure out the specific ENaC channel in these antigen-presenting cells. We don't know. We found that ENaC delta, for example, it's not found in a kidney or you talked about a kidney contribution versus immune cells. ENaC delta is not found in the kidney, but we have primary data that show that ENaC delta is the most correlated with cardiovascular risk, is the most correlated with kidney disease and all forms of hypertension. So now we're like, ENaC delta expressed in the immune cells, not in the kidney, it is the one that is most involved in cardiovascular disease, so how are we going to tell the world that.   Cindy St. Hilaire:        Yeah, very cool.   Annet Kirabo:             Those cells, not necessarily the kidney. The kidney plays a part because the cells are going there, but it's very, very exciting. Plus a number of other lines that we are investigating.   Cindy St. Hilaire:        It's great. Well, congratulations, again, on this publication, on just getting all this done with what sounds like extremely difficult patient recruitment. So, Dr Kirabo and Dr Pitzer, thank you so much for joining me today and I'm looking forward to these next studies on maybe ENaC delta.   Annet Kirabo:             Thank you. Thank you so much.   Ashley Pitzer:              Thank you for having us.   Cindy St. Hilaire:        That's it for the highlights from the August 5th and August 19th issues of Circulation Research. Thank you for listening. Please check out the CircRes Facebook page and follow us on Twitter and Instagram with the handle @CircRes and hashtag Discover CircRes. Thank you to our guests, Dr Annet Kirabo and Dr Ashley Pitzer.   This podcast is produced by Ashara Ratnayaka, edited by Melissa Stoner, and supported by the editorial team of Circulation Research. Some of the copy text for the highlighted articles is provided by Ruth Williams. I'm your host, Dr Cindy St. Hilaire, and this is Discover CircRes, your on the go source for the most exciting discoveries in basic cardiovascular research. This program is copyright of the American Heart Association 2022. Opinions expressed by speakers in this podcast are their own, and not necessarily those of the editors or of the American Heart Association. For more information, visit ahajournals.org.  

China's Special Envoy for the Horn of Africa, Xue Bing, wrapped up a two-day peace conference in Addis Ababa last week, Beijing's first-ever effort to mediate conflicts outside of Asia. Xue personally offered to serve as a broker to help resolve many of the ongoing tensions that currently roil the region.Superficially, all of the participants responded favorably to China's efforts but the real test will come in the months ahead to see if Beijing can match its promises with tangible results.Aly Verjee, a non-resident senior advisor at the United States Institute of Peace, is a leading expert in the politics of the Horn of Africa. He joins Cobus to share his impressions of China's performance at the conference and whether he thinks Beijing has what it takes to help mediate the region's various conflicts.JOIN THE DISCUSSION:Twitter: @ChinaGSProject| @stadenesque | @alyverjeeFacebook: www.facebook.com/ChinaAfricaProjectFOLLOW CAP IN FRENCH AND ARABIC:Français: www.projetafriquechine.com | @AfrikChineعربي: www.akhbaralsin-africia.com | @AkhbarAlSinAfrJOIN US ON PATREON!Become a CAP Patreon member and get all sorts of cool stuff including our Week in Review report, an invitation to join monthly Zoom calls with Eric & Cobus, and even an awesome new CAP Podcast mug!www.patreon.com/chinaafricaprojectSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

ShadowTalk host Stefano alongside Xue, and Kim bring you the latest in threat intelligence. This week they cover: - LockBit x Mandiant PR stunt - Bohrium targets victims in various geographies Get this week's intelligence summary at: https://resources.digitalshadows.com/weekly-intelligence-summary/weekly-intelligence-summary-10-jun/ ***Resources from this week's podcast*** Killnet: The Hactivist Group That Started A Global Cyber War: https://www.digitalshadows.com/blog-and-research/killnet-the-hactivist-group-that-started-a-global-cyber-war/ -Ransomware Gangs and PR Stunts: Why LockBit Faked a Ransomware Attack Against Mandiant https://www.digitalshadows.com/blog-and-research/ransomware-gangs-and-pr-stunts-why-lockbit-faked-a-ransomware-attack-against-mandiant/

ShadowTalk host Stefano alongside Xue, Kim, & Rory bring you the latest in threat intelligence. This week they cover: * Cybercrime group Lapsus$ is back * Cyber activity in the Russia-Ukraine war so far ***Resources from this week's podcast*** The Russia – Ukraine War: Two Months In https://www.digitalshadows.com/blog-and-research/the-russia-ukraine-war-two-months-in/ Opportunity In The Midst Of Chaos: Russian-Speaking Cybercriminals Grapple With Sanctions And Forum Takedowns https://www.digitalshadows.com/blog-and-research/russian-speaking-cybercriminals-grapple-with-sanctions-and-forum-takedowns/ Leaked Chats Show LAPSUS$ Stole T-Mobile Source Code https://krebsonsecurity.com/2022/04/leaked-chats-show-lapsus-stole-t-mobile-source-code/ Subscribe to our threat intelligence email: https://info.digitalshadows.com/SubscribetoEmail-Podcast_Reg.html Also, don't forget to reach out to - shadowtalk@digitalshadows.com - if you have any questions, comments, or suggestions for the next episodes.

I am an Integrative Fertility Expert with a background in Chinese medicine so obviously, I talk about it quite a bit.  It is not the mainstream medical system in the United States, and there are lots of skepticism around it.  Is it real?  Is it woo-woo or is there evidence supporting its effectiveness?  Those are the big questions that you are probably wondering about before embracing this system that is a few thousand years old to help you get pregnant.  Today, I am going to present some of the evidence behind Chinese medicine and you can decide if it's legit or if it's too new agey for you. To follow me on Instagram, TikTok, and Facebook: @dradriennewei Reference: Feng, J., Wang, J., Zhang, Y., Zhang, Y., Jia, L., Zhang, D., Zhang, J., Han, Y., & Luo, S. (2021). The efficacy of complementary and alternative medicine in the treatment of female infertility. Evidence-based Complementary and Alternative Medicine : eCAM, 2021, 6634309. https://doi.org/10.1155/2021/6634309 Johansson, J., & Stener-Victorin, E. (2013). Polycystic ovary syndrome: effect and mechanisms of acupuncture for ovulation induction. Evidence-based Complementary and Alternative Medicine : eCAM, 2013, 762615. https://doi.org/10.1155/2013/762615 Liu, H., Xu, J. Y., Li, L., Shan, B. C., Nie, B. B., & Xue, J. Q. (2013). FMRI evidence of acupoints specificity in two adjacent acupoints. Evidence-based complementary and alternative medicine : eCAM, 2013, 932581. https://doi.org/10.1155/2013/932581 Liu, L., Liu, Y., Yang, M., Xu, G., Li, R., Xu, X., Pan, X., & Liang, J. (2020). Effectiveness of tonifying-kidney and regulating-liver therapy on diminished ovarian reserve: a systematic review and Meta-analysis of randomized controlled trials. Journal of Traditional Chinese Medicine = Chung i tsa chih ying wen pan, 40(3), 343–354. https://doi.org/10.19852/j.cnki.jtcm.2020.03.001 Maciocia, G. (2015). The foundations of Chinese medicine. Elsevier. Ried, K. (2015). Chinese herbal medicine for female infertility: an updated meta-analysis. Complementary Therapies in Medicine, 23(1), 116-128. https://doi.org/10.1016/j.ctim.2014.12.004 Zhang, C., & Xu, X. (2016). Advancement in the treatment of diminished ovarian reserve by traditional Chinese and Western medicine. Experimental and Therapeutic Medicine, 11(4), 1173–1176. https://doi.org/10.3892/etm.2016.3025

ShadowTalk host Stefano alongside Kim, Xue, and Rick bring you the latest in threat intelligence. This week they cover a recap of a highly dynamic quarter including: * Log4j complex mitigation and remediation * REvil arrests * Cybercrime and Russia-Ukraine War * Extortion and the emergence of Lapsus$ ***Resources from this week's podcast*** Log4j: What's Happened Since https://www.digitalshadows.com/blog-and-research/log4j-whats-happened-since/ The Log4j Zero-Day: What We Know So Far https://www.digitalshadows.com/blog-and-research/the-log4j-zero-day-what-we-know-so-far/ Meet Lapsus$: An Unusual Group In The Cyber Extortion Business https://www.digitalshadows.com/blog-and-research/meet-lapsus-an-unusual-group-in-the-cyber-extortion-business/ How Cybercriminals Are Using Messaging Platforms https://www.digitalshadows.com/blog-and-research/how-cybercriminals-are-using-messaging-platforms/ Ransomware Q4 Overview https://www.digitalshadows.com/blog-and-research/ransomware-q4-overview/ Subscribe to our threat intelligence email: https://info.digitalshadows.com/SubscribetoEmail-Podcast_Reg.html Also, don't forget to reach out to - shadowtalk@digitalshadows.com - if you have any questions, comments, or suggestions for the next episodes.

ShadowTalk host Stefano alongside Kim and Xue bring you the latest in threat intelligence. This week they cover: * Conti Leaks * Reactions from Cybercriminals * Priority Intelligence Requirements ***Resources from this week's podcast*** Russian Cyber Threats: Practical Advice For Security Leaders https://www.digitalshadows.com/blog-and-research/russian-cyber-threats-practical-advice-for-security-leaders/ Cybercriminals React To Ukraine-Russia Conflict https://www.digitalshadows.com/blog-and-research/cybercriminals-react-to-ukraine-russia-conflict/ Intelligence Requirements: Planning Your Cyber Response To The Russia-Ukraine War https://www.digitalshadows.com/blog-and-research/planning-your-cyber-response-to-the-russia-ukraine-war/ Conti Ransomware Group Diaries, Part I: Evasion https://krebsonsecurity.com/2022/03/conti-ransomware-group-diaries-part-i-evasion/ Subscribe to our threat intelligence email: https://info.digitalshadows.com/SubscribetoEmail-Podcast_Reg.html Also, don't forget to reach out to - shadowtalk@digitalshadows.com - if you have any questions, comments, or suggestions for the next episodes.

The first woman partner at a major international law firm in Tokyo is my guest in the finale of Season Two of Lawyer on Air. Not only is she a Partner but she is about to take her second maternity leave, so this is an episode not to be missed for anyone considering taking leave to spend more time with their family or considering a sabbatical and wondering how it might affect your career. If you enjoyed this episode and it inspired you in some way, we'd love to hear about it and know your biggest takeaway. Head over to Apple Podcasts to leave a review and we'd love it if you would leave us a message here! In this episode you'll hear: How Xue overcame the challenge of doing a law degree in her third language Navigating being accepted for a trainee role in a top “Magic Circle” firm How Xue secured a secondment to a company in Japan Helping to create the maternity leave policy at her law firm and how a coach helped her to reframe the time out from her career How Xue is navigating taking a second maternity leave, this time as a Partner The danger of self imposed glass ceilings for women in their legal careers Her favourite book and other fun facts About Xue Xue is a Partner in Allen & Overy's Tokyo office, one of the leading international law firms globally, and specializes in the development and financing of energy and infrastructure projects, and on energy transition projects and initiatives. Xue's clients include leading international energy companies, financial institutions and government or multilateral agencies involved in these projects across the world, and she regularly works on a wide range of energy and infrastructure projects in Africa, the Middle East, Europe APAC and LatAm. Xue's practice also covers Japan and China, and prior to the pandemic she also used to spend a significant amount of time in China on a fly in fly out basis. Xue was born in China, but spent most of her formative years in Germany before moving to the UK for university. Since university, she has also lived in Paris, London, Brussels, Hong Kong and spent about 6 months travelling the world before starting her legal career. She joined A&O as a trainee in London in 2017 and has been with A&O ever since. In 2011, she had the opportunity to come to Japan for a client secondment with Mitsui bussan, where she spent 18 months on secondment, working as part of the infrastructure business unit. She rejoined A&O's Tokyo office in 2013 and has been building her practice and career here ever since, and was promoted as the first female partner in the Tokyo office in 2020. Xue is a mother of one (about to be two) and lives in Tokyo with her husband. She's passionate about promoting diversity and inclusion in the legal profession and would love to see more women and diversity in leadership positions. In her spare time, she likes to cook, snowboard, cycle, run and travel the world. Connect with Xue LinkedIn Links Mama Luisa's Restaurant: http://www.luisa-table.com/ How to avoid a climate change disaster by Bill Gates Connect with Catherine Linked In https://www.linkedin.com/in/oconnellcatherine/ Instagram: https://www.instagram.com/lawyeronair

The Grey is inherently divided into two parts: the mist and the grey maze. The mist is formed with combinations of clinging consciousness, or consciousness combinations in short, attached to one by physical matter, some of which are also known as genetic Xue-Jing consciousness combinations. Because of the genetic Xue-Jing consciousness combinations, one already has his own thinking traits inherited from his biological parents and ancestors before formation of his body. These durably-linked consciousness combinations have strong influences on one. Specifically, one might see ancestors' images, or communicate with them, or even mimic their sound frequencies.Written by Nhi TranEditted and narrated by Dung MaiImage by Huy NguyenDonate for us:

In this episode of the Mom Owned and Operated podcast, Rita Suzanne talks to Xue Bravo all about how she is raising a family, running a business and remembering herself. Xue is a wife, stay at home mom to four, multi business owner, social media and business strategist for new and aspiring mom entrepreneurs. She is on a mission to empower more moms to pursue their passions of owning a business and being the wonderful mama that they are. She does this by teaching them how to start, build and grow their business using simplified social media strategies. Grab the free Growth Guide from Xue to get you from 0-1k followers in less than 90 days! Listen to more interviews by visiting momownedandoperated.com and apply to work with Rita at ritasuzanne.com/apply/

本期我们关注的话题是中国最重要的市场化的气候变化政策——全国碳市场。从十二五规划开始碳排放权交易试点开始，中国的碳市场经过十年稳步推进，今年全国发电行业的碳交易市场有望正式上线。这期话题我们就聊聊碳税、碳市场政策的理论基础、在中国和世界的发展，以及碳税和碳市场到底作用几何。本期是这个话题的下半部分。【本期内容】第三部分：碳价格政策在世界的发展01:20 世界碳价格政策综述04:27 墨西哥和哈萨克斯坦这些发展中国家很早采用了碳价格政策07:00 世界范围内的碳价格和部门覆盖10:50 世界上的碳价格政策真的可以减排吗？18:30 碳价格政策会导致空气污染不平等减排吗？第四部分：碳价格政策可以帮我们实现碳中和吗23:30 “市场失灵”足以概括气候变化问题吗？28:26 政治、社会、技术、政策在气候变化应对的作用31:40 气候变化应对的紧迫性 ：行政手段vs.市场手段35:00 碳市场交易政策是“冗余”还是“兜底”？ 37:26 碳价格政策不能解决其他的市场失灵问题？41:25 碳价格政策与创新问题参考文献：“World Bank. 2020. State and Trends of Carbon Pricing 2020. Washington, DC: World Bank. © World Bank. https://openknowledge.worldbank.org/handle/10986/33809 License: CC BY 3.0 IGO.”Rafaty, R., Dolphin, G., & Pretis, F. (2020). Carbon pricing and the elasticity of CO2 emissions.Vance, E. (2012). Mexico passes climate-change law. Nature News.Green, J. F. (2021). Does carbon pricing reduce emissions? A review of ex-post analyses. Environmental Research Letters.Hernandez-Cortes, D., & Meng, K. C. (2020). Do environmental markets cause environmental injustice? evidence from california's carbon market (No. w27205). National Bureau of Economic Research.Rosenbloom, D., Markard, J., Geels, F. W., & Fuenfschilling, L. (2020). Opinion: Why carbon pricing is not sufficient to mitigate climate change—and how “sustainability transition policy” can help. Proceedings of the National Academy of Sciences, 117(16), 8664-8668.Azevedo, I., Davidson, M. R., Jenkins, J. D., Karplus, V. J., & Victor, D. G. (2020). The paths to Net Zero: How technology can save the planet. Foreign Aff., 99, 18.Zhu, J., Fan, Y., Deng, X., & Xue, L. (2019). Low-carbon innovation induced by emissions trading in China. Nature communications, 10(1), 1-8.碳笑风生关注全球和中国的能源转型、气候变化和可持续发展问题，特别是中国实现碳达峰、碳中和的科学、技术、政策、政治、经济、社会和文化问题。大家可以在小宇宙播客、喜马拉雅、网易云音乐等平台收听我们，我们同步更新的微信公众号“环境科学与政策”会有更多的专业讨论。大家也可以通过留言或在微信公众号“环境科学与政策”联系我们。开场、专场音乐来自The Podcast Host and Alitu: The Podcast Maker app.

本期我们关注的话题是中国最重要的市场化的气候变化政策——全国碳市场。从十二五规划开始碳排放权交易试点开始，中国的碳市场经过十年稳步推进，今年全国发电行业的碳交易市场有望正式上线。这期话题我们就聊聊碳税、碳市场政策的理论基础、在中国和世界的发展，以及碳税和碳市场到底作用几何。本期是这个话题的下半部分。【本期内容】第三部分：碳价格政策在世界的发展01:20 世界碳价格政策综述04:27 墨西哥和哈萨克斯坦这些发展中国家很早采用了碳价格政策07:00 世界范围内的碳价格和部门覆盖10:50 世界上的碳价格政策真的可以减排吗？18:30 碳价格政策会导致空气污染不平等减排吗？第四部分：碳价格政策可以帮我们实现碳中和吗23:30 “市场失灵”足以概括气候变化问题吗？28:26 政治、社会、技术、政策在气候变化应对的作用31:40 气候变化应对的紧迫性 ：行政手段vs.市场手段35:00 碳市场交易政策是“冗余”还是“兜底”？ 37:26 碳价格政策不能解决其他的市场失灵问题？41:25 碳价格政策与创新问题参考文献：“World Bank. 2020. State and Trends of Carbon Pricing 2020. Washington, DC: World Bank. © World Bank. https://openknowledge.worldbank.org/handle/10986/33809 License: CC BY 3.0 IGO.”Rafaty, R., Dolphin, G., & Pretis, F. (2020). Carbon pricing and the elasticity of CO2 emissions.Vance, E. (2012). Mexico passes climate-change law. Nature News.Green, J. F. (2021). Does carbon pricing reduce emissions? A review of ex-post analyses. Environmental Research Letters.Hernandez-Cortes, D., & Meng, K. C. (2020). Do environmental markets cause environmental injustice? evidence from california's carbon market (No. w27205). National Bureau of Economic Research.Rosenbloom, D., Markard, J., Geels, F. W., & Fuenfschilling, L. (2020). Opinion: Why carbon pricing is not sufficient to mitigate climate change—and how “sustainability transition policy” can help. Proceedings of the National Academy of Sciences, 117(16), 8664-8668.Azevedo, I., Davidson, M. R., Jenkins, J. D., Karplus, V. J., & Victor, D. G. (2020). The paths to Net Zero: How technology can save the planet. Foreign Aff., 99, 18.Zhu, J., Fan, Y., Deng, X., & Xue, L. (2019). Low-carbon innovation induced by emissions trading in China. Nature communications, 10(1), 1-8.碳笑风生关注全球和中国的能源转型、气候变化和可持续发展问题，特别是中国实现碳达峰、碳中和的科学、技术、政策、政治、经济、社会和文化问题。大家可以在小宇宙播客、喜马拉雅、网易云音乐等平台收听我们，我们同步更新的微信公众号“环境科学与政策”会有更多的专业讨论。大家也可以通过留言或在微信公众号“环境科学与政策”联系我们。开场、专场音乐来自The Podcast Host and Alitu: The Podcast Maker app.

本期我们关注的话题是中国最重要的市场化的气候变化政策——全国碳市场。从十二五规划开始碳排放权交易试点开始，中国的碳市场经过十年稳步推进，今年全国发电行业的碳交易市场有望正式上线。这期话题我们就聊聊碳税、碳市场政策的理论基础、在中国和世界的发展，以及碳税和碳市场到底作用几何。本期是这个话题的下半部分。【本期内容】第三部分：碳价格政策在世界的发展01:20 世界碳价格政策综述04:27 墨西哥和哈萨克斯坦这些发展中国家很早采用了碳价格政策07:00 世界范围内的碳价格和部门覆盖10:50 世界上的碳价格政策真的可以减排吗？18:30 碳价格政策会导致空气污染不平等减排吗？第四部分：碳价格政策可以帮我们实现碳中和吗23:30 “市场失灵”足以概括气候变化问题吗？28:26 政治、社会、技术、政策在气候变化应对的作用31:40 气候变化应对的紧迫性 ：行政手段vs.市场手段35:00 碳市场交易政策是“冗余”还是“兜底”？ 37:26 碳价格政策不能解决其他的市场失灵问题？41:25 碳价格政策与创新问题参考文献：“World Bank. 2020. State and Trends of Carbon Pricing 2020. Washington, DC: World Bank. © World Bank. https://openknowledge.worldbank.org/handle/10986/33809 License: CC BY 3.0 IGO.”Rafaty, R., Dolphin, G., & Pretis, F. (2020). Carbon pricing and the elasticity of CO2 emissions.Vance, E. (2012). Mexico passes climate-change law. Nature News.Green, J. F. (2021). Does carbon pricing reduce emissions? A review of ex-post analyses. Environmental Research Letters.Hernandez-Cortes, D., & Meng, K. C. (2020). Do environmental markets cause environmental injustice? evidence from california's carbon market (No. w27205). National Bureau of Economic Research.Rosenbloom, D., Markard, J., Geels, F. W., & Fuenfschilling, L. (2020). Opinion: Why carbon pricing is not sufficient to mitigate climate change—and how “sustainability transition policy” can help. Proceedings of the National Academy of Sciences, 117(16), 8664-8668.Azevedo, I., Davidson, M. R., Jenkins, J. D., Karplus, V. J., & Victor, D. G. (2020). The paths to Net Zero: How technology can save the planet. Foreign Aff., 99, 18.Zhu, J., Fan, Y., Deng, X., & Xue, L. (2019). Low-carbon innovation induced by emissions trading in China. Nature communications, 10(1), 1-8.碳笑风生关注全球和中国的能源转型、气候变化和可持续发展问题，特别是中国实现碳达峰、碳中和的科学、技术、政策、政治、经济、社会和文化问题。大家可以在小宇宙播客、喜马拉雅、网易云音乐等平台收听我们，我们同步更新的微信公众号“环境科学与政策”会有更多的专业讨论。大家也可以通过留言或在微信公众号“环境科学与政策”联系我们。开场、专场音乐来自The Podcast Host and Alitu: The Podcast Maker app.

第1期：全国碳市场开启的前夜：理想与现实之间（上）本期我们关注的话题是中国最重要的市场化的气候变化应对政策——全国碳交易市场。从十二五规划开始碳排放权交易试点开始，中国的碳市场经过十年稳步推进，今年全国发电行业的碳交易市场有望正式上线。这期话题我们就聊聊碳税、碳市场政策的理论基础、在中国和世界的发展，以及碳税和碳市场到底作用几何。本期是这个话题的上半部分。【本期内容】（上半部分）第一部分：碳税和碳市场的理论依据02:20 碳税和碳市场的环境经济学理论基础：外部性以及解决方案12:20 碳税 vs. 碳市场：相同与不同第二部分：全国碳市场的发展和设计17:03 中国为什么选择碳市场？18:30 中国碳市场的十年蓄力过程22:20 中国碳市场的经验和启发29:35 中国碳市场为什么要用强度基准？42:30 中国碳市场为什么当前只覆盖电力部门？46:38 中国碳市场如何分配碳配额？49:22 中国碳市场可以炒碳价吗？52:50 中国碳市场碳配额的抵消制度56:30 中国碳市场与其他环境政策的关系参考文献：Stavins, R. N. (2020). The future of US carbon-pricing policy. Environmental and energy policy and the economy, 1(1), 8-64. Goulder, L. H., & Schein, A. R. (2013). Carbon taxes versus cap and trade: a critical review. Climate Change Economics, 4(03), 1350010. Weitzman, M L (1974), “Prices vs. Quantities”, Review of Economic Studies 41(4): 477-91.Goulder, L. H., Morgenstern, R. D., Munnings, C., & Schreifels, J. (2017). China's national carbon dioxide emission trading system: An introduction. Economics of Energy & Environmental Policy, 6(2).Zhang, J., Wang, Z., & Du, X. (2017). Lessons learned from China's regional carbon market pilots. Economics of Energy & Environmental Policy, 6(2), 19-38Stavins, Robert N. Robert C. Stowe, eds. Subnational Climate Change Policy in China. Cambridge, Massachusetts: Harvard Project on Climate Agreements, February 2020.Pizer, W. A., & Zhang, X. (2018, May). China's New National Carbon Market. In AEA Papers and Proceedings (Vol. 108, pp. 463-67). Goulder, L. H., Long, X., Lu, J., & Morgenstern, R. D. (2019). China's Unconventional Nationwide CO2 Emissions Trading System: The Wide-Ranging Impacts of an Implicit Output Subsidy (No. w26537). National Bureau of Economic Research.Yi, L., Li, Z. P., Yang, L., Liu, J., & Liu, Y. R. (2018). Comprehensive evaluation on the “maturity” of China's carbon markets. Journal of Cleaner Production, 198, 1336-1344.Zhu, J., Fan, Y., Deng, X., & Xue, L. (2019). Low-carbon innovation induced by emissions trading in China. Nature communications, 10(1), 1-8.碳笑风生关注全球和中国的能源转型、气候变化和可持续发展问题，特别是中国实现碳达峰、碳中和的科学、技术、政策、政治、经济、社会和文化问题。大家可以在小宇宙播客、喜马拉雅、网易云音乐等平台收听我们，我们同步更新的微信公众号“环境科学与政策”会有更多的专业讨论。大家也可以通过留言或在微信公众号“环境科学与政策”联系我们。开场、转场音乐来自The Podcast Host and Alitu: The Podcast Maker app.

第1期：全国碳市场开启的前夜：理想与现实之间（上）本期我们关注的话题是中国最重要的市场化的气候变化应对政策——全国碳交易市场。从十二五规划开始碳排放权交易试点开始，中国的碳市场经过十年稳步推进，今年全国发电行业的碳交易市场有望正式上线。这期话题我们就聊聊碳税、碳市场政策的理论基础、在中国和世界的发展，以及碳税和碳市场到底作用几何。本期是这个话题的上半部分。【本期内容】（上半部分）第一部分：碳税和碳市场的理论依据02:20 碳税和碳市场的环境经济学理论基础：外部性以及解决方案12:20 碳税 vs. 碳市场：相同与不同第二部分：全国碳市场的发展和设计17:03 中国为什么选择碳市场？18:30 中国碳市场的十年蓄力过程22:20 中国碳市场的经验和启发29:35 中国碳市场为什么要用强度基准？42:30 中国碳市场为什么当前只覆盖电力部门？46:38 中国碳市场如何分配碳配额？49:22 中国碳市场可以炒碳价吗？52:50 中国碳市场碳配额的抵消制度56:30 中国碳市场与其他环境政策的关系参考文献：Stavins, R. N. (2020). The future of US carbon-pricing policy. Environmental and energy policy and the economy, 1(1), 8-64. Goulder, L. H., & Schein, A. R. (2013). Carbon taxes versus cap and trade: a critical review. Climate Change Economics, 4(03), 1350010. Weitzman, M L (1974), “Prices vs. Quantities”, Review of Economic Studies 41(4): 477-91.Goulder, L. H., Morgenstern, R. D., Munnings, C., & Schreifels, J. (2017). China's national carbon dioxide emission trading system: An introduction. Economics of Energy & Environmental Policy, 6(2).Zhang, J., Wang, Z., & Du, X. (2017). Lessons learned from China's regional carbon market pilots. Economics of Energy & Environmental Policy, 6(2), 19-38Stavins, Robert N. Robert C. Stowe, eds. Subnational Climate Change Policy in China. Cambridge, Massachusetts: Harvard Project on Climate Agreements, February 2020.Pizer, W. A., & Zhang, X. (2018, May). China's New National Carbon Market. In AEA Papers and Proceedings (Vol. 108, pp. 463-67). Goulder, L. H., Long, X., Lu, J., & Morgenstern, R. D. (2019). China's Unconventional Nationwide CO2 Emissions Trading System: The Wide-Ranging Impacts of an Implicit Output Subsidy (No. w26537). National Bureau of Economic Research.Yi, L., Li, Z. P., Yang, L., Liu, J., & Liu, Y. R. (2018). Comprehensive evaluation on the “maturity” of China's carbon markets. Journal of Cleaner Production, 198, 1336-1344.Zhu, J., Fan, Y., Deng, X., & Xue, L. (2019). Low-carbon innovation induced by emissions trading in China. Nature communications, 10(1), 1-8.碳笑风生关注全球和中国的能源转型、气候变化和可持续发展问题，特别是中国实现碳达峰、碳中和的科学、技术、政策、政治、经济、社会和文化问题。大家可以在小宇宙播客、喜马拉雅、网易云音乐等平台收听我们，我们同步更新的微信公众号“环境科学与政策”会有更多的专业讨论。大家也可以通过留言或在微信公众号“环境科学与政策”联系我们。开场、转场音乐来自The Podcast Host and Alitu: The Podcast Maker app.

第1期：全国碳市场开启的前夜：理想与现实之间（上）本期我们关注的话题是中国最重要的市场化的气候变化应对政策——全国碳交易市场。从十二五规划开始碳排放权交易试点开始，中国的碳市场经过十年稳步推进，今年全国发电行业的碳交易市场有望正式上线。这期话题我们就聊聊碳税、碳市场政策的理论基础、在中国和世界的发展，以及碳税和碳市场到底作用几何。本期是这个话题的上半部分。【本期内容】（上半部分）第一部分：碳税和碳市场的理论依据02:20 碳税和碳市场的环境经济学理论基础：外部性以及解决方案12:20 碳税 vs. 碳市场：相同与不同第二部分：全国碳市场的发展和设计17:03 中国为什么选择碳市场？18:30 中国碳市场的十年蓄力过程22:20 中国碳市场的经验和启发29:35 中国碳市场为什么要用强度基准？42:30 中国碳市场为什么当前只覆盖电力部门？46:38 中国碳市场如何分配碳配额？49:22 中国碳市场可以炒碳价吗？52:50 中国碳市场碳配额的抵消制度56:30 中国碳市场与其他环境政策的关系参考文献：Stavins, R. N. (2020). The future of US carbon-pricing policy. Environmental and energy policy and the economy, 1(1), 8-64. Goulder, L. H., & Schein, A. R. (2013). Carbon taxes versus cap and trade: a critical review. Climate Change Economics, 4(03), 1350010. Weitzman, M L (1974), “Prices vs. Quantities”, Review of Economic Studies 41(4): 477-91.Goulder, L. H., Morgenstern, R. D., Munnings, C., & Schreifels, J. (2017). China's national carbon dioxide emission trading system: An introduction. Economics of Energy & Environmental Policy, 6(2).Zhang, J., Wang, Z., & Du, X. (2017). Lessons learned from China's regional carbon market pilots. Economics of Energy & Environmental Policy, 6(2), 19-38Stavins, Robert N. Robert C. Stowe, eds. Subnational Climate Change Policy in China. Cambridge, Massachusetts: Harvard Project on Climate Agreements, February 2020.Pizer, W. A., & Zhang, X. (2018, May). China's New National Carbon Market. In AEA Papers and Proceedings (Vol. 108, pp. 463-67). Goulder, L. H., Long, X., Lu, J., & Morgenstern, R. D. (2019). China's Unconventional Nationwide CO2 Emissions Trading System: The Wide-Ranging Impacts of an Implicit Output Subsidy (No. w26537). National Bureau of Economic Research.Yi, L., Li, Z. P., Yang, L., Liu, J., & Liu, Y. R. (2018). Comprehensive evaluation on the “maturity” of China's carbon markets. Journal of Cleaner Production, 198, 1336-1344.Zhu, J., Fan, Y., Deng, X., & Xue, L. (2019). Low-carbon innovation induced by emissions trading in China. Nature communications, 10(1), 1-8.碳笑风生关注全球和中国的能源转型、气候变化和可持续发展问题，特别是中国实现碳达峰、碳中和的科学、技术、政策、政治、经济、社会和文化问题。大家可以在小宇宙播客、喜马拉雅、网易云音乐等平台收听我们，我们同步更新的微信公众号“环境科学与政策”会有更多的专业讨论。大家也可以通过留言或在微信公众号“环境科学与政策”联系我们。开场、转场音乐来自The Podcast Host and Alitu: The Podcast Maker app.

本期节目的嘉宾是我们的朋友吴桑。吴桑是美国卡内基梅隆大学Tepper商学院会计学博士候选人，研究方向是会计信息结构和经济激励。会计常常被看作是一种“实用”的技术，从审计到税收等很多情境下都需要会计学知识和职业人才帮助公司、个人完成投资等操作。但在实用之外，会计学为什么也是一门被教授、研究的学科呢？博士阶段的会计学研究和本科阶段的教育有什么不同？上市公司在准备财务报表时应该遵循哪些准则？这些准则又会如何影响公司、投资者的决策？在理解会计准则的作用之后，我们如何运用这些知识来帮助我们更好地进行个人投资？ 从瑞幸咖啡的财务造假讲起，吴桑和我们在这期节目中聊到了会计准则、服务对象、会计学的目的等话题。本期嘉宾吴桑内容提要+精彩预告00:35 嘉宾介绍01:00 什么是财报？04:00 会计学包含什么？财务会计：“公司希望利润越高越好”税务会计：“公司希望利润越低越好“管理会计：“公司希望信息越准确越好“05:50 以财务会计为例，会计学如何通过设计会计准则而服务于投资者？“投资者在进行投资决策时需要在不同的公司之间进行比较，如果每个公司采用不同的会计方法，公司之间就很难比较”“会计规则降低了投资者处理信息的成本”17:00 如此“实用”的会计学是一个学科吗？会计学领域研究什么？“本科教育培养学生运用规则准备会计信息，不是一个学科““博士阶段研究：拥有怎样特质的会计信息会引导投资者做出怎样的决定，又会怎样影响资源、资本的社会分配；拥有怎样特质的会计信息会影响公司是否主动披露这些信息”21:00 税务会计如何处理公司收益和政府税收的潜在矛盾？“经济学研究如何有效地配置资源；会计学研究在信息不对称的情况下，如何设计这些信息可以辅助配置资源的过程”“政府并不是希望税收越高越好”“会计学研究如何规范会计信息的准备过程，从而尽量减少信息不对称，帮助大家做更好的决定”27:30 理想世界下的完美信息对称为什么不存在？“没有一种衡量和传播信息的方式是完美的”30:00 会计准则的各个要素之间有什么需要权衡取舍的部分？Relevance-reliability tradeoff（相关性-可靠性权衡）Comparability tradeoff（可比性权衡）37:50 进入股市之前应该考察什么？“股票价格取决于公司本身的价值，和其他投资者对于公司价值的判断”“重要的是别人认为这个公司的价值高还是低”44:00 会计学在股票市场中扮演什么角色？——信息结构可以影响共识偶像行业的例子49:50 投资经验小分享“长期投资被舆论影响的程度较小”“短期投资卖出价格更多地取决于社会舆论”“需要知道公司财务报表的数字说明了什么”54:00 学习会计学如何影响了吴桑的生活？56:20 总结 参考资料互联网与娱乐怪盗团. (2020年04月06日). “瑞幸咖啡到底是怎么做假账的？——基于财报的分析.” 新浪财经-自媒体综合. 检索自https://finance.sina.com.cn/stock/stockzmt/2020-04-06/doc-iimxyqwa5255176.shtmlCorona, Carlos and Wu, Sang, "Heterogeneous Interpretations of Public Disclosure, Price Efficiency, and Keynesian Beauty Contests" (November 27, 2019). Available at SSRN: https://ssrn.com/abstract=3388309 or http://dx.doi.org/10.2139/ssrn.3388309Demski, J. S. (2007). Is accounting an academic discipline? Accounting horizons, 21(2), 153-157.Dye, Ronald A., and Sri S. Sridhar. "Reliability‐relevance trade‐offs and the efficiency of aggregation." Journal of Accounting Research 42.1 (2004): 51-88.Financial Accounting Standards Board. (Septermber 2010). “Conceptual Framework for Financial Reporting.” Statement of Financial Accounting Concepts No. 8. Retrieved from https://www.fasb.org/jsp/FASB/Document_C/DocumentPage?cid=1176157498129&acceptedDisclaimer=trueWu, Sang and Xue, Wenjie, "Optimal Comparability, Relative Accounting Performance, and Real Effects" (August 2, 2019). Available at SSRN: https://ssrn.com/abstract=3409454 or http://dx.doi.org/10.2139/ssrn.3409454 片头片尾音乐《Sunrise at Seaside》by 王乾 封面图片Portrait of Luca Pacioli (c. 1495–1500). Attributed to Jacopo de' Barbari. Retrieved from http://www.ritrattopacioli.it/.Luca Pacioli（1445–1517）开创了现在通用的复式记账法，被认为是会计学之父. -----------双重意识是一档「让我们认识到那些我们以为此时此刻与我们生活需求没有关联的东西其实和我们紧密相关」的播客节目。你可以在苹果播客, 喜马拉雅，网易云音乐，荔枝fm，小宇宙APP和Spotify搜索"双重意识DoubleConsciousness"找到我们，关注我们并收听我们的节目， 给我们留言、提供反馈意见。希望加入听友群的朋友可以关注公众号，后台回复“听友群”扫描二维码来和我们一起聊天。

In this episode, Dr. Donohoe and Dr. Panno discuss two of the most commonly used interventions, both in mainstream medical and functional medicine fields, Metformin and Berberine. Dr. Panno recently wrote a paper on this topic where he read through numerous research articles in order to gain more clarity and understanding of these two products (how they work and how effective they are). We get into the science behind them but also the clinical takeaways and what it all means. Below we reference all the articles used.    PLEASE SUBSCRIBE TO THE PODCAST For more Diabuddies content follow us on The Diabuddies Podcast Facebook page. Twitter: @TheDiabuddies Instagram: @thediabuddiespodcast You can email us at TheDiabuddiesPodcast@gmail.com  Time Stamps 1:10 - Start/Introduction 6:25 - Berberine: What Does It Do And How Effective Is It? 16:30 - Where Does Berberine Come From? 22:45 - Where Does Metformin Come From? 31:30 - How Does Metformin Work? (MOA) 39:50 - How Does Berberine Work? (MOA) 44:10 - Can you take Metformin and Berberine Together? 57:30 - Burst My Beta Cells   Resources/Links Discussed in the episode: References Arayne, M., Sultana, N., & Bahadur, S., (2007). The berberis story: berberis vulgaris in therapeutics. Park J Pharm Sci; 20(1): 83-92. PMID: 17337435 Bailey, C., & Day, C., (2004). Metformin: its botanical background. Pract Diabetes Int; 21: 115-117. https://doi.org/10.1002/pdi.606 Bailey, C., & Day, C., (1989). Traditional plant medicines as treatments for diabetes. Diabetes Care; 12(8): 553-564. PMID: 2673695 Center of Disease Control (2020). National Diabetes Statistic Report 2020, Estimates of Diabetes and its burden in the united states. Retrieved at: https://www.cdc.gov/diabetes/pdfs/data/statistics/national-diabetes-statistics-report.pdf Chang, W., Zhang, M., Li, J., Meng, Z., Wei, S., Du, H., Chen, L., & Hatch, G., (2013). Berberine improves insulin resistance in cardiomyocytes via activation of 5'adenosine monophosphate-activated protein kinase. Metabolism; 62(8): 1159-1167. PMID: 23537779 Chang, W., Chen, L., & Hatch, G., (2015). Berberine as a therapy for type 2 diabetes and its complication: from mechanism of action to clinical studies. Biochem Cell Biol; 93(5): 479-486. PMID: 19800084 Cheuh, W., & Lin, J., (2012). Protective effect of berberine on serum glucose levels in non-obese diabetic mice. International Immunopharmacology; 12(3): 534-538. PMID: 22266065 Choi, YH., & Lee, MG., (2006). Effects of enzyme inducers and inhibitors on the pharmacokinetics of metformin in rats: involvement of CYP2C11, 2D1, 3A1/2 for the metabolism of metformin. B J Pharmacol; 149(4): 424-30. PMID: 16940989 ClinCal (2020). The Top 200 Drugs of 2021. Medical Expenditure Panel Survey (MEPS). Retrieved at: https://clincalc.com/DrugStats/Top200Drugs.aspx Dong, H., Wang, H., Zhao, L., & Lu, F., (2012). Berberine in the treatment of type 2 diabetes mellitus: a systemic review and meta-analysis. Evidence Based complement alternative med; 2012: 591654. PMID: 23118793 Elbere, I., Kalnina, I., Silamikelis, I., Konrade, I., Zaharenko, L., Sekace, K., et al., Klovins, J., (2018). Association of metformin administration with gut microbiome dysbiosis in healthy volunteers. PLoS One; 13(9): e0204317. PMID: 30261008 Foretz, M., Herbrad, S., Leclerc, J., Zarrinpashneh, E., Soty, M., Mithieux, G., et al., & Viollet, B., (2010). Metformin inhibits hepatic gluconeogenesis in mice independently of LKB1/AMPK pathway via a decrease in hepatic energy state. The Journal of Clinical investigation; 120(7): 2355-2369. PMID: 20577053 Fullerton, M., Galic, S., Marcinko, K., Sikkema, S., Pulinikunnil, T., Chen, Z., et al., & Steinberg, G., (2013). Single phosphorylation sites in ACC1 and ACC2 regulate lipid homeostasis in the insulin-sensitizing effects of metformin. Nat Med; 19(12): 1649-1654. PMID: 24185692 Lan, J., Zhao, Y., Dong, F., Yan, Z., Zheng, W., Fan, J., & Sun, G., (2015). Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipemia, and hypertension. Journal of Ethnopharmacology; 16H: 69-81. PMID: 25498346 Le Bastard, Q., Grégoire, M., Chapelet, G., Javaudin, F., Dailly, E., Batard, E., Montassier, E., Al, G. G. A., & Knights, D. (2018). Systematic review: human gut dysbiosis induced by non‐antibiotic prescription medications. Alimentary Pharmacology & Therapeutics, 47(3), 332. PMID: 29205415  Li, Y., Wang, Y., Kong, W., Yang, P., Wang, Y., Li, Y., Yi, H., et al., & Jiang, J., (2011). Bioactivates of berberine metabolites after transformation throughout CYP450 isoenzymes. Journal of translational medicine; 9(62): 62. PMID: 21569619 Liang, Y., Xu, X., Yin, M., Zhang, Y., Haung, L., Chen, R., & Ni, J., (2019). Effects of berberine on blood glucose in patients with type 2 diabetes mellitus: a systematic literature review and meta-analysis. Endocrine Journal; 66(1): 51-63. PMID: 30393248 Lyu, Y., Zhang, Y., Yang, M., Lin, L., Yang, X., Cheung, S., et al., & Zuo, Z., (2019). Pharmacokinetic interactions between metformin and berberine in rats: Role of oral administration sequences and microbiota. Life Sciences; 235: 116818. PMID: 31473193 Mao, L., Chen, Q., Gong, K., Xu, X., Xie, Y., Zhang W., et al., & Zhang, Y., (2018). Berberine decelerates glucose metabolism via suppression of mTOR-dependent HIF-1α protein synthesis in colon cancer cells. Oncol Rep; 39(5). 2436-2442. PMID: 29565467 Miller, R., Chu, Q., Xie, J., Foretz, M., Viollet, B., & Birnbaum, M., (2013). Biguanides suppress hepatic glucagon signaling by decreasing production of cyclic AMP. Nature; 494(7436):256-260. PMID: 23292513 Neag, M., Mocan, A., Echeverria, J., Pop, R., Bocsan, C., Crisan, G., & Buzoianu, A., (2018). Berberine: Botanical Occurrence, Traditional Uses, Extraction Methods, and Relevance in Cardiovascular, Metabolic, Hepatic, and Renal Disorders. Front Pharmacology; 9: 557. PMID: 30186157 Owen, M., Doran, E., & Halestrap, A., (2000). Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondria respiratory chain. Biochem J; 348; 607-614. PMID: 10839993 Petersen, M., American Diabetes Association. Economic Costs of Diabetes in the U.S. in 2017. Diabetes care; 41(5): 917-928. PMID: 29567642 Pryor R., & Cabreiro F., (2015). Repurposing metformin: an old drug with new tricks in its binding pockets. Biochemical Journal; 471(3): 307-322. PMID: 26475449 Ren, G., Guo, J., Quian, Y., Kong, W., & Jiang, J., (2020). Berberine improves glucose and lipid metabolism in HepG2 cells through AMPKα1 activation. Front Pharmacology; 11: 647. PMID: 32457629 Yin, J., Xing, H., & Ye, J., (2008). Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism; 57(5): 712-717. PMID: 18442638 Yue, S., Liu, J., Wang, W., Wang, A., Yang, X., Guan, H., Wang, C., & Yan, D., (2019). Berberine treatment-emergent mild diarrhea associated with gut microbiota dysbiosis. Biomed Pharmacother; 116: 109002. PMID: 31154270 Zhang, H., Wei, J., Xue, R., Wu, J., Zhao, W., Wang, Z., et al., & Jiang, J., (2010). Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression. Metabolism; 59(2): 285-292. PMID: 19800084 Zhou, G., Myers, R., Li, Y., Chen, Y., Shen, X., Fenyk-Melody, J., et al., & Moller, D., (2001). Role of AMP-activated protein kinase in mechanisms of metformin action. The Journal of Clinical Investigation; 108(8): 1167-1174. PMID: 27654259

Welcome to the pursuit of mompreneurship podcast where we talk all things motherhood, mindset and entrepreneurship. I'm your host Xue, SAHM to four, fellow mom entrepreneur and social media and business coach for moms. Each week we dive deep into conversations that will educate, empower or entertain you on your journey as a mom entrepreneur. I hope this podcast serves you well and may the pursuit of mompreneurship continue to challenge, grow, reward and fulfill us as moms and entrepreneurs. If you find value in these episodes I'd love for you to leave a review and share it with a mama who needs to hear it too. 

It's Fat Xuanwu Week, so what can we say? Big episode, big turtle. We did the unthinkable and read three entire chapters: 53-55, parts 3-5 of the “Courage” arc! In these ones, Lan Wangji makes the Sophie's choice between “leg” or “virginity”,” Wei Wuxian uses how annoying he is medicine, and everybody has severe Tool Video Brain. Well, except for your hosts, who are too busy reminiscing about 1977 horror film Death Bed: The Bed That Eats. All this and a beautiful baby birthday treat for a beautiful baby birthday boy! Intro: Carly Rae Jepsen – I Really Like You, arr. & perf. by Olivia Lin Outro: Darude – Sandstorm, arr. & perf. by DJ Enculé Also used: Zu i Xue, Zheng Fanxing, Qi Peixin, & Guo Cheng (The Untamed OST) - Zui Shi Shao Nian Bu Ke Qi Noise Space | Patreon | Tumblr | Discord | Twitter | Fallon | Roy

รายการ สุขใจใกล้หมอ ใกล้หมอชะลอวัยกับหมอแอมป์ "ถั่งเช่า ดีจริงหรือไม่?" ตอนที่ 2 โดย หมอแอมป์ - นพ. ตนุพล วิรุฬหการุญ -ประธานเจ้าหน้าที่ปฏิบัติการ และ ผู้อำนวยการ BDMS Welness Clinic -ผู้อำนวยการ RoyalLife โรงพยาบาลกรุงเทพ -นายกสมาคมแพทย์ฟื้นฟูสุขภาพและส่งเสริมการศึกษาโรคอ้วน กรุงเทพ (BARSO) ออกอากาศทางช่อง PPTV HD 36 เมื่อ พ.ศ.2558 Keywords for Education: -Cordyceps Sinensis -Herbal Medicine -Lifestyle Medicine

รายการ สุขใจใกล้หมอ ใกล้หมอชะลอวัยกับหมอแอมป์ "ถั่งเช่า ดีจริงหรือไม่?" ตอนที่ 1 โดย หมอแอมป์ - นพ. ตนุพล วิรุฬหการุญ -ประธานเจ้าหน้าที่ปฏิบัติการ และ ผู้อำนวยการ BDMS Welness Clinic -ผู้อำนวยการ RoyalLife โรงพยาบาลกรุงเทพ -นายกสมาคมแพทย์ฟื้นฟูสุขภาพและส่งเสริมการศึกษาโรคอ้วน กรุงเทพ (BARSO) ออกอากาศทางช่อง PPTV HD 36 เมื่อ พ.ศ.2558 Keywords for Education: -Cordyceps Sinensis -Herbal Medicine -Lifestyle Medicine