Podcasts about Xue

Play Episode Listen Later Apr 17, 2024 2:44

The Ministry of Public Security has debunked a video that sparked a nationwide search after it was widely circulated on social media.一段视频在社交媒体上引发了全国范围内的传播和关注，公安部对此视频进行了辟谣。The video, depicting homework booklets supposedly lost by a Chinese first grader in Paris, was revealed to be a meticulously crafted ploy for online attention.这个描述中国一年级小孩秦朗在巴黎丢作业的视频，是为了吸引网络关注而精心制作的。The ministry's expose was part of a broader effort to combat online rumors. On Friday, it presented details of 10 prominent cases, highlighting the Paris homework incident as a prime example.公安部的曝光是打击网络谣言的一部分。4月12日，公安部介绍了10个突出案例的细节，其中以“秦朗丢作业”为主要例子。The video was uploaded in February by a blogger surnamed Xu, from Zhejiang province. It showed a Parisian restaurant worker supposedly returning homework found in a restroom. The video said the homework belonged to Qin Lang from Class Eight, without specifying the school. That sparked a social media frenzy, with many netizens attempting to locate the child.这段视频是2024年2月由一位来自浙江的徐姓博主上传的。视频显示，一名巴黎餐厅工作人员正在归还在洗手间发现的作业。视频称，该作业属于八班的秦朗，但没有指明是哪所学校。这在社交媒体上引起了轩然大波，许多网友都试图找到这个孩子。However, the narrative quickly unraveled. A user claiming to be Qin Lang's uncle appeared in the comments section, providing an unverified school name. Subsequent investigations revealed the person making the comment, a person surnamed Yang from Jiangsu province, was another participant in the scheme to gain online attention and was not related to Xu.然而，故事很快就被揭穿了。一位自称是秦朗舅舅的用户出现在评论区，提供了一个未经证实的学校名称。随后的调查显示，发表这番言论的人是来自江苏省的杨某，他是该骗局的另一参与者，目的是吸引网上的关注，与徐某没有关系。Further investigation by authorities exposed the entire charade. Police discovered that Xu, along with her company director, surnamed Xue, scripted the video, purchased generic homework booklets online and staged the entire scene.公安的进一步调查揭露了整个骗局。警方发现，徐某和她的公司经理薛某一起编写了视频，在网上购买了通用的作业手册，并上演了整个场景。Facing administrative penalties and demands for public apologies, Xu admitted her initial lack of "legal awareness" but expressed remorse for the widespread attention and disruption caused by the video. Her social media accounts, boasting millions of followers across many platforms, have been suspended.徐某遭到行政处罚并被要求公开道歉。她承认她最初缺乏“法律意识”，并对该视频引起的广泛关注和混乱表示歉意。她在多个平台上拥有数百万粉丝的社交媒体账户已被封号。The incident underscores China's intensifying efforts to combat online misinformation.这一事件凸显了中国正在加大打击网络虚假信息的力度。In December, the ministry launched a nationwide campaign against online rumors. Over 80,000 leads and 10,000 cases have been investigated, with over 1,500 suspects apprehended and 10,700 individuals facing administrative penalties.2023年12月，公安部在全国范围内发起了一场打击网络谣言的运动。调查了8万多条线索和1万多起案件，逮捕了1500多名犯罪嫌疑人，对10700人进行了行政处罚。The ministry has vowed to continue its crackdown, targeting individuals who spread rumors, fabricate news or exploit trending topics for personal gain. Law enforcement authorities will increase inspections of major social media, livestreaming and short video platforms to identify and address malicious online activity.公安部表示将继续打击那些散布谣言、编造新闻或利用热门话题谋取私利的个人。执法部门将加强对主要社交媒体、直播和短视频平台的检查，以识别和解决恶意网络活动。Meticulously细致地；一丝不苟地Rumor谣传，流言

china law chinese ministry police facing yang parisian subsequent xu zhejiang jiangsu public security xue

EZ News 03/28/24

EZ News

Play Episode Listen Later Mar 28, 2024 5:21

Good afternoon, I'm _____ with today's episode of EZ News. Tai-Ex opening The Tai-Ex opened up 13-points this morning from yesterday's close, at 20,213 on turnover of 4.5-billion N-T. The market staged a technical rebound on Wednesday as buying rotated to non-tech stocks. However, turnover was down from the previous trading days. Many investors remained wary of a major pullback after the main board scored solid gains in recent sessions to stand above the 20,000-point mark. Investors are also waiting for U-S economic data, which is due out later this week. First high-level Taiwan-France Trade Talks Focus on High-Tech The Ministry of Economics Affairs says representatives for Taiwan and France have held the first round of ministerial-level economic and trade talks. The talks focused on opportunities for collaboration (合作) in the high-tech supply chain. Taiwan's delegation was led by Economics Minister Wang Mei-hua, who met with representatives of France's Ministry of Economics and Finance. According to the economics ministry, the discussions covered possible partnerships in fields such as semiconductors, artificial intelligence, electric vehicles, renewable energy, and space industries. Carbon Fee Rate to be Decided in One to Two Months Environment Minister Xue Fu-sheng says it will take the government between one and two months to finalize the carbon fee rate. The Ministry of Environment was previously scheduled to announce the carbon fee rate in the first quarter of this year. The environment minister says the delay is because a review committee has not yet decided on the rate. However, Xue says there will be no change to the carbon fee collection schedule. The minister says the government still plans to collect (收) the fees beginning next year. WH: Talks with Israel on Gaza Operation Resume The White House says talks are resuming (恢復) to bring Israeli officials to the US to discuss Gaza operations. AP correspondent Ben Thomas reports. UN Food Waste Report A new United Nations report estimates that 19% of the food produced around the world went to waste in 2022. That's a little more than 1 billion metric tons of food. The updated Food Waste Index shows the biggest share of that waste, about 60%, came in households. Almost 30% came in food service operations, such as restaurants. This comes three years after the U.N.'s first attempt to quantify (量化) the problem as part of trying to cut food waste in half by the year 2030. That was the I.C.R.T. news, Check in again tomorrow for our simplified version of the news, uploaded every day in the afternoon. Enjoy the rest of your day, I'm _____. －－－－以下訊息由 SoundOn 動態廣告贊助商提供－－－－您是否聽過孩子抱怨：數學好無聊！數學好難！學數學真的只能是一直寫寫寫，不斷加減乘除嗎？提供孩子學習數學的新可能！《兒童數學動畫課》把數學變得好玩、好看又好用！輸入 CW150 再享專屬折扣～馬上點擊下方連結吧！ https://cplink.co/e71OXAa6

israel france ministry finance environment economics investors taiwan united nations israelis gaza decided nt u s soundon ben thomas xue

英语新闻丨Campaign to prevent coal mine accidents

Play Episode Listen Later Feb 14, 2024 4:34

China is launching a campaign targeting production safety accidents in coal mines following a newly enacted administrative regulation focused on the problem.中国正在开展一场针对煤矿生产安全事故的运动，此前刚刚颁布了一项针对这一问题的行政法规。The regulation was passed at the executive meeting of the State Council, China's Cabinet, last December and will be implemented in May.该条例于2023年12月在国务院常务会议上通过，将于2024年5月实施。Huang Jinsheng, head of the National Mine Safety Administration, said at a news conference held by the State Council Information Office on Sunday that coal mining, a traditionally high-risk industry, has always been a priority for production safety officials.2024年2月4日，国家矿山安全监察局局长黄锦生在国务院新闻办举行的新闻发布会上表示，煤矿作为传统的高危行业，一直是生产安全官员的首要关注点。He emphasized that as the nation seeks to further its socioeconomic development, there have been outstanding issues in coal mine production, such as the "inadequate implementation of safety production responsibilities, incomplete investigations, lax oversight of risks and hidden dangers, and an imperfect management system".他强调，随着国家寻求进一步的社会经济发展，煤矿生产中存在一些突出问题，如“安全生产责任制落实不到位、调查不全面、风险监管松懈、隐患多、管理制度不完善”等。The latest regulation was formulated against this backdrop, said Huang, noting that it's a foundational regulation in mining production safety, comprehensively summarizing the results of safety work in the field in recent years.黄锦生说，该条例就是在此背景下制定的。它是煤矿安全生产的基础性法规，全面总结了近年来该领域安全工作的成果。"The adoption of the regulation will help further implement the primary responsibility of coal mine enterprises in terms of safety production, and further strengthen supervision and monitoring responsibilities," he said.他说：“该条例的通过将有助于进一步落实煤矿企业在安全生产方面的主体责任，进一步加强监督和监测责任。” Production accidents in coal mines across the country have occurred frequently in recent times.近期，全国各地煤矿生产事故频发。In November, there was a major gas explosion at a coal mine in Heilongjiang province. The following month in Heilongjiang, there was an underground mine cart accident at another mine. The combined accidents resulted in 23 deaths and 13 injuries.11月，黑龙江省一煤矿发生重大瓦斯爆炸事故。12月，黑龙江另一煤矿发生井下矿车事故。两起事故共造成23人死亡，13人受伤。Also last month, another explosion happened at a coal mine in Henan province, causing 16 fatalities.就在上个月，河南省一煤矿又发生爆炸事故，造成16人死亡。According to the nation's chief mining production regulator, the regulation clearly stipulates that coal mine production should prioritize people's lives and property, adhering to the principle of "safety first".据国家煤矿生产监管部门负责人介绍，该条例明确规定，煤矿生产应当优先保障人民群众生命财产安全，坚持“安全第一”的原则。The regulation requires coal mine enterprises to regularly conduct safety inspections of their mines, marking the first time the relationship between coal mine enterprises and mines has been explicitly defined in administrative regulations.该条例要求煤矿企业定期对所属煤矿进行安全检查，这是行政法规中首次明确界定煤矿企业与煤矿之间的关系。The regulation also specifically demands that governments at the county level and above supervise and inspect coal mine enterprises, especially front-line production workplaces, said Huang, stressing that doing so increases the accountability of government officials.黄锦生说，该条例还特别要求县级以上政府监督和检查煤矿企业，特别是一线生产场所，这样做提高了政府官员的责任感。It's worth noting some local governments have allowed mines lacking safety guarantees to operate to ensure coal production and supply. Some grassroots governments "turn a blind eye" to illegal activities in coal mines within their jurisdictions, "even providing protection", according to another senior mining supervision official.值得注意的是，一些地方政府允许缺乏安全保障的矿山继续运营，以确保煤炭的生产和供应。另一位高级矿业监管官员表示，一些基层政府对辖区内煤矿的非法活动“视而不见”，“甚至提供保护”。Zhou Dechang, deputy head of the NMSA, underscored that safety must come first before ensuring coal production and supply.国家矿山安全监察局副局长周德昶强调，在确保煤炭生产和供应之前，安全必须放在首位。"They (local governments) cannot knowingly allow mines with significant safety risks to operate without shutting them down. Once a production safety accident occurs, ensuring coal mine production and supply is not an excuse to evade accident responsibility," he said.周德昶表示：“他们（地方政府）不能明知矿山存在重大安全隐患而允许其继续运营而不关闭。一旦发生生产安全事故，确保煤矿生产和供应并不是逃避事故责任的借口。”"Those who are directly responsible must be held accountable, and those suspected of illegal crimes should be transferred to judicial authorities for criminal prosecution."“对直接负责的人员必须追究责任，对涉嫌违法犯罪的人员应当移送司法机关追究刑事责任。”Some local coal mine enterprises prefer to pay the relatively low cost of the fines rather than comply with the law, production regulators said.生产监管部门表示，一些地方煤矿企业宁愿支付相对较低的罚款，也不愿遵守法律，。Xue Jianguang, director for policy and regulation at the NMSA, said penalties imposed by previous laws and regulations were too light.国家矿山安全监察局政策法规处处长薛剑光表示，此前法律法规规定的处罚过轻。To address this, the regulation further increases the cost of illegal activities for enterprises, including raising the minimum amount of fines, Xue said.薛剑光说，为了解决这一问题，该条例进一步增加了企业的违法成本，包括提高罚款的最低数额。"According to China's Production Safety Law, the minimum fines for enterprises involved in minor accidents is 300,000 yuan ($42,100); in relatively big accidents, 1 million yuan; and in major accidents 2 million yuan," he said. "The new regulation raises these minimum fines to 500,000 yuan for minor accidents, 1.5 million yuan for relatively big ones and 5 million yuan for major ones."“根据《中国安全生产法》，对发生一般事故的企业的最低罚款为30万元（4.21万美元）；发生较大事故的，罚款100万元；发生重大事故的，罚款200万元，新条例将这些最低罚款提高到一般事故50万元，较大事故150万元，重大事故500万元。”Coal Mine Production Safety Accidents煤矿生产安全事故 Judicial Prosecution司法追究

china production campaign prevent cabinet accidents huang coal mine henan state council xue heilongjiang nmsa

英语新闻丨Campaign to prevent coal mine accidents

entrepreneur goals reflections takeaways live events xue

Play Episode Listen Later Feb 6, 2024 4:34

China is launching a campaign targeting production safety accidents in coal mines following a newly enacted administrative regulation focused on the problem.中国正在开展一场针对煤矿生产安全事故的运动，此前刚刚颁布了一项针对这一问题的行政法规。The regulation was passed at the executive meeting of the State Council, China's Cabinet, last December and will be implemented in May.该条例于2023年12月在国务院常务会议上通过，将于2024年5月实施。Huang Jinsheng, head of the National Mine Safety Administration, said at a news conference held by the State Council Information Office on Sunday that coal mining, a traditionally high-risk industry, has always been a priority for production safety officials.2024年2月4日，国家矿山安全监察局局长黄锦生在国务院新闻办举行的新闻发布会上表示，煤矿作为传统的高危行业，一直是生产安全官员的首要关注点。He emphasized that as the nation seeks to further its socioeconomic development, there have been outstanding issues in coal mine production, such as the "inadequate implementation of safety production responsibilities, incomplete investigations, lax oversight of risks and hidden dangers, and an imperfect management system".他强调，随着国家寻求进一步的社会经济发展，煤矿生产中存在一些突出问题，如“安全生产责任制落实不到位、调查不全面、风险监管松懈、隐患多、管理制度不完善”等。The latest regulation was formulated against this backdrop, said Huang, noting that it's a foundational regulation in mining production safety, comprehensively summarizing the results of safety work in the field in recent years.黄锦生说，该条例就是在此背景下制定的。它是煤矿安全生产的基础性法规，全面总结了近年来该领域安全工作的成果。"The adoption of the regulation will help further implement the primary responsibility of coal mine enterprises in terms of safety production, and further strengthen supervision and monitoring responsibilities," he said.他说：“该条例的通过将有助于进一步落实煤矿企业在安全生产方面的主体责任，进一步加强监督和监测责任。” Production accidents in coal mines across the country have occurred frequently in recent times.近期，全国各地煤矿生产事故频发。In November, there was a major gas explosion at a coal mine in Heilongjiang province. The following month in Heilongjiang, there was an underground mine cart accident at another mine. The combined accidents resulted in 23 deaths and 13 injuries.11月，黑龙江省一煤矿发生重大瓦斯爆炸事故。12月，黑龙江另一煤矿发生井下矿车事故。两起事故共造成23人死亡，13人受伤。Also last month, another explosion happened at a coal mine in Henan province, causing 16 fatalities.就在上个月，河南省一煤矿又发生爆炸事故，造成16人死亡。According to the nation's chief mining production regulator, the regulation clearly stipulates that coal mine production should prioritize people's lives and property, adhering to the principle of "safety first".据国家煤矿生产监管部门负责人介绍，该条例明确规定，煤矿生产应当优先保障人民群众生命财产安全，坚持“安全第一”的原则。The regulation requires coal mine enterprises to regularly conduct safety inspections of their mines, marking the first time the relationship between coal mine enterprises and mines has been explicitly defined in administrative regulations.该条例要求煤矿企业定期对所属煤矿进行安全检查，这是行政法规中首次明确界定煤矿企业与煤矿之间的关系。The regulation also specifically demands that governments at the county level and above supervise and inspect coal mine enterprises, especially front-line production workplaces, said Huang, stressing that doing so increases the accountability of government officials.黄锦生说，该条例还特别要求县级以上政府监督和检查煤矿企业，特别是一线生产场所，这样做提高了政府官员的责任感。It's worth noting some local governments have allowed mines lacking safety guarantees to operate to ensure coal production and supply. Some grassroots governments "turn a blind eye" to illegal activities in coal mines within their jurisdictions, "even providing protection", according to another senior mining supervision official.值得注意的是，一些地方政府允许缺乏安全保障的矿山继续运营，以确保煤炭的生产和供应。另一位高级矿业监管官员表示，一些基层政府对辖区内煤矿的非法活动“视而不见”，“甚至提供保护”。Zhou Dechang, deputy head of the NMSA, underscored that safety must come first before ensuring coal production and supply.国家矿山安全监察局副局长周德昶强调，在确保煤炭生产和供应之前，安全必须放在首位。"They (local governments) cannot knowingly allow mines with significant safety risks to operate without shutting them down. Once a production safety accident occurs, ensuring coal mine production and supply is not an excuse to evade accident responsibility," he said.周德昶表示：“他们（地方政府）不能明知矿山存在重大安全隐患而允许其继续运营而不关闭。一旦发生生产安全事故，确保煤矿生产和供应并不是逃避事故责任的借口。”"Those who are directly responsible must be held accountable, and those suspected of illegal crimes should be transferred to judicial authorities for criminal prosecution."“对直接负责的人员必须追究责任，对涉嫌违法犯罪的人员应当移送司法机关追究刑事责任。”Some local coal mine enterprises prefer to pay the relatively low cost of the fines rather than comply with the law, production regulators said.生产监管部门表示，一些地方煤矿企业宁愿支付相对较低的罚款，也不愿遵守法律，。Xue Jianguang, director for policy and regulation at the NMSA, said penalties imposed by previous laws and regulations were too light.国家矿山安全监察局政策法规处处长薛剑光表示，此前法律法规规定的处罚过轻。To address this, the regulation further increases the cost of illegal activities for enterprises, including raising the minimum amount of fines, Xue said.薛剑光说，为了解决这一问题，该条例进一步增加了企业的违法成本，包括提高罚款的最低数额。"According to China's Production Safety Law, the minimum fines for enterprises involved in minor accidents is 300,000 yuan ($42,100); in relatively big accidents, 1 million yuan; and in major accidents 2 million yuan," he said. "The new regulation raises these minimum fines to 500,000 yuan for minor accidents, 1.5 million yuan for relatively big ones and 5 million yuan for major ones."“根据《中国安全生产法》，对发生一般事故的企业的最低罚款为30万元（4.21万美元）；发生较大事故的，罚款100万元；发生重大事故的，罚款200万元，新条例将这些最低罚款提高到一般事故50万元，较大事故150万元，重大事故500万元。”Coal Mine Production Safety Accidents煤矿生产安全事故 Judicial Prosecution司法追究

china production campaign prevent cabinet accidents huang coal mine henan state council xue heilongjiang nmsa

EZ News 12/07/23

EZ News

Play Episode Listen Later Dec 7, 2023 6:10

Good afternoon, I'm _____ with today's episode of EZ News. Tai-Ex opening The Tai-Ex opened marginally down this morning from yesterday's close, at 17,356 on turnover of 1.6-billion N-T. The market retreated from an early rise to end the day slightly higher on Wednesday - as Taiwan Semiconductor Manufacturing saw its gains eroded ( 削弱) ahead of the release of its November sales data. Investor sentiment also turned cautious ahead of the release of U-S nonfarm payroll data tomorrow, as many are waiting for more guidance on the Federal Reserve's monetary policy. Environment Minister in Dubai for COP28 Environment Minister Xue Fu-sheng is in Dubai for the COP28 meeting. According to Ministry of Environment, Xue is leading a delegation of other government officials to the two-week United Nations's annual climate change conference. Taiwan hasn't been formally invited to attend the conference, but officials are attending peripheral (週邊) meetings and holding talks on the sidelines of the event. The environment minister says he's been highlighting Taiwan's plans to reach climate goals and showcasing the government's resolution to pursue efforts to limit the average global temperature rise during those meetings in Dubai. Pufferfish that Killed 1 and Hospitalized 8 Others was "Inedible" And, The Food and Drug Administration says a poisonous pufferfish that was served by a restaurant owner in Nantou County last month has been identified as an lunartail puffer. The meal left one person dead and resulted in eight other people being hospitalized. According to the F-D-A, samples of the fish were sent for testing immediately following the man's death and D-N-A samples identified it as a lunartail puffer - which is an inedible (不可食用的) variety of the fish. The F-D-A says the lunartail puffer can be easily confused with species in the same genus that are edible when properly prepared. The sale, processing and producing of food stuffs made with pufferfish are illegal under the Act Governing Food Safety and Sanitation. US Ukraine Funding Stalls in Senate US President Joe Biden's push to pass tens of billions of dollars in new aid for Ukraine has stalled in the Senate. Republican lawmakers blocked the funding - which also includes help for Israel - in a protest over a dispute (爭議) about border security policy. Kate Fisher reports from Washington France Charges for Man Who Killed Tourist Near Eiffel Tower Prosecutors say a man accused of fatally stabbing a tourist and injuring two other people over the weekend near the Eiffel Tower has been placed under investigation on charges of murder and attempted murder in connection with a terrorist organization. The suspect went before an investigating magistrate Wednesday who ultimately decides preliminary charges. The stabbing over the weekend killed a German-Filipino tourist at a bridge near the tower. It has drawn special concern from French authorities less than a year before the 2024 Paris Olympics, whose opening ceremony is planned along the Seine river. The man had been under surveillance for suspected Islamic radicalization. Mexico Supreme Court Overturns Bullfighting Ban Mexico's Supreme Court has overturned (推翻) a 2022 ban on bullfighting in Mexico City, opening the way for events to resume, possibly as soon as this month. A panel of justices voted to overturn a May 2022 injunction that said bull fights violated city resident's rights to a healthy environment free from violence. The panel did not explain their arguments for overturning the ban, but fight organizers claimed it violated their right to continue the tradition. The capital had a history of almost 500 years of bullfighting, but there had been no fights since the 2022 injunction. That was the I.C.R.T. news, Check in again tomorrow for our simplified version of the news, uploaded every day in the afternoon. Enjoy the rest of your day, I'm _____.

israel french food ukraine ministry environment supreme court republicans investors dubai senate taiwan killed united nations islamic paris olympics nt drug administration eiffel tower u s sanitation hospitalized pufferfish environment minister xue kate fisher taiwan semiconductor manufacturing

Reflections From A Live Event: We Attended The Same Live Event With Different Goals. These Are Our Takeaways

Do the thing

Play Episode Listen Later Oct 23, 2023 52:31

What's the next step to grow your business? Entrepreneurs often reach a standstill when launching new ideas, but connecting with a welcoming, safe community can help your creative juices flow. Today's guests—Will, Mariana, Sara, Xue, Randi, and myself—all attended the same live event. We entered with varying intentions and left with similar takeaways. The people we met and the concepts we learned were nothing short of amazing. And we don't want to keep these lessons secret any longer! Here's how connecting with a safe, like-minded community will give you the clarity needed to take your business to the next level. Special Thanks to Eileen and Harrison Wilder and Jackie Lacroix for this incredible event !! Stay connected with today's inspirational guests: Will: Visit cashflowautomationworkshop.com to get in touch. Mariana: @brandmagnetic on Instagram and host of the Empire Secrets podcast Sara: @therealsaramoses on Instagram and host of the Do It Now podcast Xue: @xuebravo_ on Instagram and host of Making A Million podcast Randi: Follow Do The Thing Formula everywhere to see what's going behind the scenes.

Coevolução

Biologia em Meia Hora

Play Episode Listen Later Oct 13, 2023 32:33

As interações ecológicas são uma das principais forças que sustentam a biodiversidade da Terra. Um desafio para os estudos de ecologia e evolução é determinar como essas interações afetam a evolução entre pares ou redes de espécies. Separe trinta minutinhos do seu dia e descubra, com a Mila Massuda, como ocorrem os processos coevolutivos ou como as espécies, ao longo da história da Terra, dançam em uma interminável substituição de adaptações que criam laços complexos. Apresentação: Mila Massuda (@milamassuda) Roteiro: Mila Massuda (@milamassuda) e Emilio Garcia (@emilioblablalogia) Edição: @Matheus_Heredia (@mewmediaLAB) Produção: Prof. Vítor Soares (@profvitorsoares) e BláBláLogia (@blablalogia) REFERÊNCIAS: BENKMAN, Craig W.; HOLIMON, William C.; SMITH, Julie W. The influence of a competitor on the geographic mosaic of coevolution between crossbills and lodgepole pine. Evolution, v. 55, n. 2, p. 282-294, 2001. BENSON, Woodruff W.; BROWN JR, Keith S.; GILBERT, Lawrence E. Coevolution of plants and herbivores: passion flower butterflies. Evolution, p. 659-680, 1975. EHRLICH, Paul R.; RAVEN, Peter H. Butterflies and plants: a study in coevolution. Evolution, p. 586-608, 1964. MASSUDA, Kamila F.; TRIGO, R. Chemical defence of the warningly coloured caterpillars of Methona themisto (Lepidoptera: Nymphalidae: Ithomiinae). European Journal of Entomology, v. 106, n. 2, p. 253, 2009. MASSUDA, Kamila Ferreira. Multimodalidade de defesas em Ipomoea carnea subsp. fistulosa (Convolvulaceae) e em seus herbívoros, os besouros Cassidinae (Chrysomelidae). 2015. Tese de Doutorado. PAUW, Anton. Floral syndromes accurately predict pollination by a specialized oil‐collecting bee (Rediviva peringueyi, Melittidae) in a guild of South African orchids (Coryciinae). American Journal of Botany, v. 93, n. 6, p. 917-926, 2006. SASANI, Thomas A. et al. Large, three-generation human families reveal post-zygotic mosaicism and variability in germline mutation accumulation. Elife, v. 8, p. e46922, 2019. XUE, Yali et al. Human Y chromosome base-substitution mutation rate measured by direct sequencing in a deep-rooting pedigree. Current Biology, v. 19, n. 17, p. 1453-1457, 2009.

"When you have big dreams but your partner doesn't"

Soul CEO

Play Episode Listen Later Oct 11, 2023 11:28

S1 Ep8: What do you do when you have big goals and desires for your life but your partner is stuck in the nine-to-five corporate mindset? Xue called The Life Coach Hotline wondering how she can move forward with her dream life, despite her partner not sharing the same vision. Click here for full show notes, transcript, and more information: https://lindseymangocoaching.com/s1e8 If you want to call in to The Life Coach Hotline, go to lindseymango coaching.com/lifecoachhotline.

partner big dreams xue

How to Use Scheduling & Time Management to Win Back Your Personal Freedom with Xue #55

Life of Yegi's Podcast with Yegi Saryan

Play Episode Listen Later May 24, 2023 55:17

On this episode of The Yegi Project we speak to Xue, a freedom & time management coach. After realizing that her corporate job was giving her anxiety and negatively impacting her work/life balance, she and her boyfriend - now husband - decided to quit their jobs without a back-up plan. Even when things didn't go according to plan post quitting, she still found a way to push through the obstacles and successfully start multiple businesses all while having the freedom to travel whenever and wherever she wants. She now works with others to help them optimize their time and gain back their personal freedom as well.Follow Xue! https://www.instagram.com/xueunscripted/ https://stan.store/xueunscripted Follow The Yegi Project on Instagram! https://www.instagram.com/theyegiprojectMore About Your Host:Yegi is a young entrepreneur who has always been curious and hardworking. You can say she has always seen things out of the box and been able to creatively solve difficult problems. Her cool and collective spirit in life and business makes you want to be around her. She thrives on inspiring others and helps others see things from a positive point of view. The Yegi Project, is the podcast for the young entrepreneur who may not know where to start, doesn't have anyone to guide them in the right direction and may not have full support from others. This podcast is called The Yegi “Project” because although Yegi is happy with where she is now, she knows that she still has a lot to do to complete her mission and purpose in this world. She aims to use this podcast to work hard alongside all of you to grow to a point where she can make a lasting change in people's lives and in the world. If you would like to be a guest on a future episode of The Yegi Project, please email info@yegiproject.comThe Yegi Project is available on Apple Podcasts, Spotify, Stitcher and more!https://linktr.ee/theyegiprojectDisclaimer: This podcast or any other The Yegi Project episodes on this platform or other podcast streaming platforms is not legal business or tax advice. I make this content based on my own experience as a business owner and MBA for educational and entertainment purposes only.

spotify mba stitcher time management scheduling personal freedom win back podcast audio xue

#57 - Productividad para CUMPLIR METAS con Xue Neisa

Diario de una emprendedora

Play Episode Listen Later Apr 17, 2023 50:29

El día de hoy te traigo una entrevista super especial que tuve con Xue Neisa, una gran amiga y persona super especial en mi vida, con ella he aprendido mucho no solo sobre productividad, sino también mucho sobre amor propio, es más que una amiga, es una mentora y guía en mi vida. Y hoy nos habla sobre 4 aspectos claves que todos debemos trabajar para la consecución de nuestras metas. Instagram de XUE https://www.instagram.com/xueneisa/ Recuerda que puedes escribir por mi Instagram www.anngiavila.com/anngiavila o a mi correo podcastdiariodeunaemprendedora@gmail.com Recuerda que puedes comentar en mis redes sociales: ✒︎ ¿NOS SEGUIMOS EN REDES SOCIALES? ⬇ ✅ Twitter: https://twitter.com/AnngiAvila ✅ Facebook: https://www.facebook.com/AnngiAvila/ ✅ Instagram: https://www.instagram.com/anngiavila/ ✅ Pinterest: https://www.pinterest.com/anngiavila24/ --- Send in a voice message: https://podcasters.spotify.com/pod/show/anngiavila/message

pinterest recuerda metas cumplir productividad xue

Reduced Lead Setting for Diagnostic ECG Interpretation Using Deep Learning Models

Mayo Clinic Cardiovascular CME

Play Episode Listen Later Mar 30, 2023 14:17

Reduced Lead Setting for Diagnostic ECG Interpretation Using Deep Learning Models Guests: Joel Xue, Ph.D. Hosts: Anthony H. Kashou, M.D. (@anthonykashoumd) Joining us today to discuss what reduced-lead ECG analysis is, it's clinical value, some of its challenges, and how it compares to standard 12-lead ECG analysis is Joel Xue, Ph.D. Dr. Xue currently leads the AI group of AliveCor and is an adjunct professor of Bioinformatics department at Emory University, Atlanta, Georgia. Tune in to learn about using Deep learning models to reduce lead setting for diagnostic ECG interpretation. Specific topics discussed: What is reduced-12-lead ECG, and what is its clinical value? What are the main challenges for the reduced lead ECG analysis? How the Deep learning model method can be applied to reduced lead ECG analysis? Are the analysis performance comparable to the standard 12-lead ECG analysis? Next steps R&D and clinical use. Connect with Mayo Clinic's Cardiovascular Continuing Medical Education online at https://cveducation.mayo.edu or on Twitter @MayoClinicCV and @MayoCVservices. Facebook: MayoCVservices LinkedIn: Mayo Clinic Cardiovascular Services NEW Cardiovascular Education App: The Mayo Clinic Cardiovascular CME App is an innovative educational platform that features cardiology-focused continuing medical education wherever and whenever you need it. Use this app to access other free content and browse upcoming courses. Download it for free in Apple or Google stores today! No CME credit offered for this episode. Podcast episode transcript found here.

ai deep models interpretation mayo clinic emory university reduced diagnostic r d deep learning ecg bioinformatics alivecor xue

Navigating the Tech Job Market: Proven Tips For Job Search Success

Chan with a Plan

Play Episode Listen Later Mar 21, 2023 45:12

EPISODE SUMMARY In this episode of Chan with a Plan, Max Speaks with Xue Hua, software engineer in tech and Chief Tech Officer at Boba Talks. During this conversation Xue discusses her journey to getting her job in tech, overcoming obstacles, and preparing for tech company interviews. QUOTES FROM XUE “You'll feel like you're doing everything right, but you're still not landing an offer. It really depends on your learning style. Programming is an iterative process, so they just gave me the project. I didn't have to ask. I wasn't expecting it, and it was a big decision.” “It really depends on your learning style. I've had people learn from books. I've had people learn from Udemy videos. I've had people learn from practicing it.” “They saw that on my resume I had that freelance thing and that really set me apart from the other candidates because they had a problem with their current website or their current management system, and they needed somebody who understood how to make websites or applications. So that really helped me stand apart.” TIMESTAMPS [01:12] Xue's educational background [04:39] Difficulties in learning multiple coding languages [07:38] Resources for learning to code [09:56] Using internships and co-ops to help your career path [11:22] Preparing for first interviews [13:28] Gaining additional experience through projects in your job [16:20] Learning lessons when overcoming job search obstacles [19:07] Lacking the experience needed [20:35] Improving interview skills [24:45] Pivoting in your career [28:48] Tips for getting into top tech companies [33:37] Balancing offers while you wait for others [36:42] Culture shock [41:59] One big career challenge Xue had to overcame RESOURCES & RELEVANT LINKS Xue Hua on Social Media:LinkedIn Chan With A Plan Max Chan on Social Media

EZ News 11/30/22

EZ News

Play Episode Listen Later Nov 30, 2022 5:43

Good afternoon, I'm _____ with today's episode of EZ News. **Tai-Ex opening ** The Tai-Ex opened down 31-points this morning from yesterday's close, at 14,678 on turnover of 2.9-billion N-T. The market gained ground on Tuesday in a volatile (易變的) trading session, as investors were closely watching the situation in China. The market fluctuated by almost 300 points during the trading day. Semiconductor stocks led an initial downturn, but the local main board made a sharp rebound after investors opted to use temporary declines in the share prices to increase their holdings. **NHI Copayment Plan Could be Delayed ** Health Minister Xue Rui-yuan says plans to implement (實施) an increase in National Health Insurance copayments could be delayed depending on how the island's economy performs in the coming months. The plan is currently slated to be introduced sometime in the first quarter of next year. However, the health minister says an exact timeframe has not yet been decided, as the domestic coronavirus situation and how fast the island's economy can recover from the pandemic could affect the finalizing of an implementation date. Xue says his office will be making further assessments of the overall situation in the coming weeks. **Central Bank Head Cits Weak NT$ as Contributing to Inflation ** Central Bank Governor Yang Jin-long says the New Taiwan dollar will likely depreciate by around 6-per cent against the U-S dollar this year, driving up the price of imports and adding up to 0.3 percentage points to the consumer price index. According to Yang several factors have contributed to (成為因素) rising inflation in Taiwan over the last two years. They include coronavirus-era supply chain bottlenecks, the impact of the Russia-Ukraine war on food and energy prices, and Taiwan's vulnerability as a small economy to price fluctuations on international markets. While the other major factor is imported inflation, which has been driven up by both the rising costs of imported materials and products and by the depreciation of the New Taiwan dollar. **US Senate Passes SameSex Marriage Bill ** The U.S. Senate has passed a landmark (地標性的) bill protecting same-sex and interracial marriage across the country - and it did it with the support of both Democrats and Republicans. Toni Waterman has more. **Finland Calls for Weapons for Ukraine in NZ and Australia ** Finland's leader says it must give more weapons and support to Ukraine to ensure it wins its war against Russia. Prime Minister Sanna Marin made the comments today in Auckland as she embarked on the first-ever visit by a Finnish leader to New Zealand and Australia. Among the aims of the visit are improving diplomatic relations and trade ties. Since the war began, both Finland and Sweden have abandoned their longstanding policies of military nonalignment and applied to join NATO. That was the I.C.R.T. news, Check in again tomorrow for our simplified version of the news, uploaded every day in the afternoon. Enjoy the rest of your day, I'm _____.

china russia ukraine sweden republicans democrats senate weapons taiwan finland nato yang nz finnish auckland nt contributing u s semiconductors xue

101. Practices To Cope With Comparison To Others

Master Coaching with Ajit

Play Episode Listen Later Nov 4, 2022 34:10

Do you often find yourself comparing yourself to other people in your life? Or that you need to compete with others to get more love and attention? We all feel that way at some - or many - points in our lives, and it can negatively affect our energy and sense of worthiness. So how can we cope with these feelings effectively? In this episode, Coach Ajit coaches Xue Xia, who struggles with these negative thought spirals even when she's at her best in life and career. If you resonate with Xue or have clients in a similar situation, listen in on this conversation for powerful practices and ideas you can start implementing immediately. Key Insights: Understanding why we compare ourselves with others and how it affects our lives. The importance of managing one's energy. How to avoid negative downward spirals. The key to building meaningful relationships with friends. We are nurturing our sense of worthiness and self-love. How to identify triggers and set practices to cope with them. The role of routines and how it impacts our energy daily. Connect with us! IG: @realcoachajit IG: @evercoach FB: Evercoach by Mindvalley Website: www.evercoach.com Thank you so much for checking out this episode of Master Coaching with Ajit. If you enjoyed this episode, please leave us a rating and review on your favorite podcast app, and don't forget to subscribe to enjoy every new episode every single week.

comparison practices selfhelp cope self coaching ajit xue master coaching

August 2022 Discover CircRes

Discover CircRes

Play Episode Listen Later Aug 18, 2022 32:38

This month on Episode 39 of Discover CircRes, host Cynthia St. Hilaire highlights four original research articles featured in the August 5th and 19th issues of the journal. This episode also features an interview with Dr Annet Kirabo and Dr Ashley Pitzer from Vanderbilt University on their article, Dendritic Cell ENaC-Dependent Inflammasome Activation Contributes to Salt-Sensitive Hypertension. Article highlights: Jain, et al. Role of UPR in Platelets Orlich et al: SRF Function in Mural Cells of the CNS Xue et al: Gut Microbial IPA Inhibits Atherosclerosis Wang et al: Endothelial ETS1 on Heart Development Cindy St. Hilaire: Hi, welcome to Discover CircRes, the podcast of the American Heart Association's journal Circulation Research. I'm your host, Dr Cindy St. Hilaire from the Vascular Medicine Institute at the University of Pittsburgh, and today I'm going to be highlighting articles from our August 5th and August 19th issues of Circulation Research. I'm also going to have a chat with Dr Annet Kirabo and Dr Ashley Pitzer from Vanderbilt University about their study, Dendritic Cell ENaC-Dependent Inflammasome Activation Contributes to Salt-Sensitive Hypertension. But before I get to the interview, I first want to share an article from our August 5th issue, and that article is titled, Unfolded Protein Response Differentially Modulates the Platelet Phenotype. The first author of this study is Kanika Jain and the corresponding author is John Hwa from Yale University. Self-stress can lead to protein misfolding, and the accumulation of misfolded proteins can lead to a reduction in protein translation and may alter gene transcription, a process collectively known as the unfolded protein response, or UPR. UPR is well documented in nucleated cells; however, it has not been studied in platelets, which are anuclear, but do have a rapid response to cellular stress. In this study, they investigated the UPR in anucleate platelets and explore its role, if any, in platelet physiology and function. They found that treating human and mouse platelets with various stressors caused aggregations of misfolded proteins and induction of UPR-specific factors. Oxidative stress, for example, induced the UPR kinase PERK, while an endoplasmic reticulum stressor induced the transcription of the UPR factor XBP1. The team went on to study the UPR in platelets from people with type II diabetes, which is a population in which platelet mediated thrombosis is a major complication. They showed that protein aggregation and upregulation of the XBP1 pathway in diabetic patient platelets correlated with disease severity. Furthermore, treating the diabetic patient platelets with a chemical chaperone that helps to correct protein misfolding reduced protein aggregations and prevented the cells prothrombotic activation. This work confirms that even without transcription, platelets display stress-induced UPR, and that targeting this response may be a way to reduce thrombotic risk in diabetic patients. Cindy St. Hilaire: The second article I want to share with you is from our August 5th issue and is titled, Mural Cell SRF Controls Pericyte Migration, Vessel Patterning and Blood Flow, and it was led by Michael Orlich from Uppsala University in Sweden. Blood vessels are lined with endothelial cells and surrounded by mural cells. Vascular smooth muscle cells are the mural cells in the case of veins and arteries, and pericytes are the mural cells in the case of capillaries. In the capillaries, pericytes maintain blood-brain and blood-retina barrier function and can mediate vascular tone, similar to smooth muscle cells. While these pericytes and smooth muscle cells are related, they have distinct roles and characteristics. To learn more about the similarities and the differences between pericytes and smooth muscle cells, this group examined how each would be affected by the absence of SRF in the other. SRF is a transcription factor, essential for nonvascular or visceral smooth muscle cell function. In visceral smooth muscle cells, SRF drives expression of smooth muscle actin and other smooth muscle genes. Using mice engineered to lack SRF in mural cells, they show that SRF drives smooth muscle gene expression in these pericytes and smooth muscle cells, and its loss from smooth muscle cells causes atrial venous malformations and diminishes vascular tone. In pericytes, loss of SRF impaired cell migration in angiogenic sprouting. In a mouse model of retinopathy, activation of SRF drove pathological growth of pericytes. This work not only highlights the various functions of SRF in mural cell biology, but it also suggests that it has a role in pathological capillary patterning. Cindy St. Hilaire: The third article I want to share is from our August 19th issue of Circulation Research and is titled, Gut Microbially Produced Indole-3-Propionic Acid Inhibits Atherosclerosis by Promoting Reverse Cholesterol Transport and its Deficiency Is Causally Related to Atherosclerotic Cardiovascular Disease. The first authors are Hongliang Xue and Xu Chen, and the corresponding author is Wenhua Ling from Sun Yat-Sen University in Guangzhou, China. Recent studies provide evidence that disorders in the gut microbiota and gut microbiome derived metabolites affect the development of atherosclerosis. However, which and how specific gut microbial metabolites contribute to the progression of atherosclerosis and the clinical relevance of these alterations remain unclear. Gut microbiome derived metabolites, such as short-chain fatty acids and trimethylamine N-oxide, or TMAO, have been found to correlate with atherosclerotic disease severity. This study has now found that serum levels of indole-3-propionic acid, or IPA, are lower in atherosclerosis patients than controls. The team performed unbiased metagenomic and metabolomic analyses on fecal and serum samples from 30 coronary artery disease patients and found that, compared with controls, patients with atherosclerosis had lower gut bacterial diversity, depletion of species that commonly produce IPA and lower levels of IPA in their blood. Examination of a second larger cohort of atherosclerosis patients confirmed this IPA disease correlation. The team also showed serum IPA was reduced in a mouse model of atherosclerosis, and that supplementing such mice with dietary IPA could slow disease progression. Analysis of the macrophages from these mice showed that IPA increased cholesterol efflux, and the team went on to elucidate the molecular steps involved. The results of this study not only unraveled the details of IPA's influence on atherosclerosis, but suggest boosting levels of this metabolite could slow atherosclerotic disease progression. Cindy St. Hilaire: The last article I want to share is also from our August 19th issue, and it's titled, Endothelial Loss of ETS1 Impairs Coronary Vascular Development and Leads to Ventricular Non-Compaction. The first author is Lu Wang and the corresponding author is Paul Grossfeld, and they are at UCSD. Congenital heart defects, or CHDs, are present in nearly 1% of the human population. In some cases, the heart defects result from a genetic error, which can give researchers clues to its etiology. Jacobson syndrome is a complex condition caused by deletions from one end of chromosome 11, and the occurrence of a congenital heart defect in this syndrome has been associated with the loss of the gene ETS1. ETS1 is an angiogenesis promoting transcription factor, but how ETS1 functions in heart development was not known. Wang and colleagues now show that both global or endothelial-specific loss of ETS1 in mice caused differences in embryonic heart development that ultimately led to a muscular wall defect known as ventricular non-compaction. The mice also had defective coronary vasculogenesis associated with decreased abundance of endothelial cells in the ventricular myocardium. RNA sequencing of ventricular tissue revealed that, compared with controls, mice lacking ETS1 had reduced expression of several important angiogenesis genes and upregulation of extracellular matrix factors, which together contributed to the muscular and vascular defects. Cindy St. Hilaire: Today I have with me, Dr Annet Kirabo and Dr Ashley Pitzer, both from Vanderbilt University, and we're going to talk about their paper, Dendritic Cell ENaC-Dependent Inflammasome Activation Contributes to Salt-Sensitive Hypertension. This article is in our August 5th issue of Circulation Research. Thank you both so much for joining me today. Annet Kirabo: Yeah, thank you so much for having us. Ashley Pitzer: Yeah, thank you for having us. Cindy St. Hilaire: Yeah, it's a great paper. I think we're all familiar with hypertension and this idea that too much salt is bad for our cardiovascular system. When I was a kid, my grandparents had those salt replacements on their kitchen table, Mrs. Dash and whatever. But, like you said in the start of your paper, the exact mechanism by which salt intake increases blood pressure and also increases cardiovascular risk, it's not really well understood, and you guys are focusing on the contribution of immune responses in this process or in this pathogenesis. Before we dig into the details of your paper, I was wondering if you could give us a little bit of background about what's known regarding the role of inflammation in this salt-sensitive hypertension pathogenesis. Annet Kirabo: Yeah. It's difficult to know where begin to from, but the role of inflammation in cardiovascular disease have been known for many, many decades. Right now, Dr David Harrison showed more than 10 years ago that T cells contribute to hypertension, but the mechanisms were not known. Back when I was a post doc in David Harrison's lab, we discovered a new mechanism, how immune cells are activated in inflammation and hypertension, whereby we found that there is increased oxidative stress in antigen-presenting cells. This leads to formation of oxidative products known as arachidonic acid or lipid products known as isolevuglandin, or IsoLGs. These IsoLGs are highly, highly reactive and they adapt to lysines on proteins. This is a covalent binding, which leads to permanent alteration of proteins, and so these proteins act as neoantigens that are presented as self-antigens to T cells, leading to an autoimmune-like state in hypertension. Annet Kirabo: We found that these antigen-presenting cells are activated and they start producing a lot of cytokines that paralyze T cells to IL-17 producing T cells that contribute to hypertension. And so, when I started my lab back in 2016, we discovered that excess dietary salt profoundly activates this pathway, and we found for the first time that these antigen-presenting cells, they express ENaC, the epithelial sodium channel, and sodium goes into these antigen-presenting cells and activates the NADPH oxidase, which is an enzyme which produces this reactive oxygen species, leading to this IsoLG formation, which I've talked about, and leading to inflammation. So, three years ago when Ashley joined my lab, she had extensively studied the inflammasome in her PhD program, and she suggested why don't we look at the role of the inflammasome in this pathway and how IsoLG may contribute to this. In her paper that we are discussing right now, she found that in a dependent manner, sodium enters the cell and activates this pathway, and the NLRP3 inflammasome is involved in this process. Cindy St. Hilaire: That's such a wonderful story that fits together so many pieces. One of the things you talk about, which I guess I didn't even appreciate myself is, there are certain individuals out there who are more salt-sensitive than others. Annet Kirabo: Yeah. Cindy St. Hilaire: What is that difference? Do we know the root cause of that? And then also, how many individuals are we talking about are salt-sensitive? Annet Kirabo: Salt-sensitive blood pressure, it is a variable trait and it's normally distributed in the population, but it happens more in some individuals than others. It happens even in 25% of people without any hypertension. These people go to that doctor, that doctor thinks they're normal, they don't have any hypertension, but these people can be at a risk of sudden heart attack or cardiovascular risk or even a stroke, simply because when they eat a salty meal, their blood pressure will go up. Cindy St. Hilaire: Yeah, that's one of my questions. How much salt are we talking about here? And not only how much in a meal, but a sustained amount? How bad is a miso soup a day? Annet Kirabo: Yes. The American Heart Association and the World Health Organization have recommendations. American Heart Association recommends one spoon per day. We have refused to adapt to this recommendation, but that is the recommendation that they have recommended per day to eat. But this is difficult because most of the salt, as you know, is already in our food through processing in our processed foods and we don't have any control over how much salt we have, and there's also a lot of adding of salt at a table. Cindy St. Hilaire: Ashley, your background was more the inflammasome. What were your thoughts entering into this project? Did you have much of a hypertension background? Ashley Pitzer: No. My graduate thesis focused mainly on endothelial dysfunction and cardiovascular disease, and so it was a pretty easy segue. But it was just with Annet, so excited about the project and showing me all the data and this robust IL-1 beta production that she was seeing after these immune cells being exposed to high salt, I, with my inflammasome background, was immediately like, this could be playing a role. And so it was, like I said, a pretty easy transition and, as is in the paper, we're doing human studies. All of my research back in grad school was very basic research, so it was very exciting to see how our research was being translated with people having this condition and potentially finding mechanisms where we can target this to help actual people. Cindy St. Hilaire: I think a lot of us who are not in the hypertension field, and maybe this was you before you joined Annet's lab, we really only kind of think of the kidneys and the blood vessels when we think about hypertension, but studies like this are changing that. And I think a lot of Annet's earlier work, as well as the work of others, have shown a role for this epithelial sodium channel as an important player in this salt-induced hypertension. New to me, it's not just found in the kidney, which I totally did not appreciate that. And it's this channel sensing the salt that can trigger this IL-1 beta production that does a whole bunch of other things. Cindy St. Hilaire: What are those other things? What are those cells that are affected and where is this happening? Obviously it's not just kidney cells, but is it only in the kidney or are these systemic cells? What do we think is happening? Ashley Pitzer: That's the question, is, where is this happening? There's been studies at Vanderbilt by Jens Titze and his lab showing, where are these immune cells sensing the salt? And so they've shown that sodium accumulates in the skin, a huge argument is for they're sensing the sodium in the kidney because that's where a lot of it is being processed. But these immune cells travel through the whole body, so they're seeing it where there are the highest amounts of sodium concentration, and so I would argue it's in the kidney. Annet Kirabo: Indeed, because we're now collaborating with Tina Kon, and we have recently published with her a paper in the International Journal of Science, where we have done sodium MRI and we find this accumulation of sodium in the kidney even much more than in the skin. And we know that the kidney is where sodium is highly concentrated. So the working hypothesis in the lab is that these immune cells can be activated wherever they are, in the lymph nodes or not, in other tissues, but they can travel to the kidney. We find that in high salt, if you feed high salt to the mouse, the endothelium in the kidney becomes dysfunctional and it expresses molecules, chemoattractants, that attract these immune cells in the kidney. We think that the high salt accumulation in the kidney can activate these, and then these immune cells are activated and they produce cytokines. Dr Steve Crowley showed that they can produce IL-1 beta, which induces activation of sodium channels that can be induced. We have also actually found that even IL-17 can be produced by these immune cells in the kidney and they can activate sodium channels in the kidney, leading retention of sodium and water and hypertension. Cindy St. Hilaire: Very cool. You used a lot of mice in this paper. Can you tell us, I just want to know a little bit about the models you chose to use, but also how similar is hypertension in mouse and humans? Obviously for atherosclerosis, we have to do lots of things to get them to form a plaque. Is hypertension similar in a mouse and do mice also show this salt-sensitive phenotype? Annet Kirabo: That is an extremely important point. If you read our paper, we use a slightly different approach. Most people do benchside to bed approach. We did the opposite. We did a bed to benchside approach. Cindy St. Hilaire: Always smart. Annet Kirabo: Yeah. We first started humans, and then with some references, we went to the mice, because I think when it comes to salt-sensitive blood pressure, mice are different from humans. In fact, if we look in the lab, we find that female mice are protected from salt-sensitive blood pressure, but we find that in the humans, it's the opposite. Females are more prone to salt-sensitive hypertension. Those are studies that we are doing right now. We haven't published. But we know that it can be different. The model we use most of the time in the lab, the C57 mice, are resistant to salt-sensitive hypertension. These C57 mice would rather die before they raise their blood pressure in response to salt. We can induce salt-sensitivity in these mice like in the paper that we are discussing. When we induce the endothelial dysfunction using L-NAME and we wash it out, then these mice, when you give them, subsequently, salt, suggests that they become salt-sensitive. But we also have a salt-sensitive mouse model that we use, the 129/SV mouse. So we use several models to kind of prove the same thing over and over again with the findings that we found in humans. Cindy St. Hilaire: And you used a technique, which I'm a little bit familiar with, but I'd like to hear, A, about it from you, but also your experience in using it, and that is CITE-seq. So, how does that work? Ashley Pitzer: That was with our human study where we actually had patients come in, who were hypertensive, took them off medication for 2 weeks. They come in, we get baseline samples, we give them a salt load on one day, and then the next day we completely salt deplete them. Cindy St. Hilaire: How much is a salt load? Like a Big Mac? What's a salt load? Ashley Pitzer: Yeah, it's pretty much just like eating Lays chips all day. It's a lot of salt. It's a very salty meal. Annet Kirabo: And then in addition, we also infuse saline too. Cindy St. Hilaire: Oh, wow. Annet Kirabo: Because these people, when they come into the hospital, some them have already eating high salt. This approach is to just maximize the whole system so that then when we sort deplete everybody, it's at the same level and it's just to unify the whole process. But sorry, Ashley, you go ahead. Ashley Pitzer: With the CITE-seq, we're able to take different patients on different days. So we take samples each day, and we can give each sample a barcode, basically. Give them a barcode, we can pool them all together, process them, and we can sequence their RNA, we can probe for a certain amount of protein expression as well. So then when we analyze, we can look at protein expression, so you get the translation and the transcription for each person on each day, and then you're able to compare. And so you get this huge picture and it's a lot of data. Cindy St. Hilaire: How long did it take you to sort through? Ashley Pitzer: Well, we have a statistician who does all of that, because my wheelhouse is here and it is on a different planet. So we have somebody who helps us with that who does an unbiased approach. And then once he does an analysis, gives us back what are the things that are changing the most, and one of those was IL-1 beta. Annet Kirabo: As you can see, our list is huge, this is a massive input of so many collaborators. We have computational people on there that help us with this. I can't even begin to learn these techniques, but with all this collaboration and the resources at Vanderbilt, these things are possible. And so, this is a really powerful approach where you can combine protein expression and you get the specific cells that express the genes and you couple the channel type to the gene expression. Annet Kirabo: We actually found that not all monocytes are the same. There's a specific class that of monocytes, A small class of monocytes that is so angry, and the inflammasome is activated and producing this IL-1 beta, and that is enough to contribute to this phenotype of salt-sensitive hypertension, which dynamically changed according to blood pressure, suggesting that this is a targetable salt-sensitive blood pressure, even in normotensive people, is a targetable trait. And because these monocytes are in blood, can we get a blood sample and routinely diagnose salt-sensitive blood pressure so that doctors are aware and they can appropriately advise patients. Cindy St. Hilaire: This was samples obviously taken from a blood draw, right? So they're circulating. Annet Kirabo: It was a blood draw, yes. Cindy St. Hilaire: What do you think about these immune cells, perhaps, native in the kidney? Do you think the small population of angry cells, like you said, is escaping from the kidney environment? What do you think? Annet Kirabo: When I was a post-doc in David Harrison's lab, we found that the most angry dendritic cells that contribute to this inflammation and hypertension are monocyte-derived. So that's why in the human study we focused on monocytes, because there are so many subtypes of dendritic cells, plasmacytoid dendritic, classical dendritic cells. We have studied all of these subtypes, and we have focused on monocyte-derived dendritic cells because they're the ones that seem to be contributing to this phenotype the most. Cindy St. Hilaire: You guys focused in on the NLRP3 inflammasome, which, obviously it's a really critical component broadly for the innate immune system. Do you think that this is going to be a targetable approach that can be leveraged for hypertension? Or do you think it's too broad? What do you think about that as a therapeutic potential? Ashley Pitzer: Even when you look in our paper, and we use a knockout model, where we use a completely global knockout model, put them on high salt, and we give them back only dendritic cells that are from wild-type mice, so they have that NLRP3, that have been exposed to high salt. We were able to increase blood pressure, but I also did, in mice, where I gave them an IL-1 beta neutralizing antibody, similar to canakinumab, which is the CANTOS trial, and there's not much of a difference. There is, but it's minor. It's very minor. Ashley Pitzer: So, to be able to target in specific cell types in humans one thing, it's very difficult, and maybe one day we can get there. But I think it at least gives us a better idea of what is the full picture, what's the big mechanism going on with immune cells? In part of our human study, we are looking at something to try and be able to identify who is salt sensitive. So if anything, we're able to sit here and potentially have a way of identifying salt-sensitive patients, where, right now, all we can do is have them come in like we do and do a 3-day study, and not everybody can do that. Annet Kirabo: To add onto that, perhaps you know, we are talking about precision medicine. This is an era of precision medicine where you need to really tailor treatments if we can get there, and I think this is one way. CANTOS trial. They had no way of knowing who is salt-sensitive and who is not, it was a global approach, and the lack of differences in blood pressure might be explained that this IL-1 beta pathway is targetable in a specific population whose blood pressure is probably driven by inflammation. There are so many, many mechanisms that drive hypertension, and so perhaps we need to focus this on salt-sensitive people, and maybe we can really use this approach to target. Plus, this is ENaC-dependent. As you know, amiloride has lost favor in the clinic as a treatment of hypertension, because in the majority, it's not effective. But studies have shown that in Black men, for example, who had been categorized salt-resistant, when they give them amiloride, their blood pressure went down, and yet it's not effective in the majority of the people. So, can we bring back, can we take another look at amiloride. As our studies indicate that blockade of ENaC is anti-inflammatory and it's also antioxidant agent, can we at least bring back amiloride and look at it again and we focus it for specific populations of people that may be more prone to salt-sensitive hypertension? Here we have so many targets for potential precision treatment of salt-sensitive potential in this paper. You can target SGK1, which we know is possible, we listed a number of clinical trials that they have used NLRP3 inflammasome inhibitors, you can use amiloride for these people, and you can also potentially scavenge IsoLGs. Cindy St. Hilaire: What was the most challenging aspect of this study? There's a lot of moving parts, so what was the biggest challenge? And then, also, what was the most surprising part or the most pleasantly surprising part? Ashley Pitzer: You have to think, most of this was going on right when the pandemic hit. And right before that, we had started our human recruitment for the human study. And so that put a little bit of a time damper on it. Ashley Pitzer: Other than that, it was just, we were finding one thing, developing a new experiment, doing it again, doing it again. And honestly, what was the most surprising and rewarding was just seeing the same thing in, because we took just PBMCs from normotensive patients, treated them with high salt, and saw the changes that we did with the inflammasome. And to see that exactly again in an in vivo model of giving patients high salt and seeing the same thing, it was very rewarding and confirmed that, okay, we're on the right path. Seeing the same thing over and over and over again, it kind of reaffirms that you had a good idea. Annet Kirabo: I might add, one of the most challenging was, initially, the computational. Oh, part of the pandemic I was, the pandemic hit, I had a baby during the pandemic, and it was my time to leave my home, and then all these things were going on. We had a clinical trial where patients had to come in. Vanderbilt was so super supportive ,even checking for COVID-19. Our patients could not have COVID-19. We needed to check them. Cindy St. Hilaire: Yeah. Annet Kirabo: They also had to check for COVID-19. And so during that time, I realized, wait, I need learn computation analysis. I realized I cannot learn, and then reached out to collaborators that helped. That was extremely challenging. And then the other challenging thing that we faced later during the pandemic is vaccinations. In our criteria, these people cannot be vaccinated for reasons. We've studied inflammation, hypertension, and so vaccination was confounding. And even COVID-19 is even more for confounding. So we had this exclusion criteria where we could not recruit anyone. Annet Kirabo: Everybody was having COVID, everybody was being vaccinated, and everybody was in that exclusion criteria, so it was difficult to get people. We have had some slow down, but right now it's beginning to build up. Cindy St. Hilaire: So, what's next? What's the next question? Annet Kirabo: We have so many. Cindy St. Hilaire: That means it was a great study. If you have more, that means it was a great study. Annet Kirabo: Yeah. This study and us, it kind of warms. The inside seat just opened up, we have primary data in the genetic regulation of ENaC, we have primary data where we found. We are trying to figure out the specific ENaC channel in these antigen-presenting cells. We don't know. We found that ENaC delta, for example, it's not found in a kidney or you talked about a kidney contribution versus immune cells. ENaC delta is not found in the kidney, but we have primary data that show that ENaC delta is the most correlated with cardiovascular risk, is the most correlated with kidney disease and all forms of hypertension. So now we're like, ENaC delta expressed in the immune cells, not in the kidney, it is the one that is most involved in cardiovascular disease, so how are we going to tell the world that. Cindy St. Hilaire: Yeah, very cool. Annet Kirabo: Those cells, not necessarily the kidney. The kidney plays a part because the cells are going there, but it's very, very exciting. Plus a number of other lines that we are investigating. Cindy St. Hilaire: It's great. Well, congratulations, again, on this publication, on just getting all this done with what sounds like extremely difficult patient recruitment. So, Dr Kirabo and Dr Pitzer, thank you so much for joining me today and I'm looking forward to these next studies on maybe ENaC delta. Annet Kirabo: Thank you. Thank you so much. Ashley Pitzer: Thank you for having us. Cindy St. Hilaire: That's it for the highlights from the August 5th and August 19th issues of Circulation Research. Thank you for listening. Please check out the CircRes Facebook page and follow us on Twitter and Instagram with the handle @CircRes and hashtag Discover CircRes. Thank you to our guests, Dr Annet Kirabo and Dr Ashley Pitzer. This podcast is produced by Ashara Ratnayaka, edited by Melissa Stoner, and supported by the editorial team of Circulation Research. Some of the copy text for the highlighted articles is provided by Ruth Williams. I'm your host, Dr Cindy St. Hilaire, and this is Discover CircRes, your on the go source for the most exciting discoveries in basic cardiovascular research. This program is copyright of the American Heart Association 2022. Opinions expressed by speakers in this podcast are their own, and not necessarily those of the editors or of the American Heart Association. For more information, visit ahajournals.org.

How Did China Do in Its First Horn of Africa Peace Conference?

The China in Africa Podcast

Play Episode Listen Later Jun 25, 2022 33:47

China's Special Envoy for the Horn of Africa, Xue Bing, wrapped up a two-day peace conference in Addis Ababa last week, Beijing's first-ever effort to mediate conflicts outside of Asia. Xue personally offered to serve as a broker to help resolve many of the ongoing tensions that currently roil the region.Superficially, all of the participants responded favorably to China's efforts but the real test will come in the months ahead to see if Beijing can match its promises with tangible results.Aly Verjee, a non-resident senior advisor at the United States Institute of Peace, is a leading expert in the politics of the Horn of Africa. He joins Cobus to share his impressions of China's performance at the conference and whether he thinks Beijing has what it takes to help mediate the region's various conflicts.JOIN THE DISCUSSION:Twitter: @ChinaGSProject| @stadenesque | @alyverjeeFacebook: www.facebook.com/ChinaAfricaProjectFOLLOW CAP IN FRENCH AND ARABIC:Français: www.projetafriquechine.com | @AfrikChineعربي: www.akhbaralsin-africia.com | @AkhbarAlSinAfrJOIN US ON PATREON!Become a CAP Patreon member and get all sorts of cool stuff including our Week in Review report, an invitation to join monthly Zoom calls with Eric & Cobus, and even an awesome new CAP Podcast mug!www.patreon.com/chinaafricaprojectSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Weekly: LockBit PR Stunt Against Mandiant and Bohrium Targeted Users Via Spear-Phishing Operations

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Play Episode Listen Later Jun 10, 2022 30:45

ShadowTalk host Stefano alongside Xue, and Kim bring you the latest in threat intelligence. This week they cover: - LockBit x Mandiant PR stunt - Bohrium targets victims in various geographies Get this week's intelligence summary at: https://resources.digitalshadows.com/weekly-intelligence-summary/weekly-intelligence-summary-10-jun/ ***Resources from this week's podcast*** Killnet: The Hactivist Group That Started A Global Cyber War: https://www.digitalshadows.com/blog-and-research/killnet-the-hactivist-group-that-started-a-global-cyber-war/ -Ransomware Gangs and PR Stunts: Why LockBit Faked a Ransomware Attack Against Mandiant https://www.digitalshadows.com/blog-and-research/ransomware-gangs-and-pr-stunts-why-lockbit-faked-a-ransomware-attack-against-mandiant/

Weekly: The Return of Lapsus$, 2 Months of Russia-Ukraine War

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Play Episode Listen Later Apr 29, 2022 33:06

ShadowTalk host Stefano alongside Xue, Kim, & Rory bring you the latest in threat intelligence. This week they cover: * Cybercrime group Lapsus$ is back * Cyber activity in the Russia-Ukraine war so far ***Resources from this week's podcast*** The Russia – Ukraine War: Two Months In https://www.digitalshadows.com/blog-and-research/the-russia-ukraine-war-two-months-in/ Opportunity In The Midst Of Chaos: Russian-Speaking Cybercriminals Grapple With Sanctions And Forum Takedowns https://www.digitalshadows.com/blog-and-research/russian-speaking-cybercriminals-grapple-with-sanctions-and-forum-takedowns/ Leaked Chats Show LAPSUS$ Stole T-Mobile Source Code https://krebsonsecurity.com/2022/04/leaked-chats-show-lapsus-stole-t-mobile-source-code/ Subscribe to our threat intelligence email: https://info.digitalshadows.com/SubscribetoEmail-Podcast_Reg.html Also, don't forget to reach out to - shadowtalk@digitalshadows.com - if you have any questions, comments, or suggestions for the next episodes.

#28 - Chinese Medicine For Fertility- Woo-woo or Evidence-based?

Fertile Me Radio

Play Episode Listen Later Apr 13, 2022 20:04

I am an Integrative Fertility Expert with a background in Chinese medicine so obviously, I talk about it quite a bit. It is not the mainstream medical system in the United States, and there are lots of skepticism around it. Is it real? Is it woo-woo or is there evidence supporting its effectiveness? Those are the big questions that you are probably wondering about before embracing this system that is a few thousand years old to help you get pregnant. Today, I am going to present some of the evidence behind Chinese medicine and you can decide if it's legit or if it's too new agey for you. To follow me on Instagram, TikTok, and Facebook: @dradriennewei Reference: Feng, J., Wang, J., Zhang, Y., Zhang, Y., Jia, L., Zhang, D., Zhang, J., Han, Y., & Luo, S. (2021). The efficacy of complementary and alternative medicine in the treatment of female infertility. Evidence-based Complementary and Alternative Medicine : eCAM, 2021, 6634309. https://doi.org/10.1155/2021/6634309 Johansson, J., & Stener-Victorin, E. (2013). Polycystic ovary syndrome: effect and mechanisms of acupuncture for ovulation induction. Evidence-based Complementary and Alternative Medicine : eCAM, 2013, 762615. https://doi.org/10.1155/2013/762615 Liu, H., Xu, J. Y., Li, L., Shan, B. C., Nie, B. B., & Xue, J. Q. (2013). FMRI evidence of acupoints specificity in two adjacent acupoints. Evidence-based complementary and alternative medicine : eCAM, 2013, 932581. https://doi.org/10.1155/2013/932581 Liu, L., Liu, Y., Yang, M., Xu, G., Li, R., Xu, X., Pan, X., & Liang, J. (2020). Effectiveness of tonifying-kidney and regulating-liver therapy on diminished ovarian reserve: a systematic review and Meta-analysis of randomized controlled trials. Journal of Traditional Chinese Medicine = Chung i tsa chih ying wen pan, 40(3), 343–354. https://doi.org/10.19852/j.cnki.jtcm.2020.03.001 Maciocia, G. (2015). The foundations of Chinese medicine. Elsevier. Ried, K. (2015). Chinese herbal medicine for female infertility: an updated meta-analysis. Complementary Therapies in Medicine, 23(1), 116-128. https://doi.org/10.1016/j.ctim.2014.12.004 Zhang, C., & Xu, X. (2016). Advancement in the treatment of diminished ovarian reserve by traditional Chinese and Western medicine. Experimental and Therapeutic Medicine, 11(4), 1173–1176. https://doi.org/10.3892/etm.2016.3025

Weekly: Q1 Review Including Russia-Ukraine War, REvil Arrests, Emergence of Lapsus$ & More!

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Play Episode Listen Later Apr 1, 2022 30:20

ShadowTalk host Stefano alongside Kim, Xue, and Rick bring you the latest in threat intelligence. This week they cover a recap of a highly dynamic quarter including: * Log4j complex mitigation and remediation * REvil arrests * Cybercrime and Russia-Ukraine War * Extortion and the emergence of Lapsus$ ***Resources from this week's podcast*** Log4j: What's Happened Since https://www.digitalshadows.com/blog-and-research/log4j-whats-happened-since/ The Log4j Zero-Day: What We Know So Far https://www.digitalshadows.com/blog-and-research/the-log4j-zero-day-what-we-know-so-far/ Meet Lapsus$: An Unusual Group In The Cyber Extortion Business https://www.digitalshadows.com/blog-and-research/meet-lapsus-an-unusual-group-in-the-cyber-extortion-business/ How Cybercriminals Are Using Messaging Platforms https://www.digitalshadows.com/blog-and-research/how-cybercriminals-are-using-messaging-platforms/ Ransomware Q4 Overview https://www.digitalshadows.com/blog-and-research/ransomware-q4-overview/ Subscribe to our threat intelligence email: https://info.digitalshadows.com/SubscribetoEmail-Podcast_Reg.html Also, don't forget to reach out to - shadowtalk@digitalshadows.com - if you have any questions, comments, or suggestions for the next episodes.

Weekly: Conti Leaks, Reactions from Cybercriminals, & Priority Intelligence Requirements

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Play Episode Listen Later Mar 3, 2022 31:42

ShadowTalk host Stefano alongside Kim and Xue bring you the latest in threat intelligence. This week they cover: * Conti Leaks * Reactions from Cybercriminals * Priority Intelligence Requirements ***Resources from this week's podcast*** Russian Cyber Threats: Practical Advice For Security Leaders https://www.digitalshadows.com/blog-and-research/russian-cyber-threats-practical-advice-for-security-leaders/ Cybercriminals React To Ukraine-Russia Conflict https://www.digitalshadows.com/blog-and-research/cybercriminals-react-to-ukraine-russia-conflict/ Intelligence Requirements: Planning Your Cyber Response To The Russia-Ukraine War https://www.digitalshadows.com/blog-and-research/planning-your-cyber-response-to-the-russia-ukraine-war/ Conti Ransomware Group Diaries, Part I: Evasion https://krebsonsecurity.com/2022/03/conti-ransomware-group-diaries-part-i-evasion/ Subscribe to our threat intelligence email: https://info.digitalshadows.com/SubscribetoEmail-Podcast_Reg.html Also, don't forget to reach out to - shadowtalk@digitalshadows.com - if you have any questions, comments, or suggestions for the next episodes.

Career leave and building client relationships as a leading law firm Partner with Xue Wang

Lawyer on Air

Play Episode Listen Later Feb 6, 2022 71:59

The first woman partner at a major international law firm in Tokyo is my guest in the finale of Season Two of Lawyer on Air. Not only is she a Partner but she is about to take her second maternity leave, so this is an episode not to be missed for anyone considering taking leave to spend more time with their family or considering a sabbatical and wondering how it might affect your career. If you enjoyed this episode and it inspired you in some way, we'd love to hear about it and know your biggest takeaway. Head over to Apple Podcasts to leave a review and we'd love it if you would leave us a message here! In this episode you'll hear: How Xue overcame the challenge of doing a law degree in her third language Navigating being accepted for a trainee role in a top “Magic Circle” firm How Xue secured a secondment to a company in Japan Helping to create the maternity leave policy at her law firm and how a coach helped her to reframe the time out from her career How Xue is navigating taking a second maternity leave, this time as a Partner The danger of self imposed glass ceilings for women in their legal careers Her favourite book and other fun facts About Xue Xue is a Partner in Allen & Overy's Tokyo office, one of the leading international law firms globally, and specializes in the development and financing of energy and infrastructure projects, and on energy transition projects and initiatives. Xue's clients include leading international energy companies, financial institutions and government or multilateral agencies involved in these projects across the world, and she regularly works on a wide range of energy and infrastructure projects in Africa, the Middle East, Europe APAC and LatAm. Xue's practice also covers Japan and China, and prior to the pandemic she also used to spend a significant amount of time in China on a fly in fly out basis. Xue was born in China, but spent most of her formative years in Germany before moving to the UK for university. Since university, she has also lived in Paris, London, Brussels, Hong Kong and spent about 6 months travelling the world before starting her legal career. She joined A&O as a trainee in London in 2017 and has been with A&O ever since. In 2011, she had the opportunity to come to Japan for a client secondment with Mitsui bussan, where she spent 18 months on secondment, working as part of the infrastructure business unit. She rejoined A&O's Tokyo office in 2013 and has been building her practice and career here ever since, and was promoted as the first female partner in the Tokyo office in 2020. Xue is a mother of one (about to be two) and lives in Tokyo with her husband. She's passionate about promoting diversity and inclusion in the legal profession and would love to see more women and diversity in leadership positions. In her spare time, she likes to cook, snowboard, cycle, run and travel the world. Connect with Xue LinkedIn Links Mama Luisa's Restaurant: http://www.luisa-table.com/ How to avoid a climate change disaster by Bill Gates Connect with Catherine Linked In https://www.linkedin.com/in/oconnellcatherine/ Instagram: https://www.instagram.com/lawyeronair

S2E11: 7 Subconscious Zones - The Grey, Connections and Consciousness Combinations

Minh Gioi's Podcast

Play Episode Listen Later Sep 12, 2021 22:50 Transcription Available

The Grey is inherently divided into two parts: the mist and the grey maze. The mist is formed with combinations of clinging consciousness, or consciousness combinations in short, attached to one by physical matter, some of which are also known as genetic Xue-Jing consciousness combinations. Because of the genetic Xue-Jing consciousness combinations, one already has his own thinking traits inherited from his biological parents and ancestors before formation of his body. These durably-linked consciousness combinations have strong influences on one. Specifically, one might see ancestors' images, or communicate with them, or even mimic their sound frequencies.Written by Nhi TranEditted and narrated by Dung MaiImage by Huy NguyenDonate for us:

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科学家和学者呼吁，反对病毒溯源政治化

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Play Episode Listen Later Jul 29, 2021 4:28

Scientists, scholars say remove politics from virus debate科学家和学者呼吁，反对病毒溯源政治化Greater international cooperation on combating the COVID-19 pandemic is needed and less politicization of scientific issues, such as tracing the origin of the virus that causes the disease, according to Chinese scientists and scholars.中国科学家和学者表示，要加强国际合作，共同抗击疫情。要减少科学问题的政治化，如病毒溯源。Gao Fu, head of the Chinese Center for Disease Control and Prevention, said investigating the origin of the virus is a scientific question that should be answered scientifically.中国疾病预防控制中心主任高福称，病毒溯源是个科学问题，应该科学地回答。"Nobody should be blaming others. Probing the origin of the virus cannot be politicized," he said during the 23rd Annual Meeting of the China Association for Science and Technology, which started on Tuesday and ended on Wednesday.高福在周二至周三举行的第二十三届中国科协年会上说到：“谁都不要甩锅，病毒溯源不能政治化。”Gao said the pathogen may gain new properties by mutating and then breaching the body's immune system. Therefore, it is important to enhance international scientific cooperation based on openness, trust and collaboration, he added.高福称，病原体可能通过变异，破坏人体的免疫系统而获得新的特性。因此，加强以开放、信任和协作为基础的国际科学合作十分重要。Wang Hongyang, a noted oncologist and an academician of the Chinese Academy of Engineering, said the current public health challenges are unprecedented. "People are starting to realize that when a public health crisis hits, there is no such thing as a safe harbor," she said at the meeting. "We are all in this together, and only through international cooperation can we ensure global public health security."著名肿瘤学家、中国工程院院士王红阳说，当前公共卫生所面临的挑战是前所未有的。她在会上说：“人们开始意识到，当公共卫生危机来袭时，没有绝对安全的地方。我们都是命运共同体，只有通过国际合作，我们才能确保全球公共卫生的安全。”Wang said that since the COVID-19 outbreak, China has taken the "most comprehensive, rigorous and thorough measures" to curb the disease, allowing the country to go from being the most vulnerable to the virus to one of the safest nations in the world.王称，自疫情爆发以来，中国为遏制疫情采取了“最全面、最严格、最彻底的措施”，使中国从最易感染新冠病毒的国家走向世界上最安全的国家之一。China has also taken concrete actions to improve global public health in regard to the COVID-19 pandemic, including monetary donations to the World Health Organization and providing vaccines and aid to other countries.中国同时也针对新冠疫情采取了具体行动，以改善全球公共卫生。包括向世界卫生组织捐款，向其他国家提供疫苗和援助。"Only by respecting human lives as the upmost priority, along with enhancing cooperation and mutual assistance, can the international community form a collective force to tackle emerging public health crises and embrace a … healthy future," she said.“只有把尊重人的生命放在第一位，同时加强合作和互助，国际社会才能形成一支集体力量，来应对新的公共卫生危机，让未来我们国家的环境更健康，”她说到。Xue Lan, dean of Schwarzman College at Tsinghua University, said that after the end of the Cold War, international cooperation on science and technology rapidly expanded, but in recent years, political issues between major countries have undermined this momentum.清华大学苏世民学院院长薛澜说，冷战结束后，国际科技合作迅速扩大，但近年来，主要国家之间的政治问题破坏了这一势头。"All of humanity has benefited from global cooperation in science and technology," Xue said.“全人类都受益于全球科技合作，”薛澜说。Now, there are politicians whose agendas are interfering with the collaborative consensus among scientists, namely, that science has no borders, and science and technology should benefit all mankind, he said."The international scientific community must adamantly push back against these political challenges," he said.他说，现在有的政客的议程正在干扰科学家之间的合作共识，即“科学没有国界，科学技术应该造福全人类”。国际科学界必须坚决反击这些科学政治化现象。Kazuki Okimura, former president of the Japan Science and Technology Agency, said science exchanges and cooperation, such as those between China and Japan, are important for training talented people, building ties and promoting progress.日本科学技术厅前任理事长冲村宪树说，中日科技交流合作对培养人才、中日友好交流、促进进步具有重要意义。From 2013 until the COVID-19 outbreak in December 2019, Japan invited over 10,000 Chinese students and researchers to the country for exchange programs, Okimura said. However, the pandemic has put the program on hold for over 18 months.冲村宪树说，从2013年到2019年12月疫情爆发期间，日本邀请了1万多名中国学生和研究人员到日本进行交流项目。而疫情已使该计划搁置了18个多月。Although COVID-19 is largely under control in China, the rest of the world is still suffering the impact of the coronavirus and its variants. As a result, international relations will likely witness major changes in the future, he said. "This means China-Japan cooperation is growing more important than ever, and we look forward to building a relationship with China based on mutual learning and win-win collaboration."虽然新冠疫情在中国已基本得到控制，但世界其他地区仍在遭受新冠病毒及其变异毒株的影响。因此，今后国际关系可能会发生重大变化。“这意味着中日合作比以往任何时候都更加重要，我们期待着在相互学习、合作共赢的基础上与中国建立友好关系。”In an online opinion poll conducted by CGTN Think Tank, 80 percent of global respondents believe that the issue of COVID-19 origin tracing has been politicized.在CGTN智库进行的一项在线民意调查中，80%的全球受访者认为新冠病毒溯源问题已被政治化。Foreign Ministry spokesperson Zhao Lijian said on Wednesday that the United States was politically manipulating the origin probe, a move that has received widespread opposition in the international community.外交部发言人赵立坚周三表示，美国借溯源搞政治操弄的做法已遭到国际社会的普遍反对。"We solemnly inform the US－in the face of facts, science and justice－political manipulation will not win hearts and is doomed to fail," Zhao said.赵立坚称：“我们正告美方，在事实、科学、正义面前，政治操弄不得人心，只会以失败告终。”

covid-19 united states china science technology japan chinese engineering scientists prevention cold war world health organization wang disease control annual meetings government accountability office zhao probing tsinghua university foreign ministry cgtn chinese academy china japan although covid xue china association zhao lijian technology agency chinese center japan science

How to Grow Your Business using Instagram with Xue Bravo

Mom Owned and Operated

Play Episode Play 59 sec Highlight Listen Later May 12, 2021 17:55 Transcription Available

In this episode of the Mom Owned and Operated podcast, Rita Suzanne talks to Xue Bravo all about how she is raising a family, running a business and remembering herself. Xue is a wife, stay at home mom to four, multi business owner, social media and business strategist for new and aspiring mom entrepreneurs. She is on a mission to empower more moms to pursue their passions of owning a business and being the wonderful mama that they are. She does this by teaching them how to start, build and grow their business using simplified social media strategies. Grab the free Growth Guide from Xue to get you from 0-1k followers in less than 90 days! Listen to more interviews by visiting momownedandoperated.com and apply to work with Rita at ritasuzanne.com/apply/

第2期：全国碳市场开启的前夜：理想与现实之间（下）

Play Episode Listen Later Apr 16, 2021 51:31

本期我们关注的话题是中国最重要的市场化的气候变化政策——全国碳市场。从十二五规划开始碳排放权交易试点开始，中国的碳市场经过十年稳步推进，今年全国发电行业的碳交易市场有望正式上线。这期话题我们就聊聊碳税、碳市场政策的理论基础、在中国和世界的发展，以及碳税和碳市场到底作用几何。本期是这个话题的下半部分。【本期内容】第三部分：碳价格政策在世界的发展01:20 世界碳价格政策综述04:27 墨西哥和哈萨克斯坦这些发展中国家很早采用了碳价格政策07:00 世界范围内的碳价格和部门覆盖10:50 世界上的碳价格政策真的可以减排吗？18:30 碳价格政策会导致空气污染不平等减排吗？第四部分：碳价格政策可以帮我们实现碳中和吗23:30 “市场失灵”足以概括气候变化问题吗？28:26 政治、社会、技术、政策在气候变化应对的作用31:40 气候变化应对的紧迫性：行政手段vs.市场手段35:00 碳市场交易政策是“冗余”还是“兜底”？ 37:26 碳价格政策不能解决其他的市场失灵问题？41:25 碳价格政策与创新问题参考文献：“World Bank. 2020. State and Trends of Carbon Pricing 2020. Washington, DC: World Bank. © World Bank. https://openknowledge.worldbank.org/handle/10986/33809 License: CC BY 3.0 IGO.”Rafaty, R., Dolphin, G., & Pretis, F. (2020). Carbon pricing and the elasticity of CO2 emissions.Vance, E. (2012). Mexico passes climate-change law. Nature News.Green, J. F. (2021). Does carbon pricing reduce emissions? A review of ex-post analyses. Environmental Research Letters.Hernandez-Cortes, D., & Meng, K. C. (2020). Do environmental markets cause environmental injustice? evidence from california's carbon market (No. w27205). National Bureau of Economic Research.Rosenbloom, D., Markard, J., Geels, F. W., & Fuenfschilling, L. (2020). Opinion: Why carbon pricing is not sufficient to mitigate climate change—and how “sustainability transition policy” can help. Proceedings of the National Academy of Sciences, 117(16), 8664-8668.Azevedo, I., Davidson, M. R., Jenkins, J. D., Karplus, V. J., & Victor, D. G. (2020). The paths to Net Zero: How technology can save the planet. Foreign Aff., 99, 18.Zhu, J., Fan, Y., Deng, X., & Xue, L. (2019). Low-carbon innovation induced by emissions trading in China. Nature communications, 10(1), 1-8.碳笑风生关注全球和中国的能源转型、气候变化和可持续发展问题，特别是中国实现碳达峰、碳中和的科学、技术、政策、政治、经济、社会和文化问题。大家可以在小宇宙播客、喜马拉雅、网易云音乐等平台收听我们，我们同步更新的微信公众号“环境科学与政策”会有更多的专业讨论。大家也可以通过留言或在微信公众号“环境科学与政策”联系我们。开场、专场音乐来自The Podcast Host and Alitu: The Podcast Maker app.

第2期：全国碳市场开启的前夜：理想与现实之间（下）

Play Episode Listen Later Apr 16, 2021 51:31

本期我们关注的话题是中国最重要的市场化的气候变化政策——全国碳市场。从十二五规划开始碳排放权交易试点开始，中国的碳市场经过十年稳步推进，今年全国发电行业的碳交易市场有望正式上线。这期话题我们就聊聊碳税、碳市场政策的理论基础、在中国和世界的发展，以及碳税和碳市场到底作用几何。本期是这个话题的下半部分。【本期内容】第三部分：碳价格政策在世界的发展01:20 世界碳价格政策综述04:27 墨西哥和哈萨克斯坦这些发展中国家很早采用了碳价格政策07:00 世界范围内的碳价格和部门覆盖10:50 世界上的碳价格政策真的可以减排吗？18:30 碳价格政策会导致空气污染不平等减排吗？第四部分：碳价格政策可以帮我们实现碳中和吗23:30 “市场失灵”足以概括气候变化问题吗？28:26 政治、社会、技术、政策在气候变化应对的作用31:40 气候变化应对的紧迫性：行政手段vs.市场手段35:00 碳市场交易政策是“冗余”还是“兜底”？ 37:26 碳价格政策不能解决其他的市场失灵问题？41:25 碳价格政策与创新问题参考文献：“World Bank. 2020. State and Trends of Carbon Pricing 2020. Washington, DC: World Bank. © World Bank. https://openknowledge.worldbank.org/handle/10986/33809 License: CC BY 3.0 IGO.”Rafaty, R., Dolphin, G., & Pretis, F. (2020). Carbon pricing and the elasticity of CO2 emissions.Vance, E. (2012). Mexico passes climate-change law. Nature News.Green, J. F. (2021). Does carbon pricing reduce emissions? A review of ex-post analyses. Environmental Research Letters.Hernandez-Cortes, D., & Meng, K. C. (2020). Do environmental markets cause environmental injustice? evidence from california's carbon market (No. w27205). National Bureau of Economic Research.Rosenbloom, D., Markard, J., Geels, F. W., & Fuenfschilling, L. (2020). Opinion: Why carbon pricing is not sufficient to mitigate climate change—and how “sustainability transition policy” can help. Proceedings of the National Academy of Sciences, 117(16), 8664-8668.Azevedo, I., Davidson, M. R., Jenkins, J. D., Karplus, V. J., & Victor, D. G. (2020). The paths to Net Zero: How technology can save the planet. Foreign Aff., 99, 18.Zhu, J., Fan, Y., Deng, X., & Xue, L. (2019). Low-carbon innovation induced by emissions trading in China. Nature communications, 10(1), 1-8.碳笑风生关注全球和中国的能源转型、气候变化和可持续发展问题，特别是中国实现碳达峰、碳中和的科学、技术、政策、政治、经济、社会和文化问题。大家可以在小宇宙播客、喜马拉雅、网易云音乐等平台收听我们，我们同步更新的微信公众号“环境科学与政策”会有更多的专业讨论。大家也可以通过留言或在微信公众号“环境科学与政策”联系我们。开场、专场音乐来自The Podcast Host and Alitu: The Podcast Maker app.

第2期：全国碳市场开启的前夜：理想与现实之间（下）

Play Episode Listen Later Apr 16, 2021 51:31

本期我们关注的话题是中国最重要的市场化的气候变化政策——全国碳市场。从十二五规划开始碳排放权交易试点开始，中国的碳市场经过十年稳步推进，今年全国发电行业的碳交易市场有望正式上线。这期话题我们就聊聊碳税、碳市场政策的理论基础、在中国和世界的发展，以及碳税和碳市场到底作用几何。本期是这个话题的下半部分。【本期内容】第三部分：碳价格政策在世界的发展01:20 世界碳价格政策综述04:27 墨西哥和哈萨克斯坦这些发展中国家很早采用了碳价格政策07:00 世界范围内的碳价格和部门覆盖10:50 世界上的碳价格政策真的可以减排吗？18:30 碳价格政策会导致空气污染不平等减排吗？第四部分：碳价格政策可以帮我们实现碳中和吗23:30 “市场失灵”足以概括气候变化问题吗？28:26 政治、社会、技术、政策在气候变化应对的作用31:40 气候变化应对的紧迫性：行政手段vs.市场手段35:00 碳市场交易政策是“冗余”还是“兜底”？ 37:26 碳价格政策不能解决其他的市场失灵问题？41:25 碳价格政策与创新问题参考文献：“World Bank. 2020. State and Trends of Carbon Pricing 2020. Washington, DC: World Bank. © World Bank. https://openknowledge.worldbank.org/handle/10986/33809 License: CC BY 3.0 IGO.”Rafaty, R., Dolphin, G., & Pretis, F. (2020). Carbon pricing and the elasticity of CO2 emissions.Vance, E. (2012). Mexico passes climate-change law. Nature News.Green, J. F. (2021). Does carbon pricing reduce emissions? A review of ex-post analyses. Environmental Research Letters.Hernandez-Cortes, D., & Meng, K. C. (2020). Do environmental markets cause environmental injustice? evidence from california's carbon market (No. w27205). National Bureau of Economic Research.Rosenbloom, D., Markard, J., Geels, F. W., & Fuenfschilling, L. (2020). Opinion: Why carbon pricing is not sufficient to mitigate climate change—and how “sustainability transition policy” can help. Proceedings of the National Academy of Sciences, 117(16), 8664-8668.Azevedo, I., Davidson, M. R., Jenkins, J. D., Karplus, V. J., & Victor, D. G. (2020). The paths to Net Zero: How technology can save the planet. Foreign Aff., 99, 18.Zhu, J., Fan, Y., Deng, X., & Xue, L. (2019). Low-carbon innovation induced by emissions trading in China. Nature communications, 10(1), 1-8.碳笑风生关注全球和中国的能源转型、气候变化和可持续发展问题，特别是中国实现碳达峰、碳中和的科学、技术、政策、政治、经济、社会和文化问题。大家可以在小宇宙播客、喜马拉雅、网易云音乐等平台收听我们，我们同步更新的微信公众号“环境科学与政策”会有更多的专业讨论。大家也可以通过留言或在微信公众号“环境科学与政策”联系我们。开场、专场音乐来自The Podcast Host and Alitu: The Podcast Maker app.

第1期：全国碳市场开启的前夜：理想与现实之间（上）

Play Episode Listen Later Apr 11, 2021 63:21

第1期：全国碳市场开启的前夜：理想与现实之间（上）本期我们关注的话题是中国最重要的市场化的气候变化应对政策——全国碳交易市场。从十二五规划开始碳排放权交易试点开始，中国的碳市场经过十年稳步推进，今年全国发电行业的碳交易市场有望正式上线。这期话题我们就聊聊碳税、碳市场政策的理论基础、在中国和世界的发展，以及碳税和碳市场到底作用几何。本期是这个话题的上半部分。【本期内容】（上半部分）第一部分：碳税和碳市场的理论依据02:20 碳税和碳市场的环境经济学理论基础：外部性以及解决方案12:20 碳税 vs. 碳市场：相同与不同第二部分：全国碳市场的发展和设计17:03 中国为什么选择碳市场？18:30 中国碳市场的十年蓄力过程22:20 中国碳市场的经验和启发29:35 中国碳市场为什么要用强度基准？42:30 中国碳市场为什么当前只覆盖电力部门？46:38 中国碳市场如何分配碳配额？49:22 中国碳市场可以炒碳价吗？52:50 中国碳市场碳配额的抵消制度56:30 中国碳市场与其他环境政策的关系参考文献：Stavins, R. N. (2020). The future of US carbon-pricing policy. Environmental and energy policy and the economy, 1(1), 8-64. Goulder, L. H., & Schein, A. R. (2013). Carbon taxes versus cap and trade: a critical review. Climate Change Economics, 4(03), 1350010. Weitzman, M L (1974), “Prices vs. Quantities”, Review of Economic Studies 41(4): 477-91.Goulder, L. H., Morgenstern, R. D., Munnings, C., & Schreifels, J. (2017). China's national carbon dioxide emission trading system: An introduction. Economics of Energy & Environmental Policy, 6(2).Zhang, J., Wang, Z., & Du, X. (2017). Lessons learned from China's regional carbon market pilots. Economics of Energy & Environmental Policy, 6(2), 19-38Stavins, Robert N. Robert C. Stowe, eds. Subnational Climate Change Policy in China. Cambridge, Massachusetts: Harvard Project on Climate Agreements, February 2020.Pizer, W. A., & Zhang, X. (2018, May). China's New National Carbon Market. In AEA Papers and Proceedings (Vol. 108, pp. 463-67). Goulder, L. H., Long, X., Lu, J., & Morgenstern, R. D. (2019). China's Unconventional Nationwide CO2 Emissions Trading System: The Wide-Ranging Impacts of an Implicit Output Subsidy (No. w26537). National Bureau of Economic Research.Yi, L., Li, Z. P., Yang, L., Liu, J., & Liu, Y. R. (2018). Comprehensive evaluation on the “maturity” of China's carbon markets. Journal of Cleaner Production, 198, 1336-1344.Zhu, J., Fan, Y., Deng, X., & Xue, L. (2019). Low-carbon innovation induced by emissions trading in China. Nature communications, 10(1), 1-8.碳笑风生关注全球和中国的能源转型、气候变化和可持续发展问题，特别是中国实现碳达峰、碳中和的科学、技术、政策、政治、经济、社会和文化问题。大家可以在小宇宙播客、喜马拉雅、网易云音乐等平台收听我们，我们同步更新的微信公众号“环境科学与政策”会有更多的专业讨论。大家也可以通过留言或在微信公众号“环境科学与政策”联系我们。开场、转场音乐来自The Podcast Host and Alitu: The Podcast Maker app.

china lessons energy nature journal economics cambridge environmental prices podcast hosts li carbon yang wang ml comprehensive zhang liu schein economic research deng stowe environmental policy national bureau zhu yi morgenstern weitzman economic studies quantities xue pizer cleaner production climate change economics alitu the podcast maker climate agreements

第1期：全国碳市场开启的前夜：理想与现实之间（上）

Play Episode Listen Later Apr 11, 2021 63:21

第1期：全国碳市场开启的前夜：理想与现实之间（上）本期我们关注的话题是中国最重要的市场化的气候变化应对政策——全国碳交易市场。从十二五规划开始碳排放权交易试点开始，中国的碳市场经过十年稳步推进，今年全国发电行业的碳交易市场有望正式上线。这期话题我们就聊聊碳税、碳市场政策的理论基础、在中国和世界的发展，以及碳税和碳市场到底作用几何。本期是这个话题的上半部分。【本期内容】（上半部分）第一部分：碳税和碳市场的理论依据02:20 碳税和碳市场的环境经济学理论基础：外部性以及解决方案12:20 碳税 vs. 碳市场：相同与不同第二部分：全国碳市场的发展和设计17:03 中国为什么选择碳市场？18:30 中国碳市场的十年蓄力过程22:20 中国碳市场的经验和启发29:35 中国碳市场为什么要用强度基准？42:30 中国碳市场为什么当前只覆盖电力部门？46:38 中国碳市场如何分配碳配额？49:22 中国碳市场可以炒碳价吗？52:50 中国碳市场碳配额的抵消制度56:30 中国碳市场与其他环境政策的关系参考文献：Stavins, R. N. (2020). The future of US carbon-pricing policy. Environmental and energy policy and the economy, 1(1), 8-64. Goulder, L. H., & Schein, A. R. (2013). Carbon taxes versus cap and trade: a critical review. Climate Change Economics, 4(03), 1350010. Weitzman, M L (1974), “Prices vs. Quantities”, Review of Economic Studies 41(4): 477-91.Goulder, L. H., Morgenstern, R. D., Munnings, C., & Schreifels, J. (2017). China's national carbon dioxide emission trading system: An introduction. Economics of Energy & Environmental Policy, 6(2).Zhang, J., Wang, Z., & Du, X. (2017). Lessons learned from China's regional carbon market pilots. Economics of Energy & Environmental Policy, 6(2), 19-38Stavins, Robert N. Robert C. Stowe, eds. Subnational Climate Change Policy in China. Cambridge, Massachusetts: Harvard Project on Climate Agreements, February 2020.Pizer, W. A., & Zhang, X. (2018, May). China's New National Carbon Market. In AEA Papers and Proceedings (Vol. 108, pp. 463-67). Goulder, L. H., Long, X., Lu, J., & Morgenstern, R. D. (2019). China's Unconventional Nationwide CO2 Emissions Trading System: The Wide-Ranging Impacts of an Implicit Output Subsidy (No. w26537). National Bureau of Economic Research.Yi, L., Li, Z. P., Yang, L., Liu, J., & Liu, Y. R. (2018). Comprehensive evaluation on the “maturity” of China's carbon markets. Journal of Cleaner Production, 198, 1336-1344.Zhu, J., Fan, Y., Deng, X., & Xue, L. (2019). Low-carbon innovation induced by emissions trading in China. Nature communications, 10(1), 1-8.碳笑风生关注全球和中国的能源转型、气候变化和可持续发展问题，特别是中国实现碳达峰、碳中和的科学、技术、政策、政治、经济、社会和文化问题。大家可以在小宇宙播客、喜马拉雅、网易云音乐等平台收听我们，我们同步更新的微信公众号“环境科学与政策”会有更多的专业讨论。大家也可以通过留言或在微信公众号“环境科学与政策”联系我们。开场、转场音乐来自The Podcast Host and Alitu: The Podcast Maker app.

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第1期：全国碳市场开启的前夜：理想与现实之间（上）