Podcasts about metabolic

On this episode of Vitality Radio, Jared breaks down the probiotic strains he trusts most and explains why not all probiotics deserve the same reputation. Learn the differences between spore-based probiotics, traditional human strains, postbiotics, and beneficial yeast, and discover how each supports digestive health, immune function, metabolism, mental health, gut barrier integrity, and overall wellness. Jared highlights the research behind favorite strains like Bacillus coagulans, Bacillus subtilis, Bacillus clausii, Lactobacillus reuteri, Akkermansia muciniphila, and Saccharomyces boulardii, while also explaining how he selected the ingredients used in Vital Spores, Back on Tract, and GLP-1 Metabolic Optimizer. Whether you're new to probiotics or looking to better understand the science behind today's most popular strains, this episode offers practical guidance to help you make more informed supplement decisions.Products:Back On TractPrecision Probiotic Vital SporesGLP-1 Metabolic OptimizerAdditional Information:448: VR Vintage: The Great Debate in Probiotics: Human Strains vs. Spores 627: GLP-1 Explained Part 1: How to Support Metabolism Without Drugs628: GLP-1 Explained Part 2: The Lifestyle Blueprint for Real Metabolic: OptimizationVisit the podcast website here: VitalityRadio.comYou can follow @vitalitynutritionbountiful and @vitalityradio on Instagram, or Vitality Radio and Vitality Nutrition on Facebook. Join us also in the Vitality Radio Podcast Listener Community on Facebook. Shop the products that Jared mentions at vitalitynutrition.com. Let us know your thoughts about this episode using the hashtag #vitalityradio and please rate and review us on Apple Podcasts. Thank you!Just a reminder that this podcast is for educational purposes only. The FDA has not evaluated the podcast. The information is not intended to diagnose, treat, cure, or prevent any disease. The advice given is not intended to replace the advice of your medical professional.This podcast is produced by DrTalks.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://drtalks.com/podcast-service/⁠

In this fascinating deep dive, Dr. Scott Watier and Tommy Welling break down a landmark study from Nature Metabolism that tracked what happens inside the body during a seven-day water fast — and the findings go far beyond weight loss. The hosts walk through the three distinct phases of an extended fast, explaining how the first 48 hours switches the body into fat-burning mode, day three triggers a dramatic biological renovation involving immune function, brain health, and cardiovascular protection, and days five through seven begin locking in longer-lasting metabolic changes. One of the most reassuring takeaways is around lean muscle loss — the hosts explain why the apparent muscle decrease during a longer fast is largely water and glycogen, not actual tissue, and how fat loss from the fast is what actually stays off. They also address how everyday fasters can capture some of these deeper benefits through consistent fasting windows, strategic low-carb nutrition opportunities, and proper electrolyte support without needing to do a week-long fast. The episode closes with practical guidance on how to break an extended fast gently — starting with easy proteins and healthy fats — and a challenge to pull out the calendar and schedule your next longer reset before the week is out. ⁠⁠⁠Take the NEW FASTING PERSONA QUIZ! - The Key to Unlocking Sustainable Weight Loss With Fasting!⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Resources and Downloads: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠SIGN UP FOR THE DROP OF THE ULTIMATE GUIDE TO BLOOD SUGAR CONTROL⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠GRAB THE OPTIMAL RANGES FOR LAB WORK HERE! - NEW RESOURCE! ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠FREE RESOURCE - DOWNLOAD THE NEW BLUEPRINT TO FASTING FOR FAT LOSS!⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠SLEEP GUIDE DIRECT DOWNLOAD⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠DOWNLOAD THE FASTING TRANSFORMATION JOURNAL HERE!⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Partner Links: Get your⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ FREE BOX OF LMNT⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ hydration support for the perfect electrolyte balance for your fasting lifestyle with your first purchase⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ here!⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Get ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠25% off a Keto-Mojo⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ blood glucose and ketone monitor (discount shown at checkout)! ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Click here!⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Our Community: Let's continue the conversation. Click the link below to JOIN the ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Fasting For Life Community⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠, a group of like-minded, new, and experienced fasters! The first two rules of fasting need not apply! If you enjoy the podcast, please tap the stars below and consider leaving a short review on Apple Podcasts/iTunes. It takes less than 60 seconds, and it helps bring you the best original content each week. We also enjoy reading them! Article Link: https://staycuriousmetabolism.substack.com/p/what-happens-to-your-body-during?publication_id=2682303&post_id=201125972&r=wn02o&triedRedirect=true

Insulin resistance — not willpower — is why you can eat 1,200 calories, train, and still not lose weight. Metabolic-health author Ben Azadi joins Liz Roman to explain sugar burning vs. fat adaptation, how to do keto without a gallbladder, why seed oils sabotage "keto" diets, and the reframe that changes everything: you get healthy to lose weight, not the other way around. Real root-cause answers for women who've been told their labs are "normal." Connect with Ben: Instagram | Web | Youtube Get Ben's New Book - Keto Flex *** CONNECT:

Metabolic flexibility expert Ben Azadi joins me to explain why cortisol, not diet alone, drives stubborn belly fat in midlife women. WHAT YOU'LL LEARN Why cortisol, not just diet, is the real driver of stubborn belly and visceral fat in women over 35 What role carbohydrates actually play in lowering cortisol load and supporting recovery Why the three hours before bed matter more for fat loss than your workout window How to time fasted workouts around your menstrual cycle for the best hormonal response Why sleep, steps and sunlight need to come before any diet or fasting protocol How increasing protein and building muscle mass changes your insulin sensitivity What's really causing your bloating, and why it may have nothing to do with your gut TIMESTAMPS 00:00 Metabolic Flexibility, Cortisol Belly Fat And The Overnight Fat-Burning Sleep Window 10:08 Fasted Training By Menstrual Cycle, Sleep Foundations And Building Muscle For Insulin Sensitivity 20:55 Why Stress Causes Bloating Plus Ben's Top Biohacks: Sauna, Red Light Therapy And Lymphatic Flow 27:00 Ben Azadi's Ketoflex Revised Book And Where To Connect With Him VALUABLE RESOURCES Ketoflex Revised (Ben's new book)  https://ketoflexbook.com/ Ben Azadi's website https://benazadi.com/ Follow Ben on Instagram https://www.instagram.com/thebenazadi/ Timeline - Support your mitochondrial health: Timeline Mitopure delivers Urolithin A at the clinically studied dose to support cellular renewal and energy production, helping counter the natural decline in mitochondrial function that comes with age.

"Doc, do I need to take this forever?" It's one of the most common questions I hear in my office, whether it's someone's very first visit or someone who's already lost 30, 40, even 80 pounds and is feeling great. In this episode, I break down why your body fights so hard to regain weight after you lose it, and why that's biology, not failure. I walk through the new ATTAIN Maintain trial, a study of 376 adults who had already lost significant weight on tirzepatide or semaglutide, testing whether switching to an easier once-daily oral GLP-1 could help them keep the weight off, instead of just asking whether stopping medication causes regain. Maintenance isn't about staying on one medication forever. It's about having an individualized, active plan, and the ATTAIN Maintain data gives us more options than ever to build one. Episode Highlights: Why your metabolism and hunger hormones fight to reverse weight loss Lessons from the SURMOUNT-4 trial on what happens when treatment stops completely Inside the ATTAIN Maintain trial design and who was studied The weight maintenance results: oral medication vs. placebo Why maintenance therapy doesn't have to look like the treatment that got you there What actually goes into a sustainable long-term plan beyond medication Connect with Dr. Alicia Shelly: Website | drshellymd.com Facebook | www.facebook.com/drshellymd Instagram | @drshellymd Linked In | www.linkedin.com/in/drshellymd Twitter | @drshellymd About Dr. Alicia Shelly Dr. Alicia Shelly was raised in Atlanta, GA. She received her Doctorate of Medicine from Case Western Reserve University School of Medicine in Cleveland, OH.  Dr. Shelly has been practicing Primary Care and Obesity medicine since 2014.  In 2017, she became a Diplomat of the American Board of Obesity Medicine. She is the lead physician at the Wellstar Medical Center Douglasville. She started a weekly podcast & Youtube channel entitled Back on Track: Achieving Healthy Weight loss,  where she discusses how to get on track and stay on track with your weight loss journey. She has spoken for numerous local and national organizations, including the Obesity Medicine Association, and the Georgia Chapter of the American Society of Metabolic and Bariatric Surgeons. She has been featured on CNN, Fox 5 News, Bruce St. James Radio show, Upscale magazine, and Shape.com. She was named an honoree of the 2021 Atlanta Business Chronicle's 40 under 40 award. She also is a collaborating author for the, "Made for More: Physician Entrepreneurs who Live Life and Practice Medicine on their own terms''.   Resources: FREE! Discover the 5 Reasons Your Weight-Loss Journey Has Gotten Derailed (And How To Get Back On Track!)

What if your metabolism isn't broken—but responding to the signals it receives? In this episode, Debbie Potts explores how PNOĒ breath analysis can reveal more than calories or fat-burning zones. Discover the five PNOĒ Metabolic Patterns™ and how stress, under-fueling, muscle loss, hormones, blood sugar, digestion, sleep, and recovery can influence how your body produces and uses energy. You'll learn why the same fasting, diet, or exercise strategy may help one person but make another feel worse—and why identifying your metabolic pattern and the correct order of operations matters. Learn more and schedule PNOĒ metabolic testing: www.debbiepotts.net YouTube @coachdebbiepotts Coach Debbie Potts Instagram @coachdebbiepotts Restore communication. Build resilience. Create your FutureYou. This podcast is for educational purposes only and is not intended to diagnose or treat any medical condition.

Mike Brown and Jesse Carroll from Hamilton Medical break down ventilatory management for the DKA patient and other metabolic-acidosis presentations in the prehospital setting. They focus on why minute ventilation, not just rate, matters when you take a patient's airway: match or exceed the patient's compensatory minute volume, size tidal volume to ideal body weight), and account for dead space. Practical demos cover when to favor a mechanical ventilator over BVM, using NIV-ST to support fatigued spontaneous breathers, and how to set tidal volume and rate to replace 17–20 L/min minute volumes seen in severe hyperventilation. They also unpack the ICEBERG Study and the concept of driving pressure, why driving pressure may better reflect lung stress than plateau pressure alone, and why higher driving pressures are associated with worse outcomes. The discussion reviews current evidence supporting efforts to keep driving pressure low when clinically feasible.

It was an absolute pleasure to have Drs David and Jen Unwin on the show! Watch them dissect through Diabetes, Metabolic diseases, low carb, food addiction and much more! Dr. David Unwin is an award-winning general practitioner (or family doctor) known for pioneering the low-carb approach in the UK. Through the years, Dr. Unwin has been highly recognized for his work within his field.In 2015, Dr. Unwin was made a UK Royal College of General Practitioners expert clinical advisor in 2015 for his dedicated efforts within the areas of patient communication and type 2 diabetes. Dr. Unwin's work has been covered by BBC, New Scientist, Daily Mail,  and The British Medical Journal. he also plays a major role in the charity - The Public Health Collaboration. Dr. Jen Unwin is a consultant clinical health psychologist based in the United Kingdom. She works with the NHS helping patients manage chronic illness and achieve wellbeing. She also works with her GP husband Dr. David Unwin helping patients stick to lifestyle changes. She has focussed a lot of her time into food and carbohydrate addiction. She is also the author of the book - Fork in the Road: A Hopeful guide to Food Freedom which can be bought from Amazon globally.Check out the PHC website - https://phcuk.orgYou can download David's infographics from - https://phcuk.org/resources/#infographicsThe Unwins also host an online conference aimed at improving the food choices of youths - https://www.the-chc.org/fas/ifacc-2026The Unwins, Phil, Rishard, Zsofia, Anthony, myself and many more will be at the Carnivore Spain conference in November 2026. Grab your tickets on the website - https://carnivorespain.comFollow David on X - @lowcarbGPFollow Jen on X - @drjenunwin

Scientific Sense ® by Gill Eapen: Prof Mike Snyder leads the center for genomics at Stanford. He collects and analyzes deep data from wearables to transform helathcare through analysis and behavior modifications.Please subscribe to this channel:https://www.youtube.com/c/ScientificSense?sub_confirmation=1

One of the most significant changes in women's health has officially arrived. Polycystic Ovary Syndrome (PCOS) is now known as Polyendocrine Metabolic Ovarian Syndrome (PMOS)—a name that better reflects the true nature of this common condition. In this episode, I sit down with Cory Ruth, RDN, women's health and PMOS expert, to discuss why this historic name change was made and what it means for the millions of women living with the condition. We explore how the previous name often led to confusion by focusing on the ovaries, when the condition is fundamentally driven by complex endocrine and metabolic dysfunction. Cory explains why insulin resistance plays such a central role, why weight loss can feel so frustrating, how PMOS impacts fertility and long-term health, and what women can do to support their metabolism through nutrition and lifestyle. If you've ever struggled with stubborn weight, blood sugar instability, irregular cycles, infertility, or have been diagnosed with PMOS (formerly PCOS), this conversation will help you better understand what's happening inside your body—and why this new name represents an important step forward in women's healthcare. WHAT WE DISCUSSED: Why PCOS was officially renamed Polyendocrine Metabolic Ovarian Syndrome (PMOS) How insulin resistance drives many PMOS symptoms Why PMOS is much more than an ovarian condition The connection between metabolism, hormones, fertility, and overall health Why weight loss is often so challenging with PMOS Nutrition and lifestyle strategies to improve metabolic health Common myths surrounding PMOS Practical first steps women can take to better manage the condition FOR MORE FROM CORY RUTH, RDN: Website: www.thewomensdietitian.com Instagram: @thewomensdietitian Book: PCOS Is My Power LET'S CONNECT: Instagram: @shana.hussin.rdn Facebook: Fast To Heal With Shana Hussin Website: shanahussinwellness.com ⭐ 90-Day Metabolic Reset (Start Here!) If you're struggling with insulin resistance, weight loss resistance, blood sugar issues, or have been diagnosed with PMOS (formerly PCOS), the 90-Day Metabolic Reset is the perfect place to begin. This comprehensive program will help you restore metabolic health through simple, science-backed nutrition and lifestyle strategies designed to address the root causes of metabolic dysfunction.

What can 21 days of continuous glucose and ketone data, recorded during a 1,000-mile cycling journey, reveal about managing type 1 diabetes on a ketogenic diet?Dr. Ian Lake is a UK-based primary care physician who has lived with type 1 diabetes for more than 30 years. After two decades of conventional high-carbohydrate management, he adopted a very low-carbohydrate, ketogenic approach and began examining insulin not simply as a glucose-lowering medication, but as a metabolic hormone whose requirements are influenced by nutrition, exercise, sleep, circadian rhythm, hydration, and stress. His new book, Shifting Gears, documents the ride and the lessons he took from it.Dr. Lake treated the journey as a 21-day personal experiment, wearing continuous glucose and ketone monitors while consuming roughly 20 grams of carbohydrate per day. In this conversation with Dr. Dominic D'Agostino, he shares what his data showed: an average ketone level near 1.2 mmol/L, daily insulin requirements declining from the mid-20s of units to around 16, and an episode in which glucose and ketones rose together after he had taken too little insulin.Dr. Lake describes how, in his case, one unit of insulin brought his ketones from approximately 3.0 to 0.9 mmol/L within about 20 minutes. He and Dr. D'Agostino use the experience to explore the distinction between nutritional ketosis and diabetic ketoacidosis, the essential role of adequate insulin, and why ketone readings must always be interpreted alongside glucose levels and clinical context.They also discuss insulin sensitivity during prolonged exercise, the practical challenges of adjusting insulin during endurance activity, and research suggesting that fat-adapted athletes may sustain high rates of fat oxidation at relatively high exercise intensities.Questions Answered in This EpisodeWhat did 21 days of continuous glucose and ketone monitoring reveal during a ketogenic, 1,000-mile cycling journey?How did prolonged endurance exercise affect Dr. Lake's daily insulin requirements?How is nutritional ketosis different from diabetic ketoacidosis, and what role does insufficient insulin play in DKA risk?What did Dr. Lake observe when his glucose and ketones began rising at the same time?How might fat adaptation influence fuel use and endurance performance?What are the practical limitations of continuous glucose and ketone monitoring for real-time insulin decisions?This conversation offers a rare look at 21 consecutive days of glucose, ketone, insulin, nutrition, and exercise data, while also emphasizing that Dr. Lake's experience is an individual case, not a substitute for personalized medical supervision.More Links:Shifting Gears, Dr. Lake's book, on AmazonType1Keto, Dr. Lake's site featuring the book and the Zero Five 100 projectSpecial thanks to the sponsors of this episode:✅ Zocdoc: Find and instantly book a top-rated doctor here.✅ fatty15: Get an additional 50% off a 90-day subscription starter kit with code METABOLICLINK.✅ Toups and Co: Get 25% off your first order with code METABOLIC.In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel!Find us on social: InstagramFacebookYouTubeLinkedInPlease keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.

Kate and Guy are back from Roth. We hear their feedback from the event and Kate tells us how her marathon went! We review the racing from the WTCS Hamburg and Hayden Wilde's personal challenges getting over sickness plus Cassandre Beaugrand's race at the Diamond League and her record-breaking achievements. The IRONMAN 70.3 in Swansea finished early for Mika Noodt after a bike crash. We chat about safety concerns on race courses. After Danielle Lewis's announcement of her REDS diagnosis we delve into the critical role of nutrition in athletic performance. The conversation highlights the need for coaches to be vigilant about their athletes' nutritional habits and the potential consequences of underfuelling. Additionally, we explore the different types of body composition and the significance of metabolic efficiency in endurance sports. TIMESTAMPS: 0:00:00 – Kate and Guy are back from Roth 0:04:48 – Kate's marathon 0:05:53 – Cassandre Beaugrand and Alex Yee at the Diamond League 0:08:55 – WTCS Hamburg 0:11:56 – Hayden Wilde 0:20:29 – WTCS Women's Race 0:21:11 – Lisa Tertsch's racing making her unpopular? 0:31:36 – IM703 Swansea safety concerns 0:33:23 – The worst run of Jack's career 0:38:10 – Mika Noodt's bike crash 0:40:24 – This weekend IRONMAN Lake Placid 0:43:19 – Danielle Lewis announces she has REDS 0:44:27 – The hosts experiences of underfuelling in athletes 0:51:16 – Jack goes to the chiropractor 0:52:49 – Nutrition and underfuelling 0:59:37 – Metabolic efficiency and testing LINKS: Jack Moody at https://www.instagram.com/jacktmoody/ Kate Bevilaqua at https://www.instagram.com/katebevilaqua/ Guy Crawford at https://www.instagram.com/guyrcrawford/ Challenge Roth at https://www.challenge-roth.com/en/ WTCS Hamburg - https://events.triathlon.org/2026-wtcs-hamburg IRONMAN 70.3 Swansea at https://www.ironman.com/races/im703-swansea Danielle Lewis https://www.instagram.com/danilewistri/ Mika Noodt https://www.instagram.com/mika.noodt/ Cassandre Beaugrand https://www.instagram.com/cassandrebeaugrand/

What if addiction isn't a moral failure — and it isn't just a brain disease either? What if it's the natural expression of a terrain that never got the support it needed?In this episode of I Love Being Sober, Tim Westbrook sits down with Dr. Nasha Winters — naturopathic oncologist, bestselling author, and 35-year stage IV ovarian cancer thriver — for one of the most clinically rich and emotionally honest conversations this podcast has ever hosted. Recorded live at Camelback Recovery's outpatient treatment center in Scottsdale, Arizona, in front of a live audience of clients and staff.Dr. Winters scored a perfect 10 out of 10 on the ACE (Adverse Childhood Experiences) scale. She came from a family shaped by alcoholism, addiction, mental illness, and trauma. She was days from death when she was diagnosed with terminal cancer at 19 — and she was sent home to die. Instead, she spent the next three decades building one of the most comprehensive frameworks in integrative medicine: the Terrain Ten.This conversation bridges two worlds that rarely talk to each other: terrain-based medicine and addiction recovery. And the overlap is exact.In this episode, you'll learn:Why sugar and ultra-processed food activate the same dopamine receptors as cocaine and heroin — and how that keeps recovery stuckHow unstable blood sugar mimics and worsens the craving cycle in early sobrietyWhy Dr. Winters now puts mental and emotional health FIRST in her Terrain Ten — flipping the framework she published in 2017The ACE score, what it predicts, and why a score of 3 or above dramatically increases disease riskWhat intermittent fasting actually does to the brain in recovery — and how to start without white-knuckling itThe emerging field of metabolic psychiatry and why ketosis has reversed bipolar disorder, schizophrenia, and addiction in clinical trialsWhy being “never sick” is a red flag, not a health flexHow chronic stress puts the body in a state where treatments “bounce off” — and what to do about itEMDR, ibogaine, and psychedelic-assisted therapy in the context of trauma and addiction recoveryThe two things that showed up as universal common denominators across 500 cancer and mental health patients: not feeling seen, and not feeling heardThe audience Q&A goes even deeper — covering sleep and metabolic health, keto and depression, sexual abuse and trauma processing, and what it takes to rebuild a life after violence and addiction.This is not a light episode. It's a complete one.Resources mentioned:Website: Dr. Nasha Winters | Tend the TerrainYouTube & Podcast: Tend the Terrain Podcast with Dr. NashaInstagram: Instagram.com/drnashawintersSubstack: Tending the Terrain: Reflections by DrNasha(TM)Facebook: Facebook.com/drnashaincBook: The Metabolic Approach to CancerBook: Change Your Diet, Change Your Mind — Dr. Georgia EdeBook: Brain Energy — Dr. Chris PalmerBook: The Circadian Code — Dr. Satchin PandaCamelback Recovery outpatient treatment: CamelbackRecovery.com#AddictionRecovery #SoberLiving #MetabolicHealth #TraumaHealing #MentalHealth #DualDiagnosis #SubstanceUseDisorder #ILoveBeingSober #CamelbackRecovery #Scottsdale #Phoenix #TerrainTen #DrNashaWinters #BloodSugar #DopamineRecovery #IntermittentFasting #MetabolicPsychiatry #ACEScore #SoberLifeGo to camelbackrecovery.com for more information

Hosts: Ed Jones (Owner – Nutrition World) & Clint Powell A variety of topics all related to living a healthy life Presented by: Nutrition World www.nutritionw.com Broadcasting from the Nooga Dentistry Studio www.noogadentistry.com Production of: Whitfield Media Group www.vitalhealthradio.com Title: All about Spike Proteins with Dr. Glenn, Beyond Cholesterol & Better Heart Testing with Dr. Dearing [0:00:00] – Intro: Brian Johnson, Longevity & Oxalates + Farmers Market Light banter about: Ed coining the term “peak span” and using it in interviews. Ed's social media success (8.3 million views in 90 days). Joking about Ed doing a shirtless video and his bodybuilding competition and carb loading. Ed talks about Brian Johnson (longevity guru who spends ~$2M/year trying to live to 120): Johnson recently announced an autoimmune condition where his stomach is “eating its own stomach.” Ed admires his data and “Blueprint” protocol but believes two key factors in Johnson's regimen contributed to this issue. Ed teases that one factor is excess oxalate-rich foods; the other factor is left as a teaser for Ed's social media video. Ed announces a weekly farmers market at Nutrition World: Every Wednesday, inside the store, morning to mid-afternoon. Run by a young family with clean farming practices and minimal chemicals. Nutrition World does not profit from it; framed as a service to the community and support for small farmers. [0:05:04] – Upcoming Guests, Ed's E‑Books & Podcasts Ed previews two interviews for this episode: Dr. Glenn – testing and managing spike proteins. Dr. Curt Dearing – discussing his new book “Beyond Cholesterol” and non-traditional views on cardiovascular risk. Ed's e‑books: Six e‑books available on theholisticnavigator.com, including: Quality sleep Oxalates and pain “Are You Sick and Tired?” (diet & overall health) Oral health Immune system “Core Four” foundational supplements Podcasts: Ed mentions his Holistic Navigator podcast Clint promotes Nooga Podcasts (noogapodcasts.com) – a network of 20+ podcasts. [0:09:26] – Interview with Dr. Glenn: What Are Spike Proteins & Why They Matter Dr. Glenn defines spike proteins: Discovered in the 1960s, normally part of viruses from nature. Our immune system usually recognizes and dissolves natural spike proteins. For COVID-era, lab-made spike proteins: They are not recognized properly by the body. They can persist and are not efficiently eliminated. Mechanism (simplified): Spike proteins interact with ACE2 receptors (“locks” on the cell door). They unlock and open the cell doors, enter the cells, and damage/destroy cells from the inside. Clint notes he never heard the term “spike protein” before COVID; Dr. Glenn explains: Previously, they weren't an issue because the body just handled them. This is the first time in history we've dealt with lab-made spike proteins at scale. Dr. Glenn stresses this is not simply vaccinated vs. unvaccinated: mRNA vaccines were designed to produce spike proteins. But unvaccinated people with bad cases of COVID can also carry very high spike levels. His personal story: Got severe COVID in Jan 2020, pre-official naming: 2 weeks very ill on couch/bed. 3 months to feel “recovered,” but that was just the start of long-term issues. Over the next 3+ years, progressive cellular damage accumulated, leading to a broad set of symptoms. Dr. Glenn's symptoms when spikes were very high: Whites of eyes turned gray, with burning eyes all day (constant eye drops). Tinnitus (ringing in ears). Cyclical rashes under armpits. Burning nerves in quads; needed leg massage devices nightly to sleep. Gout attacks (kidneys not handling uric acid well). Venous congestion in lower left leg. Severe fatigue, getting sick frequently despite doing everything “right.” Developed endocarditis (inflammation of heart and valves); resting heart rate jumped from 55–60 to 80–105. Subtle Bell's palsy–type weakness on left side of face and brain symptoms. Laboratory findings: Test: SARS‑CoV‑2 spike protein antibody test (semi-quantitative). Thresholds: 1000: likely too high, potential cell damage. 5000: “a whole other level of danger.” His highest result: 11,694 (measured around Oct 28, 2023). Progress over four tests: 11,694 → 11,087 → ~9,950 → 8,905 (as of June 30, current year). Many symptoms have significantly improved, though: Heart rate better but not back to baseline. Tinnitus persists. Spike level is still high, so work remains. Symptoms can vary dramatically from person to person: Because spikes can enter different “doors” (cells/tissues) in different bodies. One person's profile may be mostly neurological; another's cardiovascular, etc. Dr. Glenn's clinic policy: He will not work with someone on issues like hormones, gut, or cognitive problems without a spike antibody test, because: Otherwise they may be “paddling upstream” against ongoing spike-related damage. Observation: Many patients say: “My doctor says my bloodwork is fine,” yet they feel terrible. Conventional doctors rarely order spike protein antibody tests [0:23:01] – Managing High Spike Proteins: Testing, Risk & Protocol Who Should Test & How: Ed notes frequent COVID infections (he's had it six times) and that many people have unexplained symptoms. Both Ed and Dr. Glenn suggest: Spike antibody testing should be considered for anyone with mysterious chronic symptoms, regardless of age or vaccination status. Testing can be done through labs like Be Well Labs (which Nutrition World works with) or other local options. Reference values: < 0.08 means essentially no exposure to COVID. Out of ~130 tests Dr. Glenn has reviewed, only one person was

The provided transcript highlights the five essential and specialized roles the liver plays in maintaining human health. This organ acts as a selfless metabolic hub by regulating blood sugar levels through processes like glycogenolysis and gluconeogenesis to fuel the brain and red blood cells. It also serves as the body's primary center for cholesterol production, providing the necessary materials for hormone synthesis and cell membrane integrity. Furthermore, the liver is the exclusive producer of ketone bodies, which offer an alternative fuel source for other tissues during periods of fasting. Beyond energy management, the liver is responsible for detoxifying the body by converting toxic ammonia into urea for safe excretion. Finally, it utilizes a specific oxygenase system to neutralize organic molecules, ensuring that potentially harmful substances are made water-soluble and filtered out by the kidneys.

If you've seen headlines linking Ozempic and other GLP-1 medications to sudden eye strokes, I want to stop the panic right here.  In this episode, I break down what the research on NAION actually shows, who's really at risk, and why the scary relative-risk numbers you're seeing online don't tell the whole story. I walk you through what NAION is, why patients on semaglutide often already carry the underlying risk factors that get left out of the clickbait, and what the difference is between an observational study raising a signal and a randomized trial proving cause and effect. I also share the warning signs that mean you should go to the ER immediately, not wait for your next appointment. You'll walk away knowing exactly how to think about this headline, what questions to bring to your own doctor, and why staying on your medication is usually the right call. Episode Highlights: What NAION is and how it affects the optic nerve The risk factors patients on GLP-1s often already have What the 37-million-person study actually found — and didn't Why randomized trials tell a different story than observational data Absolute risk vs. relative risk, explained simply Warning signs that mean go to the ER now Why sleep apnea complicates the whole picture Connect with Dr. Alicia Shelly: Website | drshellymd.com Facebook | www.facebook.com/drshellymd Instagram | @drshellymd Linked In | www.linkedin.com/in/drshellymd Twitter | @drshellymd About Dr. Alicia Shelly Dr. Alicia Shelly was raised in Atlanta, GA. She received her Doctorate of Medicine from Case Western Reserve University School of Medicine in Cleveland, OH.  Dr. Shelly has been practicing Primary Care and Obesity medicine since 2014.  In 2017, she became a Diplomat of the American Board of Obesity Medicine. She is the lead physician at the Wellstar Medical Center Douglasville. She started a weekly podcast & Youtube channel entitled Back on Track: Achieving Healthy Weight loss,  where she discusses how to get on track and stay on track with your weight loss journey. She has spoken for numerous local and national organizations, including the Obesity Medicine Association, and the Georgia Chapter of the American Society of Metabolic and Bariatric Surgeons. She has been featured on CNN, Fox 5 News, Bruce St. James Radio show, Upscale magazine, and Shape.com. She was named an honoree of the 2021 Atlanta Business Chronicle's 40 under 40 award. She also is a collaborating author for the, "Made for More: Physician Entrepreneurs who Live Life and Practice Medicine on their own terms''.   Resources: FREE! Discover the 5 Reasons Your Weight-Loss Journey Has Gotten Derailed (And How To Get Back On Track!)

Metabolic health may be the foundation of a healthy brain, and a growing community of researchers, clinicians, and educators is working to bring that message into mainstream medicine.In this interview, Dr. Bret Scher talks with Dr. Dom D'Agostino at the Citizen Science Initiative (CoSci) conference to discuss everything from the recent screening of The Cholesterol Code documentary to the rise of N-of-1 research, the future of metabolic psychiatry, and the urgent need for nutrition education in medical schools.In this conversation, you'll learn:Dr. D'Agostino's reaction to The Cholesterol Code documentary and what stood out mostHow N-of-1 citizen science is reshaping the way we think about metabolic healthWhy metabolic health may be a stronger predictor of cardiovascular outcomes than LDL aloneHow nutrition education made its way into the USF College of Medicine curriculumWhat the latest research is revealing about ketogenic metabolic therapy and cancer, brain health, and immune functionWhy metabolic psychiatry is one of the most exciting emerging fields in medicineHow exogenous ketones and ketogenic diets fit into clinical practice and ongoing researchThis discussion offers a thoughtful look at where metabolic medicine is headed and why prioritizing whole-body health is becoming central to supporting the brain.

In this episode of Girl Talk with Tay, I sit down with Bracha Banayan, family nurse practitioner, entrepreneur, and founder of IVDrips and Hello Dose, for one of our most fascinating conversations yet. We dive into the science behind GLP-1 medications, why they're about so much more than weight loss, and how they're changing the conversation around longevity, metabolic health, and healthy aging.Bracha explains how GLP-1s work in the body, why weight gain is often rooted in biology rather than willpower, and how factors like glucose, insulin, inflammation, and hormones all play a role in long-term health. We also discuss who may benefit from GLP-1 medications, including women navigating perimenopause and menopause, adults focused on cardiovascular health, and those looking to improve metabolic wellness.We also get into fertility, blood sugar, continuous glucose monitors, and the surprising ways GLP-1s may help reduce cravings by working on the brain's reward system. Beyond medications, Bracha shares the foundational habits she believes everyone should prioritize first from walking after meals and getting morning sunlight to improving sleep and building sustainable wellness routines.Whether you're curious about GLP-1s, trying to better understand metabolic health, or looking for practical ways to optimize your health for the long run, this episode is packed with insights and actionable takeaways.xo, Tay⸻Follow Bracha Banayan!

New evidence from the first-ever RCT shows ketogenic therapy can rapidly improve metabolic health in schizophrenia-spectrum and bipolar I disorders, and shows early signals of psychiatric improvement.In this video, Dr. Bret Scher breaks down this newly published study led by Dr. Judith Ford at UCSF: the first randomized controlled trial with peer-reviewed results investigating ketogenic therapy in people with schizophrenia-spectrum disorders and bipolar-1 disorder with psychotic features.You'll learn:How the study was designed (a 1-month randomized phase plus an optional 3-4 month single-arm extension)What happened in the first 30 days (clear improvements in metabolic markers; psychiatric outcomes showed trends that did not reach statistical significance in the randomized portion)What improved over longer follow-up in the extension phase (encouraging changes in metabolic health, cognition, and psychiatric measures)Why this matters for patients and families today, and what future, longer controlled trials need to confirmPublished in Schizophrenia Bulletin and funded by the NIMH and Baszucki Group, this study adds to the growing literature on the potential benefit of ketogenic therapy for psychiatric disorders.These results indicate the need for larger, extended randomized controlled trials to test the safety and efficacy of ketogenic therapy in patients living with serious mental illness.

The Midlife Metabolic Shift: Why Menopause Changes Your Weight, Cholesterol, and Heart HealthMost conversations about menopause focus on hot flashes, hormone therapy, and symptom relief.But there's another important transition happening beneath the surface—one that affects your metabolism, cholesterol, insulin sensitivity, body composition, and long-term cardiovascular health.In this episode of Midlife Revival, Dr. Taniqua Miller explores what she calls the midlife metabolic shift and explains why so many women begin noticing weight gain, poor sleep, rising cholesterol levels, and changes in blood sugar—even when they're doing everything "right."You'll learn why perimenopause is more than a reproductive transition. It's also a cardiometabolic transition that deserves attention long before lab values become abnormal.In This Episode: Why cardiovascular disease remains the leading cause of death among women  The connection between estrogen decline and cardiometabolic health  How estradiol, insulin, and cortisol interact during perimenopause  Why belly fat tends to increase during midlife  What rising cholesterol and blood sugar may be telling you  Why "normal" lab results don't always tell the whole story  The role of sleep, stress, and nervous system regulation in metabolic health  Why strength training and nutrition become even more important in midlife  How to think differently about prevention during the menopause transition Key TakeawayIf you've been told that your labs are "normal" but you know something feels different in your body, you're not imagining it.Perimenopause isn't simply about managing symptoms. It's a critical window for understanding and protecting your future cardiometabolic health.Coming Up NextThis episode kicks off a new series on cardiometabolic health in midlife. Stay tuned for upcoming conversations on: Nutrition for the menopausal transition  Protein and muscle health  Strength training after 40  Sleep and metabolic health  Hormone therapy and cardiovascular risk  Practical strategies to support long-term health and longevity Connect with Revival Women's HealthIf you're looking for a more comprehensive approach to midlife health—one that addresses hormones, cardiovascular health, metabolism, sexual wellness, and prevention—learn more about Revival Women's Health at Revival Women's HealthFollow Dr Taniqua Miller on Instagram @taniquamillermd and Revival Women's Health @joinrevival.Georgia listeners! Dr. Miller has created the medical wellness space for YOU! If you are over the age of 40 and looking for a medical home that listens and honors you, visit us at Revival Women's Health in Decatur, GA. joinrevival.co

Metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH) are rapidly increasing in prevalence, driven by rising rates of obesity, insulin resistance, and other metabolic risk factors. Faculty will review zthe physiologic roles of glucagon and incretin receptor signaling and explan how emerging therapies modulate these pathways to improve liver and cardiometabolic outcomes. Join this program to stay current and gain practical guidance to help improve the care of patients with MASLD/MASH.  CE credits available. 

As part of our summer series, we're revisiting some of the most important conversations we've had on the topics that matter most to our health. And few are more important than heart disease. Heart disease remains the number one cause of death worldwide. Yet despite decades of research, millions of prescriptions, and billions of dollars spent on treatment, many people are still confused about what actually causes it—and what we can do to prevent it. For years, the conversation around heart disease has focused almost entirely on cholesterol. But what if that's only part of the story? In this special compilation episode, you'll hear from Dr. Cindy Geyer of The UltraWellness Center, Dr. Eric Topol, and Dr. Aseem Malhotra as they explore a different perspective on heart disease—one that goes beyond cholesterol and looks at the deeper drivers of cardiovascular risk, including inflammation, insulin resistance, metabolic dysfunction, lifestyle, and early detection. You'll hear why many experts now believe heart disease often begins decades before symptoms appear, why traditional testing can miss important warning signs, and how emerging science is giving us new tools to identify risk earlier than ever before. Most importantly, you'll hear a message that is both practical and hopeful: that many of the factors driving heart disease are within our control, and that prevention remains one of the most powerful tools we have. Let's dive in. View Show Notes From This Episode Sign up for Dr. Hyman's Brainshaping Academy to learn how to nourish the biological systems that support your mental, emotional, and cognitive health https://drhyman.com/products/brainshaping?utm_source=dr_hyman_show&utm_medium=newsletter&utm_campaign=may_27&utm_content=link Get Free Weekly Health Tips from Dr. Hyman https://drhyman.com/pages/picks?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Sign Up for Dr. Hyman's Weekly Longevity Journal https://drhyman.com/pages/longevity?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Join the 10-Day Detox to Reset Your Health https://drhyman.com/pages/10-day-detox Join the Hyman Hive for Expert Support and Real Results https://drhyman.com/pages/hyman-hive This episode is brought to you by BON CHARGE, BIOptimizers, Rho, Made In, Seatopia, and Cozy Earth. Explore red light products at boncharge.com/hyman and enjoy 15% off with code HYMAN. Go to bioptimizers.com/hyman and use code HYMAN to save 15% off your order, plus get a free gift.  Explore science-backed products at rhonutrition.com and use code HYMAN for 20% off the entire site. Upgrade your cookware at madeincookware.com and save 10% off your first order with code HYMAN-HIVE. Find a cleaner source of seafood. Check out seatopia.fish/hyman and receive free shipping on your first order. Head to cozyearth.com to save 20% and upgrade all of your daily essentials today. (0:00) The persistence of heart disease and the low-fat diet hypothesis (0:32) Preventing heart disease through diet, lifestyle, and simple behaviors (2:19) Revisiting key conversations on heart disease (3:44) Beyond cholesterol: deeper drivers and risk factors (7:18) Typical workup, treatments, and advances in cholesterol testing (17:48) Metabolic health, hormonal, and inflammatory factors in heart disease (29:37) Advances in cardiovascular diagnostics and AI (31:31) Impact of lifestyle and new pharmacological treatments (36:55) Statins, side effects, and lipoprotein fractionation (40:13) The role of AI, new diagnostics, and Dr. Topol's journey (43:19) Rethinking treatment: diet, industry influence, and the low-fat craze (45:28) Saturated fat, cholesterol, and revisiting the evidence (48:00) Cholesterol in heart disease risk and systematic drug review (52:31) Insulin resistance, cholesterol's role, and mortality (58:31) Challenges in changing medical dogma (1:00:31) Closing remarks and call to action

Host: Darryl S. Chutka, M.D.  Guest: Regis Fernandes, M.D.  We've known for some time that patients who have hypertension and diabetes are at increased risk for developing subsequent cardiovascular disease and chronic kidney disease. It's now being thought that these health problems are related and interconnected, representing Kidney-Cardiovascular Metabolic Syndrome. They form a pathophysiologic triad driven by shared mechanisms where disease in one system accelerates dysfunction in the others. So, what does this mean for primary care clinicians? Traditionally, we've managed hypertension, diabetes, cardiovascular disease, and chronic kidney disease as separate health conditions. It's now felt that there may be a better approach. The topic for this podcast is “Kidney-Cardiovascular Metabolic Syndrome”, and my guest is Dr. Regis Fernandes, a preventive cardiologist at the Arizona campus of the Mayo Clinic. We'll discuss the science, clinical implications, and recommended management strategies for this health condition.  Connect with us! Mayo Clinic Talks Podcast Season 6 | Mayo Clinic School of Continuous Professional Development 

Attend a Live Q&A with Dr. Glandt. Reigster here.What if the way we treat type 2 diabetes is fundamentally backwards?Dr. Mariela Glandt is an endocrinologist and obesity medicine specialist who spent 15 years practicing conventional medicine before concluding, in her words, that how we treat diabetes “is actually upside down.” As co-founder of OwnaHealth, she focuses on addressing the insulin resistance underlying type 2 diabetes, not only the elevated blood sugar it eventually causes.In this episode, she walks through the science of that shift: why fasting insulin may reveal metabolic dysfunction before A1C becomes abnormal, why a laboratory “normal” range running up to 20 can be misleading, and why she believes repeatedly escalating insulin can contribute to weight gain, reduced insulin responsiveness, and worsening metabolic health.She also shares what she has learned bringing low-carbohydrate and ketogenic therapy to underserved communities in the South Bronx, where patients may be navigating severe diabetes alongside financial pressure, cultural food traditions, psychiatric illness, chronic stress, and conflicting medical advice. Her work shows that these therapies can succeed even in communities facing significant barriers to care.Dr. Glandt also breaks down what GLP-1 medications actually do, where they can help, and what they may leave unresolved—including the risks of muscle loss, inadequate protein intake, and relying on medication without addressing the patient's broader metabolic health.Questions Answered in This Episode:• What key mindset shifts do conventionally trained physicians need to make when transitioning to a more integrated approach to medicine?• How does reframing diabetes as insulin resistance change the way a doctor practices?• What are the earliest signs of metabolic dysfunction that many clinicians miss?• Can ketogenic metabolic therapy succeed in underserved communities?• What do GLP-1 medications actually solve, and what do they leave untouched?• Where can ketogenic therapy and GLP-1 medications work together?• What has Dr. Glandt observed in patients living with both metabolic and psychiatric illness?• Where does endocrinology most need to change course?Viewers will come away with a different lens on metabolic disease, one that looks beyond glucose and weight to the biological, social, and practical factors shaping a patient's health.More links:For Richer, for Poorer: Low-Carb Diets Work for All IncomesOwnaHealth: Reverse the course of chronic disease — for everyone.Special thanks to the sponsors of this episode:✅ Toups and Co – Get 15% off your first order with code METABOLIC here.✅ iRestore – Get a huge discount on the Elite and the Illumina bundle with the code LINK here.In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel!Find us on social: InstagramFacebookYouTubeLinkedInPlease keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.

The Hidden Bile Acid Signaling Network: Why High Performers Create Metabolic Chaos Most people think bile is simply responsible for digesting fat. But what if bile acids are actually one of the most important communication systems in the human body? In this Future You Blueprint™ Rabbit Hole episode, Coach Debbie Potts takes you on a deep dive into the hidden world of bile acid metabolism, metabolic signaling, the microbiome, mitochondrial health, and the nervous system. You'll learn why symptoms like fatigue, brain fog, poor recovery, blood sugar instability, weight loss resistance, digestive complaints, and inflammation may not be isolated problems at all—but clues pointing to a breakdown in communication throughout the body. This episode explores how bile acids act as signaling molecules between the brain, vagus nerve, liver, gallbladder, microbiome, immune system, and mitochondria, and why restoring these signals may be one of the missing links for healthy aging and metabolic resilience. In This Episode You'll Discover: ✔ Why digestion begins in the brain—not the stomach ✔ The connection between vagus nerve function, stomach acid, bile flow, and metabolic health ✔ How protein digestion impacts bile production ✔ Why glycine and taurine are essential for healthy bile metabolism ✔ The difference between primary and secondary bile acids ✔ Which gut bacteria help convert bile acids into powerful signaling molecules ✔ The role of FXR and TGR5 receptors in metabolism, energy production, inflammation, and blood sugar regulation ✔ How low secondary bile acids may contribute to metabolic dysfunction ✔ Why stool test findings are clues, not diagnoses ✔ How the FLOW Method™ and Terrain First™ approach help restore communication throughout the body The Bigger Question We've spent years focusing on symptoms. But what if symptoms are simply messages? What if your fatigue, bloating, poor recovery, hormone imbalances, or weight loss resistance are your body's way of telling you that communication has broken down? Join Debbie as she connects the dots between digestion, bile acid signaling, microbiome function, mitochondrial health, and the Future You you're creating today. Connect with Coach Debbie Potts Website: www.debbiepotts.net Book a Discovery Call: www.debbiepotts.net Learn About PNOĒ Metabolic Testing & The Future You Blueprint™ Follow @coachdebbiepotts on Instagram, YouTube, Facebook, and LinkedIn #FutureYouBlueprint #TerrainFirst #FLOWMethod #MetabolicHealth #BileAcids #RootCauseInvestigation #FunctionalMedicine #GutHealth #HealthyAging #MetabolicChaos #Mitochondria #VagusNerve #Longevity #PNOE

For decades, Polycystic Ovary Syndrome has been the name attached to one of the most common hormonal conditions affecting women worldwide. But the name was always problematic. It pointed to the ovaries as the origin of the condition and created a widespread misunderstanding that led to missed diagnoses, fragmented treatment, and millions of women leaving their appointments with more confusion than clarity. In this episode we unpack exactly why the name failed women and what has finally changed.PCOS Is Now Officially Called PMOSThe American Society for Reproductive Medicine has endorsed a new name for the condition previously known as PCOS. It is now called PMOS, Polyendocrine Metabolic Ovarian Syndrome. The name was developed through a global engagement process involving 56 patient organisations, a survey with 22,000 responses, and workshops with healthcare professionals and women with lived experience. Women with the condition were the biggest drivers of the change. This episode breaks down what the new name means and why every word in it matters.Metabolism and Hormone Communication: The Real Story of PMOSPMOS is not an ovary condition. It is a whole-body metabolic and endocrine condition. That distinction is everything. In this episode we explore how metabolism, insulin physiology, stress response, and hormone communication across the entire body are the real drivers of PMOS symptoms and why understanding this changes the entire approach to healing.Insulin and Reproductive Hormones: The Connection Nobody Told You AboutOne of the most important and most overlooked pieces of the PMOS puzzle is the relationship between insulin and the ovaries. When insulin levels are chronically elevated, as happens with insulin resistance, it signals the ovaries to produce more androgens. Elevated androgens then drive a significant cluster of PMOS symptoms including acne, irregular cycles, hair changes, and weight regulation challenges. This episode explains that connection in clear, accessible language.Why Your Symptoms Overlap and What That Actually MeansAcne. Fatigue. Cravings. Irregular cycles. Mood changes. Weight shifts. For women with PMOS these symptoms can feel random and disconnected. They are not. In this episode we walk through how every major PMOS symptom connects back to the same underlying physiological drivers and why understanding that connection is one of the most empowering things a woman with this condition can do.Why Many Women Feel Confused After a PCOS DiagnosisBeing handed a diagnosis is not the same as being given an education. Most women with PCOS were told very little about what was actually happening in their bodies. Some were given the pill. Some were given a pamphlet. Many were referred to multiple specialists who each addressed one symptom without ever looking at the whole picture. This episode validates that experience and offers the explanation that should have come at diagnosis.Understanding PMOS Beyond Cysts: A Whole Body ApproachMany women diagnosed with PCOS never had ovarian cysts at all. The diagnostic criteria includes three markers and only two are needed for diagnosis. Cysts are just one of those markers. This episode reframes PMOS as what it actually is: a polyendocrine metabolic condition that requires a whole-body, root-cause approach to genuinely support healing.You can take the quiz to discover your root cause hereThe PCOS Supplement GuideLet's continue the conversation on Instagram! What did you find helpful in this episode and what follow-up questions do you have?The full list of Resources & References Mentioned can be found on the Episode webpage at: https://nourishedtohealthy.com/ep-187 

High cholesterol has been treated as the main cause of heart disease for decades. But over the years, I've changed my mind. Today, I believe cholesterol is only part of the story, and that inflammation, insulin resistance, and metabolic health are often the real drivers of cardiovascular disease. In this encore episode, I'm revisiting one of my most talked-about Office Hours conversations to share how my thinking has evolved and why understanding the root cause of heart disease can completely change the way you approach prevention. In today's episode, I discuss: Why cholesterol alone is a poor predictor of heart disease—and the biomarkers I believe matter even more, including ApoB, lipoprotein(a), inflammation, and insulin resistance The surprising role sugar, refined carbohydrates, and metabolic dysfunction play in driving cardiovascular disease Why two people with the same cholesterol can have dramatically different heart disease risk—and how a personalized approach changes the conversation The nutrition, lifestyle, and testing strategies I use to help reduce inflammation, improve metabolic health, and lower cardiovascular risk at its source Heart disease isn't simply a cholesterol problem—it's often a metabolic and inflammatory problem. When you understand what's really driving your risk, you can stop chasing a single number and start addressing the underlying biology that supports lifelong cardiovascular health. Track your metabolic and cardiovascular health biomarkers: functionhealth.com/mark for 160+ lab tests at just $365/year. Use code MARK2026 for $50 off. Have a question you'd love answered on Office Hours? Submit it here' (0:00) The cholesterol and heart disease paradox; introduction and overview of cholesterol, inflammation, and metabolic health (1:11) Sponsor: Function Health (1:41) Traditional views vs. new science on cholesterol, inflammation, and heart disease (4:52) Inflammation and sugar as key factors in heart disease (8:41) Advanced markers: ApoB, lipoprotein fractionation, and comprehensive testing (13:57) Causes of inflammation and holistic heart disease prevention (19:35) Metabolic health risks, new technologies, and personalized interventions (22:35) Diet, exercise, lifestyle, and supplements for heart and metabolic health (25:03) Understanding heart disease beyond cholesterol (25:37) Sponsor: Brain Shaping Academy (26:33) Community engagement, sharing, and final thoughts (28:07) Sponsor acknowledgments and closing remarks

I hear this from so many of my patients: "Dr. Shelly, I haven't changed anything—not my diet, not my exercise—but I'm gaining weight and my body just doesn't respond the way it used to." If you're a woman in your 40s or 50s, you're probably nodding right now. In this episode, I'm walking you through exactly why menopause causes weight gain, why it has nothing to do with willpower, and what breakthrough new research reveals about Foundayo—an oral GLP-1 medication—and how it helps restore the biological signals that become harder to access during this life stage.  I'm sharing real data from the 2026 American Diabetes Association Scientific Conference, including results from the ATTAIN 1 and ATTAIN 2 clinical trials that show meaningful weight loss across all menopausal stages.  But here's what matters most: the goal during menopause isn't just weight loss—it's aging healthy. You'll learn exactly what that looks like and what you need to focus on right now. Episode Highlights: What menopause actually is ( How estrogen decline drives abdominal fat storage and insulin resistance Why muscle loss and poor sleep compound weight gain How GLP-1 medications work—and what they don't do The ATTAIN trials: weight loss results before, during, and after menopause Strength training, protein intake, and the non-negotiables for sustainable results REFERENCES: Menopausal Stage and Weight Outcomes with Orforglipron vs. Placebo: Post Hoc Subgroup Analysis from ATTAIN-1 and ATTAIN-2. Presented at the 86th Scientific Sessions of the American Diabetes Association, June 2026.   Horn DB, et al. Orforglipron, an oral small-molecule GLP-1 receptor agonist, for obesity treatment in adults with type 2 diabetes. Lancet. 2026.   ClinicalTrials.gov. ATTAIN-2 Trial (NCT05872620).   The Menopause Society. Menopause practice recommendations and patient resources on metabolic changes during menopause. Connect with Dr. Alicia Shelly: Website | drshellymd.com Facebook | www.facebook.com/drshellymd Instagram | @drshellymd Linked In | www.linkedin.com/in/drshellymd Twitter | @drshellymd About Dr. Alicia Shelly Dr. Alicia Shelly was raised in Atlanta, GA. She received her Doctorate of Medicine from Case Western Reserve University School of Medicine in Cleveland, OH.  Dr. Shelly has been practicing Primary Care and Obesity medicine since 2014.  In 2017, she became a Diplomat of the American Board of Obesity Medicine. She is the lead physician at the Wellstar Medical Center Douglasville. She started a weekly podcast & Youtube channel entitled Back on Track: Achieving Healthy Weight loss,  where she discusses how to get on track and stay on track with your weight loss journey. She has spoken for numerous local and national organizations, including the Obesity Medicine Association, and the Georgia Chapter of the American Society of Metabolic and Bariatric Surgeons. She has been featured on CNN, Fox 5 News, Bruce St. James Radio show, Upscale magazine, and Shape.com. She was named an honoree of the 2021 Atlanta Business Chronicle's 40 under 40 award. She also is a collaborating author for the, "Made for More: Physician Entrepreneurs who Live Life and Practice Medicine on their own terms''.   Resources: FREE! Discover the 5 Reasons Your Weight-Loss Journey Has Gotten Derailed (And How To Get Back On Track!)

Your body has been talking to you your whole life. The question is whether anyone ever taught you to listen. In this episode, I want to widen the lens on how you read your own body. We have lost so much of the generational knowledge our mothers and grandmothers once passed down, and now we tend to wait until something hurts before we pay attention. But your body speaks in subtleties long before that. I share one of my great loves, Ayurveda, the 5,000-year-old healing system I studied for three years, and its practice of observation called the eightfold examination. What fascinates me most is how closely it aligns with modern functional nutrition's Nutrition Focused Physical Exam. We walk through what your tongue, skin, hair, nails, and eyes may be reflecting about your gut health, your nutrient status, your oxidative stress, and even your blood sugar, backed by research going back nearly 80 years. Here is what matters most. This is not about self-diagnosis. None of these signs are proof of anything on their own. They are invitations to pay attention, not verdicts to fear. My hope is that noticing your body builds confidence instead of anxiety, the quiet confidence of a woman in a loving conversation with her body rather than at war with it. If you take one small thing from this episode, try this. Tomorrow morning, look at your tongue and just notice. Do it for a week. That is the practice.   Resources Mentioned: Work with Laura: https://www.thebreastcancerrecoverycoach.com/health  Download for iPhone:  https://apps.apple.com/us/app/kajabi/id1485646310 Download for Android:  https://play.google.com/store/apps/details?id=kajabi.kajabiapp&hl=en_US Here is the link to the FREE Ayurveda Mini-Course that I talked about in this episode: https://www.thebreastcancerrecoverycoach.com/mybody   Here are the references: Foundational Asif T, Mohiuddin A, Hasan B, Pauly RR. Importance of Thorough Physical Examination: A Lost Art. Cureus. 2017;9(5):e1212. Newton C. The Functional Nutrition-Focused Physical Exam. IFNA Track 3 Module 2. Tongue Jeghers H. Nutrition: the appearance of the tongue as an index of nutritional deficiency. New England Journal of Medicine. 1942;227:221-8. Khayamzadeh M, Najafi S, Sadrolodabaei P, Vakili F, Kharrazi Fard MJ. Determining salivary and serum levels of iron, zinc and vitamin B12 in patients with geographic tongue. J Dent Res Dent Clin Dent Prospects. 2019;13(3):221-226. Chiang CP, Chang JY, Wang YP, Wu YH, Wu YC, Sun A. Atrophic glossitis: Etiology, serum autoantibodies, anemia, hematinic deficiencies, hyperhomocysteinemia, and management. J Formos Med Assoc. 2020;119(4):774-780. Skin Salem I, Ramser A, Isham N, Ghannoum MA. The Gut Microbiome as a Major Regulator of the Gut-Skin Axis. Front Microbiol. 2018;9:1459. Wang X, Li Y, Wu L, et al. Dysregulation of the gut-brain-skin axis and key overlapping inflammatory and immune mechanisms of psoriasis and depression. Biomed Pharmacother. 2021;137:111065. Jafferany M, Franca K. Psychodermatology: Basics Concepts. Acta Derm Venereol. 2016;96(217):35-7. Reunala T, Salmi TT, Hervonen K, Kaukinen K, Collin P. Dermatitis Herpetiformis: A Common Extraintestinal Manifestation of Coeliac Disease. Nutrients. 2018;10(5):602. Stefanadi EC, Dimitrakakis G, Antoniou CK, et al. Metabolic syndrome and the skin: a more than superficial association. Diabetol Metab Syndr. 2018;10:9. Hair O'Connor K, Goldberg LJ. Nutrition and hair. Clin Dermatol. 2021;39(5):809-818. Arck PC, Overall R, Spatz K, et al. Towards a "free radical theory of graying": melanocyte apoptosis in the aging human hair follicle is an indicator of oxidative stress induced tissue damage. FASEB J. 2006;20(9):1567-9. Zhang B, Ma S, Rachmin I, et al. Hyperactivation of sympathetic nerves drives depletion of melanocyte stem cells. Nature. 2020;577(7792):676-681. Poonia K, Bhalla M. Premature Graying of Hair: A Comprehensive Review and Recent Insights. Indian Dermatol Online J. 2024;15(5):721-731. Nails Singal A, Arora R. Nail as a window of systemic diseases. Indian Dermatol Online J. 2015;6(2):67-74. Cashman MW, Sloan SB. Nutrition and nail disease. Clin Dermatol. 2010;28(4):420-5. Eyes Knapp A. The Eye as a Guide to Latent Nutritional Deficiency Diseases. Bull N Y Acad Med. 1946. Wakamatsu TH, Dogru M, Tsubota K. Tearful relations: oxidative stress, inflammation and eye diseases. Arq Bras Oftalmol. 2008;71(6 Suppl):72-9. Seydou A, Arnould L, Gabrielle PH, et al. Plasma Fatty Acids Pattern and Dry Eye Disease in the Elderly: The Montrachet Population-Based Study. Nutrients. 2022;14(11):2290. Bu Y, Shih KC, Tong L. The ocular surface and diabetes, the other 21st Century epidemic. Exp Eye Res. 2022;220:109099. Rahman A, Yahya K, Ahmed T, Sharif-Ul-Hasan K. Diagnostic value of tear films tests in type 2 diabetes. J Pak Med Assoc. 2007;57(12):577-81. Seifart U, Strempel I. Trockenes Auge und Diabetes mellitus [The dry eye and diabetes mellitus]. Ophthalmologe. 1994;91(2):235-9. Campagnoli LIM, Varesi A, Barbieri A, Marchesi N, Pascale A. Targeting the Gut-Eye Axis: An Emerging Strategy to Face Ocular Diseases. Int J Mol Sci. 2023;24(17):13338. Let's Connect! If this episode helped you breathe a little easier, please share it with a friend or leave a review. Every share helps spread this message of hope, healing, and whole-person wellness.

In this Sister Solo, Jenna walks through the 5 pillars that finally healed her after years of chronic gut issues, inflammation, bloating, hormonal acne, and feeling like sh*t no matter what she tried.If you've been doing all the "right" wellness things — eating clean, drinking water, taking supplements — and you still feel exhausted, bloated, or stuck in your body, this episode is for you.Jenna and Jill get real about Jenna's 2019-2023 era — the symptoms she normalized, the all-or-nothing trap that made her sicker, and the moment she realized the answer wasn't more restriction. It was less.We walk through the exact 5-pillar framework that changed everything — including the pillar nobody in wellness wants to talk about.In this episode:Jenna's "before" era: the symptoms she normalized that weren't normalThe all-or-nothing wellness trap and how it made her sickerPillar 1: Drainage — the foundation nobody talks aboutPillar 2: Gut health — and why probiotics aren't the answerPillar 3: Metabolic health — and why undereating is making women sickerPillar 4: Strength training — the day everything changedPillar 5: Curating a slower, intentional, balanced life — the pillar nobody talks aboutThe toxic friend auditWhat every woman feeling stuck in her body needs to hearConnect with us:Follow Gut Talk on Instagram: @guttalkpodcastIf this episode resonated, share it with a friend who needs to hear it.

Show notes at pharmacyjoe.com/episode1142 In this episode, I'll discuss sodium bicarbonate for critically ill adult patients with metabolic acidosis and shock.

Howard and guest hose Sivani Aluru unpack why the new PMOS name matters, how PCOS got tied to “cysts,” and what the evidence actually says about diagnosis, metabolic risk, and treatment. We also challenge a few habits we have all inherited, from pre-op antibiotic dosing to the way we talk about hormones, weight, and fertility with patients. • the evidence gap behind 2 g vs 3 g cefazolin in obese cesarean patients and how practice inertia forms • why PMOS shifts attention toward insulin resistance, metabolic screening, and multidisciplinary care • how NIH, Rotterdam, and androgen excess criteria shape who gets diagnosed and who gets missed • SHBG and free testosterone as a practical way to explain symptoms when total testosterone looks normal • why ovarian follicles are not the same as painful ovarian cysts and why ultrasound can mislead • patient frustration with “just take birth control” and how we explain progesterone protection for the endometrium • lean PMOS, weight-focused bias, and realistic conversations about lifestyle change, GLP-1s, and bariatric surgery • fertility takeaways from PPCOS II, metformin limitations, and what lifestyle trials suggest preconception Be sure to check out thinkingaboutobgyn.com for more information, and be sure to follow us on Instagram.0:00 Welcome And Guest Introduction2:01 The 3-Gram Ancef Habit12:02 PCOS Becomes PMOS12:55 How The Criteria Got Complicated22:00 Insulin Resistance And Free Testosterone30:40 Hormone Panels And TikTok Myths32:30 Ovarian Follicles Are Not “Cysts”36:03 Treating Symptoms Without Dismissing People46:12 Fertility Trials And Lifestyle Results57:27 ACOG At 75 And Why JoinFollow us on Instagram @thinkingaboutobgyn.

GLP-1 medications are everywhere in metabolic health conversations, but weight loss doesn't equal metabolic restoration. Appetite suppression without strategy can compromise muscle, nutrient status, digestion, and long-term resilience.In this episode, Dr. Ritamarie walks through a functional practitioner's approach to GLP-1s, including how to protect lean mass, maintain nutrient density, optimize metabolic flexibility, and support digestion while using these medications. Learn why context matters more than the number on the scale and how to create a sustainable, clinically precise plan.What's Inside This EpisodeWhy weight loss is not the same as metabolic restorationHow GLP-1s affect appetite, digestion, and nutrient intakeProtecting muscle and functional strength while on these medicationsKey labs and markers to track metabolic resilienceHow diet, protein, fiber, phytonutrients, and exercise fit inRisks of nutrient depletion, slowed digestion, and functional declineHow to help clients transition off GLP-1s without losing metabolic gainsPractical steps for integrating GLP-1s into a systems-based metabolic strategyResources and LinksDownload the full transcript hereGet your FREE guide: Beyond Protocols: A Practitioner's Guide to Root Cause Pattern Recognition for a structured framework to integrate symptoms, systems, and sequence in complex casesAccess the Genetic Pathway Mapping Workshop Replay to learn a clinical framework for identifying genetic patterns and applying targeted epigenetic strategies. Approximately 2 hours of training.Join the Next-Level Health Practitioner Facebook group here for free resources and community supportVisit INEMethod.com for advanced health practitioner training and tools to elevate your clinical skills and grow your practice by getting life-changing results. Check out other podcast episodes here

Dr. Steven Noseworthy discusses the pitfalls of the DIY health trend and the importance of addressing root cause disruptors before employing longevity hacks. He introduces the concept of the health journey, consisting of three stages: restoration, optimization, and vitality. The restoration stage focuses on identifying root causes and restoring baseline function.TakeawaysAddressing root cause disruptors is essential before employing longevity hacks.The health journey consists of three stages: restoration, optimization, and vitality.Full video episode on YouTube - link in Bio.Prefer audio? Listen on Apple and Spotify.https://www.drnoseworthy.com/site/contactKey TopicsThe importance of foundational health and metabolic stabilityThe pitfalls of high-volume, cookie-cutter medical practicesThe three stages of the health journey: restoration, optimization, vitalityThe hierarchy of human physiology: perfusion, energy, and resilienceThe need for personalized, stage-specific interventionsTakeawaysAddress root causes before adopting longevity hacks.Metabolic reprogramming resists change; you can't outmedicate it.High-volume practices may hinder personalized care.Health is better defined by metabolic resilience than absence of disease.The health journey has three stages: restore, optimize, build vitality.guest nameChapters00:00Introduction and the importance of rethinking health practices00:17The risks of cookie-cutter high-volume medical models01:09The obsession with longevity and DIY health hacks02:03Metabolic reprogramming and why shortcuts fail02:57The first stage of the health journey: restoration07:27Mapping the health journey: from restoration to vitality08:21The three stages of the health journey explained09:45The importance of identifying root causes in health11:36The value of baseline evaluation and personalized plans13:27Redefining health: metabolic stability and resilience14:44The hierarchy of human function and fundamental health15:12Fundamentals of metabolic health and energy mechanics17:27The transition from active problem solving to maintenance

Natasha believes that healthy is a  lifestyle and not just a diet that can be handed to you.  Where, how and when we eat can have just as much of an effect as what we eat.  Addressing things like circadian rhythms, cycle timing, nervous system tone, mindset, sleep - is where she has seen coaching make huge shifts, especially when it comes to women who have daily, weekly and hormonal monthly variations.  After graduating as a Holistic Nutritionist in 2010 and as a practicing Metabolic Health Coach, Natasha realized health is not a one size fits all approach. By addressing metabolism,  getting back to giving ourselves what we evolved to eat, moving the way we are intended to move, and taking our health into our own hands - life opens up and really begins to shine.     IG: vazwellness FB: PNWmetabolic Website: https://www.pnwmetabolic.com Timestamps: 00:00 Trailer 00:31 Introduction 05:27 Considering a career in nutrition 10:11 Discussing dietary documentaries 11:04 Challenges of northern diets 14:21 Embracing local and sustainable eating 17:47 Switching to a carnivore diet 22:48 Discussing insulin resistance and gut health 24:35 Improving health with dietary changes 29:22 Understanding different types of hunger 33:50 Exploring Carnivore diet and fasting 35:14 Clinicians sharing personal diet experiences 38:29 Buying beef directly from farmer 41:48 Empowerment through personal health Join Revero now to regain your health: https://revero.com/YT Revero.com is an online medical clinic for treating chronic diseases with this root-cause approach of nutrition therapy. You can get access to medical providers, personalized nutrition therapy, biomarker tracking, lab testing, ongoing clinical care, and daily coaching. You will also learn everything you need with educational videos, hundreds of recipes, and articles to make this easy for you. Join the Revero team (medical providers, etc): https://revero.com/jobs ‪#Revero #ReveroHealth #shawnbaker  #Carnivorediet #MeatHeals #AnimalBased #ZeroCarb #DietCoach  #FatAdapted #Carnivore #sugarfree Disclaimer: The content on this channel is not medical advice. Please consult your healthcare provider.

Research Shows Possible Metabolic Links Between Periodontitis and a High-fat DietBy Today's RDH ResearchOriginal article published on Today's RDH: https://www.todaysrdh.com/research-shows-possible-metabolic-links-between-periodontitis-and-a-high-fat-diet/Need CE? Start earning CE credits today at ⁠https://rdh.tv/ce⁠ Get daily dental hygiene articles at ⁠https://www.todaysrdh.com⁠ Follow Today's RDH on Facebook: ⁠https://www.facebook.com/TodaysRDH/⁠Follow Kara RDH on Facebook: ⁠https://www.facebook.com/DentalHygieneKaraRDH/⁠Follow Kara RDH on Instagram: ⁠https://www.instagram.com/kara_rdh/⁠

Jay breaks down why most “metabolism reset” programs fail and reveals a smarter, research-backed 30-day approach that actually works. Drawing from decades of experimentation and human studies, he dives into the real science of adaptive thermogenesis, the dangers of yo-yo dieting, and how to rebuild your hormonal environment for lasting results.Key topics include:Strategic diet breaks at maintenance calories to reverse metabolic slowdownHigh-protein intake and resistance training to positive muscular failure (PMF)Alternate-day fasting, metabolic flexibility, and smart HIIT protocolsThe role of peptides and targeted compounds to accelerate repairWhy muscle preservation is the ultimate key to a thriving metabolismIf you're tired of crash diets that leave you worse off, this conversation delivers practical, no-BS strategies to reignite your metabolism, preserve muscle, and build sustainable habits that support your long-term health, energy, and purpose.Jay also shares insights from his 30 Days 2 Shredz protocol and Metabolic Awakening framework—tools designed to help you stop fighting your biology and start working with it.https://jaycampbell.com/Become a supporter of this podcast: https://www.spreaker.com/podcast/i-am-refocused-radio--2671113/support.Subscribe now at YouTube.com/@RefocusedNetworkThank you for your time. 

A patient asked me this recently: "Dr. Shelley, I've heard that GLP-1 medications can cause muscle loss. Does that mean they can hurt my bones too?" It's an excellent question—and one we don't talk about nearly enough. In this episode, I'm walking you through what the research actually shows about GLP-1 medications and bone health, why weight loss itself poses a different risk to your skeleton, and the five non-negotiable steps you need to take to protect your bones while losing weight. This is the bone health conversation you need to hear before—or while—taking a GLP-1. Episode Highlights: What GLP-1 medications are and how they work in your body Does GLP-1 directly damage bones? What the research says The real issue: weight loss and how it affects bone health How your bones stay strong and why muscle matters Muscle loss during weight loss on GLP-1s (body composition breakdown) Who's at higher risk for weak bones and should be monitoring Eat enough protein: how much you actually need Strength training and resistance exercises for bone protection Getting enough calcium and vitamin D The DEXA bone density scan and when you should ask for one Connect with Dr. Alicia Shelly: Website | drshellymd.com Facebook | www.facebook.com/drshellymd Instagram | @drshellymd Linked In | www.linkedin.com/in/drshellymd Twitter | @drshellymd About Dr. Alicia Shelly Dr. Alicia Shelly was raised in Atlanta, GA. She received her Doctorate of Medicine from Case Western Reserve University School of Medicine in Cleveland, OH.  Dr. Shelly has been practicing Primary Care and Obesity medicine since 2014.  In 2017, she became a Diplomat of the American Board of Obesity Medicine. She is the lead physician at the Wellstar Medical Center Douglasville. She started a weekly podcast & Youtube channel entitled Back on Track: Achieving Healthy Weight loss,  where she discusses how to get on track and stay on track with your weight loss journey. She has spoken for numerous local and national organizations, including the Obesity Medicine Association, and the Georgia Chapter of the American Society of Metabolic and Bariatric Surgeons. She has been featured on CNN, Fox 5 News, Bruce St. James Radio show, Upscale magazine, and Shape.com. She was named an honoree of the 2021 Atlanta Business Chronicle's 40 under 40 award. She also is a collaborating author for the, "Made for More: Physician Entrepreneurs who Live Life and Practice Medicine on their own terms''.   Resources: FREE! Discover the 5 Reasons Your Weight-Loss Journey Has Gotten Derailed (And How To Get Back On Track!)

If you've ever wondered why weight loss gets harder the longer you diet, why every expert seems to have a different answer, or whether you really need to count calories to lose fat, this episode is for you.In Part 1 of this 4-part nutrition series, Britany breaks down the foundation of fat loss: calorie deficits, metabolism, metabolic adaptation, and why preserving muscle matters just as much as losing weight. She also explains why crash diets backfire, how popular diets actually work, and what women in perimenopause and menopause need to know about fat loss.In this episode, we discuss: What a calorie deficit actually is  The 4 ways your body burns calories  Why daily movement matters more than most people realize  Metabolic adaptation and why weight loss slows over time  Why bigger calorie deficits aren't always better  How keto, intermittent fasting, paleo, and other diets really work  The difference between weight loss and fat loss  Why preserving muscle is critical during a fat-loss phase  How strength training supports fat loss  The role of muscle in metabolism and long-term success  Fat loss during perimenopause and menopause  Why aggressive dieting often backfiresMentioned in the podcast:Free calorie calculatorSIGN UP FOR BRITANY'S NEWSLETTERhttps://britany.myflodesk.com/filterfreeASK BRITANY A QUESTION OR REQUEST A TOPIChttps://forms.gle/j9NC3yM5vrdBs8mJ8

Send us Fan MailThe possible role of deuterium (heavy isotope of hydrogen) in regulating cell division, mitochondrial metabolism & cancer.TOPICS DISCUSSED:Deuterium Basics: Deuterium is twice as massive as regular hydrogen; natural water contains ~150 ppm, with stronger oxygen-deuterium bonds slowing reactions compared to oxygen-hydrogen.Mitochondrial Role: Healthy mitochondria produce deuterium-depleted metabolic water (~110 ppm from fat oxidation vs. ~150 ppm from carbs), helping maintain low cellular D:H ratios.Cell Growth Regulation: Lower deuterium slows cell division in vitro; cells sense small D:H changes, with higher levels (near/above 150 ppm) promoting growth.In Vitro Evidence: DDW (e.g., 25-125 ppm) can reduce proliferation and alters cancer-related gene expression.Animal Models: DDW caused tumor regression in mice with transplanted human cancers and showed possible efficacy in veterinary use for dogs and cats.Human Prostate Cancer: Phase 2 randomized study showed greater Prostate-Specific Antigen (PSA) reduction, tumor shrinkage, and better 1-year survival with DDW plus standard therapy vs. placebo.Dietary Modulation: Ketogenic/high-fat diets lower body deuterium from lipid oxidation.Broader Implications: Potential in neurodegeneration models; larger trials needed for registration as adjunct cancer therapy.ABOUT THE GUEST: Gábor Somlyai, PhD is a molecular biologist who pioneered deuterium depletion studies at the National Institute of Oncology in Hungary. His primary work focuses on the role of deuterium in living organisms and the development of deuterium-depleted water for cancer therapy.Support the showHealth Products by M&M Partners:AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models.OmegaQuant: At-home blood testing to see fatty acid profiles, including omega-3 fatty acids. Use link to see options and support M&M.SiPhox Health: Comprehensive, cost-effective bloodwork from the comfort of home. Use code TRIKOMES for 20% off.KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime)SporesMD: Premium mushrooms products (gourmet mushrooms, nootropics, research). Use code 'nickjikomes' for 20% off.For all the ways you can support my efforts

Metabolic syndrome now affects about 1 in 4 adults worldwide, with cases rising rapidly across nearly every country and age group, which means your personal risk is higher than it was just a generation ago The condition develops silently through a combination of abdominal fat, high blood sugar, high blood pressure, and abnormal cholesterol, often without clear symptoms until damage is already underway Your daily habits drive the condition, as processed foods, low movement, chronic stress, and poor sleep disrupt how your body produces and uses energy Insulin resistance sits at the center of the problem, creating a chain reaction that affects your metabolism, blood vessels, and hormone balance all at once You can reverse the trajectory by restoring cellular energy through better food choices, eliminating seed oils, increasing daily movement, getting regular sunlight, and improving sleep and stress control

Fewer than 40% of people with PTSD respond to standard care. For the intrusive symptoms at the core of the disorder, response rates may be lower than 15%. So what options remain for patients who have not responded to existing treatments?Dr. Keren Doenyas-Barak, director of the PTSD program at the Sagol Center for Hyperbaric Medicine and Research and a faculty member at Tel Aviv University, has treated close to 1,000 civilian and military patients and led sham-controlled trials that are helping reshape how hyperbaric medicine is studied.She walks host Dr. Dominic D'Agostino through the protocol her clinic uses—60 sessions over 12 weeks, with oxygen cycled at two atmospheres—the 35% CAPS-score improvement associated with continued progress after treatment ends, and the reported two-year outcomes, including improved occupational function, roughly double the proportion of patients living with a partner, and sharp drops in benzodiazepine and cannabis use. She also details the convincing sham control her team engineered after concluding that earlier placebo arms may have delivered a physiologically active dose.Questions Answered in This Episode:What hyperbaric protocol is best supported for treatment-resistant PTSD?What does a 35% reduction in CAPS score predict about long-term recovery?Which outcomes beyond symptom scores changed most for patients?How did the team build a hyperbaric sham that patients genuinely could not detect?Which safety measures are non-negotiable in a hyperbaric PTSD clinic?Does a patient's baseline metabolic fitness predict their response to HBOT, and can the treatment affect cardiometabolic risk?A rigorous, frontline examination of what responsible hyperbaric medicine actually requires, led by a clinician helping to build its evidence base.Special thanks to the sponsors of this episode:✅ Toups and Co – Get 15% off your first order with code METABOLIC here.✅ iRestore – Get a huge discount on the Elite and the Illumina bundle with the code LINK here.✅ MudWtr – Get up to 43% off + free shipping and a free rechargeable frother with code METABOLICLINK here.In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel!Find us on social: InstagramFacebookYouTubeLinkedInPlease keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.

Jun 15, 2026 – Metabolic health expert Jim LaValle joins Jim Puplava to explain why being "disease free" doesn't mean you're truly healthy. They explore the overlooked drivers of premature aging, including chronic stress, poor sleep, and insulin resistance...

If you enjoy this episode, we're sure you will enjoy more content like this on The Occult Rejects.  In fact, we have curated playlists on occult topics like grimoires, esoteric concepts and phenomena, occult history, analyzing true crime and cults with an occult lens, Para politics, and occultism in music. Whether you enjoy consuming your content visually or via audio, we've got you covered - and it will always be provided free of charge.  So, if you enjoy what we do and want to support our work of providing accessible, free content on various platforms, please consider making a donation to the links provided below.  Thank you and enjoy the episode!Links For The Occult Rejectshttps://linktr.ee/theoccultrejectsOccult Research Institutehttps://www.occultresearchinstitute.org/Substackhttps://substack.com/@theoccultrejects?r=7auau0&utm_campaign=profile&utm_medium=profile-pageCash Apphttps://cash.app/$theoccultrejectsVenmo@TheOccultRejectsBuy Me A Coffeebuymeacoffee.com/TheOccultRejectsPatreonhttps://www.patreon.com/TheOccultRejectsBiblioBernardi, Luciano, Peter Sleight, Gabriele Bandinelli, Simone Cencetti, Luciano Fattorini, Johanna Wdowczyc-Szulc, and Alfonso Lagi. “Effect of Rosary Prayer and Yoga Mantras on Autonomic Cardiovascular Rhythms: Comparative Study.” BMJ 323, no. 7327 (2001): 1446–1449.Benson, Herbert, John W. Lehmann, Mark S. Malhotra, Ralph F. Goldman, Jeffrey Hopkins, and Mark D. Epstein. “Body Temperature Changes During the Practice of g Tum-mo Yoga.” Nature 295 (1982): 234–236.Benson, Herbert, Mark S. Malhotra, Ralph F. Goldman, Gregory D. Jacobs, and Jeffrey Hopkins. “Three Case Reports of the Metabolic and Electroencephalographic Changes During Advanced Buddhist Meditation Techniques.” Behavioral Medicine 16, no. 2 (1990): 90–95.Bremer, Brandon, Lorenzo Wu, Zoran Josipovic, and colleagues. “Mindfulness Meditation Increases Default Mode, Salience, and Central Executive Network Connectivity.” Scientific Reports 12 (2022).Brewer, Judson A., Patrick D. Worhunsky, Jeremy R. Gray, Yi-Yuan Tang, Jochen Weber, and Hedy Kober. “Meditation Experience Is Associated with Differences in Default Mode Network Activity and Connectivity.” Proceedings of the National Academy of Sciences 108, no. 50 (2011): 20254–20259.Britton, Willoughby B. and colleagues. Research associated with the “Varieties of Contemplative Experience” project on meditation-related challenges, adverse effects, and safety considerations in contemplative practice.Crowley, Aleister. Liber E vel Exercitiorum sub figura IX. In the A∴A∴ training corpus. Relevant sections include asana, pranayama, and dharana as foundational magical exercises.Dennison, Paul. “Insights From an EEG Study of Buddhist Jhāna Meditation.” Frontiers in Human Neuroscience 13 (2019).Fialoke, Shantala, Helen Weng, and colleagues. “Functional Connectivity Changes in Meditators and Novices During Yoga Nidra Practice.” Scientific Reports 14 (2024).Fox, Kieran C. R., Savannah Nijeboer, Matthew L. Dixon, James L. Floman, Melissa Ellamil, Samuel P. Rumak, Peter Sedlmeier, and Kalina Christoff. “Is Meditation Associated with Altered Brain Structure? A Systematic Review and Meta-analysis of Morphometric Neuroimaging in Meditation Practitioners.” Neuroscience & Biobehavioral Reviews 43 (2014): 48–73.Hölzel, Britta K., James Carmody, Mark Vangel, Christina Congleton, Sita M. Yerramsetti, Tim Gard, and Sara W. Lazar. “Mindfulness Practice Leads to Increases in Regional Brain Gray Matter Density.” Psychiatry Research: Neuroimaging 191, no. 1 (2011): 36–43.Kozhevnikov, Maria, Olesya Louchakova, Zoran Josipovic, and Michael A. Motes. “The Enhancement of Visuospatial Processing Efficiency Through Buddhist Deity Meditation.” Psychological Science 20, no. 5 (2009): 645–653.Kozhevnikov, Maria, John A. Elliott, Jennifer Shephard, and Klaus Gramann. “Neurocognitive and Somatic Components of Temperature Increases During g-Tummo Meditation: Legend and Reality.” PLOS ONE 8, no. 3 (2013): e58244.Laukkonen, Ruben E., and Heleen A. Slagter. “From Many to (N)one: Meditation and the Plasticity of the Predictive Mind.” Neuroscience & Biobehavioral Reviews 128 (2021): 199–217.Lomas, Tim, Juan Carlos Ivtzan, and Itai K. Fu. “A Systematic Review of the Neurophysiology of Mindfulness on EEG Oscillations.” Neuroscience & Biobehavioral Reviews 57 (2015): 401–410.Lott, James P., Richard J. Davidson, John D. Dunne, Thupten Jinpa, Antoine Lutz, and colleagues. “No Detectable Electroencephalographic Activity After Clinical Declaration of Death Among Tibetan Buddhist Meditators in Apparent Tukdam.” Frontiers in Psychology 11 (2021): 599190.Lutz, Antoine, Lawrence L. Greischar, Nancy B. Rawlings, Matthieu Ricard, and Richard J. Davidson. “Long-term Meditators Self-induce High-amplitude Gamma Synchrony During Mental Practice.” Proceedings of the National Academy of Sciences 101, no. 46 (2004): 16369–16373.Lutz, Antoine, Julie Brefczynski-Lewis, Tom Johnstone, and Richard J. Davidson. “Regulation of the Neural Circuitry of Emotion by Compassion Meditation: Effects of Meditative Expertise.” PLoS ONE 3, no. 3 (2008): e1897.Matko, Karin, Peter Sedlmeier, and colleagues. “Adverse Effects of Meditation and Mindfulness in Clinical Practice.” 2025.Patanjali. Yoga Sutras. Especially Book III, traditionally describing dharana, dhyana, and samadhi.Riegner, Gretchen, Fadel Zeidan, and colleagues. “Disentangling Self from Pain: Mindfulness Meditation-Induced Pain Relief Is Driven by Thalamic-Default Mode Network Decoupling.” Pain 164, no. 2 (2023): 280–291.Tang, Yi-Yuan, Britta K. Hölzel, and Michael I. Posner. “The Neuroscience of Mindfulness Meditation.” Nature Reviews Neuroscience 16 (2015): 213–225.Vago, David R., and David A. Silbersweig. “Self-awareness, Self-regulation, and Self-transcendence: A Framework for Understanding the Neurobiological Mechanisms of Mindfulness.” Frontiers in Human Neuroscience 6 (2012): 296.Zeidan, Fadel, and colleagues. Research on mindfulness meditation, pain modulation, attention, and the neural mechanisms of pain relief.Slagter, Heleen A., Antoine Lutz, Lawrence L. Greischar, Andrew D. Francis, Sander Nieuwenhuis, James M. Davis, and Richard J. Davidson. “Mental Training Affects Distribution of Limited Brain Resources.” PLOS Biology 5, no. 6 (2007): e138. Use for: Attentional blink, limited attention, and meditation changing how the brain allocates resources.Hölzel, Britta K., James Carmody, Mark Vangel, Christina Congleton, Sita M. Yerramsetti, Tim Gard, and Sara W. Lazar. “Mindfulness Practice Leads to Increases in Regional Brain Gray Matter Density.” Psychiatry Research: Neuroimaging 191, no. 1 (2011): 36–43. Use for: Neuroplasticity, repeated practice leaving measurable marks on the brain, and the “practice writes itself into the practitioner” idea.Laukkonen, Ruben E., and Heleen A. Slagter. “From Many to (N)one: Meditation and the Plasticity of the Predictive Mind.” Neuroscience & Biobehavioral Reviews 128 (2021): 199–217. Use for: Predictive processing, the brain as a prediction machine, meditation loosening automatic models, and the “veil” argument.Lutz, Antoine, Julie Brefczynski-Lewis, Tom Johnstone, and Richard J. Davidson. “Regulation of the Neural Circuitry of Emotion by Compassion Meditation: Effects of Meditative Expertise.” PLOS ONE 3, no. 3 (2008): e1897. Use for: Compassion meditation, loving-kindness, emotional circuitry, and training compassion as a repeatable state rather than just a moral idea.Kok, Bethany E., Kimberly A. Coffey, Michael A. Cohn, Lahnna I. Catalino, Tanya Vacharkulksemsuk, Sara B. Algoe, Marc A. Brantley, and Barbara L. Fredrickson. “How Positive Emotions Build Physical Health: Perceived Positive Social Connections Account for the Upward Spiral Between Positive Emotions and Vagal Tone.” Psychological Science 24, no. 7 (2013): 1123–1132. Use for: Loving-kindness, social connection, vagal tone, and the cautious “social nervous system” bridge.Black, David S., and George M. Slavich. “Mindfulness Meditation and the Immune System: A Systematic Review of Randomized Controlled Trials.” Annals of the New York Academy of Sciences 1373, no. 1 (2016): 13–24. Use for: Immune-system caution, inflammation markers, cell-mediated immunity, biological aging, and why this material should be framed as tentative rather than miracle healing.Burić, Ivana, Miguel Farias, Jonathan Jong, Christopher Mee, and Inti A. Brazil. “What Is the Molecular Signature of Mind–Body Interventions? A Systematic Review of Gene Expression Changes Induced by Meditation and Related Practices.” Frontiers in Immunology 8 (2017): 670. Use for: Stress biology, inflammatory gene expression, NF-kB-related language, and the cautious claim that mind-body practices may affect biology below ordinary mood.Also want to remind people about the website, if you're into reading we have tons of information by multiple contributors, and we got t-shirts up on the site if you're interested. Fun fact, the art is all based on the eyeball. A

Discover why hormones are off and what's really driving the imbalance. In this episode, we break down five root causes — from gut dysfunction and disrupted sleep to chronic stress, appetite dysregulation, and omega-3 deficiency — and walk through what you can actually do to fix it. FEATURED PRODUCT Berberine is a powerful botanical compound that acts as a natural GLP-1 supporter — the same metabolic pathway targeted by medications like Ozempic — helping regulate blood sugar, reduce insulin resistance, and restore appetite signaling from the gut. Since metabolic hormones like insulin and leptin are the first to derail your entire hormone cascade, Berberine directly addresses one of the deepest root causes discussed in this episode. It also supports gut microbiome diversity, making it a foundational tool for anyone working to reclaim hormonal balance naturally.

** Come to Macro ‘n Chill, the online gathering where we listen to the podcast together and discuss what we learned and where we agree or disagree. Tuesday, June 16, 8pm ET/5pm PT. Use this link to register: https://us06web.zoom.us/meeting/register/Qm85bGIOSF2H_uNMwOmWtQEcosocialist author, Ian Angus, talks with Steve about his book Metabolic Rifts: Capitalism's Assault on the Earth System. They explore the deep, sometimes invisible ways that capitalism disrupts the planet's fundamental life cycles –– from soil depletion and artificial fertilizers to the carbon cycle driving global warming.Ian traces the concept of “metabolic rift” from Marx and Engels through a long socialist lineage, making the case that ecological critique has always been central to the Marxist tradition. (Indeed, some Marxists might argue that “eco-” is an unnecessary qualifier; “socialism” is enough!)Steve brings up the MMT basics challenging the austerity narrative that blocks ecological reconstruction. He reminds us that the state, as the currency issuer, can de-commodify the essentials of life, namely food, water, housing, and healthcare. However, as Ian bluntly states: “The problem is that it's not our government, it's their government.” Reformism and electoralism are dead ends.While listeners may disagree with some of Ian's interpretations of Soviet history, those comments do not negate the episode's compelling analysis that capitalism's DNA demands endless accumulation and profit. Combating the ecological crisis is inseparable from the struggle to overcome capitalism.Ian Angus is founder and editor of the online ecosocialist journal, Climate & Capitalism and a founding member of the Global Ecosocialist Network. Among his many books are The War Against the Commons: Dispossession and Resistance in the Making of Capitalism (Monthly Review Press, 2023), A Redder Shade of Green: Intersections of Science and Socialism (Monthly Review Press, 2017) and Facing the Anthropocene: Fossil Capitalism and the Crisis of the Earth System (Monthly Review Press, 2016). His most recent is Metabolic Rifts: Capitalism's Assault on the Earth System. (Monthly Review Press, 2026),@ecosocialism1 on X

Today we have Dr. Dominic D'Agostino, who over the past 10 years has been a frequent guest on STEM-Talk. Today Dom joins us to give us an update on his recent research into ketogenic metabolic therapies, ketone supplements as well as hyperbaric oxygen therapy for traumatic brain injuries. Dom and his lab at the University of South Florida have published more than 20 papers since his last appearance on STEM-Talk in 2023. Dom is an Associate Professor in the Department of Molecular Pharmacology and Physiology at South Florida's Morsani College of Medicine. Dom has a background in neuroscience, molecular pharmacology, nutrition and physiology. In addition to developing and testing metabolic-based therapies, Dom's lab also investigates seizure disorders, brain cancer, neurodegenerative diseases and rare genetic-metabolic disorders. Show notes: [00:03:28] Dawn welcomes Dom back to the show and explaining that he has been quite busy since his last appearance, authoring or co-authoring more than 20 papers. Over the past several years, Dom has been helping to advance the science and application of ketogenic metabolic therapy (KMT) with colleagues at Moffitt Cancer Center, particularly focusing on using KMT to enhance immune-based therapies for certain types of cancers. Dawn asks Dom about this collaboration. [00:05:04] Dawn explains that ketogenic metabolic therapy is a dietary approach that focuses on a high-fat/low-carb diet to reduce glucose availability for cancer cells, potentially slowing their growth and improving treatment outcomes. It has been explored as a complimentary treatment for a variety of cancers including gliomas by shifting the metabolism of tumor cells away from glucose. Dawn asks Dom to explain what is involved in KMT. [00:06:58] Dawn clarifies that KMT requires less than 20-25 grams of carbohydrates per day, and that ketosis is a metabolic state in which the body switches from glucose metabolism to metabolizing fats in the form of ketones. Dawn goes on to explain that cancer cells typically consume glucose at a higher rate than normal cells. However, cancer cells are also very adaptable, and Dawn asks Dom to talk about this feature of cancer cells. [00:09:14] Ken explains that KMT has shown the most promise in treating high-grade gliomas, or brain cancers, such as glioblastoma, which is the most aggressive primary brain tumor in adults. Ken explains that Dom was part of a massive review titled “Clinical research framework proposal for ketogenic metabolic therapy in glioblastoma,” which proposed guidelines for the management of glioblastoma based on an understanding of cancer as a metabolic disease, particularly involving mitochondria. Ken asks Dom to talk about this review. [00:11:21] From a patient advocacy perspective, Ken notes that the review recommends that there should be an aggressive education campaign that can arm patients with knowledge about KMT and other novel therapies. Ken asks Dom to talk about that recommendation. [00:13:15] Ken asks about the process of cutting the review from upwards of 200 pages down to around 50 pages with 49 authors. [00:15:04] Dawn mentions that Dom was part of another paper in 2024 titled “Targeting the mitochondrial stem cell connection in cancer treatment – a hybrid orthomolecular protocol.” Dawn explains that this paper looked at the mitochondrial stem cell connection theory (MSCC), which argues that cancer originates from chronic oxidative phosphorylation insufficiency in stem cells. This insufficiency leads to the formation of cancer stem cells and abnormal energy metabolism ultimately resulting in malignancy. There were 16 research centers and organizations involved in this paper which introduced a hybrid orthomolecular protocol to target the mitochondrial stem-cell connection. Dawn asks Dom to give an overview of MSCC. [00:18:26] Dawn explains that in this paper Dom and his co-authors propose a protocol that would enhance oxidative phosphorylation and inhibit the primary fuels of cancer, glucose and glutamine. This would target both cancer stem cells and metastasis. Dawn asks Dom to explain why this concept is attracting so much interest as a potential therapeutic approach for cancer. [00:20:48] Dawn asks if Dom could discuss the orthomolecular protocol, which is an approach that focuses on preventing and treating diseases by correcting nutritional balances in the body. [00:24:41] Ken asks if the proposed dietary intervention in the orthomolecular approach is different from a standard or typical ketogenic diet. [00:26:48] Ken shifts the discussion to talk about ketone supplements, explaining that Dom recently published a paper titled “Divergent hepatic outcomes of chronic ketone supplementation.” Ken goes on to explain that ketone salts preserve liver health, while some ketone esters and precursors appear to drive inflammation and steatosis. There is a lot of interest in ketone supplementation because they substantially elevate circulating ketones without having to restrict carbohydrates as strictly. The problem, as Ken explains, is that the long-term hepatic safety of ketone supplements remains unclear. In the aforementioned paper, Dom's rodent study evaluated the formulation-dependent impact of chronic ketone supplementation on liver histopathology, inflammatory signaling and systemic biomarkers. Ken asks Dom to discuss this paper and its findings and to give an overview of the various ketone supplements currently available. [00:30:49] Dawn asks Dom to dive into the methods and findings of the rodent study. [00:34:36] Ken asks Dom what his confidence is in the rodent model used in this study, and what are the next step for further research. [00:37:47] Regarding the two different doses given to rats in the study, Ken asks Dom how these doses correlate to doses in humans [00:40:23] Ken mentions that Ben Bikman, who was our guest on episode 143, published a study in February which Dom helped co-author. It examined the effects of ketone supplements on liver function. Ken asks Dom to discuss this study. [00:44:38] Dawn pivots to ask about a joint paper that Dom did with Andrew Koutnik, who was our guest on episode 185, on carbohydrates and physical performance titled “Carbohydrate ingestion on exercise metabolism and physical performance.” Dawn asks Dom to talk about this paper, which showed that a small amount of carbohydrates is sufficient to fuel athletic performance, and how additional carbohydrate intake showed diminishing returns. [00:49:18] Ken follows up on the finding that endurance athletes who rely on carb loading can tend toward pre-diabetes. [00:51:39] Ken asks Dom about the University of South Florida trial that Dom is an advisor for on traumatic brain injury and hyperbaric oxygen therapy. [00:54:41] Dawn mentions that Dom recently had an editorial in Frontiers that gave an overview of the emerging applications of hyperbaric/hyperbaric-oxygen therapy in the treatment of different neurological disorders. Dawn asks Dom what the key points in that editorial were. [00:59:06] Dawn explains that Dom recently gave a lecture at IHMC (available to view on IHMC's YouTube page), on traumatic brain injury and the populations at greatest risk in that context. Dawn asks Dom to give an overview of how an injury to the brain can result in neurometabolic crisis. [01:02:53] Ken asks Dom, excluding occupation demographics, what demographic is most at risk for traumatic brain injury (TBI) and why. [01:04:45] Ken mentions that it is understandable the risk that young people face with TBI due to the activities that young people engage in. Older people, however, have increased risk of TBI from falling as well as an additional age-related biological component that young people are not subject to. Ken asks Dom to elaborate on this. [01:07:12] Dawn mentions that several years ago, Dom and his wife bought some acreage in the countryside and started farming and asks Dom how the farm life is going. [01:07:57] Dawn closes the interview asking how Dom's wife is doing.

In this episode the guys break down diet breaks — what they actually are, how they differ from just going off your diet, and why the science supports using them on any fat loss plan. They cover the five key benefits backed by studies: slowing metabolic adaptation, improving workout recovery and energy, preserving muscle, reducing mental fatigue, and why planning is everything. They also make the case for why most people shouldn't try to navigate diet breaks alone and how a coach changes the outcome entirely. 50% off Nutrition Coaching Call — ⁠https://mindpumpnutrition.com⁠ Code: POD50 SPONSORS Seed Daily Synbiotic — ⁠https://seed.com/mindpump⁠ Code: 25MINDPUMP — 25% off first month MAPS Summer Sale — ⁠https://mapsfitnessproducts.com⁠ Code: SUMMER40 — 40% off everything (programs, bundles & mods) — June 1–14 only LINKS Mind Pump Store: ⁠https://mindpumpstore.com⁠ Maps Fitness Products: ⁠https://mapsfitnessproducts.com⁠ Instagram: @mindpumpmedia   SPOTIFY TIMESTAMPS 0:00 - Intro 1:48 - What is a diet break? (And what it's not) 4:28 - Benefit #1: Metabolic adaptation — why your metabolism stops responding and how diet breaks help 10:29 - Benefit #2: Workout recovery and energy — why deficits kill performance and diet breaks fix it 12:27 - Benefit #3: Muscle preservation — what the data shows about fat loss vs. muscle loss 15:05 - Benefit #4: Mental fatigue — the number one reason diets fail long term 18:25 - Benefit #5: Why you must plan it — and why doing it alone usually goes off the rails 23:33 - 50% off nutrition call with a Mind Pump coach — mindpumpnutrition.com code POD50

Have you ever wondered how to enjoy your favorite carbohydrates without completely ruining your fat-loss progress or crashing your energy levels halfway through the day? This episode compiles previous interviews regarding how to fuel the body, burn fat, and use carbohydrates. Rachel Gregory shares her transition from keto to reintroducing carbohydrates to fuel training and performance. Robert Sikes explains how adherence to keto develops metabolic machinery. I share my framework on carb back-loading to manage glycogen stores. Consuming carbohydrates post-workout and at dinner keeps blood sugar from spiking, maintains fat adaptation, and shifts the body into a rest state. Keeping carbohydrates under 100 grams lets you utilize fat for energy during the day and use carbohydrates for recovery. Key takeaways Metabolic flexibility allows your body to burn fat for energy during low-impact activities and seamlessly switch to burning carbohydrates during workouts. Becoming fat-adapted typically requires a minimum of three to four weeks in a low-carbohydrate state. Reintroducing carbohydrates should be done slowly, prioritizing sources like potatoes, rice, and fruits over processed foods. Carb back-loading involves eating your carbohydrates post-workout and at dinner to replenish muscle glycogen without storing it as fat. Consuming carbohydrates in the evening helps transition the nervous system into a parasympathetic, rest-and-digest state for sleep. Strict adherence to a single dietary protocol like keto can maximize the efficiency of your body's metabolic machinery. A low-carbohydrate lifestyle can be defined as consuming under 100 grams of carbohydrates per day. Resources Website: https://milliondollarbodylabs.com/ Book: The Million Dollar Body Method by Nate Palmer Lean Energy Stack: https://milliondollarbodylabs.com/pages/lean Instagram: @_milliondollarbody