Metagenics Institute Podcast

Professor Roy Taylor is the Director of Newcastle Magnetic Resonance Centre and an honorary consultant Physician. He specialises in the application of magnetic resonance spectroscopy to clinical medicine, metabolic research in diabetes, as well as teaching in diabetes and obstetric medicine, and much more. Professor Taylor is also the author of books Life Without Diabetes and Your Simple Guide to Reversing Type 2 Diabetes. In this episode, Nathan talks to Roy about the significance of muscle insulin sensitivity, your personal fat threshold, GLP-agonists and most importantly, how caloric restriction can reverse diabetes. Professor Taylor's passion for the topic is palpable and makes for a great podcast! *Highlights * Why excess caloric intake matters (3:50) Introduction to the twin cycle hypothesis (7:00) The significance of visceral fat (16:35) Muscle insulin sensitivity (19:10) Your personal fat threshold (26:35) Reversing diabetes with caloric restriction (32:40) Caloric restriction in action (43:40) GLP-1 agonists (54:00) Research on the horizon (1:00:00) Useful links and resources: The study Prof Taylor mentions: Very Low-Calorie Diet and 6 Months of Weight Stability in Type 2 Diabetes: Pathophysiological Changes in Responders and Nonresponders - https://care.diabetesjournals.org/content/41/6/1321.1 Review article by Prof Taylor: Type 2 diabetes and remission: practical management guided by pathophysiology - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8247294/ Prof Taylor's books: https://www.amazon.com/Professor-Roy-Taylor/e/B0831TXHKF%3Fref=dbsamngrwtscns_share

Dr Taylor Krick is a Chiropractor and Functional Medicine Practitioner practicing from the Washington Wellness Centre in Washington, Illinois. He has a special interest in educating people to help take control of their health, and in this episode, he and Nathan discuss the use of transcutaneous vagal nerve stimulation (tVNS) to aid healing. Dr Krick provides a lesson on the vagal nerve as well as the use of tVNS in practice, including who may be suited to this method of therapy and specific information regarding the use of devices. Tune in to learn how to improve your or your patients' vagal tone for optimal health and wellbeing. Highlights About the wanderer nerve (9:00) Accessing the vagal nerve (19:20) Transcutaneous vagal nerve stimulation in practice (30:00) Discussion regarding the research landscape (38:00) Treating chronic illness (43:00) Using a transcutaneous vagal nerve stimulation device in clinic (49:30) Where you can find Dr Taylor Krick (58:00) Useful links and resources Dr Taylor Krick's clinic: Washington Wellness Center - https://www.washwellnesscenter.com/ Wellness Washington Center educational videos - https://www.washwellnesscenter.com/videos

With over 20 years of experience in the clinic and the ‘classroom' as one of the top practitioners and educators in integrative nutrition and health, Rachel Arthur has attracted a large following of clinicians who value her outstanding independent, unbiased education and leadership. With a particular interest and highly developed skill-set in diagnostics, Rachel helps Practitioners derive important information from mainstream pathology results. In this episode, Rachel shares insights into common pathology markers, including GGT, ALT and ALP as well as CRP, uric acid and the albumin / globulin ratio. She highlights the importance of monitoring intraindividual shifts and imparts valuable considerations for interpretation. This is a must-listen for health professionals! *Highlights * How does pathology interpretation fit in a Naturopath's scope of practice? (4:30) How are reference ranges determined? (7:50) GGT (12:30) How do you explain atypical results to patients? (15:00) ALT (20:00) CRP (27:00) TSH (31:00) Uric acid (35:30) ALP (39:00) Albumin / Globulin Ratio (42:30) Monitoring intraindividual shifts (50:30) About Rachel Arthur's MasterCourse - Comprehensive Diagnostics (57:30) Useful links and resources: e.g: Follow Metagenics on Instagram - @metagenics_anz (https://www.instagram.com/metagenics_anz/) Website: https://rachelarthur.com.au/ Rachel's Mastercourse Comprehensive Diagnostics: https://rachelarthur.com.au/mastercourse-comprehensive-diagnostics/ Paper Rachel mentions: Whyte MB, Kelly P. The normal range: it is not normal and it is not a range. Postgrad Med J . 2018;94:613–616. Instagram handle: @rachelarthurnutrition

Dr Herman Pontzer is an internationally recognised researcher in human energetics and evolution. He has conducted pathbreaking studies across a range of settings, including fieldwork with Hadza hunter-gatherers in Northern Tanzania, chimpanzee ecology in the rainforests of Uganda, and metabolic measurements of great apes in zoos and sanctuaries around the globe. He recently released the book, Burn: The Misunderstood Science of Metabolism, a fascinating must-read. Nathan sat down with Herman and discussed major theories and research relating to metabolism, including the carbohydrate-insulin model of obesity, the role of the hypothalamus in energy expenditure and lesson learned from the Hadza tribe. *Highlights * The metabolic revolution (3:30) The additive model (14:00) How your brain controls energy expenditure (19:00) We eat what we can get our hands on (30:00) Re-examining the carbohydrate insulin model (36:00) Exercise helps you maintain weight loss (41:00) Studying Hudza life (50:00) Useful links and resources: e.g: Follow Metagenics on Instagram - @metagenics_anz (https://www.instagram.com/metagenics_anz/) Dr Herman Pontzer’s book - https://www.amazon.com.au/Burn-Misunderstood-Metabolism-Herman-Pontzer/dp/0241388422/ref=ascdf0241388422/?tag=googleshopdsk-22&linkCode=df0&hvadid=463870498773&hvpos=&hvnetw=g&hvrand=539011197377358903&hvpone=&hvptwo=&hvqmt=&hvdev=c&hvdvcmdl=&hvlocint=&hvlocphy=9068941&hvtargid=pla-1093754365871&psc=1 The Hadza Fund - https://www.hadzafund.org/ Study by Hall and colleagues “Ultra-Processed Diets Cause Excess Calorie Intake and Weight Gain: An Inpatient Randomized Controlled Trial of Ad Libitum Food Intake” - https://www.cell.com/cell-metabolism/pdf/S1550-4131(19)30248-7.pdf

In this episode, Nathan sits down with Tania de Jong and Dr Alana Roy from Mind Medicine Australia to discuss the use of psychedelics for mental health. Mind Medicine Australia (MMA) is a charity that seeks to alleviate the suffering caused by mental illness in Australia through expanding the treatment options available to medical practitioners and their patients. MMA are focused on the development of safe and effective psychedelic-assisted therapies to cure a range of mental illnesses. *Highlights * Types of psychedelics (6:00) How psychedelics exert beneficial effects (8:30) What the research is telling us (12:00) What a session involves (20:00) A discussion regarding psychedelic safety (25:50) Accessibility of psychedelic medicines (31:00) Mind Medicine Australia initiatives (33:00) Certificate in Psychedelic-Assisted Therapies (CPAT) (36:00) *Useful Links and Resources: eg: * Follow Metagenics on Instagram - @metagenics_anz (https://www.instagram.com/metagenics_anz/) https://mindmedicineaustralia.org.au/ For a Certificate in Psychedelic-Assisted Therapies -https://mindmedicineaustralia.org.au/certificate-in-psychedelic-assisted-therapies-cpat/ Link to the International Summit on Psychedelic Therapies - https://mindmedicineaustralia.org.au/international-summit-on-psychedelic-therapies/ Watch this animation to find out why psychedelic-assisted psychotherapy needs to be available to those who are suffering - https://www.youtube.com/watch?v=VSO8UTQvYUw Link to news in this space - https://mindmedicineaustralia.org/news/ Psychiatrist Dr Paul Fitzgerald’s recent short article on the urgent need for innovation in this space - https://medium.com/@pbfitzgerald/the-challenges-of-depression-treatment-in-2020-abd74269764

What if sugar isn’t as bad as it’s made out to be? Nathan discusses all things sugar with career research scientist and educator Dr Tim Crowe. Dr Crowe draws on 25 years in research to address conflicting information in the field of nutrition. He hosts the popular podcast Thinking Nutrition and is co-author of the book Understanding Nutrition. If you’re looking for a research update on sugar, you came to the right place. *Highlights * Sugar chemistry 101 (6:00) Does fructose cause weight gain? (14:30) Examining sugar addiction (19:00) Myth busting - is there a connection between sugar and hyperactivity? (22:20) Non-nutritional sweeteners: helpful or harmful? (28:00) Artificial sweeteners and the microbiome (34:00) Do we need a sugar tax? (38:00) Useful links and resources: e.g: https://www.thinkingnutrition.com.au/ https://podcasts.apple.com/au/podcast/thinking-nutrition/id1494549885 Links to research mentioned: Declining consumption of added sugars and sugar-sweetened beverages in Australia: a challenge for obesity prevention - https://pubmed.ncbi.nlm.nih.gov/28275129/ Sugar and artificially sweetened beverages and risk of obesity, type 2 diabetes mellitus, hypertension, and all-cause mortality: a dose-response meta-analysis of prospective cohort studies - https://pubmed.ncbi.nlm.nih.gov/32529512/ Effect of fructose instead of glucose or sucrose on cardiometabolic markers: a systematic review and meta-analysis of isoenergetic intervention trials -https://pubmed.ncbi.nlm.nih.gov/33029629/ Which foods may be addictive? The roles of processing, fat content, and glycemic load - https://pubmed.ncbi.nlm.nih.gov/25692302/ Non-nutritive sweeteners for diabetes mellitus - https://pubmed.ncbi.nlm.nih.gov/32449201/

Lara Briden is a naturopathic doctor and bestselling author of the book Period Repair Manual - a practical guide for treating period problems with nutrition, supplements, and bioidentical hormones. This year, Lara has released her new book, The Hormone Repair Manual, which explains how to navigate the change of perimenopause and relieve symptoms with natural treatments. In this episode, she explains the ins and outs of ‘second puberty’ and her favourite nutrients to support this time of life, as well as a fascinating evolutionary perspective on menopause. Tune in for a host of clinical gems! Highlights What motivated Lara to write The Hormone Repair Manual? (1:30) The perimenopausal years, aka ‘second puberty’ (4:00) Novel insights into nutrients for hormonal support (15:00) The recalibration process (19:00) Why you shouldn’t drink alcohol during perimenopause (25:30) Debunking the controversy surrounding phytoestrogens (29:00) The evolutionary take on menopause (33:00) Nutrients for perimenopause and menopause (43:00) Discussion regarding hormonal therapy (50:00) *Useful Links and Resources * https://www.larabriden.com/ https://www.larabriden.com/hormone-repair-manual/ Lara Briden on Instagram - https://www.instagram.com/larabriden/ Metagenics on Instagram - https://www.instagram.com/metagenics_anz/

Kara Fitzgerald and her research team were the first to demonstrate potential reversal of biological age in humans by targeting methylation. In their study, the prescribed program included multiple components with documented mechanistic activity on epigenetic pathways. Tune in to hear the details of her research and learn how to influence your epigenetics. Dr. Kara Fitzgerald has a doctorate of naturopathic medicine, and has been published in numerous peer-reviewed journals. She is on faculty at the Institute for Functional Medicine, and is an Institute for Functional Medicine Certified Practitioner. She regularly lectures internationally for several organizations and is in private practice in Sandy Hook, Connecticut. Highlights What motivated Kara to move into epigenetic research? (2:30) Introduction to epigenetic clocks (9:00) What positively impacts our epigenetics? (24:00) Kara details her research (30:00) Methylation adaptogens (35:00) Kara’s hopes for future research (45:00) *Useful Links and Resources * https://www.drkarafitzgerald.com/ For Kara’s list of methylation adaptogens and links to her books: https://www.drkarafitzgerald.com/professionals/methylation-diet-lifestyle/ Kara’s research - https://www.researchgate.net/publication/342929824ReversalofEpigeneticAgewithDietandLifestyleinaPilotRandomizedClinicalTrial Research links: https://www.drkarafitzgerald.com/professionals/research-news-ideas/ My DNA age - https://www.mydnage.com/ HK Epitherapeutics - http://www.hkgepitherapeutics.com/ About Moshe Szyf - http://www.hkgepitherapeutics.com/about/moshe-szyf/ Metagenics Congress - https://metagenicsinstitute.com.au/congress-2021

As an expert in mast cell activation syndrome (MCAS), Dr Tania Dempsey, imparts priceless information regarding the nature and treatment of this insidious condition. Among many insights, Dr Dempsey explains how to distinguish histamine intolerance from MCAS, the impact of this condition on gastrointestinal health, as well as views on the connection between COVID-19 and MCAS. Importantly, Dr Dempsey draws on years of experience to provide advice on the identification and management of MCAS. Dr. Dempsey is Board Certified in Internal Medicine and a Diplomate of the American Board of Integrative and Holistic Medicine. She has served as an attending physician at a large multi-specialty medical practice in White Plains, NY, and since opened AIM Centre for Personalised Medicine. *Highlights * What is MCAS and how prevalent is it? (6:30) Examining the connection between gut health and MCAS (13:00) Histamine intolerance versus MCAS (21:30) Why a personalised diet is important (27:00) MCAS and COVID-19 (38:20) How to spot MCAS (47:20) Stabilising mast cells and avoiding triggers (53:00) **Useful links and resources: Follow Metagenics on Instagram here - https://www.instagram.com/metagenics_anz/ Or on Facebook - https://www.facebook.com/metagenics Website: https://www.drtaniadempsey.com/ LinkedIn: AIM Centre for Personalised Medicine - https://www.linkedin.com/company/armonk-integrative-medicine#:~:text=Tania%20Tyles%20Dempsey%2C%20MD%2C%20founder,Dr. Twitter account: https://twitter.com/drtaniadempsey?lang=en Paper Tania mentions: Afrin LB, Weinstock LB, Molderings GJ. Covid-19 hyperinflammation and post-Covid-19 illness may be rooted in mast cell activation syndrome. Int J Infect Dis. 2020;100:327-332. doi:10.1016/j.ijid.2020.09.016 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529115/

Science educator, Jason Wilson is the host of The Curious About Cannabis Podcast which answers questions about the world’s most controversial plant – Cannabis. In this episode, Wilson provides an in-depth history lesson on Cannabinoid science, as well as the use of Cannabis extracts for medicinal purposes and the future of Cannabis research. Highlights: Jason’s journey to Cannabinoid research (1:30) A history lesson on Cannabinoid science (14:00) Examining endocannabinoid derangement and supplementation with phytocannabinoids (36:00) The entourage effect (45:00) Lesser known and emerging cannabinoids (55:00) Medicinal cannabis (1:02:00) Directions for future research (1:14:00) Useful links and resources: Follow Metagenics on Instagram here - https://www.instagram.com/metagenics_anz/ Or on Facebook - https://www.facebook.com/metagenics If you are a Healthcare Practitioner in Australia or New Zealand, keep up latest industry news and events by joining our private Practitioner Only Facebook Group - https://www.facebook.com/groups/MetagenicsAU Jason Wilson’s book – Curious About Cannabis: A Scientific Introduction to the World's Most Controversial Plant - https://www.cacpodcast.com/book.html#/

Daniele Piomelli joins us from the University of California, Irvine, where he is the Louise Turner Arnold Chair in Neurosciences and Distinguished Professor of Anatomy and Neurobiology, Pharmacology and Biological Chemistry. Piomelli is the author of over 400 peer-reviewed articles in journals such as Nature, Science, Nature Medicine, PNAS and Nature Neuroscience, three books, and 34 patents. He is also the Director of the Centre for the Study of Cannabis and Editor-in-Chief of Cannabis and Cannabinoid Research, the first peer-reviewed journal entirely dedicated to the study of cannabis, its derivatives, and their endogenous counterparts in the human body. In this episode, he shares a wealth of information regarding the endocannabinoid system and the acylethanolamides, oleoylethanolamide (OEA) and palmitoylethanolamide (PEA). Highlights The endocannabinoid system (3:30) The fascinating history of PEA (25:50) The role of OEA in fat digestion (34:00) Zoning in on PEA (42:00) PEA dosage and time to benefit (56:00) Synergism for pain management (59:00) Useful links and resources: e.g: Follow Metagenics on Instagram here - https://www.instagram.com/metagenics_anz/ Or on Facebook - https://www.facebook.com/metagenics If you are a Healthcare Practitioner in Australia or New Zealand, keep up latest industry news and events by joining our private Practitioner Only Facebook Group - https://www.facebook.com/groups/MetagenicsAU Daniele Piomelli Google Scholar citations - https://scholar.google.com/citations?user=c0v1zcoAAAAJ&hl=en

Dr Tommy Wood earned his medical degree at the University of Oxford, and subsequently completed PhD in physiology and neuroscience at the University of Oslo. Currently, he holds academic positions at the University of Washington and Institute for Human and Machine Cognition. One of Dr Wood’s research interests is developing easily-accessible methods with which to track human health, performance, and longevity. In this episode, Dr Wood shares a plethora of information regarding the science of longevity, including patterns in ageing, determining biological age, and importantly, whether specific ingredients can increase longevity. *Highlights * The fascination with extending the lifespan (5:00) Looking to the Blue Zones (8:30) The biomarkers of ageing (15:50) Determining your biological age (21:00) Biological drivers of ageing (31:40) Diving into caloric restriction (38:00) Macronutrients for health and longevity (55:00) Ingredients to improve longevity (75:00) Useful links and resources: e.g: For more Metagenics follow us on Instagram https://www.instagram.com/metagenics_anz/ If you're a Healthcare Practitioner in Australia or New Zealand, join our private Facebook group https://www.facebook.com/groups/MetagenicsAU Follow Dr Tommy Wood on Instagram here - https://www.instagram.com/drtommywood/ Genetic testing providers Tommy Wood mentions: Elysium - https://www.elysiumhealth.com/en-us/index Chronomics - https://www.chronomics.com/dna Paper – Li J, Bonkowski MS, Moniot S, Zhang D, Hubbard BP, Ling AJ, Rajman LA, Qin B, Lou Z, Gorbunova V, Aravind L, Steegborn C, Sinclair DA. A conserved NAD+ binding pocket that regulates protein-protein interactions during aging. Science. 2017 Mar 24;355(6331):1312-1317. doi: 10.1126/science.aad8242. PMID: 28336669 Link: https://pubmed.ncbi.nlm.nih.gov/28336669/ Paper – Newman S. Supercentenarians and the oldest old are concentrated into regions with no birth certificates and short lifespans. 2019 Jul. doi: 10.1101/704080 Link - https://www.researchgate.net/publication/334497888Supercentenariansandtheoldest-oldareconcentratedintoregionswithnobirthcertificatesandshort_lifespans

In this episode, Nathan had the honour of discussing intestinal permeability and ‘leaky gut’ with renowned gastroenterologist, Dr Eammon Quigley. He is internationally known for his research on gastrointestinal motility disorders, neurogastroenterology and the gut microbiome and has published more than 800 peer-reviewed articles, reviews, editorials, book chapters and case reports. Quigley is past president of the American College of Gastroenterology and the World Gastroenterology Organisation. His current responsibilities include, but are not limited to, the David M. Underwood Chair of Medicine in Digestive Disorders, Head of Gastroenterology and Hepatology at Houston Methodist Hospital, and Professor of Medicine at both the Institute of Academic Medicine and Weill Cornwell Medical College. *Highlights * Debunking the gut barrier (6:00) Evaluating tests to assess gut permeability (12:40) Does targeting paracellular permeability improve disease? (22:00) The role of the gut microbiome (29:20) Maintaining the gut barrier (33:10) Useful links and resources: e.g: Follow Metagenics on Instagram here - https://www.instagram.com/metagenics_anz/ Or on Facebook - https://www.facebook.com/metagenics Keep up withthe latest industry news and events by joining our private Practitioner Only Facebook Group - https://www.facebook.com/groups/MetagenicsAU Article: Quigley EMM, 2016 – ‘Leaky gut - concept or clinical entity?’ - https://pubmed.ncbi.nlm.nih.gov/26760399/ Article: Camilleri M, 2019 – ‘Leaky gut: mechanisms, measurement and clinical implications in humans’ - https://pubmed.ncbi.nlm.nih.gov/31076401/ Article: Zuo L, Kuo WT, Turner JR - Tight Junctions as Targets and Effectors of Mucosal Immune Homeostasis - https://pubmed.ncbi.nlm.nih.gov/32304780/

For anyone fascinated by the gut-brain connection, this episode is sure to pique your interest. Scott C Anderson is a scientist, science journalist and co-author of the book, The Psychobiotic Revolution. With great enthusiasm, he brings us up to speed on gut-brain axis centred research – from the relationship between gut health and depression, to the role psychobiotics and diet in the management of mental health conditions. ** Highlights ** Origins of research on the gut-brain axis (5:20) Chronic inflammation at the root of mood disorders (11:00) Markers used to assess gut health (14:30) The role of the vagus nerve in gut-brain cross-talk (21:20) Does poor gut health cause depression? (23:40) The relationship between gut health and ASD (28:00) Drawing our focus to cognitive health (33:00) What role does the small intestine play in disease? (37:00) Exploring the use of psychobiotics (42:30) Therapies to keep an eye on (57:25) Useful links and resources: e.g: Book –The Psychobiotic Revolution: Mood, Food, and the New Science of the Gut-Brain Connection Amazon link to purchase book - https://www.amazon.com.au/Psychobiotic-Revolution-Scott-C-Anderson/dp/142621846X Website - http://psychobiotic-revolution.com/ Twitter - https://twitter.com/Psychobiotic Psychology today link: https://www.psychologytoday.com/au/blog/mood-microbe

Looking for a novel approach to exercise for chronic disease populations? You’ve come to the right place. Nathan’s guest, Dr Brendan Scott provides a comprehensive review on blood flow restriction (BFR) training, a technique used to enhance muscular strength and hypertrophy through resistance and aerobic exercise. Dr Scott is a Senior lecturer in Strength and Conditioning at Murdoch University and has a keen interest in hypoxic and blood flow restriction training strategies. *Highlights * The origins of BFR training (6:05) What happens when you change blood flow characteristics (11:20) Benefits of BFR training (16:55) Using BFR in aerobic exercise (27:30) Safety concerns for this form of exercise (31:50) The equipment requirements (40:20) The future of BFR research (50:20) *Useful links and resources: * Dr Brendan Scott’s Murdoch University profile, and list of publications - http://profiles.murdoch.edu.au/myprofile/brendan-scott/ Join the Metagenics Practitioner Only Facebook Group here - https://www.facebook.com/groups/MetagenicsAU/permalink/1250761761953759/?comment_id=1251570225206246 Follow Metagenics on Instagram - https://www.instagram.com/metagenics_anz/ or Like us on Facebook - https://www.facebook.com/metagenics

Following his ME/CFS diagnosis 20 years ago, Ashok Gupta went on a journey to reclaim his health. His road to recovery emphasised the importance of retraining his brain and he subsequently created a 7-step program to promote neuroplasticity and support healing from chronic illness. In this episode, Gupta explains the basis for his hypothesis and shares an overview of the steps involved in the brain retraining process. A truly fascinating episode, you shan’t be disappointed! *Highlights * • Looking to the brain (2:55) • Gupta’s hypothesis - “we are survival machines” (4:30) • Why we need to address the cause of complaints (15:00) • Honing in on the amygdala and insular (17:00) • Fear extinction (27:00) • Retraining the brain (30:00) • Research results from amygdala and insular retraining (39:00) • Who would benefit from this program? (44:40) • How to sign up (53:20) Useful links and resources: e.g: https://www.guptaprogram.com/

Whether you’re intrigued by the science of sleep or simply looking for tools to improve your sleep quality, there’s no doubt you’ll appreciate this podcast episode. Nathan’s guest, Greg Potter, has a PhD in sleep patterns, dietary habits and metabolic health, and his research has been featured in the likes of TIME magazine and The Washington Post. Potter expertly answers all-important questions such as how much sleep do we actually need? What do sleep tracking devices offer? And how does CBT-I help in the quest for a good night’s rest? Enjoy the pillow talk with Greg Potter. *Highlights * • The impact of sleep on the immune system (3:10) • Night-time sleep affects day-time mood (8:00) • How much sleep do we actually need? (12:10) • Sleep and ageing (17:40) • Tracking your sleep (19:40) • Why you can’t sleep (30:00) • How to improve your sleep (34:30) • All about CBT-I (37:00) • Sleeping aids and supplements (52:15) Useful links and resources: e.g: CBT-I research links - Systematic Review and Meta-Analysis – 2015 https://pubmed.ncbi.nlm.nih.gov/26054060/?fromterm=insomnia&fromfilter=pubt.meta-analysis&fromfilter=pubt.randomizedcontrolledtrial&fromfilter=pubt.systematicreviews&fromfilter=years.2015-2020&frompos=2 Effect of Digital Cognitive Behavioral Therapy for Insomnia on Health, Psychological Well-being, and Sleep-Related Quality of Life: A Randomized Clinical Trial https://pubmed.ncbi.nlm.nih.gov/30264137/?fromterm=insomnia&fromfilter=pubt.meta-analysis&fromfilter=pubt.randomizedcontrolledtrial&fromfilter=pubt.systematicreviews&fromfilter=years.2018-2020&frompage=3&frompos=6 The Effectiveness of Behavioural and Cognitive Behavioural Therapies for Insomnia on Depressive and Fatigue Symptoms: A Systematic Review and Network Meta-Analysis https://pubmed.ncbi.nlm.nih.gov/28619248/?fromterm=insomnia&fromfilter=pubt.meta-analysis&fromfilter=pubt.systematicreviews&fromfilter=years.2018-2020&frompage=4&frompos=3 Digitally-delivered Cognitive-Behavioural Therapy for Youth Insomnia: A Systematic Review Results showed that eCBT-I improved sleep efficiency, sleep quality, sleep-onset latency and total sleep time with effect sizes ranging from 0.17-1.30 (Cohen's d). https://pubmed.ncbi.nlm.nih.gov/30135762/?fromterm=insomnia&fromfilter=pubt.meta-analysis&fromfilter=pubt.systematicreviews&fromfilter=years.2018-2020&frompage=6&from_pos=7 Some devices mentioned: Ebb device – https://www.ebbsleep.com/ Photobiomodulation device – https://joovv.com/ Oura ring - https://ouraring.com/

From 1994 until 2004 Jane McLelland battled two aggressive cancers with metastatic spread. Using her medical knowledge and researching heavily, she put together a cancer-starving formula, using natural therapies, exercise, diet and a unique cocktail of medications. Her personalised prescription saw her cancer “melt away”. Listen in to hear her remarkable story, and share her wisdom concerning cancer management. *Key Highlights * Jane McLelland’s story (1:55) How Jane created her famous ‘metro-map’ (17:00) Cancer fuel sources (24:00) Can we determine the fuel source for specific cancers? (30:00) Commentary regarding off-label drugs (38:00) Natural constituents (47:00) Drug recommendations (53:00) Ingredients critical to include in the cocktail (60:00) Useful links and resources: e.g: Jane McLelland’s website: https://www.howtostarvecancer.com/ Jane’s McLelland’s book - https://www.howtostarvecancer.com/the-book/

In his words, Dr Brad Dieter’s goal is to use analytics, data science, and a deep understanding of scientific principles to help solve advanced problems. With a background in exercise physiology, molecular biology and biostatistics, Brad proves an excellent guest, as he and Nathan cover the natural history of diabetes and screening tests to assess insulin resistance, to diet debates and the development of obesity – Is it simply a matter of calories in versus calories out? You will have to listen to find out! *Key Highlights * How Brad got started in this field (1:40) A pathophysiology lesson to start (5:10) Looking at the biomarkers (14:15) What drives obesity? Examining the hypotheses (20:00) Looking closer at diets (25:30) Transferring the research into clinic (36:40) Weighing up the ketogenic diet (40:40) Examining personalised nutrition (46:05) Useful links and resources: e.g: https://macrosinc.net/

Whether you are new to Emotional Freedom Technique (EFT), or are a seasoned ‘tapper’, this podcast episode is guaranteed to keep you engaged. Interviewee, Dr Peta Stapleton, is a clinical and health psychologist as well as associate professor in psychology at Bond University. Peta has led world-first randomised clinical trials investigating Emotional Freedom Techniques, adding a wealth of research to this field. *Key Highlights * The origins of EFT (2:30) What does a session involve? (6:10) Is tapping the acupoints essential? (8:35) The effect of EFT on physiology (13:00) Review of the research outcomes (17:30) The astonishing results for cravings and weight loss (27:00) Tapping as a tool for processing emotion (38:00) Navigating addiction with tapping (47:00) The practicalities – training and certification (51:00) Useful links and resources: Follow Metagenics Instagram - @metagenics_anz or Facebook - https://www.facebook.com/metagenics/ If you hold a Metagenics account in Australia or New Zealand join our Facebook Group here - https://www.facebook.com/groups/MetagenicsAU/ Dr Peta Stapleton’s website - https://petastapleton.com/ The Science Behind Tapping - https://petastapleton.com/the-science-behind-tapping/ Guidelines for the Treatment of PTSD Using Clinical EFT (Emotional Freedom Techniques) - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316206/ The Effectiveness of Emotional Freedom Techniques in the Treatment of Posttraumatic Stress Disorder: A Meta-Analysis - https://pubmed.ncbi.nlm.nih.gov/27889444/ Emotional Freedom Techniques for Anxiety: A Systematic Review With Meta-analysis - https://pubmed.ncbi.nlm.nih.gov/26894319/ A Systematic Review and Meta-Analysis of Randomized and Nonrandomized Trials of Clinical Emotional Freedom Techniques (EFT) for the Treatment of Depression - https://pubmed.ncbi.nlm.nih.gov/27843054/

Back by popular demand! Associate Professor Dr Karin Ried joins Nathan to discuss the National Institute of Integrative Medicine’s ISET®-CTC test. Ried explains how the test detects CTCs, including how it can distinguish between malignant CTCs and benign circulating epithelial cells, as well as nuances around interpretation of results and the value of monitoring CTCs. Enjoy the highly informative conversation with Dr Ried. *Highlights * A very good place to start – what is a CTC? (1:30) The role the ISET®-CTC test has in integrative oncology (8:00) Nuances around result interpretation (12:40) Comparing this test to marker tests (21:20) Emphasis on the role of the immune system (29:50) Delivering results to patients (33:20) Delving into cancer screening (39:00) Learnings from examining prostate cancer (40:00) The value of monitoring CTCs (53:30) Therapeutic considerations (105:00) Useful links and resources: e.g: Follow Metagenics Instagram - @metagenics_anz or Facebook - https://www.facebook.com/metagenics/ If you hold a Metagenics account in Australia or New Zealand join our Facebook Group here - https://www.facebook.com/groups/MetagenicsAU/ Paper – ‘New Screening Test Improves Detection of Prostate Cancer Using Circulating Tumor Cells and Prostate-Specific Markers’ - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192049/

Dr Mark Burhenne has been practising dentistry for over 30 years and is the author of the #1 best seller, The 8-Hour Sleep Paradox. His passion for oral health and the importance of healthy sleep shines through in this episode, as he offers important insights about the oral microbiome, P gingivalis and sleep apnoea. *Key Highlights * Burhenne’s short story (1:40) Welcome to the oral microbiome (6:10) Focus on P gingivalis (10:30) Can treating periodontitis improve other disease activity? (15:50) Conventional treatment for periodontitis (18:40) Natural considerations (23:30) All about biofilms and why we should reconsider using essential oils (26:45) Shining light on sleep apnoea (31:20) Why you should seek out a functional dentist (50:30) Useful links and resources: e.g: Follow Metagenics Instagram - @metagenics_anz or Facebook - https://www.facebook.com/metagenics/ If you hold a Metagenics account in Australia or New Zealand join our Facebook Group here - https://www.facebook.com/groups/MetagenicsAU/ Dr Mark Burhenne’s website – https://askthedentist.com The 8-Hour Sleep Paradox: How We Are Sleeping Our Way to Fatigue, Disease and Unhappiness - https://www.amazon.com.au/8-Hour-Sleep-Paradox-Sleeping-Unhappiness-ebook/dp/B015DIQBZ6 The Dental Diet – Dr Steven Lin

Dr. Scott Antoine’s résumé includes 24 years practicing as an Emergency Medicine Physician and six years practicing Functional Medicine. As you can appreciate, he has a wealth of knowledge and practice under his belt, and is well placed to provide an update on Coronavirus pathophysiology and the role of potential therapies in preventing and managing the condition. *Key Highlights * • How Antoine found his way from ER to Functional Medicine (1:45) • The difficulty with examining the prevalence of Coronavirus (7:20) • Pathophysiology update (14:30) • Navigating therapies for Coronavirus (25:20) • The potential of Methylene blue (29:35) • The cytokine storm (35:50) • What can we do to prevent and manage Coronavirus? (41:20) • Special mention to quercetin (49:30) • Stress-related considerations (53:30) *Useful links and resources: * Link to Dr. Scott Antoine’s clinic: www.vinehealthcare.com Link to Antoine’s research – ‘A Literature Review Supporting the Addition of Intravenous Methylene Blue, High-dose Intravenous Vitamin C, Intravenous Glutathione, and Nutraceuticals, to Standard Care for Hospitalized COVID-19 Patients’ https://www.vinehealthcare.com/wp-content/uploads/2020/04/COVID-19-Novel-Therapeutics-A-Comprehensive-Review-of-the-Literature.pdf Link to article - ‘Coronavirus (COVID-19), First Indication of Efficacy of Gene-Eden-VIR/Novirin in SARS-CoV-2 Infections’ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146686/ Link to article – ‘A cohort of cancer patients with no reported cases of SARS-CoV-2 infection: the possible preventive role of Methylene Blue’ https://riviste.fupress.net/index.php/subs/article/view/888 Link to article – ‘Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths’ https://www.mdpi.com/2072-6643/12/4/988 Link to article – ‘A new clinical trial to test high-dose vitamin C in patients with COVID-19’ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7137406/

Coronavirus has brought about a great deal of changes and uncertainty in society. Rose sits down with clinical psychologist, Dr Adrian Lopresti, to discuss the mental and social implications of living with this pandemic. They discuss how to maintain a healthy mindset, including what to do and what not to do, as well as adjusting to new routines in lieu of this significant disruption to our lives. *Key Highlights * • The social and emotional toll of Coronavirus (3:00) • Practical strategies to help manage our exposure to information (8:00) • Incorporating an integrated approach for wellness (9:15) • Advice for our children (15:30) • Using the time to reflect (18:00) • Mindfulness practices (21:20) • Supplement considerations (25:40) • Establishing a new routine (28:30) • Dr Lopresti’s recent research and PI therapy (40:00) *Useful Links & Resources * https://pitherapy.com.au/

This episode provides a synopsis on the Coronavirus with a natural twist. Rose sits down with the perfect guest, Dr Heather Zwickey, who is both knowledgeable and articulate. Dr Zwickey has a PhD in immunology and microbiology, and is currently working as a professor and researcher examining the effects of natural medicines on the immune system. Key Highlights • Dr Zwickey’s origins in immunology (1:35) • Virus = SARS-CoV-2. Disease = COVID-19 (3:10) • Why is this virus more pathogenic than other viruses? (4:10) • What is emerging data telling us about the spread of this virus? (8:15) • COVID-19 in comparison to previous pandemics (9:55) • 48 hours from exposure to symptoms (11:30) • Who is at risk? (13:50) • Conventional treatments available for Coronavirus (22:55) • The potential of natural medicine (29:00) • Is there any risk in supplementing with vitamin D and zinc? (37:10) Useful link: https://heatherzwickey.com/

Research examining photobiomodulation, previously known as low level laser (light) therapy, shows promise for a wide range of ailments, from musculoskeletal complaints to degenerative diseases and psychiatric disorders. This episode covers all the basics and more, including a discussion regarding its mechanism of action and existing research as well as practical advice such as how to choose a light therapy device. Settle in as this podcast serves up a perfect introduction to photobiomouldation. *Key Highlights * • How Scott Nelson arrived in the world of photobiomodulation (3:20) • The foundations (6:30) • How the body harnesses and uses light energy (9:40) • Diving into the applications of light therapy (15:00) • Examining the clinical studies (19:40) • Psychiatric and cognitive health (20:50) • Pain and inflammation (31:00) • Cancer (33:00) • What else does photobiomodulation have to offer? (42:30) • Choosing a device for you and your patients (45:00) Useful links and resources: Light therapy device: Joov - https://joovv.com/ Research: Transcranial Photobiomodulation for the Treatment of Major Depressive Disorder. The ELATED-2 Pilot Trial - https://www.ncbi.nlm.nih.gov/pubmed/30346890 Effects of Low-Level Laser Therapy in Autism Spectrum Disorder - https://www.ncbi.nlm.nih.gov/pubmed/29956199 Systematic review of photobiomodulation for the management of oral mucositis in cancer patients and clinical practice guidelines - https://www.ncbi.nlm.nih.gov/pubmed/31286228

To all research enthusiasts - this is a fascinating podcast episode not to be missed! Associate Professor, Dr Karin Ried, explains NIIM’s Pathogen Blood Test, which involves innovative blood testing using cytology based microscopy, and genetic analysis to isolate and identify pathogens, such as Borrelia bacteria and fungi/mould, in the blood. Prepare to be blown away by the potential of this test! Introduction to the Pathogen Blood Test (4:00) Deep dive into the methods for identifying pathogens (14:00) Identifying stealth organisms (16:30) Insights from live microscopy (19:00) Is EBV at the helm? (21:00) Why supporting the immune system is the priority (24:50) Case Study – Rare fungal infection linked to juvenile arthritis (28:00) Intriguing insights about skin lesions (34:00) Focusing on Lyme like illness (39:30) The practicalities – what the report includes, and how to access it (51:45) Useful links and resources: https://www.niim.com.au/research/academic-staff/aprof-dr-karin-ried https://www.cureus.com/articles/13364-rare-fungal-infection-linked-to-a-case-of-juvenile-arthritis

Dr Nathan Bryan was the first to describe nitrite and nitrate as indispensable nutrients required for optimal cardiovascular health. Rose asks pertinent questions, and Bryan answers beautifully. Enjoy this highly informative conversation and take away a clear understanding of nitric oxide production and the importance of this molecule for health. What is nitric oxide and how do we make it? (3:00) Looking at the difference between nitrates and nitrites (10:15) The significance of the oral microbiome in the production of this molecule (17:30) The challenge with recommending nitrate enriched foods (24:00) The importance of nitric oxide for the body (28:00) Clinical symptoms that indicate nitric oxide deficiency (34:30) Fascinating results obtained from supplementation (37:00) What’s on the horizon for this field of research (42:40) Dr Nathan Byran - https://drnathansbryan.com/

In this episode, Nathan is joined by Dr Robert Hendren, a Professor of Psychiatry and Behavioural Science at the University of California, San Francisco and author of well over 100 scientific papers and five books. From the get-go, it is clear Hendren is deeply committed to his work, and as such, provides valuable insight into the complex pathology that is autism. Hendren speaks of his first clinical trial, which launched him on his current career path (2:00) Elucidating the etiology of ASD (6:00) Factors influencing gene expression (8:00) Looking to the mitochondria (11:00) The infamous gut-brain axis - what role does it play in ASD? (17:30) Environmental toxicity – do we treat it and if so, how? (26:00) Sulforaphane holds promise (31:20) Spotlight on metabolomics (34:00) Functional testing (38:50) Professor Hendren’s hopes for the treatment of ASD (43:50)

Professor Tommy Wood explains the effects of specific single nucleotide polymorphisms (SNPs) on an individual’s health outcomes. From his analysis of what has been presented in the literature and widely accepted in functional medicine circles, Tommy discusses the relevance of SNP testing and highlights the difference between “relative risk” and “personal risk” whilst expanding on additional factors that should take precedence when treating a patient. • Professor Tommy Wood discusses his journey into genetic testing and SNPs (06:00) • Single nucleotide polymorphisms (SNPs), gene testing and phenotypes (11:21) • Fat mass and obesity-associated SNP and obesity risk (14:15) • FOX03 SNP and lifestyle interventions (18:44) • SNPs associated with risk of obesity (20:00) • Melatonin receptor 1B SNP effect on elevated fasting blood sugar (23:17) • Pre-diabetic risk, SNPs and environmental factors (25:11) • Catechol-O-methyltransferase SNPs, dopamine and cognitive function (32:39) • Methylenetetrahydrofolate reductase SNPs, homocysteine and folate (38:13) • The personalized diet and SNPs (45:27) • The placebo/nocebo effect of genes (50:15) • Utilising testing outside of genetic testing in clinical practice (56:58)

Chris Masterjohn, PhD currently spends time on nutrition education, conducting independent research and consulting. He has deep and personal experiences with the power of food, movement, and mindfulness to support health and well-being. • How choline was recognised as an essential nutrient. (6.35) • Why choline reduces fatty liver. (11.52) • Dietary sources of choline and its relationship with betaine. (16.31) • Why the RDI for choline may not be enough. (20.53) • The relationship between methylation and choline. (24.49) • How to assess someone’s choline, B12 and folate status. (26.57) • The importance of choline in pregnancy and infancy. (36.09) • Teasing out the TMAO controversy. (41.17) • Optimising folate status: Interpreting testing and intake. (51.10) • Beyond folate forms: Addressing MTHFR SNPs with creatine, vitamin B2, choline and glycine. (53.45)

In this thought-provoking and highly informative interview, Nathan is joined by Ari Whitten – energy and fatigue specialist, and founder of The Energy Blueprint. Whitten gets real about the factors contributing to fatigue; dispelling common myths and reminding us about the importance of the universal basics to support energy production. When life intervenes, how Whitten found himself pursuing a career as an energy and fatigue specialist. (1:37) Does adrenal fatigue exist? (5:50) The relationship, or lack thereof, between cortisol levels and fatigue. (12:00) Why we should look to the mitochondria to understand fatigue (16:27) Is it worth testing for mitochondrial dysfunction? (28:18) Deliberating the value of screening for fatigue. (38:58) Assess and address circadian rhythm function (48:48) The importance of universal basics (53:25) The dance between antioxidants and pro-oxidants (1:02:00) Useful Links and Resources https://www.theenergyblueprint.com/

Amina Eastham-Hillier is a Naturopath, Medical Herbalist and Nutritionist who specialises in solving the unique patient puzzles presented with Lyme disease, mould illness, parasites, viruses and other stealth infections. As acclaimed author of Lyme Natural and international presenter and educator to medical practitioners, she combines naturopathy and science to clear a path to healing for even the most complex of cases. Where to start in a complex case (6:52) The real prevalence of stealth infections, and why some people get so ill (8:50) The discover and detection of pathogens; testing and beyond (11:53) Beyond killing pathogens in the path to healing (20:20) Supporting energy is fatiguing illness (28:28) Tailoring treatments for pathogens, acute and chronic presentations (30:30)

Take a trip down the vagal nerve with Nathan Rose and his guest Dr. Adrian Lopresti as they wander the landscape of strategies to stimulate this infamous pathway. Dr. Lopresti is a Clinical Psychologist in private practice, and senior researcher at Murdoch University with a host of published articles under his belt. Vagal nerve 101 (2:00) The relationship between heart rate variability (HRV) and vagal nerve activity (4:13) Dive into strategies to stimulate the vagal nerve (9:47) Take a breath for the vagal nerve (13:15) Why exercise is a useful tool (16:52) A spotlight on nutrients & diet (20:00) Is bioavailability of curcumin the be-all and end-all? (25:13) The current landscape on mood enhancing probiotics (29:16) Lopresti shares his thoughts on supporting HRV and vagal tone in clinical practice (36:09) Delve into Lopresti’s world – an update on research in action (38:40)

In this episode, Dr Erik Lundquist from the Temecula Centre for Integrative Medicine, shares the results and learnings of a recent trial using specialised pro-resolving mediators (SPMs) to address fibromyalgia symptoms. As Lundquist relays the details of the study, he offers a genuine account of his experience, bringing to light the complexities and realities of treating individuals living with fibromyalgia. While SPMs may not be a panacea, in his opinion, they are ‘an exciting new tool that we’re just scratching the surface on.’

Professor Serhan expands on the application of SPMs inside the inflammation-resolution cycle and outside this cycle, highlighting alternative mechanisms, the wide scope of SPM therapy and exciting new treatment considerations currently within the field of lipid research. Prof Serhan background on moving into studying lipid mediators. (1:30) Aspirin triggers biosynthesis of lipid mediators. (4:57) Old to new: Review of inflammation and stimulating resolution processes. (6:55) Resolvins reduce neutrophilic infiltration and inducing “self-limitation”. (11:14) Plasticity of macrophage poles – key function of SPMs. (13:48) Healthy human breast milk contains SPMs. (19:45) Structures, receptors and functional location of Resolvins. (20:44) Downregulation of biosynthetic enzymes and using SPMs. (25:00) Aged mice with enhanced inflammatory response and diminished resolution response. (29:00) SPMs in obesity models. (31:00) Role of SPMs in additional chronic inflammatory conditions. (40:05) SPM killing and clearance of infections without immune suppression. (44:34) SPMs, macrophage types and tumor reduction. (46:45) Topical SPM application in animal models. (49:51) Future publication on periodontal disease. (52:53)

Dr Bill Harris has nearly four decades of experience as a lipid researcher and joins the podcast to discuss the benefits of the omega-3-index test. Listen to Dr Harris explain how the omega-3 index has demonstrated to be the best measure to date of omega 3 status and how this metric may be a more valuable marker of cardiovascular health than traditional biomarkers. Learn the nuances behind the mixed results of clinical trials of EPA/DHA for cardiovascular health, reinforcing the clinical efficacy of EPA/DHA supplementation. Hear Dr Harris’s surprising research findings on omega 6 status which makes you rethink the stereotype of omega 6 fatty acids.

Today Dr Ruscio clears a path to understanding the role of thyroid in any patient’s presentation. As usual, his approach is levelled at the most important testing whilst assessing patient’s diet and lifestyle for conservative treatments to save his patients time, money and their health. Challenging both standard and functional medicine approaches, he shares his evidence-based algorithm for thyroid management.

Dr Kara Fitzgerald joins Nathan Rose to discuss the epigenome, the effect of methylation on gene expression and looking at interventions outside the use of supplemental methyl donors to modify our epigenome for a healthy life.

Prof. David. O. Carpenter, MD, PhD (USA), Director of the Institute for Health and the Environment, is an internationally renowned expert in the human health effects of environmental contaminants, including non-ionizing radiation. He talks to Nathan Rose about his research and experience in dealing with sufferers of electromagnetic hypersensitivity (EHS) and other environmental intolerances.

Greg Potter PhD is a researcher and content director at HumanOS.me, an online platform helping people lead healthier lives. Greg’s thought-provoking research explores the associations between sleep duration, diet, physical activity and metabolic health. This podcast highlights the vital role sleep plays in health and the social influences that impact our sleep-wake cycle.

Northern Californian Doctor, author and medical consultant, Dr. Neil Nathan specialises in patients with serious, resistant chronic illness. In this podcast he discusses the clinical implications emerging from the Cell Danger Response, a revolutionary model developed by Dr. Robert Naviaux that explains how the body essentially gets “stuck” fighting a threat even after the danger has passed.

Dr Scott Kahan is the Director of the National Center for Weight and Wellness. A researcher, author, lecturer and experienced physician, he specialises in treating obesity. Dr Kahan balances the latest scientific approaches to treating obesity, with his passion for implementing behavioural changes.

Dr Tania Dempsey is an expert in chronic disease, autoimmune disorders, mast cell activation syndrome (MCAS), and the role these conditions play in hormonal disorders. Dr Dempsey is sought after internationally for her knowledge of chronic immune dysregulation, and uses Integrative Medicine to get to the root cause of disease.

Australian medical researcher, educator and author shares intriguing clinical insights from her research. She brings the neurobiology of appetite control to life, and explains how ‘diet breaks’ work to help people lose weight and keep it off. She also reviews the latest research on intermittent fasting and time restricted feeding to bring you up to date in obesity research.

Researcher, Neuroscientist and Author Stephan J. Guyenet has spent 12 years studying the neurobiology of body weight regulation. His book, The Hungry Brain, explores why many of our patients overeat, and provides practical, evidence-based strategies to overcome the hungry brain.

Lara Briden is a renowned Naturopathic Physician with over two decades of clinical experience spanning across Canada, Australia and New Zealand. Lara’s experience with thousands of female patients has been the inspiration behind her book, The Period Repair Manual which educates and empowers women to seek better solutions when it comes to their reproductive health. In this episode, Nathan and Lara cover the latest science surrounding endometriosis and discuss Lara’s approach to reversing the pain and delaying disease progression.

In this episode, Nathan talks to leading expert in the fields of environmental medicine and building biology, Nicole Bijlsma. Nicole is a Building Biologist, Author, Naturopath, PHD candidate and founder of the Australian College of Environmental Studies. She joins Nathan to discuss the sometimes controversial subject of electromagnetic field exposure. What are the greatest sources of EMFs? How do they affect our physiology? And how can we help to minimise EMF exposure and build resilience?

Chris Kresser M.S., L.Ac is a globally recognised figure in Functional Medicine, and has been studying, practicing, and teaching natural health for over 15 years. In this episode, Chris discusses the unique, personalised framework of Functional Medicine, and how a functional approach to clinical care can address the limitations of the conventional healthcare model. Further, Chris discusses the evidence for urinary pyrroles, the recent outcomes of the DIETFITS study and his clinician training program, ADAPT.

In this episode, Nathan Rose delves into the complex world of Mast Cell Activation Syndrome (MCAS) with Board Certified General Practice Physician Dr Sandeep Gupta. Dr Gupta draws on his clinical experience with chronic inflammatory illnesses and offers listeners a digestible take on MCAS. Throughout the interview, Rose elicits valuable tips for clinical practice; including how to recognise an MCAS patient, testing options and considerations, as well as therapeutic solutions, both natural and pharmaceutical.

Lihi Segal is the CEO and co-founder of revolutionary microbiome-based health app, DayTwo, which uses big data and machine learning algorithms to create personalised nutrition plans. DayTwo is based on research conducted by Professor Eran Segal and Eran Elinav from the Weizmann Institute in Israel, which was used to create an algorithm that can predict a patient’s glucose response to foods based on their personal and microbiome data. The algorithm was shown to accurately predict blood glucose responses in 800 participants whose individual blood glucose was highly variable in response to the same meal. Since 2016, DayTwo has offered their accessible and personalised healthcare services throughout Israel and the United States, delivering evidence-based and personalised healthcare to consumers.