The set of life-sustaining chemical transformations within the cells of organisms
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A special episode of the podcast as we visit the presentation day for the Metbionet Metabolic Minds leadership programme to hear about a plan to safeguard the future of specialist biochemistry services in the UK. Dr Rachel Carling explains the programme and then we hear from three of the course candidates, Dr Alana Burns, Annabel Wong and Freya Hassall about their projects on LSD testing, troubleshooting MS/MS and handling measurement uncertainty.
In this episode, Rick Mayo and Matt Helland discuss the science and psychology behind the Alloy method of training frequency.With over three decades of experience, Rick and Matt explain why 2-3 days a week is ideal for the majority of Alloy clients, especially those 40 and older.They break down the physiological and psychological benefits of less frequent, high-quality training, including better strength gains, improved insulin sensitivity, reduced injury risk, and elevated mood.Alloy's structured programming delivers a “minimal effective dose” that respects recovery while maximizing results.Listen in and find out why less is truly more when it comes to lasting fitness.Key TakeawaysIntro (00:00)Benefits of two to three days a week training (04:30)Metabolic and joint health benefits (07:09)Psychological and energy benefits (13:20)Reduced risk of overuse injuries (16:12)Minimal effective dose and programming (17:20)Client education and sales tactics (19:00)Success stories and brand integrity (23:53)Additional Resources:- Alloy Personal Training- Learn About The Alloy Franchise Opportunity---------You can find the podcast on Apple, Google, Spotify, Stitcher, or wherever you listen to podcasts.If you haven't already, please rate and review the podcast on Apple Podcasts!
Send us a textLife Enthusiast Martin Pytella's journey from systems analyst to health engineer began with a catastrophic event - receiving mercury dental fillings that triggered a cascade of health problems, including debilitating back pain that left him crawling on all fours. Applying his analytical skills to his own health crisis, Martin discovered what he calls the "four pillars of disease": toxicity, malnutrition, stagnation, and emotional trauma.In this fascinating conversation, Martin reveals how understanding your metabolic type is crucial for optimal health. He explains that people fall along two continuums - oxidation rate and autonomic nervous system dominance - which determine how different foods affect your body chemistry, weight patterns, and even emotional states. This genetic individuality explains why some thrive on high-protein diets while others need more carbohydrates, depending on factors like thyroid or adrenal dominance.The discussion dives deep into how ancestral diets shaped our genetic adaptations, from Norwegian populations dependent on fish and fermented foods to tropical cultures thriving on fruit-based diets. Martin explains why the standard American diet creates universal harm through refined ingredients, damaged oils, and glyphosate-contaminated GMO foods. He connects these industrial food problems to larger systemic issues, noting how agricultural subsidies make unhealthy foods artificially cheap while creating massive healthcare costs.Through his companies Life Enthusiast and Exsula, Martin offers solutions including an advanced metabolic typing test and superfood blends containing up to 350 ingredients micronized for maximum absorption. His approach emphasizes personalized nutrition and detoxification rather than one-size-fits-all medicine. As Martin puts it, "your headache isn't caused by an Excedrin deficiency" - true healing requires addressing root causes unique to each individual.Ready to discover your metabolic type and take control of your health? Visit Life-Enthusiast.com to take the free metabolic typing quiz and explore superfood solutions designed to fill the nutritional gaps left by Support the showSponsor Affiliates Empowering Wellness Through Evidence-Based Education https://www.atecam.com/ Get YOUR Own Joburg Protein Snacks Discount Code: Damaris15 Or Damaris18 Feeling need to Lose Weight & Become metabolically Healthy GET METABOLIC COURSE GLP 1 REseT This course is designed for individuals looking to optimize their metabolic health through integrative and functional medicine approaches. Whether you're on a GLP-1 medication or seeking natural ways to enhance your metabolic function, this course provides actionable steps, expert insights, and a personalized roadmap sustainable wellness. Are you feeling stressed, tired, or Metabolism imbalanced? Take advantage of our free mindful steps to help improve your well-being.ENJOY ONE OF our Books Mindful Ways Health Wealth & Life https://stan.store/Mindfullyintegrative Join Yearly membership ALL IN O...
Leveling Up: Creating Everything From Nothing with Natalie Jill
What if the free solution to your stress, anxiety, and increased cortisol has been right under your nose this whole time? Most women in midlife accept stress, poor sleep, and declining energy as inevitable parts of aging. But what if I told you that something you do 23,000 times a day—without thinking about it—holds the free key to transforming your nervous system, improving your sleep, extending your life, and even preventing dental problems? Metabolic health expert Sachin Patel reveals the shocking connection between how you breathe and virtually every other aspect of your health. You'll discover why 66% of people are sabotaging their sleep every single night, how mouth breathing is the #1 cause of cavities (not sugar!), and the simple technique that can shift you from chronic stress to deep relaxation in just minutes. Sachin shares the fascinating science behind breath as the "steering wheel of your nervous system" and teaches practical techniques you can use immediately to read other people's stress levels, calm your own anxiety, and optimize your recovery. We dive deep into the sympathetic versus parasympathetic nervous system, the hidden epidemic of mouth breathing, and why your ancestors had perfect teeth without ever seeing a dentist. If you've been struggling with anxiety, poor sleep, or feeling stuck in survival mode, this conversation will give you the tools to literally breathe your way to better health. Get ready to discover the most powerful (and free) tool you already own for transforming your midlife wellness journey. Catch the full episode on YOUTUBE HERE: https://bit.ly/MidlifeConversationsYouTube Learn More About Sachin Patel: https://www.instagram.com/thesachinpatel http://breathworkwithsachin.com.com Free Gifts for being a listener of Midlife Conversations! Mastering the Midlife Midsection Guide: https://theflatbellyguide.com/ Age Optimizing and Supplement Guide: https://ageoptimizer.com Thank you to our show sponsors! AEGIS: Go to https://Aegisformulas.com and use code NatalieJill to get 10% off your next order LEELA QUANTUM: Get 10% off your first Leela order with the code NatalieJill at checkout at https://midlifeconversations.com/leela Connect with me on social media! Instagram: www.Instagram.com/Nataliejllfit Facebook: www.Facebook.com/Nataliejillfit For advertising inquiries: https://www.category3.ca/ Disclaimer: Information provided in the Midlife Conversations podcast is for informational purposes only. This information is NOT intended as a substitute for the advice provided by your physician or other healthcare professional. Do not use the information provided in this podcast for diagnosing or treating a health problem or disease, or prescribing medication or other treatment. Always speak with your physician or other healthcare professional before making any changes to your current regimen. Information provided in this podcast and the use of any products or services related to this podcast does not create a client-patient relationship between you and the host of Midlife Conversations or you and any doctor or provider interviewed and featured on this show. Information and statements may have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent ANY disease. Advertising Disclosure: Some episodes of Midlife Conversations may be sponsored by products or services discussed during the show. The host may receive compensation for such advertisements or if you purchase products through affiliate links. Opinions expressed about products or services are those of the host and/or guests and do not necessarily reflect the views of any sponsor. Sponsorship does not imply endorsement of any product or service by healthcare professionals featured on this podcast.
Many individuals start the journey towards their transformation to achieve a specific aesthetic goal. Hair is a very large component to that and a good amount are struggling with hair loss in some fashion. Today's episode will cover the 3 specific types of hair loss, potential treatments and solutions, and more! Topics include: - Chasing Aesthetics and The Importance of Hair- 3 Specific Types of Hair Loss- The Truth about Hair Growth- Androgenetic Alopecia- Potential Treatments and Solutions- Alternative Therapies- Female Pattern Baldness- Alopecia Areata- Autoimmune Considerations---------- My Live Program for Coaches: The Functional Nutrition and Metabolism Specialization www.metabolismschool.com---------- [Free] Metabolism School 101: The Video Serieshttp://www.metabolismschool.com/metabolism-101----------Subscribe to My Youtube Channel: https://youtube.com/@sammillerscience?si=s1jcR6Im4GDHbw_1----------Grab a Copy of My New Book - Metabolism Made Simple---------- Stay Connected: Instagram: @sammillerscienceYoutube: SamMillerScience Facebook: The Nutrition Coaching Collaborative CommunityTikTok: @sammillerscience----------“This Podcast is for general informational purposes only and does not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast and the show notes or the reliance on the information provided is to be done at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment and is for educational purposes only. Always consult your physician before beginning any exercise program and users should not disregard, or delay in obtaining, medical advice for any medical condition they may have and should seek the assistance of their health care professionals for any such conditions. By accessing this Podcast, the listener acknowledges that the entire contents and design of this Podcast, are the property of Oracle Athletic Science LLC, or used by Oracle Athletic Science LLC with permission, and are protected under U.S. and international copyright and trademark laws. Except as otherwise provided herein, users of this Podcast may save and use information contained in the Podcast only for personal or other non-commercial, educational purposes. No other use, including, without limitation, reproduction, retransmission or editing, of this Podcast may be made without the prior written permission of Oracle Athletic Science LLC, which may be requested by contacting the Oracle Athletic Science LLC by email at operations@sammillerscience.com. By accessing this Podcast, the listener acknowledges that Oracle Athletic Science LLC makes no warranty, guarantee, or representation as to the accuracy or sufficiency of the information featured in this Podcast."
In today's episode, I am breaking down metabolic mapping and how to figure out your metabolic type so that you can apply effective nutritional changes that work for you to improve your fitness and your body composition!Ways to work with me:https://myfitbodyrx.com/programsJoin my free nutrition group :https://www.facebook.com/share/g/19ZEfSgcfX/ Follow me on IG:https://www.instagram.com/cherylnasso
THE EMBC NETWORK featuring: ihealthradio and worldwide podcasts
In this episode of The Headache Doctor Podcast, Dr. Taves welcomes Dr. Liora Mor, a specialist in metabolic and women's health, for an engaging discussion on natural medicine and holistic approaches to migraine management. Dr. Liora shares her personal journey to practicing natural medicine and offers invaluable insights into addressing migraine triggers and optimizing overall well-being. Dr. Liora shares practical tips for identifying and eliminating migraine food triggers, emphasizing the importance of gut health, sleep hygiene, and stress management in migraine prevention. This episode also delves into strategies for reducing inflammation, incorporating movement into daily routines, and crafting personalized nutrition plans to support migraine management. Dr. Liora's expertise shines through as she empowers listeners with actionable advice and evidence-based strategies for achieving optimal health and wellness. If you are interested in connecting with Liora- check out https://theorganiccure.com Novera: Headache Center
On this Part 2 episode, co-hosts Dr. Tania Cubitt and Katy Starr continue their conversation with Dr. Erica Macon, assistant professor of equine science at Texas A&M University, diving deeper into practical nutrition and management for horses with PPID and insulin dysregulation, including:The results of Dr. Macon's study on Standlee pelleted forage and insulin responseWhether feeding one pound of ration balancer at once could trigger a laminitic episodeWhy feeding lean metabolic horses is more complex than it seemsWhat recent research says about seasonal spikes in insulin and winter laminitis risksThey also discuss the importance of building a trusted horse care team, realistic timelines for results, and how small management shifts can make a big difference in long-term health.
Save 20% on all Nuzest Products WORLDWIDE with the code MIKKIPEDIA at www.nuzest.co.nz, www.nuzest.com.au or www.nuzest.com This week on the podcast, Mikki speaks to Dr Sarah Hancock, a public health researcher whose work sits at the powerful intersection of oral health and metabolic disease. In this conversation, Sarah unpacks the often-overlooked links between what's happening in our mouths and what's unfolding systemically in the body.They explore how gum disease and blood sugar dysregulation are deeply intertwined, why your dentist might be the first person to flag insulin resistance, and how the microbiome of the mouth plays a much bigger role in chronic disease than we've given it credit for.Sarah also challenges conventional public health approaches which you'll find super interesting.This is an eye-opening episode for anyone interested in prevention, systems thinking, and redefining the silos of health.https://drsarahhancock.com/Dr Sarah Hancock is a public health researcher. She has a PhD in public health: her research interests focused on the role of nutrition in oral health and general health, and how to design nutrition interventions to improve population health.Sarah is an advocate for dietary lifestyles incorporating a whole food eating pattern that minimises the intake of highly refined, ultra-processed foods for the prevention of chronic diet-related disease. She currently works as an analyst at the School of Public Health at the University of Adelaide in South Australia.https://pubmed.ncbi.nlm.nih.gov/34959913/https://pubmed.ncbi.nlm.nih.gov/36296949/https://pubmed.ncbi.nlm.nih.gov/30318791/ Curranz Supplement: Use code MIKKIPEDIA to get 20% off your first order - go to www.curranz.co.nz or www.curranz.co.uk to order yours Contact Mikki:https://mikkiwilliden.com/https://www.facebook.com/mikkiwillidennutritionhttps://www.instagram.com/mikkiwilliden/https://linktr.ee/mikkiwilliden
THE EMBC NETWORK featuring: ihealthradio and worldwide podcasts
In this episode of The Headache Doctor Podcast, Dr. Taves welcomes Dr. Liora Mor, a specialist in metabolic and women's health, for an engaging discussion on natural medicine and holistic approaches to migraine management. Dr. Liora shares her personal journey to practicing natural medicine and offers invaluable insights into addressing migraine triggers and optimizing overall well-being. Dr. Liora shares practical tips for identifying and eliminating migraine food triggers, emphasizing the importance of gut health, sleep hygiene, and stress management in migraine prevention. This episode also delves into strategies for reducing inflammation, incorporating movement into daily routines, and crafting personalized nutrition plans to support migraine management. Dr. Liora's expertise shines through as she empowers listeners with actionable advice and evidence-based strategies for achieving optimal health and wellness. If you are interested in connecting with Liora- check out https://theorganiccure.com Novera: Headache Center
Dr. Christopher Palmer is a friend and regular guest on this program and he never disappoints. This week he takes us on a fascinating journey through the groundbreaking connection between metabolism and mental health, revealing how the foods we eat profoundly impact not just our bodies but our minds. As a Harvard psychiatrist and director of the Metabolic and Mental Health Program at McLean Hospital, Chris shares compelling evidence that many psychiatric conditions may fundamentally be disorders of brain energy.The conversation opens with alarming statistics about our growing mental health crisis - from quadrupling autism rates to skyrocketing depression and anxiety - and connects these trends to parallel increases in metabolic diseases like diabetes and obesity. Chris explains how these seemingly separate epidemics share common biological roots in cellular energy production.Most powerfully, Chris shares transformative case studies from his clinical practice, including a patient with treatment-resistant schizoaffective disorder whose hallucinations and delusions improved dramatically on a ketogenic diet. These experiences aren't isolated incidents but reflect a growing body of research suggesting ketogenic diets can beneficially alter brain chemistry by improving mitochondrial function - the cellular powerhouses responsible for energy production.The discussion extends beyond serious mental illness to everyday struggles like burnout, anxiety, and depression. An orthopedic surgeon contemplating early retirement due to severe burnout completely revitalized his passion for medicine through metabolic interventions - highlighting how energy deficits at the cellular level manifest as psychological symptoms that conventional treatments often fail to address.Visit brainenergy.com to access free resources, take Dr. Palmer's self-assessment, and learn more about the revolutionary field of metabolic psychiatry that's offering new hope to millions suffering from treatment-resistant mental health conditions.This episode is sponsored by Rio.life which emphasizes metabolically healthy food choices in their programs. I am an advisor to Rio but I only advise companies that I believe in and would use for myself and my family. brainenergy.com rio.lifeLies I Taught In Medical School : Free sample chapter - https://www.robertlufkinmd.com/lies/Complete Metabolic Heart Scan (20% off 'LUFKIN20') https://www.innerscopic.com/Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin At home blood testing (15% off) https://pathlongevity.com/Mimio Health (15% off 'LUFKIN') https://mimiohealth.sjv.io/c/5810114/2745519/30611 Web: https://robertlufkinmd.com/X: https://x.com/robertlufkinmdYoutube: https://www.youtube.com/robertLufkinmdInstagram: https://www.instagram.com/robertlufkinmd/LinkedIn: https://www.linkedin.com/in/robertlufkinmd/Facebook: https://www.facebook.com/robertlufkinmd Threads: https://www.threads.net/@robertlufkinmdBluesky: ...
Struggling with a sluggish metabolism no matter what you do? Your hormones might hold the answer! Join Dr. Carrie Lam as she breaks down six essential metabolic hormones—like GLP-1 and glucagon—that play a huge role in regulating appetite, blood sugar, and weight. Learn how each one impacts your metabolism and discover what you can do to keep them in balance.Trying to find an integrative medicine or functional medicine doctor who understands what you're going through? Lam Clinic does Telemedicine all over the world and is only a phone call away.1. Educate yourself by visiting our website: www.lamclinic.com2. Call our office at 714-709-8000 to schedule an appointment.FIND US ONLINE HERE:» Website: https://www.lamclinic.com/» Facebook: https://www.facebook.com/lamclinic» Instagram: https://www.instagram.com/lam_clinic/» Tiktok: https://www.tiktok.com/@lamclinic» YouTube: https://www.youtube.com/LAMCLINIC
This week on Fat Science, Dr. Emily Cooper, Andrea Taylor, and Mark Wright explore the concept of “male menopause” and whether it's backed by science. Dr. Cooper breaks down hormonal changes in men, including testosterone decline, metabolic dysfunction, and the myths surrounding andropause. The episode dives into why men and women experience aging differently, how metabolism ties into hormone shifts, and what really happens to male fertility and energy over time. After listening, you'll understand why “male menopause” isn't the full story and what really matters for men's health as they age.Key Takeaways:There's no sudden “male menopause”—testosterone declines gradually in men, unlike the rapid hormonal changes seen in female menopause.Metabolic dysfunction can suppress testosterone in men, leading to fatigue, muscle loss, and changes in body fat distribution.Converting testosterone to estrogen in belly fat can further suppress testosterone, creating a cycle that impacts energy and mood.Testosterone therapy might be beneficial for some men with low levels, but should always be guided by a healthcare provider after thorough evaluation.Most supplements marketed to “boost testosterone” are unproven and potentially unsafe—focus on medical advice and proper testing.Personal Stories & Practical Advice:Mark shares his journey with testosterone treatment and how restoring balance improved his mood and energy.Andrea and Dr. Cooper discuss the importance of understanding individual lab results, getting the full metabolic picture, and consulting with primary care providers before considering hormone therapy.Resources:Connect with Dr. Emily Cooper on LinkedIn.Connect with Mark Wright on LinkedIn.Connect with Andrea Taylor on Instagram.Fat Science is a podcast on a mission to explain where our fat really comes from and why it won't go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn't a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.If you have a question for Dr. Cooper, a show idea, feedback, or just want to connect, email us at info@diabesityinstitute.org or dr.c@fatsciencepodcast.com.Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/
Did you know that one 20-ounce soda can pack more sugar than five donuts—and still leave you hungry? In this episode, I unpacked the deceptively sweet world of sugar-sweetened beverages from sodas and sweet teas to fruit juices and even those “healthy” smoothies. I busted eight common myths that might be sabotaging your wellness journey without you even realizing it. We talked about how liquid calories sneak past your hunger cues, spike blood sugar, fuel cravings, and trigger fat storage. I broke down why fruit juice isn't the same as whole fruit, why diet sodas and energy drinks aren't a free pass, and why even your favorite boba tea might be more dessert than drink. So whether you're sipping flavored coffee or reaching for coconut water, it's time to start reading those labels. My challenge to you? Swap one sugary drink a day for water or an unsweetened alternative, your body will thank you for it. Ready to take control of your cravings, boost your energy, and finally see results on the scale? Tune in now to uncover the hidden truths about sweetened drinks and start making smarter choices that truly support your health goals! Episode Highlights: The hidden impact of sugar-sweetened beverages on weight gain and metabolic health Why liquid calories don't satisfy hunger and often lead to overeating Eight common myths about sweet drinks—busted with science The truth about fruit juice, diet sodas, smoothies, and boba tea How sweet drinks spike blood sugar, insulin, and fat storage Smarter alternatives to hydrate without sabotaging your health Practical tips to reduce sweet drink intake and improve energy, mood, and weight loss Connect with Dr. Alicia Shelly: Website | drshellymd.com Facebook | www.facebook.com/drshellymd Instagram | @drshellymd Linked In | www.linkedin.com/in/drshellymd Twitter | @drshellymd About Dr. Alicia Shelly Dr. Alicia Shelly was raised in Atlanta, GA. She received her Doctorate of Medicine from Case Western Reserve University School of Medicine in Cleveland, OH. Dr. Shelly has been practicing Primary Care and Obesity medicine since 2014. In 2017, she became a Diplomat of the American Board of Obesity Medicine. She is the lead physician at the Wellstar Medical Center Douglasville. She started a weekly podcast & Youtube channel entitled Back on Track: Achieving Healthy Weight loss, where she discusses how to get on track and stay on track with your weight loss journey. She has spoken for numerous local and national organizations, including the Obesity Medicine Association, and the Georgia Chapter of the American Society of Metabolic and Bariatric Surgeons. She has been featured on CNN, Fox 5 News, Bruce St. James Radio show, Upscale magazine, and Shape.com. She was named an honoree of the 2021 Atlanta Business Chronicle's 40 under 40 award. She also is a collaborating author for the, “Made for More: Physician Entrepreneurs who Live Life and Practice Medicine on their own terms''. Resources: FREE! Discover the 5 Reasons Your Weight-Loss Journey Has Gotten Derailed (And How To Get Back On Track!)
Dr. Stephen LeBlanc of the Ontario Veterinary College at the University of Guelph joins Dr. Phil Cardoso of the University of Illinois for a chat about metabolic disorders and fertility.Links to publications mentioned in this episodeDairy Cattle Fertility (FE20)https://hoards.com/article-27434-dairy-cattle-fertility-(fe20).htmlBook details:121 pages8.5 x 11 inchesSoftcover, perfect boundFull colorISBN 978-0-9960753-3-6Copyright 2020Jessica Gordon papers on ketosis:Gordon et al. 2017, Effects of a combination butaphosphan and cyanocobalamin product and insulin on ketosis resolution and milk production.DOI: 10.3168/jds.2016-11925https://www.journalofdairyscience.org/article/S0022-0302(17)30149-2/fulltextGordon et al. 2013, Ketosis treatment in lactating dairy cattle. DOI: 10.1016/j.cvfa.2013.03.001https://www.sciencedirect.com/science/article/abs/pii/S0749072013000285?via%3DihubPascottini and LeBlanc 2020, Metabolic markers for purulent vaginal discharge and subclinical endometritis in dairy cows.DOI: 10.1016/j.theriogenology.2020.06.005https://pubmed.ncbi.nlm.nih.gov/32622204/Stephanie's (my student) video on Metricheck toolhttps://www.youtube.com/watch?v=jIhd8buSpHU&t=160sLeBlanc 2014, Reproductive tract inflammatory disease in postpartum dairy cows. DOI: 10.1017/S1751731114000524https://www.cambridge.org/core/journals/animal/article/reproductive-tract-inflammatory-disease-in-postpartum-dairy-cows/598913738F82C7FC94A92F60C7C80524New Zealand paper:Burke et al., Relationships between endometritis and metabolic state during the transition period in pasture-grazed dairy cows.https://pubmed.ncbi.nlm.nih.gov/20965352/
Today, we're talking to the men out there — and the women who love them — about a topic that's not getting enough airtime:
Get My Book On Amazon: https://a.co/d/avbaV48Download The Peptide Cheat Sheet: https://peptidecheatsheet.carrd.co/Download The Bioregulator Cheat Sheet: https://bioregulatorcheatsheet.carrd.co/
BUFFALO, NY — June 12, 2025 — A new #research paper was #published in Aging (Aging-US) Volume 17, Issue 5, on May 3, 2025, titled “APOE genotype and biological age impact inter-omic associations related to bioenergetics.” In this study, led by first author Dylan Ellis and corresponding author Noa Rappaport from the Institute for Systems Biology, researchers discovered that different versions of the APOE gene—particularly ε2 and ε4—are linked to metabolic patterns associated with aging and Alzheimer's disease risk. Both variants were linked to increased levels of diacylglycerols, a type of fat molecule connected to insulin resistance and inflammation, suggesting shared disruptions in how the body regulates energy. The research team analyzed data from over 2,200 adults without an Alzheimer's diagnosis, exploring how APOE genotypes influence biological age, a measure of health that reflects how quickly or slowly someone is aging at a cellular level. They found that the same metabolic disturbances seen in ε2 carriers were also present in people considered biologically older, revealing unexpected overlap between genetic risk and aging-related metabolic changes. To examine these connections in more detail, the researchers used a multi-omics approach, combining blood-based metabolism and protein data, gut bacteria analysis from stool samples, and clinical chemistry data. This method allowed them to map how genetic differences and biological aging affect the body's energy systems. They observed altered connections between glucose metabolism, inflammatory markers, and key molecules that play roles in energy production, indicating early disruptions that could contribute to age-related diseases. One of the study's surprising findings was that the ε2 variant, usually associated with longer life and reduced Alzheimer's risk, showed metabolic traits similar to those found in insulin-resistant individuals. This suggests that ε2 may carry metabolic disadvantages earlier in life, with its protective effects becoming more pronounced later. Conversely, ε4—linked to greater Alzheimer's risk—may exert its influence based on interactions with lifestyle factors like diet, sex, and overall health status. “‘Omics association patterns of ε2-carriers and increased biological age were also counter-intuitively similar, displaying significantly increased associations between insulin resistance markers and energy-generating pathway metabolites.” By identifying these shared biological signatures, this study offers a new framework for understanding how genes and metabolism work together to influence aging. These findings could support more personalized health strategies aimed at delaying biological aging and reducing the risk of chronic diseases. As aging populations grow worldwide, understanding these pathways is essential to improving healthspan. DOI - https://doi.org/10.18632/aging.206243 Corresponding author - Noa Rappaport - noa.rappaport@isbscience.org Video short - https://www.youtube.com/watch?v=75hZQoO5U0U Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206243 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, apolipoprotein E (APOE), biological age, metabolism, Alzheimer's disease (AD), insulin resistance To learn more about the journal, please visit our website at https://www.Aging-US.com and connect with us on social media at: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM
Today's wisdom comes from The Metabolic Approach to Cancer by Dr. Nasha Winters & Jess Higgins Kelley, MNT. If you're loving Heroic Wisdom Daily, be sure to subscribe to the emails at heroic.us/wisdom-daily. And… Imagine unlocking access to the distilled wisdom form 700+ of the greatest books ever written. That's what Heroic Premium offers: Unlimited access to every Philosopher's Note. Daily inspiration and actionable tools to optimize your energy, work, and love. Personalized coaching features to help you stay consistent and focused Upgrade to Heroic Premium → Know someone who'd love this? Share Heroic Wisdom Daily with them, and let's grow together in 2025! Share Heroic Wisdom Daily →
Metabolic dysfunction-associated steatotic liver disease (MASLD), also known as fatty liver disease, is a chronic liver condition that affects nearly 1 in 3 people worldwide. It is closely linked to obesity, type 2 diabetes, and metabolic syndrome. Unchecked, it can progress to a more severe form of disease called Metabolic Dysfunction-Associated Steatohepatitis (MASH). Prognosticating the risk of disease progression in MASLD and MASH has traditionally involved liver biopsy, a process that involves removing a tissue sample with a hollow needle and then examining the sample under a microscope to diagnose and stage disease. However, biopsy has many limitations. Additionally, drug development for MASLD and MASH has proceeded slowly in part due to a reliance on liver biopsy to determine drug efficacy.Recently, increasing evidence is suggesting that non-invasive options, for example, imaging examinations along with blood tests that assess likelihood of disease progression such as the Enhanced Liver Fibrosis (ELF) Test, may effectively reduce the need for the more invasive alternative. Key experts in MASLD and MASH share their perspectives about how clinical evidence supports a shift in the way patients with MASLD and MASH could be evaluated in clinical practice and in research.Host Matt Gee, Director of Collaborations and External Engagement at Siemens Healthineers, is joined by Prof. William Rosenberg, Deputy Director of the Institute for Liver and Digestive Health at University College London as well as Dr. Veronica Miller, Director of the Forum for Collaborative Research at the University of California, Berkeley School of Public Health; Dr. Arun Sanyal, Professor of Medicine, Physiology, and Molecular Pathology in the Division of Gastroenterology at Virginia Commonwealth University; and Dr. Michelle Long, International Medical Vice President of Metabolic Dysfunction-Associated Steatohepatitis at Novo Nordisk and Associate Professor in the Section of Gastroenterology and Hepatology at Boston University.What you'll learn in this episode:Liver biopsy creates several obstacles for patients and has limitationsDrug development faces challenges by the reliance on biopsy as a measure of treatment effectivenessNon-invasive tools may be suitable alternatives to liver biopsy both in clinical practice and in drug developmentConnect with Matt GeeLinkedIn Connect with Veronica MillerLinkedInConnect with William RosenbergLinkedInConnect with Michelle LongLinkedInConnect with Arun SanyalVCU.edu Hosted on Acast. See acast.com/privacy for more information.
Belly fat isn't about calories—it's about inflammation, insulin resistance, and stress. In this episode, Ben Azadi reveals the silent root causes of stubborn belly fat that most doctors overlook, including seed oils, toxins, processed carbs, sleep deprivation, blue light, and chronic stress. He also shares powerful strategies to reverse these issues, heal your metabolism, and lose fat without counting calories. Highlights: The #1 hidden belly fat trigger in 80% of foods
Feel Better. Live Free. | Health & Wellness Creating FREEDOM for Busy Women Over 40
Swimsuits. Tank tops. Pool parties. Feeling anxious just thinking about them?What if this summer could be different? In this episode, Ruth breaks down the exact 6-step plan that helped her lose 49 pounds and keep it off for years—without starvation, without misery, and without drugs like Ozempic.Learn why summer is actually the perfect time to transform your health, how to enjoy social events without sabotaging your progress, and the surprising truth about electrolytes that could make or break your success.If you're ready to make this the summer that changes everything, this episode is your blueprint. Stop hiding, stop struggling, and start healing.This is your summer of YOU.----------To learn more and get started on making this the summer of you, be sure to visit thinlicious.com/program.And if you haven't already, don't forget to grab our free guide, "Flip the Switch," at thinlicious.com/guide.
This week on Fat Science, Dr. Emily Cooper, Andrea Taylor, and Mark Wright explore the expanding world of telehealth in treating metabolic issues. Dr. Cooper sheds light on both the promise and pitfalls of accessing medications like GLP-1s through online platforms. The episode dives into the effectiveness of patient-provider relationships, the importance of comprehensive and personalized care, and the potential red flags in impersonal telehealth services. After listening, you'll understand the benefits of telehealth and why thoughtful, thorough medical guidance is crucial for metabolic health.Key Takeaways:Telehealth has improved accessibility and convenience for metabolic care, but not all platforms offer the same quality of support.The lack of personalized interaction and lab-based assessments in many telehealth services can pose risks to patient health.Quick, transactional telehealth models often prioritize medication sales over holistic care and ongoing patient monitoring.Comprehensive care requires detailed history-taking, follow-up, and lab work—elements often missing in mass-market telehealth.Listeners should watch for red flags such as no direct provider interaction, absence of lab testing, and subscription models tied to product sales.Personal Stories & Practical Advice:Andrea reflects on her own journey and the difference a dedicated, whole-person approach made to her health.Dr. Cooper shares her experience testing a mass-market telehealth site, exposing the superficial nature of some programs.The panel urges listeners to seek out board-certified providers and reputable telehealth organizations for genuine care.Link to US National telehealth clinics with Board Certified Obesity Medicine providers: Knownwell (non-affiliated)Resources:Connect with Dr. Emily Cooper on LinkedIn.Connect with Mark Wright on LinkedIn.Connect with Andrea Taylor on Instagram.Fat Science is a podcast on a mission to explain where our fat really comes from and why it won't go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn't a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.If you have a question for Dr. Cooper, a show idea, feedback, or just want to connect, email us at info@diabesityinstitute.org ordr.c@fatsciencepodcast.com.Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/
Did you know a daily weight loss pill might soon replace weekly injections for managing obesity? In this episode, I explore the exciting new development of a once-daily oral weight loss medication, oral semaglutide 50mg highlighting results from the OASIS 1 trial. With this, I explain how this pill could be a game-changer for people who are hesitant about injections like Wegovy or Zepbound. I break down how semaglutide works as a GLP-1 receptor agonist, the phases of drug development, and the impressive trial results showing an average 15% body weight loss in participants without diabetes. I also talk about common side effects, the FDA approval timeline, and what this could mean for patients looking for more accessible, convenient weight loss options. Curious about the future of weight loss treatments? Tune in to learn about a groundbreaking pill that could change everything. Episode Highlight: Introduction of oral semaglutide 50mg as a potential weight loss pill Explanation of how semaglutide works as a GLP-1 receptor agonist. Overview of the OASIS 1 phase 3 trial Breakdown of clinical trial phases and FDA approval process. Discussion of side effects Adherence rates and significant weight loss among participants. Insight into future FDA approval timelines and potential market release Importance of combining medication with lifestyle changes Considerations about insurance coverage and patient access Connect with Dr. Alicia Shelly: Website | drshellymd.com Facebook | www.facebook.com/drshellymd Instagram | @drshellymd Linked In | www.linkedin.com/in/drshellymd Twitter | @drshellymd About Dr. Alicia Shelly Dr. Alicia Shelly was raised in Atlanta, GA. She received her Doctorate of Medicine from Case Western Reserve University School of Medicine in Cleveland, OH. Dr. Shelly has been practicing Primary Care and Obesity medicine since 2014. In 2017, she became a Diplomat of the American Board of Obesity Medicine. She is the lead physician at the Wellstar Medical Center Douglasville. She started a weekly podcast & Youtube channel entitled Back on Track: Achieving Healthy Weight loss, where she discusses how to get on track and stay on track with your weight loss journey. She has spoken for numerous local and national organizations, including the Obesity Medicine Association, and the Georgia Chapter of the American Society of Metabolic and Bariatric Surgeons. She has been featured on CNN, Fox 5 News, Bruce St. James Radio show, Upscale magazine, and Shape.com. She was named an honoree of the 2021 Atlanta Business Chronicle's 40 under 40 award. She also is a collaborating author for the, “Made for More: Physician Entrepreneurs who Live Life and Practice Medicine on their own terms''. Resources: FREE! Discover the 5 Reasons Your Weight-Loss Journey Has Gotten Derailed (And How To Get Back On Track!)
Send us a textLily Johnston, MD, MPH, is board-certified in both vascular and general surgery. Dr. Johnston obtained her undergraduate education at Princeton University in New Jersey and received her Medical Doctorate from the University of California, San Diego; she completed her residency in general surgery at the University of Virginia in Charlottesville and then completed a fellowship in vascular surgery at the Mayo Clinic in Rochester, MN.After several years of practicing vascular surgery full-time, Dr. Johnston witnessed too many people losing their limbs and even their lives to preventable and reversible diseases - this inspired her to found Vascular Health Institute in an effort to forward cardiovascular health and wellness. Dr. Johnston has now dedicated her career to addressing the root cause of cardiovascular disease and is passionate about bringing the principles of functional medicine and metabolic health to her patients.Dr. Johnston's clinic: www.nexushealthspan.comDr. Greg's clinic: www.fitrxwellnessok.com
Have you ever wondered why some people exercise religiously and follow all the right diets but still struggle with weight and metabolic health? Dr. Brian Lenzkes, ten-time recipient of San Diego's "Best Doctor" award, reveals the missing pieces in our understanding of metabolic health that might be sabotaging your efforts.Dr. Lenzkes opens up about his personal journey through metabolic dysfunction despite being a practicing physician with all the "right" knowledge. When his blood sugar reached pre-diabetic levels despite regular exercise and following conventional dietary guidance, he knew something fundamental was missing from mainstream medicine's approach.The breakthrough came from an unexpected source—an elderly patient who lost 40 pounds through intermittent fasting. This led Dr. Lenzkes down a path that transformed his medical practice, helping patients come off diabetes medications completely and reverse conditions he once believed were permanent.In this conversation, Dr. Lenzkes delivers several shocking revelations. First, the blood sugar tests your doctor runs might be missing the most important marker of metabolic health—insulin levels. He explains how high insulin can silently damage your body for years before blood sugar numbers ever change. Second, he explains why muscle mass might be the single most important factor for longevity, even more significant than avoiding smoking or drinking. Finally, he demonstrates through patient stories how stress, poor sleep, and even arguments with loved ones can spike blood sugar more dramatically than eating cookies.Whether you're struggling with weight loss plateaus, puzzling blood sugar readings, or just want to understand why conventional medical wisdom keeps failing so many people, Dr. Lenzkes offers practical insights that bridge traditional medicine with cutting-edge lifestyle approaches. His message is ultimately one of hope—that with the right understanding of how our bodies actually work, many of the metabolic conditions considered "chronic" might actually be reversible.Ready to discover what might be missing in your health journey? Listen now to understand the surprising connections between stress, muscle, insulin resistance, and lasting health.Enjoyed this episode? We'd love to hear your thoughts—share your feedback with us here!Florence's courses & coaching programs can be found at:www.FlorenceChristophers.comConnect with Florence on:FACEBOOK | TWITTER | INSTAGRAM | YOUTUBE
This episode is with a good friend and collaborator, Dr. Marco Meucci of COSMED. Marco was formally an Associate Professor in the Public Health and Exercise Science Department at Appalachian State University, where he also served as the Director of their wellness and human performance lab. He now is the Academics Manager for COSMED, an Italian company that “designs, manufactures, and sells worldwide diagnostic medical devices to assess Lung function, Metabolic, and Body Composition.” Marco shares his story and progression as an athlete, student, professor, and leader in academia. We discuss how he made decisions leading to where he is today and how he uses the sparks to create forks in life, then takes the most exciting one. We believe you are going to love the energy and insight this enthusiastic Italian brings to the show. Enjoy!
Let's be honest, perimenopause and menopause are incredibly transformative journeys that NONE of us asked for. So, it's up to us to find meaning and purpose amid these shifts. That's what this episode is all about– finding the power you hold to understand what's really happening in your body at this stage of life. It's time to decode the symptoms you've been told to brush off again and again by your doctor, and take ACTION that changes your health trajectory today, and for all your days to come. In this episode, I'll provide you with the framework for understanding your body in perimenopause and help you take actionable steps to feel more alive and achieve the results you deserve. We're diving into labs, biomarkers, and how to harness this data to become the ultimate CEO of your health, feeling more confident in your body every day. Tune in here and discover how to reclaim your story and feel empowered every step of the way! IN THIS EPISODE Why your metabolic health is key to your overall wellness The 5 biomarkers of optimal metabolic health Navigating the massive knowledge gap in our healthcare system How to avoid chronic complications down the road The three truths you need to know about your metabolic health Understanding your specific lab ranges and analyzing your results Action steps to find out if you're metabolically healthy QUOTES “88% of women over 45 years old will have some level of metabolic dysfunction, and insulin resistance is really the silent force behind 8 out of the 10 top causes of death in the US.” “Metabolic dysfunction and syndrome occur when three or more of the following biomarkers are out of range.” “What a lot of us don't realize is the things that are manifesting in our sixties and seventies really started in our forties. And often they could have been avoided with earlier, more targeted interventions.” RESOURCES MENTIONED The Perimenopause Revolution by Dr. Mariza Snyder: Pre-order your copy here and get IMMEDIATE ACCESS to bonuses like The Perimenopause Power Toolkit, workout videos, recipes & more! www.qualialife.com/drmariza, Coupon Code: ENERGIZED BEAM Minerals: Use code ENERGIZED at checkout for 20% off your first order! RELATED EPISODES #648: This Changes Everything: The Perimenopause Revolution Every Woman Needs Now 595: How to Master Your Metabolism and Reverse Cellular Aging in Midlife + My Best Tips to Thrive with Dr. Mariza 584: The Health Costs of Our Modern Life & How to Start Feeling Better with Dr. Casey Means #541: Why Functional Labs Are a Game Changer for Your Health with Dr. Kela Smith
Explore the science behind the "Sugar Diet," a low-protein, high-carbohydrate or high-fat dietary regimen. We'll discuss how this approach influences metabolic pathways, its potential benefits for fat loss, and the importance of nutrient quality in achieving optimal health outcomes. All things considered, do we recommend anyone utilize this strategy? Tune in to find out! APPLY FOR COACHING: https://www.lvltncoaching.com/1-1-coaching SDE Method app: https://www.lvltncoaching.com/sde-method-app Macros Guide https://www.lvltncoaching.com/free-resources/calculate-your-macros Join the Facebook Community: https://www.facebook.com/groups/lvltncoaching FREE TOOLS to start your health and fitness journey: https://www.lvltncoaching.com/resources/freebies Alessandra's Instagram: http://instagram.com/alessandrascutnik Joelle's Instagram: https://www.instagram.com/joellesamantha?igsh=ZnVhZjFjczN0OTdn Josh's Instagram: http://instagram.com/joshscutnik Timestamps: 00:00 Introduction and Birthday Celebrations 02:57 Understanding the Sugar Diet 05:58 The Science Behind Low Protein Diets 09:56 Critique of the Sugar Diet 12:43 Metabolic Health and Individual Responses 15:51 Long-term Implications of the Sugar Diet 18:50 Conclusion and Final Thoughts 23:38 The Impact of Diet on Health 25:38 Understanding mTOR and AMPK 26:33 Taurine and Its Role in Diet 27:28 The Efficiency of Low Protein Diets 29:24 The Nuances of Dietary Strategies 30:17 Target Audience for New Diets 31:42 The Risks of Misleading Headlines 33:30 The Importance of Metabolic Health 34:46 Navigating the Health and Fitness Industry 36:34 Exploring Nutrient-Dense Carbohydrate Sources 38:24 Limitations of Low Protein Diets 40:11 Long-Term Effects of High Sugar Diets 42:25 Key Takeaways and Recommendations
On this Part 1 episode, co-hosts Dr. Tania Cubitt and Katy Starr have a conversation with Dr. Erica Macon, assistant professor of equine science at Texas A&M University, to talk about the challenges of managing equine metabolic disorders, including:Why horses that appear lean can still be at risk for metabolic issuesThe differences between insulin resistance and insulin dysregulationCommon misconceptions about “low NSC” feedsHow subtle signs like a cresty neck can indicate underlying problems And be sure to tune in to Part 2, which will release June 17th, where Dr. Macon shares the results of how Standlee pelleted forage impacts insulin levels in metabolic horses, potential feed management ideas that could help metabolic horses, and we discuss how and why horses might get laminitis in the winter.
Dr Mrinmayee Takle and Dr Kuntal Sen discuss the challenging dilemma of a child, presenting from infancy with recurrent seizures and three different (wrong) diagnoses including opsoclonus-myoclonus-ataxia syndrome. Read the article: https://doi.org/10.1002/cns3.20098 Mrinmayee Takle, Dhwani Sahjwani, Diana Bharucha-Goebel, Tyler Rapp, Cecilia Bouska, Alexandra Kornbluh, Kuntal Sen
Learn how real healing starts by looking at the whole body not just the symptoms. The focus is on how stress, poor sleep, diet, and gut health all influence daily well-being, from energy levels to mental clarity.It also explores how deeper issues like hormone imbalances, PCOS, or memory problems can sometimes trace back to metabolism and inflammation. The goal is to identify the root cause and make simple, lasting changes for better overall health.Highlights of the Podcast00:04 - What "holistic" actually means01:00 - PTSD and erectile dysfunction connection03:00 - Gut health and stress04:35 - The holistic healing process06:10 - PCOS and insulin resistance09:00 - Dementia and metabolic health11:25 - Metabolic health drives emotional health
Dr. Cate Shanahan, MD, has been studying vegetable oils since 2002. We talked about her background in biochemistry and what plastics have to do with seed oils, Henry Ford's role in the history of seed oils, fatty acid chemistry and oxidation, how to avoid parkinsons and improve your mental health, her thoughts on sugar, fruit, and juice, the Hateful Eight, what Dr. Cate eats in a day, her new book Dark Calories, and more.Audible (Listen to Dark Calories & Other Audiobooks)Try Audible Free for 30 DaysHeadspace (Meditation App)Try it for Free for 14 DaysThrive Market (Organic, Healthy Grocery Delivery)Get $60 in Free GroceriesAquaTru (Premium Water Filters)Get $100 off any AquaTru systemSupport the Podcast Directlypatreon.com/somethingdiffpodWe are supported by these amazing BIG GIVERS:Michael Roy and Mark and Julie CalhounShow Notes: thenuggetclimbing.com/episodes/cate-shanahanNuggets:(00:00:00) – Intro(00:03:56) – Dr. Cate's education background(00:07:52) – Polymerization & seed oils(00:12:46) – Athletic background & health issues(00:15:04) – What a healthy diet really is(00:16:28) – Why do people defend seed oils?(00:27:19) – The smoking analogy(00:30:46) – A brief history of seed oils(00:42:40) – Edward Bernays(00:43:14) – Fatty acid chemistry & oxygen(00:49:30) – Oxidation & oxidative stress(00:56:55) – Rust, autophagy, & chronic disease(01:00:32) – Changing your diet to prevent Parkinson's(01:02:11) – Sugar & refined flour(01:05:51) – Mental health(01:10:41) – Sugar continued(01:14:38) – Fruit, juice, & old food(01:20:56) – The Hateful Eight(01:24:22) – Clean Bite app(01:25:54) – Palm, olive, avocado, & coconut oil(01:27:34) – Adulterated food(01:31:00) – What Dr. Cate eats in a day(01:34:14) – Ancestral eating & Deep Nutrition(01:35:00) – Her next course(01:35:28) – Where to find Dr. Cate
This week on Fat Science, Dr. Emily Cooper, Andrea Taylor, and Mark Wright answer listener questions from around the world about metabolic health. This mailbag episode explores widely-debated topics like “starvation mode,” weight loss plateaus, the relationship between metabolism and cognitive health, cannabis and metabolism, metabolic effects of liposuction, and the latest on GLP-1 medications.Key Takeaways:Dr. Cooper dispels myths around “starvation mode,” citing research on the long-term metabolic impact of dieting and caloric restriction.Weight loss plateaus are often misunderstood—Dr. Cooper explains the natural adaptations behind them and how to assess true progress.Metabolic health plays a major role in brain function, cognitive decline, depression, and dementia prevention.Cannabis affects metabolic pathways in complex ways, with regular use potentially causing negative metabolic effects.Liposuction can trigger metabolic rebound and rapid fat regain for some patients, especially when leptin levels are low.Updates on GLP-1 meds: Liraglutide is available in generic form, but costs fluctuate. New oral and combination therapies are on the horizon.Personal Stories & Practical Advice:Andrea and Mark reflect on their own journeys with dieting, weight plateaus, and medication.Dr. Cooper shares clinical experiences with metabolic rebound after liposuction and ways to navigate pharmacologic treatments.Correction: Lilly has a lower cash pay for Medicare and Medicaid, but Novo Nordisk is not yet.References related to diet-induced metabolic adaptation, also called biological adaptation and defense of body weight. 1. Keys, A., Brozek, J., Henschel, A., Mickelsen, O., & Taylor, H. L. (1950). The Biology of Human Starvation. University of Minnesota Press.2. Dulloo, A. G. (2021). Physiology of weight regain: Lessons from the classic Minnesota Starvation Experiment on human body composition regulation. Obesity Reviews, 22, e13189.3. Müller, M. J., & Bosy-Westphal, A. (2013). Adaptive thermogenesis with weight loss in humans. Obesity, 21(2), 218-228.4. Rosenbaum, M., & Leibel, R. L. (2010). Adaptive thermogenesis in humans. International Journal of Obesity, 34(S1), S47-S55.5. Fothergill, E., Guo, J., Howard, L., Kerns, J. C., Knuth, N. D., Brychta, R., ... & Hall, K. D. (2016). Persistent metabolic adaptation 6 years after "The Biggest Loser" competition. Obesity, 24(8), 1612-1619.6. Johanssen, D. L., Knuth, N. D., Huizenga, R., Rood, J., Ravussin, E., & Hall, K. D. (2012). Metabolic slowing with massive weight loss despite preservation of fat-free mass. Journal of Clinical Endocrinology & Metabolism, 97(7), 2489-2496.7. Sumithran, P., Prendergast, L. A., Delbridge, E., Purcell, K., Shulkes, A., Kriketos, A., & Proietto, J. (2011). Long-term persistence of hormonal adaptations to weight loss. New England Journal of Medicine, 365(17), 1597-1604.8. MacLean, P. S., Bergouignan, A., Cornier, M. A., & Jackman, M. R. (2011). Biology's response to dieting: the impetus for weight regain. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 301(3), R581-R600Resources:Connect with Dr. Emily Cooper on LinkedIn.Connect with Mark Wright on LinkedIn.Connect with Andrea Taylor on Instagram.Fat Science is a podcast on a mission to explain where our fat really comes from and why it won't go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn't a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.If you have a question for Dr. Cooper, email us at info@diabesityinstitute.org or dr.c@fatsciencepodcast.com.Fat Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/
Ben Azadi is a bestselling author, speaker, and founder of Keto Kamp. After overcoming obesity, depression, and pre-diabetes, Ben has dedicated his life to helping others achieve “metabolic freedom” through nutrition, mindset, and faith. With a background in personal training and years of content creation via podcasting, YouTube, and books, his latest work, Metabolic Freedom, blends actionable dietary advice with spiritual and psychological tools for true transformation.Ben Azadi joins the show to unpack his new book Metabolic Freedom, a blueprint for reclaiming your health through ancestral eating, fasting, and radical responsibility. From his personal transformation—losing 80 pounds and reversing pre-diabetes—to helping millions ditch metabolic dysfunction, Ben shares practical strategies for fat loss, healing, and mental clarity. This episode goes beyond macros and protocols—it's about removing interference, building intuition, and stepping into the healthiest version of yourself.What we cover:- The meaning of “metabolic freedom” and why most are in a metabolic prison- The problem with modern healthcare- The power of single-ingredient foods and low-carb nutrition- The impact of thoughts and mindset on metabolismTimestamps:(00:00) — Introduction (01:30) — Why Ben wrote Metabolic Freedom (03:45) — Books vs. fleeting content (06:20) — Simplifying health for the masses (08:15) — America's broken healthcare system (10:00) — Ben's 80-pound weight loss journey (14:40) — Mindset and self-image matter most (20:00) — What metabolic freedom really means (29:00) — Three nutrition steps to start today (39:15) — Vitamin G: the power of gratitude*** LINKS***Check out our supplement company - Noble Origins- 100% grass-fed beef protein with added collagen, colostrum and organs- Use code MAFIA25 for 25% OFF your orderCheck out our Newsletter - Food for Thought - to dramatically improve your health this year!Join The Meat Mafia community Telegram group for daily conversations to keep up with what's happening between episodes of the show.Connect with Ben:InstagramOrder Metabolic Freedom HereConnect with Brett:InstagramConnect with Harry:InstagramXConnect with Meat Mafia:Instagram - Meat MafiaX - Meat MafiaYouTube - Meat MafiaConnect with Noble Protein:Website - Noble ProteinX - Noble ProteinInstagram - Noble ProteinAFFILIATESLMNT - Electrolyte salts to supplement minerals on low-carb dietThe Carnivore Bar - Use Code 'MEATMAFIA' for 10% OFF - Delicious & convenient Pemmican BarPerennial Pastures - Use CODE 'MEATMAFIA' 10% OFF - Regeneratively raised, grass-fed & grass-finished beef from California & MontanaFarrow Skincare - Use CODE 'MEATMAFIA' at checkout for 20% OFFHeart & Soil - CODE ‘MEATMAFIA' for 10% OFF - enhanced nutrition to replace daily vitamins!Carnivore Snax - Use CODE 'MEATMAFIA' Crispy, airy meat chips that melt in your mouth. Regeneratively raised in the USA.Pluck Seasoning - 15% OFF - Nutrient-dense seasoning with INSANE flavor! Use CODE: MEATMAFIAWe Feed Raw 25% OFF your first order - ancestrally consistent food for your dog! Use CODE 'MEATMAFIA'Fond Bone Broth - 15% OFF - REAL bone broth with HIGH-QUALITY ingredients! It's a daily product for us! Use CODE: MAFIAMaui Nui- 15% OFF. Use CODE: MEATMAFIA
Back in Episode 371, I introduced a perfect storm client case AKA where gut and hormone dysfunction collide and on today's episode, I wanted to extend and expand that conversation. We'll be looking at some potential health issues, key considerations, and more when it comes to being in a deficit, using SHREDS, examining micronutrient status, and more! Topics include: - Compounding Health Issues in a Deficit Phase- Part 2 To The Perfect Storm Client- Key Considerations- Women's Sensitivity to Energy Balance Changes- Iron Status and Deficiencies- Examining SHREDS- Micronutrient Status Considerations- Recapping Common Issues- Preventable Strategies- The FNMS Program---------- My Live Program for Coaches: The Functional Nutrition and Metabolism Specialization www.metabolismschool.com---------- [Free] Metabolism School 101: The Video Serieshttp://www.metabolismschool.com/metabolism-101----------Subscribe to My Youtube Channel: https://youtube.com/@sammillerscience?si=s1jcR6Im4GDHbw_1----------Grab a Copy of My New Book - Metabolism Made Simple---------- Stay Connected: Instagram: @sammillerscience Youtube: SamMillerScience Facebook: The Nutrition Coaching Collaborative Community TikTok: @sammillerscience ----------“This Podcast is for general informational purposes only and does not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast and the show notes or the reliance on the information provided is to be done at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment and is for educational purposes only. Always consult your physician before beginning any exercise program and users should not disregard, or delay in obtaining, medical advice for any medical condition they may have and should seek the assistance of their health care professionals for any such conditions. By accessing this Podcast, the listener acknowledges that the entire contents and design of this Podcast, are the property of Oracle Athletic Science LLC, or used by Oracle Athletic Science LLC with permission, and are protected under U.S. and international copyright and trademark laws. Except as otherwise provided herein, users of this Podcast may save and use information contained in the Podcast only for personal or other non-commercial, educational purposes. No other use, including, without limitation, reproduction, retransmission or editing, of this Podcast may be made without the prior written permission of Oracle Athletic Science LLC, which may be requested by contacting the Oracle Athletic Science LLC by email at operations@sammillerscience.com. By accessing this Podcast, the listener acknowledges that Oracle Athletic Science LLC makes no warranty, guarantee, or representation as to the accuracy or sufficiency of the information featured in this Podcast."
Download the Cancer Terrain TrackerUnderstanding Cancer: Inherited Risks, Biopsy Concerns, and the Impact of EnvironmentThis episode delves into common questions about cancer, addressing misconceptions about genetic predispositions and the impact of environmental factors. Topics include the role of epigenetics, the potential risks of biopsies, the concept of metabolic cancer theory, and how routine labs might hint at early cancer signs. The speaker emphasizes the importance of becoming one's own health advocate and understanding the broader context of cancer development and prevention. Additionally, various emerging diagnostic technologies are discussed as potentially safer alternatives to traditional biopsies.00:00 Introduction: The Reality of Cancer01:43 Understanding Genetic Risks03:12 Epigenetics and Environmental Factors07:18 Inherited Trauma and Cancer09:43 Biopsies and Cancer Spread21:55 Metabolic vs. Genetic Theories of Cancer26:34 Detecting Cancer in Routine Labs30:50 Conclusion and Resources
David Gornoski sits down with Prof. Thomas Seyfried and Dr Pierre Kory for a discussion on why cancer isn't a genetic disease, the untold damage from standardized treatment, a new paradigm in oncology, treatment with repurposed drugs, what needs to happen at the regulatory scene, and more. Follow Prof. Thomas Seyfried on X here. Follow Dr Pierre Kory on X here. Follow David Gornoski on X here. Visit aneighborschoice.com for more
Narcissistic Abuse, Food Noise & Metabolic Disorder In this episode, I'm joined by Nikki Antonaccio, who shares how surviving narcissistic abuse as a child shaped everything from her relationship with food to her metabolism and how that trauma rewired her behaviour in ways that didn't make sense until much later.We talk about how trauma from narcissistic abuse doesn't just live in the mind, it lodges itself in the body, in the nervous system, in metabolism. For Nikki, it showed up as people-pleasing, chronic stress, disordered eating and shutdown and it's not a lack of willpower. It's survival.As Nikki shares her personal story, and how this led her to become the UK's leaving Trauma Informed Nutritionist and I reflect on how she helped me see my own eating patterns in a different light. I wasn't just making poor choices, my metabolism was shaped by what I'd lived through.We talk about everything, trauma, food, shame, nervous system, survival, the future of metabolic healing and why healing and losing weight after narcissistic abuse is so much deeper than calories in vs. calories out.Explore Nikki's work here:https://nikkiantonaccioonlinecoachingltd.dropfunnelsme.com/bvy-new24/bvy-new24Don't ever be alone in your journey and make sure you come and join my private Facebook community, No Visible Bruises where you can connect with other survivors of narcissistic abuse, domestic abuse and coercive control:https://www.facebook.com/groups/novisiblebruisesDisclaimer:The views and opinions shared in this podcast are those of the individuals involved and are intended for informational and educational purposes only. They do not substitute professional or medical advice. If you've been affected by anything discussed in today's episode, please consider reaching out to a qualified healthcare provider or mental health professional for support. You're not alone, and help is always available
Can ketogenic therapy help reduce or even resolve symptoms of obsessive compulsive disorder (OCD)? Dr. Chris Palmer and research assistant Aaron MacDonald join Metabolic Mind to discuss one of the first published case series exploring metabolic and ketogenic interventions for OCD. In this video, you'll learn: - Why OCD deserves more attention as a serious, life-limiting condition - How three individuals saw dramatic symptom relief using a therapeutic ketogenic diet - What role ketosis may play in symptom reduction and why results varied from two weeks to a full year - The potential mechanisms behind metabolic therapies and brain energy metabolism - Why more research, including randomized controlled trials, is urgently needed This conversation is especially valuable for clinicians, patients, and families seeking new approaches for treatment-resistant OCD. It also touches on broader implications of metabolic health across a range of mental illnesses, including bipolar disorder and schizophrenia, and the importance of supervised, individualized treatment plans. Hear how both guests bring personal experience with OCD into their research, and why they're hopeful this work will pave the way for better, much-needed options in mental health care. Experts Featured:- Dr. Chris Palmer, MD Website - https://chrispalmermd.com - Book: https://brainenergy.com - Aaron John MacDonald, research assistant in the Metabolic and Mental Health Program at McLean Hospital Follow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry. Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.orgAbout us:Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them.Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.
Did you know that your body has its own unique weight loss blueprint and it might be the key to finally seeing results? In this episode, I explore the concept of obesity phenotypes and why one-size-fits-all approaches to weight loss often fail. I dive into the four main types I see in my practice: Hungry Brain, Emotional Hunger, Hungry Gut, and Slow Burn, and how understanding which one you align with can dramatically improve your treatment strategy. I also reflect on my own experiences, and those of my patients, emphasizing that it's not about willpower but biology and behavior. By identifying your phenotype, you can better tailor diets, medications, and lifestyle changes that work with your body instead of against it. Discover which obesity phenotype might be holding you back and learn how to finally tailor your weight loss journey for lasting success, tune in now! This website offers genetic testing for obesity phenotypes. https://www.phenomixsciences.com/ Episode Highlights: About obesity phenotypes and why weight loss isn't one-size-fits-all Overview of the four main obesity phenotypes: Hungry Brain, Emotional Hunger, Hungry Gut, and Slow Burn How GLP-1 receptor agonists help with appetite and satiety Behavioral strategies and mindfulness techniques for emotional eating Dietary tips for managing Hungry Gut and Slow Burn phenotypes Importance of personalized treatment plans for sustainable weight loss Real-life success story of phenotype-based weight loss Information about genetic testing through Phenomix Sciences Why seeking support from an obesity medicine specialist is important Connect with Dr. Alicia Shelly: Website | drshellymd.com Facebook | www.facebook.com/drshellymd Instagram | @drshellymd Linked In | www.linkedin.com/in/drshellymd Twitter | @drshellymd About Dr. Alicia Shelly Dr. Alicia Shelly was raised in Atlanta, GA. She received her Doctorate of Medicine from Case Western Reserve University School of Medicine in Cleveland, OH. Dr. Shelly has been practicing Primary Care and Obesity medicine since 2014. In 2017, she became a Diplomat of the American Board of Obesity Medicine. She is the lead physician at the Wellstar Medical Center Douglasville. She started a weekly podcast & Youtube channel entitled Back on Track: Achieving Healthy Weight loss, where she discusses how to get on track and stay on track with your weight loss journey. She has spoken for numerous local and national organizations, including the Obesity Medicine Association, and the Georgia Chapter of the American Society of Metabolic and Bariatric Surgeons. She has been featured on CNN, Fox 5 News, Bruce St. James Radio show, Upscale magazine, and Shape.com. She was named an honoree of the 2021 Atlanta Business Chronicle's 40 under 40 award. She also is a collaborating author for the, “Made for More: Physician Entrepreneurs who Live Life and Practice Medicine on their own terms''. Resources: FREE! Discover the 5 Reasons Your Weight-Loss Journey Has Gotten Derailed (And How To Get Back On Track!)
Justin Nault is a nutritional therapist who has helped thousands of clients escape our broken healthcare system and reclaim their health. We talked about his previous life as a professional musician and his own health journey, as well as the origins of allopathic medicine, seed oils and the hydroelectric dam analogy, what's wrong with rodent studies and nutrition research, how to eat for optimal energy, leanness and performance, longevity in sports, setting 90 years of goals, the politicization of health, finding self-love, and much more. You can learn more about Justin at justinnault.com/stevenMaui Nui Venison (The Healthiest Red Meat on the Planet)mauinuivenison.com/stevenNADS (Men's Organic Cotton Underwear)Use code STEVEN for 15% off NADSHeadspace (Meditation App)Try it for Free for 14 DaysSupport the Podcast Directlypatreon.com/somethingdiffpodWe are supported by these amazing BIG GIVERS:Michael Roy and Mark and Julie CalhounShow Notes: thenuggetclimbing.com/episodes/justin-naultNuggets:(00:00:00) – Intro(00:04:04) – Justin's life as a professional musician(00:08:10) – The costume(00:13:34) – Escapism(00:17:58) – Rocketman(00:20:18) – Collecting data from childhood(00:24:46) – Masochistic fitness(00:28:31) – Justin's niece(00:33:52) – The origins of allopathic medicine(00:35:23) – The limitations of nutrition science(00:37:20) – Seed oils(00:41:44) – The hydroelectric dam analogy(00:46:38) – PUFAs, Omega-6s, & Omega-3s(00:48:31) – Hyperphysiological doses, & fat loss(00:54:37) – A cheap way to check your metabolic rate(00:56:17) – What happened to Primal Kitchen(01:01:24) – Capitalism is demand-driven(01:05:28) – Whose funnel am I in?(01:08:44) – Justin's staple foods(01:10:59) – Cholesterol & thyroid health(01:19:21) – Carbs & saturated fat(01:24:20) – Calories, paleo, & metabolic rate(01:30:01) – Food is data(01:33:17) – Energy flux(01:38:06) – No more sugar cravings(01:41:17) – Architect of freedom(01:45:45) – Thyroid, carb sources, & dairy(01:49:11) – Fiber & blood glucose(01:50:16) – Sugar(01:57:07) – Fructose & fruit juice(01:59:24) – Rodent studies & nutrition research(02:04:41) – The illusion of authority(02:10:07) – The politicization of health(02:13:56) – Covid(02:21:56) – A journey of self-love(02:33:44) – Psychadelics & non-duality(02:37:46) – Is it working(02:45:07) – Top 5 daily prometabolic habits(02:48:49) – Equatorial living(02:51:33) – Leanness & performance(03:00:54) – Longevity in sports(03:03:16) – Justin's athletic life(03:05:32) – 90 years of goals(03:08:05) – Where to find Justin
Are you one of the millions of Americans who eat the Standard American Diet? Even if you're not, you're likely at risk of developing pre-diabeties, insulin resistance, and chronic inflammation. But, DON'T panic, because today's episode is packed with simple steps to help you take control of your blood sugar and lower your risk of diabetes and chronic disease.On this Salad with a Side of Fries episode, host Jenn Trepeck tackles the hard truth: many people are already pre-diabetic and don't even know it. From hidden insulin resistance to chronic inflammation, Jenn breaks down how the American diet and lifestyle are fueling a national health crisis. You'll learn how poor sleep, stress, a lack of fiber, and nutrient-depleted foods undermine your metabolic health—and what you can do today to take control and manage your risks. The Salad With a Side of Fries podcast is hosted by Jenn Trepeck, who discusses wellness and weight loss for real life, clearing up the myths, misinformation, bad science & marketing surrounding our nutrition knowledge and the food industry. Let's dive into wellness and weight loss for real life, including drinking, eating out, and skipping the grocery store.IN THIS EPISODE:(00:00) Why is the Standard American diet the recipe for pre-diabetes and diabetes, and what is insulin resistance(04:18) Metabolic health connects to every system, and the ultra-processed food dilemma(09:48) Why supplements are important(14:30) Everyone is pre-diabetic, unless. Nutrition: protein, fiber, quality fat(21:31) America's fiber problem and the role of the microbiome(26:55) Our society is sedentary(30:35) The impact stress and loneliness can have on your health(34:56) Are you sleep deprived(37:30) Let's talk about the environment and toxins(42:07) If you don't like it, don't eat it and focus on preventionKEY TAKEAWAYS:Most people eating the Standard American Diet are already pre-diabetic due to high consumption of ultra-processed foods, even if their labs don't reflect it yet. Modern farming, soil depletion, and long-distance transport have stripped our food of nutrients, making quality sourcing and supplementation essential.Staying ahead of metabolic disease means taking daily action—moving your body, managing stress, eating well, sleeping, and staying connected. Even a short walk after a meal can significantly reduce blood sugar spikes. Daily activity improves energy and focus, builds muscle, enhances insulin sensitivity, and monitors glucose levels.Just because a drink is labeled “prebiotic” doesn't mean it replaces real vegetables. Whole fruits and vegetables provide a variety of fibers that support gut health more effectively than most supplements or processed drinks. You can't supplement your way out of poor nutrition. Supplements are only as good as their quality. Many synthetic options don't break down or absorb adequately, making them useless. Food first, then smart supplementation.Chronic stress triggers hormonal changes that lead to insulin resistance and fat storage. The damage builds over time because most people don't recognize their stress. Managing stress is just as crucial as managing diet and exercise.QUOTES: (08:56) “Our food supply is ripening while in transit, not connected to the vine where nutrients come from.” - Jenn Trepeck(18:54) “Variety is your friend. Eat the rainbow.” - Jenn Trepeck(23:30) “I'm a big fan of supplements, but you cannot supplement your way out of poor nutrition. Food first, then mart supplementation.” - Jenn Trepeck(39:36) “Next time you need to replace a mattress or a pillow. Let's make sure it's a material that isn't going to off-gas toxins.” - Jenn Trepeck"It comes down to default vs design because the way our world is set-up around us, the default would easily be the recipe for pre-diabetes and diabetes. That's why we're here...unless you do this now." - Jenn TrepeckRESOURCES:Become A Member of Salad with a Side of FriesJenn's Free Menu PlanA Salad With a Side of FriesA Salad With A Side Of Fries MerchA Salad With a Side of Fries InstagramMovember: Men's HealthReal People, Real Results: Shannon Nutrition Nugget: Ultra-Processed FoodGMO, Organic, and Local, Oh My!How to Cheat8 Domains of HealthAmerica's Fiber ProblemQ & A: SupplementsTick…Tick…BOOM
Download the FREE Precision Fat Loss Guide to choose one of 6 strategies designed for your experience, goals, and lifestyle:witsandweights.com/free--What if shifting WHEN you eat could accelerate your fat loss results?Most of us tackle dieting by reducing calories evenly each day, but research suggests there may be a more effective approach (and it's easy and even fun to implement).Learn about a fascinating study that tested weekend refeeds against traditional daily restriction... with surprising results for muscle preservation and how your metabolism slows down during weight loss.You'll discover how restructuring your weekly calories could significantly impact body composition outcomes, despite creating the same total weekly calorie deficit.Maybe it is about calorie timing after all!Main Takeaways:Traditional daily calorie restriction works, but research suggests strategic timing may offer muscle-preservation advantagesThe "Weekend Diet" approach maintains the same weekly deficit while distributing calories differentlyTargeted carbohydrate increases on specific days could help minimize metabolic adaptationPractical implementation requires careful calculation of weekly weight loss targetsEpisode Resources:Download my FREE Precision Fat Loss GuideTry MacroFactor for free with code WITSANDWEIGHTSLink to 2020 study by Campbell et al.Previous episode: The #1 Reason to Eat More CarbsTimestamps:0:00 - Traditional dieting vs. the "weekend diet" (carb refeeds) 7:39 - Findings on fat-free mass preservation 9:23 - Metabolic impacts beyond muscle preservation 10:22 - Carbs, insulin, and muscle protein synthesis12:02 - Anabolic signaling pathways 13:03 - Glycogen replenishment (training hard on Monday!) 15:44 - Psychological factors 16:38 - How to implement the Weekend Diet 21:32 - Leptin, refeeds, and hormones Support the show
In this episode, host Ben Azadi and guest Catharine Arnston explore the critical role of mitochondria in metabolism and aging. Ben introduces his new book "Metabolic Freedom" and discusses the enzyme superoxide dismutase (SOD), which protects mitochondria from free radicals. Catherine highlights the benefits of algae, particularly spirulina and chlorella, in supporting mitochondrial health. They discuss algae's high SOD content, its role in combating inflammation, and its nutritional superiority. Catherine emphasizes the importance of consuming raw, high-quality algae to preserve its nutrients and shares her personal experiences and commitment to promoting algae for public health.
Think you need injections to lose fat and beat cravings? Think again. In this episode, Ben Azadi shares a powerful, drug-free 7-day protocol to reset your metabolism, reduce cravings, and fire up fat burning—naturally. Purchase Metabolic Freedom here: https://bit.ly/4dv6mll If you go to your local Barnes & Noble bookstore, and purchase Metabolic Freedom in store today. I will give you the following gifts.... 1. A 60 minute question & answer Zoom video session with me in a small group setting!! ($5,000 retail value) 2. A free course on the metabolism ($997 retail value) 3. Exclusive interview series with Dr Jason Fung, Megan Ramos, Cynthia Thurlow & Dr Daniel Pompa ($497 retail value) 4. Full access to my Burn Fat Challenge recordings with detailed notes and presentation slides ($997 retail value) 5. Seed oil allergy card to use at restaurants $7,491 Retail Value (FREE FOR YOU!) Once you've purchased the book at your local Barnes & Noble, email support@ketokamp.com with a photo of your receipt, and we'll grant you full access to all of these goodies!! You'll learn: Why most Ozempic users gain the weight back The 3 foods sabotaging your metabolism How to eat, fast, and fuel your body for real results The exact 7-day reset plan to feel unstoppable How to access $7,000 in bonuses when you grab Metabolic Freedom at Barnes & Noble