Podcasts about eran elinav

Artificial sweeteners are everywhere. They hide in cereal, salad dressing – even in health foods. But are they really a guilt-free way to satisfy your sweet tooth? Or is it naive to think that – because they're zero calorie – they're free of consequence? New research shows there is a consequence. And it could be massive. Artificial sweeteners may disrupt the delicate balance of bacteria that live in your gut. You could see ripple effects like chronic disease, weight gain and a weakened ability to process real sugar. Today's guest is at the forefront of this research. For the last decade, Dr Eran Elinav led breakthroughs on the science behind popular sweeteners. He leads The Institute for Microbiome Research at the Weizmann Institute of Science. He's published over 100 publications in leading scientific journals. And his lab is on the cutting-edge of gut microbiome research.  We're also joined today by Tim Spector. Tim is one of the world's top 100 most-cited scientists, a professor of epidemiology, and my scientific Co-Founder at ZOE.  You'll finish today's episode knowing what's in your sweetener, how it's affecting you, and where to turn to satisfy your sweet tooth.   

Found My Fitness - Rhonda Patrick Podcast Notes Key Takeaways The way we respond to a diet is highly individualized – people uniquely respond to diet, even if fed the exact same foods“The dominant factor that determines the diurnal activity of microbes throughout the day is the timing of our feeding.” – Dr. Eran ElinavOur gut microbiome senses when we eat or don't eat and changes activity accordinglyChanges in health status, stress status, medication, the way we live, where we live, etc. reflect on our gut microbes and may impact the risk of developing diseasesA leaky gut is related to disease: diverse molecules secreted by the gut microbe are important in creating the normal state of leakiness which allows us to absorb food and block foreign molecules we don't want in our body – when disrupted, there's a strong link to disease (cancer, autoimmune & cardiovascular disease)The success of probiotic supplementation depends on whether the exogenous probiotic is welcomed by endogenous microbes in the gutThe complexity of taking antibiotics and probiotics: giving probiotics together with antibiotics may protect individuals from adverse effects of antibiotics – but the price may be a chronic disturbance in gut microbiome with probiotics taking over and reducing the diversity of the innate gut microbiomeAbout 80% of overweight people who diet will gain back the weight plus some – the microbiome seems to store a metabolic memory of past obesity which predisposes people to exaggerated weight gainBest practices for a healthy microbiome: (1) maintain a consistent, healthy sleep pattern; (2) stop smoking cigarettes; (3) eat during a regular window during the day (avoid night eating); (4) explore wearing a continuous glucose monitor for personalized data; (5) try a personalized nutrition approach (check out Day Two)Read the full notes @ podcastnotes.orgEran Elinav, MD, PhD, is a professor of immunology and principal investigator at the Weizmann Institute of Science in Tel Aviv, Israel, where he co-directs the Personalized Nutrition Project. Dr. Elinav is also a principal investigator at the German Cancer Research Center in Heidelberg, Germany. His research focuses on understanding the complex interactions between humans and the bacteria that reside in their gut and how these interactions shape human health and disease. In this episode, Dr. Elinav and I discuss... 00:06:38 - Circadian rhythm of the microbiome 00:17:17 - Lessons from Hunter-gatherers 00:24:44 - Nurturing the microbiome in children 00:35:16 - Triglycerides and cholesterol 00:38:58 - Saturated fat 00:40:25 - Effect of artificial sweeteners on the microbiome 00:56:10 - What causes recurrent obesity 00:58:17 - Impact of caloric restriction 00:59:26 - Intestinal permeability (gut leakiness) 01:19:54 - Bacteriophage therapy and precision probiotics 01:34:44 - Bacterial role in TMAO risk 01:40:33 - Weight gain from smoking cessation 01:41:53 - Tips for diet personalization Looking for more? Join over 300,000 people and get the latest distilled information on sleep, depression, and fasting straight to your inbox weekly: https://www.foundmyfitness.com/newsletter Try thirty days of our FoundMyFitness premium member to get access to exclusive episodes, emails, a live Q+A with Rhonda and more: https://www.foundmyfitness.com/trial

Eran Elinav, MD, PhD, is a professor of immunology and principal investigator at the Weizmann Institute of Science in Tel Aviv, Israel, where he co-directs the Personalized Nutrition Project. Dr. Elinav is also a principal investigator at the German Cancer Research Center in Heidelberg, Germany. His research focuses on understanding the complex interactions between humans and the bacteria that reside in their gut and how these interactions shape human health and disease. In this episode, Dr. Elinav and I discuss... 00:06:38 - Circadian rhythm of the microbiome 00:17:17 - Lessons from Hunter-gatherers 00:24:44 - Nurturing the microbiome in children 00:35:16 - Triglycerides and cholesterol 00:38:58 - Saturated fat 00:40:25 - Effect of artificial sweeteners on the microbiome 00:56:10 - What causes recurrent obesity 00:58:17 - Impact of caloric restriction 00:59:26 - Intestinal permeability (gut leakiness) 01:19:54 - Bacteriophage therapy and precision probiotics 01:34:44 - Bacterial role in TMAO risk 01:40:33 - Weight gain from smoking cessation 01:41:53 - Tips for diet personalization Looking for more? Join over 300,000 people and get the latest distilled information on sleep, depression, and fasting straight to your inbox weekly: https://www.foundmyfitness.com/newsletter Try thirty days of our FoundMyFitness premium member to get access to exclusive episodes, emails, a live Q+A with Rhonda and more: https://www.foundmyfitness.com/trial

Host and Health: Tailoring Personalized Medicine Using The Unique Microbiome Fingerprint  Professor Eran Elinav from the Weizmann Institute of Science discusses how the interaction between the microbiome and its host is transforming personalized medicine.   “I believe that in the next five to ten years, exploiting the potential of the microbiome will be central to personalized and precision medicine,” explains Eran Elinav. His research into this second genome in the human body at the Weizmann Institute of Science in Isreal is shedding light on how these trillions of cells function and interact with their host. The individualized data from the unique microbiome fingerprint can be harnessed to tailor nutritional therapies to improve metabolic functions in the treatment of, for example, obesity and type 2 diabetes—with a wide range of further potential applications. And even small molecules found within the microbiome could themselves be developed into drugs. The future hope lies in the inherent therapeutic translatability of these insights from host-microbiome interaction research into treating the whole spectrum of metabolic diseases.   Curious to Know More? Listen to the conversation between Lonza's Martina Hestericová and Weizmann Institute of Science Professor and researcher Eran Elinav in this special episode of the "A View On" podcast. KEY TERMS IN CONTEXT: Genome: All of the genetic information of an organism. When speaking about the microbiome, it refers to an entirely different organism that is comprised of its own genetic makeup from the host—the interaction between the two genomes is the subject of study known as host-microbiome interaction. Microbiome: The extremely diverse ecosystem of hundreds, sometimes thousands of different species of microbes found in and on the human body. Microbial biodiversity is key to a healthy microbiome and a poor microbiome is linked to diseases such as inflammatory bowel disease, cancer and possibly some central nervous disorders. Therapeutic translatability: The ability to translate or apply basic research into therapies for the benefit of humans. As we understand more how the complex microbiome works, Professor Elinav asserts that these insights translate directly into ways to manipulate it and improve health. Personalised or Precision Medicine: A general trend to adapt treatments to individuals instead of a one-size-fits-all approach. In the context of host-microbiome research, as the microbiome is unique to each individual, it could hold the keys to specialized treatments by harnessing the individualized data.

Today on our Special Nutrition Therapy Series I’m talking with Dr. Eran Elinav about a personalized approach to glycemic management, weaving together two of my favorite topics--blood sugar balance and individualized nutrition. Dr. Elinav’s research illuminates the physiological importance of embracing the truth that one-size-fits-all rarely works when it comes to dietary recommendations and outcomes. Tune-in and allow Dr. Elinav’s findings to inform your clinical successes! Click here to download the completed Matrix from this week’s episode Click here for Dr. Elinav's publication on Personalized Nutrition by Prediction of Glycemic Responses Check out this fun animation of Dr. Elinav and his colleagues’ research To learn more about the Personalized Nutrition Project Click Here Click here to get your hands on Dr. Elinav’s book ‘The Personalized Diet’ Get 15-Minute Matrix podcast notifications delivered to your inbox!

Metabolic conditions like diabetes are on the rise, and the need for blood sugar management is critical. In this episode, Dr. Eran Elinav shares the science behind a new test that predicts your personal sugar level rise to foods, based on data from your microbiota, blood, body composition, and other clinical details. In the research, the personalized diet generated by the algorithm was slightly more effective in balancing blood sugar than following a diet created by an expert. Learn more about what steps you can take! (Plus, hear details on the first-ever vaginal microbiome transplant.) https://drruscio.com/?p=48739 My book Healthy Gut, Healthy You is available at https://drruscio.com/getgutbook/ Looking for more? Check out https://drruscio.com/resources

Lihi Segal explains how microbiomes are the key to health! I first heard about heard Lihi Segal in a TED Talk about how our diets are unique to our bodies. It was so interesting. It's not about how much we eat, it's the precise mix of foods we consume. I reached out to Lihi and DayTwo, her research company that's developing this new approach, to see if they would share with us their research findings and what it might mean for each of us. The implications of this new understanding of nutrition are enormous. What if we all could be healthier and avoid disease if we better understood what's good and bad for our individual bodies? This is big. Listen in, learn and share this conversation! It could change your life. Perhaps it is time to think about not A DIET but YOUR DIET Lihi Segal is CEO and co-founder of DayTwo, a leader in the development of microbiome-based precision medicine, focusing on metabolic disease. For those of us who don't know, your gut microbiome is the collection of all the microbes (around 100 trillion) that exist in your digestive tract and help you digest food. Your microbiome is unique to you, and influences the way your body reacts to different foods. A new frontier in medicine A study conducted in 2015 at the Weizmann Institute of Science in Israel and published in Cell was the catalyst that got Lihi into the field of personalized, microbiome-based diet solutions. The study, which for one week continuously monitored blood sugar levels in over a thousand people, revealed that the bodily response to foods was highly individual.  Called the Personalized Nutrition Project, the study was led by Professors Eran Segal of the Computer Science and Applied Mathematics Department and Eran Elinav of the Immunology Department. They decided to look at why diets fail and why one person can eat, say, bread and another person can't. Segal and Elinav decided that perhaps the whole approach is wrong and instead of looking at the food, we need to look at the person. This led them to develop an algorithm that collects a person's health data and then predicts which foods and meals would be good for them and which would be bad, with "good" being a meal that doesn't spike blood sugar levels after eating it.  Prof. Segal said: “We chose to focus on blood sugar because elevated levels are a major risk factor for diabetes, obesity and metabolic syndrome. The huge differences in the rise of blood sugar levels among different people who consumed identical meals highlights why personalized eating choices are more likely than universal dietary advice to help people stay healthy.” It's all about your gut microbiome What caught Lihi's attention was the ability of Segal and Elinav's technology to customize low blood sugar level diets for each individual, something very new in the nutrition realm, so her company licensed it. If she could help people avoid disease, and death, Lihi was in.   Researchers at DayTwo then built a mathematical predictive model app that tells you how your blood sugar is going to respond to any meal you eat. Based on that model, they now can create customized diets for their clients so they can successfully avoid high blood sugar levels that cause energy dips, excessive hunger, weight gain and increased risk of obesity and diabetes. As part of their program, they also provide suggested meals, snacks and the services of a dietician. Along these same lines, recent research has shown that your genetic background is not as influential in your microbiome as you might have thought. It is less genetics than a reflection of the people you live with, the foods, drugs and drinks you consume, and your lifestyle. That's why DayTwo's assessment methodology is so innovative—it helps you identify the right diet for your personal “gut.” Think about the implications of this approach Your health to a very large extent stems from how your body processes food. The trillions of bacteria that live in your gut, which differ greatly from person to person, are part of how you uniquely respond to food. Different people have different blood sugar responses to the same foods, which is why it is essential to understand what your particular body needs—and to eat accordingly.  Wanting to bring this groundbreaking technology from Isreal to the U.S., Lihi and DayTwo helped the Mayo Clinic replicate the Weizmann Institute trial which got the same results. Heidi Nelson, M.D., director of the Mayo Clinic Center for Individualized Medicine Microbiome Program, explains:  “We have long wondered why one diet works for one person, but not another. Now, we are beginning to understand that how a person processes food depends upon that individual’s gut microbiome, immune system and the community of bacteria in the gut. Given these multiple factors, we are exploring ways to develop customized diets that will maintain wellness and prevent the development of disease." Nelson adds: "Glucose levels are abnormally high in patients with diabetes, and traditional interventions to control glucose levels have had limited benefit for them. These study results highlight the important role that personalized diets can play in maintaining better control over blood glucose levels and overall health." How do you get started with DayTwo? As Lihi tells us in the podcast, just go to DayTwo's website and order your home testing kit online, which contains everything you need. In addition, over 200 clinics in the U.S. have signed up with her program. Better health is actually attainable for all of us. Some background on Lihi Lihi Segal has over 20 years of experience leading business and financial operations, spanning Interoperability and Health Information Exchange (HIE), Population Management, Electronic Health Records and Analytics. Before launching DayTwo, Lihi was COO and CFO of Sisense, a leading provider of business intelligence and analytics software, and CFO of dbMotion Ltd. where she was instrumental in growing the company up until its acquisition by Allscripts Healthcare, a leading U.S. EMR company. Prior to that, Lihi held senior roles in a number of businesses, from startups to large public enterprises. She is also a lawyer with an LLB from Tel-Aviv University and an MBA from Northwestern University. Additional resources: DayTwo website Watch a demo of the DayTwo app My book: "On the Brink: A Fresh Lens to Take Your Business to New Heights" Our website: Simon Associates Management Consultants    Download the 1-page synopsis of my book, "On the Brink: A Fresh Lens to Take Your Business to New Heights" here

Lihi Segal is the CEO and co-founder of revolutionary microbiome-based health app, DayTwo, which uses big data and machine learning algorithms to create personalised nutrition plans. DayTwo is based on research conducted by Professor Eran Segal and Eran Elinav from the Weizmann Institute in Israel, which was used to create an algorithm that can predict a patient’s glucose response to foods based on their personal and microbiome data. The algorithm was shown to accurately predict blood glucose responses in 800 participants whose individual blood glucose was highly variable in response to the same meal. Since 2016, DayTwo has offered their accessible and personalised healthcare services throughout Israel and the United States, delivering evidence-based and personalised healthcare to consumers.

Lihi Segal is the CEO and co-founder of revolutionary microbiome-based health app, DayTwo, which uses big data and machine learning algorithms to create personalised nutrition plans. DayTwo is based on research conducted by Professor Eran Segal and Eran Elinav from the Weizmann Institute in Israel, which was used to create an algorithm that can predict a patient’s glucose response to foods based on their personal and microbiome data. The algorithm was shown to accurately predict blood glucose responses in 800 participants whose individual blood glucose was highly variable in response to the same meal. Since 2016, DayTwo has offered their accessible and personalised healthcare services throughout Israel and the United States, delivering evidence-based and personalised healthcare to consumers.

Last November, Cell published a popular study explaining how the glycemic response to foods can differ greatly by individual. This landmark paper on personalized nutrition has since yielded follow-up research and a perspective on how our gut microbes play a role in our individual responses to diet. Catarina Sacristan discusses the findings with Eran Elinav and Eran Segal of the Weizmann Institute of Science.Related Papers: Cell Host & Microbe, Zmora, Zeevi, and Korem et al.: Taking it Personally: Personalized Utilization of the Human Microbiome in Health and Disease; Cell, Levy and Thaiss et al.: Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling; Cell, Zeevi and Korem et al.: Personalized Nutrition by Prediction of Glycemic Responses