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Discover the joys and challenges of owning a dog, and the importance of training them for real-life scenarios. Key Topics The significance of public behavior training for safety, legal compliance, and social harmony. Fundamental training principles: Basic obedience commands, consistency, and positive reinforcement. Step-by-step guide to teaching public behavior, including leash training and controlled exposure. Addressing common behavior challenges like pulling, jumping, and reactivity. The role of socialization in public behavior and tips for effective socialization. With patience and positive reinforcement, transform your dog into a well-behaved, confident companion ready to enjoy the world alongside you. Products I Use for Dog Works Radio My equipment: • SHURE SM7B Mic • Rodecaster Pro II audio production studio • Bose QuietComfort Ultra Headphones • Elgato Wave Mic Arm Pro Recommended resources: • Captivate.fm podcast hosting, distribution, analytics, and monetization • Keap CRM • Riverside.FM • Hindenburg Pro recording and editing Note: these may contain affiliate links, so I get a small percentage of any product you buy when using my link. Dog Works Radio is a podcast education show brought to you by Dog Works Radio and is hosted by Nicole Forto. If you enjoy the show, I'd love for you to leave a rating or review on your favorite podcast app! And please let your friends and other podcasters know they can listen for free on Spotify and Apple Podcasts, as well as their preferred podcast app.
Yep, now we are dealing with potential proof of electoral fraud. Nope, it wasn't the EVM. It was good old fashioned list manipulations. Why can't AI & techies make our frauds more high-tech at least? We can't do anything classy in this country. Sigh!
The Dallas Morning News food team is back after a one-month summer hiatus with their ultimate tips for making lunches easy and delicious, whether that's for back-to-school or back-to-office. Learn more about your ad choices. Visit podcastchoices.com/adchoices
The Dallas Morning News food team is back after a one-month summer hiatus with their ultimate tips for making lunches easy and delicious, whether that's for back-to-school or back-to-office. Learn more about your ad choices. Visit podcastchoices.com/adchoices
In this episode of the PFC Podcast, Dennis and Jeff delve into the complexities of anoxic brain injury, discussing its causes, recovery processes, and prevention strategies in tactical environments. They emphasize the importance of maintaining oxygen levels, effective airway management, and addressing hypotension and hypoxia. The conversation highlights the critical role of preventing secondary brain injuries and the significance of basic medical interventions in saving lives.TakeawaysAnoxic brain injury is caused by a lack of oxygen to the brain.The brain requires oxygen to function, and deprivation leads to cell death.Recovery from brain injuries can take time and various therapies.Prevention strategies in tactical environments are crucial to avoid anoxic brain injury.Monitoring oxygen levels is vital in emergency situations.Airway management decisions should be based on the patient's condition and available skills.Hypotension and hypoxia must be addressed promptly to prevent further injury.Secondary brain injuries can be prevented with proper care and monitoring.Treating pain and agitation is important to reduce intracranial pressure.Basic medical interventions can save lives in critical situations.Chapters00:00 Understanding Anoxic Brain Injury02:56 Recovery and Rehabilitation Process05:27 Prevention Strategies in Tactical Environments10:09 Monitoring and Maintaining Oxygen Levels16:48 Airway Management Decisions20:01 Addressing Hypotension and Hypoxia26:56 Preventing Secondary Brain InjuriesThank you to Delta Development Team for in part, sponsoring this podcast.deltadevteam.comFor more content, go to www.prolongedfieldcare.orgConsider supporting us: patreon.com/ProlongedFieldCareCollective or www.lobocoffeeco.com/product-page/prolonged-field-care
Go to Wix.com to start building your website today! Download the DraftKings Casino app, sign up with code BASIC, and spin your favorite slots! Get organized, refreshed, and back to routine for way less. Head to wayfair.com right now to shop all things home!
Is It Unconditional?
Welcome to the ultimate preppers guide to everything! The phrase "1 is none and 2 is one" is a fundamental principle in the prepping community, emphasizing the importance of redundancy and backup plans. In this video, we'll delve into the world of prepping and explore the essential skills, gear, and mindset required to thrive in any situation. From wilderness survival and self-defense to food storage and emergency preparedness, we'll cover it all. Whether you're a seasoned prepper or just starting out, this video is designed to provide you with actionable tips and insights to help you prepare for anything life throws your way. So, sit back, relax, and get ready to take your prepping skills to the next level! Check Out www.empshield.com Use code "badass" for $50 Off
In the first of a three-part legal series on UNCENSORED, host Marién Sarriera sits down with maritime lawyer and former officer Adria Notari to unpack the legal realities seafarers face at sea. From the limitations of the IMO, ILO, and MLC to understanding what protection crew actually have under various flag states, Adria offers straight-talking legal insight that every yachtie should hear.
In this episode we dive into some Hot Takes to see what we think about some Hot Takes.Basic, but effective.You can get in contact with us via email at themovietreepod@gmail.com or via socials.Feel free to write in with suggestions for movies you'd like to see us cover in future episodes.Also FEEL FREE TO WRITE IN WITH SUGGESTIONS FOR MOVIES YOU'D LIKE TO SEE US COVER IN FUTURE EPISODES!!We mean it. Please write in. We'll send you some free stuff.Check out our weekly videos on YouTube, TikTok and Facebook, most of them are absolute deadset bangers.If you know someone who might like this episode, or the last episode, or even any of the episodes then please hit Share on your podcast app of choice and let them know about all of the goodness that is a Movie Tree episode.As is the cliche - please like, subscribe, comment and review! Would be lovely to build on our 4 reviews we've had so far.Adios bitches. Hosted on Acast. See acast.com/privacy for more information.
This is a study and commentary of the Basic Text book within Narcotics Anonymous. We invite you to come along this journey with us. Please get your book, a highlighter, and a pen/pencil.
Basic Cryptonomics 101: Why Technical Analysis Doesn't Always Work #Crypto #Cryptocurrency #podcast #BasicCryptonomics #Bitcoin #ETH #BNB Website: https://www.CryptoTalkRadio.net Facebook: @ThisIsCTR Discord: @CryptoTalkRadio Chapters (00:00:01) - Crypto Talk Radio(00:01:41) - ETFs vs. Crypto: Is It Even Worth Holding?(00:02:09) - Bitcoin vs. Ethereum: Which Is Better?(00:04:50) - Crypto and Gold: Diversity in Your Portfolio(00:09:40) - President Trump wants to punish banks that block cryptocurrency transactions(00:11:48) - This is Why Technical Analysis is a flawed Science(00:13:12) - Liquidity Pairs(00:17:51) - The importance of sentiment in technical analysis(00:23:17) - Including Cryptocurrency in Your Portfolio
Get $100 off my brand new course, Rehabilitation of Athletic Low Back Pain, with Mike Reinold!https://mikereinold.com/athletic-low-back-evaluation-treatment-online-course/We tackle how to assess and treat different types of back pain, combining evidence-based approaches with movement-based classifications that actually work for athletes and active individuals.• Creating a systematic approach to back pain starts with understanding whether it's chronic sensitization or repeated acute flare-ups• Clinical Practice Guidelines (CPGs) often provide overwhelming lists of possible treatments without clear direction• Differentiating between extension-intolerant, flexion-intolerant, and compression-intolerant patterns guides treatment• Daily habits and postures often contribute more to pain than specific incidents• Modifying activities throughout the day helps reset pain sensitivity - "like recalibrating an alarm system"• Education about what patients do outside of PT is often more important than any specific exercise• For athletes, progression must include sport-specific movements and correcting technical flaws• Basic exercises like bird dogs and dead bugs are starting points, not complete solutions• Return to sport requires gradual progression through strength, power, and sport-specific movements• Proper bracing techniques and movement patterns are essential for long-term preventionCheck out our comprehensive back pain course at the link in the show notes - $100 off this week only!We appreciate you listening! To learn more about SHIFT, head here - https://shiftmovementscience.com/To learn about SHIFT's courses, check our website here - https://courses.shiftmovementscience.com/Also, please consider rating, reviewing, and sharing the podcast with your friends! Thanks :)Thanks for listening to The SHIFT Show! Check out SHIFT's most popular courses here! https://courses.shiftmovementscience.com/Want to join our online educational community of over 1000 gymnastics professionals and get 40+ hours of gymnastics lectures? Join The Hero Lab below!https://shiftmovementscience.com/theherolab/ Check out all our past podcast episodes here!https://shiftmovementscience.com/podcast/
75% van de marketingteams heeft geen AI-roadmap. Hoe zorg je ervoor dat jouw bedrijf niet achterblijft? In deze aflevering leer je van AI-expert Mike Kaput hoe je AI succesvol integreert in je marketingprocessen.In deze aflevering is Mike Kaput te gast, Chief Content Officer bij Marketing AI Institute. Mike is een toonaangevende expert op het gebied van AI in marketing. Hij heeft ontelbare uren besteed aan het onderzoeken, testen en implementeren van AI-tools. Met zijn diepgaande kennis helpt hij professionals wereldwijd om AI effectief in te zetten voor hun marketingstrategieën. Hij is een veelgevraagd spreker en co-host van The Artificial Intelligence Show Podcast.De belangrijkste gespreksonderwerpenWaarom 75% van de marketingteams geen AI-roadmap heeft en waarom dit problematisch is.Het concept van AI literacy: wat het is, waarom het cruciaal is en hoe je het ontwikkelt.De use case-methodologie: hoe je je werk opsplitst in taken en prioriteert welke AI kan verbeteren.Praktische tips voor het vinden van de juiste AI-tools voor specifieke taken.Mikes driestappenaanpak: bestaande technologie, algemene AI-tools en gespecialiseerde tools.Concrete voorbeelden van hoe Marketing AI Institute 75% tijd bespaart op hun podcastworkflow.Het verschil tussen AI-hype en echte praktische toepassingen.Trends richting AI-agents en wat dat betekent voor de toekomst van marketing.Change management: hoe haal je AI succesvol binnen je organisatie?Het belang van een visiegedreven benadering versus angstgedreven besluitvorming.Relevante links en bronnenMarketing AI Institute - Voor AI-educatie en -trainingSmarterX - Voor uitgebreide AI literacy-programma'sThe AI Artificial Intelligence Show-podcast - Wekelijks nieuws over AI in marketingState of Marketing AI Report 2025 - Jaarlijks onderzoek naar AI-adoptieBoek: Co-Intelligence van Ethan Mollick - Aanbevolen leesmateriaalBoek: Marketing Artificial Intelligence van Mike Kaput en Paul RoetzerOntdek de nieuwe spelregels van kopen in het digitale tijdperkWil je weten waarom traditionele sales- en marketingstrategieën niet meer werken en hoe je jouw bedrijf kunt voorbereiden op het Zero Moment of Truth-tijdperk? In de gratis online workshop "De nieuwe spelregels van kopen" van ons zusterbedrijf Buzzlytics leer je hoe de moderne klantreis is veranderd en welke strategieën wél resultaat opleveren in 2025. Meld je nu aan voor de eerstvolgende workshop en ontdek hoe je van je website je beste verkoper maakt. Ga naar form.buzzlytics.nl/de-nieuwe-spelregels en reserveer je plek voordat je concurrent het doet!
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Joining us on this episode of the Golf215 podcast is Gary and TJ from the "Basic Bogeys" podcast and YouTube channel. Gary and TJ share about their background, how they got started with their podcast and newly released episodes. Next, there recently have been discussions about PGA/USGA/R&A tournament rules, we share our opinions and some ways to update them. Listen and then head over to our message board to let us know your thoughts on rules the PGA/USGA/R&A need to updated, remove or add. Thank you for listening and your support and enjoy the episode!Music Credithttps://soundcloud.com/davidhydemusic/piano-rock-instrumental?utm_source=clipboard&utm_medium=text&utm_campaign=social_sharing
This is a study and commentary of the Basic Text book within Narcotics Anonymous. We invite you to come along this journey with us. Please get your book, a highlighter, and a pen/pencil.
20250802 Basic iPhone Class Originally Broadcasted August 2, 2025, on ACB Media 5 Whether you are new to the iPhone or have used one for years, participants joined us with their questions and problems. We try to help you use your phone more effectively and efficiently. Find out more at https://acb-community.pinecast.co
Former FBI Supervisory Special Agent Miguel Clarke joins hosts James Maude and Marc Maiffret to reflect on 25 years at the front lines of cybersecurity. From coding in BASIC on his Commodore 64 to helping uncover the digital trail behind 9/11, Miguel shares raw, behind-the-scenes stories of how real cyber investigations unfold. In this episode, you'll hear how a casual beer in Nebraska sparked a career in federal law enforcement, why psychology plays a critical role in executing search warrants, and how early cyber sleuths tracked international hackers with nothing but screen scrapes and UUencoded files. Miguel also takes us deep inside the Swedish secret police operation that caught the infamous Csaba Richter hacker, explores the rise of Eastern Europe's cybercrime economy, and breaks down the forensic breakthroughs that helped investigators piece together one of the most pivotal events in modern history. 00:00 - Introduction and Welcome 01:32 - Early Technology Interest with Commodore Computers 03:24 - System Shock and the $2,100 Computer Upgrade Nightmare 05:22 - Gaming Influence on Career Path and FBI Power Dynamics 06:42 - The Beer That Started an FBI Career 10:03 - FBI Training and Imposter Syndrome at Quantico 14:11 - Sales Skills Meet FBI Investigation Work 18:04 - Search Warrant Psychology and Family Dynamics 24:08 - The Chaba Richter International Cyber Case 27:38 - Eastern European Cybercrime Economy Theory 31:51 - Evolution from Website Defacements to Nation-State Attacks 36:24 - Digital Aspects of 9/11 Investigation 42:25 - 9/11 Digital Forensics and HTML Tag Discovery 47:56 - Transition from FBI to Private Sector 51:32 - Leadership Philosophy and Closing Thoughts
The enemy comes into our life like the slow and steady builing of a flood. ******* By the way, if you haven't bought a copy of my new book yet, check it out here: https://www.amazon.com/Dreams-Visions-Stories-Faith-Pastor/dp/161493536X
Earn points on rent and around your neighborhood, wherever you call home, by going to joinbilt.com/basic Go to https://kachava.com and use code BASIC for 15% off your next order!
The post Polygamy Deny-ers and Getting Back to our Basic Ingredients AoN 955 appeared first on The Cultural Hall Podcast.
We have to battle against the flood that the enemy tries to pour into our life. ******* By the way, if you haven't bought a copy of my new book yet, check it out here: https://www.amazon.com/Dreams-Visions-Stories-Faith-Pastor/dp/161493536X
John Shea of the San Francisco Standard joins Papa & Silver to discuss the Giants' approach to the trade deadline and why they have struggled so poorly with basic fundamentals latelySee omnystudio.com/listener for privacy information.
Ministered by Pastor Jonathan Skiles at New Life Church of La Habra in La Habra, CA. God bless you and thank you for listening! If you would like to learn more about our ministry or give an offering, please visit our website at www.nlclahabra.com Visit us on Instagram: @nlclahabra Our Address: New Life Church of La Habra 740 E. Lambert Rd. Unit E La Habra, CA 90631
John Shea of the San Francisco Standard joins Papa & Silver to discuss the Giants' approach to the trade deadline and why they have struggled so poorly with basic fundamentals latelySee omnystudio.com/listener for privacy information.
The Bible talks about the enemy coming in like a flood. ******* By the way, if you haven't bought a copy of my new book yet, check it out here: https://www.amazon.com/Dreams-Visions-Stories-Faith-Pastor/dp/161493536X
Even though it's the toughest part of the season to care about, we are finding some immortal value. On the show:AccountabilityEels v StormWarriors v DolphinsBroncos v RabbitohsTitans v PanthersDragons v RaidersSea Eagles v RoostersTigers v BulldogsSharks v CowboysUnit Scooper & Hot SeatWhatever you bet on, Take it to the Neds Level. Visit: https://www.neds.com.au/Prices subject to change. What's gambling really costing you?. Set a deposit limit.Join the Neds About Even Group: www.neds.com.au/hosted-group/DRIBBLER Eligibility requirements apply. T&Cs apply and available on website. Follow us on insta @abouteven_ Hosted on Acast. See acast.com/privacy for more information.
There's a difference between a flood and a flash flood. ******* By the way, if you haven't bought a copy of my new book yet, check it out here: https://www.amazon.com/Dreams-Visions-Stories-Faith-Pastor/dp/161493536X
Ever wondered why a molecule as simple as hydrogen could influence everything from Parkinson's to metabolic syndrome? We explored how molecular hydrogen selectively targets only the most harmful free radicals while leaving beneficial ones alone, making it fundamentally different from every other antioxidant supplement gathering dust in your cabinet.The six-month metabolic syndrome study particularly caught my attention: participants drinking hydrogen water saw improvements in glucose levels, HbA1c, inflammation markers, and even lost weight – with no diet changes or exercise requirements.Tyler breaks down why those expensive alkaline water machines aren't doing what you think (spoiler: it's not about pH), why hydrogen inhalation requires serious safety considerations, and exactly how to dose hydrogen water for maximum benefit.And on top of all this, we tackle why this primordial molecule – literally present since the beginning of the universe – seems almost designed to work with human biology, and why megadoses of vitamins C and E can actually harm exercise performance while hydrogen acts as a fine-tuning modulator.Timestamps:0:00 Hydrogen's effects on major diseases2:45 Six-month metabolic syndrome study results5:15 Hydrogen only targets toxic radicals6:08 Divine properties of hydrogen molecule10:12 Basic chemistry of oxidation and reduction15:30 Dangers of excessive antioxidants23:45 How hydrogen modulates antioxidant systems47:20 Hydrogen production in your gut56:30 Inhaled vs drinking hydrogen water61:15 Explosive dangers of hydrogen inhalation71:30 Therapeutic dosing for hydrogen water85:45 Debunking alkaline and structured water94:30 Tyler's elite athletic performance secretsDisclaimer:Dr. Paul Saladino received his medical degree from the University of Arizona Medical School. His use of "doctor" or "Dr." in relation to himself solely refers to that degree. Dr. Saladino is a licensed physician in California, but he no longer practices in any state and does not see patients so he can focus on educating people full time.This video is for general informational purposes only. It should not be used to self-diagnose and it is not a substitute for a medical exam, cure, treatment, diagnosis, or prescription. It does not create a doctor-patient relationship between Dr. Saladino and you. Always consult your physician before making any health decisions.
Welcome to the Civilian Medical Podcast episode 078 Opening Brief scenario: "You're 3miles from the nearest road when your buddy collapses…" Purpose: Why every outdoorsman should be ready for medical emergencies Understanding the Off-Grid Medical Reality EMS might be 30+ minutes to several hours away No cell service, limited supplies Weather concerns Importance of self-reliance and scene control Right gear, right training Medical Emergencies Off-Grid Walk through common emergencies using simple terms and practical examples: Bleeding & Trauma (gunshots, falls, knife injuries) Broken Bones & Sprains (tree stand falls, uneven ground) Hypothermia & Heat Stroke (seasonal threats) Chest Pain / Cardiac Arrest Allergic Reactions (bee stings, food, meds) First-Line Response Principles What to do in the first 10 minutes: Scene safety and patient assessment (basic AVPU, ABCs) "MARCH" acronym in trauma care stands for Massive Hemorrhage, Airway, Respirations, Circulation, and Hypothermia/Head injuryWhen and how to move someone vs. stay put Basic splinting) once life threats have been addressed What to Carry: The Essential Off-Grid First Aid Kit Tourniquet (TQ) — and why it's a must-have Hemostatic gauze CPR mask or face shield Epinephrine auto-injector (if allergic) Chest seals (for hunters) Emergency blanket, SAM splint, gloves, duct tape, fire starter How to improvise with what you already have You can build your own or start with a base kit and customize: Skinny Medic Essentials Kit – includes trauma gear, NPA, gloves, and more I-ROK Rugged Outdoor Kit – waterproof, includes burn gel, CPR mask, antiseptics 1 Condor Small First Aid Kit – compact, includes basics for everyday use Emergency Communication & Rescue Tips Satellite phones messengers Leave a trip plan: when and where you're going, when you'll return Training Resources & Next Steps Wilderness First Aid (WFA) vs. Wilderness First Responder (WFR) NOLS classes Encourage listeners to practice basic skills like applying a tourniquet Plan for August Meteorologist Ultimate Summer First Aid Kit Checklist Trauma & Bleeding Control CAT or SOF-T Tourniquet – for life-threatening limb bleeds QuikClot Combat Gauze – hemostatic agent for deep wounds Israeli or OLAES Pressure Bandage – versatile for bleeding and splinting Chest Seals (HyFin Vent) – for open chest injuries (e.g., punctures) Airway & Breathing Nasopharyngeal Airway (NPA) – maintain airway in unconscious individuals CPR Face Shield or Pocket Mask – safe rescue breathing Burns, Bites & Environmental Burn Gel or Burn Dressings – for sunburns, campfire burns, etc. Sting Relief Wipes or Bite Treatment Packets – for insect bites and stings Electrolyte Tablets – prevent dehydration in hot weather Emergency Mylar Blanket – for shock or sudden weather changes Basic Wound Care Adhesive Bandages (variety pack) – for cuts, scrapes, blisters Sterile Gauze Pads & Rolls – for wound dressing and cleaning Antiseptic Wipes & Antibiotic Ointment – infection prevention Medical Tape – secure dressings Tweezers – remove splinters or ticks Tools & PPE Trauma Shears – cut clothing or gear Nitrile Gloves – protect both patient and responder Triangle Bandage – sling or wrap Elastic Bandage (ACE wrap) – for sprains or compression Medications (OTC) Ibuprofen or Acetaminophen – pain and inflammation Diphenhydramine (Benadryl) – allergic reactions Anti-diarrheal (Loperamide) – travel-related stomach issues Recommended Kits to Start With You can build your own or start with a base kit and customize: Skinny Medic Essentials Kit – includes trauma gear, NPA, gloves, and more
I always hate to hear about tragedies where life is lost. ******* By the way, if you haven't bought a copy of my new book yet, check it out here: https://www.amazon.com/Dreams-Visions-Stories-Faith-Pastor/dp/161493536X
In this JCO Article Insights episode, Michael Hughes summarizes “International Myeloma Society and International Myeloma Working Group Consensus Recommendations on the Definition of High-Risk Multiple Myeloma" by Avet-Loiseau et al. published on June 09, 2025 along with an interview with author Dr Nikhil C. Munshi, MD. TRANSCRIPT Michael Hughes: Welcome to this episode of JCO Article Insights. This is Michael Hughes, JCO's editorial fellow. Today I am interviewing Dr. Nikhil Munshi on the “International Myeloma Society and International Myeloma Working Group Consensus Recommendations on the Definition of High-Risk Multiple Myeloma” by Avet-Loiseau et al. At the time of this recording, our guest has disclosures that will be linked in the transcript. While some patients with multiple myeloma live for decades after treatment, others exhibit refractory or rapidly relapsing disease irrespective of treatment administered. We term this “high-risk myeloma.” Multiple risk stratification systems have been created, starting with the Durie-Salmon system in 1975 and evolving with the advent of novel therapeutics and novel treatment approaches. In 2015, the Revised International Staging System (R-ISS) was introduced, which incorporated novel clinical and cytogenetic markers and remained, until recently, a mainstay of risk stratification in newly diagnosed disease. Myeloma as a field has, just in the past few years, though, undergone explosive changes. In particular, we have seen groundbreaking advances not only in treatments - the introduction of anti-CD38 agents and the advent of cellular and bispecific therapies - but also in diagnostic technology and our understanding of the genetic lesions in myeloma. This has led to the proliferation of numerous trials employing different definitions of high-risk myeloma, a burgeoning problem for patients and providers alike, and has prompted attempts to consolidate definitions and terminology. Regarding cytogenetic lesions, at least, Kaiser et al's federated meta-analysis of 24 therapeutic trials, published here in the JCO in February of 2025 and recently podcasted in an interview with associate editor Dr. Suzanne Lentzsch, posited a new cytogenetic classification system to realize a shared platform upon which we might contextualize those trial results. This article we have here by Dr. Avet-Loiseau, Dr. Munshi, and colleagues, published online in early June of this year and hot off the presses, is the definitive joint statement from the International Myeloma Society (IMS) and the International Myeloma Working Group (IMWG). What is high-risk multiple myeloma for the modern era? The IMS and IMWG Genomics Workshop was held in July 2023 and was attended by international myeloma experts, collaborating to reach consensus based on large volumes of data presented and shared. The datasets included cohorts from the Intergroupe Francophone du Myélome (IFM); the HARMONY project, comprised of multiple European academic trials; the FORTE study, findings from which solidified KRd as a viable induction regimen; the Grupo Español de Mieloma Múltiple (GEM) and the PETHEMA Foundation; the German-Speaking Myeloma Multicenter Group (GMMG); the UK-based Myeloma XI, findings from which confirmed the concept of lenalidomide maintenance; Emory 1000, a large, real-world dataset from Emory University in Atlanta; the Multiple Myeloma Research Foundation Clinical Outcomes in Multiple Myeloma to Personal Assessment of Genetic Profile (CoMMpass) dataset; and some newly diagnosed myeloma cohorts from the Mayo Clinic. Data were not pooled for analyses and were assessed individually - that is to say, with clear a priori understanding of whence the data had been gathered and for what original purposes. Consensus on topics was developed based on the preponderance of data across studies and cohorts. In terms of results, substantial revisions were made to the genomic staging of high-risk multiple myeloma, and these can be sorted into three major categories: A) alterations to the tumor suppressor gene TP53; B) translocations involving chromosome 14: t(14;16) (c-MAF overexpression), t(14;20) (MAFB overexpression), and t(4;14) (NSD2 overexpression); and C) chromosome 1 abnormalities: deletions of 1p or additional copies of 1q. In terms of category A, TP53 alterations: Deletion of 17p is present in up to 10% of patients at diagnosis and is enriched in relapsed or refractory disease. This is well-documented as a high-risk feature, but the proportion of the myeloma cells with deletion 17p actually impacts prognosis. GEM and HARMONY data analyses confirmed the use of 20% clonal cell fraction as the optimal threshold value for high-risk disease. That is to say, there must be the deletion of 17p in at least 20% of the myeloma cells on a FISH-analysis of a CD138-enriched bone marrow sample to qualify as high-risk disease. TP53 mutations can also occur. Inactivating mutations appear to have deleterious effects similar to chromosomal losses, and the biallelic loss of TP53, however it occurs, portends particularly poor prognosis. This effect is seen across Myeloma XI, CoMMpass, and IFM cohorts. Biallelic loss is rare, it appears to occur in only about 5% of patients, but next-generation sequencing is nevertheless recommended in all myeloma patients. Category B, chromosome 14 translocations: Translocation t(14;16) occurs in about 2% to 3% of patients with newly diagnosed disease. In the available data, primarily real-world IFM data, t(14;16) almost always occurs with chromosome 1 abnormalities. Translocation t(4;14) occurs in about 10% to 12% of newly diagnosed disease, but only patients with specific NSD2 alterations are, in fact, at risk of worse prognosis, which clinically appears to be about one in every three of those patients. And so together, the CoMMpass and Myeloma XI data suggest that translocation t(4;14) only in combination with deletion 1p or gain or amplification of 1q correlates with worse prognosis. Translocation t(14;20) occurs in only 2% of newly diagnosed disease. Similar to translocation t(4;14), it doesn't appear to have an effect on prognosis, except if the translocation co-occurs with chromosome 1 lesions, in which case patients do fare worse. Overall, these three translocations - t(14;16), t(4;14), and t(14;20) - should be considered high-risk only if chromosome 1 aberrations are also present. In terms of those chromosome 1 aberrations, category C, first deletions of 1p: Occurring in about 13% to 15% of newly diagnosed disease, deletion 1p eliminates critical cell checkpoints and normal apoptotic signaling. In the IFM and CoMMpass dataset analyses, biallelic deletion of 1p and monoallelic deletion of 1p co-occurring with additional copies of 1q denote high-risk. In terms of the other aberration in chromosome 1 possible in myeloma, gain or amplification of 1q: This occurs in up to 35% to 37% of newly diagnosed disease. It upregulates CKS1B, which is a cyclin-dependent kinase, and ANP32E, a histone acetyltransferase inhibitor. GEM and IFM data suggest that gain or amplification of 1q - there was no clear survival detriment to amplification - is best considered as a high-risk feature only in combination with the other risk factors as above. Now, in terms of any other criteria for high-risk disease, there remains one other item, and that has to do with tumor burden. There has been a consensus shift, really, in both the IMS and IMWG to attempt to develop a definition of high-risk disease which is based on biologic features rather than empirically observed and potentially temporally dynamic features, such as lactate dehydrogenase. Beta-2 microglobulin remains an independent high-risk indicator, but care must be taken when measuring it, as renal dysfunction can artificially inflate peripheral titers. The consensus conclusion was that a beta-2 microglobulin of at least 5.5 without renal failure should be considered high-risk but should not preclude detailed genomic profiling. So, in conclusion, the novel 2025 IMS-IMWG risk stratification system for myeloma is binary. It's either high-risk disease or standard-risk disease. It's got four criteria. Number one, deletion 17p and/or a TP53 mutation. Clonal cell fraction cut-off, remember, is 20%. Or number two, an IGH translocation - t(4;14), t(14;16), t(14;20) - with 1q gain and/or deletion of 1p. Or a monoallelic deletion of 1p with 1q additional copies or a biallelic deletion of 1p. Or a beta-2 microglobulin of at least 5.5 only when the creatinine is normal. This is a field-defining work that draws on analyses from across the world to put forward a dominant definition of high-risk disease and introduces a new era of biologically informed risk assessment in myeloma. Now, how does this change our clinical approach? FISH must be performed on CD138-enriched samples and should be performed for all patients. Next-generation sequencing should also be performed on all patients. Trials will hopefully now begin to include this novel definition of high-risk multiple myeloma. It does remain to be seen how data from novel therapeutic trials, if stratified according to this novel definition, will be interpreted. Will we find that therapies being evaluated at present have differential effects on myelomas with different genetic lesions? Other unanswered questions also exist. How do we go about integrating this into academic and then community clinical practice? How do we devise public health interventions for low-resource settings? To discuss this piece further, we welcome the esteemed Dr. Nikhil Munshi to the podcast. Dr. Munshi is a world-renowned leader in multiple myeloma and the corresponding author on this paper. As Professor of Medicine at Harvard Medical School, Director of the Multiple Myeloma Effector Cell Therapy Unit, and Director of Basic and Correlative Science at the Jerome Lipper Multiple Myeloma Center of the Dana-Farber Cancer Institute, he has presided over critical discoveries in the field. Thank you for joining us, Dr. Munshi. Dr. Nikhil Munshi: Oh, it's my pleasure being here, Michael, to discuss this interesting and important publication. Michael Hughes: I had a few questions for you. So number one, this is a comprehensive, shall we say, monumental and wide-ranging definition for high-risk myeloma. How do you hope this will influence or impact the ways we discuss myeloma with patients in the exam room? And how do we make some of these components recommended, in particular next-generation sequencing, feasible in lower-resource settings? Dr. Nikhil Munshi: So those are two very important questions. Let's start with the first: How do we utilize this in our day-to-day patient care setting? So, as you know well, we have always tried to identify those patients who do not do so well with the current existing treatment. And for the last 30 years, what constitutes a myeloma of higher risk has continued to change with improvement in our treatment. The current definition basically centers around a quarter of the patients whose PFS is less than 2 to 3 years. And those would require some more involved therapeutic management. So that was a starting point of defining patients and the features. As we developed this consensus amongst ourselves - and it's titled as “International Myeloma Society, International Myeloma Working Group Consensus Recommendation” - this IMS-IMWG type of recommendation we have done for many years, improvising in various areas of myeloma care. Now, here, we looked at the data that was existing all across the globe, utilizing newer treatment and trying to identify that with these four-drug regimens, with transplant and some of the immunotherapy, which group of patients do not do as well. And this is where this current algorithm comes up. So before I answer your question straight, “How do we use it?” I might like to just suggest, “What are those features that we have identified?” There are four features which constitute high-risk disease in the newer definition. Those with deletion 17p with 20% clonality and/or TP53 mutation. Number two, patients with one of the translocations - t(4;14), t(14;16), or t(14;20) - co-occurring with 1q amplification or deletion 1p32. And that's a change. Previously, just the translocation was considered high-risk. Now we need a co-occurrence for it to be called high-risk. The third group is patients having biallelic deletion 1p32 or monoallelic deletion 1p32 along with 1q amplification. And finally, patients with high beta-2 microglobulin, more than or equal to 5.5 mg/dL, with normal creatinine less than 1.2 mg/dL. And the question, “How do we use this?” There are multiple areas where we incorporate high-risk features in our treatment algorithm. One of the first areas is where we would consider the induction regimen. If a patient has a high-risk disease, we would definitely consider a four-drug regimen rather than a three-drug regimen, although we are beginning to incorporate four-drug for all groups. That's one important thing. Number two, those are the patients where we do consider consolidation with transplant or maybe in the new world, considering some of the immunotherapeutic consolidation more early or more aggressively. Number three, these are the patients who get a little bit more maintenance therapy. So normally, lenalidomide might end up being our standard maintenance regimen. In patients who have high-risk disease, we incorporate either addition of daratumumab or the anti-CD38 targeting antibody and/or addition of proteasome inhibitor, either bortezomib or carfilzomib. So you would have multi-drug maintenance therapy in these patients. And in high-risk patients, we follow them with maintenance longer periods of time. One very critically important point to keep in mind is that to get the better outcome in high-risk disease, we must try to get them into MRD negativity because there is clear data that patients who do achieve MRD negativity, despite having high-risk disease, have a much superior outcome. They become near to standard-risk disease. And so, in high-risk patients, I would try to do whatever various options I have to try and get them into MRD-negative status. And when these patients relapse, we do not wait for the classic progression criteria to be met before we intervene. We would propose and suggest that we intervene earlier before the disease really blasts off. And so there are a number of areas in our setting where this high-risk definition will help us intervene appropriately and also with appropriate aggressiveness to achieve better outcome, to make this similar to standard-risk disease. Michael Hughes: Thank you, Dr. Munshi. And thoughts on how to really integrate this not only into academic centers but also lower-resource settings? Dr. Nikhil Munshi: So that's a very important question, Michael. And when we were developing this consensus, we were very cognizant of that fact. So wherever available, I think we are recommending that over a period of next 2, 3, 5 years, we should begin to switch over to sequencing-based methods because two components of this definition, one is TP53 mutation, which we cannot do without sequencing, and also reliably detecting deletion 1p requires sequencing-based method. So in the low-resource countries - and there are many in this world, and also even in our own country, patients may not be able to afford it - the older method with FISH or similar such technology, which is more affordable, is also acceptable for current time. They may miss a very small number of patients, maybe 2% to 3%, where these finer changes are not picked up, but a majority of this would be captured by them. So the current practice might still be applicable with some limitation in those patient populations, and that's what we would recommend. What is happening, fortunately, is that actually sequencing-based method is becoming cheaper. And in many centers, it is cheaper to do the sequencing rather than to do the FISH analysis. And so my hope is that even in low-resource centers, sequencing might be more economical in the end. It's, I think, the access to technology, which is a little bit limited currently, but it's hopefully becoming available soon. Michael Hughes: Thank you, Dr. Munshi. And staying for a minute and looking at the multiple myeloma subsets which might be missed by this really still very broad-ranging high-risk definition, at least by prior risk stratification systems, right, there is this group of patients who have standard-risk cytogenetics by R-ISS or R2-ISS, but they have primary refractory disease or they relapse early. We call these, as you are well aware, functionally high-risk disease. What proportion of previously FHR, functionally high-risk, myeloma patients do you expect to be captured by this novel definition? Dr. Nikhil Munshi: So I think the newer definition - and we can look at it both ways, but the newer definition should capture most of the functionally high-risk definition. To put it differently, Michael, there are patients who we know are, as you mentioned, functionally high-risk. Those are the patients who might have plasma cell leukemia, those who might have extramedullary disease, those who might not respond to our four-drug induction. If you don't respond to the four-drug induction, almost by definition, they are high-risk. However, a majority of them have one of the abnormalities that we are describing here. There would be a very small proportion which may not have. And if they do not have, we know one of the important components of this definition here is also that the genome, we know, keeps on evolving. So there may be a very small clone with the high-risk feature which was not obvious in the beginning. Following treatments or following relapse, that clone predominates, and now the patient's disease becomes high-risk. So the definition would incorporate or would capture these functional high-risk patients, but as you said, in countries where resources are not available, using this functional high-risk would also be helpful and advantageous. Sometimes LDH ends up being a high-risk. In our studies, LDH has not come out to be high-risk anymore because the features we are describing captures most of those patients, but those alternatives, older, can still be considered if other newer techniques are not available. Michael Hughes: Got you. And in terms of these older definitions, yes, that incorporate tumor burden, these empirical observations about how myeloma presents, do you foresee any additional tumor burden indicators being added to future definitions of high-risk disease? Or do you instead see this particular definition as a major waypoint on the journey towards a fully biologically grounded definition of high-risk disease? Dr. Nikhil Munshi: I think your second part is what is going to happen. I think the tumor burden-related definition is being now replaced by the biological or genomic-based definition. And I think at some point, it will be quite fully replaced. One component not here, and it is because one thing, we don't have enough data; number two, we don't know how it will pan out, is also the influence of the microenvironment on the risk definition. For example, the immune system, the immune function, etc. But not enough data exists to suggest how it would change the current definition. So in future, would a definition be totally genomic or it could be more integrative? And my personal guess is that it would be more integrative and that some immune features might come into the picture, especially now that we are using immune-based therapy as a very important component of treatment - CAR T-cells, bispecific, and antibody-based treatments. What role the immune system plays in either supporting tumor or what role suppression of the anti-tumor immunity plays? They all will be important how patient outcomes end up being, and which in turn could translate into how patient's risk stratification might happen. So I think the older tumor burden-related definitions probably will become things of the past. What we have currently proposed and consensus developed is the new path forward, and over time, some microenvironmental influences, if defined and found to be important, may get some more incorporation if it compares favorably with the genomic features. Michael Hughes: Thank you, Dr. Munshi for that enlightening response. To conclude the podcast, I'd like to look to the future and to the immediate future, what are the next steps for high-risk disease definition between now and discussing an integrated genomic-microenvironment-based definition? Will we see attempts to refine? Will we see a multi-level system, things like this? Dr. Nikhil Munshi: Yeah, so I think the current definition will be here to stay for the next 10 years or so. I think this has been developed using a large amount of data, so we do believe that this will remain fine. It has been validated now within the last six months by a few of the other studies. So there won't be a quick change. But we will try to, all of us will try to innovate. And as you very rightly bring up, the areas of research would include looking at the expression or transcriptomic component. Does that matter? And we do believe a small number of patients will have transcriptomic changes, not looked at the DNA changes, and may play a role. There are newer components, so long non-coding RNA, for example, is going to be an important component to look at, how it impacts the disease outcome, etc. There are also some of the proteomic-related changes which may become important in our studies. And then as we discussed, microenvironment and immunological changes. So these are the future areas of ongoing research where we all should collect data, and then in the next 5 to 10 years, we'll have another group meeting to see has anything changed or any of the features have become more important. Most of the time, some of the older features are lost because they are not as critically high-risk, and the newer features come in. And so the historical background for just one second, there was a time when chromosome 13 was considered a high-risk disease. We now don't even mention it because it's not high-risk. The newer treatments have improved the outcome. t(4;14) used to be a high-risk disease. Now by itself today, in this definition by itself is not; it needs to be with something else. And so I think this is a great sign of progress. As we improve the treatment and outcomes, some of the features will become less important, new features will come up, and we'll need to keep on evolving with time and with technology and make it better for patients. Michael Hughes: Thank you so much, Dr. Munshi, for your wisdom, for your sagacity, for your historical perspective as well. Thank you for listening to JCO Article Insights. Please come back for more interviews and article summaries. And be sure to leave us a rating and review so others can find our show. For more podcasts and episodes from ASCO, please visit asco.org/podcasts. The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement.
The New World Order, Agenda 2030, Agenda 2050, The Great Reset and Rise of The 4IR
History, Philosophy, Theology and Metaphysics : Ceremonial Magic and Sorcery (Philosophical Exposé) Basic Knowledge Series 1 (Manly P Hall)To support the [Show] and its [Research] with Donations, please send all funds and gifts to :$aigner2019 (cashapp) or https://www.paypal.me/Aigner2019 or Zelle (1-617-821-3168). Shalom Aleikhem!
This week's guest is Rob Smith: the mad‑scientist of the retro scene. Rob takes us on a tour of his wild inventions—from a disco‑themed floppy‑disk cleaning workstation that actually plays tunes, to a full‑scale whack‑a‑mole game controlled by an Amiga via Arduino and AMOS, and his glowing levitating Boing Ball built with magnets and LEDs. He also talks about the Retro Directory, disc backup stations, and his journey from VIC 20 BASIC to making modern retro PD titles. Rob Smith's website: https://robsmithdev.co.uk/ Contents: 00:00 - The Week's Retro News Stories 47:48 - Dave Isherwood Interview Please visit our amazing sponsors and help to support the show: Sheffield Gaming Market: https://www.sheffieldgamingmarket.com/ Bitmap Books - https://www.bitmapbooks.com Take your business to the next level today and enjoy 3 months of Shopify for £1/month: https://shopify.co.uk/retrohour We need your help to ensure the future of the podcast, if you'd like to help us with running costs, equipment and hosting, please consider supporting us on Patreon: https://theretrohour.com/support/ https://www.patreon.com/retrohour Get your Retro Hour merchandise: https://bit.ly/33OWBKd Join our Discord channel: https://discord.gg/GQw8qp8 Website: http://theretrohour.com Facebook: https://www.facebook.com/theretrohour/ X: https://twitter.com/retrohouruk Instagram: https://www.instagram.com/retrohouruk/ Bluesky: https://bsky.app/profile/theretrohour.com Twitch: https://www.twitch.tv/theretrohour Show notes Atari Classics in Volkswagen Vehicles: https://tinyurl.com/wfner8j2 Paprium Flash Cart Release: https://tinyurl.com/2ucerftm Metro's Top 20 Amiga Games: https://tinyurl.com/ftz5y86h Grant Sinclair Gamercard: https://tinyurl.com/nzc9uuem Atari x Pac-Man Collection – Limited Edition 2600+: https://tinyurl.com/47ar835w Atari 50 Namco DLC: https://tinyurl.com/bd8xczzs Modern SNES Handheld in Development: https://tinyurl.com/45c8u3jn
In this wide-ranging episode, Javito and Welly F. dive headfirst into what happened to good ol' human decency. From elevator button etiquette and gym phone returns to Spider-Verse karma theories and fast fashion reality checks, they peel back the layers of why people just… aren't polite anymore. Throw in hot takes on LeBron's NBA exit plan, the definition of true success (spoiler: it's peace), and why everybody's trying to skip the grind and start in a Ferrari...and you've got yourself a masterclass in social commentary with zero boundaries.
Fifty years ago, Bill Gates and Paul Allen's agreement with MITS for a BASIC interpreter for the Altair 8800 microcomputer marked the founding of Microsoft, profoundly influencing the world of personal computing. This collaboration transformed technology, paving the way for PCs, Microsoft's global dominance, and the eventual rise of Linux and modern computing ecosystems. -Thinking … Continue reading 50 Years of Microsoft: How the Altair 8800 and BASIC Revolutionized Computing #1835 → The post 50 Years of Microsoft: How the Altair 8800 and BASIC Revolutionized Computing #1835 appeared first on Geek News Central.
Two siblings end up in a shared dream and explore it according to their priorities: eating food and making friends. Genre: Fairy Tale, Fantasy Excerpt: As Astra kept staring at the sign, the characters began to shift into ones she could read. She grinned and started reading aloud. “Dream Sector Alpha. Basic fantasies. Opening gifts. Eating rocky road brownies—wait, I don't like rocky road brownies.” “I do!” Fen said. “Dream Sector Beta…Zeta…Theta. Hey, I know this. This is the Greek alphabet.” What story or stories am I revisiting in this episode? Each Season 8 episode is a standalone story, but it's connected to or inspired by a previous story through a character, a place, an object, a concept, a continuation of events (ahem, sequel), and so on. This story revisits “The Mystery of Mrs. Highweather,” in which a new father, seeking stories for his baby daughter, stumbles across a series of books he used to love in his childhood about the caretaker of two adventurous kids. MY FIRST BOOK (yay)Ever wonder how I've gotten all these hundreds of stories written? I have a method. And I talk all about it in my book called Fictioneer's Field Guide: A Game Plan for Writing Short Stories. It's now available as an eBook, paperback, and hardcover. The book title takes you straight to the book on Amazon. Or you can visit my Store page: STORYFEATHER STORE The Store page also has sign-up forms for my two email newsletters: Storyfeather Gazette (if you'd like to keep up with the fiction I create) Fictioneer's Field Guide (if you'd like writing tips and guidance from me) Choose what you want. (Either way, you're choosing high jinks.) MERCH!Interested in merch, like mugs and notebooks, featuring my artwork? Please visit my Store page for updated info on where you can buy: STORYFEATHER STORE CREDITSStory: “Two Tickets to Dream Sector Disigma” Copyright © 2021 by Nila L. Patel Narration, Episode Art, Editing, and Production: Nila L. Patel Music: “Packed lunch” by TRG Banks (Intro) “The silver bus” by TRG Banks (Outro) “Abstract Vision #5” by ANDREW SITKOV (Outro) Music by TRG BANKS “Through the gravitational field” “The silver bus” “Packed lunch” “First stop” “Horse ride 4” “Cigar” Music by ANDREW SITKOV* “Casual Theme #2” “Casual Theme #4” “Knight Power” “Secrets of Kingdom” “Journey into Fog” “Battle March” “Protection of Kingdom” “Knight Rising” *All these tracks are part of a music and sound effects bundles I purchased from Humble Bundle and sourced from GameDev Market. Music by Andrew Sitkov is licensed from GameDev Market Music by TRG Banks is licensed under CC0 1.0 Universal Sound effects from AudioJungle, and GameDevMarket, and Soundly (through Hindenburg) Changes made to the musical tracks? Just cropping of some to align with my narration. Find more music by Andrew Sitkov at gamedevmarket.net Find more music by TRG Banks at freemusicarchive.org/music/TRG_Banks Find more stories by Nila at storyfeather.com Episode Art Description: Digital drawing of a stream cutting through a grassy meadow. Foreground left corner displays glowing curling stems. A ladybug is perched on one of the stems. Bottom middle edge, a piece of paper floats in the water. To the ladybug's left, a wooden sign juts up from the grass. In the upper third of the image, forests are visible through purple haze, and mountains even further back. The sky glows with sunlight. The rectangular image is made square with top and bottom borders that repeat and continue the top and bottom of the image. Watermark of “Storyfeather” along the edge of the river at center right.
Continuing our study in Genesis chapter 20. ******* By the way, if you haven't bought a copy of my new book yet, check it out here: https://www.amazon.com/Dreams-Visions-Stories-Faith-Pastor/dp/161493536X
CAT3RAC2175-26031987-12062024prescience (computing) -/- equilibriumIncident Elements:· psychological manipulation· abuse· imprisonment· implied sexual coersionNote: This episode features a significant amount of German language. Translation is available in the transcript.Transcripts available at https://rustyquill.com/transcripts/the-magnus-protocol/You can find a complete list of our Kickstarter backers https://rustyquill.com/the-magnus-protocol-supporter-wall/Created by Jonathan Sims and Alexander J Newall Directed by Alexander J NewallWritten by Alexander J NewallScript Edited with additional material by Jonathan SimsExecutive Producers April Sumner, Alexander J Newall, Jonathan Sims, Dani McDonough, Linn Ci, and Samantha F.G. Hamilton Associate Producers Jordan L. Hawk, Taylor Michaels, Nicole Perlman, Cetius d'Raven, and Megan Nice Produced by April SumnerFeaturing (in order of appearance) Billie Hindle as Alice DyerRobert Vernon as Heinrich UnheilmichClaudia Woodhouse as Klara VogelAnusia Battersby as Gwen BouchardSarah Lambie as Lena KelleyDialogue Editor – Lowri Ann DaviesSound Designer – Tessa VroomMastering Editor - Catherine RinellaMusic by Sam Jones (orchestral mix by Jake Jackson) Art by April Sumner SFX from Soundly and Additional SFX Voices by Sebastian Hutter and Katarina Ebneter Freesound: TSP-Talk, dbspin, kiefspoon, kyles, rodinvoil, vancer, Yuval, toefur, blaukreuz, delaxgray, LiMati, DeqstersLab, Voltrod, ahill86, fthrll, giddster, Gilgiuliani, waweee, SpliceSound, Kinoton, sidequestingCheck out our merchandise available at https://www.redbubble.com/people/RustyQuill/shop and https://www.teepublic.com/stores/rusty-quillSupport Rusty Quill by purchasing from our Affiliates;DriveThruRPG – DriveThruRPG.comJoin our community:WEBSITE: rustyquill.comFACEBOOK: facebook.com/therustyquillX: @therustyquillEMAIL: mail@rustyquill.com The Magnus Protocol is a derivative product of the Magnus Archives, created by Rusty Quill Ltd. and licensed under a Creative Commons Attribution Non-Commercial Share alike 4.0 International Licence. Hosted on Acast. See acast.com/privacy for more information.
Shop outdoor furniture, grills, lawn games, and WAY more for WAY less. Head to Wayfair.com right now to explore a HUGE outdoor selection! Download Cash App Today: https://click.cash.app/ui6m/aphxvl7b #CashAppPod As a Cash App partner, I may earn a commission when you sign up for a Cash App account. Cash App is a financial services platform, not a bank. Banking services provided by Cash App's bank partner(s). Prepaid debit cards issued by Sutton Bank, Member FDIC. Visit cash.app/legal/podcast for full disclosures. Download the DraftKings Casino app, sign up with code BASIC, and spin your favorite slots!
Training camp has started and were pumped for football. Jerry Jones is losing it even more than hes lost it and we have some hold outs around the league. Chris Paul might retire and Ben Simmons could be a Celtic (00:00:00-00:19:05). Hot Seat/Cool Throne including Hunter Biden and crack, our fishing tournament and more (00:19:00-00:49:04). We do Mt Rushmore of basic girl instagram captions(00:49:04-01:20:13). Chase Utley joins the show to talk baseball, his career in philly and los angeles, playing baseball hard, peanut butter and jellies and more (01:20:13-02:07:20). We finish with listener submitted FAQ's (02:07:20-02:25:24).You can find every episode of this show on Apple Podcasts, Spotify or YouTube. Prime Members can listen ad-free on Amazon Music. For more, visit barstool.link/pardon-my-take
What if the secret to a sustainable music career isn't just making great music, but understanding every piece of the puzzle? What if radical transparency—not polished marketing—creates the deepest fan connections? And what if sometimes the best way to grow creatively is to completely "burn it all down" and start fresh?Complete Show Notes: producerhead.substack.comEpisode Chapters[1:46] Full Stack Musician Philosophy[5:30] Planning vs. Intuition[10:51] "How Serious Are You?"[14:24] Good Stress vs. Bad Stress[16:49] Music as Community[22:04] Embracing Popular Music[27:55] Social Media Comparison Trap[31:35] Patience as Competitive Advantage[32:33] Radical Transparency[36:04] Connection as Currency[42:26] Storytelling in Music[47:23] Nashville Perspective Shift[53:16] Others' Opinions[59:11] Creative Process Evolution[1:04:32] Self-Awareness Through Music[1:09:40] Time Management[1:15:36] Daily Routines[1:21:15] Quick Hits[1:26:33] Advice: "Don't Give Up"Connect With Basic Printer* YouTube: @basicprinter* Instagram: @basicprinter* Website: https://www.basicprinter.com* Spotify: Basic Printer* Apple Music: Basic PrinterConnect With Toru* Website: torubeat.com* Instagram: @torubeat* YouTube: @torubeat* Spotify: Toru* Apple Music: ToruMy hope is that this conversation helps you unlock a bit more creativity and find progress in a way that matters to you.Let's stay connected. I regularly share ideas that help develop creative process, along with music recommendations and free resources right here on Substack.This episode was co-produced, engineered and edited by Matthew Diaz. From ProducerHead, this is Toru, and in a way, so are you. Peace. Get full access to ProducerHead at producerhead.substack.com/subscribe
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Is your annual cholesterol test giving you the full picture of your heart health? While conventional lab work is important, it often overlooks deeper, more predictive markers of cardiovascular risk. On today's episode, I'll walk you through the most advanced heart health labs that go beyond the basic lipid panel. You'll learn which markers truly matter, what they reveal about your risk for heart disease, and how to take meaningful action. Join me on today's Cabral Concept 3450 to discover the hidden cardiovascular labs most doctors miss—and why they're essential for long-term wellness. Enjoy the show, and let me know what you think! - - - For Everything Mentioned In Today's Show: StephenCabral.com/3450 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!
In this week's Fraud Friday, Laci is joined by Sara Levine & Danny Murphy (Not Another True Crime Podcast) to discuss Elizabeth Swaney, who proudly made it to the 2018 PyeongChang Winter Games, without doing a single trick in her sport. Plus, the FDA demanded Alex Jones stop advertising questionable dietary supplements as coronavirus treatments, threatening legal action if he didn't stop. Stay Schemin'! (Originally Released 06/06/2022) CON-gregation, catch Laci's TV Show, Scam Goddess, now on Freeform and Hulu!Did you miss out on a custom signed Scam Goddess: Lessons from a Life of Cons, Grifts and Schemes book? Look no more, nab your copy here on PODSWAG Follow on Instagram:Scam Goddess Pod: @scamgoddesspodLaci Mosley: @divalaciSara Levine: @saralememeDanny Murphy: @kashmeredanny Research by Kaelyn Brandt SOURCES:https://everything-everywhere.com/elizabeth-swaney-and-the-power-of-just-showing-up/https://olympics.com/en/news/elizabeth-swaney-unlikely-halfpipe-herohttps://resumes.actorsaccess.com/elizabethhttps://www.theguardian.com/us-news/2019/apr/21/elizabeth-swaney-olympics-skiing-american-ninja-warriorhttps://www.cbssports.com/olympics/news/mikaela-shiffrin-doesnt-have-anything-to-prove-to-anyone-at-the-beijing-olympics/ Subscribe to SiriusXM Podcasts+ to listen to new episodes of Scam Goddess ad-free and a whole week early. Start a free trial now on Apple Podcasts or by visiting siriusxm.com/podcastsplus.