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I know 2026 feels like it ihas been here for months, but only a few weeks ago we were celebrating the nephrology accomplishments of 2025. The New Filtrate came together to review the year.The FiltrateJoel Topf @kidneyboy.bsky.social (COI)Swapnil Hiremath @hswapnil.medsky.social and on LinkedIn Editor in Chief of Kidney International Case ReportsAnna Gaddy (@AnnaGaddy) Winner of NephJC Rookie of the Year 2020Nayan Arora (@CaptainChloride.bsky.social)AC (@medpeedskidneys.bsky.social)Vipin Verghese (@vipvargh.bsky.social) co-winner of NephJC Engaged Scientist of the Year in 2021Brian Rifkin (@brianrifkin.bsky.social) Co-Editor in Chief NephJC. Winner of NephJC Rookie of the Year 2021Cristina Popa (@NephroSeeker) Co-Editor in Chief NephJC. Wwinner of NephJC Rookie of the Year 2022 and MVP 2023Editing and Show Notes byAnna Gaddy and Joel TopfThe Kidney Connection written and performed by Tim YauShow NotesTop Stories in Nephrology 2025 (NephJC)First Top sories in Nephrology 2010! (Renal Fellow Network)Links to all of the Top Stories in Nephrology, hosted on NephJC since 2017 (NephJC)1. IgA NephropathyVISIONARY: Sibeprenlimab in IgA Nephropathy — Interim Analysis of a Phase 3 Trial (NEJM)ORIGIN 3: A Phase 3 Trial of Atacicept in Patients with IgA Nephropathy (NEJM)APPLAUSE-IgA Alternative Complement Pathway Inhibition with Iptacopan in IgA Nephropathy (NEJM)Aliza M. Thompson, MD, MS (ASN) 2. Lupus NephritisREGENCY: Efficacy and Safety of Obinutuzumab in Active Lupus Nephritis (NEJM)3. Nobel prize winner and peripheral immune tolerance4. Xenotransplantation5. GLP1ra RevolutionRemodel REMODELing mechanistic trials for kidney disease: a multimodal, tissue-centered approach to understand the renal mechanism of action of semaglutide (Kidney International)SURPASS-CVOT Tirzepatide vs. Dulaglutide Is Associated with Reduced Major Kidney Events in Patients with Type 2 Diabetes, CVD, and Very High-Risk Kidney Diseases (Kidney Week abstract in JASN)Poll: 1 in 8 Adults Say They Are Currently Taking a GLP-1 Drug for Weight Loss, Diabetes or Another Condition, Even as Half Say the Drugs Are Difficult to Afford (KFF survey)6. GDMT implementation in CKD: lessons learnt from CONFIDENCE and MIRO-CKDConfidence Finerenone with Empagliflozin in Chronic Kidney Disease and Type 2 Diabetes (NEJM)MIRO-CKD Balcinrenone in combination with dapagliflozin compared with dapagliflozin alone in patients with chronic kidney disease and albuminuria: a randomised, active-controlled double-blind, phase 2b clinical trial (The Lancet)7. Flozin Meta analysisSMART-C. SGLT2 Inhibitors and Kidney Outcomes by Glomerular Filtration Rate and Albuminuria. A Meta-Analysis (JAMA)SMART-C. Effects of Sodium Glucose Cotransporter 2 Inhibitors by Diabetes Status and Level of Albuminuria. A Meta-Analysis (JAMA)8. Paradigm Shift: Aiming for CKD Remission9. Fish Oil and DialysisPISCES Fish-Oil Supplementation and Cardiovascular Events in Patients Receiving Hemodialysis (NEJM)10. Decline in Dialysis Patients in the United StatesUSRD 2025 Annual Data Report (USRDS)Tubular SecretionSwapnil Hiremath Alien Earth on FX Hulu (Wikipedia)AC A Christmas Carol by Charles Dickens (Wikipedia) and The Muppet Christmas Carol (Wikipedia)Anna Monty Don (Wikipedia)Nayan Back Street Boys at The Sphere (Wikipedia)Brian Marty Supreme (Wikipedia)Cristina The Yellow Tie (Wikipedia)Vipin Stranger Things, good for a four year old? (Wikipedia)Joel Crash Course: The Universe with Katie Mack and John Green (Apple PodCasts)
As Trump surges his Gestapo and threatens to annex new territory, his brain is collapsing. He's sundowning on Truth Social, nodding off in meetings, slurring words, slurping at the saliva pooling in his mouth. His insults and aggressions are as constant and predictable as his arms are, reaching out for handholds. Up until this point, discourse on the mental health of this decrepit fascist leader has used the kid gloves of psychology, psychoanalysis, and psychiatry, in which even the most informed analyses were constrained by the fact that experts were interpreting his inner states. For our part, we've compared his fate to that of charismatic cult leaders at the end of the line—and we'll do more of that today. Now a new posse of clinical commentators on IG and TikTok have made it all much more biological: we are witnessing, they say, the predictable signs of fast-progressing dementia. Show Notes Goldwater Rule vs Duty to Warn, American Academy of Psychiatry and Law World Health Organization: Dementia Signs and Symptoms of Dementia Alzheimer's disease: a comprehensive review of epidemiology, risk factors, symptoms diagnosis, management, caregiving, advanced treatments and associated challenges USC study finds new evidence linking dementia to problems with the brain's waste clearance system A new drug could stop Alzheimer's before memory loss begins A 2025 update on treatment strategies for the Alzheimer's disease spectrum Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission Broadening dementia risk models: building on the 2024 Lancet Commission report for a more inclusive global framework Study finds disparities in diagnosis and treatment of dementia Decomposing Racial and Ethnic Disparities in Risk and Protective Factors of Dementia in the U.S. Mapping racial and ethnic healthcare disparities for persons living with dementia: A scoping review Dementia Diagnosis Disparities by Race and Ethnicity Racial disparities in dementia determined by social factors Straight-forward Explainer: What's Going on With NIH Cuts to Alzheimer's Research? Learn more about your ad choices. Visit megaphone.fm/adchoices
Most medical encounters are structured as transactions. The patient comes in with a specific complaint, the medical expert identifies a discrete problem, and a specific intervention is prescribed.But at the heart of a medical encounter is a story. When a patient comes in with a medical problem, the problem cannot be disentangled from their life's narrative — doing so risks hollowing out the essence of what it means to care for another person. Our guest on this episode is award-winning author, and primary care physician Suzanne Koven, MD. Following the completion of her residency at Johns Hopkins Hospital, Dr. Koven joined the faculty at Harvard Medical School and practiced primary care medicine at Massachusetts General for 32 years. In 2019, she became the inaugural Writer in Residence at Mass General. Her writings have been published broadly—including in The Boston Globe, The New England Journal of Medicine, The Lancet, and The New Yorker. As a teacher and public speaker, she highlights the relationship between literature and medicine, and is a powerful advocate for female medical trainees. In this episode, Dr. Koven shares her journey to medicine at a time when few women were represented in the field and why she finds her undergraduate English classes to be more relevant to her clinical work than her science classes. We discuss narrative medicine, its value to patients and physicians alike, and how the modern healthcare system struggles to value the patient story. Finally, Dr. Koven leaves us with her advice for up-and-coming trainees: find a place in medicine where you can be yourself – for your own good and for your patients'.In this episode, you'll hear about: 3:00 - Dr. Koven's motivations for going into primary care medicine 15:49 - The impact that Dr. Koven's English degree has had on her approach to medicine 19:36 - What narrative medicine is 24:34 - What is lost when human connection and human story are deprioritized within the practice of medicine 31:15 - The benefits doctors experience when cultivating an appreciation for the arts37:21 - How gender representation in medicine has shaped Dr. Koven's experience as a physician42:54 - The need for the culture of medicine to adapt to changing demographics in the medical workforceIf you enjoyed this episode, please subscribe, rate, and review our show, available for free on Spotify, Apple Podcasts, or wherever you get your podcasts. If you know of a doctor, patient, or anyone working in health care who would love to explore meaning in medicine with us on the show, feel free to leave a suggestion in the comments or send an email to info@thedoctorsart.com.Copyright The Doctor's Art Podcast 2026
A large Lancet meta-analysis found no clinically meaningful association between prenatal acetaminophen exposure and autism, ADHD, or intellectual disability after restricting analyses to adjusted and sibling-comparison studies, with odds ratios essentially null; acetaminophen remains first-line for pain and fever in pregnancy. A Nordic BMJ case-control study of more than 17,000 gastric cancer cases found no increased risk of non-cardia adenocarcinoma with long-term proton pump inhibitor use after comprehensive confounder adjustment. Finally, a U.S. cohort study of older adults linked shingles vaccination to lower inflammation and slower biological aging across multiple systems, though causality cannot be confirmed due to observational design.
Welcome to the “Better Than Fine Podcast!”In this highly informative episode, host Darlene Marshall dives deep into the real story behind **ultra processed foods**, breaking down the latest research from top scientific journals—including a brand-new series from The Lancet. **What You'll Learn:** - The *four categories* of the NOVA food scale and why not all “processed” foods are created equal - How ultra processed foods drive **obesity**, heart disease, type 2 diabetes, cancer, and even depression - The shocking influence of *food industry lobbying and marketing*—and why your cravings might not be about “willpower” at all - Simple, actionable ways to cut ultra processed foods from your diet, support local farmers, and reclaim control over your health—even when access is limited **Why Listen/Watch?** If you care about your **well-being**, **mental health**, or want science-based answers to what's REALLY making our society sick, this episode is for you. [John Jewett](/speakers/A) doesn't just react to headlines—he reviews breakthrough studies, responds to common criticisms, and offers empowering solutions.
Ursodiol (ursodeoxycholic acid) is a prescription bile acid medication used to dissolve cholesterol gallstones, prevent gallstones during rapid weight loss, and treat liver diseases like primary biliary cholangitis (PBC) by reducing toxic bile acids and cholesterol production. It works by changing bile composition, making it less saturated with cholesterol, and is available as oral medication. Of course, it is also the foundational medication for treatment of diagnosed Intrahepatic Cholestasis of Pregnancy (ICP). Does this medication reduce adverse perinatal outcomes? In this episode, we will review a new study from the Green Journal, which will be out in February 2026, examining the recurrence risk for ICP using data from NY. In a patient with prior history of ICP, is there any guidance on monitoring of serum bile acids in the subsequent pregnancy before symptoms develop? We will explain. PLUS we will review the data on whether Ursodiol may hold promise in recurrence prevention or in reduction of adverse outcomes once the condition is diagnosed. Listen in for details. 1. 2019: Chappell LC, Bell JL, Smith A, Linsell L, Juszczak E, Dixon PH, Chambers J, Hunter R, Dorling J, Williamson C, Thornton JG; PITCHES study group. Ursodeoxycholic acid versus placebo in women with intrahepatic cholestasis of pregnancy (PITCHES): a randomised controlled trial. Lancet. 2019 Sep 7;394(10201):849-860. doi: 10.1016/S0140-6736(19)31270-X. Epub 2019 Aug 1. PMID: 31378395; PMCID: PMC6739598. https://pubmed.ncbi.nlm.nih.gov/31378395/2. February 08, 2025: Rahim, Mussarat N et al. Pregnancy and the liver. The Lancet. 2021; Volume 405, Issue 10477, 498 – 513 https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)02351-1/fulltext3. SMFM CS 53; 20214. Rosenberg, Henri M. MD; Sarker, Minhazur R. MD; Ramos, Gladys A. MD; Bianco, Angela MD; Ferrara, Lauren MD; DeBolt, Chelsea A. MD. Intrahepatic Cholestasis of Pregnancy Recurrence in a Subsequent Pregnancy. Obstetrics & Gynecology 147(2):p 239-241, February 2026. | DOI: 10.1097/AOG.0000000000006033 https://journals.lww.com/greenjournal/fulltext/2026/02000/intrahepatic_cholestasis_of_pregnancy_recurrence.13.aspx5. Ovadia C, Sajous J, Seed PT et al. Ursodeoxycholic acid in intrahepatic cholestasis of pregnancy: a systematic review and individual participant data meta-analysis. Lancet Gastroenterol Hepatol. 2021 Jul;6(7):547-558. doi: 10.1016/S2468-1253(21)00074-1. Epub 2021 Apr 27. PMID: 33915090; PMCID: PMC8192305.6. EASL Clinical Practice Guidelines on the management of liver diseases in pregnancy. European Association for the Study of the Liver; 2023
Chronic kidney disease (CKD) now affects about 788 million adults worldwide, more than double the number in 1990, making it one of the most widespread and underrecognized health threats A recent systematic analysis published in The Lancet revealed that CKD is now the ninth leading cause of death globally, responsible for roughly 1.48 million deaths in 2023 alone High blood sugar, elevated blood pressure, and excess body weight are the leading drivers of CKD worldwide, together accounting for most of the disease's overall health burden Early-stage CKD affects over 13% of the adult population globally, yet most cases remain undiagnosed because symptoms often don't appear until the disease is advanced You can lower your risk of CKD by keeping your blood pressure and blood sugar in check, getting regular movement, staying hydrated, reducing processed foods, and supporting kidney function with balanced nutrition
This week Jason Socrates Bardi joins in to talk about about the rivalry between three mathematicians that defined the fifty years surrounding World War I.About our guest:Jason Socrates Bardi is an award-winning journalist in DC who has written two books about the history of math: The Calculus Wars and The Fifth Postulate. He has published hundreds of articles about modern science and medicine in outlets including the San Francisco Chronicle, Good Morning America, US News & World Report, and The Lancet. He lives in Bethesda, Maryland.
El programa '¡Buenos días, Javi y Mar!' en CADENA 100 informa sobre la recomendación de Exteriores para que los españoles en Irán abandonen el país, ante las protestas con más de 2000 muertos reconocidos y cortes de internet. En Burgos, un error en la preparación de un medicamento causa la muerte de dos pacientes oncológicos y afecta a tres, con la Asociación del Defensor del Paciente pidiendo el cese del gerente. Adolescentes de Haro, La Rioja, manipulan fotos de compañeras con IA para crear contenido sexual, lo que lleva a una investigación escolar. Un estudio publicado en The Lancet revela que cinco minutos de ejercicio moderado diario reducen la mortalidad adulta en un 10%. Además, se discute sobre la huelga de médicos que exige un estatuto propio y la ayuda del Ministerio de Cultura de un millón de euros para salas de música en directo. El programa también destaca la historia de una mujer que da a luz en un cine, recibiendo su hija entradas gratis de por vida. Los oyentes ...
Referenced BlogsGlucose Spikes and CGMs: https://rawfoodmealplanner.com/why-low-carb-high-fat-diets-can-raise-blood-sugar GLP-1 Microdosing: https://rawfoodmealplanner.com/glp-1-microdosing-the-new-frontier-in-brain-health-inflammation-relief-and-metabolic-support-for-women CRISPR Technology for Cholesterol: https://rawfoodmealplanner.com/can-gene-editing-cure-high-cholesterol-or-are-we-skipping-the-root-cause Boost Your Wellness Journey:The Brain Reboot Plan: 5 Simple Daily Shifts for More Focus, Energy & Peacehttps://rawfoodmealplanner.com/brain-reboot-plan/Revitalize Your Brain: A Lifestyle Approach for Women Over 50https://rawfoodmealplanner.clickfunnels.com/webinar-replay-brain-health-breakthrough-coaching-programRESET: 3 Metabolic Mistakes Women 30+ Make And How to Fix Themhttps://rawfoodmealplanner.com/reset-3-metabolic-mistakes-women-30-make-and-how-to-fix-them/The Lancet published a study here https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(24)00191-0/fulltext emphasizing that young adults (ages 18–39) are a neglected but crucial window for dementia prevention. Most dementia research focuses on mid-to-late life, yet many modifiable risk factors that affect long-term brain health emerge or peak in young adulthood.Key Modifiable Risk FactorsEducation: Low levels reduce cognitive reserve and increase dementia risk.Hearing loss: One billion young adults globally are at risk due to unsafe listening practices.Traumatic brain injury (TBI): High rates from sports, motor accidents, and intimate partner violence.Hypertension: One in 12 young adults is affected; rates higher among Black Americans and in LMICs.Alcohol use: Peaks in early 20s, linked to long-term brain changes.Obesity & physical inactivity: Both rising rapidly; linked to inflammation and cardiovascular risk.Smoking/vaping: 90% of daily smokers start before 26.Depression & social isolation: Peak in early 20s, linked to later ADRD (Alzheimer's disease and related dementias) risk.Diabetes: 4% prevalence in young adults; prediabetes affects 1 in 4.Environmental factors: Air pollution, vision loss, high LDL cholesterol, and even emerging risks like sleep disruption, stress, spirituality, and microplastics.Join the Conversation:Subscribe and share this episode with anyone on their own path of health and transformation. // HOST Samantha Salmon, NBC-HWC Nationally Board Certified Health & Wellness Coach Brain Health Licensed Trainer | Integrative Nutrition Coach | Intuitive Nutrition Coach for Brain & Metabolic HealthThe information provided in this broadcast is for educational purposes only and is not intended as medical advice. These statements have not been evaluated by the Food and Drug Administration or the equivalent in your country. Any products/services mentioned are not intended to diagnose, treat, cure, or prevent disease. RawFoodMealPlanner.com © 2026
在腦神經的複雜對話中,囊泡單胺轉運體(vesicular monoamine transport,簡稱 VMAT)扮演著極為關鍵的角色。它負責把多巴胺、血清素、正腎上腺素等神經傳導物質「打包」進小囊泡,讓神經元在需要時能一次釋放出精準劑量,傳遞給下一個神經細胞。若沒有這道工序,腦內訊號就像缺乏秩序的雜音,難以維持正常的動作、情緒與認知。正因如此,VMAT 不只是一個小小的運輸蛋白,而是維持神經網路穩定運作的樞紐。如何調控 VMAT 成為新藥研發的重要戰場。若能減少小泡中可釋放的多巴胺與血清素,就有機會抑制因訊號過強而導致的病症,例如亨丁頓舞蹈症( Huntington's disease)或遲發性不自主運動(tardive dyskinesia)。 這便是 VMAT 抑制劑的立足點:它們不是直接封鎖受體,而是從源頭減少囊泡裡的「存貨」。近十年來,藥廠競逐的焦點已經不只是找到能抑制 VMAT2 的分子,更在於如何讓藥物具有更高的選擇性、更少的脫靶作用,以及更穩定的藥物動力學特性。權威醫學期刊《柳葉刀》(Lancet)的這篇回顧文獻,就是完整地介紹囊泡單胺轉運體抑制劑,這項藥物研發的新焦點。 -
Kyle welcomes Dr. Andrew Wakefield, a controversial figure known for his claims linking the MMR vaccine to autism. Wakefield shares his journey from a traditional medical background to becoming a prominent critic of vaccines. The podcast covers the initial study published in The Lancet, its subsequent backlash, and Wakefield's journey through public and professional challenges. Wakefield discusses his transition to filmmaking as a means to spread his message, highlighting his documentary 'Vaxxed' and other key works. The conversation delves into the impact of vaccines on public health, the introduction and potential risks of mRNA vaccines, and broader issues surrounding vaccine policies and public trust. Highlighted are the testimonies of parents with vaccine-injured children, the legal and scientific battles against the mainstream medical community, and the importance of public awareness. The podcast also explores alternative treatments for vaccine-related injuries, emphasizing gut health and the potential benefits of cannabinoids. Dr. Wakefield expresses hope for more informed public health policies and discusses his plans for future projects, including a film addressing the long-term impacts on children left behind by vaccination policies. Connect with Andy here: Website - Wakefield Media Group Instagram From Kyle: The Community is coming! Click here to learn more Full Temple Reset is back with Erick Godsey, Click here to learn more Our Sponsors: Let's level up your nicotine routine with Lucy. Go to Lucy.co/KKP and use promo code (KKP) to get 20% off your first order. Lucy offers FREE SHIPPING and has a 30-day refund policy if you change your mind. These are the b3 bands I was talking about. They are amazing, I highly recommend incorporating them into your movement practice. Go to tonum.com/KKP, use the code KKP, and get 10% off your first order of Nouro. Connect with Kyle: I'm back on Instagram, come say hey @kylekingsbu Twitter: @kingsbu Our Farm Initiative: @gardenersofeden.earth Odysee: odysee.com/@KyleKingsburypod Youtube: https://www.youtube.com/@Kyle-Kingsbury Kyle's Website: www.kingsbu.com - Gardeners of Eden site If you enjoyed this podcast, please subscribe & leave a 5-star review with your thoughts!
Big Food now supplies over half of U.S. adults' at-home calories through ultraprocessed foods and, according to a study in The Lancet, these foods are now a major global health threat driving chronic disease The NOVA food classification groups foods by processing. Group 4 (ultraprocessed products) are industrial formulations that displace healthy diets and seriously harm health Across 104 studies, higher ultraprocessed food intake was consistently linked to poorer metabolic health, faster weight gain, diabetes, cardiovascular disease, cancer, and long-term exposure to harmful additives and endocrine-disrupting chemicals Most governments rely on weak, nutrient-focused policies and voluntary programs, while industry interference and trade challenges block stronger rules that reduce availability, marketing, and additives in ultraprocessed foods Transnational food giants shape laws, research, and public opinion to protect profits, so personal control starts with awareness, cleaning your pantry, smarter swaps, limiting vegetable oils, and strong social support
I am thrilled to have Dr. Ken Berry joining me on the podcast for the third time today. He was with me before on episodes 111 and 139. Dr. Berry is a physician, best-selling author, and passionate health advocate with a no-nonsense approach to health and wellness. He has been practicing at the Berry Clinics since 2003 and is an active community member. He has written two books, Lies My Doctor Told Me and the recently published Kicking Ass After Fifty, in addition to various other resources, including Common Sense Labs Today. He also has a YouTube channel, serving over 2 million subscribers- one of my favorite go-to resources for my patients. In our conversation today, we dive into the latest Lancet research on the impact of a diabetes diagnosis on life expectancy, along with insights from the American Diabetes Association regarding the costs of diabetes care. We discuss the need for proper diagnostic modalities to identify insulin resistance earlier and the labs Dr. Berry uses in his practice for identifying those at risk. We explore the recently recognized American Heart Association syndrome, CKM (Cardiovascular Kidney Metabolic Syndrome), and the role of GLP agonists, continuous glucose monitors, and glucometers. Dr. Berry also shares his views on plant-based diets, proper diets, and more. IN THIS EPISODE YOU WILL LEARN: Why does metabolic health continue to deteriorate in most of the general population? The staggering amount of disposable plastic used within the healthcare industry The importance of fasting insulin levels when diagnosing metabolic disease Why are blood tests essential for determining metabolic health? The benefits of glucometers and continuous glucose monitors for metabolic health How Dr. Berry's health improved after following a specific diet and measuring his lab results for a month How misinformation gets spread within the health and wellness industry Why are doctors not informing their patients about the absence of long-term studies and deluding them with false information? The long-term effects of Semaglutide on the body How a proper diet can naturally lower lipid levels The limitations of the germ model for treating chronic diseases Connect with Cynthia Thurlow Follow on X, Instagram & LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community (The Midlife Pause/Cynthia Thurlow) Cynthia's Menopause Gut Book is on presale now! Cynthia's Intermittent Fasting Transformation Book The Midlife Pause supplement line Connect with Dr. Ken Berry On YouTube Instagram, Facebook Twitter Dr. Berry's books Lies My Doctor Told Me Kicking Ass After 50 Common Sense Labs Dr. Berry's Private Community Phdhealth.community Medical News article Mentioned Here's What to Know About Cardiovascular-Kidney-Metabolic Syndrome, Newly Defined by the AHA Previous Episodes Featuring Dr. Ken Berry Ep. 111 – Is The Keto Diet The Proper Human Diet? – with Dr. Ken Berry Ep. 139 – Hyperinsulinemia: What You Should Know About This National Health Crisis with Dr. Ken Berry
Dry January often raises big questions: how much alcohol is actually safe, and do you need to stop drinking altogether to protect your health? In this episode, world-leading alcohol expert Professor David Nutt explains why alcohol ranks as one of the most harmful drugs to society, how even “normal” drinking can affect your health, and what the science really says about cutting back without giving it up completely. David, a neuropsychopharmacologist and former UK government drug adviser, explains why alcohol was ranked the most harmful drug overall in a landmark comparison of 20 drugs, how harm rises sharply as drinking increases, and unpacks common beliefs like red wine being “good for you”. The conversation also covers the social benefits of alcohol and why the goal isn't necessarily to stop drinking, but to drink with awareness. If you drink at all - whether it's a glass most nights or more on weekends - this episode helps you understand where the real risks begin, and how to make alcohol work for you, not against you. And for listeners using dry January as a reset, David shares practical, science-based advice on how to cut down safely and sustainably. If you're pausing and reflecting this dry January, what might change when you start drinking again? And which habits are worth leaving behind for good? Unwrap the truth about your food
Currently, as of today's date, neither the ACOG nor SMFM currently support routine early induction of labor for suspected fetal macrosomia, instead recommending individualized counseling and reserving elective cesarean for extreme estimated fetal weights. However, a 2025 multicenter, open-label, randomized controlled trial was published in the Lancet comparing induction of labor versus standard care in pregnant women with fetuses suspected to be large for gestational age. The study used a parallel-group design with 1:1 randomization, enrolling women from 106 NHS hospitals across England, Scotland, and Wales. The per-protocol analysis demonstrated a significant reduction (40%) in shoulder dystocia with induction of labor at 38- 38 weeks and 4 days. Is this in conflict with the ACOG current guidance? In this episode, we will review the “Big Baby study” from the Lancet and provide 3 main limitations of this very large study, review the importance of PP vs ITT results, and explain why more data is still needed. Listen in for details. 1. ACOG PB 178; 2017 (reaffirmed 2024)2. Gardosi J, Ewington LJ, Booth K, Bick D, Bouliotis G, Butler E, Deshpande S, Ellson H, Fisher J, Gornall A, Lall R, Mistry H, Naghdi S, Petrou S, Slowther AM, Wood S, Underwood M, Quenby S. Induction of labour versus standard care to prevent shoulder dystocia in fetuses suspected to be large for gestational age in the UK (the Big Baby trial): a multicentre, open-label, randomised controlled trial. Lancet. 2025 May 17;405(10491):1743-1756. doi: 10.1016/S0140-6736(25)00162-X. Epub 2025 May 1. PMID: 40319899.3. Blaauwgeers, Anne N et al. Rethinking induction of labour for LGA fetuses: the Big Baby trial. The Lancet, Volume 406, Issue 10512, 1562
In mid-December 2025, the FDA approved an at home devicethat aims to treat depression by sending electric current into a part of the brain (the prefrontal cortex) known to regulate mood. This has been available in the UK since 2019 but it is new to the US. The manufacturer has stated that over 55,000 patients have used the device across Europe, the UK, Switzerland, and Hong Kong. How does this work? Is there data to support this new therapy? In this episode, we will summarize three consecutive years of data (2023, 2024,2025) to answer that question. Listen in for details. 1. Sci Amer: https://www.scientificamerican.com/article/u-s-approves-first-device-to-treat-depression-with-brain-stimulation-at-home/2. August 12, 2023: Burkhardt, Gerrit et al.Transcranial direct current stimulation as an additional treatment to selectiveserotonin reuptake inhibitors in adults with major depressive disorder inGermany (DepressionDC): a triple-blind, randomised, sham-controlled,multicentre trial The Lancet, Volume 402, Issue 10401, 545 – 5543. October 21, 2024: Woodham, R.D., Selvaraj, S.,Lajmi, N. et al. Home-based transcranial direct current stimulation treatmentfor major depressive disorder: a fully remote phase 2 randomizedsham-controlled trial. Nat Med 31, 87–95 (2025). https://doi.org/10.1038/s41591-024-4. December 15, 2025: Moshfeghinia R, Bordbar S,Roointanpour Y, Arab Bafrani M, Shalbafan M. Efficacy and safety of home-basedtranscranial direct current stimulation (tDCS) on patients with depressivedisorders: a systematic review and meta-analysis of randomized clinical trials.Sci Rep. 2025 Dec 15;15(1):43850. doi: 10.1038/s41598-025-28648-5. PMID:41398008; PMCID: PMC12705823.
Peripheral artery disease has been called the ‘silent circulatory crisis'—affecting millions, limiting mobility, and quietly raising the risk of heart attack, stroke, and limb loss. For decades, treatment focused on walking programs, aspirin, and sometimes a stent or bypass. But today, the landscape is changing. From PCSK9 inhibitors that drive cholesterol to record lows, to GLP-1 agonists like semaglutide improving walking distance, to novel antithrombotic strategies that balance bleeding and clotting—PAD care is entering a new era. In this episode, we'll explore the breakthroughs, the evidence behind them, and what they mean for patients who just want to keep moving forward." Hosted by the University of Michigan Department of Vascular Surgery: - Robert Beaulieu, Program Director - Frank Davis, Assistant Professor of Surgery - Luciano Delbono, PGY-5 House Officer - Andrew Huang, PGY-4 House Officer - Carolyn Judge, PGY-2 House Officer Learning objectives: 1. Describe the current evidence-based recommendations for multifactorial medical management of peripheral artery disease (PAD), including lipid, glycemic, and antithrombotic strategies per 2024 SVS/AHA guidelines. 2. Interpret the clinical implications of the FOURIER trial regarding the role of PCSK9 inhibition in reducing cardiovascular events in patients with atherosclerotic disease, including PAD. 3. Evaluate the emerging role of GLP-1 receptor agonists, such as semaglutide, in improving walking performance and quality of life among patients with diabetic PAD based on findings from the STRIDE trial. Sponsor URL: https://www.goremedical.com/ References: H. L. Gornik et al., “2024 ACC/AHA/AACVPR/APMA/ABC/SCAI/SVM/SVN/SVS/SIR/VESS Guideline for the Management of Lower Extremity Peripheral Artery Disease,” JACC, vol. 83, no. 24, pp. 2497–2604, June 2024, doi: 10.1016/j.jacc.2024.02.013. L. Mazzolai et al., “2024 ESC Guidelines for the management of peripheral arterial and aortic diseases: Developed by the task force on the management of peripheral arterial and aortic diseases of the European Society of Cardiology (ESC) Endorsed by the European Association for Cardio-Thoracic Surgery (EACTS), the European Reference Network on Rare Multisystemic Vascular Diseases (VASCERN), and the European Society of Vascular Medicine (ESVM),” Eur Heart J, vol. 45, no. 36, pp. 3538–3700, Sept. 2024, doi: 10.1093/eurheartj/ehae179. https://pubmed.ncbi.nlm.nih.gov/40169145/ M. S. Sabatine et al., “Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease,” N Engl J Med, vol. 376, no. 18, pp. 1713–1722, May 2017, doi: 10.1056/NEJMoa1615664. https://pubmed.ncbi.nlm.nih.gov/28304224/ M. P. Bonaca et al., “Semaglutide and walking capacity in people with symptomatic peripheral artery disease and type 2 diabetes (STRIDE): a phase 3b, double-blind, randomised, placebo-controlled trial,” Lancet, vol. 405, no. 10489, pp. 1580–1593, May 2025, doi: 10.1016/S0140-6736(25)00509-4. https://pubmed.ncbi.nlm.nih.gov/40169145/ N. E. Hubbard, D. Lim, and K. L. Erickson, “Beef tallow increases the potency of conjugated linoleic acid in the reduction of mouse mammary tumor metastasis,” J Nutr, vol. 136, no. 1, pp. 88–93, Jan. 2006, doi: 10.1093/jn/136.1.88. https://pubmed.ncbi.nlm.nih.gov/16365064/ Please visit https://behindtheknife.org to access other high-yield surgical education podcasts, videos and more. If you liked this episode, check out our recent episodes here: https://behindtheknife.org/listen Behind the Knife Premium: General Surgery Oral Board Review Course: https://behindtheknife.org/premium/general-surgery-oral-board-review Trauma Surgery Video Atlas: https://behindtheknife.org/premium/trauma-surgery-video-atlas Dominate Surgery: A High-Yield Guide to Your Surgery Clerkship: https://behindtheknife.org/premium/dominate-surgery-a-high-yield-guide-to-your-surgery-clerkship Dominate Surgery for APPs: A High-Yield Guide to Your Surgery Rotation: https://behindtheknife.org/premium/dominate-surgery-for-apps-a-high-yield-guide-to-your-surgery-rotation Vascular Surgery Oral Board Review Course: https://behindtheknife.org/premium/vascular-surgery-oral-board-audio-review Colorectal Surgery Oral Board Review Course: https://behindtheknife.org/premium/colorectal-surgery-oral-board-audio-review Surgical Oncology Oral Board Review Course: https://behindtheknife.org/premium/surgical-oncology-oral-board-audio-review Cardiothoracic Oral Board Review Course: https://behindtheknife.org/premium/cardiothoracic-surgery-oral-board-audio-review Download our App: Apple App Store: https://apps.apple.com/us/app/behind-the-knife/id1672420049 Android/Google Play: https://play.google.com/store/apps/details?id=com.btk.app&hl=en_US
Boost Your Wellness Journey:The Brain Reboot Plan: 5 Simple Daily Shifts for More Focus, Energy & Peacehttps://rawfoodmealplanner.com/brain-reboot-plan/Revitalize Your Brain: A Lifestyle Approach for Women Over 50https://rawfoodmealplanner.clickfunnels.com/webinar-replay-brain-health-breakthrough-coaching-programRESET: 3 Metabolic Mistakes Women 30+ Make And How to Fix Themhttps://rawfoodmealplanner.com/reset-3-metabolic-mistakes-women-30-make-and-how-to-fix-them/The Lancet published a study here https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(24)00191-0/fulltext emphasizing that young adults (ages 18–39) are a neglected but crucial window for dementia prevention. Most dementia research focuses on mid-to-late life, yet many modifiable risk factors that affect long-term brain health emerge or peak in young adulthood.Key Modifiable Risk FactorsEducation: Low levels reduce cognitive reserve and increase dementia risk.Hearing loss: One billion young adults globally are at risk due to unsafe listening practices.Traumatic brain injury (TBI): High rates from sports, motor accidents, and intimate partner violence.Hypertension: One in 12 young adults is affected; rates higher among Black Americans and in LMICs.Alcohol use: Peaks in early 20s, linked to long-term brain changes.Obesity & physical inactivity: Both rising rapidly; linked to inflammation and cardiovascular risk.Smoking/vaping: 90% of daily smokers start before 26.Depression & social isolation: Peak in early 20s, linked to later ADRD (Alzheimer's disease and related dementias) risk.Diabetes: 4% prevalence in young adults; prediabetes affects 1 in 4.Environmental factors: Air pollution, vision loss, high LDL cholesterol, and even emerging risks like sleep disruption, stress, spirituality, and microplastics.Join the Conversation:Subscribe and share this episode with anyone on their own path of health and transformation. // HOST Samantha Salmon, NBC-HWC Nationally Board Certified Health & Wellness Coach Brain Health Licensed Trainer | Integrative Nutrition Coach | Intuitive Nutrition Coach for Brain & Metabolic HealthThe information provided in this broadcast is for educational purposes only and is not intended as medical advice. These statements have not been evaluated by the Food and Drug Administration or the equivalent in your country. Any products/services mentioned are not intended to diagnose, treat, cure, or prevent disease. RawFoodMealPlanner.com © 2025
In 2025, Creating Dementia Solutions is looking deeper into what The Lancet Commission on dementia prevention, intervention and care has indicated are ways people can reduce their risk of dementia.Miles for Memories Founder Sherii Sherban talks about some of the wide-ranging topics covered from the Lancet List in 2025 and looks ahead to 2026 at some of the programs they'll offer for those battling dementia and their caregivers. Episode ResourcesThe Lancet Commission Risk Factors for DementiaMiles for Memories websiteMiles for Memories technologySherii Sherban talks to Community Matters about MFM technologyMore Creating Dementia Solutions episodesABOUT MILES FOR MEMORIESMiles For Memories is a Calhoun County, Michigan organization created in 2013 to raise awareness and funds for Alzheimer's Disease. Later in 2014, the vision was expanded to include all types of dementia. MFM raises money each year through sponsorships, community events, and grants to gather funds to create local programming for both the person living with dementia and the caregiver. Along with local efforts, 20% of the funds to prevention-related dementia research. Miles for Memories is a committee of 70-plus volunteers and are always looking for more to get involved.
我們都知道運動對身體健康有益,但你是否知道,運動更是對抗大腦老化與認知退化的強大武器? 2025年發表於 The Lancet 的權威綜論研究指出,規律身體活動可以從大腦結構、功能到分子層面,多方位守護我們的腦部健康,延緩認知能力下降,甚至降低阿茲海默症等神經退化性疾病的風險。 運動對於大腦的神經保護作用主要體現在以下幾個層面:
Oggi affrontiamo un tema enorme: la cosiddetta “sensibilità al glutine” non celiaca. Una revisione pubblicata su The Lancet ha analizzato la la “non-celiac gluten sensitivity” — condizione che molte persone attribuiscono al glutine pur non avendo celiachia. Sintomi? Gonfiore, dolore addominale, stanchezza, fastidi diffusi. Ma quando i ricercatori hanno confrontato reazioni in studi controllati, solo una piccola quota mostrava risposte specifiche al glutine.
For op mod hver tredje, der får PTSD, bliver traumet en kronisk følgesvend. Og PTSD har vist sig at være en af de psykiske lidelser, der er svær at behandle. Nu har danske forskere fået penge til at undersøge, om stoffet MDMA - også kendt som ecstasy - kan bruges til at behandle PTSD. Resultaterne fra udlandet er lovende, men rejser også vigtige spørgsmål: Hvordan kan et psykedelisk stof som MDMA hjælpe mod PTSD? Hvordan virker det i hjernen? Kan man virkelig løsne op for sine traumer med et psykedelisk trip? Og er det sikkert…? I den her episode taler vi med en af forskerne bag forsøget for at blive klogere på netop det! Medvirkende: Sidsel Karsberg, lektor, Psykologisk Institut - Center for Rusmiddelforskning, Aarhus Universitet Redaktion: Anne Sophie Thingsted, Nana Elving Hansen, Eva Berg Søndergaard, Christoffer Bjerre og Benjamin D'Souza Sidsel Karsberg og hendes kollegers forsøg med MDMA-terapi mod PTSD: ‘RCT and Mixed-Methods Evaluation of Psychotherapy vs. Music-Assisted Relaxation in MDMA-Facilitated Treatment of Service-Related PTSD' Målgruppen er veteraner, politi, ambulancereddere og øvrigt beredskab, hvis traumereaktioner gerne skal være opstået inden for de sidste ti år. Er du i målgruppen og interesseret i at deltage i forsøget, kan du finde mere info her: https://redcap.rn.dk/surveys/?s=89M49EALYWAF7CJ7 Relevante studier: Overbliksstudie om de lovende effekter af forsøg i bl.a. USA Sammenhængen mellem MDMA og oxytocin, som forskere peger på, kan have en positiv effekt i forhold til terapien Flere studier om PTSD og MDMA: Første studie med kontrolgruppe fra 2010, som pegede på, at MDMA kunne hjælpe mod behandlingsresistent PTSD Studie fra samme forskningsgruppe om langtidseffekten af MDMA mod PTSD Studie fra The Lancet fra 2018, der peger på en positiv effekt hos krigsveteraner, brandmænd og politibetjente med PTSD Videnskab.dk-artikler: MDMA-terapi mod PTSD i Danmark: Forskere får knap 6 millioner kroner til stort forsøg MDMA: Hvad er det? Hvad gør det? Hjerneforsker: 2024 kan blive året, hvor MDMA bliver godkendt til terapi-behandling Tilbageslag for MDMA-terapi: Styrelse dumper ansøgning om godkendelse i USA Brainstorm er støttet af Lundbeckfonden.
“Too far, too fast?”In this sixth episode, Sarah Harrison, Director of the MHPSS Hub, and Dan Amias, Senior Innovation Learning Adviser at Elrha, speaks with Mercy Githara, MHPSS Manager at the Kenya Red Cross Society, and Anne de Graaf, Technical Officer at the World Health Organization (WHO) about two chatbots: STARS, a non-AI chatbot developed by WHO, and Chat Care, an AI chatbot being deployed in Kenya by the Red Cross.Key resources for practitioners:Kenya Red Cross Society: Chat Care, AI Powered Mental Health Chatbot WHO: Doing What Matters in Times of Stress evidence based self-help guide WHO: STARS chatbot for more information contact psych_interventions@who.int Red Cross Digital MHPSS pledge: Leveraging and facilitating technology-empowered pathways MHPSS Hub resources on Suicide prevention:Find infographics, videos, podcasts, guides and tools on suicide prevention Read more about the research:STARS chatbot (non-AI): de Graaff A.M, et al. Evaluation of a Guided Chatbot Intervention for Young People in Jordan: Feasibility Randomized Controlled Trial JMIR Ment Health Keyan, D., et al. The development of a World Health Organization transdiagnostic chatbot intervention for distressed adolescents and young adults. Akhtar, A., et al. Scalable Technology for Adolescents and Youth to Reduce Stress in the Treatment of Common Mental Disorders in Jordan: Protocol for a Randomized Controlled Trial. Karim Chatbot: Madianou, M. Nonhuman humanitarianism: when “AI for good” can be harmful. Information, Communication & SocietyTorous, J. et al. Assessing generative artificial intelligence for mental health, The Lancet.Spencer SW, Masboungi C. Enabling access or automating empathy? Using chatbots to support GBV survivors in conflicts and humanitarian emergencies, International Review of the Red Cross. Developing digital MHPSS resources:Reach out to the MHPSS Hub: mhpsshub@rodekors.dk or Elrha: info@elrha.org for collaboration on developing digital MHPSS approaches.Evidence from the Frontline: Mental Health in Crisis-Affected Contexts is a six-episode mini-series produced in collaboration between the MHPSS Hub and Elrha, designed for practitioners working in humanitarian and crisis contexts, the series highlights impactful interventions and practical insights from experts in the field.
Send us a textFighting climate change can feel like a hopeless battle. Who can take on the giant fossil fuel companies when governments are not even bothering? How can countries act when every day temperatures rise, superstorms flood coastal areas, droughts devastate crops, and weather patterns bring insects and new diseases to areas previously spared?But there is something powerful and important that each and every resident of this planet can do to improve the health of the planet and at the same time improve their own health: eat better.A new report from the EAT-Lancet Commission lays out just how to do it and it details the benefits of what it calls the Planetary Health Diet. The current way people produce food contributes 30 percent of greenhouse gas emissions that are driving the warming of the Earth's atmosphere, the report notes – and that in turn is causing the increasing disruption of weather systems. Even if the entire world stopped using fossil fuels tomorrow, if people keep producing food the way they do now, global warming would continue.But a change in the way people eat can help stop it, and according to the commission, it would not be difficult or unpleasant.The mostly plant-based diet the experts recommend would not be a radical departure from how many people around the world eat now and it is based on what research shows would reduce rates of the biggest killers of people in most high-income countries and increasingly in low- and middle-income countries – heart disease, cancer, and diabetes. It would mean eating mostly whole grains; fruits; vegetables; legumes, such as beans; tubers, such as sweet potatoes; and cutting out added fats and sugars. People could still eat some meat and dairy if they wanted to, but variety should replace ultra-processed foods.This change in diet would drive a change in agriculture that would slow the destruction of forests that in turn could reduce pollution from burning and return biodiversity that nurtures a healthier environment, the report says. And moving away from intensive livestock farming could help stop the conditions that have fueled the rise of antimicrobial resistance – so-called drug-resistant superbugs – that evolve when farmers feed antibiotics to their animals.In this episode, Dr. Patrick Webb, Professor of Food and Nutrition Economics, Policy, and Programs at Tufts University in Boston and an EAT-Lancet Commissioner, explains some of the ideas behind the report and why food is medicine, both for humanity and for the planet.
Send us a message with this link, we would love to hear from you. Standard message rates may apply. In this episode of Your Checkup, we break down lipoprotein(a) — a largely inherited form of cholesterol that can significantly increase the risk of heart disease and stroke, even when standard cholesterol numbers look normal. We talk about what Lp(a) is, why it matters, who should be tested, and how it helps explain “unexpected” heart events in otherwise healthy people. While Lp(a) can't currently be lowered with diet or exercise, knowing your level allows you and your care team to be more intentional about prevention by aggressively managing other risk factors like LDL cholesterol, blood pressure, and diabetes. We also discuss what the numbers mean, why most people only need to be tested once, and the promising treatments currently being studied that may change care in the future. References (for Show Notes)Nordestgaard BG, Langsted A. Lipoprotein(a) and Cardiovascular Disease. Lancet. 2024;404(10459):1255-1264.Reyes-Soffer G, et al. AHA Scientific Statement on Lipoprotein(a). Arterioscler Thromb Vasc Biol. 2022;42(1):e48-e60.Di Fusco SA, et al. Lipoprotein(a): Risk Factor and Emerging Target. Heart. 2022;109(1):18-25.Nasrallah N, et al. Lp(a) in Clinical Practice. Eur J Clin Invest. 2025:e70127.Greco A, et al. Lipoprotein(a) as a Pharmacological Target. Circulation. 2025;151(6):400-415.Bess C, Mehta A, Joshi PH. All We Need to Know About Lipoprotein(a). Prog Cardiovasc Dis. 2024;84:27-33.Support the showSubscribe to Our Newsletter! Production and Content: Edward Delesky, MD & Nicole Aruffo, RNArtwork: Olivia Pawlowski
You've read about how this groundbreaking trial on ketamine vs etomidate for RSI "Changes Everything!" on the socials. Or perhaps "it's horribly biased and unnecessary... we're already knew all this!". Why? Well.. social media. Listen in as Dr Jarvis discusses not just this trial, but what the evidence landscape was before it was released. Why was it done, how was it done, what does it show, and how can we integrate it into our practice?Citations:1. Casey JD, Seitz KP, Driver BE, et al. Ketamine or Etomidate for Tracheal Intubation of Critically Ill Adults. N Engl J Med. Published online December 9, 2025.2. Jabre P, Combes X, Lapostolle F, et al. Etomidate versus ketamine for rapid sequence intubation in acutely ill patients: a multicentre randomised controlled trial. Lancet. 2009;374(9686):293-300. 3. Matchett G, Gasanova I, Riccio CA, et al. Etomidate versus ketamine for emergency endotracheal intubation: a randomized clinical trial. Intensive Care Med. 2022;48(1):78-91. 4. Koroki T, Kotani Y, Yaguchi T, et al. Ketamine versus etomidate as an induction agent for tracheal intubation in critically ill adults: a Bayesian meta-analysis. Crit Care. 2024;28(1):48. 5. Yeh RW, Valsdottir LR, Yeh MW, et al. Parachute use to prevent death and major trauma when jumping from aircraft: randomized controlled trial. BMJ. 2018;363:k5094. doi:10.1136/bmj.k5094
Research from The Lancet found that only about 16% to 30% of self-identified gluten-sensitive individuals experience symptoms triggered by gluten alone Many people who believe they're gluten sensitive are actually reacting to fermentable carbohydrates (FODMAPs) or gut-brain hypersensitivity, not gluten itself Natural FODMAPs from whole foods like fruit and grass fed dairy help feed beneficial gut bacteria such as Akkermansia muciniphila, which strengthens your gut lining and supports immunity Eliminating seed oils rich in linoleic acid and eating about 250 grams of healthy carbohydrates daily restores mitochondrial energy, improves digestion, and rebuilds a resilient gut Once your gut is healed, gradually reintroducing whole grains helps expand your diet and restore comfort, turning food from a source of fear into a foundation for long-term health
Podcast Family, we have covered PCOS on this show many times in the past; and yet- again, there is new information! A new publication from AJOG (Gray journal) describes a new meta-analysis on preconception/continued metformin use in the first trimester. Is this helpful? How does this contrast with the 2023 international guidance update on PCOS? Listen in for details. 1. ASRM: Recommendations from the 2023 International Evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome (2023)2. Cheshire J, Garg A, Smith P, Devall AJ, Coomarasamy A, Dhillon-Smith RK. Preconception and first-trimester metformin on pregnancy outcomes in women with polycystic ovary syndrome: a systematic review and meta-analysis. Am J Obstet Gynecol. 2025 Dec;233(6):530-547.e8. doi: 10.1016/j.ajog.2025.05.038. Epub 2025 Jun 3. PMID: 40473092.3. Løvvik TS, Carlsen SM, Salvesen Ø, et al. Use of Metformin to Treat Pregnant Women With Polycystic Ovary Syndrome (PregMet2): A Randomised, Double-Blind, Placebo-Controlled Trial. The Lancet. Diabetes & Endocrinology. 2019;7(4):256-266. doi:10.1016/S2213-8587(19)30002-6.4. Teede HJ, Tay CT, Laven J, et al. Recommendations From the 2023 International Evidence-Based Guideline for the Assessment and Management of Polycystic Ovary Syndrome. Fertility and Sterility. 2023;120(4):767-793. doi:10.1016/j.fertnstert.2023.07.025.
What happens when the brain flatlines - yet consciousness continues?In this episode of Mind-Body Solution, Dr Tevin Naidu speaks with world-renowned cardiologist and pioneering near-death experience (NDE) researcher Dr Pim van Lommel. His groundbreaking Lancet study remains one of the most rigorously documented clinical investigations into NDEs - and its implications challenge our deepest assumptions about the mind, the brain, and the nature of reality.We explore:• The medical evidence for consciousness during cardiac arrest• Why the brain cannot account for NDEs• The transceiver/filter model of consciousness• Out-of-body perceptions verified during resuscitation• Why materialism may be scientifically untenable• The long-term personality transformation following NDEs• Implications for neuroscience, medicine, ethics, and the mind-body problem• What dying actually feels like• Why Pim now views death as “a transition, not an end”This is one of the most comprehensive, medically grounded explorations of non-local consciousness available today. Whether you're a skeptic, scientist, philosopher, or simply curious, this conversation forces a radical re-examination of what consciousness is.TIMESTAMPS:(00:00) – Introduction(01:00) – Consciousness & Near Death Experiences (NDEs)(05:06) – Findings from the landmark 2001 Lancet study(09:10) – Out-of-body experiences (OBEs) & verified accounts(10:42) – Consciousness beyond the brain: receiver model(19:25) – Memory, identity & self without the body(20:25) – Universal NDE elements & what they imply(29:08) – Critics, skeptics & scientific resistance(31:23) – Why consciousness cannot be measured(32:46) – Monism? Dual-aspect? Idealism? Pim's stance(35:56) – Implications for medical ethics & end-of-life care(37:56) – Deathbed phenomena & after-death communication(42:08) – Telepathy, remote viewing & “non-local” psychology(45:24) – Quantum physics: analogy not explanation(48:28) – The next generation of researchers(50:06) – What death really is and isn't(51:27) – Is there purpose to the universe?(54:42) – Psychedelics vs NDEs: crucial differences(58:00) – Where does Pim believe he will go after death?(1:01:20) – Final reflectionsEPISODE LINKS:- Pim's Website: https://pimvanlommel.nl/en/- 2001 Lancet Study: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(01)07100-8/abstract- Consciousness Beyond Life: https://www.amazon.com/Consciousness-Beyond-Life-Near-Death-Experience/dp/0061777250CONNECT:- Website: https://mindbodysolution.org - YouTube: https://youtube.com/@MindBodySolution- Podcast: https://creators.spotify.com/pod/show/mindbodysolution- Twitter: https://twitter.com/drtevinnaidu- Facebook: https://facebook.com/drtevinnaidu - Instagram: https://instagram.com/drtevinnaidu- LinkedIn: https://linkedin.com/in/drtevinnaidu- Website: https://tevinnaidu.com=============================Disclaimer: The information provided on this channel is for educational purposes only. The content is shared in the spirit of open discourse and does not constitute, nor does it substitute, professional or medical advice. We do not accept any liability for any loss or damage incurred from you acting or not acting as a result of listening/watching any of our contents. You acknowledge that you use the information provided at your own risk. Listeners/viewers are advised to conduct their own research and consult with their own experts in the respective fields.
This week we're diving into the health stories you'll actually want to know about as we head into December. We're looking at how to beat a hangover and stay well through the festive chaos, from sleep dips to sugar overload. We unpack the rise of wellness washing, why so many “healthy” products are anything but, and how to spot the difference between real wellbeing and clever marketing. Our big story this week is the chronic disease pandemic. A major new Lancet review has brought global attention to the links between modern diets, ultra processed foods and long term illness, exposing the industry forces driving the trend and what the evidence really shows. We break down the key findings and share the simple, realistic habits that genuinely support long term health. Ella's book tour events: https://www.bookbaruk.com/event-details/meet-ella-mills-exclusive-pre-publication-signing-and-meet-greet 50% off code for Quick Wins with Waterstones - ‘QUICKWINS50' (enter the code at checkout) Learn more about your ad choices. Visit podcastchoices.com/adchoices
Send us a textMost people think memory loss is a downhill slide you can't stop. We don't. In this conversation with neurologist and neuroscientist Dr. Majid Fotuhi, we map out a twelve‑week blueprint that measurably improves memory, focus, and even grows hippocampal volume by targeting the real drivers of decline: poor sleep, chronic stress, insulin resistance, hearing loss, inactivity, and hidden medical issues.Dr. Majid Fotuhi is a pioneering neurologist, neuroscientist, and professor with more than thirty-five years of experience in brain health, memory, neuroplasticity, and the prevention of Alzheimer's disease. His work bridges research, clinical innovation, and public education.He earned his PhD in neuroscience from Johns Hopkins University, completed medical training at Harvard Medical School, and returned to Johns Hopkins for his neurology residency. He currently serves as an adjunct professor at Johns Hopkins University.An author and communicator, Dr. Fotuhi has written several books and is known for making complex science accessible. His excellence in teaching earned him the American Academy of Neurology's prestigious award. His research has appeared in peer-reviewed journals, been presented at major conferences, and cited widely by scientists worldwide.Dr. Fotuhi has created a twelve-week program that has helped thousands of patients with memory loss, brain fog, concussion, mild cognitive impairment, and early Alzheimer's disease. His expertise has been featured by CNN, NBC News, the Today Show, ABC News, The New York Times, The Washington Post, and The Times (London).We start by clarifying what mild cognitive impairment is, how it differs from dementia, and why so many cases are preventable. Dr. Fotuhi explains the “type 3 diabetes” model—how decades of sugar spikes and inflammation erode the blood‑brain barrier and starve neurons of a stable environment. Then we get practical. You'll hear how a personalized “brain portfolio” guides treatment: VO2 max testing to shape exercise, sleep studies and CPAP when needed, targeted brain training that matches deficits, and labs for vitamin D, B12, and omega‑3 status. The results? Early wins in two to three weeks, statistically significant gains at six and twelve, and habits that stick.We don't stop at diet and steps. Oral health impacts cognition by limiting whole foods and increasing inflammation; chewing itself engages neural circuits. Hearing loss quietly accelerates decline—hearing aids can move people from mild impairment back to normal. Add a simple, sustainable food approach—ditch ultra‑processed foods, eat vegetables, legumes, fruits, quality proteins, and healthy fats—and consider targeted supplementation with DHA/EPA omega‑3s and corrected D and B12 levels. Along the way, we address why amyloid hogged the spotlight, and point to powerful data: the Lancet's estimate that 45% of dementia cases are preventable and the American Heart Association's claim that 80% of strokes can be avoided.If you want a sharper brain by summer, this is your starting line. Subscribe, share this with someone you love, and leave a review telling us the one habit you'll change this week. Your future brain will thank you.Links:Majid Fotuhi, MD, PhD: https://drfotuhi.com/https://krieger.jhu.edu/mbi/directory/majid-fotuhi/https://neurogrow.com/about-us/dr-majid-fotuhi-md-phd/https://psychology.columbian.gwu.edu/majid-fotuhiTweet me @realdrhamrahIG @drhamrah
Today, we'll be tackling the future of prostate cancer care. We'll be reflecting on what prostate cancer care means in practice, how the way we think about the disease is shifting, and must continue to shift in the years ahead. Scientific advances have transformed treatment in recent years, yet the lived reality of prostate cancer still extends far beyond the clinic. The disease reshapes daily life, and may leave men and their families grappling with difficult choices about how best to manage it. Dr. Güneş Taylor is joined by three key voices at the centre of this story, following the prostate cancer journey from diagnosis through to long-term management, and asking how patients and clinicians can work together to re-think what patient-centred care could mean in the years to come. This episode is brought to you in collaboration with Bayer, part of their Prostate Cancer Perspectives series. PP-UN-ONC-GB-0168. November 2025 References Bray F, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024;74(3):229-263 (Prostate cancer is the second most common cancer in men and the fifth leading cause of cancer death worldwide) James D, et al. The Lancet Commission on prostate cancer: planning for the surge in cases. Lancet. 2024;403(10437):1683–1722 (Each year, around 1.5 million men are diagnosed and nearly 400,000 lose their lives to the disease.1 And the numbers are rising. Diagnoses are projected to double from 1.4 million annually in 2020 to 2.9 million by 2040) Siegel RL, et al. Cancer statistics, 2022. Ca Cancer J Clin. 2022;72:7–33 (In the U.S., the proportion of men diagnosed with advanced-stage prostate cancer has doubled in recent years, due to increasing incidence of advanced-stage disease and changing guidelines regarding the prostate specific antigen screening test, implemented in the U.S. in 2012) Dodkins J, et al. Geographic, socioeconomic and demographic inequalities in the incidence of metastatic prostate cancer at time of diagnosis in England: a population based evaluation. BMJ Oncology. 2025;4:e000643 (In England, nearly one in five men only receive a diagnosis once their cancer has spread) Calvo-Schimmel A, et al. Supportive care interventions and quality of life in advanced disease prostate cancer survivors: An integrative review of the literature. Can Oncol Nurs J. 2021;31(4):412-429 (Advanced prostate cancer is often associated with long-term challenges leading to greater levels of unmet needs in supportive care) Learn more about your ad choices. Visit podcastchoices.com/adchoices
From 18th century London to the promise of a global cure: the 200-year history of Parkinson's disease. To mark the release of our 'Ask the MD' conversation with The Michael J. Fox Foundation for Parkinson's Research, and to welcome a new influx of listeners, we're sharing one of our very first episodes, first aired in August 2024. Watch our full 'Ask the MD' interview, focused on lifestyle strategies for boosting brain health, on the foundation's website: https://www.michaeljfox.org/news/lifestyle-strategies-boost-brain-health-ask-md-video Parkinson's, a neurodegenerative disorder most commonly characterized by tremors and other motor symptoms, is so complex, many medical professionals are starting to classify it as a group of diseases, rather than a single disease. In this episode, we explain those complexities, including: • The motor symptoms (e.g. cogwheel rigidity, bradykinesia) and non-motor symptoms (e.g. depression, sleep disorders) • How the industrial revolution may have brought about environmental factors which contribute to Parkinson's • The differences and similarities between Parkinson's and other neurodegenerative diseases, like Alzheimer's • How Parkinson's manifests in our brains • Why one nurse was able to detect Parkinson's through smell • The neurogenetics of Parkinson's, and the ethical quandaries of evolving genetic technology • Why lifestyle — nutrition, exercise, etc. — is so key to preventing and managing Parkinson's Joining us for this extensive conversation are three incredible guests: • Dr. Rachel Dolhun, Senior Vice President of Medical Communications at The Michael J. Fox Foundation for Parkinson's Research • Dr. Michael Okun, evolutionary biologist, movement disorders specialist, and Director of the Norman Fixel Institute for Neurological Diseases • Dr. Matthew Farrer, neurogenetics expert and Professor Of Neurology at the University of Florida 'Your Brain On' is hosted by neurologists, scientists, and public health advocates Ayesha and Dean Sherzai. SUPPORTED BY: the 2026 NEURO World Retreat. A 5-day journey through science, nature, and community, on the California coastline: https://www.neuroworldretreat.com/ 'Your Brain On... Parkinson's' • SEASON 6 • EPISODE 4 (SEASON 3 REUPLOAD) ————— LINKS Dr. Rachel Dolhun: At the Michael J. Fox Foundation: https://www.michaeljfox.org/bio/rachel-dolhun-md-dipablm 'Ask the MD' series: https://www.michaeljfox.org/ask-md The Michael J. Fox Foundation on YouTube: https://www.youtube.com/@michaeljfoxfoundation/videos Dr. Michael Okun: At the University of Florida: https://neurology.ufl.edu/profile/okun-michael/ The book 'Ending Parkinson's Disease': https://endingpd.org/ The Norman Fixel Institute: https://fixel.ufhealth.org/ Dr. Matthew Farrer: At the University of Florida: https://neurology.ufl.edu/profile/farrer-matthew/ ————— References: Bloem, B. R., Okun, M. S., & Klein, C. (2021). Parkinson's disease. The Lancet, 397(10291), 2284-2303. Morris, H. R., Spillantini, M. G., Sue, C. M., & Williams-Gray, C. H. (2024). The pathogenesis of Parkinson's disease. The Lancet, 403(10423), 293-304. Dorsey, E., Sherer, T., Okun, M. S., & Bloem, B. R. (2018). The emerging evidence of the Parkinson pandemic. Journal of Parkinson's disease, 8(s1), S3-S8. Dorsey, E. R., Okun, M. S., & Tanner, C. M. (2021). Bad Air and Parkinson Disease—The Fog May Be Lifting. JAMA neurology, 78(7), 793-795. Tsalenchuk, M., Gentleman, S. M., & Marzi, S. J. (2023). Linking environmental risk factors with epigenetic mechanisms in Parkinson's disease. npj Parkinson's Disease, 9(1), 123. Reynoso, A., Torricelli, R., Jacobs, B. M., Shi, J., Aslibekyan, S., Norcliffe‐Kaufmann, L., ... & Heilbron, K. (2024). Gene–Environment Interactions for Parkinson's Disease. Annals of Neurology, 95(4), 677-687. Golsorkhi, M., Sherzai, A., & Dashtipour, K. The Influence of Lifestyle on Parkinson's Disease Management. In Lifestyle Medicine, Fourth Edition (pp. 919-924). CRC Press. Sherzai, A. Z., Tagliati, M., Park, K., Pezeshkian, S., & Sherzai, D. (2016). Micronutrients and risk of Parkinson's disease: a systematic review. Gerontology and geriatric medicine, 2, 2333721416644286. ————— FOLLOW US Join NEURO Instagram: @thebraindocs Website: TheBrainDocs.com More info and episodes: TheBrainDocs.com/Podcast
EVEN MORE about this episode!What happens when a Lancet-published physician steps beyond the limits of orthodox medicine and into the mystical? In this episode, Dr. Anona Blackwell joins me, Julie Ryan, to explore the surprising ways science and spirituality intertwine. From telepathy and clairvoyance to the unexpected spiritual awakening sparked by menopause, Anona shares stories that challenge conventional thinking and illuminate her path as a modern-day Welsh “hedge witch.”We dive into the ancient art of dowsing, where intuition becomes a practical tool—even helping locate a lost Jack Russell in South Wales. Anona also recounts touching and humorous moments from her childhood spirit encounters to her unforgettable meetings with King Charles, revealing the gentle overlap between the mystical and the mainstream.Our conversation culminates in a profound exploration of energy healing, past lives, and the spiritual blueprint that persists beyond death. With love, humor, and wisdom woven throughout, this episode bridges Sweet Home Alabama and Wales—inviting you to expand your understanding of holistic health, soul purpose, and the unseen forces guiding us all.Guest Biography:Dr. Anona Blackwell is a Lancet-published academic physician and leading authority in genitourinary medicine whose lifelong curiosity about the universe has led her to explore the intersection of science and spirituality. Raised on a small holding in rural Wales, she rose from humble beginnings to spearhead research that transformed women's health care in the UK, all while privately investigating anomalous phenomena, energy healing, and her own innate psychic abilities. Her memoir, From Medic to Mystic, chronicles her journey from orthodox-trained doctor to unapologetic mystic, sharing compelling evidence from her clinical and personal life—telepathy, clairvoyance, NDEs, life after death, the power of prayer—and encouraging others to speak openly about their extraordinary experiences.Episode Chapters:(00:00) - Spirituality and Science Blend(14:22) - Dowsing and Pendulums in Finding(17:37) - Childhood Spirit Friend and Royal Encounter(23:58) - Encounters With Prince Charles(28:45) - Healing Past Lives and Energy Blocks(38:23) - Healing and Spirituality in Medicine(47:14) - Connecting With Spirit and Angels➡️Subscribe to Ask Julie Ryan YouTube➡️Subscribe to Ask Julie Ryan Español YouTube➡️Subscribe to Ask Julie Ryan Português YouTube➡️Subscribe to Ask Julie Ryan Deutsch YouTube➡️Subscribe to Ask Julie Ryan Français YouTube✏️Ask Julie a Question!
Americans are currently besotted with protein. It's touted as being good for muscle growth, weight loss, skincare, mental acuity, longevity, and much else besides. It's sold to men, women, children, the elderly— you can even buy protein for your pets. The protein supplement market alone is worth $21 billion and growing—and extra protein is being added to coffee, cereal, pasta, beer, ice cream, and popcorn. But as frenzied as we currently are about protein, this is not the first protein boom—or even the second. Protein has been promoted as a charismatic, cure-all nutrient for nearly two centuries. In this episode, with the help of Samantha King and Gavin Weedon, the authors of Protein: The Making of a Nutritional Superstar, we look closely at all our protein crazes and their associated protein products—from beef tea to whey powder—and see what they can tell us about our current protein mania. This episode was produced by Max Freedman. Decoder Ring is also produced by Willa Paskin, Katie Shepherd, and Evan Chung, our supervising producer. We had editing support from Josh Levin and fact-checking by Sophie Summergrad. Merritt Jacob is Senior Technical Director. If you have any cultural mysteries you want us to decode, email us at DecoderRing@slate.com or leave a message on our hotline at (347) 460-7281. Get more of Decoder Ring with Slate Plus! Join for exclusive bonus episodes of Decoder Ring and ad-free listening on all your favorite Slate podcasts. Subscribe from the Decoder Ring show page on Apple Podcasts or Spotify. Or, visit slate.com/decoderplus for access wherever you listen. Sources for This Episode King, Samantha and Gavin Weedon. Protein: The Making of a Nutritional Superstar, Duke University Press, 2026. Baker, Ryan. “Protein has become America's latest obsession. Companies like General Mills and PepsiCo are capitalizing on it,” CNBC, July 22, 2025. Brock, William H. Justus von Liebig: The Chemical Gatekeeper, Cambridge University Press, 1997. Callahan, Alice. “The More Protein, the Better?” New York Times, April 9, 2025. Draper, Kevin. “America's Protein Obsession Is Transforming the Dairy Industry,” New York Times, July 16, 2025. Gayomali, Chris. “Big Food Gets Jacked: How protein mania took over the American grocery store,” New York Magazine, Feb. 12, 2025. “The Great Protein Fiasco,” Maintenance Phase, Aug. 31, 2021. Liebig, Justus von. Researches on the Chemistry of Food, Taylor and Walton, 1847. McLaren, Donald S. “The Great Protein Fiasco,” The Lancet, 1974. Oncken, John. “Stingy, 'half-way' dairy farmer's curiosity changed the world,” Wisconsin State Farmer, April 27, 2022. “Subject of Whey Disposal Discussed in UW Bulletin.” Wausau Daily Herald, Aug. 28, 1965. Torrella, Kenny. “You're probably eating way too much protein,” Vox, Jan. 30, 2024. Wilson, Bee. “Protein mania: the rich world's new diet obsession,” The Guardian, Jan. 4, 2019. Wu, Katherine J. “Should We All Be Eating Like The Rock?” The Atlantic, Aug. 28, 2023. Learn more about your ad choices. Visit megaphone.fm/adchoices
Americans are currently besotted with protein. It's touted as being good for muscle growth, weight loss, skincare, mental acuity, longevity, and much else besides. It's sold to men, women, children, the elderly— you can even buy protein for your pets. The protein supplement market alone is worth $21 billion and growing—and extra protein is being added to coffee, cereal, pasta, beer, ice cream, and popcorn.But as frenzied as we currently are about protein, this is not the first protein boom—or even the second. Protein has been promoted as a charismatic, cure-all nutrient for nearly two centuries. In this episode, with the help of Samantha King and Gavin Weedon, the authors of Protein: The Making of a Nutritional Superstar, we look closely at all our protein crazes and their associated protein products—from beef tea to whey powder—and see what they can tell us about our current protein mania. This episode was produced by Max Freedman. Decoder Ring is also produced by Willa Paskin, Katie Shepherd, and Evan Chung, our supervising producer. We had editing support from Josh Levin and fact-checking by Sophie Summergrad. Merritt Jacob is Senior Technical Director.If you have any cultural mysteries you want us to decode, email us at DecoderRing@slate.com or leave a message on our hotline at (347) 460-7281.Get more of Decoder Ring with Slate Plus! Join for exclusive bonus episodes of Decoder Ring and ad-free listening on all your favorite Slate podcasts. Subscribe from the Decoder Ring show page on Apple Podcasts or Spotify. Or, visit slate.com/decoderplus for access wherever you listen.Sources for This EpisodeKing, Samantha and Gavin Weedon. Protein: The Making of a Nutritional Superstar, Duke University Press, 2026.Baker, Ryan. “Protein has become America's latest obsession. Companies like General Mills and PepsiCo are capitalizing on it,” CNBC, July 22, 2025.Brock, William H. Justus von Liebig: The Chemical Gatekeeper, Cambridge University Press, 1997.Callahan, Alice. “The More Protein, the Better?” New York Times, April 9, 2025.Draper, Kevin. “America's Protein Obsession Is Transforming the Dairy Industry,” New York Times, July 16, 2025.Gayomali, Chris. “Big Food Gets Jacked: How protein mania took over the American grocery store,” New York Magazine, Feb. 12, 2025.“The Great Protein Fiasco,” Maintenance Phase, Aug. 31, 2021.Liebig, Justus von. Researches on the Chemistry of Food, Taylor and Walton, 1847.McLaren, Donald S. “The Great Protein Fiasco,” The Lancet, 1974.Oncken, John. “Stingy, 'half-way' dairy farmer's curiosity changed the world,” Wisconsin State Farmer, April 27, 2022.“Subject of Whey Disposal Discussed in UW Bulletin.” Wausau Daily Herald, Aug. 28, 1965.Torrella, Kenny. “You're probably eating way too much protein,” Vox, Jan. 30, 2024.Wilson, Bee. “Protein mania: the rich world's new diet obsession,” The Guardian, Jan. 4, 2019.Wu, Katherine J. “Should We All Be Eating Like The Rock?” The Atlantic, Aug. 28, 2023. Hosted on Acast. See acast.com/privacy for more information.
Americans are currently besotted with protein. It's touted as being good for muscle growth, weight loss, skincare, mental acuity, longevity, and much else besides. It's sold to men, women, children, the elderly— you can even buy protein for your pets. The protein supplement market alone is worth $21 billion and growing—and extra protein is being added to coffee, cereal, pasta, beer, ice cream, and popcorn.But as frenzied as we currently are about protein, this is not the first protein boom—or even the second. Protein has been promoted as a charismatic, cure-all nutrient for nearly two centuries. In this episode, with the help of Samantha King and Gavin Weedon, the authors of Protein: The Making of a Nutritional Superstar, we look closely at all our protein crazes and their associated protein products—from beef tea to whey powder—and see what they can tell us about our current protein mania. This episode was produced by Max Freedman. Decoder Ring is also produced by Willa Paskin, Katie Shepherd, and Evan Chung, our supervising producer. We had editing support from Josh Levin and fact-checking by Sophie Summergrad. Merritt Jacob is Senior Technical Director.If you have any cultural mysteries you want us to decode, email us at DecoderRing@slate.com or leave a message on our hotline at (347) 460-7281.Get more of Decoder Ring with Slate Plus! Join for exclusive bonus episodes of Decoder Ring and ad-free listening on all your favorite Slate podcasts. Subscribe from the Decoder Ring show page on Apple Podcasts or Spotify. Or, visit slate.com/decoderplus for access wherever you listen.Sources for This EpisodeKing, Samantha and Gavin Weedon. Protein: The Making of a Nutritional Superstar, Duke University Press, 2026.Baker, Ryan. “Protein has become America's latest obsession. Companies like General Mills and PepsiCo are capitalizing on it,” CNBC, July 22, 2025.Brock, William H. Justus von Liebig: The Chemical Gatekeeper, Cambridge University Press, 1997.Callahan, Alice. “The More Protein, the Better?” New York Times, April 9, 2025.Draper, Kevin. “America's Protein Obsession Is Transforming the Dairy Industry,” New York Times, July 16, 2025.Gayomali, Chris. “Big Food Gets Jacked: How protein mania took over the American grocery store,” New York Magazine, Feb. 12, 2025.“The Great Protein Fiasco,” Maintenance Phase, Aug. 31, 2021.Liebig, Justus von. Researches on the Chemistry of Food, Taylor and Walton, 1847.McLaren, Donald S. “The Great Protein Fiasco,” The Lancet, 1974.Oncken, John. “Stingy, 'half-way' dairy farmer's curiosity changed the world,” Wisconsin State Farmer, April 27, 2022.“Subject of Whey Disposal Discussed in UW Bulletin.” Wausau Daily Herald, Aug. 28, 1965.Torrella, Kenny. “You're probably eating way too much protein,” Vox, Jan. 30, 2024.Wilson, Bee. “Protein mania: the rich world's new diet obsession,” The Guardian, Jan. 4, 2019.Wu, Katherine J. “Should We All Be Eating Like The Rock?” The Atlantic, Aug. 28, 2023. Hosted on Acast. See acast.com/privacy for more information.
Americans are currently besotted with protein. It's touted as being good for muscle growth, weight loss, skincare, mental acuity, longevity, and much else besides. It's sold to men, women, children, the elderly— you can even buy protein for your pets. The protein supplement market alone is worth $21 billion and growing—and extra protein is being added to coffee, cereal, pasta, beer, ice cream, and popcorn. But as frenzied as we currently are about protein, this is not the first protein boom—or even the second. Protein has been promoted as a charismatic, cure-all nutrient for nearly two centuries. In this episode, with the help of Samantha King and Gavin Weedon, the authors of Protein: The Making of a Nutritional Superstar, we look closely at all our protein crazes and their associated protein products—from beef tea to whey powder—and see what they can tell us about our current protein mania. This episode was produced by Max Freedman. Decoder Ring is also produced by Willa Paskin, Katie Shepherd, and Evan Chung, our supervising producer. We had editing support from Josh Levin and fact-checking by Sophie Summergrad. Merritt Jacob is Senior Technical Director. If you have any cultural mysteries you want us to decode, email us at DecoderRing@slate.com or leave a message on our hotline at (347) 460-7281. Get more of Decoder Ring with Slate Plus! Join for exclusive bonus episodes of Decoder Ring and ad-free listening on all your favorite Slate podcasts. Subscribe from the Decoder Ring show page on Apple Podcasts or Spotify. Or, visit slate.com/decoderplus for access wherever you listen. Sources for This Episode King, Samantha and Gavin Weedon. Protein: The Making of a Nutritional Superstar, Duke University Press, 2026. Baker, Ryan. “Protein has become America's latest obsession. Companies like General Mills and PepsiCo are capitalizing on it,” CNBC, July 22, 2025. Brock, William H. Justus von Liebig: The Chemical Gatekeeper, Cambridge University Press, 1997. Callahan, Alice. “The More Protein, the Better?” New York Times, April 9, 2025. Draper, Kevin. “America's Protein Obsession Is Transforming the Dairy Industry,” New York Times, July 16, 2025. Gayomali, Chris. “Big Food Gets Jacked: How protein mania took over the American grocery store,” New York Magazine, Feb. 12, 2025. “The Great Protein Fiasco,” Maintenance Phase, Aug. 31, 2021. Liebig, Justus von. Researches on the Chemistry of Food, Taylor and Walton, 1847. McLaren, Donald S. “The Great Protein Fiasco,” The Lancet, 1974. Oncken, John. “Stingy, 'half-way' dairy farmer's curiosity changed the world,” Wisconsin State Farmer, April 27, 2022. “Subject of Whey Disposal Discussed in UW Bulletin.” Wausau Daily Herald, Aug. 28, 1965. Torrella, Kenny. “You're probably eating way too much protein,” Vox, Jan. 30, 2024. Wilson, Bee. “Protein mania: the rich world's new diet obsession,” The Guardian, Jan. 4, 2019. Wu, Katherine J. “Should We All Be Eating Like The Rock?” The Atlantic, Aug. 28, 2023. Learn more about your ad choices. Visit megaphone.fm/adchoices
Americans are currently besotted with protein. It's touted as being good for muscle growth, weight loss, skincare, mental acuity, longevity, and much else besides. It's sold to men, women, children, the elderly— you can even buy protein for your pets. The protein supplement market alone is worth $21 billion and growing—and extra protein is being added to coffee, cereal, pasta, beer, ice cream, and popcorn.But as frenzied as we currently are about protein, this is not the first protein boom—or even the second. Protein has been promoted as a charismatic, cure-all nutrient for nearly two centuries. In this episode, with the help of Samantha King and Gavin Weedon, the authors of Protein: The Making of a Nutritional Superstar, we look closely at all our protein crazes and their associated protein products—from beef tea to whey powder—and see what they can tell us about our current protein mania. This episode was produced by Max Freedman. Decoder Ring is also produced by Willa Paskin, Katie Shepherd, and Evan Chung, our supervising producer. We had editing support from Josh Levin and fact-checking by Sophie Summergrad. Merritt Jacob is Senior Technical Director.If you have any cultural mysteries you want us to decode, email us at DecoderRing@slate.com or leave a message on our hotline at (347) 460-7281.Get more of Decoder Ring with Slate Plus! Join for exclusive bonus episodes of Decoder Ring and ad-free listening on all your favorite Slate podcasts. Subscribe from the Decoder Ring show page on Apple Podcasts or Spotify. Or, visit slate.com/decoderplus for access wherever you listen.Sources for This EpisodeKing, Samantha and Gavin Weedon. Protein: The Making of a Nutritional Superstar, Duke University Press, 2026.Baker, Ryan. “Protein has become America's latest obsession. Companies like General Mills and PepsiCo are capitalizing on it,” CNBC, July 22, 2025.Brock, William H. Justus von Liebig: The Chemical Gatekeeper, Cambridge University Press, 1997.Callahan, Alice. “The More Protein, the Better?” New York Times, April 9, 2025.Draper, Kevin. “America's Protein Obsession Is Transforming the Dairy Industry,” New York Times, July 16, 2025.Gayomali, Chris. “Big Food Gets Jacked: How protein mania took over the American grocery store,” New York Magazine, Feb. 12, 2025.“The Great Protein Fiasco,” Maintenance Phase, Aug. 31, 2021.Liebig, Justus von. Researches on the Chemistry of Food, Taylor and Walton, 1847.McLaren, Donald S. “The Great Protein Fiasco,” The Lancet, 1974.Oncken, John. “Stingy, 'half-way' dairy farmer's curiosity changed the world,” Wisconsin State Farmer, April 27, 2022.“Subject of Whey Disposal Discussed in UW Bulletin.” Wausau Daily Herald, Aug. 28, 1965.Torrella, Kenny. “You're probably eating way too much protein,” Vox, Jan. 30, 2024.Wilson, Bee. “Protein mania: the rich world's new diet obsession,” The Guardian, Jan. 4, 2019.Wu, Katherine J. “Should We All Be Eating Like The Rock?” The Atlantic, Aug. 28, 2023. Hosted on Acast. See acast.com/privacy for more information.
Americans are currently besotted with protein. It's touted as being good for muscle growth, weight loss, skincare, mental acuity, longevity, and much else besides. It's sold to men, women, children, the elderly— you can even buy protein for your pets. The protein supplement market alone is worth $21 billion and growing—and extra protein is being added to coffee, cereal, pasta, beer, ice cream, and popcorn. But as frenzied as we currently are about protein, this is not the first protein boom—or even the second. Protein has been promoted as a charismatic, cure-all nutrient for nearly two centuries. In this episode, with the help of Samantha King and Gavin Weedon, the authors of Protein: The Making of a Nutritional Superstar, we look closely at all our protein crazes and their associated protein products—from beef tea to whey powder—and see what they can tell us about our current protein mania. This episode was produced by Max Freedman. Decoder Ring is also produced by Willa Paskin, Katie Shepherd, and Evan Chung, our supervising producer. We had editing support from Josh Levin and fact-checking by Sophie Summergrad. Merritt Jacob is Senior Technical Director. If you have any cultural mysteries you want us to decode, email us at DecoderRing@slate.com or leave a message on our hotline at (347) 460-7281. Get more of Decoder Ring with Slate Plus! Join for exclusive bonus episodes of Decoder Ring and ad-free listening on all your favorite Slate podcasts. Subscribe from the Decoder Ring show page on Apple Podcasts or Spotify. Or, visit slate.com/decoderplus for access wherever you listen. Sources for This Episode King, Samantha and Gavin Weedon. Protein: The Making of a Nutritional Superstar, Duke University Press, 2026. Baker, Ryan. “Protein has become America's latest obsession. Companies like General Mills and PepsiCo are capitalizing on it,” CNBC, July 22, 2025. Brock, William H. Justus von Liebig: The Chemical Gatekeeper, Cambridge University Press, 1997. Callahan, Alice. “The More Protein, the Better?” New York Times, April 9, 2025. Draper, Kevin. “America's Protein Obsession Is Transforming the Dairy Industry,” New York Times, July 16, 2025. Gayomali, Chris. “Big Food Gets Jacked: How protein mania took over the American grocery store,” New York Magazine, Feb. 12, 2025. “The Great Protein Fiasco,” Maintenance Phase, Aug. 31, 2021. Liebig, Justus von. Researches on the Chemistry of Food, Taylor and Walton, 1847. McLaren, Donald S. “The Great Protein Fiasco,” The Lancet, 1974. Oncken, John. “Stingy, 'half-way' dairy farmer's curiosity changed the world,” Wisconsin State Farmer, April 27, 2022. “Subject of Whey Disposal Discussed in UW Bulletin.” Wausau Daily Herald, Aug. 28, 1965. Torrella, Kenny. “You're probably eating way too much protein,” Vox, Jan. 30, 2024. Wilson, Bee. “Protein mania: the rich world's new diet obsession,” The Guardian, Jan. 4, 2019. Wu, Katherine J. “Should We All Be Eating Like The Rock?” The Atlantic, Aug. 28, 2023. Learn more about your ad choices. Visit megaphone.fm/adchoices
Americans are currently besotted with protein. It's touted as being good for muscle growth, weight loss, skincare, mental acuity, longevity, and much else besides. It's sold to men, women, children, the elderly— you can even buy protein for your pets. The protein supplement market alone is worth $21 billion and growing—and extra protein is being added to coffee, cereal, pasta, beer, ice cream, and popcorn.But as frenzied as we currently are about protein, this is not the first protein boom—or even the second. Protein has been promoted as a charismatic, cure-all nutrient for nearly two centuries. In this episode, with the help of Samantha King and Gavin Weedon, the authors of Protein: The Making of a Nutritional Superstar, we look closely at all our protein crazes and their associated protein products—from beef tea to whey powder—and see what they can tell us about our current protein mania. This episode was produced by Max Freedman. Decoder Ring is also produced by Willa Paskin, Katie Shepherd, and Evan Chung, our supervising producer. We had editing support from Josh Levin and fact-checking by Sophie Summergrad. Merritt Jacob is Senior Technical Director.If you have any cultural mysteries you want us to decode, email us at DecoderRing@slate.com or leave a message on our hotline at (347) 460-7281.Get more of Decoder Ring with Slate Plus! Join for exclusive bonus episodes of Decoder Ring and ad-free listening on all your favorite Slate podcasts. Subscribe from the Decoder Ring show page on Apple Podcasts or Spotify. Or, visit slate.com/decoderplus for access wherever you listen.Sources for This EpisodeKing, Samantha and Gavin Weedon. Protein: The Making of a Nutritional Superstar, Duke University Press, 2026.Baker, Ryan. “Protein has become America's latest obsession. Companies like General Mills and PepsiCo are capitalizing on it,” CNBC, July 22, 2025.Brock, William H. Justus von Liebig: The Chemical Gatekeeper, Cambridge University Press, 1997.Callahan, Alice. “The More Protein, the Better?” New York Times, April 9, 2025.Draper, Kevin. “America's Protein Obsession Is Transforming the Dairy Industry,” New York Times, July 16, 2025.Gayomali, Chris. “Big Food Gets Jacked: How protein mania took over the American grocery store,” New York Magazine, Feb. 12, 2025.“The Great Protein Fiasco,” Maintenance Phase, Aug. 31, 2021.Liebig, Justus von. Researches on the Chemistry of Food, Taylor and Walton, 1847.McLaren, Donald S. “The Great Protein Fiasco,” The Lancet, 1974.Oncken, John. “Stingy, 'half-way' dairy farmer's curiosity changed the world,” Wisconsin State Farmer, April 27, 2022.“Subject of Whey Disposal Discussed in UW Bulletin.” Wausau Daily Herald, Aug. 28, 1965.Torrella, Kenny. “You're probably eating way too much protein,” Vox, Jan. 30, 2024.Wilson, Bee. “Protein mania: the rich world's new diet obsession,” The Guardian, Jan. 4, 2019.Wu, Katherine J. “Should We All Be Eating Like The Rock?” The Atlantic, Aug. 28, 2023. Hosted on Acast. See acast.com/privacy for more information.
Americans are currently besotted with protein. It's touted as being good for muscle growth, weight loss, skincare, mental acuity, longevity, and much else besides. It's sold to men, women, children, the elderly— you can even buy protein for your pets. The protein supplement market alone is worth $21 billion and growing—and extra protein is being added to coffee, cereal, pasta, beer, ice cream, and popcorn. But as frenzied as we currently are about protein, this is not the first protein boom—or even the second. Protein has been promoted as a charismatic, cure-all nutrient for nearly two centuries. In this episode, with the help of Samantha King and Gavin Weedon, the authors of Protein: The Making of a Nutritional Superstar, we look closely at all our protein crazes and their associated protein products—from beef tea to whey powder—and see what they can tell us about our current protein mania. This episode was produced by Max Freedman. Decoder Ring is also produced by Willa Paskin, Katie Shepherd, and Evan Chung, our supervising producer. We had editing support from Josh Levin and fact-checking by Sophie Summergrad. Merritt Jacob is Senior Technical Director. If you have any cultural mysteries you want us to decode, email us at DecoderRing@slate.com or leave a message on our hotline at (347) 460-7281. Get more of Decoder Ring with Slate Plus! Join for exclusive bonus episodes of Decoder Ring and ad-free listening on all your favorite Slate podcasts. Subscribe from the Decoder Ring show page on Apple Podcasts or Spotify. Or, visit slate.com/decoderplus for access wherever you listen. Sources for This Episode King, Samantha and Gavin Weedon. Protein: The Making of a Nutritional Superstar, Duke University Press, 2026. Baker, Ryan. “Protein has become America's latest obsession. Companies like General Mills and PepsiCo are capitalizing on it,” CNBC, July 22, 2025. Brock, William H. Justus von Liebig: The Chemical Gatekeeper, Cambridge University Press, 1997. Callahan, Alice. “The More Protein, the Better?” New York Times, April 9, 2025. Draper, Kevin. “America's Protein Obsession Is Transforming the Dairy Industry,” New York Times, July 16, 2025. Gayomali, Chris. “Big Food Gets Jacked: How protein mania took over the American grocery store,” New York Magazine, Feb. 12, 2025. “The Great Protein Fiasco,” Maintenance Phase, Aug. 31, 2021. Liebig, Justus von. Researches on the Chemistry of Food, Taylor and Walton, 1847. McLaren, Donald S. “The Great Protein Fiasco,” The Lancet, 1974. Oncken, John. “Stingy, 'half-way' dairy farmer's curiosity changed the world,” Wisconsin State Farmer, April 27, 2022. “Subject of Whey Disposal Discussed in UW Bulletin.” Wausau Daily Herald, Aug. 28, 1965. Torrella, Kenny. “You're probably eating way too much protein,” Vox, Jan. 30, 2024. Wilson, Bee. “Protein mania: the rich world's new diet obsession,” The Guardian, Jan. 4, 2019. Wu, Katherine J. “Should We All Be Eating Like The Rock?” The Atlantic, Aug. 28, 2023. Learn more about your ad choices. Visit megaphone.fm/adchoices
Links mentioned ⬇️Lancet 2024 risk factor PDFMy Alzheimer's risk episode⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯Where to find Barbie ⬇️InstagramSubstack⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯Where to find me ⬇️InstagramPodcast⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯My group program ⬇️WOMP Training [Gym + Home]⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯Helping you find the balance between OPTIMAL and PRACTICAL
Credits: 0.25 AMA PRA Category 1 Credit™ CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-459 Overview: Cognitive decline risk may be reduced through modifiable lifestyle factors, creating an opportunity for early intervention in primary care. Join us as we review findings from the US POINTER trial, which evaluated the impact of structured vs. self-guided lifestyle interventions on the risk of cognitive decline in older adults. Come away with tips to apply this evidence in real-world scenarios with your patients. Episode resource links: Baker LD, Espeland MA, Whitmer RA, et al. Structured vs self-guided multidomain lifestyle interventions for global cognitive function: The US POINTER randomized clinical trial. JAMA. 2025;334(8):681-691. doi:10.1001/jama.2025.12923 Livingston G, Huntley J, Liu KY, et al. Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission. Lancet. 2024;404(10421):572-628. doi:10.1016/S0140-6736(24)01296-0 Guest: Jillian Joseph, MPAS, PA-C Music Credit: Matthew Bugos Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com
It's In the News.. a look at the top headlines and stories in the diabetes community. This week's top stories: It's World Diabetes Day and we have a LOT of news to get to! Daily oral insulin tested to prevent T1D, mothers and sons and a T1D link, stem cell updates, Tandem Android news, Omnipod's workplace campaign and more! Find out how to submit your Community Commercial Find out more about Moms' Night Out Please visit our Sponsors & Partners - they help make the show possible! Learn more about Gvoke Glucagon Gvoke HypoPen® (glucagon injection): Glucagon Injection For Very Low Blood Sugar (gvokeglucagon.com) Omnipod - Simplify Life Learn about Dexcom Check out VIVI Cap to protect your insulin from extreme temperatures The best way to keep up with Stacey and the show is by signing up for our weekly newsletter: Sign up for our newsletter here Here's where to find us: Facebook (Group) Facebook (Page) Instagram Twitter Check out Stacey's books! Learn more about everything at our home page www.diabetes-connections.com Reach out with questions or comments: info@diabetes-connections.com Episode transcription with links: Hello and welcome to Diabetes Connections In the News! I'm Stacey Simms and every other Friday I bring you a short episode with the top diabetes stories and headlines happening now. It's world diabetes day! It is marked every year on 14 November, the birthday of Sir Frederick Banting, who co-discovered insulin along with Charles Best in 1922. WDD was created in 1991 by International Diabetes Federation (IDF) and the World Health Organization and became an official United Nations Day in 2006 with the passage of United Nations Resolution 61/225. There will be a ton of stuff in your feeds today and that's great! I'm going to keep this to a pretty normal in the news episode.. although I do have my own World Diabetes Day announcement – I want YOUR community commercials. You could have an ad for your event or your blog or your project right here! There's a post on the website explaining it all and I'll come back at the end of the episode and tell you more. XX The Primary Oral Insulin Trial (POInT) is the first large-scale clinical trial to test whether giving at-risk children daily oral insulin could prevent or delay type 1 diabetes (T1D). Conducted by researchers from Helmholtz Munich and the Technical University of Munich across five European countries, the study enrolled more than 1,000 children with a genetic risk for T1D. Results published in The Lancet show that while oral insulin did not prevent the development of islet autoantibodies—an early sign of diabetes—it was safe and well tolerated. Importantly, researchers found that some children who received oral insulin developed diabetes more slowly than those given a placebo, suggesting potential protective effects in certain genetic subgroups. Further analysis revealed that the response to treatment depended on the child's insulin gene variant. Children with genetic versions that raise diabetes risk appeared to benefit, showing delayed onset of the disease, while those without the risk variant did not. These findings point toward a future of personalized prevention, where genetic screening could help identify which children might benefit most from oral insulin. Researchers will continue following the participants until age 12 to assess long-term effects. The study marks a major milestone in decades of diabetes prevention research, highlighting both the promise and complexity of developing tailored, early interventions against type 1 diabetes. XX Joint US-Chinese research looking at generating new beta cells from stomach cells. Upon turning on the "genetic switch," the human stomach cells were converted to insulin-secreting cells within the mice and resembled pancreatic beta cells with respect to gene and protein expression. Encouragingly, when those experiments were done with diabetic mice, insulin secreted from the transformed human cells helped control blood sugar levels and ameliorated diabetes. The scientists hope that a similar approach can be taken to convert cells from a patient's own stomach into insulin-secreting cells directly within the body. Importantly, additional studies are needed to address if this approach is safe and effective to be used in patients. https://www.technologynetworks.com/cell-science/news/human-stomach-cells-tweaked-to-make-insulin-406694 XX A new study in Nature Metabolism may help explain why children born to mothers with type 1 diabetes are less likely to develop the disease early in life compared to those whose fathers or siblings have it. Researchers looked at nearly 2,000 mothers and their children and found that kids whose moms have type 1 diabetes show changes in their DNA that may actually help protect them. These aren't genetic mutations, but epigenetic changes — chemical tags that turn certain genes on or off. The study found these changes in genes tied to the immune system and type 1 diabetes risk, suggesting that a mother's condition during pregnancy can shape her child's immune response in a protective way. Scientists identified more than 500 areas of DNA where these changes occurred, many in regions that control how the body's immune system works. Most of the changes appeared to calm down the kind of overactive immune response that leads to type 1 diabetes. Researchers even created a "methylation score" to help measure this protective effect. They say the next step is to confirm these results in more diverse groups and figure out exactly how these DNA changes help prevent early diabetes. https://www.news-medical.net/news/20251110/Maternal-type-1-diabetes-may-protect-children-from-developing-the-disease.aspx XX A new study from Karolinska Institutet and Stockholm University reveals that sons born to mothers with type 1 diabetes may develop early vascular dysfunction—independently of metabolic health. The finding may help shape future strategies to prevent cardiovascular disease early in life. Children of women with type 1 diabetes are known to be at increased risk of developing cardiovascular diseases. This new study, published in Cell Reports Medicine, is the first to show that the risk is linked to early dysfunction in blood vessel cells in sons, even before any metabolic issues arise. The team is now investigating the long-term effects of maternal diabetes, with a particular focus on why sons seem to be affected earlier than daughters. https://medicalxpress.com/news/2025-11-sons-mothers-diabetes-early-vascular.html XX A new study presented at Kidney Week 2025 has shown that the drug finn-uh-near-own a nonsteroidal mineralocorticoid-receptor antagonist, significantly reduced albuminuria—a key marker of kidney damage—in people with type 1 diabetes (T1D) and chronic kidney disease (CKD). This is the first major breakthrough for this population in more than 30 years. Researchers found that patients taking finerenone saw a 25% average reduction in albuminuria compared to placebo, an improvement that suggests a lower long-term risk for dialysis or kidney transplant. The phase 3 FINE-ONE trial involved 242 adults with T1D and CKD, and results showed benefits as early as three months. The drug was generally well tolerated, with side effects similar to those seen in patients with type 2 diabetes, though mild hyperkalemia (high potassium levels) was slightly more common. Experts say the findings could change the way doctors treat kidney complications in type 1 diabetes, an area that hasn't seen new therapies since the early 1990s. Currently, treatment options rely on blood pressure and blood sugar management, along with renin-angiotensin system (RAS) inhibitors. Finerenone, which is already approved for type 2 diabetes-related CKD, targets overactivation of a receptor that drives kidney damage. Based on these results, Bayer plans to seek FDA approval in 2026 for use in people with T1D and CKD. Researchers and clinicians alike are calling the study "groundbreaking," noting that it opens the door to future research on how finerenone might not just slow kidney decline—but possibly prevent it altogether. https://www.medscape.com/viewarticle/finerenone-offers-hope-kidney-disease-type-1-diabetes-2025a1000uzi?form=login XX This week, Tandem Diabetes Care (Nasdaq:TNDM) announced a major milestone for its Mobi miniature durable insulin pump system. San Diego-based Tandem revealed that it received FDA approval for the Android version of its Mobi mobile app. Clearance brings Mobi — which the company describes as the world's smallest, durable automated insulin delivery system — to more users. The pump, which pairs with Tandem's Control-IQ+ algorithm, previously worked with iOS software. Tandem — one of the largest diabetes tech companies in the world — expects to begin a limited rollout next month, followed by full commercial availability in early 2026. This marks the latest milestone for the company, which continues to expand its offerings and widen its reach within the diabetes patient population. We had a great interview with Tandem on our previous episode, but as I said at the time, it was coming before their earnings call. So here's an update: The company plans to submit the tubeless mobi to the fda before the end of this year.. possible approval and shipping date is hoped for by middle of 2026. Trials for their fully closed loop next-generation algorithm which we tlkaed abou ton the show should be launched in 2026 The Sigi patch pump will be developed and launched as a next-generation version of the Mobi Great job by Dr. David ? Ahn – he posted on IG after getting a message from tandem CEO John Sheridan? 1. First, the Tandem X3 *is* still absolutely in development, contrary to my speculation In yesterday's video. As many of you appropriately pointed out, there is definitely a market for a 300 unit pump, a pump with a screen, and a pump that does not require smartphone control. So from our brief chat, the sense I got that is that the X3 would be more of a refresh of the X2 with newer components, such as a USB-C connector and better memory, rather than a total redesign from the ground up. In terms of timing, all I could get was that it was "not too far distant in the future," which could mean anything I guess, but at least it's still on the way! 2. Next up, he also reassured me that they are working closely with Dexcom to support the G7 15 Day sensor within the next few months. I suspected as much, but it's always good to hear confirmation. 3. Lastly, he did confirm that Tandem is far along in developing a Caregiver/Follow app to allow the remote viewing of glucose and insulin data from a Tandem pump. He explained that it will be based on Sugarmate, the popular diabetes data dashboard app that Tandem acquired back in Jun 2020. While I don't know if every feature will make it into the Tandem caregiver app, Sugarmate is well-liked for its highly customizable dashboard and highly configurable alerts. Sugarmate even has the option to send a text message or phone call for urgent lows. Regardless, a true follow/Caregiver app will be welcomed with open arms by all caregivers and Tandem users who use Libre 3 Plus. https://time.com/7318020/worlds-top-healthtech-companies-2025/ XX Senseonics submits Eversense 365 – their year long implantable CGM for a CE mark, European Approval and expect to launch there soon. Eversense will be integrated with the sequel twist pump – again I'm hearing soon but no timeline. Intersting to note that one year inseration was approved in the US just about a year ago, so the first patients will be having their CGMs changed out – for the first time – pretty soon. https://www.drugdeliverybusiness.com/senseonics-q2-2025-sales-beat-ce-mark/ XX A confusing study out of Rutgers - these researcher say metformin reduces some of the key benefits normally gained from regular physical activity. These include improvements in blood vessel health, physical fitness, and the body's ability to regulate blood sugar. Since 2006, doctors have typically encouraged patients with elevated blood sugar levels to combine metformin with exercise, expecting that the two proven treatments would produce stronger results together. However, the new research suggests this may not be the case. In this study, Exercise alone improved vascular insulin sensitivity, meaning blood vessels responded better to insulin and allowed more blood flow to muscles. This matters because insulin's ability to open blood vessels helps shuttle glucose out of the bloodstream and into tissues, lowering blood sugar after meals. But when metformin was added, the improvements shrank. The drug also diminished gains in aerobic fitness and reduced the positive effects on inflammation and fasting glucose. The findings don't mean people should stop taking metformin or exercising, Malin said. Instead, it raises urgent questions for doctors about how the two treatments can be combined and the need for close monitoring. Malin hopes future research will uncover strategies that preserve the benefits of both. https://scitechdaily.com/popular-diabetes-drug-metformin-may-cancel-out-exercise-benefits-study-warns/ XX XX https://www.medtechdive.com/news/Revvity-Sanofi-diabetes-test-Kihealth-seed-round/802133/ XX Dexcom recalled an Android app for its G6 glucose sensor due to a software problem that could cause the app to terminate unexpectedly. The issue could cause users to miss alarms, alerts or notifications related to estimated glucose values, according to a Food and Drug Administration database entry posted Oct. 30. The glucose sensor and the app are still available, but Dexcom required users to update the app to a new version. Dexcom began the recall on Aug. 28. The FDA designated the event as a Class 1 recall, the most serious kind. Dexcom sent a notification to customers in September about the software bug, which applies to version 1.15 of the G6 Android app. To use the app, customers must update it to a new version, according to the entry. https://www.medtechdive.com/news/dexcom-recall-g6-cgm-app/804630/ XX https://www.medscape.com/viewarticle/automated-insulin-delivery-boosts-glycemic-control-youth-2025a1000ub3 XX Tidepool partners with smart ring maker OURA.. press release says: to support a groundbreaking dataset intended to be broadly available for diabetes research, with participation limited to individuals who opt in through Tidepool. Tidepool will pair biometric data from Oura Ring – sleep, activity, heart rate, temperature trends, and menstrual cycles – with diabetes device data, including continuous glucose monitors (CGMs) and insulin pumps. The result will provide researchers with an unprecedented dataset to accelerate the development of new clinical guidelines, next-generation diabetes technology, and personalized care models. Recruitment is expected to launch in early 2026 through an IRB-approved study. By opting in to this study, participants consent to sharing their data with Tidepool's Big Data Donation Project, where data is de-identified and, with participant consent, shared with academics, researchers, and industry innovators to accelerate diabetes research. https://aijourn.com/tidepool-collaborates-with-oura-to-advance-inclusive-diabetes-research-through-wearables/ XX Eli Lilly launches two new clinical trials for baricitinib. These phase 3 trials will investigate whether the drug can delay T1D onset or progression and will open for recruitment soon. Baricitinib has the potential to extend the "honeymoon period" of T1D, meaning that it could preserve remaining insulin-producing beta cells earlier in disease progression. More beta cells mean better blood sugar management—and potentially reduced long-term complications. JAK inhibitors, including baricitinib, are already FDA-approved for other autoimmune diseases, such as rheumatoid arthritis, alopecia, and more. JAK signaling pathways are associated with overactive immune responses, so blocking this pathway may turn down the immune response. The phase 2 Breakthrough T1D-funded BANDIT study was key in showing that this drug is safe and effective in T1D. Importantly, baricitinib is a once-daily oral pill—meaning its use is simple and easy. https://www.breakthrought1d.org/news-and-updates/two-new-trials-baricitinib-to-delay-t1d/ XX Insulet is taking diabetes awareness into the workplace. Having found 79% of people with diabetes have faced bias or misunderstanding at work, the medtech giant is rolling out a range of resources intended to trigger changes in how workplaces approach the condition. Lots going on for Diabetes Awareness month.. some notables.. Insulet's "The Day Diabetes Showed up to Work" campaign. based on a survey of almost 10,000 people 79% of people with diabetes have faced bias or misunderstanding at work,. Almost 90% of people with diabetes surveyed reported experiencing barriers at work due to their condition, and more than 40% of people with diabetes and caregivers said they have workplace-related anxiety tied to the metabolic disease. Around one-quarter of respondents reported fears that diabetes could limit opportunities or lead to workplace discrimination and judgment, and a similar proportion of people said they conceal their condition. https://www.fiercepharma.com/marketing/widespread-workplace-challenges-people-diabetes-spark-insulet-campaign XX New directive issued by the Trump administration could mean people seeking visas to live in the U.S. might be rejected if they have certain medical conditions, including diabetes or obesity. The guidance, issued in a cable the State Department sent to embassy and consular officials and examined by KFF Health News, directs visa officers to deem applicants ineligible to enter the U.S. for several new reasons, including age or the likelihood they might rely on public benefits. The guidance says that such people could become a "public charge" — a potential drain on U.S. resources — because of their health issues or age. The cable's language appears at odds with the Foreign Affairs Manual, the State Department's own handbook, which says that visa officers cannot reject an application based on "what if" scenarios, Wheeler said. The guidance directs visa officers to develop "their own thoughts about what could lead to some sort of medical emergency or sort of medical costs in the future," he said. "That's troubling because they're not medically trained, they have no experience in this area, and they shouldn't be making projections based on their own personal knowledge or bias." Immigrants already undergo a medical exam by a physician who's been approved by a U.S. embassy. https://www.npr.org/2025/11/12/nx-s1-5606348/immigrants-visas-health-conditions-trump-guidance XX SAN DIEGO---Nov. 14, 2025—DexCom, Inc. (NASDAQ: DXCM), the global leader in glucose biosensing, today unveiled 16 new diabetes advocates to represent people living with diabetes globally as part of Dexcom's World Diabetes Day campaign. The advocates – ranging from ages six to 68, spanning various types of diabetes, and hailing from four continents and five countries – were selected from 1,000 open call submissions based on their experiences advocating for people with diabetes in their communities. While each person's experience with diabetes is unique, they share a common passion for advocacy – and use of Dexcom's glucose biosensing technology. "Through advocacy, I strive to show others, especially children and newly diagnosed patients, that diabetes is not a limitation but an opportunity to grow stronger, inspire resilience and pursue ambitious goals," said Maria Alejandra Jove Valerio, one of Dexcom's new advocates. "What began as a diagnosis at age seven has grown into a lifelong mission to uplift others." This effort represents the first time Dexcom has sourced voices from the broader diabetes community specifically for its World Diabetes Day campaign, reinforcing Dexcom's history of and commitment to giving real people with diabetes a platform to share their story on a global stage. Through engaging, editorial-style portraits and deeply personal stories, the campaign highlights each advocate's personal experience with diabetes, what misconceptions about diabetes they'd like to dispel and how they want to inspire others with diabetes to discover what they're made of. To prepare for the spotlight, the group of advocates met in Los Angeles for a World Diabetes Day photoshoot which included a surprise visit from Grammy-nominated artist, actor, producer and Dexcom Warrior Lance Bass and author, producer, actress and Stelo*Ambassador Retta. This visit offered the advocates an opportunity to exchange stories and personal perspectives on the meaning of diabetes advocacy and how they live it each day. Behind the lens at the shoot was another member of the diabetes community—photographer Tommy Lundberg who lives with Type 1 diabetes. "Directing this photoshoot was nothing short of inspiring. Each of these advocates has a unique an XX On what would have been the 100th birthday of its visionary founder Alfred E. Mann, MannKind Corporation (Nasdaq: MNKD), in partnership with Alfred E. Mann Charities and The Diabetes Link, announced the launch of the Centennial Al Mann Scholarship. The new program will distribute $100,000 in scholarship funds to support at least 10 young adult students living with diabetes as they pursue higher education in life sciences. Launched in Diabetes Awareness Month, the scholarship program honors Alfred E. Mann's enduring legacy of innovation, philanthropy, and his lifelong commitment to improving the quality of human life through medical advancement. Deeply passionate about giving back, Mr. Mann believed that his success should continue to serve humanity long after his passing, a belief that lives on through this initiative. Each scholarship recipient will be awarded up to $10,000, distributed in annual installments of $2,500 throughout the course of their studies. Depending on the length of their degree program, recipients may receive between two and four installments (up to the full $10,000 per student). The first awards will be made for the 2026 academic year. "Al Mann dedicated his life to helping people with serious medical conditions live longer, healthier lives. This scholarship is a reflection of that spirit," said Michael Castagna, PharmD, Chief Executive Officer of MannKind Corporation. "By supporting students living with diabetes who are pursuing careers in the life sciences and adjacent fields, we're honoring Al's legacy and investing in the future of innovation and care. This program is about giving back to the community we serve and empowering the next generation to carry forward Al's mission of making a meaningful difference in people's lives." Alfred E. Mann Charities and MannKind will partner with The Diabetes Link to launch the program to serve young adults (aged 18-22) living with either type 1 or type 2 diabetes with their higher education goals. Those eligible will include incoming freshmen and current students pursuing 2- or 4-year degrees. The application window will open in early 2026, and for those interested in receiving notifications, an early interest form is available. More information about the scholarship will be shared on thediabeteslink.org. "We're honored to partner with MannKind to expand access to higher education for young adults with diabetes," said Manuel Hernández, Chief Executive Officer of The Diabetes Link. "At a time when the cost of college continues to rise, this scholarship helps ease the financial burden and carries forward the spirit of Al Mann, whose vision and legacy continue to inspire us." Mr. Mann was MannKind's Chairman of the Board from 2001 until his passing in February 2016 and served as Chief Executive Officer from November 2003 until January 2015. Driven by a desire to improve lives and fill unmet medical needs, for more than six decades he founded 17 companies and developed breakthrough medical devices, including insulin pumps, cochlear implants, cardiac pacemakers and retinal prostheses. In 1997, Mr. Mann saw the potential of a dry powder insulin formulation to change the way diabetes is treated and invested nearly $1 billion to help bring Afrezza® (insulin human) Inhalation Powder to market. About MannKind MannKind Corporation (Nasdaq: MNKD) is a biopharmaceutical company dedicated to transforming chronic disease care through innovative, patient-centric solutions. Focused on cardiometabolic and orphan lung diseases, we develop and commercialize treatments that address serious unmet medical needs, including diabetes, pulmonary hypertension, and fluid overload in heart failure and chronic kidney disease. With deep expertise in drug-device combinations, MannKind aims to deliver therapies designed to fit seamlessly into daily life. Learn more at mannkindcorp.com. About Alfred E. Mann Charities, Inc. Alfred E. Mann Charities, Inc. became active in 2016, following the passing of the organization's benefactor, Alfred E. Mann. Throughout his life, Al was passionate about philanthropy and was dedicated to prolonging and improving the quality of human lives through innovation in the fields of healthcare and the use of medical devices. It was important to Al that his success and assets continue to better human lives even after his own passing. Alfred E. Mann Charities, Inc. (formerly known as Alfred E. Mann Family Foundation) has similarly placed its primary focus on healthcare and medical innovation, as our organization believes this is where we can have the greatest impact on humanity and human health throughout the world. Alfred E. Mann Charities, Inc. is also dedicated to promoting arts, culture, education, and community development across Los Angeles and throughout the world in order to best serve people and this planet. Learn more at aemanncharities.org. About The Diabetes Link The Diabetes Link is the only national nonprofit organization dedicated to empowering young adults living with diabetes. Founded by and for young adults, The Link serves this community through peer support, leadership opportunities, and practical, evidence-based resources designed for real life. Its network of campus and community chapters, active online community, and robust Resource Hub help young adults navigate the transitions of early adulthood while managing diabetes. The organization envisions a future where every young adult living with diabetes has
Carotid artery disease management has come a long way. From the days when every stroke meant an endarterectomy to a modern era defined by precision, evidence, and evolving technology. With advances in medical therapy and newer techniques like TCAR, the vascular surgeon has even more to consider when choosing the best treatment for carotid disease. Join us as we break down the major landmark trials NASCET, CREST and the Asymptomatic Carotid trials, and discuss how their findings shape our clinical decisions in practice today. Hosts: · Christian Hadeed -PGY 4 General Surgery, Brookdale Hospital Medical Center · Paul Haser -Division Chief, Vascular Surgery, Brookdale Hospital Medical Center · Andrew Harrington, Vascular surgery, Brookdale Hospital Medical Center · Lucio Flores, Vascular surgery, Brookdale Hospital Medical Center Learning Objectives: · Review the key findings and clinical implications of the NASCET, ACST, and CREST trials. · Discuss patient selection for carotid endarterectomy (CEA) vs carotid artery stenting (CAS). · Understand how age, calcification, and aortic arch anatomy affect stenting outcomes or choice between stent and CEA. · Identify how advances in medical therapy have influenced management of asymptomatic disease. · Discuss appropriate screening/ follow up plans for patients who do not meet criteria for intervention References: - North American Symptomatic Carotid Endarterectomy Trial Collaborators. (1991). Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis. The New England Journal of Medicine, 325(7), 445–453. https://pubmed.ncbi.nlm.nih.gov/1852179/ - Brott, T. G., Hobson, R. W. II, Howard, G., Roubin, G. S., Clark, W. M., Brooks, W., ... & Howard, V. J. (2010). Stenting versus endarterectomy for treatment of carotid-artery stenosis. The New England Journal of Medicine, 363(1), 11–23. https://pubmed.ncbi.nlm.nih.gov/20505173/ - Halliday, A., Mansfield, A., Marro, J., Peto, C., Peto, R., Potter, J., & Thomas, D.; MRC Asymptomatic Carotid Surgery Trial (ACST) Collaborative Group. (2004). Prevention of disabling and fatal strokes by successful carotid endarterectomy in patients without recent neurological symptoms: Randomized controlled trial. The Lancet, 363(9420), 1491–1502. https://pubmed.ncbi.nlm.nih.gov/15135594/ - Halliday, A., Bulbulia, R., Bonati, L. H., Chester, J., Cradduck-Bamford, A., Peto, R., & Pan, H., & the ACST-2 Collaborative Group. (2021). Second asymptomatic carotid surgery trial (ACST-2): A randomised comparison of carotid artery stenting versus carotid endarterectomy. The Lancet, 398(10305), 1065-1073. https://doi.org/10.1016/S0140-6736(21)01910-3 Please visit https://behindtheknife.org to access other high-yield surgical education podcasts, videos and more. If you liked this episode, check out our recent episodes here: https://behindtheknife.org/listen Behind the Knife Premium: General Surgery Oral Board Review Course: https://behindtheknife.org/premium/general-surgery-oral-board-review Trauma Surgery Video Atlas: https://behindtheknife.org/premium/trauma-surgery-video-atlas Dominate Surgery: A High-Yield Guide to Your Surgery Clerkship: https://behindtheknife.org/premium/dominate-surgery-a-high-yield-guide-to-your-surgery-clerkship Dominate Surgery for APPs: A High-Yield Guide to Your Surgery Rotation: https://behindtheknife.org/premium/dominate-surgery-for-apps-a-high-yield-guide-to-your-surgery-rotation Vascular Surgery Oral Board Review Course: https://behindtheknife.org/premium/vascular-surgery-oral-board-audio-review Colorectal Surgery Oral Board Review Course: https://behindtheknife.org/premium/colorectal-surgery-oral-board-audio-review Surgical Oncology Oral Board Review Course: https://behindtheknife.org/premium/surgical-oncology-oral-board-audio-review Cardiothoracic Oral Board Review Course: https://behindtheknife.org/premium/cardiothoracic-surgery-oral-board-audio-review Download our App: Apple App Store: https://apps.apple.com/us/app/behind-the-knife/id1672420049 Android/Google Play: https://play.google.com/store/apps/details?id=com.btk.app&hl=en_US
In this solo episode, Darin reframes one of the most misunderstood forces in life — stress. Instead of seeing it as the enemy, he explores how stress is actually a messenger, guiding you back to alignment, safety, and awareness. Through science, spirituality, and lived experience, Darin breaks down how stress shows us where we're trying to control, where we're disconnected, and where our nervous system is calling for attention. He unpacks the layers of modern stress — from trauma and environment to community and purpose — and offers practical, embodied tools to restore calm, clarity, and resilience. What You'll Learn 00:00:00 – Welcome to Super Life: Solutions for a Healthier Life and Better World 00:00:32 – Sponsor Spotlight: TheraSauna - Natural Healing Technologies (15% off with code Darrandai) 00:02:10 – The Super Life Podcast: Finding Contentment, Happiness, and Purpose 00:02:51 – Today's Topic: Stress - Reframing Stress as an Ally and Dashboard Light 00:04:54 – The "No Choice" Universe: Reconnecting to Infinite Possibilities 00:05:16 – The Reality of Stress: Statistics and the Impact of Chronic Stress 00:06:21 – Stress is Layered: Beyond a Single Cause, Addressing Chronic Stress 00:08:29 – Solutions for a Super Life: Safety over Calm and the Vagal Response 00:09:38 – The Inner Dialogue Layer: Trauma, Unconsciousness, and Spiritual Bypassing 00:11:47 – The Social Field Layer: Relationships, Community, and Finding Your Way Home 00:14:20 – Sponsor Spotlight: Bite Toothpaste - Sustainable, Non-Toxic Tabs (20% off with code Darin20) 00:16:35 – Creating Your Own Vision: Setting Boundaries with Media and Social Algorithms 00:17:29 – Finding Your Purpose: From Raising Children to Healing Injuries 00:18:35 – Environmental and Existential Stress Layers: Clutter, Noise, and Service 00:19:26 – Stress Load and Resiliency: Why Small Triggers Cause Blow-Ups 00:20:02 – Understanding the Dashboard Light: Acknowledging Unwillingness 00:20:35 – Safety as the Signal: Body Relaxation and Providing Inner Security 00:23:44 – Reframing Trauma: Was it the Protector You Needed at the Time? 00:25:00 – Releasing Trauma: Techniques, The Healing Code, and Waking the Tiger 00:26:06 – Finishing the Survival Response: Shaking, Crying, Screaming, and Stretching 00:26:38 – Stress as a Multiplier: Impact on Immune System, Heart, and Aging 00:28:10 – Stress Slows Repair: Inflammation, Cardiovascular Risk, and Cellular Aging 00:29:48 – The Integrative Approach: Changing Your Environments to Support Anti-Stress 00:30:07 – Actionable Stress Solutions: Circadian Rhythm, Nature, and Noise Reduction 00:30:44 – Actionable Stress Solutions: Gratitude, Conscious Breath, and Movement 00:31:32 – Energy Drains to Eliminate: Conflict, Clutter, Scrolling, and Late Caffeine 00:32:17 – Connecting to Greater Purpose: The Super Life Patreon Platform 00:32:54 – Morning/Night Questions: Letting Go, Creating, and Contributing 00:33:17 – Final Toolkit: Slow Breathing, Movement, Nature, Sauna, and Sleep 00:34:25 – The Invitation: Digging into all Layers of a Super Life on Patreon Thank You to Our Sponsors Therasage: Go to www.therasage.com and use code DARIN at checkout for 15% off Bite Toothpaste: Go to trybite.com/DARIN20 or use code DARIN20 for 20% off your first order. Find More from Darin Olien: Instagram: @darinolien Podcast: SuperLife Podcast Website: superlife.com Book: Fatal Conveniences Key Takeaway "Stress isn't your enemy — it's your compass. Every wave of tension points you back to what's asking for care, attention, and love. When you stop fighting stress and start listening to it, you don't just survive — you evolve." Bibliography (selected, peer-reviewed) Sources: Gallup Global Emotions (2024); Gallup U.S. polling (2024); APA Stress in America (2023); Natarajan et al., Lancet Digital Health (2020); Orini et al., UK Biobank (2023); Martinez et al. (2022); Leiden University (2025). Cohen S, Tyrrell DA, Smith AP. Psychological stress and susceptibility to the common cold. N Engl J Med.1991;325(9):606–612. New England Journal of Medicine Cohen S, et al. Chronic stress, glucocorticoid receptor resistance, inflammation, and disease risk. Proc Natl Acad Sci USA. 2012;109(16):5995–5999. PNAS Kiecolt-Glaser JK, et al. Slowing of wound healing by psychological stress. Lancet. 1995;346(8984):1194–1196. The Lancet Kiecolt-Glaser JK, et al. Hostile marital interactions, proinflammatory cytokine production, and wound healing.Arch Gen Psychiatry. 2005;62(12):1377–1384. JAMA Network Tawakol A, et al. Relation between resting amygdalar activity and cardiovascular events. Lancet.2017;389(10071):834–845. The Lancet Epel ES, et al. Accelerated telomere shortening in response to life stress. Proc Natl Acad Sci USA.2004;101(49):17312–17315. PNAS McEwen BS, Stellar E. Stress and the individual: mechanisms leading to disease. Arch Intern Med.1993;153(18):2093–2101. PubMed McEwen BS, Wingfield JC. Allostasis and allostatic load. Ann N Y Acad Sci. 1998;840:33–44. PubMed Felitti VJ, et al. Relationship of childhood abuse and household dysfunction to many leading causes of death in adults (ACE Study). Am J Prev Med. 1998;14(4):245–258. AJP Mon Online Edmondson D, et al. PTSD and cardiovascular disease. Ann Behav Med. 2017;51(3):316–327. PMC Afari N, et al. Psychological trauma and functional somatic syndromes: a systematic review and meta-analysis.Psychosom Med. 2014;76(1):2–11. PMC Goyal M, et al. Meditation programs for psychological stress and well-being: a systematic review and meta-analysis. JAMA Intern Med. 2014;174(3):357–368. PMC Qiu Q, et al. Forest therapy: effects on blood pressure and salivary cortisol—a meta-analysis. Int J Environ Res Public Health. 2022;20(1):458. PMC Laukkanen T, et al. Sauna bathing and reduced fatal CVD and all-cause mortality. JAMA Intern Med.2015;175(4):542–548. JAMA Network Zureigat H, et al. Physical activity lowers CVD risk by reducing stress-related neural activity. J Am Coll Cardiol.2024;83(16):1532–1546. PMC Holt-Lunstad J, Smith TB, Layton JB. Social relationships and mortality risk: a meta-analytic review. PLoS Med.2010;7(7):e1000316. PMC Chen Y-R, Hung K-W. EMDR for PTSD: meta-analysis of RCTs. PLoS One. 2014;9(8):e103676. PLOS Hoppen TH, et al. Network/pairwise meta-analysis of PTSD psychotherapies—TF-CBT highest efficacy overall.Psychol Med. 2023;53(14):6360–6374. PubMed van der Kolk BA, et al. Yoga as an adjunctive treatment for PTSD: RCT. J Clin Psychiatry. 2014;75(6):e559–e565. PubMed Kelly U, et al. Trauma-center trauma-sensitive yoga vs CPT in women veterans: RCT. JAMA Netw Open.2023;6(11):e2342214. JAMA Network Bentley TGK, et al. Breathing practices for stress and anxiety reduction: components that matter. Behav Sci (Basel). 2023;13(9):756.