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Podcast Notes


    • May 3, 2022 LATEST EPISODE
    • weekdays NEW EPISODES
    • 1h 17m AVG DURATION
    • 607 EPISODES


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    Latest episodes from Podcast Notes Playlist: Latest Episodes

    Episode #165 ... Ralph Waldo Emerson - Nature and Other Things

    Play Episode Listen Later May 3, 2022 27:56

    Philosophize This! Podcast Notes Key Takeaways Check out Philosophize This! Episode Page & Show NotesRead the full notes @ podcastnotes.orgToday we continue our discussion of Emerson. 

    #276 – Michael Saylor: Bitcoin, Inflation, and the Future of Money

    Play Episode Listen Later Apr 29, 2022 242:29

    Artificial Intelligence Podcast Michael Saylor is the CEO of MicroStrategy and a prominent holder and proponent of Bitcoin. Please support this podcast by checking out our sponsors: – Scale: https://scale.com/lex – Coinbase: https://coinbase.com/lex to get $10 in free Bitcoin – Audible: https://audible.com/lex to get $9.95 a month for 6 months – NetSuite: http://netsuite.com/lex to get free product tour – SimpliSafe: https://simplisafe.com/lex and use code LEX EPISODE LINKS: Michael's Twitter: https://twitter.com/saylor MicroStrategy: https://microstrategy.com/ Michael's Book: https://amzn.to/37J2iA0 Book mentioned: https://amzn.to/3jwsIaP PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: – Check out

    The Logic of Rage

    Play Episode Listen Later Apr 28, 2022 49:22

    Hidden Brain ✓ Claim Neuroscientist Doug Fields was on a trip to Europe when a pickpocket stole his wallet. Doug, normally mild-mannered, became enraged — and his fury turned him into a stranger to himself. This week, we revisit a favorite 2020 episode about the secret logic of irrational anger.If you like this show, please check out our new podcast, My Unsung Hero! And if you'd like to support our work, you can do so at support.hiddenbrain.org.

    The Science & Health Benefits of Deliberate Heat Exposure | Episode 69

    Play Episode Listen Later Apr 28, 2022 113:10

    Huberman Lab Podcast Notes Key Takeaways Regular use of sauna and other heat exposure can reduce mortality by cardiovascular events, stroke, and all-cause mortalityEffects of deliberate heat mimic cardiovascular exerciseGeneral guideline to start heat stimulus: temperature must be between 176F-212F for 5-20 minutes, 2-7 times per week – later in the day is better to activate cooling mechanisms and assist with sleepFind what works for you: choose either higher heat intensity and shorter bouts, or lower heat intensity and longer bouts – but always between 176F-212FMake sure you're replacing the water you lose in the sauna – drink at least 16 ounces of water for every 10 minutes of sauna useIf growth hormone increase is your main goal for sauna use, limit to 1x/week or 1x/10 days – and enter fasted or without food in the 2-3 hours prior for maximum benefitsProper application of local heat may actually change the identity of fat cells at that location and encourage the conversion of white fat to beige fatRead the full notes @ podcastnotes.orgI describe the mechanisms by which deliberate heat exposure impacts body temperature, metabolism, heart health, hormone production, exercise recovery, cognition, mood, and longevity. I detail specific protocols for deliberate heat exposure, including exposure times, temperature ranges to consider, time of day, and delivery mechanisms (sauna vs. hot bath vs. open air heat, etc.) in order to achieve different specific outcomes, including dramatic growth hormone releases, or reduction in cortisol levels. I also discuss the ability of locally applied heat to heal or otherwise improve various bodily tissues and new data on how local application of heat may induce the conversion of metabolically sluggish white fat to metabolically robust beige fat. Thank you to our sponsors LMNT: https://drinklmnt.com/huberman InsideTracker: https://insidetracker.com/huberman ROKA - https://www.roka.com - code "huberman" See Andrew Huberman Live: The Brain Body Contract Tuesday, May 17th: Seattle, WA Wednesday, May 18th: Portland, OR https://hubermanlab.com/tour Our Patreon page https://www.patreon.com/andrewhuberman Supplements from Momentous I am pleased to announce that the Huberman Lab Podcast is now partnered with Momentous. Momentous supplements are of the very highest quality; each is third-party tested for purity and accuracy of dosage. To learn more about the Huberman Lab Podcast-Momentous partnership, the supplements I that take, and stay up-to-date with future product announcements, visit: https://www.livemomentous.com/huberman. For the full show notes, visit hubermanlab.com. Timestamps (00:00:00) Heat & Health (00:03:37) Momentous Supplements (00:04:52) The Brain-Body Contract (00:05:46) LMNT, InsideTracker, ROKA (00:09:31) Body Shell Temperature vs. Body Core Temperature (00:13:28) Thermal Regulation, Hyperthermia (00:17:36) Heat Removal Circuits, Pre-Optic Hypothalamus (POA) (00:26:30) Protocols & Benefits of Deliberate Heat Exposure (00:33:37) Tools & Conditions for Deliberate Heat Exposure (00:38:47) Deliberate Heat Exposure, Cortisol & Cardiovascular Health (00:44:50) Heat Shock Proteins (HSPs), Molecular Mechanisms of Heat Regulation (00:47:56) Longevity & Heat Exposure, FOXO3 (00:52:30) Deliberate Cold & Heat Exposure & Metabolism (00:54:48) Deliberate Heat Exposure & Growth Hormone (01:04:32) Parameters for Heat & Cold Exposure (01:08:26) Circadian Rhythm & Body Temperature, Cold & Heat Exposure (01:12:00) Heat Exposure & Growth Hormone (01:16:20) Tool: Hydration & Sauna (01:17:10) Heat, Endorphins & Dynorphins, Mood (01:28:44) Tool: Glabrous Skin To Heat or Cool (01:35:33) Local Hyperthermia, Converting White Fat to Beige Fat, Metabolism (01:47:00) Hormesis/Mitohormesis & Heat/Cold Exposure (01:49:11) Benefits of Heat Exposure (01:51:10) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous Supplements, Instagram, Twitter, Neural Network Newsletter Title Card Photo Credit: Mike Blabac Disclaimer

    Building Towards American Dynamism with Chris Power, CEO of Hadrian

    Play Episode Listen Later Apr 28, 2022 54:50

    a16z Live Podcast Notes Key Takeaways Check out a16z Podcast Episode Page & Show NotesRead the full notes @ podcastnotes.orgKatherine Boyle, General Partner at a16z is joined by Hadrian founder and CEO Chris Power, Packy McCormick, founder of Not Boring, and a16z co-founder Marc Andreessen to discuss the opportunity to automate and upskill in the precision parts industry and shore up U.S. manufacturing with new technology.

    #80: You have more influence than you think

    Play Episode Listen Later Apr 26, 2022 26:15

    Nudge - Marketing Science Simplified✓Claim Podcast Notes Key Takeaways “When we think of influence, we think of influences. But, we rarely think about ourselves. We don't tend to think about the influence we naturally have, which is why you probably have more influence than you think.”– Phill AgnewInfluence is so much more than social media engagement, it's about understanding the psychology of your interactionsAllowing yourself to look past your biases will reveal the natural influence you have in your everyday lifeVanessa and Phill explore the everyday biases that hold us back from seeing our natural influence:The Invisibility Cloak Illusion: Tendency to (incorrectly) believe that you notice people more than they notice youThe Spotlight Effect: Tendency to overestimate how much others notice aspects of one's appearance or behaviorAnd more!“Basing your happiness on comparisons isn't helpful because we are hopeless at setting reliable benchmarks for those comparisons”– Phill AgnewIt can't be logically true for the average person to think they are less social than the average personEngage more and worry less about getting things perfectThe positive outcomes almost always outweigh the negativeDon't be limited by perception—it's usually incorrect anywayRead the full notes @ podcastnotes.orgWhen you think of influence you probably think of Beyonce, Ronaldo, or Obama. But you don't think about yourself. In today's show, Professor Vanessa Bohns talks about the influence you already have. She explains why we underestimate how many people like our company, why we overestimate how social our friends are, and how we change our views depending on who we're talking to. Tune in and I guarantee you'll learn something surprising about yourself. Vanessa's book: https://www.vanessabohns.com/ Follow Vanessa on Twitter: https://twitter.com/profbohns Sign up for the Nudge Newsletter: https://www.nudgepodcast.com/mailing-list

    10-K Diver — Finance For Everyone (EP.101)

    Play Episode Listen Later Apr 26, 2022 70:37

    Infinite Loops Podcast Notes Key Takeaways “We are deterministic thinkers living in a probabilistic world, hilarity or tragedy often ensue”– Jim O'ShaughnessyMany of 10-K Diver'sTwitter threads point out the faults in deterministic thinking by analyzing mathematics and using first principles thinking to study financial conceptsWe often ask the wrong questions – this thread is a great exampleStudying history can save you from FOMO investingIn the 1900s, there were 200 car manufacturers. Obviously, only a few survived. Knowing this context can help you slow down your decision-making before rushing into the next hyped tech stock.Always work through the numbers before ever opening your mouthIf you think you know something, write it out. You'll more often than not realize that you're not prepared to speak about it yet.Intuitions can lead you astray from the truth and even your actual opinion on something10-K Diver thinks Warren Buffett's and Charlie Munger's buy-and-hold philosophies get overgeneralized, leading to misconceptions about their actual investment strategiesRead the full notes @ podcastnotes.orgAs Chamath Palihapitiya put it back in April 2021, 10-K Diver is “one of the best fintwit accounts on Twitter.” 10-K Diver loves breaking down complex financial topics and helping people understand them via engaging Twitter threads. You can follow 10-K Diver on Twitter at https://twitter.com/10kdiver and read all his threads at https://10kdiver.com/twitter-threads/ Show Notes: Curating aggressively Is there a long term plan? Reasoning from the first principles Volatility tax Do markets have a memory? Financial Independence, Retire Early (FIRE) Mental models for investing Premeditating Jim's GIF game Is it a Lindy or a turkey? The ‘Money Concepts' show Benefits and pitfalls of leverage What's next for the 10-K diver? Books Mentioned: Reminiscences of a Stock Operator; by Edwin Lefèvre Happy; by Derren Brown

    #462 - Nick Maggiulli - The Best Way To Build Your Personal Wealth

    Play Episode Listen Later Apr 23, 2022 83:36

    Modern Wisdom Nick Maggiulli is the Chief Operating Officer for Ritholtz Wealth Management and an expert in personal finance using data analysis. Saving money and building wealth are some of the most popular content on the internet. But what are the absolute best ways to maximise your fortune? Nick has broken down the complex world of personal finance to find out what the data says about different strategies. Expect to learn why earning more is better than spending less, why buying the dip is a losing strategy, the easiest way to invest in the stock market, how to spend money guilt-free, why almost everyone has a backward retirement strategy, how to tell when you should sell, what the Vanderbilt's lost fortune can teach us about spending money and much more... Sponsors: Join the Modern Wisdom Community to connect with me & other listeners - https://modernwisdom.locals.com/ Get 30% discount on your at-home testosterone test at https://trylgc.com/modern (use code: MODERN30) Get perfect teeth 70% cheaper than other invisible aligners from DW Aligners at http://dwaligners.co.uk/modernwisdom (use code MODERN10) Get 5 Free Travel Packs, Free Liquid Vitamin D and Free Shipping from Athletic Greens at https://athleticgreens.com/modernwisdom (discount automatically applied) Extra Stuff: Buy Just Keep Buying - https://amzn.to/3OcdXID Check out Nick's blog - http://ofdollarsanddata.com/  Get my free Reading List of 100 books to read before you die → https://chriswillx.com/books/ To support me on Patreon (thank you): https://www.patreon.com/modernwisdom - Get in touch. Instagram: https://www.instagram.com/chriswillx Twitter: https://www.twitter.com/chriswillx YouTube: https://www.youtube.com/modernwisdompodcast Email: https://chriswillx.com/contact/ 

    #122 Robert Cialdini - The Principles of Persuasion

    Play Episode Listen Later Apr 22, 2022 64:47

    Knowledge Project What are the best strategies to get people to say “Yes” to your requests in life? Acclaimed psychologist Robert Cialdini dives deep into the seven small things that make a huge impact in influencing others, as well as the difference between being influenced and being manipulated into making decisions. What are the tactics, how do they work, and how do we defend against them? This episode is jam-packed with practical advice that will make you more persuasive in life.   Known colloquially as “The Godfather of Influence,” Cialdini is a foundational expert in the science of influence and how to apply it ethically in business. His books, including Influence: Psychology of Persuasion and Pre-Suasion, have sold more than 7 million copies in 44 different languages, and he is the Regents' Professor Emeritus of Psychology and Marketing at Arizona State University.    -- Go Premium and get the full episode. Members get early access, ad-free episodes, hand-edited transcripts, searchable transcripts, member-only episodes, and more. Sign up at: https://fs.blog/membership/   Every Sunday our newsletter shares timeless insights and ideas that you can use at work and home. Add it to your inbox: https://fs.blog/newsletter/   Follow Shane on Twitter at: https://twitter.com/ShaneAParrish

    Using Light (Sunlight, Blue Light & Red Light) to Optimize Health | Episode 68

    Play Episode Listen Later Apr 21, 2022 143:42

    Huberman Lab Podcast Notes Key Takeaways Light can change the genes that the cells of the body express directly and indirectlyThere are more than 100 years of science supporting the use of specific types of light to support the health of the brain and bodyDifferent wavelengths of light impact our tissues at different levels – shortwave light (e.g., blue, UV) doesn't penetrate beyond the top surface of the skin; longwave light (e.g., red) penetrates deep through the skin to boneThink of light as a communicator of what's going on in the environment around you and either taken at the surface or deeper and passed off as instructions to other areas or organs of the bodyTip: if you wake up in the middle of the night, try not the flip on a light (or use longwave light) so you don't disrupt melatonin levelsSunlight and day length can impact the melatonin pathway and directly trigger hormone pathways (testosterone and estrogen), desire to mate, and mating behaviorUsing light to optimize testosterone and estrogen: get about 20 minutes of light exposure to as much skin as possible, 2-3 times per week minimumExperiencing pain? Go outside & get direct UVB light on the skin and in the eyes! On longer days or in bright light environments, we tolerate pain (nociception) betterBenefits of direct UVB exposure on eyes & skin: enhanced immune function, increased turnover (growth) of stem cells in hair and nails, sleep regulation, faster wound healing, increases in hormonesTip for shift workers or people awake at night for childcare, etc.: if you need to be awake at night, red light is the best choice because it will not inhibit melatonin or increase cortisolObvious but worth stating: when we talk about light exposure to the eyes, it shouldn't be painful to look at or force you to squint or turn away – it's too bright to safely look at if that's the caseRead the full notes @ podcastnotes.orgI describe the mechanisms by which different wavelengths of light impact the cells, tissues and organs of the human body, and how specifically timed light exposure of specific wavelengths can be used to improve sleep, enhance alertness, modulate hormone levels, and improve mood. I also explain the use of ultraviolet and infrared phototherapies to relieve pain increase testosterone and estrogen levels; improve skin health, appearance and wound healing; and how red light can be used to offset age-related vision loss and provide neuroprotection. Throughout the episode, I describe the mechanisms of light-based therapies and actionable tools that people can use positively impact mental and physical health. Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman Thesis: https://takethesis.com/huberman LMNT: https://drinklmnt.com/huberman See Andrew Huberman Live: The Brain Body Contract Tuesday, May 17th: Seattle, WA Wednesday, May 18th: Portland, OR https://hubermanlab.com/tour Our Patreon page https://www.patreon.com/andrewhuberman Supplements from Thorne https://www.thorne.com/u/huberman For the full show notes, visit hubermanlab.com. Timestamps (00:00:00) Using Light to Improve Health (00:04:31) The Brain-Body Contract (00:05:17) AG1 (Athletic Greens), Thesis, LMNT (00:09:56) Physics of Light, Electromagnetic Energy (00:12:23) Wavelengths of Light (00:15:38) How Light Penetrates Tissues (00:20:13) Light & the Body: Direct & Indirect Signals (00:28:35) Light, Seasonality & Melatonin (00:33:40) Melatonin: Regulatory & Protective Effects (00:38:49) Tools: Optimizing Melatonin Levels (00:44:49) Sun (UVB light) Exposure, Mating Behavior, Testosterone & Estrogen (00:58:09) Seasonality, Romantic Passion & Testosterone (01:02:13) Tool: Skin Sun Exposure & Testosterone (01:06:13) Light & Improved Pain Tolerance (01:11:55) Protocol: Sun Exposure & Chronic Pain (01:12:48) Tools: Sunlight (UVB), Blue-Light Blockers, Seasonal Affective Disorder (SAD) (01:19:44) Light & Enhanced Immune Function (01:23:30) Tool: Light During Winter Months (01:26:18) Light Therapies: Local vs. Systemic Exposure (01:28:54) Tool: Improving Mood, Timing of Natural & Artificial Light (01:32:44) Light Conditions & Sleep Optimization (01:39:00) Infrared Light, Skin & Wound Healing (01:46:00) Infrared Light Therapy & Skin, Low-Level Laser (Light) Therapy (LLLT) (01:49:20) Infrared Light & Age-Related Vision Loss (01:59:36) Tools: Infrared Panels, Morning Exposure (02:05:22) Infrared Light at Night, Shift Work (02:08:35) Light Flicker Phototherapy & Neuroprotection (02:19:07) Phototherapies for Health (02:20:50) Zero-Cost Support, YouTube Feedback, Spotify Reviews, Apple Reviews, Sponsors, Patreon, Thorne, Instagram, Twitter, Neural Network Newsletter, Brain-Body Contract Title Card Photo Credit: Mike Blabac Disclaimer

    #277 – Andrew Huberman: Focus, Stress, Relationships, and Friendship

    Play Episode Listen Later Apr 20, 2022 211:39

    Artificial Intelligence Podcast Podcast Notes Key Takeaways Before recording his podcast, Huberman takes a walk to estimate his energy levelsWhile walking, he recites/sings the lyrics of a song he likes out loud The process calms him down, makes him more focused, and warms up his vocal cords“The reach of the podcast [ Huberman Lab ] is really fascinating, it's not the numbers of the listeners, it's the depth of connection you have with certain people.” – Lex FridmanIt's not just about freedom of speech to say controversial things it's also freedom of speech to be weird, e.g. Ellon Musk posting sex memesHuberman likes the idea of authenticity without oversharingPeople lose careers based on the movement of their thumbs (inappropriate online behavior)“As an educator in the classroom but also on social media my absolute favorite thing is when the comments about other people's comments are positively reinforcing so you see people having conversations within the comments.”– Andrew HubermanNon-Sleep Deep Rest (NSDR) – a term coined by Huberman – involves different techniques that bring the brain and body into a state of relaxationDistinctly different from meditationTerrific at allowing people to learn to shift their state of consciousness, reset energy levels and focusReveri (self-hypnosis app) Huberman uses it to achieve a state of deep relaxation if he can't sleepSearch Youtube for NSDR scriptsCheck out Madefor, Michael Seeley for long hypnosis scripts (free)The more you do them the more quickly you can shift your brain into a state of deep relaxation“The best thing that anyone can do for their mental health physical health and performance in athletic or cognitive endeavors or creative endeavors is to make sure that you're getting enough quality sleep.” – Andrew HubermanBinaural beats of 40 hertz can shift the brain into a heightened state of focus and cognitionRitalin, Adderall – don't use them without a prescription (hits the dopamine system way too hard)Where you place your screen is important; place it at eye level or above youThe only really hard part of a good relationship is dealing with oneself and taking good care of the other person Read the full notes @ podcastnotes.orgAndrew Huberman is a neuroscientist at Stanford and host of the Huberman Lab Podcast. Please support this podcast by checking out our sponsors: – Brave: https://brave.com/lex – LMNT: https://drinkLMNT.com/lex to get free sample pack – ROKA: https://roka.com/ and use code LEX to get 20% off your first order – Indeed: https://indeed.com/lex to get $75 credit – MasterClass: https://masterclass.com/lex to get 15% off EPISODE LINKS: Andrew's YouTube: https://youtube.com/AndrewHubermanLab Huberman Lab Podcast: https://hubermanlab.com Andrew's Twitter: https://twitter.com/hubermanlab Andrew's Instagram: https://instagram.com/hubermanlab PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: –

    How to Optimize Your Hormones for Health & Vitality | Episode 67

    Play Episode Listen Later Apr 15, 2022 179:21

    Huberman Lab Podcast Notes Key Takeaways Six pillars of hormone health: (1) diet (specifically caloric restriction); (2) exercise (specifically resistance training); (3) stress & stress optimization; (4) sleep optimization; (5) sunlight; (6) spirit – dial in the body, mind, and soul connectionThink of yourself as a Venn diagram: you have a body, mind, and soul – you can't completely be well if you're missing the health of one areaTip to get your doctor to order more bloodwork than the basic panel: tell your doctor your (fill in the blank) – energy, sleep, endurance, etc. – is not as good as it used to beHigh alcohol intake and smoking marijuana will ultimately decrease testosteroneCaffeine has a negligible effect on hormonesVegans: you are possibly at risk of not getting enough of certain types of fats and nutrients to maintain a proper ratio of testosterone to estrogen – supplement with algae or other healthy fatsTo naturally increase growth hormone output: don't eat within 2 hours of sleep, get good deep sleep, resistance exercise early in the day, manage stress        A word of caution about peptides: work with a physician! There are so many bad quality peptides with detrimental side effects       Read the full notes @ podcastnotes.orgMy guest is Dr. Kyle Gillett, MD, a dual board-certified physician in family medicine and obesity medicine and an expert in optimizing hormone levels to improve overall health and well-being in both men and women. We discuss how to improve hormones using behavioral, nutritional, and exercise-based tools and safely and rationally approach supplementation and hormone therapies. We discuss testosterone and estrogen and how those hormones relate to fertility, mood, aging, relationships, disease pathologies, thyroid hormone, growth hormone, prolactin, dopamine and peptides that impact physical and mental health and vitality across the lifespan. The episode is rich with scientific mechanisms and tools for people to consider. Thank you to our sponsors Thesis: https://takethesis.com/huberman InsideTracker: https://insidetracker.com/huberman ROKA: https://roka.com - use code "huberman" See Andrew Huberman Live: The Brain Body Contract Tuesday, May 17th: Seattle, WA Wednesday, May 18th: Portland, OR https://hubermanlab.com/tour Our Patreon page https://www.patreon.com/andrewhuberman Supplements from Thorne https://www.thorne.com/u/huberman For the full show notes, visit hubermanlab.com. Timestamps (00:00:00) Dr. Kyle Gillett, MD, Hormone Optimization    (00:03:10) The Brain-Body Contract  (00:04:10) Thesis, InsideTracker, ROKA (00:08:24) Preventative Medicine & Hormone Health  (00:14:17) The Six Pillars of Hormone Health Optimization (00:17:14) Diet for Hormone Health, Blood Testing (00:20:21) Exercise for Hormone Health  (00:21:06) Caloric Restriction, Obesity & Testosterone  (00:23:55) Intermittent Fasting, Growth Hormone (GH), IGF-1 (00:29:08) Sleep Quality & Hormones (00:35:03) Testosterone in Women (00:38:55) Dihydrotestosterone (DHT), Hair Loss  (00:43:46) DHT in Men and Women, Turmeric/Curcumin, Creatine (00:50:10) 5-Alpha Reductase, Finasteride, Saw Palmetto  (00:52:30) Hair loss, DHT, Creatine Monohydrate (00:55:07) Hair Regrowth, Male Pattern Baldness (00:58:12) Polycystic Ovary Syndrome (PCOS), Inositol, DIM (01:04:00) Oral Contraception, Perceived Attractiveness, Fertility  (01:10:31) Testosterone & Marijuana or Alcohol (01:14:27) Sleep Supplement Frequency (01:15:34) Testosterone Supplementation & Prostate Cancer  (01:20:24) Prostate Health, Dietary Fiber, Saw Palmetto, C-Reactive Protein   (01:24:05) Prostate Health & Pelvic Floor, Viagra, Tadalafil  (01:30:54) Testosterone Replacement Therapy (TRT) (01:35:17) Estrogen & Aromatase Inhibitors, Calcium D-Glucarate, DIM  (01:39:28) Lifestyle Factors to Increase Testosterone/Estrogen Levels, Dietary Fats  (01:45:34) Aromatase Supplements: Ecdysterone, Turkesterone (01:47:04) Tongkat Ali (Long Jack), Estrogen/Testosterone levels  (01:52:25) Fadogia Agrestis, Luteinizing Hormone (LH), Frequency (01:56:44) Boron, Sex Hormone Binding Globulin (SHBG) (01:58:13) Human Chorionic Gonadotropin (hCG), Fertility (02:04:18) Prolactin & Dopamine, Pituitary Damage  (02:08:34) Augmenting Dopamine Levels: Casein, Gluten, Vitamin E, Vitamin B6 (P5P) (02:12:30) L-Carnitine & Fertility, TMAO & Allicin (Garlic)  (02:18:19) Blood Test Frequency  (02:19:41) Long-Term Relationships & Effects on Hormones (02:25:33) Nesting Instincts: Prolactin, Childbirth & Relationships (02:29:05) Cold & Hot Exposure, Hormones & Fertility (02:32:34) Peptide Hormones: Insulin, Tesamorelin, Ghrelin  (02:37:24) Growth Hormone-Releasing Peptides (GHRPs) (02:39:38) BPC-157 & Injury, Dosing Frequency (02:45:23) Uses for Melanotan  (02:48:21) Spiritual Health Impact on Mental & Physical Health  (02:54:18) Caffeine & Hormones  (02:56:19) Neural Network Newsletter, Zero-Cost Support, YouTube Feedback, Spotify Review, Apple Reviews, Sponsors, Patreon, Thorne, Instagram, Twitter, Brain-Body Contract Title Card Photo Credit: Mike Blabac Disclaimer

    594: BiggerPockets Podcast 594: Seeing Greene: FHA Loans, Cash Flow Shrinkage, & Bidding $200k Over Asking

    Play Episode Listen Later Apr 15, 2022 54:59

    BiggerPockets Real Estate Podcast Inflation and cash flow have been fighting against each other for decades. As soon as you increase the rent on an income property, inflation comes right in to eat some of that gain. So in today's borderline hyperinflationary environment, is cash flow still coming out on top? A better question to ask may be, what happens in five, ten, or twenty years? Will inflation completely erode your financial freedom dreams? Or will cash flow match (or beat) this destructive force.This isn't just a question that impacts real estate investors—it affects almost every individual working within today's economy. In today's episode of Seeing Greene, David goes deep into this question (and others) so you, the investors, can have a better understanding of our economy as a whole. You'll also hear topics like whether or not you can transfer title on an FHA loan, what to do when bidding wars push prices well above market comparables, when to cosign and when to ask for a cosigner, and what every investor in their twenties should start doing today.Heard a topic that you wanted more explanation on? Want to ask David a question you've never heard before? If so, submit your question here so David can answer it on the next episode of Seeing Greene. Hop on the BiggerPockets forums and ask other investors their take, or follow David on Instagram to see when he's going live so you can hop on a live Q&A and get your question answered on the spot!In This Episode We Cover:How spending power changes the way investors calculate cash flowTransferring title from your personal name into an LLC with an FHA loanHow to know a house is “worth it” and what to look for in a loan officerCosigning for a relative to house hack and staying up-to-code with owner-occupied loansPivoting markets from a cash flow market to an appreciation marketDavid's advice to every young, aspiring real estate investorAnd So Much More!Links from the ShowBiggerPockets Youtube ChannelBiggerPockets ForumsBiggerPockets Pro MembershipBiggerPockets BookstoreSubmit Your Questions to David GreeneBiggerPockets Podcast 567: Seeing Greene: Finding Cash Flow, Refinancing Sooner, & NNN PropertiesBiggerPockets Podcast 570: Seeing Greene: Signs of a Great Agent, When to Refi, and How to ScaleBiggerPockets Podcast 571: Is This Deal Worth My Time? The 6 Crucial Steps to Vet a Multifamily SeaBiggerPockets Podcast 577: Cutting Your Tax Bill, Investing in Different Markets, & “Investor Pressure” | Coaching CallsBiggerPockets Podcast 582: Seeing Greene: Investing in Paradise, Timing the Market, and House HackingBiggerPockets Podcast 585: Seeing Greene: Boosting Your Appraisal, Backward BRRRRs, & Capital Raising RisksBiggerPockets Podcast 588: Seeing Greene: Climate Change, ADU Dilemmas, & Retiring with RentalsBiggerPockets Podcast 591: Seeing Greene: The Cash Flow Market “Mirage” That Traps New InvestorsDavid Greene MeetupsDavid Greene TeamClick here to check the full show notes: https://www.biggerpockets.com/blog/real-estate-594See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

    #218: Sahil Bloom – Become A Magnet For Success

    Play Episode Listen Later Apr 15, 2022 64:10

    The Danny Miranda Podcast Podcast Notes Key Takeaways Check out The Danny Miranda Podcast Episode Page & Show NotesRead the full notes @ podcastnotes.org(0:00) Sahil compliments me (0:45) Crazy coincidence (2:40) Sahil's been plugging his Twitter since 2011 (3:44) Why Sahil is attracted to motivational tracks (6:31) Obesity research at Nike (11:40) The transition from arrogance to kindness (15:25) Identity (Indian + Jewish parents, nerd + jock) (18:27) 10-year reunion (20:14) Practices that made Sahil more secure? (21:39) Darkest hour friend (25:15) What to say in dark times to a friend? (27:15) How to accept compliments (28:08) “I appreciate you” (30:05) Why Sahil microanalyses life (32:00) Condoleezza Rice (36:29) Cold email (37:38) Going to the gym with Tim Cook (39:20) Why is Sahil so connected to highly successful people (46:30) What can someone do today to show grit and work ethic? (50:02) Zone of genius (59:15) How to single focus (1:00:55) More walks without tech (1:03:10) Connecting with Sahil Sahil Bloom is an investor, entrepreneur, and creator. In less than 2 years, Sahil has gained over 500,000 Twitter followers. But in this episode, we didn't focus that much on his hyper-growth online. Instead, we spoke about how Sahil got mentored by BOTH Tim Cook and Condoleezza Rice, how Sahil became more secure in himself, and what it means to be a "darkest hour friend." Sahil's Twitter – https://twitter.com/SahilBloom Continue the conversation with me...

    Vitalik: Ethereum, Part 1

    Play Episode Listen Later Apr 14, 2022 46:07

    Naval's Podcast and Periscope Sessions Introduction 0:00 Haseeb's background 0:22 Vitalik's background 2:43 A blockchain you can build any app on top of 7:02 Eth trades efficiency for transparency 10:18 Like plain text, Eth is simple and efficient 12:41 Only high-value transactions can afford the blockchain 13:08 Doing away with ‘trusted' third parties 14:09 Trading performance for security 14:43 ‘Impregnable castles made of math' 16:23 Ethereum's limitations are latency and privacy 16:56 There are ways to get back your privacy 19:32 Can Eth provide a high level of decentralization and a high level of scaling at the same time? 20:39 Sharding leads to more centralization 21:49 Verifiability at the expense of scaling 24:00 How much decentralization is the right amount? 25:11 What happens when subsidies to join nodes disappear? 27:07 Stateless clients make it possible to verify the chain with very little on your hard drive 28:18 Staking culture is difficult to cultivate 28:52 New blockchain players tend to go for minimum viable decentralization 29:54 People don't value privacy until somebody goes to jail over it 30:32 Eth is ‘simple at the base' 31:12 Social recovery wallets make it easier to be your own bank 31:44 Block space is getting expensive 32:41 There's not a lot of innovation on Bitcoin, by design 33:35 Blockchain's ‘free-rider effect' 34:57 Innovation is slowest at Layer 1 35:34 Layer 2 moves faster because it's permissionless 36:59 What if we froze Layer 1 today? 37:25 Data for computation trade-off 38:57 Benchmarking blockchains apples-to-apples 40:02 Enshrining decentralization 41:43 Tensions between scaling and preserving value 42:27 There will be multiple stores of value 43:54 — Transcript http://nav.al/vitalik

    #275 – Rick Rubin: Legendary Music Producer

    Play Episode Listen Later Apr 12, 2022 207:48

    Artificial Intelligence Podcast Podcast Notes Key Takeaways “It seems like music has the ability to bring us so much depth in our soul that's hard to access any other way”– Rick RubinThe beauty of music is its open interpretationThe artist and the listener do not have to share the same meaning or experienceThere are no rules to music, every idea deserves its own opportunity for trial and errorNew ideas often sound bad until they are attemptedThe ideas that breakthrough rarely breakthrough in the predicted way. So give your ideas a chance! You never know how it will turn out.Production and performance are two very different things“The best version is when someone is feeling something internally and we're capturing it. The other version is they are performing for someone.” – Rick RubinThe best recordings happen in an intimate and isolated setting where the stakes are lowDon't listen to anyone, make the things that you love, whatever they may be. Make it for an audience of one—you.“You can't make art with someone else in mind, I don't believe it can be good” – Rick RubinContinue reading for countless quotes that music lovers from all genres can relate to. Rick Rubin is truly a legend of the industry.Read the full notes @ podcastnotes.orgRick Rubin is one of the greatest music producers of all time, working with many of the greats including Beastie Boys, Eminem, Metallica, LL Cool J, Kanye West, Slayer, Tom Petty, Johnny Cash, Dixie Chicks, Aerosmith, Adele, Danzig, Red Hot Chili Peppers, System of a Down, Jay-Z, Black Sabbath. Please support this podcast by checking out our sponsors: – Lambda: https://lambdalabs.com/lex – Theragun: https://therabody.com/lex to get 30 day trial – ROKA: https://roka.com/ and use code LEX to get 20% off your first order – Onnit: https://lexfridman.com/onnit to get up to 10% off – ExpressVPN: https://expressvpn.com/lexpod and use code LexPod to

    Using Deliberate Cold Exposure for Heath and Performance | Episode 66

    Play Episode Listen Later Apr 12, 2022 135:08

    Huberman Lab Podcast Notes Key Takeaways Check out the Huberman Lab Episode Page & Show NotesRead the full notes @ podcastnotes.orgI describe mechanisms by which deliberate cold exposure can enhance mental health, physical health, and performance. I detail specific protocols to safely engage in deliberate cold exposure, including minimal exposure times, time-of-day effects, determining optimal temperatures, recovery, mindset, and movement during cold exposure. I discuss how cold exposure can be used to safely stress the body to improve attention, mood, and cognitive focus and boost metabolism and reduce inflammation. Also, I explain how cold exposure on specific regions of the body (called glabrous skin surfaces) can be leveraged to enhance endurance and weight training and increase work output. Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman ROKA: https://roka.com - use code "huberman" Helix Sleep: https://helixsleep.com/huberman See Andrew Huberman Live: The Brain Body Contract Tuesday, May 17th: Seattle, WA Wednesday, May 18th: Portland, OR https://hubermanlab.com/tour Our Patreon page https://www.patreon.com/andrewhuberman Supplements from Thorne https://www.thorne.com/u/huberman For the full show notes, visit hubermanlab.com. Timestamps (00:00:00) Deliberate Cold Exposure, Health Warning (00:04:23) Tool: Moderate Exercise & Cognitive Work (00:10:47) The Brain-Body Contract (00:11:32) AG1 (Athletic Greens), ROKA, Helix Sleep (00:15:37) Circadian Rhythm & Body Temperature (00:18:41) Tool: Quickly Decrease Core Body Temperature, Glabrous Skin (00:25:26) Mental Effects of Cold Exposure (00:29:02) Physical Effects of Cold Exposure (00:30:11) How Cold Should the Temperature Be? (00:34:53) Cold Showers vs. Cold Water Immersion (00:38:27) Protocols for Cold Exposure (00:50:57) Optimal Mindset(s) During Cold Exposure (00:55:26) Tool: Using Movement During Cold Exposure (00:57:51) Optimal Frequency of Cold Exposure (01:00:22) Cold Exposure for Dopamine, Mood & Focus (01:12:55) Cold Exposure & Metabolism, Brown Fat (01:25:55) Tool: Caffeine, Dopamine & Cold Exposure (01:29:14) Tools: Increasing Metabolism w/Cold – The Søberg Principle, Shivering (01:34:15) Norepinephrine & Fat Cells (01:36:22) Cold, Physical Performance, Inflammation (01:47:36) Hyperthermia & Glabrous Skin Cooling (01:53:27) Tool: Palmar Cooling & Endurance (02:03:18) Cold Exposure to Groin, Increasing Testosterone (02:07:50) Tool: Optimal Timing for Daily Cold Exposure (02:11:16) Neural Network Newsletter, Zero-Cost Support, YouTube Feedback, Spotify Reviews, Apple Reviews, Sponsors, Patreon, Thorne, Instagram, Twitter Title Card Photo Credit: Mike Blabac Disclaimer: The Huberman Lab Podcast is for general informational purposes only and does not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast or materials linked from this podcast is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professionals for any such conditions.

    385- Perfectionism and ADHD: Making ‘Good Enough' Work for You

    Play Episode Listen Later Apr 12, 2022 61:19

    ADHD Experts Podcast ✓ Claim Podcast Notes Key Takeaways Check out ADHD Experts Podcast Episode Page & Show NotesRead the full notes @ podcastnotes.org Behaviors like setting unrealistic goals and insisting on personal flawlessness point to a cycle of perfectionism. Join Sharon Saline, Psy.D., to learn more about the relationship between anxiety, perfectionism, and ADHD and how to nurture a growth mindset.

    Set Your Kids Up for a Lifetime of Healthy Sleep

    Play Episode Listen Later Apr 7, 2022 53:21

    Art of Manliness When neurologist and sleep specialist Dr. Chris Winter sees adult patients in his sleep clinic, they often come to him because of a struggle with insomnia, which, as he described in a previous appearance on the AoM podcast, is caused by stressing too much about sleep, so that going to bed becomes an anxious and fear-inducing routine that sabotages the natural needs and rhythms of the sleep cycle.Chris would see fewer adult patients like this if, when they were kids, their parents set them up to have a healthy relationship with sleep.How to establish that kind of healthy relationship is something Chris writes about in his latest book, The Rested Child, and is the topic of our conversation today. Chris will take us through what parents should know about their kids' sleep from the womb through young adulthood, with tips on both how to improve your children's sleep, and how to avoid messing it up, including his take on co-sleeping, why he let his kids go to bed whenever they wanted, and why he discourages giving children melatonin to help them sleep.Resources Related to the PodcastChris' last appearance on the show — episode #661: Get Better Sleep By Stressing About It LessNational Sleep Foundation's graph and write-up of sleep duration recommendations across the lifespanConnect With Dr. Chris WinterChris on InstagramChris on Twitter

    #273 – Chris Blattman: War and Violence

    Play Episode Listen Later Apr 7, 2022 174:20

    Artificial Intelligence Podcast Podcast Notes Key Takeaways Long prolonged war is hardly ever positive-sum; the costs almost always outweigh the implied justice“Fighting is just politics by other means–inefficient, devastating, and costly means.” – Chris Blattman“War is the violence that doesn't make sense” – Chris BlattmanWar is a breakdown of reason – everybody loses something from war and there's usually a better and more efficient solutionWar is rare and history shows we're pretty successful at avoiding it–but that's not how history is taughtWe overemphasize the anecdotal and don't look at the objective data–usually to fuel the warmonger narrative, which is driven by one of the five root causes of war (below)Both Russia and Ukraine have incentives to bluff, which can result in many short-term conflicts but also affect long-term compromise/appeasement“If you bluff and lose, it's not because you miscalculated. You made an optimal choice given the uncertainty of the situation to take a gamble–that's a wiser thing for you to do than to not bluff.” – Chris BlattmanThis call and bluff dynamic could end up with Russia getting what they originally were asking for from Ukraine–but only after incurring unnecessary costs“There's a reason for every war and a war for every reason” – The five roots of war:Unchecked leaders: leaders do not bear the majority of costs or have a private incentive (Chris believes this is the fundamental cause of most violence in the world)Uncertainty: when the opposing group's strength or intentions are ambiguous, war seems like an appropriate risk to combat uncertaintyCommitment problems: some circumstances give one side an irresistible incentive to risk warIntangible incentives: intransigence for ideologies, choosing war rather than changing your viewMisperceptions: miscalculating the complexity of the enemy or yourselvesRead the full notes @ podcastnotes.orgChris Blattman is a professor at the University of Chicago studying the causes and consequences of violence and war. Please support this podcast by checking out our sponsors: – Truebill: https://truebill.com/lex – Mizzen+Main: https://mizzenandmain.com and use code LEX to get $35 off – Grammarly: https://grammarly.com/lex to get 20% off premium – Indeed: https://indeed.com/lex to get $75 credit – Eight Sleep: https://www.eightsleep.com/lex and use code LEX to get special savings EPISODE LINKS: Chris's Twitter: https://twitter.com/cblatts Chris's Website: https://chrisblattman.com Why We Fight (book): https://amzn.to/3702fjb PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips:

    Kierkegaard on the Present (Passionless) Age

    Play Episode Listen Later Apr 7, 2022 59:59

    Art of Manliness Podcast Notes Key Takeaways Check out The Art of Manliness Episode Page & Show NotesRead the full notes @ podcastnotes.orgDo you ever feel like the time we live in feels flat, complacent, timid, conformist, populated by people who are focused on playing it safe and are inwardly empty?A century and a half ago, the Danish philosopher Soren Kierkegaard felt the same way about the period in which he lived, and posited that there are two kinds of ages: the revolutionary, decisive, and passionate, and the sensible, rational, and reflective.Here to unpack Kierkegaard's ideas on these two kinds of ages is Jacob Howland, retired professor of philosophy and author of Kierkegaard and Socrates. Today on the show, Jacob and I first discuss some background on Kierkegaard and his existential philosophy. We then get into the differences between an age of passion and an age of reflection. We discuss how in a passionate age, an individual stands as an individual, possesses an energy which focuses on truth and ideals, and has the courage to take bold leaps of faith, while in a reflective age, the individual is subsumed by the crowd, is afraid of public opinion, and gets so lost in analysis and abstraction that he never makes a decisive move. All along the way, we delve into how Kierkegaard's description of his age parallels our own, and Kierkegaard's evergreen call to be an individual, embrace risk, and own your opinions and actions.Resources Related to the PodcastWorks by Kierkegaard mentioned in the show:Two Ages: A Literary ReviewEither/OrFear and TremblingThe Sickness Unto DeathPhilosophical FragmentsConcluding Unscientific Postscript on Philosophical FragmentsThomasine Christine Gyllembourg-EhrensvärdGeorg Wilhelm Friedrich HegelOn the Advantage and Disadvantage of History for Life by Friedrich Nietzsche “Yes, Sabermetrics Ruined Baseball”AoM Article: Your Three Selves and How Not to Fall Into DespairAoM Article: An Intro to EnvyAoM Podcast #635: The Existentialist's Survival GuideConnect With Jacob HowlandJacob's Website

    92. Is Poor Nutrition a Supply Problem or a Demand Problem?

    Play Episode Listen Later Apr 5, 2022 33:38

    No Stupid Questions Podcast Notes Key Takeaways Poor nutrition is a 90% demand problem and only a 10% supply problemCiting data fromFood Deserts and the Causes of Nutritional InequalityJust being more accessible didn't change purchase behavior for food, it requires high levels of education to counter deeply embedded cultural and demographic nutrition habitsHealthy food has an uphill narrative battle against unhealthy foodMore expensive, less ready to prepare, low-shelf life, less caloric, and the list goes on“If there is a way to increase demand for healthy food, without making people feel bad, that's going to be the trick”– Angela DuckworthIt worked with smoking cigarettes, why can't it work with food?Implementing taxes on unhealthy food and subsidizing healthy food could help ignite a much needed social and cultural changeWhat other societal topics miscalculate supply and demand problems?Bipartisan politicians: everyone complains there are none, but no one wants their politicians to compromiseSleep: people always say they don't get enough sleep, but it's not for lack of time–they choose to do other thingsRead the full notes @ podcastnotes.org

    #201 - Deep dive back into Zone 2 | Iñigo San-Millán, Ph.D. (Pt. 2)

    Play Episode Listen Later Apr 2, 2022 165:31

    Drive with Dr. Peter Attia Podcast Notes Key Takeaways Fat oxidation, carbohydrates, and lactate are connected – lactate is the byproduct of glucose utilizationThe capacity to transport lactate through high-intensity exercise is trainableWell-trained & elite athletes have an amazing ability to oxidize lactate in mitochondria – but everyone gets to a point where the effort can't be sustained, the difference is how long it takes you to get therePeople with metabolic syndrome who are characterized by having poor mitochondrial function cannot do an exercise oxidized with lactate because they produce lactate but can't oxidize the lactate (their slow-twitch muscles don't have mitochondria to use fat so rely on glucose)A reasonable measure of how zone 2 should feel: you can carry out a full conversation, maybe not as comfortably as if you weren't exercising, but still without much strain – the other person will know you're exercising but you are understandableZone 2 is necessary for mitochondrial health, high intensity is necessary for glycolytic efficiency (which you can improve in just a matter of months if consistent)Ideal training protocol: 4 days of zone 2 training lasting 60-90 minutes + 1 day of anaerobic/high-intensity effortHigh-intensity suggestion: keep it simple – 4 minutes high effort, near heart rate max + 4 minutes of recovery x 4-5 cyclesPSA: to be considered a zone 2 workout, you need to spend the entire duration in zone 2 for the benefit – not just an average of zone 2 oscillating faster and slower periodsRead the full notes @ podcastnotes.org View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Episode Description: Iñigo San-Millán is an internationally renowned applied physiologist and a previous guest on The Drive. His research and clinical work focuses on exercise-related metabolism, metabolic health, diabetes, cancer metabolism, nutrition, sports performance, and critical care. In this episode, Iñigo describes how his work with Tour de France winner Tadej Pogačar has provided insights into the amazing potential of elite athletes from a performance and metabolic perspective. He speaks specifically about lactate levels, fat oxidation, how carbohydrates in food can affect our lactate and how equal lactate outputs between an athlete and a metabolically unhealthy individual can mean different things. Next, he discusses how Zone 2 training boosts mitochondrial function and impacts longevity. He explains the different metrics for assessing one's Zone 2 threshold and describes the optimal dose, frequency, duration, and type of exercise for Zone 2. Additionally, he offers his thoughts on how to incorporate high intensity training (Zone 5) to optimize health, as well as the potential of metformin and NAD to boost mitochondrial health. Finally, he discusses insights he's gathered from studying the mitochondria of long COVID patients in the ICU. We discuss: The amazing potential of cyclist Tadej Pogačar [3:00]; Metrics for assessing athletic performance in cyclists and how that impacts race strategy [8:30]; The impact of performance-enhancing drugs and the potential for transparency into athletes' data during competition [17:00]; Tadej Pogačar's race strategy and mindset at the Tour de France [24:00]; Defining Zone 2, fat oxidation, and how they are measured [26:45]; Using fat and carbohydrate utilization to calculate mitochondrial function and metabolic flexibility [35:45]; Lactate levels and fat oxidation as it relates to Zone 2 exercise [40:00]; How moderately active individuals should train to improve metabolic function and maximize mitochondrial performance [51:45]; Bioenergetics of the cell and what is different in elite athletes [57:30]; How the level of carbohydrate in the diet affects fuel utilization and power output during exercise [1:08:30]; Glutamine as a source for making glycogen—insights from studying the altered metabolism of ICU patients [1:15:00]; How exercise mobilizes glucose transporters—an important factor in diabetic patients [1:21:00]; Metrics for finding Zone 2 threshold—lactate, heart rate, and more [1:25:00]; Optimal Zone 2 training: dose, frequency, duration, and type of exercise [1:41:15]; How to incorporate high intensity training (Zone 5) to increase VO2 max and optimize fitness [1:51:15]; Compounding benefits of Zone 2 exercise and how we can improve metabolic health into old age [2:01:45]; The effects of metformin, NAD, and supplements on mitochondrial function [2:05:15]; The role of lactate and exercise in cancer [2:13:30]; How assessing metabolic parameters in long COVID patients provides insights into this disease [2:19:00]; The advantages of using cellular surrogates of metabolism instead of VO2 max for prescribing exercise [2:25:45]; Metabolomics reveals how cellular metabolism is altered in sedentary individuals [2:33:45]; Cellular changes in the metabolism of people with diabetes and metabolic syndrome [2:39:15]; and More. Sign Up to Receive Peter's Weekly Newsletter Connect With Peter on Twitter, Instagram, Facebook and YouTube

    #133 Andrew Huberman: The Science of Small Changes

    Play Episode Listen Later Apr 2, 2022 105:05

    Knowledge Project Podcast Notes Key Takeaways Check out The Knowledge Project Episode Page & Show NotesRead the full notes @ podcastnotes.org Leading neuroscientist and Stanford University School of Medicine professor Dr. Andrew Huberman goes in-depth on how small behaviors can make a huge impact on your health.  Dr. Huberman offers essential insights into how light affects your sleep and your energy levels, which supplements actually work, tips to control bad impulses, exercises to slow the aging process, and so much more.   Dr. Huberman has made numerous significant contributions to the fields of brain development, brain function and neural plasticity, which is the ability of our nervous system to rewire and learn new behaviors, skills and cognitive functioning. Huberman is a McKnight Foundation and Pew Foundation Fellow and was awarded the Cogan Award in 2017, given to the scientist making the most significant discoveries in the study of vision. His lab's most recent work focuses on the influence of vision and respiration on human performance and brain states, such as fear and courage.   -- Want even more? Members get early access, hand-edited transcripts, member-only episodes, and so much more. Learn more here: https://fs.blog/membership/ Every Sunday our Brain Food newsletter shares timeless insights and ideas that you can use at work and home. Add it to your inbox: https://fs.blog/newsletter/ Follow Shane on Twitter at: https://twitter.com/ShaneAParrish

    Become a Backyard Adventurer

    Play Episode Listen Later Mar 31, 2022 42:18

    Art of Manliness A lot of people feel like they've seen and done everything there is to see and do in their local area. They're bored of their daily routine, and contemplate going off on some grand adventure in a exotic locale.My guest would say that you don't actually have to wait until your next big trip nor go far afield to mix things up, and that adventure can be found right where you are, in your ordinary routines, the everyday landscape of your life, and even DIY projects, if you decide to approach them in a different way.His name is Beau Miles and he's an Australian filmmaker who documents his own small-scale adventures on YouTube, as well as the author of The Backyard Adventurer. Today on the show, Beau shares his experiments in proving anything can be infused with the challenge, intrigue, and fun which mark adventure, if you add in some intentional risk, difficulty, and simple what-the-heck quirkiness. He tells us about some of the close-to-home adventures he's executed, including walking and kayaking his 90-kilometer commute to work, reconnecting an old, long closed-down rail line by running its often hidden, overgrown path with a shovel in his hand, and making a paddle with scavenged wood. We then talk about how he created a gastronomical adventure for himself by eating his body weight in beans, and even turned tackling his to-do list into an adventure by pairing the crossing off of its entries with running a marathon in 24 hours. Along the way, Beau shares how backyard adventures help you better get to know your local area, how he deals with the police who sometimes check in on what he's up to, and how the next time you get some odd idea, you ought to just go for it, mate.Resources Related to the PodcastBeau's films/adventures mentioned in the show:Walking to WorkPaddling to WorkJunk PaddleHuman BeanRun the LineMile an HourAoM Article: My 8-Week Microadventure ChallengeAoM Podcast #120: Microadventures With Alastair HumphreysAoM Podcast #560: The Magic of WalkingTortilla Flat by John SteinbeckConnect With Beau MilesBeau's WebsiteBeau on YouTubeBeau on Instagram

    Dr. Andy Galpin: How to Build Strength, Muscle Size & Endurance | Episode 65

    Play Episode Listen Later Mar 31, 2022 211:27

    Huberman Lab Podcast Notes Key Takeaways Training frequency is important for every adaptation you are seekingIn general: strive to work all joints through all ranges of motions throughout the weekThe different methods of exercise aren't about what's good or bad or right or wrong, but what adaptation do you want?Hypertrophy training & anaerobic training give you the most physiological adaptations across the most categoriesThe driver of strength is intensity but the driver of hypertrophy is volumeSoreness is not a barometer of an effective or good workout! You want to feel the muscle group worked but should hover around a soreness of 3 out of 10Intentionality in exercise matters: are you doing enough to check the box or are you focusing on contracting your muscle groups?You're better off cutting your workout short and hitting a focused 30 minutes than going through the motions for 60 minutesBreathing properly during & after exercise is critical for telling your body you're safe: (1) maintain a breath-hold during the lowering/eccentric most dangerous part of the movement & exhale on the concentric portion; (2) try physiologic sigh for 2-5 minutes post-workout and/or between strenuous bouts (double inhale through the nose followed by long exhale through mouth)The interference effect has recently been debated but overblown – zone 2 cardio in and of itself will not blunt strength or hypertrophy – what matters more is your calorie supply and the type of cardio you're doing; running (constant eccentric pounding) will have a greater consequence than bike riding  The interference effect is not something most of us need to worry about when comparing the benefit of well-roundedness for overall physiologic healthSample weekly schedule for endurance: do something once a week that gets you to max heart rate (roughly 220-age) x 4-8 bouts; 150-180 minutes zone 2 training; strength & hypertrophy training supplementTraining protocols should be based on your points of failure – where are you weak and need work?Speed, power, strength training tips: pick 3-5 exercises, 3-5 reps, 3-5 sets, take 3-5 minutes rest between, train 3-5 days per week – (85% 1RM for strength; 40-70% 1RM for power)Hypertrophy target: a minimum of 10 working sets, per muscle group, per week, 5-30 reps per setEndurance training isn't just about how long you can work, it's about maintaining joint integrity and allowing muscles to not fatigue when you need them to engage heavy or fast (even standing up)“You did not get hurt deadlifting because deadlifts are dangerous. You only get hurt deadlifting because you either got in a bad position – you got in a bad position because you either started in a bad position or you ended up in a bad position. You did too much volume, too much intensity, or too much complexity.” – Dr. Andy GalpinFoundation for proper fluid intake per day = bodyweight/2 (in ounces)Galpin equation for fluid replenishment during exercise or demanding activity: start exercise hydrated with electrolytes (not just water) then every 15 minutes consume (in ounces) your body weight (in pounds) / 30Be judicious in determining whether you're pushing yourself for adaptation (i.e., pushing stress and not worried about recovery) – or optimization which is the opposite and requires balanceRead the full notes @ podcastnotes.orgMy guest is Dr. Andy Galpin, Professor of Kinesiology at California State University, Fullerton, and one of the foremost experts in the world on the science and application of methods to increase strength, hypertrophy and endurance performance. We discuss fundamental principles of strength and hypertrophy training and building endurance, the mechanisms underlying them and we review specific protocols to optimize training and recovery. We also discuss hydration, sleep, nutrition, supplements, and mental tools that can be leveraged to accelerate adaptations leading to enhanced strength, muscle growth and/or endurance. Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman Thesis: https://takethesis.com/huberman InsideTracker: https://insidetracker.com/huberman See Andrew Huberman Live: The Brain Body Contract Tuesday, May 17th: Seattle, WA Wednesday, May 18th: Portland, OR https://hubermanlab.com/tour Our Patreon page https://www.patreon.com/andrewhuberman Supplements from Thorne https://www.thorne.com/u/huberman Huberman Lab Social & Website Instagram Twitter Facebook TikTok Website Newsletter Dr. Andy Galpin Links Twitter Instagram Website Published Work Absolute Rest For the full show notes, visit hubermanlab.com. Timestamps (00:00:00) Dr. Andy Galpin, Strength & Endurance Training   (00:03:08) The Brain-Body Contract  (00:03:55) AG1 (Athletic Greens), Thesis, InsideTracker (00:08:20) Adaptations of Exercise, Progressive Overload  (00:14:40) Modifiable Variables, One-Rep Max, Muscle Soreness (00:27:30) Modifiable Variables of Strength Training, Supersets   (00:43:50) How to Select Training Frequency: Strength vs. Hypertrophy  (00:58:45) Hypertrophy Training, Repetition Ranges, Blood Flow Restriction  (01:08:50) Tools: Protocols for Strength Training, the 3 by 5 Concept  (01:10:48) Mind-Muscle Connection  (01:16:16) Mental Awareness  (01:27:57) Breathing Tools for Resistance Training & Post-Training  (01:37:25) Endurance Training & Combining with Strength (01:51:20) Tools: Protocols for Endurance Training (02:08:15) Muscular Endurance, Fast vs. Slow Twitch Muscle  (02:16:35) Hydration & the Galpin Equation, Sodium, Fasting    (02:35:57) Cold Exposure & Training   (02:43:15) Heat Exposure & Training  (02:53:47) Recovery   (03:04:02) Tool: Sodium Bicarbonate (03:17:26) Tool: Creatine Monohydrate (03:20:08) Absolute Rest (03:29:08) Zero-Cost Support, YouTube Feedback, Spotify, Apple Reviews, Sponsors, Patreon, Thorne, Instagram, Twitter Title Card Photo Credit: Mike Blabac Disclaimer

    #71: Heike Schoen - Invitation - How To Rescue Your Clinical Trial When at Risk to Fail

    Play Episode Listen Later Mar 28, 2022 96:44

    Beginner's Mind ✓ Claim Podcast Notes Key Takeaways Check out Beginner's Mind Episode Page & Show NotesRead the full notes @ podcastnotes.orgDid you know that almost 90% of all product ideas fail in clinical trials? The most obvious reason that a clinical trial fails is lack of efficacy. Surprising to me was that lack of efficacy doesn't seem to be the main reason why clinical trials fail in the first place. Other factors are at play, and most of them are manageable risks when the right team is at work.In this episode, we talk about:Strategic considerations for setting up a clinical trialInhouse vs Outsourced Clinical Study ManagementWhy do some clinical trials fail?Steps to getting your clinical trial back on trackFuture trends of clinical trialsand much moreWho is the expert in the show?Heike Schön is the Managing Director and Co-Founder of Lumis International GmbH and Lumis Life Science Consulting GmbH.She has more than 25 years of experience in leadership positions in international clinical research and drug development.

    20VC: David Friedberg on The Framework for Business Value Creation, The Bifurcation in Venture Today That No One Talks About, The Impact of Interest Rate Hikes on Venture and Step by Step; How TPB Incubates, Funds and Exits The Next Generation of Companie

    Play Episode Listen Later Mar 28, 2022 44:34

    Twenty Minute VC Podcast Notes Key Takeaways Check out the 20VC Episode Page & Podcast NotesRead the full notes @ podcastnotes.org David Friedberg is Founder and CEO of The Production Board (TPB), a holding company established to solve the most fundamental problems that affect our planet, by reimagining global systems of production. Prior to founding The Production Board, David founded The Climate Corporation, a 10-year journey that culminated in their $930M acquisition by Monsanto. If that was not enough, David is the Founder and Chairman at Metromile and also sits on the board of Soylent, Clara Foods, Tillable, Cana Technologies and more. In Today's Episode with David Friedberg You Will Learn: 1.) Origins: How David made his way into the world of startups and technology from academia and physics? What were David's biggest takeaways from scaling The Climate Corp to $930M exit to Monsanto? How did the exit put pressure on David for all future companies he builds? How does he manage that? 2.) The Macro: Venture + The Economy How does David foresee the impending rate hikes? What impact will this have on venture and the economy? What segment of the market will be first to be hit? Why is growth investing last to be hit? How does early stage play out in this very new environment? How will we see the velocity of capital deployment change in this new period? What does David believe are some of the crucial flaws of the venture model? How does David reflect on his own price sensitivity? What lessons has he learned from deals he has done or missed that have changed his perspective? 3.) David Frankel: The Business Builder What is David's rubrik for business value creation? How has this changed with time? How mentally plastic does one have to be around the time it takes to see margins, unit economics etc change from negative to positive? How does David and the team approach building new companies at TPB? Where do they find the founding teams? How do they incentivise them? How does TPB approach continuous funding for the companies they create? What milestones need to be hit? How do they assess them? How does David approach liquidity with regards to exits for the companies they create? Why does their holding company structure mean they have different incentives to VCs? 4.) David Friedberg: Father and Husband How does David reflect on his own relationship to money today? How has it changed over time? What have been David's biggest realisations on what provides him true happiness? How did having children change his operating mentality? What does being a great father mean to David? Item's Mentioned In Today's Episode with David Friedberg David's Favourite Book: Zen Mind, Beginner's Mind

    Controlling Sugar Cravings & Metabolism with Science-Based Tools | Episode 64

    Play Episode Listen Later Mar 23, 2022 118:55

    Huberman Lab Podcast Notes Key Takeaways Any time you eat something sweet, that food substance causes neuropod cells in the gut to send parallel signals to the brain which activates dopamine and tells us to seek out and eat more sweet foodsGlucose is the preferred source of fuel for the brain and nervous system (in a typical diet regimen): mechanisms hardwired into us that make it difficult not to eat the sweet food or give in to the cravingGetting sweet things into the body has a bit to do with the taste but just as much to do with the nutritive component for the nervous system those sweet things carryFruits have been improperly demonized; the fructose content of fruit is quite low – it's the high fructose corn syrups and sugary beverages we really want to avoidIt's no accident that “hidden sugars” are hidden with salt or other flavors – it's done so people will ingest more of a particular food regardless of how sweet that food tastesThe case for eliminating or reducing sugary drinks: if glucose is replaced with fructose in sugary drinks, there's a decrease in type 2 diabetes and metabolic syndrome associated with high fructose corn syrup, even if the same number of calories is ingestedSleep! Quality sleep is critical to form a firm foundation of proper metabolism and to help combat sugar cravingsHome remedies to offset glucose spikes: (1) a few tablespoons of lemon juice or lime juice – or (2) a little pure cinnamon – before, during, or after a large meal or sugar intake can blunt glucose responseRead the full notes @ podcastnotes.orgI explain how to blunt sugar cravings through fundamental knowledge of how sugar is sensed, metabolized, and utilized within the body. I explain how sugar is processed through the digestive tract and nervous system and how both the taste and nutritive components of sugar can lead to specific appetite changes and cravings. I discuss the connection between sugar, dopamine, and cravings and outline many tools to curb sugar cravings, specifically craving highly processed refined sugars. Thank you to our sponsors Thesis: https://takethesis.com/huberman AG1 (Athletic Greens): https://athleticgreens.com/huberman InsideTracker: https://insidetracker.com/huberman See Andrew Huberman Live: The Brain Body Contract Tuesday, May 17th: Seattle, WA Wednesday, May 18th: Portland, OR https://hubermanlab.com/tour Our Patreon page https://www.patreon.com/andrewhuberman Supplements from Thorne https://www.thorne.com/u/huberman For the full show notes, visit hubermanlab.com. Timestamps (00:00:00) Sugar & Physiology (00:02:25) The Brain-Body Contract (00:03:13) Thesis, AG1 (Athletic Greens), InsideTracker (00:07:40) Sugar & the Brain (00:10:06) Appetite & Hormones: Ghrelin & Insulin (00:14:17) Glucose & Brain Function (00:24:19) Glucose & Physical Activity (00:26:16) Fructose vs. Glucose (00:32:41) When to Eat High-Sugar Foods? (00:35:01) Sugar's Taste vs. Nutritive Pathways, Sugar Cravings (00:41:46) Tool: Sugar & the Dopamine, Pleasure – Pain Dichotomy (00:48:43) Subconscious Sugar Circuits, Hidden Sugars in Food (00:58:03) Glucose Metabolism in the Brain (01:03:00) Tool: Glycemic Index, Blunting Sugar Cravings (01:12:08) Sugary Drinks, Highly Refined Sugars (01:14:33) Artificial Sweeteners (01:22:36) ADHD, Omega-3s (01:30:18) Tools: Reduce Sugar Cravings with EPA Omega-3s & Glutamine (01:35:15) Tool: Blunt Sugar Peaks & Craving with Lemon Juice (01:43:09) Tool: Reduce Sugar Cravings & Spikes with Cinnamon (01:45:10) Berberine, Sustained Low Blood Glucose Levels (01:51:24) Tool: Sleep & Sugar Cravings (01:56:33) Zero-Cost Support, YouTube Feedback, Spotify, Apple Reviews, Sponsors, Patreon, Instagram, Twitter, Thorne, Neural Network Newsletter Title Card Photo Credit: Mike Blabac Disclaimer

    #244 Chad Johnson

    Play Episode Listen Later Mar 23, 2022 89:21

    Kyle Kingsbury Podcast Chad Johnson is a permaculture maestro. He's studied under Sepp Holzer and cut his teeth in the North of Minnesota where he practices a permaculture/food forest model of working with the land. He's the man we're working with to help work with the land in Lockhardt. We'll run it back, but here's an incredible intro to him and the work that he does. Connect with Chad:   Website: www.keystoneintelligence.org  Show Notes:   "Desert or Paradise" Sepp Holzer "Sepp Holzer's Permaculture"   The Biggest Little Farm - Amazon Living 4D Ep 97 - Dr. Ibrahim Karim: BioGeometry: Profound Healing Through Ancient Wisdom and Modern Science biogeometry.ca/home   Agriculture - Rudolph Steiner  Regenerative Agriculture - Richard Perkins  Sponsors:   Qualia Mind is hands down the most balanced neurotropic I have in my arsenal right now. Head over to neurohacker.com for a month's supply currently @ 50% off. Punch in code “KKP” for an additional 15% off everything. PaleoValley Some of the best and highest quality goodies I personally get into are available at paleovalley.com, punch in code “KYLE” at checkout and get 15% off everything! Super Speciosa is the absolute best Kratom I've worked with head over to getsuperleaf.com/kkp and punch in “KKP” at checkout for 20% off everything in store! Organifi Go to organifi.com/kkp to get my favorite way to easily get the most potent blend of high vibration fruits, veggies and other goodies into your diet! Click that link and use code “KKP” at checkout for 20% off your order! Connect with Kyle:   Fit For Service Academy App: Fit For Service Academy  Instagram: @livingwiththekingsburys   Youtube: Kyle Kingbury Podcast  Kyles website: www.kingsbu.com  Zion Node: https://getzion.com/ > Enter PubKey  >PubKey: YXykqSCaSTZNMy2pZI2o6RNIN0YDtHgvarhy18dFOU25_asVcBSiu691v4zM6bkLDHtzQB2PJC4AJA7BF19HVWUi7fmQ   Like and subscribe to the podcast anywhere you can find podcasts. Leave a 5-star review and let me know what resonates or doesn't.

    #210: Dr. Sian Proctor – The First Black Woman Pilot In Space

    Play Episode Listen Later Mar 23, 2022 70:34

    The Danny Miranda Podcast Podcast Notes Key Takeaways Check out The Danny Miranda Podcast Episode Page & Show NotesRead the full notes @ podcastnotes.org(0:00) Intro (2:15) Ice hockey experience (5:15) What made Dr. Proctor keep going? (6:00) Meeting Olympian hockey players (9:25) Getting recognized in public (11:53) Almost an astronaut (15:07) Why did Dr. Proctor's friend suggest she apply to be an astronaut? (16:29) How do you cultivate curiosity for new technologies? (18:00) How did Dr. Proctor's dad help her (20:07) Why your self-talk is so important (22:23) Going to Mars? (24:30) What challenges do we face settling on Mars? (26:16) Civilians going to space (28:05) What should we expect on Mars? (30:40) “Learn to be more forgiving to yourself” (33:28) Talking to Michelle Obama (36:58) Starship Earth (40:49) Where does Dr. Proctor feel accepted? (41:52) Seeker poem (44:28) NFTs and saying yes to early technology (50:39) Exploring the inner world (55:49) Jack of all opportunities, master of life experience (56:50) Nickname “Leo” (1:00:40) Meeting Elon Musk (1:04:16) Gryffindor (1:06:37) Is Inspiration4 a family? (1:08:47) Connecting with Dr. Proctor Dr. Sian Proctor is an American geology professor, science communicator, and commercial astronaut. She was launched into Earth orbit, on September 15, 2021, as the pilot of the Crew Dragon space capsule. I originally came across Dr. Proctor when she starred in the Netflix special Countdown: Inspiration4 Mission to Space. In this conversation, we spoke about settling on Mars, getting recognized, and her many talents + interests. Dr. Proctor's Twitter – https://twitter.com/DrSianProctor Space2Inspire – https://www.amazon.com/Space2inspire-Inspiration-Dr-Sian-Proctor/dp/1733765417 Continue the conversation with me...

    Neuroscientist Andrew Huberman On Changing Your Biology With Behavior

    Play Episode Listen Later Mar 22, 2022 141:18

    Rich Roll Podcast Podcast Notes Key Takeaways Where safe, try behavioral tools first: though pharmaceutical intervention will change your chemical balance, it won't help you change your behaviors and train the tools you needThe field of science is shifting toward seriously studying previously “fringe” topics acupuncture, breathwork, effects of temperature regulation, the brain-gut connectionCyclic physiologic sighs seem to have the greatest effect on the greatest number of parameters – to try: two inhales through the nose followed by long exhale through the mouth for 5 minutesClinical hypnosis grabs both states of arousal – a high degree of focus and a high degree of relaxation in a way that enhances neuroplasticityGuided clinical hypnosis has been successful in the treatment of trauma, ADHD, and eating disorders“Much of how we are gauged in terms of who we are is on our behavior and how calm people perceive us to be or how stressed people perceive us to be in certain contexts.” – Dr. Andrew HubermanTo really optimize your output, anchor your biology to our natural 24-hour cycle: get sunlight in your eyes the first hour of waking (or bright overhead light if not accessible) and maintain some exposure in the early part of the day, avoid bright light in the early evening, avoid napping if it interferes with nighttime sleep, maintain a regular sleep/wake scheduleKey is doing self-exploration to find ideal timing of meals, light exposure, and sleep that align with circadian rhythm – start by manipulating light exposure because that's the most powerful driver of the other piecesMajor stimuli for setting brain states: light, temperature, movement, food, social interactionsRead the full notes @ podcastnotes.orgHow does behavior affect your biology? What does neuroscience say about hypnosis, breath work, and meditation? Are behavioral tools more powerful than pharmaceuticals in changing your state and focus?Today we dig into these big questions and more with neuroplasticity overlord Dr. Andrew Huberman, back for a second, highly anticipated return to the show.Given that Dr. Huberman's first appearance on the podcast (RRP #533) has amassed over 10 million views on YouTube alone, chances are you're already familiar with this tenured professor of neurobiology and ophthalmology at Stanford University School of Medicine, where he runs The Huberman Lab, which studies neural regeneration, neuroplasticity, and brain states such as stress, focus, fear, and optimal performance.Subsequent to our first podcast in January of 2021, Andrew launched The Huberman Lab Podcast, which has quickly become a sensation. Within a year of launch, it has ascended to one of the top, most listened to podcasts in the world.Today we pick up where we last left off, diving deep into a wide array of fascinating topics brimming with actionable takeaways, including:the emerging field of mind-body neuroscience;the neuroscience of ADHD, focus, hypnosis, and processing trauma;how to leverage light, temperature, breath, and sleep to better control your biology;several behavioral tools for achieving optimal performance states;how to cultivate learning states and the power of something called gap effects; andmany other fascinating topicsTo read more, click here. You can also watch it all go down on YouTube. And as always, the podcast streams wild and free on Apple Podcasts and Spotify.Andrew is a passionate man with an incredible facility for communicating complex scientific topics in a uniquely compelling and understanding way.For those keen on understanding how to better control your mind, neurochemistry, and all told biology—consider this episode appointment listening.SCIENCE!Peace + Plants, See acast.com/privacy for privacy and opt-out information.

    #131 Matthew Walker: The Power of Sleep

    Play Episode Listen Later Mar 22, 2022 113:02

    Knowledge Project Podcast Notes Key Takeaways Don't force sleep, it's dangerous to stay awake in bed for long periods of time“You'd never sit at the dinner table waiting to get hungry, so why would you lie in bed waiting to get sleepy?” – Matthew WalkerPavlov's Classical Conditioning: your brain will begin to bond a negative association with your bed and being awakeTarget a sleep efficiency of 85%-90% (time spent in bed asleep)The harder you try to sleep, the harder it becomesDon't count sheep, take yourself on a long mental journey. Take your mind off of itself.“The snooze button is the perennial expression of the human frustration of chronic lingering sleep debt”– Matthew WalkerExperiment: If you regularly set an alarm clock, would you wake up at that same relative time without the alarm clock?If no, you're probably operating in a sleep deficitAlcohol and Caffeine before bed reduce your body's ability to benefit from sleepAlcohol is the opposite of a sleep aid, it is a sedative and sedation is not sleepTry to cut off caffeine consumption 10 hours before bedContinue reading for specific biological responsesMatthew mentions some methods for combatting insomnia and sleeping betterCognitive Behavioral Therapy for Insomnia (CBT-I)Sleep Restriction and Behavioral Therapy for InsomniaHow to Determine Your Chronotype and Ideal Sleep ScheduleRead the full notes @ podcastnotes.orgRenowned sleep scientist Matthew Walker discusses everything you need to know about what a better night's sleep can do for your life, and how to prioritize and perfect the way you sleep. Walker breaks down how to identify when you need more sleep, how to deal with insomnia, the best devices to track your sleep, and some unconventional sleep hygiene tips, including why it's never a good idea to count sheep. Walker is a Professor of Neuroscience and Psychology at the University of California-Berkeley, and is also the founder and director of the Center for Human Sleep Science. He has published over 100 scientific research studies on the impact of sleep on human brain function, and he is the author of the 2017 book, Why We Sleep: Unlocking the Power of Sleep and Dreams.   -- Want even more? Members get early access, hand-edited transcripts, member-only episodes, and so much more. Learn more here: https://fs.blog/membership/ Every Sunday our Brain Food newsletter shares timeless insights and ideas that you can use at work and home. Add it to your inbox: https://fs.blog/newsletter/ Follow Shane on Twitter at: https://twitter.com/ShaneAParrish

    Unraveling 32: Enough Already w/Scott Horton

    Play Episode Listen Later Mar 20, 2022 181:58

    Jocko Unravelling ✓ Claim Podcast Notes Key Takeaways Check out The Unraveling Podcast Episode Page & Show NotesDisclaimer: There is no doubt that Putin is the aggressor and is doing terrible things to the Ukrainian people. However, there is a long interwoven history of US misadventures abroad that shouldn't be forgotten.Read the full notes @ podcastnotes.orgJocko and Darryl welcome special guest Scott Horton. Scott is the director of the Libertarian Institute, and the senior editor of antiwar.com. He's also an author of books such as Fool's Errand: Time to End the War in Afghanistan, and Enough Already: Time to End the War on Terror.

    Using Salt to Optimize Mental & Physical Performance | Episode 63

    Play Episode Listen Later Mar 17, 2022 123:53

    Huberman Lab Podcast Notes Key Takeaways Conscious and unconscious salt intake and sensing modulates cravings for sugar, water, and other thingsSodium is the way your neurons communicate – having enough salt in the body allows the brain and nervous system to functionSodium and water work together in the body: thirst is not just a way to bring fluid into our body – it's an internal signal telling us to balance salt level“If you're craving salt, you probably need it.” ­– Dr. Andrew HubermanIt's helpful to have a formula and not just consume salt and water-based on craving because your body tends to adapt to certain levels of salt over time so it doesn't provide a consistent indicatorThe notion that a high salt diet is bad for you is confounded by the fact that high salt diets are usually rich in processed foods and a poor balance of carbohydrates to fatThere's a direct relationship between the stress system (glucocorticoid system) and the salt craving systemIf you're feeling anxious, slightly increasing sodium intake can stabilize blood pressure and ability to lean into stressors and challengesGalpin equation for fluid replenishment during exercise or cognitively demanding activity: start exercise hydrated with electrolytes (not just water) then every 15 minutes consume (in ounces) your body weight (in pounds) / 30Rule of thumb if you fast or follow time-restricted eating: caffeine is a diuretic so for every ounce of caffeine, drink 1.5x as much water with a touch of sodiumVery generalized recommended mineral intake, barring health conditions: 3.2-4.8g of sodium, 4g of potassiumIt's critical that you know your blood pressure to make informed decisions about salt and fluid intake – salt needs will vary accordinglyRead the full notes @ podcastnotes.orgI discuss the role of salt (sodium) in the nervous system and the key role that it plays in mental performance, physical performance and health. I explain how the brain senses salt levels in our body and how that relates to our feelings of thirst. I cover the physiology of the renal system and the hormones that control sodium and water balance in our body. I also explore how salt interacts with stress and our immune systems and its crucial role in neuron function. Additionally, I examine research findings suggesting that some individuals might benefit from increased intake of sodium and other electrolytes (magnesium and potassium) to enhance mental performance, lessen anxiety, and offset dizziness. Yet, other people may need less sodium. I discuss how you can determine your optimal sodium intake and why sodium intake levels need to be uniquely tailored to an individual's lifestyle. Finally, I explain how salt creates ‘hidden' sugars in many processed foods and the problems that can create. Throughout the episode, I explain peer-reviewed findings outlining salt's essential role in overall health and describe general recommendations and tools anyone can use to find their optimal salt balance and thereby enhance their brain and body's performance. Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman LMNT: https://drinklmnt.com/huberman InsideTracker: https://insidetracker.com/huberman Celebrate Pi Day (3.14) with InsideTracker - 31% off through 3.17 with code HUBERMANPIDAY See Andrew Huberman Live: The Brain Body Contract Tuesday, May 17th: Seattle, WA Wednesday, May 18th: Portland, OR https://hubermanlab.com/tour Our Patreon page https://www.patreon.com/andrewhuberman Supplements from Thorne https://www.thorne.com/u/huberman For the full show notes, visit hubermanlab.com. Timestamps (00:00:00) Role of Salt  (00:02:18) The Brain-Body Contract  (00:02:57) Neuropod Cells, Artificial Sweeteners & ‘Hidden' Cravings  (00:10:57) AG1 (Athletic Greens), LMNT, InsideTracker  (00:15:06) Salt Regulation  (00:17:13) How the Brain Senses Salt (00:24:15) Salt & Thirst  (00:29:27) Blood Pressure & Thirst  (00:33:47) Kidneys & Urine Regulation (00:39:08) Vasopressin: Roles in Libido & Urination  (00:45:46) How Much Salt Do You Need?  (00:56:45) Should You Increase Your Salt Intake?  (01:02:19) Tools: Determining Your Individual Salt Intake (01:14:02) Iodine, Sea Salt  (01:17:13) Salt: Roles in Stress & Anxiety  (01:24:20) Other Electrolytes: Magnesium & Potassium  (01:27:57) Tools: Effects of Low-carbohydrate Diets & Caffeine  (01:32:28) General Recommendations for Salt Intake  (01:36:34) Perception of Salt & Sugar Taste, Processed Foods  (01:47:13) Role of Sodium in Neuronal Function, Action Potentials  (01:53:13) Dehydration  (01:55:36) What Salt Intake is Best for You?  (02:00:58) Zero-Cost Support, YouTube Feedback, Spotify, Apple Reviews, Sponsors, Patreon, Thorne, Instagram, Twitter, Neural Network Newsletter  Title Card Photo Credit: Mike Blabac Disclaimer

    Tech's Love Affair With Miami

    Play Episode Listen Later Mar 15, 2022 41:22

    Sway Keith Rabois minted his wealth with Elon Musk, Peter Thiel and other members of the so-called “PayPal Mafia.” Now, though, he's moved to Miami and become one of the city's biggest hype men. He believes Florida — which has already seen an influx of tech bros, venture capital investments and cryptocurrency plays during the pandemic — offers a better home to tech than California can, largely because of the politics. He tells Kara Swisher: “The mayor of Miami, the governor of Florida treat citizens like customers. ‘What can we offer you? How can we help?' That's their goal, and that's how they frame everything.”In this conversation, Kara presses Rabois whether tech's doubling down on Florida is all just about escaping high taxes. They also discuss whether venture capital is what investment banking was in the 2000s. And they catch up on the news, from stock fall-offs in big tech to why Peter Thiel will be stepping down from Meta's board.You can find transcripts (posted midday) and more information for all episodes at nytimes.com/sway, and you can find Kara on Twitter @karaswisher.

    How The Weedkiller Glyphosate Affects Your Body And How To Avoid It

    Play Episode Listen Later Mar 13, 2022 56:24

    Doctor's Farmacy with Mark Hyman, MD Podcast Notes Key Takeaways “[Glyphosate] jams up your biochemistry. It's like throwing sand in an engine.”– Mark Hyman, MDGlyphosate is a weed killer that is exposed to 70% of all cropsGlyphosate can directly impact your microbiome and increase your chances of the leaky gut–which leads to much greater systemic health problemsLeaky gut: the barrier of the gut is broken and the bacteria and food proteins from the gut leak into your bloodstream–creating a systemic and destructive responseThe gut and microbiome is linked to countless chronic conditions: heart disease, auto-immune disorders, allergic disorders, autism, mental health conditions, eczema, and more52% of all children are diagnosed with a chronic condition before they are 16, compared to 1.2% in the 1960s before these chemicals were introduced“We can really start to map out the extinction of mankind” – Dr. Zach BushThe consumer market is having a larger impact on chemical-use regulation than the government ever hasConsumers are refusing to use products with certain chemicalsThis changes the dynamics of regulation–once you divert one company away from chemical use, that company will pressure the government to make industry-wide regulations so they are not at a competitive disadvantageRead the full notes @ podcastnotes.orgThis episode is brought to you by Athletic Greens, Cozy Earth, and Eight Sleep. Glyphosate is a popular pesticide that has a big downside—it's destroying our health. It damages our good gut bacteria and may lead to leaky gut. Glyphosate also depletes glutathione, our master antioxidant and a cornerstone of our biology, and it dramatically impacts our sulfur, methylation, and detoxification pathways that have many essential roles for our health. And not only is glyphosate harming human health and the health of our future generations, it's also destroying our ecosystems.In today's episode, I talk with Dr. Stephanie Seneff, Ken Cook, and Dr. Zach Bush about why it's important to be aware of the effects of glyphosate and make choices that reduce our exposure as much as possible.Stephanie Seneff is a Senior Research Scientist at MIT's Computer Science and Artificial Intelligence Laboratory in Cambridge, Massachusetts. She has a bachelor's degree from MIT in Biology with a minor in Food and Nutrition Science, and a master's degree, an engineer's degree, and a PhD degree, all from MIT, in Electrical Engineering and Computer Science. Her recent interests have focused on the role of toxic chemicals and micronutrient deficiencies in health and disease, with a special emphasis on the pervasive herbicide, glyphosate, and the mineral, sulfur. She is the author of Toxic Legacy: How the Weedkiller Glyphosate Is Destroying Our Health and the Environment. Ken Cook is president and co-founder of the Environmental Working Group, a non-profit, non-partisan organization dedicated to protecting human health and the environment. He is widely recognized as one of the environmental community's most prominent and influential critics of industrial agriculture and the nation's broken approach to protecting families and children from toxic substances. Dr. Zach Bush is a physician specializing in internal medicine, endocrinology, and hospice care. He is an internationally recognized educator and thought leader on the microbiome as it relates to health, disease, and food systems. Dr. Bush founded Seraphic Group and the non-profit Farmer's Footprint to develop root-cause solutions for human and ecological health. His passion for education reaches across many disciplines, including topics such as the role of soil and water ecosystems in human genomics, immunity, and gut-brain health. This episode is brought to you by Athletic Greens, Cozy Earth, and Eight Sleep.Right now, when you purchase AG1 from Athletic Greens, you will receive 10 FREE travel packs with your first purchase by visiting athleticgreens.com/hyman.Get 40% off your Cozy Earth sheets. Just head over to cozyearth.com and use code MARK40.Check out Eight Sleep's Pod Pro mattress or mattress cover and save $150 at checkout at eightsleep.com/mark.Full-length episodes of these interviews can be found here:Dr. Stephanie SeneffKen CookDr. Zach Bush See acast.com/privacy for privacy and opt-out information.

    Episode 33: Suppressing Curiosity: How GPAs, Forced Memorization, and Mandatory Exams May Undermine Open Inquiry, Dylan Selterman

    Play Episode Listen Later Mar 13, 2022 24:53

    Heterodox Out Loud ✓ Claim Podcast Notes Key Takeaways Check out Heterodox Out Loud Episode Page & Show NotesRead the full notes @ podcastnotes.orgOn today's episode of Heterodox Out Loud, we explore the possibility that the ongoing crisis of free inquiry and viewpoint diversity in universities is not a sudden aberration, but instead the inevitable outcome of a rigid, top-down university system. From undermining students' natural curiosity to increasing stress and anxiety, we talk with Dylan Selterman—Social-Personality Psychologist and Associate Teaching Professor at Johns Hopkins University—about the flaws in our current education system and his vision for a more student-led academic future. Dylan's blog post: “Curiosity Is One Key To Heterodoxy. Forced Memorization Is Not.”For more from Dylan, check out his Psychology Today blog called The Resistance Hypothesis. He also hosts a podcast with Manuel Galvan called A Bit More Complicated (available at Apple Spotify Anchor). Let us know what you think! For comments and questions email communications@heterodoxacademy.org.This episode was hosted by Zach Rausch, and produced by Davies Content. Heterodox Out Loud is an ongoing series of selected pieces from heterodox: the blog in audio form with exclusive interviews. 

    Episode 90 - Yaron Naymark: KKR & the PE Landscape

    Play Episode Listen Later Mar 9, 2022 48:00

    The Investing City Podcast In this conversation we cover: - Yaron's investment philosophy - why he is bullish on KKR - an overview of the private equity landscape - and much more! Thank you so much for listening, we really appreciate you. If you have found this valuable, please consider leaving us a review as it will help more people find it! Thanks you're awesome! You can find more information and content by going to these places: Premium Research Website: https://www.investingcity.org YouTube: Investing City Twitter: investing_city Or feel free to email us at service@investingcity.org Again, we really appreciate that you would take the time to listen. Hope it was valuable. Let us know if you have any questions!

    Biotracking, Age Reversal & Other Advanced Health Technologies | Episode 8

    Play Episode Listen Later Mar 9, 2022 69:36

    Lifespan with Dr. David Sinclair ✓ Claim Podcast Notes Key Takeaways Our medical model of “wait until you get sick then go to the doctor” really won't get you where you want to go – the insurance system in the U.S. won't cover testing unless you're sickYou can't impact what you don't measure! Be proactive about measuring and keeping track of what's happening in your body through bloodwork and helpful wearablesTechnology isn't waiting for the laws: it's a matter of when not if – we need data security and privacy protection laws in place, including the right to delete your data, before the use of wearables is rampantWearables and sensors will eventually collect thousands of data points per second and ultimately contribute to “lengthening our lives another decade beyond what we're able to do with changes to lifestyle” – according to Dr. David SinclairThe key is really to take action based on the information you're getting from the wearables and sensors  Supplementation is particularly important for people on a specialized diet – you need to be vigilant about measuring bloodwork to make sure you're doing what's best for your bodyDavid Sinclair's 5 biomarkers worth measuring: (1) glucose; (2) heart function (3) inflammation as measured by, c-reactive protein (CRP), tumor necrosis factor (TNF) alpha, cortisol; (4) lactate; (5) blood oxygen“This is the kind of life I want for everybody, that we don't have to worry about getting cancer in our 50s and 60s and having a heart attack in our 70s. We should be able to live to our 70s, 80s, 90s and beyond in a healthy way, contributing to society, contributing to the community, educating our kids…” – Dr. David SinclairTake responsibility for yourself, and do it for your kids and grandkids' sake: eat the right way, fast, get exercise, give your body a little stress, supplement as needed, monitor your health proactivelyRead the full notes @ podcastnotes.orgIn the final episode of this season, Dr. David Sinclair and Matthew LaPlante focus on current and near-future technologies relevant to health and aging. In addition to discussing the utility of wearable sensors and biological age measurements, they highlight innovative research aimed at reversing biological age. The societal effects of therapies that successfully extend healthspan and/or lifespan are also considered. Thank you to our sponsors: Levels - https://levels.link/sinclair Athletic Greens - https://athleticgreens.com/sinclair InsideTracker - https://insidetracker.com/sinclair Our Patreon page: https://www.patreon.com/davidsinclair Lifespan book: https://amzn.to/3sUqurT Dr. David Sinclair Social: Instagram Twitter Facebook Matthew LaPlante's Social: Twitter To stay up to date with David's work to democratize biological age testing and insights, visit tallyhealth.com. Timestamps: (00:00:00) Introducing Episode Eight: The Future of Anti-aging Medicine (00:03:49) Thanking the Sponsors (00:06:48) Modern Healthcare, Disease Detection, and Circulating DNA (00:11:30) Wearable Monitors: A Dashboard for your Body (00:20:31) Types of Health Sensors (00:24:20) Big Data, Privacy, and Criminal Investigation (00:30:16) Cutting-edge Testing and Biological Age (00:36:40) Using Personalized Data to Inform your Diet (00:41:48) Optimizing Exercise and Activity-mimetics (00:45:02) Resetting the Aging Clock (00:53:45) Repeatable Age Reversal and Safety (00:56:11) Longer Life, Population Size, and Economics (01:00:18) Skillbatical (01:03:06) Putting in the Work for Longevity (01:04:56) Thanking the Podcast Team and Wrapping Up Season One (01:08:27) Options for Subscription and Support For the full show notes, including the peer-reviewed studies, visit the Lifespan podcast website. Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed. Title Card Photo Credit: Mike Blabac Special thanks to our research assistants, Adiv Johnson & Sarah Ryan.

    #266 – Nicole Perlroth: Cybersecurity and the Weapons of Cyberwar

    Play Episode Listen Later Mar 9, 2022 127:42

    Artificial Intelligence Podcast Podcast Notes Key Takeaways “Any geopolitical conflict from now on is guaranteed to have some cyber element to it”– Nicole PerlrothThe colonial pipeline, among other breaches of infrastructure, just recently got disclosed as China-backed intrusions (CISA & FBI report)Uighur ‘watering hole' attack – visiting an informational website about Uighur's automatically dropped an iOS zero-day exploit onto your phone. “The Uighurs are China's test kitchen for surveillance.”– Nicole PerlrothIt has already begun, continue reading for more examples‘Software eats the world‘ is a dangerous and “dumb” narrative for critical infrastructureJust because we can hook all of our systems up to the internet, doesn't mean we shouldThe United States infrastructure is very vulnerable to digital threats – 80% or more of America's critical infrastructure is owned and operated by the private sector with limited cybersecurity standards or legislative oversight“The one rule is like fight club, nobody talks about fight club. Nobody talks about the zero-day market on both sides…When you're operating in the dark like that, it's really easy to put aside your morals.”– Nicole PerlrothThe current hacking environment promotes malicious action and disincentives proactive defense–we need to reestablish motivations among a new cohort of developersRead the full notes @ podcastnotes.orgNicole Perlroth is a cybersecurity journalist and author. Please support this podcast by checking out our sponsors: – Linode: https://linode.com/lex to get $100 free credit – InsideTracker: https://insidetracker.com/lex and use code Lex25 to get 25% off – Onnit: https://lexfridman.com/onnit to get up to 10% off – ROKA: https://roka.com/ and use code LEX to get 20% off your first order – Indeed: https://indeed.com/lex to get $75 credit EPISODE LINKS: Nicole's Twitter: https://twitter.com/nicoleperlroth Nicole's Website: https://nytimes.com/by/nicole-perlroth Nicole's Book: https://amzn.to/3sOQjrs PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: –

    Tim Westergren: How The Band Kept Playing At Pandora

    Play Episode Listen Later Mar 6, 2022 41:52

    Starting Greatness with Mike Maples Podcast Notes Key Takeaways Check out Starting Greatness Episode Page & Show NotesRead the full notes @ podcastnotes.orgTim Westergren maxed out 11 credit cards, racked up hundreds of thousands of dollars in debt, and was rejected 348 times for a second round of funding for his revolutionary idea for a music streaming platform. But like any true artist, Westergren remained committed to his vision of creating an aesthetically more beautiful future with Pandora, and now the company boasts more than 6 million monthly subscribers. Mike Maples, Jr of FLOODGATE interviews Westergren to discuss the company's humble beginnings, why it took an act of Congress to keep the company alive, and why both men believe the best founders are artists who can sell their vision.

    Best Of: What the Heck are NFTs? Let's Ask Beeple.

    Play Episode Listen Later Mar 6, 2022 47:58

    Sway Podcast Notes Key Takeaways NFTs are digital proof of ownership and are still in their nascent stage.The market is definitely a bubble and most art will go to zeroBeeple intends to portray the weirdness of tech and its unintended consequencesRead the full notes @ podcastnotes.orgFrom Snoop Dogg to Melania Trump, it seems like everyone has gotten into the NFT craze in the last year, with billions of dollars worth of sales made in 2021. NFTs may be colloquial now, but the craze really picked up almost a year ago, when an artist named Michael Winkelmann (also known as Beeple) sold his work, “EVERYDAYS: THE FIRST 5000 DAYS,” for a whopping $69 million — the third-highest auction price involving a living artist, after Jeff Koons and David Hockney.So this week, Kara is revisiting her March 2021 conversation with Beeple. They talk about whether his virtual collage, which stitches together 5,000 images (including lactating humanoid breasts and Buzz Lightyear with a bloodied chain saw) is actually worth $69 million, how he grapples with the environmental impact of crypto minting, and how NFTs will change how we buy and flaunt digital ownership.You can find transcripts (posted midday) and more information for all episodes at nytimes.com/sway, and you can find Kara on Twitter @karaswisher.

    The Science of Keeping the Brain Healthy | Episode 7

    Play Episode Listen Later Mar 6, 2022 62:07

    Lifespan with Dr. David Sinclair ✓ Claim Podcast Notes Key Takeaways The paradox of living longer: our brain ages slower than the rest of our body but because modern medicine has helped us live longer, more people are living with cognitive decline, Alzheimer's and dementiaRead the full notes @ podcastnotes.orgIn this episode of the Lifespan podcast, Dr. David Sinclair and co-host Matthew LaPlante dissect the topic of brain aging. They explore evidence suggesting that the brain ages more slowly than other parts of the body and highlight how cognitive function is impacted by aging. Different interventions aimed at preserving brain health are also discussed, including a plant-based diet, exercise, metformin, NAD boosters, and sufficient sleep. Thank you to our sponsors: Athletic Greens - https://athleticgreens.com/sinclair Levels - https://levels.link/sinclair InsideTracker - https://insidetracker.com/sinclair Our Patreon page: https://www.patreon.com/davidsinclair Lifespan book: https://amzn.to/3sUqurT Dr. David Sinclair Social: Instagram Twitter Facebook Matthew LaPlante's Social: Twitter To stay up to date with David's work to democratize biological age testing and insights, visit tallyhealth.com. Timestamps: (00:00:00) Introducing Episode Seven: Aging of the Brain (00:04:39) Thanking the Sponsors (00:07:38) Ex-differentiation as a Driver of Aging (00:09:22) The Brain Ages Slowly (00:14:17) Cognitive Function and Plasticity (00:17:44) Three Longevity Pathways: mTOR, AMPK, and Sirtuins (00:23:26) Plant-based Diets and B-vitamins (00:28:32) Homocysteine, Plaque, and Vasculature (00:32:35) Fatty Acids (00:35:48) Physical Activity (00:39:14) Metformin (00:46:02) NAD Boosters (00:50:33) Increasing Blood Flor (00:53:20) Sleep (00:58:02) Overall Message: Keep your Brain Healthy (00:58:50) Next Week's Episode and the Future of Medicine (01:01:21) Options for Subscription for Support For the full show notes, including the peer-reviewed studies, visit the Lifespan podcast website. Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed. Title Card Photo Credit: Mike Blabac Special thanks to our research assistants, Adiv Johnson & Sarah Ryan.

    Tamar Haspel on First-Hand Food

    Play Episode Listen Later Mar 2, 2022 64:58

    Econtalk What did author and Washington Post columnist Tamar Haspel learn from her quest to eat at least one thing she'd grown, caught, or killed every day? For starters, that just-caught fish always tastes better (unless you've caught a false albacore). That all it takes to build a coop is the will and the right power tools, and that when it comes to homegrown produce, you've got none until you've got way too much. But most of all, she tells EconTalk's Russ Roberts in talking about her book To Boldly Grow, she learned that figuring stuff out to solve problems is more delicious than the most decadent of desserts.

    How to Enhance Your Gut Microbiome for Brain & Overall Health | Episode 61

    Play Episode Listen Later Mar 2, 2022 112:14

    Huberman Lab Podcast Notes Key Takeaways “Our body is shaping the decisions that our brain is making and we're not aware of it, at all.” – Dr. Andrew HubermanWhat you do, eat, think, and feel influences your microbiomeSome microbiota make enzymes locally to digest food, others make neurochemicals that impact brain function and moodOur experience with and desire for certain foods involves how the food tastes, texture, and subconscious processing of taste in our gut which signal certain neuromodulatorsThe gut communicates to the brain to change what we think we want or to change our actual behaviors around foodFood and eating is not just about the food and nutrients we need or don't need, there are subconscious signals and waves of nerve cells always coming from our body and changing the way our brain works“Our brain is very carefully paying attention to whether the levels of dopamine that are being triggered are within a normal range or whether we gorged ourselves.” – Dr. Andrew HubermanCreating the correct environment for microbiota to thrive enhances mood and behaviorParents: the more diversity you can create early, the better chance you're giving your child at healthy brain-gut signaling and immunity  In general, to create a healthy gut microbiome: eat the right foods, consume pro- and pre-biotics sparingly unless going through periods of high stress, travel, or significant change to dietThough fasting has a lot of benefits – we don't know whether it promotes or degrades the microbiome over time but it seems to cause disruption when prolongedNon-diet related ways to enhance microbiome: get deep sleep, maintain proper social interactions, limit prolonged stress and stressorsTo really improve microbiome diversity through diet, consume 4-6 ounces of fermented foods per day – start with 1 and work your way up to avoid gastric distressRead the full notes @ podcastnotes.orgIn this episode, I discuss the profound effect the gut has on the nervous system. I cover the structure and function of the gut-brain axis and the role of the gut microbiome in the brain and overall health. I describe how the gut controls hunger or satiety by affecting neurons in our brain. I also contrast the many pathways by which the gut influences the brain: direct vs. indirect pathways, chemical vs. mechanical, and fast vs. slow signaling. Additionally, I discuss what defines a healthy microbiome and how your lifestyle impacts the gut microbiome, including the effects of stress, fasting, antibiotics, pets, environment, prebiotics and probiotics. I address how different foods shape the gut microbiome, in particular, the emerging data that fermented foods can increase the diversity of healthy gut microbiota. Throughout the episode, I explain peer-reviewed and textbook findings that reveal the critical role of the gut microbiome in supporting mental and physical health and I outline simple tools that anyone can use in order to enhance their gut microbiome health. Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman LMNT: https://drinklmnt.com/huberman InsideTracker: https://insidetracker.com/huberman Our Patreon page https://www.patreon.com/andrewhuberman Supplements from Thorne https://www.thorne.com/u/huberman Social & Website YouTube Instagram Twitter Facebook Website Newsletter Article Links "The Emerging Biology of Gut-Brain Sensory Transduction" "Mechanisms Underlying Microbial-Mediated Changes in Social Behavior in Mouse Models of Autism Spectrum Disorder" "Association of Loneliness and Wisdom With Gut Microbial Diversity and Composition: An Exploratory Study" "Emotional well-being and gut microbiome profiles by enterotype" "Brain fogginess, gas and bloating: a link between SIBO, probiotics and metabolic acidosis" "Gut-microbiota-targeted diets modulate human immune status" "The preference for sugar over sweetener depends on a gut sensor cell" Book Links "The 4-Hour Chef: The Simple Path to Cooking Like a Pro, Learning Anything and Living the Good Life" Timestamps (00:00:00) Gut Microbiome  (00:03:02) AG1 (Athletic Greens), LMNT, InsideTracker  (00:06:55) Your Gut-Brain Axis  (00:09:44) Gut-Brain Anatomy (00:15:32) Microbiota vs. Gut Microbiome  (00:20:01) Roles of Gut Microbiome  (00:23:03) Neuropod Cells: (Subconscious) Tasting with Your Stomach  (00:34:13) Ghrelin: Slow Modulation of Your Brain in Hunger (00:38:02) Glucagon Like Peptide 1; GLP-1  (00:42:22) Tools: ‘Free Will' & Food Cravings  (00:44:46) Mechanical Cues from Gut to Brain (00:49:05) Dopamines, Vomiting  (00:52:06) Indirect Signals from Gut Microbiota (00:59:30) Gut Microbiome “Critical Periods”  (01:03:08) How Gut Health Controls Overall Health  (01:12:25) What is a Healthy Gut Microbiome? (01:15:00) Tools: Enhance Your Gut Microbiome (01:23:49) Foods to Enhance Microbiota Diversity; Fermented Foods  (01:37:07) High-Fiber Diets & Inflammation (01:40:58) Artificial & Non-Caloric Sweeteners  (01:44:27) Structure & Function of Gut-Brain Axis  (01:49:47) Zero-Cost Support, YouTube, Spotify, Apple Reviews, Sponsors, Patreon, Thorne, Instagram, Twitter, Neural Network Newsletter Title Card Photo Credit: Mike Blabac Disclaimer

    #267 – Mark Zuckerberg: Meta, Facebook, Instagram, and the Metaverse

    Play Episode Listen Later Mar 1, 2022 125:51

    Artificial Intelligence Podcast Podcast Notes Key Takeaways The challenging thing with free speech is that there is a line, the thing that everyone disagrees on is the definition of real harm“When there is an acute threat, it does make sense from a societal perspective to tolerate less speech” – Mark ZuckerbergYou can't yell fire in a crowded movie theater–was Covid a fire or not? Mark says yes based on the info he was given.The blame for improper censorship doesn't entirely fall on tech companies, blame should also be directed at the institutions of the United States that fail to define harm accurately and honestlyThe Social Dilemma vs.What ‘The Social Dilemma' Gets WrongWhat grabs someone's attention in the near term is not going to grab it over the long termMaking a user angry isn't going to retain that user, Facebook doesn't have an incentive to do thisSubscription product models have pitfalls too, not just ad-based product modelsGreater polarization has been found in groups that are least likely to use the internet or social media(link)The goal of the metaverse is not to build technology for people to interact with; but rather, build technology for people to interact with each otherSpatial audio and eye contact technology are just two features to drastically improve on current video meeting technology, for exampleEstablishing a presence is the most difficult problemRead the full notes @ podcastnotes.orgMark Zuckerberg is CEO of Meta, formerly Facebook. Please support this podcast by checking out our sponsors: – Paperspace: https://gradient.run/lex to get $15 credit – Coinbase: https://coinbase.com/lex to get $5 in free Bitcoin – InsideTracker: https://insidetracker.com/lex and use code Lex25 to get 25% off – ExpressVPN: https://expressvpn.com/lexpod and use code LexPod to get 3 months free – Blinkist: https://blinkist.com/lex and use code LEX to get 25% off premium EPISODE LINKS: Mark's Facebook: https://facebook.com/zuck Mark's Instagram: https://instagram.com/zuck Meta AI: https://ai.facebook.com/ PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT &

    Lessons of Greatness: How to Defeat "We're F*cked, It's Over" (WFIO) Moments

    Play Episode Listen Later Mar 1, 2022 12:32

    Starting Greatness with Mike Maples Podcast Notes Key Takeaways Check out Starting Greatness Episode Page & Show NotesRead the full notes @ podcastnotes.orgYour startup will face multiple WFIO moments on the path to greatness...COUNT ON IT. But that doesn't mean you should let these moments get inside your head. In this lesson of greatness, Mike Maples, Jr of FLOODGATE discusses how every startup team MUST be prepared to take the initiative in the crucible of the WFIO moments they will inevitably face. The bright side? You can use these horrible situations as defining moments to show everyone that your startup is destined to defeat the impossible.

    Dr. David Spiegel: Using Hypnosis to Enhance Mental & Physical Health & Performance | Episode 60

    Play Episode Listen Later Feb 24, 2022 112:40

    Huberman Lab Podcast Notes Key Takeaways Stage hypnosis and self-hypnosis are not the same – stage hypnosis is used to perform and frankly make people look foolish; self-hypnosis is a therapeutic tool used to enter a state of focused attentionWe are most hypnotizable between the ages of 6-10 years old; our hypnotizability becomes fixed by our early 20sAbout 1/3 of adults are not hypnotizable, 2/3 are hypnotizable – with about 15% extremely hypnotizable“We underestimate our ability to regulate and change responses – to be cognitively, emotionally, and somatically flexible.” – Dr. David SpiegelDissociation is part of the adaptive strategy in trauma; self-hypnosis allows a safe way to activate state-dependent memory and re-confront event and restructure understandingSelf-hypnosis provides an avenue to lean into phobia and trauma and reconnect the events or objects to more positive associations so other centers of the brain are activatedClinical applications of self-hypnosis: sleep, trauma, pain, phobia, stress, anxiety – and emerging research with grief in cancer patientsEMDR may incorporate some elements of self-hypnosis and suppression of the amygdala which brings people into a calmer state but is likely not as effective as psychotherapy and confronting the issueBreathing is a bridge between conscious and unconscious states: we can modulate our internal state and produce a change we want to see in our body – this can be leveraged to augment hypnosisRead the full notes @ podcastnotes.orgMy guest is Dr. David Spiegel MD, Associate Chair of Psychiatry & Behavioral Sciences, Director of the Center on Stress and Health and Director of the Center for Integrative Medicine at Stanford University School of Medicine. Dr. Spiegel has more than 40 years of clinical and research experience with hypnosis, stress physiology, and psychotherapy. In this episode, we examine the role of clinical hypnosis for the treatment of trauma, chronic pain, anxiety and more. Dr. Spiegel explains how to determine your level of ‘hypnotizability' and provides case studies of incredible successes with hypnosis to treat a variety of ailments. We also discuss how breathing, vision and directed mental focus can modulate internal states and enhance performance. Additionally, we discuss how the adoption of self-hypnosis techniques can reduce stress and enhance sleep in anyone. Dr. Spiegel teaches us how hypnosis works at the neural circuit level to enhance cognitive flexibility. Throughout the episode, Dr. Spiegel summarizes key clinical trials and peer-reviewed findings and resources to work with a trained clinical professional or to do guided self-hypnosis.  Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman Thesis: https://takethesis.com/huberman ROKA - https://roka.com - code "huberman" Our Patreon page https://www.patreon.com/andrewhuberman Supplements from Thorne https://www.thorne.com/u/huberman Huberman Lab Social & Website YouTube Instagram Twitter Facebook Website Newsletter Dr. David Spiegel Links Stanford Center for Stress and Health Support Dr. Spiegel's Research at Stanford (tax-deductible) Dr. Spiegel's Published Work Email: david@reveri.com Article Links Posthypnotic Amnesia in Hypnotizability Assessment: Validation of a New Scoring System for the Hypnotic Induction Profile Post-traumatic stress disorder and cancer Association between Anterior Cingulate Neurochemical Concentration and Individual Differences in Hypnotizability Hypnosis reduces distress and duration of an invasive medical procedure for children Other Links Society for Clinical and Experimental Hypnosis American Society for Clinical Hypnosis Watch Andrew's Hypnosis Session with Dr. Spiegel Reveri website Reveri app (iOS) Join the Waitlist for Reveri for Android Timestamps (00:00:00) Dr. David Spiegel MD, Hypnosis (00:04:16) AG1 (Athletic Greens), Thesis, ROKA (00:09:09) Clinical Hypnosis (00:16:45) Stage Hypnosis (00:20:25) Neurobiology of Hypnosis (00:26:04) ADHD (00:28:22) Hypnosis for Stress & Sleep (00:32:12) Hypnosis to Strengthen Neural Connections (00:37:19) Restructuring Trauma Narratives (00:45:14) Ketamine Therapy (00:50:07) Self-directed Hypnosis, Reveri (00:56:53) Eliminating Obsessive Thoughts, Superstitions (01:01:50) ‘Hypnotizability', the Spiegel Eye-roll Test (01:15:36) EMDR (Eye Movement Desensitization Reprocessing) (01:21:43) Confronting Stress & Trauma (01:27:56) The Mind-Body Connection (01:31:35) Dealing with Grief (01:35:45) Hypnosis in Children & Groups (01:40:06) Drug Therapies & Hypnosis (01:42:39) Breathing Patterns, Peak Performance (01:50:00) Zero-Cost Support, YouTube, Spotify & Apple Reviews, Sponsors, Patreon, Thorne, Instagram, Twitter Title Card Photo Credit: Mike Blabac Disclaimer