Podcasts about metabolic

In this episode, I talk with Dr. Tommy Wood about how to protect and strengthen brain health across the lifespan—how overstimulation, chronic stress, and not giving your brain time to rest and recover undermines focus and productivity, and why restructuring your workday, prioritizing sleep, and building in real cognitive breaks can help you think more clearly and perform better. We discuss how the balance of stimulus, supply, and support shifts as we age, why retirement and prolonged illness can accelerate cognitive decline without ongoing challenge, and how physical activity, deep work, and continued learning help maintain function and even build “crystallized intelligence”—wisdom—later in life. We also get into genetic risk and why it’s largely a probability game where lifestyle can stack the deck in your favor; the powerful role of social connection and helping others in reducing dementia risk; how to use digital tools for real connection instead of passive consumption; and the cognitive effects of substances like nicotine, alcohol, cannabis, and stimulants. Dr. Tommy shares practical strategies—from structuring your day around focused work and restorative breaks to picking hobbies that challenge your brain—as well as simple ways to maintain cognitive function, extend the time you stay sharp, and lower the likelihood of decline over your life. TIMESTAMPS: Tommy Wood's new book explains the environmental impact on your brain health. [01:07] In adults over 40, dementia is the number one health concern. [07:21] Why haven't we done a better job of understanding the brain's neurological disease? [13:28] Studies have shown that an older adult learning a new language or musical instrument, experiences significant changes in the structure of the brain. [20:45] Failure is the primary driver of neuroplasticity. [21:35] If you do one of two activities such as attending lectures, writing, classes, volunteering, sports and such, you are best protected from dementia. [ 26:00] What are the three S's that are the key to long-term brain health and disease prevention? [29:08] Metabolic disease like high blood pressure is a significant risk factor for dementia. [35:13] People who are stressed usually don't give their brain time to recover. [36:03] Some people do have genetic influence and possibly have a higher risk that they can learn to work with. [38:33] It's estimated that 45 to 70 ish percent of dementias are preventable. [39:53] We can eliminate this accelerated decline that we are seeing around us by hitting the checkpoints like move, nourish, stimulate, connect and adapt. [47:06] The social connection is terribly important. [47:43] The areas of the brain that are most susceptible to decreases in function as we age, are the areas of the brain that are negatively impacted by being socially isolated. [51:27] What is the impact of the digital world that surrounds us? What about smoking and alcohol? [52:26] Marijuana use definitely has an effect on brain. [01:02:46] If someone only has a small amount of time to learn these things, what would be the tips you would give them? [01:07:34] LINKS: Brad Kearns.com BradNutrition.com - 20% OFF Your First Order! B.rad Superdrink – Hydrates 28% Faster than Water—Creatine-Charged Hydration for Next-Level Power, Focus, and Recovery B.rad Whey Protein Superfuel - The Best Protein on The Planet! Brad’s Shopping Page BornToWalkBook.com B.rad Podcast – All Episodes Peluva Five-Toe Minimalist Shoes Dr. Tommy Wood Instagram @drtommywood The Stimulated Mind: Future-proof your Brain Podcast with Wood: Metabolic Efficiency Podcast with Wood: Sensible Healthy Living Podcast with Wood: Beauty of Not Always Optimizing Nourish Balance Thrive Dr.TommyWood.com We appreciate all feedback, and questions for Q&A shows, emailed to podcast@bradventures.com. If you have a moment, please share an episode you like with a quick text message, or leave a review on your podcast app. Thank you! Check out each of these companies because they are absolutely awesome or they wouldn’t occupy this revered space. Seriously, I won’t promote anything that I don't absolutely love and use in daily life: B.rad Nutrition: Premium quality, all-natural supplements for peak performance, recovery, and longevity; including the world's highest quality whey protein! Get 20% OFF your first order! 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ReferencesGuerra, DJ 2026. Unpublished LecturesThe Journal of Biological Chemistry 2018 293, 19001-19011 Int J Mol Sci. 2025 Apr 27;26(9):4147Cell Death & Disease 2019. v 10, Article number: 315 Hunter/Garcia/Kreutzmann. 1975 Franklin's Tower. Grateful Dead.https://open.spotify.com/track/3PgIhd4XmwtmV2XGU5qhzZ?si=7714f01313ca477bTravis, M. 1946. !6 Tons. Tennessee Ernie Fordhttps://open.spotify.com/track/3P6OwCX7Ofiaaqtvujb6i5?si=4b8704749b6e4390

Dr. Frank Dumont is Executive Medical Director at Virta Health, where he leads medical strategy to advance safe, scalable metabolic care. A longtime internal medicine physician at Estes Park Medical Center, he previously directed its Wellness Service Line. A Fellow of the American College of Physicians, Dr. Dumont has also served in leadership roles with the Colorado Medical Society and the American Medical Association. In this episode, Drs. Brian and Frank talk about… (00:00) Intro (04:03) How Dr. Frank's personal health issues and professional experiences as a doctor led him to adopt a metabolic health approach to healing himself and his patients (10:41) Exercise, nutrition, and de-prescribing  (14:22) Fat adaptation and fasting (24:09) Virta's peer-reviewed publications and long-term data (30:09) The positive cascading effect on holistic health of metabolic lifestyle interventions (36:25) Social support and mental health (44:41) Dr. Frank's experience leaving a standard medical practice and becoming a metabolic health practitioner (52:22) Moral injury and physician burnout in the standard medical care system (54:05) Employe wellness and metabolic health care (01:01:01) Outro/plugs For more information, please see the links below. Thank you for listening! Links: Please consider supporting us on Patreon: https://www.lowcarbmd.com/   Dr. Frank Dumont: Virta Health: https://www.virtahealth.com/ X: https://x.com/FrankDumont Linkedin: https://www.linkedin.com/in/frank-d-dumont-46aa00b7/ Dr. Brian Lenzkes:  Website: https://arizonametabolichealth.com/ Twitter: https://twitter.com/BrianLenzkes?ref_src=twsrc^google|twcamp^serp|twgr^author Dr. Tro Kalayjian:  Website: https://toward.health Twitter: https://twitter.com/DoctorTro IG: https://www.instagram.com/doctortro/ Toward Health App Join a growing community of individuals who are improving their metabolic health; together.  Get started at your own pace with a self-guided curriculum developed by Dr. Tro and his care team, community chat, weekly meetings, courses, challenges, message boards and more.  Apple: https://apps.apple.com/us/app/doctor-tro/id1588693888  Google: https://play.google.com/store/apps/details?id=uk.co.disciplemedia.doctortro&hl=en_US&gl=US Learn more: https://toward.health/community/

Every single week in my clinic, I see smart, motivated people stuck in their weight loss journey not because they're doing something wrong, but because they believe something wrong. The myths surrounding weight loss are so deeply embedded in our culture that even some physicians still repeat them. And the cost? Shame, delayed treatment, and people giving up on themselves unnecessarily. I've spent over a decade watching these myths do real damage and I'm done staying quiet about it. In this episode, I'm breaking down the top 5 weight loss myths I wish my patients would stop believing and replacing them with what the science actually says. If you've ever said "I just need more willpower" this episode is for you. Listen now!   Episode Highlights: Why "calories in, calories out" is an oversimplification of a complex metabolic system How metabolic adaptation explains why what worked before stops working Why obesity is a chronic, relapsing disease  The truth about weight loss medications and why using them is NOT cheating Why the scale is just data, not a report card, and what metabolic progress really looks like Why stopping everything after weight loss leads to weight regain, and what to do instead   Connect with Dr. Alicia Shelly: Website | drshellymd.com Facebook | www.facebook.com/drshellymd Instagram | @drshellymd Linked In | www.linkedin.com/in/drshellymd Twitter | @drshellymd   About Dr. Alicia Shelly Dr. Alicia Shelly was raised in Atlanta, GA. She received her Doctorate of Medicine from Case Western Reserve University School of Medicine in Cleveland, OH.  Dr. Shelly has been practicing Primary Care and Obesity medicine since 2014.  In 2017, she became a Diplomat of the American Board of Obesity Medicine. She is the lead physician at the Wellstar Medical Center Douglasville. She started a weekly podcast & Youtube channel entitled Back on Track: Achieving Healthy Weight loss,  where she discusses how to get on track and stay on track with your weight loss journey. She has spoken for numerous local and national organizations, including the Obesity Medicine Association, and the Georgia Chapter of the American Society of Metabolic and Bariatric Surgeons. She has been featured on CNN, Fox 5 News, Bruce St. James Radio show, Upscale magazine, and Shape.com. She was named an honoree of the 2021 Atlanta Business Chronicle's 40 under 40 award. She also is a collaborating author for the, "Made for More: Physician Entrepreneurs who Live Life and Practice Medicine on their own terms''.   Resources: FREE! Discover the 5 Reasons Your Weight-Loss Journey Has Gotten Derailed (And How To Get Back On Track!)

In this episode Andrea Samadi interviews Thoryn Stevens, CEO and founder of Brain.One, about using AI, wearables, biomarkers and evidence-based micro-habits to create personalized brain-health protocols. Watch our full interview on YouTube here https://www.youtube.com/watch?v=r9UN9kev2CE or listen and follow the show notes here https://andreasamadi.podbean.com/e/can-ai-personalize-your-brain-health-inside-brainones-protocols/  What We Covered on EP 386 with Thoryn Stephens The Problem with Generic Wellness Advice Why most health advice fails to translate into sustained behavior change The gap between research findings and real-world application Why optimization must be systematic, not inspirational From Data to Daily Micro-Habits How Brain.One analyzes peer-reviewed research using AI Turning biometrics (HRV, sleep data, metabolic markers) into actionable protocols Why small, consistent micro-habits compound into long-term neuroplastic change Wearables & What Actually Matters The most misunderstood wearable metrics HRV, sleep architecture, and recovery as early indicators of cognitive health How to avoid becoming obsessive with numbers while still using data intelligently Dementia Prevention & Cognitive Longevity Evidence-based strategies inspired by the Lancet dementia prevention framework Why metabolic health and inflammation play a critical role in brain aging Prevention vs. reversal: when to start optimizing brain health Biological Bottlenecks to Human Potential Stress dysregulation as a performance limiter Sleep architecture and glymphatic clearance Metabolic flexibility and mitochondrial function Why emotional regulation remains foundational to cognitive performance AI in Health: Hype vs. Evidence What makes Brain.One's system evidence-constrained How AI can scale personalized health protocols The future of data-driven behavioral optimization

Nearly 90% of Americans suffer from metabolic disease, Manu Diwakar tells us, citing a recent McKinsey & Company study. For Diwakar, CFO of Virta Health, that statistic defines both the scale of the challenge and the clarity of the mission.Metabolic disease, he explains, includes type 2 diabetes, obesity, liver disease, kidney disease, heart disease, and high blood pressure—“branches of a tree,” he tells us, all sharing the same root cause: poor nutrition. Virta's model blends medical professionals and technology to reverse those conditions, partnering with insurers, employers, and government entities in a B2B2C framework.From a finance perspective, the impact is measurable. Diwakar tells us Virta uses pharmacy and medical claims data to compare enrolled members with non-enrolled employees who share the same conditions—creating what he describes as a “really clean A/B test.” For type 2 diabetes, the company delivers a “two-to-one ROI,” he tells us, making the value proposition tangible.In a market captivated by GLP-1 drugs, the numbers sharpen further. Virta charges about $150 per month, Diwakar tells us, compared with roughly $1,000 per month list price for GLP-1s—about $500 after rebates. More important, he notes that when patients stop GLP-1s, weight often returns. By targeting the root cause—nutrition habits—Virta aims to make results sustainable and long-lasting, he tells us.For Diwakar, disciplined measurement and root-cause thinking align strategy with impact—improving health while lowering cost.

ReferencesStem Cell Res Ther. 2018 Dec 7;9:342Developmental Cell. 2024. V.59, Issue 2:211-227.e5January 22, Cell Commun Signal. 2023 Sep 19;21:244.Cell Discov 2024. 10, 71.Baker/Taylor. 1968 Passing the Time Cream WoFhttps://open.spotify.com/track/7wxd5oR50LKSTtqqJQxYSX?si=4e7a91cc8f6e463cPisendel, JG. 1717. Sonata in G Minorhttps://music.youtube.com/watch?v=beAdy0DoWEk&si=CCs2BQwfundJ65-u

Dr. Saadia Mian covers the medical dos and don'ts of fasting, tips on staying healthy while fasting, and how fasting impacts insulin resistance, fertility, testosterone, weight gain, and more!

ReferencesJ Biol Chem 2017 292: 20481.Cell Metabolism. 2018. 27.,3 p602-615.e4March 06Proc Natl Acad Sci U S A. 2010 May 8;107(21):9626–9631Proc Natl Acad Sci U S A. 2011 May 18;108(23):9466–9471Guerra,DJ. 2026. Unpublished LecturesHoward, B. 1954.Fly Me to the Moon. Sinatrahttps://open.spotify.com/track/7FXj7Qg3YorUxdrzvrcY25?si=3104a016654d4bb9Sparks, A. "Pinetop" 1935. Every Day I Have the Blues. Count Basis and Joe Williamshttps://open.spotify.com/track/1ZVV4uUYilEdZRySfKjvpx?si=62de0af91e7648f0Kaukonen, J. 1971. Third Week in Chelsea. JAhttps://open.spotify.com/track/5t5bV1HLuULF0bX1F6MfCv?si=d65795563a324df7

Fat loss stalled? Low energy? It might not be calories — it could be fatty liver. In this episode, Ben explains how fatty liver silently slows metabolism long before symptoms appear, and why it is one of the most overlooked reasons for stubborn weight gain. You'll learn: • How liquid sugar and constant snacking overload the liver• Why insulin is the real fat-storage hormone• The power of a simple 12–16 hour fasting window• How walking after meals can blunt insulin spikes by over 30 percent• Why sleep is essential for restoring liver insulin sensitivity• The truth about fruit, alcohol, and dietary fat• Why coffee can either heal or harm your liver depending on quality Ben also breaks down how to reverse fatty liver naturally with a simple 3-step protocol: remove the overload, restore insulin signaling, and support detox. Plus, he shares a free egg-based protocol designed to help you lose the last 10 pounds while improving liver health. If your metabolism feels stuck, this episode will help you understand why — and what to do about it. Share this with someone who needs it and remember to practice Vitamin G: gratitude. New customers get 20% off with code BENAZADI at https://bit.ly/4rV6vEE  FREE GUIDE: How To Lose 1 Pound Of Fat Per Day HERE - https://bit.ly/4j45Yxa

ReferencesBMC Biology2011 9:85Biomedicines 2023, 11(7), 1804Cancer Res (2011) 71 (2): 293–297Biophysics J. 2018. Volume 114, Issue 1, 9 January: 126-136Proc Natl Acad Sci U S A. 2024 Jan 4;121(2):e2311700120. Guerra, DJ. 2026. Unpublished Lectures.Aurelius Augustinus Hipponensis. St. 387 De libero arbitrio voluntatis.Hunter/Garcia. 1974. Scarlet Begoniashttps://open.spotify.com/track/3euDGpS2R0NC2Xssqxohva?si=1985f2fff9f146d6Simon, P. 1969. The Boxer, S&G.BoTWhttps://open.spotify.com/track/76TZCvJ8GitQ2FA1q5dKu0?si=5e15f1cdf43a4083

This episode explores tadalafil (Cialis) as a potential longevity drug, though no randomized human trials prove it extends lifespan. Cialis works by blocking PDE5, enhancing nitric oxide signaling, and improving blood flow through vasodilation. Originally approved for pulmonary hypertension, it's also used for erectile dysfunction and BPH. Its 36-hour half-life makes it superior to Viagra for continuous longevity effects.   The host frames vascular aging and endothelial dysfunction as key drivers of age-related diseases (heart disease, stroke, dementia, kidney disease). Observational data shows Cialis users have 44% lower mortality, fewer cardiovascular events, reduced dementia risk, and lower mortality in diabetics. Additional benefits include improved cardiac function, reduced infarct size, arrhythmia suppression, and regression of left ventricular hypertrophy. A 2024 meta-analysis found it lowers hemoglobin A1C, possibly via improved microvascular perfusion, insulin sensitivity, and mitochondrial function.   Cialis crosses the blood-brain barrier and may improve neurovascular coupling and hippocampal plasticity, potentially benefiting those with or at risk of dementia. Safety is generally good with long-term daily use (2.5–5 mg), though cautions include avoiding use with nitrates, low blood pressure, or certain retinal disorders. Common side effects are headache, nasal congestion, and acid reflux. The host recommends consulting a doctor and references potential synergy with telmisartan.   Tadalafil (Cialis) — MedlinePlus drug info: [https://medlineplus.gov/druginfo/meds/a604008.html](https://medlineplus.gov/druginfo/meds/a604008.html) Sildenafil (Viagra) — MedlinePlus drug info: [https://medlineplus.gov/druginfo/meds/a699015.html](https://medlineplus.gov/druginfo/meds/a699015.html)   Key mechanisms mentioned Nitric Oxide (NO) — NCBI Bookshelf: [https://www.ncbi.nlm.nih.gov/books/NBK554485/](https://www.ncbi.nlm.nih.gov/books/NBK554485/) Cyclic GMP (cGMP) — NCBI Bookshelf: [https://www.ncbi.nlm.nih.gov/books/NBK542234/](https://www.ncbi.nlm.nih.gov/books/NBK542234/)   Conditions mentioned in the episode Benign Prostatic Hyperplasia (BPH) — MedlinePlus: [https://medlineplus.gov/benignprostatichyperplasia.html](https://medlineplus.gov/benignprostatichyperplasia.html) Pulmonary Arterial Hypertension (PAH) — MedlinePlus: [https://medlineplus.gov/pulmonaryhypertension.html](https://medlineplus.gov/pulmonaryhypertension.html)   Blood pressure drug mentioned Telmisartan — MedlinePlus drug info: [https://medlineplus.gov/druginfo/meds/a601249.html](https://medlineplus.gov/druginfo/meds/a601249.html)   Other longevity / comparison drugs mentioned Metformin — MedlinePlus drug info: [https://medlineplus.gov/druginfo/meds/a696005.html](https://medlineplus.gov/druginfo/meds/a696005.html) Sirolimus (Rapamycin) — MedlinePlus drug info: [https://medlineplus.gov/druginfo/meds/a602026.html](https://medlineplus.gov/druginfo/meds/a602026.html)   Side-effect helper mentioned Ibuprofen (Advil) — MedlinePlus drug info: [https://medlineplus.gov/druginfo/meds/a682159.html](https://medlineplus.gov/druginfo/meds/a682159.html)   Dementia meds mentioned Donepezil (Aricept) — MedlinePlus drug info: [https://medlineplus.gov/druginfo/meds/a697032.html](https://medlineplus.gov/druginfo/meds/a697032.html) Amantadine — MedlinePlus drug info: [https://medlineplus.gov/druginfo/meds/a682064.html](https://medlineplus.gov/druginfo/meds/a682064.html)   Lab markers mentioned Hemoglobin A1C (HbA1c) test — MedlinePlus lab test: [https://medlineplus.gov/lab-tests/hemoglobin-a1c-hba1c-test/](https://medlineplus.gov/lab-tests/hemoglobin-a1c-hba1c-test/) Insulin in blood test — MedlinePlus lab test: [https://medlineplus.gov/lab-tests/insulin-in-blood/](https://medlineplus.gov/lab-tests/insulin-in-blood/)   People referenced (where the claims were mentioned) Huberman Lab (Dr. Andrew Huberman) — site: [https://www.hubermanlab.com/](https://www.hubermanlab.com/) Clip about low-dose tadalafil (2.5–5mg) — X post: [https://x.com/tbpn/status/2022350426394534334](https://x.com/tbpn/status/2022350426394534334) Bryan Johnson (Blueprint) — site: [https://blueprint.bryanjohnson.com/](https://blueprint.bryanjohnson.com/) Dr. David Sinclair (Harvard profile) — site: [https://sinclair.hms.harvard.edu/people/david-sinclair](https://sinclair.hms.harvard.edu/people/david-sinclair)   Show Notes   00:00 Welcome to the Hart2Heart Podcast. 01:56 What Cialis Is: PDE5 Inhibition, cGMP & Nitric Oxide Explained 03:43 Approved Uses & Origin Story: Pulmonary Hypertension, ED, and BPH 05:33 Why Cialis Over Viagra: 36-Hour Half-Life & 24/7 Vascular Benefits 06:52 Vascular Aging 101: Endothelium, Perfusion, and Why It Drives Disease 11:14 What the Human Data Shows: Observational Evidence for Mortality, CVD & Dementia 13:04 Mechanisms Deep Dive: Heart Protection, Heart Failure, and Anti-Atherosclerosis 15:02 Cialis for Diabetics: Lowering A1C and Improving Insulin Sensitivity 16:21 Brain Effects: Blood–Brain Barrier, Neurovascular Coupling & Dementia Potential 18:21 Safety, Who Should Avoid It, and Daily Longevity Dosing (2.5–5 mg) + Wrap-Up   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.   Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

In Part 2 of this conversation, we're clarifying an important distinction: chronic undereating that leads to biological binge responses is not the same as biblical gluttony.Gluttony is a heart issue — replacing our need for God with food.But many women are not struggling because they love food too much.They're struggling because they've been under-fueling their bodies for years.In this episode, Rachel unpacks:The difference between gluttony and biological survival responsesWhat chronic calorie restriction does to hormones and metabolismWhy restriction often backfires for fat lossWhat reverse dieting is and how it worksWhy slowly increasing calories can restore metabolic trustHow maintenance phases actually support long-term fat lossWhy reverse dieting can be a worshipful act of stewardshipIf you've believed the lie that you must restrict forever to see results, this episode will reframe everything.What You'll LearnWhy gluttony and biological binge cycles are not the same thingHow leptin, ghrelin, cortisol, and thyroid hormones respond to chronic dietingSigns your metabolism may be suppressedWhy eating more strategically can reduce binge urgesHow reverse dieting increases metabolic capacityWhy maintenance is not failure — it's foundationalHow to cycle between maintenance and deficit wiselyScripture Referenced1 Corinthians 6:19–20“Do you not know that your body is a temple of the Holy Spirit within you… You are not your own, for you were bought with a price. So glorify God in your body.”Ready for Structure?If this episode resonated with you, Rachel's next FASTer Way round is open. Inside, women learn how to:Reverse diet safely (when appropriate)Support metabolism and hormonesUse carb cycling strategicallyStrength train effectivelyCycle between maintenance and fat loss phasesSteward their bodies with wisdom and faithDoors are open now.I am always love to connect with you!Don't hesitate to reach out!Personal Instagram: @racheljmitchellPodcast Instagram: @livingonmissionpodEmail: rachel@racheljmitchell.comJoin my 21 Day Metabolic Reset

Welcome to Resiliency Radio with Dr. Jill Carnahan, where today's episode uncovers a critical and often overlooked driver of chronic symptoms in women: meta-inflammation. Dr. Jill is joined by Dr. Lara Zakaria, widely known as The Foodie Farmacist, for a practical, empowering conversation on how inflammation, metabolism, stress, and lifestyle intersect in women's health. In this episode, Dr. Jill Carnahan and Dr. Lara Zakaria explore why so many women feel exhausted, inflamed, and burned out—despite doing "all the right things." Drawing from Dr. Zakaria's journey from retail pharmacy to functional and personalized nutrition, this conversation reveals why addressing root causes—not just symptoms—is essential for long-term resilience. This episode is for women who want clarity, sustainable strategies, and permission to stop striving for perfection while still supporting deep healing. ✨ Like, subscribe, and share to help more women reclaim energy, balance, and metabolic health.

References Oncogene 2019. February 38(8)J Cell Mol Med. 2015 Jul; 19(7):1427–1440. J Cell Mol Med 2014 Oct;18(10):1927-37. Langmuir, 2018, 34 (1), pp 530–539Cancer Res (2011) 71 (2): 293–297BMC Biology2011. 9:85Paganini, N 1826 and 1830 Violin concerti 3 in E Major MS 50 & 4. in D minor, MS 60https://music.youtube.com/playlist?list=OLAK5uy_nzsMMijsYXkkGukLlhJjs-RngqpJekOdU&si=6Aide_5wbvs3CzkE

➡️ Get the full episode breakdown at Biology of Trauma® Podcast -  Episode 161: Dopamine and Depression: The Metabolic Link You Need to KnowDopamine doesn't just create pleasure. It signals unexpected experiences and primes the brain to learn. New research reveals that depression, anxiety, and ADHD have different metabolic phenotypes. Understanding your unique metabolic footprint explains why standard treatments work for some and not others. Mental health and metabolic health are inseparable.In This Episode You'll Learn:[01:00] How does peripheral nerve stimulation affect dopamine in the brain?[06:30] Does dopamine actually make you feel good?[13:00] What is the real function of dopamine in learning and memory?[15:30] How does trauma change the way we perceive reality?[22:00] What are metabolic phenotypes in mental health conditions?[27:00] Why does the same diagnosis look different in different people?[33:00] How are metabolism, hormones, and mental health connected?[37:00] What role does the hypothalamus play in emotional and metabolic regulation?[44:00] Why do negative experiences affect us more than positive ones?[47:00] What does anchoring to something unchangeable mean for recovery?Resources/Guides:Learn more about Dr. Kyle Bills' ResearchThe NeuroNova Seat: Dopamine-releasing neuromodulation device.Year-long Biology of Trauma® immersion program with coursework on stress, grief, attachment, letting go, freeze, and neuroplasticity. Available for self-help individuals and practitioners seeking certification.Foundational Journey — Six weeks to clean up your internal environment so repair becomes possible. This is where we create the conditions for cellular healing. Prerequisite for the Year of Transformation program.The Biology of Trauma book — Get your copy hereRelated Podcast Episodes:Episode 5: How Genetics & Epigenetics Affect In-Utero Development (Part 1) with Dr. William Walsh Episode 6: The Role of Methylation & Epigenetics in Mental Health Outcomes (Part 2) with William Walsh

Send a textIn episode #174 we discussed Dr. Jose Areta's latest research, including:How energy deficits influence muscle protein synthesis and qualityThe role of mitochondrial proteins and their upregulation during energy restrictionPractical implications for timing and periodization of caloric deficits in training cyclesHormonal signals and their interaction with muscle adaptation during energy deficitsAssociate Professor Dr. José L. Areta is a leading scholar in Exercise Metabolism and Nutrition in the School of Sport and Exercise Sciences at Liverpool John Moores University (LJMU). His research investigates how nutrition and exercise interact to influence both performance and health. He focuses on the timing and composition of macronutrients — carbohydrates, proteins, and fats — and how they affect training adaptation. José also examines the role of dietary supplements in optimizing athletic performance, as well as the endocrine and metabolic consequences of energy restriction, particularly low energy availability. He has contributed influential studies on how severe calorie deficits combined with exercise can alter muscle quality and metabolism. José's work links cellular-level changes in muscle to practical nutrition strategies for athletes facing weight-sensitive sports or energy restriction.Please note that this podcast is created strictly for educational purposes and should never be used for medical diagnosis or treatment.Follow Jose Areta's research: Study discussed, Endocrine, Metabolic, and Skeletal Muscle Proteomic Responses During Energy Deficit With Concomitant Aerobic Exercise in Humans: https://faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202502384RRIG: https://www.instagram.com/jose_l_aretaWeb: https://profiles.ljmu.ac.uk/13460-jose-aretaResearch: https://scholar.google.com/citations?user=8tP0vzUAAAAJ&hl=enMentioned:A Systematic Review and Meta-Analysis on the Association and Differences between Aerobic Threshold and Pint of Optimal Fat OxidationCreatineBeta-alanineMORE NR Save 10% on our website with code NEWPOD10 Apply to work with us, click here: https://nutritional-revolution.com/ Interested in having your biomarkers or nutrigenomics checked? Email us at nutritionalrev@gmail.com Follow us @nutritionalrevolution Save 20% on supplements at our trusted online source: https://us.fullscript.com/welcome/kchannell Join Nutritional Revolution's The Feed Club to get $20 off with an additional $20 Feed credit drop every 90 days.: https://thefeed.com/teams/nutritional-revolution If you're interested in sponsoring Nutritional Revolution Podcast, shoot us an email at nutritionalrev@gmail.com.

ReferencesCell 2011 Volume 146, Issue 3, 5 August Pages 408-420Biochim Biophys Acta. 2011 Jun;1811(6):377-85Cells. 2024 May 3;13(9):781. Page/Plant 1971. When the Levee Breaks LZ IVhttps://open.spotify.com/track/7psfcbjfnXwYIezHstNa1a?si=3b2a11090a494510Van Heusen, J /Cahn,S. 1964. My Kind of Town. Sinatrahttps://open.spotify.com/track/6jnmiFauoWEtg5yXLJYzzF?si=e84563bcb19d45fd

A systems-level exploration of methylmalonic aciduria using personalized genome-scale metabolic models. Featuring Almut Heinken, Vito Zanotelli, and Jean-Louis Guéant, discussing fibroblast transcriptomics, TCA cycle anaplerosis, heme biosynthesis flux, and the promise of multi-omics-guided precision medicine.

You're doing all the right things—showing up to the gym, getting your steps in, strength training—but that scale? Still not moving. Sound familiar? In this episode, I'm breaking down exactly how to eat to support your workouts without sabotaging your weight loss goals—and without overthinking it. No sports nutrition degree required, I promise. I've seen too many patients work incredibly hard in the gym only to undo their progress at the kitchen table. Exercise is powerful, but nutrition determines whether that exercise actually works for weight loss. And once you understand a few simple principles about pre- and post-workout nutrition, everything clicks into place. Learn why exercise alone doesn't guarantee weight loss, which common myths are holding you back, and how to fuel strategically for recovery and results.   Sign up for the Back on Track: Setting the Vision for your health Masterclass:  https://drshellymd.kit.com/ecc62a0638   Episode Highlights: Why exercise is powerful but nutrition determines whether it works for weight loss The truth about eating before and after workouts  Pre-workout fuel: when you need it, when you don't, and what actually works Post-workout recovery: protein targets, hydration basics, and avoiding the "reward" trap Special considerations for insulin resistance, PCOS, perimenopause, and GLP-1 users How to match your food to your workout type and intensity   Connect with Dr. Alicia Shelly: Website | drshellymd.com Facebook | www.facebook.com/drshellymd Instagram | @drshellymd Linked In | www.linkedin.com/in/drshellymd Twitter | @drshellymd   About Dr. Alicia Shelly Dr. Alicia Shelly was raised in Atlanta, GA. She received her Doctorate of Medicine from Case Western Reserve University School of Medicine in Cleveland, OH.  Dr. Shelly has been practicing Primary Care and Obesity medicine since 2014.  In 2017, she became a Diplomat of the American Board of Obesity Medicine. She is the lead physician at the Wellstar Medical Center Douglasville. She started a weekly podcast & Youtube channel entitled Back on Track: Achieving Healthy Weight loss,  where she discusses how to get on track and stay on track with your weight loss journey. She has spoken for numerous local and national organizations, including the Obesity Medicine Association, and the Georgia Chapter of the American Society of Metabolic and Bariatric Surgeons. She has been featured on CNN, Fox 5 News, Bruce St. James Radio show, Upscale magazine, and Shape.com. She was named an honoree of the 2021 Atlanta Business Chronicle's 40 under 40 award. She also is a collaborating author for the, "Made for More: Physician Entrepreneurs who Live Life and Practice Medicine on their own terms''.   Resources: FREE! Discover the 5 Reasons Your Weight-Loss Journey Has Gotten Derailed (And How To Get Back On Track!)

Dr. Eric Plaisance explains how exogenous ketones may provide fasting benefits without dietary restriction - the hormetic effects of mimicking starvation while fed. Plus: ketone salts vs esters, his personal protocol, and why performance claims don't hold up.Dr. Eric Plaisance, Associate Professor at University of Alabama Birmingham, has spent over a decade studying exogenous ketone esters. His most intriguing finding? Ketones may allow us to "mimic a starvation environment when we're not starving" - potentially triggering the same hormetic benefits as fasting without dietary restriction. In this conversation, we explore the anti-inflammatory effects of ketones, the promising research in liver health and cancer, and the practical differences between ketone salts, esters, and MCT oil. Dr. Plaisance shares his personal ketone protocol (including why he takes them before workouts during time-restricted eating), optimal dosing strategies, and why the athletic performance marketing claims don't match the research. We also discuss who should actually consider ketone supplementation versus who should save their money. A grounded, evidence-based perspective on one of longevity's most debated supplements.

ReferencesJ Biol Chem. 2012 Nov 23;287(48):40131-9PLoS Biol 2014. 12(10): e1001969.doi:10.1371/journal. BioNature, 2019. vol. 575, no. 7783, Nov, pp. 361+.Trad. 1972. I Know You Rider Grateful Deadhttps://open.spotify.com/track/2M7u9Anw0WbTLsCIHxRoV3?si=7564411354c8414d

ReferencesGuerra, DJ. 2026. Unpublished lecturesGuerra. DJ. 2022. J of Disease and Global Health Volume 15 [Issue 3]:22-47.Essays Biochem. 2018 Jul 20;62(3):341–360J Am Chem Soc. 2025 Jul 8;147(28):24258–24274.Bach, JS 1726. Partita for Clavier in D Major BMV828https://music.youtube.com/watch?v=M3k0gSDSYPM&si=m3ANN3qws1OEI67hTelemann , GP. 1720 (?) Sonata in F Minor for trombonehttps://music.youtube.com/watch?v=cfal1EV64gs&si=ET_6TxL2xQ_vpoL6

Managing a horse diagnosed with metabolic problems means understanding how conditions such as equine metabolic syndrome (EMS) and insulin dysregulation increase the risk of serious complications, including laminitis. Horses with metabolic problems often benefit from controlled diets low in sugars and starches, tailored to prevent spikes in blood insulin and support healthy body condition. Regular exercise and weight management should be part of a comprehensive plan because activity can help improve insulin sensitivity and supports overall metabolic health. While there's no cure for these conditions, strategic, research-based care can help improve your metabolic horse's well-being.During this podcast, two experts answer listener questions about managing horses that have metabolic problems.About the Experts: Greg Schmid, DVM, originally from Canada, moved to Ohio as a teenager, where his family trained dressage and eventing horses. He earned a Bachelor of Science in equine science from Otterbein University, in Westerville, Ohio, and a DVM from The Ohio State University, in Columbus. After graduation, Schmid completed an internship at B.W. Furlong & Associates, in Oldwick, New Jersey, and then worked with Dr. John “Doc” Steele in a hunter/jumper-focused practice covering the East Coast. He later practiced in Portland, Oregon, working with various English and Western sport horses. Schmid joined Dechra as an equine professional services veterinarian in September 2020 and now lives in Asheville, North Carolina.Caitrin Lowndes, DVM, is a research fellow at the Van Eps Laminitis and Endocrinology Laboratory at the University of Pennsylvania's New Bolton Center, in Kennett Square, with a background in field practice. Her main area of research is the improved diagnosis and management of insulin dysregulation, with particular interest in how that research can be translated into clinical practice for the treatment and prevention of laminitis.

ReferencesGuerra, DJ 2026.unpublished lecturesAdv Sci (Weinh). 2024 Oct18;11(46):2404033.Kristofferson. C. 1969.Me and Bobby McGee. Grateful Deadhttps://music.youtube.com/watch?v=RqvX083cFc8&si=x7-qhXWgKFxhRFK5Dvorak, A 1893 . New World Symphony #9. in E Op. 95, B. 178https://music.youtube.com/watch?v=jOofzffyDSA&si=oPNIZAOeYhsjoiWV

In this episode, Ben Azadi explains the five metabolic levels of fat loss and why most people feel stuck despite dieting, exercising, and eating “clean.” Fat loss is not about willpower or calories. It is about hormones, inflammation, and metabolic signaling. Many people fail because they are using the wrong strategy for the metabolic level their body is currently in. Ben breaks down each level, from the Frozen Phase, where the body is in survival mode and unable to burn fat, to Fat-Burning Freedom, where fat loss becomes effortless and sustainable. You will learn: Why caloric restriction and excessive cardio backfire How insulin resistance and inflammation block fat loss Why eating clean is not enough without proper timing and protein How intermittent fasting, strength training, and recovery reset metabolism What it truly takes to lose 25–50+ pounds and keep it off This episode reframes fat loss as a metabolic progression and provides clarity for anyone who has struggled with plateaus, rebounds, or frustration on their health journey.

What if lasting energy and better health didn't require complicated routines or constant stress? In this episode, Dr. Debbie Ozment, DDS, shares her refreshingly simple approach to enhancing vitality, preventing disease, and creating sustainable wellness habits that truly work. As the host of the Vitality Made Simple podcast, Dr. Ozment focuses on early detection, prevention, and practical strategies that help people feel their best at every stage of life. With decades of experience in dentistry and integrative health, she highlights how oral health, inflammation, toxins, and emotional stress can quietly drain energy and impact long-term wellbeing — and what you can do about it. In this conversation, we explore: ·       How small, consistent lifestyle changes can extend your vitality span ·       The connection between oral health, inflammation, and chronic disease prevention ·       Simple, stress-free ways to support mental, emotional, and physical wellness Dr. Ozment has been in private dental practice since 1985 and is a graduate of the University of Oklahoma College of Dentistry. She later earned a Master's degree in Metabolic and Nutritional Medicine from the University of South Florida Morsani College of Medicine and is a Diplomate of the American Academy of Anti-Aging Medicine. Trained at the Mayo Clinic and certified as a National Board-Certified Health and Wellness Coach, she brings a truly integrative perspective to modern health. Follow Dr. Ozment on Instagram @drdebbieozment to stay up to date with her latest insights and resources. Episode also available on Apple Podcasts: https://apple.co/38oMlMr  Keep up with Debbie Ozment socials here: Facebook: https://www.facebook.com/drdebbieozment/ Youtube: https://www.youtube.com/@drdebbieozment

ReferencesDiscoveries (Craiova). 2017 Jul-Sep; 5(3): e77. Adv Sci (Weinh). 2024 Oct 18;11(46): 2404033.Guerra, DJ.2026. Unpublished Lectures Biber, HI. 1676. Violin Sonata 84 in E. c.108https://music.youtube.com/watch?v=RujpXPN4ooU&si=kth4IP6bHzHjG4HB

Welcome to "Thriving in Midlife" The Women's Guide to Wellness, Longevity & Hormones After 40. This is your trusted space to cut through the noise, ditch the overwhelm, and finally feel extraordinary in your body, mind, and life. Are you ready to stop pushing through life and start living it with intention, energy, and ease? Then let's get started. I'm your host, Kellie Lupsha, a high-performance health coach, who is delighted to be your guide to vitality.In this episode, Dr. Heidi and I dive into something we all think we understand, our energy. But the truth? There are hidden factors quietly draining it, and most of us don't even realize it. We talk about what's really happening in our bodies, how to tune in, and why feeling energized again is absolutely possible.This episode is perfect for anyone who's ever felt tired by noon, relied on coffee to survive the day, or just wants to feel like themselves again, fully energized and in control.Key Highlights:➡️ Why feeling tired for “too long” slowly becomes your new normal➡️ The difference between being lazy and being energetically drained➡️ How small changes in daily habits can make a big difference in how we feel.➡️ The role of movement in generating, not just burning energy.➡️ How our nervous systems get stuck in perpetual "go mode," even when we think we're slowing down.➡️ A sneak peek into mitochondrial health and how it affects vitality as we age.➡️ Practical tips to start taking control of your energy today, without drastic changes.Key Takeaways:"Energy isn't something that you chase. You have to build this in your body. You have to create this by what you're doing..." - Kellie Lupsha"Sometimes we feel lazy and it's not laziness, you're drained... It's not your lack of willpower or poor push through... you can regenerate your energy again because there's very some key things that you can do to address that." - Dr. Heidi*TAKE THE FREE ~ DISCOVER YOUR MIDLIFE HEALTH BLUEPRINT*****>>> Click Here

Amanda King  After earning her BSc through the Open University that combined Human Biology with Psychology and Counselling, Amanda King advanced her clinical training through the College of Naturopathic Medicine in London, qualifying as a Nutritional Therapist in 2022 and as a Naturopathic Practitioner in 2024. Most recently, she completed the Practitioner Master Course in Integrative Metabolic Oncology with the Metabolic Terrain Institute of Health under Dr Nasha Winters, further deepening her expertise in terrain-focused cancer care. Over the past decade, Amanda has honed her practice at the intersection of nutrigenomics, methylation science and epigenetics, integrating advanced lab diagnostics with personalised nutrition, therapeutic ketogenic and ancestral diets, and targeted supplementation to optimise each patient's metabolic landscape. A certified nutrigenomics practitioner with training in Integrative and Gestalt psychotherapy , she is widely regarded for translating complex genomic and hormonal data such as DNA methylation panels and DUTCH hormone testing into pragmatic nutrition and lifestyle protocols that address both biochemical individuality and psychological wellbeing. In her integrative oncology nutrition practice, Amanda delivers bespoke protocols that weave together diet, lifestyle optimisation, mindset coaching and evidence-based complementary therapies, empowering patients to navigate cancer with clarity and agency. Committed to reshaping the dialogue around food as medicine, she collaborates with metabolic oncologists, functional laboratories and patient-advocacy groups worldwide to expand access to precision, nutrition-centred oncology care and to generate rigorous outcome data that will elevate the standard of integrative cancer support. Link to Show Notes on Website https://fabulouslyketo.com/podcast/255 Amanda’s Top Tips Use the tools available to support you e.g. keto monitors, trackers, CGMs, food tracking apps, blood testing. Stay clean – not dirty keto – not all fats are equal. Know the difference. Manage your stress levels. Connect with Amanda King on social media Facebook Profile: https://www.facebook.com/the.metabolic.nutritionist Instagram: https://www.instagram.com/the.metabolic.nutritionist/ LinkedIn: https://www.linkedin.com/in/amandakingnd/ YouTube: https://www.youtube.com/@FabulouslyKeto Website Details: https://www.themetabolicnutritionist.com https://linktr.ee/amandakingnd The Fabulously Keto Diet & Lifestyle Journal: A 12-week journal to support new habits – Jackie Fletcher If you have enjoyed listening to this episode – Leave us a review By leaving us a review on your favourite podcast platform, you help us to be found by others. Support Jackie Help Jackie make more episodes by supporting her. If you wish to support her we have various options from one off donations to becoming a Super Fabulously Keto Podcast Supporter with coaching and support. Check out this page for lots of different ways to support the podcast. https://fabulouslyketo.com/support Or You can find us on Patreon: https://www.patreon. com/FabulouslyKeto Connect with us on social media https://www.facebook.com/FabulouslyKeto https://www.instagram.com/FabulouslyKeto1 https://twitter.com/FabulouslyKeto https://www.youtube.com/@FabulouslyKeto Facebook Group: https://www.facebook.com/groups/FabulouslyKeto Music by Bob Collum Recommend a guest We would love to know if you have a favourite guest you would like us to interview. Let us know who you would like to hear of if you have a particular topic you would like us to cover. https://fabulouslyketo.com/recommend-a-guest We sometimes get a small commission on some of the links, this goes towards the costs of producing the podcast.

Stay Connected Beyond the Podcast Subscribe to our Substack to get episode updates, event announcements, wellness tips, and personal thoughts from Marnie and Stephanie delivered straight to your inbox. If you love the show and want to support what we're building, consider a paid subscription for $30 annually. Your support helps fund podcast production and allows us to continue bringing you meaningful, high-quality conversations. https://theartoflivingwell.substack.com/ What if your symptoms weren't random — and aging didn't have to mean decline? In this in-depth and highly practical episode, we explore how understanding your unique biology, labs, and lifestyle can completely change your health trajectory. In this powerful conversation on The Art of Living Well Podcast®, hosts Marnie Dachis Marmet and Stephanie May Potter welcome back Dr. Stephen Cabral for a third time. Dr. Cabral dives deep into the principles of Personomics, root-cause healing, and why testing — not guessing — is essential for long-term health and longevity. Together, they walk through real lab results on air, explain what common imbalances actually mean, and break down why most people normalize symptoms that are early warning signs from the body. From gut health and mold exposure to neurotransmitters, stress, genetics, and aging, this episode offers clarity, reassurance, and a clear roadmap for healing. _______________________________________ What You'll Learn in This Episode: ● What Personomics is and how it differs from traditional medicine ● The difference between chronological age and biological age ● How to identify the early signs your body is out of balance ● Why most people feel "fine" but are actually compensating ● The power of functional medicine lab testing vs. guessing ● What gut, vitamin, and neurotransmitter labs can reveal ● How stress, mold, and lifestyle impact energy and resilience ● Why supplements alone don't heal — and when they do matter ● How to personalize protocols without overdoing it ● How to build a sustainable, boring routine that supports longevity _______________________________________ Noteworthy Quotes from the Episode: ● "All symptoms trace back to deficiencies or toxicities." – Dr. Stephen Cabral ● "You don't heal by adding more — you heal by removing what doesn't belong." – Dr. Stephen Cabral ● "Your genetics are real, but they are not your destiny." – Dr. Stephen Cabral ● "You never truly know what's going on until you test." – Dr. Stephen Cabral ● "Most people think they're fine because they've normalized their symptoms." – Dr. Stephen Cabral ● "There's a system to healing — it's not guesswork." – Dr. Stephen Cabral _______________________________________ Episode Breakdown with Timestamps: 00:00 - Trailer & Intro 02:15 - Why feeling "okay" is not the same as being healthy 06:00 - Deficiencies vs toxicities and why supplements fail 10:55 - The Rain Barrel Effect and stress accumulation 16:00 - Why genetics does not control your health 21:30 - The flaw in one-size-fits-all medicine 26:40 - Early body signals before chronic disease 31:00 - Why lab testing beats guessing 41:30 - Stress, dopamine, and burnout in high performers 52:30 - Longevity, anti-aging, and health after 40 _______________________________________ Wellness Resources for Everyday Health: This is the exact functional lab test discussed on the show. The Stephen Cabral Candida, Metabolic, and Vitamins Test provides insight into gut health, metabolism, and key nutrient levels. Get $150 off at stephencabral.com/livingwell  _______________________________________ Looking for a clean, plant-based boost for energy, focus, and immunity? We love ENERGYbits algae tablets—a simple, nutrient-dense superfood made from pure algae.

Most nutrition advice still treats food as fuel, calories to burn, macros to balance, energy to manage. The body doesn't experience food that way.In this foundational episode, Dr. Ritamarie explains why food is first and foremost information, a powerful metabolic signal that shapes hormones, stress responses, inflammation, and repair, before calories are ever used.You'll learn why rigid nutrition plans often fail, why the same food can produce opposite effects in different bodies, and how a nutritional endocrinology lens transforms nutrition from mechanical rules into physiological understanding.If you've ever followed a “perfect” diet and still felt stuck, or watched good food choices backfire, this episode reveals what's really happening beneath the surface.What's Inside This Episode?Why the calorie-and-macro model explains combustion, but not communicationThe signals every meal sends to insulin, cortisol, thyroid, and inflammationWhy the same food can calm one body and stress anotherHow timing, stress, and metabolic state change how food is interpretedThe real reason rigid nutrition protocols stall progressWhat it means to match food choices to the body's current prioritiesHow nutritional endocrinology teaches you to listen instead of overrideResources and Links:Download the full transcript hereDownload our FREE Functional Food Guide hereJoin the Next-Level Health Practitioner Facebook group here for free resources and community supportVisit INEMethod.com for advanced health practitioner training and tools to elevate your clinical skills and grow your practice by getting life-changing results. Check out other podcast episodes here

ReferencesCell Death & Disease 2022. volume 13, Article number: 444 Cancer Cell. 2010 Feb 18;17(3):225–234Biochem Biophys Rep. 2020 May 20;22:100769eLife. 2015 Jul 31;4:e07420. Biochemistry2013. June. 52(26)Joel, B. 1978 Honesty. https://open.spotify.com/track/34E0Higz6fFVXlbVsn6TIW?si=1fc76f8e7d514dfb Joel, B. 1974. Street life Serenader https://open.spotify.com/track/5tFUPBJqdtWjxCdBtqDwRf?si=9220f9874f214a6fJoel, B. 1977. Scenes from an Italian Restaurant.https://open.spotify.com/track/3utq2FgD1pkmIoaWfjXWAU?si=b6c0eeaa07fe4348Hunter/Garcia. 1971. Not Fade Away/Goin Down the Road Grateful Dead.https://open.spotify.com/track/3JZeVTm20lmT0wTui4oWh9?si=408821e635784759

Roughly 90% of Alzheimer's patients develop neuropsychiatric symptoms including anxiety, persistent fear, and an inability to recognize safety — but little research is being done to investigate why. New data connecting PTSD, trauma, and accelerated brain aging may hold the answer.Dr. Caesar Hernandez is a behavioral, molecular, and circuit neuroscientist and assistant professor in the Division of Gerontology, Geriatrics & Palliative Care at the University of Alabama at Birmingham. His research program seeks to identify modifiable mechanisms that drive vulnerability to age-related cognitive decline and Alzheimer's disease.In this conversation with Dr. Dominic D'Agostino, Dr. Hernandez walks through epidemiological evidence linking PTSD to increased Alzheimer's risk, the comorbidity cluster of metabolic syndrome, gut permeability, and neuropsychiatric disorders observed in veteran populations, and why ketogenic interventions may offer a unique therapeutic angle — reducing neuroinflammation and anxiety while making the brain more receptive to rewiring traumatic memories.Questions Answered in This Episode: Could addressing PTSD in midlife meaningfully reduce the risk of cognitive decline and dementia later in life?Why do veteran populations show such high comorbidity between PTSD, metabolic syndrome, and dementia? Could ketogenic therapy serve a similar function to pharmacologically-assisted psychotherapy for PTSD? How does the amygdala - the brain's "fear center" - play a role in Alzheimer's disease? What is the single biggest unanswered question driving Alzheimer's research right now — and why does it go beyond genetics and biochemistry?Dr. Hernandez's driving question — why are negative life experiences associated with an increased the risk of neurodegeneration? — reframes brain aging as something shaped not just by genes and biology, but by the lives we live and the stress we carry.Find more of Dr. Caesar Hernandez online:University of Alabama BirminghamLinkedInSpecial thanks to the sponsors of this episode:✅ Genova Connect – Get 15% off any test kit with code METABOLICLINK here.✅ Fatty15 – Get 15% off a 90-day Starter Kit with code METABOLICLINK here.✅ Troscriptions – Get 10% off your first order with code METABOLICLINK here.✅ ZocDoc - Find and instantly book a top-rated doctor here.In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel!Find us on social: Instagram Facebook YouTube LinkedIn Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.

ReferencesScientific Reports 2021 volume 11, Article number: 16512Front. Oncol.2017. 26 November Vol7.Cell Death & Disease 2022. volume 13,Article number: 444Guerra, DJ. 2026. Unpublished LecturesMozart, WA. 1784. Serenade No. 10 for winds in B-flat major, "Gran Partita," K. 361https://music.youtube.com/watch?v=k0ig72-rj0s&si=VykW0x8UnOFGq0-e

Is melasma really a skin problem—or is it your body asking for help? In this episode of The Health Detective Podcast, Detective Ev sat down with Ariana Juarez, Functional Diagnostic Nutrition Practitioner (FDN-P) and founder of Alura Wellness, to uncover the truth behind chronic hyperpigmentation and melasma. If you've tried creams, lasers, peels, or prescriptions—only to see dark patches return—this conversation explains why those approaches so often fail. Ariana breaks down melasma as a metabolic skin condition, not a cosmetic flaw. Rather than being something to “cover up” or burn away, melasma is a visible signal of deeper internal imbalance involving hormones, blood sugar regulation, inflammation, detox pathways, and nutrient status. When those drivers aren't addressed, surface-level treatments can't create lasting change. The good news? Melasma is reversible when you understand what your skin is communicating and address the root cause.  Ariana shares how her functional approach helps clients reverse melasma, slow accelerated aging, and restore skin health by supporting the body as a whole—not fighting it.     Want to watch this episode on YouTube? Click here. Subscribe if you'd like to catch all new episodes live and participate with our guests directly.   Want to learn more about becoming an FDN? Go to fdntraining.com/resources to get our best free workshops and mini-courses! Where to find Ariana Juarez: Website: alurawellness.com Instagram: @alura.wellness X: @alurawellness  

ReferencesJ Cell Biol. 2014 Mar 17;204(6):919–929Orphanet Rare Dis. 2012 Jul 9:7:46. Nature 2019. volume 575, pages 361–365Guerra, DJ.2026. Unpublished LecturesHolland/Dozier/Holland 1967. Reflections The Supremeshttps://open.spotify.com/track/4yChgYDVcQrAgIEIErW27b?si=e97ce04bbb104674McAleese. T. 1969. Reflections of My Life. The Marmaladeshttps://open.spotify.com/track/1oP7k6VKHbbISKaPM5kDjx?si=8e9ab9851adf4b4aHunter/Garcia. 1970 Ripple Grateful Dead American Beauty lphttps://open.spotify.com/track/4aQ8mFkZU6dmHaZOOKdscc?si=e08ae9928aab4028Lennon/McCartney. 1967. A day in the Life Sgt Peppers lp.https://open.spotify.com/track/0hKRSZhUGEhKU6aNSPBACZ?si=f7c366d0b377449c

Weak grip strength is not a normal part of aging. It is often an early warning sign of metabolic dysfunction. In this episode, Ben explains how issues like insulin resistance, chronic inflammation, mitochondrial decline, and mineral depletion can weaken nerve signaling and muscle function, especially in the hands. Grip strength is one of the strongest predictors of longevity, independence, and overall metabolic health. You'll learn why people can look fit yet still struggle with weak hands, cramping, or fatigue, and how these symptoms often appear years before serious disease. Ben breaks down the four main root causes behind grip weakness and shares a simple daily protocol to restore strength. The episode covers insulin resets, nutrition strategies, mineral support, protein intake, grip training, and the role of creatine in improving strength and muscle signaling. Ben also explains why chronic stress and inflammation accelerate metabolic decline and how gratitude can positively impact metabolism. This episode offers practical, actionable steps you can start today to rebuild grip strength, improve energy, and protect long-term metabolic health. CLICK To Get Your Creatine - MYOXCIENCE Use Coupon Code "FREEDOM" for 25% off - https://bit.ly/4qTgABP 

In this episode, Dr. Geo is joined by Dr. Steven Freeland to discuss the powerful intersection of urologic oncology and metabolic health. Dr. Freeland shares groundbreaking research on how dietary interventions—specifically low-carbohydrate protocols—can slow prostate cancer progression and counteract the metabolic damage caused by standard treatments like Androgen Deprivation Therapy (ADT).In This Episode, You'll Learn:The Metabolic Growth Signal: Why insulin and Insulin-like Growth Factor 1 (IGF-1) are considered "fuel" for prostate cancer cells and how reducing sugar can starve that signal.The 20-Gram Protocol: Insights from Dr. Freeland's study on ultra-low-carb diets, where participants saw a 20-pound weight loss and a significant slowing of PSA doubling time.Combatting ADT Side Effects: How a metabolic approach can improve insulin resistance by 30% and surprisingly help preserve bone density during hormone therapy.The "Slim-Fat" Reality: Why your BMI might be normal, but your visceral fat (adiposity) could still be driving inflammation and cancer growth.Clinical Markers to Watch: Why patients should ask about HOMA-IR (Insulin Resistance) and Hemoglobin A1C rather than just focusing on PSA alone.Key Quotes from the Episode:"Lifestyle intervention isn't alternative medicine; it is metabolic medicine." — Dr. Steven Freeland"Cancers need the same nutrients the body needs to grow. If we're reducing pro-growth stimuli to the whole body through weight loss and low carbs, it makes sense we're reducing it to the cancer." — Dr. Steven FreelandResources & Links Mentioned:Dr. Steven Freeland: Cedars-Sinai Faculty ProfileResearch Paper: Ultra-low carbohydrate diet and prostate cancer progression (referenced as the "20-gram study").Recommended Diet Protocol: Induction Phase Atkins (as used in the clinical trials).Clinical Markers: * HOMA-IR: (Fasting Insulin $times$ Fasting Glucose) / 405 (or 22.5 in SI units).Hemoglobin A1C: A 90-day average of blood sugar levels.Wearables: Fitbit, Oura Ring, and Whoop (discussed in the context of tracking "active steps" and sleep quality).Episode Breakdown by Timestamp:[07:35] Breaking down the 20-gram carbohydrate trial and patient adherence.[13:45] The impact of...

References Nature 2019. volume 575, pages 361–365Cells 2022, 11(21), 3339J Cell Biol. 2014 Mar 17; 204(6):919–929.Guerra, DJ 2026. Unpublished Lectures.Lennon/McCartney. 1963. Do you want to Know a Secret? Beatleshttps://open.spotify.com/track/7Aobt67JnaF7qN8jCCKvHq?si=920b5f425e7f4210Page/Plant. 1969. What is and what Should Never Be. LZ IIhttps://open.spotify.com/track/5G7uLHtoEW140QOcBpJlfz?si=e4d2b51ba7c74148Lennon/McCartney. 1966. Good Day Sunshine. Beatleshttps://open.spotify.com/track/7HTH1ppjkkOe7RLoBDKXYJ?si=1144ceb5fb7d4f56Boccherini, L. 1769. Cello Concerto in B flat Major #9.https://music.youtube.com/watch?v=IUSnRLPbZGk&si=wiRtkMzPKbGMTMjC

Yellow teeth are not just a cosmetic issue. They are often a metabolic signal linked to saliva pH, gut health, liver function, and mineral balance. Most whitening strips and bleaching products do not fix the root cause. They temporarily whiten teeth while weakening enamel, increasing porosity, disrupting the oral microbiome, and causing rebound staining over time. Teeth are porous, like a hard sponge. When saliva becomes acidic, stains bind more easily, enamel weakens faster, and whitening results do not last. Common internal drivers of yellow teeth include acid reflux or silent GERD, gut dysbiosis, liver congestion, mineral deficiencies, chronic dehydration, and inflammation. This episode breaks down a natural, root-cause whitening protocol that supports enamel instead of damaging it. Key strategies include using baking soda and activated charcoal safely once per week, oil pulling with coconut oil, and restoring saliva pH through nutrition and mineral intake. You will also learn which foods support healthy saliva pH, which foods and drinks actively damage enamel, and why frequent snacking worsens staining even with healthy foods. The core message: your smile is metabolic, not cosmetic. Fix the internal imbalance, and whitening becomes natural and long-lasting.

ReferencesPLoS One. 2014 Oct 10;9(10):e108676Cells. 2023 Jul 20;12(14):1897Guerra, DJ 2026. Unpublished LecturesLennon/McCartney, 1970 Let it Be Beatleshttps://open.spotify.com/track/7iN1s7xHE4ifF5povM6A48?si=515d845e022944e3North and Zaret, 1955. Unchained Melody Righteous Brothershttps://open.spotify.com/track/2qhASBzpbFhPRtrnZ5lLnz?si=b9c322a53dab4077

The Hume Health Body Pod is the smart health scale Nurse Doza uses daily — at home, in the clinic, and everywhere in between. With 8 multi-frequency sensors and accuracy within 2% of a DEXA scan, it measures 45+ health metrics including muscle mass, visceral fat, bone density, heart rate, and metabolic age in just 3-5 seconds. As discussed in this episode, putting real body composition data in your hands is the key to becoming your own health advocate.

Peptides. GLP-1s. Metabolic health.What's real—and what's misunderstood?In this episode, Dr. Kyle Gillett joins the show to unpack the science and clinical reality behind some of the most talked-about tools in modern medicine. We cover how GLP-1s actually work, where peptides fit in, common mistakes people make, and how lifestyle still underpins everything.This is an evidence-based conversation designed to cut through hype and give you clarity.

Waking up in the middle of the night to pee is not normal, even if it only happens once. This episode reveals why nighttime urination is an early metabolic warning sign, not a bladder or prostate issue. Ben explains how insulin resistance, blood sugar spikes, cortisol, and disrupted hormones interfere with deep sleep, fat burning, and brain detoxification. When sleep is interrupted, belly fat increases, hormones fall out of balance, and the brain's nighttime cleaning process shuts down. You'll learn the five main metabolic causes behind nighttime urination, including late-night eating, alcohol, electrolyte imbalance, high cortisol, and fluid shifts in the body. Ben also shares simple changes you can start tonight to sleep through the night again. This episode breaks down why most doctors miss this signal, how insulin resistance can exist years before diabetes, and how fixing metabolic signals can restore sleep, energy, fat loss, and long-term health. If you're waking up to pee, feeling wired but tired, or struggling with stubborn belly fat, this episode could change everything.

A McGill University study found that childhood adversity combined with altered brain insulin signaling increases metabolic disease risk in women, even before clinical signs like diabetes or heart disease appear Early stress reprograms brain regions that govern reward, impulse control, and energy balance, raising visceral fat storage and disrupting insulin sensitivity decades after the original stress occurred Women with higher brain insulin signaling activity were more vulnerable to metabolic harm from childhood stress, showing greater fat gain and a higher risk for metabolic syndrome than men Stress-related metabolic disruption often remains undetected because changes like visceral fat buildup and inflammation occur below standard clinical thresholds, delaying recognition until the disease is more advanced Reducing ongoing stress, improving insulin sensitivity, limiting linoleic acid (LA) intake, restoring energy production, and supporting hormonal balance can help counteract early stress and lower long-term metabolic risk

🧭 REBEL Rundown 📝Introduction Welcome to this special edition of the REBEL Cast, where we unravel key highlights and educational insights from the IncrEMentuM Conference in Spain. This event is a cornerstone for advancing emergency medicine education, drawing esteemed speakers and participants from around the globe. As emergency medicine gains traction in Spain, this conference has become an essential platform for knowledge exchange and professional growth. Today, host Dr. Mark Ramzy shines a spotlight on two phenomenal educators: Drs. Sara Crager and Ryan Ernst who shared their expertise and experiences at this transformative gathering last spring. Click here for Direct Download of the Podcast. 🤔What's IncrEMentuM? A new conference and a pivotal gathering for emergency medicine professionals worldwide, has become an essential platform for education, collaboration, and advocacy, especially in light of emergency medicine’s recent recognition as a specialty in Spain. The conference is praised for its outstanding production quality, engaging speakers, and its capacity to foster a global community of emergency care professionals. ️What's an Essential Question? Essential questions are open-ended, thought-provoking, and intellectually engaging inquiries that inspire deeper exploration into topics. In the context of medical education, they challenge practitioners to think critically and reflect on their practice deeply. By focusing on essential questions, medical educators aim to inculcate a culture of continuous learning and curiosity, ensuring that medical professionals stay adaptable and insightful in their approach to patient care. 🎮Rapid Sequence (no not the intubating style...)  The Rapid Sequence game is an innovative tool that Sara and Ryan designed to enhance the learning experience for emergency medicine clinicians. It mimics real-life scenarios requiring rapid decision-making in high-pressure situations, such as those faced in emergency medical settings. This clinical case-based game aims to improve cognitive and procedural skills, allowing participants to hone their ability to respond effectively under pressure, thereby enhancing their real-world clinical performance.You can try it out for free on their website here!Their work was featured in the September 2025 edition of Annals of Emergency Medicine as a 2025 ACEP Abstract 🌳The Arboretum Teaching Collective An arboretum is a space that cultivates a wide variety of diverse, unique, and symbiotic growth. Arboretum provides a creative space to decrease barriers, open opportunities, and support the development of extraordinary teachers. The Arboretum Teaching Collective is a non-profit organization dedicated to supporting emergency medicine education in countries where it is a new or evolving specialty.  Their aim to facilitate the development of expert teachers by reducing barriers, providing opportunities, and curating talent.  Their goal is to create a community of educators around the globe who share a vision of bringing excellent, innovative emergency medicine teaching to where it is most needed.  Their approach is driven by curiosity, humility, and sustainability.If you want to learn more and get involved, check out the Arboretum Teaching Collective Website Here ️ See you in Spain! The upcoming conference aims to gather world-class educators once more and promises an enriching experience for all attendees. Drs. Sara Crager and Ryan Ernst, along with many others, will be there at the event. For more information on the IncrEMentuM Conference and to register, visit their website! See you there! Sara Crager, MD Associate Professor, Critical Care and Emergency Medicine UCLA, Los Angeles, CA Ryan Ernst, MD Assistant Professor of Emergency Medicine, Section Chief of Global EM University of Utah, Salt Lake City, UT Mark Ramzy, DO Co-Editor-in-Chief Rutgers Health / RWJBH, Newark, NJ 🔎 Your Deep-Dive Starts Here REBEL CAST – IncrEMentuM26 Speaker Spotlight : Drs. Sara Crager and Ryan Ernst Host Dr. Mark Ramzy shines a spotlight on two phenomenal ... Resuscitation Read More REBEL CAST – IncrEMentuM26 Speaker Spotlight : Drs. Tarlan Hedayati, Jess Mason and Simon Carley Host Dr. Mark Ramzy shines a spotlight on three distinguished ... Resuscitation Read More REBEL CAST – IncrEMentuM26 Speaker Spotlight : George Willis and Mark Ramzy 🧭 REBEL Rundown 📝Introduction In this exciting episode of REBEL ... Endocrine, Metabolic, Fluid, and Electrolytes Read More Incrementum Conference 2026: Revolutionizing Emergency Medicine in Spain In this special episode of Rebel Cast, we spotlight the ... Read More The post REBEL CAST – IncrEMentuM26 Speaker Spotlight : Drs. Sara Crager and Ryan Ernst appeared first on REBEL EM - Emergency Medicine Blog.

Around the world, we're seeing declining sperm counts, rising infertility, more erectile dysfunction, and lower testosterone—even in younger men. These trends aren't just affecting family planning; they're pointing to something much bigger happening in men's health. Joining me today on The Dr. Hyman Show is Dr. Michael Eisenberg, a Stanford researcher and leading voice in male reproductive health. We talk about why sperm quality matters far beyond fertility—and how everyday health choices quietly shape it. Watch the full conversation on YouTube or listen wherever you get your podcasts. [YOUTUBE THUMBNAIL] We cover: • Why sperm quality may be one of the strongest early indicators of overall health and longevity • How metabolic dysfunction, belly fat, and low testosterone impact fertility and sexual function • The role environmental toxins and endocrine disruptors play in declining sperm counts • What men can do right now to protect fertility and long-term vitality When we look at fertility through the lens of whole-body health, it changes how we think about prevention, risk, and longevity. Male fertility isn't just about reproduction. It's a signal. Register for The Ultra Learning Series: Functional Fertility on Thursday, February 12 at 12PM ET here. View Show Notes From This Episode Get Free Weekly Health Tips from Dr. Hyman https://drhyman.com/pages/picks?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Sign Up for Dr. Hyman's Weekly Longevity Journal https://drhyman.com/pages/longevity?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Join the 10-Day Detox to Reset Your Health https://drhyman.com/pages/10-day-detox Join the Hyman Hive for Expert Support and Real Results https://drhyman.com/pages/hyman-hive This episode is brought to you by Qualia, Seed, PerfectAmino, Sunlighten, BIOptimizers and Korrus. Go to qualialife.com/hyman and use code HYMAN at checkout for an extra 15% off. Go to seed.com/hyman and use code 20HYMAN to get 20% off your first month. Go to bodyhealth.com and use code HYMAN20 to get 20% off your first order. Visit sunlighten.com and use code HYMAN to save up to $1400. Head to bioptimizers.com/hyman and use promo code HYMAN at checkout to save 15%.Upgrade your lighting. Enjoy 15% off at korrus.com/drhyman. (0:00) Rise in male infertility and testosterone issues (1:24) Global challenges in men's health and infertility awareness (4:56) Decline in semen quality and potential causes (9:52) Reducing exposure to endocrine disruptors and detoxification methods (14:51) Metabolic health's impact on testosterone and sperm quality as a vital sign (21:00) Sperm quality biomarkers and the impact of paternal age on offspring (26:28) Role of paternal health and epigenetics in pregnancy outcomes (31:29) Lifestyle and supplements to improve sperm quality (37:57) Stress and environmental factors affecting hormone levels and birth sex ratios (41:05) Erectile dysfunction: rates, causes, and treatment options (51:22) Testosterone replacement therapy: benefits and risks (1:00:08) Andropause and epigenetics in reproductive health (1:08:22) Rapid fire questions: lifestyle factors affecting sperm quality (1:09:45) Impact of cycling and sedentary lifestyle on reproductive health (1:12:46) Importance of sleep, stress management, and relaxation techniques (1:13:45) Information about swim club and supplements for fertility (1:14:44) Introduction to the Ultra Learning Series and functional fertility workshop (1:16:07) Disclaimer and gratitude to sponsors

Alzheimer's doesn't begin with memory loss. It begins years earlier with metabolic dysfunction. In this episode, Ben Azadi reveals why Alzheimer's is now being referred to as “Type 3 Diabetes” and how insulin resistance, inflammation, and chronic stress silently damage the brain long before symptoms appear. You'll learn why genetics are not your destiny, how the brain becomes starved for fuel despite high blood sugar, and why waiting for symptoms is already too late. Ben breaks down the science behind hippocampal shrinkage, reduced glucose uptake in the brain, and the role of cortisol in cognitive decline. This episode introduces the 15-Minute Brain Reboot, a simple daily protocol designed to protect and rebuild brain health: Daily fasting to switch the brain's fuel from sugar to ketones Zone 2 movement to increase blood flow and grow new brain cells Gratitude (“Vitamin G”) to lower stress hormones and protect neurons Ben also answers common questions about genetics, brain games, fasting safety, supplements, and why prevention isn't emphasized in conventional medicine. The takeaway is clear: you're not broken, you're early. With consistent daily habits, your brain can heal, adapt, and stay sharp for decades to come.

A new Nutrients study shows that drinking 12 ounces of 100% elderberry juice daily for a week helped overweight adults activate more genes that regulate how the body uses energy after meals than a placebo Elderberry juice turned on processes that help the body manage energy better — making it easier to switch between burning carbohydrates and fat for fuel Earlier research from Washington State University showed elderberry juice improved blood sugar control, increased fat burning, and shifted energy use during meal challenges Practical tip: Aim for about 12 ounces of unsweetened, 100% elderberry juice daily for seven days. Check labels to avoid added sugars, as unsweetened juice still contains about 30 to 36 grams of natural sugar per eight-ounce serving Safety first: Never eat raw elderberries, check for medication interactions (such as immunosuppressants or diabetes drugs), and consult a healthcare provider before using if you are breastfeeding or have an autoimmune condition