Podcasts about tmao

Today, I am delighted to reconnect with Dr. William Davis. He's a cardiologist, New York Times bestselling author of the Wheat Belly book series, and author of Super Gut. He is also the founder and Medical Director of the Infinite Health Program and the co-founder and Chief Medical Officer of Realize Therapeutics Corp, which is developing innovative solutions to restore and support the human microbiome. In our conversation, we explore the microbiome and how it is influenced by key changes in a woman's life, including pregnancy and premature delivery, as well as how modern lifestyle factors disrupt our microbiome. Dr. Davis discusses endotoxemia and dysbiosis in fertility, uterine health, and cardiovascular disease, as well as antibiotic use, statins, atrial fibrillation, the role of blood glycocalyx, TMAO, and the dietary approach he considers important. He also discusses appropriate prescribed antibiotic use in the context of microbiome disruption. Stay tuned for another fascinating discussion with Dr William Davis on the far-reaching impact of the microbiome on women's health, heart health, and longevity. I look forward to having Dr. Davis back on the show! IN THIS EPISODE, YOU WILL LEARN: How factors such as omega-3 fatty acid intake and microbiome health may affect pregnancy outcomes. How microbial health extends beyond the gastrointestinal tract and can influence multiple organ systems The disruptive effects of antibiotics, glyphosate, food preservatives, and emulsifiers on the microbiome Dr. Davis describes how endotoxemia can affect the brain, skin, joints, metabolism, and cardiovascular system. How endotoxemia influences multiple cardiovascular risk markers How endotoxemia and glycation can contribute to atrial fibrillation The role of the glycocalyx, and how damage to the integrity of the glycocalyx could influence arterial function and cardiovascular risk Why fermented foods remain a key strategy for microbiome diversity Dr. Davis shares his dietary choices and his approach to microbiome support  Bio: William Davis, MD  William Davis, MD, is a cardiologist and #1 New York Times bestselling author of the Wheat Belly series of books, as well as Undoctored and Super Gut. Recent human clinical trials that Dr. Davis conducted have revealed that it is possible to lose fat weight while preserving muscle, thereby preventing weight regain and enjoying improved body composition, findings that inspired the writing of Bulge. Dr. Davis is also Chief Medical Officer at Realize Therapeutics Corp., which he co-founded to explore the new science of the microbiome to improve health and appearance, including body composition. Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website. Submit your questions to support@cynthiathurlow.com  Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow.  Purchase Cynthia's book, The Menopause Gut. Cynthia's Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Connect with Dr. William Davis On his website Join Dr Davis's Inner Circle Dr. Davis's books

Dr. Deb Muth 00:08What if the toxins in your food and water weren’t just harming our bodies, but rewriting the very code of human health? My guest today, MIT scientist Dr. Stephanie Sineff, has spent over a decade connecting the dots between environmental toxins, metabolic chaos, and neurological decline. You’ll want to hear every word of this conversation. You guys can put our, Serenity ad in here, and then I’ll do the standard intro.Welcome back to Let’s Talk Wellness Now, the show where we uncover the root causes of chronic illness, explore cutting-edge regenerative medicine, and empower you with the tools to heal. I’m Dr. Deb, your medical detective.And today, we’re diving into how environmental toxins and nutritional imbalances are silently shaping chronic disease patterns, from autoimmune disorders to neurodegenerative decline. And how we can take back control of our health. So, as usual, grab your cup of coffee, tea, or whatever helps you unwind, settle in, and let’s get started on your journey to deeper healing. So, Dr. Sunif, so glad to have you here. I can’t wait to have this conversation with you. We were just chatting off-camera a few seconds ago about what we’re going to chat about, but tell us a little bit about your background and how you got into this field of looking at toxins and mitochondria. Seneff 01:50Okay, yeah, my background is a bit eclectic, so it starts out with biology. I have an undergraduate degree in biology from MIT. My PhD is in electrical engineering and computer science, so that’s quite a switchover. And most of my career, I was writing computer code to train computers to talk to humans in a natural conversation… conversational interaction with computers. We were pioneers in that space. You can see that it has really taken off now. And actually, by 2006, 2007, I started to realize that the kind of work I did already then was getting compromised by the, by the emergence of AI. And I got concerned that, I wouldn’t be able to sustain the path I was on. And it’s happening now, of course, to the young… many people, young people today, are facing a crisis in computer science, because it used to be if you had skills in hacking code, you were good to go, you know, and that’s just not true anymore, so that’s another whole story, but anyway, I decided I needed to do something different, and I pivoted in a big way in 2007. managed to get the company that had been funding me, a Taiwanese company called Quanta Computers, And they,We’re willing to switch over to funding me to do research on health and toxic chemical exposures. Which was a miracle that they let… they let me switch over to that, and that was fantastic, 2007. So it’s been almost 20 years. that I’ve been looking for toxic chemical exposures and their association with human disease. And I focused initially on autism and heart disease, kind of for personal reasons, because I knew people who had, you know, who had those issues.But it led into a much, much bigger story, and I’m super excited about what’s happened over the last 20 years. It’s been a continual learning experience for me, and I’ve just kept broadening my space in biology, furiously reading papers as I discovered new concepts and trying to explore those. opening up new windows, and it’s just been a profusion of learning over the past 20 years, and I’ve published many papers at this point. Peer-reviewed papers on the topics of toxic chemical exposures and disease. Particularly, glyphosate is the one I really focused on, and I wrote the book, Toxic Legacy, how the weed killer glyphosate is Destroying Our Health and the Environment.That was published in 2021. So. Dr. Deb Muth 04:18So I’m sure you have a few thoughts about the administration wanting to bring that back to be made at home instead of China, right? Seneff 04:26I know, that’s so interesting. And actually, you know, he makes a point that I agree with, which is that we are relying on China. for importing a whole bunch of stuff that’s really toxic, and we’re pouring it all over our food supply, so China’s probably very happy to poison us, you know? Oh, absolutely. It’s kind of ironic that we’re doing that, and he makes a good point that we shouldn’t be relying on China for these chemicals that are poisoning us, but where he misses the point is he says, well, we just need to poison ourselves, you know? Rather than getting rid of that chemical, we need to really change the way we grow food.I think it’s the number one most important thing right now. in America is to change the way we grow food, and it has to be certified organic, regenerative. We need to focus on healing the soil, just as we have to heal the gut. I mean, we’ve really messed up the microbes in both the soil and the gut, and the consequences, as you can see, are a huge problem with human disease. Dr. Deb Muth 05:20They’re devastating. I mean, we have so much chronic illness and so much neurological disease these days, and just the rise of autism, it should be telling us that we’re doing something wrong, right? Seneff 05:31Absolutely. Dr. Deb Muth 05:32We have a problem. For those people who are listening that don’t understand what the term glyphosate is, can you explain that a little bit to them? Seneff 05:39Yeah, so it’s one of the many herbicides that we use. We use herbicides, fungicides, and insecticides in agriculture, all these poisons, and it kind of seems crazy to me that we would think it’s okay to pour poisons all over our food supply. I don’t understand why we think that’s fine.Yeah. You know, categorically. Glyphosate is supposed to be a wonderful chemical, because it’s an herbicide that kills all plants except for those that have been engineered to resist it. And supposedly is completely harmless to humans. And that’s what gets to be, you know, disbelief, because how can something so toxic to plants be harmless to humans? Just, how can it be? Dr. Deb Muth 06:14We haven’t been re-engineered like the seeds that they use from Monsanto, so how can it not affect us if it only affects everything but their seeds that they’ve modified to make grow beautifully under that condition? It doesn’t make any sense. Seneff 06:32Right, and of course, the critical thing they missed is that our gut microbes do have that pathway. It’s the chicken mate pathway that it disrupts. Really critical in all the plants, and in most of the microbes. In the soil and in the gut, and so it kills off the microbes as well as the plants, and when it kills off your gut microbes, you gotta watch out, because gut dysbiosis is a huge thing. And we’ve had so many papers coming out lately that Talking about the relationship between gut dysbiosis and all kinds of different diseases. Dr. Deb Muth 07:01Do you think that’s why we see so much gut dysbiosis these days? Seneff 07:04Oh, absolutely. I think it’s not just glyphosate, because we have lots of poisons that are messing up our gut microbes, but glyphosate is a really big one, because the shikimate pathway is essential for many of the microbes, and they use it to make essential nutrients for the host. So we get compromised as well, just because they can’t make those nutrients in that. Dr. Deb Muth 07:22It’s so… Seneff 07:22lies. Dr. Deb Muth 07:23so much harder today to treat people with gut issues than it was 25 years ago when I started. It was so much easier. And now, it’s, like, nearly impossible sometimes to get some of these people back to a good, healthy gut microbiome, no matter what you do, no matter how well they eat, and all the things that they do. It’s a struggle, for sure, compared to what it was 20 years ago. Seneff 07:44It’s interesting that you have that personal experience, because I think people like you really can see what’s happening. Dr. Deb Muth 07:49and appreciate. Seneff 07:50the difference between then and now. I, of course, as a child, autism was not something I knew about at all. Really, when I was a child. It didn’t exist, basically. I mean, it was so rare. And now, you know, everyone knows someone with autism, you know, pretty much. Dr. Deb Muth 08:08Autism and Parkinson’s and Alzheimer’s seems to be just so much commonplace. Everybody knows somebody in their family that is affected by one of those disorders, if not multiples, and We tend to say it’s genetic, right? Well, there’s got to be a genetic… why wasn’t it genetic 50 years ago, or 100 years ago? But now, all of a sudden, it’s so prevalent in our environment that we’ve just become acceptable of it, and I think that’s wrong for us to do that. We shouldn’t be doing that. Seneff 08:38I know. I find it very interesting how quickly it appears that humans adapt to the new normal, you know? Dr. Deb Muth 08:44Yeah. Seneff 08:45It’s normal that you have, you know. 3% of the kids have autism, that’s normal, you know? It’s just like, no, it’s not. And also, of course, all the Alzheimer’s and dementia and Parkinson’s, as you mentioned, in the elderly, those are connected, because they’re all related to brain problems that are being caused by chemicals that are destroying the brain. Dr. Deb Muth 09:03Yeah. So, how does glyphosphate interact with our body’s ability to absorb those essential nutrients, like sulfur? Seneff 09:12Yeah, well, it’s… that’s a big… that’s a big question. I don’t know where to begin with that one. Glyphosate, you know, it’s a train wreck for the gut microbes, and then that causes the gut dysbiosis. The microbes are unable to produce adequate amounts of nutrients that are essential for the host. And as a consequence, the host cells get sick, you know, so the colonocytes get sick because they’re not getting adequate nutrition. Because the microbes can’t produce the nutrition they normally would produce. I think that’s a good summary of what’s going on. You get inflammation in the gut.And then the inflammation causes immune reactions, so you get the immune cells coming in, and they create inflammation, you know, it’s just like there’s a kind of a festering going on in there that’s really a train wreck for the whole system. Dr. Deb Muth 09:58Do we see different, results with things like this in Europe, where they’re not allowed to use a lot of these chemicals that we’re allowed to use here? Seneff 10:07Yeah, they are allowed, but it’s much, much less there. My friend, Tony Mitra got his government, Canada, to do a test… to do a big test of over 8,000 samples, food samples, to get… look for glyphosate. U.S. government doesn’t bother to test for glyphosate, because they consider it to be safe.We know it’s all over our food supply from work by people like Zen Honeycutt. My friend Zan Honeycutt of Moms Across America has really been on a mission to test all kinds of different food samples for glyphosate and finding it extensive in our food supply, in the school lunches. in the fast food restaurants and the food that’s fed to the Army. She’s done all these different studies, breast milk. Wines, you know, all the wines were contaminated, even the biodynamic, which are organic.Had small amounts of glyphosate, so it’s just like it’s all over the food supply. Canada did 8,000 samples. Tony Beecher finally got them to do that after many years of harassing them, and then he published the results in a book called Poison Foods of North America, because they found that they had imports from Europe, imports from Mexico, imports from the U.S, And basically, the U.S. and Canada came out way on top, as far as overall, the numbers were much higher in those two countries. And Mexico lined up with Europe, which was quite interesting to me. So, you know, you’re better off if you buy food from Mexico. Dr. Deb Muth 11:31Yeah, and I wouldn’t have thought that, I would have thought that was different. Seneff 11:34And I know you often think that Mexican food is not going to be as carefully regulated, and you might get some kind of, toxin. You don’t expect Mexican food to be healthier than American, but it is. Dr. Deb Muth 11:44Yeah. Yeah, can you talk a little bit about deuterium? What is deuterium? Seneff 11:51Okay, that’s a good place to start. Yeah, deuterium… I am absolutely fascinated with deuterium, and I believe that the team of researchers that I’m working with, we are on to something really huge. I’m super, super excited. I almost can’t contain my excitement with this, because once we started looking, it’s just like everything made so much sense. Everything kind of came together. In terms of metabolism, and disruptive metabolism, and all the stuff that’s going on in the gut. It really, really makes sense. Deuterium is heavy hydrogen. It’s a natural element. Hydrogen is the smallest element, the upper left corner of the periodic table. One proton and one electron, and it’s by far the most common atom in the universe.And in our body, as well, by far the most common atom in our body, and it’s involved in all the chemical reactions that take place. And so, you know, have carbohydrates. The hydrates is hydrogen, you know, in the word carbon, hydrogen, carbohydrates. And of course, carbohydrates are, you know, basic foods. So anyway, deuterium has an extra neutron. It’s just like carbon-14, so carbon-12, carbon-14 is a little bit heavier. It’s got 14 instead of 12. It has extra neutrons. So there are these kind of isotopes of various atoms, but hydrogen has hydrogen, deuterium, and tritium. Tritium has two extra neutrons. It’s very rare, and deuterium has one extra neutron, and it’s rare compared to hydrogen, but it’s not rare, because hydrogen’s so common. So it’s actually present in the blood at five times the level of calcium, for example. Dr. Deb Muth 13:24Oh. Seneff 13:25So it’s not rare, but it’s a very interesting atom that has caused us trouble in the mitochondria. Dr. Deb Muth 13:32Is it actually considered a toxin? Seneff 13:34It’s a natural element, you know. I mean, you have natural elements that are toxic, you know, like some of those metals, like mercury, for example, is a natural element, but it’s toxic, so it’s not a chemical, it’s not a chemical, you know, not made in the chemical lab. It’s just an atom. And it’s all over the universe. It’s not like you can avoid it, or you can, you know, you can’t get rid of it. It’s everywhere. And so it’s a natural part of biology, and our biology has evolved. to very, very clever ways to protect the mitochondria from deuterium. So the thing is, mitochondria have ATPase, which makes ATP, and ATP is the universal… it’s the energy source for the cell.ATP. It’s made in the mitochondria, very, very important, oxidative phosphorylation, you know, that’s sort of basic in biology. And, those ATPase pumps, depend upon hydrogen flowing through the pumps to generate, motor force to make the ATP.And they pile up the hydrogen inside an inner membrane space. They’re kind of cute. The mitochondria have this internal matrix in the hole, like a donut hole. The matrix is where a lot of activity is going on. And then there’s a membrane, but the membrane has both an outer membrane and an inner membrane. So there’s an intermembrane space where the mitochondria dump a lot of protons. They make… put lots and lots of protons in there, and then the protons naturally come out through basic… through basic physics, they come out, and the pumps are there to grab the energy as the protons come out. It’s quite cool. Go back into the matrix. the protons go back into the matrix. So what the body does is it tries to keep deuterons out of those… out of that intermembrane space. It tries really hard not to put deuterons in there. So deuterons are the equivalent of protons.You know, proteom is the normal hydrogen, and then deuterium is the… is the one with the extra neutron that makes it twice as heavy. So because it’s twice as heavy, it behaves very, very differently. It’s kind of like a big, bulky thing coming through the pumps, and it can clobber them. It can really mess them up.And the body knows that, and so the body has designed incredibly elegant mechanisms to keep the deuterium levels inside that inner membrane space as low as possible. the body obsesses on that. And once you realize that, all of a sudden, lots and lots of things make sense in terms of looking at biochemistry and what’s going on. All kinds of things that didn’t make sense before suddenly come. clear… clear… are motivated by this idea of avoiding deuterium in the inner membrane space. So it’s really, really fascinating biology. Dr. Deb Muth 16:08So does the glyphosate tend to increase the deuterium in that space, or does it disrupt it? Seneff 16:16It definitely increases it, and the reason why is because it disrupts the enzymes that manage it. And so, for example. So this, I have to get into hydrogen gas and microbial production of hydrogen gas, which is central to the story. And you know, people get gashy, they have, like, bloating and stuff, there’s a lot. Dr. Deb Muth 16:34echo. Seneff 16:34That’s because those gases that are being made by the microbes are unable to be brought back into organic matter. So normally the microbes make lots and lots of gas, and they start with hydrogen gas, and they make methane gas, they make hydrogen sulfide gas, and they make all these gases. And then they use those gases as reducing agents to come back and make organic matter. So they basically convert food into basic gases, like hydrogen and carbon dioxide, right? And then they take the carbon dioxide and hydrogen to convert it back into food. And the reason why they do that is because the process of making the gas tremendously strips out the deuterium. This is absolutely central, I think, to metabolism.And it’s not something very many people are aware of. The microbes make the hydrogen gas. And when they do that, they lose 80% of the deuterium, because the deuterium tends to stay in the aqueous space, because it’s too heavy. You just think of, you know, trying to lift out… if you’re twice as heavy, it’s a lot harder to get out of the liquid into the air. You know, so basically to make the gas. When you make the gas, you lose a lot of the deuterium. And that is super, super central, I think, to metabolism. Dr. Deb Muth 17:47So, if that’s what’s happening inside of there, it’s obviously creating metabolism issues. What does that mean for energy and mitochondrial health, then? Seneff 17:58Well, what happens is that the microbes are unable to make enough of those nutrients that are super for the host that have low deuterium. And a particular one that I have in mind is butyrate. And I don’t know if you know anything about butyrate. Dr. Deb Muth 18:10Yeah. Seneff 18:12But it’s a very healthy resource for the gut. The colonocytes lining the gut, 80% of their food is butyrate. They love butyrate, normally. But lots of people have butyrate deficiency in their gut. And that deficiency is due to the fact that the microbes can’t make the hydrogen gas, because when they make the hydro… or they can’t bring the hydrogen gas back in to make. Dr. Deb Muth 18:34Beautiful. Seneff 18:35Because a butyrate comes from the hydrogen gas that’s produced by the gut microbes. Dr. Deb Muth 18:39So, if we supplement with N-butyrate, does that help that process work better, or does it not really do much with the deuterium, then? Seneff 18:48Well, there’s a big question with supplements, and I’m really starting to appreciate this more. You know, I always like natural, right? Natural versus synthetic. And I think there’s a huge difference. For many of these supplements that are popular, there’s a huge difference between natural and synthetic. Yeah. And that big difference has to do with the level of deuterium, because if it’s made synthetically. It’s not going to be depleted in deuterium. So when you’re taking… and I don’t know butyrate, you have to go and look at how they manufacture it to see if it comes from natural or synthetic ingredients. It’s extremely interesting with… I’ve looked into some of these other nutrients that people like to take as supplements. Choline by tartrate is one that I really was fascinated with, because… and there are papers that show that if you take choline by tartrate as a supplement… so choline, of course, is a very important nutrient, a lot ofAre deficient, especially if they’re vegetarian. And choline bitartrate is a synthetic form of choline. And, choline bitartrate, if you take… the studies have shown There’s a beautiful study that had people who ate a bunch of eggs, you know, because eggs are high in choline, and then they had people who took choline by tartrate to get an equivalent amount of choline in their diet compared to the eggs, right? And the people who ate the eggs were fine, and the people who ate the choline bitartrate were not. They had a very big increase in a metabolite called trimethylamine oxide, TMAO. Dr. Deb Muth 20:13in the. Seneff 20:14in the blood. And TMAO is a risk factor for a huge number of diseases, you know, all the usual suspects, the diabetes, the cholesterol, the heart disease, cancer, all kinds of diseases. Dr. Deb Muth 20:26TMA over. Seneff 20:26is a very interesting molecule that’s been studied quite a bit recently. There’s a lot of papers on it. I don’t know if you’ve heard of it, TMAO . Dr. Deb Muth 20:32I have, yeah. Seneff 20:33Yeah, okay. Well, that one is a… it’s very, very interesting, and I have a paper that I’m trying to get published right now that I’m quite proud of that talks about all of this, but they found that when you eat the eggs and get the choline that way, you’re fine, but if you take the choline bichartrate, you’re not. You get all this TMAO. And the reason, I think, is because the microbes… the microbes make TMA from choline. the trimethylamine. Choline has a nitrogen atom with 3 methyls attached to it, and those methyls are going to be really low in deuterium. Because they’re part of the methylation pathway, which microbes make sure those methyls are low in deuterium. So all the whole methylation pathways, I think, is a distribution system to deliver low deuterium nutrients throughout the body, not just in the gut. You know, and the body has all these ways of hooking methyls onto things. Dr. Deb Muth 21:26and take it. Seneff 21:26them off, and when it takes them off, it metabolizes them in the mitochondria, delivering to them low deuterium nutrient. So, so when you take the choline bitartrate, and it’s not low deuterium, what happens is you end up with molecules of TMA, trimethylamine, that have deuterium in them. And when you have those, they won’t… the microbes won’t metabolize them, they won’t turn them back into hydrogen. You know, deuterium depleted hydrogen, they won’t do it. So they stick around, the TMA doesn’t get metabolized, and then it gets sent to the liver, the liver turns it into TMAO, and now you’ve got your problem. And I think TMAO is a marker for deuterium overload in the mitochondria, in the methylation pathways. Dr. Deb Muth 22:06That’s interesting that you’re talking about that. I belong to a group, and we’ve been researching plosmalogen therapy, and one of the supplements that was created was created with a large amount of phospholine. And,And by itself, when we used the phospholine in one of our formulations, it wasn’t bad, but when they doubled the dose and they were putting it in all of their formulations, people were starting to see the TMO levels go up. And we were trying to figure out, like, what’s happening here. It wasn’t everybody, but it was a good chunk of people, enough for us to say, hey, something needs to change here. We need to take out this phospholine, or not use as much of it. But now this explains exactly why the TAMO was going up. And if those people do have a lot of deuterium, maybe why we saw some people have a problem with it, but not everybody had a problem with it. Seneff 22:57It depends on their microbes. If their microbes are healthy enough to be able to metabolize the TMA, they’re fine. And the microbes produce the TMA, and then they metabolize it. And they’re doing that to generate more deuterium-depleted nutrients. They’re constantly trying to come up with new nutrients that are deuterium-depleted to feed to the host. I mean, they’re really obsessed with it. And they do a good job, normally, but they get so messed up by all these chemicals, and not just glyphosate, of course, all the chemicals in our food and in the air, it’s a mess, you know? Dr. Deb Muth 23:26It’s amazing the body works as well as it does. Seneff 23:28It is. I really am surprised that we don’t have more people who are super sick, you know? Dr. Deb Muth 23:33Exactly. Seneff 23:33Not for sure, but some of us are doing okay with it, you know? Dr. Deb Muth 23:37Yeah, exactly. So when we have this high level of deuterium, high levels of glyphosphate, what is that going to do to the body’s energy stores? Seneff 23:46well, it’s going to wreck the mitochondria, and then you’re going to get chronic fatigue. I mean, I think chronic fatigue syndrome, to me, is a very clear example of mitochondrial damage due to excess deuterium. I think that can completely explain that disease. Dr. Deb Muth 24:01Do you think this high level of deuterium is causing people to see more neurological diseases as well, like Alzheimer’s and Parkinson’s? It’s fueling it. Seneff 24:11Absolutely, because the brain has so much dependence on energy, you know, the brain uses a lot of energy, and they need really healthy mitochondria. They have… neurons have lots of mitochondria. Neurons and muscle cells really, you know, are loaded up with mitochondria, and both of them get injured when they don’t have a… when they can’t keep deuterium out of the mitochondria. Dr. Deb Muth 24:30The cells. Seneff 24:31get injured by all the reactive oxygen the mitochondria are producing, which the ATPase pumps, once they’re getting contaminated with all that deuterium, they start spewing out reactive oxygen. It kills the mitochondria, then it kills the cell, then it kills the brain, you know? It’s like a progression. It really starts with the mitochondrial damage, and then the cell dies, and once the neurons start dying, then the brain dies, you know, and you’ve got all. symptoms. Dr. Deb Muth 24:55So can we measure deuterium like we can glyphosphate in the body? Seneff 24:59You can, yes. In fact, you can do a saliva test and send it off and get the… get a level of how much deuterium is in your saliva. I would love to know more… in more detail how much deuterium is in different parts of the body, because that’s really interesting to me from my studies. What I’m suspecting is that the body… so the cells actually dump deuterium outside the cell. That to try to get as little deuterium as possible inside the cell. And within the cell, they’re trying to get as little deuterium as possible inside the mitochondria. So there’s layers of trying to get rid of the deuterium. And so the convenient thing is to dump the deuterium outside the cell. So there’s a lot of deuterium in bones, for example, probably in your skin, you know, any kind of exterior materials. And the sort of glycocalyx, so there’s this glycocalyx that lines all the blood vessels.That’s these sort of complicated sulfated sugar… complex sugar molecules that, that create gelled water. this gets into Gerald Pollack’s work. I don’t know if you know anything about Gerald Pollack and gelled water, but that’s quite a fascinating field all by itself. But it has to do with really fascinating stuff, because Gerald Pollack talks about battery… a battery being created by the gel. He’s done a lot of research on gelled water. You know, like jello, for example.And you put some powder, you put some hot boiling water, you let it sit, it gels up. It’s mostly water, but it’s a funny phase of water. It’s called the… he calls it the fourth phase of water. He wrote a whole book about that. Gerald Pollack did. And, it’s a gel phase, so water has, you know, the liquid, the solid, the gas, and then the gel. And… and most of the water in our body is gel, is gelled. And especially all the water lining the blood vessels. The blood vessels have free-flowing blood in the middle, right? Dr. Deb Muth 26:46in the long… Seneff 26:46the edges, they have this gelled water that’s created by these sulfated glycos… I mean, the glycans, they’re called, complicated word there, but… They create the gelled water, and the gel… actually, what Pollock showed is that the gel becomes negatively charged, and it pushes out protons. It pushes protons out into the blood. And it ends up being negatively charged because of that. And it creates a battery, and that battery is a source of energy, so… so you can think of, the gel as being like a battery supporting the entire body. All the gel in the blood is a battery. It’s a giant battery. And when you get exposed to sunlight, the gel grows in volume by a lot, and so when the gel gets bigger, it gets to be a bigger battery, and it’s capturing the energy in sunlight. It’s like a solar panel. your skin is like a solar panel, capturing the energy in the sunlight and converting it into this energy in that gel that pushes out those protons. And the cool thing is the deuterons tend to stay behind Because, It’s a little bit of interesting physics here when you have a water molecule, could have one deuterium, one hydrogen, and an oxygen. Water is H2O, right? It would be HDO, one hydrogen, one deuterium, and oxygen, right? HGO. And when you separate that out, usually you separate water out into OH- and H+, right, when you pull it apart into ions. OH minus and H+. Well, what happens here is that the deuterium sticks harder to the oxygen. than the hydrogen does. So you get OD- and H+. more often than OH minus and D+. Dr. Deb Muth 28:22So you have a lot fewer D pluses inside that gel. Seneff 28:26And the H pluses go out into the blood, and the D pluses are… the Ds are stuck to the oxygen, so they don’t go out. So you end up, actually, that’s a sort of distillation process that pulls healthy proteins out of the gel, into the blood. And that makes the blood levels of deuterium lower. Do you see what I’m saying? The deuterium gets trapped in the gel. And the deuterium gets trapped in bone in the same way, in the bone, in the skin. So the body’s trying to keep the deuterium out of the cell, and within the cell, it’s trying to keep it out of the mitochondria, and actually out of all the organelles, not just the mitochondria. So it’s… there’s a whole… Metabolism cannot be explained without looking at deuterium. Dr. Deb Muth 29:07Yeah, so if deuterium’s getting trapped in the bone, much like lead does, does it take up space where we can’t have calcium, and then it leads to more osteoporosis as well? Seneff 29:16I don’t think so. I think deuterium is actually healthy in the bones. Dr. Deb Muth 29:19Interesting. It actually makes the bone stronger, and in fact, there was a really beautiful article on seals. Seneff 29:24You know, SEALs, they do the deep dives, they get into this really, high-pressure zone. Dr. Deb Muth 29:28with… Seneff 29:29in deep water. So they have to be really strong, and the seals actually dope up their bones with twice as much deuterium as what is normal. So they concentrate deuterium. They showed it with the seals, they concentrate deuterium in their bones, and the deuterium makes the bones stronger, so they can sustain the high pressure of the dot. Do you hear the thunder? We’ve got a big thunderstorm. Dr. Deb Muth 29:52So, when you’re testing for deuterium in saliva, are you testing the excess, then? Like, what the body doesn’t. Seneff 30:00Well, there’s the. Dr. Deb Muth 30:00The waste of it? Seneff 30:01It’s really complicated, because I think it’s hard to know how to interpret it. It’s just like when you test for, like, you know, toxic metals, like mercury, like in the hair, you can do a. Dr. Deb Muth 30:13It’s in the hair. Seneff 30:14And sometimes you can find someone who actually has a problem with that metal, but the hair doesn’t show it. Dr. Deb Muth 30:20Bismar. Seneff 30:21doesn’t actually excrete it in the hair, so you have to think about Can the body get rid of it that way? And actually, in the saliva, I believe the saliva the body concentrates deuterium in the saliva, because it’s trying to get rid of deuterium. So a way to… you have the salivary glands, and they can actually excrete, preferentially excrete deuterium. Into the saliva. to concentrate it there in order to keep it out of the body. But those enzymes that do that might be compromised, in which case you have less deuterium in your mouth, but that doesn’t necessarily mean that’s good. You see what I mean? So when you see whatever the level is, it’s hard to interpret it, I believe. Dr. Deb Muth 30:58Yeah, it’s hard to tell what to do with it, then. Seneff 31:01Yeah, whether it’s low because your salivary glands aren’t working well, or whether it’s low because your whole body’s low, you know? And you can’t really know which way that goes, necessarily. So that makes it hard to interpret, I think. Dr. Deb Muth 31:13It sure does. Seneff 31:15I’m interested, for example, breast milk has low deuterium. Saliva has high deuterium. And you’re… I haven’t been able to find… there’s very few measurements, so I’d like to see a lot more measurements on the… just what’s typical, you know? Right. Dr. Deb Muth 31:31expect the urine to have hydrocherium, so anything that you’re excreting, I would expect it to have hydrocherium. So, knowing this information that we have, how does one fix these metabolic issues that we’ve kind of created in our own environment, for lack of a better term, because of our own… our own misgivings of what we’ve done in the world. How do we protect our brain and repair that metabolic issue in the mitochondria these days, then? Seneff 31:58I would say the most essential thing is to eat certified organic food. Dr. Deb Muth 32:02Always buy certified organic. It doesn’t guarantee that it’s free from chemicals, but it’s generally better. Seneff 32:07So that’s… we’ve been practicing that ever since 2012, when I figured out that glyphosate is causing a mess. So we went organic, and we’ve been like that ever since. We did a purge, we threw away everything, even the spices, started over in our kitchen. Yeah. In 2012, and then we’ve just been consistently buying certified organic ever since then. Dr. Deb Muth 32:27at least lowers the load, right? I mean… Seneff 32:29Yeah, it’s. Dr. Deb Muth 32:30There could be… Seneff 32:30some contamination. Dr. Deb Muth 32:31there, but… Seneff 32:32It’s a lot less, generally, but not zero, not necessarily zero. Dr. Deb Muth 32:35Right. Seneff 32:36undetectable. But that’s a really important thing. Another thing is to eat… I think eating fiber can help the microbes to produce those low-deuterium nutrients. The microbesWe can’t digest… our cells don’t know what to do with fiber, but the microbes can digest the fiber, turn it into hydrogen gas, turn it back into nutrients, like short-chain fatty acids, you know, butyrate. So, by eating foods that contain fiber, you’re helping the microbes to produce butyrate, and butyrate is really, really important for the health of the colon, you know? Dr. Deb Muth 33:07Yeah, and we’re talking about eating whole food organic, not organic Doritos and Cheetos. Seneff 33:13Right, right. Dr. Deb Muth 33:14kinds of things, right? Seneff 33:15Whole foods is really important. I always say whole foods and organic foods, those are the two really important things. And then I don’t really, you know, there’s all these different fad diets with respect to, a loss of fat, or no fat, and all that kind of thing. I don’t buy into any of those. I think you just want to have a balanced diet.Carbs are okay, you know, fats are really healthy, and especially animal-based fats are healthy. I don’t like a vegan diet, because I think animal-based foods provide certain nutrients that are really hard to get otherwise. And like I say, you can’t take choline by tartrate to replace the choline that’s in the animal-based foods. Dr. Deb Muth 33:48Right. Yeah, I’ve worked a lot, and I’ve never seen a healthy vegan. I mean, we can say we’re vegan.But those people are eating a lot of junk food, typically. They’re not true vegans, where they’re just eating whole food and getting all their nutrients from good quality foods. Most of the people that I’ve worked with over the years that have been vegan eat a lot of processed foods, a lot of junk foods. It just doesn’t include the animal fats, and then that makes them unhealthy, and we see a lot of nutrient deficiencies and a lot of pain and energy issues. It’s very hard to be a healthy vegan. In my opinion, as well. Seneff 34:20I agree, I agree, yeah. Dr. Deb Muth 34:23So I like to ask this question of all of my guests, and if you were designing a public health policy tomorrow, what would your first change be? Seneff 34:32To switch the farming system to be small farms that are regenerative, not just organic, organic regenerative small farms, with no use of chemicals. Dr. Deb Muth 34:42Yeah. Seneff 34:43No insecticides, no fungicides, no herbicides, nothing, you know? And even natural fertilizer, of course, as well. Of course, right now, you know, the organic farms rely on the chickens to get. Dr. Deb Muth 34:57the. Seneff 34:58Manure, which has glyphosate in it, so they… they get their glyphosate from the manure. Dr. Deb Muth 35:04Yeah, because a lot of that chicken feed has glyphosate in it, and then they’re passing that through, and we think that it doesn’t pass through, but it does pass through, and… Yeah, I would agree with you. I think when we went to these big industrial farming practices, we did not do ourselves any favor. And shipping food across the country to be slaughtered, only to ship it back here. Seneff 35:29It doesn’t make any sense, and… Dr. Deb Muth 35:32Growing things in environments where people live that isn’t natural to them, that doesn’t make sense to me either, in a lot of ways. Seneff 35:41Yeah, it’s very frustrating, because I think we really… it’s too bad that we lost all those small family farms, because we need them back. We really need them back, and I think that’s really the… and you want to have a variety of different crops, you know, we have all these massive cornfields, that’s just wrong. Dr. Deb Muth 35:55Yeah. Yeah, and they do nothing but corn until…Until your county says you have to do something different now, because you’ve depleted the soil too much, and they don’t want to put any soil preservation back in, and put any nutrients back in, because that’s expensive. Seneff 36:12Exactly. Dr. Deb Muth 36:13And then they’ll rotate the crop maybe once a year, and then they’re back to growing corn again, because that’s the largest revenue producer for them at the time, and it really is a challenge for us. Really a challenge. Seneff 36:26Yeah, it’s going to be very difficult to pivot to the kind of agriculture we need, and if we don’t do it, we’re just going to get sicker and sicker. Dr. Deb Muth 36:33Like, my friend. Seneff 36:34frightening. Dr. Deb Muth 36:35Yeah. Seneff 36:35How sick we are. Dr. Deb Muth 36:37Yeah, and I think people trying to grow their own food, at least some of it, can be really helpful and beneficial, too. We need to go back to that practice. Seneff 36:44I know, yes, rooftop farms, right? Dr. Deb Muth 36:47Back in the city. Seneff 36:48That’s really quite cool. I’ve heard some lectures on that. Dr. Deb Muth 36:51Yeah. Yeah, even some of the hydroponic growing that you can do in your apartment and get some lettuce and some herbs and things like that. I mean, anything that you can grow yourself, I think, is a big benefit. A, you don’t. Seneff 37:03I think it’s. Dr. Deb Muth 37:04B, you know how it’s been grown. C, it’s just healthier for you, and it’s less that you’re gonna have to buy that you don’t know that, what’s been growing in it, so… Seneff 37:13And it’s also kind of fun, right? You feel good that you’ve produced your own food. I think it’s really quite neat. Dr. Deb Muth 37:18Yeah, and there’s something, therapeutic about digging in the dirt a little bit, and getting your hands dirty. Seneff 37:24It’s really good to be outdoors and getting exercise. I mean, really, the work that’s involved with growing food is quite healthy work, really. Dr. Deb Muth 37:31Yeah, it’s a lot of work, for sure. That it is. So, for listeners that might be feeling a little overwhelmed about what we’re talking about, and thinking about, how do I detox or nutrition, where do I get some of this education, what kind of resources would you recommend for them? Seneff 37:47That’s a tough one. There’s not much known about deuterium, so it’s really quite difficult to… you can search deuterium, and there are some… a couple of good resources, which I can’t name, I could probably send you a link, describing deuterium. I know there’s a woman who’s written some nice material. on deuterium, just to get a sense of… more… a better sense of what it is, and why it’s a problem. But there’s not much. I mean, we need to have a lot more. I really want to get the research community aware that. Dr. Deb Muth 38:17They need to be. Seneff 38:17researching deuterium and its role in the body, because I think it’s absolutely essential. We’ll never understand disease if we don’t look at deuterium. Dr. Deb Muth 38:24Yeah, I think so, too. I think… I think the… there’s a lot of amazing discoveries that are being found. That could open the doors and give us answers to reversing a lot of disease, if there was funding behind it, if there were people like you that were interested in it, to really dig down from a functional medicine standpoint and try to figure it out instead of looking at it from a big pharma aspect, where we just need to find a pill that’ll fix it. Seneff 38:50I know. Dr. Deb Muth 38:51There are not pills that are going to fix these kinds of things. Seneff 38:54Right, yes, pharma’s way off base, I think. They’re really going after the completely wrong approach to health. Dr. Deb Muth 39:01I agree. Well, thank you so much for joining me today. It’s been a pleasure. Is there any last words that you want to leave with our listeners? Seneff 39:09I don’t know, I just, you know, healthy living is basically just eating whole foods, eating organic foods, getting plenty of fiber and fermented foods.And healthy fats, you know, sort of a variety of diet, a really mixed diet. Lots of fresh vegetables. I mean, there’s all these different great things to eat. Just stay away from the soy protein bars, you know, and the candy bars, and that sort of thing. And the cookies, I mean, just, you know. And then, of course, getting outside in the sunlight is something I always have to say. I love the sun. I think it’s very therapeutic, and we don’t get enough sunlight. We’re just. Dr. Deb Muth 39:43We don’t. And if we do, then we’re lathering on all of our sunscreen so that we don’t get the sun, and that’s creating its own issues, right? Seneff 39:51That’s right. Dr. Deb Muth 39:54Well, thank you so much for being with me today. Seneff 39:56Thank you. My pleasure. Dr. Deb Muth 40:03Thank you for joining me today on Let’s Talk Wellness Now. If this episode has resonated with you, share it with another woman ready to reclaim their health and their vitality. And remember, wellness isn’t just about feeling good, it’s about thriving in every area of your life. If you’re ready to explore personalized regenerative medicine. Please visit serenityhealthcarecenter.com. You can also follow me on social media, and join our free programSeen at Last community on Facebook. Until next time, I’m Dr. Deb, reminding you to care for your body, mind, and spirit. Be well, and I’ll see you on the next episode. Meta Boxes Use up and down arrow keys to resize the meta box pane.Toggle panel: AIOSEO Settings SERP Preview Let’s Talk Wellness Now https://letstalkwellnessnow.com › 2026 › 06 › 05 › episode-267-env…The post Episode 267 – Environmental Toxins, Nutrition, and Their Role in Chronic Disease Development first appeared on Let's Talk Wellness Now.

How CD38, PARP, and Leaky Gut Are Destroying Your NAD Levels | Dr. Andrew Salzman Your NAD is being drained by two hidden enzymes, your gut may be the starting point of every aging process in your body, and creatine does something to your mitochondria that has nothing to do with muscle. This episode rewrites what you thought you knew about longevity, anti-aging biology, and how your body actually produces and delivers energy at the cellular level. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR -Explore all of Wonderfeel's products at: getwonderfeel.com/dave They are gifting a complimentary 7-day Youngr™ supply (mini pouch) with every order across any of their products. The code will be DAVE, and the campaign will be active through June 6th. Host Dave Asprey sits down with Dr. Andrew Salzman, a physician, inventor, and biomedical entrepreneur with more than 30 years of experience in drug discovery and development. An alumnus of Harvard Medical School, Yale University, and Columbia University, Dr. Salzman has authored more than 170 scientific publications and holds 50 patents. He invented the original clinical-stage PARP-1 inhibitor, leading to the world's first clinical treatment for raising NAD levels and fighting cancers caused by the BRCA1 and BRCA2 genes. Genentech licensed his breakthrough technology for $600 million. His research into gastrointestinal microbiota, autoimmune disease, oxidative stress, and mitochondrial ATP production now forms the foundation of how millions of patients get treated worldwide. Dr. Salzman names the two biggest NAD drains in your body, CD38 and PARP, and explains why taking NMN or NR alone is like filling a bathtub with the drain wide open. He breaks down the formulation science behind pairing NAD precursors with CD38 blockers like hydroxytyrosol alongside PARP-reducing antioxidants like ergothioneine, and delivers a paradigm-shifting explanation of creatine as an energy distribution network inside your cells. Rather than a simple muscle supplement, creatine acts as a high-speed ATP shuttle that carries energy from your mitochondria to the precise location and moment your brain, gut, and heart need it most. You'll Learn: Why NAD declines with age and which two enzymes are primarily responsible for draining it How CD38 rises with inflammation rather than NAD levels, and what that means for your supplement strategy Why creatine is one of the most underrated anti-aging and brain optimization supplements available How creatine functions as a spatial and temporal energy delivery network for your brain, gut, and heart Why the gut may be the origin point of the entire aging process and how that cascade unfolds decade by decade How leaky gut drives systemic inflammation, crashes NAD, and accelerates biological aging throughout the body What controls tight junction integrity and how ATP, butyrate, creatine, and fasting all play a role Why most creatine supplements fail to absorb properly and what to look for in a high-quality source How to rebuild your microbiome in three to four weeks through diet alone, without antibiotics Why walking immediately after a meal may be doing more harm than good to your gut lining Thank you to our sponsors! - Screenfit | Get your at-home eye training program for 40% off using code DAVE at https://www.screenfit.com/dave. - KILLSwitch | If you're ready for the best sleep of your life, order now at https://www.switchsupplements.com/and use code DAVE for 20% off - Pique | Go to Piquelife.com/dave for 20% off. - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Dr. Andrew Salzman, NAD depletion, CD38 inhibition, PARP inhibition, NMN supplements, creatine ATP shuttle, leaky gut aging, tight junction integrity, inflammaging, lipopolysaccharide gut, flagellin toxin, butyrate gut healing, ergothioneine, hydroxytyrosol, peroxynitrite, superoxide mitochondria, creatine energy distribution, gut origin of aging, NAD bathtub analogy, BRCA PARP inhibitor, Wonderfeel, creatine monohydrate, intestinal permeability, microbiome butyrate, selective digestive decontamination, TMAO nitric oxide Resources: • Explore all of Wonderfeel's products at: getwonderfeel.com/dave • Order Youngr™: getwonderfeel.com/dave• Order ChocoCreatin™: getwonderfeel.com/dave• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 01:12 – Introduction & BRCA Background 02:19 – DNA Damage & PARP 04:38 – Free Radicals & Oxidative Stress 11:37 – NAD & Antioxidant Defense 12:34 – CD38 & NAD Depletion 23:31 – The Gut-Aging Hypothesis 30:05 – ATP, Creatine & Energy Distribution 36:41 – Creatine as Energy Shuttle 51:09 – Microbiome & Gut Repair 59:21 – TMAO & Nitric Oxide Interference 1:03:52 – Flagellin & Gut Inflammation Research 1:09:45 – FDA & Pharmaceutical Incentives 1:16:05 – Closing See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Even half an egg a day increases mortality. Replacing red meat with soy, nuts, or plants slashes risk of death and disease. #CholesterolTruth #EggRisk #HealthyProtein

A case study where a second opinion is necessaryWhat are your thoughts on the recent news implicating niacin in cardiovascular disease? 

What if “processed” isn't the enemy, and the biggest health gains come from something far simpler, eating more real plants most of the time? We take a clear-eyed look at the processing spectrum, from chopping and freezing to fortification and engineered ultra-processed products, and map out where processing genuinely helps and where it quietly pushes us toward overeating.We start by grounding the conversation in evidence: Canadians pull 60% of calories from ultra-processed foods while only 5 to 10% come from whole or minimally processed plants. We unpack the NOVA categories and explain how physical processing like cooking and freezing can preserve or even improve nutrient accessibility, why fortified foods such as iodized salt and calcium- plus vitamin D–enriched milks fill real nutritional gaps, and how pasteurization and shelf-stability reduce waste and improve safety. Then we draw the line between helpful processing and the formulations that add sugar, sodium, and refined fats while stripping fiber, exactly the combo that fuels cravings and calorie overload.From there, we get practical. You'll hear how frozen berries and canned beans can be everyday allies, why protein powders, plant or whey, can legitimately boost satiety and lean mass when your base diet falls short, and how legume and whole wheat pasta elevate fiber and protein without sacrificing convenience. We tackle context too: white pasta has a smart place before endurance efforts, while higher-fiber options serve best for weight management and metabolic health. We also touch on meat alternatives and why swapping red meat for plant-based burgers can lower TMAO and nudge cardiometabolic markers in the right direction.The takeaway is simple and doable: push more of your plate toward whole plants, use minimally processed shortcuts that protect nutrients and budget, and reserve ultra-processed options for targeted needs, not default meals. If this reframed the way you see your pantry, tap follow, share it with a friend who loves nutrition debates, and leave a review to tell us your biggest “aha.”Go check out my website for tons of free resources on how to transition towards a healthier diet and lifestyle.You can download my free plant-based recipes eBook and a ton of other free resources by visiting  the Digital Downloads tab of my website at https://www.plantbaseddrjules.com/shopDon't forget to check out my blog at https://www.plantbaseddrjules.com/blog You can also watch my educational videos on YouTube at https://www.youtube.com/channel/UCMpkQRXb7G-StAotV0dmahQCheck out my upcoming live events and free eCourse, where you'll learn more about how to create delicious plant-based recipes: https://www.plantbaseddrjules.com/Go follow me on social media by visiting my Facebook page and Instagram accountshttps://www.facebook.com/plantbaseddrjuleshttps://www.instagram.com/plantbased_dr_jules/Last but not least, the best way to show your support and to help me spread my message is to subscribe to my podcast and to leave a 5 star review on Apple and Spotify!Thanks so much!Peace, love, plants!Dr. Jules 

This week, Dr. Kahn discusses his long-standing interest in the amino acid glycine and its potential health benefits. Sleep is a key focus, highlighted by a new report on the widespread difficulty adults face in getting a full night's rest. Glycine may also offer favorable cardiovascular support. Additional topics include coffee and aging, methamphetamines and heart attacks, Lipoprotein(a) and cardiovascular risk, yoga and overall health, a tribute to Eugene Braunwald, MD, TMAO and atherosclerosis, and a new study on the benefits of adopting heart-healthy habits early in life.  Thanks to the Fresh Pressed Olive Oil Club and the special discount offer at getfreshdrkahn.com

"This is a special series I'm running called The Correction. It lives separately from TMAO but I wanted to bring it here first. Here's Episode 04."

"This is a special series I'm running called The Correction. It lives separately from TMAO but I wanted to bring it here first. Here's Episode 03."Episode 03 — The Correction with G MoneyMs Rose showed love by doing things. I watched that. I learned it. I became it.My grandmother didn't talk about love in the abstract. She showed it — food on the table, shoes on your feet, a roof that didn't move. Ms Rose's love was a verb, not a noun. And she was the most powerful person I have ever known.So I became her. The utility. The constant showing up. The need to be useful to earn my place.But somewhere in this episode I ask a question I can't stop sitting with — is there a difference between showing love through doing, and only feeling worthy when you're doing something?Same behaviour. Very different root.That's Entry 03 of The Correction.The Correction is a podcast about unlearning the habit of leading with utility — and learning to just be present instead. New episodes every Monday and Thursday.

Animal foods and oils damage your gut and arteries, trigger TMAO, and fuel inflammation. Plants don't. #NoOilDiet #TMAO #ArteryHealth #HealthTalks

"This is a special series I'm running called The Correction. It lives separately from TMAO but I wanted to bring it here first. Here's Episode 02."Someone asked me a simple question. I couldn't answer it. Not because I didn't want to — but because I realised that everything I do is also work. This is Episode 02 of The Correction. The Correction drops every Monday and Thursday. Full series at conradgray.com

"This is a special series I'm running called The Correction. It lives separately from TMAO but I wanted to bring it here first. Here's Episode 01."The one that started everything.A few weeks ago I sat in a therapy session and two words came up — hyper competent. My therapist said it like a diagnosis. My first instinct was to take it as a compliment. And then she finished the sentence.This is Episode 01 of The Correction. I read the first entry in the series and talk around it — what was happening when I wrote it, what I didn't write, and where this thread is going.No guests. No agenda. Just honest.The Correction drops every Monday and Thursday.Read the full series at conradgray.com

RNA microbiome testing reveals what DNA gut tests fundamentally miss. Your gut bacteria have 3,000+ genes each — DNA tests see zero of their actual activity. Dr. Momchilo (Momo) Vuyisich, Co-founder & CSO of Viome and former Los Alamos National Laboratory scientist, explains why RNA-based metatranscriptomics is a quantum leap over DNA sequencing for understanding your microbiome and personalizing nutrition. Meet our guest Dr. Momo Vuyisich spent 12 years at Los Alamos National Laboratory developing RNA-based technology for digitizing human biology. He co-founded Viome in 2016 with Naveen Jain, and the platform has since tested 500,000+ customers across 100+ countries. His personal journey with NEU5GC autoimmune sensitivity drove his mission to replace opinion-based nutrition with data-driven, personalized recommendations. Thank you to our partners Outliyr Biohacker's Peak Performance Shop: get exclusive discounts on cutting-edge health, wellness, & performance gear Ultimate Health Optimization Deals: a database of of all the current best biohacking deals on technology, supplements, systems and more Latest Summits, Conferences, Masterclasses, and Health Optimization Events: join me at the top events around the world FREE Outliyr Nootropics Mini-Course: gain mental clarity, energy, motivation, and focus Key takeaways DNA microbiome tests show composition only — RNA tests reveal which of 3,000+ bacterial genes are actually active 16S rRNA sequencing cannot distinguish pathogenic bacteria from beneficial ones Akkermansia can protect or destroy your gut lining depending on fiber intake and gene expression Carnitine supplements may cause cardiovascular disease via the TMAO pathway in certain people Viome's biological aging clock shows keto and paleo dieters age faster on average No whole food is universally good or bad — personalization requires your own molecular data The gut microbiome stays stable for 5-6 months; test semi-annually Viome currently measures 25,000 of ~100,000 biochemical reactions powering the body Three randomized controlled trials validate Viome's personalized nutrition approach   Episode highlights 00:00 Introduction 02:44 Why RNA is the single best molecule to study 06:16 RNA instability — why it took 6 years to develop 08:02 Why 16S sequencing is nearly useless 11:02 Akkermansia's 3,000 genes: help or harm? 17:37 Microbiome as a dynamic self-adjusting ecosystem 23:20 NEU5GC sensitivity & mammalian food reactions 25:50 Food sensitivities (IgG) vs allergies (IgE) 29:55 Viome's 3-part approach: seal gut, reduce inflammation, personalize 41:07 Biological aging clock: keto & paleo age faster 49:13 Dry fasting crashed mitochondrial function score 52:07 Machine learning identifies metabolic bottlenecks 1:00:23 Viome measures 25% of human biology, 10% actionable   Links Watch it on YouTube: https://youtu.be/bB8Zj_9pIv8  Full episode show notes: https://outliyr.com/257  Connect with Nick on social media Instagram Twitter (X) YouTube LinkedIn Easy ways to support Subscribe Leave an Apple Podcast review Suggest a guest Do you have questions, thoughts, or feedback for us? Let me know in the show notes above and one of us will get back to you! Be an Outliyr, Nick

This week, Dr. Kahn breaks down new research on dementia risk, including the roles of high blood pressure and early menopause. He looks at conflicting studies on red meat and ApoE4, which pretty much sums up nutrition science: one study says yes, another says absolutely not. For now, limiting red meat—especially processed—is still the safest move. He also covers the risks of skipping breakfast, calcium CT scoring for elevated lipoprotein(a), tooth loss and heart disease, long-term clopidogrel use after stents, ultraprocessed foods, Repatha and statins, Cleerly AI scans, micro-exercise breaks, and why elevated TMAO may increase blood clot risk.  This episode is sponsored by Igennus. Visit igennus.com and use code DRKAHN for a discount.

The replay of the 4th Reversing Heart Disease Summit is going on now. Register here: drtalks.com/summits/reversing-heart-disease This week, Dr. Kahn addresses the newly published 2026 guidelines for the management of hyperlipidemia (high cholesterol), which will be studied and used by medical professionals all over the world. The top 10 takeaways are presented and are similar to the approach used at the Kahn Center for over a decade. Other topics include the challenge of staying vegan, the influence of cold temperatures on aortic dissection, the development of clogged arteries after a normal heart artery CT scan, the role of olive oil on the brain, red light therapy and music and the autonomic nervous system, plant-based diets and TMAO, bacteria and the brain, the role of a low uric acid level, the advantages of Eliquis over Xarelto in a new trial, and the FDA inquiry into the maker of Wegovy and Ozempic.  Thanks to Igennus.com for their support. Use the discount code DrKahn to save.

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HEALTH NEWS A Simple Diet Change Could Slow Liver Cancer Brief, intensive exercise helps patients with panic disorder more than standard care Lucid dreaming could be used for mental health therapy, new study says US cancer institute studying ivermectin's ‘ability to kill cancer cells Too many saturated fats may be more harmful than too many refined carbohydrates.    Clips   Andrew Bridgen - https://x.com/ABridgen/status/2020573528571977993?s=20 MAHA Alliance Mike Tyson Super Bowl Commercial - https://www.youtube.com/watch?v=jg1SjFt1a_U   KETO DIET RISKS    The rationale for Keto Diet by its advocates Restricting carbohydrates, suppressing insulin and ketosis will lead to better metabolic heath, increase weight loss, reduce inflammation, and protect from chronic diseases.   Keto Claim: Carbohydrates raise insulin leading to fat storage – keto lowers insulin and burns body fat better Debunking: Ketosis is a metabolic state and not a health outcome. For example ketones can be elevated by very long fasting, starvation, different illnesses and uncontrolled diabetes.   Keto Claim: By minimizing carbs keto stabilizes blood sugar, reduce insulin spikes, and improve insulin sensitivity that benefits those with type 2 diabetes Debunked: This claim contradicts the evidence of induced hepatic insulin resistance and glucose intolerance in longer-term studies. In animal models, keto diets impair blood sugar regulation within several days, which shows harm for metabolic health.   Keto Claim: Ketones are seen as “clean” fuel that advocates claim are anti inflammatory and neuroprotective. Believe that this along with ketosis lowers triglycerides, raises HDL cholesterol, and improves lipid profiles. They argue that the increase in LDL cholesterol is benign. Claim saturated fats are harmless if carbs are low Debunked:  This claim is undermined by the increased LDL cholesterol, triglycerides, and cardiovascular risks from saturated fats in animal products. Meta-analyses show no long-term lipid improvements from keto diets. Rather this is the risk in elevated low-density lipoprotein and very-low-density lipoproteins that increase cardiovascular disease  Also, insulin reduction does not override the quality of fat. LDL cholesterol and ApoB, as well as atherosclerosis, increase significantly on an animal based diet. Saturated fat still remains a causal factor for cardiovascular disease.   Keto Claim: High protein and fat increases satiety and therefore reduces hunger Debunking: Weight loss is primarily from reduced intake due to satiety, not fat-burning efficiency. Long-term keto adherence often leads to weight regain with no significant sustained benefits for visceral fat or appetite control. hort term weight loss is not same as long term benefits. A study shows that weight loss at 3-6 months on a keto diet disappears by 12 months   Keto Claim: It enhances brain function and energy that then improves mental clarity and mood. Argue that animal products like eggs and organ meats provides choline and other nutrients for brain health. Debunked: There is no strong evidence for this claim. In fact keto's nutrient deficiencies and lack of fiber in the long term can lead to fatigue, constipation and in women neural tubal defects. Keto's claims are only based on short term trials.    Keto Claim: Use the evolutionary argument that humans evolved eating meat and fat – same argument the paleo folks used. Therefore, they believe keto diets align with human biology Debunked: A big study in Science in 2025 analyzed tooth enamel from skeletons of some of our oldest human ancestors, 3.5 million years ago, and found they ate predominately a plant based diet with no substantial sigh of mammalian meat. The isotopes matched herbivores (fruits, leaves and grasses, tubers, nuts, other vegetation) not carnivores.     Keto Diet Risks   It is worth noting, according to the Northwestern University Health site, there is a sizable drop out rate of participants in keto trials.   Although, there are studies that show keto does what it claims in the short term, there are no long-term human data to support their claims that an animal-based diet does this efficiently.   Important, research leans in the direction to indicate that keto's benefits – especially weight loss and glucose reduction, are transient and may not be directly related to animal food consumption itself but rather to calorie reduction and limiting glycogen.   Long term prospective studies and systematic meta analysis evaluations consistently show high red meat consumption, full-fat dairy and animal fats are associated with the following medical conditions. This is true even when carbohydrate intake is low   A good thorough study in JAMA shows that unprocessed red meat mildly increases all cause mortality – about 3-5% per 100 grams meat per day   High red and processed meat consumption increases carcinogenic N-nitroso compounds and heterocyclic amines that raise cancer risks by up to 18% per 50-100 grams/day – from meta analysis in the European Journal of Epidemiology   Dairy increases IGF-1 levels thereby too much calcium also suppressing Vitamin D and elevating prostate cancer risks by 79% per 400 gram dairy per day. Worse for processed meats that inreases risk by 21% per 20 grams/day – American Journal of Epidemiology   Red meat is linked to hormonal disruptions and carcinogens contributing breast cancer – European Journal of Cancer   Total unprocessed red meat consumption shows a modest 5% risk in pancreatic cancer per 100 grams/day. – From journal Clinical Nutrition   Many meta-analyses on meats have a relationship to stomach/gastric cancer, but processed meats are worse than unprocessed red meat. From study in Nutrients – 24 studies showed unprocessed red meat associated with gastric cancer by about 25% increase risk for every 100 grams/day.   Unprocessed red meat is linked to an 11% higher risk in overall cardiovascular disease risk due to inflammation and endothelial dysfunction. – from European Heart Journal   Saturated fats in meats increases non-HDL cholesterol and blood pressure and raises the risks of ischemic heart disease by 119% per 100 grams/day red meat – from American J Clinical Nutrition   Red meat diets reduce LDL Cholesterol much less than plant proteins and thereby increase atherosclerosis risks – from the journal Circulation   Red meats (an processed meats also in this study) contributes to insulin resistance via heme iron and raises Type 2 diabetes risks by up to 51% per 50 grams/day – International Journal Environmental Research in Public Health   Saturated fats in unprocessed red meat has a modest positive 12% increase with stroke risk – From  European Heart Journal Unprocessed poultry consumption shows a modest 4% increase in incident cardiovascular events per 100 grams/day. This is believed to be due to arachidonic acid poultry – in JAMA   Red meat contributes to sodium and saturated fat intact raising hypertension conditions by 14% per 50-100 gram/day – from journal Advanced Nutrition   Saturated fats from animal products cause lipotoxicity and insulin resistance, that promotes hepatic fat accumulation leading to non-alcoholic fatty liver disease – from Cardiovascular Development and Disease   High animal protein increases urinary calcium and acid overload leading to the formation of kidney stones – from the journal Nutrient   Animal-heavy diets have low fiber and micronutrient intake that contribute to nutrient deficiencies. Also causes constipation that can lead to immune system issues. – from the journal Nutrients   Red meat, dairy, and eggs disrupts the gut metabolism of carnitine and choline. This promotes TMAO plaque formation and inflammation that leads to atherosclerosis. – from Journal of Cardiovascular Development.   Although unprocessed meat consumption has not been adequately associated with dementia and Alzheimer's – yes, processed meats do – there are studies showing red meat is associated with “subjective cognitive decline” (SCD) which is related to precursors to dementia and Alzheimer's. A study in journal Neurology  links unprocessed red meat eaten at 1 or more servings per day to 16% higher risk in SCD.   High caloric density from saturated animal fats displaces fiber that contributes to weight gain obesity. From Neal Barnard in the American Journal of Clinical Nutrition   Animal products transmit prions that are associated with neurodegenerative disorders.  Proinflammatory compounds like TMAO are linked to neurological risks. – in International Journal of Molecular Science

In this episode of the Innovations and Clinical Implementation podcast recorded at LongevityFest 2025, host Dr. Lexi Gonzales explores the intersection of AI and gut health with Dr. Helen Messier, a physician and molecular immunologist who serves as the Chief Medical and Science Officer at Fountain Life; Dr. Leo Grady, the founder of Jona and an AI expert who previously led the team achieving the first FDA approval for an AI product in pathology; and Dr. Lawrence Kosinski, a gastroenterologist and founder of Sonar MD who is a national leader in value-based care. The panel discusses how Jona's AI platform processes over 220,000 studies to identify dysbiotic patterns that antedate clinical disease—ranging from metabolic liver disease and colon polyps to Parkinson's and cardiovascular issues linked to TMAO—thereby moving clinical focus from "symptoms to systems". The experts emphasize the mechanism of the gut-brain axis, noting that metabolites like butyrate derived from soluble fiber are essential for stabilizing the blood-brain barrier and DNA, while warning that popular GLP-1 agonists, though effective for weight loss, can "collapse" microbiome diversity and require careful monitoring.   For access to episode resources, click HERE.

To prevent America's top killer, we must reduce sodium, sugar, saturated fat, cholesterol, and foods that harm the microbiome. #HeartDiseasePrevention #DietMatters #Nutrition

Broadcast from KSQD, Santa Cruz on 12-18-2025: Dr. Dawn opens by examining how market competition is actually working in the weight loss drug sector. Novo Nordisk's Ozempic and Wegovy compete against Eli Lilly's Monjaro and ZepBound, with prices dropping nearly 50% as companies launch direct-to-consumer websites. The main barriers remain needles and refrigeration, driving development of oral versions. Novo's Wegovy pill awaits FDA approval for early 2026 launch at $150 monthly. Next-generation drugs show remarkable results: Eli's retatrutide causes 24% weight loss in 48 weeks, while Novo's Cagrisema combines semaglutide with amylin to reduce muscle loss. Pfizer paid $10 billion for Metsera's once-monthly drug despite significant side effects. A quick fiber tip suggests adding plain psyllium to morning coffee for cardiovascular and microbiome benefits. Start with half a teaspoon and work up to two teaspoons (10 grams) over several weeks to avoid gas. The prebiotic fiber improves glucose tolerance and may reduce cancer risk. UC San Diego scientists discovered why cancers mutate so rapidly despite being eukaryotic cells with protected chromosomes. The answer is chromothripsis, a catastrophic event where the enzyme N4BP2 literally explodes chromosomes into fragments. These reassemble incorrectly, generating dozens to hundreds of mutations simultaneously and creating circular DNA fragments carrying cancer-promoting genes. One in four cancers show evidence of this mechanism, with all osteosarcomas and many brain cancers displaying it. This explains why the most aggressive cancers resist treatment. Research from 2013 shows any glucocorticoid use significantly increases venous thromboembolism risk, with threefold increases during the first month of use. The risk applies to new and recurrent clots, affecting both oral and inhaled steroids, though IV poses highest risk and topical the lowest. Joint injections fall somewhere between inhaled and oral. Anyone with prior blood clots should avoid steroids except for life-threatening situations like severe asthma attacks requiring ventilation. A meta-analysis of 20 randomized controlled trials shows creatine supplementation helps older adults (48-84) maintain muscle mass when combined with weight training two to three times weekly. The supplement provides no benefit without exercise. Recommended dosing starts at 2 grams and works up to 5 grams daily. Vegans benefit most since they consume little meat or fish. Important caveat: creatine throws off standard kidney function tests (creatinine), so users should request cystatin C testing instead for accurate renal health assessment. A new JAMA study suggesting risk-based mammogram screening is fatally flawed. First, researchers offered chemopreventative drugs like tamoxifen only to the high-risk group, contaminating the study design. Second, the demographics skewed heavily toward white college-educated women, missing the reality that Black women face twice the risk of aggressive breast cancer with 40% higher mortality. Third, wild-type humans failed to follow instructions—low-risk women continued getting annual mammograms anyway while high-risk women skipped recommended extra screenings. The conclusion of "non-inferior" outcomes is meaningless given poor adherence. Stick with annual mammograms, and consider alternating with MRIs for high-risk women. The EAT-Lancet report condemns red meat based purely on observational data showing correlations with heart disease, cancer, and mortality. But people who eat lots of red meat differ dramatically from low consumers: they weigh more, smoke more, exercise less, and eat less fiber. Studies can't control for sleep quality, depression, or screen time. Notably, heavy meat eaters also die more in accidents, suggesting a risk-taking lifestyle phenotype. The inflammatory marker TMAO is higher in meat eaters, but starch is also pro-inflammatory. Eating red meat instead of instant ramen might improve health. A balanced diet with limited amounts beats epidemiology-based blanket statements. Dr. Dawn grades Dr. Oz's performance as CMS administrator. Starting at minus one for zero relevant experience, he earns plus two for promoting diet, exercise, and gut health on his show. He studied intensively after nomination, calling all four previous CMS directors repeatedly and surrounding himself with experienced staff (plus one). He finalized Medicare rules favoring prevention over surgery and earned bipartisan praise as "a real scientist, not radical" (plus one). He divested healthcare holdings but kept some blind trust interests (minus 0.5). He's developing a CMS app and partnering with Google on a digital health ecosystem (plus one), but supports ending ACA subsidies that will raise premiums for millions (minus one). He correctly promoted COVID vaccines and contradicted Trump's Tylenol-autism claims (plus one). Final score: 3.5 out of 5 possible points, the only positive score for any Trump health administrator.

Email List: ⁠⁠⁠⁠⁠https://huntershealthhacks.beehiiv.com/⁠⁠⁠⁠⁠Get My Book On Amazon: ⁠⁠⁠⁠⁠⁠https://a.co/d/avbaV48Download⁠⁠⁠⁠⁠⁠The Peptide Cheat Sheet: ⁠⁠⁠⁠⁠⁠https://peptidecheatsheet.carrd.co/⁠⁠⁠⁠⁠⁠Download The Bioregulator Cheat Sheet: ⁠⁠⁠⁠⁠⁠https://bioregulatorcheatsheet.carrd.co/⁠⁠⁠⁠⁠⁠1 On 1 Coaching Application: ⁠⁠⁠⁠⁠⁠https://hunterwilliamscoaching.carrd.co/⁠⁠⁠⁠⁠⁠Book A Call With Me: ⁠⁠⁠⁠⁠⁠https://hunterwilliamscall.carrd.co/⁠⁠⁠⁠⁠⁠Supplement Sources: ⁠⁠⁠⁠⁠⁠https://hunterwilliamssupplements.carrd.co/⁠⁠⁠⁠⁠⁠Amazon Storefront: ⁠⁠⁠⁠⁠⁠https://www.amazon.com/shop/hunterwilliams/list/WE16G2223BXA?ref_=cm_sw_r_cp_ud_aipsflist_R7QWQC0P1RACB2ETY3DY⁠⁠⁠⁠⁠⁠Socials:Instagram: ⁠⁠⁠⁠⁠⁠https://www.instagram.com/hunterwilliamscoaching/⁠⁠⁠⁠⁠⁠Video Topic Request: ⁠⁠⁠⁠⁠⁠https://hunterwilliamsvideotopic.carrd.co/⁠In this video I do a full deep dive on injectable L-carnitine—what it is, how it actually works in your body, and how I personally use it in my own optimization routine. I've been using injectable L-carnitine for years, and the longer I use it, the more it's become one of those quiet, reliable staples I always come back to for energy, performance, and longevity support.I start by breaking down the basics: L-carnitine is a naturally occurring amino acid derivative that shuttles long-chain fatty acids into the mitochondria so they can be burned for energy. When you think L-carnitine, think mitochondria, ATP, and better fuel utilization. I explain why injectable L-carnitine is so powerful compared to oral—much higher bioavailability, higher plasma levels, and you avoid some of the downsides like elevated TMAO that can show up with long-term, high-dose oral use.From there, I walk through the human data: improved exercise performance, reduced lactate, better recovery, cardiovascular support, and even a wild study in centenarians showing more muscle, less fat, and better physical function from L-carnitine supplementation. I also talk about cognitive and mood benefits, and why I stack injectable L-carnitine with acetyl-L-carnitine orally for brain health.I'm honest about side effects and trade-offs: post-injection pain, occasional lumps, and even the “fishy odor” some people notice at higher doses. I share exactly how I dose it (usually 400–500 mg IM before workouts, three to four times per week), why I prefer intramuscular over subcutaneous, and what needle size works best in the real world.I close by making the case that injectable L-carnitine isn't a magic fat burner—but it is one of the most useful, versatile tools for anyone who cares about performance, energy, and long-term health.

 Detox isn't a juice cleanse — it's a biochemical process your liver runs 24/7. In this deep-dive episode, Coach Debbie Potts unpacks how choline, bile, and cholesterol form the ultimate metabolic trio that determines your fat-burning, hormone balance, and brain health. Learn how sluggish bile flow, low choline intake, or poor drainage can stall detoxification, drive estrogen dominance, and create that "toxic fatigue" so many midlife women experience. You'll discover:

We are back in the whipping winds of the Halloween season with a very Controlled fire pillar to spin some more spooky stories and chats for the season. Best time of the year.Mitch is⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ on Letterboxd⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠.Art by Jade Dickinson: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@jadesketches⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ on Instagram | ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@jadesketches⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ on TikTokListen to the new Guest Room Status songs ⁠⁠⁠⁠⁠Stall at the Start⁠⁠⁠⁠⁠ and ⁠Losing Track⁠Listen to Liam's Weezer podcast ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠here⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Find the show on ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Instagram⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Find ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Corey⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ and ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Liam⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ on TwitterFind MK Podquest and Strat 2 ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠here⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Reach us via email: tmaopodcast@gmail.com"Eighties Action" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/by/4.0/

In part 1 of the Cardiometabolic Rx podcast, host Emma Sutherland is joined by Dr Adrian Lopresti, Dr Michelle Woolhouse, Lisa Costa-Bir, and Mick Alexander for a wide-ranging discussion on the foundations of cardiometabolic health. Together, they explore how individualised nutrition, hormonal balance, stress adaptation, and muscle and bone integrity as well as kidney health influence metabolic outcomes, emphasising why truly integrative care must extend beyond BMI, cholesterol and blood pressure checks. The panel shares the latest evidence on emerging assessment tools - including continuous glucose monitoring, homocysteine and trimethyl amine and oxide (TMAO) testing, and the body roundness index and how these measures can reveal early signs of dysfunction before overt disease develops. In an engaging exchange of clinical perspectives, the ambassadors uncover the “silent hijackers” of cardiometabolic health such as poor sleep, loneliness, medications, and gut dysbiosis. This thought-provoking discussion challenges long-held assumptions and equips practitioners with practical, evidence-based strategies to assess and address cardiometabolic risk at every stage of patient care. COVERED IN THIS EPISODE (1:07) Welcome – fx Medicine ambassadors (2:42) Cardiometabolic myth 1: “there is no one-size-fits-all when it comes to diet” (4:57) Cardiometabolic myth 2: – “I've got big bones” (7:23) Cardiometabolic myth 3: – Cardiometabolic disease is an old person's disease (10:21) Cardiometabolic myth 4: – If your BMI is normal, then your metabolic health is fine (11:19) Cardiometabolic myth 5: – People with a heart condition should avoid exercise (15:16) Cardiometabolic disease drivers – Stress and cardiovascular disease (18:07) Cardiometabolic disease driver – Complex interplay of conditions (20:10) Cardiometabolic disease driver – Muscles and bones (21:56) Cardiometabolic disease driver – Chronic kidney disease (25:20) Cardiometabolic disease driver – Lifestyle factors (35:06) Assessment tools – Waist measurement (37:29) Assessment tools – Continuous glucose monitoring (41:49) Assessment tools – Blood tests (44:12) Assessment tools – Pharmacy screening (49:33) Assessment tools – Cortisol testing (53:44) Cardiometabolic hijacker – Early childhood trauma (58:19) Cardiometabolic hijacker – Relationship between cardiometabolic and mental health (1:01:04) Cardiometabolic hijacker – Common medications (1:03:50) Cardiometabolic hijacker – Gut bacteria (1:06:52) Final remarks Find today's transcript and show notes here: https://www.bioceuticals.com.au/education/podcasts/the-cardiometabolic-rx-part-1-metabolic-fundamentals-and-myths Sign up for our monthly newsletter for the latest exclusive clinical tools, articles, and infographics: www.bioceuticals.com.au/signup/ DISCLAIMER: The information provided on fx Medicine by BioCeuticals is for educational and informational purposes only. The information provided is not, nor is it intended to be, a substitute for professional advice or care. Please seek the advice of a qualified health care professional in the event something you learn here raises questions or concerns regarding your health.

In the realest Halloween scare of all, Corey's worst nightmare has come true: unfixable technical difficulties.Mitch is⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ on Letterboxd⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠.Art by Jade Dickinson: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@jadesketches⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ on Instagram | ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@jadesketches⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ on TikTokListen to the new Guest Room Status songs ⁠⁠⁠⁠Stall at the Start⁠⁠⁠⁠ and Losing TrackListen to Liam's Weezer podcast ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠here⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Find the show on ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Instagram⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Find ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Corey⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ and ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Liam⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ on TwitterFind MK Podquest and Strat 2 ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠here⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Reach us via email: tmaopodcast@gmail.com"Eighties Action" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/by/4.0/

In this groundbreaking episode, Dr. Aaron Ernst exposes the real, hidden causes of heart disease—toxins like glyphosate, homocysteine, lead, cadmium, and TMAO—that silently inflame and poison the cardiovascular system while conventional medicine blames cholesterol. Discover how these modern poisons damage your heart at the cellular level and learn the natural, functional detox strategies that can reverse inflammation, restore vitality,and help you heal your heart from the inside out.See omnystudio.com/listener for privacy information.

Bob o7 (spoilers)"You know what grown-ups do when they make a podcast? They own up to it."Shout out to Cussler Hustlers podcast! IG @cusslerhustlersListen to Cussler Hustlers on Spotify!Subscribe to Bob's podcast: https://theflockpodcast.simplecast.com/Follow Bob on Twitch: https://www.twitch.tv/respectablestreetFollow Kenny on twitter @cyhobbezListen to Neal talk about Deathstalker II on TMAO on Spotify!SUPPORT THE PODCAST AT COOLERBOT.NETTwitter @crewexpendapod | Instagram @crewexpendablepod | Subscribe at crewexpendable.net | @crewexpendable.bsky.social |Art by IG @art_of_womtezUSCSS PODCAST Location: BOAT ★ Support this podcast ★

This week, Dr. Kahn reports on a new Mayo Clinic study on the relationship between chronic insomnia and accelerated brain aging in a group of study subjects who had advanced brain testing over time. He suggests 20 tips for better sleep and a bonus 21st: cognitive behavioral therapy for insomnia (CBT-I). Additional topics include heart disease remaining the #1 cause of death, TMAO and cognitive impairment, ATTR-cardiomyopathy, childhood blood pressure and future heart disease, niacin and optimal liver health, and the relationship between heart diseases like atrial fibrillation and cognitive decline. Thanks to igennus.com and the discount code DrKahn.  Dr. Kahn will be leading a group Fasting Mimicking Diet starting 10/5/25. Order your PROLON kit (Next Gen) at www.prolonlife.com/drkahn.

You already know Bob is here, and you already know we're SPOILING Episode 6 of Alien: Earth!RUNSCRIPT HYBRID_TRACKHYBRID TRACKERS/PODCAST MONITORS OFF? Y/NSubscribe to Bob's podcast: https://theflockpodcast.simplecast.com/Follow Bob on Twitch: https://www.twitch.tv/respectablestreetFollow Kenny on twitter @cyhobbezListen to Neal talk about Deathstalker II on TMAO on Spotify!If you want more Corey and Neal, go listen to MK PODQUEST!: https://mkpodquest.transistor.fm/SUPPORT THE PODCAST AT COOLERBOT.NETTwitter @crewexpendapod | Instagram @crewexpendablepod | Subscribe at crewexpendable.net | @crewexpendable.bsky.social |Art by IG @art_of_womtezUSCSS PODCAST Location: The Maginot, but things aren't looking good. ★ Support this podcast ★

This week, Dr. Joel Kahn reviews the latest research on men's health, focusing on diet and prostate cancer. He highlights findings that support whole-food, plant-based diets and discusses the connection between prostate cancer, heart disease, and the cardiovascular risks associated with androgen deprivation therapy (ADT). Other topics covered include plant-based diets and disease rates, the role of LDL cholesterol in soft plaque formation, TMAO in abdominal aortic aneurysms and kidney disease, periodontal disease and its impact on heart health, saccharin and cardiovascular risk, extreme physical activity and carotid plaque, and the effects of Tylenol use during pregnancy.  Dr. Kahn also reviews new research on cyclodextrin suppositories, a paper examining the impact of statins on blood sugar, and the potential role of TUDCA as a possible antidote.  Resources mentioned in this episode include the cyclodextrin paper available at www.atherocare.com/drjoelkahn and details on TUDCA at https://shop.drjoelkahn.com/catalog/product/view/id/17560/s/tudca-tauroursodeoxycholic-acid-60-capsules/. Special thanks to our sponsor Igennus.com, use discount code DrKahn for all products.

In this episode of the Gladden Longevity Podcast, Dr. Jeffrey Gladden speaks with Dr. Robin Rose about her personal journey with kidney cancer and her insights into kidney health. They discuss the importance of understanding kidney function, the role of peptides and bioregulators in improving kidney health, and the impact of lifestyle choices on kidney function. Dr. Rose emphasizes the need for a positive mindset and proactive measures to optimize kidney health, including dietary changes and the use of specific peptides. The conversation also touches on the significance of measuring kidney function and the effects of toxins and TMAO on overall health.   For Audience ·       Use code 'Podcast10' to get 10% OFF on any of our supplements at https://gladdenlongevityshop.com/ !    Takeaways ·       Dr. Robin Rose shares her personal journey with kidney cancer. ·       Understanding GFR is crucial for assessing kidney function. ·       Peptides can play a significant role in kidney health. ·       Bioregulator peptides help reverse kidney decline. ·       A positive mindset is essential for health improvement. ·       Lifestyle changes are necessary for kidney optimization. ·       Toxins in food can negatively impact kidney health. ·       TMAO is linked to cardiovascular risks in kidney disease. ·       Regular monitoring of kidney function is important. ·       Self-love and care are vital for health management.   Chapters 00:00 Introduction to Kidney Health and Personal Journey 06:08 The Role of Lifestyle in Kidney Health 10:42 Bioregulator Peptides and Kidney Success 16:25 Innovative Strategies for Kidney Health 25:35 The Role of Peptides in Health 32:33 Kidney Function and Circadian Rhythms 39:10 Oxidative Stress and Inflammation in Kidney Health 45:00 Dietary Considerations for Kidney Health 49:33 Resources for Kidney Health and Patient Empowerment   To learn more about Robin: Email:  rosegardenmedicine@gmail.com Website: renologyiskidneysuccess.com   Reach out to us at:    Website: https://gladdenlongevity.com/     Facebook: https://www.facebook.com/Gladdenlongevity/    Instagram: https://www.instagram.com/gladdenlongevity/?hl=en     LinkedIn: https://www.linkedin.com/company/gladdenlongevity    YouTube: https://www.youtube.com/channel/UC5_q8nexY4K5ilgFnKm7naw    

Become a FoundMyFitness Premium Member to access the full episode In this special episode, you'll get an exclusive 30-minute preview of my latest Ask Me Anything (AMA) session, normally reserved for FoundMyFitness Premium Members. Each month, Premium Members join me live to receive direct answers to their most pressing questions on nutrition, supplements, longevity, sleep, fitness—no topic is off-limits. In today's sneak peek, you'll hear why I've started taking exogenous ketones, details about my personal coffee routine (from bean choices to brewing methods), optimal supplement dosages (including ubiquinol, berberine, and vitamin K2), and whether some popular greens powders might pose risks due to heavy metals. Learn more here about becoming a FoundMyFitness Premium Member for as little as $15 per month. After signing up, you'll also unlock the full 90-minute session, along with more than 100 hours of additional AMA content. Your membership directly supports our mission to deliver trustworthy, unbiased, science-backed health information that's entirely ad-free and free from commercial bias. Every Premium Member helps us stay focused solely on providing you with the highest-quality insights grounded in rigorous science. Timestamps: (00:00) Introduction (02:44) Why I started taking exogenous ketones (04:02) What ketone supplement brand am I using? (07:16) Can ketones help reduce performance anxiety? (08:50) My daily coffee routine (beans, brewing, and tips) (11:31) Should you worry about diterpenes in coffee? (12:56) Which coffee bean brand do I trust most? (14:04) Does coffee cause dehydration or block mineral absorption? (15:46) Is drinking coffee on an empty stomach harmful? (16:01) Does dairy reduce coffee's polyphenol benefits? (17:53) Should slow caffeine metabolizers avoid coffee? (18:52) Can coffee's vasoconstriction affect brain blood flow? (19:18) Do coffee pods release harmful microplastics? (20:09) The ketone meter I've relied on for 10 years (20:35) Does quitting caffeine lower resting heart rate? (20:41) What's the best plastic-free coffee maker? (21:13) Ideal dosing for ubiquinol, berberine, and alpha-lipoic acid (22:43) Which supplements best support fertility and egg quality? (23:49) Why (and how much) myo-inositol did I take? (24:08) Am I still taking benfotiamine, collagen, lutein, and zeaxanthin? (24:34) Creatine vs. methylated B vitamins for homocysteine control (25:56) Which vitamin K2 supplement (and dosage) do I use? (26:17) Are greens powders (like moringa) high in heavy metals? (27:16) Which choline supplement won't raise TMAO? (30:31) Which Thorne supplements do I personally use? (30:44) How much CoQ10 is needed if you're not targeting fertility?

Another year in the books here on TMAO and so another retrospective is upon us. We have suspicions that we're set to have radically different lists for the year... but maybe we agree more than expected? Let's find out.Mitch is⁠⁠ on Letterboxd⁠⁠⁠⁠⁠⁠Art by Jade Dickinson: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@jadesketches⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ on Instagram | ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@jadesketches⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ on TikTokListen to Liam's Weezer podcast ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠here⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Listen to ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠"Like the Weather,"⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ the new EP from Liam's band Guest Room StatusFind the show on ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Instagram⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Find ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Corey⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ and ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Liam⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ on TwitterFind MK Podquest and Strat 2 ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠here⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Reach us via email: tmaopodcast@gmail.com"Eighties Action" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/by/4.0/

Mitch is, uh, not happy with us about this, to say the least. For the first time ever, let's revisit a film on TMAO. Welcome to Black Christmas in July.Mitch is⁠ on Letterboxd⁠⁠⁠⁠⁠Art by Jade Dickinson: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@jadesketches⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ on Instagram | ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@jadesketches⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ on TikTokListen to Liam's Weezer podcast ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠here⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Listen to ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠"Like the Weather,"⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ the new EP from Liam's band Guest Room StatusFind the show on ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Instagram⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Find ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Corey⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ and ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Liam⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ on TwitterFind MK Podquest and Strat 2 ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠here⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Reach us via email: tmaopodcast@gmail.com"Eighties Action" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/by/4.0/

In today's episode we'll talk about L-Carnitine.  What is L-carnitine, what does it do, and why are more people choosing to inject it instead of taking it as a pill? Let's break it down.  L-carnitine is a compound made from the amino acids lysine and methionine, and its main job is helping your body turn fat into energy by shuttling fatty acids into your cells' mitochondria. While we naturally make some and get more from foods like red meat and dairy, certain people — like athletes, older adults, or those with metabolic issues — may not make or absorb enough. That's where supplementation, especially the injectable form, comes in. Why inject L-carnitine instead of taking it by mouth? This is a question I get all the time. Yes, you can take L-carnitine as a pill or powder. But here's the catch: when you take it orally, your body only absorbs about 15 to 20% of it. That means you'd need to take a whopping 4 to 5 grams daily just to get a therapeutic dose — and that often comes with unpleasant side effects, like bloating, diarrhea, and even that infamous fishy body odor, thanks to a byproduct called trimethylamine. Injectable L-carnitine skips all that. It's way more bioavailable — so you actually absorb and use what you inject. It's faster-acting, especially when you give it intramuscularly. And it's also easier on the gut, since it bypasses digestion and liver metabolism. With the injectable form, you get more targeted results, which is great for things like fat loss, athletic performance, or metabolic health. What are the potential benefits of L-carnitine? Let's talk about what L-carnitine actually does in your body—because honestly, it's pretty impressive.  First off, it helps you burn fat more efficiently by moving fatty acids into your cells' mitochondria to be used for energy. It can also boost endurance by delaying fatigue, and it supports faster recovery by reducing soreness and muscle damage after tough workouts.  On top of that, it improves blood flow and oxygen delivery to your muscles, which can lead to better pumps and overall performance. It even helps keep fat from building up in organs like your liver and heart, which is great for metabolic health. L-carnitine also plays a role in boosting metabolism and improving insulin sensitivity, especially for those with blood sugar issues. Some studies suggest it can support mental focus and even help with heart function in people with heart conditions. Not bad for a single supplement, right? What about dosing? Injectable L-carnitine doses usually fall between 200 to 1,000 mg per day, though some people aiming for fat loss or performance might go as high as 2,000 mg. Most people split the dose to make injections more comfortable and keep levels steady—like 500 mg in each shoulder, or half in the morning and half before a workout.  Timing really does matter, too. It tends to work best first thing in the morning when your body's ready to burn fat, or about 30 to 60 minutes before training when you need a boost in energy and fat oxidation. Just avoid taking it too late, since it can be pretty stimulating and might mess with your sleep. What are the potential side effects of L-carnitine? Overall, injectable L-carnitine is pretty well tolerated, but like anything, it's not completely free of side effects.  Some people might notice redness or soreness at the injection site, especially if their technique isn't spot-on. Mild nausea or headaches can pop up too, but they're usually short-lived and related to the dose.  That fishy body odor we talked about earlier? It's less common with injections than with pills, but it can still happen if your body has trouble breaking down carnitine. Taking it too late in the day might lead to insomnia since it ramps up your energy, and some folks notice an increased appetite—probably because their metabolism is kicking into high gear.  And if you're not staying hydrated or your electrolytes are off, you might get muscle cramps. Who shouldn't take L-carnitine? L-carnitine can be super helpful for energy and fat metabolism, but it's not right for everyone.  If you have low thyroid function, it might actually make your symptoms worse because it can interfere with how your body uses thyroid hormones. People with a history of seizures should also be cautious, since L-carnitine may increase seizure risk. And while it has some benefits for heart health, there's some debate about whether it could raise certain byproducts like TMAO that might increase heart disease risk—especially in people who already have heart issues. It can also interact with medications like warfarin, so if you're on a blood thinner, definitely check with your provider.  Also, anyone with kidney or liver problems should use it carefully, too, since those organs help process and eliminate it. Oh, and if you're pregnant, breastfeeding, or prone to insomnia, it's best to hold off or talk with your doctor first. Bottom line: L-carnitine can do a lot of good, but it's always smart to make sure it's the right fit for your body. That said, it's not for everyone. Dosing, timing, and safety all matter — so always work with a knowledgeable provider. Thank you for listening to The Peptide Podcast. If you enjoyed the show and want to support what we do, head over to our Partners Page. You'll find some amazing brands we trust—and by checking them out, you're helping us keep the podcast going.  Have a happy, healthy week!

Story at-a-glance A specific gut microbiome pattern was found to help predict future heart attacks in coronary heart disease patients, offering a new tool beyond cholesterol and blood pressure monitoring Researchers identified 10 key bacterial strains tied to heart attack risk and created a scoring system that flags high-risk individuals before symptoms appear Patients with high-risk gut profiles showed more inflammation, insulin resistance, and higher levels of dangerous compounds like trimethylamine N-oxide (TMAO) and endotoxins Global research confirms gut bacteria influence heart disease through microbial metabolites like short-chain fatty acids, bile acids, and lipopolysaccharide-related immune responses Natural interventions like berberine, dietary shifts, and fecal transplants show promise in reshaping gut health and reducing cardiovascular risk

LDL cholesterol, apoprotein B, saturated fat, TMAO, statin cholesterol drugs: Over the last 40 years, we have been inundated with misguided advice on how to reduce your risk for coronary heart disease, i.e., risk for such things as heart attack, need for heart procedures such as stent implantation or bypass surgery, or sudden cardiac death, serious and often life-threatening events. Has it worked? 80 million Americans now take statin drugs to reduce cholesterol yet there has been no meaningful reduction in such events and, in fact, I'll bet some of your local hospitals have added multi-million dollar wings for cardiac care, the number one moneymaker for hospitals and healthcare. The tragedy of all this is that the focus on issues like cholesterol have taken everyone's focus off the REAL causes of heart disease that are, in reality, easy to identify and manage. And it involves no pharmaceuticals, no restriction of dietary fat, but draws from a handful of common sense and natural strategies that, time and again, have allowed people to stop or even reverse coronary atherosclerosis. _________________________________________________________________________________For BiotiQuest probiotics including Sugar Shift, go here.A 15% discount is available for Defiant Health podcast listeners by entering discount code UNDOC15 (case-sensitive) at checkout.*_________________________________________________________________________________Get your 15% Paleovalley discount on fermented grass-fed beef sticks, Bone Broth Collagen, low-carb snack bars and other high-quality organic foods here.* For 12% off every order of grass-fed and pasture-raised meats from Wild Pastures, go here._____________________________________________________________________________MyReuteri and Gut to Glow can be found here: oxiceutics.comSupport the showBooks: Super Gut: The 4-Week Plan to Reprogram Your Microbiome, Restore Health, and Lose Weight Wheat Belly: Lose the Wheat, Lose the Weight and Find Your Path Back to Health; revised & expanded ed

Jennifer Moore discusses how plant-based solutions can prevent the progression of kidney disease. Learn about dietary changes that support kidney health and overall wellness. #KidneyHealth #PlantBasedSolutions #Wellness

Vidcast:https://www.instagram.com/p/DF_AxX3RDOw/Regularly consuming hot dogs and bacon could increase your chances of developing dementia by 13%. Eating those steaks consistently leads to a 16% higher risk of cognitive decline.  A new study by researchers from Mass General Brigham and the Harvard School of Public Health followed more than 133,000 (133,771) individuals for up to 43 years.As few as two slices of bacon consumed regularly accelerates your cognitive aging by 1.6 years and triggers a cognitive decline that is an early marker of dementia.  Why?  Saturated fats, salt, and a gut-derived compound called TMAO, trimethylamine N-oxide, are the brain-damaging culprits.The good news.  Substituting fish, nuts, or legumes for the franks, bacon, and t-bones could reduce your dementia risk by 19%.https://www.massgeneralbrigham.org/en/about/newsroom/press-releases/red-meat-increases-risk-of-dementiahttps://www.neurology.org/doi/10.1212/WNL.0000000000210286#dementia #redmeat #bacon #hotdogs #tmao

Dr. Pedi Mirdamadi is a Licensed Naturopathic Doctor and Holistic Nutritionist specializing in Functional Medicine, practicing at Oasis Health and Medicine in San Diego. After earning his undergraduate degree from the University of Toronto, Dr. Pedi earned his Master of Science in Kinesiology at York University and became a Registered Holistic Nutritionist (RHN) at the Canadian School of Natural Nutrition. He graduated as a Naturopathic Doctor at Bastyr University California and has received training from leaders in functional medicine, the Institute of Functional Medicine and is an Institute of Functional Medicine Certified Practitioner. In our discussion, Dr. Pedi and I explore gut health, cardiometabolic health, and some business talk about his large social media following. He highlights common stress patterns that are negatively impacting digestive health, the connection between cardiovascular health and GI health, and tests, lab markers, and other considerations for Dr. Pedi's personalized nutrition plans. He answers some of the questions he hears most frequently, including what makes a good diet, why people are sicker than ever, and the biggest overlooked issues in cardiovascular health.  He also highlights the power of social media in educating the public and reaching millions of potential patients and clients daily.    I'm your host, Evelyne Lambrecht, thank you for designing a well world with us.   Episode Resources: Dr. Pedi Mirdamadi - https://drpedinaturalhealth.com/about/ Design for Health Resources: Designs for Health - https://www.designsforhealth.com/ Designs for Health Practitioner Exclusive Drug Nutrient Depletion and Interaction Checker - https://www.designsforhealth.com/drug-nutrient-interaction/ Visit the Designs for Health Research and Education Library which houses medical journals, protocols, webinars, and our blog. https://www.designsforhealth.com/research-and-education/education The Designs for Health Podcast is produced in partnership with Podfly Productions. Chapters: 00:00 Intro. 01:24 Rebuilding his health has been lighting Dr. Pedi up in the new year.  2:32 Pedi journey toward practicing functional medicine began as a personal trainer.  4:41 Common stress patterns that are negatively impacting digestive health.  5:46 Lab findings regularly show an increasing presence of H. pylori. Dr. Pedi offers natural treatment options. 9:27 People seem to be sicker than ever before. Is it caused by a weakened GI or weakened immune issues?  11:15 Dr. Pedi's favorite gut health nutrients to target whole health and healing.  13:50 Applications for post biotics including addressing leaky gut.  14:30 The connection between cardiovascular health and GI health, and TMAO considerations.  19:20 What does a good diet include? The answer can be both personalized and generalized.  22:07 Lab markers and other considerations for Dr. Pedi's personalized nutrition plans. 24:36 Addressing histamine intolerance and stabilizing mast cell response.  26:55 Dr. Pedi's interactions with Dr. Mimi Guarneri greatly shaped his journey as a doctor. 33:15 Clinical patterns that are found in stool testing for the GI and cardiology connection.  34:05 Sleep apnea is one of the biggest overlooked issues in cardiovascular health.  40:43 The connection between oral health and cardiovascular health.  41:46 Supplement recommendations for increased cardiovascular health.  42:16 Dr. Pedi highlights all that social media has allowed naturopathic doctors to accomplish.  46:00 The power of consistently posting helpful marketing information on social media.  50:08 Key lessons learned in building a business.  52:25 Pedi's personal favorite supplements, favorite health practices, and the approach to healing that he has changed his mind about in recent years.

This Real Science Exchange podcast episode was recorded during a webinar from Balchem's Real Science Lecture Series. You can find it at balchem.com/realscience.Feeding rumen-protected choline in early lactation has consistently increased milk yield and energy-corrected milk yield, which is more pronounced when cows are fed diets low in metabolizable methionine. Choline feeding also increases milk fat and protein yield, minimizes body condition loss in early lactation, and reduces postpartum disease incidence. Dr. McFadden presents three topics about choline biology in the dairy cow. (01:45)Why should we consider fatty acid feeding when feeding methyl donors like choline and methionine?Choline degradation in the rumen and small intestine, focusing on the role of triethylamine oxide Why should we consider lysophosphatidylcholine as an immunomodulator in fresh cows and preweaning calves?Fatty acid nutrition to optimize methyl donor efficiency. (4:02)Fatty liver is a concern for fresh cows because of its relationship with ketosis, poor fertility and compromised milk production. Cows with fatty liver exhibit low circulating concentrations of phosphatidylcholine, which is a component of very low-density lipoproteins (VLDL) that transport triglycerides out of the liver. Feeding rumen-protected choline lowers liver triglyceride deposition by supporting the synthesis of phosphatidylcholine and thus, VLDL. Dr. McFadden goes on to explain the two different pathways for phosphatidylcholine in the liver and how those interact with fatty acid metabolism. He describes several experiments that have investigated how rumen-protected choline and supplemental fatty acids interact in lactating cows. Low phosphatidylcholine supply is a key feature of fatty liver in dairy cows, likely due to low polyunsaturated fatty acid (PUFA) and low choline supplies. Delivery of post-ruminal PUFA may support phosphatidylcholine synthesis with accompanying improvements in insulin sensitivity, body condition maintenance, and inflammation, but interactions with dietary fatty acid digestibility should be considered. Dr. McFadden gives a list of considerations for fresh cow diets incorporating fat and choline supplementation. Gastrointestinal choline degradation and trimethylamine N-oxide (TMAO)  (16:58)Unprotected choline is almost totally degraded in the rumen. Microbes convert choline into trimethylamine (TMA) which is then converted to TMAO in the liver. Rumen-protected choline allows for a large proportion of choline to reach the small intestine intact. However, research shows that choline can also be degraded by microbes in the small intestine in the same pathway, limiting choline bioavailability. Plasma TMAO accumulation is associated with non-alcoholic fatty liver disease, inflammation, insulin resistance, obesity, oxidative stress, and cardiovascular disease in rodent and human models. Little research was available regarding if the relationship between TMAO and poor health was causative or just associative. Dr. McFadden's lab infused cows intravenously with TMAO and found that TMAO did not modify milk production or glucose tolerance in early lactation cows.  TMAO does not appear to influence energy metabolism or health in early lactation cows. Choline is subject to both ruminal and lower-gut degradation to TMA, and that influence on choline bioavailability needs to be defined. Data in non-ruminants suggests that unsaturated fatty acid feeding can shift the gut microbes to slow TMA formation. Lysophosphatidylcholine and immunomodulation (28:45)Dr. McFadden gives an overview of neutrophil activation and the oxidative burst that contributes to pathogen killing. The ability to elicit the oxidative burst is diminished in pre-weaned calves and transition cows. When cows were given endotoxin to cause an immune response, circulating lysophosphatidylcholine was decreased. In rodent models, lysophosphatidylcholine promotes the oxidative burst and suppresses long-term inflammation in response to bacterial infection. Dr. McFadden cultured neutrophils from pre-weaned calves with lysophosphatidylcholine and observed an enhanced oxidative burst.Immunosuppression is characterized by low circulating lysophosphatidylcholine concentrations in dairy cows. In  vitro data suggests lysophosphatidylcholine can activate neutrophils, and rumen-protected choline increases circulating lysophosphatidylcholine. Future research is likely to define an immunomodulatory role for choline. Dr. McFadden takes questions from the webinar audience. (38:07)Please subscribe and share with your industry friends to invite more people to join us at the Real Science Exchange virtual pub table.  If you want one of our Real Science Exchange t-shirts, screenshot your rating, review, or subscription, and email a picture to anh.marketing@balchem.com. Include your size and mailing address, and we'll mail you a shirt.

Delving into the science behind Trimethylamine N-oxide (TMAO) and its potential link to cardiovascular disease.Mentioned in this episode: Soluble Dietary Fiber Reduces Trimethylamine Metabolism via Gut Microbiota and Co-Regulates Host AMPK Pathways | National Library of Medicine | 2017 Dec (nbci.nlm.nih.gov)Dietary fiber intervention modulates the formation of the cardiovascular risk factor trimethylamine-N-oxide after beef consumption: MEATMARK – a randomized pilot intervention study (Cold Spring Harbor Labratory)Diet, Fecal Microbiome, and Trimethylamine N-Oxide in a Cohort of Metabolically Healthy United States Adults (MDPOI)A randomized crossover trial on the effect of plant-based compared with animal-based meat on trimethylamine-N-oxide and cardiovascular disease risk factors in generally healthy adults | National Library of Medicine | 2020 Nov (nbci.nlm.nih.gov) Nutrition Diva is hosted by Monica Reinagel, MS, LDN. Transcripts are available at Simplecast.Have a nutrition question? Send an email to nutrition@quickanddirtytips.com or leave a voicemail at 443-961-6206.Follow Nutrition Diva on Facebook and subscribe to the newsletter for more diet and nutrition tips. Find Monica's blog and other programs at Nutrition Over Easy. Nutrition Diva is a part of the Quick and Dirty Tips podcast network. LINKS:Transcripts: https://nutrition-diva.simplecast.com/episodes/Facebook: https://www.facebook.com/QDTNutrition/Newsletter: https://www.quickanddirtytips.com/nutrition-diva-newsletterNutrition Over Easy: https://nutritionovereasy.comQuick and Dirty Tips: https://quickanddirtytipscom

In this episode, Dr. Kahn dives into the latest research on healthy fats and lifespan, the link between untreated hypertension and dementia risk, red meat's connection to colon cancer, and the role of TMAO in heart failure. He also discusses why ApoB might be a better cholesterol test. The main focus is on astaxanthin, a potent carotenoid antioxidant derived from microalgae, which is difficult to source from plant foods. Astaxanthin offers significant health benefits, from supporting brain health to protecting the heart. A promising study on astaxanthin's impact on congestive heart failure is also highlighted. Dr. Kahn proudly offers a premier brand of plant-based astaxanthin: Astaxanthin Complex.

Dr. Joel Kahn emphasizes the importance of staying hydrated during these hot summer months and suggests adding trace mineral drops to your glass or stainless steel water bottle. Get your trace minerals here. In this week's "pea-cast," Dr. Kahn shares intriguing case studies from the Kahn Center, highlighting two common supplements for optimal health: Arterosil and Homocysteine Supreme. He also discusses a study on spirulina in patients hospitalized with Covid-19 and offers a 20% discount at EnergyBits with the code DrKahn.  The main topic revisits Dr. Kahn's appearance on the Joe Rogan Experience in 2018 (episode 1175), where he discussed TMAO content in fish. Recent data from the Cleveland Clinic shows that some fish, such as those found in fish sticks (cod and haddock) and wild-caught salmon, can be high in TMAO, raising blood levels and increasing the risk of the ill effects of high TMAO levels. Many, including Dr. Kahn and his wife, choose to avoid fish altogether.

Every year it seems like wellness trends get weirder and weirder and it is hard to sift through what is legitimate and what is snake oil. Tune in to hear us answer recent questions about Methylene Blue, TMAO, Shilajit and Hydrogen Water.    If you're wondering about recent health trends like methylene blue and shilajit, listen to this episode to hear us discuss these and whether you need to get on the bandwagon. We delve into current research, pros and cons, and considerations of who should not try these. Plus we discuss TMAO and whether you need to be worried about animal protein raising this market and we get into whether hydrogen water is the next big thing.    Also in this episode:  Methylene BlueBerberine Boost Bio-C Plus Cellular Antiox Ben Greenfield on Methylene Blue TMAOEpisode 384 You Are What You Eat Beat the Bloat Bundle Probiotic Challenge Protocol 10 Day Real Food Detox PhytoFiber Soluble Dietary Fiber Reduces Trimethylamine Metabolism via Gut Microbiota and Co-Regulates Host AMPK Pathways Non-lethal inhibition of gut microbial trimethylamine production for the treatment of atherosclerosis  ShilajitClinical evaluation of purified Shilajit on testosterone levels in healthy volunteers  Fulvic Minerals Wild Foods Hydrogen WaterMolecular hydrogen: a preventive and therapeutic medical gas for various diseases Molecular hydrogen regulates gene expression by modifying the free radical chain reaction-dependent generation of oxidized phospholipid mediators Effects of drinking hydrogen-rich water on the quality of life of patients treated with radiotherapy for liver tumors Hydrogen Water: Extra Healthy or a Hoax?—A Systematic Review Naturally Nourished Episode 292 All About Water: Reverse Osmosis  Aquatru.com use code ALIMILLERRD   This episode is sponsored by: Noble Origins, an animal-based organs focused company serving up Nose-To-Tail Protein With Organs, Collagen, & Colostrum. Our Noble Organs Complex is a powdered blend of high-quality beef organs from New Zealand-sourced grass-fed Beef liver, heart, kidney, pancreas, and spleen. Bring Nose-to-tail nutrition to the masses that need it most: Americans. We do this through a delicious once-a-day shake that the whole family can love. Check it out here and use code ALIMILLERRD at checkout.

Have you heard the buzz about the new Netflix docuseries, You Are What You Eat? Has another friend told you they are thinking about going vegan “for health reasons”? Not to worry, we watched the docuseries and read the study so you don't have to! Tune in to hear us give our hot take on the Vegan vs. Omnivore Identical Twin study.    In this episode, we respond to the Stanford Vegan Twin study and the docuseries that came out of it. We cover the actual results of the study which were not impressive, how the results were misconstrued in the docuseries, and what actually happened to study participants in terms of their metabolic health and body composition! Plus we discuss B-12 deficiency, why TMAO isn't as simple as the docuseries makes it out to be, and why we always have to follow the money when it comes to pieces like this.    Also in this episode:  Beat the Bloat Live Program - Starts April 10th! Episode 42: Transitioning from Vegan Episode 51 What the Hell?! A Rebuttal to What the Health  Episode 162: Holiday Gift Guide and Vegan Rant Episode 165: Vegan Diet a win for the Processed Food Industry (Game Changers Documentary) Cardiometabolic Effects of Omnivorous vs Vegan Diets in Identical Twins: A Randomized Clinical Trial Why LDL is a Poor Indicator for Cardiovascular HealthEpisode 157 Cholesterol as Medicine Episode 333 Understanding the Heart with Dr Stephen Hussey Oreo Cookie Treatment Lowers LDL Cholesterol More Than High-Intensity Statin therapy in a Lean Mass Hyper-Responder on a Ketogenic Diet: A Curious Crossover Experiment B-12 Deficiency on a Vegan DietB-12 Boost lozenge  Muscle Mass Loss on a Vegan Diet What TMAO Actually Measures Why the Libido “Study” Was Just Weird Bunk Environmental Arguments for a Vegan DietSources of Greenhouse Gas Emissions | US EPA Conflicts of Interest   Sponsors for this episode:  This episode is sponsored by Wild Foods, a company that puts quality, sustainability, and health first in all of their products. They have everything from coffee to turmeric to medicinal mushrooms, and every single product is painstakingly sourced from small farms around the globe. They take their mission seriously to fix the broken food system, and believe real food is medicine. They've partnered with us to give you guys an exclusive discount, so use the code ALIMILLERRD for 12% off your order at WildFoods.co! 

In this episode, we're joined by Dr. Kyle Gillett, who is passionate about offering comprehensive, personalized care to his patients. His medical practice spans a variety of areas including preventative care, aesthetics, sports medicine, hormone optimization, obstetrics, infertility, integrative medicine, and precision medicine, which incorporates genomics. Dr. Gillett views every individual as unique, deserving of care that addresses their physical, mental, and spiritual health. He emphasizes the importance of working together with his patients to make decisions based on solid evidence. He strongly advocates for the principles that "food is medicine" and "exercise is medicine." Dr. Gillett highlights what he calls the "7 pillars of health": exercise, diet, sleep, stress management, social connections, exposure to sunlight, and spiritual wellness, believing these elements are more effective than any drug or supplement. Outside of his professional life, he loves spending time outdoors on his farm with his wife, their two sons, and their two wolfhounds.In this episode, Kyle and I discuss:What are peptides?Vascular Endothelial Growth Factor (VEGF)Selective Androgen Receptor Modulator (SARM)Dehydroepiandrosterone (DHEA)Who should be taking peptides?0:00 Coming up…0:52 Introduction2:07 Unexplained infertility11:40 L-CARNITINE increase TMAO?14:57 What are peptides?19:54 Vascular Endothelial Growth Factor (VEGF)22:00 What are skin peptides?24:44 Selective Androgen Receptor Modulator (SARM)28:52 DHEA is the fountain of youth hormone38:24 Who should be taking peptides?44:27 EndingKyle's Links and Resources:Website: https://kylegillettmd.com/Instagram: https://www.instagram.com/kylegillettmd/X: https://twitter.com/gilletthealthLinkedIn: https://www.linkedin.com/in/kylegillettmd/Unlock the knowledge of trusted creators at: https://dexa.ai/Research report - Dehydroepiandrosterone (DHEA) protects hippocampal cells from oxidative stress-induced damageThe Neuro Athletics Newsletter: https://bit.ly/3ewI5P0 Instagram: https://www.instagram.com/louisanicola_/ Twitter : https://twitter.com/louisanicola_The Neuro Experience Podcast is proud to have hosted: Dr Layne Norton, Thomas DeLauer, Shawn Stevenson, Dr. Rocio Salas-Whalen, Saad Alam, Uma Naidoo, Dr. Lanna Cheuck,  Angela Lee Pucci, Jillian Turecki,  Dr. Jordan Feigenbaum, Dr. Darren Candow,  Dr. Sue Varma, Evy Poumpouras, Dr Casey Means, Renee Deehan, Dr Chris Palmer, Dr Charles Brenner. Sponsor:Bon Charge: -CODE NEURO 15% OFFThe Neuro Athletics Newsletter Instagram: louisanicola_Twitter : louisanicola_YouTube: Louisa Nicola

In this episode, we're joined by Dr. Kyle Gillett, who is passionate about offering comprehensive, personalized care to his patients. His medical practice spans a variety of areas including preventative care, aesthetics, sports medicine, hormone optimization, obstetrics, infertility, integrative medicine, and precision medicine, which incorporates genomics. Dr. Gillett views every individual as unique, and deserving of care that addresses their physical, mental, and spiritual health. He emphasizes the importance of working together with his patients to make decisions based on solid evidence. He strongly advocates for the principles that "food is medicine" and "exercise is medicine." Dr. Gillett highlights what he calls the "7 pillars of health": exercise, diet, sleep, stress management, social connections, exposure to sunlight, and spiritual wellness, believing these elements are more effective than any drug or supplement. Outside of his professional life, he loves spending time outdoors on his farm with his wife, their two sons, and their two wolfhounds. 0:00 Coming up… 0:52 Introduction 2:07 Unexplained infertility 11:40 L-CARNITINE increase TMAO? 14:57 What are peptides? 19:54 Vascular Endothelial Growth Factor (VEGF) 22:00 What are skin peptides? 24:44 Selective Androgen Receptor Modulator (SARM) 28:52 DHEA is the fountain of youth hormone 38:24 Who should be taking peptides? 44:27 Ending Kyle's Links and Resources: Website: https://kylegillettmd.com/ Instagram: https://www.instagram.com/kylegillettmd/ X: https://twitter.com/gilletthealth LinkedIn: https://www.linkedin.com/in/kylegillettmd/ Unlock the knowledge of trusted creators at: https://dexa.ai/ Research report - Dehydroepiandrosterone (DHEA) protects hippocampal cells from oxidative stress-induced damage The Neuro Athletics Newsletter: https://bit.ly/3ewI5P0 Instagram: https://www.instagram.com/louisanicola_/ Twitter : https://twitter.com/louisanicola_ *** The Neuro Athletics Newsletter: https://bit.ly/3ewI5P0 Instagram: https://www.instagram.com/louisanicola_/ Twitter : https://twitter.com/louisanicola_ Learn more about your ad choices. Visit megaphone.fm/adchoices

A metabolic pathway study on an ocean floor compound led marine scientist Veronika Kivenson straight to our gut. When she found evidence that a genetic code expansion utilized for metabolism in an ocean sediment compound also appears in the human gut, she knew she needed to understand this pathway better. Listen and learn How both the human gut and ocean sediment have an amino acid that converts trimethylamine (TMA), What trimethylamine presence has to do with plant-based versus animal-based diets and the importance of gut health, and How these findings might lead to understanding the impact and function of gut bacteria like Bilophila have on preventing arterial plaque buildup.  Veronika Kivenson recently received her Ph.D. in Marine Science from UC Santa Barbara and is now working on a post doc at Oregon State University. She studies microorganism and how they react with their surroundings, especially their metabolism, and what they consume and produce. While studying marine sediment, she came across an interesting connection with gut metabolism. An amino acid that converts from a stop codon in order to metabolize trimethylamine appears in both places. Furthermore, trimethylamine is listed in the negative column in animal-based diet pros and cons. Animal-based foods are a major source of trimethylamine. In our liver, it becomes trimethylamine-N-oxide, or TMAO, which causes plaque, an element of cardiovascular disease symptoms. But if a pathway in the gut can prevent that formation of TMAO, that's significant. Veronika Kivenson is looking at the potential beneficial role in the genetic code expansion pathway that consumes and prevents TMA from becoming TMAO, or part of plaque formation. What's really interesting is that this consuming bacteria is also associated with meat consumption. The Bilophila genus bacteria, through genetic code expansion, prevents the formation of the harmful TMAO. Studies on these pathways could lead to probiotic therapies to address cardiovascular disease. Take advantage of a 5% discount on Ekster accessories by using the code FINDINGGENIUS. Enhance your style and functionality with premium accessories. Visit bit.ly/3uiVX9R to explore latest collection. Episode also available on Apple Podcasts: apple.co/30PvU9C