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In this episode of the Glad and Longevity Podcast, Jeff Gladden and Jonathan Roseland delve into the world of biohacking and nootropics. They discuss the inspiration behind Roseland's journey into cognitive enhancement, the quest for effective smart drugs, and the role of nicotine in boosting creativity. The conversation also touches on the importance of a systems biology approach to personal development, emphasizing the need for personalized strategies in optimizing cognitive function and overall health. In this conversation, Jonathan Roseland and Jeff Gladden explore the themes of risk-taking, spirituality, psychedelics, and memory enhancement. They discuss the importance of embracing risk in various aspects of life, the spiritual dimensions of longevity, and the potential benefits of psychedelics for personal growth. Additionally, they delve into effective memory enhancement techniques and the power of the mind in shaping personal agency and identity. For Audience Join the other 20,000+ high-performers getting weekly insights on biological reversal, exponential strategies, and Life Energy optimization→ https://start.gladdenlongevity.com/subscribe If you're ready to measure your 60+ biological ages and build a personalized reversal plan, apply for a discovery call here → https://start.gladdenlongevity.com/apply-now Use code 'Podcast10' to get 10% OFF on any of our supplements at https://gladdenlongevityshop.com/! Takeaways Nootropics can provide instant motivation and clarity. The quest for effective smart drugs is ongoing. Nicotine is recognized as a creativity enhancer. Personal development often requires a systems biology approach. Finding your edge is essential for personal growth. Racetams are a promising class of nootropics. Biohacking can lead to meaningful personal development. Understanding individual biodiversity is crucial in nootropic use. Living young for a lifetime involves taking calculated risks. Systems biology can streamline the process of finding effective nootropics. Finding your edge in life can lead to growth. Embracing risk is essential for learning and joy. Spiritual practices contribute to longevity and well-being. Psychedelics can facilitate profound personal insights. Memory enhancement techniques can significantly improve recall. The mind operates on both conscious and subconscious levels. Self-love and safety are crucial for personal development. Agency over one's life choices is empowering. Engaging in challenging activities keeps the mind sharp. Personal growth often requires stepping outside of comfort zones. Chapters 00:00 Introduction to Biohacking and Nootropics 05:57 The Quest for Smart Drugs 12:05 Nootropics: Instant Motivation and Clarity 17:55 Exploring Racetams and Their Effects 23:45 The Role of Nicotine in Cognitive Enhancement 30:05 Systems Biology Approach to Personal Development 37:27 Riding the Edge: Embracing Risk in Life 45:40 The Spiritual Dimension of Longevity 51:39 Psychedelics and Spiritual Growth 58:32 Memory Enhancement Techniques 01:11:36 The Power of the Mind and Personal Agency To learn more about Jonathan Roseland:Email: jr@limitlessmindset.com Website: https://www.limitlessmindset.com/ Facebook: https://www.facebook.com/limitlessmindset Reach out to us at: Website: https://gladdenlongevity.com/ Facebook: https://www.facebook.com/Gladdenlongevity/ Instagram: https://www.instagram.com/gladdenlongevity/?hl=en LinkedIn: https://www.linkedin.com/company/gladdenlongevity YouTube: https://www.youtube.com/channel/UC5_q8nexY4K5ilgFnKm7naw Gladden Longevity Podcast Disclosures Production & Independence The Gladden Longevity Podcast and Age Hackers are produced by Gladden Longevity Podcast, which operates independently from Dr. Jeffrey Gladden's clinical practice and research at Gladden Longevity in Irving, Texas. Dr. Gladden may serve as a founder, advisor, or investor in select health, wellness, or longevity-related ventures. These may occasionally be referenced in podcast discussions when relevant to educational topics. Any such mentions are for informational purposes only and do not constitute endorsements. Medical Disclaimer The Gladden Longevity Podcast is intended for educational and informational purposes only. It does not constitute the practice of medicine, nursing, or other professional healthcare services — including the giving of medical advice — and no doctor–patient relationship is formed through this podcast or its associated content. The information shared on this podcast, including opinions, research discussions, and referenced materials, is not intended to replace or serve as a substitute for professional medical advice, diagnosis, or treatment. Listeners should not disregard or delay seeking medical advice for any condition they may have. Always seek the guidance of a qualified healthcare professional regarding any questions or concerns about your health, medical conditions, or treatment options. Use of information from this podcast and any linked materials is at the listener's own risk. Podcast Guest Disclosures Guests on the Gladden Longevity Podcast may hold financial interests, advisory roles, or ownership stakes in companies, products, or services discussed during their appearance. The views expressed by guests are their own and do not necessarily reflect the opinions or positions of Gladden Longevity, Dr. Jeffrey Gladden, or the production team. Sponsorships & Affiliate Disclosures To support the creation of high-quality educational content, the Gladden Longevity Podcast may include paid sponsorships or affiliate partnerships. Any such partnerships will be clearly identified during episodes or noted in the accompanying show notes. We may receive compensation through affiliate links or sponsorship agreements when products or services are mentioned on the show. However, these partnerships do not influence the opinions, recommendations, or clinical integrity of the information presented. Additional Note on Content Integrity All content is carefully curated to align with our mission of promoting science-based, ethical, and responsible approaches to health, wellness, and longevity. We strive to maintain the highest standards of transparency and educational value in all our communications.
As Biohackers, we are perpetually on the hunt for the "thrust"--that elusive, boundless well of energy and motivation required to kick ass through the day. We obsess over stimulatory molecules, the latest Racetams, and those "limitless" compounds that promise to keep our cognitive engines revving. But any seasoned practitioner of the art of human optimization knows that this high-octane lifestyle requires a counterbalance.If you aren't prioritizing the quality of your downtime, you are effectively redlining your engine without ever changing the oil. I've recently been experimenting with a specific stack of anxiolytic sleep supplements and biohacking tech that has resulted in some seriously solid, restorative slumber. It's time we acknowledge a fundamental truth often ignored by the "hustle culture" mainstream: Sleep is, in itself, a potent Nootropic.Read more
Hello, everyone, welcome to this episode posted exactly on time where Sarah and Cyrus discuss the romance series of the moment, The Gay Hockey One That Now Has a TV Show. But first, 13 minutes of bullshit. We really make you wait for it. And we also spend a lot of time on Game Changers, the first book in the series which Sarah read and Cyrus didn't. You know how bad books sometimes demand conversation more than good ones? Also. Sweat. We discuss a lot of sweat. My dudes, this episode is all over the place. Enjoy?Support the show
Iron Radio: Strength Sports, Nutrition, and Latest Research InsightsWelcome to Iron Radio with hosts Phil Stevens, Dr. Lonnie Lowery, and Dr. Mike T. Nelson. In this episode, we delve into the latest research in strength sports and sports nutrition. Topics include a study evaluating the effects of minimally processed red meat on cognitive and physical aging, potential health risks of the ketogenic diet based on a long-term mouse study, and the emerging benefits of silk peptides for cognitive function. Stay tuned for insights, debates, and practical advice on optimizing your nutrition and training!00:47 Newsletter and Certification Announcements01:38 News Segment: Red Meat and Health02:01 Study Analysis: Red Meat and Plant-Forward Diets05:25 Discussion on Red Meat and Lean Mass11:36 News Segment: Keto Diet Health Risks19:41 Iron Radio Updates and Announcements21:48 Introducing the New Book on Dietary Supplements22:39 Upcoming Editorial on Sports Nutrition23:18 Exploring Silk Peptides for Cognitive Health24:02 Mechanisms and Benefits of Silk Peptides29:49 Practical Applications and Personal Experiences32:09 Challenges in Cognitive Supplement Research41:31 Future Directions and Final Thoughts Donate to the show via PayPal HERE.You can also join Dr Mike's Insider Newsletter for more info on how to add muscle, improve your performance and body comp - all without destroying your health, go to www.ironradiodrmike.com Thank you!Phil, Jerrell, Mike T, and Lonnie
An aspirational sex-hacker asks: "Any advice to come faster? That's my problem, actually..." I answer that, address some Biohacking questions, and address the fundamental philosophical question, "Why would a good God allow bad things to happen to good people?"9:03 How can men come faster during sex?32:18 Does Piracetam increase sex drive?33:16 How much do they pay you to advertise Nootropic products?35:28 What Nootropics are best for focus and communication?39:00 Does Adrafinil differ from Modafinil?41:32 MAOI alternatives to Selegiline?44:45 Why does "The Programmer" let bad things happen to good people?Read
I perused hundreds of Piracetam users' reports and came across a statistically significant number of anecdotal reports of people who used Piracetam for a while and experienced some transformational benefits to their intelligence, BUT when they discontinued the use of the Smart Drug, there was an unmistakable deficit in their cognitive abilities. 10% - 15% of anecdotal reports mention this Post-Piracetam Intelligence Deficit. I have a couple of explanations for this...Read Meta-Analysis
Two questions I get a lot from people who are new to Biohacking and cognitive enhancers are...❓ Which Smart Drugs actually work and have science behind them?❔ Which Nootropic should I get started with?⚡ My answer to both questions is the same: PiracetamIt has a significant body of scientific evidence behind it; over 750 human studies and academic papers have been published about Piracetam on PubMed, with over ten meta-analysis papers in just the past decade.9:51 Scientific Research11:52 Memory Enhancement17:50 Mitochondrial Nootropic19:47 Stroke Recovery20:12 Cognitive Enhancer20:50 Verbal Fluency22:45 Cognitive Decline24:26 Vs Alzheimer's24:53 Mechanism of Action26:42 History27:13 Vs Depression29:50 Sources35:43 Piracetam Non-Responders?37:10 Tolerance37:28 Post-Piracetam Intelligence Deficit43:09 Addiction or Dependence?43:50 Experiential46:47 Featured in Fiction47:21 Dosage & Cofactors49:22 Side Effects & Risks56:23 ConclusionRead Meta-Analysis
Sarin – “Paradise”, 2020. JG Outsider – “Two Black (Skelesys Remix)”, 2022. PVA – “Sleek Form”, 2020. Siarem – “Alienated”, 2022. Leæther Strip – “Don’t Crash”, 2020. Nootropic – “Re_Spawn”, 2020. Covenant – “Lightbringer (Speedrun)”, 2010. Winter Severity Index – “Another Woman”, 2022. Ghost Cop – “Softer Than Spoken”, 2020. Kompromat – “Niemand”, 2019. Komputer – “Looking Down on London (Metroland)”, 1997. New Order – “Ruined in a Day (K-Klass Remix)”, 2005. Normal Bias – “Stuck in the Past”, 2022. Under Noise – “Sun”, 1997. Website link: https://skullandcrossfades.com/diving-further-down-into-hell
Want to improve memory, unlock neuroplasticity, and achieve sharper brain optimization? This episode reveals how Transcendental Meditation (TM) functions as one of the most powerful nootropics for human performance, longevity, and resilience. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with neuroscientist and physician Dr. Tony Nader, the global leader of the Transcendental Meditation movement. With an MD and PhD from MIT and Harvard, Dr. Nader bridges hard science with ancient wisdom, showing how TM measurably changes brainwaves, boosts mitochondria, and even slows biological aging. His research connects meditation to reduced stress, faster reaction time, and improved memory, giving listeners cutting-edge tools for smarter not harder living. You'll Learn: • How Transcendental Meditation induces high-coherence alpha brain states that improve clarity, focus, and resilience • Why TM increases blood flow to the prefrontal cortex and supports memory, decision-making, and creativity • How meditation measurably reduces biological age by 5–10 years through stress reduction and physiological balance • Why reaction time and situational awareness improve immediately after meditation — even used by fighter pilots • How TM differs from mindfulness or concentration practices at the brainwave level (alpha vs. theta vs. gamma) Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday, Thursday, and Friday (audio-only) where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. Keywords: Transcendental Meditation benefits, Tony Nader MIT neuroscientist, TM brainwaves alpha coherence, Meditation and neuroplasticity, Default mode network meditation, Meditation and mitochondria, TM and biological age, Consciousness and quantum field theory, Meditation vs psychedelics, Meditation and intuition training, Meditation and dopamine, TM reaction time studies, Hippocampus meditation memory, TM and functional medicine, Meditation and metabolism, Meditation and PTSD recovery, TM for sleep optimization, Meditation and fasting stack, TM and human performance, Meditation and longevity research Thank you to our sponsors! Business of Biohacking Summit | Apply to The Business of Biohacking Summit https://businessofbiohacking.com/. fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE. Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order. Resources: • Tony's Website: https://drtonynader.com/ • Danger Coffee: https://dangercoffee.com/DAVE15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Trailer 1:47 — Intro 2:57 — Transcendental Meditation 3:56 — States of Consciousness 10:16 — Brainwaves & Practice 18:35 — Science Bias 38:07 — Mind & Reality 50:32 — Psychedelics & TM 54:29 — Brain & Body Effects 59:31 — Daily Practice 1:02:43 — Closing Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Reverse the signs of aging with red light therapy. Get 15% off Bon Charge with code WENDY at https://boncharge.com Nicotine has been painted as harmful and addictive for decades, yet research shows it may be one of the most misunderstood nutrients in modern health. From its anti-inflammatory effects to its ability to resolve long COVID symptoms in days, the real story is not what we've been told. Today, I sit down with Dr. Bryan Ardis to uncover the science behind nicotine, why it has been vilified by medicine and big pharma, and how it supports brain health, immunity, inflammation, and even chronic conditions like Alzheimer's, Parkinson's, arthritis, and digestive disorders. We also explore why future pandemics are being framed the way they are, what nicotine has to do with viral resistance, and how to safely use it through foods or patches. If you've struggled with long COVID, chronic inflammation, brain fog, or want to understand the lies around nicotine and salt that may be keeping you unwell, this episode is for you. “ Nicotine is the antidote to all viruses, and this is why they can't let nicotine be circulated and be allowed to be bought over the counter.” ~ Dr. Bryan Ardis In This Episode: - Dr. Ardis's background and work - Research linking nicotine to long COVID recovery - Why do governments want nicotine banned? - The real definition of viruses and the role of venom - Nicotine in foods like nightshades, potatoes, and tomatoes - Nicotine is not addictive: Pyrazines are the culprit - Nicotine's broader health benefits - Nootropic effects and brain fog relief - Dosage protocols for patches and gum - Recommended nicotine companies - Who should never try nicotine? - The importance of minerals and salt for health Products & Resources Mentioned: Bon Charge Red Light Face Mask: Save 15% sitewide with code WENDY at https://boncharge.com Qualia Senolytic: Get 15% off with code WENDY at https://qualialife.com/wendy Heavy Metals Quiz: Start now at https://heavymetalsquiz.com About Dr. Bryan Ardis: Dr. Bryan Ardis is a retired chiropractor, acupuncturist, and nutritionist who has become one of the most recognized voices in exposing medical lies and advocating for natural healing. After personal tragedy during the COVID-19 hospital protocols, he dedicated his life to sharing hidden truths about medicine, pharmaceutical agendas, and holistic solutions. He is the bestselling author of Moving Beyond the COVID-19 Lies, host of The Dr. Ardis Show, and co-founder of Healing for the Ages, a global platform educating people on natural health and toxin-free living. Learn more at https://thedrardisshow.com and https://healingfortheages.com Disclaimer The Myers Detox Podcast was created and hosted by Dr. Wendy Myers. This podcast is for information purposes only. Statements and views expressed on this podcast are not medical advice. This podcast, including Wendy Myers and the producers, disclaims responsibility for any possible adverse effects from using the information contained herein. The opinions of guests are their own, and this podcast does not endorse or accept responsibility for statements made by guests. This podcast does not make any representations or warranties about guests' qualifications or credibility. Individuals on this podcast may have a direct or indirect financial interest in products or services referred to herein. If you think you have a medical problem, consult a licensed physician.
Today we're talking about something every woman deserves straight talk about—perimenopause and menopause and the many changes that happen as estrogen and progesterone begin to decline. If you want to support what we do, head over to our Partners Page. You'll find some amazing brands we trust—and by checking them out, you're helping us keep the podcast going. Now, most of us have heard about hot flashes, but very few people explain what's actually happening inside our bodies, why it's happening, and what we can do to feel better. And yes, that includes some really interesting therapies like peptides. What is happening? Let's start with the transition itself. Perimenopause is that phase leading up to menopause, which is officially defined as twelve months without a menstrual cycle. It usually starts in your 40s, though some women notice changes earlier. The reason it can feel like a rollercoaster is all about hormones. Estrogen is our multitasker—keeping our bones strong, our skin glowing, our brains sharp, and even helping with vaginal lubrication. When estrogen dips, it's not surprising that hot flashes, vaginal dryness, and mood swings start showing up. Progesterone, on the other hand, is what I like to call our “chill hormone.” It helps us sleep and keeps our cycles balanced. When progesterone drops, insomnia, irritability, and mood swings can sneak in. And let's not forget testosterone, which fuels energy, muscle, and libido. As testosterone slowly declines, it's no wonder sex drive can take a hit. When these three hormones are fluctuating or dropping during perimenopause, it can touch nearly every part of the body, making this phase feel intense and, at times, overwhelming. Brain fog Then there's brain fog. You know, that feeling when you walk into a room and can't remember why you're there. Estrogen actually plays a big role in keeping our brain sharp by influencing neurotransmitters like acetylcholine, which manage memory and focus. When estrogen levels fall, those neurotransmitters aren't as efficient, and poor sleep from night sweats can make brain fog even thicker. What helps? Regular exercise, consistent sleep, omega-3s, and even brain-training games can make a difference. And peptides can play a role here too. Nootropic peptides like Selank and Semax support neurotransmitter balance, helping with focus, memory, and mental clarity, while also helping the brain manage stress and fatigue. Weight gain Let's talk about one of the biggest frustrations women bring up during perimenopause and menopause—weight gain. You may notice that even if you're eating the same and moving your body the way you always have, the scale starts creeping up. This isn't your imagination. As estrogen levels drop, metabolism slows down, muscle mass tends to decrease, and fat starts redistributing—especially around the belly. On top of that, poor sleep, more stress, and shifting insulin sensitivity can all make it harder to keep weight steady. The good news is there are ways to manage this. Resistance or strength training helps preserve and even rebuild muscle, which keeps your metabolism active. Prioritizing protein with every meal can support that muscle, too. Managing stress through mindfulness, yoga, or simply better boundaries can help with cortisol—the stress hormone that encourages belly fat storage. And paying attention to blood sugar balance, by choosing more whole foods and fewer processed carbs, can really make a difference. For some women, hormone therapy can provide extra support by improving sleep, mood, and metabolism, making it easier to maintain a healthy weight. And now, we also have GLP-1 agonists—like semaglutide—and even newer dual GIP/GLP-1 agonists, such as tirzepatide. These medications work by improving satiety, slowing digestion, balancing blood sugar, and supporting insulin sensitivity, all of which can make weight management during menopause more achievable. They're not magic, but when combined with lifestyle changes, they can be powerful tools to help women feel more in control of their weight and overall health during this stage of life. Hair changes Hair changes are another big one. Estrogen helps keep hair thick, strong, and healthy by promoting follicle growth and prolonging the growth phase. When estrogen drops, hair can start thinning. At the same time, shifts in androgen levels like testosterone and its potent form, DHT, can trigger hair growth in places we really don't want it, like the chin or upper lip. Collagen supplements, checking iron and vitamin D levels, stimulating the scalp, or even low-level laser therapy can all support healthier hair. Peptides like GHK-Cu, a copper peptide, stimulate hair follicles by promoting cell growth, increasing blood supply, and supporting collagen production. Thymosin Beta-4, or TB-500, also helps by reducing inflammation and encouraging tissue repair, creating a better environment for hair growth. Skin changes As estrogen dips, natural moisture throughout the body also decreases. This can mean dry eyes, crepey or itchy skin, and new sensitivities popping up seemingly out of nowhere. Support can be as simple as artificial tears, omega-3s to support tear production, gentle fragrance-free moisturizers, or running a humidifier at night. Peptides like Epitalon reduce oxidative stress, support collagen production, and promote cellular repair, which can improve skin elasticity. BPC-157 helps reduce inflammation and supports healing, making the skin less reactive and more comfortable. Bladder issues And then there are those bladder surprises. Ever sneeze, laugh, or cough and suddenly wonder if you should've packed a spare pair of underwear? Dropping estrogen weakens the pelvic floor and thins the bladder lining, which can make those little “oops” moments more common. Kegel exercises, pelvic floor physical therapy, vaginal estrogen creams, and avoiding bladder irritants like coffee or alcohol can help. Peptides like BPC-157 support tissue healing in the bladder and pelvic area, and KPV may help calm irritation in urinary tissues. Mood changes Mood changes are another challenge. Shifts in estrogen, progesterone, and serotonin can trigger anxiety, irritability, or low mood seemingly overnight. Things like therapy, mindfulness, regular exercise, and making sure you get enough vitamin D and magnesium can really help. Peptides give an extra boost too. Selank is a gentle anti-anxiety peptide that won't make you drowsy, DSIP (Delta Sleep-Inducing Peptide) helps improve deep sleep, naturally stabilizing mood, and Semax works on dopamine pathways to lift energy, focus, and motivation when you need it most. Sex drive Finally, let's talk about something we don't discuss enough: libido. Vaginal dryness, fatigue, and shifting hormones can all make desire dip, and this is very much physiological, not just in your head. Lubricants, vaginal moisturizers, hormone replacement therapy, and open communication with your partner can all help. Peptides like PT-141 (bremelanotide), work on melanocortin receptors in the brain to boost sexual desire. It's an on-demand injection, usually taken a few hours before intimacy, and many women feel it helps restore that spark that seemed long gone, though side effects can include flushing or nausea. So here's the big takeaway: menopause is much more than hot flashes. It's brain, body, skin, mood, and sexual function all shifting at once. But you don't have to just “tough it out.” From lifestyle shifts to targeted peptides, there are tools to help you feel like yourself again. And the most important thing to remember is that you are not alone. Every chin hair, every laugh-leak, every brain fog moment—you've got millions of women nodding right along with you. Thanks for listening to The Peptide Podcast. If today's episode resonated, share it with a friend—because if she's in her 40s or 50s, she's probably going through the same changes and wondering if she's the only one. And if you want to support what we do, head over to our Partners Page. You'll find some amazing brands we trust—and by checking them out, you're helping us keep the podcast going. Until next time, be well, and as always, have a happy, healthy week.
What if the most powerful upgrades for brain energy, metabolism, and drive aren't in mainstream medicine, but in rare peptides and misunderstood hormones? In this episode, you'll discover the cutting-edge compounds, nootropics, and hormonal strategies that elite biohackers are using right now to optimize every part of their biology. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Jay Campbell and Hunter Williams, co-founders of BioLongevity Labs—a performance biotech company creating oral peptide-based products like BioMind and BioGutPro. Jay is a globally recognized expert in testosterone optimization, author of The TOT Bible, and a leading voice in hormone and peptide therapeutics. Hunter is a high-performance coach and podcast host focused on metabolism, mindset, and men's health through functional medicine and advanced supplementation. In this high-energy, high-clarity conversation, the trio explore what's working right now in advanced human performance, spanning hormone synergy, mitochondrial enhancement, libido compounds, nootropics, and muscle-preserving stacks. You'll hear why Dave injects estradiol three times per week, how Jay and Hunter use oral bioregulators to improve gut-brain signaling, and what peptides are quietly reshaping the future of health. You'll Learn: • Who should use estradiol—and how it can protect brain performance in men • The real role of testosterone and estradiol synergy in male health and longevity • How BioLongevity Labs is innovating with oral peptide delivery for cognitive and gut health • Why peptides like BPC‑157, TB‑500, PT‑141, and SS‑31 are changing mitochondrial care • The truth about Melanotan‑1, SLU, AOD‑9604, GW‑501516, and BAM‑15 • What makes BioMind and BioGutPro different from standard nootropic or probiotic stacks • Why libido and metabolic health are deeply connected • The dangers of unvetted peptide sources—and what to look for in quality and bioavailability This is essential listening for anyone serious about biohacking, hormone optimization, mitochondrial support, brain energy, nootropics, neuroplasticity, functional medicine, sleep optimization, metabolism, and smarter-not-harder living. Keyword Index: estradiol for men, Dave Asprey hormone therapy, Jay Campbell BioLongevity Labs, Hunter Williams performance coaching, BPC‑157 recovery peptide, TB‑500 tissue regeneration, PT‑141 libido peptide, SS‑31 mitochondria peptide, Melanotan‑1 for skin and mitochondria, SLU stack, AOD‑9604 fat loss peptide, GW‑501516 Cardarine, BAM‑15 mitochondrial uncoupler, oral peptide delivery, BioMind brain supplement, BioGutPro gut-brain axis, testosterone estradiol synergy, mitochondrial uncoupling, nootropic peptide stacks, performance biohacking supplements Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday, Thursday, and Friday where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. Thank you to our sponsors! Puori | Head to http://puori.com/dave for 20% off, including subscriptions. Leela Quantum Tech | Head to https://leelaq.com/DAVE for 10% off. ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order. Resources: • BioLongevity Labs Website: https://biolongevitylabs.com/?ref=DAVE# • Dave Asprey's Website: https://daveasprey.com • Danger Coffee: https://dangercoffee.com/DAVE15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 00:00 – Trailer 01:00 – Introduction & Early Days of Biohacking 02:03 – Peptides 101: Foundations and Frameworks 03:06 – Peptides for Healing, Cognition, and Longevity 07:56 – Bioregulators and Russian Innovations 11:07 – Side Effects and Safety of Peptides 22:27 – Oral Peptides and Product Innovations 27:41 – Body Composition, Hormones, and Fat Loss 32:02 – Testosterone, Estrogen, and Male Health Protocols 45:03 – Peptides for Performance, Fat Loss, and Longevity 1:26:32 – Loose Skin, Surgery, and Body Transformation 1:38:00 – Closing Thoughts & Product Recommendations See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Get My Book On Amazon: https://a.co/d/avbaV48Download The Peptide Cheat Sheet: https://peptidecheatsheet.carrd.co/Download The Bioregulator Cheat Sheet: https://bioregulatorcheatsheet.carrd.co/
What if one spray could upgrade your brain, protect your mitochondria, and outperform IV therapy and liposomal supplements? In this episode, you'll discover the breakthrough science behind topical glutathione delivery that uses your skin's water channels to raise intracellular glutathione levels in just 60 seconds. Learn how this powerful antioxidant works at the cellular level to reduce oxidative stress, support mitochondrial function, and drive real improvements in brain health, emotional resilience, and human performance. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Nayan Patel, a world-leading pharmacist and formulator who pioneered this next-gen delivery method. With over two decades of clinical work in functional medicine, Nayan has helped reshape how we think about glutathione benefits, systemic detox, and performance optimization. His research shows that topical delivery bypasses traditional fat-based absorption, achieving higher brain uptake and faster results than IVs or capsules. You'll learn: • Why glutathione for longevity is foundational to biohacking • How it protects against cellular inflammation and improves TBI recovery issues • Why pairing glutathione with NAD+, vitamin C, or pharmaceutical nicotine creates a powerful synergy • How it preserves NAD+, supports sirtuins, and enhances ATP production • When to use glutathione as an immune booster for resilience and recovery This conversation also reveals the truth behind liposomal supplements, how your age affects glutathione absorption, and why this molecule is critical for anyone using nootropics, in ketosis, or pushing metabolic limits. This episode is essential listening for anyone into biohacking, cold therapy, functional medicine, or RFK-style medical freedom. You'll walk away with practical tools to boost nitric oxide naturally, prevent dysfunction, and optimize your biology whether you're on a carnivore diet or just looking for an edge. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. Resources: • Auro Wellness Website: Use code ‘dave10' at checkout https://aurowellness.com/ • Dave Asprey's Website: https://daveasprey.com • Danger Coffee: https://dangercoffee.com/DAVE15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: • 00:00 Trailer • 00:20 Intro • 01:12 Water Channel Delivery Explained • 02:25 What Makes Glutathione Special • 05:04 Why IVs and Liposomes Fail • 06:29 Measuring Glutathione in the Brain • 10:42 Key Benefits and Use Cases • 20:49 Emotional Resilience Effects • 23:54 Sensitivity and Response • 24:55 Best Timing for Use • 25:53 Workout Performance Boost • 26:47 Brain Health and TBI Support • 28:22 Best Stack Combinations • 29:32 Nicotine + Glutathione Synergy • 33:18 Longevity, Sirtuins, and Genes • 40:36 Glutathione as Immune Booster • 43:15 Peptides and Next-Gen Hacks • 45:29 Dosing Tips and Wrap-Up See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
In this powerful episode of the Metabolic Freedom Podcast, Ben Azadi sits down with Miesha Tate, a UFC World Champion, biohacker, and wellness advocate, to explore the intersection of science and intuition in health and performance. Miesha shares her journey from elite fighter to holistic wellness enthusiast, revealing the biohacking strategies, recovery tools, and mindset shifts that have transformed her health.
Brian Sanchez, a 365 lb genetic freak who was already 6 feet tall, underwent limb-lengthening surgery to increase his height to 6'6”. For the first time ever he reveals the raw, unfiltered reality of the procedure, the excruciating pain, the grueling recovery, and the mental warfare of reshaping his own body. This is the ultimate deep dive into one of the most extreme body transformations ever attempted. ————————————
Will's channel and corresponding video: https://youtu.be/cuE5VHQYZoo?si=AcAU9Qxtqs-l-BS-
In this episode of The Art of Being Well, Dr. Will Cole is joined by Dr. Gregory Kelly, SVP of Product Development at Qualia Life and expert in nootropics, anti-aging, and cognitive health. Dr. Kelly breaks down the concept of mental energy as a finite resource, explaining why it depletes and how to restore it. He explores the rise of neuroinflammation, the role of nootropics in brain health, and the science behind stacking ingredients for optimal mental performance. Plus, Dr. Kelly shares insights from Dr. Heather Sandison's study on cognitive health, offering practical strategies to improve focus, memory, and overall mental vitality. For all links mentioned in this episode, visit www.drwillcole.com/podcast.Go to qualialife.com/WILL and use code WILL to get an additional 15% off any Qualia order.Please note that this episode may contain paid endorsements and advertisements for products and services. Individuals on the show may have a direct or indirect financial interest in products or services referred to in this episode.Sponsors:Go to qualialife.com/WILL for up to $100 OFF Qualia Mind, and as a listener of The Art of Being Well use code WILL at checkout for an additional 15% off any purchase. For your convenience Qualia Mind is also available at select GNC locations near you. Take proactive care of your health and head to OPositiv.com/WILLCOLE or enter WILLCOLE at checkout for 25% off your first purchase.Listeners of The Art of Being Well can claim an exclusive three-month free trial, with no credit card required at www.YNAB.com/willcole.Go to fromourplace.com and enter my code WILLCOLE at checkout to receive 10% off site wide.Produced by Dear Media.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Wellness + Wisdom | Episode 708 What if the secret to limitless energy and a purposeful life lies in the right supplements? Jeff Boyd, Founder of MTE, joins Josh Trent on the Wellness + Wisdom Podcast, episode 708, to reveal the secrets to building lasting habits, how to unlock limitless energy with natural solutions, why nootropics are a healthier and more sustainable source of energy compared to caffeine, and how to live a life of purpose while breaking free from the traps of modern life. "Saffron is 21 times more expensive than any other ingredient in the MTE formula. If it weren't that expensive, it would be the #1 supplement in the country, if not the world. It's decreasing anger, confusion, depression, increasing vigor, and then improves your sleep." - Jeff Boyd Get MTE with 20% Off MTE is a science-backed blend of superfoods, nootropics + adaptogens that support whole-body health. Replace excessive caffeine to supercharge energy, wellness, and recovery. Energy: A dynamic nootropic blend supports jitter-free energy without the caffeine crash you get from coffee and energy drinks. Focus: Packed with ingredients like teacrine and l-theanine to support peak performance and focus. Mood: Adaptogens and nootropics like saffron and holy basil support mood and stress response. Recovery: Adaptogens support stress response, which helps support more natural energy reserves during the day and recovery at night. Get 20% off with code "JOSH" In This Episode, Jeff Boyd Uncovers: [01:30] The Key to Wellness Jeff Boyd MTE: 20% off with code "JOSH" Why feeling good is the basis of wellness. How telling people not to do something will make them do it. Why the current environment and lifestyle are making us sick. How sleep is needed for the mind to relax. [07:55] More Than Energy Why Jeff named his company "More Than Energy." How alcohol affects the quality of sleep. Why energy stimulants keep us in a vicious cycle. How we can adjust our lifestyle choices according to how much of our potential we want to use. [13:05] The Limitless Powder Why people who take MTE lose their appetite for coffee. How the body gradually adjusts to what we put in it on a regular basis. Why the quick fix only treats the symptom but not the cause. [17:40] Why New Year's Resolutions Don't Last Why it's easier to add things in than to take them out. What makes people abandon their New Year's resolutions. Why gyms get 80% of their revenue from people who don't go to the gym. [22:15] Don't Let One "Fail" Define Your Success Why people are interested more in getting inspired by personal experiences than proven methods. How many people give up new habits when they think they failed. What we do most of the time defines us more than what we do just a few times. Why Jeff started his first business when he was very young. [28:05] How to Create New Habits 192 Jason Prall: The Human Longevity Project How belief in higher power is the key to longevity. The five Blue Zones have one food in common. Why new activities take 90 days to become habits. [33:20] Live a Life of Purpose Why living a life of purpose gives us more energy. How working on our dreams involves doing the things we don't want to do. Why we shouldn't choose a career only based on how much money we'll make. [38:00] What Is It That Makes You Itch? Why success has very little to do with money. How Jeff's daughter realized she should focus on the things she loves. Why pursuing happiness feels scary. How successful people remind us what's possible. [43:20] The Key to Success Why our identity serves as a mirror that reflects back to us who we are. How people who value stability and predictability usually don't start a business. Why it's easier to sell someone else's product. How other people's behavior towards us has nothing to do with us. [48:55] Do You Love Yourself? Why we don't know how to love ourselves. The Omnivore's Dilemma by Michael Pollan Why it's important to celebrate the small wins. When we focus on the end goal, we miss everything else that happens before we reach it. [56:10] Healing The Scarcity Mindset How death reminds us to live. Why Jeff was miserable when he was grinding and focusing on growing the business. How our priorities define us. Why more money doesn't mean more problems. [01:00:45] Why MTE? Why some people are more sensitive to caffeine. How the ingredients in MTE support our energy levels. Why paraxanthine builds up the adrenal glands instead of exhausting them. [01:05:55] Caffeine Replacement The Psychic Roots of Disease by Bjorn Eybl Why the liver collects anger. How caffeine alters our mood. Why saffron helps decrease anger. How Jeff got gout from eating too much kale. Why a carnivore diet is out of balance. [01:13:25] The Healing Power of Saffron Why saffron would be used more if it wasn't that expensive. The benefits of taking saffron. How the gut impacts the brain. Why there's no technology that's more intelligent than the gut. [01:20:55] Going Back to Nature + Community Yellowstone (2018) Why we need supplements if we live out of harmony with nature. What was Jeff's experience living in New York and Miami. How living in Texas has provided a better quality of life. Why being in a community makes us happier. [01:27:15] What You Consume Matters How we can make ourselves less monetizable. Why we should be conscious of what content we consume. How Jeff's teaching his daughter to not be on her phone when she's having a conversation with someone. [01:33:10] The Benefits of Nootropics Why quick energy fixes don't work in the long run. How caffeine gives us energy but doesn't allow us to use it properly. Why paraxanthine provides better mood, blood flow, and focus. How nootropics are full-spectrum rather than single-use. Leave Wellness + Wisdom a Review on Apple Podcasts Power Quotes From The Show Caffeine Energy "Not all nootropics are created equal. Caffeine is a nootropic by definition. Particularly what caffeine and energy drinks are missing is they're just giving you energy, but you have no ability to use it properly. They keep you awake but you're miserable." - Jeff Boyd Why Multitasking Is a Myth "Multitasking is a term that was made for computers. Humans cannot multitask. We can shift from one task to another in a nanosecond so it seems like we can multitask, but we are hardwired. We can only do one thing at a time." - Jeff Boyd Paraxanthine Gives You More Than Energy "Paraxanthine gives you smooth energy. It's increasing short-term memory, cognition under physical stress, and the ability to pay attention. That's more than energy. That's being able to have energy to then go deploy it, use it, and be your best self. What's the point otherwise?" - Jeff Boyd Links From Today's Show Jeff Boyd MTE: 20% off with code "JOSH" 192 Jason Prall: The Human Longevity Project The Omnivore's Dilemma by Michael Pollan The Psychic Roots of Disease by Bjorn Eybl Yellowstone (2018) Josh's Trusted Products | Up To 40% Off Shop All Products Biohacking MANNA Vitality - Save 20% with code JOSH20 HigherDOSE - 15% off with the code JOSH15 PLUNGE - $150 off with discount code WELLNESSFORCE Pulsetto - Save 20% with code "JOSH" SaunaSpace - 10% off with discount code JOSH10 Ultrahuman Ring Air - 10% off with code JOSH Wellness Test Kits Choose Joi - Save 50% on all Lab Tests with JOSH Blokes - Save 50% on all Lab Tests with JOSH FertilityWize Test by Clockwize - Save 10% with code JOSH Tiny Health Gut Tests - $20 off with discount code JOSH20 VIVOO Health Tests - Save 30% off with code JOSH SiPhox Health Blood Test - Save 15% off with code JOSH Nutrition + Gut Health Organifi - 20% off with discount code WELLNESSFORCE SEED Synbiotic - 25% off with the code 25JOSHTRENT
Wellness + Wisdom | Episode 708 What if the secret to limitless energy and a purposeful life lies in the right supplements? Jeff Boyd, Founder of MTE, joins Josh Trent on the Wellness + Wisdom Podcast, episode 708, to reveal the secrets to building lasting habits, how to unlock limitless energy with natural solutions, why nootropics are a healthier and more sustainable source of energy compared to caffeine, and how to live a life of purpose while breaking free from the traps of modern life. "Saffron is 21 times more expensive than any other ingredient in the MTE formula. If it weren't that expensive, it would be the #1 supplement in the country, if not the world. It's decreasing anger, confusion, depression, increasing vigor, and then improves your sleep." - Jeff Boyd Get MTE Supplements with 20% Off MTE is a science-backed blend of superfoods, nootropics + adaptogens that support whole-body health. Replace excessive caffeine to supercharge energy, wellness, and recovery. Energy: A dynamic nootropic blend supports jitter-free energy without the caffeine crash you get from coffee and energy drinks. Focus: Packed with ingredients like teacrine and l-theanine to support peak performance and focus. Mood: Adaptogens and nootropics like saffron and holy basil support mood and stress response. Recovery: Adaptogens support stress response, which helps support more natural energy reserves during the day and recovery at night. Get 20% off MTE with code "JOSH" In This Episode, Jeff Boyd Uncovers: (01:30) The Key to Wellness (07:55) More Than Energy (13:05) The Limitless Powder (17:40) Why New Year's Resolutions Don't Last (22:15) Don't Let One "Fail" Define Your Success (28:05) How to Create New Habits (33:20) Live a Life of Purpose (38:00) What Is It That Makes You Itch? (43:20) The Key to Success (48:55) Do You Love Yourself? (56:10) Healing The Scarcity Mindset (01:00:45) Why MTE? (01:05:55) Caffeine Replacement (01:13:25) The Healing Power of Saffron (01:20:55) Going Back to Nature + Community (01:27:15) What You Consume Matters (01:33:10) The Benefits of Nootropics
Hope you guys enjoy this clip from next week's podcast with Peter Attia. We covered a lot of great topics, not just phone books. It goes live next Monday on the MPMD YouTube channel! ————————————
Andrew's Website & New Book: https://www.neverenough.com/ Andrew's Social Media: Twitter: https://x.com/awilkinson YouTube: @NeverEnough2024 Instagram: https://www.instagram.com/awilkinson/ ————————————
Entrepreneur Andrew Wilkinson On His Experience Trying SSRI's For His Lifelong Anxiety, And What Happened To His Mind Afterwards ———————————— Andrew's Website & New Book: https://www.neverenough.com/ Andrew's Social Media: Twitter: https://x.com/awilkinson YouTube: @NeverEnough2024 Instagram: https://www.instagram.com/awilkinson/ LinkedIn: https://www.linkedin.com/in/awilkinson/ ————————————
Andrew's Website & New Book: https://www.neverenough.com/ Andrew's Social Media: Twitter: https://x.com/awilkinson YouTube: @NeverEnough2024 Instagram: https://www.instagram.com/awilkinson/ LinkedIn: https://www.linkedin.com/in/awilkinson/ ————————————