Podcasts about Lancet

In July 2023, the ACOG released a Practice Advisory stating, “Based on data on the benefit of adjunct HPV vaccination, ACOG recommends adherence to the current Centers for Disease Control and Prevention (CDC) recommendations for vaccinations of individuals aged 9–26 years, and to consider adjuvant HPV vaccination for immunocompetent previously unvaccinated people aged 27–45 years who are undergoing treatment for CIN 2+”. The possible beneficial effect of peri-treatment HPV vaccination goes back to the early 2010s. But science is always changing, and MEDICINE MOVES FAST. In September 2025, the Lancet's Obstetrics, Gynecology, and Women's Health journal published the VACCIN trial to test that guidance. These authors found that, “Although previous studies, including meta-analyses and observational studies, have shown that adjuvant HPV vaccination reduces the recurrence of cervical dysplasia after surgical treatment, our trial suggests that adjuvant HPV vaccination is not effective in reducing the recurrence of CIN 2–3 lesions, contradicting the conclusions of previous works”. They have also called for a REVISION to prior guidance. This is FASCINATING. Listen in for details. 1. ACOG PA July 2023, “Adjuvant Human Papillomavirus Vaccination for Patients Undergoing Treatment for Cervical Intraepithelial Neoplasia 2+”2. Adjuvant prophylactic human papillomavirus vaccination for prevention of recurrent high-grade cervical intraepithelial neoplasia lesions in women undergoing lesion surgical treatment (VACCIN): a multicentre, phase 4 randomised placebo-controlled trial in the Netherlands: https://www.sciencedirect.com/science/article/pii/S305050382500007X#:~:text=To%20our%20knowledge%2C%20this%20is,the%20conclusions%20of%20previous%20works.STRONG COFFEE PROMO: 20% Off Strong Coffee Company https://strongcoffeecompany.com/discount/CHAPANOSPINOBG

Join the Behind the Knife Surgical Oncology Team as we discuss the nuances in the work up and management of patients with pheochromocytomas. Hosts: Timothy Vreeland, MD, FACS (@vreelant) is an Assistant Professor of Surgery at the Uniformed Services University of the Health Sciences and Surgical Oncologist at Brooke Army Medical Center. Daniel Nelson, DO, FACS (@usarmydoc24) is Surgical Oncologist/HPB surgeon at Kaiser LAMC in Los Angeles. Lexy (Alexandra) Adams, MD, MPH (@lexyadams16) is a 2ndYear Surgical Oncology fellow at MD Anderson. Beth (Elizabeth) Barbera, MD (@elizcarpenter16) is a General Surgery physician in the United States Air Force station at RAF Lakenheath. Joe (Joseph) Broderick, MD, MA (@joebrod5) is a General Surgery research resident between his second and third year at Brooke Army Medical Center. Galen Gist, MD (@gistgalen) is a General Surgery research resident between his second and third year at Brooke Army Medical Center. Learning Objectives: 1)    Review the presentation of patients with pheochromocytomas.  2)    Review the work up of patients with pheochromocytomas.  3)    Review the treatment of patients with pheochromocytomas.  4)    Review the surveillance of patients with pheochromocytomas.  References used in the making of this episode: Patel D. Surgical approach to patients with pheochromocytoma. Gland Surg. 2020;9(1):32-42. doi:10.21037/gs.2019.10.20. PMID: 32206597; PMCID:PMC7082266.   Eisenhofer G, Lenders JW, Siegert G, et al. Plasma methoxytyramine: a novel biomarker of metastatic pheochromocytoma and paraganglioma in relation to established risk factors of tumour size, location and SDHB mutation status. Eur J Cancer. 2012;48(11):1739-1749. doi:10.1016/j.ejca.2011.07.016. PMID:22036874; PMCID: PMC3372624.   Lenders JWM, Eisenhofer G, Mannelli M, Pacak K. Phaeochromocytoma. Lancet. 2005;366(9486):665-675. doi:10.1016/S0140-6736(05)67139-5.   Vicha A, Musil Z, Pacak K. Genetics of pheochromocytoma and paraganglioma syndromes: new advances and future treatment options. Curr Opin Endocrinol Diabetes Obes. 2013;20(3):186-191. doi:10.1097/MED.0b013e32835fcc45. PMID: 23481210; PMCID: PMC4711348. https://pubmed.ncbi.nlm.nih.gov/23481210/ Dickson PV, Alex GC, Grubbs EG, et al. Posterior retroperitoneoscopic adrenalectomy is a safe and effective alternative to transabdominal laparoscopic adrenalectomy for pheochromocytoma. Surgery. 2011;150(3):452-458. doi:10.1016/j.surg.2011.07.004. https://pubmed.ncbi.nlm.nih.gov/21878230/ Lei K, Wang X, Yang Z, et al. Comparison of the retroperitoneal laparoscopic adrenalectomy versus transperitoneal laparoscopic adrenalectomy for large (≥6 cm) pheochromocytomas: a single-centre retrospective study. Front Oncol. 2023;13:1043753. doi:10.3389/fonc.2023.1043753. PMID: 36910608; PMCID: PMC9992891. https://pubmed.ncbi.nlm.nih.gov/36910608/ Please visit https://behindtheknife.org to access other high-yield surgical education podcasts, videos and more.   If you liked this episode, check out our recent episodes here: https://behindtheknife.org/listen Behind the Knife Premium: General Surgery Oral Board Review Course: https://behindtheknife.org/premium/general-surgery-oral-board-review Trauma Surgery Video Atlas: https://behindtheknife.org/premium/trauma-surgery-video-atlas Dominate Surgery: A High-Yield Guide to Your Surgery Clerkship: https://behindtheknife.org/premium/dominate-surgery-a-high-yield-guide-to-your-surgery-clerkship Dominate Surgery for APPs: A High-Yield Guide to Your Surgery Rotation: https://behindtheknife.org/premium/dominate-surgery-for-apps-a-high-yield-guide-to-your-surgery-rotation Vascular Surgery Oral Board Review Course: https://behindtheknife.org/premium/vascular-surgery-oral-board-audio-review Colorectal Surgery Oral Board Review Course: https://behindtheknife.org/premium/colorectal-surgery-oral-board-audio-review Surgical Oncology Oral Board Review Course: https://behindtheknife.org/premium/surgical-oncology-oral-board-audio-review Cardiothoracic Oral Board Review Course: https://behindtheknife.org/premium/cardiothoracic-surgery-oral-board-audio-review Download our App: Apple App Store: https://apps.apple.com/us/app/behind-the-knife/id1672420049 Android/Google Play: https://play.google.com/store/apps/details?id=com.btk.app&hl=en_US

Dr. Kiran Thakur talks with Dr. Ava Easton about the World Health Organization's technical brief on encephalitis.  Read the related article in The Lancet.  Disclosures can be found at Neurology.org.     

We've talked about eco-anxiety before on Do You Really Know, and it's real. A survey published in the Lancet in December 2021 found that 75% of young people thought the future was frightening. But others are preaching a more positive outlook, with cautious climate optimism looking set to be a trend in 2023. While our fears around the climate crisis are justified and useful, if they paralyse us out of doing anything, those feelings of hopelessness are inevitable. Psychologists call it “learned helplessness”. What cause is there for optimism? What are the arguments against climate optimism? In under 3 minutes, we answer your questions! To listen to more episodes, click here: ⁠Should I walk 10000 steps a day?⁠ ⁠What is a vertiport?⁠ ⁠What is productivity paranoia?⁠ A Bababam Originals podcast. Written and produced by Joseph Chance. First Broadcast: 20/1/2023 Learn more about your ad choices. Visit megaphone.fm/adchoices

Donate (no account necessary) | Subscribe (account required) Join Bryan Dean Wright, former CIA Operations Officer, as he dives into today's top stories shaping America and the world. In this episode of The Wright Report, we cover the federal government shutdown, Pete Hegseth's blunt message to America's generals, new immigration updates from Chicago to Central America, and surprising global research on obesity. From furloughs in Washington to fat generals at the Pentagon, today's brief connects politics, security, and science shaping America's future.   Federal Government Shutdown Begins: Negotiations collapsed after Democrats demanded $1 trillion for health care tied to Biden's immigration surge. Trump warned, “We can do things during the shutdown that are irreversible,” and began cutting federal workers, including 100 FBI agents. Essential services like Social Security remain open, while departments like Labor shutter. Bryan notes, “This shutdown is ultimately about an argument I thought we settled last November.”   Pete Hegseth Calls Out Fat Generals: The Secretary of War unveiled a 10-point plan to toughen the military, starting with weight and fitness standards for all ranks. “It is tiring to look out… at any formation and see fat troops,” Hegseth said. The plan includes tougher boot camp, one combat standard for men and women, and no more promotions based on quotas. Trump joked, “Pete gave a great speech… but I don't want him to get so good I can't go on after that.”   Immigration Updates from Chicago to Central America: Four leftist protesters attacked an ICE facility in Chicago, one threatening, “I'll f------ kill you right now.” In Portland, illegals shined lasers at a CBP helicopter. In Iowa, ICE arrested a school superintendent who was in the country illegally and registered to vote. Meanwhile, Bloomberg reports migrants are sending record remittances home — $161 billion projected this year — fearing deportation. Bryan says, “Migrants are getting while the getting is good.”   Obesity Campaigns Fail Worldwide: A new Lancet study found that none of 17 childhood obesity programs worked, even with parental training and nutrition education. French researchers concluded rising caloric intake is the real driver, echoing why drugs like Ozempic work by cutting appetite. Bryan quips, “I put a new picture of Pete Hegseth on my fridge. I've already lost five pounds.”   "And you shall know the truth, and the truth shall make you free." - John 8:32     Keywords: federal government shutdown 2025, Trump irreversible budget cuts quote, FBI agents fired shutdown, Pete Hegseth fat generals 10 point plan, military fitness standards women combat, Chicago ICE attack leftist protesters, Portland illegals laser CBP helicopter, Iowa illegal superintendent voter registration, migrant remittances $161 billion Bloomberg, Lancet obesity study children, French study caloric intake obesity, Ozempic Wegovy appetite suppression

In this episode of the Let's Talk Brain Health Podcast, we welcome Dr. Kellyann Niotis, MD, the world's first fellowship-trained preventive neurologist, who shares her insights on early detection and risk reduction for neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Lewy body dementia. Dr. Niotis discusses the emerging field of preventive neurology, the role of blood biomarkers and genetic testing, and the importance of lifestyle choices in maintaining brain health. She also highlights the impact of cholesterol management, sleep studies, and the significance of personalized care approaches. Join us as we dive into a comprehensive discussion about the future of brain health and the proactive steps we can take today for healthier brains tomorrow.00:00 Introduction to Dr. Kellyann Niotis, MD02:47 What is Preventive Neurology?06:08 The Role of Biomarkers in Early Detection13:52 Lifestyle Modifications and Brain Health17:12 Cholesterol and Brain Health24:15 The Impact of Statins on Cognition26:05 Underutilized Tools in Brain Health30:11 Rapid Fire Questions and Final ThoughtsResourcesConnect with Kellyann on Instagram @drkellyannniotis Visit her website ​​and learn more about her new clinic on their websiteResearchLearn more about the research-informed brain health risks mentioned in this episode from the “Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission” ReportRead more about Dr. Lisa Misconi's research on how estrogen receptors are unregulated in perimenopause in this research article 

Die Themen in den Wissensnachrichten: +++ Umwandlung von Zellen für Befruchtung gelungen +++ Yoga kann bei Senioren zu Stürzen führen +++ Paradiesvögel tanzen sportlich zur Paarung +++**********Weiterführende Quellen zu dieser Folge:Induction of experimental cell division, Nature Communications, 30. September 2025The effect of an Iyengar yoga-based exercise programme on falls, The Lancet, 23. September 2025Dancing male riflebirds create a dynamic sensory trajectory, Current Biology, 29. September 2025Neue Chance für den Feldhamster in Sachsen, 1. Oktober 2025Adaptations in wing morphology, eLife, 30. September 2025Alle Quellen findet ihr hier.**********Ihr könnt uns auch auf diesen Kanälen folgen: TikTok und Instagram .

Welcome to Ozempic Weightloss Unlocked, where we dive into the latest breakthroughs and controversies surrounding Ozempic, its medical use, and its impact on everyday wellness.The big headline this month is the arrival of a new pill form of semaglutide, the main ingredient in Ozempic. According to The New England Journal of Medicine, people who took this daily pill lost almost 14 percent of their body weight over 64 weeks, compared to just 2 percent for those on a placebo. Fifty percent of the patients shed at least 15 percent of their weight, with nearly a third losing 20 percent or more. Novo Nordisk, the company that makes Ozempic, announced even stronger results for those who stuck to their treatment plan, with close to 17 percent average weight loss. This pill, pending approval, could be a game changer for people who prefer not to take injections.On the injectable front, clinical trials featured in The Lancet indicate that a higher 7.2 milligram weekly dose of semaglutide in adults without diabetes led to almost 19 percent average weight loss, higher than what's seen with lower doses. These numbers highlight ongoing efforts to increase the effectiveness of Ozempic for those struggling with obesity.Yet, it's crucial to balance these promising results with real-world insights. The Mayo Clinic and NYU Langone Health recently compared Ozempic's results to traditional weight loss surgery, like gastric bypass and sleeve gastrectomy. Their research revealed that surgery is five times more effective than GLP-1 drugs such as Ozempic, with surgical patients losing an average of 58 pounds after two years versus just 12 pounds for those on the drug for six months. Experts also noted that only 30 percent of patients stick with GLP-1 drugs for longer than a year, and real-world weight loss may be lower than trial results suggest. Surgery, however, isn't without its risks, including potential infections, blood clots, and hernias, and requires strict diet and lifestyle changes afterward.Turning to genetics, Cleveland Clinic research shows that the effectiveness of Ozempic may depend on your DNA. A specific variant in the Neurobeachin gene seems to make some people much more responsive to these medications, leading to 82 percent higher odds of substantial weight loss. This new insight could help doctors tailor treatments so patients get therapies most suited to their genetic profile.Lifestyle stakes are high, and so are concerns about side effects and safety. Recent studies report that Ozempic may cause severe conditions such as gastroparesis, bowel blockages, pancreatic and kidney injuries, and vision problems. Even hair loss is emerging as a potentially significant side effect, especially for women—according to recent findings, female users experienced about twice the rate of hair loss compared to those not using Ozempic.Because of these risks, there are currently over two thousand active lawsuits against Novo Nordisk and other GLP-1 manufacturers, with ongoing multidistrict litigation. These lawsuits allege that the companies did not give enough warning about the dangers, and some patients claim life-changing or life-threatening complications.Compounded GLP-1 drugs, made in pharmacies rather than by pharmaceutical companies, became popular when Ozempic was in short supply. However, the FDA warns that compounded drugs can be risky because they're not evaluated for safety or effectiveness. While the shortage has officially ended, compounded formulations remain in circulation.If you are considering Ozempic—whether as a pill, injection, or a compounded version—talk with your healthcare provider and review your health history, genetic background, and lifestyle goals. Widespread interest has led to changing availability, promising new forms, and more transparent labeling, especially after recent updates about kidney and pancreatic risks.To sum up, Ozempic continues to make waves as both a treatment for diabetes and a potent tool for weight loss. With fresh news about new pill forms, higher effective doses, genetic influences, and ongoing legal cases, it's important to stay informed and make choices based on both science and your personal health needs.Thanks for tuning in to Ozempic Weightloss Unlocked. Don't forget to subscribe to stay up to date on the latest developments. This has been a Quiet Please production, for more check out quiet please dot ai. Some great Deals https://amzn.to/49SJ3QsFor more check out http://www.quietplease.aiThis content was created in partnership and with the help of Artificial Intelligence AI

Professors Guy Brusselle and Celeste Porsbjerg join us to discuss their recent Series papers on asthma, which will be featured in a cross journal project with The Lancet, published to coincide with a Lancet journal session on asthma at ERS in Amsterdam. The Series aims to provide an overview of recent research advances related to asthma; to provide new insights into the genetics, prevention and risk factors for asthma; review advances arising as a result of the use of monoclonal antibody therapeutics; and assess remission in adult patients. Late breaking research will also be included within the journal session and linked to the Series.Continue this conversation on social!Follow us today at...https://thelancet.bsky.social/https://instagram.com/thelancetgrouphttps://facebook.com/thelancetmedicaljournalhttps://linkedIn.com/company/the-lancethttps://youtube.com/thelancettv

Across healthcare, new technologies often land in the hands of nurses without their input, adding complexity instead of easing it. In the age of artificial intelligence, more than ever, leaving nurses out of the design process risks creating tools that miss the mark, fail to build trust, threaten safety and security, and can add to the very burdens they're meant to relieve.  In this episode of our AI in Play series, we meet Ryannon Frederick, MS, RN, System Chief Nursing Officer at Mayo Clinic, who has restructured nursing leadership teams to ensure nurses identify the problems, co-develop the solutions, and remain partners from design through implementation and testing. Frederick shares how this “for nurses, by nurses” model is transforming innovation at Mayo, making nursing work visible, rebuilding trust in technology, and delivering tools like ambient documentation and nurse virtual assistants that give time back to patients and strengthen the workforce.  Find this episode's resources at www.seeyounowpodcast.com, and for more information on the podcast bundles, visit ANA's Innovation Website at:  https://www.nursingworld.org/practice-policy/innovation/education/.  Have questions for the SEE YOU NOW team? Feedback? Future episode ideas?   Contact us at: hello@seeyounowpodcast.com.    Resources  Enabling nurses' engagement in the design of healthcare technology – Core competencies and requirements: A qualitative study (2024) BMC Nursing. https://www.sciencedirect.com/science/article/pii/S2666142X23000541?via%3Dihub  Impact of Bottom-Up Cocreation of Nursing Technological Innovations: Explorative Interview Study Among Hospital Nurses and Managers (2025).JMIR. https://humanfactors.jmir.org/2025/1/e60543/  Global prevalence and contributing factors of nurse burnout: an umbrella review of systematic review and meta-analysis. (2025) BMC Nursing. https://bmcnurs.biomedcentral.com/articles/10.1186/s12912-025-03266-8  Documentation Burden in Nursing and Its Role in Clinician Burnout Syndrome. (2022) ACI.  https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0042-1757157  Addressing burnout in the healthcare workforce: current realities and mitigation strategies. (2024) The Lancet. https://www.thelancet.com/journals/lanepe/article/PIIS2666-7762(24)00128-5/fulltext 

Un nouvel épisode du Pharmascope est maintenant disponible et on termine notre série d'épisodes sur les troubles neurocognitifs majeurs. Dans ce 76ème épisode, Nicolas, Sébastien, Isabelle et leur invité discutent du traitement pharmacologique de la démence.  Les objectifs pour cet épisode sont: Expliquer les bénéfices et les risques associés aux traitements pharmacologiques des troubles neurocognitifs Discuter du suivi de l'efficacité et de l'innocuité des traitements utilisés dans les troubles neurocognitifs Comparer les avantages et inconvénients des différents agents utilisés dans le traitement des troubles neurocognitifs   Ressources pertinentes en lien avec l'épisode Revues systématiques Birks JS, Harvey RJ. Donepezil for dementia due to Alzheimer's disease. Cochrane Database Syst Rev. 2018;6:CD001190. Birks JS, Evans JG. Rivastigmine for Alzheimer's disease. Cochrane Database Syst Rev. 2015;4:CD001191. McShane R et coll. Memantine for dementia. Cochrane Database Syst Rev. 2019;3:CD003154. Consensus canadien sur la démence Ismail Z et coll. Recommendations of the 5th Canadian Consensus Conference on the diagnosis and treatment of dementia. Alzheimers Dement. 2020;16:1182-95. Commission du Lancet Livingston G et coll. Dementia prevention, intervention, and care: 2020 report of the Lancet Commission. Lancet. 2020;396:413-46. Documents de l'INESSS Institut national d'excellence en santé et en services sociaux. Outils de repérage mesurant les fonctions cognitives, l'autonomie fonctionnelle et les symptômes comportementaux et psychologiques de la démence. 2015. Institut national d'excellence en santé et en services sociaux. Alzheimer – outils / activités. 2015.

Dr. Deanna Saylor talks with Dr. Senjuti Saha about colonialism in global health and the importance of pathogen genomics.  Read the related article in The Lancet.  Disclosures can be found at Neurology.org. 

In this episode of The Food Professor Podcast presented by Caddle, co-hosts Michael LeBlanc and Dr. Sylvain Charlebois bring their trademark mix of food industry news analysis and an in-depth conversation with a leading Canadian food entrepreneur.The episode opens with a wide-ranging look at the Canadian retail and restaurant landscape. Sylvain shares highlights from his keynote in Brampton, Ontario, where the city is building momentum as a potential logistics hub for food and agriculture. Michael and Sylvain discuss strong retail sales numbers, resilience in consumer spending, and a new Restaurants Canada report. The report highlights shifting meal occasions, with Canadians dining out less often but increasingly turning to delivery services like UberEats and DoorDash. They also unpack the surprising rise of solo dining, with nearly 30% growth in single reservations year over year, and how restaurants can adapt to this trend through design and menu innovation. The hosts then tackle Farm Credit Canada's call for greater export diversification, weighing the challenges of competing in heavily subsidized global markets. Finally, they examine the U.S. government's controversial decision to cut data collection on food insecurity, with Sylvain stressing the long-term risks of limiting access to robust research data.The second half of the episode welcomes Kirk Homenick, President of Naturally Homegrown Foods, the Surrey, B.C.–based company behind Hardbite Chips and PopTastic popcorn. Kirk shares the story of his company's growth from humble beginnings in Maple Ridge to its current 42,000-square-foot facility. He explains how Hardbite has stood out in the competitive snack aisle by emphasizing transparency, Canadian-grown ingredients, and lifestyle-driven branding. Kirk highlights the role of avocado oil in fueling 82% annual growth since 2018, how PopTastic quickly became an award-winning hit, and why innovation in seasonal flavours and packaging keeps the brand fresh and relevant.Kirk also offers a candid look at challenges, from volatile ingredient costs to managing manufacturing complexity, and how his team leans on operational excellence and creativity to stay ahead. Looking forward, he outlines plans for geographic expansion into Eastern Canada and the U.S., while teasing the development of entirely new snack brands focused on functionality and evolving consumer demand.With both big-picture analysis and insider insights from one of Canada's most dynamic snack entrepreneurs, this episode delivers food for thought on the future of retail, restaurants, and the growing snack market. The Food Professor #podcast is presented by Caddle. About UsDr. Sylvain Charlebois is a Professor in food distribution and policy in the Faculties of Management and Agriculture at Dalhousie University in Halifax. He is also the Senior Director of the Agri-food Analytics Lab, also located at Dalhousie University. Before joining Dalhousie, he was affiliated with the University of Guelph's Arrell Food Institute, which he co-founded. Known as “The Food Professor”, his current research interest lies in the broad area of food distribution, security and safety. Google Scholar ranks him as one of the world's most cited scholars in food supply chain management, food value chains and traceability.He has authored five books on global food systems, his most recent one published in 2017 by Wiley-Blackwell entitled “Food Safety, Risk Intelligence and Benchmarking”. He has also published over 500 peer-reviewed journal articles in several academic publications. Furthermore, his research has been featured in several newspapers and media groups, including The Lancet, The Economist, the New York Times, the Boston Globe, the Wall Street Journal, Washington Post, BBC, NBC, ABC, Fox News, Foreign Affairs, the Globe & Mail, the National Post and the Toronto Star.Dr. Charlebois sits on a few company boards, and supports many organizations as a special advisor, including some publicly traded companies. Charlebois is also a member of the Scientific Council of the Business Scientific Institute, based in Luxemburg. Dr. Charlebois is a member of the Global Food Traceability Centre's Advisory Board based in Washington DC, and a member of the National Scientific Committee of the Canadian Food Inspection Agency (CFIA) in Ottawa. Michael LeBlanc is the president and founder of M.E. LeBlanc & Company Inc, a senior retail advisor, keynote speaker and now, media entrepreneur. He has been on the front lines of retail industry change for his entire career. Michael has delivered keynotes, hosted fire-side discussions and participated worldwide in thought leadership panels, most recently on the main stage in Toronto at Retail Council of Canada's Retail Marketing conference with leaders from Walmart & Google. He brings 25+ years of brand/retail/marketing & eCommerce leadership experience with Levi's, Black & Decker, Hudson's Bay, CanWest Media, Pandora Jewellery, The Shopping Channel and Retail Council of Canada to his advisory, speaking and media practice.Michael produces and hosts a network of leading retail trade podcasts, including the award-winning No.1 independent retail industry podcast in America, Remarkable Retail with his partner, Dallas-based best-selling author Steve Dennis; Canada's top retail industry podcast The Voice of Retail and Canada's top food industry and one of the top Canadian-produced management independent podcasts in the country, The Food Professor with Dr. Sylvain Charlebois from Dalhousie University in Halifax.Rethink Retail has recognized Michael as one of the top global retail experts for the fourth year in a row, Thinkers 360 has named him on of the Top 50 global thought leaders in retail, RTIH has named him a top 100 global though leader in retail technology and Coresight Research has named Michael a Retail AI Influencer. If you are a BBQ fan, you can tune into Michael's cooking show, Last Request BBQ, on YouTube, Instagram, X and yes, TikTok.Michael is available for keynote presentations helping retailers, brands and retail industry insiders explaining the current state and future of the retail industry in North America and around the world.

Uno studio pubblicato su The Lancet lancia un messaggio chiaro: entro il 2050 i casi di tumore nel mondo potrebbero superare i 30 milioni, con oltre 18 milioni di decessi. Ma c’è un dato che fa la differenza: il 42% dei decessi è legato a fattori di rischio modificabili e dunque la vera sfida è la prevenzione. Ne parliamo con il prof. Antonio Moschetta, ordinario di Medicina interna dell'Ateneo di Bari e direttore dell’Unità operativa complessa di medicina interna presso la Clinica Medica Frugoni del Policlinico di Bari.

In this journal club, we will discuss two pivotal studies in ILD, the FIBRONEER study and the RECITAL study: Nerandomilast in Patients with Progressive Pulmonary Fibrosis, Maher, T.M. et al. NEJM. 2025 May 19. doi: 10.1056 Rituximab versus intravenous cyclophosphamide in patients with connective tissue disease-associated interstitial lung disease in the UK (RECITAL): a double-blind, double-dummy, randomised, controlled, phase 2b trial, Maher T.M., et al. Lancet 2023 Jan;11(1). doi: 10.1016 Panelists: Toby Maher, MD Shervin Assassi, MD Jack Cush, Moderator

L'arrivée de la nouvelle administration Trump début 2025 a sonné la fin de l'USAID, l'agence du gouvernement des États-Unis chargée du développement économique et de l'aide humanitaire dans le monde. Selon une étude publiée par The Lancet le 1ᵉʳ juillet, l'effondrement des financements américains qui étaient dédiés à l'aide internationale pourrait entraîner la mort de plus de 14 millions de personnes. Quelles répercussions concrètes cela a sur le terrain pour les acteurs de santé ? Nous posons la question à des activistes de santé en Afrique.   Dr Bintou Kéita Dembele, médecin directrice d'ARCAD/SIDA au Mali (ARCAD-SIDA est la première association de lutte contre le Sida au Mali) Denise Ngatchou, directrice exécutive de Horizons Femmes au Cameroun  Dr Ephrem Mensah, médecin généraliste, directeur exécutif de l'ONG Espoir Vie-Togo (EVT) dont le siège est à Lomé.    Programmation musicale :  ► Boy Spyce, Jeriq – Achalugo  ► Sahad – Vultures.

L'arrivée de la nouvelle administration Trump début 2025 a sonné la fin de l'USAID, l'agence du gouvernement des États-Unis chargée du développement économique et de l'aide humanitaire dans le monde. Selon une étude publiée par The Lancet le 1ᵉʳ juillet, l'effondrement des financements américains qui étaient dédiés à l'aide internationale pourrait entraîner la mort de plus de 14 millions de personnes. Quelles répercussions concrètes cela a sur le terrain pour les acteurs de santé ? Nous posons la question à des activistes de santé en Afrique.   Dr Bintou Kéita Dembele, médecin directrice d'ARCAD/SIDA au Mali (ARCAD-SIDA est la première association de lutte contre le Sida au Mali) Denise Ngatchou, directrice exécutive de Horizons Femmes au Cameroun  Dr Ephrem Mensah, médecin généraliste, directeur exécutif de l'ONG Espoir Vie-Togo (EVT) dont le siège est à Lomé.    Programmation musicale :  ► Boy Spyce, Jeriq – Achalugo  ► Sahad – Vultures.

Maternal perception of decreased fetal movement at term occurs in up to 15% of pregnancies and is a cause for maternal and provider concern. All maternal concerns of decreased fetal movement require an assessment of fetal wellbeing. But what about the patient with recurrent episodes of reduced fetal movements at term? Routine induction of labor is not supported solely for decreased fetal movement in a non-growth-restricted fetus, as increased intervention rates (including induction of labor and early term birth) have not demonstrated improved perinatal outcomes and may increase neonatal morbidity, such as respiratory distress and NICU admission. Some international sources (ISUOG) have recognized the cerebroplacental ratio (CPR) as a possible ultrasound tool to investigate possible early placental insufficiency before fetal growth restriction occurs. Is CPR helpful for decreased fetal movements at term? A new publication from the Lancet's new journal- Obstetrcis, Gynecology, and Women's Health- states that it is. Is the CPR ultrasound assessment recognized by the ACOG or SMFM? Listen in for details. 1. The cerebroplacental ratio: a useful marker but should it be a screening test? (2025): https://obgyn.onlinelibrary.wiley.com/doi/10.1002/uog.29154#:~:text=The%20ISUOG%20guidelines%20recommend%20using,after%2038%20weeks'%20gestation44.2. Turner JM, Flenady V, Ellwood D, Coory M, Kumar S.Evaluation of Pregnancy Outcomes Among Women With Decreased Fetal Movements.JAMA logoJAMA Network Open. 2021;4(4):e215071. doi:10.1001/jamanetworkopen.2021.5071.3. Cerebroplacental ratio-based management versus care as usual in non-small-for-gestational-age fetuses at term with maternal perceived reduced fetal movements (CEPRA): a multicentre, cluster-randomised controlled trial. https://www.sciencedirect.com/science/article/pii/S30505038250000204. Hofmeyr GJ, Novikova N. Management of Reported Decreased Fetal Movements for Improving Pregnancy Outcomes. The Cochrane Database of Systematic Reviews. 2012;(4):CD009148. doi:10.1002/14651858.CD009148.pub2.STRONG COFFEE PROMO: 20% Off Strong Coffee Company https://strongcoffeecompany.com/discount/CHAPANOSPINOBG

00:02:10 – Jimmy Kimmel Pulled Off AirKimmel is suspended after mocking Trump, with the FCC accused of pressuring networks into compliance. 00:07:43 – Bureaucracy as Speech PoliceUnelected regulators weaponize licenses and rules to censor content, compared to mafia-style intimidation. 00:24:52 – Both Parties Embrace CensorshipAnalysis that Republicans and Democrats alike are now justifying cancel culture, betraying Kirk's free speech legacy. 00:49:57 – Israel Lobby & Boycott BansConcerns about pro-Israel groups pushing GOP leaders to outlaw boycotts, further undermining free speech. 00:55:09 – Bondi vs. Kirk on Hate SpeechPam Bondi calls to outlaw hate speech, directly contradicting Kirk's past defense of free expression. 01:15:23 – Golden Trump Statue & Cult ImageryDiscussion of Trump's cult-like following, including a golden statue erected in DC, and how his lawsuits read like propaganda hagiographies. 01:18:08 – Weaponizing Lawsuits & CensorshipConcerns that Trump's lawfare isn't about winning in court but punishing media through process, intimidation, and regulatory pressure. 01:47:00 – Dearborn Mayor Tells Christian to LeaveMayor of Dearborn, Michigan tells a resident critical of Hezbollah/Hamas sympathizers that he is “not welcome” in the city, highlighting cultural tensions. 01:50:24 – Gaza, Netanyahu & Just WarDebate over Israel's war in Gaza, Trump's anger at Netanyahu for targeting Hamas leaders in Doha, and the moral principles of just war. 02:06:26 – Celente on Hate Speech & Endless WarsGerald Celente blasts the hypocrisy of labeling dissent as “hate speech” while U.S. presidents wage murderous wars, citing Obama, Clinton, and Bush. 02:10:15 – Trump's Broken Peace PromisesTrump is accused of lying about ending wars while escalating Venezuela strikes. Comparisons are drawn to Duterte's extrajudicial killings in the Philippines. 02:15:53 – Israel, Genocide & Kushner's DealsDiscussion of U.S. support for Israeli bombardment of Gaza, Kushner's billion-dollar Gulf investments, and how financial interests override peace. 02:33:56 – Venezuela, Oil & U.S. MeddlingAnalysis of U.S. attempts to overthrow Maduro, framed as another “war for oil” racket. Corporate and political elites are accused of profiting from intervention. 02:36:21 – We the People's Party VisionCelente announces domain registrations for “We the People's Party,” arguing populism is the future and rallies like “Unite the Kingdom” show the growing pushback. 02:47:21 – FCC Shakedowns & Open CorruptionTrump's use of FCC pressure to extract millions from CBS and Paramount is described as mafia-style extortion. 03:54:37 – Gaza Death Toll & Zionism CritiqueConversation returns to Gaza with Lancet estimates of 200,000 deaths, while U.S. leaders openly align with Israeli policy. Zionism is critiqued as a political ideology, not faith. 02:57:29 – Peace Rally & Isolationist LabelCelente promotes his upcoming Occupy Peace rally, arguing that rejecting endless wars isn't isolationism but moral necessity. Follow the show on Kick and watch live every weekday 9:00am EST – 12:00pm EST https://kick.com/davidknightshow Money should have intrinsic value AND transactional privacy: Go to https://davidknight.gold/ for great deals on physical gold/silverFor 10% off Gerald Celente's prescient Trends Journal, go to https://trendsjournal.com/ and enter the code KNIGHTFind out more about the show and where you can watch it at TheDavidKnightShow.com If you would like to support the show and our family please consider subscribing monthly here: SubscribeStar https://www.subscribestar.com/the-david-knight-showOr you can send a donation throughMail: David Knight POB 994 Kodak, TN 37764Zelle: @DavidKnightShow@protonmail.comCash App at: $davidknightshowBTC to: bc1qkuec29hkuye4xse9unh7nptvu3y9qmv24vanh7Become a supporter of this podcast: https://www.spreaker.com/podcast/the-david-knight-show--2653468/support.

Ep. 696: Mr. Harrison's Confessions | Chapters 3-4 Book talk begins at 25:15 Pears, parties, and peculiar housemates—Mr. Harrison's adventures just keep getting more awkward (and more entertaining). --------------------------------------------------------------- SEPTEMBER Raffle - THIS WEEK'S TEA:   and  (thank you LilyM) We caught Hank  The Ultimate  video from @KristineVike And the evil of  (actually, she has a LOT of useful informational videos!) Spectacular FIXED SciShow video: I Remade the SciShow Knitting Video (with accurate SCIENCE)  Solomon's Seal: Dutch Tiles—as with Cranford, these were out of style when the story was written/takes place. They have a resurgence of popularity during the Arts & Crafts movement:  The Jargonelle pear () is an ancient, hardy, long-lived pear variety, first mentioned in the 17th century. It produces medium-sized, yellow-green fruit with a reddish flush and musky, sweet, juicy flesh, ripe in late summer. The fruit must be eaten fresh as it does not store well. &  again Duncombe (silent final “be”) The back room was my consulting-room (“the library,” he advised me to call it), and he gave me a skull to put on the top of my bookcase, in which the medical books were all ranged on the conspicuous shelves; while Miss Austen, Dickens and Thackeray were, by Mr. Morgan himself, skilfully placed in a careless way, upside down or with their backs turned to the wall. HA! Women's veils:  deep widow's mourning; such veils and fails, and capes and cloaks, that she looked like a black crape haycock. very mal-àpropos that I could hardly keep from smiling; but I would not have done it for the world, … ‘“I have the ‘dognoses' of my dear husband's complaint in my desk, Mr. Harrison, if you would like to draw up the case for the Lancet. :  is a comedic character from Richard Brinsley Sheridan's 1775 play The Rivals. She is a pretentious and self-important aunt who constantly makes humorous verbal blunders by using words that sound similar to, but are inappropriate for, the intended word. This type of linguistic error is now known as a . Her name is derived from the French term “mal à propos,” which means “inappropriate” or “poorly placed”. ***a memorable scene occurs when she instructs her niece, Lydia Languish, on the importance of controlling her passions, famously advising her to begin matrimony with “a little aversion,” and later attempts to describe Lydia's headstrong nature by calling her “as headstrong as an allegory on the banks of the Nile”. then She tells Lydia that she must forget the young man, saying, “But I say it is, miss; there is nothing on earth so easy as to forget, if a person chooses to set about it. I'm sure I have as much forgot your poor dear uncle as if he had never existed”. Miscellaneous BOOK/WATCH PARTIES coming up in 2025: Last Thursday of every month, 8pm Eastern: Sep—The Last Unicorn (movie) Oct—Random Harvest (book) Nov—Random Harvest (movie) Dec—Lamb: The Gospel According to Biff, Christ's Childhood Pal (book) *CraftLit's Socials* • Find everything here: https://www.linktr.ee/craftlitchannel • Join the newsletter: http://eepurl.com/2raf9  • Podcast site: http://craftlit.com • Facebook: https://www.facebook.com/CraftLit/ • Facebook group: https://www.facebook.com/groups/craftlit • Pinterest: https://www.pinterest.com/craftlit/ • TikTok podcast: https://www.tiktok.com/@craftlit • Email: heather@craftlit.com • Previous CraftLit Classics can be found here: https://bit.ly/craftlit-library-2023   *SUPPORT THE SHOW!* • CraftLit App Premium feed bit.ly/libsynpremiumcraftlit (only one tier available) • PATREON:   https://patreon.com/craftlit (all tiers, below) ——Walter Harright -  $5/mo for the same audio as on App ——Jane Eyre - $10/mo for even-month Book Parties ——Mina Harker - $15/mo for odd-month Watch Parties *All tiers and benefits are also available as* —*YouTube Channel Memberships*  —*Ko-Fi* https://ko-fi.com/craftlit  —*NEW* at CraftLit.com — Premium Memberships https://craftlit.com/membership-levels/ *IF you want to join a particular Book or Watch Patry but you don't want to join any of the above membership options*, please use PayPal.me/craftlit or CraftLit @ Venmo and include what you want to attend in the message field. Please give us at least 24 hours to get your message and add you to the attendee list.     • Download the FREE CraftLit App for iOS or Android (you can call or email feedback straight from within the app) • Call 1-206-350-1642

00:02:10 – Jimmy Kimmel Pulled Off AirKimmel is suspended after mocking Trump, with the FCC accused of pressuring networks into compliance. 00:07:43 – Bureaucracy as Speech PoliceUnelected regulators weaponize licenses and rules to censor content, compared to mafia-style intimidation. 00:24:52 – Both Parties Embrace CensorshipAnalysis that Republicans and Democrats alike are now justifying cancel culture, betraying Kirk's free speech legacy. 00:49:57 – Israel Lobby & Boycott BansConcerns about pro-Israel groups pushing GOP leaders to outlaw boycotts, further undermining free speech. 00:55:09 – Bondi vs. Kirk on Hate SpeechPam Bondi calls to outlaw hate speech, directly contradicting Kirk's past defense of free expression. 01:15:23 – Golden Trump Statue & Cult ImageryDiscussion of Trump's cult-like following, including a golden statue erected in DC, and how his lawsuits read like propaganda hagiographies. 01:18:08 – Weaponizing Lawsuits & CensorshipConcerns that Trump's lawfare isn't about winning in court but punishing media through process, intimidation, and regulatory pressure. 01:47:00 – Dearborn Mayor Tells Christian to LeaveMayor of Dearborn, Michigan tells a resident critical of Hezbollah/Hamas sympathizers that he is “not welcome” in the city, highlighting cultural tensions. 01:50:24 – Gaza, Netanyahu & Just WarDebate over Israel's war in Gaza, Trump's anger at Netanyahu for targeting Hamas leaders in Doha, and the moral principles of just war. 02:06:26 – Celente on Hate Speech & Endless WarsGerald Celente blasts the hypocrisy of labeling dissent as “hate speech” while U.S. presidents wage murderous wars, citing Obama, Clinton, and Bush. 02:10:15 – Trump's Broken Peace PromisesTrump is accused of lying about ending wars while escalating Venezuela strikes. Comparisons are drawn to Duterte's extrajudicial killings in the Philippines. 02:15:53 – Israel, Genocide & Kushner's DealsDiscussion of U.S. support for Israeli bombardment of Gaza, Kushner's billion-dollar Gulf investments, and how financial interests override peace. 02:33:56 – Venezuela, Oil & U.S. MeddlingAnalysis of U.S. attempts to overthrow Maduro, framed as another “war for oil” racket. Corporate and political elites are accused of profiting from intervention. 02:36:21 – We the People's Party VisionCelente announces domain registrations for “We the People's Party,” arguing populism is the future and rallies like “Unite the Kingdom” show the growing pushback. 02:47:21 – FCC Shakedowns & Open CorruptionTrump's use of FCC pressure to extract millions from CBS and Paramount is described as mafia-style extortion. 03:54:37 – Gaza Death Toll & Zionism CritiqueConversation returns to Gaza with Lancet estimates of 200,000 deaths, while U.S. leaders openly align with Israeli policy. Zionism is critiqued as a political ideology, not faith. 02:57:29 – Peace Rally & Isolationist LabelCelente promotes his upcoming Occupy Peace rally, arguing that rejecting endless wars isn't isolationism but moral necessity. Follow the show on Kick and watch live every weekday 9:00am EST – 12:00pm EST https://kick.com/davidknightshow Money should have intrinsic value AND transactional privacy: Go to https://davidknight.gold/ for great deals on physical gold/silverFor 10% off Gerald Celente's prescient Trends Journal, go to https://trendsjournal.com/ and enter the code KNIGHTFind out more about the show and where you can watch it at TheDavidKnightShow.com If you would like to support the show and our family please consider subscribing monthly here: SubscribeStar https://www.subscribestar.com/the-david-knight-showOr you can send a donation throughMail: David Knight POB 994 Kodak, TN 37764Zelle: @DavidKnightShow@protonmail.comCash App at: $davidknightshowBTC to: bc1qkuec29hkuye4xse9unh7nptvu3y9qmv24vanh7Become a supporter of this podcast: https://www.spreaker.com/podcast/the-real-david-knight-show--5282736/support.

Stress isn't just something to “manage” — it's a signal, a teacher, and often, an invitation to look deeper at our health, our choices, and our lives. In this solo episode, Darin reframes stress not as an enemy, but as a dashboard light pointing toward misalignments in our nervous system, environment, relationships, and purpose. Drawing on science, practical tools, and personal insight, Darin reveals how layered stress silently drains our vitality — and how to transform it into an ally for growth, healing, and deeper contentment. Whether it's hidden trauma, toxic environments, unresolved conflict, or the modern distractions constantly pulling at our attention, Darin lays out a roadmap to stop the leaks and reclaim the energy already within you. This episode is a powerful reminder: stress isn't the end of the story — it's the beginning of awareness, safety, and a super life.     What You'll Learn in This Episode [00:00] Introduction to the Super Life podcast [03:27] Why stress might not be your enemy [04:17] Stress as an ally: the signals it gives us about misalignment [04:32] The dashboard light metaphor: how stress reveals hidden issues [05:28] The illusion of “no choice” and the infinite possibilities always available [06:12] Global stress statistics and why most people underestimate their stress load [07:23] Hidden stress revealed through heart rate variability and physiology [08:23] Layered stress: how sleep, exercise, and poor choices compound each other [09:25] Safety vs. calm — why your nervous system craves safety first [10:15] Trauma and the unconscious mind: how old wounds drive our stress response [11:54] Inner narratives and negative self-talk as hidden stress multipliers [12:22] The role of community and your social field in stress and resilience [13:53] Relationships, honesty, and how your circle shapes your energy [14:55] Why boundaries around media and politics are vital for mental clarity [17:42] Finding micro-purpose when life feels overwhelming [18:52] Environmental layers of stress — light, air, and clutter [19:15] The existential layer: stress from living without service or purpose [20:12] Stress as a risk amplifier — how it undermines healing and health [20:55] The deeper truth of safety, connection, and higher power [23:00] Practical tools: breathing, grounding, nature, and conscious choices [24:01] Trauma reframed: not a problem, but a protector at the time [25:25] Lessons from Peter Levine and wild animals: releasing trauma physically [26:04] Questions to ask trauma: “What are you protecting me from?” [26:56] Stress as a multiplier of aging, disease, and poor outcomes [29:20] Why stress isn't a single cause — it's layered and chronic [30:18] Anti-stress strategies: circadian rhythm, nature, and gratitude [31:49] Energy leaks to avoid: clutter, poor food, scrolling, bad boundaries [32:22] What matters most: service, contribution, and alignment [33:28] Final toolkit: breathwork, movement, nature, sleep, and gratitude [34:38] The deeper invitation: step into sovereignty and live your SuperLife     Thank You to Our Sponsors: Manna Vitality: Go to mannavitality.com/  or use code DARIN20 for 20% off your order. Bite Toothpaste: Go to trybite.com/DARIN20 or use code DARIN20 for 20% off your first order.     Find More from Darin Olien: Instagram: @darinolien Podcast: SuperLife Podcast Website: superlife.com Book: Fatal Conveniences Check out my podcast with Dr. Amy Abbington     Key Takeaway “Stress is not the enemy. It's a dashboard light — a teacher showing you where you're out of alignment. When you reframe stress, you reclaim your energy and create space for healing, safety, and the joy of living a super life.”     Bibliography (selected, peer-reviewed) Sources: Gallup Global Emotions (2024); Gallup U.S. polling (2024); APA Stress in America (2023); Natarajan et al., Lancet Digital Health (2020); Orini et al., UK Biobank (2023); Martinez et al. (2022); Leiden University (2025). Cohen S, Tyrrell DA, Smith AP. Psychological stress and susceptibility to the common cold. N Engl J Med.1991;325(9):606–612. New England Journal of Medicine Cohen S, et al. Chronic stress, glucocorticoid receptor resistance, inflammation, and disease risk. Proc Natl Acad Sci USA. 2012;109(16):5995–5999. PNAS Kiecolt-Glaser JK, et al. Slowing of wound healing by psychological stress. Lancet. 1995;346(8984):1194–1196. The Lancet Kiecolt-Glaser JK, et al. Hostile marital interactions, proinflammatory cytokine production, and wound healing.Arch Gen Psychiatry. 2005;62(12):1377–1384. JAMA Network Tawakol A, et al. Relation between resting amygdalar activity and cardiovascular events. Lancet.2017;389(10071):834–845. The Lancet Epel ES, et al. Accelerated telomere shortening in response to life stress. Proc Natl Acad Sci USA.2004;101(49):17312–17315. PNAS McEwen BS, Stellar E. Stress and the individual: mechanisms leading to disease. Arch Intern Med.1993;153(18):2093–2101. PubMed McEwen BS, Wingfield JC. Allostasis and allostatic load. Ann N Y Acad Sci. 1998;840:33–44. PubMed Felitti VJ, et al. Relationship of childhood abuse and household dysfunction to many leading causes of death in adults (ACE Study). Am J Prev Med. 1998;14(4):245–258. AJP Mon Online Edmondson D, et al. PTSD and cardiovascular disease. Ann Behav Med. 2017;51(3):316–327. PMC Afari N, et al. Psychological trauma and functional somatic syndromes: a systematic review and meta-analysis.Psychosom Med. 2014;76(1):2–11. PMC Goyal M, et al. Meditation programs for psychological stress and well-being: a systematic review and meta-analysis. JAMA Intern Med. 2014;174(3):357–368. PMC Qiu Q, et al. Forest therapy: effects on blood pressure and salivary cortisol—a meta-analysis. Int J Environ Res Public Health. 2022;20(1):458. PMC Laukkanen T, et al. Sauna bathing and reduced fatal CVD and all-cause mortality. JAMA Intern Med.2015;175(4):542–548. JAMA Network Zureigat H, et al. Physical activity lowers CVD risk by reducing stress-related neural activity. J Am Coll Cardiol.2024;83(16):1532–1546. PMC Holt-Lunstad J, Smith TB, Layton JB. Social relationships and mortality risk: a meta-analytic review. PLoS Med.2010;7(7):e1000316. PMC Chen Y-R, Hung K-W. EMDR for PTSD: meta-analysis of RCTs. PLoS One. 2014;9(8):e103676. PLOS Hoppen TH, et al. Network/pairwise meta-analysis of PTSD psychotherapies—TF-CBT highest efficacy overall.Psychol Med. 2023;53(14):6360–6374. PubMed van der Kolk BA, et al. Yoga as an adjunctive treatment for PTSD: RCT. J Clin Psychiatry. 2014;75(6):e559–e565. PubMed Kelly U, et al. Trauma-center trauma-sensitive yoga vs CPT in women veterans: RCT. JAMA Netw Open.2023;6(11):e2342214. JAMA Network Bentley TGK, et al. Breathing practices for stress and anxiety reduction: components that matter. Behav Sci (Basel). 2023;13(9):756. 

In this episode, we give a wrap-up of late-breaking clinical science presented at the ESC Congress 2025 in Madrid. First, David Berg presents the DAPA ACT HF-TIMI 68 trial, reporting on dapagliflozin in patients hospitalized for acute heart failure, along with a meta-analysis of SGLT2 inhibitors in this setting. Next, Javed Butler highlights results of the VICTOR trial, a large phase 3 study of vericiguat in chronic heart failure with reduced ejection fraction. Then, Andre Zimerman discusses the PhysioSync-HF trial, comparing conduction system pacing with biventricular resynchronization therapy in patients with HFrEF. Finally, Kieran Docherty shares insights from a community-based study on the benefits of early initiation of disease-modifying therapy in suspected heart failure.   Additional information: Topic 1: With Gregorio Tersalvi, Mayo Clinic, Rochester, MN - USA, David Berg, Brigham and Women's Hospital, Boston - USA and Novi Yanti Sari, Siloam Hospitals Group, Jakarta - Indonesia Results paper: Dapagliflozin in Patients Hospitalized for Heart Failure: Primary Results of the DAPA ACT HF-TIMI 68 Randomized Clinical Trial and Meta-Analysis of Sodium-Glucose Cotransporter-2 Inhibitors in Patients Hospitalized for Heart Failure Replay ESC Congress Hot Line: https://esc365.escardio.org/presentation/312142 Circulation. 2025 Aug 29. doi: 10.1161/CIRCULATIONAHA.125.076575.    Topic 2: With Javed Butler, Baylor Scott & White Health, Dallas - USA and Henrike Arfsten, Medical University of Vienna, Vienna - Austria Results papers: Vericiguat in patients with chronic heart failure and reduced ejection fraction (VICTOR): a double-blind, placebo-controlled, randomised, phase 3 trial Lancet. 2025 Replay ESC Congress hotline: https://esc365.escardio.org/presentation/312148 doi: 10.1016/S0140-6736(25)01665-4.  Vericiguat for patients with heart failure and reduced ejection fraction across the risk spectrum: an individual participant data analysis of the VICTORIA and VICTOR trials Lancet. 2025 Aug 29:S0140-6736(25)01682-4. doi: 10.1016/S0140-6736(25)01682-4.   Topic 3: With Andre Zimerman, Hospital Moinhos De Vento, Porto Alegre - Brazil and Floran Sahiti, University Hospital of Wurzburg, Wurzburg - Germany Methods paper: Conduction system pacing vs biventricular resynchronization in heart failure with reduced ejection fraction and left bundle branch block: Rationale and design of the PhysioSync-HF Trial Am Heart J. 2025 Dec:290:38-45. Replay ESC Congress: https://esc365.escardio.org/session/50327 doi: 10.1016/j.ahj.2025.06.002.   Topic 3: With Kieran Docherty, University of Glasgow, Glasgow - UK and Jolie Bruno, Inserm UMR-S942, Paris - France Results paper: Benefit of early initiation of disease-modifying therapy in community-based patients with suspected heart failure Eur Heart J. 2025 Aug 29:ehaf675. doi: 10.1093/eurheartj/ehaf675.    This 2025 HFA Cardio Talk podcast series is supported by Bayer AG in the form of an unrestricted financial support. The discussion has not been influenced in any way by its sponsor. 

In this episode of The Food Professor Podcast, presented by Caddle, hosts Michael LeBlanc and Dr. Sylvain Charlebois deliver their trademark mix of hard-hitting food industry analysis and an insightful conversation with a top Canadian food leader.The episode kicks off with a wide-ranging news segment. Michael and Sylvain debate Canada's “Big Five” fast-tracked federal projects and why agri-food continues to be sidelined in national infrastructure planning. They highlight the missed opportunities for boosting food supply chain efficiency, from beef processing facilities to critical ports like Vancouver, which remain among the world's least efficient. The hosts also unpack new EV tariffs targeting Chinese electric vehicles, dissect how they intersect with trade relations, and explore why Canada's ag sector is often the first target of Chinese retaliation. The discussion moves to TikTok's ongoing influence in food marketing, recalling Ocean Spray's viral cranberry moment and the elusive quest for the next billion-view food trend. Rounding out the news, they tackle inflation, food counter-tariffs, and how media narratives are obscuring the real cost impact on Canadian consumers—everything from coffee and tea prices soaring by 20% to rising costs in meat, sugar, and spices.The conversation then shifts to a feature interview with James Maitland, CEO of Les Aliments Dainty Foods Inc.—Canada's only rice mill, located in Windsor, Ontario. James shares his career journey from General Mills and Maple Leaf Foods to leading Dainty, a company with a proud 140-year legacy. He reveals breaking news about the company's upcoming U.S. expansion, with a $50–$75 million investment in a new facility focused on retort pouch technology and ready-to-eat innovation. James explains how Dainty sources authentic rice from global origins, mills it in Canada, and continues to grow as a trusted brand on Canadian shelves. The discussion highlights innovation, from the launch of the new Timewise brand—featuring convenient pasta and rice dishes—to sustainability initiatives like regeneratively grown rice and packaging breakthroughs.With unique insights on tariffs, supply chain challenges, and the balance between legacy and growth, James Maitland provides a behind-the-scenes look at what it takes to lead a Canadian food brand into the future. The Food Professor #podcast is presented by Caddle. About UsDr. Sylvain Charlebois is a Professor in food distribution and policy in the Faculties of Management and Agriculture at Dalhousie University in Halifax. He is also the Senior Director of the Agri-food Analytics Lab, also located at Dalhousie University. Before joining Dalhousie, he was affiliated with the University of Guelph's Arrell Food Institute, which he co-founded. Known as “The Food Professor”, his current research interest lies in the broad area of food distribution, security and safety. Google Scholar ranks him as one of the world's most cited scholars in food supply chain management, food value chains and traceability.He has authored five books on global food systems, his most recent one published in 2017 by Wiley-Blackwell entitled “Food Safety, Risk Intelligence and Benchmarking”. He has also published over 500 peer-reviewed journal articles in several academic publications. Furthermore, his research has been featured in several newspapers and media groups, including The Lancet, The Economist, the New York Times, the Boston Globe, the Wall Street Journal, Washington Post, BBC, NBC, ABC, Fox News, Foreign Affairs, the Globe & Mail, the National Post and the Toronto Star.Dr. Charlebois sits on a few company boards, and supports many organizations as a special advisor, including some publicly traded companies. Charlebois is also a member of the Scientific Council of the Business Scientific Institute, based in Luxemburg. Dr. Charlebois is a member of the Global Food Traceability Centre's Advisory Board based in Washington DC, and a member of the National Scientific Committee of the Canadian Food Inspection Agency (CFIA) in Ottawa. Michael LeBlanc is the president and founder of M.E. LeBlanc & Company Inc, a senior retail advisor, keynote speaker and now, media entrepreneur. He has been on the front lines of retail industry change for his entire career. Michael has delivered keynotes, hosted fire-side discussions and participated worldwide in thought leadership panels, most recently on the main stage in Toronto at Retail Council of Canada's Retail Marketing conference with leaders from Walmart & Google. He brings 25+ years of brand/retail/marketing & eCommerce leadership experience with Levi's, Black & Decker, Hudson's Bay, CanWest Media, Pandora Jewellery, The Shopping Channel and Retail Council of Canada to his advisory, speaking and media practice.Michael produces and hosts a network of leading retail trade podcasts, including the award-winning No.1 independent retail industry podcast in America, Remarkable Retail with his partner, Dallas-based best-selling author Steve Dennis; Canada's top retail industry podcast The Voice of Retail and Canada's top food industry and one of the top Canadian-produced management independent podcasts in the country, The Food Professor with Dr. Sylvain Charlebois from Dalhousie University in Halifax.Rethink Retail has recognized Michael as one of the top global retail experts for the fourth year in a row, Thinkers 360 has named him on of the Top 50 global thought leaders in retail, RTIH has named him a top 100 global though leader in retail technology and Coresight Research has named Michael a Retail AI Influencer. If you are a BBQ fan, you can tune into Michael's cooking show, Last Request BBQ, on YouTube, Instagram, X and yes, TikTok.Michael is available for keynote presentations helping retailers, brands and retail industry insiders explaining the current state and future of the retail industry in North America and around the world.

L'émission 28 minutes du 18/09/2025 Antibiorésistance : la prochaine grande crise sanitaire mondiale ? L'antibiorésistance est-elle la prochaine grande pandémie mondiale ? Pascale Cossart, biologiste française, s'en inquiète. Pionnière en microbiologie cellulaire, elle parle dans son dernier livre, “Virus contre bactéries. Une solution pour vaincre l'antibiorésistance” (éditions Odile Jacob), “d'une épidémie invisible et silencieuse”. Avec la découverte de la pénicilline et des antibiotiques, tout le monde croyait que les maladies infectieuses allaient disparaître. Mais, selon une étude publiée dans la revue médicale “The Lancet” l'année dernière, 39 millions de personnes pourraient mourir d'ici 2050 à travers le monde à cause d'un usage abusif et incorrect des antibiotiques. La France est une grande consommatrice d'antibiotiques, se situant au cinquième rang à l'échelle européenne. Pour faire face à cette antibiorésistance, Pascale Cossart défend une pratique datant de 1917 et pourtant jamais homologuée : la phagothérapie. Cette technologie permet de détruire les bactéries en utilisant les virus qui les infectent sans affecter les cellules. L'école, incarnation d'une société à deux vitesses ? Au moins un enseignant sur trois était annoncé en grève dans le primaire aujourd'hui. Enseignants mais aussi chefs d'établissements, médecins scolaires, personnels administratifs se sentent concernés par un “ras-le-bol”, aussi bien dans le primaire que le secondaire. Les griefs sont nombreux : salaires, classes surchargées, manque de moyens, etc. Face à ce sombre  constat, l'école privée a de plus en plus la côte puisque 45 % des Français estiment que leurs enfants bénéficieront d'une meilleure scolarité dans le privé contre 27 % dans le public, selon un sondage de la Fondation Kairos de mai 2025. À ce rythme, un collégien sur deux pourrait être scolarisé dans le privé en 2034, selon une étude menée par Julien Grenet, directeur de recherche au CNRS. Aujourd'hui en France, il existe 7 500 établissements privés sous contrat (à plus de 90 % catholiques). Si ces écoles, financées à 75 % par l'État à hauteur de 10 milliards d'euros, doivent appliquer les programmes de l'Éducation nationale, les horaires, veiller à la liberté de conscience des élèves, ces obligations sont souvent bafouées, selon un rapport d'enquête parlementaire qui dénonce leur manque de transparence et leur contrôle. Enfin, Xavier Mauduit s'intéresse à l'histoire de l'or alors que plusieurs pépites du plus précieux des métaux ont été dérobées au Muséum d'histoire naturelle de Paris cette semaine. Marie Bonnisseau nous parle d'une technologie révolutionnaire : la cassette ADN qui permet de stocker une quantité importante de données numériques, une alternative aux data centers très coûteux en énergie. 28 minutes est le magazine d'actualité d'ARTE, présenté par Élisabeth Quin du lundi au jeudi à 20h05. Renaud Dély est aux commandes de l'émission le vendredi et le samedi. Ce podcast est coproduit par KM et ARTE Radio. Enregistrement 18 septembre 2025 Présentation Élisabeth Quin Production KM, ARTE Radio

A large meta-analysis in The Lancet found clopidogrel superior to aspirin for long-term secondary prevention in coronary artery disease, reducing major cardiovascular events by 14% without added bleeding risk. The REBOOT trial in NEJM showed no benefit of beta-blockers in post-MI patients with preserved ejection fraction, and even potential harm in women on high doses, prompting reevaluation of routine use. Finally, a phase 2 trial in JAMA Internal Medicine showed daily azelastine nasal spray reduced COVID-19 incidence by 67% and shortened illness duration, though larger studies are needed to confirm its prophylactic role.

70 years ago this year, a researcher at University College of the West Indies in Jamaica published a paper in The Lancet describing a case series of patients with diabetes who did not have the typical hallmarks of type 1 or type 2 disease. They were young, underweight, resistant to insulin, and did not tend to have ketoacidosis. The condition was coined J-type diabetes, after Jamaica, and it was briefly recognised by WHO as malnutrition-related diabetes. However, WHO removed it from its official classification in 1999, because of insufficient evidence of its association with malnutrition. In this episode of In Conversation With, Professor Meredith Hawkins and Professor Nihal Thomas explain how this “lost” condition, which they estimate affects 25 million people worldwide, particularly in low- and middle-income countries, is now becoming more widely recognised and better understood, albeit with a long way to go in terms of additional research. They also propose a new name: type 5 diabetes. Listen now to explore the fascinating history of the disorder and the urgent need for effective treatments.Read the full Viewpoint:https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(25)00263-3/fulltext?dgcid=buzzsprout_icw_podcast_September_25_langloContinue this conversation on social!Follow us today at...https://thelancet.bsky.social/https://instagram.com/thelancetgrouphttps://facebook.com/thelancetmedicaljournalhttps://linkedIn.com/company/the-lancethttps://youtube.com/thelancettv

Think you can out-eat or out-exercise poor sleep? You can't. Sleep isn't just rest—it's repair, it's hormone balance, it's fat burning, and it's brain detox. So if you've been working hard on your health but still feeling stuck, your sleep might be the reason your results aren't showing up. In this episode, I break down what sleep really does for your body—from hormone production and muscle repair to fat metabolism and cognitive function. I explain why just one night of poor sleep can throw your insulin, mood, and metabolism off—and what chronic sleep debt is quietly doing to your body over time. We're done treating sleep like a luxury. It's a biological necessity. What you'll learn: What your "night shift workers" are doing while you sleep (and why they're striking) Why deep and REM sleep are non-negotiable for fat loss and brain function How lack of sleep increases cravings, brain fog, and belly fat What poor sleep does to your hormones—including cortisol and testosterone 5 science-backed habits you can start tonight for better sleep Sleep is the foundation of every health goal you have—so let's stop ignoring it.   Ashley's Favorite Sleep Mask   Get Weekly Health Tips:  thrivehealthcoachllc.com Let's Connect:@‌ashleythrivehealthcoach or via email: ashley@thrivehealthcoachingllc.com Podcast Produced by Virtually You!   Sources:   Andrews, R. C., Cooper, A. J., Montgomery, A. A., Norcross, A. J., Peters, T. J., Sharp, D. J., ... & Dayan, C. M. (2020). Diet or diet plus physical activity versus usual care in patients with newly diagnosed type 2 diabetes: the Early ACTID randomised controlled trial. The Lancet, 373(9678), 829–835. https://doi.org/10.1016/S0140-6736(09)60484-2

Die Themen in den Wissensnachrichten: +++ Deutschland schneidet schlecht ab im Kampf gegen Krebs, Herzkrankheiten, Schlaganfall & Co +++ TÜV-Studie: Digitalisierung führt zu mehr Elektroschrott +++ Pusteblumen brauchen den richtigen Flow +++**********Weiterführende Quellen zu dieser Folge:Benchmarking progress in non-communicable diseases: a global analysis of cause-specific mortality from 2001 to 2019/ The Lancet, 10.09.2025Wie nachhaltig ist die Digitalisierung? Produkte nachhaltiger gestalten - Anforderungen einhalten/ TÜV-Verband, 11.09.2024Systematic attribution of heatwaves to the emissions of carbon majors/ Nature, 10.09.2025Drug-resistant fungus Candidozyma auris confirmed to spread rapidly in European hospitals: ECDC calls for urgent action/ ECDC, 11.09.2025Redox-driven mineral and organic associations in Jezero Crater, Mars/ Nature, 10.09.2025Alle Quellen findet ihr hier.**********Ihr könnt uns auch auf diesen Kanälen folgen: TikTok und Instagram .

In this episode of the RWS Clinician's Corner, Margaret Floyd Barry takes us behind the scenes into the dynamic world of research and curriculum development in the functional health space. Margaret sits down with two of Restorative Wellness Solutions' powerhouse instructors, Ellen Lovelace and Paige Reagan, for a candid conversation about the challenges, surprises, and daily realities of translating emerging science into practical, safe, and effective tools for clinicians.   In this interview, we discuss:     -Specific ways that Ellen & Paige demonstrate curriculum leadership and research support for RWS   -How to respond to new studies or challenges to existing curriculum    -How to decide which sources to trust   -How to evaluate clinical research (red & green flags)   -Addressing research limitations and gaps    -Using research tools and AI in gathering evidence   The Clinician's Corner is brought to you by Restorative Wellness Solutions.  Follow us: https://www.instagram.com/restorativewellnesssolutions/    Connect with Ellen:  Website: www.abalancedtable.net Facebook: www.facebook.com/abalancedtable Instagram: www.instagram.com/abalancedtable   Connect with Paige: Website: www.naturallynourishedwellness.com Instagram: www.instagram.com/paigereaganntp   Timestamps: 00:00 From Russian Studies to Health Advocacy 07:56 Curriculum Accuracy and Depth Focus 12:57 Using AI for Study Validation 19:20 Evaluating Research Article Credibility 25:24 Animal Study Relevance and Limitations 28:03 "Pediatric Research Gaps in Drug Trials" 33:55 "Teaching Deepens Understanding" 41:17 Questioning AI for Balanced Answers 44:47 Effective Research Strategies and AI Limitations 52:04 Verify Before Believing Headlines 55:52 "Unpaywall: Access Free Academic Papers" 01:00:33 "The Clinician's Corner Podcast" Speaker bios: Ellen Lovelace, Lead Instructor & Curriculum Development Master RHP, MPH, FNTP, Board Certified in Holistic Nutrition® Ellen (she/her) has been actively working to educate and improve the public's health for almost 20 years. Ellen received her Masters in Public Health from The George Washington University, and went on to run everything from tuberculosis prevention programs in Russia to dental health education programs along the Texas/Mexico border. She was also the founding Executive Director of the women's health program at Stanford University. When Ellen became drawn to a more holistic model, she received her certifications as a Nutritional Therapy Consultant and a Master Restorative Health Practitioner. She is the owner of A Balanced Table Nutritional Therapy in San Jose, CA, her private functional nutrition practice. Ellen focuses on cutting through the confusion and nutrition “noise,” digging to the roots of clients' dysfunction, and figuring out the best way for them to eat, drink, and thrive. She uses the IRH functional analysis tools daily, and is excited to share her passion for these methods. Ellen believes that only by focusing on root causes, combined with whole foods nutrition, can true wellness be achieved. Ellen is also a passionate animal lover who volunteers at a wildlife rescue facility, and can often be found smelling of skunk while covered in Mastiff drool.    Paige Reagan, Instructor and Research Master RHP, FNTP Paige has spent most of her career working in Research and Development in the areas of clinical research, regulatory affairs, and medical writing. She has a wide range of experience in the therapeutic areas of cardiovascular health, pulmonary arterial hypertension, diabetes, bone health, osteoarthritis/rheumatoid arthritis, and urology, among others. Her work has contributed to numerous regulatory approvals as well as publications in major medical journals such as the New England Journal of Medicine, Lancet, Circulation, and American Heart Journal. Paige has since earned certifications as a Functional Nutritional Therapy Practitioner and Master Restorative Health Practitioner. She is owner of Naturally Nourished Wellness, a small practice specializing in gut health and the downstream effects of poor digestion. She strives to find balance between the holistic and mainstream approaches and aims to provide her clients with the best of both worlds, using her critical thinking skills from years in research combined with objective laboratory testing and her passion for the restorative power of whole foods and simple lifestyles. She spends her free time exploring the outdoors with her family, swinging kettlebells, and creating baked goods with healthier ingredients.   Keywords: functional nutrition, public health, research process, curriculum development, clinical research, regulatory affairs, medical writing, gastrointestinal healing, lab testing, food sensitivities, evidence-based practice, study design, randomized controlled trials, observational studies, animal studies, peer review, PubMed, Google Scholar, AI tools in research, ChatGPT, consensus, study citations, clinical anecdote, sample size, funding bias, meta-analysis, systematic reviews, biostatistics, clinical protocols, dietary supplements   Disclaimer: The views expressed in the RWS Clinician's Corner series are those of the individual speakers and interviewees, and do not necessarily reflect the views of Restorative Wellness Solutions, LLC. Restorative Wellness Solutions, LLC does not specifically endorse or approve of any of the information or opinions expressed in the RWS Clinician's Corner series. The information and opinions expressed in the RWS Clinician's Corner series are for educational purposes only and should not be construed as medical advice. If you have any medical concerns, please consult with a qualified healthcare professional. Restorative Wellness Solutions, LLC is not liable for any damages or injuries that may result from the use of the information or opinions expressed in the RWS Clinician's Corner series. By viewing or listening to this information, you agree to hold Restorative Wellness Solutions, LLC harmless from any and all claims, demands, and causes of action arising out of or in connection with your participation. Thank you for your understanding.  

Send us a textLast month, The Lancet posted online an article from Stine Johansen, Fredrik Åberg, Emmanuel Tsochatzis and Aleksander Krag, titled "Screening for Advanced Liver Disease." The article aims to update the Wilson and Jungner criteria, initially developed in 1960, to address modern needs and issues. In this conversation, Professor Krag and Dr. Johansen join Roger Green to discuss their article. There are many nuances and high points to cover in this thoughtful, fairly lengthy conversation, but one key point is that screening a mass population for HCC or cirrhosis has an entirely different set of issues and criteria compared to the screening usually discussed on this podcast, which involves identifying a population at increased risk for MASLD or MASH and screening them. Also, healthcare is far more expensive than it was in 1960 with a plethora of high-cost ways to diagnose, treat and manage patients.As a result, the authors started with the 10 Wilson and Jungner criteria and added eight more. During this conversation, Stine emphasizes the need for a comprehensive clinical trial on this issue, and all panelists agree that LiverAIM is likely to serve as the study.

Inflammation is the body's natural way of healing, but when it becomes chronic and hidden, it quietly drives many of today's most common health problems—heart disease, diabetes, dementia, cancer, autoimmune conditions, and more. Unlike the redness and swelling from a cut or sprain, this “silent inflammation” often goes unnoticed while slowly damaging tissues and speeding up aging. Modern life fuels the fire: processed foods, food additives, pollution, plastics, chronic stress, too much sitting, and poor sleep. The good news is inflammation can be calmed by simple daily choices—eating colorful whole foods like berries, leafy greens, beans, nuts, seeds, and omega-3 rich fish; adding herbs and spices like turmeric and cumin; moving regularly; practicing relaxation; and repairing gut health. Even small shifts, like climbing stairs, eating within a shorter window, or reducing sugar, can make a big difference. By lowering inflammation, the body finds balance again, opening the door to more energy, resilience, and healthy aging. In this episode, I discuss, along with Dr. Shilpa Ravella and Dr. David Furman, why it's important to be aware of systemic inflammation and how to address it. Dr. Ravella is a gastroenterologist and Assistant Professor of Medicine at Columbia University Medical Center. She is the author of A Silent Fire: The Story of Inflammation, Diet & Disease, which investigates inflammation—the hidden force at the heart of modern disease. Her writing has appeared in The Atlantic, New York Magazine, The Wall Street Journal, TIME, Slate, Discover, and USA Today, among other publications.  Dr. David Furman is Associate Professor and Director of the Bioinformatics Core at the Buck Institute for Research on Aging, as well as the Director of the Stanford 1000 Immunomes Project. He obtained his doctoral degree in immunology from the School of Medicine, University of Buenos Aires, Argentina, for his work on cancer immune-surveillance. During his postdoctoral training at the Stanford School of Medicine, Dr. Furman focused on the application of advanced analytics to study the aging of the immune system in humans. He has published nearly thirty scientific articles in top-tier journals such as Cell, Nature Medicine, PNAS, The Lancet, and others.  This episode is brought to you by BIOptimizers. Head to bioptimizers.com/hyman and use code HYMAN to save 15%. Full-length episodes can be found here:What Causes Inflammation And How Can You Treat It? The Silent Killer: Inflammation And Chronic Disease How Silent Inflammation Accelerates Aging

Send us a text00:00:00 - Surf's Up: Season 6 Episode 13 Louise Campbell, Jörn Schattenberg and Roger Green continue their discussion of some major issues from earlier this year, while co-authors Aleksander Krag and Stine Johanset join Roger to discuss their recent publication in The Lancet, titled "Screening for Advanced Liver Disease." 00:04:45 - Major Issues of the First Six Months: Integrated Patient ManagementLouise drives this conversation based on two related issues she sees emerging: (i) increasing opportunities for motivated patients to manage their own health and (ii) managing the total patient in an environment where people may be taking incretin agonists as if they are consumer drugs. With increased access to scanning, providers can monitor patients (and patients can self-monitor) more closely. However, some of the issues a provider might find are tricky: patients who undertake what Louise describes as "the sneaky areas patients think are normal, but are probably contributing to disease" due to miseducation or no education on healthy eating and lifestyle, or patients purchasing and using incretin agonists through consumer channels, but possibly at subtherapeutic doses. Vigilance and probing are key here, but health systems will need to train more people on the types of probing that uncover underlying issues and behaviors that patients mistakenly believe to be healthy. 00:21:02 - Newsmakers: Aleksander Krag and Stine Johansen discuss Screening for Advanced Liver DiseaseLast month, The Lancet posted online an article from Stine Johansen, Fredrik Åberg, Emmanuel Tsochatzis and Aleksander Krag, titled "Screening for Advanced Liver Disease." The article aims to update the Wilson and Jungner criteria, originally developed in 1960, to address modern needs and issues. In this conversation, Professor Krag and Dr. Johansen join Roger Green to discuss their article. There are many nuances and high points to cover in this thoughtful, fairly lengthy conversation, but the key point is that screening a mass population for HCC or cirrhosis has an entirely different set of issues and criteria compared to the screening usually discussed on this podcast, which involves identifying a population at increased risk for MASLD or MASH and screening them. 00:54:42 - Major Issues of the First Six Months: Changes in US Health Policy and Potential for Dynamism in the In-Office Scanning Market Roger drives this conversation, focusing on two very different, yet very important issues: the first is the increasing dynamism of the in-office scanning market, with leader Echosens developing new products and services, while companies like e-Scopics, Sonic Incytes, and Mindray (Hepatus) are introducing new devices with competing profiles. Roger discusses the idea that some scanners keep all data resident in the machine, while others send it immediately to the cloud. Louise suggests that we should welcome any reliable scanning device to the market. Separately, he lists some concerns about how the Trump Administration's focus on cutting services to the poor, coupled with Robert F. Kennedy Jr.'s distrust of pharmaceuticals and mainstream health research, might limit the number of Americans with access to healthcare and the kinds of care they can access. At the end of this conversation, Roger asks Jörn and Louise what they consider major issues for the next six months.01:11:40 - Business Report and Wrap-Up

Welcome back to the Hot Topics podcast from NB Medical with Dr Neal Tucker. In this new season, we chat to Dr Simon Curtis about the upcoming Autumn 2025 Hot Topics course, then discuss three new pieces of research.First, in the Lancet, which are the best anti-hypertensives, what effect does increasing a dose actually have and how good are combinations? Second, in the NEJM, does giving all the drugs improve CKD outcomes? The case for finerenone and empagliflozin. Third, do ADHD drugs help outcomes beyond core symptoms such as accidents, suicide and crime? But can we rely on the research method used...?ReferencesLancet Antihypertensive Efficacy PaperNEJM Finerenone & EmpagliflozinReport on trends in CKDBMJ ADHD meds & prevention of complicationswww.nbmedical.com/podcast

Climate Education for YouthClimate education has the potential to drive the public towards climate science literacy, an individual's understanding of their influence on climate and climate's influence on them and society. According to the National Oceanic and Atmospheric Administration, a climate-literate person: understands the essential principles of Earth's climate system,knows how to assess scientifically credible information about climate,communicates about climate and climate change in a meaningful way, andis able to make informed and responsible decisions with regard to actions that may affect climate.Climate change education is more than just science education; it is an interdisciplinary topic that involves understanding the relationship between climate change, history, economics, social studies, and more. A robust and interdisciplinary climate education provides an understanding of the large-scale social transformation necessary to increase climate resiliency and implement effective solutions.Empowering Future Solution Makers Climate education can provide younger generations with the knowledge, skills, attitudes, and values that are necessary to make more environmentally informed decisions. By equipping students with a thorough understanding of climate science and illuminating the scientific process utilized by climate scientists, students become armed to critically assess climate discourse and solutions. Moreover, climate education fosters a sense of agency: youth may grow up to vote for climate positive policies, pursue careers that strive towards climate solutions, have a more eco-conscious lifestyle, or facilitate constructive conversations with family members and friends. Implementing effective climate solutions relies on an informed public, and climate education provides youth with a starting point to act as agents of positive change amidst our planetary emergency. Additionally, climate education can provide youth with the tools necessary to alleviate and cope with climate anxiety. A 2021 Lancet Study asked 10,000 young people between the ages of 16–25 in ten countries what they felt about climate change, and found that more than 50% of young people reported experiencing sadness, anxiety, anger, powerlessness, helplessness, and guilt. Effective climate education will not only help youth understand the causes and impacts of climate change, but it will also provide young people with insight on how they can contribute to solutions and exercise their own agency to make meaningful changes. Further, climate education can provide coping strategies by fostering hope and highlighting the collective efforts being made to address climate change. Barriers to Effective Climate Education According to an article from Science, data from 1500 public middle- and high-school science teachers from all 50 US states found that the median teacher devotes only one to two hours to climate change instruction. Climate confusion among U.S. teachers further contributes to this educational gap within American education, and limited training and scientific consensus among teachers leads to mixed messages. For example, the research published in Science found that of the teachers who teach climate change, “31% report sending explicitly contradictory messages, emphasizing both the scientific consensus that recent global warming is due to human activity and that many scientists believe recent increases in temperature are due to natural causes.” Progress in climate science and scientific consensus have outpaced teachers' training. Additionally, teachers may face political threats and external pressures from parents or administration to avoid climate instruction. Teachers' lack of knowledge on climate science and exclusion of climate instruction is further compounded by variations in learning standards and requirements. Climate education within the US faces challenges due to the absence of consensus on the inclusion of climate change in educational curricula and the absence of national science standards on the subject. In 2013, the Next Generation Science Standards (NGSS) were developed and recommended that human-made climate change be taught in all science classes beginning in fifth grade. However, these standards remain voluntary, and 44 states have used the NGSS or created standards based on them. Since 2007, The Campaign for Environmental Literacy has continued to organize stakeholders and push for passage of the Climate Change Education Act, leading to the subsequent efforts to reintroduce and pass the bill four times since then. Despite these efforts, federal grants to fund climate change education projects have been miniscule and initiatives in Congress to support climate change education have been unsuccessful. New Jersey became a pioneer in climate education in 2020, becoming the first state to mandate the teaching of climate change beginning in kindergarten. Notably, New Jersey has taken an interdisciplinary approach to climate education as students are learning about climate change in ceramics and physical education classes. Making Climate Change Education Accessible and Engaging for YouthOutside of the traditional classroom setting, many environmental organizations, activists, content creators, and informal education institutions like museums or zoos provide opportunities for students to engage in climate education. Collectively, these actors play critical roles as environmental educators who bridge the educational gaps related to climate change and increase climate literacy amongst young people. In an era dominated by digital communication, media serves as a dynamic and influential tool in climate education initiatives. In a survey conducted by the EdWeek Research Center, social media emerged as the third most frequently mentioned source of information on climate change amongst teenagers. Young people consume climate-related media through various social media platforms, like YouTube, Instagram, and TikTok. Environmental educators understand that leveraging various forms of media allows them to create engaging, relatable, and inspiring climate education for today's youth. While leveraging these platforms to educate youth and the wider public on climate change, storytelling remains a central element. Media-driven climate education empowers environmental educators to effectively break down barriers and make climate science more accessible, relatable, and inspiring for youth of all ages. Who is Suzie Hicks?Suzie Hicks is an award-winning filmmaker, author and television host specializing in environmental communication for kids of all ages. Suzie emphasizes the power of children's media and learning communities, connecting youth advocates and educator allies. Their current project includes “Suzie Hicks the Climate Chick,” which started out as a college-produced Studio TV series, then transformed into a preschool teaching persona, a social media account, and now an award-winning children's pilot. “Suzie Hicks the Climate Chick” aims to educate everyone about the local impacts and solutions of climate change through puppetry, comedy, and music. ResourcesSuzie Hicks Website United Nations, Education is key to addressing climate changeNOAA, What is Climate Science Literacy?Hickman et al., Climate anxiety in children and young people and their beliefs about government responses to climate change: a global survey (The Lancet, 2021)Plutzer et al., Climate Confusion Among U.S. Teachers (Science, 2016)Renee Cho, Climate Education in the U.S.: Where It Stands, and Why It Matters (Columbia Climate School, 2023)Next Generation Science Standards (NGSS)Seyma Bayram, New Jersey requires climate change education. A year in, here's how it's going (NPR, 2023).Arianna Prothero, Most Teens Learn About Climate Change From Social Media. Why Schools Should Care (EdWeek, 2023)Cleary Vaughan-Lee, Executive Director of Global Oneness Project, Immersive Storytelling and Climate Change: Fostering the Development of Social-Emotional Learning (UNESCO Mahatma Gandhi Institute of Education for Peace and Sustainable Development)For a transcript of this episode, please visit https://climatebreak.org/educating-kids-about-climate-change-through-musical-storytelling/

Gavin, Richard, and Jessamy enter the studio once more for a Lancet Voice chat. A new book on Alzheimer's disease causes controversy across the Lancet team, we discuss the new Countdown on Plastics & Health, and a quick look at the problems facing the upcoming UN High Level Meeting on NCDs.You can read the Lancet Countdown on health and plastics here:https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)01447-3/fulltext?dgcid=buzzsprout_tlv_podcast_August_25_lancetSend us your feedback!Read all of our content at https://www.thelancet.com/?dgcid=buzzsprout_tlv_podcast_generic_lancetCheck out all the podcasts from The Lancet Group:https://www.thelancet.com/multimedia/podcasts?dgcid=buzzsprout_tlv_podcast_generic_lancetContinue this conversation on social!Follow us today at...https://thelancet.bsky.social/https://instagram.com/thelancetgrouphttps://facebook.com/thelancetmedicaljournalhttps://linkedIn.com/company/the-lancethttps://youtube.com/thelancettv

Send us a Text Message (please include your email so we can respond!)Episode 72! We continue talking about the articles from the CCR25 conference with UK-ROX or "Conservative Oxygen Therapy in Mechanically Ventilated Critically Ill Adult Patients" published in JAMA 2025 by Martin et al and TARGET-Protein or "Sodium bicarbonate therapy for patients with severe metabolic acidaemia in the intensive care unit" by Jaber et al in Lancet 2018.UK-ROX: https://pubmed.ncbi.nlm.nih.gov/40501321/UK-ROX (JAMA): https://jamanetwork.com/journals/jama/article-abstract/2835384TARGET-Protein: https://pubmed.ncbi.nlm.nih.gov/40495743/TARGET-Protein (JAMA): https://jamanetwork.com/journals/jama/article-abstract/2835302If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

IQBAR is offering our special podcast listeners 20% OFF all IQBAR products, plus get FREE shipping. To get your 20% off, text VANESSA to 64000. That's VANESSA to sixty-four thousand. Message and data rates may apply. See terms for details. In today's episode, Vanessa sits down with Dr. Samuel Dicken, Research Fellow at University College London's Centre for Obesity Research and lead author of the UPDATE Trial — the longest and most rigorous clinical study to date comparing ultra-processed (UPF) vs. minimally processed (MPF) diets. This landmark trial revealed a game-changing finding:

Ralph welcomes Ben Cohen (anti-war activist and ice cream entrepreneur) to discuss his new campaign, "Up in Arms," which advocates for a common-sense Pentagon budget. Then, Ralph speaks to Guardian columnist Arwa Mahdawi about her recent piece: "When will we finally admit: the Gaza death toll is higher than we've been told."Ben Cohen is an entrepreneur, philanthropist, and longtime anti-war activist. He is a co-founder of the ice cream company Ben & Jerry's and a prominent supporter of progressive causes. He is co-founder of Up In Arms, a public education and advocacy campaign pushing for a common-sense approach to military budgeting. In May of this year, Ben was arrested by Capitol Police after he interrupted Robert F. Kennedy Jr.'s testimony by screaming,”Congress kills poor kids in Gaza by buying bombs and pays for it by kicking kids off Medicaid.”We're up in arms because the government has taken the kindness, the heart, the soul of the American people and essentially replaced it with so many bombs that there's no rational use for them. They've turned us all into mass murderers.Ben CohenYou know, politicians starting from Reagan are fond of saying “a nuclear war cannot be won and must never be fought.” And then they turn around and spend $100 billion a year on a nuclear arsenal that's capable of blowing up the entire world several times over. So they say one thing and they do another. I mean, a nuclear arsenal capable of blowing up the entire world several times over? That's not deterrence. That's delusion.Ben CohenI just go back to the moral issue of our time, which is Gaza—two-thirds of the American people don't support continuing to arm Israel. And we need to make our politicians pay the price for continuing to arm Israel… We have a midterm election coming up. If your guy voted to continue to essentially facilitate the genocide, vote them out.Ben CohenWhen you have more money than is needed, you tend to invite corruption, cost overruns, machinery that doesn't work, and I would advise that you look into why the GAO and the Pentagon auditors are being asked to do fewer audits of the military budget. Because there's almost a direct correlation between throwing money at a government program (especially at that scale) and corruption. And corruption is understandable to everybody. It's the number one political issue all over the world, when the pollsters poll.Ralph NaderArwa Mahdawi is a columnist for the Guardian and author of Strong Female Lead: Lessons from Women in Power. Here is her recent piece on the genocide in Gaza: “When will we finally admit: the Gaza death toll is higher than we've been told” (The Guardian, August 8, 2025)To be fair, the New York Times, Washington Post, and Wall Street Journal have published some pretty devastating reports from their reporters in that area. They've put out some devastating features on what's going on [in Gaza], but it doesn't translate into editorial denunciation by these papers. And it doesn't translate into taking the next step and doing what they would do in other conflicts around the world where there isn't so much prejudice and domestic pressureRalph NaderI'm an opinion writer, but as journalists, you're always supposed to report facts. And the fact is: we have absolutely no idea how many people are dead in the Gaza Strip. But there are plenty of studies (which I reference in the article—one Lancet peer-reviewed study, one letter to the Lancet by a highly-respected scientist, one empirical study by Michael Spagat) which show that the death count is a lot higher. So I truly believe that unless you're saying “the official figure from the Ministry of Health is around 60,000 but studies show it is probably much higher,” then that's just journalistic malpractice.Arwa MahdawiI think there's just this instinct to believe that Palestinians are lying and Israelis are telling the truth. And it also goes back to…this isn't just Israel's war, this is America's war as well. And this desire to see America as the good guys—we're the good guys, the Palestinians are the bad guys. And to have this black-and-white narrative where, obviously, we're the good guys, you know, and so if the Palestinian narrative casts doubt on that, then it must be wrong.Arwa MahdawiI always suggest that people write to the media outlets and say that they want to see more Palestinian narratives, they want the media outlets to voice their concern that foreign reporters are not being let in, that more aid workers are not being let in, that pictures are not coming out.Arwa MahdawiThere are very few pictures coming out of the scale of this destruction in Gaza, but when you see the ones that do come out, it is very, very obvious that there are more than 60,000 people dead.But there seems to be this lack of curiosity with some of my peers. Why aren't they asking, “Why aren't we seeing more pictures?” There should be nonstop outrage that their press freedom is being stifled like this and so many Palestinian journalists are being slaughtered.Arwa MahdawiNews 8/22/25* Last Thursday, during an event in her Masscusetts congressional district, Congresswoman Katherine Clark – who holds the position of House Minority Whip, making her the number two Democrat in the House – called Israel's campaign in Gaza a “genocide,” per Axios. According to Zeteo, this makes Clark the 14th member of Congress to use the “g word.” Lest she be accused of bravery however, Clark quickly walked back her comments. In a statement to the Jewish News Syndicate, Clark said “last week, while attending an event in my district, I repeated the word ‘genocide' in response to a question…I want to be clear that I am not accusing Israel of genocide.” This incident illustrates the cross-cutting pressures facing Democratic Party leaders. This divide will be on the agenda again at the DNC meeting on August 26th, where among other issues, party leaders will vote on competing resolutions to lay out the Democrats' position on Gaza. Allison Minnerly, the progressive DNC delegate sponsoring the resolution to end arms shipments to Israel, is quoted saying “Our voters…are saying that they do not want U.S. dollars to enable further death and starvation anywhere across the world, particularly in Gaza…I don't think it should be a hard decision for us to say that clearly,” per the Intercept.* Even as Democrats wrestle with their position on Gaza, the politics are clearly shifting. The Reject AIPAC coalition has released a new statement saying that among Democrats, AIPAC is now a “toxic pariah.” As evidence of this, Reject AIPAC cites the fact that only 14 House Democrats attended the AIPAC-sponsored Israel trip this year. According to Mondoweiss, “In 2023, the lobbying group brought 24 House Dems to Israel over recess. In 2019, over 40 attended.” Reject AIPAC also cites the fact that Reps. Valerie Foushee and Maxine Dexter, both recipients of millions of AIPAC dollars, voted to block arms to Israel and Foushee is even now rejecting AIPAC money. As these small victories mount, the horizon of possibility for movement within the party grows ever wider.* Last week, Tom Artiom Alexandrovich – a senior department head in Israel's National Cyber Directorate – was arrested in a “multi-agency operation targeting child sex predators,” in Clark County, Nevada according to the Las Vegas Metropolitan Police Department. According to Reuters, “Alexandrovich faces a felony charge of luring or attempting to lure a child or mentally ill person to commit a sex act ‘with use of computer technology.'” Yet, inexplicably, Alexandrovich was released by U.S. authorities and is back in Israel. This set off a firestorm in the U.S., with many accusing the Trump administration of facilitating Alexandrovich's release. The State Department was forced to issue a statement denying these claims, stating that Alexandrovich "did not claim diplomatic immunity and was released by a state judge…Any claims that the U.S. government intervened are false." The AP adds that the “Israeli Embassy in Washington and the Israeli Prime Minister's Office did not immediately return messages.” Disturbingly, the mainstream media seems to be purposely ignoring this case. While it has been covered by the Guardian, the Times of Israel, and Haaretz, there has been zero coverage in the New York Times or Washington Post, or ABC, NBC, or CBS. This media blackout adds fuel to the speculation that this case is being tamped down by the administration for political reasons.* Another troubling story regarding minors on the internet comes to us from Mark Zuckerberg's Meta AI. According to Reuters, internal documents from Meta Platforms detail “policies on chatbot behavior…[permitting] the company's artificial intelligence creations to ‘engage a child in conversations that are romantic or sensual,' generate false medical information and help users argue that Black people are ‘dumber than white people.'” Former Federal Trade Commission Chair Lina Khan called these reports “disturbing” and cited a legal complaint filed by the FTC to the Justice Department against Snap in January, under her leadership, “charging that [Snap's] AI chatbot was creating risks and harms for young users.” Khan noted that the “DOJ hasn't filed the case or taken any steps to protect these kids,” and demanded that “Any lawmaker concerned about big tech's abuse of kids should ask what is going on.” The administration's lack of action on these issues indicates that despite their rhetorical inveighing against the tech industry, they are treating SIlicon Valley with the same kid gloves they use for the rest of corporate America, even when it affects minors.* In more positive news from abroad, the Washington Post reports that between 2022 and 2024, Mexico lifted a stunning 8.3 million residents out of poverty. This 18% drop in poverty includes a 23% decrease in extreme poverty and a 16% drop in moderate poverty. According to experts, this remarkable achievement is the result of the policies of former President Andres Manuel Lopez Obrador, or AMLO, and his successor Claudia Sheinbaum, such as tripling the minimum wage and instituting a raft of social programs to aid “senior citizens, unemployed youth, students, farmers and people with disabilities.” President Sheinbaum is now plowing ahead with a new project – producing a “small, 100% electric, accessible [EV],” called the “Olinia,” to be fully manufactured and assembled in Mexico, per Mexico News Daily.* Turning to domestic politics, Congresswoman Elise Stefanik finally showed up in her district on Monday after an extended period of avoiding public appearances. At a ceremony honoring a late Clinton County clerk in Plattsburgh, Stefanik was drowned out by cries of “‘You sold us out!', ‘Shame!', and ‘Unseal the Epstein files!', along with a “steady stream of boos,” according to the Daily Beast. Stefanik “left the podium after speaking for less than a minute,” and when she returned, she was booed again. Stefanik's chronic absence and chilly reception is a bad sign for her gubernatorial aspirations. In the months since she has held a town hall, her constituents held a mock town hall where they addressed an empty chair, per WRGB, and New York Democrats AOC and Paul Tonko held town halls in her district, per the Albany Times-Union.* In more political news from New York, disgraced former Governor Andrew Cuomo is explicitly seeking to woo New York Republicans in his independent bid for Mayor of New York City. POLITICO reports that at a fundraiser at media mogul Jimmy Finkelstein's Southampton estate, Cuomo told the crowd that he agrees with President Trump that the “goal is to stop Mamdani.” To this end, he is trying to convince Republicans that they would be “wasting [their] vote on [Curtis] Sliwa,” the Republican nominee for Mayor, “because he'll never be a serious candidate.” Cuomo also implied that he is open to an alliance with Trump, telling the crowd “Let's put it this way: I knew the president very well.” Dora Pekec, a spokesperson for the Zohran campaign, is quoted saying “Since he's too afraid to say it to New Yorkers' faces, we'll make it clear: Andrew Cuomo IS Donald Trump's choice for mayor.”* In Texas, state Democrats have returned to the state, ending their attempt to defeat Governor Abbott's mid-decade redistricting scheme by denying the legislature a quorum. In a statement Gene Wu, chairman of the Texas House Democratic Caucus, said "We killed the corrupt special session, withstood unprecedented surveillance and intimidation, and rallied Democrats nationwide to join this existential fight for fair representation — reshaping the entire 2026 landscape," per the BBC. The legislature is now expected to approve the redrawn congressional maps; the state Democrats plan to continue fighting them in the courts. California has vowed to redraw their own maps to compensate for the expected loss of five Democrat-held seats in Texas. New York, New Jersey, New Hampshire and Maryland are also considering their own redistricting plans. Vice President JD Vance was deployed to Indiana to pressure Republicans in that state to redraw their maps to favor Republicans as well, per the IndyStar. It is a sad state of affairs that American politics has been reduced to such naked power grabbing plots, but here we are.* In local news, the federal occupation of Washington, D.C. continues to deepen. CBS reports the governors of at least six Republican-led states are sending contingents from their National Guards to the capital. These include Mississippi and Louisiana, West Virginia, South Carolina, Ohio and Tennessee. Just what these troops will do in Washington remains unclear. Tennessee Governor Bill Lee, who is sending 160 troops, cited “monument security” and “traffic control” among their official responsibilities. The federal agents on the ground, with little to do – the DOJ itself reports as violent crime is at a 30-year low in the District – seem to be mostly just harassing residents. The Daily Beast reports ICE tore down a banner and replaced it with a dildo. A local, Amanda Moore, posted a photo of 15 federal agents calling an ambulance for a drunk girl in Dupont Circle. And, while the Lever reports D.C. corporate lobbyists pushed for the occupation, it is wreaking havoc on local businesses; Rolling Stone reports reservations at D.C. restaurants are down between 25 and 31%, to take just one example. We can only hope that this pointless, destructive farce of quasi-fascistic political theater ends sooner rather than later.* Finally, investigative reporter and Iraq war veteran Seth Harp is out with a new book – The Fort Bragg Cartel: Drug Trafficking and Murder in the Special Forces – which details the double murder of Master Sergeant Billy Lavigne and Chief Warrant Officer Timothy Dumas, along with the “many more unexplained deaths…other murders connected to drug trafficking in elite units, and dozens of fatal overdoses,” at Fort Bragg in North Carolina. Among other remarkable discoveries, Harp “describes a U.S. special forces k9 [unit] that was given titanium dentures and encouraged to feast on human brains in the field,” in the words of publisher and producer Chris Wade. Remember these titanium dentures whenever you hear that there is no money to pay for critical social programs. The money is there. The political will is not.This has been Francesco DeSantis, with In Case You Haven't Heard. Get full access to Ralph Nader Radio Hour at www.ralphnaderradiohour.com/subscribe

Drs. Whitney Hartlage (@whithartlage11) and Sam Windham join Dr. Ryan Moenster to discuss updates in the diagnosis and management of community-acquire pneumonia. Hear from our guests on the role of rapid diagnostic tests such as multiplex PCR and urinary antigen tests in the inpatient and outpatient setting, considerations for initiating steroids and withholding macrolides, and when to use short antibiotic durations. Listen to Breakpoints on iTunes, Overcast, Spotify, Listen Notes, Player FM, Pocket Casts, TuneIn, Blubrry, RadioPublic, or by using our RSS feed: https://sidp.pinecast.co/. Visit our website! https://breakpoints-sidp.org/ References: Metlay JP, Waterer GW, Long AC, Anzueto A, Brozek J, Crothers K, Cooley LA, Dean NC, Fine MJ, Flanders SA, Griffin MR, Metersky ML, Musher DM, Restrepo MI, Whitney CG. Diagnosis and Treatment of Adults with Community-acquired Pneumonia. An Official Clinical Practice Guideline of the American Thoracic Society and Infectious Diseases Society of America. Am J Respir Crit Care Med. 2019 Oct 1;200(7):e45-e67. doi: 10.1164/rccm.201908-1581ST. PMID: 31573350; PMCID: PMC6812437. Chaudhuri D, Nei AM, Rochwerg B, Balk RA, Asehnoune K, Cadena R, Carcillo JA, Correa R, Drover K, Esper AM, Gershengorn HB, Hammond NE, Jayaprakash N, Menon K, Nazer L, Pitre T, Qasim ZA, Russell JA, Santos AP, Sarwal A, Spencer-Segal J, Tilouche N, Annane D, Pastores SM. 2024 Focused Update: Guidelines on Use of Corticosteroids in Sepsis, Acute Respiratory Distress Syndrome, and Community-Acquired Pneumonia. Crit Care Med. 2024 May 1;52(5):e219-e233. doi: 10.1097/CCM.0000000000006172. Epub 2024 Jan 19. PMID: 38240492. Odeyemi Y, Tekin A, Schanz C, Schreier D, Cole K, Gajic O, Barreto E. Comparative effectiveness of azithromycin versus doxycycline in hospitalized patients with community acquired pneumonia treated with beta-lactams: A multicenter matched cohort study. Clin Infect Dis. 2025 May 16:ciaf252. doi: 10.1093/cid/ciaf252. Epub ahead of print. PMID: 40378193. Butler AM, Nickel KB, Olsen MA, Sahrmann JM, Colvin R, Neuner E, O'Neil CA, Fraser VJ, Durkin MJ. Comparative safety of different antibiotic regimens for the treatment of outpatient community-acquired pneumonia among otherwise healthy adults. Clin Infect Dis. 2024 Oct 23:ciae519. doi: 10.1093/cid/ciae519. Epub ahead of print. PMID: 39442057; PMCID: PMC12355227. Furukawa Y, Luo Y, Funada S, Onishi A, Ostinelli E, Hamza T, Furukawa TA, Kataoka Y. Optimal duration of antibiotic treatment for community-acquired pneumonia in adults: a systematic review and duration-effect meta-analysis. BMJ Open. 2023 Mar 22;13(3):e061023. doi: 10.1136/bmjopen-2022-061023. PMID: 36948555; PMCID: PMC10040075 Schober T, Wong K, DeLisle G, et al. Clinical outcomes of rapid respiratory virus testing in emergency departments. JAMA Intern Med. 2024;184(5):528-536. Clark T, Lindsley K, Wigmosta T, et al. Rapid multiplex PCR for respiratory viruses reduces time to result and improves clinical care: results of a systematic review and meta-analysis. J Infect. 2023;86(5):462-475. May L, Robbins EM, Canchola JA, Chugh K, Tran NK. A study to assess the impact of the cobas point-of-care RT-PCR assay (SARS-CoV-2 and Influenza A/B) on patient clinical management in the emergency department of the University of California at David Medical Center. J Clin Virol. 2023:168:105597. Cartuliares MB, Rosenvinge FS, Mogensen CB, Skovsted TA, Andersen SL, Østergaard C, et al. Evaluation of point-of-care multiplex polymerase chain reaction in guiding antibiotic treatment of patients acutely admitted with suspected community-acquired pneumonia in Denmark: a multicentre randomised controlled trial. PLoS Med. 2023;20:e1004314. doi: 10.1371/ journal.pmed.1004314. Vaughn VM, Dickson RP, Horowitz JK, Flanders SA. Community-acquired pneumonia: a review. JAMA. 2024;332(15):1282-1295. Davis MR, McCreary EK, Trzebucki AM. Things we do for no reason – ordering Streptococcus pneumoniae urinary antigen in patients with community-acquired pneumonia. Open Forum Infect Dis. 2024;11(3):ofae089. Centers for Disease Control and Prevention. Laboratory Testing for Legionella. Updated June 9, 2025. Accessed July 13, 2025. https://www.cdc.gov/legionella/php/laboratories/index.html. Jain S, Self WH, Wunderink RG. Community-acquired pneumonia requiring hospitalization among U.S. adults. N Engl J Med. 2015;373(5):415-427. Kamat IS, Ramachandram V, Eswaran H, Guffey D, Musher DM. Procalcitonin to distinguish viral from bacterial pneumonia: a systematic review and meta-analysis. Clin Infect Dis. 2020;70(3):538-542. Christ-Crain M, Jaccard-Stolz D, Bingisser R, Gencay MM, Huber PR, Tamm M, et al. Effect of procalcitonin-guided treatment on antibiotic use and outcome in lower respiratory tract infections: cluster-randomised, single blinded intervention trial. Lancet. 2004;363:600–7. doi: 10.1016/S0140- 6736(04)15591-8. Schuetz P, Christ-Crain M, Thomann R, Falconnier C, Wolbers M, Widmer I, et al. Effect of procalcitonin-based guidelines vs standard guidelines on antibiotic use in lower respiratory tract infections: the ProHOSP randomized controlled trial. JAMA. 2009;302:1059–66. Schuetz P, Muller B, Christ-Crain M, Stolz D, Tamm M, Bouadma L, et al. Procalci- € tonin to initiate or discontinue antibiotics in acute respiratory tract infections. Cochrane Datab System Rev. 2017;10(10):CD007498. doi: 10.1002/14651858. cd007498.pub2. Huang DT, Yealy DM, Filbin MR, Brown AM, Chang C-CH, Doi Y, et al. Procalcitonin-guided use of antibiotics for lower Respiratory tract infection. New Engl J Med. 2018;379:236–49. doi: 10.1056/NEJMoa1802670. Dequin PF, Meziani F, Quenot JP, et al. Hydrocortisone in severe community-acquired pneumonia. N Engl J Med. 2023;389(19):1623-1634. doi:10.1056/NEJMoa2215145. Gupta AB, Flanders SA, Petty LA, et al. Inappropriate diagnosis of pneumonia among hospitalized adults. JAMA Intern Med. 2024;184(5):548-556. Jones BE, Chapman AB, Ying J, et al. Diagnostic Discordance, Uncertainty, and Treatment Ambiguity in Community-Acquired Pneumonia: A National Cohort Study of 115 U.S. Veterans Affairs Hospitals. Ann Intern Med. 2024;177(9):1179-1189. doi:10.7326/M23-2505. Hartlage W, Imlay H, Spivak ES. The role of empiric atypical antibiotic coverage in non-severe community-acquired pneumonia. Antimicrob Steward Healthc Epidemiol. 2024;4(1):e214. doi:10.1017/ash.2024.453. Dinh A, Barbier F, Bedos JP, et al. Update of guidelines for management of community acquired pneumonia in adults by the French Infectious Disease Society (SPILF) and the French-Speaking Society of Respiratory Diseases (SPLF). Endorsed by the French Infectious Disease Society (SPILF) and the French-Speaking Society of Respiratory Diseases (SPLF); endorsed by the French Intensive Care Society (SRLF), the French Microbiology Society (SFM), the French Radiology Society (SFR), and the French Emergency Society (SFMU). Respir Med and Res. 2025. El Moussaoui R, de Borgie CAJM, van den Broek P, et al. Effectiveness of discontinuing antibiotic treatment after three days versus eight days in mild to moderate-severe community acquired pneumonia: randomised, double blind study. BMJ. 2006;332(7554):1355. doi:10.1136/bmj.332.7554.1355. Dinh A, Ropers J, Duran C, et al. Discontinuing β-lactam treatment after 3 days for patients with community-acquired pneumonia: a randomized, non-inferiority trial. Lancet. 2021;397(10280):1195-1203.

******Support the channel******Patreon: https://www.patreon.com/thedissenterPayPal: paypal.me/thedissenterPayPal Subscription 1 Dollar: https://tinyurl.com/yb3acuuyPayPal Subscription 3 Dollars: https://tinyurl.com/ybn6bg9lPayPal Subscription 5 Dollars: https://tinyurl.com/ycmr9gpzPayPal Subscription 10 Dollars: https://tinyurl.com/y9r3fc9mPayPal Subscription 20 Dollars: https://tinyurl.com/y95uvkao ******Follow me on******Website: https://www.thedissenter.net/The Dissenter Goodreads list: https://shorturl.at/7BMoBFacebook: https://www.facebook.com/thedissenteryt/Twitter: https://x.com/TheDissenterYT This show is sponsored by Enlites, Learning & Development done differently. Check the website here: http://enlites.com/ Dr. Kristen Ghodsee is an award-winning author and professor and chair of Russian and East European Studies at the University of Pennsylvania. She also serves as a member on the graduate groups of Anthropology and Comparative Literature. Dr. Ghodsee's articles and essays have been translated into over twenty-five languages and have appeared in publications such as Dissent, Foreign Affairs, Jacobin, The Baffler, The New Republic, Quartz, NBC Think, The Lancet, Project Syndicate, Le Monde Diplomatique, Die Tageszeitung, The Washington Post, and the New York Times. She is the author of 12 books, including Everyday Utopia: What 2,000 Years of Wild Experiments Can Teach Us About the Good Life. In this episode, we focus on Everyday Utopia. We first discuss what is a “utopia”, social experiments in the 18th and 19th centuries, and Pythagoras. We talk about family and gender roles, the cohousing movement in Denmark, the Israeli kibbutzim, matriarchal Colombian ecovillages, planned microdistricts in China, and monastic life. We also discuss the importance of education, communism, what we can learn by studying these societies, and the difficulties in implementing utopia.--A HUGE THANK YOU TO MY PATRONS/SUPPORTERS: PER HELGE LARSEN, JERRY MULLER, BERNARDO SEIXAS, ADAM KESSEL, MATTHEW WHITINGBIRD, ARNAUD WOLFF, TIM HOLLOSY, HENRIK AHLENIUS, ROBERT WINDHAGER, RUI INACIO, ZOOP, MARCO NEVES, COLIN HOLBROOK, PHIL KAVANAGH, SAMUEL ANDREEFF, FRANCIS FORDE, TIAGO NUNES, FERGAL CUSSEN, HAL HERZOG, NUNO MACHADO, JONATHAN LEIBRANT, JOÃO LINHARES, STANTON T, SAMUEL CORREA, ERIK HAINES, MARK SMITH, JOÃO EIRA, TOM HUMMEL, SARDUS FRANCE, DAVID SLOAN WILSON, YACILA DEZA-ARAUJO, ROMAIN ROCH, DIEGO LONDOÑO CORREA, YANICK PUNTER, CHARLOTTE BLEASE, NICOLE BARBARO, ADAM HUNT, PAWEL OSTASZEWSKI, NELLEKE BAK, GUY MADISON, GARY G HELLMANN, SAIMA AFZAL, ADRIAN JAEGGI, PAULO TOLENTINO, JOÃO BARBOSA, JULIAN PRICE, HEDIN BRØNNER, DOUGLAS FRY, FRANCA BORTOLOTTI, GABRIEL PONS CORTÈS, URSULA LITZCKE, SCOTT, ZACHARY FISH, TIM DUFFY, SUNNY SMITH, JON WISMAN, WILLIAM BUCKNER, LUKE GLOWACKI, GEORGIOS THEOPHANOUS, CHRIS WILLIAMSON, PETER WOLOSZYN, DAVID WILLIAMS, DIOGO COSTA, ALEX CHAU, CORALIE CHEVALLIER, BANGALORE ATHEISTS, LARRY D. LEE JR., OLD HERRINGBONE, MICHAEL BAILEY, DAN SPERBER, ROBERT GRESSIS, JEFF MCMAHAN, JAKE ZUEHL, BARNABAS RADICS, MARK CAMPBELL, TOMAS DAUBNER, LUKE NISSEN, KIMBERLY JOHNSON, JESSICA NOWICKI, LINDA BRANDIN, VALENTIN STEINMANN, ALEXANDER HUBBARD, BR, JONAS HERTNER, URSULA GOODENOUGH, DAVID PINSOF, SEAN NELSON, MIKE LAVIGNE, JOS KNECHT, LUCY, MANVIR SINGH, PETRA WEIMANN, CAROLA FEEST, MAURO JÚNIOR, 航 豊川, TONY BARRETT, NIKOLAI VISHNEVSKY, STEVEN GANGESTAD, TED FARRIS, HUGO B., JAMES, JORDAN MANSFIELD, CHARLOTTE ALLEN, PETER STOYKO, DAVID TONNER, LEE BECK, PATRICK DALTON-HOLMES, NICK KRASNEY, AND RACHEL ZAK!A SPECIAL THANKS TO MY PRODUCERS, YZAR WEHBE, JIM FRANK, ŁUKASZ STAFINIAK, TOM VANEGDOM, BERNARD HUGUENEY, CURTIS DIXON, BENEDIKT MUELLER, THOMAS TRUMBLE, KATHRINE AND PATRICK TOBIN, JONCARLO MONTENEGRO, NICK GOLDEN, CHRISTINE GLASS, IGOR NIKIFOROVSKI, PER KRAULIS, AND JOSHUA WOOD!AND TO MY EXECUTIVE PRODUCERS, MATTHEW LAVENDER, SERGIU CODREANU, ROSEY, AND GREGORY HASTINGS!

Dr. Dan Ackerman talks with Dr. Urs Fischer about the optimal timing of anticoagulation after ischemic stroke in patients with atrial fibrillation.  Read the related article in The Lancet.  Disclosures can be found at Neurology.org.   

Mark Weisbrot and Francisco Rodríguez join us to discuss their Lancet article, co-authored with Silvio Rendón, "Effects of international sanctions on age-specific mortality: a cross-national panel data analysis," and their articles based on that research, "Sanctions can kill as many people as wars" (Financial Times), and "Rethink sanctions. They're killing as many people as war does" (LA Times). "The Moment of Truth" with Jeff Dorchen follows the interview. Check out Mark and Francisco's study, co-authored with Silvio Rendón: https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(25)00189-5/fulltext Check out Mark's article in the LA Times: https://www.latimes.com/opinion/story/2025-07-24/united-states-sanctions-deaths Check out Francisco's article at Financial Times: https://www.ft.com/content/99206b73-92c4-41f1-9677-d4a1e6fc78b1?accessToken=zwAGO8yGY2UgkdOZIGtzksRB8dOWd9Sh5vx4sQ.MEQCIFP6yeUhZIJ4mPS1-GjgdlEcQAaHOOh8YjxiUWaqlMAJAiB5JbhVt6_de4NuKcvk8TCwva2ZtyzJMBscOiQnyHKTiA&sharetype=gift&token=4d21afe8-c829-4682-8cd0-4ea688ff1ca7 (sorry about the long url) Help keep This Is Hell! completely listener supported and access bonus episodes by subscribing to our Patreon: https://www.patreon.com/thisishell Please rate and review This Is Hell! wherever you get your podcasts. It really helps the show ascend the algorithm to reach new listeners.

In Geneva, negotiators from 175 nations are trying to hammer out the first-ever legally binding treaty on plastic pollution. The urgency of the talks was underscored this week by a new study published in The Lancet. It calls plastics a “grave, growing and under-recognized danger to human and planetary health.” John Yang speaks with Tracey Woodruff, one of the study’s authors, to learn more. PBS News is supported by - https://www.pbs.org/newshour/about/funders

Ralph and the crew spend the whole hour with Omer Bartov, professor of Holocaust and genocide studies at Brown University, who grew up in a Zionist home, lived the first half of his life in Israel, served in the I.D.F. as a soldier and officer and is the author a New York Times op-ed entitled “I'm a Genocide Scholar. I Know It When I See It.” Plus, Ralph pays tribute to legendary Washington Post reporter, Morton Mintz.Omer Bartov is a professor of Holocaust and genocide studies at Brown University. He has written widely on modern Germany, France, the Holocaust, and representations of war and genocide. He is the author of the Mirrors of Destruction: War, Genocide, and Modern Identity, and the forthcoming book, Israel: What Went Wrong?, and he's penned a New York Times op-ed entitled “I'm a Genocide Scholar. I Know It When I See It.”I published an op-ed in November 2023, and I said there were war crimes, clearly, crimes against humanity, and this will become genocide if it's not stopped. And the Biden administration at the time did nothing. President Biden could have stopped that within two weeks. The Israeli military machine cannot function for more than two or three weeks without constant supply of munitions, without constant supply of financial help, and most importantly, without a diplomatic Iron Dome, especially in the Security Council.Professor Omer BartovIf you say that you are shutting down speech because of anti-Semitism, who are the people who are pushing that? It must be all kinds of Jewish interests that are pushing that. And in that sense, this false campaign against anti-Semitism – some of whose leaders are people with pretty good anti-Semitic credentials themselves – is the best way to raise, to promote and incite anti-Semitism.Professor Omer BartovThere's no moral responsibility, there's no empathy being shown, and much of the population shares that view. To me, as someone who was raised in Israel, spent half of my life there, served four years in the army, to see my own society (including some of my friends) show this kind of moral callousness is frankly quite heartbreaking. And I have to say, it's the result of a long process. It's not only a response to October 7th, it's the result of six decades of occupation, of thinking of Palestinians as not really people who have any right to have rights or any right to health, to security. And in that sense, that long-term occupation has corrupted much of Israeli society. And maybe the most surprising thing is that there's still extraordinary people there who are fighting against that, but their numbers are diminishing, not growing.Professor Omer BartovMorton Mintz was hands-down the greatest consumer reporter of his generation. He opened up one field after another because he had a special sense of newsworthiness that other reporters and editors didn't have. He opened up the coverage of the pharmaceutical industry. He opened up the coverage of the auto industry. And he did so with such formidable documentation and research that other reporters started following the same subject area. So he was a pioneer.Ralph NaderNews 8/1/25* Crusading environmental lawyer Steven Donziger has published a new report in the left-wing outlet Orinoco Tribune on the undercount of the dead in Gaza. In this piece, Donziger uses the statistical model laid out by the prestigious medical journal The Lancet in their 2024 study on the Israeli military campaign, which found the direct and indirect death toll could be as high as 186,000. The Lancet study found that as many as 732 Gazans died every day from these direct and indirect causes. Multiplied by the 594 days the conflict has dragged on, this would equate to a death toll of 434,800, or 20.7% of the enclave's population. As Donziger notes, “If the same level of killing and indirect death that took place in Gaza…happened in the United States proportional to population, roughly 70 million Americans would have been killed.”* In more Gaza news, the Guardian reports that, “On Saturday night, the…IDF…intercepted and boarded the Handala, an aid ship that attempted to reach Gaza as part of the Freedom Flotilla Coalition…According to the coalition, IDF soldiers beat and choked…labor activist Chris Smalls.” The severity of the attack on Christian Smalls – founder of the independent Amazon Labor Union (ALU) – caused international outcry. From the Guardian report, “Smalls was physically assaulted by seven uniformed individuals. They choked him and kicked him in the legs, leaving visible signs of violence on his neck and back.” The incident also drew criticism for another reason: Smalls was the only Black person on board the Handala. While 21 members of the Flotilla group were detained, in their words ”abducted,” “This level of force was not used.” It is unclear why this level of force was used against Smalls and Smalls alone, other than the color of his skin.* Yet more tragic news from Gaza concerns the death of Odeh Hadalin, the 31-year-old Palestinian activist and English teacher featured in the Oscar-winning documentary No Other Land. Al Jazeera reports that footage taken by Israeli human rights group B'Tselem “appears to show [Israeli settler Yinon] Levi opening fire on Hadalin during a confrontation in the village [of Umm al-Kheir, south of Hebron].” Levi, already sanctioned by the European Union and the United States over past attacks on Palestinians, reportedly told witnesses he was “glad about it.” Despite all of this, an Israeli court has released Levi on house arrest. Basel Adra, who co-directed No Other Land with Yuval Abraham, wrote “This is how Israel erases us — one life at a time.”* One positive development is in progress however. According to the Embassy of France in the United States, "France is prepared to fully recognize the State of Palestine, and will do so in September." French recognition of the Palestinian state, will If it ultimately comes to pass, have major ramifications on the world stage. While 147 member states of the United Nations have recognized Palestine, only 10 out of 27 EU countries have done so, mostly former Eastern Bloc states like Bulgaria, Hungary, Poland, and Romania, along with the former country of Czechoslovakia. The modern country of Slovakia has reaffirmed their recognition; Czechia has not. In 2024, several more European nations extended recognition, including Norway, Slovenia, Ireland and Spain. France however would tip the permanent members of the United Nations Security Council to a 3-2 majority in recognition of Palestine, along with Russia and China. Moreover, AP reports the United Kingdom is now saying they will “recognize a Palestinian state in September unless Israel agrees to a ceasefire in Gaza,” among other conditions. If this happens, The permanent members of the Security Council would be split 4-1, with the United States as the lone holdout. This would be nothing short of an international relations sea change on the question of Palestine.* In some more positive foreign policy news, Jeremy Corbyn's new party in the U.K. is getting started with a bang. According to the man himself, over 600,000 people have signed up to register with the new party, which describes itself as “a new kind of political party. One that is rooted in our communities, trade unions and social movements. One that builds power in all regions and nations. One that belongs to you.” Polls show this new party in the lead among Britons aged 18-24 and Corbyn leading Labour Party leader Keir Starmer by “Almost Every Metric,” among members of the rightwing populist Reform Party. That said, the Reform Party is still projected to win an overwhelming victory compared to all other parties in the next elections, though those are not expected to be held until 2029.* In Congress, Bernie Sanders forced a vote Wednesday on two new Senate resolutions to block arms transfers to Israel. Resolution 34 would “prohibit the U.S.-taxpayer financed $675.7 million sale of 201 MK 83 1,000-pound bombs; 4,799 BLU-110A/B General Purpose 1,000-pound bombs; 1,500 Joint Direct Attack Munition (JDAM) guidance kits for MK 83 bombs; 3,500 JDAM guidance kits for MK 83 bombs; and related logistics and technical support services,” while Resolution 41 would “prohibit the sale of tens of thousands of fully automatic assault rifles.” These resolutions got the support of 27 Senators, a new record and a majority of the Democratic Senate Caucus, but still far, far short of even a simple Senate majority. Perhaps a more portentous development is that Georgia Congresswoman Marjorie Taylor Greene this week became the first Republican in Congress to call the crisis in Gaza a “genocide,” according to the Hill. It remains to be seen whether this will help break the dam on that side of the aisle.* In New York City, new polling shows stunning results for Zohran Mamdani. The new poll conducted by Zenith Research and Public Progress Solutions shows Zohran dominating the 5-way race, earning 50% and beating out the other four candidates combined. Mamdani does even better in head-to-head matches against disgraced former Governor Andrew Cuomo and corruption-dogged incumbent Mayor Eric Adams. The crosstabs are even more astonishing. Despite the breathless and baseless accusations of antisemitism, Zohran is winning 67% of Jews under age 45 and a whopping 85% of men ages 18-34. This second number is key as Democrats struggle to attract young men. One warning sign: a recent Pew poll shows Republicans with an 18-point lead among men in the Gen Z cohort.* In an ominous challenge to the separation of church and state, the Hill reports President Donald Trump released a memo Monday allowing federal employees to “attempt to persuade co-workers about why their religious beliefs are ‘correct.'” This memo cites “crosses, crucifixes and mezuzah,” as displays of religious indicia that should not result in disciplinary action. This bizarre and constitutionally dubious policy seems likely to lead to workplace discord.* In more Trump news, CBS reports Trump has ousted “Two top Justice Department antitrust officials.” According to sources, two deputies to Assistant Attorney General Gail Slater, who leads DOJ antitrust efforts, were “placed on administrative leave last week and fired on Monday for insubordination.” These two figures are Roger Alford, principal deputy assistant attorney general, and Bill Rinner, deputy assistant attorney general and head of merger enforcement. It is not clear why exactly Alford and Rinner were pushed out, but there has apparently been substantial strife within the administration over the antitrust cases against T-Mobile and Hewlett Packard Enterprise. AAG Slater is also overseeing antitrust lawsuits against Capital One, Apple, Google, and other major companies.* Finally, Wired reports the small Pacific island nation of Tuvalu is planning the first migration of an entire country. Tuvalu, which could be completely submerged by rising sea levels within the next 25 years, is seeking to resettle 280 Tuvaluans in Australia each year. This climate-driven mass migration is a stark sign of things to come if the international community continues to dither or deny the reality of the oncoming climate catastrophe. Today Tuvalu, tomorrow the world.This has been Francesco DeSantis, with In Case You Haven't Heard. Get full access to Ralph Nader Radio Hour at www.ralphnaderradiohour.com/subscribe