POPULARITY
At the end of October, the ONS announced that the fertility rate in England and Wales had fallen to 1.44 births per woman in 2023 - the lowest figure since records began in 1938. What will this mean for the population make-up of the country? What other big demographic shifts are occurring? Why is this trend occurring across the developed world? And what will its implications be for the public finances?To discuss those questions, Paul is joined by Melinda Mills, Director of the Leverhulme Centre for Demographic Science and Nuffield Professor of Demography at Oxford. And by Carl Emmerson, Deputy Director at IFS and one of the leading experts on the UK's public finances.Become a member: https://ifs.org.uk/individual-membershipFind out more: https://ifs.org.uk/podcasts-explainers-and-calculators/podcasts Hosted on Acast. See acast.com/privacy for more information.
Derek Hockaday interviews Pierre Foex, Emeritus Nuffield Professor of Anaesthetics, 21 November 2018. Topics include: (00:00:12) coming to Oxford initially in 1970; (00:03:50) respiration unit at Churchill and the Radcliffe Infirmary; (00:05:20) Guillain-Barre and first case treated by temporary pace maker; (00:07:23) Dphil thesis on effect of carbon-dioxide on the heart and circulation; (00:10:38) research into beta blockers and anaesthesia; (00:13:00) relationship with the university; (00:16:07) teaching clinical students; (00:19:08) the Pain Clinic; (00:22:01) anaesthetic Dphil students; (00:26:07) moving from lecturer to professor to retired professor and university changes such as the Nuffield Benefaction including the field of grants; (00:31:20) relationships with surgeons, and memories of collaboration with Peter Morris as Nuffield Professor of Surgery; (00:40:51) working with the nurses and importance of nurses; (00:44:56) changes in fluid balance management throughout career; (00:49:07) differences in nursing between Geneva and Oxford; (00:50:50) balancing writing, lecturing, working and being involved on national scene as member of Council of the College of Anaesthetists and representative on the Oxford Radcliffe Trust Board; (01:00:24) interactions with Oxford relating to NHS university department; (01:05:30) comments on being in Oxford during first rate developments, impact of the Oxford Centre for Simulation at the John Radcliffe; (01:15:11) use of exercise electrocardiograms ECGs. Note the following sections of audio are redacted: 00:23:31-00:24:39, 00:55:42-00:56:19; 00:58:05-01:00:24.
Professor Robert Sanders, Nuffield Professor of Anaesthesia at Sydney University joins Dr Ron Glick and Dr Alan Peirce to discuss the NEUROVISION study (Lancet, 2019) and its relevance to anaesthetic practice, and current and future directions of research in perioperative cognitive dysfunction.
The increased reliance of health systems on the digital record as the primary mechanism for storing data on consultations and other health interactions has opened new opportunities for research, healthcare innovation, and health policy. The electronic health record (eHR) is now ubiquitous in many countries, in hospital and primary care settings, and in some countries their health systems in terms of reporting patient care activity are essentially 'paperless'. Health systems globally are also facing accelerating challenges as they seek to deliver better value healthcare against the background of increasing levels of chronic disease, ageing populations, financial pressures and demands on public spending. Digital health tools and services are held up to be part of the solution to these challenges, potentially offering low-cost and patient-centred solutions. There has been huge investment in Big Data research in health, particularly in relation to digitised imaging and automated reporting and predictive modelling using phenotypic and increasingly genetic data. There have also been similar gains in more applied research that explores the potential of accessing the huge quantum of data held in the eHR, and linkage of these data to other national or regional databases, such as mortality records or cancer data. This session will explore some of the applications for routine data research, illustrated by projects that have resulted in research success and better healthcare. This will include the exemplars of using large eHR platforms and prescribing data platforms to create infrastructure for i) common disease surveillance, such as the UK RCGP RSC; ii) generation and validation of disease risk assessment tools, such as QRisk scores; iii) pragmatic electronic follow up trials; iv) within practice systems dashboard feedback reports, eg data normalised to regional and national rates on prescribing and investigation physician activity; v) traditional epidemiological linkage studies; and vi) linkage to long term phenotypic follow up of established disease cohorts. Richard Hobbs is Nuffield Professor of Primary Care at the University of Oxford, and Head of the Nuffield Department of Primary Care Health Sciences. He has served a decade as National Director of the National Institute for Health Research's School for Primary Care Research and was Director of the NHS Quality and Outcomes Framework (QOF) Review panel from 2005-09. He has served many national and international scientific and research funding boards in UK, Ireland, Canada, and WHO, including the BHF Council, British Primary Care Cardiovascular Society, and the ESC Council for Cardiovascular Primary Care. He currently chairs the European Primary Care Cardiovascular Society, a WONCA Special Interest Group. He is one of the world's leading academics in primary care, and has developed at Oxford one of the largest and most highly ranked centres for academic primary care globally. He has also made major contributions to growing primary care academic capacity, in terms of people development and research networks. A highly cited primary care clinical scientist, he has authored over 450 peer reviewed publications, has an h-index of 90, with over 63000 citations (36000 since 2013) and 81 papers cited over 100 times, 14 papers cited over 1000 times and 7 papers with over 2000 citations. He has an outstanding track record in cardiovascular research, delivering trials that changed international guidelines and practice, especially in the areas of stroke prevention in atrial fibrillation (BAFTA, SAFE, and SMART trials), heart failure burden and diagnosis (ECHOES and REFER trials), and hypertension self-management (TASMINH series). He is only the fifth ever recipient of the RCGP Discovery Prize in 2018 (an occasional award made since 1953) and received an inaugural Distinguished Researcher Shine Prize plus Best Presentation Prize at the WONCA World Congress in 2018. He was awarded a CBE for services to medical research in the 2018 New Year's Honours. This talk was held as part of the Big Data Epidemiology course which is part of the Evidence-Based Health Care Programme.
The increased reliance of health systems on the digital record as the primary mechanism for storing data on consultations and other health interactions has opened new opportunities for research, healthcare innovation, and health policy. The electronic health record (eHR) is now ubiquitous in many countries, in hospital and primary care settings, and in some countries their health systems in terms of reporting patient care activity are essentially 'paperless'. Health systems globally are also facing accelerating challenges as they seek to deliver better value healthcare against the background of increasing levels of chronic disease, ageing populations, financial pressures and demands on public spending. Digital health tools and services are held up to be part of the solution to these challenges, potentially offering low-cost and patient-centred solutions. There has been huge investment in Big Data research in health, particularly in relation to digitised imaging and automated reporting and predictive modelling using phenotypic and increasingly genetic data. There have also been similar gains in more applied research that explores the potential of accessing the huge quantum of data held in the eHR, and linkage of these data to other national or regional databases, such as mortality records or cancer data. This session will explore some of the applications for routine data research, illustrated by projects that have resulted in research success and better healthcare. This will include the exemplars of using large eHR platforms and prescribing data platforms to create infrastructure for i) common disease surveillance, such as the UK RCGP RSC; ii) generation and validation of disease risk assessment tools, such as QRisk scores; iii) pragmatic electronic follow up trials; iv) within practice systems dashboard feedback reports, eg data normalised to regional and national rates on prescribing and investigation physician activity; v) traditional epidemiological linkage studies; and vi) linkage to long term phenotypic follow up of established disease cohorts. Richard Hobbs is Nuffield Professor of Primary Care at the University of Oxford, and Head of the Nuffield Department of Primary Care Health Sciences. He has served a decade as National Director of the National Institute for Health Research’s School for Primary Care Research and was Director of the NHS Quality and Outcomes Framework (QOF) Review panel from 2005-09. He has served many national and international scientific and research funding boards in UK, Ireland, Canada, and WHO, including the BHF Council, British Primary Care Cardiovascular Society, and the ESC Council for Cardiovascular Primary Care. He currently chairs the European Primary Care Cardiovascular Society, a WONCA Special Interest Group. He is one of the world's leading academics in primary care, and has developed at Oxford one of the largest and most highly ranked centres for academic primary care globally. He has also made major contributions to growing primary care academic capacity, in terms of people development and research networks. A highly cited primary care clinical scientist, he has authored over 450 peer reviewed publications, has an h-index of 90, with over 63000 citations (36000 since 2013) and 81 papers cited over 100 times, 14 papers cited over 1000 times and 7 papers with over 2000 citations. He has an outstanding track record in cardiovascular research, delivering trials that changed international guidelines and practice, especially in the areas of stroke prevention in atrial fibrillation (BAFTA, SAFE, and SMART trials), heart failure burden and diagnosis (ECHOES and REFER trials), and hypertension self-management (TASMINH series). He is only the fifth ever recipient of the RCGP Discovery Prize in 2018 (an occasional award made since 1953) and received an inaugural Distinguished Researcher Shine Prize plus Best Presentation Prize at the WONCA World Congress in 2018. He was awarded a CBE for services to medical research in the 2018 New Year's Honours. This talk was held as part of the Big Data Epidemiology course which is part of the Evidence-Based Health Care Programme.
Pain, as we know, is highly personal. Some can cope with huge amounts, while others reel in agony over a seemingly minor injury. Though you might feel the stab of pain in your stubbed toe or sprained ankle, it is actually processed in the brain. That is where Irene Tracey, Nuffield Professor of Anaesthetic Science at Oxford University, has been focussing her attention. Known as the Queen of Pain, she has spent the past two decades unravelling the complexities of this puzzling sensation. She goes behind the scenes, as it were, of what happens when we feel pain - scanning the brains of her research subjects while subjecting them to a fair amount of burning, prodding and poking. Her work is transforming our understanding, revealing how our emotions influence our experience of pain, how chronic pain develops and even when consciousness is present in the brain. Producer: Beth Eastwood
Pain, as we know, is highly personal. Some can cope with huge amounts, while others reel in agony over a seemingly minor injury. Though you might feel the stab of pain in your stubbed toe or sprained ankle, it is actually processed in the brain. That is where Irene Tracey, Nuffield Professor of Anaesthetic Science at Oxford University, has been focussing her attention. Known as the Queen of Pain, she has spent the past two decades unravelling the complexities of this puzzling sensation. She goes behind the scenes, as it were, of what happens when we feel pain - scanning the brains of her research subjects while subjecting them to a fair amount of burning, prodding and poking. Her work is transforming our understanding, revealing how our emotions influence our experience of pain, how chronic pain develops and even when consciousness is present in the brain. Producer: Beth Eastwood
The Western feud over “nature vs. nurture” dates back at least to an essay by John Locke in 1690. The idea that it’s an absolute binary – that our actions are determined solely by one or the other – is thankfully passé. And yet, in an academic setting, with scholars safe in their silos, the tension continues in practice if not in conversation. For a bit of anecdotal evidence, look at Melinda Mills, the head of department and Nuffield Professor of Sociology at Oxford University. She studied the sociology and demography of families and family formation – things like when to choose to have a child, what a women’s age is when she first gives birth, or the number of children someone might have. “I was,” she tells interviewer David Edmonds in this Social Science Bites podcast, “looking at them in a very socially deterministic way. I was looking at things such as childcare institutions or gender equality or the kind of jobs that women and men have, and was childcare available and affordable and ... I was using those as explanations and predictors. “And then I met some biologists and geneticists.” Over drinks that day, these fellow researchers made fun of Mills: “This is Melinda and she studies fertility, but she doesn’t think it has any biological basis.” Much hilarity ensued. But the gibes bore a pleasant fruit – Mills broke free of the limits on her scholarship with which she had shackled herself. Her studies and collaborations now combined social science and molecular genetics; she now studies ‘sociogenomics,’ with a particular emphasis on how these interplay in the areas of inequality and life course. In that vein, she is the principal investigator of the SOCIOGENOME project and the ESRC National Centre for Research Methods SOCGEN project. She notes that each part of the triad – social scientists, biologists and geneticists bring their real science to the table. “Wellbeing, depression, reproductive choice – [social scientist] are very good at measuring that. We then work with biologists and geneticists, who determine genetic loci, and then with biologists, who determine the biological function of those genes. “As social scientists, we then create a score, your ‘reproductive score,’ and we add those to our statistical models together with the social science variables -- the usual suspects lie your family background or your partner or educational level – and we add those together with the genetic data and we look at the interaction between those.” And, as you’ll learn, there can be surprises for all concerned. Geneticists, for example, might assume that genetic loci are universal ... but are they? The effort also harnesses the big data of genetics technology, tapping into databases like the UK Bio Bank or the direct-to-consumer testing services like 23andMe. In addition to her sociogenomics projects, Mills is a leader of the Working Package on Childlessness and Assisted Reproductive Technology in the European Families And Societies network, editor-in-chief of the European Sociological Review, and a fellow of the European Academy of Sociology.
In this short talk, Professor Melinda Mills introduces her work on the role of gene and gene-environment interaction on reproductive health Sociogenome is comprehensive study of the role of genes and gene-environment (GxE) interaction on reproductive behaviour. Until now, social science research has focussed on socio-environmental explanations, largely neglecting the role of genes. Drawing from recent unprecedented advances in molecular genetics in this talk Professor Melinda Mills, principal investigator of the Sociogenome project examines whether there is a genetic component to reproductive outcomes, including age at first birth, number of children and infertility and their interaction with the social environment. Melinda Mills (PhD Demography) is the Nuffield Professor of Sociology. Her main research areas are currently in the area of sociogenomics (combing a social science and molecular genetic approach to the study of behavioural outcomes), with a focus on life course, fertility, partnerships and assortative mating. She joined the University of Oxford in 2014 and was previously at the University of Groningen and Free University Amsterdam, The Netherlands and the University of Bielefeld, Germany. She is currently the Head of the Department of Sociology, Editor-in-Chief of the European Sociological Review, Fellow of the European Academy of Sociology, and an ESRC Executive Council Member.
Sir Peter Morris, Nuffield Professor of Surgery at Oxford University and President of the Royal College of Surgeons: “Life on a Knife’s Edge”
Professor Freddie Hamdy is Nuffield Professor of Surgery at Oxford University. He talks about prostate cancer screening, diagnosis and treatment.
The historian Conrad Keating continues his history of Oxford's groundbreaking contribution to health in the tropics by asking David Warrell what motivated him to work in Africa... The modern history of Oxford's medical contribution to the great neglected diseases of mankind begins with David Warrell's appointment as Director of the Mahidol-Oxford-Wellcome Unit in Bangkok, Thailand in May, 1979. Tropical research had fascinated Warrell since his time working in Nigeria and Addis Ababa in 1968. Together with his wife Mary, a medical virologist, he was chosen by David Weatherall, the Nuffield Professor of Medicine, to be Oxford's first practitioner of "medicine in the tropics" and he set himself the task of researching the patho-physiology of diseases. Jettisoning a safe, if uninspiring career as a consultant physician at the Radcliffe Infirmary, and supported by a Wellcome grant, he began research on cerebral malaria and the intradermal application of rabies vaccines. Although David Weatherall was unsure as to the Unit's longevity, his initial scepticism was soon dispelled: "David Warrell did an extremely fine job in setting up the unit and I was extremely proud of them all when I saw one of the first papers, the New England Journal of Medicine piece on the positive harm that can be done by treating cerebral malaria with steroids and the advice for its better management; what a wonderful start!" As well as becoming a world authority on snake bites, David Warrell laid the foundations for scientific excellence that Nick White and Nick Day have built upon so successfully in recent years. It was undoubtedly the enormous success of the Bangkok unit that has given rise to the other outstanding units based in Oxford, Vietnam, Laos and Kenya.
Conrad Keating, the medical historian, opens his series with an interview with Sir David Weatherall to mark World Malaria Day on April 25th 2010. Sir David was appointed Nuffield Professor of Clinical Medicine in 1974, and in 1989 he founded the Institute of Molecular Medicine (in 2000 it was renamed The Weatherall Institute of Molecular Medicine). Sir David tells the story of the evolution of tropical medicine in Oxford from its inception in the late 1970s to its unrivaled standing in the developing world today.