Podcasts about Molecular medicine

In today's episode, the crew once again dives into the Zebrafish Husbandry Association initiative to make science more easily accessible and reproducible. Ana Borges of the Gulbenkian Institute for Molecular Medicine breaks down the benefits of sharing this information and how it can make the collaborative scientific community even better! The more data we collect and report, the easier it is to draw strong scientific conclusions. Enjoy!This podcast is brought to you by the Jack Dempsey Cichlid (Rocio octofasciata). Named after the famous boxer, these fish are not to be reckoned with. Neighborhood fishes have been known to cross the street when they see this marvel coming. In the early 2000s, they were discovered in Australia and despite human attempts to eradicate them as an invasive species, the fish donned boxing gloves and sent those humans packing. Cheers to you Jack Dempsey, the man, not the fish. Thanks for listening to Gettin' Fishy With It! You can find our new website at ⁠⁠⁠⁠www.gettinfishywithit.com⁠⁠⁠⁠. You can find us on Bluesky at ⁠⁠⁠⁠@gettinfishypod.bsky.social⁠⁠⁠⁠ and on Instagram⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ @gettingfishypod⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. You can also find us on ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Facebook⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ and⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠LinkedIn⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. If you want to drop us an email, you can send your complaints (or questions!) to gettingfishypod@gmail.com.Our theme music is “Best Time” by⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ FASSOUNDS⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Our audio is edited by Amber Park Chiodini. Amber has her own podcast all about movies, called⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ So What Happens Next?⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠We very much appreciate you taking the time to listen to our fifty-fifth episode! Please help out the podcast by subscribing on your podcast platform of choice. If you could leave us a review, that would be super helpful!If you would like to support the show, you can sign up as a paid member on our⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Substack⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠, or you can ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠buy us a coffee⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠!Thanks and we'll “sea” you again in two weeks!

NTNU professor Marit Otterlei nearly threw out the contaminated cell culture where she and her colleagues were testing a new cancer drug.The problem arose on a hot summer day, in Trondheim, in a country not known for hot summer days. So they'd opened the lab's windows overnight.When they came back the next day, they found an uninvited guest, snuggled in with their cancer cell culture: Bacteria!!!Here's the thing, though: although the drug had been designed to work on human cancer cells, it looked like it had killed the bacteria, too!That was remarkable, because the cancer drug targeted a specific mechanism that human cells use to replicate. It looked like the drug also targeted the same mechanism in bacteria -- even though the tree of life had branched away from bacteria 3 BILLION years ago! How could that be?Today's podcast takes a peek into the challenging world of what it takes to bring a drug, especially an antibiotic, to market. But it's also an inside look into how some researchers, with their deep curiosity about the nuts and bolts of how life actually works, can come up with startling discoveries that may someday save our lives. Sometimes, the key to saving lives can be hidden in a protein that hasn't changed much over billions of years.Our guests on today's show are Marit Otterlei, a professor at NTNU's Department of Clinical and Molecular Medicine; Siril Skaret Bakke, innovation manager at NTNU's Technology Transfer Office AS, and Christine Årdal , senior researcher at the Norwegian Institute of Public Health.Marit is a part-time CSO at APIM Therapeutics (https://www.apimtherapeutics.com/), which is developing the cancer drug that she was testing back in 2011, when an open window on a hot summer day led her to suspect that her substance might a possible antibiotic, too. That antibiotic, Betatide, is now undergoing testing that pharmaceutical companies require before investing in it.Here's a list of some of the key academic publications:Gilljam, Karin Margaretha; Feyzi, Emadoldin; Aas, Per Arne; Sousa, Mirta; Müller, Rebekka; Vågbø, Cathrine Broberg. (2009) Identification of a novel, widespread, and functionally important PCNA-binding motif. Journal of Cell BiologyNedal, Aina; Ræder, Synnøve Brandt; Dalhus, Bjørn; Helgesen, Emily; Forstrøm, Rune Johansen; Lindland, Kim. (2020) Peptides containing the PCNA interacting motif APIM bind to the beta-clamp and inhibit bacterial growth and mutagenesis. Nucleic Acids Research (NAR)Nepal, Anala; Ræder, Synnøve Brandt; Søgaard, Caroline Krogh; Haugan, Maria Schei; Otterlei, Marit. (2021) Broad-Spectrum Antibacterial Peptide Kills Extracellular and Intracellular Bacteria Without Affecting Epithelialization. Frontiers in Microbiology Hosted on Acast. See acast.com/privacy for more information.

Amy MacIver is joined by Professor Elizabeth Mayne, a specialist haematologist and immunopathologist at the University of Cape Town, to unpack new research revealing how our immune system is influenced by light. A recent study from the University of Auckland found that neutrophils — the body’s most abundant white blood cells — are more effective at killing bacteria during the day, thanks to an internal, light-sensitive circadian clock. Presenter John Maytham is an actor and author-turned-talk radio veteran and seasoned journalist. His show serves a round-up of local and international news coupled with the latest in business, sport, traffic and weather. The host’s eclectic interests mean the program often surprises the audience with intriguing book reviews and inspiring interviews profiling artists. A daily highlight is Rapid Fire, just after 5:30pm. CapeTalk fans call in, to stump the presenter with their general knowledge questions. Another firm favourite is the humorous Thursday crossing with award-winning journalist Rebecca Davis, called “Plan B”. Thank you for listening to a podcast from Afternoon Drive with John Maytham Listen live on Primedia+ weekdays from 15:00 and 18:00 (SA Time) to Afternoon Drive with John Maytham broadcast on CapeTalk https://buff.ly/NnFM3Nk For more from the show go to https://buff.ly/BSFy4Cn or find all the catch-up podcasts here https://buff.ly/n8nWt4x Subscribe to the CapeTalk Daily and Weekly Newsletters https://buff.ly/sbvVZD5 Follow us on social media: CapeTalk on Facebook: https://www.facebook.com/CapeTalk CapeTalk on TikTok: https://www.tiktok.com/@capetalk CapeTalk on Instagram: https://www.instagram.com/ CapeTalk on X: https://x.com/CapeTalk CapeTalk on YouTube: https://www.youtube.com/@CapeTalk567 See omnystudio.com/listener for privacy information.

Researchers at the University of Pretoria have identified the gene that is responsible for diet-related obesity. By exploring the role of the novel gene, they have made a potential breakthrough in current knowledge about the cellular mechanisms that drive fat accumulation. For more Bongiwe Zwane spoke to Prof. Melvin Ambele of the University of Pretoria's Institute for Cellular and Molecular Medicine

Scientific Sense ® by Gill Eapen: Prof. Kevin Tracey is Professor of Molecular Medicine and Neurosurgery at Hofstra/Northwell. He is also the CEO of Feinstein Institutes for Medical Research. His latest book is Great Nerve. Please subscribe to this channel:https://www.youtube.com/c/ScientificSense?sub_confirmation=1

In this #episode of the Longevity & Aging Series, Dr. Stephen Vatner from the Department of Cell Biology and Molecular Medicine at Rutgers New Jersey Medical School, joins host Dr. Evgeniy Galimov to discuss a #research perspective he co-authored in Volume 16, Issue 22 of Aging (Aging-US), titled “Brown adipose tissue enhances exercise performance and healthful longevity.” DOI - https://doi.org/10.18632/aging.206179 Corresponding author - Stephen F. Vatner - vatnersf@njms.rutgers.edu Author interview - https://www.youtube.com/watch?v=-DE4H2DtSZg Video short - https://www.youtube.com/watch?v=n1DvuR7owJQ Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206179 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, brown adipose tissue, white adipose tissue, healthful longevity, exercise, regulator of G protein signaling 14 To learn more about Aging (Aging-US), please visit our website at https://www.Aging-US.com​​ and connect with us on social media at: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Join us on the Best Health podcast as host Carrie Lee Astwood interviews Dr. Carika Weldon, founder of CariGenetics. Discover the transformative power of genetic testing and its impact on personalized healthcare. Dr. Weldon shares insights on her DNA kits, the importance of genetic testing, and how understanding our genetics can enhance mental and physicalperformance.   Dr Carika Weldon, PhD, MRSB, FIBMS (Founder, CEO, and Director of Research) is a Bermudian biochemist and the first sole black female founder of a genomics company in the world. She received her Bachelor of Science honours degree in Medical Biochemistry from the University of Leicester, then went on to complete her Doctor of Philosophy in Biochemistry at the same university. In 2015, Dr Weldon became the youngest full-time Lecturer in Biomedical and Medical Sciences at De Montfort University in the UK. In 2016, Dr Weldon founded the Bermuda Principles Foundation (BPF), to make a worthwhile contribution to Bermudian society in both the education and science tourism sectors. In November 2018, Dr Weldon returned to full-time research, working as a Research Scientist within the Oxford Genomics Centre at the University of Oxford. In April 2020, called by the Bermuda Government, Dr Weldon returned to Bermuda to expand testing capacity for COVID-19 and was appointed as Science Advisor to the Premier for COVID-19 and Laboratory Director of the government's Molecular Diagnostic Laboratory, which she created. Dr Weldon was granted a Queen's Certificate & Badge of Honour in November 2020. Currently, Dr Weldon is an adjunct lecturer at the Bermuda College, teaching Molecular Medicine, along with her current role at CariGenetics. She is focused on ensuring the research culture the pandemic fostered amongst healthcare professionals and the general public is harnessed for a healthier future for Bermuda.    Sponsor: Lindo's

How researchers are creating non-hallucinogenic psychedelics Guest: Dr. David Olson, Professor in the Department of Biochemistry and Molecular Medicine at UC Davis, Director of the UC Davis Institute for Psychedelics and Neurotherapeutics, and Co-founder and Chief Innovation Officer at Delix Therapeutics Learn more about your ad choices. Visit megaphone.fm/adchoices

Have scientists discovered evidence of string theory? Guest: Michael Kavic, Professor of Chemistry and Physics at the State University of New York at Old Westbury and Co-Author of the Study Weekly Cecchini Check-In for Apr 11, 2025 Guest: Reggie Cecchini, Washington Correspondent for Global News How researchers are creating non-hallucinogenic psychedelics Guest: Dr. David Olson, Professor in the Department of Biochemistry and Molecular Medicine at UC Davis, Director of the UC Davis Institute for Psychedelics and Neurotherapeutics, and Co-founder and Chief Innovation Officer at Delix Therapeutics Why is BC urging the government to scrap US contracts? Guest: Ravi Kahlon, Minister of Housing and Municipal Affairs, and Chair of BC's Tariff Response Committee Kickin It with the Caps for Apr 11, 2025 Guest: Jesper Sørensen, Head Coach of the Vancouver Whitecaps Who should be the MP for Richmond East—Steveston? Guest: Parm Bains, Liberal Candidate for Richmond East—Steveston Guest: Keefer Pelech, NDP Candidate for Richmond East—Steveston Guest: Zach Segal, Conservative Candidate for Richmond East—Steveston Learn more about your ad choices. Visit megaphone.fm/adchoices

Denis DubouleCollège de FranceÉvolution du développement et des génomesAnnée 2024-2025Enhancers Sequences and Gene RegulationColloque - Ana Pombo : Variations in 3D Genome Structure Between Cell Types and in Stimulus ResponsesAna PomboMax-Delbrück-Centrum for Molecular Medicine, Berlin, Germany

Dr. Hoffman continues his conversation with Dr. Garth Nicolson, Founder, President, Chief Scientific Officer, and Emeritus Research Professor of Molecular Pathology at the Institute for Molecular Medicine in Huntington Beach, California, and Research Advisor for Nutritional Therapeutics, makers of NTFactor.

Danielle studies triple-negative breast cancer (TNBC), an aggressive breast cancer subtype associated with poor survival. Unlike other subtypes for which there are targeted therapies, treatment options for TNBC are limited. In order to better understand the biology underlying TNBC, she studies a family of proteins called calpains. For upcoming interviews check out the Grad Chat webpage on Queen’s University School of Graduate Studies & Postdoctoral Affairs website.

KeywordsCervical Cancer, ASCCP Guidelines, HPV Testing, Self-Collection, At-Home Testing, Women's Health, Diagnostic Solutions, Preventive Care, Medical Technology, Health AccessSummaryIn this episode of Clinical Lab Chat, Chris Wolski and Dr. Jeff Andrews discuss significant advancements in cervical cancer prevention, focusing on the new ASCCP guidelines, the role of technology in screening, and the importance of self-collection methods. They explore how these changes can improve access to care for women and the future of at-home testing, while also addressing the psychological barriers and stigmas associated with cervical cancer screening.TakeawaysThe ASCCP guidelines are essential for managing cervical cancer risk.Technology has transformed how guidelines are updated and accessed.Self-collection methods can significantly increase screening rates.At-home testing is preferred by many women for convenience and privacy.Addressing stigmas is crucial for increasing testing participation.Cervical cancer is highly treatable when detected early.The Onclarity assay provides extended genotyping for better risk assessment.Guidelines are now more dynamic and can be updated quickly.Improving access to care is vital for women's health.The fight against cervical cancer is entering an exciting new phase.TitlesRevolutionizing Cervical Cancer PreventionThe Future of Women's Health ScreeningSound Bites"We can update guidelines very quickly now.""The app makes it much more dynamic and useful.""We're dealing with a couple of stigmas."Chapters00:00Introduction to New Diagnostic Guidelines02:51Understanding ASCCP Guidelines and Their Evolution05:30The Role of Technology in Women's Health Testing08:11Onclarity HPV Assay and Its Significance10:48Self-Collection Methods for Cervical Cancer Screening13:19The Future of At-Home Testing15:53Impact of New Guidelines on Labs and Testing18:32Addressing Stigmas and Psychological Barriers20:45Conclusion and Future Directions21:41Podcast Music Outro.wav

Send us a textDr. Dimitris Tsoukalas MD, PhD is a Board-Certified Family Physician, the Scientific Director of the Metabolomic Medicine® Medical Group, President of European Institute of Molecular Medicine, and an Associate Member of the World Academy of Sciences.Dr. Dimitris Tsoukalas is a medical doctor and scientific director of Metabolomic Medicine® medical group, with clinics in Athens Greece and , Milan Italy. He is a pioneer in the prevention and treatment of autoimmune and chronic conditions such as Hashimoto's thyroiditis, rheumatoid arthritis, diabetes, systemic lupus erythematosus, multiple sclerosis, psoriasis, Crohn's disease, and ulcerative colitis, using Metabolomic Analysis®.Metabolomic Analysis® detects deficiencies in micronutrients and the metabolic causes of autoimmune and chronic diseases. He is also the author of the best-selling book How to Live 150 Years in Health.He has published more than 50 scientific studies and is a keynote speaker at international medical conferences for the detection of metabolic disorders and micronutrient deficiencies related to preventing and treating autoimmune and chronic diseases.Find Dr. Tsoukalas at-https://www.drtsoukalas.com/Find Boundless Body at- myboundlessbody.com Book a session with us here!

This week we welcome Michael Metoudi, RD, M.Sc, a registered dietitian working within both research and clinical practice. Michael talks about his research on the knowledge and views held by registered dietitians in England and Northern Ireland on plant-based diets.Michael holds a master in Molecular Medicine and has previously worked in clinical trials for immunotherapy-related cancer treatments at King's College London.During this time he found himself exposed to the emerging research into plant-based nutrition and the many benefits it can have in terms of human health. Attending the first PBHP conference in 2018 inspired him into to redirect the course of his career path into clinical nutrition.Having obtained a masters in clinical nutrition and dietetics from University College Dublin, Michael now works in nutrition research as well as in clinic with clients of all ages, and within an eating disorders recovery centre.Michael's published paper discussed:https://onlinelibrary.wiley.com/doi/10.1111/jhn.13386Link to the binge eating disorder factsheet: https://plantbasedhealthprofessionals.com/wp-content/uploads/2025/02/BingeEatingDisorder-250221.pdfLink to the newly published position statement from the Academy of Nutrition and Dietetics:https://pubmed.ncbi.nlm.nih.gov/39923894/

「温かいを感じる専用の神経細胞はなかった」 独研究者が2020年に発表したマウスの“温度知覚メカニズム”を紹介。　ドイツのMax Delbruck Center for Molecular Medicineなどに所属する研究者らが2020年に発表した論文「The Sensory Coding of Warm Perception」は、哺乳類における温感知覚のメカニズムを発見した研究報告である。

Take a virtual coffee break today with the Medical College of Wisconsin and the Advancing a Healthier Wisconsin Endowment as we chat with Srividya (Vidya) Kidambi, MD, MS, Chief of Division of Endocrinology and Molecular Medicine and Professor of Medicine at the Medical College of Wisconsin, about the body's physiological adaptations to a fasted state or calorie restriction and the implications for successful weight loss.

In this episode of Peak Human Labs, Dr. Sanjeev Goel sits down with Dr. Ryan Rossner, a former NFL player turned PhD researcher, now working at MiniCircle—a pioneering company developing the world's first reversible human genetic enhancement platform. Using highly expressive DNA plasmids, MiniCircle's innovative approach allows genes to be added to the body without altering the existing genome.   Dr. Rossner delves into groundbreaking health optimization strategies, particularly gene therapy involving the follistatin gene, which enhances muscle growth, reduces inflammation, and supports rejuvenation. The conversation expands to other gene therapies, the role of sleep and exercise in longevity, and the importance of a holistic approach to health.   They also explore cutting-edge longevity science, including hibernation's impact on metabolism, metabolic flexibility, and seasonal metabolic shifts. Dr. Rossner introduces the concept of metabolic elasticity—how an adaptable metabolism can extend lifespan. He breaks down key longevity mechanisms such as fasting, insulin regulation, and AMPK activation while highlighting promising research areas like ICAR and plasmapheresis. Throughout the discussion, he shares insights from his work at MiniCircle, offering a glimpse into the future of health and longevity interventions.   Ready to dive deeper into the latest breakthroughs in longevity and health optimization? Subscribe now, share this episode with a friend, and stay tuned for more expert insights on Peak Human Labs! Key Takeaways Longevity and health optimization Gene therapy and its mechanisms Follistatin gene therapy for body composition and rejuvenation Accessibility and cost of gene therapy treatments Benefits of increased follistatin levels, including muscle growth and reduced inflammation Lifestyle factors contributing to longevity, such as sleep, exercise, and relationships Importance of self-monitoring and health-tracking tools Role of sleep in overall health and longevity In This Episode: [00:00:00] Introduction to the podcast [00:01:17] Guest introduction – Dr. Ryan Rossner [00:03:00] Mini Circle overview [00:03:37] Follistatin gene benefits [00:04:05] Gene therapy mechanism [00:04:57] Transfection process [00:05:22] DNA integration clarification [00:05:58] Follistatin level variation [00:06:44] Therapy duration [00:07:06] Accessibility of treatment [00:07:42] Future gene therapies [00:08:09] Clotho gene benefits [00:08:47] Patient treatment outcomes [00:09:30] Biological age measurement [00:09:43] Age reduction results [00:10:19] Personal experience in longevity [00:11:46] Pyramid of longevity [00:12:02] Individual variation in treatment response [00:12:18] Importance of sleep [00:13:10] Sleep and detoxification [00:13:44] Orexin receptor antagonists [00:14:20] Impact of aging on sleep [00:16:28] Weekly exercise routine [00:17:07] Recovery practices [00:20:59] Brain health insights [00:21:33] Supplements for brain health [00:21:52] Sauna and brain health [00:22:31] Hypoxia chamber experience [00:23:31] Research on hypoxia and longevity [00:24:47] Comparing oxygen levels [00:25:13] Creatine for brain benefits [00:26:01] Vitamin D and health [00:26:57] Rapamycin in longevity [00:27:48] Episodic use of rapamycin [00:30:17] Metabolic depression and triggers [00:31:64] Metabolic elasticity [00:34:03] Seasonal metabolism [00:35:06] Underappreciated longevity mechanisms [00:35:21] Genetic pathways and longevity [00:37:03] Interest in plasmapheresis [00:38:04] Future work at Mini Circle [00:38:38] Resources for learning   Our Guest Ryan Rossner is a Ph.D. student in Molecular Medicine at the University of Washington, researching flavin-containing monooxygenase proteins in aging. Dr. Matt Kaeberlein, studies mechanisms of longevity and is a trainee in the Biological Mechanisms of Healthy Aging Program. As Director of Longevity Research at MiniCircle, he develops gene therapy platforms for health optimization. An active biohacker, he experiments with tools like altitude generators and ice baths. Rossner shares insights on aging and longevity through social media, contributing to the broader conversation on extending human potential. Resources and Links Peak Human Labs https://www.youtube.com/@peakhumanlabs/videos https://www.peakhuman.ca/ https://www.instagram.com/peakhumanlabs/?hl=en https://open.spotify.com/show/5hx9R37ElxgzCrBccRWoHd?si=8atK0n82QbeL3DWg5-vjvg&nd=1&dlsi=ce0f77aa4f304724   Dr. Sanjeev Goel https://www.linkedin.com/in/sanjeevgoelmd/?originalSubdomain=ca   Dr. Ryan Rossner   https://minicircle.io https://www.instagram.com/rjrphd/  

Between 5-10% of breast and 20-25% of ovarian cancers are inherited. The majority of hereditary breast and ovarian cancer cases are caused by deleterious mutations (variants) in the BRCA1 and BRCA2 genes, which normally prevent cancer through protecting and repairing our DNA. Genetic testing is used to identify pathogenic BRCA carriers who would subsequently benefit from personalized screening, preventative and management plans. However, its widespread implementation has resulted in a significant increase in findings of variants of uncertain significance (VUS) – DNA sequence variants with uncertain effects on disease risk. VUSs pose a critical clinical challenge as they limit clinicians' ability to effectively interpret genetic test results. For upcoming interviews check out the Grad Chat webpage on Queen’s University School of Graduate Studies & Postdoctoral Affairs website.

A special episode with a unique message of hope. The sport of volleyball is the carrier for the Side-Out Foundation's mission to end breast cancer. On the frontlines of that mission is Dr. Emmanuel Chip Petricoin. He's a pioneering researcher in personalized medicine, and Co-Director of the Center of Applied Proteomics and Molecular Medicine at George Mason University. Hear how his work with the Side-Out Foundation is helping transform how we treat breast cancer.Links mentioned: For more information go to www.side-out.org. Follow the side-out organization on Instagram: https://www.instagram.com/sideoutfndn/Have suggestions for the podcast? Email Janice: leaveitbetter@side-out.org

BUFFALO, NY- December 19, 2024 – We are pleased to announce that Dr. Marco Demaria, a leading expert in aging and cellular senescence, will join Aging (Aging-US) as Editor-in-Chief, starting January 1, 2025. Dr. Demaria will work alongside an esteemed Editorial Board. Dr. Demaria has an impressive background in aging research. He earned his PhD in Molecular Medicine from the University of Torino, Italy. In 2010, he joined the laboratory of Aging Founding Editor, the late Dr. Judith Campisi, at the Buck Institute for Research on Aging. There he developed cellular and animal models for studying cellular aging, also known as cellular senescence, and its role in tissue repair, cancer, and aging. Currently, Dr. Demaria leads DemariaLab, whose mission is “to extend human healthspan by pioneering discoveries in molecular and cellular mechanisms that regulate the aging process.” His groundbreaking research has significantly advanced our understanding of cellular senescence and its role in aging and age-related diseases. Dr. Demaria aims to develop new therapeutic approaches to create more effective treatments that mitigate the diseases and extend the healthspan. His work specifically focuses on interfering with the mechanisms of cellular senescence using genetic, pharmacological, and nutraceutical strategies. “My research is focused on understanding the molecular basis of age-related dysfunctions and disorders, and to identify new molecular and cellular targets to improve health and longevity.” - Marco Demaria He is also a Full Professor at the European Research Institute for the Biology of Ageing (ERIBA), Director of the Mechanisms of Health, Ageing and Disease (MoHAD) at the University Medical Center Groningen (UMCG), President of the International Cell Senescence Association (ICSA), and Co-Founder of Cleara Biotech. Dr. Demaria also brings valuable editorial experience from his former positions as Editor-in-Chief of npj Aging and Editorial Board member of Aging Cell. All the above, combined with Dr. Demaria's academic contributions, commitment, and expertise, align perfectly with Aging's mission to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population. For more information about Marco Demaria, PhD, please visit www.demarialab.com and follow him on X (Twitter) @marc_dema or on Bluesky @marcdema.bsky.social. About Aging-US Please visit our website at https://www.Aging-US.com​​ and connect with us on social media at: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Why red tape is not to blame for mining barriers in BC Guest: Rosemary Collard, Associate Professor of Geography at Simon Fraser University Could bird flu become a human pandemic? Guest: Dr. James Paulson, Chair of Chemistry in the Department of Molecular Medicine at Scripps Research Inside the Russian political influence campaign in Canada Guest: Jen St. Denis, Reporter with The Tyee The Weekly Cecchini Check-In for Dec 13, 2024 Guest: Reggie Cecchini, Washington Correspondent for Global News Learn more about your ad choices. Visit megaphone.fm/adchoices

Guest: Dr. James Paulson, Chair of Chemistry in the Department of Molecular Medicine at Scripps Research Learn more about your ad choices. Visit megaphone.fm/adchoices

Edição de 07 de Dezembro 2024

On December 5, 2024 we spoke with Jason Chen about G-protein signaling in the mammalian photoreceptors, and the G-protein regulator proteins that govern the speed of transduction and the temporal resolution of vision. Guest: Jason Chen, Professor in the Departments of Molecular Medicine and Ophthalmology, and Joe R. and Teresa Lozano Long Chair in Retinal Signaling at UT Health San Antonio. Participating: Erika Tatiana Camacho, Departments of Mathematics and Neuroscience, Developmental and Regenerative Biology, UTSA Host: Charles Wilson, Department of Neuroscience, Developmental and Regenerative Biology, UTSA Thanks to James Tepper for original music

Hemophilia A (HA) is an X-linked bleeding disorder caused by a mutation in the factor 8 (F8) gene that codes for FVIII coagulation protein. FVIII is naturally synthesized in the liver and the mutation results in the loss of function of FVIII protein which is critical in the blood clotting cascades. HA occurs is 1 to 5000 male births and it is estimated that there are a total of 3000 patients with HA in Canada. Currently, HA patients are treated with replacement therapy of the deficient factor. However, this approach is transient because of the short half-life of recombinant or plasma derived FVIII and is insufficient due to the formation of anti-drug antibodies. The alternative approach which is curative and promises a long-lasting expression of FVIII protein is gene therapy. For upcoming interviews check out the Grad Chat webpage on Queen’s University School of Graduate Studies & Postdoctoral Affairs website .

In the fifth Season of the National Institute of Neurological Disorders and Stroke's Building Up the Nerve podcast, we help you strengthen your science communication skills with tools and advice to use throughout your career. We know that navigating your career can be daunting, but we're here to help—it's our job!In the fifth episode of the season, we talk about Securing Funding for Research focusing on choosing what funding to apply for, “pitching” your science to different funders, and writing effective grant applications.Featuring Sonya Dumanis, PhD, Executive Vice President of the Coalition for Aligning Science and Deputy Director for Aligning Science Across Parkinson's; Kat M. Steele, PhD, Associate Director of CREATE and Albert Kobayashi Professor in Mechanical Engineering at University of Washington; and Gene Yeo, PhD, MBA, Professor of Cellular and Molecular Medicine at University of California, San Diego and Chief Scientific Advisor, Sanford Laboratories for Innovative Medicine.ResourcesNIH Funding OpportunitiesSmall Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) grants: https://seed.nih.gov/small-business-funding/small-business-program-basics/understanding-sbir-sttr NINDS Funding Opportunities: https://www.ninds.nih.gov/funding/find-funding-opportunities NINDS Training & Career Development Opportunities: https://www.ninds.nih.gov/funding/training-career-development NIH ResourcesEarly Career Reviewer program: https://public.csr.nih.gov/ForReviewers/BecomeAReviewer/ECR NIH RePORTER: https://reporter.nih.gov/ Early Stage Investigator (ESI) Policies: https://grants.nih.gov/policy-and-compliance/policy-topics/early-stage-investigators NINDS Guidelines for incorporating rigor into grant applications: https://www.ninds.nih.gov/funding/preparing-your-application/preparing-research-plan/rigorous-study-design-and-transparent-reporting NIH Activity Codes: https://grants.nih.gov/funding/activity-codes Allen Institute's Allen Distinguished Investigators: https://alleninstitute.org/division/frontiers-group/distinguished-investigators/ Advanced Research Projects Agency for Health (ARPA-H): https://arpa-h.gov/ Aligning Science Across Parkinson's (ASAP) Disease – Collaborative Research Network (CRN): https://parkinsonsroadmap.org/research-network/# California Institute for Regenerative Medicine (CIRM) grants: https://www.cirm.ca.gov/ Transcript available at http://ninds.buzzsprout.com/.

As part of the US HUPO sponsored "What is a proteomics?" series, Ben and Ben sit down to talk with Dr. Ilaria Piazza, Max Delbrück Center for Molecular Medicine.

Professor Ahmed Ahmed, director of the ovarian cancer cell laboratory at MRC Weatherall Institute of Molecular Medicine at the University of Oxford, is leading the research into the first ovarian cancer vaccine. The hope is that the jab could one day be given to women preventatively on the NHS with the aim of eliminating the disease.Tech & Science Daily speak to the creator of a device helping people with Parkinson's to walk.Martijn van der Ent, Medical Director and co-founder of Cue2Walk International, explains how they created the sensor worn on the leg that detects movements and automatically triggers a rhythmic signal.Also in this episode:Google introduces new way to search by filming videoTikTok influencer 'Mr Prada' arrested for second degree murderNearly £22 billion pledged for UK carbon capture projectsHas Nessie been found? Loch Ness skipper shares pictures of monster-like shape caught on sonar Hosted on Acast. See acast.com/privacy for more information.

In this episode of Critical Matters, Dr. Zanotti discusses the use of intravenous albumin in critical care. He is joined by D. Jeannie Callum, Director of Transfusion Medicine and Professor of Pathology and Molecular Medicine at Queens University in Ontario, Canada. Dr. Callum's research focuses on blood utilization, hemostasis in the bleeding patient, and transfusion-related errors. She has received numerous awards and published extensively. Dr. Callum is the lead author of “Use of Intravenous Albumin: A Guidelines from the International Collaboration for Transfusion Medicine Guidelines,” published earlier this year in CHEST. Additional Resources: Use of Intravenous Albumin. A Guideline from the International Collaboration for Transfusion Medicine Guidelines. CHEST 2024: https://journal.chestnet.org/article/S0012-3692(24)00285-X/fulltext International Collaboration for Transfusion Medicine Guidelines Website: https://www.ictmg.org/ Ten myths about albumin. M Joannidis, et al. Intensive Care Med 2022: https://pubmed.ncbi.nlm.nih.gov/35247060/ A comparison of albumin and saline for fluid resuscitation in the intensive care unit. SAFE Study Investigators. N Engl J Med 2004: https://pubmed.ncbi.nlm.nih.gov/15163774/ Albumin Replacement in Patients with Severe Sepsis or Septic Shock. ALBIOS Study Investigators. N Engl J .Med 2014: https://www.nejm.org/doi/full/10.1056/NEJMoa1305727 Books mentioned in this episode: Ending Medical Reversal: Improving Outcomes, Saving Lives. By Vinayak K. Prasad: https://bit.ly/4dAimRa The Time Machine. By H.G. Wells: https://amzn.to/4eK4apG

References Experimental & Molecular Medicine.2016. volume 48, 224 Nature Metabolism 2023. volume 5, pages 277–293 Nature Reviews Drug Discovery 2019. v18. : 527–551 Pisendal . JG. 1730's. Violin Concerti. https://open.spotify.com/album/6dC3dq8i6rDeeKtz5LyhFZ?si=jUsRMIraR7-zO5o0UQGMdw --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support

Speakers' Profiles Vanessa Fairhurst (she/her) – Head of Community, PREreview ORCID ID: ⁠0000-0001-8511-8689⁠ Vanessa joined the PREreview team in November 2022. She studied her undergraduate degree in European Languages and Business Management before going on to study her Master's in Applied and Professional Ethics. Chad Sansing (he/him) –  Head of Product, PREreview ORCID ID: ⁠0000-0002-1472-1824⁠ Chad joined the PREreview team in late October 2022. Prior to joining PREreview, he worked for the Mozilla Foundation in a variety of roles, most recently as a program manager on the MozFest team. Dine Roseline Dzekem, Founder, Rwanda Preprint Club ORCID ID: ⁠0000-0002-8210-9258⁠ Miss Dine Roseline Dzekem is a public health professional and social scientist in her early career. She has a background in sociology and anthropology from the University of Buea-Cameroon (2016) and a Master's degree in public health from the University of Rwanda (2019). Lamis Yahia Mohamed Elkheir, Lecturer at the University of Khartoum and a Co-Director of the African Reproducibility Network (AREN). ORCID ID: 0000-0002-3516-334X Lamis Yahia Mohamed Elkheir is a Lecturer at the University of Khartoum and a Co-Director of the African Reproducibility Network (AREN). Currently finalizing her PhD in Medicinal Chemistry, Lamis also holds a Master of Science in Molecular Medicine and a Bachelor of Pharmacy. Ebuka Ezeike, Project Manager,  Access 2 Perspectives and  AfricArXiv ORCID ID: 0000-0003-3452-0306 Ebuka Ezeike is a physicist from the Federal University of Technology Minna, in Niger state, Nigeria. With a background in physics and over half a decade of experience as an educator in the field, Ebuka brings a wealth of knowledge to his endeavors. His expertise extends to freelance work, where he delivers writing services, including articles and blog posts. Additionally, he manages two academic podcast shows refining audio and video content, including transcriptions. #openaccess #research #openscience #preprint #peerreview Find more podcast episodes here: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://access2perspectives.pubpub.org/podcast⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Host:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Dr Jo Havemann⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠, ORCID iD ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠0000-0002-6157-1494 ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Editing: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Ebuka Ezeike⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Music:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Alex Lustig⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠, produced by⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Kitty Kat ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ License:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Attribution 4.0 International (CC BY 4.0)   ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ At Access 2 Perspectives, we guide you in your complete research workflow toward state-of-the-art research practices and in full compliance with funding and publishing requirements. Leverage your research projects to higher efficiency and increased collaboration opportunities while fostering your explorative spirit and joy. Website: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://access2perspectives.pubpub.org⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

Dr. Sue Yom, Editor in Chief, hosts Ms. Nina Levin, a Medical Physicist and PhD Candidate and Dr. Bjørn Grønberg, Professor and Consultant in medical oncology and radiotherapy, from the Department of Clinical and Molecular Medicine at the Norwegian University of Science and Technology, and Dr. Megan Daly, Professor from the University of California Davis and an Associate Editor at our journal. We discuss Ms. Levin's and Dr. Grønberg's article, Evaluation of radiotherapy treatment plans in a randomized phase II trial comparing two schedules of twice-daily thoracic radiotherapy in limited stage small-cell lung cancer, and its accompanying editorial, Toward the Optimal Delivery of Twice-Daily Thoracic Chemoradiation in Limited-Stage Small Cell Lung Cancer, as well as an article from the August 2024 issue, Long-Term Outcomes After Concurrent Once- or Twice-Daily Chemoradiation in Limited-Stage Small Cell Lung Cancer: A Brief Report From the CONVERT Trial.

Public Health Careers podcast episode with Tarjani Vaidya, MPH, MS

Host: Denise M. Dupras, M.D., Ph.D. Guest: Margot A. Cousin, Ph.D. This episode of Genes & Your Health provides a comprehensive look at how ASO (Antisense Oligonucleotide) therapy is paving the way for personalized medicine and offering new hope for patients with previously untreatable conditions. Margot A. Cousin, Ph.D., an Assistant Professor of Medical Genetics in the Department of Molecular Medicine and Director of the N-or-1 Therapeutics Program in the Center for Individualized Medicine, walks us through an overview of what antisense oligonucleotides are and how they work.  We then discuss clinical applications, success stories, and potential new applications to transform treatment approaches.  Connect with the Mayo Clinic's School of Continuous Professional Development online at https://ce.mayo.edu/ or on Twitter @MayoMedEd. 

I am delighted to connect with Dr. Nathan Bryan, an international leader in Molecular Medicine, biochemistry, and nitric oxide today. He was the first ever to describe nitrites and nitrates as indispensable nutrients for cardiovascular health. Having been involved in nitric oxide research for the past 18 years, he has made many seminal discoveries in that area.  After hearing Dr. Bryan speak on the podcast of a colleague, I decided to bring him into the Everyday Wellness Community. In today's discussion, we explore the role of nitric oxide as a signaling molecule crucial for communication within the body and examine how modern lifestyles affect nitric oxide production, looking at how to differentiate between the two nitric oxide pathways and understanding why our lifestyle choices significantly impact that. We discuss the importance of the oral microbiome and symbiosis, the harmful effects of fluoride, proton pump inhibitors, and mouthwash on our health, and cover the symptoms of low nitric oxide production, the impact of modern farming practices on the nutrient quality of our foods, and the differences between organic and conventional crops. Dr. Bryan highlights the importance of gender differences in nitric oxide production, particularly during perimenopause and menopause. We also explore various factors to avoid, the benefits of tongue scraping, the role of hydrochloric acid, and the importance of genetic testing for supporting nitric oxide production, and Dr. Bryan shares his view on how lifestyle choices and nitric oxide supplementation are as crucial as HRT in the aging process.  I am confident you will love this conversation with Dr. Nathan Bryan as much as I enjoyed recording it. IN THIS EPISODE YOU WILL LEARN: What nitric oxide is and why it is essential Dr. Bryan explains the process of nitric oxide synthesis in the body. The importance of oral bacteria in nitric oxide production and blood pressure regulation. Why nitrate is essential nitrate in the oral microbiome, and how it impacts the digestive system How fluoride can harm the oral microbiome and lead to nitric oxide deficiency. Why should the use of proton pump inhibitors be avoided? Why nitric oxide, derived from green leafy vegetables, is essential for cardiovascular health  How nitric oxide production decreases with age, particularly in women after menopause The benefits of tongue scraping and why you should not do it with antiseptic mouthwash Lifestyle factors that impact nitric oxide production The benefits of nitric oxide supplements Bio: Dr. Nathan Bryan Dr. Bryan is a successful CEO, scientist and international leader in molecular medicine and nitric oxide biochemistry. His patented discoveries and inventions that have improved patient care worldwide and are responsible for more than one billion dollars in global product sales. By way of background, Dr. Bryan was recruited in 2006 by Ferid Murad, M.D., Ph.D., 1998 Nobel Laureate in Medicine or Physiology to join faculty at the University of Texas Health Science Center, at Houston after a two-year post-doctoral Kirschstein fellowship at Boston University School of Medicine in the Whitaker Cardiovascular Institute. Since then, he has been dedicated to nitric oxide research and has made many seminal discoveries in the fi eld resulting in dozens of issued US and International patents. Connect with Cynthia Thurlow   Follow on Twitter Instagram LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Connect with Dr. Nathan Bryan  On his website On the N101 website On YouTube, LinkedIn, Instagram, and X The Heartbeat Happy Hour podcast  You will find 100's of peer-reviewed articles by Dr. Nathan S. Bryan on PubMed. Also, look out for his new book, coming out this fall, called The Secret of Nitric Oxide: Bringing Nitric Oxide to Life.

Subscribe to our channel: https://www.youtube.com/@optispan Related episodes: These 14 Medications are linked to lower death rates in humans: https://youtu.be/Ju1p_L-2Bq4 Is This The Best Time to Exercise?: https://youtu.be/59SFzLEy6Jg Matt recently attended the 52nd annual meeting of the American Aging Association (AGE) in Madison, Wisconsin and met with several people doing fascinating work in the longevity field. One of these was Berenice Benayoun, an Associate Professor (recently tenured!) of Gerontology, Biological Sciences, Biochemistry, and Molecular Medicine at the University of Southern California Leonard Davis School of Gerontology. Berenice delivered the keynote speech at the 2024 AGE meeting, where she received the 2024 Vincent Cristofalo Rising Star Award in Aging Research. Her research focuses on the influence of genomic regulation mechanisms, environmental stimuli, and factors such as biological sex on vertebrate aging and healthspan. Berenice was named a 2020 Pew Biomedical Scholar and a 2021 Nathan Shock new Investigator, and also received the 2019 Rosalind Franklin Young Investigator Award in Mammalian Genetics, an American Federation of Aging Research Junior Faculty Award, and a Global Consortium for Reproductive Longevity and Equality GCRLE Junior Scholar Award. In this episode, Matt and Berenice chat about the ovaries as a vehicle for understanding aging, the difference between estropause and menopause, and the controversies associated with hormone replacement therapy, and how Berenice made her way into the lab of her dreams. They also discuss the African turquoise killifish, a new vertebrate model organism for longevity research, and address a couple of questions about research we have recently featured on this podcast (how pregnancy affects aging, and sex-specific differences in the effects of estradiol on mouse aging). Producers: Tara Mei, Nicholas Arapis Video Editor: Jacob Keliikoa DISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices. More places to find us: Twitter: https://twitter.com/optispanpodcast Twitter: https://twitter.com/optispan Twitter: https://twitter.com/mkaeberlein Linkedin: https://www.linkedin.com/company/optispan https://www.optispan.life/ Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it. On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!

In this episode, we sit down with Elizabeth Harris, the author of What's Wrong with My Child and America Is Infected. She sits down with us today to discuss her work as a researcher and entrepreneur – specifically her distinct take on autoimmune conditions. With more than 20 years of experience in the field of wellness, Elizabeth is a science-minded business owner that is on a mission to educate medical professionals and other parents about her discoveries. Currently working on her Master's in Molecular Medicine, Elizabeth has dedicated her time to uncovering the strange disease that took her firstborn son's life. Identified as a mysterious bacteria, she believes this could be the primary cause of an array of other ailments in America… In this conversation, we cover: Elizabeth's history with health and wellness. How antibiotics fight invasive organisms. The importance of working with a health coach. The discoveries that Elizabeth has made over the course of her career. What is Elizabeth doing to get to the root of her family's medical issues? Tune in now to find out for yourself! To learn more about Elizabeth and her work, click here now! Take advantage of a 5% discount on Ekster accessories by using the code FINDINGGENIUS. Enhance your style and functionality with premium accessories. Visit bit.ly/3uiVX9R to explore latest collection. Episode also available on Apple Podcast: http://apple.co/30PvU9C

This episode of The Stem Cell Report will discuss the process of directing stem cells to acquire the proper identity, an essential step in the development of effective and durable cell replacement therapies. Specifically, we will talk about the process of directing cells into a ventral mesencephalic dopaminergic fate for treating Parkinson's disease. GuestsAgnete Kirkeby is an Associate Professor in the Department of Neuroscience at the University of Copenhagen, a Principal Investigator with the Novo Nordisk Foundation Center for Stem Cell Medicine renew, and a Principal Investigator at the Wallenberg Center for Molecular Medicine at Lund University. Professor Kirkeby led the preclinical development of a stem cell-based therapy for Parkinson's Disease which was approved for a first-in-human clinical trial in Sweden. Agnete also co-chairs the ISSCR 2024 Annual Meeting Program Committee, the group responsible for planning the upcoming meeting this July in Hamburg, Germany. Pedro Rifes received his PhD from the Universidade de Lisboa in Portugal and was a postdoctoral scholar in the Kirkeby Laboratory. He served as an Adjunct Assistant Professor at the University of Copenhagen and is currently a Project Manager at Bioneer A/S, a Danish specialty Contract Research Organization.  Connect with him on LinkedIn.HostMartin Pera, Editor-in-Chief, Stem Cell Reports and The Jackson Laboratory@martinperaJAXSupporting ContentPaper link: Forced LMX1A expression induces dorsal neural lolfates and disrupts patterning of human embryonic stem cells into ventral midbrain dopaminergic neurons, Stem Cell Reports About Stem Cell ReportsStem Cell Reports is the open access, peer-reviewed journal of the International Society for Stem Cell Research communicating basic discoveries in stem cell research, in addition to translational and clinical studies. Stem Cell Reports  focuses on original research with conceptual or practical advances that are of broad interest to stem cell biologists and clinicians. X: @StemCellReportsAbout ISSCRWith nearly 5,000 members from 75+ countries, the International Society for Stem Cell Research (@ISSCR) is the preeminent global, cross-disciplinary, science-based organization dedicated to stem cell research and its translation to the clinic. The ISSCR mission is to promote excellence in stem cell science and applications to human health.ISSCR StaffKeith Alm, Chief Executive OfficerYvonne Fisher, Managing Editor, Stem Cell ReportsKym Kilbourne, Director of Media and Strategic CommunicationsJack Mosher, Scientific AdvisorVoice WorkBen Snitkoff  

My friend Hannah Russell (married mother of three, PhD, lives in Cincinnati, active Latter-day Saint) joins us to share her story of being asexual out of a desire to help others not feel alone. Hannah starts realizing she is different and falsely concluding “I am not a divine child of Heavenly Parents” because I don't have any sexual interest. Hannah talks about how being asexual is a real thing and there isn't some backstory “confusing” Hannah to falsely make this conclusion. Hannah talks about learning more about herself at BYU and dating. Hannah is very brave—and without shame—in sharing her feelings about not wanting to be sexually intimate. Hannah talks about getting on with her life (after a broken off engagement) and getting her PhD in Pathobiology and Molecular Medicine. Hannah talks about meeting her husband John and opening up to him about being asexual and how they navigated that road together and decided to get married and start a family. Hannah talks about how their marriage—a beautiful love story—is based on communication and consent. I learned so much from Hannah story about how to better understand and support my asexual friends, and principles to create a stronger marriage and family. Thank you, Hannah, for your courage to share your story so others don't feel alone and all are welcome and needed as we create Zion. You are awesome! Links: Hannah's Facebook: https://www.facebook.com/hannah.russell.1428 Facebook Group to Better Support LGBTQ Latter-Day Saints: https://www.facebook.com/groups/1433556613672143

References The Journal of Biological Chemistry2018  293, 19001-19011 Cell Death & Diseasevolume 10, Article number: 315 Experimental & Molecular Medicine 2019. volume 51, Article number: 80. Trends in Immunology. 2017. REVIEW| VOL. 38,Issue 4, P287-297, April 01. Gastroenterology. 2023 Feb; 164(2): 256–271.e10 Squire/ Anderson. 1971. "The South Side of the Sky. on [ Yes -Fragile; lp] https://youtu.be/hBAauFYod80?si=bTGJiM-dCEsHjRnJ Mozart, WA. 1772. Symphony No. 25 in G minor, K. 183 https://youtu.be/rNeirjA65Dk?si=I8cdCyfO_FDlaBYc --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support

This week we get into AI in health care, generative and personalized medicine, the cure for cancer and why CoVID helped supercharge that and how AI is helping us live longer, healthier lives. Alex Zhavoronkov, the founder of AI-MedTech player Insilico joins us on TF to talk how health care is going to radically change over the next decade or two. An amazing deep dive. Don't miss it! Alex Zhavoronkov, PhD, is the founder and CEO of Insilico Medicine (insilico.com), a leading clinical-stage biotechnology company developing next-generation artificial intelligence and robotics platforms for drug discovery. He is also the founder and Chief Longevity Officer of Deep Longevity, Inc, a spin-off of Insilico Medicine developing a broad range of artificial intelligence-based biomarkers of aging and longevity servicing healthcare providers and life insurance industry. In 2020 Deep Longevity was acquired by Endurance Longevity (HK: 0575).Since 2014 he has invented critical technologies in the field of generative artificial intelligence and reinforcement learning (RL) for the generation of novel molecular structures with the desired properties and generation of synthetic biological and patient data. He also pioneered the applications of deep learning technologies for the prediction of human biological age using multiple data types, transfer learning from aging into disease, target identification, and signaling pathway modeling. Under his leadership, Insilico raised over $415 million in multiple rounds from expert investors, opened R&D centers in six countries or regions, partnered with multiple pharmaceutical, biotechnology, and academic institutions, nominated 11 preclinical candidates, and entered human clinical trials with AI-discovered novel target and AI-designed novel molecule.Prior to founding Insilico, he worked in senior roles at ATI Technologies (GPU company acquired by AMD in 2006), NeuroG Neuroinformatics, Biogerontology Research Foundation. Since 2012 he published over 160 peer-reviewed research papers, and 2 books including "The Ageless Generation: How Biomedical Advances Will Transform the Global Economy" (Macmillan, 2013). He serves on the advisory or editorial boards of Trends in Molecular Medicine, Aging Research Reviews, Aging, Frontiers in Genetics, and founded and co-chairs the Annual Aging Research, Drug Discovery and AI Forum (9th annual in 2022), the world's largest event on aging in the pharmaceutical industry. He did his two bachelor degrees at Queen's University in Canada, masters in biotechnology at Johns Hopkins, and PhD in biophysics at MSU. He is the adjunct professor of artificial intelligence at the Buck Institute for Research on Aging.

We are back for season 2 of It All Starts Here! Listen in as your longtime host Olivia Moir introduces you to our new hosts joining us this season, Kathryn Hunwick and Niamh Kenny. Kathryn is a a long-time educator, therapist and yogi, who's all about helping women and people assigned female at birth (AFAB) to understand and support themselves holistically: body, mind and spirit. She is currently completing her masters in women's health at UCL to further her work. Niamh has always been extremely passionate about science and in particular menstrual health. She completed her bachelors in Molecular Medicine in Dublin and is currently pursuing a masters in women's health here at UCL. This season, our mission remains the same: to bring awareness to critical topics in the fields of reproductive science and women's health, that are often pushed to the sidelines of conversation. We will also be shining a spotlight on the social aspects that shape these fields. From societal stigmas to cultural influences, we'll dive into the intersectionality of reproductive science and women's health uncovering the layers of complexity that often go unnoticed. On top of this, we will be branching out and bringing in guests from various institutions around the UK. Tune in to learn more, we are so excited to guide you through another season of learning and communicating about reproductive science and women's health! Follow us on instagram @itallstartsherepodcastucl Date of episode recording: 2024-02-28T00:00:00Z Duration: 00:05:52 Language of episode: English Presenter: Olivia Moir, Kathryn Hunwick, Niamh Kenny Guests: N/A Producer: Olivia Moir, UCL changemakers

The relentless search for effective cancer therapies has led to numerous breakthroughs in drug discovery and development. Advancements have emerged in recent years through the promising avenue of combination therapy, where two or more drugs are used synergistically to enhance their collective therapeutic effect. This strategy has shown significant potential in overcoming drug resistance, reducing side effects, and improving patient survival rates. In a new study, researchers Thomas M. Cardillo, Maria B. Zalath, Roberto Arrojo, Robert M. Sharkey, Serengulam V. Govindan, Chien-Hsing Chang, and David M. Goldenberg from Gilead Sciences and the Center for Molecular Medicine and Immunology demonstrated the significant antitumor effects of Sacituzumab govitecan, an anti-Trop-2-SN-38 antibody-drug conjugate, in combination with platinum-based chemotherapy. On February 22, 2024, their research paper was published in Oncotarget, entitled, “Sacituzumab govitecan plus platinum-based chemotherapy mediates significant antitumor effects in triple-negative breast, urinary bladder, and small-cell lung carcinomas.” Full blog - https://www.oncotarget.org/2024/03/14/antitumor-effects-of-sacituzumab-govitecan-plus-platinum-based-chemotherapy/ Paper DOI - https://doi.org/10.18632/oncotarget.28559 Correspondence to - Thomas M. Cardillo - Thomas.Cardillo1@Gilead.com Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28559 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, sacituzumab govitecan, Trop-2, SN-38, carboplatin, cisplatin About Oncotarget Oncotarget is an open-access, peer-reviewed journal that has published primarily oncology-focused research papers since 2010. These papers are available to readers (at no cost and free of subscription barriers) in a continuous publishing format at Oncotarget.com. Oncotarget is indexed and archived by PubMed/Medline, PubMed Central, Scopus, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science). Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957

Dr. Neelika Malavige is the Head of Dengue Global Programme and Scientific Affairs at the Drugs for Neglected Diseases Initiative and a Professor in the Department of Immunology and Molecular Medicine at the University of Sri Jayewardenepura. Her research focuses on dengue: its pathogenesis, vascular leak, immune correlates of protection, and biomarkers. She talks about the disease burden of dengue and her investigations into risk factors for severe disease. She also discusses her research on COVID-19 vaccines and the role of the microbiome in colon cancer, as well as how she's working to grow research capabilities in Sri Lanka.

We sit down with the extraordinary Linh Aven, a chef who's seamlessly blending the realms of science and culinary arts. Our latest episode is more than just a conversation; it's a journey through Linh's transition from the world of molecular medicine to the forefront of the culinary industry. We reminisce about times spent restaurant consulting and how Linh's bold leap into sustainable farming is reshaping our relationship with food.As we wander through the enchanting world of foraging, I share my familial ties to the ancient practice, while Linh enlightens us on the transformative potential of natural ingredients like pine syrup and shagbark hickory. Our discussion ventures into the wild, offering a primer on the art of foraging with respect and wisdom, and unveiling the hidden flavors that nature bestows upon those who seek them. Linh and I underline the importance of safe foraging and the profound respect for the land that it entails, as we reveal how these foraged treasures are revolutionizing culinary innovation.We tackle the pressing issues of sustainability and the future of farming. Listen as we delve into the heart of sustainable practices, from the significance of soil health to the art of seed saving. We celebrate the resilience of local farms, especially in the wake of global challenges, and discuss the necessity of nurturing a new generation of passionate farmers. Through the story of Linh's farm and our shared insights, we aim to inspire listeners to reflect on the food we eat and the earth it comes from, emphasizing that the roots of our future lie in the passion and perseverance of those who cultivate it.Thank you Chef Linh!!https://www.dandelionforestfarm.com/Thank you to our listeners!! Contact & More Info:https:/www.chefmassey.com https://www.instagram.com/chef_massey/Other Sponsors & Discount Programs:https://www.chefmassey.com/services-9Studio Recording & Editing Support:Intro/Outro Creatorhttps://www.jacksonwhalan.com/Podcast Disclaimer:We are not responsible for any losses, damages, or liabilities that may arise from the use of this podcast. This podcast is not intended to replace professional medical advice. The views expressed in this podcast may not be those of the host, guest or the management. All right reserved under Chef Sense Podcast and Chef Massey, LLC.

We're adding "animal intelligence" to rsr.org/squeeze. The claim that apes should have the highest intelligence in the animal kingdom because we humans supposedly evolved from them turns out to be yet another fail. Did you know, for example, that certains species of birds demonstrate that they know what other birds are thinking? On today's Real Science Radio program Bob Enyart and Fred Williams discuss really fun and hugely significant examples of animal intelligence! Wait till you can hear what the lowly ant does! RSR thanks Answers in Genesis for publishing Dr. Joe Francis' article Smarter Than You Think which we've used as a framework for today's broadcast.  From kgov.com/definitions: These are RSR-styled... - Animal: Excepting humans, a multicellular biological organism with specialized sense organs and voluntary movement. - Mammal: A warm-blooded vertebrate animal with hair or fur, females that secrete milk, and, except for the platypus and spiny anteater, the birth of live young. - Animal Kingdom: The animals of the world collectively, excluding insects and fish (which are more likened to biological robots than to volitional organisms) - Human being: A person, made in God's likeness, with body, soul and spirit (whereas animals have body and soul) - Plant: A biological organism that synthesizes nutrients in its leaves by photosynthesis (possessing a body but neither a soul or spirit). * One minute video of a magpie perceiving what many apes don't:  * Otherwise, this is a great video on mole rats vocalizing: If you ignore the absurd claim made by Dr. Gary Lewin of Berlin's Max Delbrück Center for Molecular Medicine about mole rats and human social behavior, this video announces extraordinary research and an exciting discovery! (If you have a choice, you might want to avoid the Max Delbrück Center for your own medical treatment. Researchers who remain so oblivious to the ubiquitous evidence against Darwinian rsr.org/evolution may also miss the insights needed to save your life.)  

View the Show Notes For This EpisodeGet Free Weekly Health Tips from Dr. HymanSign Up for Dr. Hyman's Weekly Longevity JournalGet Ad-free Episodes & Dr. Hyman+ Audio ExclusivesDr. Eric Topol is the Founder and Director of the Scripps Research Translational Institute, Professor of Molecular Medicine, and Executive Vice-President of Scripps Research. He has published over 1,200 peer-reviewed articles with more than 330,000 citations, was elected to the National Academy of Medicine, and is one of the top 10 most cited researchers in medicine. His principal scientific focus has been on individualized medicine using genomic, digital, and AI tools.This episode is brought to you by Rupa Health, Pendulum, Thrive Market, and Fatty15.Streamline your lab orders with Rupa Health. Access more than 3,000 specialty lab tests and register for a FREE live demo at RupaHealth.com.Pendulum is offering listeners 20% off their first month's subscription of Akkermansia for gut health. Visit PendulumLife.com and use code HYMAN.Head over to thrivemarket.com/Hyman today to receive 30% off your first order and a free gift up to $60.Fatty15 contains pure, award-winning C15:0 in a bioavailable form. Get an exclusive 10% off a 90-day starter kit subscription. Just visit Fatty15.com and use code DRHYMAN10 to get started.In this episode we discuss (audio version / Apple Subscriber version):The first phase of AI's application in medicine (7:19 / 5:40)How medicine will incorporate AI over the next few years (9:59 / 8:19)Retinal imaging (16:45 / 15:05)Expert-informed AI (20:02 / 18:23)The impending and biggest shake-up in the history of medicine (22:18 / 20:38)How AI can improve issues of medical error (26:08 / 24:29)Using AI to personalize medicine and prevent disease (33:01 / 29:11)The obesity crisis and toxic food environment (41:04 / 37:14)How AI can help restore the patient-doctor relationship (46:53 / 43:03)Using AI as a guide for medical self care (50:34 / 46:44)Reimagining research in the era of AI-enabled medicine (56:58 / 53:07)Dr. Topol's Substack, Ground Truths.Deep Medicine: How Artificial Intelligence Can Make Healthcare Human Again Hosted on Acast. See acast.com/privacy for more information.

In this episode of Life Science Success, my guest is Dr. Thomas Rademacher. Professor Rademacher, MD, PhD, co-founded Emergex and has served as CEO since the Company's formation. He is an Emeritus Professor of Molecular Medicine at University College London (UCL) and a serial entrepreneur.   Dr. Thomas Rademacher, MD, PhD, is the co-founder and CEO of Emergex, with a background as an Emeritus Professor of Molecular Medicine at the University College of London and a serial entrepreneur. His career has oscillated between academic and entrepreneurial roles, adhering to the philosophy of not staying in the same job for more than ten years. Rademacher's academic foundation in hardcore biochemistry was established during his PhD at the University of Wisconsin Madison. This rigorous training in biochemistry has been a cornerstone throughout his career, enabling him to navigate and innovate in the complex field of molecular medicine. His work has significantly contributed to the field of monoclonal antibodies, starting with foundational research at Oxford and involving the use of Chinese hamster ovary (CHO) cells. This work was pivotal for the development of recombinant proteins and monoclonal antibodies, leading to advancements in medicine. Rademacher has been involved in groundbreaking research and entrepreneurial ventures, including the Glycobiology Institute, which attracted interest from major corporations like Monsanto. His work has led to significant scientific advancements and the formation of companies that have had substantial impacts on the medical and biotechnological landscapes. He is currently focused on challenges in vaccinology and immunology, particularly in developing vaccines that activate the cellular immune response to fight viral infections effectively. Rademacher's innovative approach involves utilizing quantum-confined gold clusters and micro-needle technology to enhance vaccine delivery and efficacy.

Nicolas Verhoeven is a PhD Candidate in Molecular Medicine who works in a mitochondria and autophagy laboratory; he also holds a Masters in Exercise Physiology. Verhoeven runs Physionic, a brand that bridges the gap between scientific studies and the public's understanding by opening studies, showing and explaining the data, and explaining the physiology that underlies that data. One of his missions is to improve the public's understanding of the scientific literature without sacrificing the details (or the fun!).In this episode we discuss:How to improve your mitochondrial health.The best skin supplements.Common misconceptions about Autophagy and how to trigger it.Which forms of training increase muscular power?This episode is brought to you by Thesis, Timeline Nutrition, Inside Tracker, 1stPhormPhysionic YouTubeFollow NicolasPhysionicMentioned in this episode:Get 10% off your first boxhttps://takethesis.com/drlyon/ Get your free LMNT Sample Pack with any purchasehttps://drinklmnt.com/drlyonInside Tracker 20% Off the Entire Storehttps://info.insidetracker.com/drlyon10% off your first order of Mitopurehttps://timelinenutrition.com/DRLYONVisit 1st Phorm Website for Free Shipping on orders $75+http://www.1stphorm.com/drlyon