Podcasts about Weinreb

In this video, Dr. Neal Weinreb, Voluntary Associate Professor for Human Genetics at the University of Miami Miller School of Medicine, answers questions asked by the audience during his CME/NCPD–approved activity with i3 Health, Exploring Treatment Advances for Acid Sphingomyelinase Deficiency (ASMD) in Adults. Dr. Weinreb shares insights into screening for lysosomal storage disorders, genetic carrier testing, resources for family and caregivers, the future of treatment with olipudase alfa, and more. Click the links below for the full activity! Online Accredited CME/NCPD Activity: https://www.i3health.com/course-information/exploring-new-treatment-advances-for-acid-sphingomyelinase-deficiency-in-adults Live or Virtual Meeting Series: https://www.i3health.com/live/exploring-new-treatment-advances-for-acid-sphingomyelinase-deficiency-in-adults-1

Rabbi Weinreb's Weekly Tefillah Chaburah is on Zoom at 10am on Sunday

Rabbi Weinreb's Weekly Tefillah Chaburah is on Zoom at 10am on Sunday

Paul (Harrison Weinreb) discusses finding his pal Ringo dead during their Everest Expedition, why he loves base camp (food trucks), and subtly hints at his time in a band. Brought to you By: The Sonar Network https://thesonarnetwork.com/

Rabbi Weinreb's Weekly Tefillah Chaburah is on Zoom at 10am on Sunday

Rabbi Weinreb's Weekly Tefillah Chaburah is on Zoom at 10am on Sunday

Rabbi Weinreb's Weekly Tefillah Chaburah is on Zoom at 10am on Sunday

Rabbi Weinreb's Weekly Tefillah Chaburah is on Zoom at 10am on Sunday

Rabbi Weinreb's Weekly Tefillah Chaburah is on Zoom at 10am on Sunday's

This week's featured guest on “613 Books Podcast” is Menachem Weinreb, Creative Director of Mishpacha Magazine. His newly-published ingeniously artful book, “Mystical Matters from the Bible and Beyond” was previewed on this podcast last summer when it was still in manuscript form. Back then, host Heather Dean predicted this book just might be The Next Big Thing, given all of its bold and whimsical illustrations, fanciful factoids, and surprising tales from the Talmud. Enjoy hearing from Menachem about the intricacies of making this book and the “joys” of shipping it to dozens of Kickstarter backers and other buyers, as well as a dramatic reading from the book by its versatile author. Remember to SUBSCRIBE to 613 Books Podcast and never miss an episode! ========= Show notes: Featured Guest: Menachem Weinreb, Creative Director, Mishpacha Magazine Author of "Mystical Matters from the Bible and Beyond” Contact Menachem either through his website: Amudart.com, or email: contact@amudart.com Instagram handles: @meweinreb, and @amudart Show Announcer for 613 Books Podcast: Michael Doniger Michael's contact info, voice-over samples, and demo: https://michaeldoniger.com/

Friedrich Weinreb 1 Der Podcast ist aus der Telegramgruppe in der Reinhard Lier regelmässig Themen aus "Ein Kurs in Wundern" bespricht. Link zum Telegramkanal unter https://t.me/ekiw_reinhards_kommentare Weitere Infos und Termine und eine APP mit alles Beiträgen unter www.reinhard-lier.com oder im Youtubekanal https://www.youtube.com/channel/UCQGC... Spenden gerne unter https://www.reinhard-lier.com/spenden/ weitere Infos zum Kurs unter https://www.zumkurs.de

Hörbuch von Reinhard Lier ist auch als kostenlose APP für Android-Systeme erhältlich: https://play.google.com/store/apps/details?id=com.werdinig.podcastapp Details & Kontaktinformationen: https://www.reinhard-lier.com Kostenlose Mediathek: https://www.lier-mediathek.com Allgemein rechtlicher Hinweis Es wird im Vortrag mehrmals auf folgendes Buch hingewiesen „Ein Kurs in Wundern“ (Titel der Originalausgabe „A Course in Miracles“), Greuthof Verlag und Vertrieb GmbH, ISBN 978-3-923662-18-0. Ein Kurs in Wundern, EKIW und A Course in Miracles sind als eingetragene Markenzeichen international geschützt. EKIW ist die Abkürzung für den Titel des Buches „Ein Kurs in Wundern“. Reinhard Lier sieht sich als Interpret und Vermittler von EKIW. Seine Vorträge, Podcasts und Seminare stellen seine persönliche Meinung dar und sind als unabhängig von den Rechteinhabern von EKIW (Deutschland: Greuthof-Verlag) zu sehen.

Hörbuch von Reinhard Lier ist auch als kostenlose APP für Android-Systeme erhältlich: https://play.google.com/store/apps/details?id=com.werdinig.podcastapp Details & Kontaktinformationen: https://www.reinhard-lier.com Kostenlose Mediathek: https://www.lier-mediathek.com Allgemein rechtlicher Hinweis Es wird im Vortrag mehrmals auf folgendes Buch hingewiesen „Ein Kurs in Wundern“ (Titel der Originalausgabe „A Course in Miracles“), Greuthof Verlag und Vertrieb GmbH, ISBN 978-3-923662-18-0. Ein Kurs in Wundern, EKIW und A Course in Miracles sind als eingetragene Markenzeichen international geschützt. EKIW ist die Abkürzung für den Titel des Buches „Ein Kurs in Wundern“. Reinhard Lier sieht sich als Interpret und Vermittler von EKIW. Seine Vorträge, Podcasts und Seminare stellen seine persönliche Meinung dar und sind als unabhängig von den Rechteinhabern von EKIW (Deutschland: Greuthof-Verlag) zu sehen.

Hörbuch von Reinhard Lier ist auch als kostenlose APP für Android-Systeme erhältlich: https://play.google.com/store/apps/details?id=com.werdinig.podcastapp Details & Kontaktinformationen: https://www.reinhard-lier.com Kostenlose Mediathek: https://www.lier-mediathek.com Allgemein rechtlicher Hinweis Es wird im Vortrag mehrmals auf folgendes Buch hingewiesen „Ein Kurs in Wundern“ (Titel der Originalausgabe „A Course in Miracles“), Greuthof Verlag und Vertrieb GmbH, ISBN 978-3-923662-18-0. Ein Kurs in Wundern, EKIW und A Course in Miracles sind als eingetragene Markenzeichen international geschützt. EKIW ist die Abkürzung für den Titel des Buches „Ein Kurs in Wundern“. Reinhard Lier sieht sich als Interpret und Vermittler von EKIW. Seine Vorträge, Podcasts und Seminare stellen seine persönliche Meinung dar und sind als unabhängig von den Rechteinhabern von EKIW (Deutschland: Greuthof-Verlag) zu sehen.

Rabbi Weinreb's Weekly Tefillah Chaburah is on Zoom at 10am on Sunday's

Rabbi Weinreb's Weekly Tefillah Chaburah is on Zoom at 10am on Sunday's

Rabbi Weinreb's Weekly Tefillah Chaburah is on Zoom at 10am on Sunday's

Live Tefillah Chaburah with Rabbi Weinreb every Sunday at 10am

This week's guest was one of the most requested guests of 2023. Podcaster, Author, and “Entrepreneur” Jackie Oshry Weinreb is back! Shannon and Jackie bond over getting fired from their corporate jobs, and Jackie shares how The Toast really started. Boy jobs, Millennial vs Gen Z, and their Tiktok For You pages, Jackie and Shannon catch up on all things life and social media. Jackie shares how she balances work and being a mom, her breastfeeding journey, and, of course, her push presents. Where does Jackie get her impressive vocabulary? How do they feel about circumcision? The duo wrap things up sharing their ins and outs for 2024, and they don't care what you think of them. It's Episode 90, and the girls can confirm: Everyone Gets Fired.Follow Shannon: https://instagram.com/probablyshannon/Follow Jackie: https://www.instagram.com/jackieoshryFollow Probably A Podcast: https://instagram.com/probablyapodcast/Watch the full episode on YouTube: https://www.youtube.com/probablyshannonfordProduced by Dear MediaSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Join us for a compelling debate between Adar Weinreb and Jean-François Gariépy on the Jewish Question. This video features an engaging discussion, providing a variety of perspectives on a complex and historical topic.Support the show

Tefillah Chaburah with Rabbi Weinreb every Sunday on Zoom

Tefillah Chaburah every Sunday on Zoom

Tefillah Chaburah with Rav Tzvi Hersh Weinreb every Sunday on Zoom

July 30, 2021

This shiur was delivered on 12/3/23

Tefillah Chaburah every Sunday Morning on Zoom

Tefillah Chaburah is on zoom each Sunday

This shiur was delivered 12/10/23

This shiur was delivered 12/3/23

Pre-chanukah

Eric is joined on this week's podcast by Solvency Now founder Maya Weinreb where they both discuss how they turned what was a side hustle into a million dollar plus business, and why failing is not failure.     Want to connect with Maya? https://solvencynow.com/

Sunday morning on Zoom at 10am

Tefillah Chaburah every Sunday at 10am

Tefillah Chaburah is on Zoom every Sunday morning at 10am

Let's unravel the complex and deeply-rooted Israeli-Palestinian conflict with our guest, Adar Weinreb, a former Israeli Defense Forces soldier turned peace advocate. As someone who's been on the front lines, Adar brings a unique perspective to the conversation, revealing his transformative journey from soldier to advocate, and the importance of humanizing 'the other' when navigating such deep-rooted conflict. His experiences and insights offer a rich understanding of how to facilitate dialogue in divisive cultural landscapes. We step back to explore the historical roots of Israeli-Palestinian conflict and the importance of focusing on the present and future, rather than dwelling on the past. Through this lens, we delve into the power dynamics between Israel and Palestine, as well as the broader Arab region's influence on this ongoing conflict. We also examine the potential implications of attempting to defeat Hamas, and contemplate alternative solutions that could change the status quo, reduce civilian casualties, and pave the way towards lasting peace. As we navigate these intricate waters, we also ponder the potential for broader escalation involving Iran and Hezbollah in the Israeli-Hamas conflict. We discuss the complex history of U.S. support for Islamist governments in the Middle East, the challenges of nation-building, and the potential consequences of ground invasions and long-range missile attacks. Despite the current context of conflict and tension, we remain hopeful for a brighter future, a resolution to these long-standing issues, and a path towards peace. Join us for this enlightening exploration of a deeply-rooted conflict from someone who's been in the thick of it.12:37 Israeli-Palestinian Conflict Historical Roots26:26 The Implications of Defeating Hamas32:09 Potential Escalation in Israeli-Hezbollah ConflictMusic: Coma-Media (intro)                 WinkingFoxMusic (outro)Recorded: 10/25/23

My beautiful friend Kim Weinreb shares love and relationship insights today on Lovin My Daughter-in-law Podcast. Kim helps parents who have teens with special needs transition from childhood support & services into adult support & services, which in the special needs world is very complicated.  More information at: https://www.transitionallyspeaking.com/ Listen to hear Kim's insights and how love is the foundation for everything she does

Delivered on Sunday, 10-29-23. Our Tefillah Chaburah is on Zoom every Sunday morning.

Dalia is a registered dietician with years of experience and she's here to help you understand more about the power of healing the gut on the alcohol-free journey! It was such a pleasure to speak to a medical professional with plenty of clinical experience who truly thinks in a holistic way. This was an AMAZING conversation and one not to miss! From the clinical to the spiritual, it has it all.

Advertisers: Grab a ONE MINUTE SPOT on the podcast:Email Chanalesings@gmail.com or WhatsApp for details:https://wa.link/efqjihHave an opinion you want to share?Leave me a voicenote on SpeakPipe!No app needed. Tap and Record.Join The Weekly Squeeze WhatsApp Chathttps://chat.whatsapp.com/I7fhs9clBTi3Vc9SJv2yxUMenachem Weinrab's art

THE BOOK FOR EVERYONE'S COFFEE TABLE This is where artist and Creative Director at Mishpacha Magazine @Menachem Weinreb would like to see his new book “Mystical Matters of the Bible and Beyond” as you'll hear in his 613 Books Podcast interview with host Heather Dean. This is your very own preview of Heather's pick for what she predicts will be the next big thing in Jewish books. If you are ready to experience a book that readers of all ages, backgrounds and levels of Talmudic scholarship can enjoy, check out this interview for a fresh read. Show Notes: Featured Guest: Menachem Weinreb, Creative Director, Mishpacha Magazine The Next Big Thing in Jewish Books: "Mystical Matters of the Bible and Beyond” Kickstarter link: https://www.amudart.com/coming-soon-02 Contact Menachem either through his website: Amudart.com, or email: contact@amudart.com Instagram handles: @meweinreb, and @amudart Show Announcer for 613 Books Podcast: Michael Doniger Michael's contact info, voice-over samples, and demo: michaeldoniger.com/

Today, my guest is Maya Weinreb Maya is an entrepreneur and a real estate investment bookkeeping specialist. Maya's been doing bookkeeping for almost 20 years, and is a QuickBooks Pro advisor. Before she started her bookkeeping firm, she held the position of CFO for a marketing company in Los Angeles. And in just a minute, we're going to speak with Maya about what does every real estate investor need for their books.

J Darrin Gross I'd like to ask you, Maya Weinreb, What is the Biggest Risk?   Maya Weinreb   Yes, I thought about this, I thought about this. I think the biggest risk right now, for real estate investors, for clients, for entrepreneurs, for individuals, for everybody right now, is the fact that the IRS just hired 87,000 new auditors. And you know, we saw articles about that a lot at the end of last year. And I don't know if they're all hired, and they're all implemented. But what does that mean to an individual? What does that mean to an investor? That means that they're, they're 87,000 times more likely to get audited, at least not saying I'm a mathematician, so maybe me No, that's not the exact math, you math it. But to me, that's 87,000 More people who could potentially go and audit your business, your investments. So it just makes it so that all of the things that you're supposed to do that you kind of said, well, no one's ever audited me and it's never really been a big deal. Now is the time to get all of your ducks in a row. Because you are have to map it correctly. Let's just say there's 87,000 More people who could try to audit you than there were before those 87,000 more resources to do that, because the IRS doesn't have time to deal with all of our stuff. Right? They're they're busy going after big fish. And we know ways. You know, there's many tax strategies to minimize risk to not look like you have a bunch of red flags that might get audited, and that's great. So we want to keep doing all those things. For instance, if you have an S corp To make sure you have payroll, that's the biggest red flag, you know, a lot of real estate investors aren't S corporations, their LLC, and so it's different. But sometimes they have holding companies that are s corpse, things like that. And if the IRS audits, you, they're gonna want to see your books, they're gonna want to see receipts for everything, they're gonna want to see bank statements. And on things like business meals, or whatever, that a lot of people not gonna say, a lot of people, some people every time they go to dinner, or have dinner by themselves will consider it a business expense. And the IRS is gonna want you to prove that it was a business expense, and who you went to dinner with. And that needs to be, you know, written on the receipt or in your books for it to make sense, your 1099 that you're like, Well, I'm not going to turn 99, the plumber because it's never really been that big of a deal. It might start being a big deal. There's there are rules written into the IRS code of what happens if you don't file a 1099 on someone, and you allow you know them to work for you under the table. And it's not that big a deal. There's rules and there's big penalties, there's penalties for filing a late 1099, there's penalties on not filing a 1099. And they have not that I know of to this day actually implemented those penalties because they haven't really had time to deal with all of the 1099 filing, for instance, as an example. But now they have 87,000 More people who might be taking a look at that. And in the IRS being the IRS, if they find something that you did wrong, they might try to go backwards and audit you the last seven years. So now is really the time to make sure that we have all our ducks in a row, that we're using the same tax return to get our investments that we use to file with the IRS that we are filing our 1090 nines on every single person that's a service provider, that we have detailed receipts on everything. And I think that while I hope that we can continue, you know, just being risk averse, and and not creating things that are red flags, I don't know that that's the case anymore, that might be changing. They might be you know, I'm really trying not to swear, they might be getting harder on us. And so in order to avoid risk to mitigate risk to minimize risk, you got to have all your legal bookkeeping, IRS ducks in a row. And I don't mean to say that there's some big monster that's terrible and scary, because they're not. And they're all you know, pretty much all IRS agents and auditors are nice people and they're helpful and they're just doing their job. And it's not to say don't go make money or go hide in a corner, you know, make money, they can't talk to you. If you're not making money, go do something, you know, go go buy that property, go do that cool thing you're doing. But just have all your ducks in a row so that nothing can ever come back and build, you know, tear down your empire that you built.  

The race to address climate change is creating a whole lot of opportunity and a whole lot of work. Just to offer a sense of the scale, the US Inflation Reduction Act is expected to create nine million jobs alone. This is on top of an already booming climate job market. And, climate isn't just tackled through newly created jobs, but also through new climate responsibilities within existing jobs. To learn more about the world of climate work, I sat down with two experts: Peggy Brannigan and Ellen Weinreb. Peggy is the Director of Global Environmental Sustainability at LinkedIn, where she has access to perhaps the world's best database of climate-related jobs. Ellen is the founder of Weinreb Group, a recruiting firm that has been focused on filling sustainability and ESG roles for over 10 years. Together, Peggy and Ellen provide a fascinating glimpse into the green job market, how it's evolved in recent years, the skills that are most needed, and of course, advice for hiring teams and jobseekers. So whether you're looking for a job, looking to hire people, or just trying to anticipate the skills you'll need for the future, this episode should be helpful to you. Enjoy. In today's episode, we cover:[3:20] Ellen's role & journey into sustainability work[4:27] Peggy's role & journey into sustainability work[5:26] LinkedIn's economic graph - the data used & the value it brings[7:45] The climate job market - how has it changed & what does it look like today[9:01] The roles that companies are looking for[10:46] Geographies & drivers of climate job growth [12:48] What is ESG & how is it different from sustainability[14:26] The evolution of the job market for ESG & sustainability leaders over 15 years[16:45] Corporate commitments to hiring ESG professionals [19:33] The most sought-after skills for climate work today [21:57] The prediction that half of all jobs will be redefined by climate change[23:04] Advice for companies seeking to grow their ESG & sustainability teams[27:15] Peggy's advice for climate jobseekers[30:32] Being a changemaker within both existing & new companies[32:48] Ellen's advice for climate jobseekers[33:48] The future of the climate job marketResources MentionedLinkedInWeinreb GroupLinkedIn Economic Graph: Global Green Skills Report 2022Greenbiz x Weinreb: State of the Profession 2022 ReportReuters: PwC planning to hire 100,000 over five years in major ESG push LinkedIn: Green JobsConnect with Peggy Brannigan & Ellen WeinrebConnect with Peggy on LinkedInConnect with Ellen on

Parenting always has inevitable bumps in the road, but when you are a parent of a special needs child, those numerous bumps can feel even more aggravated by bureaucracy, systematic educational insufficiency, and, hardest of all, burn-out of all sorts. This is what mother Kim Weinreb discovered when her son was diagnosed with a pre-natal stroke while in the womb, and the subsequent difficulties of his developmental delays and a social system, frankly, not set up to easily assist his needs. Now, as her son is transitioning into an adapted adult life, she is sharing her experience and well-earned expertise with other parents of special needs children of all ages. Recently she founded Transitionally Speaking, a counseling service to help guardians navigate the transition from child to adult services and support. She joins this episode of Relentlessly Resilient to share her experiences, brag about her son's accomplishments, and encourage others in similar situations to advocate for disability rights, navigate red tape, and, importantly, seek help and self-care.  Even though we live in challenging times, we can become Relentlessly Resilient as we lean on and learn from one another's experiences. Hosts Jennie Taylor and Michelle Scharf are no strangers to overcoming adversity; Michelle lost her husband to cancer, while Jennie's husband, Major Brent Taylor, was killed in the service of our country. Their stories bond them together, and now listeners can join them weekly as they visit with others enduring challenges and who teach us how they are exercising resiliency, finding value in their grief, and purpose in moving forward.  Listen to the Relentlessly Resilient Podcast regularly on your favorite platform, at kslpodcasts.com, kslnewsradio.com, or on the KSL NewsRadio App Join the Resilience conversation on Facebook at @RelentlesslyResilient and Instagram @RelentlesslyResilientPodcast. Produced by KellieAnn Halvorsen.See omnystudio.com/listener for privacy information.

Maya has been doing bookkeeping for almost 20 years and is a QuickBooks Proadvisor. Before she started her Bookkeeping firm, she held the position of CFO for a marketing company in Los Angeles. After starting Solvency Now Bookkeeping in 2018, her company has grown to a team of 10 and provides bookkeeping services to almost 150 companies. Solvency Now is a boutique bookkeeping firm with concierge level service. Solvency Now Bookkeeping's mission statement is, ""Complete and perfect financial records for Business Owners' peace of mind"". She has personally done books for hundreds of companies and now consults business owners on financial planning and bookkeeping. Her purpose is to help business owners succeed. Find out more about Maya at: Website: https://www.solvencynow.com/ LinkedIn: https://www.linkedin.com/in/maya-weinreb-05012b4b/ Facebook: https://www.facebook.com/solvencynow Instagram: https://www.instagram.com/solvencynow_bookkeeping/   Check out our YouTube Channel: Jeremyryanslatebiz See the Show Notes: www.jeremyryanslate.com/1055 Unremarkable to Extraordinary: Ignite Your Passion to Go From Passive Observer to Creator of Your Own Life: https://getextraordinarybook.com/

Maya has been doing bookkeeping for almost 20 years and is a QuickBooks Proadvisor. Before she started her Bookkeeping firm, she held the position of CFO for a marketing company in Los Angeles. After starting Solvency Now Bookkeeping in 2018, her company has grown to a team of 10 and provides bookkeeping services to almost 150 companies. Solvency Now is a boutique bookkeeping firm with concierge level service. Solvency Now Bookkeeping's mission statement is, ""Complete and perfect financial records for Business Owners' peace of mind"". She has personally done books for hundreds of companies and now consults business owners on financial planning and bookkeeping. Her purpose is to help business owners succeed. Find out more about Maya at: Website: https://www.solvencynow.com/ LinkedIn: https://www.linkedin.com/in/maya-weinreb-05012b4b/ Facebook: https://www.facebook.com/solvencynow Instagram: https://www.instagram.com/solvencynow_bookkeeping/   Check out our YouTube Channel: Jeremyryanslatebiz See the Show Notes: www.jeremyryanslate.com/1055 Unremarkable to Extraordinary: Ignite Your Passion to Go From Passive Observer to Creator of Your Own Life: https://getextraordinarybook.com/

In this episode, we are going to talk about End of Year Bookkeeping and Tax Prep. We sit down with Maya Weinreb, founder of Solvency Now Bookkeeping, to discuss the most important thing you can do RIGHT NOW to get your books ready for tax season and common bookkeeping issues people make in real estate investing. Because if you are anything like me, you would rather keep what you worked for rather than give it away to the tax machine in D.C.    5:08 - Advice for 2023 Taxes 10:39 - Why your bookkeeper and CPA should meet together 17:58 - Making sure your business structure is correct for taxes 20:46 - Budget vs. Financial Planning  25:37 - How to get in front of your tax problems 31:00 - Tax Loopholes and offset 33:40 - 1099 Taxes “If you don't have bookkeeping, one, I don't know how you manage your company [but some people do], but two, there's nothing else that you can do without having that.” About Robnett's Real Estate Run Down With over 27 years in the real estate industry, Shannon shares actionable advice on wholesaling, fix and flips, single-family, multi-family, and more. Hear real people talk about all facets of the market, including analysis, challenges, management, and investment successes. Every conversation provides the foundation for a thriving career. Guest Bio: Maya Weinreb Maya started Solvency Now Bookkeeping 5 years ago with the mission to provide perfect and complete financial records which results in the business owner's peace of mind. They do full-service bookkeeping, meaning AP, AR, payroll, payroll taxes, sales tax, 1099's, tracking financial transactions, and anything a business owner needs to handle their company finances. They also partner with CPAs and tax preparers so that their clients are covered in those areas.   Website - https://solvencynow.com  FB - https://www.facebook.com/solvencynow  Insta - https://www.instagram.com/solvencynow_bookkeeping  YouTube - https://www.youtube.com/channel/UCrddILpwqG96-BECYqIQ0-g  Company LinkedIn - https://www.linkedin.com/company/solvency-now-bookkeeping 

This CME/CE activity, hosted by Ozlem Goker-Alpan, MD, Co-founder and PresidentLysosomal & Rare Disorders Research & Treatment Center (LDRTC) and Neal J Weinreb, MD, FACP, Voluntary Associate Professor of Human Genetics, University of Miami Miller School of Medicine, highlights how enzyme replacement therapies (ERTs) and substrate reduction therapies (SRTs) for lysosomal storage disorders have transformed, and will continue to transform, the treatment landscape for these rare conditions.At the end of this activity, participants should be able to:• Describe how ERTs/SRTs have transformed the LSD population• Describe the new research underway to improve safety and efficacy of ERTs/SRTs• Describe how ERTs/SRTs are addressing the problem of the blood brain barrierEducational Support for this activity was provided by Takeda, Sanofi, and Cheisi.To obtain CME credit, please visit https://checkrare.com/learning-center/courses/

In this episode of the Epigenetics Podcast, we caught up with Nada Jabado from McGill University to talk about her work on oncohistones as drivers of Pediatric Brain Tumors. Nada Jabado and her team were amongst the first to identify mutations in Histone 3.3 Tails which lead to differentially remodeled chromatin in pediatric glioblastoma. Mutations that occur include the Lysine at position 27 and the Glycine at position 34. If those residues are mutated it will influence the equilibrium of chromatin associated proteins like the Polycomb Repressive Complex (PRC) and hence domains of heterochromatin will be shifted. This, in turn, will lead to differential gene expression and development of developmental disorders or cancer.   References Schwartzentruber, J., Korshunov, A., Liu, X. Y., Jones, D. T., Pfaff, E., Jacob, K., Sturm, D., Fontebasso, A. M., Quang, D. A., Tönjes, M., Hovestadt, V., Albrecht, S., Kool, M., Nantel, A., Konermann, C., Lindroth, A., Jäger, N., Rausch, T., Ryzhova, M., Korbel, J. O., … Jabado, N. (2012). Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma. Nature, 482(7384), 226–231. https://doi.org/10.1038/nature10833 Kleinman, C. L., Gerges, N., Papillon-Cavanagh, S., Sin-Chan, P., Pramatarova, A., Quang, D. A., Adoue, V., Busche, S., Caron, M., Djambazian, H., Bemmo, A., Fontebasso, A. M., Spence, T., Schwartzentruber, J., Albrecht, S., Hauser, P., Garami, M., Klekner, A., Bognar, L., Montes, J. L., … Jabado, N. (2014). Fusion of TTYH1 with the C19MC microRNA cluster drives expression of a brain-specific DNMT3B isoform in the embryonal brain tumor ETMR. Nature genetics, 46(1), 39–44. https://doi.org/10.1038/ng.2849 Papillon-Cavanagh, S., Lu, C., Gayden, T., Mikael, L. G., Bechet, D., Karamboulas, C., Ailles, L., Karamchandani, J., Marchione, D. M., Garcia, B. A., Weinreb, I., Goldstein, D., Lewis, P. W., Dancu, O. M., Dhaliwal, S., Stecho, W., Howlett, C. J., Mymryk, J. S., Barrett, J. W., Nichols, A. C., … Jabado, N. (2017). Impaired H3K36 methylation defines a subset of head and neck squamous cell carcinomas. Nature genetics, 49(2), 180–185. https://doi.org/10.1038/ng.3757 Chen, C., Deshmukh, S., Jessa, S., Hadjadj, D., Lisi, V., Andrade, A. F., Faury, D., Jawhar, W., Dali, R., Suzuki, H., Pathania, M., A, D., Dubois, F., Woodward, E., Hébert, S., Coutelier, M., Karamchandani, J., Albrecht, S., Brandner, S., De Jay, N., … Jabado, N. (2020). Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA for Gliomagenesis. Cell, 183(6), 1617–1633.e22. https://doi.org/10.1016/j.cell.2020.11.012 Chaouch, A., Berlandi, J., Chen, C., Frey, F., Badini, S., Harutyunyan, A. S., Chen, X., Krug, B., Hébert, S., Jeibmann, A., Lu, C., Kleinman, C. L., Hasselblatt, M., Lasko, P., Shirinian, M., & Jabado, N. (2021). Histone H3.3 K27M and K36M mutations de-repress transposable elements through perturbation of antagonistic chromatin marks. Molecular cell, 81(23), 4876–4890.e7. https://doi.org/10.1016/j.molcel.2021.10.008   Related Episodes Cancer and Epigenetics (David Jones) Epigenetics & Glioblastoma: New Approaches to Treat Brain Cancer (Lucy Stead) Targeting COMPASS to Cure Childhood Leukemia (Ali Shilatifard)   Contact Active Motif on Twitter Epigenetics Podcast on Twitter Active Motif on LinkedIn Active Motif on Facebook Email: podcast@activemotif.com

Rabbi Binyomin Weinreb on Let's Get Real with Coach Menachem Sunday, May 8, 2022, Episode # 101 The 3 Keys to Stay Connected as We Mature, How to remain Passionate about Yiddishkeit after leaving Yeshivah and Seminary --- Support this podcast: https://anchor.fm/menachem-bernfeld/support