Podcasts about metabolic

High cholesterol has been treated as the main cause of heart disease for decades. But over the years, I've changed my mind. Today, I believe cholesterol is only part of the story, and that inflammation, insulin resistance, and metabolic health are often the real drivers of cardiovascular disease. In this encore episode, I'm revisiting one of my most talked-about Office Hours conversations to share how my thinking has evolved and why understanding the root cause of heart disease can completely change the way you approach prevention. In today's episode, I discuss: Why cholesterol alone is a poor predictor of heart disease—and the biomarkers I believe matter even more, including ApoB, lipoprotein(a), inflammation, and insulin resistance The surprising role sugar, refined carbohydrates, and metabolic dysfunction play in driving cardiovascular disease Why two people with the same cholesterol can have dramatically different heart disease risk—and how a personalized approach changes the conversation The nutrition, lifestyle, and testing strategies I use to help reduce inflammation, improve metabolic health, and lower cardiovascular risk at its source Heart disease isn't simply a cholesterol problem—it's often a metabolic and inflammatory problem. When you understand what's really driving your risk, you can stop chasing a single number and start addressing the underlying biology that supports lifelong cardiovascular health. Track your metabolic and cardiovascular health biomarkers: functionhealth.com/mark for 160+ lab tests at just $365/year. Use code MARK2026 for $50 off. Have a question you'd love answered on Office Hours? Submit it here' (0:00) The cholesterol and heart disease paradox; introduction and overview of cholesterol, inflammation, and metabolic health (1:11) Sponsor: Function Health (1:41) Traditional views vs. new science on cholesterol, inflammation, and heart disease (4:52) Inflammation and sugar as key factors in heart disease (8:41) Advanced markers: ApoB, lipoprotein fractionation, and comprehensive testing (13:57) Causes of inflammation and holistic heart disease prevention (19:35) Metabolic health risks, new technologies, and personalized interventions (22:35) Diet, exercise, lifestyle, and supplements for heart and metabolic health (25:03) Understanding heart disease beyond cholesterol (25:37) Sponsor: Brain Shaping Academy (26:33) Community engagement, sharing, and final thoughts (28:07) Sponsor acknowledgments and closing remarks

Your body has been talking to you your whole life. The question is whether anyone ever taught you to listen. In this episode, I want to widen the lens on how you read your own body. We have lost so much of the generational knowledge our mothers and grandmothers once passed down, and now we tend to wait until something hurts before we pay attention. But your body speaks in subtleties long before that. I share one of my great loves, Ayurveda, the 5,000-year-old healing system I studied for three years, and its practice of observation called the eightfold examination. What fascinates me most is how closely it aligns with modern functional nutrition's Nutrition Focused Physical Exam. We walk through what your tongue, skin, hair, nails, and eyes may be reflecting about your gut health, your nutrient status, your oxidative stress, and even your blood sugar, backed by research going back nearly 80 years. Here is what matters most. This is not about self-diagnosis. None of these signs are proof of anything on their own. They are invitations to pay attention, not verdicts to fear. My hope is that noticing your body builds confidence instead of anxiety, the quiet confidence of a woman in a loving conversation with her body rather than at war with it. If you take one small thing from this episode, try this. Tomorrow morning, look at your tongue and just notice. Do it for a week. That is the practice.   Resources Mentioned: Work with Laura: https://www.thebreastcancerrecoverycoach.com/health  Download for iPhone:  https://apps.apple.com/us/app/kajabi/id1485646310 Download for Android:  https://play.google.com/store/apps/details?id=kajabi.kajabiapp&hl=en_US Here is the link to the FREE Ayurveda Mini-Course that I talked about in this episode: https://www.thebreastcancerrecoverycoach.com/mybody   Here are the references: Foundational Asif T, Mohiuddin A, Hasan B, Pauly RR. Importance of Thorough Physical Examination: A Lost Art. Cureus. 2017;9(5):e1212. Newton C. The Functional Nutrition-Focused Physical Exam. IFNA Track 3 Module 2. Tongue Jeghers H. Nutrition: the appearance of the tongue as an index of nutritional deficiency. New England Journal of Medicine. 1942;227:221-8. Khayamzadeh M, Najafi S, Sadrolodabaei P, Vakili F, Kharrazi Fard MJ. Determining salivary and serum levels of iron, zinc and vitamin B12 in patients with geographic tongue. J Dent Res Dent Clin Dent Prospects. 2019;13(3):221-226. Chiang CP, Chang JY, Wang YP, Wu YH, Wu YC, Sun A. Atrophic glossitis: Etiology, serum autoantibodies, anemia, hematinic deficiencies, hyperhomocysteinemia, and management. J Formos Med Assoc. 2020;119(4):774-780. Skin Salem I, Ramser A, Isham N, Ghannoum MA. The Gut Microbiome as a Major Regulator of the Gut-Skin Axis. Front Microbiol. 2018;9:1459. Wang X, Li Y, Wu L, et al. Dysregulation of the gut-brain-skin axis and key overlapping inflammatory and immune mechanisms of psoriasis and depression. Biomed Pharmacother. 2021;137:111065. Jafferany M, Franca K. Psychodermatology: Basics Concepts. Acta Derm Venereol. 2016;96(217):35-7. Reunala T, Salmi TT, Hervonen K, Kaukinen K, Collin P. Dermatitis Herpetiformis: A Common Extraintestinal Manifestation of Coeliac Disease. Nutrients. 2018;10(5):602. Stefanadi EC, Dimitrakakis G, Antoniou CK, et al. Metabolic syndrome and the skin: a more than superficial association. Diabetol Metab Syndr. 2018;10:9. Hair O'Connor K, Goldberg LJ. Nutrition and hair. Clin Dermatol. 2021;39(5):809-818. Arck PC, Overall R, Spatz K, et al. Towards a "free radical theory of graying": melanocyte apoptosis in the aging human hair follicle is an indicator of oxidative stress induced tissue damage. FASEB J. 2006;20(9):1567-9. Zhang B, Ma S, Rachmin I, et al. Hyperactivation of sympathetic nerves drives depletion of melanocyte stem cells. Nature. 2020;577(7792):676-681. Poonia K, Bhalla M. Premature Graying of Hair: A Comprehensive Review and Recent Insights. Indian Dermatol Online J. 2024;15(5):721-731. Nails Singal A, Arora R. Nail as a window of systemic diseases. Indian Dermatol Online J. 2015;6(2):67-74. Cashman MW, Sloan SB. Nutrition and nail disease. Clin Dermatol. 2010;28(4):420-5. Eyes Knapp A. The Eye as a Guide to Latent Nutritional Deficiency Diseases. Bull N Y Acad Med. 1946. Wakamatsu TH, Dogru M, Tsubota K. Tearful relations: oxidative stress, inflammation and eye diseases. Arq Bras Oftalmol. 2008;71(6 Suppl):72-9. Seydou A, Arnould L, Gabrielle PH, et al. Plasma Fatty Acids Pattern and Dry Eye Disease in the Elderly: The Montrachet Population-Based Study. Nutrients. 2022;14(11):2290. Bu Y, Shih KC, Tong L. The ocular surface and diabetes, the other 21st Century epidemic. Exp Eye Res. 2022;220:109099. Rahman A, Yahya K, Ahmed T, Sharif-Ul-Hasan K. Diagnostic value of tear films tests in type 2 diabetes. J Pak Med Assoc. 2007;57(12):577-81. Seifart U, Strempel I. Trockenes Auge und Diabetes mellitus [The dry eye and diabetes mellitus]. Ophthalmologe. 1994;91(2):235-9. Campagnoli LIM, Varesi A, Barbieri A, Marchesi N, Pascale A. Targeting the Gut-Eye Axis: An Emerging Strategy to Face Ocular Diseases. Int J Mol Sci. 2023;24(17):13338. Let's Connect! If this episode helped you breathe a little easier, please share it with a friend or leave a review. Every share helps spread this message of hope, healing, and whole-person wellness.

In this Sister Solo, Jenna walks through the 5 pillars that finally healed her after years of chronic gut issues, inflammation, bloating, hormonal acne, and feeling like sh*t no matter what she tried.If you've been doing all the "right" wellness things — eating clean, drinking water, taking supplements — and you still feel exhausted, bloated, or stuck in your body, this episode is for you.Jenna and Jill get real about Jenna's 2019-2023 era — the symptoms she normalized, the all-or-nothing trap that made her sicker, and the moment she realized the answer wasn't more restriction. It was less.We walk through the exact 5-pillar framework that changed everything — including the pillar nobody in wellness wants to talk about.In this episode:Jenna's "before" era: the symptoms she normalized that weren't normalThe all-or-nothing wellness trap and how it made her sickerPillar 1: Drainage — the foundation nobody talks aboutPillar 2: Gut health — and why probiotics aren't the answerPillar 3: Metabolic health — and why undereating is making women sickerPillar 4: Strength training — the day everything changedPillar 5: Curating a slower, intentional, balanced life — the pillar nobody talks aboutThe toxic friend auditWhat every woman feeling stuck in her body needs to hearConnect with us:Follow Gut Talk on Instagram: @guttalkpodcastIf this episode resonated, share it with a friend who needs to hear it.

Show notes at pharmacyjoe.com/episode1142 In this episode, I'll discuss sodium bicarbonate for critically ill adult patients with metabolic acidosis and shock.

Natasha believes that healthy is a  lifestyle and not just a diet that can be handed to you.  Where, how and when we eat can have just as much of an effect as what we eat.  Addressing things like circadian rhythms, cycle timing, nervous system tone, mindset, sleep - is where she has seen coaching make huge shifts, especially when it comes to women who have daily, weekly and hormonal monthly variations.  After graduating as a Holistic Nutritionist in 2010 and as a practicing Metabolic Health Coach, Natasha realized health is not a one size fits all approach. By addressing metabolism,  getting back to giving ourselves what we evolved to eat, moving the way we are intended to move, and taking our health into our own hands - life opens up and really begins to shine.     IG: vazwellness FB: PNWmetabolic Website: https://www.pnwmetabolic.com Timestamps: 00:00 Trailer 00:31 Introduction 05:27 Considering a career in nutrition 10:11 Discussing dietary documentaries 11:04 Challenges of northern diets 14:21 Embracing local and sustainable eating 17:47 Switching to a carnivore diet 22:48 Discussing insulin resistance and gut health 24:35 Improving health with dietary changes 29:22 Understanding different types of hunger 33:50 Exploring Carnivore diet and fasting 35:14 Clinicians sharing personal diet experiences 38:29 Buying beef directly from farmer 41:48 Empowerment through personal health Join Revero now to regain your health: https://revero.com/YT Revero.com is an online medical clinic for treating chronic diseases with this root-cause approach of nutrition therapy. You can get access to medical providers, personalized nutrition therapy, biomarker tracking, lab testing, ongoing clinical care, and daily coaching. You will also learn everything you need with educational videos, hundreds of recipes, and articles to make this easy for you. Join the Revero team (medical providers, etc): https://revero.com/jobs ‪#Revero #ReveroHealth #shawnbaker  #Carnivorediet #MeatHeals #AnimalBased #ZeroCarb #DietCoach  #FatAdapted #Carnivore #sugarfree Disclaimer: The content on this channel is not medical advice. Please consult your healthcare provider.

Research Shows Possible Metabolic Links Between Periodontitis and a High-fat DietBy Today's RDH ResearchOriginal article published on Today's RDH: https://www.todaysrdh.com/research-shows-possible-metabolic-links-between-periodontitis-and-a-high-fat-diet/Need CE? Start earning CE credits today at ⁠https://rdh.tv/ce⁠ Get daily dental hygiene articles at ⁠https://www.todaysrdh.com⁠ Follow Today's RDH on Facebook: ⁠https://www.facebook.com/TodaysRDH/⁠Follow Kara RDH on Facebook: ⁠https://www.facebook.com/DentalHygieneKaraRDH/⁠Follow Kara RDH on Instagram: ⁠https://www.instagram.com/kara_rdh/⁠

Jay breaks down why most “metabolism reset” programs fail and reveals a smarter, research-backed 30-day approach that actually works. Drawing from decades of experimentation and human studies, he dives into the real science of adaptive thermogenesis, the dangers of yo-yo dieting, and how to rebuild your hormonal environment for lasting results.Key topics include:Strategic diet breaks at maintenance calories to reverse metabolic slowdownHigh-protein intake and resistance training to positive muscular failure (PMF)Alternate-day fasting, metabolic flexibility, and smart HIIT protocolsThe role of peptides and targeted compounds to accelerate repairWhy muscle preservation is the ultimate key to a thriving metabolismIf you're tired of crash diets that leave you worse off, this conversation delivers practical, no-BS strategies to reignite your metabolism, preserve muscle, and build sustainable habits that support your long-term health, energy, and purpose.Jay also shares insights from his 30 Days 2 Shredz protocol and Metabolic Awakening framework—tools designed to help you stop fighting your biology and start working with it.https://jaycampbell.com/Become a supporter of this podcast: https://www.spreaker.com/podcast/i-am-refocused-radio--2671113/support.Subscribe now at YouTube.com/@RefocusedNetworkThank you for your time. 

A patient asked me this recently: "Dr. Shelley, I've heard that GLP-1 medications can cause muscle loss. Does that mean they can hurt my bones too?" It's an excellent question—and one we don't talk about nearly enough. In this episode, I'm walking you through what the research actually shows about GLP-1 medications and bone health, why weight loss itself poses a different risk to your skeleton, and the five non-negotiable steps you need to take to protect your bones while losing weight. This is the bone health conversation you need to hear before—or while—taking a GLP-1. Episode Highlights: What GLP-1 medications are and how they work in your body Does GLP-1 directly damage bones? What the research says The real issue: weight loss and how it affects bone health How your bones stay strong and why muscle matters Muscle loss during weight loss on GLP-1s (body composition breakdown) Who's at higher risk for weak bones and should be monitoring Eat enough protein: how much you actually need Strength training and resistance exercises for bone protection Getting enough calcium and vitamin D The DEXA bone density scan and when you should ask for one Connect with Dr. Alicia Shelly: Website | drshellymd.com Facebook | www.facebook.com/drshellymd Instagram | @drshellymd Linked In | www.linkedin.com/in/drshellymd Twitter | @drshellymd About Dr. Alicia Shelly Dr. Alicia Shelly was raised in Atlanta, GA. She received her Doctorate of Medicine from Case Western Reserve University School of Medicine in Cleveland, OH.  Dr. Shelly has been practicing Primary Care and Obesity medicine since 2014.  In 2017, she became a Diplomat of the American Board of Obesity Medicine. She is the lead physician at the Wellstar Medical Center Douglasville. She started a weekly podcast & Youtube channel entitled Back on Track: Achieving Healthy Weight loss,  where she discusses how to get on track and stay on track with your weight loss journey. She has spoken for numerous local and national organizations, including the Obesity Medicine Association, and the Georgia Chapter of the American Society of Metabolic and Bariatric Surgeons. She has been featured on CNN, Fox 5 News, Bruce St. James Radio show, Upscale magazine, and Shape.com. She was named an honoree of the 2021 Atlanta Business Chronicle's 40 under 40 award. She also is a collaborating author for the, "Made for More: Physician Entrepreneurs who Live Life and Practice Medicine on their own terms''.   Resources: FREE! Discover the 5 Reasons Your Weight-Loss Journey Has Gotten Derailed (And How To Get Back On Track!)

If you've ever wondered why weight loss gets harder the longer you diet, why every expert seems to have a different answer, or whether you really need to count calories to lose fat, this episode is for you.In Part 1 of this 4-part nutrition series, Britany breaks down the foundation of fat loss: calorie deficits, metabolism, metabolic adaptation, and why preserving muscle matters just as much as losing weight. She also explains why crash diets backfire, how popular diets actually work, and what women in perimenopause and menopause need to know about fat loss.In this episode, we discuss: What a calorie deficit actually is  The 4 ways your body burns calories  Why daily movement matters more than most people realize  Metabolic adaptation and why weight loss slows over time  Why bigger calorie deficits aren't always better  How keto, intermittent fasting, paleo, and other diets really work  The difference between weight loss and fat loss  Why preserving muscle is critical during a fat-loss phase  How strength training supports fat loss  The role of muscle in metabolism and long-term success  Fat loss during perimenopause and menopause  Why aggressive dieting often backfiresMentioned in the podcast:Free calorie calculatorSIGN UP FOR BRITANY'S NEWSLETTERhttps://britany.myflodesk.com/filterfreeASK BRITANY A QUESTION OR REQUEST A TOPIChttps://forms.gle/j9NC3yM5vrdBs8mJ8

Send us Fan MailThe possible role of deuterium (heavy isotope of hydrogen) in regulating cell division, mitochondrial metabolism & cancer.TOPICS DISCUSSED:Deuterium Basics: Deuterium is twice as massive as regular hydrogen; natural water contains ~150 ppm, with stronger oxygen-deuterium bonds slowing reactions compared to oxygen-hydrogen.Mitochondrial Role: Healthy mitochondria produce deuterium-depleted metabolic water (~110 ppm from fat oxidation vs. ~150 ppm from carbs), helping maintain low cellular D:H ratios.Cell Growth Regulation: Lower deuterium slows cell division in vitro; cells sense small D:H changes, with higher levels (near/above 150 ppm) promoting growth.In Vitro Evidence: DDW (e.g., 25-125 ppm) can reduce proliferation and alters cancer-related gene expression.Animal Models: DDW caused tumor regression in mice with transplanted human cancers and showed possible efficacy in veterinary use for dogs and cats.Human Prostate Cancer: Phase 2 randomized study showed greater Prostate-Specific Antigen (PSA) reduction, tumor shrinkage, and better 1-year survival with DDW plus standard therapy vs. placebo.Dietary Modulation: Ketogenic/high-fat diets lower body deuterium from lipid oxidation.Broader Implications: Potential in neurodegeneration models; larger trials needed for registration as adjunct cancer therapy.ABOUT THE GUEST: Gábor Somlyai, PhD is a molecular biologist who pioneered deuterium depletion studies at the National Institute of Oncology in Hungary. His primary work focuses on the role of deuterium in living organisms and the development of deuterium-depleted water for cancer therapy.Support the showHealth Products by M&M Partners:AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models.OmegaQuant: At-home blood testing to see fatty acid profiles, including omega-3 fatty acids. Use link to see options and support M&M.SiPhox Health: Comprehensive, cost-effective bloodwork from the comfort of home. Use code TRIKOMES for 20% off.KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime)SporesMD: Premium mushrooms products (gourmet mushrooms, nootropics, research). Use code 'nickjikomes' for 20% off.For all the ways you can support my efforts

Metabolic syndrome now affects about 1 in 4 adults worldwide, with cases rising rapidly across nearly every country and age group, which means your personal risk is higher than it was just a generation ago The condition develops silently through a combination of abdominal fat, high blood sugar, high blood pressure, and abnormal cholesterol, often without clear symptoms until damage is already underway Your daily habits drive the condition, as processed foods, low movement, chronic stress, and poor sleep disrupt how your body produces and uses energy Insulin resistance sits at the center of the problem, creating a chain reaction that affects your metabolism, blood vessels, and hormone balance all at once You can reverse the trajectory by restoring cellular energy through better food choices, eliminating seed oils, increasing daily movement, getting regular sunlight, and improving sleep and stress control

Inside the venom of a desert lizard, scientists found a molecule that does something the diet industry spent 50 years failing to do. It quietly switches off hunger. That molecule is now the most talked about drug on the planet, and it's sitting in the fridges of millions of people who couldn't explain how it works if you paid them.Dr Tom Buckley, 30 years in medicine and a professor at Sydney University, has looked at the evidence and called these drugs revolutionary.But what about "Ozempic face"? What if the wait comes back after you stop? Who should never touch these drugs? Dr Tom and Andrew get into the science so you finally have all the answers you need. 00:00 – A desert lizard that eats twice a year 03:32 – What a GLP-1 actually is, in plain English 07:36 – Ghrelin and leptin: hunger and fullness, explained 10:23 – The venom that cracked the hunger code 14:06 – Why your body is built to hold onto fat 15:19 – How to raise GLP-1 without a prescription 18:10 – Become the CEO of your body and brain 22:10 – You don't lose fat cells, they shrink 24:39 – "Ozempic face," and why you lose weight slowly 28:17 – The "Limitless" effect: cognitive horsepower 29:28 – 76 trials, 40,000 patients: the evidence 30:47 – Lancet 2024: heart attacks and strokes down 32:11 – Why Tom calls these drugs regenerative 34:18 – Who should never take it 35:23 – The side effects nobody mentions upfront 41:19 – On it and off it: what you have to get right 48:14 – Most regain 75% within a year of stopping 50:09 – Metabolic rebound: worse than where you started 52:51 – The hidden economy GLP-1s are reshaping 56:13 – Tom's cliff notesYou can find Dr Tom at his LinkedIn: https://www.linkedin.com/in/tom-buckley-06a76b98/ Use Code "PQPODCAST10" to get 10% off your Lumo Coffee order:https://lumocoffee.com/ Interested in sharing your story? Email Producer Shannon at support@performanceintelligence.com today with your story and contact details. Learn more about Andrew and Performance Intelligence: https://performanceintelligence.com/Find out more about Andrew's Keynotes : https://performanceintelligence.com/keynotes/Follow Andrew May: https://www.instagram.com/andrewmay/Watch the Performance Intelligence Podcast on Youtube: https://www.youtube.com/@performanceintelligencepodcastIf you enjoy the podcast, we would really appreciate you leaving a short review on Apple Podcasts, Spotify or Google Play. It takes less than 60 seconds and really helps us build our audience and continue to provide high quality guests.

Fewer than 40% of people with PTSD respond to standard care. For the intrusive symptoms at the core of the disorder, response rates may be lower than 15%. So what options remain for patients who have not responded to existing treatments?Dr. Keren Doenyas-Barak, director of the PTSD program at the Sagol Center for Hyperbaric Medicine and Research and a faculty member at Tel Aviv University, has treated close to 1,000 civilian and military patients and led sham-controlled trials that are helping reshape how hyperbaric medicine is studied.She walks host Dr. Dominic D'Agostino through the protocol her clinic uses—60 sessions over 12 weeks, with oxygen cycled at two atmospheres—the 35% CAPS-score improvement associated with continued progress after treatment ends, and the reported two-year outcomes, including improved occupational function, roughly double the proportion of patients living with a partner, and sharp drops in benzodiazepine and cannabis use. She also details the convincing sham control her team engineered after concluding that earlier placebo arms may have delivered a physiologically active dose.Questions Answered in This Episode:What hyperbaric protocol is best supported for treatment-resistant PTSD?What does a 35% reduction in CAPS score predict about long-term recovery?Which outcomes beyond symptom scores changed most for patients?How did the team build a hyperbaric sham that patients genuinely could not detect?Which safety measures are non-negotiable in a hyperbaric PTSD clinic?Does a patient's baseline metabolic fitness predict their response to HBOT, and can the treatment affect cardiometabolic risk?A rigorous, frontline examination of what responsible hyperbaric medicine actually requires, led by a clinician helping to build its evidence base.Special thanks to the sponsors of this episode:✅ Toups and Co – Get 15% off your first order with code METABOLIC here.✅ iRestore – Get a huge discount on the Elite and the Illumina bundle with the code LINK here.✅ MudWtr – Get up to 43% off + free shipping and a free rechargeable frother with code METABOLICLINK here.In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel!Find us on social: InstagramFacebookYouTubeLinkedInPlease keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.

Jun 15, 2026 – Metabolic health expert Jim LaValle joins Jim Puplava to explain why being "disease free" doesn't mean you're truly healthy. They explore the overlooked drivers of premature aging, including chronic stress, poor sleep, and insulin resistance...

If you enjoy this episode, we're sure you will enjoy more content like this on The Occult Rejects.  In fact, we have curated playlists on occult topics like grimoires, esoteric concepts and phenomena, occult history, analyzing true crime and cults with an occult lens, Para politics, and occultism in music. Whether you enjoy consuming your content visually or via audio, we've got you covered - and it will always be provided free of charge.  So, if you enjoy what we do and want to support our work of providing accessible, free content on various platforms, please consider making a donation to the links provided below.  Thank you and enjoy the episode!Links For The Occult Rejectshttps://linktr.ee/theoccultrejectsOccult Research Institutehttps://www.occultresearchinstitute.org/Substackhttps://substack.com/@theoccultrejects?r=7auau0&utm_campaign=profile&utm_medium=profile-pageCash Apphttps://cash.app/$theoccultrejectsVenmo@TheOccultRejectsBuy Me A Coffeebuymeacoffee.com/TheOccultRejectsPatreonhttps://www.patreon.com/TheOccultRejectsBiblioBernardi, Luciano, Peter Sleight, Gabriele Bandinelli, Simone Cencetti, Luciano Fattorini, Johanna Wdowczyc-Szulc, and Alfonso Lagi. “Effect of Rosary Prayer and Yoga Mantras on Autonomic Cardiovascular Rhythms: Comparative Study.” BMJ 323, no. 7327 (2001): 1446–1449.Benson, Herbert, John W. Lehmann, Mark S. Malhotra, Ralph F. Goldman, Jeffrey Hopkins, and Mark D. Epstein. “Body Temperature Changes During the Practice of g Tum-mo Yoga.” Nature 295 (1982): 234–236.Benson, Herbert, Mark S. Malhotra, Ralph F. Goldman, Gregory D. Jacobs, and Jeffrey Hopkins. “Three Case Reports of the Metabolic and Electroencephalographic Changes During Advanced Buddhist Meditation Techniques.” Behavioral Medicine 16, no. 2 (1990): 90–95.Bremer, Brandon, Lorenzo Wu, Zoran Josipovic, and colleagues. “Mindfulness Meditation Increases Default Mode, Salience, and Central Executive Network Connectivity.” Scientific Reports 12 (2022).Brewer, Judson A., Patrick D. Worhunsky, Jeremy R. Gray, Yi-Yuan Tang, Jochen Weber, and Hedy Kober. “Meditation Experience Is Associated with Differences in Default Mode Network Activity and Connectivity.” Proceedings of the National Academy of Sciences 108, no. 50 (2011): 20254–20259.Britton, Willoughby B. and colleagues. Research associated with the “Varieties of Contemplative Experience” project on meditation-related challenges, adverse effects, and safety considerations in contemplative practice.Crowley, Aleister. Liber E vel Exercitiorum sub figura IX. In the A∴A∴ training corpus. Relevant sections include asana, pranayama, and dharana as foundational magical exercises.Dennison, Paul. “Insights From an EEG Study of Buddhist Jhāna Meditation.” Frontiers in Human Neuroscience 13 (2019).Fialoke, Shantala, Helen Weng, and colleagues. “Functional Connectivity Changes in Meditators and Novices During Yoga Nidra Practice.” Scientific Reports 14 (2024).Fox, Kieran C. R., Savannah Nijeboer, Matthew L. Dixon, James L. Floman, Melissa Ellamil, Samuel P. Rumak, Peter Sedlmeier, and Kalina Christoff. “Is Meditation Associated with Altered Brain Structure? A Systematic Review and Meta-analysis of Morphometric Neuroimaging in Meditation Practitioners.” Neuroscience & Biobehavioral Reviews 43 (2014): 48–73.Hölzel, Britta K., James Carmody, Mark Vangel, Christina Congleton, Sita M. Yerramsetti, Tim Gard, and Sara W. Lazar. “Mindfulness Practice Leads to Increases in Regional Brain Gray Matter Density.” Psychiatry Research: Neuroimaging 191, no. 1 (2011): 36–43.Kozhevnikov, Maria, Olesya Louchakova, Zoran Josipovic, and Michael A. Motes. “The Enhancement of Visuospatial Processing Efficiency Through Buddhist Deity Meditation.” Psychological Science 20, no. 5 (2009): 645–653.Kozhevnikov, Maria, John A. Elliott, Jennifer Shephard, and Klaus Gramann. “Neurocognitive and Somatic Components of Temperature Increases During g-Tummo Meditation: Legend and Reality.” PLOS ONE 8, no. 3 (2013): e58244.Laukkonen, Ruben E., and Heleen A. Slagter. “From Many to (N)one: Meditation and the Plasticity of the Predictive Mind.” Neuroscience & Biobehavioral Reviews 128 (2021): 199–217.Lomas, Tim, Juan Carlos Ivtzan, and Itai K. Fu. “A Systematic Review of the Neurophysiology of Mindfulness on EEG Oscillations.” Neuroscience & Biobehavioral Reviews 57 (2015): 401–410.Lott, James P., Richard J. Davidson, John D. Dunne, Thupten Jinpa, Antoine Lutz, and colleagues. “No Detectable Electroencephalographic Activity After Clinical Declaration of Death Among Tibetan Buddhist Meditators in Apparent Tukdam.” Frontiers in Psychology 11 (2021): 599190.Lutz, Antoine, Lawrence L. Greischar, Nancy B. Rawlings, Matthieu Ricard, and Richard J. Davidson. “Long-term Meditators Self-induce High-amplitude Gamma Synchrony During Mental Practice.” Proceedings of the National Academy of Sciences 101, no. 46 (2004): 16369–16373.Lutz, Antoine, Julie Brefczynski-Lewis, Tom Johnstone, and Richard J. Davidson. “Regulation of the Neural Circuitry of Emotion by Compassion Meditation: Effects of Meditative Expertise.” PLoS ONE 3, no. 3 (2008): e1897.Matko, Karin, Peter Sedlmeier, and colleagues. “Adverse Effects of Meditation and Mindfulness in Clinical Practice.” 2025.Patanjali. Yoga Sutras. Especially Book III, traditionally describing dharana, dhyana, and samadhi.Riegner, Gretchen, Fadel Zeidan, and colleagues. “Disentangling Self from Pain: Mindfulness Meditation-Induced Pain Relief Is Driven by Thalamic-Default Mode Network Decoupling.” Pain 164, no. 2 (2023): 280–291.Tang, Yi-Yuan, Britta K. Hölzel, and Michael I. Posner. “The Neuroscience of Mindfulness Meditation.” Nature Reviews Neuroscience 16 (2015): 213–225.Vago, David R., and David A. Silbersweig. “Self-awareness, Self-regulation, and Self-transcendence: A Framework for Understanding the Neurobiological Mechanisms of Mindfulness.” Frontiers in Human Neuroscience 6 (2012): 296.Zeidan, Fadel, and colleagues. Research on mindfulness meditation, pain modulation, attention, and the neural mechanisms of pain relief.Slagter, Heleen A., Antoine Lutz, Lawrence L. Greischar, Andrew D. Francis, Sander Nieuwenhuis, James M. Davis, and Richard J. Davidson. “Mental Training Affects Distribution of Limited Brain Resources.” PLOS Biology 5, no. 6 (2007): e138. Use for: Attentional blink, limited attention, and meditation changing how the brain allocates resources.Hölzel, Britta K., James Carmody, Mark Vangel, Christina Congleton, Sita M. Yerramsetti, Tim Gard, and Sara W. Lazar. “Mindfulness Practice Leads to Increases in Regional Brain Gray Matter Density.” Psychiatry Research: Neuroimaging 191, no. 1 (2011): 36–43. Use for: Neuroplasticity, repeated practice leaving measurable marks on the brain, and the “practice writes itself into the practitioner” idea.Laukkonen, Ruben E., and Heleen A. Slagter. “From Many to (N)one: Meditation and the Plasticity of the Predictive Mind.” Neuroscience & Biobehavioral Reviews 128 (2021): 199–217. Use for: Predictive processing, the brain as a prediction machine, meditation loosening automatic models, and the “veil” argument.Lutz, Antoine, Julie Brefczynski-Lewis, Tom Johnstone, and Richard J. Davidson. “Regulation of the Neural Circuitry of Emotion by Compassion Meditation: Effects of Meditative Expertise.” PLOS ONE 3, no. 3 (2008): e1897. Use for: Compassion meditation, loving-kindness, emotional circuitry, and training compassion as a repeatable state rather than just a moral idea.Kok, Bethany E., Kimberly A. Coffey, Michael A. Cohn, Lahnna I. Catalino, Tanya Vacharkulksemsuk, Sara B. Algoe, Marc A. Brantley, and Barbara L. Fredrickson. “How Positive Emotions Build Physical Health: Perceived Positive Social Connections Account for the Upward Spiral Between Positive Emotions and Vagal Tone.” Psychological Science 24, no. 7 (2013): 1123–1132. Use for: Loving-kindness, social connection, vagal tone, and the cautious “social nervous system” bridge.Black, David S., and George M. Slavich. “Mindfulness Meditation and the Immune System: A Systematic Review of Randomized Controlled Trials.” Annals of the New York Academy of Sciences 1373, no. 1 (2016): 13–24. Use for: Immune-system caution, inflammation markers, cell-mediated immunity, biological aging, and why this material should be framed as tentative rather than miracle healing.Burić, Ivana, Miguel Farias, Jonathan Jong, Christopher Mee, and Inti A. Brazil. “What Is the Molecular Signature of Mind–Body Interventions? A Systematic Review of Gene Expression Changes Induced by Meditation and Related Practices.” Frontiers in Immunology 8 (2017): 670. Use for: Stress biology, inflammatory gene expression, NF-kB-related language, and the cautious claim that mind-body practices may affect biology below ordinary mood.Also want to remind people about the website, if you're into reading we have tons of information by multiple contributors, and we got t-shirts up on the site if you're interested. Fun fact, the art is all based on the eyeball. A

Discover why hormones are off and what's really driving the imbalance. In this episode, we break down five root causes — from gut dysfunction and disrupted sleep to chronic stress, appetite dysregulation, and omega-3 deficiency — and walk through what you can actually do to fix it. FEATURED PRODUCT Berberine is a powerful botanical compound that acts as a natural GLP-1 supporter — the same metabolic pathway targeted by medications like Ozempic — helping regulate blood sugar, reduce insulin resistance, and restore appetite signaling from the gut. Since metabolic hormones like insulin and leptin are the first to derail your entire hormone cascade, Berberine directly addresses one of the deepest root causes discussed in this episode. It also supports gut microbiome diversity, making it a foundational tool for anyone working to reclaim hormonal balance naturally.

Can retatrutide finally be the breakthrough obesity treatment we've been waiting for? The answer is yes—and the data is stunning. In this episode I'm walking you through the biggest obesity medicine discovery from the ADA's 86th Scientific Session: retatrutide, a triple hormone receptor agonist showing weight loss results that rival bariatric surgery. You'll learn what makes retatrutide different from Wegovy and Zepbound, the stunning results from the Triumph 1 trial, what the side effects actually look like, and when this medication will finally be available. Weight loss medications are evolving faster than ever. But what you really need to know is what these results mean for your health. Listen now! Episode Highlights: Retatrutide is a triple hormone agonist that targets GLP-1, GIP, and glucagon receptors Participants lost an average of 28.3% of their body weight in 80 weeks Two-thirds of participants achieved a normal BMI—moved from obese to healthy weight Nearly everyone with prediabetes reversed it and returned to normal blood sugar Over 70% reduction in knee osteoarthritis pain and 60% reduction in sleep apnea severity The highest discontinuation rate due to side effects was only 11%—mainly GI issues Retatrutide is not yet FDA approved but anticipated to launch early 2027 Connect with Dr. Alicia Shelly: Website | drshellymd.com Facebook | www.facebook.com/drshellymd Instagram | @drshellymd Linked In | www.linkedin.com/in/drshellymd Twitter | @drshellymd   About Dr. Alicia Shelly Dr. Alicia Shelly was raised in Atlanta, GA. She received her Doctorate of Medicine from Case Western Reserve University School of Medicine in Cleveland, OH.  Dr. Shelly has been practicing Primary Care and Obesity medicine since 2014.  In 2017, she became a Diplomat of the American Board of Obesity Medicine. She is the lead physician at the Wellstar Medical Center Douglasville. She started a weekly podcast & Youtube channel entitled Back on Track: Achieving Healthy Weight loss,  where she discusses how to get on track and stay on track with your weight loss journey. She has spoken for numerous local and national organizations, including the Obesity Medicine Association, and the Georgia Chapter of the American Society of Metabolic and Bariatric Surgeons. She has been featured on CNN, Fox 5 News, Bruce St. James Radio show, Upscale magazine, and Shape.com. She was named an honoree of the 2021 Atlanta Business Chronicle's 40 under 40 award. She also is a collaborating author for the, "Made for More: Physician Entrepreneurs who Live Life and Practice Medicine on their own terms''.   Resources: FREE! Discover the 5 Reasons Your Weight-Loss Journey Has Gotten Derailed (And How To Get Back On Track!)

Bryan Tucker joins host Catherine Glass to explore why kidney stone disease is becoming increasingly common worldwide. From dietary and metabolic drivers to male predominance and prevention strategies, this episode examines how nephrolithiasis reflects broader shifts in metabolic health and lifestyle. Timestamps: 01:13 – Increased prevalence 03:19 – Metabolic issues 04:30 – Increased prevalence in men 06:50 – Population-level prevention strategies 08:24 – Cardiometabolic syndrome

** Come to Macro ‘n Chill, the online gathering where we listen to the podcast together and discuss what we learned and where we agree or disagree. Tuesday, June 16, 8pm ET/5pm PT. Use this link to register: https://us06web.zoom.us/meeting/register/Qm85bGIOSF2H_uNMwOmWtQEcosocialist author, Ian Angus, talks with Steve about his book Metabolic Rifts: Capitalism's Assault on the Earth System. They explore the deep, sometimes invisible ways that capitalism disrupts the planet's fundamental life cycles –– from soil depletion and artificial fertilizers to the carbon cycle driving global warming.Ian traces the concept of “metabolic rift” from Marx and Engels through a long socialist lineage, making the case that ecological critique has always been central to the Marxist tradition. (Indeed, some Marxists might argue that “eco-” is an unnecessary qualifier; “socialism” is enough!)Steve brings up the MMT basics challenging the austerity narrative that blocks ecological reconstruction. He reminds us that the state, as the currency issuer, can de-commodify the essentials of life, namely food, water, housing, and healthcare. However, as Ian bluntly states: “The problem is that it's not our government, it's their government.” Reformism and electoralism are dead ends.While listeners may disagree with some of Ian's interpretations of Soviet history, those comments do not negate the episode's compelling analysis that capitalism's DNA demands endless accumulation and profit. Combating the ecological crisis is inseparable from the struggle to overcome capitalism.Ian Angus is founder and editor of the online ecosocialist journal, Climate & Capitalism and a founding member of the Global Ecosocialist Network. Among his many books are The War Against the Commons: Dispossession and Resistance in the Making of Capitalism (Monthly Review Press, 2023), A Redder Shade of Green: Intersections of Science and Socialism (Monthly Review Press, 2017) and Facing the Anthropocene: Fossil Capitalism and the Crisis of the Earth System (Monthly Review Press, 2016). His most recent is Metabolic Rifts: Capitalism's Assault on the Earth System. (Monthly Review Press, 2026),@ecosocialism1 on X

Your body after a baby was never a calorie problem. It is a metabolic one. In this Her Stack episode I am walking you through exactly how to restore your metabolism so body composition follows. The goal is not weight loss. The goal is metabolic restoration. Body comp is downstream. I am breaking down the four drivers that actually run body composition (insulin, thyroid, sleep, growth hormone), the four pillars to address them (nutrition, lifestyle, supplements, peptides), and the exact peptide sequencing for women. Plus my honest take on GLP-1s including semaglutide, tirzepatide, and retatrutide, where they actually fit, and why microdosing makes more sense than chasing the scale. I also share what nobody talks about. Eating less postpartum often makes body composition worse. Breastfeeding is sequencing, not failure. Growth hormone is the layer women never hear about, so they plateau and blame their age when it was a fixable signal the whole time. Join The LongHer Life for women-specific guidance on peptides, hormones, and longevity.   I TALK ABOUT: 00:00 Welcome back to the Her Stack series 00:53 Updates: working with me one-on-one and my new peptide planner 06:15 Why body composition not weight, and why metabolism not calories 07:01 The four drivers and four pillars framework 09:00 Driver 1: Insulin resistance and why stubborn middle fat is an insulin problem, not a calorie problem 11:30 Driver 2: Thyroid, and why TSH alone misses Free T3 (the worker hormone) 14:50 Driver 3: Sleep, cortisol, and the loop back to insulin resistance 19:32 Driver 4: Growth hormone, the layer nobody talks about that's blunted postpartum and through aging 22:19 The labs to actually ask for: fasting insulin, Free T3, IGF-1, DHEA-S, plus a 2-week CGM 24:30 Pillar 1: Nutrition (protein floor of 120g, leucine at every meal, food order, fiber, and why you should NOT under-eat) 28:06 Why leucine flips the muscle-building switch 35:00 Pillar 2: Lifestyle and biohacking (lift 3x a week, walk 7-10k steps, zone 2, cold and heat, red light, and the fringe tier honestly) 45:30 Pillar 3: Supplements (creatine, magnesium glycinate, myo-inositol, omega-3, berberine, and breastfeeding sequencing) 51:01 Berberine, AMPK, and "nature's metformin" 55:30 Pillar 4: The peptide stack starts here with AOD-9604 56:00 AOD-9604, the growth hormone fragment, why I am personally taking it right now 01:02:00 MOTS-c, the "exercise in a molecule" mitochondrial peptide 01:05:00 5-Amino-1MQ and releasing the brake on fat cells 01:07:00 Sermorelin, the gentle GH entry (what a secretagogue actually is) 01:10:00 CJC-1295, Ipamorelin, and Tesamorelin for post-weaning GH restoration 01:13:00 The GLP-1 honest take: semaglutide, tirzepatide, and the retatrutide question 01:14:00 Why retatrutide is called the triple agonist and where it fits (and where it doesn't) 01:19:27 Recap and wrap-up   RESOURCES: Work with me one-on-one on your peptide stack and protocol. The Her Stack Planner, the first peptide tracking journal built around female biology. Free Peptide Masterclass for Women. Join The LongHer Life for women-specific guidance on peptides, hormones, and longevity.   LET'S CONNECT: Instagram, TikTok, Facebook Shop my favorite health products Listen on Spotify, Apple Podcasts, YouTube Music

Today we have Dr. Dominic D'Agostino, who over the past 10 years has been a frequent guest on STEM-Talk. Today Dom joins us to give us an update on his recent research into ketogenic metabolic therapies, ketone supplements as well as hyperbaric oxygen therapy for traumatic brain injuries. Dom and his lab at the University of South Florida have published more than 20 papers since his last appearance on STEM-Talk in 2023. Dom is an Associate Professor in the Department of Molecular Pharmacology and Physiology at South Florida's Morsani College of Medicine. Dom has a background in neuroscience, molecular pharmacology, nutrition and physiology. In addition to developing and testing metabolic-based therapies, Dom's lab also investigates seizure disorders, brain cancer, neurodegenerative diseases and rare genetic-metabolic disorders. Show notes: [00:03:28] Dawn welcomes Dom back to the show and explaining that he has been quite busy since his last appearance, authoring or co-authoring more than 20 papers. Over the past several years, Dom has been helping to advance the science and application of ketogenic metabolic therapy (KMT) with colleagues at Moffitt Cancer Center, particularly focusing on using KMT to enhance immune-based therapies for certain types of cancers. Dawn asks Dom about this collaboration. [00:05:04] Dawn explains that ketogenic metabolic therapy is a dietary approach that focuses on a high-fat/low-carb diet to reduce glucose availability for cancer cells, potentially slowing their growth and improving treatment outcomes. It has been explored as a complimentary treatment for a variety of cancers including gliomas by shifting the metabolism of tumor cells away from glucose. Dawn asks Dom to explain what is involved in KMT. [00:06:58] Dawn clarifies that KMT requires less than 20-25 grams of carbohydrates per day, and that ketosis is a metabolic state in which the body switches from glucose metabolism to metabolizing fats in the form of ketones. Dawn goes on to explain that cancer cells typically consume glucose at a higher rate than normal cells. However, cancer cells are also very adaptable, and Dawn asks Dom to talk about this feature of cancer cells. [00:09:14] Ken explains that KMT has shown the most promise in treating high-grade gliomas, or brain cancers, such as glioblastoma, which is the most aggressive primary brain tumor in adults. Ken explains that Dom was part of a massive review titled “Clinical research framework proposal for ketogenic metabolic therapy in glioblastoma,” which proposed guidelines for the management of glioblastoma based on an understanding of cancer as a metabolic disease, particularly involving mitochondria. Ken asks Dom to talk about this review. [00:11:21] From a patient advocacy perspective, Ken notes that the review recommends that there should be an aggressive education campaign that can arm patients with knowledge about KMT and other novel therapies. Ken asks Dom to talk about that recommendation. [00:13:15] Ken asks about the process of cutting the review from upwards of 200 pages down to around 50 pages with 49 authors. [00:15:04] Dawn mentions that Dom was part of another paper in 2024 titled “Targeting the mitochondrial stem cell connection in cancer treatment – a hybrid orthomolecular protocol.” Dawn explains that this paper looked at the mitochondrial stem cell connection theory (MSCC), which argues that cancer originates from chronic oxidative phosphorylation insufficiency in stem cells. This insufficiency leads to the formation of cancer stem cells and abnormal energy metabolism ultimately resulting in malignancy. There were 16 research centers and organizations involved in this paper which introduced a hybrid orthomolecular protocol to target the mitochondrial stem-cell connection. Dawn asks Dom to give an overview of MSCC. [00:18:26] Dawn explains that in this paper Dom and his co-authors propose a protocol that would enhance oxidative phosphorylation and inhibit the primary fuels of cancer, glucose and glutamine. This would target both cancer stem cells and metastasis. Dawn asks Dom to explain why this concept is attracting so much interest as a potential therapeutic approach for cancer. [00:20:48] Dawn asks if Dom could discuss the orthomolecular protocol, which is an approach that focuses on preventing and treating diseases by correcting nutritional balances in the body. [00:24:41] Ken asks if the proposed dietary intervention in the orthomolecular approach is different from a standard or typical ketogenic diet. [00:26:48] Ken shifts the discussion to talk about ketone supplements, explaining that Dom recently published a paper titled “Divergent hepatic outcomes of chronic ketone supplementation.” Ken goes on to explain that ketone salts preserve liver health, while some ketone esters and precursors appear to drive inflammation and steatosis. There is a lot of interest in ketone supplementation because they substantially elevate circulating ketones without having to restrict carbohydrates as strictly. The problem, as Ken explains, is that the long-term hepatic safety of ketone supplements remains unclear. In the aforementioned paper, Dom's rodent study evaluated the formulation-dependent impact of chronic ketone supplementation on liver histopathology, inflammatory signaling and systemic biomarkers. Ken asks Dom to discuss this paper and its findings and to give an overview of the various ketone supplements currently available. [00:30:49] Dawn asks Dom to dive into the methods and findings of the rodent study. [00:34:36] Ken asks Dom what his confidence is in the rodent model used in this study, and what are the next step for further research. [00:37:47] Regarding the two different doses given to rats in the study, Ken asks Dom how these doses correlate to doses in humans [00:40:23] Ken mentions that Ben Bikman, who was our guest on episode 143, published a study in February which Dom helped co-author. It examined the effects of ketone supplements on liver function. Ken asks Dom to discuss this study. [00:44:38] Dawn pivots to ask about a joint paper that Dom did with Andrew Koutnik, who was our guest on episode 185, on carbohydrates and physical performance titled “Carbohydrate ingestion on exercise metabolism and physical performance.” Dawn asks Dom to talk about this paper, which showed that a small amount of carbohydrates is sufficient to fuel athletic performance, and how additional carbohydrate intake showed diminishing returns. [00:49:18] Ken follows up on the finding that endurance athletes who rely on carb loading can tend toward pre-diabetes. [00:51:39] Ken asks Dom about the University of South Florida trial that Dom is an advisor for on traumatic brain injury and hyperbaric oxygen therapy. [00:54:41] Dawn mentions that Dom recently had an editorial in Frontiers that gave an overview of the emerging applications of hyperbaric/hyperbaric-oxygen therapy in the treatment of different neurological disorders. Dawn asks Dom what the key points in that editorial were. [00:59:06] Dawn explains that Dom recently gave a lecture at IHMC (available to view on IHMC's YouTube page), on traumatic brain injury and the populations at greatest risk in that context. Dawn asks Dom to give an overview of how an injury to the brain can result in neurometabolic crisis. [01:02:53] Ken asks Dom, excluding occupation demographics, what demographic is most at risk for traumatic brain injury (TBI) and why. [01:04:45] Ken mentions that it is understandable the risk that young people face with TBI due to the activities that young people engage in. Older people, however, have increased risk of TBI from falling as well as an additional age-related biological component that young people are not subject to. Ken asks Dom to elaborate on this. [01:07:12] Dawn mentions that several years ago, Dom and his wife bought some acreage in the countryside and started farming and asks Dom how the farm life is going. [01:07:57] Dawn closes the interview asking how Dom's wife is doing.

Cynthia Donovan sits down with Dr. Jen Gaudiani, physician and author of Sick Enough, to unpack one of the most misunderstood aspects of hypothalamic amenorrhea (HA): you do not need to have an eating disorder to lose your period.Together, they explore how under-nutrition, over-exercise, stress, and biological individuality can disrupt menstrual cycles, even in women who believe they are eating “healthy” and doing everything “right.” Dr. Gaudiani explains the physiology behind hypothalamic amenorrhea, including how the brain downregulates reproductive hormones when energy availability is too low, and why this can happen across a wide spectrum of body types and lifestyles.This episode challenges the harmful belief that you are “not sick enough” to deserve help, and reframes missing periods as a critical early warning sign of metabolic and hormonal adaptation, not failure.You'll also learn how HA often shows up with invisible symptoms like anxiety, perfectionism, cold intolerance, poor sleep, slowed digestion, and low energy, even when labs appear normal. Most importantly, this conversation highlights what recovery actually requires: not perfection, but physiological safety, nourishment, and nervous system support.If you've ever been told your symptoms “aren't serious enough,” or you've struggled with losing your period while being active, disciplined, or high-performing, this episode will help you finally make sense of what your body is trying to communicate.Key Topics Covered:Why hypothalamic amenorrhea can occur without an eating disorderThe role of energy availability in menstrual health“Sick enough” thinking and why it delays recoveryInvisible symptoms of under-nutrition (even with normal labs)Metabolic adaptation and why the body slows downHow the brain prioritizes survival over reproductionBone health risks and hormonal suppression in HAWhy comparison to others is misleading biologicallyThe identity shift required for full recoveryHow to talk to providers who may not understand HASupporting adolescents and breaking generational diet culture patternsAbout the Guest:Dr. Jen Gaudiani is a physician specializing in eating disorders and complex medical complications of under-nutrition. She is the author of Sick Enough: A Guide to the Medical Complications of Eating Disorders, now in its updated second edition. (https://amzn.to/4waPFVf)She is the founder of the Gaudiani Clinic, where she and her team support patients across the United States with eating disorders, hypothalamic amenorrhea, and complex medical presentations related to energy deficiency.

The new 2026 AHA/ACC/ADA/ASN Cardiovascular–Kidney–Metabolic (CKM) Guideline reframes chronic disease through a unified lens connecting obesity, diabetes, chronic kidney disease, and cardiovascular disease. Key themes: ✅ CKM staging across the life course ✅ PREVENT risk assessment for personalized care ✅ Early detection of kidney and cardiometabolic risk ✅ Lifestyle and weight management as foundational therapy ✅ Evidence-based use of SGLT2 inhibitors and GLP-1–based therapies ✅ Team-based, patient-centered care A landmark step toward integrated prevention and better long-term outcomes. #Cardiology #Nephrology #Diabetes #Obesity #CKM #PreventiveCardiology #MedicalPodcasts #PrecisionMedicine #HeartFailure #KidneyDisease

In Part 2, Naveed Sattar discusses obesity, ectopic fat, and cardiovascular risk. Learn how imaging and biomarkers are improving risk identification, why metabolic dysfunction matters beyond BMI, and how GLP-1 therapies are reshaping obesity and cardiovascular care.  Timestamps:  0:56 – Ectopic fat  11:44 – Metabolic dysfunction  13:42 – GLP-1 receptor agonists  19:05 – Mechanistic insights  21:31 – Societal issues 

Send Vanessa a Text MessageA special listener discount is available for Mara Labs products featured in this episode: Explore Mara Labs (Code is VANESSA)If you enjoy the podcast and want to support Vanessa's work, you can do so here: Buy Me a Coffee – Intentionally WellIn this episode, I'm joined by David Roberts, founder of Mara Labs, for a conversation exploring cellular health, modern environmental stressors, and the body's natural resilience systems.David's journey into this space began after his late wife Mara's cancer diagnosis, which led him to deeply explore plant-based compounds and how they interact with cellular protection and repair mechanisms. That path eventually led to the development of BrocElite, a stabilized sulforaphane supplement designed to support detoxification pathways, mitochondrial function, and overall cellular resilience.We discuss topics including sulforaphane, oxidative stress, detoxification and autophagy pathways, metabolic health and GLP-1 signaling, genetic variability such as MTHFR and COMT, and how modern environmental exposures like microplastics may be impacting overall health.This is a wide-ranging conversation aimed at helping make complex biology more understandable and grounded in real-life application.Key Topics Covered: Sulforaphane and cellular defense systems  Detoxification pathways and autophagy  Mitochondrial health and oxidative stress  Modern environmental exposures (including microplastics)  Metabolic health and GLP-1 signaling  Genetic variability (MTHFR / COMT) and sensitivity  Why some people feel more reactive in today's environment Sulforaphane and pet health BrocElite and Mara Labs story Connect with David:Mara Labs on InstagramExplore Mara LabsConnect with Vanessa and the podcast: IWP Website: Intentionally Well PodcastIWP Recommended ProductsPodcast on InstagramVanessa on InstagramPodcast on YouTubeVanessa on TikTokVanessa on XEmail: intentionallywellpodcast@gmail.comSupport the showThis episode is for informational purposes only. Please consult a trusted health practitioner for individual concerns.

ReferencesNature Reviews Genetics 2019. volume 20, pages 657–674Int.J. Mol. Sci. 2014, 15, 16848-16884Nat Cell Biol. 2019 Mar; 21(3): 397–407.Cell. 2006. Volume 126, Issue 3, 11 August Pages 503-514Circ Res. 2018 Sep 14; 123(7): 868–885. DNA Repair (Amst) 2019 Nov:83:102640Guerra,DJ.2026. Unpublished LecturesSchubert, F. 1826. Symphony 9 in C Major D.944https://music.youtube.com/watch?v=TPpvJnwf5BU&si=pkO5rekCvtw9AHNv

What if fatigue, inflammation, poor recovery, hormone issues, bloating, brain fog, and "feeling stuck" are not simply about doing more… …but about impaired FLOW inside the body? In Part Three of The Terrain First Series: Flow, Signals & the Future You, Debbie Potts dives deep into the physiology behind her F.L.O.W. Foundation™ and explains why healing depends on movement, communication, oxygen delivery, drainage, and nervous system safety. In this episode, you'll learn: What F.L.O.W. stands for: Neural FLOW Lymphatic FLOW Oxygen FLOW Waste & Bile FLOW Why the nervous system controls digestion, recovery, and repair How chronic stress physiology may impair stomach acid, bile flow, motility, and mitochondrial function Why the lymphatic system is one of the most overlooked systems in modern health The connection between oxygen delivery, nitric oxide, mitochondria, and metabolic resilience Why "Drainage Before Detox" matters How sluggish bile flow may contribute to hormone recirculation, inflammation, and digestive dysfunction Why high performers often stay stuck in survival physiology despite "doing everything right" How the body constantly asks: Am I safe? Can I recover? Should I build or defend? Debbie also connects the dots between: The Cell Danger Response Vagal tone Mitochondrial communication Inflammation signaling Metabolic flexibility PNOĒ metabolic testing Terrain First physiology The FutureYou Blueprint™ This episode is a deep dive into why the body cannot heal efficiently when information, oxygen, nutrients, hormones, immune signals, and waste cannot move through the system properly. Because healing is not about forcing the body. It's about creating the conditions where the body finally feels safe enough to repair. Learn more about coaching, PNOĒ metabolic testing, and The FutureYou Blueprint™ at: https://debbiepotts.net Subscribe to Coach Debbie Potts on YouTube: https://www.youtube.com/@coachdebbiepotts #TerrainFirst #FutureYouBlueprint #FlowFoundation #VagusNerve #Mitochondria #MetabolicHealth #FunctionalMedicine #GutHealth #HormoneHealth #PNOE #Longevity #CoachDebbiePotts #CellDangerResponse #MetabolicFlexibility #HealthyAging

FREE RESOURCE:  Click the link and see if the SHED METABOLIC RESET PROGRAM is a good fit for you!  FREE RESOURCE:  Try our Protein Calculator, see how much you might require daily!    In this episode of Wild Medicine, Dr. Michelle and Dr. Tara discuss the critical issue of nutrition education and its impact on health.  They explore how many individuals lack proper guidance on eating, leading to widespread metabolic health issues.  The conversation delves into the importance of understanding dietary patterns, the role of stress and hormones, and the necessity of consistency in eating habits.  They emphasize the need for a structured framework to promote safe and effective eating practices, ultimately aiming to empower individuals to take control of their health.  In this conversation, Dr. Tara and Dr. Michelle discuss the importance of simplifying nutrition to reduce mental load, emphasizing the balance of carbs and protein, the benefits of front-loading calories, and the critical role of fiber in digestive health.  They highlight the need for individuals to take radical responsibility for their health and empower themselves through understanding nutrition.  The discussion is rooted in clinical insights and personal experiences, aiming to provide practical advice for listeners.   Takeaways Nobody taught us how to eat properly, leading to confusion. Creating clarity in nutrition is essential for empowerment. Metabolic syndrome has significantly increased in recent years. 1.54 billion adults are affected by metabolic syndrome. Fundamental nutrition education is lacking in society. Routine and consistency in eating are crucial for health. Carbohydrates often dominate meals, overshadowing protein. Fiber intake is typically much lower than recommended levels. Eating healthy can feel radical in today's food culture. Safety and predictability in eating lead to better health outcomes. Reducing mental load around food choices is crucial. A one-to-one ratio of carbs to protein is beneficial. Front-loading calories can enhance energy levels throughout the day. Fiber plays a significant role in digestive health and overall well-being. Tracking food intake can help identify dietary patterns. Empowerment comes from understanding and taking responsibility for health. Simple dietary changes can lead to significant improvements in health. Meal prep can simplify daily nutrition decisions. Carbs should be included in a healthy diet, focusing on fiber-rich options. Radical responsibility is key to achieving health goals.   Chapters 00:00 Introduction to Wild Medicine and Eating Habits 03:49 Understanding the Impact of Uninformed Eating 06:52 The Metabolic Health Crisis 10:36 Fundamentals of Nutrition and Eating Patterns 16:07 The Importance of Consistency in Eating 20:26 The Role of Stress and Hormones in Eating 29:49 Framework for Safe and Consistent Eating 30:58 Simplifying Nutrition: Reducing Mental Load 32:28 The Importance of Carbs and Protein Ratios 34:15 Front-Loading Calories for Better Energy 38:50 The Role of Fiber in Digestive Health 41:43 Taking Radical Responsibility for Health 49:03 Empowerment Through Understanding Nutrition   Stay Wild. Connect with Dr. Tara on INSTAGRAM Connect with Dr. Michelle on INSTAGRAM This episode is brought to you by: www.MichellePeris.com Ready to reclaim your Wild? JOIN THE WAITLIST Learn more about The Poppy Clinic: www.poppyclinic.com Is Naturopathic Medicine for you: LEARN MORE HERE Take our HORMONE QUIZ Are you a clinician looking for more impact? START HERE

References eLife 2020;9:e55828 DOI:10.7554/eLife.55828Cell Death Discovery2024.  10, Article number: 231 Int J Mol Sci. 2017 Sep 15;18(9):1979Guerra, DJ.2026. Unpublished lecturesHunter/Lesh 1970. Box of Rainhttps://open.spotify.com/track/7x2xjJV3YAPeLQJ7u3Kjet?si=37646e5c42584619

The newborn with a new onset (some kind of) metabolic disease is a rare event in the Pediatric ER. Add that to the fact that there are so many different types of diseases with so much basic science to remember and you got a pretty bad situation in your hands. That is why I invited Dr. Austin Larson an Associate Professor of Pediatrics-Clinical Genetics and Metabolism on the show to discuss how we can do a better job identifying and treating those children.    

Can I restart my GLP-1? The answer is yes — but it requires a strategic plan.  In this episode I'm walking you through exactly what happens to your body when you restart a GLP-1, why the timing of your break matters more than you think, how to restart safely without landing yourself in misery, the biggest mistakes I see patients make, and how to get back on track without shame or guilt. Restarting doesn't have to mean starting completely over. But how you restart matters. Listen now!   Episode Highlights: Why restarting at your previous dose will make you seriously sick What happens to your hunger, cravings, and fullness signals when you restart How long you've been off determines your restart dose The critical question that changes everything: weeks vs. months off Why weight regain after stopping is biology, not failure 3 practical strategies to minimize side effects and rebuild tolerance How to stay mentally on track without shame or comparison   Connect with Dr. Alicia Shelly: Website | drshellymd.com Facebook | www.facebook.com/drshellymd Instagram | @drshellymd Linked In | www.linkedin.com/in/drshellymd Twitter | @drshellymd   About Dr. Alicia Shelly Dr. Alicia Shelly was raised in Atlanta, GA. She received her Doctorate of Medicine from Case Western Reserve University School of Medicine in Cleveland, OH.  Dr. Shelly has been practicing Primary Care and Obesity medicine since 2014.  In 2017, she became a Diplomat of the American Board of Obesity Medicine. She is the lead physician at the Wellstar Medical Center Douglasville. She started a weekly podcast & Youtube channel entitled Back on Track: Achieving Healthy Weight loss,  where she discusses how to get on track and stay on track with your weight loss journey. She has spoken for numerous local and national organizations, including the Obesity Medicine Association, and the Georgia Chapter of the American Society of Metabolic and Bariatric Surgeons. She has been featured on CNN, Fox 5 News, Bruce St. James Radio show, Upscale magazine, and Shape.com. She was named an honoree of the 2021 Atlanta Business Chronicle's 40 under 40 award. She also is a collaborating author for the, "Made for More: Physician Entrepreneurs who Live Life and Practice Medicine on their own terms''.   Resources: FREE! Discover the 5 Reasons Your Weight-Loss Journey Has Gotten Derailed (And How To Get Back On Track!)

ReferencesJ Pineal Res. 2017 Sep 6;63(4):e12440Nature Reviews | Cancer Reviews2019. 19 | AUGUST 2019 :pp. 439J Exp Clin Cancer Res 2022. 41, 268.Front. Genet., 11 March 2015 Sec. Cancer Genetics Volume 6 - 2015 | https://doi.org/10.3389/fgene.2015.00094 Pathol Oncol Res 2022 Aug 19:28:1610401Guerra, DJ.2026.Unpublished LecturesPorter, C. I1944. Love You Bing Crosbyhttps://music.youtube.com/watch?v=U2Ehu42-mik&si=tkpg8dJxk2TdBvQPAhlert and Turk. 1928. 1944 I'll Get By. Harry James and Orchestrahttps://music.youtube.com/watch?v=8KhO3g5kY0c&si=fXWDc4ZheJ658A1xBeethoven, LV. 1804. Symphony V. C Minor Op 67https://music.youtube.com/watch?v=q_kw904K2bw&si=qDRCnK5UVDi1-9w2

ReferenceseLife 2020;9:e55828 DOI:10.7554/eLife.55828 Int J Mol Sci 2017 Sep 15;18(9):1979 Genes (Basel) 2021 Aug 31;12(9):1370Guerra, DJ.2026. Unpublished LecturesDylan, B. 1964. My Back Pages. Byrdshttps://open.spotify.com/track/1yexhSDARSLVvRCBU3wDAm?si=56d728e0cdcd42a4Winwood/Capaldi, 1970. Empty Pages. Traffichttps://open.spotify.com/track/4UhB17vQsTP0qM9grc4ZUi?si=636948e5ac7f457eSeger,B. 1972. Turn the Page.https://open.spotify.com/track/3P2XAL8UpPBM3nfvuEjHHE?si=47130e77f3ae4729

Why does exercise feel harder now—even though you're still training? Why does recovery take longer? Why are you doing "all the right things" but still struggling with fatigue, muscle loss, slower metabolism, or reduced performance? In Part 4 of my Terrain First Series, we dive into the O in the FLOW Method: O = Oxygen Flow Because Oxygen Flow is about much more than breathing. It influences: ✓ Energy production (ATP) ✓ Recovery capacity ✓ Muscle building and repair ✓ Mitochondrial health ✓ Nervous system regulation ✓ Nitric oxide production ✓ Metabolic flexibility ✓ Healthy aging and resilience In this episode, we explore: • What Oxygen Flow actually means • Why exercise feels harder after 40 • The connection between oxygen, mitochondria, and energy production • How nitric oxide affects circulation and performance • Why the vagus nerve influences breathing and recovery • Signs your Oxygen Flow may be impaired • Practical strategies to improve oxygen delivery, utilization, recovery, and resilience If you're an active adult, endurance athlete, high performer, or someone trying to improve metabolism and age stronger—not slower—this episode is for you. Because sometimes the problem isn't motivation. Sometimes the problem is physiology. Learn more about PNOĒ metabolic testing, coaching, and The FutureYou Blueprint: www.debbiepotts.net COMMENT BELOW: Have you noticed recovery getting harder as you age? #Metabolism #Recovery #HealthyAging #MidlifeFitness #VO2Max #Mitochondria #Hormones #Perimenopause #MenopauseFitness #PNOE #Fatigue #EnduranceAthlete #MuscleHealth #Biohacking #FutureYou

ReferencesOpen Heart. 2022 Dec 15;9(2):e002171.J Pineal Res. 2017 Sep6;63(4):e12440Int J Mol Sci. 2022 Feb 8;23(3):1905Guerra, DJ. 2026 Unpublished LecturesMozart, WA.1785/1786. Piano Concerti 22&23 . E flat and A major K.282 and 488,https://music.youtube.com/playlist?list=OLAK5uy_lkoFk_2RmT1POq5-0idPoWwAVX5U_yOAk&si=p-m9VoElWiZRURrS

In this solo episode, Vanessa breaks down the biggest takeaways from her conversation with Daniel R. Moore, Professor of Muscle Physiology at the University of Toronto. This episode is a deep dive into muscle protein synthesis, protein intake, fat loss, aging, and why preserving lean mass is one of the most important factors for long-term metabolic health and body composition. Check out the Protein-Sparing Modified Fasting Library at ketogenicgirl.com and use code VANESSA for 20% off. Vanessa explains: What muscle protein synthesis actually is Why muscle is constantly remodeling Why low-protein dieting can accelerate muscle loss How calorie deficits increase protein requirements Why resistance training is the most powerful muscle-preserving signal The truth about the "protein per meal ceiling" Why whey protein is so effective What anabolic resistance really means Why movement and exercise become increasingly important as we age How menopause impacts muscle loss and metabolic health This episode also explores why muscle is not just aesthetic tissue — it is metabolic, protective, and longevity-promoting tissue. In This Episode Muscle protein synthesis explained Protein turnover & muscle remodeling Why low-protein diets backfire Protein needs during fat loss Resistance training & muscle preservation The protein ceiling debate Whey protein & leucine Anabolic resistance & aging Menopause & muscle loss Protein timing & meal distribution Fat loss vs muscle loss Metabolic health & longevity The PSMF Library is officially live

Dave Feldman is the originator of the Lipid Energy Model and the Lean Mass Hyper-Responder (LMHR) phenotype, reshaping how we understand cholesterol and metabolism. As founder of the Citizen Science Foundation, he leads groundbreaking research into lipid metabolism, cardiovascular health, and metabolic responses to ketogenic diets. Dave's work includes spearheading the Keto-CTA study, which investigates how diet influences plaque progression and regression using advanced imaging. A passionate advocate for open science, he engages with researchers, clinicians, and the public to challenge assumptions, foster transparency, and drive innovative, data-driven insights into cardiovascular risk and human metabolism. INSTAGRAM: https://www.instagram.com/realdavefeldman TWITTER / X: https://x.com/realdavefeldman LINKEDIN: https://www.linkedin.com/in/dave-feldman/ YOUTUBE: https://www.youtube.com/@realDaveFeldman https://www.youtube.com/@feldmanprotocol Timestamps: 00:00 Trailer 00:37 Introduction 05:36 Experimenting with diet and risk decisions 08:03 Understanding the lipidary model 11:26 Early lipid conference predictions 15:56 Discussing blood glucose in athletes 17:34 Triglyceride delivery issues 21:05 Experimenting with lipid energy models 23:29 Positive feedback on keto documentary 29:42 Discrepancies in data analysis 32:51 Paper retraction and investigation process 36:47 LDL and health studies 38:33 Analyzing plaque level accuracy 41:51 Study eligibility criteria 47:29 Rethinking study design choices 48:40 The lipid hypothesis study 52:11 Metabolic health improvements 54:21 Where to watch The Cholesterol Code documentary Join Revero now to regain your health: https://revero.com/YT Revero.com is an online medical clinic for treating chronic diseases with this root-cause approach of nutrition therapy. You can get access to medical providers, personalized nutrition therapy, biomarker tracking, lab testing, ongoing clinical care, and daily coaching. You will also learn everything you need with educational videos, hundreds of recipes, and articles to make this easy for you. Join the Revero team (medical providers, etc): https://revero.com/jobs ‪#Revero #ReveroHealth #shawnbaker  #Carnivorediet #MeatHeals #AnimalBased #ZeroCarb #DietCoach  #FatAdapted #Carnivore #sugarfree Disclaimer: The content on this channel is not medical advice. Please consult your healthcare provider.

In this episode the guys break down diet breaks — what they actually are, how they differ from just going off your diet, and why the science supports using them on any fat loss plan. They cover the five key benefits backed by studies: slowing metabolic adaptation, improving workout recovery and energy, preserving muscle, reducing mental fatigue, and why planning is everything. They also make the case for why most people shouldn't try to navigate diet breaks alone and how a coach changes the outcome entirely. 50% off Nutrition Coaching Call — ⁠https://mindpumpnutrition.com⁠ Code: POD50 SPONSORS Seed Daily Synbiotic — ⁠https://seed.com/mindpump⁠ Code: 25MINDPUMP — 25% off first month MAPS Summer Sale — ⁠https://mapsfitnessproducts.com⁠ Code: SUMMER40 — 40% off everything (programs, bundles & mods) — June 1–14 only LINKS Mind Pump Store: ⁠https://mindpumpstore.com⁠ Maps Fitness Products: ⁠https://mapsfitnessproducts.com⁠ Instagram: @mindpumpmedia   SPOTIFY TIMESTAMPS 0:00 - Intro 1:48 - What is a diet break? (And what it's not) 4:28 - Benefit #1: Metabolic adaptation — why your metabolism stops responding and how diet breaks help 10:29 - Benefit #2: Workout recovery and energy — why deficits kill performance and diet breaks fix it 12:27 - Benefit #3: Muscle preservation — what the data shows about fat loss vs. muscle loss 15:05 - Benefit #4: Mental fatigue — the number one reason diets fail long term 18:25 - Benefit #5: Why you must plan it — and why doing it alone usually goes off the rails 23:33 - 50% off nutrition call with a Mind Pump coach — mindpumpnutrition.com code POD50

Have you ever wondered how to enjoy your favorite carbohydrates without completely ruining your fat-loss progress or crashing your energy levels halfway through the day? This episode compiles previous interviews regarding how to fuel the body, burn fat, and use carbohydrates. Rachel Gregory shares her transition from keto to reintroducing carbohydrates to fuel training and performance. Robert Sikes explains how adherence to keto develops metabolic machinery. I share my framework on carb back-loading to manage glycogen stores. Consuming carbohydrates post-workout and at dinner keeps blood sugar from spiking, maintains fat adaptation, and shifts the body into a rest state. Keeping carbohydrates under 100 grams lets you utilize fat for energy during the day and use carbohydrates for recovery. Key takeaways Metabolic flexibility allows your body to burn fat for energy during low-impact activities and seamlessly switch to burning carbohydrates during workouts. Becoming fat-adapted typically requires a minimum of three to four weeks in a low-carbohydrate state. Reintroducing carbohydrates should be done slowly, prioritizing sources like potatoes, rice, and fruits over processed foods. Carb back-loading involves eating your carbohydrates post-workout and at dinner to replenish muscle glycogen without storing it as fat. Consuming carbohydrates in the evening helps transition the nervous system into a parasympathetic, rest-and-digest state for sleep. Strict adherence to a single dietary protocol like keto can maximize the efficiency of your body's metabolic machinery. A low-carbohydrate lifestyle can be defined as consuming under 100 grams of carbohydrates per day. Resources Website: https://milliondollarbodylabs.com/ Book: The Million Dollar Body Method by Nate Palmer Lean Energy Stack: https://milliondollarbodylabs.com/pages/lean Instagram: @_milliondollarbody

Send us Fan MailMany women are doing everything "right."They're eating healthy, taking supplements, exercising, seeing specialists, getting labs done… and yet they still feel exhausted, inflamed, anxious, hormonally imbalanced, unable to lose weight, struggling with sleep, gut issues, thyroid symptoms, autoimmune conditions, or fertility challenges.So what if the problem isn't a lack of effort?What if the real issue is happening further upstream?In this fascinating episode of The It's Hertime Podcast, Cody sits down with Deborah Maragopoulos, FNP—better known as "The Hormone Queen"—to discuss the powerful role of the hypothalamus, a small but critical part of the brain that helps regulate hormones, metabolism, sleep, digestion, stress response, immunity, fertility, body temperature, and much more.Drawing from more than 30 years of clinical experience working with complex chronic illness cases, Deborah explains why so many women feel dismissed, why normal labs don't always mean optimal health, and why addressing symptoms alone often fails to create lasting healing.Together, Cody and Deborah explore the connection between stress, the nervous system, thyroid function, gut health, autoimmunity, metabolism, and hormone balance—and what women can do to support the body's communication systems naturally.If you've ever felt like you've tried everything and still don't feel like yourself, this conversation may connect some important dots.In this episode, we discuss:• What the hypothalamus is and why it matters • Why women can feel terrible despite "normal" lab results • The connection between stress and hormone signaling • How nervous system overload impacts metabolism and health • Why thyroid symptoms persist for some women even on medication • The relationship between gut health, inflammation, and hormones • Hashimoto's, autoimmune disease, and chronic stress patterns • Weight loss resistance, fatigue, brain fog, anxiety, and sleep disruption • Why so many women feel stuck despite doing all the right things • Practical ways to support the body's communication systems naturallyConnect with Deborah Maragopoulos:Instagram: @deborahmaragopoulosfnp https://www.instagram.com/deborahmaragopoulosfnp/YouTube: https://www.youtube.com/channel/UCTwDjUWkxsANSmh2wF5ltSgWebsite: https://genesisgold.comFree Gift for It's Hertime Listeners: https://thehormonequeen.com/hertimeConnect with Cody:Instagram: https://www.instagram.com/codyjeansanders/Mixhers: Use Code: Cody for 15% offIf this episode helped you, please subscribe, leave a review, and share it with a friend who needs to hear it. Your support helps us reach more women with empowering health education.Did you learn something new today? Be sure to subscribe to this podcast and share this episode with all the girls you love. We would appreciate it if you'd also leave us a rating and review on iTunes.Want to join our Mixhers Girl community and keep this conversation going? We'd love to hear your thoughts, feelings and experiences! Join us HERE!Join Mixhers email list and be the first to have access to new products and be the girl in the know!Follow Cody Instagram:@codyjeansanders

Dr. Paul Reynolds has spent his career studying what he calls “two heads of the same beast”: inflammation and glycation — two interlocking processes that may help explain why so many chronic diseases are connected, even when they are treated as separate conditions.Dr. Reynolds is a professor and research scientist at Brigham Young University whose NIH-funded research program studies inflammation, lung biology, glycation, and the AGE/RAGE receptor system that links metabolic and environmental stressors to disease throughout the body.In this episode, Dr. Reynolds traces the glycation cascade from early sugar-protein reactions to advanced glycation end-products, or AGEs, and explains how the RAGE receptor can act as a self-perpetuating accelerant for inflammation. He also breaks down why the brain may be uniquely vulnerable to glucose dysregulation, how diesel exhaust and tobacco smoke can create AGE-like structures that bind the same inflammatory receptors, and how the glyoxalase defense system helps neutralize damage before it becomes permanent.Questions Answered in This Episode:Can breathing polluted air trigger some of the same inflammatory pathways as excess sugar exposure?Is browned food a real glycation concern, or is the bigger issue what happens inside the body when glucose stays elevated?Why is the brain especially vulnerable to glucose dysregulation?How does fasting help the body reduce glycation and inflammatory burden?What do people need to understand about sugar substitutes like allulose and xylitol when it comes to glycation?How should we approach kids' nutrition if glycation and inflammation can begin early in life?Is glycation damage reversible, and where does the body draw the line?This conversation offers a mechanistic map connecting cardiovascular disease, neurodegeneration, metabolic dysfunction, environmental exposures, and visible aging back to two upstream processes many patients never hear named in a clinical visit.Find the Meet Consumption and Cognitive Health paper here.Sign up for his upcoming Q&A on The Metabolic Initiative here.Find Dr. Reynolds online:InstagramFacebookX.comYoutubeLinkedInTikTokSpecial thanks to the sponsors of this episode:✅ Toups and Co – Get 15% off your first order with code METABOLIC here.✅ Fatty15 – Get 15% off a 90-day Starter Kit with code METABOLICLINK here✅ ZocDoc - Find and instantly book a top-rated doctor hereIn every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel!Find us on social: InstagramFacebookYouTubeLinkedInPlease keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.

Sugar Is Not a Treat. It's a Metabolic Event.Most people think sugar is just calories.It's not.It's a signal.And every time it enters your body, it triggers a cascade that affects nearly every organ system.In this episode of The Thrive Forever Fit Show, Jay Nixon breaks down exactly what happens physiologically when you consume sugar, even in small amounts, and what repeated exposure does over time.This is not about fear.It's not about perfection.It's about understanding how the system works.Because when you understand the mechanism, you stop blaming yourself and start making strategic decisions.In This Episode, Jay Covers:The Immediate Response to SugarDopamine activation in the brainBlood glucose elevationInsulin release and cellular energy signalingWhy this is normal in small, infrequent amountsGlucose vs Fructose: The Critical DifferenceMost people think sugar is sugar. It's not.Jay explains the metabolic difference between:Glucose, which raises blood sugar and triggers insulinFructose, which bypasses insulin regulation and is processed almost exclusively in the liverYou'll learn why:Glucose stresses blood sugar controlFructose stresses the liverCombined, they create a dual metabolic burdenThe Liver: Ground Zero for Metabolic DysfunctionIn this episode, Jay walks through how excess fructose drives:De novo lipogenesisFat accumulation in the liverElevated triglyceridesVisceral fat storageInsulin resistance progressionNon-alcoholic fatty liver disease is not random.It is repetitive exposure.The Systemic Effects of Chronic Sugar ExposureJay explains how repeated sugar intake impacts:The PancreasChronic insulin outputBeta cell stressCompensation and eventual dysfunctionThe Cardiovascular SystemElevated triglyceridesSmall dense LDL particlesGlycation of proteinsVascular agingThe BrainEnergy instabilityMood fluctuationCognitive risk linked to insulin resistanceHormonal HealthCortisol reactivityLeptin and ghrelin disruptionTestosterone suppression in menOvarian dysfunction in womenThis is not about weight gain.This is about systemic metabolic stress.The Real Issue: Frequency, Not Occasional ExposureOne dessert does not destroy your metabolism.Three to five exposures per day for years will.Metabolic dysfunction develops through repetition:Repeated spikes.Repeated insulin surges.Repeated liver overload.Repeated inflammation.Eventually, the system adapts in ways you don't want.The Empowering MessageYou are not broken.Your metabolism is responding exactly as designed.The solution is not elimination.It is resilience.In this episode, Jay outlines the fundamentals of rebuilding metabolic strength:Protein at every mealDaily fiber intakeStrength training to improve insulin sensitivityProtecting sleepReducing unnecessary sugar frequencyWhen metabolic health is strong, sugar becomes something your body can tolerate occasionally instead of something that drives dysfunction.Why This Episode MattersSugar is not just a treat.It is a biochemical event.When you understand what it does inside your body, you gain leverage.And leverage changes behavior.Episode 333 is your wake-up call to stop thinking about sugar emotionally and start thinking about it metabolically.

In this solo episode, I'm breaking down one of the most misunderstood topics in the fitness space your metabolism. If you feel like your body isn't responding the way it used to, your energy is low, your hunger is all over the place, or fat loss feels harder than ever, this episode is for you.I dive into the real reasons your metabolism may have slowed down including chronic dieting, under-eating, lack of muscle mass, low activity levels, stress, poor recovery, and the long-term effects of trying to “eat as little as possible” to lose weight. I also explain the difference between an actually damaged metabolism versus metabolic adaptation and what's really happening inside your body.Most importantly, we talk about what you can do to support and improve your metabolism in a realistic, sustainable way. From building muscle and increasing daily movement to properly fueling your body and improving recovery, this episode gives you practical strategies you can start applying now.If you're tired of feeling stuck and want to understand how to work with your body instead of against it, this episode is packed with information you don't want to miss.Follow me here:Instagram: @NicoleFerrierFitnessCoaching: www.nicoleferrierfitness.com

Could your constant fatigue, weight gain or brain fog be traced back to one small gland? On Believer's Voice of Victory, Courtney Copeland, Dr. Don and Mary Colbert uncover why it's essential to know your numbers when it comes to your thyroid. Learn how this powerful “thermostat” impacts nearly every system in your body and why so many people are missing the warning signs. This episode will open your eyes to what might really be holding you back from feeling your best.Mentioned in this episode:BVOV Podcast Link HubBVOV Podcast Link HubBVOV Podcast Link HubBVOV Podcast Link HubBVOV Podcast Link Hub

Could your constant fatigue, weight gain or brain fog be traced back to one small gland? On Believer's Voice of Victory, Courtney Copeland, Dr. Don and Mary Colbert uncover why it's essential to know your numbers when it comes to your thyroid. Learn how this powerful “thermostat” impacts nearly every system in your body and why so many people are missing the warning signs. This episode will open your eyes to what might really be holding you back from feeling your best.Mentioned in this episode:BVOV Podcast Link HubBVOV Podcast Link HubBVOV Podcast Link HubBVOV Podcast Link HubBVOV Podcast Link Hub

The Nurses Report on America Out Loud with Gail Macrae, BSN, RN – Ethan Okunas explains how sunlight, darkness, meal timing, and movement restore circadian alignment, improve mitochondrial function, reduce hunger, and support lasting metabolic health beyond calories, macros, or clean eating, helping people counter obesity, autoimmunity, fatigue, and insulin resistance naturally daily...

There's more to mental health than pills, prescriptions, and counseling. In this episode, I dive deep into the often-overlooked connection between major depressive disorder and neuroinflammation. While many focus solely on serotonin as the "happiness chemical," I'll reveal how chronic inflammation can actually "steal" the raw materials your brain needs to produce it. We'll unpack the biochemistry of how pro-inflammatory cytokines create a "fork in the road" for tryptophan, shifting it away from serotonin and toward neurodegenerative molecules that impact your memory, focus, and sense of reward.Topics discussed: - Link between systemic inflammation and major depressive disorder- Why genetics matter - Inflammation hijacking- Understanding cytokines- Physical changes in your brain- Anti-inflammatory effects - Steps to identify and mitigate inflammation ---------- ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠My Live Program for Coaches: The Functional Nutrition and Metabolism Specialization ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠www.metabolismschool.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠---------- [Free] Metabolism School 101: The Video Series⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠http://www.metabolismschool.com/metabolism-101⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠----------Subscribe to My Youtube Channel: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://youtube.com/@sammillerscience?si=s1jcR6Im4GDHbw_1⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠----------⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Grab a Copy of My New Book - Metabolism Made Simple⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠---------- Stay Connected: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Instagram: @sammillerscience⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Youtube: SamMillerScience⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Facebook: The Nutrition Coaching Collaborative Community⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠TikTok: @sammillerscience⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠----------“This Podcast is for general informational purposes only and does not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast and the show notes or the reliance on the information provided is to be done at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment and is for educational purposes only. Always consult your physician before beginning any exercise program and users should not disregard, or delay in obtaining, medical advice for any medical condition they may have and should seek the assistance of their health care professionals for any such conditions. By accessing this Podcast, the listener acknowledges that the entire contents and design of this Podcast, are the property of Oracle Athletic Science LLC, or used by Oracle Athletic Science LLC with permission, and are protected under U.S. and international copyright and trademark laws. Except as otherwise provided herein, users of this Podcast may save and use information contained in the Podcast only for personal or other non-commercial, educational purposes. No other use, including, without limitation, reproduction, retransmission or editing, of this Podcast may be made without the prior written permission of Oracle Athletic Science LLC, which may be requested by contacting the Oracle Athletic Science LLC by email at ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠operations⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@sammillerscience.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. By accessing this Podcast, the listener acknowledges that Oracle Athletic Science LLC makes no warranty, guarantee, or representation as to the accuracy or sufficiency of the information featured in this Podcast."

The Senate showdown, new testing for women's metabolic problems, corporate underwriting of gender-transitions, and the late Dave Mason's peak. Plus, Daniel Suhr on the hidden cost of lawfare, a repurposed Barbie camper, and the Thursday morning newsSupport The World and Everything in It today at wng.org/donateAdditional support comes from I Witness: Ride to Freedom. Three friends. One simulation. Trapped in history during the Freedom Rides. Now on all major platforms or iwitnesspod.comFrom PEACE International... Serving South Sudan's refugees by educating children, empowering women and equipping pastors.  PeaceINT.orgAnd from Reformation Bible College, where theology shapes every calling. More at discover.ReformationBibleCollege.org