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In this episode of the RWS Clinician's Corner, Margaret Floyd Barry takes us behind the scenes into the dynamic world of research and curriculum development in the functional health space. Margaret sits down with two of Restorative Wellness Solutions' powerhouse instructors, Ellen Lovelace and Paige Reagan, for a candid conversation about the challenges, surprises, and daily realities of translating emerging science into practical, safe, and effective tools for clinicians. In this interview, we discuss: -Specific ways that Ellen & Paige demonstrate curriculum leadership and research support for RWS -How to respond to new studies or challenges to existing curriculum -How to decide which sources to trust -How to evaluate clinical research (red & green flags) -Addressing research limitations and gaps -Using research tools and AI in gathering evidence The Clinician's Corner is brought to you by Restorative Wellness Solutions. Follow us: https://www.instagram.com/restorativewellnesssolutions/ Connect with Ellen: Website: www.abalancedtable.net Facebook: www.facebook.com/abalancedtable Instagram: www.instagram.com/abalancedtable Connect with Paige: Website: www.naturallynourishedwellness.com Instagram: www.instagram.com/paigereaganntp Timestamps: 00:00 From Russian Studies to Health Advocacy 07:56 Curriculum Accuracy and Depth Focus 12:57 Using AI for Study Validation 19:20 Evaluating Research Article Credibility 25:24 Animal Study Relevance and Limitations 28:03 "Pediatric Research Gaps in Drug Trials" 33:55 "Teaching Deepens Understanding" 41:17 Questioning AI for Balanced Answers 44:47 Effective Research Strategies and AI Limitations 52:04 Verify Before Believing Headlines 55:52 "Unpaywall: Access Free Academic Papers" 01:00:33 "The Clinician's Corner Podcast" Speaker bios: Ellen Lovelace, Lead Instructor & Curriculum Development Master RHP, MPH, FNTP, Board Certified in Holistic Nutrition® Ellen (she/her) has been actively working to educate and improve the public's health for almost 20 years. Ellen received her Masters in Public Health from The George Washington University, and went on to run everything from tuberculosis prevention programs in Russia to dental health education programs along the Texas/Mexico border. She was also the founding Executive Director of the women's health program at Stanford University. When Ellen became drawn to a more holistic model, she received her certifications as a Nutritional Therapy Consultant and a Master Restorative Health Practitioner. She is the owner of A Balanced Table Nutritional Therapy in San Jose, CA, her private functional nutrition practice. Ellen focuses on cutting through the confusion and nutrition “noise,” digging to the roots of clients' dysfunction, and figuring out the best way for them to eat, drink, and thrive. She uses the IRH functional analysis tools daily, and is excited to share her passion for these methods. Ellen believes that only by focusing on root causes, combined with whole foods nutrition, can true wellness be achieved. Ellen is also a passionate animal lover who volunteers at a wildlife rescue facility, and can often be found smelling of skunk while covered in Mastiff drool. Paige Reagan, Instructor and Research Master RHP, FNTP Paige has spent most of her career working in Research and Development in the areas of clinical research, regulatory affairs, and medical writing. She has a wide range of experience in the therapeutic areas of cardiovascular health, pulmonary arterial hypertension, diabetes, bone health, osteoarthritis/rheumatoid arthritis, and urology, among others. Her work has contributed to numerous regulatory approvals as well as publications in major medical journals such as the New England Journal of Medicine, Lancet, Circulation, and American Heart Journal. Paige has since earned certifications as a Functional Nutritional Therapy Practitioner and Master Restorative Health Practitioner. She is owner of Naturally Nourished Wellness, a small practice specializing in gut health and the downstream effects of poor digestion. She strives to find balance between the holistic and mainstream approaches and aims to provide her clients with the best of both worlds, using her critical thinking skills from years in research combined with objective laboratory testing and her passion for the restorative power of whole foods and simple lifestyles. She spends her free time exploring the outdoors with her family, swinging kettlebells, and creating baked goods with healthier ingredients. Keywords: functional nutrition, public health, research process, curriculum development, clinical research, regulatory affairs, medical writing, gastrointestinal healing, lab testing, food sensitivities, evidence-based practice, study design, randomized controlled trials, observational studies, animal studies, peer review, PubMed, Google Scholar, AI tools in research, ChatGPT, consensus, study citations, clinical anecdote, sample size, funding bias, meta-analysis, systematic reviews, biostatistics, clinical protocols, dietary supplements Disclaimer: The views expressed in the RWS Clinician's Corner series are those of the individual speakers and interviewees, and do not necessarily reflect the views of Restorative Wellness Solutions, LLC. Restorative Wellness Solutions, LLC does not specifically endorse or approve of any of the information or opinions expressed in the RWS Clinician's Corner series. The information and opinions expressed in the RWS Clinician's Corner series are for educational purposes only and should not be construed as medical advice. If you have any medical concerns, please consult with a qualified healthcare professional. Restorative Wellness Solutions, LLC is not liable for any damages or injuries that may result from the use of the information or opinions expressed in the RWS Clinician's Corner series. By viewing or listening to this information, you agree to hold Restorative Wellness Solutions, LLC harmless from any and all claims, demands, and causes of action arising out of or in connection with your participation. Thank you for your understanding.
Send us a textLast month, The Lancet posted online an article from Stine Johansen, Fredrik Åberg, Emmanuel Tsochatzis and Aleksander Krag, titled "Screening for Advanced Liver Disease." The article aims to update the Wilson and Jungner criteria, initially developed in 1960, to address modern needs and issues. In this conversation, Professor Krag and Dr. Johansen join Roger Green to discuss their article. There are many nuances and high points to cover in this thoughtful, fairly lengthy conversation, but one key point is that screening a mass population for HCC or cirrhosis has an entirely different set of issues and criteria compared to the screening usually discussed on this podcast, which involves identifying a population at increased risk for MASLD or MASH and screening them. Also, healthcare is far more expensive than it was in 1960 with a plethora of high-cost ways to diagnose, treat and manage patients.As a result, the authors started with the 10 Wilson and Jungner criteria and added eight more. During this conversation, Stine emphasizes the need for a comprehensive clinical trial on this issue, and all panelists agree that LiverAIM is likely to serve as the study.
Inflammation is the body's natural way of healing, but when it becomes chronic and hidden, it quietly drives many of today's most common health problems—heart disease, diabetes, dementia, cancer, autoimmune conditions, and more. Unlike the redness and swelling from a cut or sprain, this “silent inflammation” often goes unnoticed while slowly damaging tissues and speeding up aging. Modern life fuels the fire: processed foods, food additives, pollution, plastics, chronic stress, too much sitting, and poor sleep. The good news is inflammation can be calmed by simple daily choices—eating colorful whole foods like berries, leafy greens, beans, nuts, seeds, and omega-3 rich fish; adding herbs and spices like turmeric and cumin; moving regularly; practicing relaxation; and repairing gut health. Even small shifts, like climbing stairs, eating within a shorter window, or reducing sugar, can make a big difference. By lowering inflammation, the body finds balance again, opening the door to more energy, resilience, and healthy aging. In this episode, I discuss, along with Dr. Shilpa Ravella and Dr. David Furman, why it's important to be aware of systemic inflammation and how to address it. Dr. Ravella is a gastroenterologist and Assistant Professor of Medicine at Columbia University Medical Center. She is the author of A Silent Fire: The Story of Inflammation, Diet & Disease, which investigates inflammation—the hidden force at the heart of modern disease. Her writing has appeared in The Atlantic, New York Magazine, The Wall Street Journal, TIME, Slate, Discover, and USA Today, among other publications. Dr. David Furman is Associate Professor and Director of the Bioinformatics Core at the Buck Institute for Research on Aging, as well as the Director of the Stanford 1000 Immunomes Project. He obtained his doctoral degree in immunology from the School of Medicine, University of Buenos Aires, Argentina, for his work on cancer immune-surveillance. During his postdoctoral training at the Stanford School of Medicine, Dr. Furman focused on the application of advanced analytics to study the aging of the immune system in humans. He has published nearly thirty scientific articles in top-tier journals such as Cell, Nature Medicine, PNAS, The Lancet, and others. This episode is brought to you by BIOptimizers. Head to bioptimizers.com/hyman and use code HYMAN to save 15%. Full-length episodes can be found here:What Causes Inflammation And How Can You Treat It? The Silent Killer: Inflammation And Chronic Disease How Silent Inflammation Accelerates Aging
durée : 00:03:24 - Va savoir - par : Chloé Leprince - Un chiffre, c'est d'abord une façon de compter. Reconnus par l'Onu mais sujets à caution ailleurs, les chiffres de l'Autorité palestinienne sont sous-estimés, explique l'historien Jean-Pierre Filiu après des conclusions analogues du Lancet : ils ne tiennent pas compte de toutes les morts indirectes.
Send us a text00:00:00 - Surf's Up: Season 6 Episode 13 Louise Campbell, Jörn Schattenberg and Roger Green continue their discussion of some major issues from earlier this year, while co-authors Aleksander Krag and Stine Johanset join Roger to discuss their recent publication in The Lancet, titled "Screening for Advanced Liver Disease." 00:04:45 - Major Issues of the First Six Months: Integrated Patient ManagementLouise drives this conversation based on two related issues she sees emerging: (i) increasing opportunities for motivated patients to manage their own health and (ii) managing the total patient in an environment where people may be taking incretin agonists as if they are consumer drugs. With increased access to scanning, providers can monitor patients (and patients can self-monitor) more closely. However, some of the issues a provider might find are tricky: patients who undertake what Louise describes as "the sneaky areas patients think are normal, but are probably contributing to disease" due to miseducation or no education on healthy eating and lifestyle, or patients purchasing and using incretin agonists through consumer channels, but possibly at subtherapeutic doses. Vigilance and probing are key here, but health systems will need to train more people on the types of probing that uncover underlying issues and behaviors that patients mistakenly believe to be healthy. 00:21:02 - Newsmakers: Aleksander Krag and Stine Johansen discuss Screening for Advanced Liver DiseaseLast month, The Lancet posted online an article from Stine Johansen, Fredrik Åberg, Emmanuel Tsochatzis and Aleksander Krag, titled "Screening for Advanced Liver Disease." The article aims to update the Wilson and Jungner criteria, originally developed in 1960, to address modern needs and issues. In this conversation, Professor Krag and Dr. Johansen join Roger Green to discuss their article. There are many nuances and high points to cover in this thoughtful, fairly lengthy conversation, but the key point is that screening a mass population for HCC or cirrhosis has an entirely different set of issues and criteria compared to the screening usually discussed on this podcast, which involves identifying a population at increased risk for MASLD or MASH and screening them. 00:54:42 - Major Issues of the First Six Months: Changes in US Health Policy and Potential for Dynamism in the In-Office Scanning Market Roger drives this conversation, focusing on two very different, yet very important issues: the first is the increasing dynamism of the in-office scanning market, with leader Echosens developing new products and services, while companies like e-Scopics, Sonic Incytes, and Mindray (Hepatus) are introducing new devices with competing profiles. Roger discusses the idea that some scanners keep all data resident in the machine, while others send it immediately to the cloud. Louise suggests that we should welcome any reliable scanning device to the market. Separately, he lists some concerns about how the Trump Administration's focus on cutting services to the poor, coupled with Robert F. Kennedy Jr.'s distrust of pharmaceuticals and mainstream health research, might limit the number of Americans with access to healthcare and the kinds of care they can access. At the end of this conversation, Roger asks Jörn and Louise what they consider major issues for the next six months.01:11:40 - Business Report and Wrap-Up
Welcome back to the Hot Topics podcast from NB Medical with Dr Neal Tucker. In this new season, we chat to Dr Simon Curtis about the upcoming Autumn 2025 Hot Topics course, then discuss three new pieces of research.First, in the Lancet, which are the best anti-hypertensives, what effect does increasing a dose actually have and how good are combinations? Second, in the NEJM, does giving all the drugs improve CKD outcomes? The case for finerenone and empagliflozin. Third, do ADHD drugs help outcomes beyond core symptoms such as accidents, suicide and crime? But can we rely on the research method used...?ReferencesLancet Antihypertensive Efficacy PaperNEJM Finerenone & EmpagliflozinReport on trends in CKDBMJ ADHD meds & prevention of complicationswww.nbmedical.com/podcast
Season Six, Episode Two of The Food Professor Podcast, presented by Caddle, blends sharp industry commentary with a fascinating guest interview. Hosts Michael LeBlanc and Dr. Sylvain Charlebois kick off with a rapid-fire news roundup before diving deep into the global lobster story with award-winning journalist and author Greg Mercer.The news segment sets the tone with big changes in consumer packaged goods. Kraft Heinz's decision to split operations sparks debate on the future of “bigger is better” corporate strategies, recalling the infamous ketchup wars and highlighting how local plants may be impacted. The hosts also explore the collapse of Yves, a once-beloved Canadian plant-based food brand, and the broader struggles facing Beyond Meat and other players in the competitive, margin-tight meat alternatives market. Meal kits return to the spotlight with fresh survey data showing usage doubling since pre-pandemic levels, despite consumer pushback over price and packaging waste. Other highlights include Canadian trade friction over canola biofuel, positive signals in Canada–India relations, and Doug Ford's controversial Crown Royal protest following Diageo's U.S. plant shift. Wrapping up, the hosts acknowledge leadership transitions at McDonald's Canada and the Retail Council of Canada.The second half welcomes Greg Mercer, investigative reporter for The Globe and Mail and author of The Lobster Trap: The Global Fight for a Seafood on the Brink. Mercer shares his journey into journalism, the painstaking work of investigative reporting, and the inspirations behind his first book. He explains how lobster evolved from a “cockroach of the sea” to a global luxury product, and why the industry now sits at a dangerous crossroads. From the collapse of Rhode Island's lobster fishery to escalating tensions between Indigenous and commercial fisheries in Nova Scotia, Mercer paints a vivid picture of an industry both lucrative and fragile. He examines the outsized role of China as a market driver, the looming threat of climate change, and the urgent need for ecological—not just economic—policy decisions to prevent history from repeating the cod fishery collapse of the 1990s. The Food Professor #podcast is presented by Caddle. About UsDr. Sylvain Charlebois is a Professor in food distribution and policy in the Faculties of Management and Agriculture at Dalhousie University in Halifax. He is also the Senior Director of the Agri-food Analytics Lab, also located at Dalhousie University. Before joining Dalhousie, he was affiliated with the University of Guelph's Arrell Food Institute, which he co-founded. Known as “The Food Professor”, his current research interest lies in the broad area of food distribution, security and safety. Google Scholar ranks him as one of the world's most cited scholars in food supply chain management, food value chains and traceability.He has authored five books on global food systems, his most recent one published in 2017 by Wiley-Blackwell entitled “Food Safety, Risk Intelligence and Benchmarking”. He has also published over 500 peer-reviewed journal articles in several academic publications. Furthermore, his research has been featured in several newspapers and media groups, including The Lancet, The Economist, the New York Times, the Boston Globe, the Wall Street Journal, Washington Post, BBC, NBC, ABC, Fox News, Foreign Affairs, the Globe & Mail, the National Post and the Toronto Star.Dr. Charlebois sits on a few company boards, and supports many organizations as a special advisor, including some publicly traded companies. Charlebois is also a member of the Scientific Council of the Business Scientific Institute, based in Luxemburg. Dr. Charlebois is a member of the Global Food Traceability Centre's Advisory Board based in Washington DC, and a member of the National Scientific Committee of the Canadian Food Inspection Agency (CFIA) in Ottawa. Michael LeBlanc is the president and founder of M.E. LeBlanc & Company Inc, a senior retail advisor, keynote speaker and now, media entrepreneur. He has been on the front lines of retail industry change for his entire career. Michael has delivered keynotes, hosted fire-side discussions and participated worldwide in thought leadership panels, most recently on the main stage in Toronto at Retail Council of Canada's Retail Marketing conference with leaders from Walmart & Google. He brings 25+ years of brand/retail/marketing & eCommerce leadership experience with Levi's, Black & Decker, Hudson's Bay, CanWest Media, Pandora Jewellery, The Shopping Channel and Retail Council of Canada to his advisory, speaking and media practice.Michael produces and hosts a network of leading retail trade podcasts, including the award-winning No.1 independent retail industry podcast in America, Remarkable Retail with his partner, Dallas-based best-selling author Steve Dennis; Canada's top retail industry podcast The Voice of Retail and Canada's top food industry and one of the top Canadian-produced management independent podcasts in the country, The Food Professor with Dr. Sylvain Charlebois from Dalhousie University in Halifax.Rethink Retail has recognized Michael as one of the top global retail experts for the fourth year in a row, Thinkers 360 has named him on of the Top 50 global thought leaders in retail, RTIH has named him a top 100 global though leader in retail technology and Coresight Research has named Michael a Retail AI Influencer. If you are a BBQ fan, you can tune into Michael's cooking show, Last Request BBQ, on YouTube, Instagram, X and yes, TikTok.Michael is available for keynote presentations helping retailers, brands and retail industry insiders explaining the current state and future of the retail industry in North America and around the world.
Vergesslichkeit im Alter – ganz normal oder ein Warnzeichen für Alzheimer? In diesem Gespräch geht Prof. Dr. Christian Sina, Facharzt für Innere Medizin und Ernährungsmediziner, mit Prof. Dr. Lars Wojtecki der Frage nach, wie sich Alzheimer von anderen Formen der Demenz unterscheidet und wie wir unser persönliches Risiko deutlich senken können. Wann ist Vergesslichkeit harmlos, wann nicht mehr? Welche Rolle spielen Ernährung, Bewegung, Schlaf und unser Blutzucker? Und was ist wirklich dran an Vitaminpräparaten, Nahrungsergänzung und neuen Antikörper-Therapien? Außerdem geht es um: • Früherkennung: Welche Tests sind sinnvoll – und welche (noch) nicht? • Die 12+2 beeinflussbaren Risikofaktoren laut Lancet Commission • Typ-2-Diabetes als möglicher Typ-3-Diabetes des Gehirns • Die Rolle des Schlafs und des glymphatischen Systems • Tipps für Angehörige und Betroffene im Alltag Die Lancet Commission (Update 2024) benennt folgende modifizierbare Risikofaktoren für Demenz: • Bluthochdruck • Adipositas • Körperliche Inaktivität • Diabetes • Rauchen • Übermäßiger Alkoholkonsum • Depression • Soziale Isolation • Hörverlust • Luftverschmutzung • Schädel-Hirn-Trauma • Niedrige Bildung • Hohes LDL-Cholesterin • Unbehandelte Sehschwäche
In this pod Consultant Rheumatologist, Dr Judith Jade, chats with Dr Fergus To, Rheumatologist from British Columbia, about the case of a woman who presented with subacute muscle weakness. They discuss how to approach these types of cases systemically with some handy tips along the way. Listen in and see if you can work out what the diagnosis is!References:1. Blazing M, et al. Effect of statin therapy on muscle symptoms: an individual participant data meta-analysis of large-scale, randomised, double-blind trials. Lancet. 2022;400(10355):832–452. Kim EJ, Wierzbicki AS. Investigating raised creatine kinase. BMJ. 2021;373:1–5.3. Sharf K, Do T, Ghetie D, Choi D, Chahin N. Benefits of Early vs Late Initiation of IVIG in the Treatment of Anti‐HMGCR Immune‐Mediated Necrotizing Myopathy. Arthritis Care Res (Hoboken) 2024;76:1584–92. https://doi.org/10.1002/acr.25406.4. Allenbach et al, 224th ENMC International Workshop, Neuromuscular Disorders, Volume 28, Issue 1, 87 - 99Thanks for listening to Talking Rheumatology! Join the conversation on X using #TalkingRheum or tweet us @RheumatologyUK.BSR is the UK's leading specialist medical society for rheumatology and MSK health professionals. To discover how we can support you in delivering the best care for your patients, visit our website.
Climate Education for YouthClimate education has the potential to drive the public towards climate science literacy, an individual's understanding of their influence on climate and climate's influence on them and society. According to the National Oceanic and Atmospheric Administration, a climate-literate person: understands the essential principles of Earth's climate system,knows how to assess scientifically credible information about climate,communicates about climate and climate change in a meaningful way, andis able to make informed and responsible decisions with regard to actions that may affect climate.Climate change education is more than just science education; it is an interdisciplinary topic that involves understanding the relationship between climate change, history, economics, social studies, and more. A robust and interdisciplinary climate education provides an understanding of the large-scale social transformation necessary to increase climate resiliency and implement effective solutions.Empowering Future Solution Makers Climate education can provide younger generations with the knowledge, skills, attitudes, and values that are necessary to make more environmentally informed decisions. By equipping students with a thorough understanding of climate science and illuminating the scientific process utilized by climate scientists, students become armed to critically assess climate discourse and solutions. Moreover, climate education fosters a sense of agency: youth may grow up to vote for climate positive policies, pursue careers that strive towards climate solutions, have a more eco-conscious lifestyle, or facilitate constructive conversations with family members and friends. Implementing effective climate solutions relies on an informed public, and climate education provides youth with a starting point to act as agents of positive change amidst our planetary emergency. Additionally, climate education can provide youth with the tools necessary to alleviate and cope with climate anxiety. A 2021 Lancet Study asked 10,000 young people between the ages of 16–25 in ten countries what they felt about climate change, and found that more than 50% of young people reported experiencing sadness, anxiety, anger, powerlessness, helplessness, and guilt. Effective climate education will not only help youth understand the causes and impacts of climate change, but it will also provide young people with insight on how they can contribute to solutions and exercise their own agency to make meaningful changes. Further, climate education can provide coping strategies by fostering hope and highlighting the collective efforts being made to address climate change. Barriers to Effective Climate Education According to an article from Science, data from 1500 public middle- and high-school science teachers from all 50 US states found that the median teacher devotes only one to two hours to climate change instruction. Climate confusion among U.S. teachers further contributes to this educational gap within American education, and limited training and scientific consensus among teachers leads to mixed messages. For example, the research published in Science found that of the teachers who teach climate change, “31% report sending explicitly contradictory messages, emphasizing both the scientific consensus that recent global warming is due to human activity and that many scientists believe recent increases in temperature are due to natural causes.” Progress in climate science and scientific consensus have outpaced teachers' training. Additionally, teachers may face political threats and external pressures from parents or administration to avoid climate instruction. Teachers' lack of knowledge on climate science and exclusion of climate instruction is further compounded by variations in learning standards and requirements. Climate education within the US faces challenges due to the absence of consensus on the inclusion of climate change in educational curricula and the absence of national science standards on the subject. In 2013, the Next Generation Science Standards (NGSS) were developed and recommended that human-made climate change be taught in all science classes beginning in fifth grade. However, these standards remain voluntary, and 44 states have used the NGSS or created standards based on them. Since 2007, The Campaign for Environmental Literacy has continued to organize stakeholders and push for passage of the Climate Change Education Act, leading to the subsequent efforts to reintroduce and pass the bill four times since then. Despite these efforts, federal grants to fund climate change education projects have been miniscule and initiatives in Congress to support climate change education have been unsuccessful. New Jersey became a pioneer in climate education in 2020, becoming the first state to mandate the teaching of climate change beginning in kindergarten. Notably, New Jersey has taken an interdisciplinary approach to climate education as students are learning about climate change in ceramics and physical education classes. Making Climate Change Education Accessible and Engaging for YouthOutside of the traditional classroom setting, many environmental organizations, activists, content creators, and informal education institutions like museums or zoos provide opportunities for students to engage in climate education. Collectively, these actors play critical roles as environmental educators who bridge the educational gaps related to climate change and increase climate literacy amongst young people. In an era dominated by digital communication, media serves as a dynamic and influential tool in climate education initiatives. In a survey conducted by the EdWeek Research Center, social media emerged as the third most frequently mentioned source of information on climate change amongst teenagers. Young people consume climate-related media through various social media platforms, like YouTube, Instagram, and TikTok. Environmental educators understand that leveraging various forms of media allows them to create engaging, relatable, and inspiring climate education for today's youth. While leveraging these platforms to educate youth and the wider public on climate change, storytelling remains a central element. Media-driven climate education empowers environmental educators to effectively break down barriers and make climate science more accessible, relatable, and inspiring for youth of all ages. Who is Suzie Hicks?Suzie Hicks is an award-winning filmmaker, author and television host specializing in environmental communication for kids of all ages. Suzie emphasizes the power of children's media and learning communities, connecting youth advocates and educator allies. Their current project includes “Suzie Hicks the Climate Chick,” which started out as a college-produced Studio TV series, then transformed into a preschool teaching persona, a social media account, and now an award-winning children's pilot. “Suzie Hicks the Climate Chick” aims to educate everyone about the local impacts and solutions of climate change through puppetry, comedy, and music. ResourcesSuzie Hicks Website United Nations, Education is key to addressing climate changeNOAA, What is Climate Science Literacy?Hickman et al., Climate anxiety in children and young people and their beliefs about government responses to climate change: a global survey (The Lancet, 2021)Plutzer et al., Climate Confusion Among U.S. Teachers (Science, 2016)Renee Cho, Climate Education in the U.S.: Where It Stands, and Why It Matters (Columbia Climate School, 2023)Next Generation Science Standards (NGSS)Seyma Bayram, New Jersey requires climate change education. A year in, here's how it's going (NPR, 2023).Arianna Prothero, Most Teens Learn About Climate Change From Social Media. Why Schools Should Care (EdWeek, 2023)Cleary Vaughan-Lee, Executive Director of Global Oneness Project, Immersive Storytelling and Climate Change: Fostering the Development of Social-Emotional Learning (UNESCO Mahatma Gandhi Institute of Education for Peace and Sustainable Development)For a transcript of this episode, please visit https://climatebreak.org/educating-kids-about-climate-change-through-musical-storytelling/
Bertie speaks with Mark Parrington about this year's record-breaking wildfires, and the health implications of increasing air pollution. Mark is a senior scientist at the EU's Copernicus Atmosphere Monitoring Service, where he uses satellite imagery to monitor wildfire emissions in real-time. He tells Bertie about the scale of the recent surge in wildfires across Europe, North America, and the Arctic, and the health impacts of particulate matter and long-range pollution transport. They also discuss the climate implications as wildfires – especially in Arctic peatlands - release millions of tonnes of CO2 into the atmosphere. Further reading: Arctic Climate Change Update 2024: Key Trends and Impacts, AMAP , 2024 State of Wildfires 2023-2024, Earth System Science Data, 2024 'Global, regional, and national mortality burden attributable to air pollution from landscape fires: a health impact assessment study', The Lancet, 2024 'EU wildfires worst on record as burning season continues', The Guardian, 2025 'Why are Europe and the Arctic heating up faster than the rest of the world?' Copernicus, 2025 'Current wildfire situation in Europe', The Joint Research Centre: EU Science Hub, 2025 Click here for our website to read all our most recent Land and Climate Review features and pieces.
Gavin, Richard, and Jessamy enter the studio once more for a Lancet Voice chat. A new book on Alzheimer's disease causes controversy across the Lancet team, we discuss the new Countdown on Plastics & Health, and a quick look at the problems facing the upcoming UN High Level Meeting on NCDs.You can read the Lancet Countdown on health and plastics here:https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)01447-3/fulltext?dgcid=buzzsprout_tlv_podcast_August_25_lancetSend us your feedback!Read all of our content at https://www.thelancet.com/?dgcid=buzzsprout_tlv_podcast_generic_lancetCheck out all the podcasts from The Lancet Group:https://www.thelancet.com/multimedia/podcasts?dgcid=buzzsprout_tlv_podcast_generic_lancetContinue this conversation on social!Follow us today at...https://thelancet.bsky.social/https://instagram.com/thelancetgrouphttps://facebook.com/thelancetmedicaljournalhttps://linkedIn.com/company/the-lancethttps://youtube.com/thelancettv
Season Six of The Food Professor Podcast, presented by Caddle, kicks off with hosts Michael LeBlanc and Dr. Sylvain Charlebois diving into a whirlwind of summer news, trade turbulence, and big-picture food industry shifts. This debut episode sets the tone for what promises to be a dynamic and thought-provoking season.Michael and Sylvain begin with personal updates from a busy summer, including travels to Quebec City, Sylvain's new role as Visiting Scholar at McGill University, and Michael's experiences covering retail in New York. They also announce that full video episodes of The Food Professor are now available on YouTube, expanding the show's reach as podcasting and video continue to converge.The discussion quickly pivots to critical economic and policy issues. The hosts unpack Ottawa's decision to end retaliatory countervailing tariffs on U.S. food imports—a move Sylvain argues was long overdue, as tariffs only raised costs for Canadian consumers while doing little to protect domestic industries. With food inflation running hot, Sylvain predicts prices will ease by early fall, pointing to statements from Loblaw CEO Per Bank as validation.From there, the pair explore the elimination of the U.S. “de minimis” exemption, a decision with far-reaching consequences for Canadian small businesses and independent food producers shipping across the border. Michael emphasizes how indie retailers relying on U.S. customers will be hit hardest, while Sylvain warns that Ottawa must address Canada's own $150 threshold to avoid worsening inequities.The conversation expands globally with a deep dive into China's escalating tariffs on Canadian canola, pork, and lobster—measures Sylvain interprets as retaliation for Canada's 100% tariff on Chinese EVs. He makes the case for a more nuanced approach: segment tariffs between luxury and affordable EVs, allowing consumers greater choice while protecting farmers from geopolitical fallout.Other highlights include an analysis of the pickle aisle—yes, really—where the Bick's withdrawal from Canada illustrates the tangled realities of cross-border food supply chains. The hosts also discuss Dr Pepper Keurig's acquisition of JDE Peet's, situating it within a larger trend of consumer packaged goods giants restructuring in response to inflation, climate change, GLP-1 weight-loss drugs, and a rewiring of global trade flows.The episode wraps on a lighter note, celebrating the Canadian arrival of Bobby Flay's Burger concept and teasing next week's guest, Globe and Mail journalist Greg Mercer, author of The Lobster Trap.With sharp analysis, lively banter, and a keen eye on the forces reshaping food and retail, Michael and Sylvain set the stage for a season that will track how consumers, farmers, and retailers navigate inflation, trade disputes, shifting supply chains, and new food trends. The Food Professor #podcast is presented by Caddle. About UsDr. Sylvain Charlebois is a Professor in food distribution and policy in the Faculties of Management and Agriculture at Dalhousie University in Halifax. He is also the Senior Director of the Agri-food Analytics Lab, also located at Dalhousie University. Before joining Dalhousie, he was affiliated with the University of Guelph's Arrell Food Institute, which he co-founded. Known as “The Food Professor”, his current research interest lies in the broad area of food distribution, security and safety. Google Scholar ranks him as one of the world's most cited scholars in food supply chain management, food value chains and traceability.He has authored five books on global food systems, his most recent one published in 2017 by Wiley-Blackwell entitled “Food Safety, Risk Intelligence and Benchmarking”. He has also published over 500 peer-reviewed journal articles in several academic publications. Furthermore, his research has been featured in several newspapers and media groups, including The Lancet, The Economist, the New York Times, the Boston Globe, the Wall Street Journal, Washington Post, BBC, NBC, ABC, Fox News, Foreign Affairs, the Globe & Mail, the National Post and the Toronto Star.Dr. Charlebois sits on a few company boards, and supports many organizations as a special advisor, including some publicly traded companies. Charlebois is also a member of the Scientific Council of the Business Scientific Institute, based in Luxemburg. Dr. Charlebois is a member of the Global Food Traceability Centre's Advisory Board based in Washington DC, and a member of the National Scientific Committee of the Canadian Food Inspection Agency (CFIA) in Ottawa. Michael LeBlanc is the president and founder of M.E. LeBlanc & Company Inc, a senior retail advisor, keynote speaker and now, media entrepreneur. He has been on the front lines of retail industry change for his entire career. Michael has delivered keynotes, hosted fire-side discussions and participated worldwide in thought leadership panels, most recently on the main stage in Toronto at Retail Council of Canada's Retail Marketing conference with leaders from Walmart & Google. He brings 25+ years of brand/retail/marketing & eCommerce leadership experience with Levi's, Black & Decker, Hudson's Bay, CanWest Media, Pandora Jewellery, The Shopping Channel and Retail Council of Canada to his advisory, speaking and media practice.Michael produces and hosts a network of leading retail trade podcasts, including the award-winning No.1 independent retail industry podcast in America, Remarkable Retail with his partner, Dallas-based best-selling author Steve Dennis; Canada's top retail industry podcast The Voice of Retail and Canada's top food industry and one of the top Canadian-produced management independent podcasts in the country, The Food Professor with Dr. Sylvain Charlebois from Dalhousie University in Halifax.Rethink Retail has recognized Michael as one of the top global retail experts for the fourth year in a row, Thinkers 360 has named him on of the Top 50 global thought leaders in retail, RTIH has named him a top 100 global though leader in retail technology and Coresight Research has named Michael a Retail AI Influencer. If you are a BBQ fan, you can tune into Michael's cooking show, Last Request BBQ, on YouTube, Instagram, X and yes, TikTok.Michael is available for keynote presentations helping retailers, brands and retail industry insiders explaining the current state and future of the retail industry in North America and around the world.
Send us a Text Message (please include your email so we can respond!)Episode 72! We continue talking about the articles from the CCR25 conference with UK-ROX or "Conservative Oxygen Therapy in Mechanically Ventilated Critically Ill Adult Patients" published in JAMA 2025 by Martin et al and TARGET-Protein or "Sodium bicarbonate therapy for patients with severe metabolic acidaemia in the intensive care unit" by Jaber et al in Lancet 2018.UK-ROX: https://pubmed.ncbi.nlm.nih.gov/40501321/UK-ROX (JAMA): https://jamanetwork.com/journals/jama/article-abstract/2835384TARGET-Protein: https://pubmed.ncbi.nlm.nih.gov/40495743/TARGET-Protein (JAMA): https://jamanetwork.com/journals/jama/article-abstract/2835302If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!
IQBAR is offering our special podcast listeners 20% OFF all IQBAR products, plus get FREE shipping. To get your 20% off, text VANESSA to 64000. That's VANESSA to sixty-four thousand. Message and data rates may apply. See terms for details. In today's episode, Vanessa sits down with Dr. Samuel Dicken, Research Fellow at University College London's Centre for Obesity Research and lead author of the UPDATE Trial — the longest and most rigorous clinical study to date comparing ultra-processed (UPF) vs. minimally processed (MPF) diets. This landmark trial revealed a game-changing finding:
Ralph welcomes Ben Cohen (anti-war activist and ice cream entrepreneur) to discuss his new campaign, "Up in Arms," which advocates for a common-sense Pentagon budget. Then, Ralph speaks to Guardian columnist Arwa Mahdawi about her recent piece: "When will we finally admit: the Gaza death toll is higher than we've been told."Ben Cohen is an entrepreneur, philanthropist, and longtime anti-war activist. He is a co-founder of the ice cream company Ben & Jerry's and a prominent supporter of progressive causes. He is co-founder of Up In Arms, a public education and advocacy campaign pushing for a common-sense approach to military budgeting. In May of this year, Ben was arrested by Capitol Police after he interrupted Robert F. Kennedy Jr.'s testimony by screaming,”Congress kills poor kids in Gaza by buying bombs and pays for it by kicking kids off Medicaid.”We're up in arms because the government has taken the kindness, the heart, the soul of the American people and essentially replaced it with so many bombs that there's no rational use for them. They've turned us all into mass murderers.Ben CohenYou know, politicians starting from Reagan are fond of saying “a nuclear war cannot be won and must never be fought.” And then they turn around and spend $100 billion a year on a nuclear arsenal that's capable of blowing up the entire world several times over. So they say one thing and they do another. I mean, a nuclear arsenal capable of blowing up the entire world several times over? That's not deterrence. That's delusion.Ben CohenI just go back to the moral issue of our time, which is Gaza—two-thirds of the American people don't support continuing to arm Israel. And we need to make our politicians pay the price for continuing to arm Israel… We have a midterm election coming up. If your guy voted to continue to essentially facilitate the genocide, vote them out.Ben CohenWhen you have more money than is needed, you tend to invite corruption, cost overruns, machinery that doesn't work, and I would advise that you look into why the GAO and the Pentagon auditors are being asked to do fewer audits of the military budget. Because there's almost a direct correlation between throwing money at a government program (especially at that scale) and corruption. And corruption is understandable to everybody. It's the number one political issue all over the world, when the pollsters poll.Ralph NaderArwa Mahdawi is a columnist for the Guardian and author of Strong Female Lead: Lessons from Women in Power. Here is her recent piece on the genocide in Gaza: “When will we finally admit: the Gaza death toll is higher than we've been told” (The Guardian, August 8, 2025)To be fair, the New York Times, Washington Post, and Wall Street Journal have published some pretty devastating reports from their reporters in that area. They've put out some devastating features on what's going on [in Gaza], but it doesn't translate into editorial denunciation by these papers. And it doesn't translate into taking the next step and doing what they would do in other conflicts around the world where there isn't so much prejudice and domestic pressureRalph NaderI'm an opinion writer, but as journalists, you're always supposed to report facts. And the fact is: we have absolutely no idea how many people are dead in the Gaza Strip. But there are plenty of studies (which I reference in the article—one Lancet peer-reviewed study, one letter to the Lancet by a highly-respected scientist, one empirical study by Michael Spagat) which show that the death count is a lot higher. So I truly believe that unless you're saying “the official figure from the Ministry of Health is around 60,000 but studies show it is probably much higher,” then that's just journalistic malpractice.Arwa MahdawiI think there's just this instinct to believe that Palestinians are lying and Israelis are telling the truth. And it also goes back to…this isn't just Israel's war, this is America's war as well. And this desire to see America as the good guys—we're the good guys, the Palestinians are the bad guys. And to have this black-and-white narrative where, obviously, we're the good guys, you know, and so if the Palestinian narrative casts doubt on that, then it must be wrong.Arwa MahdawiI always suggest that people write to the media outlets and say that they want to see more Palestinian narratives, they want the media outlets to voice their concern that foreign reporters are not being let in, that more aid workers are not being let in, that pictures are not coming out.Arwa MahdawiThere are very few pictures coming out of the scale of this destruction in Gaza, but when you see the ones that do come out, it is very, very obvious that there are more than 60,000 people dead.But there seems to be this lack of curiosity with some of my peers. Why aren't they asking, “Why aren't we seeing more pictures?” There should be nonstop outrage that their press freedom is being stifled like this and so many Palestinian journalists are being slaughtered.Arwa MahdawiNews 8/22/25* Last Thursday, during an event in her Masscusetts congressional district, Congresswoman Katherine Clark – who holds the position of House Minority Whip, making her the number two Democrat in the House – called Israel's campaign in Gaza a “genocide,” per Axios. According to Zeteo, this makes Clark the 14th member of Congress to use the “g word.” Lest she be accused of bravery however, Clark quickly walked back her comments. In a statement to the Jewish News Syndicate, Clark said “last week, while attending an event in my district, I repeated the word ‘genocide' in response to a question…I want to be clear that I am not accusing Israel of genocide.” This incident illustrates the cross-cutting pressures facing Democratic Party leaders. This divide will be on the agenda again at the DNC meeting on August 26th, where among other issues, party leaders will vote on competing resolutions to lay out the Democrats' position on Gaza. Allison Minnerly, the progressive DNC delegate sponsoring the resolution to end arms shipments to Israel, is quoted saying “Our voters…are saying that they do not want U.S. dollars to enable further death and starvation anywhere across the world, particularly in Gaza…I don't think it should be a hard decision for us to say that clearly,” per the Intercept.* Even as Democrats wrestle with their position on Gaza, the politics are clearly shifting. The Reject AIPAC coalition has released a new statement saying that among Democrats, AIPAC is now a “toxic pariah.” As evidence of this, Reject AIPAC cites the fact that only 14 House Democrats attended the AIPAC-sponsored Israel trip this year. According to Mondoweiss, “In 2023, the lobbying group brought 24 House Dems to Israel over recess. In 2019, over 40 attended.” Reject AIPAC also cites the fact that Reps. Valerie Foushee and Maxine Dexter, both recipients of millions of AIPAC dollars, voted to block arms to Israel and Foushee is even now rejecting AIPAC money. As these small victories mount, the horizon of possibility for movement within the party grows ever wider.* Last week, Tom Artiom Alexandrovich – a senior department head in Israel's National Cyber Directorate – was arrested in a “multi-agency operation targeting child sex predators,” in Clark County, Nevada according to the Las Vegas Metropolitan Police Department. According to Reuters, “Alexandrovich faces a felony charge of luring or attempting to lure a child or mentally ill person to commit a sex act ‘with use of computer technology.'” Yet, inexplicably, Alexandrovich was released by U.S. authorities and is back in Israel. This set off a firestorm in the U.S., with many accusing the Trump administration of facilitating Alexandrovich's release. The State Department was forced to issue a statement denying these claims, stating that Alexandrovich "did not claim diplomatic immunity and was released by a state judge…Any claims that the U.S. government intervened are false." The AP adds that the “Israeli Embassy in Washington and the Israeli Prime Minister's Office did not immediately return messages.” Disturbingly, the mainstream media seems to be purposely ignoring this case. While it has been covered by the Guardian, the Times of Israel, and Haaretz, there has been zero coverage in the New York Times or Washington Post, or ABC, NBC, or CBS. This media blackout adds fuel to the speculation that this case is being tamped down by the administration for political reasons.* Another troubling story regarding minors on the internet comes to us from Mark Zuckerberg's Meta AI. According to Reuters, internal documents from Meta Platforms detail “policies on chatbot behavior…[permitting] the company's artificial intelligence creations to ‘engage a child in conversations that are romantic or sensual,' generate false medical information and help users argue that Black people are ‘dumber than white people.'” Former Federal Trade Commission Chair Lina Khan called these reports “disturbing” and cited a legal complaint filed by the FTC to the Justice Department against Snap in January, under her leadership, “charging that [Snap's] AI chatbot was creating risks and harms for young users.” Khan noted that the “DOJ hasn't filed the case or taken any steps to protect these kids,” and demanded that “Any lawmaker concerned about big tech's abuse of kids should ask what is going on.” The administration's lack of action on these issues indicates that despite their rhetorical inveighing against the tech industry, they are treating SIlicon Valley with the same kid gloves they use for the rest of corporate America, even when it affects minors.* In more positive news from abroad, the Washington Post reports that between 2022 and 2024, Mexico lifted a stunning 8.3 million residents out of poverty. This 18% drop in poverty includes a 23% decrease in extreme poverty and a 16% drop in moderate poverty. According to experts, this remarkable achievement is the result of the policies of former President Andres Manuel Lopez Obrador, or AMLO, and his successor Claudia Sheinbaum, such as tripling the minimum wage and instituting a raft of social programs to aid “senior citizens, unemployed youth, students, farmers and people with disabilities.” President Sheinbaum is now plowing ahead with a new project – producing a “small, 100% electric, accessible [EV],” called the “Olinia,” to be fully manufactured and assembled in Mexico, per Mexico News Daily.* Turning to domestic politics, Congresswoman Elise Stefanik finally showed up in her district on Monday after an extended period of avoiding public appearances. At a ceremony honoring a late Clinton County clerk in Plattsburgh, Stefanik was drowned out by cries of “‘You sold us out!', ‘Shame!', and ‘Unseal the Epstein files!', along with a “steady stream of boos,” according to the Daily Beast. Stefanik “left the podium after speaking for less than a minute,” and when she returned, she was booed again. Stefanik's chronic absence and chilly reception is a bad sign for her gubernatorial aspirations. In the months since she has held a town hall, her constituents held a mock town hall where they addressed an empty chair, per WRGB, and New York Democrats AOC and Paul Tonko held town halls in her district, per the Albany Times-Union.* In more political news from New York, disgraced former Governor Andrew Cuomo is explicitly seeking to woo New York Republicans in his independent bid for Mayor of New York City. POLITICO reports that at a fundraiser at media mogul Jimmy Finkelstein's Southampton estate, Cuomo told the crowd that he agrees with President Trump that the “goal is to stop Mamdani.” To this end, he is trying to convince Republicans that they would be “wasting [their] vote on [Curtis] Sliwa,” the Republican nominee for Mayor, “because he'll never be a serious candidate.” Cuomo also implied that he is open to an alliance with Trump, telling the crowd “Let's put it this way: I knew the president very well.” Dora Pekec, a spokesperson for the Zohran campaign, is quoted saying “Since he's too afraid to say it to New Yorkers' faces, we'll make it clear: Andrew Cuomo IS Donald Trump's choice for mayor.”* In Texas, state Democrats have returned to the state, ending their attempt to defeat Governor Abbott's mid-decade redistricting scheme by denying the legislature a quorum. In a statement Gene Wu, chairman of the Texas House Democratic Caucus, said "We killed the corrupt special session, withstood unprecedented surveillance and intimidation, and rallied Democrats nationwide to join this existential fight for fair representation — reshaping the entire 2026 landscape," per the BBC. The legislature is now expected to approve the redrawn congressional maps; the state Democrats plan to continue fighting them in the courts. California has vowed to redraw their own maps to compensate for the expected loss of five Democrat-held seats in Texas. New York, New Jersey, New Hampshire and Maryland are also considering their own redistricting plans. Vice President JD Vance was deployed to Indiana to pressure Republicans in that state to redraw their maps to favor Republicans as well, per the IndyStar. It is a sad state of affairs that American politics has been reduced to such naked power grabbing plots, but here we are.* In local news, the federal occupation of Washington, D.C. continues to deepen. CBS reports the governors of at least six Republican-led states are sending contingents from their National Guards to the capital. These include Mississippi and Louisiana, West Virginia, South Carolina, Ohio and Tennessee. Just what these troops will do in Washington remains unclear. Tennessee Governor Bill Lee, who is sending 160 troops, cited “monument security” and “traffic control” among their official responsibilities. The federal agents on the ground, with little to do – the DOJ itself reports as violent crime is at a 30-year low in the District – seem to be mostly just harassing residents. The Daily Beast reports ICE tore down a banner and replaced it with a dildo. A local, Amanda Moore, posted a photo of 15 federal agents calling an ambulance for a drunk girl in Dupont Circle. And, while the Lever reports D.C. corporate lobbyists pushed for the occupation, it is wreaking havoc on local businesses; Rolling Stone reports reservations at D.C. restaurants are down between 25 and 31%, to take just one example. We can only hope that this pointless, destructive farce of quasi-fascistic political theater ends sooner rather than later.* Finally, investigative reporter and Iraq war veteran Seth Harp is out with a new book – The Fort Bragg Cartel: Drug Trafficking and Murder in the Special Forces – which details the double murder of Master Sergeant Billy Lavigne and Chief Warrant Officer Timothy Dumas, along with the “many more unexplained deaths…other murders connected to drug trafficking in elite units, and dozens of fatal overdoses,” at Fort Bragg in North Carolina. Among other remarkable discoveries, Harp “describes a U.S. special forces k9 [unit] that was given titanium dentures and encouraged to feast on human brains in the field,” in the words of publisher and producer Chris Wade. Remember these titanium dentures whenever you hear that there is no money to pay for critical social programs. The money is there. The political will is not.This has been Francesco DeSantis, with In Case You Haven't Heard. Get full access to Ralph Nader Radio Hour at www.ralphnaderradiohour.com/subscribe
Drs. Whitney Hartlage (@whithartlage11) and Sam Windham join Dr. Ryan Moenster to discuss updates in the diagnosis and management of community-acquire pneumonia. Hear from our guests on the role of rapid diagnostic tests such as multiplex PCR and urinary antigen tests in the inpatient and outpatient setting, considerations for initiating steroids and withholding macrolides, and when to use short antibiotic durations. Listen to Breakpoints on iTunes, Overcast, Spotify, Listen Notes, Player FM, Pocket Casts, TuneIn, Blubrry, RadioPublic, or by using our RSS feed: https://sidp.pinecast.co/. Visit our website! https://breakpoints-sidp.org/ References: Metlay JP, Waterer GW, Long AC, Anzueto A, Brozek J, Crothers K, Cooley LA, Dean NC, Fine MJ, Flanders SA, Griffin MR, Metersky ML, Musher DM, Restrepo MI, Whitney CG. Diagnosis and Treatment of Adults with Community-acquired Pneumonia. An Official Clinical Practice Guideline of the American Thoracic Society and Infectious Diseases Society of America. Am J Respir Crit Care Med. 2019 Oct 1;200(7):e45-e67. doi: 10.1164/rccm.201908-1581ST. PMID: 31573350; PMCID: PMC6812437. Chaudhuri D, Nei AM, Rochwerg B, Balk RA, Asehnoune K, Cadena R, Carcillo JA, Correa R, Drover K, Esper AM, Gershengorn HB, Hammond NE, Jayaprakash N, Menon K, Nazer L, Pitre T, Qasim ZA, Russell JA, Santos AP, Sarwal A, Spencer-Segal J, Tilouche N, Annane D, Pastores SM. 2024 Focused Update: Guidelines on Use of Corticosteroids in Sepsis, Acute Respiratory Distress Syndrome, and Community-Acquired Pneumonia. Crit Care Med. 2024 May 1;52(5):e219-e233. doi: 10.1097/CCM.0000000000006172. Epub 2024 Jan 19. PMID: 38240492. Odeyemi Y, Tekin A, Schanz C, Schreier D, Cole K, Gajic O, Barreto E. Comparative effectiveness of azithromycin versus doxycycline in hospitalized patients with community acquired pneumonia treated with beta-lactams: A multicenter matched cohort study. Clin Infect Dis. 2025 May 16:ciaf252. doi: 10.1093/cid/ciaf252. Epub ahead of print. PMID: 40378193. Butler AM, Nickel KB, Olsen MA, Sahrmann JM, Colvin R, Neuner E, O'Neil CA, Fraser VJ, Durkin MJ. Comparative safety of different antibiotic regimens for the treatment of outpatient community-acquired pneumonia among otherwise healthy adults. Clin Infect Dis. 2024 Oct 23:ciae519. doi: 10.1093/cid/ciae519. Epub ahead of print. PMID: 39442057; PMCID: PMC12355227. Furukawa Y, Luo Y, Funada S, Onishi A, Ostinelli E, Hamza T, Furukawa TA, Kataoka Y. Optimal duration of antibiotic treatment for community-acquired pneumonia in adults: a systematic review and duration-effect meta-analysis. BMJ Open. 2023 Mar 22;13(3):e061023. doi: 10.1136/bmjopen-2022-061023. 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Evaluation of point-of-care multiplex polymerase chain reaction in guiding antibiotic treatment of patients acutely admitted with suspected community-acquired pneumonia in Denmark: a multicentre randomised controlled trial. PLoS Med. 2023;20:e1004314. doi: 10.1371/ journal.pmed.1004314. Vaughn VM, Dickson RP, Horowitz JK, Flanders SA. Community-acquired pneumonia: a review. JAMA. 2024;332(15):1282-1295. Davis MR, McCreary EK, Trzebucki AM. Things we do for no reason – ordering Streptococcus pneumoniae urinary antigen in patients with community-acquired pneumonia. Open Forum Infect Dis. 2024;11(3):ofae089. Centers for Disease Control and Prevention. Laboratory Testing for Legionella. Updated June 9, 2025. Accessed July 13, 2025. https://www.cdc.gov/legionella/php/laboratories/index.html. Jain S, Self WH, Wunderink RG. Community-acquired pneumonia requiring hospitalization among U.S. adults. N Engl J Med. 2015;373(5):415-427. Kamat IS, Ramachandram V, Eswaran H, Guffey D, Musher DM. Procalcitonin to distinguish viral from bacterial pneumonia: a systematic review and meta-analysis. Clin Infect Dis. 2020;70(3):538-542. Christ-Crain M, Jaccard-Stolz D, Bingisser R, Gencay MM, Huber PR, Tamm M, et al. Effect of procalcitonin-guided treatment on antibiotic use and outcome in lower respiratory tract infections: cluster-randomised, single blinded intervention trial. Lancet. 2004;363:600–7. doi: 10.1016/S0140- 6736(04)15591-8. Schuetz P, Christ-Crain M, Thomann R, Falconnier C, Wolbers M, Widmer I, et al. Effect of procalcitonin-based guidelines vs standard guidelines on antibiotic use in lower respiratory tract infections: the ProHOSP randomized controlled trial. JAMA. 2009;302:1059–66. Schuetz P, Muller B, Christ-Crain M, Stolz D, Tamm M, Bouadma L, et al. Procalci- € tonin to initiate or discontinue antibiotics in acute respiratory tract infections. Cochrane Datab System Rev. 2017;10(10):CD007498. doi: 10.1002/14651858. cd007498.pub2. Huang DT, Yealy DM, Filbin MR, Brown AM, Chang C-CH, Doi Y, et al. Procalcitonin-guided use of antibiotics for lower Respiratory tract infection. New Engl J Med. 2018;379:236–49. doi: 10.1056/NEJMoa1802670. Dequin PF, Meziani F, Quenot JP, et al. Hydrocortisone in severe community-acquired pneumonia. N Engl J Med. 2023;389(19):1623-1634. doi:10.1056/NEJMoa2215145. Gupta AB, Flanders SA, Petty LA, et al. Inappropriate diagnosis of pneumonia among hospitalized adults. JAMA Intern Med. 2024;184(5):548-556. Jones BE, Chapman AB, Ying J, et al. Diagnostic Discordance, Uncertainty, and Treatment Ambiguity in Community-Acquired Pneumonia: A National Cohort Study of 115 U.S. Veterans Affairs Hospitals. Ann Intern Med. 2024;177(9):1179-1189. doi:10.7326/M23-2505. Hartlage W, Imlay H, Spivak ES. The role of empiric atypical antibiotic coverage in non-severe community-acquired pneumonia. Antimicrob Steward Healthc Epidemiol. 2024;4(1):e214. doi:10.1017/ash.2024.453. Dinh A, Barbier F, Bedos JP, et al. Update of guidelines for management of community acquired pneumonia in adults by the French Infectious Disease Society (SPILF) and the French-Speaking Society of Respiratory Diseases (SPLF). Endorsed by the French Infectious Disease Society (SPILF) and the French-Speaking Society of Respiratory Diseases (SPLF); endorsed by the French Intensive Care Society (SRLF), the French Microbiology Society (SFM), the French Radiology Society (SFR), and the French Emergency Society (SFMU). Respir Med and Res. 2025. El Moussaoui R, de Borgie CAJM, van den Broek P, et al. Effectiveness of discontinuing antibiotic treatment after three days versus eight days in mild to moderate-severe community acquired pneumonia: randomised, double blind study. BMJ. 2006;332(7554):1355. doi:10.1136/bmj.332.7554.1355. Dinh A, Ropers J, Duran C, et al. Discontinuing β-lactam treatment after 3 days for patients with community-acquired pneumonia: a randomized, non-inferiority trial. 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******Support the channel******Patreon: https://www.patreon.com/thedissenterPayPal: paypal.me/thedissenterPayPal Subscription 1 Dollar: https://tinyurl.com/yb3acuuyPayPal Subscription 3 Dollars: https://tinyurl.com/ybn6bg9lPayPal Subscription 5 Dollars: https://tinyurl.com/ycmr9gpzPayPal Subscription 10 Dollars: https://tinyurl.com/y9r3fc9mPayPal Subscription 20 Dollars: https://tinyurl.com/y95uvkao ******Follow me on******Website: https://www.thedissenter.net/The Dissenter Goodreads list: https://shorturl.at/7BMoBFacebook: https://www.facebook.com/thedissenteryt/Twitter: https://x.com/TheDissenterYT This show is sponsored by Enlites, Learning & Development done differently. Check the website here: http://enlites.com/ Dr. Kristen Ghodsee is an award-winning author and professor and chair of Russian and East European Studies at the University of Pennsylvania. She also serves as a member on the graduate groups of Anthropology and Comparative Literature. Dr. Ghodsee's articles and essays have been translated into over twenty-five languages and have appeared in publications such as Dissent, Foreign Affairs, Jacobin, The Baffler, The New Republic, Quartz, NBC Think, The Lancet, Project Syndicate, Le Monde Diplomatique, Die Tageszeitung, The Washington Post, and the New York Times. She is the author of 12 books, including Everyday Utopia: What 2,000 Years of Wild Experiments Can Teach Us About the Good Life. In this episode, we focus on Everyday Utopia. We first discuss what is a “utopia”, social experiments in the 18th and 19th centuries, and Pythagoras. We talk about family and gender roles, the cohousing movement in Denmark, the Israeli kibbutzim, matriarchal Colombian ecovillages, planned microdistricts in China, and monastic life. We also discuss the importance of education, communism, what we can learn by studying these societies, and the difficulties in implementing utopia.--A HUGE THANK YOU TO MY PATRONS/SUPPORTERS: PER HELGE LARSEN, JERRY MULLER, BERNARDO SEIXAS, ADAM KESSEL, MATTHEW WHITINGBIRD, ARNAUD WOLFF, TIM HOLLOSY, HENRIK AHLENIUS, ROBERT WINDHAGER, RUI INACIO, ZOOP, MARCO NEVES, COLIN HOLBROOK, PHIL KAVANAGH, SAMUEL ANDREEFF, FRANCIS FORDE, TIAGO NUNES, FERGAL CUSSEN, HAL HERZOG, NUNO MACHADO, JONATHAN LEIBRANT, JOÃO LINHARES, STANTON T, SAMUEL CORREA, ERIK HAINES, MARK SMITH, JOÃO EIRA, TOM HUMMEL, SARDUS FRANCE, DAVID SLOAN WILSON, YACILA DEZA-ARAUJO, ROMAIN ROCH, DIEGO LONDOÑO CORREA, YANICK PUNTER, CHARLOTTE BLEASE, NICOLE BARBARO, ADAM HUNT, PAWEL OSTASZEWSKI, NELLEKE BAK, GUY MADISON, GARY G HELLMANN, SAIMA AFZAL, ADRIAN JAEGGI, PAULO TOLENTINO, JOÃO BARBOSA, JULIAN PRICE, HEDIN BRØNNER, DOUGLAS FRY, FRANCA BORTOLOTTI, GABRIEL PONS CORTÈS, URSULA LITZCKE, SCOTT, ZACHARY FISH, TIM DUFFY, SUNNY SMITH, JON WISMAN, WILLIAM BUCKNER, LUKE GLOWACKI, GEORGIOS THEOPHANOUS, CHRIS WILLIAMSON, PETER WOLOSZYN, DAVID WILLIAMS, DIOGO COSTA, ALEX CHAU, CORALIE CHEVALLIER, BANGALORE ATHEISTS, LARRY D. LEE JR., OLD HERRINGBONE, MICHAEL BAILEY, DAN SPERBER, ROBERT GRESSIS, JEFF MCMAHAN, JAKE ZUEHL, BARNABAS RADICS, MARK CAMPBELL, TOMAS DAUBNER, LUKE NISSEN, KIMBERLY JOHNSON, JESSICA NOWICKI, LINDA BRANDIN, VALENTIN STEINMANN, ALEXANDER HUBBARD, BR, JONAS HERTNER, URSULA GOODENOUGH, DAVID PINSOF, SEAN NELSON, MIKE LAVIGNE, JOS KNECHT, LUCY, MANVIR SINGH, PETRA WEIMANN, CAROLA FEEST, MAURO JÚNIOR, 航 豊川, TONY BARRETT, NIKOLAI VISHNEVSKY, STEVEN GANGESTAD, TED FARRIS, HUGO B., JAMES, JORDAN MANSFIELD, CHARLOTTE ALLEN, PETER STOYKO, DAVID TONNER, LEE BECK, PATRICK DALTON-HOLMES, NICK KRASNEY, AND RACHEL ZAK!A SPECIAL THANKS TO MY PRODUCERS, YZAR WEHBE, JIM FRANK, ŁUKASZ STAFINIAK, TOM VANEGDOM, BERNARD HUGUENEY, CURTIS DIXON, BENEDIKT MUELLER, THOMAS TRUMBLE, KATHRINE AND PATRICK TOBIN, JONCARLO MONTENEGRO, NICK GOLDEN, CHRISTINE GLASS, IGOR NIKIFOROVSKI, PER KRAULIS, AND JOSHUA WOOD!AND TO MY EXECUTIVE PRODUCERS, MATTHEW LAVENDER, SERGIU CODREANU, ROSEY, AND GREGORY HASTINGS!
In this special summer bonus episode of The Food Professor Podcast, Michael LeBlanc sits down with Brian Choi, CEO of The Food Institute, for a candid conversation recorded live at the SIAL Canada show. Born in Calgary and now based in New York, Brian brings a unique global perspective on food, trade, and the evolution of consumer behavior.Brian shares the remarkable story of how he acquired the Food Institute in January 2020—mere weeks before the pandemic upended the world. At that time, the Food Institute was a dated print publication struggling to remain relevant. Within two weeks of acquiring the business, Brian devised a three-point turnaround plan and secured early investment, transforming the brand into a digital-first media, data, and advisory company serving clients across food manufacturing, retail, and foodservice. Today, the Food Institute offers proprietary real-time analytics—drawing from menu data, retail insights, and social listening—akin to a Bloomberg terminal for the food industry.From there, the conversation shifts to the pressing challenges shaping the global food landscape. Brian breaks down the impact of U.S. tariffs on food and beverage markets, noting how they have eroded trust in trade relationships and forced companies to reassess strategies. He explains that unlike the pandemic, where leaders expected a “return to normal,” today's tariff-driven environment represents a systemic shift. Companies must now prepare for lasting volatility, requiring a new generation of leaders skilled in scenario planning, geopolitical awareness, and rapid adaptation.Brian and Michael explore how these trade disruptions may push Canada to diversify away from its overwhelming reliance on U.S. markets, drawing comparisons to Australia's successful diversification strategy. They also discuss the challenges of expanding into complex regions like India and Europe, and the critical need for stronger public-private partnerships to strengthen global trade relationships.Looking to the future, Brian reflects on where he would invest $20 million in the Canadian food sector. His answer? Areas that blend health, wellness, and innovation, particularly cleaner ingredients, nutraceuticals, and underutilized natural resources such as berries rich in antioxidants. While he expresses caution about the long-term implications of GLP-1 drugs like Ozempic, he acknowledges their disruptive influence on consumer eating habits and the opportunities this shift may create for food companies. The Food Professor #podcast is presented by Caddle. About UsDr. Sylvain Charlebois is a Professor in food distribution and policy in the Faculties of Management and Agriculture at Dalhousie University in Halifax. He is also the Senior Director of the Agri-food Analytics Lab, also located at Dalhousie University. Before joining Dalhousie, he was affiliated with the University of Guelph's Arrell Food Institute, which he co-founded. Known as “The Food Professor”, his current research interest lies in the broad area of food distribution, security and safety. Google Scholar ranks him as one of the world's most cited scholars in food supply chain management, food value chains and traceability.He has authored five books on global food systems, his most recent one published in 2017 by Wiley-Blackwell entitled “Food Safety, Risk Intelligence and Benchmarking”. He has also published over 500 peer-reviewed journal articles in several academic publications. Furthermore, his research has been featured in several newspapers and media groups, including The Lancet, The Economist, the New York Times, the Boston Globe, the Wall Street Journal, Washington Post, BBC, NBC, ABC, Fox News, Foreign Affairs, the Globe & Mail, the National Post and the Toronto Star.Dr. Charlebois sits on a few company boards, and supports many organizations as a special advisor, including some publicly traded companies. Charlebois is also a member of the Scientific Council of the Business Scientific Institute, based in Luxemburg. Dr. Charlebois is a member of the Global Food Traceability Centre's Advisory Board based in Washington DC, and a member of the National Scientific Committee of the Canadian Food Inspection Agency (CFIA) in Ottawa. Michael LeBlanc is the president and founder of M.E. LeBlanc & Company Inc, a senior retail advisor, keynote speaker and now, media entrepreneur. He has been on the front lines of retail industry change for his entire career. Michael has delivered keynotes, hosted fire-side discussions and participated worldwide in thought leadership panels, most recently on the main stage in Toronto at Retail Council of Canada's Retail Marketing conference with leaders from Walmart & Google. He brings 25+ years of brand/retail/marketing & eCommerce leadership experience with Levi's, Black & Decker, Hudson's Bay, CanWest Media, Pandora Jewellery, The Shopping Channel and Retail Council of Canada to his advisory, speaking and media practice.Michael produces and hosts a network of leading retail trade podcasts, including the award-winning No.1 independent retail industry podcast in America, Remarkable Retail with his partner, Dallas-based best-selling author Steve Dennis; Canada's top retail industry podcast The Voice of Retail and Canada's top food industry and one of the top Canadian-produced management independent podcasts in the country, The Food Professor with Dr. Sylvain Charlebois from Dalhousie University in Halifax.Rethink Retail has recognized Michael as one of the top global retail experts for the fourth year in a row, Thinkers 360 has named him on of the Top 50 global thought leaders in retail, RTIH has named him a top 100 global though leader in retail technology and Coresight Research has named Michael a Retail AI Influencer. If you are a BBQ fan, you can tune into Michael's cooking show, Last Request BBQ, on YouTube, Instagram, X and yes, TikTok.Michael is available for keynote presentations helping retailers, brands and retail industry insiders explaining the current state and future of the retail industry in North America and around the world.
Dr. Dan Ackerman talks with Dr. Urs Fischer about the optimal timing of anticoagulation after ischemic stroke in patients with atrial fibrillation. Read the related article in The Lancet. Disclosures can be found at Neurology.org.
The food landscape has undergone a dramatic shift over the years, and the numbers tell a sobering story. A study in The Lancet found that childhood and adolescent obesity rates worldwide have risen nearly fourfold from 1990 to 2022, while adult obesity rates have more than doubled. At the same time, dramatic celebrity weight loss has been linked to Ozempic, an injectable drug containing semaglutide, originally developed to treat type 2 diabetes but now widely used off-label as a weight-loss aid. In this episode of In Focus, we ask: Why is it becoming harder to lose weight? What role do our gut and brain play in shaping our relationship with food? And should drugs like Ozempic step in where lifestyle changes and willpower fall short? Guest: Dr Jack Mosley, the author of Food Noise: How weight loss medications & smart nutrition can silence your cravings Host: Preeti Zechariah Edited by Jude Francis Weston and Sharmada Venkatasubramanian Learn more about your ad choices. Visit megaphone.fm/adchoices
In this flavour-packed episode of The Food Professor Podcast, recorded live at the SIAL Canada Food Innovation Show, Michael LeBlanc and Sylvain Charlebois welcome Dieter Heidegger of Moosbrugger, for an in-depth conversation about the art, tradition, and innovation behind Austria's award-winning cheeses.Dieter shares the fascinating story of Moosbrugger's humble beginnings, tracing its roots back to the owner's father-in-law, a master cheesemaker who started selling cheese from the back of a car. Through passion, creativity, and an unwavering commitment to quality, the company has grown into an internationally recognized brand—most recently winning a gold medal in a prestigious blind tasting in France for its distinctive pine-covered semi-hard cheese.Listeners will learn how Moosbrugger's cheeses stand out in a crowded market through a combination of small-scale, sustainable farming, traditional production methods, and a willingness to innovate with unique flavours that surprise and delight consumers. Dieter explains why sourcing from small farms, minimizing transportation, and working with master cheesemakers ensures both exceptional taste and environmental responsibility.The conversation also dives into the global trade landscape, with Dieter offering first-hand insights into how COVID-19 and shifting geopolitical dynamics have reshaped production strategies, sourcing decisions, and international market opportunities. From reducing dependency on far-flung suppliers to embracing slower, more deliberate distribution models, Moosbrugger is adapting to a more resilient, future-focused approach to food production.Innovation plays a central role in Moosbrugger's long-term success. Dieter reveals how the company's development process blends open-minded trend awareness with rigorous product testing to ensure new creations meet both creative ambitions and consumer demand. By testing with unbiased panels and allowing products to develop over years rather than months, Moosbrugger ensures each launch is built for lasting success.From Austria's deep culinary heritage to modern market challenges, this episode offers a rare behind-the-scenes look at a company balancing tradition, creativity, and global competitiveness—all while producing some of the world's most distinctive and delicious cheeses. Whether you're a cheese lover, food industry professional, or fan of entrepreneurial success stories, this episode will leave you hungry to taste the pine-covered perfection that's turning heads in Canada and beyond.https://www.kaese-moosbrugger.at/en/https://www.advantageaustria.org/ca/servicecenter/Buero-Toronto.en.html The Food Professor #podcast is presented by Caddle. About UsDr. Sylvain Charlebois is a Professor in food distribution and policy in the Faculties of Management and Agriculture at Dalhousie University in Halifax. He is also the Senior Director of the Agri-food Analytics Lab, also located at Dalhousie University. Before joining Dalhousie, he was affiliated with the University of Guelph's Arrell Food Institute, which he co-founded. Known as “The Food Professor”, his current research interest lies in the broad area of food distribution, security and safety. Google Scholar ranks him as one of the world's most cited scholars in food supply chain management, food value chains and traceability.He has authored five books on global food systems, his most recent one published in 2017 by Wiley-Blackwell entitled “Food Safety, Risk Intelligence and Benchmarking”. He has also published over 500 peer-reviewed journal articles in several academic publications. Furthermore, his research has been featured in several newspapers and media groups, including The Lancet, The Economist, the New York Times, the Boston Globe, the Wall Street Journal, Washington Post, BBC, NBC, ABC, Fox News, Foreign Affairs, the Globe & Mail, the National Post and the Toronto Star.Dr. Charlebois sits on a few company boards, and supports many organizations as a special advisor, including some publicly traded companies. Charlebois is also a member of the Scientific Council of the Business Scientific Institute, based in Luxemburg. Dr. Charlebois is a member of the Global Food Traceability Centre's Advisory Board based in Washington DC, and a member of the National Scientific Committee of the Canadian Food Inspection Agency (CFIA) in Ottawa. Michael LeBlanc is the president and founder of M.E. LeBlanc & Company Inc, a senior retail advisor, keynote speaker and now, media entrepreneur. He has been on the front lines of retail industry change for his entire career. Michael has delivered keynotes, hosted fire-side discussions and participated worldwide in thought leadership panels, most recently on the main stage in Toronto at Retail Council of Canada's Retail Marketing conference with leaders from Walmart & Google. He brings 25+ years of brand/retail/marketing & eCommerce leadership experience with Levi's, Black & Decker, Hudson's Bay, CanWest Media, Pandora Jewellery, The Shopping Channel and Retail Council of Canada to his advisory, speaking and media practice.Michael produces and hosts a network of leading retail trade podcasts, including the award-winning No.1 independent retail industry podcast in America, Remarkable Retail with his partner, Dallas-based best-selling author Steve Dennis; Canada's top retail industry podcast The Voice of Retail and Canada's top food industry and one of the top Canadian-produced management independent podcasts in the country, The Food Professor with Dr. Sylvain Charlebois from Dalhousie University in Halifax.Rethink Retail has recognized Michael as one of the top global retail experts for the fourth year in a row, Thinkers 360 has named him on of the Top 50 global thought leaders in retail, RTIH has named him a top 100 global though leader in retail technology and Coresight Research has named Michael a Retail AI Influencer. If you are a BBQ fan, you can tune into Michael's cooking show, Last Request BBQ, on YouTube, Instagram, X and yes, TikTok.Michael is available for keynote presentations helping retailers, brands and retail industry insiders explaining the current state and future of the retail industry in North America and around the world.
Mark Weisbrot and Francisco Rodríguez join us to discuss their Lancet article, co-authored with Silvio Rendón, "Effects of international sanctions on age-specific mortality: a cross-national panel data analysis," and their articles based on that research, "Sanctions can kill as many people as wars" (Financial Times), and "Rethink sanctions. They're killing as many people as war does" (LA Times). "The Moment of Truth" with Jeff Dorchen follows the interview. Check out Mark and Francisco's study, co-authored with Silvio Rendón: https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(25)00189-5/fulltext Check out Mark's article in the LA Times: https://www.latimes.com/opinion/story/2025-07-24/united-states-sanctions-deaths Check out Francisco's article at Financial Times: https://www.ft.com/content/99206b73-92c4-41f1-9677-d4a1e6fc78b1?accessToken=zwAGO8yGY2UgkdOZIGtzksRB8dOWd9Sh5vx4sQ.MEQCIFP6yeUhZIJ4mPS1-GjgdlEcQAaHOOh8YjxiUWaqlMAJAiB5JbhVt6_de4NuKcvk8TCwva2ZtyzJMBscOiQnyHKTiA&sharetype=gift&token=4d21afe8-c829-4682-8cd0-4ea688ff1ca7 (sorry about the long url) Help keep This Is Hell! completely listener supported and access bonus episodes by subscribing to our Patreon: https://www.patreon.com/thisishell Please rate and review This Is Hell! wherever you get your podcasts. It really helps the show ascend the algorithm to reach new listeners.
How does genetic testing help doctors treat patients? How accurate are private companies like 23andMe? Does knowing your genetic risk help people lead healthier lives or is it just a waste of time and money? Sophie had a bunch of questions about how genetic testing is used in everyday medical practice and Chris was here to answer! Become a supporter of our show today either on Patreon or through PayPal! Thank you! http://www.patreon.com/thebodyofevidence/ https://www.paypal.com/donate?hosted_button_id=9QZET78JZWCZE Email us your questions at thebodyofevidence@gmail.com. Editor: Robyn Flynn Theme music: “Fall of the Ocean Queen“ by Joseph Hackl Rod of Asclepius designed by Kamil J. Przybos Chris' book, Does Coffee Cause Cancer?: https://ecwpress.com/products/does-coffee-cause-cancer Obviously, Chris is not your doctor (probably). This podcast is not medical advice for you; it is what we call information. References: Studies evaluating the accuracy of Direct to Consumer genetic testing companies: Ng PC, Murray SS, Levy S, Venter JC. An agenda for personalized medicine. Nature. 2009 Oct 8;461(7265):724-6. doi: 10.1038/461724a. PMID: 19812653. Imai K, Kricka LJ, Fortina P. Concordance study of 3 direct-to-consumer genetic-testing services. Clin Chem. 2011 Mar;57(3):518-21. doi: 10.1373/clinchem.2010.158220. Studies looking at how knowing the results of genetic testing affect medical treatment and lifestyle factors. Mega JL, et al. Genetic risk, coronary heart disease events, and the clinical benefit of statin therapy: an analysis of primary and secondary prevention trials. Lancet. 2015 Jun 6;385(9984):2264-2271. doi: 10.1016/S0140-6736(14)61730-X Khera AV, Emdin CA, Drake I, Natarajan P, Bick AG, Cook NR, Chasman DI, Baber U, Mehran R, Rader DJ, Fuster V, Boerwinkle E, Melander O, Orho-Melander M, Ridker PM, Kathiresan S. Genetic Risk, Adherence to a Healthy Lifestyle, and Coronary Disease. N Engl J Med. 2016 Dec 15;375(24):2349-2358. doi: 10.1056/NEJMoa1605086. The Cochrane review and MI-GENES study which showed that genetic information did not change lifestyle behavior Hollands GJ, French DP, Griffin SJ, Prevost AT, Sutton S, King S, Marteau TM. The impact of communicating genetic risks of disease on risk-reducing health behaviour: systematic review with meta-analysis. BMJ. 2016 Mar 15;352:i1102. doi: 10.1136/bmj.i1102. Kullo IJ, et al. Incorporating a Genetic Risk Score Into Coronary Heart Disease Risk Estimates: Effect on Low-Density Lipoprotein Cholesterol Levels (the MI-GENES Clinical Trial). Circulation. 2016 Mar 22;133(12):1181-8. doi: 10.1161/CIRCULATIONAHA.115.020109
Send us a Text Message (please include your email so we can respond!)Episode 71! We continue talking about the articles from the CCR25 conference with FLUID or "A Crossover Trial of Hospital-Wide Lactated Ringer's Solution versus Normal Saline" published in NEJM 2025 by McIntyre et al and our old article is BICAR-ICU or "Sodium bicarbonate therapy for patients with severe metabolic acidaemia in the intensive care unit" by Jaber et al in Lancet 2018.FLUID: https://pubmed.ncbi.nlm.nih.gov/40503714/FLUID (NEJM): https://www.nejm.org/doi/10.1056/NEJMoa2416761BICAR-ICU: https://pubmed.ncbi.nlm.nih.gov/29910040/If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!
In this candid and wide-ranging conversation, Dr Jared Powell is joined once again by Professor Peter O'Sullivan, one of the most influential voices in musculoskeletal care. Pete unpacks the rationale and findings of the landmark RESTORE trial published in The Lancet, which provides some of the most compelling evidence to date for cognitive functional therapy (CFT) in people with chronic low back pain. He discusses how CFT works, its philosophical divergence from traditional “find-it, fix-it” approaches, and how it centres the patient's experience, goals, and context. You'll also hear: A simple explanation of the 3 pillars of CFT The real-world training model used in the RESTORE trial The importance of behaviour change, flare-up planning, and self-efficacy What to do when CFT “doesn't work” Pete's reflections on burnout, clinician support, and the importance of community A behind-the-scenes look at the Evolve Pain Care Academy: a new initiative to democratize pain education globally This episode is packed with practical insights, personal reflections, and a compelling vision for the future of musculoskeletal care. Register for The Complete Clinician waitlist here Key papers: Listen to me, learn from me. Slater et al 2022. The RESTORE trial 3 year follow-up Connect with Jared and guests: Jared on Instagram: @shoulder_physio Jared on X: @jaredpowell12 Evoolve Pain Care Pete X: @peteosullivanpt See our Disclaimer here: The Shoulder Physio - Disclaimer
A new study is challenging one of the most pervasive messages in health and fitness: the belief that 10,000 daily steps are needed to prolong life and prevent disease. Led by Professor Melody Ding at the University of Sydney and published in The Lancet, the study is the largest of its kind, analyzing data from more than 30 studies worldwide. Its findings suggest that significant health benefits may be achieved with as few as 7,000 steps a day—an attainable target for many who find 10,000 steps daunting. In this interview, Professor Ding discusses the scientific basis for rethinking our daily activity goals, how the research caught global attention, and what it means for public health recommendations moving forward. Peter Bowes speaks to Professor Ding to unpack what this shift in guidance could mean for millions tracking their steps around the world. PartiQlar supplementsEnhance your wellness journey with PartiQlar supplements. No magic formulas, just pure single ingredients, like NMN, L-Glutathione, Spermidine, Resveratrol, TMG and Quercetin. Get a 15% discount with the code MASTERAGING15 at PartiQlarEnergyBits algae snacksA microscopic form of life that could help us age better. Use code LLAMA for a 20 percent discountDisclaimer: This post contains affiliate links. If you make a purchase, I may receive a commission at no extra cost to you.Support the showThe Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.
Neste episódio, Vinícius Zofoli, médico intensivista e conteudista do Portal Afya, discute os resultados de um estudo clínico importante que comparou iniciar os DOAC em até 4 dias do AVC versus aguardar 7-12 dias do ictus. O estudo OPTIMAS, publicado recentemente no Lancet, muda a prática do intensivista no dia a dia. Aperte o play e ouça agora!Confira esse e outros posts no Portal Afya e siga nossas redes sociais!FacebookInstagramLinkedinTwitter
Neste episódio, Isabela Abud, médica cardiologista e editora de Cardiologia do Portal Afya, discute sobre o início da anticoagulação no paciente com acidente vascular cerebral isquêmico associado a fibrilação atrial, dúvida frequente o dia a dia do cardiologista. A especialista analisa o estudo OPTIMAS, publicado no Lancet, que teve como objetivo estabelecer a eficácia e segurança da anticoagulação precoce com um anticoagulante oral direto (DOAC) em pacientes com AVC isquêmico associado a FA. Aperte o play e ouça agora!Confira esse e outros posts no Portal Afya e siga nossas redes sociais!FacebookInstagramLinkedinTwitter
In Geneva, negotiators from 175 nations are trying to hammer out the first-ever legally binding treaty on plastic pollution. The urgency of the talks was underscored this week by a new study published in The Lancet. It calls plastics a “grave, growing and under-recognized danger to human and planetary health.” John Yang speaks with Tracey Woodruff, one of the study’s authors, to learn more. PBS News is supported by - https://www.pbs.org/newshour/about/funders
In Geneva, negotiators from 175 nations are trying to hammer out the first-ever legally binding treaty on plastic pollution. The urgency of the talks was underscored this week by a new study published in The Lancet. It calls plastics a “grave, growing and under-recognized danger to human and planetary health.” John Yang speaks with Tracey Woodruff, one of the study’s authors, to learn more. PBS News is supported by - https://www.pbs.org/newshour/about/funders
Eleanor Goldfield hosts this week's show. Her first guest, Shir Hever, explains what he describes as Israelis “zombie economy”, and its media establishment that isn't telling Israelis the truth about the genocide being perpetrated in nearby Gaza. Then Margaret Flowers returns to the program to discuss the astonishing death toll exacted by US/EU economic warfare against nations they deem hostile, from Venezuela to Iran. A recent study published in the Lancet medical journal estimated that these unilateral “sanctions” have claimed more than 500,000 lives worldwide each year, from malnutrition, increased infant mortality, unobtainable medical care, and other causes. Music-break information: “No Rest for the Weary” by the Blue Scholars The News That Didn't Make the News. Each week, co-hosts Mickey Huff and Eleanor Goldfield conduct in depth interviews with their guests and offer hard hitting commentary on the key political, social, and economic issues of the day with an emphasis on critical media literacy. The post Israel, a “Zombie” Economy? // US Economic Warfare has Killed Millions appeared first on KPFA.
Send us a textIn this podcast, we talk about the findings of a recent study published in The Lancet regarding the benefits of a plant-based diet for people with Inflammatory Bowel Disease (IBD). We discuss the significance of including more plant-based foods in the diet, the importance of fiber for gut health, and practical steps for gradually introducing fiber into the diet. We have been talking about including more fiber and plant based foods into the diet for a long time and many research studies support this! Takeaways-- A plant-based diet can significantly reduce the risk of developing Crohn's and ulcerative colitis.- Individuals with IBD may experience fewer hospitalizations and surgeries when following a plant-based diet.- The study included a large sample size, enhancing the reliability of its findings.- Incorporating plants into the diet is crucial for gut health.- Fiber intake is linked to reduced flare-ups in IBD patients.- A gradual approach to increasing fiber intake is recommended.- Soluble fibers are often better tolerated by those with IBD.- Support and guidance can help individuals transition to a more plant-based diet.- The importance of plants in nutrition has been consistently supported by research.Chapters:00:00- Introduction to the Plant-Based Diet Research02:25- Impact of Plant-Based Diet on IBD05:14- Understanding Fiber and Gut Health07:14- Practical Steps for Introducing Fiber09:35- Encouragement and Support for Dietary ChangesFollow us on instagram @crohns_and_colitis_dietitiansFollow us on youtube @thecrohnscolitisdietitiansWe love helping provide quality content on IBD nutrition and making it more accessible to all through our podcast, instagram and youtube channel. Creating the resources we provide comes at a significant cost to us. We dream of a day where we can provide even more free education, guidance and support to those with IBD like us. We need your support to do this. You can help us by liking episodes, sharing them on your social media, subscribing to you tube and telling others about us (your doctors, friends, family, forums/reddit etc). Can you do this for us? In return, I promise to continually level up what we do here.
C dans l'air l'invité du 6 août avec Xavier Coumoul, professeur de toxicologie et de biochimie à l'Université Paris Cité.À Genève, 180 pays entament dix jours de négociations sous l'égide de l'ONU pour tenter d'adopter le premier traité mondial visant à freiner la pollution plastique. Ce sommet intervient alors que la production mondiale de plastique bat des records : 400 millions de tonnes de déchets sont générées chaque année, dont près de 4 millions en France. Selon l'OCDE, ce volume pourrait tripler d'ici 2055, dans un contexte tendu où s'opposent défenseurs du recyclage, promoteurs d'une réduction à la source et lobbys industriels puissants.La pollution plastique dépasse désormais les sols et les océans : l'air est lui aussi contaminé. Comment les microplastiques pénètrent-ils dans notre organisme ? L'alimentation reste la principale voie d'exposition, mais l'inhalation gagne en importance, notamment en raison de la dégradation spontanée des matériaux dans nos environnements intérieurs. Dans un rapport récent publié par la revue médicale “The Lancet”, une trentaine de chercheurs et médecins établissent un lien direct entre plastique, maladies et mortalité. Ces particules de plastique sont associées à des inflammations et à des pathologies respiratoires, cardiovasculaires ou neurodégénératives.La production mondiale de déchets plastiques ne ralentit pas. 80 % des déchets marins proviennent de l'intérieur des terres, à l'image du “vortex plastique du Pacifique”, une immense zone d'ordures flottantes qui s'étend entre le Japon et les États-Unis sur une surface d'environ trois fois la France (1,6 million de km²). Chaque minute, l'équivalent d'un camion-poubelle est déversé dans les océans.Comment réduire la production mondiale de plastique ? Quels sont les pays les plus mauvais élèves ? Comment changer durablement nos modes de consommation ? Que peut-on réellement attendre des négociations en cours à Genève ?Xavier Coumoul, professeur de toxicologie et de biochimie à l'Université Paris Cité, décryptera les enjeux cruciaux des négociations en cours à Genève contre la pollution plastique et leurs impacts directs sur notre santé.
In this episode of The CommonHealth Live!, Dr. Christopher J.L. Murray, Director of the Institute for Health Metrics and Evaluation (IHME) and Stephanie Psaki, CSIS Global Health Policy Center Senior Adviser, will discuss IHME's new report on Financing Global Health, also released in a paper in The Lancet, and its implications for the way forward in a constrained financial environment. Who and which countries are those most affected by the sharp drop in development assistance for health between 2024 and 2025? How will recipient governments and other global stakeholders respond to fill the gaps? This event is made possible by the generous support of The Gates Foundation.
Clearing the FOG with co-hosts Margaret Flowers and Kevin Zeese
The Lancet, a renowned medical journal, recently published a groundbreaking report on the number of people who die each year as a result of economic sanctions primarily imposed by the United States. US economic wars have killed more than 560,000 people each year for the past ten years, over half of those killed are children five years of age and younger. This number is higher than the number of people who die in military conflicts. Clearing the FOG speaks with Sara Flounders, a co-founder of the Sanctions Kill campaign, about what sanctions are, how they kill, and why the United States wages economic warfare. For more information, visit PopularResistance.org.
A new review in the Lancet details what our dependence on plastics is costing human health. And one of the experts behind it hopes countries will heed his warnings ahead of negotiations toward a global plastics treaty.A 150-hectare wildfire bears down on small towns in eastern Newfoundland... and we hear from a councilor for a town where residents have been ordered to evacuate for the third time this summer.Plus...New technology helps scientists uncover the tattoos of a 2-thousand-year-old Siberian mummy. We hear from the author of the study - who just happens to be a traditional tattoo artist himself.As It Happens, the Monday edition. Radio that hopes to leave a lasting impression.
Thank you to everyone who tuned into my live video! Join me for my next live video in the app.* Plastics Cause Over $1.5 Trillion in ‘Health-Related Economic Losses' Per Year Globally: “Plastics are a grave, growing, and under-recognized danger to human and planetary health,” says a new study published in The Lancet. [More]* ‘Come and Take It': Texas Dems D… To hear more, visit egberto.substack.com
Ralph and the crew spend the whole hour with Omer Bartov, professor of Holocaust and genocide studies at Brown University, who grew up in a Zionist home, lived the first half of his life in Israel, served in the I.D.F. as a soldier and officer and is the author a New York Times op-ed entitled “I'm a Genocide Scholar. I Know It When I See It.” Plus, Ralph pays tribute to legendary Washington Post reporter, Morton Mintz.Omer Bartov is a professor of Holocaust and genocide studies at Brown University. He has written widely on modern Germany, France, the Holocaust, and representations of war and genocide. He is the author of the Mirrors of Destruction: War, Genocide, and Modern Identity, and the forthcoming book, Israel: What Went Wrong?, and he's penned a New York Times op-ed entitled “I'm a Genocide Scholar. I Know It When I See It.”I published an op-ed in November 2023, and I said there were war crimes, clearly, crimes against humanity, and this will become genocide if it's not stopped. And the Biden administration at the time did nothing. President Biden could have stopped that within two weeks. The Israeli military machine cannot function for more than two or three weeks without constant supply of munitions, without constant supply of financial help, and most importantly, without a diplomatic Iron Dome, especially in the Security Council.Professor Omer BartovIf you say that you are shutting down speech because of anti-Semitism, who are the people who are pushing that? It must be all kinds of Jewish interests that are pushing that. And in that sense, this false campaign against anti-Semitism – some of whose leaders are people with pretty good anti-Semitic credentials themselves – is the best way to raise, to promote and incite anti-Semitism.Professor Omer BartovThere's no moral responsibility, there's no empathy being shown, and much of the population shares that view. To me, as someone who was raised in Israel, spent half of my life there, served four years in the army, to see my own society (including some of my friends) show this kind of moral callousness is frankly quite heartbreaking. And I have to say, it's the result of a long process. It's not only a response to October 7th, it's the result of six decades of occupation, of thinking of Palestinians as not really people who have any right to have rights or any right to health, to security. And in that sense, that long-term occupation has corrupted much of Israeli society. And maybe the most surprising thing is that there's still extraordinary people there who are fighting against that, but their numbers are diminishing, not growing.Professor Omer BartovMorton Mintz was hands-down the greatest consumer reporter of his generation. He opened up one field after another because he had a special sense of newsworthiness that other reporters and editors didn't have. He opened up the coverage of the pharmaceutical industry. He opened up the coverage of the auto industry. And he did so with such formidable documentation and research that other reporters started following the same subject area. So he was a pioneer.Ralph NaderNews 8/1/25* Crusading environmental lawyer Steven Donziger has published a new report in the left-wing outlet Orinoco Tribune on the undercount of the dead in Gaza. In this piece, Donziger uses the statistical model laid out by the prestigious medical journal The Lancet in their 2024 study on the Israeli military campaign, which found the direct and indirect death toll could be as high as 186,000. The Lancet study found that as many as 732 Gazans died every day from these direct and indirect causes. Multiplied by the 594 days the conflict has dragged on, this would equate to a death toll of 434,800, or 20.7% of the enclave's population. As Donziger notes, “If the same level of killing and indirect death that took place in Gaza…happened in the United States proportional to population, roughly 70 million Americans would have been killed.”* In more Gaza news, the Guardian reports that, “On Saturday night, the…IDF…intercepted and boarded the Handala, an aid ship that attempted to reach Gaza as part of the Freedom Flotilla Coalition…According to the coalition, IDF soldiers beat and choked…labor activist Chris Smalls.” The severity of the attack on Christian Smalls – founder of the independent Amazon Labor Union (ALU) – caused international outcry. From the Guardian report, “Smalls was physically assaulted by seven uniformed individuals. They choked him and kicked him in the legs, leaving visible signs of violence on his neck and back.” The incident also drew criticism for another reason: Smalls was the only Black person on board the Handala. While 21 members of the Flotilla group were detained, in their words ”abducted,” “This level of force was not used.” It is unclear why this level of force was used against Smalls and Smalls alone, other than the color of his skin.* Yet more tragic news from Gaza concerns the death of Odeh Hadalin, the 31-year-old Palestinian activist and English teacher featured in the Oscar-winning documentary No Other Land. Al Jazeera reports that footage taken by Israeli human rights group B'Tselem “appears to show [Israeli settler Yinon] Levi opening fire on Hadalin during a confrontation in the village [of Umm al-Kheir, south of Hebron].” Levi, already sanctioned by the European Union and the United States over past attacks on Palestinians, reportedly told witnesses he was “glad about it.” Despite all of this, an Israeli court has released Levi on house arrest. Basel Adra, who co-directed No Other Land with Yuval Abraham, wrote “This is how Israel erases us — one life at a time.”* One positive development is in progress however. According to the Embassy of France in the United States, "France is prepared to fully recognize the State of Palestine, and will do so in September." French recognition of the Palestinian state, will If it ultimately comes to pass, have major ramifications on the world stage. While 147 member states of the United Nations have recognized Palestine, only 10 out of 27 EU countries have done so, mostly former Eastern Bloc states like Bulgaria, Hungary, Poland, and Romania, along with the former country of Czechoslovakia. The modern country of Slovakia has reaffirmed their recognition; Czechia has not. In 2024, several more European nations extended recognition, including Norway, Slovenia, Ireland and Spain. France however would tip the permanent members of the United Nations Security Council to a 3-2 majority in recognition of Palestine, along with Russia and China. Moreover, AP reports the United Kingdom is now saying they will “recognize a Palestinian state in September unless Israel agrees to a ceasefire in Gaza,” among other conditions. If this happens, The permanent members of the Security Council would be split 4-1, with the United States as the lone holdout. This would be nothing short of an international relations sea change on the question of Palestine.* In some more positive foreign policy news, Jeremy Corbyn's new party in the U.K. is getting started with a bang. According to the man himself, over 600,000 people have signed up to register with the new party, which describes itself as “a new kind of political party. One that is rooted in our communities, trade unions and social movements. One that builds power in all regions and nations. One that belongs to you.” Polls show this new party in the lead among Britons aged 18-24 and Corbyn leading Labour Party leader Keir Starmer by “Almost Every Metric,” among members of the rightwing populist Reform Party. That said, the Reform Party is still projected to win an overwhelming victory compared to all other parties in the next elections, though those are not expected to be held until 2029.* In Congress, Bernie Sanders forced a vote Wednesday on two new Senate resolutions to block arms transfers to Israel. Resolution 34 would “prohibit the U.S.-taxpayer financed $675.7 million sale of 201 MK 83 1,000-pound bombs; 4,799 BLU-110A/B General Purpose 1,000-pound bombs; 1,500 Joint Direct Attack Munition (JDAM) guidance kits for MK 83 bombs; 3,500 JDAM guidance kits for MK 83 bombs; and related logistics and technical support services,” while Resolution 41 would “prohibit the sale of tens of thousands of fully automatic assault rifles.” These resolutions got the support of 27 Senators, a new record and a majority of the Democratic Senate Caucus, but still far, far short of even a simple Senate majority. Perhaps a more portentous development is that Georgia Congresswoman Marjorie Taylor Greene this week became the first Republican in Congress to call the crisis in Gaza a “genocide,” according to the Hill. It remains to be seen whether this will help break the dam on that side of the aisle.* In New York City, new polling shows stunning results for Zohran Mamdani. The new poll conducted by Zenith Research and Public Progress Solutions shows Zohran dominating the 5-way race, earning 50% and beating out the other four candidates combined. Mamdani does even better in head-to-head matches against disgraced former Governor Andrew Cuomo and corruption-dogged incumbent Mayor Eric Adams. The crosstabs are even more astonishing. Despite the breathless and baseless accusations of antisemitism, Zohran is winning 67% of Jews under age 45 and a whopping 85% of men ages 18-34. This second number is key as Democrats struggle to attract young men. One warning sign: a recent Pew poll shows Republicans with an 18-point lead among men in the Gen Z cohort.* In an ominous challenge to the separation of church and state, the Hill reports President Donald Trump released a memo Monday allowing federal employees to “attempt to persuade co-workers about why their religious beliefs are ‘correct.'” This memo cites “crosses, crucifixes and mezuzah,” as displays of religious indicia that should not result in disciplinary action. This bizarre and constitutionally dubious policy seems likely to lead to workplace discord.* In more Trump news, CBS reports Trump has ousted “Two top Justice Department antitrust officials.” According to sources, two deputies to Assistant Attorney General Gail Slater, who leads DOJ antitrust efforts, were “placed on administrative leave last week and fired on Monday for insubordination.” These two figures are Roger Alford, principal deputy assistant attorney general, and Bill Rinner, deputy assistant attorney general and head of merger enforcement. It is not clear why exactly Alford and Rinner were pushed out, but there has apparently been substantial strife within the administration over the antitrust cases against T-Mobile and Hewlett Packard Enterprise. AAG Slater is also overseeing antitrust lawsuits against Capital One, Apple, Google, and other major companies.* Finally, Wired reports the small Pacific island nation of Tuvalu is planning the first migration of an entire country. Tuvalu, which could be completely submerged by rising sea levels within the next 25 years, is seeking to resettle 280 Tuvaluans in Australia each year. This climate-driven mass migration is a stark sign of things to come if the international community continues to dither or deny the reality of the oncoming climate catastrophe. Today Tuvalu, tomorrow the world.This has been Francesco DeSantis, with In Case You Haven't Heard. Get full access to Ralph Nader Radio Hour at www.ralphnaderradiohour.com/subscribe
Tune in for another episode of Give The People What They Want! with Zoe Alexandra, Indian journalist Prasanth R, and Roger McKenzie, international editor of Morning Star, as they discuss Israel's interception and abduction of the latest Freefom Flotilla “Handala”, far-right mobilizations in the UK, recently released State of Food Security and Nutrition in the World (SOFI) report, the importance of Emancipation Day in the UK, Lancet's report on sanctions as well as the conviction of former far-right President of Colombia Álvaro Uribe.
In this episode, we focus on the history of researchers discovering the clinical applicability of the IL 23/17 axis, with a particular emphasis on psoriasis, psoriatic arthritis and axial SpA · Intro 0:01 · In this episode 0:12 · Leonard Calabrese, DO, is listening! 0:54 · Recap of last episode 3:09 · Putting the pieces together 5:12 · Quick overview of this science heavy episode 6:11 · What is psoriasis? 7:26 · Immunosuppressants for psoriasis/ Throwing meds at people and seeing what happens 10:10 · In the modern world of 1986 – olive oil placebo trial 11:36 · A quick aside into fungi 12:35 · What kind of T-cells are involved here? 16:41 · The TH-1 hypothesis 18:20 · IL-23 and IL-17 are doing something 19:34 · Going back to the drawing board in 2004 20:00 · p40 + p19 = IL-23 21:00 · IL-23 via minicircle DNA in mice 23:05 · Brand new and shiny TH-17 25:23 · The family of IL-17 26:36 · What do we know about IL-17 and psoriasis? 27:10 · IL-17A vs IL-17F in mouse studies 27:35 · Finding the difference between IL-17A and IL-17F in humans 28:23 · What exactly is IL-17 doing? 29:30 · The articular manifestations of psoriatic arthritis 30:57 · Spondylarthritis and the IL 23/17 axis 33:56 · T-cells we haven't talked about 35:40 · Summary of this episode 39:08 · Thanks for listening 41:34 We'd love to hear from you! Send your comments/questions to Dr. Brown at rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum. References: Bashyam H. J Exp Med. 2007;doi:10.1084/jem.2042fta Bjerke R J. Acta Derm Venereol. 1982;PMID:6179355 Cargill M, et al. Am J Hum Genet. 2007;doi:10.1086/511051 Chan J R, et al. J Exp Med. 2006;doi:10.1084/jem.20060244 Cuthbert R J, et al. Ann Rheum Dis. 2019;doi:10.1136/annrheumdis-2019-215210 Ellis C N, et al. JAMA. 1986;doi:10.1001/jama.1986 Ettehadi P, et al. Clin Exp Immunol. 1994;doi:10.1111/j.1365-2249.1994.tb06244.x Furue M, et al. Int J Mol Sci. 2020;doi:10.3390/ijms21041275 Gooderham M J, et al. J Eur Acad Dermatol Venereol. 2018;doi:10.1111/jdv.14868 Lee E, et al. J Exp Med. 2004;doi:10.1084/jem.20030451 Leonardi C L, et al. Lancet. 2008;doi:10.1016/S0140-6736(08)60725-4 Mease P J, et al. Lancet. 2000;doi:10.1016/S0140-6736(00)02530-7 Menon B, et al. Arthritis Rheumatol. 2014;doi:10.1002/art.38376 Moos S, et al. J Invest Dermatol. 2019;doi:10.1016/j.jid.2019.01.006 Muelle W, et al. N Engl J Med. 1979;doi:10.1056/NEJM197909063011016 Papp K A, et al. Lancet. 2008;doi:10.1016/S0140-6736(08)60726-6 Reinhardt A, et al. Arthritis Rheumatol. 2016;doi:10.1002/art.39732 Sherlock J P, et al. Nat Med. 2012;doi:10.1038/nm.2817 Tribe H T. Mycologist. 1998;doi:10.1016/S0269-915X(98)80100-6 Yawalkar N, et al. J Invest Dermatol. 1998;doi:10.1046/j.1523-1747.1998.00446.x Zaba L C, et al. J Allergy Clin Immunol. 2009;doi:10.1016/j.jaci.2009.08.046 Disclosures: Brown reports no relevant financial disclosures.
Tony Heller is back after many years and we jump right into politics, climate and energy. We also get into the Big Beautiful Bill, red states, AI and the models of climate change, population reduction, centralized databases, covid and WW3. Then we talk about MAID, warp speed, Governments going bankrupt, magnetic pole shifts, automated meta analysis, software development, and editor of Lancet re research fraud. I am a lifelong environmentalist. I worked to get the Clean Air Act passed. I worked as a volunteer wilderness ranger I have degrees in Geology and Electrical Engineering, and worked on the design team of many of the world's most complex designs, including some which likely power your PC or Mac. I have worked as a contract software developer on climate and weather models for the US government. https://www.youtube.com/@TonyHeller https://x.com/TonyClimate https://realclimatescience.com/#gsc.tab=0 Become a Lord or Lady with 1k donations over time. And a Noble with any donation. Leave Serfdom behind and help Grimerica stick to 0 ads and sponsors and fully listener supported. Thanks for listening!! Help support the show, because we can't do it without ya. Support the show directly: https://grimericacbd.com/ CBD / THC Gummies and Tinctures http://www.grimerica.ca/support https://www.patreon.com/grimerica http://www.grimericaoutlawed.ca/support www.Rokfin.com/Grimerica https://www.eventbrite.com/e/experience-the-ultimate-hunting-adventure-in-alberta-canada-tickets-1077654175649?aff=ebdsshcopyurl&utm-campaign=social&utm-content=attendeeshare&utm-medium=discovery&utm-term=organizer-profile&utm-share-source=organizer-profile The Eh- List site. Canadian Propaganda Deconstruction https://eh-list.ca/ The Eh-List YouTube Channel: https://youtube.com/@theeh-list?si=d_ThkEYAK6UG_hGX Adultbrain Audiobook YouTube Channel: https://www.youtube.com/@adultbrainaudiobookpublishing https://grimericaoutlawed.ca/The newer controversial Grimerica Outlawed Grimerica Show Check out our next trip/conference/meetup - Contact at the Cabin www.contactatthecabin.com Our audio book website: www.adultbrain.ca www.grimerica.ca/shrooms and Micro Dosing Darren's book www.acanadianshame.ca Grimerica on Rumble: https://rumble.com/c/c-2312992 Join the chat / hangout with a bunch of fellow Grimericans Https://t.me.grimerica https://www.guilded.gg/i/EvxJ44rk Leave a review on iTunes and/or Stitcher: https://itunes.apple.com/ca/podcast/grimerica-outlawed http://www.stitcher.com/podcast/grimerica-outlawed Sign up for our newsletter https://grimerica.substack.com/ SPAM Graham = and send him your synchronicities, feedback, strange experiences and psychedelic trip reports!! graham@grimerica.com InstaGRAM https://www.instagram.com/the_grimerica_show_podcast/ Tweet Darren https://twitter.com/Grimerica Can't. Darren is still deleted. Purchase swag, with partial proceeds donated to the show: www.grimerica.ca/swag Send us a postcard or letter http://www.grimerica.ca/contact/ Episode ART - Napolean Duheme's site http://www.lostbreadcomic.com/ MUSIC https://brokeforfree.bandcamp.com/ - Something Old Felix's Site sirfelix.bandcamp.com - Should I
The incidence of early onset colorectal cancer (EOCRC) has been rising prompting the change in change in screening guidelines to 45 years of age for average risk patients. Join us for an in-depth discussion with guest speakers Dr. Andrea Cercek and Dr. Nancy You, where we provide a comprehensive look at the growing challenge of EOCRC. Hosts: - Dr. Janet Alvarez - General Surgery Resident at New York Medical College/Metropolitan Hospital Center - Dr. Wini Zambare – General Surgery Resident at Weill Cornell Medical Center/New York Presbyterian - Dr. Phil Bauer, Graduating Colorectal Surgical Oncology Fellow at Memorial Sloan Kettering Cancer Center - Dr. J. Joshua Smith MD, PhD, Chair, Department of Colon and Rectal Surgery at MD Anderson Cancer Center - Dr. Andrea Cercek - Gastrointestinal Medical Oncologist at Memorial Sloan Kettering Cancer Center - Dr. Y. Nancy You, MD MHSc - Professor, Department of Colon and Rectal Surgery at MD Anderson Cancer Center Learning objectives: - Describe trends in incidence of colorectal cancer, with emphasis on the rise of EOCRC. - Identify age groups and demographics most affected by EOCRC. - Summarize USPSTF recommendations for colorectal cancer screening. - Distinguish between screening methods (e.g., colonoscopy, FIT-DNA) and their sensitivity. - Understand treatment approaches for colon and rectal cancer (CRC) - Understand the role of mismatch repair (MMR) status in guiding treatment. - Outline the importance of genetic counseling and testing in young patients. - Discuss racial, ethnic, and socioeconomic disparities in CRC incidence and outcomes. - Describe the impact of cancer treatment on fertility and sexual health. - Review fertility preservation options. - Identify the value of integrated care teams for young CRC patients. References: 1. Siegel, R. L. et al. Colorectal Cancer Incidence Patterns in the United States, 1974–2013. JNCI J. Natl. Cancer Inst. 109, djw322 (2017). https://pubmed.ncbi.nlm.nih.gov/28376186/ 2. Abboud, Y. et al. Rising Incidence and Mortality of Early-Onset Colorectal Cancer in Young Cohorts Associated with Delayed Diagnosis. Cancers 17, 1500 (2025). https://pubmed.ncbi.nlm.nih.gov/40361427/ 3. Phang, R. et al. Is the Incidence of Early-Onset Adenocarcinomas in Aotearoa New Zealand Increasing? Asia Pac. J. Clin. Oncol.https://pubmed.ncbi.nlm.nih.gov/40384533/ 4. Vitaloni, M. et al. Clinical challenges and patient experiences in early-onset colorectal cancer: insights from seven European countries. BMC Gastroenterol. 25, 378 (2025). https://pubmed.ncbi.nlm.nih.gov/40375142/ 5. Siegel, R. L. et al. Global patterns and trends in colorectal cancer incidence in young adults. (2019) doi:10.1136/gutjnl-2019-319511. https://pubmed.ncbi.nlm.nih.gov/31488504/ 6. Cercek, A. et al. A Comprehensive Comparison of Early-Onset and Average-Onset Colorectal Cancers. J. Natl. Cancer Inst. 113, 1683–1692 (2021). https://pubmed.ncbi.nlm.nih.gov/34405229/ 7. Zheng, X. et al. Comprehensive Assessment of Diet Quality and Risk of Precursors of Early-Onset Colorectal Cancer. JNCI J. Natl. Cancer Inst. 113, 543–552 (2021). https://pubmed.ncbi.nlm.nih.gov/33136160/ 8. Standl, E. & Schnell, O. Increased Risk of Cancer—An Integral Component of the Cardio–Renal–Metabolic Disease Cluster and Its Management. Cells 14, 564 (2025). https://pubmed.ncbi.nlm.nih.gov/40277890/ 9. Muller, C., Ihionkhan, E., Stoffel, E. M. & Kupfer, S. S. Disparities in Early-Onset Colorectal Cancer. Cells 10, 1018 (2021). https://pubmed.ncbi.nlm.nih.gov/33925893/ 10. US Preventive Services Task Force. Screening for Colorectal Cancer: US Preventive Services Task Force Recommendation Statement. JAMA 325, 1965–1977 (2021). https://pubmed.ncbi.nlm.nih.gov/34003218/ 11. Fwelo, P. et al. Differential Colorectal Cancer Mortality Across Racial and Ethnic Groups: Impact of Socioeconomic Status, Clinicopathology, and Treatment-Related Factors. Cancer Med. 14, e70612 (2025). https://pubmed.ncbi.nlm.nih.gov/40040375/ 12. Lansdorp-Vogelaar, I. et al. Contribution of Screening and Survival Differences to Racial Disparities in Colorectal Cancer Rates. Cancer Epidemiol. Biomarkers Prev. 21, 728–736 (2012). https://pubmed.ncbi.nlm.nih.gov/22514249/ 13. Ko, T. M. et al. Low neighborhood socioeconomic status is associated with poor outcomes in young adults with colorectal cancer. Surgery 176, 626–632 (2024). https://pubmed.ncbi.nlm.nih.gov/38972769/ 14. Siegel, R. L., Wagle, N. S., Cercek, A., Smith, R. A. & Jemal, A. Colorectal cancer statistics, 2023. CA. Cancer J. Clin. 73, 233–254 (2023). https://pubmed.ncbi.nlm.nih.gov/36856579/ 15. Jain, S., Maque, J., Galoosian, A., Osuna-Garcia, A. & May, F. P. Optimal Strategies for Colorectal Cancer Screening. Curr. Treat. Options Oncol. 23, 474–493 (2022). https://pubmed.ncbi.nlm.nih.gov/35316477/ 16. Zauber, A. G. The Impact of Screening on Colorectal Cancer Mortality and Incidence: Has It Really Made a Difference? Dig. Dis. Sci. 60, 681–691 (2015). https://pubmed.ncbi.nlm.nih.gov/25740556/ 17. Edwards, B. K. et al. Annual report to the nation on the status of cancer, 1975-2006, featuring colorectal cancer trends and impact of interventions (risk factors, screening, and treatment) to reduce future rates. Cancer 116, 544–573 (2010). https://pubmed.ncbi.nlm.nih.gov/19998273/ 18. Cercek, A. et al. Nonoperative Management of Mismatch Repair–Deficient Tumors. New England Journal of Medicine 392, 2297–2308 (2025). https://pubmed.ncbi.nlm.nih.gov/40293177/ 19. Monge, C., Waldrup, B., Carranza, F. G. & Velazquez-Villarreal, E. Molecular Heterogeneity in Early-Onset Colorectal Cancer: Pathway-Specific Insights in High-Risk Populations. Cancers 17, 1325 (2025). https://pubmed.ncbi.nlm.nih.gov/40282501/ 20. Monge, C., Waldrup, B., Carranza, F. G. & Velazquez-Villarreal, E. Ethnicity-Specific Molecular Alterations in MAPK and JAK/STAT Pathways in Early-Onset Colorectal Cancer. Cancers 17, 1093 (2025). https://pubmed.ncbi.nlm.nih.gov/40227607/ 21. Benson, A. B. et al. Colon Cancer, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology. J. Natl. Compr. Cancer Netw. JNCCN 19, 329–359 (2021). https://pubmed.ncbi.nlm.nih.gov/33724754/ 22. Christenson, E. S. et al. Nivolumab and Relatlimab for the treatment of patients with unresectable or metastatic mismatch repair proficient colorectal cancer. https://pubmed.ncbi.nlm.nih.gov/40388545/ 23. Dasari, A. et al. Fruquintinib versus placebo in patients with refractory metastatic colorectal cancer (FRESCO-2): an international, multicentre, randomised, double-blind, phase 3 study. The Lancet 402, 41–53 (2023). https://pubmed.ncbi.nlm.nih.gov/37331369/ 24. Strickler, J. H. et al. 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H., Williams, L. J., Jack, W. J. L., Cameron, D. A. & Dixon, J. M. Breast-Conserving Surgery with or without Irradiation in Early Breast Cancer. N. Engl. J. Med. 388, 585–594 (2023). https://pubmed.ncbi.nlm.nih.gov/36791159/ 30. Jacobsen, R. L., Macpherson, C. F., Pflugeisen, B. M. & Johnson, R. H. Care Experience, by Site of Care, for Adolescents and Young Adults With Cancer. JCO Oncol. Pract. (2021) doi:10.1200/OP.20.00840. https://pubmed.ncbi.nlm.nih.gov/33566700/ 31. Ruddy, K. J. et al. Prospective Study of Fertility Concerns and Preservation Strategies in Young Women With Breast Cancer. J. Clin. Oncol. (2014) doi:10.1200/JCO.2013.52.8877. https://pubmed.ncbi.nlm.nih.gov/24567428/ 32. Su, H. I. et al. Fertility Preservation in People With Cancer: ASCO Guideline Update. J. Clin. Oncol. 43, 1488–1515 (2025). https://pubmed.ncbi.nlm.nih.gov/40106739/ 33. Smith, K. L., Gracia, C., Sokalska, A. & Moore, H. Advances in Fertility Preservation for Young Women With Cancer. Am. Soc. Clin. Oncol. Educ. Book 27–37 (2018) doi:10.1200/EDBK_208301. https://pubmed.ncbi.nlm.nih.gov/30231357/ 34. Blumenfeld, Z. How to Preserve Fertility in Young Women Exposed to Chemotherapy? The Role of GnRH Agonist Cotreatment in Addition to Cryopreservation of Embrya, Oocytes, or Ovaries. The Oncologist 12, 1044–1054 (2007). 35. Bhagavath, B. The current and future state of surgery in reproductive endocrinology. Curr. Opin. Obstet. Gynecol. 34, 164 (2022). 36. Ribeiro, R. et al. Uterine transposition: technique and a case report. Fertil. Steril. 108, 320-324.e1 (2017). 37. Yazdani, A., Sweterlitsch, K. M., Kim, H., Flyckt, R. L. & Christianson, M. S. Surgical Innovations to Protect Fertility from Oncologic Pelvic Radiation Therapy: Ovarian Transposition and Uterine Fixation. J. Clin. Med. 13, 5577 (2024). 38. Holowatyj, A. N., Eng, C. & Lewis, M. A. Incorporating Reproductive Health in the Clinical Management of Early-Onset Colorectal Cancer. JCO Oncol. Pract. 18, 169–172 (2022). ***Behind the Knife Colorectal Surgery Oral Board Audio Review: https://app.behindtheknife.org/course-details/colorectal-surgery-oral-board-audio-review Please visit https://behindtheknife.org to access other high-yield surgical education podcasts, videos and more. If you liked this episode, check out our recent episodes here: https://app.behindtheknife.org/listen
Are your current stroke interventions in line with the latest clinical data? Dr. Blaise Baxter, interventional radiologist at Sutter Health, and Dr. Jim Milburn, interventional neuroradiologist at the Ochsner Health, join host Dr. Michael Barraza to discuss the latest advancements in stroke interventions. --- This podcast is supported by: Imperative Carehttps://imperativecare.com/stroke/zoom-stroke-solution/ --- SYNPOSIS The episode begins with a discussion on the different pathways to becoming a neurointerventionalist, emphasizing why interventional radiologists are uniquely equipped for this transition. They dive into cutting-edge stroke interventions, sharing key takeaways from major trials on large core and medium vessel occlusions. Dr. Baxter and Dr. Milburn highlight the HERMES trial, which showed that endovascular thrombectomy led to beneficial effects on patients with anterior circulation occlusion. They then cover the BAOCHE trial, which showed better functional outcomes with thrombectomy over medical therapy. Milburn and Baxter also share their perspectives on the shifting role of perfusion imaging and why the field may be moving beyond it. To close the discussion, the doctors underscore the powerful impact of rehabilitation in driving patient recovery, and stress the ongoing need for innovation and improved training in the field of neurointerventional radiology. --- TIMESTAMPS 00:00 - Introduction06:18 - Training and Certification in Neurointervention13:11- Large Core Trials and Their Impact19:42 - CT Perfusion and Treatment Decisions29:45 - Understanding Stroke Scale Scores and ICAD30:31 - Thrombectomy Trials and Treatment Strategies34:48 - Challenges in Randomizing Patients for Trials44:25 - Advancements in Robotics and Stroke Treatment51:37 - Future Directions in Stroke Rehabilitation53:11 - Global Thrombectomy Adoption and Training --- RESOURCES Hermes trial: Goyal M, Menon BK, van Zwam WH, et al. Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials. Lancet. 2016;387(10029):1723-1731. doi:10.1016/S0140-6736(16)00163-X BAOCH trial: Jovin TG, Li C, Wu L, et al. Trial of Thrombectomy 6 to 24 Hours after Stroke Due to Basilar-Artery Occlusion. N Engl J Med. 2022;387(15):1373-1384. doi:10.1056/NEJMoa2207576
With July upon us and bad decision season (mercifully) over, Leah, Kate and Melissa take a step back to recap this year's SCOTUS term. They highlight some of the overarching themes, break down the biggest opinions, and look back at the moments they'll remember forever–whether they want to or not. Hosts' favorite things:Melissa: KBJ's footnote 12 in Stanley v. City of Sanford, Florida; Seven Chaotic Months in the Life of a New Federal Judge, Emily Bazelon and Mattathias Schwartz (NYT); This Is the Real Impact of the Supreme Court's Planned Parenthood Decision, Linda Greenhouse (NYT); When Rational Basis Review Bit (HLR)Leah: A New Kind of Judicial Supremacy, Steve Vladeck (One First); With the Big, Beautiful Bill, You Can Now Sponsor a Billionaire of Your Choosing, Alexandra Petri (Atlantic); Samuel Alito Takes Pride in Gay-Bashing, Elie Mystal (The Nation); A Court Without the Range, Sherrilyn Ifill (Sherrilyn's Newsletter); ‘A Culture of Disdain': The Supreme Court's Actions Speak Louder Than Its Words, Kate Shaw (NYT); Andor (Disney+); Virgin, Lorde; Trump FragrancesKate: Trump's Big Win in His Escalating War on the Press, Bob Bauer (Executive Functions); USAID study (The Lancet); Is the Supreme Court the Best Way to Get Justice? Alexis Coe (NYT); Unbearable: Five Women and the Perils of Pregnancy in America, Irin Carmon; We the People: A History of the U.S. Constitution, Jill Lepore Get tickets for STRICT SCRUTINY LIVE – The Bad Decisions Tour 2025! 10/4 – ChicagoLearn more: http://crooked.com/eventsOrder your copy of Leah's book, Lawless: How the Supreme Court Runs on Conservative Grievance, Fringe Theories, and Bad VibesFollow us on Instagram, Threads, and Bluesky
Did your high school health teacher ever try to teach you the risks of sex by making you carry around an egg and pretend it was a baby? These days, the pretending isn't as much of a stretch. Lots of schools are opting to use robotic babies that cry throughout the day and night just like a real infant. In this episode, we follow two teenage girls over the course of 48 hours with the “babies,” and their conclusions surprise us! We also revisit the story after an eye-opening study in The Lancet that shed new light on our reporting. ⭐️ Versions of this episode originally aired on March 1, 2015 and November 16, 2016 and the story is a favorite from the LST archives. It's also part of our ongoing Sex & Parenthood series. We've been airing a few episodes from the series over the next few weeks, while we gear up for our next batch of new episodes. You can find the full series here. … Join LST+ for community and access to You Know What, another show in the Longest Shortest universe! Follow us on Instagram Website: longestshortesttime.com Learn more about your ad choices. Visit megaphone.fm/adchoices
For decades, the great fear was overpopulation. Now it's the opposite. How did this happen — and what's being done about it? (Part one of a three-part series, “Cradle to Grave.”) SOURCES:Matthias Doepke, professor of economics at the London School of Economics.Amy Froide, professor of history at the University of Maryland, Baltimore County.Diana Laird, professor of obstetrics and gynecology at the University of California, San Francisco.Catherine Pakaluk, professor of economics at The Catholic University of America. RESOURCES:"Fertility Rate, Total for the United States," (Federal Reserve Bank of St. Louis, 2025)."Global fertility in 204 countries and territories, 1950–2021, with forecasts to 2100: a comprehensive demographic analysis for the Global Burden of Disease Study 2021," (The Lancet, 2024)."Suddenly There Aren't Enough Babies. The Whole World Is Alarmed." by Greg Ip and Janet Adamy (The Wall Street Journal, 2024)."Taxing bachelors and proposing marriage lotteries – how superpowers addressed declining birthrates in the past," by Amy Froide (University of Maryland, 2021)."Is Fertility a Leading Economic Indicator?" by Kasey Buckles, Daniel Hungerman, and Steven Lugauer (National Bureau of Economic Research, 2018).The King's Midwife: A History and Mystery of Madame du Coudray, by Nina Rattner Gelbart (1999).The Population Bomb, by Paul Ehrlich (1970)."An Economic Analysis of Fertility," by Gary Becker (National Bureau of Economic Research, 1960). EXTRAS:"What Will Be the Consequences of the Latest Prenatal-Testing Technologies?" by Freakonomics Radio (2011).