Nootralize Podcast

https://nootralize.com/nootropics/coffee *** This is the last episode in a while of the Nootralize podcast. We will upload more episodes if we see that more people listen to the ones that we've already released.

https://nootralize.com/nootropics/cocoa

https://nootralize.com/nootropics/citrulline

https://nootralize.com/nootropics/bacopamonnieri

https://nootralize.com/nootropics/bpc157

https://nootralize.com/nootropics/citicoline

https://nootralize.com/nootropics/ashwagandha

https://nootralize.com/nootropics/arginine

https://nootralize.com/nootropics/chlorogenicacid

https://nootralize.com/nootropics/aniracetam

https://nootralize.com/nootropics/panaxquinquefolius

https://nootralize.com/nootropics/caffeine

https://nootralize.com/nootropics/adrafinil

https://nootralize.com/nootropics/modafinil

https://nootralize.com/nootropics/bromantane

https://nootralize.com/noootropics/5htp

https://nootralize.com/nootropics/blueberry

https://nootralize.com/nootropics/78dihydroxyflavone

https://nootralize.com/nootropics/alphagpc Find the most science-backed nootropics for the effects that you want: https://nootralize.com/search

nootralize.com/nootropics/alphalipoicacid

https://nootralize.com/nootropics/agmatine

In this episode, David talks with Grega Gostincar from YourInception. They chat about how to get going with nootropics self-experimentation, how to think about placebo effects, and how he and his team at YourInception review nootropic products. YourInception Website: https://www.yourinception.com/ YourInception YouTube: https://www.youtube.com/channel/UCyA_Is3pTm5x1s76Lr_h5oQ Nootropics talked about in this podcast: * Nicotine: https://nootralize.com/nootropics/nicotine * Rhodiola: https://nootralize.com/nootropics/rhodiola * Caffeine: https://nootralize.com/nootropics/caffeine * L-Theanine: https://nootralize.com/nootropics/theanine * Bacopa Monnieri: https://nootralize.com/nootropics/bacopamonnieri * Lion's Mane: https://nootralize.com/nootropics/lionsmane Nootralize links: * https://nootralize.com - Web App * https://blog.nootralize.com - Blog

How to use Caffeine for cognitive performance enhancement is the topic of today's Nootralize podcast episode. Expect practical tips on: * When to use Caffeine * What source of Caffeine to use * What dose of Caffeine to use * How often to use Caffeine ... and much more Episode Resources: * https://nootralize.com/nootropics/caffeine - Caffeine Nootropic Page in the Nootralize web app * https://nootralize.com/nootropics/greentea - Green Tea Nootropic Page in the Nootralize web app * https://nootralize.com/nootropics/theanine - Theanine Nootropic Page in the Nootralize web app * https://podcasts.apple.com/us/podcast/science-mechanisms-effectiveness-nootropics-prof-andrew/id1485140999?i=1000485502804 - Andrew Scholey on the Nootralize Podcast talking about Green Tea, Caffeine, and Brain Blood Flow Nootralize links: * https://nootralize.com - Web App * https://blog.nootralize.com - Blog * https://blog.nootralize.com/nootralize-podcast - Podcast

In this episode of the Nootralize podcast, David and Max chat about what has helped them get the most out of intermittent fasting for the purposes of boosting energy levels and productivity. You will get practical tips and tricks regarding how to self-experiment with intermittent fasting to feel and perform better. These tips include: * When to fast * How long to fast * What to eat before a fast * How much to eat after a fast ... and much more Nootralize links: * nootralize.com - Web App * blog.nootralize.com - Blog * www.youtube.com/channel/UCAmoqLdhY3YeZZ7e9TIxvKQ - YouTube

Out of the 527 studies, 38 included measures of nervousness. A total of 2420 participants had their nervousness tested, and 12 nootropics were assessed for safety and efficacy for improving levels of nervousness. Based on this body of evidence, these are the 5 most science-backed nootropics for reducing nervousness in healthy humans. Episode resources: * https://blog.nootralize.com/top-5-best-nootropics-for-nervousness-in-healthy-people-according-to-science/- Blog post containing the full list of the top 5 most science-backed nootropics for reducing nervousness * https://nootralize.com - Web App Nootropics we talked about during this episode: * https://nootralize.com/nootropics/lemonbalm - Lemon Balm Nootropic Page in the Nootralize web app * https://nootralize.com/nootropics/sage - Sage Nootropic Page in the Nootralize web app

In this episode, David talks with Mark Tommerdahl from Cortical Metrics. They chat about the science behind reaction time measures, the different effects of low and high doses of Caffeine or Alcohol, and the Brain Gauge tool that Mark has been involved in the development of. Buy the Brain Gauge tool (self-experimenter version for $499 (-$99.8=$399.2 via our discount)): * https://corticalmetrics.com/brain-gauge/ - Enter code "Nootralize" for a 20% discount Nootropics talked about in this podcast: * Alcohol: https://nootralize.com/nootropics/alcohol * Walnut: https://nootralize.com/nootropics/walnut * Caffeine: https://nootralize.com/nootropics/caffeine * Ginkgo Biloba: https://nootralize.com/nootropics/ginkgobiloba Nootralize links: * https://nootralize.com - Web App * https://blog.nootralize.com - Blog

Episodic memory, reaction time, and executive functions were enhanced after the equivalent of one cup of wild blueberries in this brand new placebo-controlled study published on the 3rd of August 2020, just a week ago when this podcast episode is released. If you enjoy the Nootralize podcast, we would really appreciate a 5-star review on iTunes. (https://podcasts.apple.com/podcast/nootralize-podcast/id1485140999) Episode resources: * Blueberry page in Nootralize web app: https://nootralize.com/nootropics/blueberry * Blog version of pod: https://blog.nootralize.com/blueberries-improve-cognitive-performance-in-middle-aged-healthy-adults/ Nootralize links: * https://nootralize.com - Web App * https://blog.nootralize.com - Blog

Out of the 527 studies we've reviewed, 5 included measures of sleep. A total of 422 healthy human participants had their sleep tested, and 4 nootropics were assessed for safety and efficacy for improving levels of stress. Based on this body of evidence, these are the 4 most science-backed nootropics for improving sleep in healthy humans. Episode resources: * https://blog.nootralize.com/top-5-best-nootropics-for-sleep-in-healthy-people-according-to-science - Blog post containing the full list of the top 4 most science-backed nootropics for improving sleep * https://nootralize.com - Web App Nootropics we talked about during this episode: * https://nootralize.com/nootropics/lionsmane - Lion's Mane Nootropic Page in the Nootralize web app * https://nootralize.com/nootropics/turmeric - Turmeric Nootropic Page in the Nootralize web app

Stacking nootropics, using pre-made stacks, and using racetams - are these things you should do? Some people should. Find out if you are a person that nootropic stacks are a good fit for with David and Max on this episode of the Nootralize podcast. If you enjoy the Nootralize podcast, we would really appreciate a 5-star review on iTunes. (podcasts.apple.com/podcast/nootral…st/id1485140999) Episode resources: * Blog version of pod: https://blog.nootralize.com/should-you-combine-nootropics-into-a-stack/ Nootralize links: * https://nootralize.com - Web App * https://blog.nootralize.com - Blog

In this episode, David talks about how to avoid unintentionally breaking the law when using, buying, or traveling with nootropics. If you enjoy the Nootralize podcast, we would really appreciate a 5-star review on iTunes. (https://podcasts.apple.com/podcast/nootralize-podcast/id1485140999) Episode resources: * Blog: https://blog.nootralize.com/the-legality-of-nootropics%e2%80%8a-%e2%80%8abuying-online-traveling-with-and-using-cognitive-enhancers-2/ Nootralize links: * https://nootralize.com - Web App * https://blog.nootralize.com - Blog

Out of the 527 studies we've reviewed, 34 included measures of stress. A total of 2038 healthy human participants had their stress levels tested, and 11 nootropics were assessed for safety and efficacy for improving levels of stress. Based on this body of evidence, these are the 5 most science-backed nootropics for stress reduction in healthy humans. Episode resources: * https://blog.nootralize.com/top-5-best-nootropics-for-stress-in-healthy-people-according-to-science/ - Blog post containing the full list of the top 5 most science-backed nootropics for stress reduction * https://nootralize.com - Web App * https://nootralize.com/nootropics/panaxginseng - Panax Ginseng Nootropic Page in the Nootralize web app * https://nootralize.com/nootropics/ashwagandha - Ashwagandha Nootropic Page in the Nootralize web app * https://blog.nootralize.com/supercharge-your-brain-principles-of-safe-nootropic-use/ - Article on using nootropics in a safe and sustainable manner * https://blog.nootralize.com/how-nootralize-researches-nootropics/ - How we at Nootralize research nootropics Nootralize links: * nootralize.com - Web App * blog.nootralize.com - Blog * www.youtube.com/channel/UCAmoqLdhY3YeZZ7e9TIxvKQ - YouTube

A use case for Caffeine with long-term positive effects on your life is using it when taking a test in school or to get your drivers license. The increased alertness you may experience can lead to better cognitive performance, and therewith better test results. The better test results can enable you to study at the university you want, or get your dream job. To learn more about using cognitive enhancers for long term career success, listen to this episode of the Nootralize podcast. Episode resources: * Blog: https://blog.nootralize.com/enhancing-cognitive-performance-for-long-term-career-success/ Nootralize links: * https://nootralize.com - Web App * https://blog.nootralize.com - Blog * https://soundcloud.com/@nootralize - SoundCloud (Podcast)

In this episode, David talks with professor Andrew Scholey about his research during the past decades on many different substances and their effects on cognitive performance. Andrew is a living legend in the field of cognitive enhancement psychopharmacology, so you'll learn a lot from listening to this podcast. Nootropics talked about in this podcast: * Alcohol: https://nootralize.com/nootropics/alcohol * Glucose: https://nootralize.com/nootropics/glucose * Caffeine: https://nootralize.com/nootropics/caffeine * Chlorogenic Acids: https://nootralize.com/nootropics/chlorogenicacids * Panax (Asian) Ginseng: https://nootralize.com/nootropics/panaxginseng * Panax Quinquefolius(American Ginseng): https://nootralize.com/nootropics/panaxquinquefolius * Lemon Balm: https://nootralize.com/nootropics/lemonbalm * Curcumin: https://nootralize.com/nootropics/turmeric Nootralize links: * https://nootralize.com - Web App * https://blog.nootralize.com - Blog * https://soundcloud.com/@nootralize - SoundCloud

Out of the 527 studies we've reviewed, 29 included measures of mindfulness. A total of 1693 healthy human participants had their mindfulness tested, and 11 nootropics were assessed for safety and efficacy for improving levels of mindfulness. Based on this body of evidence, these are the 5 most science-backed nootropics for increasing mindfulness in healthy humans. Episode resources: * Blog version: https://blog.nootralize.com/top-5-best-nootropics-for-mindfulness-in-healthy-people-according-to-science * https://blog.nootralize.com/how-nootralize-researches-nootropics/ - Our research methodology that underlies the ranking of nootropics * https://nootralize.com - Web App Nootralize links: * nootralize.com - Web App * blog.nootralize.com - Blog * www.youtube.com/channel/UCAmoqLdhY3YeZZ7e9TIxvKQ - YouTube

Learn how to harness acute nootropic effects for optimal long-term cognitive enhancement Episode resources: * Blog: https://blog.nootralize.com/a-short-term-mindset-is-actually-good-when-using-nootropics Nootralize links: * https://nootralize.com - Web App * https://blog.nootralize.com - Blog * https://soundcloud.com/@nootralize - SoundCloud (Podcast)

Out of the 527 studies we've reviewed on the effects of nootropics, 36 included measures of mood. A total of 2665 participants had their mood tested, and 13 nootropics were assessed for safety and efficacy for improving mood. Based on this body of evidence, these are the 5 most science-backed nootropics for boosting mood in healthy humans. Episode resources: * Blog version: https://blog.nootralize.com/top-5-best-nootropics-for-mood-in-healthy-people-according-to-science/ * https://blog.nootralize.com/how-nootralize-researches-nootropics/ - Our research methodology that underlies this top 5 ranking * https://nootralize.com - Web App Nootralize links: * https://nootralize.com - Web App * https://blog.nootralize.com - Blog * www.youtube.com/channel/UCAmoqLdhY3YeZZ7e9TIxvKQ - YouTube

Nootropic mistakes can lead to an absence of benefits and the presence of unwanted side effects. Avoid these common nootropic use mistakes to get the most out of your nootropic use. Episode resources: * Blog version: https://blog.nootralize.com/10-nootropic-use-mistakes-to-avoid/ Nootralize links: * https://nootralize.com - Web App * https://blog.nootralize.com - Blog * https://www.youtube.com/channel/UCAmoqLdhY3YeZZ7e9TIxvKQ - YouTube

We at Nootralize value ethical research highly. This is why we intend to apply the ethical principles of psychological testing laid out by the American Psychological Association in the “Standards for Educational and Psychological Testing” and “Ethical Principles of Psychologists and Code of Conduct”, and the World Medical Association guidelines outlining principles for ethical medical research involving human participants. While the Nootralize app largely follows these standards, the nature of the application makes for variability in the relevance of some of the ethical guidelines. If you want to understand how we approach ethical nootropic research on healthy human subjects, this podcast episode is for you. Episode resources: * Video: https://youtu.be/MeZljNxZW3E * Blog: https://blog.nootralize.com/the-ethics-of-the-nootralize-web-app%e2%80%8a-%e2%80%8apsychological-testing-and-human-medical-research/ Nootralize links: * https://nootralize.com - Web App * https://blog.nootralize.com - Blog * https://www.youtube.com/channel/UCAmoqLdhY3YeZZ7e9TIxvKQ - YouTube

Establishing solid side effect prevention habits is crucial for successful long term cognitive enhancement. These 6 habits have been selected because they're likely to give you the most bang for the buck as regards invested time and effort. Blog version: https://blog.nootralize.com/6-habits-for-nootropic-side-effect-prevention/ Nootralize links: * https://nootralize.com - Web App * https://nootralize.com - Website * https://soundcloud.com/@nootralize - SoundCloud * https://medium.com/@nootralize - Medium * https://twitter.com/nootralize - Twitter * https://linkedin.com/company/nootralize - LinkedIn

How effective is CoQ10 for enhancing energy levels, motivation, and cognitive performance? David and Max discuss a study published in the Journal "Nutrients" on the cognitive and fatigue-relieving effects of Ubiquinol to find out. Nootralize links: * https://nootralize.com - Web App * https://nootralize.com - Website * https://soundcloud.com/@nootralize - SoundCloud * https://medium.com/@nootralize - Medium * https://twitter.com/nootralize - Twitter * https://linkedin.com/company/nootralize - LinkedIn

In this episode, David and Max discuss how to brand Nootralize to maximize the amount of users that use the app so that they can help them feel and perform better. They ponder how science can be used to inspire self-improvement. Nootralize links: * https://beta.nootralize.com - Web App * https://nootralize.com - Website * https://soundcloud.com/@nootralize - SoundCloud * https://medium.com/@nootralize - Medium * https://twitter.com/nootralize - Twitter * https://linkedin.com/company/nootralize - LinkedIn

In this episode of the Nootralize Podcast, David and Max discuss whether they should conduct a systematic review of the 50+ studies they've gathered on the effects of nootropics for cognitive enhancement or if they should settle for a less formal approach to save time. Nootralize links: * https://beta.nootralize.com - Web App * https://nootralize.com - Website * https://soundcloud.com/@nootralize - SoundCloud * https://medium.com/@nootralize - Medium * https://twitter.com/nootralize - Twitter * https://linkedin.com/company/nootralize - LinkedIn

Get to know if blueberries impact cognitive performance and how the Nootralize podcast will continue on a new path. Nootralize links: * https://beta.nootralize.com - Web App * https://nootralize.com - Website * https://soundcloud.com/@nootralize - SoundCloud * https://medium.com/@nootralize - Medium * https://twitter.com/nootralize - Twitter * https://linkedin.com/company/nootralize - LinkedIn

In this podcast, David and Dr. Dan Engle talk about publication bias and how spirituality, practising gratitude and having great relationships may be among the strongest indicators for well being. Video version: https://youtu.be/lBVBeceJqbI Dr. Dan Engle * https://drdanengle.com/ * https://fullspectrummedicine.com/ * https://www.amazon.com/Concussion-Repair-Manual-Practical-Recovering/dp/1946697346 Nootralize links: * beta.nootralize.com - Web App * nootralize.com - Website * soundcloud.com/@nootralize - SoundCloud * medium.com/@nootralize - Medium * twitter.com/nootralize - Twitter * linkedin.com/company/nootralize - LinkedIn

In this episode, David talks to Clay Drinko about improvisation theatre and how playing along with fictive interactions can push your creativity by silencing your inner critic. They dig into how creating an atmosphere where it's impossible to mess up can reduce anxiety and change mindsets towards taking risks. Video version: https://youtu.be/bm0KvGRxB9k Clay Drinko: * https://www.playyourwaysane.com/ * https://www.psychologytoday.com/us/experts/clay-drinko-phd Nootralize links: * https://beta.nootralize.com - Web App * https://nootralize.com - Website * soundcloud.com/@nootralize - SoundCloud * medium.com/@nootralize - Medium * twitter.com/nootralize - Twitter * linkedin.com/company/nootralize - LinkedIn

In this episode, David chats with neurologist and author Richard Cytowic who brought synesthesia to mainstream science in the 80s. They talk about what synesthesia is, whether you can train it, and how it influences cognitive performance. Video version: https://youtu.be/_swWjh3CB7A Shownotes: 00:50 - 02:40 What is synesthesia? * Joined/couple sensation * Seeing sounds, hearing shapes, or tasting colours * Is it hereditary or trainable? * Born on a blue day - https://www.amazon.com/Born-Blue-Day-Extraordinary-Autistic/dp/1416549013 * 4% of people have it 02:40 - 05:43 How does synesthesia influence memorization? * It improves it * Spatial and episodic memory enhancement through extra connections 05:44 - 11:05 What distinguishes a synesthetic brain from a non-synesthetic brain? The developmental psychology of synesthesia. * More cross-connections * Are we all synesthetes? Are children synesthetes? ** Interplay between nature and nurture 11:16 - 15:19 Synesthesia enhances creativity * Seeing the similar in the dissimilar * Convergent creativity is similar to synesthesia, and synesthesia may enhance convergent creativity 15:21 - 16:13 Synesthesia and psychosis 16:17 - 18:31 The negatives of synesthesia * Social embarassment * Unpleasant connections * Bidirectional synesthesia can be confusing 18:34 - 21:33 What questions regarding the neurology of synesthesia are currently being researched? * How synesthesia is developed * How does a deep understanding of how we perceive things differently influence our mindfulness of other people’s experiences? 21:35 - 24:18 Mindfulness meditation and synesthetic experiences * Boosts the odds * Mindfulness va psychedelics for synesthesia 24:19 - 30:34 Cognitive biases against novel ideas - Hinders scientific thinking * Ideas not included in orthodoxical frameworks are sometimes denied/dismissed ** Synesthesia ** Nootropics * Some novel ideas may turn out to not be true, but before we know, let’s not have strong opinions regarding them Richard Cytowic links: * https://cytowic.net - Website * https://www.psychologytoday.com/us/blog/the-fallible-mind - Richard's Psychology Today Column * https://cytowic.net/writing/books/synesthesia/ - Synesthesia Book * https://twitter.com/cytowic - Richard's Twitter Nootralize links: * https://beta.nootralize.com - Web App * https://nootralize.com - Website * https://soundcloud.com/@nootralize - SoundCloud * https://medium.com/@nootralize - Medium * https://twitter.com/nootralize - Twitter * https://linkedin.com/company/nootralize - LinkedIn

In this episode, David chats with entrepreneur, podcast host, and personal trainer Sal Di Stefano. They chat about how to get good results from exercise with little invested effort. They also talk about how to exercise, eat, and meditate for cognitive enhancement purposes. YouTube Version of Podcast: https://youtu.be/-mn_dwpiQRI Shownotes: 01:00 - 14:16 How does one get the most results from their exercise in the least amount of time? * Lift weights * Practice the right technique ** Be mindful ** Watch YouTube videos or hire a personal trainer * Compound movements * At least 2-3 days/week - Start with 5 exercises 14:17 - 25:00 How should you exercise, sleep, and eat to enhance your cognitive performance? * Be healthy * Establish sleep habits ** Remove bright lights (e.g. phone lights) * Whole foods - Unprocessed * Keto * Resistance training ** Forces you to be present ** Insulin sensitivity ** Proprioceptive training 25:01 - 33:04 How to recover faster from long-distance running * Don’t push yourself every time * Sauna * Cold shower/bath 33:05 - 35:56 How should consumers approach underresearched supplements? * If a compound has a long history of use with few documented side effects and consistent anecdotal benefits; that is a good sign * Listen to your body 36:06 - 40:58 How does Sal effectively communicate the science behind different interventions via his YouTube channel and podcast? * Experience lead to competence * Learn how to tell stories/anecdotes * Meet the listener/viewer/client where they are * @mindpumpsal on IG - https://www.instagram.com/mindpumpsal/ * Search for ”MindPump” on any podcast platform * Free exercise and nutrition blog content - https://mindpumpfree.com Nootralize links: * https://beta.nootralize.com - Nootralize App Beta * https://nootralize.com - Website/Blog * https://soundcloud.com/@nootralize - SoundCloud * https://medium.com/@nootralize - Medium * https://twitter.com/nootralize - Twitter * https://linkedin.com/company/nootralize - LinkedIn

In this episode of The Nootralize Podcast, David chats with Clinical Psychologist, author, and online course creator Seth Gillihan about Cognitive Behavioral Therapy. They talk about the research behind CBT and have a live CBT session in which they discuss a real problem from David's life. Video version: https://youtu.be/hei5gY2M7XQ Shownotes: 1:20 - 5:54 Is Cognitive Behavioral Therapy effective? * What does the research say? * How does it compare to other therapy-forms? * What is it effective for? ** Obsessive Compulsive Disorder ** Anxiety ** Depression ** Panic ** Stress 5:56 - 10:15 In-depth description of CBT * The cognitive component ** You are not your thoughts * The behavioral component ** Exposure - Face your fears * How is mindfulness incorporated into CBT? ** Bring awareness to your current patterns of thought and action 10:20 - 38:25 Live CBT-session with an IRL-problem from David’s life Seth J. Gillihan, PhD, is a licensed psychologist and host of the weekly Think Act Be podcast. He is author of The CBT Deck, Retrain Your Brain, and Cognitive Behavioral Therapy Made Simple, and co-author with Dr. Aria Campbell-Danesh of A Mindful Year: 365 Ways to Find Connection and the Sacred in Everyday Life. Dr. Gillihan provides resources for managing stress, anxiety, and other conditions on the Think Act Be website, including his free e-guide, "10 Ways to Manage Stress and Anxiety Every Day." He offers a course in mindfulness-centered CBT for anxiety, stress, and worry through the Think Act Be Online School. * https://podcasts.apple.com/us/podcast/think-act-be-aligning-thought-action-and-presence/id1419082632 - Think Act Be podcast * https://www.amazon.com/CBT-Deck-Practices-Improve-Thoughts/dp/1683732464/ - The CBT Deck, Retrain Your Brain, and Cognitive Behavioral Therapy Made Simple * https://www.amazon.com/Mindful-Year-Connection-Sacred-Everyday/dp/1982501839 - A Mindful Year: 365 Ways to Find Connection and the Sacred in Everyday Life * http://sethgillihan.com/ - Think Act Be website * http://bit.ly/CBT4Stress 10 - Ways to Manage Stress and Anxiety Every Day * http://bit.ly/CBTanx - Think Act Be Online School Nootralize links: * https://beta.nootralize.com - Web App * https://nootralize.com - Website * https://soundcloud.com/@nootralize - SoundCloud * https://medium.com/@nootralize - Medium * https://twitter.com/nootralize - Twitter * https://linkedin.com/company/nootralize - LinkedIn

Are neurotechnologies effective or dangerous? What is an ethical way of moving forward with these powerful brain-machine tools? David chats with neuroscientist Marcello Ienca about the "neurorights" that he and his colleagues suggested should be added to the already existing human rights. Shownotes: 00:54-09:04 Nootropic Study of the Week #3 - Bacopa Monnieri for Executive Functioning, Learning, and Attention * Excerpt of Nootralize's interview with Steven Roodenrys: https://youtu.be/cO15O72o_CM * Nootralize App Page for Bacopa Monnieri: https://beta.nootralize.com/nootropics/bacopamonnieri 09:17-11:56 Why do we need new human rights to deal with the implications of new neurotechnologies? 11:56-44:11 Which new human rights have Marcello and his fellow researchers suggested? 44:11 - 51:15 Can currently commercially available neurodevices such as tDCS or tACS be hacked? 51:15 - 59:10 Are the currently (2020) available neural devices effective? * https://www.nature.com/articles/s41593-019-0371-x - Working memory revived in older adults by synchronizing rhythmic brain circuits * What are the barriers to developing more effective neurotechnologies? Learn more about Marcello: https://bioethics.ethz.ch/the-group/people/person-detail.marcello-ienca.html Nootralize links: * https://beta.nootralize.com - Nootralize App Beta * https://nootralize.com - Website/Blog * https://soundcloud.com/@nootralize - SoundCloud * https://medium.com/@nootralize - Medium * https://twitter.com/nootralize - Twitter * https://linkedin.com/company/nootralize - LinkedIn

In this episode, David interviews Jerome Sarris, a Kava researcher. Kava has anxiolytic and stress-reducing effects and may also boost concentration and mood. Shownotes: 0:35-4:30 Nootropic Study of the Week #2 - Ashwagandha for Anxiety * https://youtu.be/GAO3Dbrz9zw * https://beta.nootralize.com/nootropics/ashwagandha 4:45-06:00 What is Kava? 06:00-09:42 How to use Kava (form, time of day, contexts) * Studying * Sleep * Events that spur anxiety (public speaking) 10:00-18:50 Is Kava effective for stress and anxiety? * What does the science say? ** May boost focus ** Reduces anxiety ** May boost mood ** Reduces stress levels * Who does it work for? * Kava is better than alcohol: reduces anxiety but doesn’t impair cognitive functions (and isn’t addictive) 18:50-21:32 Is Kava addictive? * Kava is not addictive 21:32-26:24 Personalizing Kava treatment based on individual users’ pharmacogenomics * GABA transporters and the SNPs that code for them may influence response to Kava * Is DYI-pharmacogenomics (online genetic testing and analysis) useful as of 2020? 26:25-28:10 Neuropharmacological effects of Kava * Calcium and sodium channels * GABA pathway ** CNS suppression/inhibition * Dopaminergic * Noradrenergic * Different dosages yield different neurological effects 28:10-30:32 Do you build tolerance to Kava? * No 30:34-32:35 What is the ”declaration of conflict of interest” section at the end of scientific studies? Jerome Sarris NICM profile: https://nicm.edu.au/about_us/people/researchers/jerome_sarris Nootralize links: * https://beta.nootralize.com - Web App * https://nootralize.com - Website * https://soundcloud.com/@nootralize - SoundCloud * https://medium.com/@nootralize - Medium * https://twitter.com/nootralize - Twitter * https://linkedin.com/company/nootralize - LinkedIn

Welcome to the new Nootralize series "Nootropic Study of the Week", in which David will summarize and interpret the methodologies and findings of researchers of nootropics. In the future, the Nootropic Study of the Week will be included in longer episodes with longer interpersonal conversations as the body of the podcast. Link to this weeks study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5629791/ Nootralize links: * https://nootralize.com - Website * https://soundcloud.com/@nootralize - SoundCloud * https://medium.com/@nootralize - Medium * https://twitter.com/nootralize - Twitter * https://linkedin.com/company/nootralize - LinkedIn