Podcasts about zeef

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.03.31.535067v1?rss=1 Authors: Jokl, E., Mullan, A., Simpson, K., Birchall, L., Pearmain, L., Martin, K., Pritchett, J., Shah, R., Hodson, N., Williams, C., Camacho, E., Zeef, L., Donaldson, I., Athwal, V., Hanley, N., Piper Hanley, K. Abstract: Myofibroblasts are responsible for scarring and organ stiffness during fibrosis. The scar propagates mechanical signals inducing a radical transformation in myofibroblast cell state linked to an increasingly pro-fibrotic phenotype. Here, we have discovered mechanical stress from progressive scarring induces nuclear softening and de-repression of heterochromatin. The parallel loss of H3K9Me3 enables a permissive state for distinct chromatin accessibility and profibrotic gene regulation. By integrating chromatin accessibility profiles (ATAC sequencing) we provide insight into the transcription network and open chromatin landscape underlying the switch in profibrotic myofibroblast states, emphasizing mechanoadaptive pathways linked to PAK1 as key drivers. Through genetic manipulation in liver and lung fibrosis, uncoupling PAK1-dependant signaling impaired the mechanoadaptive response in vitro and dramatically improved fibrosis in vivo. Moreover, we provide human validation for mechanisms underpinning PAK1 mediated mechanotransduction in liver and lung fibrosis. Collectively, these observations provide new insight into the nuclear mechanics driving the profibrotic chromatin landscape in fibrosis, highlighting actomyosin-dependent mechanisms linked to chromatin organisation as urgently needed therapeutic targets in fibrosis. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.03.17.533127v1?rss=1 Authors: Jariwala, N., Ozols, M., Eckersley, A., Mambwe, B., Watson, R. E. B., Zeef, L., Gilmore, A., Debelle, L., Bell, M., Bradley, E. J., Doush, Y., Courage, C., Leroux, R., Peschard, O., Mondon, P., Ringenbach, C., Bernard, L., Pitois, A., Sherratt, M. J. Abstract: The exogenous application of small peptides can beneficially affect clinical skin appearance (wrinkles) and architecture (collagen and elastic fibre deposition and epidermal thickness). However, the discovery of new bioactive peptides has not been underpinned by any guiding hypothesis. As endogenous extracellular matrix (ECM)-derived peptides produced during tissue remodelling can act as molecular signals influencing cell metabolism, we hypothesised that protease cleavage site prediction could identify putative novel matrikines with beneficial activities. Here, we present an in silico to in vivo discovery pipeline, which enables the prediction and characterisation of peptide matrikines which differentially influence cellular metabolism in vitro. We use this pipeline to further characterise a combination of two novel ECM peptide mimics (GPKG and LSVD) which act in vitro to enhance the transcription of ECM organisation and cell proliferation genes and in vivo to promote epithelial and dermal remodelling. This pipeline approach can both identify new matrikines and provide insights into the mechanisms underpinning tissue homeostasis and repair. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Werken met je vrouwelijke archetypes betekent terugvallen op eeuwenoude wijsheid. Met Michelle Zeef, die haar 'Sacred Moon Journey' geeft, ga ik in gesprek over de vrouwelijke cyclus en het afstemmen op de maan.  In deze episode hoor je: - hoe Michelle de overstap maakte van communicatiemeisje naar Magische, spirituele vrouw - hoe je jezelf kunt genezen van menstruatieklachten en PMS door samen te werken met de maan - waarom het woord 'ongesteld' zijn zo snel mogelijk uit je vocabulaire verdwijnen moet - waarom het zo belangrijk is om te kiezen voor een natuurlijke vorm van anticonceptie - welke wijsheden er in je cyclus besloten liggen - hoe elk deel van je cyclus een eigen archetype kent - waarom je cyclus vaak gelijk loopt met de fasen van de maan - hoe je de fasen van de maan ook kunt benutten als je geen baarmoeder hebt, of in de overgang bent - waarom er 'sacredness' zit in het werken met de maan en nog zoveel méér...  Wil je meer weten over het werk van Michelle? Volg haar dan op instagram @michellezeef  Wil je alles weten over het werken met je vrouwelijke archetypes en hoe je deze het beste benut? Stuur me dan een DM op instagram @mariskaruissen, of via mijn site, om een GRATIS claritycall met me te boeken. In dit gesprek laat ik je zien, welke vrouwelijke archetypes jij nog onderdrukt of verstopt.Support the show (http://www.mariskaruissen.nl/boek-aan-het-stuur)

Our metric for business is value generation. The scope of Economics For Business is not determined by business size or type — we don't label firms as small, medium or large, or by the stage of their development, or by industry. We see business through the lens of entrepreneurship, defined as the intentional pursuit of new economic value. A reasonable proxy metric we can use is growth. Business growth is consequence of generating new economic value. That value is determined by customers, and a growing company is creating more customers and/or adding to its share of customer dollars spent in value exchange. The changing dimensions of business growth. The economic route to growth is changing. In today's markets, we often see speed of growth that goes beyond historical expectations. Business models can expand their reach and accelerate their performance over networks faster than ever before. An Austrian perspective on business enables entrepreneurs to perform in a high-growth environment: Austrian entrepreneurs recognize the boundaryless-ness of markets, the flexibility of capital combinations, and re-combinations to respond to the rolling flow of value learning signals from consumers, and the benefits of shedding control in order to accept complexity and emergence. Austrian entrepreneurs are well-placed to enjoy success in today's markets. Professor Mohammad Keyhani sums up the Austrian entrepreneur's advantage in the term Generativity. The generativity of a system is the capacity to produce unprompted, unanticipated change through unfiltered contributions from a large, broad, and varied audience. The concept of generativity is closely aligned with the Austrian ideas of spontaneous order and emergence. By way of an example, the concept has been applied to technologies, where the characteristics of generativity can be identified as the increase in participation as an input and the increase of innovation as an output. One of the results of this thinking has been open innovation: anyone can participate (e.g., when corporate research is not limited to a corporate R&D lab, ideas can come from anywhere outside the corporation), and more and better innovation is an outcome. One of the potential effects of generativity is to overcome knowledge constraints. Open innovation is an example: even the biggest corporation with the best minds in its employment can not possibly have a majority of good ideas. They don't even know what answers they should be looking for. With generativity, the part of the agency for the search for knowledge and entrepreneurial action is carried out by the product itself. Importantly, whereas open innovation is an organizational technique, generativity is a product characteristic. It gives the product itself some entrepreneurial agency in the Austrian sense of the word. Detaching the search process from the searcher. When we face knowledge constraints, we search for answers. But a searcher only knows to search in certain places. Generativity can separate the search from the searcher, unleashing the search process to look in places that would be blind spots for the searcher. Similarly, generative design can generate product ideas that the human designer could not. The incentives of the market can take control of the search process. The demand side (via broad, unfiltered participation) defines the problem to be solved and the supply side (via equally broad and equally unfiltered participation) creates solutions. Generative characteristics can be built-in to a product or service. 5 characteristics of generativity in products are: Leverage: the product can be put to many uses, and users can do many things with it, including those that the product designer could never anticipate. Adaptability: the product can be further modified to broaden its range of tasks even further; new code can be contributed by users, accessories can be added, and so on. Ease Of Mastery: there are no or low barriers to broad usage and broad adoption due to unusual or hard-to-acquire skills. Accessibility: the product is accessible to everyone and its usage is not limited to a specific set of users. Transferability: The advances in and changes to the technology made by some users are transferable to all users; new users can build on what previous users have contributed. Generative products are tools for entrepreneurs. Generative products are a little hard to describe or categorize. They're more like toolkits rather than specific use products. Professor Keyhani started a website to curate some of these kinds of tools / toolkits for entrepreneurs: Entrepreneur-Tools.Zeef.com/Keyhanimo Some examples he mentions: Zapier.com and Integromat.com link web apps and digital tools together via API's to assemble automated workflows. Airtable.com — flexible and powerful cloud-based relational database for regular users. No-code software development tools like Adalo.com (build your own app), Voiceflow.com (build your own voice app) and Bubble.io (anyone can be a software developer). There is a broad future growth path in generativity. Let users generate innovations; let them accumulate (new users can build on the innovations of earlier users); focus on capturing as much of the value as is appropriate for the entrepreneur-as-orchestrator. Additional Resources "How Generative Is Your Business?" (PDF): Mises.org/E4B_104_PDF "A Theory of Digital Firm-Designed Markets: Defying Knowledge Constraints with Crowds and Marketplaces" by Mohammad Keyhani, et al (on JSTOR): Mises.org/E4B_104_PDF2 Professor Keyhani's website: MohammadKeyhani.com

Our metric for business is value generation. The scope of Economics For Business is not determined by business size or type — we don't label firms as small, medium or large, or by the stage of their development, or by industry. We see business through the lens of entrepreneurship, defined as the intentional pursuit of new economic value. A reasonable proxy metric we can use is growth. Business growth is consequence of generating new economic value. That value is determined by customers, and a growing company is creating more customers and/or adding to its share of customer dollars spent in value exchange. The changing dimensions of business growth. The economic route to growth is changing. In today's markets, we often see speed of growth that goes beyond historical expectations. Business models can expand their reach and accelerate their performance over networks faster than ever before. An Austrian perspective on business enables entrepreneurs to perform in a high-growth environment: Austrian entrepreneurs recognize the boundaryless-ness of markets, the flexibility of capital combinations, and re-combinations to respond to the rolling flow of value learning signals from consumers, and the benefits of shedding control in order to accept complexity and emergence. Austrian entrepreneurs are well-placed to enjoy success in today's markets. Professor Mohammad Keyhani sums up the Austrian entrepreneur's advantage in the term Generativity. The generativity of a system is the capacity to produce unprompted, unanticipated change through unfiltered contributions from a large, broad, and varied audience. The concept of generativity is closely aligned with the Austrian ideas of spontaneous order and emergence. By way of an example, the concept has been applied to technologies, where the characteristics of generativity can be identified as the increase in participation as an input and the increase of innovation as an output. One of the results of this thinking has been open innovation: anyone can participate (e.g., when corporate research is not limited to a corporate R&D lab, ideas can come from anywhere outside the corporation), and more and better innovation is an outcome. One of the potential effects of generativity is to overcome knowledge constraints. Open innovation is an example: even the biggest corporation with the best minds in its employment can not possibly have a majority of good ideas. They don't even know what answers they should be looking for. With generativity, the part of the agency for the search for knowledge and entrepreneurial action is carried out by the product itself. Importantly, whereas open innovation is an organizational technique, generativity is a product characteristic. It gives the product itself some entrepreneurial agency in the Austrian sense of the word. Detaching the search process from the searcher. When we face knowledge constraints, we search for answers. But a searcher only knows to search in certain places. Generativity can separate the search from the searcher, unleashing the search process to look in places that would be blind spots for the searcher. Similarly, generative design can generate product ideas that the human designer could not. The incentives of the market can take control of the search process. The demand side (via broad, unfiltered participation) defines the problem to be solved and the supply side (via equally broad and equally unfiltered participation) creates solutions. Generative characteristics can be built-in to a product or service. 5 characteristics of generativity in products are: Leverage: the product can be put to many uses, and users can do many things with it, including those that the product designer could never anticipate. Adaptability: the product can be further modified to broaden its range of tasks even further; new code can be contributed by users, accessories can be added, and so on. Ease Of Mastery: there are no or low barriers to broad usage and broad adoption due to unusual or hard-to-acquire skills. Accessibility: the product is accessible to everyone and its usage is not limited to a specific set of users. Transferability: The advances in and changes to the technology made by some users are transferable to all users; new users can build on what previous users have contributed. Generative products are tools for entrepreneurs. Generative products are a little hard to describe or categorize. They're more like toolkits rather than specific use products. Professor Keyhani started a website to curate some of these kinds of tools / toolkits for entrepreneurs: Entrepreneur-Tools.Zeef.com/Keyhanimo Some examples he mentions: Zapier.com and Integromat.com link web apps and digital tools together via API's to assemble automated workflows. Airtable.com — flexible and powerful cloud-based relational database for regular users. No-code software development tools like Adalo.com (build your own app), Voiceflow.com (build your own voice app) and Bubble.io (anyone can be a software developer). There is a broad future growth path in generativity. Let users generate innovations; let them accumulate (new users can build on the innovations of earlier users); focus on capturing as much of the value as is appropriate for the entrepreneur-as-orchestrator. Additional Resources "How Generative Is Your Business?" (PDF): Mises.org/E4B_104_PDF "A Theory of Digital Firm-Designed Markets: Defying Knowledge Constraints with Crowds and Marketplaces" by Mohammad Keyhani, et al (on JSTOR): Mises.org/E4B_104_PDF2 Professor Keyhani's website: MohammadKeyhani.com

The Most Inspiring Jim Carrey Speech THE MEANING OF LIFE Maharishi University of Management (http://www.mum.edu) granted degrees to 285 students representing 54 countries. Jim Carrey gave the commencement address to Maharishi University of Management's class of 2014. The University Board of Trustees also presented Mr. Carrey with the honorary degree of Doctor of Fine Arts Honoris Causa, in recognition of his significant lifetime achievements as a world-renowned comedian and actor, artist, author and philanthropist. Captions available in the following languages (EN, FR, ES, RU, GR, SL, VN): NOTE - MAY 6, 2015: CAPTIONS ARE NOW AVAILABLE IN ENGLISH NOTE - 6 MAI 2015: SOUS-TITRES MAINTENANT DISPONIBLE EN FRANÇAIS NOTA - 01 DE JUNIO 2015: LEYENDAS SON AHORA DISPONIBLE EN ESPAÑOL Σημείωση - 3 Νοέμβρη, 2016: λεζάντες είναι τώρα διαθέσιμα σε ελληνικά GHI CHÚ - NGÀY 2, 2017: BẢNG CÂN ĐÓ Ở VIỆT NAM LinkedIn: ​https://www.linkedin.com/company/maha... FB: https://www.facebook.com/Maharishi.Un... G+: https://plus.google.com/u/0/b/1095217... ZEEF: https://maharishi-university-of-manag... TW: @MaharishiU Pinterest: https://www.pinterest.com/mumview/ Instagram: http://instagram.com/muminstagram About MUM Maharishi University of Management (MUM) in Fairfield, IA is a private university featuring Consciousness-Based℠ Education. The accredited traditional curriculum offers bachelor's, master's, and doctoral degrees in the arts, sciences, humanities, and business, but also integrates self-development programs. Innovative aspects include the Transcendental Meditation® program, one course at a time, and organic vegetarian meals. Visitors Weekends are held throughout the year. For more information, call the Admissions Office at 800-369-6480 or visit http://www.mum.edu. FAIR-USE COPYRIGHT DISCLAIMER * Copyright Disclaimer Under Section 107 of the Copyright Act 1976, allowance is made for fair use for purposes such as criticism, commenting, news reporting, teaching, scholarship, and research. Fair use is a use permitted by copyright statute that might otherwise be infringing. Non-profit, educational or personal use tips the balance in favour of fair use. 1)This video has no negative impact on the original works 2)This video is also for teaching and inspirational purposes. 3)It is not transformative in nature. Law Of Attraction Coaching does not own the rights to these images, videos and audio files. They have, in accordance with fair use, been repurposed with the intent of educating and motivate others. However, if any content owners would like their images removed, please contact us by email at innergrowth.inc@gmail.com

#70 Van Burnout Naar Het Roer Helemaal Omgooien. Geluk Is Een Keuze Met Michelle Zeef by Kim Munnecom

#70 Van Burnout Naar Het Roer Helemaal Omgooien. Geluk Is Een Keuze Met Michelle Zeef by Kim Munnecom

An airhacks.fm conversation with Arjan (@arjan_tijms) about: starting programming with Commodore 64, blog interview about zeef, "Programming in Basic" with the age of 7, Phillips P2000, Simons Basic, Assembly on Commodore 64, defaulting to C, weird main function in C, developing a database to maintain Judo progress and expenses, being a CEO of a kid organization to sell goods on free markets with other kids, SGI Indy, helping sister with recursion in Java, advertisements on websites with awin startup, OrionServer, Java Servlet Development Kit (JSDK) 1.0, Sun One Application Server, Trifork Application Server, Java EE is like operating system for business components, counting cycles for method invocations, From OrionServer to Tomcat, 3 views per server in a 2-3 node cluster, cutting libraries by moving from Tomcat to JBoss in 2 weeks, zanox.de buys awin, discussion about polyglot programming, parsing gigabytes of XML, founding Zeef.com with ten developers, monatenization challenges, starting as tech lead at Payara, JASPIC, JAAS, JACC, from form login to authenticated and authorised user, the relation between JAAS and JAAC, JAAS is about code security and code trust, in JAAC the code is trusted and the user is not trusted, JASPIC is the authentication mechanism, Java EE 8 security is the syntactic sugar around existing security specs, the simplest possible authentication with JSR-375 / Java EE 8 Security, IdentityStores vs. Realm, basic authentication and realm clarification, IdentityStore was missing in Java EE, the whole JSR-375 spec is about 12 classes, the difference between security group and roles, 1:1 role to group mapping is default in Java EE 8. Arjan's blog, Arjan on omnifaces and @omnifaces.

Mike Taylor returns to the podcast to share his top three finds from 2017 - tools that will help you work smarter and produce better visuals and presentations. Learn all about Talkbook, Canva, ribbet, Talktime, Zeef and Descript in this episode. Talkbook.co Canva.com Ribbet.com TalkTime PPT add-in: http://presentyourstory.com/talktime-free-presentation-time-management-add-powerpoint/ Zeef.com Mike Taylor on Zeef: https://zeef.com/profile/tmiket presentations.zeef.com Tracy Parish's e-learning page on Zeef: https://e-learning.zeef.com/tracy.parish Robin Good pages on Zeef https://contentcuration.zeef.com/robin.good https://content-discovery-tools.zeef.com/robin.good

In this Three Things episode of the Mindset Digital Podcast, Pete Brown recruits Jen Michaels, Mike Taylor and Matt Weiner to help catch him up on what’s happening in the digital world. From artificial intelligence to UPS dogs to Amazon Key and something called Zeef, tune into this week’s episode. Plus, we make our first Harambe joke in at least six months.

Startpagina is niet dood, sterker nog het bedrijf zet jaarlijks nog steeds 25 miljoen euro om, maar toch is net tijd voor een nieuwe variant. ZEEF heeft die ambitie. Wereldwijd, meer onderlinge concurrentie tussen beheerders en een killer affiliate team. Rick Boerebach was te gast in Top Names en legt de plannen uit.