Podcasts about Shah

Midlife is not subtle. You're disciplined, productive, training harder than ever, and still waking up at 4AM wired, gaining belly fat, and realizing the formula that used to work no longer does. In this Habits & Hustle episode, I'm joined by Dr. Amy Shah to break down why cortisol is the real driver behind stubborn weight gain and 3AM wakeups and how too much intensity can backfire after 40.  We also unpack her 30-30-3 Method and 4-3-2-1 Movement Framework so women can start a practical reset in just three days. Dr. Amy Shah is a Double Board-Certified MD, Nutritionist, and New York Times Best Selling Author. She trained in internal medicine and immunology and studied nutrition at Cornell University. Amy is the author of I'm So Effing Hungry and I'm So Effing Tired, with Hormone Havoc forthcoming. What's Discussed (02:26) Morning sunlight and short movement to stabilize cortisol (04:07) Leaving 20% unscheduled to reduce stress load (11:57) 3-5AM wake-ups and cortisol spikes (13:02) Why intense workouts increase belly fat after 40 (18:10) The 4-3-2-1 workout framework for midlife women (28:28) Alcohol, sugar, sitting, and stress as aging drivers (44:48) Sleep as the most underrated anti-aging tool (49:52) Gut health as a foundation for hormone balance Thank you to our sponsors: Rho Nutrition: Try Rho Nutrition today and experience the difference of Liposomal Technology. Use code JEN20 for 20% OFF everything at https://rhonutrition.com/discount/jen20. Prolon: Prolon is offering listeners 30% off sitewide plus a $40 bonus gift when you subscribe to their 5-Day Program! Just visit https://prolonlife.com/JENNIFERCOHEN and use the code JENNIFERCOHEN to claim your discount and your bonus gift. Therasage: Visit Therasage.com and use code JEN to get 15% off your order. Your skin deserves this level of care. Air Doctor: Head to AirDoctorPro.com and use promo code HUSTLE to get UP TO $300 off today! AirDoctor comes with a 30-day money back guarantee, plus a 3-year warranty — an $84 value, free! Magic Mind: Head over to www.magicmind.com/jen and use code Jen at checkout. Momentous: Ready to try supplements that actually do what they claim? Head to livemomentous.com and use code JEN for 35% off your first subscription.  Manna Vitality: Try it now by using the code Jennifer20 at mannavitality.com.   Amp fit If you're ready to make consistency a habit without sacrificing your sanity, check out joinamp.com/jen.  Find more from Jen:  Website: https://jennifercohen.com Instagram: @therealjencohen Books: https://jennifercohen.com/books Speaking: https://jennifercohen.com/speaking-engagement Find more from Dr. Amy Shah: Website: https://amymdwellness.com Instagram: @dramyshah Facebook: @drconfidential Youtube: @dramyshah Tiktok: @dramyshah “Hormone Havoc” out February 24th: https://amymdwellness.com/pages/books

It can take about 4 to 6 doctor's visits for women's symptoms to finally be connected to perimenopause and menopause.  So how do you know you're entering this massive transition?  In today's episode, I'm joined by women's health and nutrition expert Dr. Amy Shah for a deep dive into midlife transitions and why our healthcare system still struggles to make these critical links.  Dr. Shah shares her own beautiful ascension, revealing how a season of life that can feel destabilizing is also deeply transformative. Through tips from her own experience combined with her well-rounded medical expertise, you'll walk away with clarity and confidence. We also talk about intentionality in midlife—how to navigate new opportunities, say yes to growth, and still carve out space for yourself.  If you're ready to step into your next level with purpose and self-trust, tune in here! Amy Shah, MD  Dr. Amy Shah is a double board-certified MD and nutritionist with training from Cornell, Columbia, and Harvard. She's a gut-health expert, best-selling author, and worldwide educator in women's health. She focuses on evidence-based research in women's health and hormones, nutrition, fitness, and lifestyle medicine, helping people transform their health, digestion, and natural hormone balance. Her goal is to help you save yourself by prioritizing physical and mental health, even amidst the busiest of schedules.   IN THIS EPISODE Tips for recognizing when you're in perimenopause  Finding lifestyle strategies that work best for you in perimenopause  What changes in your body in midlife, and how to best show up in this new and different way  Changing your internal narrative and improving self-talk in perimenopause  The biggest things that should change in women's modern medicine  How to move away from a place of fear and let go of holding back in midlife  Best tips for smoothly navigating the perimenopause transition Where to get more of Dr. Amy's best midlife recommendations  QUOTES “Once I started doing that, it improved things so much. That cortisol strategy, the cortisol reset, that is what changed everything.” “What's taking me into the next phase of my life is that we don't have a lot of time. We are allowed to fail. We are all imperfect, flawed people. And if you just give yourself permission to do things that you really want to do in this life, this is the time.” “Go in with confidence, open eyes, and start doing things proactively because, like I said, your gut and your hormones are so connected that if you start improving your gut health, all of a sudden your brain health improves. Your hormone health is going to improve, and this rocky roller coaster of a transition will be so much smoother.” RESOURCES MENTIONED Order my latest book: The Perimenopause Revolution https://peri-revolution.com/ Dr. Amy's Website Sign up for Dr. Amy's Free Newsletter HERE Dr. Amy's Podcast: Save Yourself Dr. Amy on Instagram Dr. Amy's YouTube Channel RELATED EPISODES  721: No, It's Not All in Your Head: The Medical Truth About Perimenopause with Dr. Jila Senemar 704: Hormone Intelligence for Women in Midlife: How to Thrive Through Perimenopause with Dr. Aviva Romm 690: The Perimenopause Revolution: Why midlife isn't the end — it's the beginning of your most energized, powerful, and vibrant self 490: Why We Crave The Foods We Crave and What We Can Finally Do About It with Dr. Amy Shah

Gaius recounts meeting Prime Minister Mossadegh as a child, framing the current crisis within a century of failed American "engineering" in Persian affairs. They reflect on the unsustainable, "European-import" nature of the Shah's regime and conclude that foreign intervention historically backfires, leading to revolutionary outcomes inimical to American interests.1979 TEHRAN

Brandon Weichert discusses US interference in Iran, specifically the 1953 coup and Ambassador Sullivan's 1978 memo suggesting the Carter administration replace the Shah with Khomeini. 1.

Join Jim and Greg for the Monday edition of the 3 Martini Lunch as they marvel at the accomplishments of Operation Epic Fury in Iran, discuss the Iranian military's retaliatory missile strikes across the Middle East, and wonder how we get Iran to become a stable country that's not always trying to kill us.First, they react to the stunning execution, complexity, and success of Operation Epic Fury. Dozens of senior Iranian leaders are reported dead, including Supreme Leader Ayatollah Ali Khamenei, and U.S. and Israeli forces appear to have established overwhelming aerial dominance as operations continue. Jim and Greg also push back on claims that the conflict was an unprovoked war.Next, they detail Iran's military response, including missile attacks targeting multiple countries across the Middle East. At least four American service members were killed in the strikes. Jim notes that a weakened and desperate regime fighting for survival can still inflict serious damage.Finally, they try to get a handle on how the transition to a better, more responsible Iran is supposed to unfold. Does the U.S. have specific people in mind as transitional figures or long-term leaders or is expected to happen organically? Please visit our great sponsors:Stop putting off those doctors' appointments and visit https://Zocdoc.com/3ML to find and instantly book a top-rated doctor today.Go to https://CoastPay.com/MARTINI to see how you can earn up to a $2000 credit.New episodes every weekday. 

Hot flashes. Brain fog. Extra weight that won't budge. You're not imagining it — and you're not powerless. Dr. Amy Shah, MD, double board-certified physician and author of Hormone Havoc, says food is the most underused tool for navigating menopause — but most doctors never bring nutrition up. We explore her 30-30-3 method, the power of protein timing, why most women are way under the daily recommended fiber intake, which probiotic foods ease symptoms, and how small, sustainable shifts can restore your energy, sharpen your focus, and help you feel like yourself again. Fix your gut. Feel like yourself again, beauties! FOLLOW A CERTAIN AGE ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Instagram⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Facebook⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠LinkedIn⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ GET INBOX INSPO: Sign up for our newsletter ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠AGE BOLDLY⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ We share new episodes, giveaways, links we love, and midlife resources Learn more about your ad choices. Visit megaphone.fm/adchoices

A single decision can bend history, and today's Iran proves it. We trace how a string of unlikely turns—an election loss, a near miss on a Pennsylvania stage, and a hard pivot back to the White House—set the conditions for a coordinated U.S.–Israel strike that decapitated the world's top state sponsor of terror. No occupation. No open-ended ground war. Just sustained air, cyber, and intelligence pressure meant to dismantle missile stockpiles, sever proxy pipelines, and hand the next move to the Iranian people.We get candid about the stakes. Supporters call it overdue justice; critics warn of escalation and blurred lines of legality. On the streets and across the diaspora, Iranians express something rare: cautious gratitude and a hunger for a normal life. That's the hinge of the conversation—why a young, educated, urban nation that once looked modern and open could, if given breathing room, reclaim prosperity and dignity. We revisit the Shah-to-theocracy arc, the repression that followed, and the five levers that could power a comeback: demographics, human capital, energy wealth, urban infrastructure, and a living memory of freedom.We also dig into U.S. politics without flinching. The end of the Powell doctrine mindset, party rifts over strength versus restraint, and a State of the Union moment turned viral ad all collide with a broader strategic thesis: short wars, not forever wars; disruption over occupation; and moral clarity against regimes that murder their own. The risks—proxy retaliation, sleeper cells, and regional friction—are real. So is the opportunity to redraw security lines from the Gulf to the Mediterranean if terror architecture collapses and a better order emerges.If you care about foreign policy, Middle East dynamics, energy geopolitics, human rights, or the collision of strategy and values, this one's for you. Listen, share your take, and help us keep this conversation sharp. Subscribe, leave a rating, and tell a friend what surprised you most about Iran's turning point.Website: https://www.nodoubtaboutitpodcast.com/Twitter: @nodoubtpodcastFacebook: https://www.facebook.com/NoDoubtAboutItPod/Instagram: https://www.instagram.com/markronchettinm/?igshid=NTc4MTIwNjQ2YQ%3D%3D

A little white ago I stepped away from conversations about hormones, perimenopause and menopause on this podcast.Not because women's health stopped being important, for from it! It was because the conversation became louder, more crowded and, for many women, more confusing than helpful. Conflicting advice, competing experts and endless rules have left many of us wondering what actually matters, and what we should actually do day to day to feel better.In this episode, I'm joined by physician and bestselling author Dr. Amy Shah to discuss her new book, Hormone Havoc. Rather than another conversation focused solely on treatment or supplements, we talk about the practical, everyday habits that support women through perimenopause, menopause and beyond.We explore how hormones intersect with modern life, why midlife can feel uniquely overwhelming, and how small, consistent changes around nutrition, sleep, movement and recovery can make a meaningful difference.This is a calmer, clearer conversation about a stage of life that doesn't need to be feared, it just needs to be understood.In This EpisodeWhy women feel more confused about hormones than everPerimenopause as a gradual hormonal transition rather than a sudden eventThe impact of modern stress and midlife responsibilitiesMoving from dieting culture to strength and longevityDr Shah's 30–30–3 approach:30g protein in your first meal30g fibre per day3 servings of probiotic foodsGut health and hormone regulationUltra-processed foods and metabolic healthGLP-1 medications; benefits, realities and cautionsSleep, circadian rhythm and the importance of darknessAlcohol, ageing and brain healthWhy menopause can mark a powerful new phase of lifeAbout My GuestDr. Amy Shah is a double board-certified physician specialising in integrative medicine and nutrition. She is the bestselling author of I'm So Effing Tired, I'm So Effing Hungry, and Hormone Havoc, which explores how modern lifestyles influence women's hormones and how evidence-based daily habits can support healthier ageing.If this episode resonated with you, follow the podcast so you never miss future conversations like this one. If you want to share your thoughts on this conversation with me and your fellow listeners, subscribe to my Substack.Hey! Why not share your thoughts and insights to make your listening experience even better. Complete this listener survey to tell me what you want to hear: http://bit.ly/theemmagunsshow-survey Hosted on Acast. See acast.com/privacy for more information.

Yesterday the US & Israel conducted joint strikes on Iran's leadership and critical infrastructure.We are now at war.What will the likeliest implications be?To address, RANE's Mideast analyst Ryan Bohl just joined me for a livestream this morning where he provided his latest assessment of the situation and his best forecast of what lies ahead.WORRIED ABOUT THE MARKET? SCHEDULE YOUR FREE PORTFOLIO REVIEW with Thoughtful Money's endorsed financial advisors at https://www.thoughtfulmoney.com#iran #middleeast #war 00:00 - Introduction and Welcome01:25 - Details of the Joint US-Israeli Strikes on Iran03:34 - Iran's Retaliation Across the Gulf Region05:06 - Confirmation of US Casualties05:59 - Extent of Decapitation in Iranian Leadership06:57 - Structure and Resiliency of Iran's Government09:36 - Information on New Interim Leaders10:29 - Continued Iranian Command and Control10:44 - US and Israeli Strike Plans and Air Superiority11:52 - Odds of Achieving Total Air Superiority13:55 - Assessment of Iran's Response Strength16:28 - US and Israeli Intelligence Capabilities in Iran19:52 - Breakdown of US-Iran Talks20:03 - Iran's Strikes on Regional Neighbors21:07 - Potential Uniting of the Region Against Iran24:26 - Neighbors' Preferences for Stable Regime or Change26:56 - Factors Leading to the Current Escalation28:45 - Nuclear Program as the Breaking Point29:02 - Timing of the Decision to Strike Now31:12 - Striking Iran as an 80/20 Global Issue33:56 - Domestic and International Support Dynamics35:53 - Viability of Regime Influence Strategy in Iran37:23 - Likelihood of Carrot-and-Stick Approach Succeeding39:44 - Odds of Domestic Uprising Removing the Regime44:26 - Implications of Cheering Footage and Expat Reactions47:03 - Prospects for the Shah's Son Returning49:20 - Worst-Case Scenario Outcomes52:41 - Best-Case Scenario for Iran54:35 - Potential for a Better World if Conflicts Resolve57:04 - Geopolitical Competition Persisting Globally58:20 - Implications for Global Markets and Commodities59:31 - Counsel for Those Fearing World War III_____________________________________________Thoughtful Money LLC is a Registered Investment Advisor Promoter.We produce educational content geared for the individual investor. It's important to note that this content is NOT investment advice, individual or otherwise, nor should be construed as such.We recommend that most investors, especially if inexperienced, should consider benefiting from the direction and guidance of a qualified financial advisor registered with the U.S. Securities and Exchange Commission (SEC) or state securities regulators who can develop & implement a personalized financial plan based on a customer's unique goals, needs & risk tolerance.IMPORTANT NOTE: There are risks associated with investing in securities.Investing in stocks, bonds, exchange traded funds, mutual funds, money market funds, and other types of securities involve risk of loss. Loss of principal is possible. Some high risk investments may use leverage, which will accentuate gains & losses. Foreign investing involves special risks, including a greater volatility and political, economic and currency risks and differences in accounting methods.A security's or a firm's past investment performance is not a guarantee or predictor of future investment performance.Thoughtful Money and the Thoughtful Money logo are trademarks of Thoughtful Money LLC.Copyright © 2026 Thoughtful Money LLC. All rights reserved.

Welcome to The Daily Wrap Up, an in-depth investigatory show dedicated to bringing you the most relevant independent news, as we see it, from the last 24 hours (2/28/26). As always, take the information discussed in the video below and research it for yourself, and come to your own conclusions. Anyone telling you what the truth is, or claiming they have the answer, is likely leading you astray, for one reason or another. Stay Vigilant. !function(r,u,m,b,l,e){r._Rumble=b,r[b]||(r[b]=function(){(r[b]._=r[b]._||[]).push(arguments);if(r[b]._.length==1){l=u.createElement(m),e=u.getElementsByTagName(m)[0],l.async=1,l.src="https://rumble.com/embedJS/u2q643"+(arguments[1].video?'.'+arguments[1].video:'')+"/?url="+encodeURIComponent(location.href)+"&args="+encodeURIComponent(JSON.stringify([].slice.apply(arguments))),e.parentNode.insertBefore(l,e)}})}(window, document, "script", "Rumble");   Rumble("play", {"video":"v748wcq","div":"rumble_v748wcq"}); Video Source Links (In Chronological Order): Stephanie Seneff PhD Interview - Glyphosate & The Engineered Sick Care System Biotech and Pesticide Corporations Are "Winning" Under Trump's Second Administration New Tab (20) Monitor

In this episode, Dr. Mayank K. Shah, Vice President and Chief Medical Officer of Advocate Condell Medical Center, part of Advocate Aurora Health, shares how his team elevated safety and quality to top Leapfrog grades, advanced AI adoption, and is building agility to navigate regulatory uncertainty and expand community focused care.

FEBRUARY 28, 2026 HOUR 1: Live breaking news hour as reports come in that the U.S. and Israel have launched major military strikes against Iran. Peter Boyles opens phones early as listeners react in real time. Wide-ranging discussion on Iran’s history with the U.S., the Shah, oil politics, regime change, and whether this conflict spreads or stops. Callers debate Trump’s role, war aims, global fallout, and domestic consequences. Ongoing updates, retaliation reports, listener texts, and historical context throughout the hour.See omnystudio.com/listener for privacy information.

FEBRUARY 28, 2026 HOUR 2: After U.S. and Israeli strikes on Iran, Peter Boyles brings in Baylor’s David A. Smith to break down what it means — and how it could end. From the Shah and the Cold War to oil politics and regime change, it’s a fast-moving hour on history, strategy, and the big question: now what?See omnystudio.com/listener for privacy information.

As Donald Trump and his Administration threaten to attack Iran, their motivations remain unclear. Does the President want to force Iran to make a nuclear deal, to replace the one that he scrapped in his first term, or is he really seeking regime change? To understand how this all might play out, David Remnick speaks with Karim Sadjadpour, a policy analyst at the Carnegie Endowment for International Peace, who writes about the Middle East for Foreign Affairs and other publications. Citing the disastrous precedents in Afghanistan and Iraq, Sadjadpour notes, “the last two decades has proven that we don't have the ability to dictate . . . who comes to power the day after a military attack.” Plus, After protests over the economy erupted across Iran late last year, reports emerged that the regime was killing protesters. Donald Trump threatened to intervene, but did not. Estimates vary widely, but some note that thirty thousand people or more may have been killed. Now, as the U.S. sends a huge military force to the Gulf, Iranians are waiting for war—and many in the country are in the shocking position of hoping for conflict, if it will end the Ayatollah's government. The reporter Cora Engelbrecht has been recording her conversations with sources on the ground about what that could mean. Their voices were altered or overdubbed for our story, to protect them from reprisal. New episodes of The New Yorker Radio Hour drop every Tuesday and Friday. Join host David Remnick as he discusses the latest in politics, news, and current events in conversation with political leaders, newsmakers, innovators, New Yorker staff writers, authors, actors, and musicians.

Women over 40 are the most understudied population in modern medicine. In this powerful and overdue conversation, Darin sits down with Dr. Amy Shah to unpack the massive blind spots in women's health — from perimenopause and menopause to cortisol shifts, brain fog, gut bacteria collapse, muscle loss, and the social isolation epidemic affecting women in midlife. Dr. Shah reveals why hormone labs often don't tell the full story, why 95% of Americans are fiber deficient, how fermented foods regulate inflammation, and why morning sunlight may be one of the most powerful hormone resets available — and it's free. This episode is more than symptom management. It's a blueprint for reclaiming power during one of the most misunderstood transitions in a woman's life.     What You'll Learn Why women weren't required in medical research until 1993 How perimenopause is diagnosed by symptoms — not lab tests The hormonal cascade: hypothalamus → pituitary → ovaries → whole-body effects Why fiber is the missing hormone regulator The 30-30-3 framework: protein, fiber & fermented foods The estrobolome and how gut bacteria regulate estrogen Why cortisol sensitivity increases during perimenopause The circadian reset protocol: morning light & nighttime boundaries Why recovery becomes more important than high-intensity stress The female friendship effect & oxytocin biology Hormone therapy myths — and what the research actually shows Why menopause may actually be a leadership upgrade     Chapters 00:00:00 – Welcome back Dr. Amy Shah 00:00:29 – Novelty, brain aging & why time "speeds up" 00:02:03 – The hormone cascade: hypothalamus, pituitary & endocrine signaling 00:03:39 – The most understudied population in medicine: women over 40 00:04:11 – Women excluded from research until 1993 00:05:06 – Ambien example: why women metabolize drugs differently 00:08:14 – Cultural silence around menopause 00:09:48 – Anxiety, palpitations, carpal tunnel: unrecognized hormone symptoms 00:11:17 – Gut-brain connection & why nutrition is medicine 00:15:11 – The 30-30-3 method explained 00:16:10 – Why fiber drops during perimenopause 00:17:23 – Simple fiber sources that extend longevity 00:19:00 – Fermented foods & lowering inflammation 00:21:01 – Why Americans lost fermented foods 00:22:26 – Circadian biology: every cell runs on light 00:23:46 – Morning sunlight & hormone regulation 00:26:25 – Late-night eating & insulin resistance 00:28:20 – Cortisol spikes in perimenopause 00:29:41 – Why high achievers crash in midlife 00:31:11 – Walking as cortisol-lowering exercise 00:32:24 – Why hormone labs don't show perimenopause 00:33:38 – Key symptoms: sleep, fat redistribution, brain fog 00:35:24 – The estrobolome: gut bacteria & estrogen recycling 00:36:30 – Gut bacteria change within three days 00:38:38 – Andropause vs menopause differences 00:41:21 – Hormone therapy: what's proven & what's misunderstood 00:44:53 – Peak bone & muscle before 30 00:46:02 – Exercise for longevity vs punishment 00:47:55 – The community & oxytocin effect 00:49:49 – Female friendship & cortisol reduction 00:52:18 – Intergenerational connection & health 00:57:05 – Gut bacteria & proximity effect 01:00:24 – The Grandmother Hypothesis 01:02:15 – Menopause as leadership evolution 01:04:28 – You can build muscle, brain & bone at any age 01:05:16 – Rewriting the narrative for women's health     Thank You to Our Sponsors Therasage: Go to www.therasage.com and use code DARIN at checkout for 15% off Shakeology – Shakeology-All in One Nutrition: Get 15% off with code SUPERLIFE at Shakeology.com. Our Place: Toxic-free, durable cookware that supports healthy cooking. Use code DARIN for 10% off at fromourplace.com.     Join the SuperLife Community Get Darin's deeper wellness breakdowns — beyond social media restrictions: Weekly voice notes Ingredient deep dives Wellness challenges Energy + consciousness tools Community accountability Extended episodes Join for $7.49/month → https://patreon.com/darinolien     Find More From Dr. Amy Shah: Website: amymdwellness.com Instagram: @dramyshah Book: Hormone Havoc: A Science-Backed Protocol for Perimenopause and Menopause     Find More from Darin Olien: Instagram: @darinolien Podcast: SuperLife Podcast Website: superlife.com Book: Fatal Conveniences      Key Takeaway Perimenopause is not decline. It's a biological transition that requires new inputs, more recovery, more fiber, more protein, more community, more light. When women understand what's happening inside their bodies, they stop thinking they're "falling apart", and start stepping into power.  

Dr. Nirav Shah joins our host Cate Blackford on the podcast to discuss his run for Maine governor and how his background in public health as the former director of the Maine CDC shapes his approach to leadership. He talks about the importance of competent state governance, clear communication and rebuilding public trust. Shah outlines his plans… The post Nirav Shah on public health, housing and the race for governor first appeared on Maine Beacon.

Chas & Dr Dave discuss The Porn Capital of The World, Elephants In Mouseholes, and If You're Having Tariff Problems I Feel Bad For You Son, Cos I Got 99 Actions To Address A Foreign Threat But Raising Revenue Ain't One WARNING: This episode of PEP may contain explicit language.   Timestamps: 0:00 - Introducing: Dr Dave 1:56 - Grateful (90s Dentistry, Schwank) 11:32 - Tariffs Ruling 58:54 - Tariff Politics 1:21:54 - State of the Union 1:23:59 - Continuing with Topics That Actually Matter 1:43:56 - Attacking Iran? 2:11:44 - Obama Apes Controversy 2:28:37 - UAE Payoff 2:41:38 - Texas Dems Senate Primary 2:57:04 - Unleashed: Colbert Interview   SHOW LINKS: *Chat with the PEPpers on the Discord Server: https://discord.com/invite/WxDD2PPvaW   THE (UPDATED) DR DAVE BOOK CLUB MASTERLIST: Connie Willis - Doomsday Book & To Say Nothing of the Dog (Mentioned 4:26, Ep 244) Richard Yates - Revolutionary Road  (Mentioned 1:48:45, Ep 240) Michael Lewis - Who Is Government? (Mentioned 2:19:59, Ep 235) Orlando Whitfield - All That Glitters (Mentioned 2:34:37, Ep 232) John Lyons - Balcony Over Jerusalem (Mentioned 2:45:26, Ep 231) Yukio Mishima - Spring Snow (Mentioned 2:35:12, Ep 227) John Steinbeck - Cannery Row (Mentioned 02:39, Ep 226) David Simon & Ed Burns - The Corner: A Year in the Life of an Inner-City Neighborhood (Mentioned 2:21:40, Ep 225) William Appleman Williams - The Tragedy of American Diplomacy (Mentioned 2:11:23, Ep 222) Mahmood Mamdani - Good Muslim, Bad Muslim (Mentioned 2:07:14, Ep 220) Carlo Rovelli - The Order Of Time (Mentioned 06:36, Ep 220) Carlo Rovelli - Reality Is Not What It Seems (Mentioned 06:36, Ep 220) Ryszard Kapuściński - Shah of Shahs (Mentioned 2:21:27, Ep 217) Ervand Abrahamian - Khomeinism (Mentioned 2:23:19, Ep 217) Anthony Seldon - Truss at 10 (Mentioned 1:36:09, Ep 215) Steven Teles - The Conservative Legal Movement (Mentioned 2:12:12, Ep 215) Amin Maalouf - The Crusades Through Arab Eyes (Mentioned 4:32, Ep 214) Geoffrey Blainey - The Causes Of War (Mentioned 43:49, Ep 198) Margaret Levi - Of Rule And Revenue (Mentioned 1:11:16, Ep 195) Margaret Levi - Consent, Dissent, and Patriotism (Mentioned 1:11:16, Ep 195) Sayaka Murata - Convenience Store Woman (Mentioned 2:14, Ep 194) Sid Meier - Sid Meier's Memoir! (Mentioned 16:30, Ep 178) David Simon & Ed Burns - The Corner (Mentioned 8:40, Ep 178) Maurice O. Wallace - King's Vibrato (Mentioned 14:26, Ep 164) Edward S. Herman and Noam Chomsky - Manufacturing Consent - (Mentioned 32:12, Ep 164) Robert Plunket - My Search For Warren Harding (Mentioned 1:49:12, Ep 158) Ian Lambot & Greg Girard - City of Darkness Revisited (Mentioned 39:25, Ep 157) Max Chafkin - The Contrarian (Mentioned 32:18, Ep 155) Claire Conner - Wrapped In The Flag (Mentioned 31:42, Ep 155) Rita Abrahamsen, Mike Williams et al - Global Right (Mentioned 31:12, Ep 155) Philip Gorski and Samuel Perry - The Flag And The Cross (Mentioned 30:49, Ep 155) Cynthia Miller-Idriss - Hate In The Homeland (Mentioned 30:10, Ep 155) Cory Doctorow & Rebecca Giblin - Chokepoint Capitalism (Mentioned 34:55, Ep 150) Elizabeth Ingleson - Made In China (Mentioned 31:50, Ep 150) John Corrigan - Religious Intolerance, America, and the World (Mentioned 1:16:18, Ep 141) Gérard Prunier - From Genocide to Continental War (Mentioned 48:18, Ep 141) Liu Cixin, - The Three Body Trilogy (Mentioned 1:11:04, Ep 136) Tilman Allert - The Hitler Salute (Mentioned 22:03, Ep 134) Philip Roth - Nemesis (Mentioned 1:56, Ep 133) Joshua Cohen - The Netanyahus Zeke Faux - Number Go Up Michael Paul Rogin - The Intellectuals and McCarthy Cathy Kramer - The Politics of Resentment Naomi Klein - Doppelganger Maria Bamford - Sure, I'll Join Your Cult Wendy Brown - States Of Injury Corey Robin. - The Reactionary Mind Patricia Lockwood - No One Is Talking About This David Cay Johnston - The Making of Donald Trump Jane Mayer - Dark Money Harry Frankfurt - On Bullshit Stephen King - The Dead Zone Elle Hardy - Beyond Belief Federico Finchelstein - From Fascism to Populism in History Robert Jervis - Why Intelligence Fails Alex Haley and Malcolm X - The Autobiography of Malcolm X Jonathan Haidt - The Righteous Mind David Graeber - Debt: The First 5000 Years Jerry L. Mashaw - Creating The American Administrative Constitution Brian Balogh - A Government Out of Sight Paul Connerton - How Societies Remember Paul Connerton - How Modernity Forgets Catherine Green and Sarah Catherine Gilbert - Vaxxers John Zaller - The Nature and Origins of Mass Opinion Matthew Karp - This Vast Southern Empire Robert Fatton - The Guise of Exceptionalism Anatol Lievin - Climate Change and the Nation State: The Realist Case James Alfred Aho - The Politics of Righteousness The substack that Dr Dave apparently plagiarises liberally from! https://luke.substack.com/ James Beverley - God's Man in the White House Jane Chi Hyun Park - Yellow Future Matthias Gardell - In The Name of Elijah Muhammad Gosta Esping-Andersen - The Three Worlds of Welfare Capitalism Suzanne Mettler - The Submerged State Brendon O'Connor - Anti-Americanism and American Exceptionalism James Morone - Hellfire Nation Nathan Kalmoe - With Ballots and Bullets Winnifred Fallers Sullivan - The Impossibility of Religious Freedom Mary L. Trump - Too Much And Never Enough Richard Cooke - Tired of Winning Jon Ronson - So You've Been Publicly Shamed Rodney Tiffen, Ross Gittins, Anika Gauja, David Smith, Brendon O'Connor - How America Compares Tony Horwitz - Confederates In the Attic Ghassan Hage - White Nation George Lakoff - Women, Fire and Dangerous Things George Lakoff - Metaphors We Live By Michelle Alexander - The New Jim Crow Alex S. Vitale - The End of Policing Dave Cullen - Parkland: Birth of a Movement Thomas Sugrue - The Origins of the Urban Crisis Rick Pearlstein - The Invisible Bridge Rick Pearlstein - Before the Storm Rick Pearlstein - Nixonland Brian Doherty - Radicals for Capitalism Leon Festinger, Henry W. Riecken, Stanley Schachter - When Prophecy Fails Nancy L. Rosenblum & Russell Muirhead - A Lot Of People Are Saying Benjamin Moffitt - The Global Rise of Populism Jon Krakauer - Missoula   THANK YOU FOR YOUR ATTENTION TO THIS MATTER!

In this episode, Dr. Mayank K. Shah, Vice President and Chief Medical Officer of Advocate Condell Medical Center, part of Advocate Aurora Health, shares how his team elevated safety and quality to top Leapfrog grades, advanced AI adoption, and is building agility to navigate regulatory uncertainty and expand community focused care.

What if your health wasn't just shaped by what you eat—but by what's hidden in your medications?In this episode, Rip sits down with pharmacist-scientist Dr. Sachin Shah, a leading voice in medication transparency and patient safety. Together, they explore why food truly belongs at the center of health, how modern medicine sometimes misses the human in healthcare, and why knowing what's inside your pills can be just as important as knowing what's on your plate.Dr. Shah also breaks down alpha-gal syndrome—a tick-bite–triggered condition that can make people allergic to red meat and certain medications—while also sharing hopeful, forward-looking ideas around heart health, non-invasive therapies, and the power of informed choices.This is a conversation about clarity, care, and taking your health back into your own hands—with compassion, curiosity, and a whole lot of heart.Episode WebpageWatch the Episode on YouTube

In this episode of Scouting for Growth, Sabine VanderLinden sits down with Manish Shah, President and Chief Product Officer at Majesco, to explore the rapidly changing landscape of insurance.  Together, they examine how AI is shifting the industry from being purely a protector to one that also focuses on prevention and dynamic participation. The conversation covers everything from the persistent protection gap and the urgent need for behavioral—not just technological—transformation in insurance to the practical realities and fears surrounding the implementation of agentic AI systems.  Manish Shah shares actionable insights on overcoming internal resistance, building trust with customers, and the importance of leadership courage. Throughout, listeners will gain an insider's view on how insurance models are transforming and what sets bold, future-ready leaders apart. KEY TAKEAWAYS I was delighted to welcome Manish Shah to explore how the insurance industry is being transformed at its core. Our discussion began with the fundamental premise that insurance is built on trust and a promise of protection—yet today, both are being challenged by shifting customer expectations, legacy systems, and the rapid evolution of AI technologies.  Manish emphasized that closing the protection gap is not merely an issue of customer education but primarily a challenge of product and experience design. If customers do not understand or value our offerings, it's a failure of design, not comprehension. We agreed that the path to genuine transformation must be grounded in a behavioral shift—beyond technology upgrades or business process reengineering. Transformation executives must start by listening deeply to customers, adapting to their evolving needs, and fostering a culture that is not afraid to take bold risks rather than settle for incremental change. The conversation also delved into how AI, when embedded into the core—not bolted on as an afterthought—can help insurers move from process-led to truly human-centered operations. This enables better capacity, more personalized experiences, and the ability to anticipate rather than react to customers' needs. Crucially, Manish Shah articulated the importance of trust, transparency, and auditability in the AI era: true trust is built through consistent, clear, empathetic engagement, supported by AI that augments—not replaces—human judgment. The insurers that will thrive in the next 3-5 years are those who are brave enough to rethink their business models, leverage intelligent, agentic cores, and prioritize behavioral change.  The future belongs to those willing to become active partners in their customers' lives, focused on prevention, participation, and peace of mind. BEST MOMENTS “If our customers don't understand or see the value in the product, then it is a design problem. It's not really a customer problem or an education problem. “Trust is built in small moments, not in any marketing material or strategic deck.”  “If we can actually execute well as an industry, insurance should feel more like a proactive safety net than a just reactive payment mechanism.”  “The brave ones… are those who are willing to rethink their business model and not just the tech stack.”  ABOUT THE GUEST  Manish Shah is the President and Chief Product Officer at Majesco, a leader at the intersection of technology, product strategy, and insurance industry expertise.  With over 30 years in the insurance sector, Manish Shah has been both a witness and a driver of major transformation, from the analog days of the industry to today's AI-driven innovation. He is particularly passionate about embedding intelligence into the foundation of insurance operations—not just talking about AI, but delivering it as an engine of change.  At Majesco, Manish Shah oversees strategy for their cloud-native, intelligent core platform, with a special focus on agentic workflows, operational effectiveness, and preparing insurers for future challenges and opportunities in P&C, Life, Health, and Benefits. If you want to connect with Manish Shah, he encourages open dialogue and learning across the industry. ABOUT THE HOST Sabine VanderLinden is a corporate strategist turned entrepreneur and the CEO of Alchemy Crew Ventures. She leads venture-client labs that help Fortune 500 companies adopt and scale cutting-edge technologies from global tech ventures. A builder of accelerators, investor, and co-editor of the bestseller The INSURTECH Book, Sabine is known for asking the uncomfortable questions—about AI governance, risk, and trust. On Scouting for Growth, she decodes how real growth happens—where capital, collaboration, and courage meet. If this episode sparked your thinking, follow Sabine VanderLinden on LinkedIn, Twitter, and Instagram for more insights. And if you're interested in sponsoring the podcast, reach out to the team at hello@alchemycrew.ventures

The Hidden Signs of Perimenopause (And How to Fix Your Hormones) | Dr. Amy ShahAre you feeling tired, struggling to recover from your workouts, or noticing changes in your body that you just can't explain? You might be told it's just a normal part of "getting older," but the truth is, hormonal shifts can actually start in your 30s!In this episode, I'm sitting down with Dr. Amy Shah to uncover the hidden signs of perimenopause that even doctors often miss. We dive deep into the powerful connection between your gut, brain, and hormones, and talk about why society's pressure for women to make themselves "smaller" is actually destroying our health.If you are ready to reclaim your energy and build true strength in midlife, Dr. Shah shares her incredibly simple "30-33 Framework" to help you overhaul your gut health and balance your hormones—without restrictive dieting.In this episode, we cover:The Mindset Shift: Why we need to stop shrinking ourselves and start getting STRONGER.Perimenopause Truths: Why hormone changes start way earlier than you think (and the symptoms to look out for).The 30-3-3 Framework: Dr. Shah's exact science-backed protocol (Protein, Fiber, and Probiotics) to heal your gut.Circadian Rhythms: Why your gut bacteria crave sunlight and how modern technology is making us tired.The 7-Day Reset: How to start taking action today with small, 1% improvements.Connect with Dr. Amy Shah:Read her new book: Hormone Havoc (Available everywhere books are sold!)Website: amymdwellness.comInstagram & TikTok: @DrAmyShah

Dr. Lakshmi Rajdev and Dr. Manish Shah join the podcast to discuss the updated guideline on immunotherapy and targeted therapy in unresectable locally advanced, advanced, or metastatic gastroesophageal cancer. They share first-line and subsequent-line recommendations for both gastroesophageal adenocarcinoma and esophageal squamous cell carcinoma based on actionable biomarkers including PD-L1 expression, MMR and/or MSI, CLDN18.2 expression, and HER2 status. They note the importance of the algorithms and tables in the guidelines that provide visual illustrations and quick reference guides of the evidence-based recommendations. They also comment on ongoing and recently presented trials that may impact future guidelines in this space. Read the full guideline, "Immunotherapy and Targeted Therapy for Advanced Gastroesophageal Cancer: ASCO Guideline Update" at www.asco.org/gastrointestinal-cancer-guidelines" TRANSCRIPT This guideline, clinical tools and resources are available at www.asco.org/gastrointestinal-cancer-guidelines. Read the full text of the guideline and review authors' disclosures of potential conflicts of interest in the Journal of Clinical Oncology,  https://ascopubs.org/doi/10.1200/JCO-25-02958      Timestamps ·       00:00 – 02:15 Introduction and Overview ·       02:16 - 08:20 First-line treatment for patients with pMMR/MSS, HER2-negative gastroesophageal adenocarcinoma ·       08:21 –10:29 First-line treatment for patients with pMMR/MSS, HER2-positive gastroesophageal adenocarcinoma ·       10:30 – 14:39 First-line treatment for patients with dMMR/MSI-H, gastroesophageal adenocarcinoma ·       14:40 – 18:03 First-line treatment for ESCC ·       18:04 – 22:04 Second- and third-line therapy for gastroesophageal adenocarcinoma and ESCC ·       22:05 – 24:38 Importance of guideline ·       24:39 – 27:45 Outstanding questions and future research   Brittany Harvey: Hello and welcome to the ASCO Guidelines podcast, one of ASCO's podcasts delivering timely information to keep you up to date on the latest changes, challenges, and advances in oncology. You can find all the shows, including this one, at asco.org/podcasts.   My name is Brittany Harvey, and today I am interviewing Dr. Lakshmi Rajdev from the Icahn School of Medicine at Mount Sinai and Dr. Manish Shah from Weill Cornell Medicine, co-chairs on "Immunotherapy and Targeted Therapy for Advanced Gastroesophageal Cancer: ASCO Guideline Update." Thank you for being here today, Dr. Rajdev and Dr. Shah. Dr. Lakshmi Rajdev: Thank you. Dr. Manish Shah: Thank you for having us. It is wonderful. Brittany Harvey: And then just before we discuss this guideline, I would like to note that ASCO takes great care in the development of its guidelines and ensuring that the ASCO conflict of interest policy is followed for each guideline. The disclosures of potential conflicts of interest for the guideline panel, including Dr. Rajdev and Dr. Shah, who have joined us here today, are available online with the publication of the guideline in the Journal of Clinical Oncology, which is linked in the show notes. So then to dive into what we are here today to talk about, Dr. Shah, I would like to start first with what prompted the update to this guideline, which was previously published in 2023, and what is the scope of this updated guideline? Dr. Manish Shah: Yes, terrific. So even in the last few years, the pace of drug development in gastroesophageal cancers has just been astounding. So, what prompted this guideline is actually the practice-changing results for a new biomarker, CLDN18.2 hat was based on the GLOW and SPOTLIGHT studies, as well as a practice-changing study in HER2-positive disease where we added pembrolizumab to trastuzumab and chemotherapy for tumors that are HER2-positive and PD-L1 CPS 1 or greater. And then there were also new studies and new approvals in esophageal squamous cell cancer that you will hear about as well. So there were several studies, overall more than 5,000 patients were reported on, and that led to several new therapies, new indications, and it really necessitated this guideline. Brittany Harvey: Excellent. It is great to hear about all of these exciting updates in this space. So then to next review the key recommendations of this guideline by clinical question that the expert panel addressed. So, Dr. Rajdev, what is the recommended first-line treatment for patients with proficient mismatch repair, microsatellite stable, HER2-negative gastroesophageal adenocarcinoma? Dr. Lakshmi Rajdev: Thank you for that question. So historically, we have sort of used fluoropyrimidine and platinum doublets, which yielded a survival of about one year. More recently, immunotherapy and targeted therapy options have improved outcomes in patients with advanced esophageal and gastric adenocarcinoma, as well as squamous cell carcinoma. Patients with gastric and GE junction adenocarcinoma have a high rate of actionable alterations, so it is imperative that physicians test the following biomarkers upfront so that it can help guide therapy. The markers recommended by the ASCO panel are HER2, MMR or MSI, CLDN18.2, and PD-L1. And also, it was recommended to use NGS if feasible in this patient population. HER2, as we know, is expressed in about 15% to 25% of patients; PD-L1 expression occurs in about 80% of patients; MSI-high, deficient MMR is present in about 5% to 8% of patients; and CLDN18.2 expression is present in about 40% of patients. There is, of course, biomarker overlap. About 13% to 22% of CLDN18.2 patients are also PD-L1 positive. For patients with pMMR or microsatellite stable HER2-negative disease with PD-L1 expression greater than 1 and absence of CLDN18.2, the panel recommended a first-line therapy with fluoropyrimidine and platinum-based therapy in combination with immunotherapy. These recommendations stem from large phase 3 trials, and the agents approved in the United States are pembrolizumab, nivolumab, and tislelizumab. It has been shown that immunotherapy benefit is greater in patients with higher PD-L1 expression, and it is not possible to comment on the individual PD-L1 cutoff scores and sort of identify the optimal PD-L1 cutoff score that sort of balances benefits and harms. But what is recommended is that immunotherapy-based treatments can be offered in patients with a CPS score of greater than 1. With regard to the choice of immunotherapy agents, that is pembrolizumab, nivolumab, or tislelizumab, these agents are considered to have similar efficacy, and the selection of an agent could be based on dosing schedule, cost considerations, toxicity, and the method of administration. Typically, clinicians should avoid withholding the start of chemotherapy while awaiting biomarker testing, depending on the clinical scenario. Now, for patients with pMMR microsatellite stable disease that is HER2-negative with PD-L1 expression less than 1 and positive CLDN18.2 expression, zolbetuximab-based treatments or in combination with chemotherapy is recommended, and this is based on two global phase III randomized controlled trials, the GLOW and the SPOTLIGHT. And across both studies, the hazard ratio for the overall survival was 0.78, and similarly, there was also an improvement in progression-free survival favoring the zolbetuximab group compared to the chemotherapy group alone. An important note is that nausea, vomiting is commonly associated with zolbetuximab-based treatments, and the panel recommended prophylactic antiemetics, adjusting zolbetuximab infusion rates, pausing infusion temporarily, using non-prophylactic antiemetics, and hydration intravenously prior to discontinuation of zolbetuximab-based chemotherapy. So effective handling of the GI-related symptoms with zolbetuximab is recommended prior to discontinuation of therapy. Now, for patients with pMMR microsatellite stable HER2-negative gastric, GE junction adenocarcinoma with PD-L1 expression greater than 1 and CLDN18.2 positivity, the ones with the dual expression with CLDN18.2 as well as PD-L1 chemotherapy, the choice of therapy can be based on the degree of PD-L1 expression, the toxicity profile, the burden of symptoms, and the anticipated improvement in symptoms associated with response to treatment, the patient comorbidities, the prior medical and treatment history. So this decision needs to be made on a case-by-case basis, and these are some of the factors that we suggested that could potentially influence the choice of therapy. For patients with pMMR microsatellite stable disease that is HER2-negative and a PD-L1 expression less than 1 and an absence of CLDN18.2 expression, first-line therapy with fluoropyrimidine and platinum-based chemotherapy is recommended. So you can see we have segmented out patients based on PD-L1 expression, pMMR and microsatellite stable disease expression, and also based on CLDN expression. Brittany Harvey: Absolutely. And that first point you noted, I think is really important, that biomarker testing is really critical for treatment decision-making in this space. So then the next subgroup of patients that the panel looked at, Dr. Shah, what first-line therapy is recommended for patients with proficient mismatch repair, microsatellite stable, HER2-positive gastroesophageal adenocarcinoma? Dr. Manish Shah: So this was an update from a few years ago. So we have known for 15 years now that if you are HER2-positive, you should get trastuzumab plus chemotherapy. That was based on the ToGA trial. And the update now is based on a trial called KEYNOTE-811, where it examined the addition of pembrolizumab to trastuzumab and chemotherapy versus trastuzumab and chemotherapy, and there was a progression-free and overall survival benefit. And again, here, the biomarkers are important. If your CPS PD-L1 is less than 1, we would not recommend Pembrolizumab in that setting, so you would still get trastuzumab and chemotherapy. But if it is 1 or greater, the PD-L1 CPS score, then we do recommend pembrolizumab unless there is a contraindication to immunotherapy. The take-home message really is from the onset of diagnosis, please check your biomarkers. And I will just, it is worth repeating, it is important to check your PD-L1 status, HER2 status, mismatch repair status, and CLDN18.2 status. And then the optimal therapy, and it is outlined in the publication, is really biomarker-driven. We know that if we are able to hit the target that is overexpressed, we are going to have a better outcome. And Dr. Rajdev did mention where there is overlap, there can be a lack of data, and that is where we are with both PD-L1 positive and CLDN positive. Here we do have data in HER2-positive cases where if you are both HER2-positive and PD-L1 positive, you would combine trastuzumab and pembrolizumab for the best outcomes. Brittany Harvey: Understood. I really appreciate you detailing what is most important for each individual biomarker combination that patients may have. So then following that, Dr. Rajdev, what does the expert panel recommend for first-line treatment for patients with esophageal squamous cell carcinoma that is not amenable to definitive chemoradiation? Dr. Lakshmi Rajdev: There are three phase III randomized clinical trials that have influenced practice in patients with esophageal squamous cell carcinoma examining the benefit of immunotherapy in this patient population. The RATIONALE-306 was a randomized trial of tislelizumab plus chemotherapy with platinum and fluoropyrimidine or paclitaxel versus placebo with chemotherapy. And then you have the KEYNOTE-590, which compared pembrolizumab plus chemotherapy versus chemotherapy alone. And then you have CheckMate-648, which included comparisons of nivolumab plus chemotherapy versus nivolumab plus ipilimumab or chemotherapy. And the primary endpoints for these studies were overall survival, and they did look at subgroups with PD-L1 expression. They used TPS score greater than 1% in CheckMate-648 and PD-L1 CPS greater than 10 in KEYNOTE-590. The bottom line is that the overall hazard ratio for overall survival across this patient population was 0.72. So clearly, there is benefit in patients that express PD-L1 CPS greater than 1 for benefit for the addition of immunotherapy. Now, the benefit again in patients with a PD-L1 expression less than 1 remains limited, and so the panel has made a recommendation for using immunotherapy in combination with platinum-based chemotherapy in patients with a PD-L1 greater than 1. Again, we know that it is hard to make recommendations on what PD-L1 cutoffs are recommended in this patient population, meaning that should it be limited to patients with a PD-L1 of 1 to 4 or greater than 10? I think that the general consensus that has been gleaned from the data is that the higher the PD-L1 expression, the greater the benefit. I do want to comment on another option that is available in patients with squamous cell carcinoma compared to adenocarcinoma, and that is the combination of nivolumab and ipilimumab. Now, in CheckMate-648, nivolumab with ipilimumab was also recommended as a treatment option in patients that have a PD-L1 score of greater than 1. There was a survival benefit demonstrated with this combination compared to chemotherapy alone. And an important observation in this study is that, although there was a slightly increased rate in early death, but there was really no significant difference in PFS and OS compared to chemotherapy alone. Importantly, the treatment appeared to be pretty well tolerated by the study population. There was a notable difference in the objective response rate, which was 35% in the nivolumab plus ipilimumab group compared to patients receiving nivolumab and chemotherapy, where it was 53%. So superiority is, so the importance of chemotherapy in patients with esophageal squamous cell carcinoma is to be noted. However, there is no difference in overall survival and progression-free survival when using the combination of nivolumab and ipilimumab, and thus it affords a chemotherapy-free option for this patient population with esophageal squamous cell carcinoma and a CPS with a score of greater than 1. Brittany Harvey: Understood. I appreciate you reviewing the evidence underpinning those recommendations as well. So then the next patient population that the guideline panel addressed, what first-line therapy is recommended for patients with deficient mismatch repair, microsatellite instability-high, gastroesophageal adenocarcinoma or esophageal squamous cell carcinoma? Dr. Lakshmi Rajdev: The rate of MSI-high expression is about 3% to 7% across different studies. Now, the KEYNOTE-158 was a tumor-agnostic study in patients with non-colorectal cancers, and again, the problem with the MSI-high population, given that it is so rare, the numbers in the individual studies are fairly small. But consistent outcomes do emerge, indicating high response to immunotherapy. So in KEYNOTE-158, a response rate of about 46% was noted. The number of patients was small, it was about 24. In CheckMate-649, which is a study of chemotherapy plus or minus nivolumab in patients with advanced gastric adenocarcinoma, there was again a very small number of patients, and patients that were MSI-high or deficient MMR did experience substantial benefits with the addition of immunotherapy, with hazard ratios in the order of about 0.38. In KEYNOTE-062, again, it was a very small number of patients, again about 6% or so, and similar to CheckMate-649, a substantial benefit was noted in combination with chemotherapy, but also there were benefits noted with pembrolizumab alone. The RATIONALE-305 again was a study of tislelizumab in combination with chemotherapy and similarly showed benefits to the combination of chemotherapy plus immunotherapy in this patient population. I think that we are all aware of the dramatic benefits of immunotherapy in this particular subset of patients, deficient MMR MSI-high, and also we have seen in CheckMate-649 they did have a subset of patients that received nivolumab and ipilimumab. And in this patient population, they noted unstratified hazard ratio of 0.28. So I think that the overall consensus is that immunotherapy is a very important treatment modality in patients with deficient MMR MSI-high disease, given that a lot of the trials in gastroesophageal adenocarcinoma have utilized chemotherapy-based options, that is certainly a recommendation of the panel to use chemotherapy in combination with immunotherapy. However, on a case-by-case basis, the panel recommended immunotherapy alone as well, and given the high response rates noted in trials across different diseases as well as noted in this disease as well. Brittany Harvey: Certainly. And I appreciate you both for reviewing these first-line recommendations. So moving to later lines of therapy, Dr. Rajdev, what recommendations did the expert panel make for second or third-line therapy for gastroesophageal adenocarcinoma and esophageal squamous cell carcinoma? Dr. Lakshmi Rajdev: So, I think that the RAINBOW trial that investigated the utility of the addition of ramucirumab as second-line therapy has been around since 2014, and those results have led to the addition of ramucirumab to taxane-based therapy in the second-line setting. Based on the utilization of oxaliplatin and platinum-based therapy in the front-line setting, there may be patients that have an underlying neuropathy, and so we wanted to really include treatment options for this patient population so that an agent that is less neurotoxic could also be recommended in combination with ramucirumab. The RAMIRIS trial is one such trial where ramucirumab was combined with FOLFIRI, and it demonstrated benefit in combination with ramucirumab. So we have listed that as a potential treatment option for patients in the second-line setting who may have an underlying neuropathy or even for whatever reason that based on the toxicity profile, that needs to be the preferred option by a physician, that recommendation is new from the older guidelines that we have. With regard to the utility of PD-1 inhibitors, there really has been no benefit noted in the second-line setting with regard to overall survival or progression-free survival, so no recommendation is made for that option. I think an important study that has been recently presented is the DESTINY-Gastric04 trial, which really has been practice-changing and has led to the recommendation for trastuzumab deruxtecan in patients that have HER2-positive metastatic gastric or GE junction adenocarcinoma. Now, this is a phase III trial in patients who retained HER2-positive disease after progressing on front-line trastuzumab-based treatments, and the comparator for this trial was trastuzumab deruxtecan versus ramucirumab plus paclitaxel. There was significant improvement and progression-free survival in patients that received trastuzumab deruxtecan. The patients that were excluded from the trial are patients that have pulmonary problems, interstitial lung disease; that is one of the toxicities of this particular agent, and close monitoring and prompt initiation of therapy such as glucocorticoid treatment in patients who develop this toxicity was also highlighted by the panel. So to summarize, the new guidelines highlight the possibility of FOLFIRI plus ramucirumab as a second-line option and then trastuzumab deruxtecan as a later-line option in patients that still retain HER2 expression. And that is very important because the trial did retest patients whether they expressed HER2. As we know, in a substantial number of patients, there is downregulation of HER2, and there is emerging data that the benefit for subsequent HER2-directed therapies is best noted in patients that still retain HER2 expression. Brittany Harvey: Great. So as our listeners have heard, there are many recommendations and new treatment options for advanced gastroesophageal cancer. Dr. Shah, earlier you highlighted the importance of biomarker testing, but I would like to hear in your view, what is the importance of this guideline and how will it impact both clinicians and patients with gastroesophageal carcinoma? Dr. Manish Shah: So as we have discussed throughout this podcast, the treatment for gastroesophageal cancer, both adenocarcinoma and squamous cell cancer, is increasingly complex, increasingly biomarker-driven. And I think the value of the guideline is to place all of that into context. So it provides the data for why certain biomarkers are important, what therapies should be indicated. Not only that, but if you are able to review the guideline, it provides the details of each of these studies and summarizes them in a meta-analysis fashion to sort of give you the context, because sometimes the individual studies can be maybe a little bit discordant or confusing and the guideline attempts to harmonize all that. And then also, I think the tables are very, very interesting because they give you actual numbers in terms of how many patients over a thousand would this benefit or how many patients over a thousand would this cause harm in terms of nausea, vomiting, or other things like that. So it gives you context for helping clinicians and patients weigh the potential benefits of the novel treatment strategies against the potential adverse events. And then finally, the guideline does also provide an algorithm that you are able to follow based on the biomarkers, and those are in figures 4 and 5. So I think overall, it is a very comprehensive guideline. It intends to make more manageable a very complex subject, and you know, I really encourage our listeners to review it after listening to the podcast. Dr. Lakshmi Rajdev: If I can add to that, I think that what is also really good about the guidelines is there are quick summaries. So if someone is busy in the clinic, of course, there is the opportunity to review the data supporting the guidelines in great depth in the manuscript, but what is also really good is that there are good summaries. In the event that you are very busy, you can easily identify what the recommendations should be for that particular patient based on these summaries. Brittany Harvey: Absolutely. Listeners are encouraged to review the full guideline, including those tables and figures that may be more helpful when they are looking for something quick to look at in the clinic as well. So, as you both mentioned, there have been a number of recent practice-changing trials in this area. So I imagine there is still a lot of ongoing research as well. So Dr. Shah, what are the outstanding questions regarding treatment options for patients with locally advanced unresectable, advanced, or metastatic gastroesophageal carcinoma? Dr. Manish Shah: I think we touched upon it a little bit. The guidelines are based on the data available, and they are primarily examining one novel therapy with chemotherapy in a specific biomarker population. But as you know, the biomarkers are not either/or; you are not either CLDN18.2 positive or PD-L1 positive. A portion of patients could have dual biomarkers, and you know, I think that we are generating data on how to manage those patients. At the recent GI Symposium in January this year, the ILUSTRO trial was presented by Dr. Shitara, which looked at combining zolbetuximab and chemotherapy with immunotherapy for dual-positive biomarkers, and that is leading to a phase III study that has begun to enroll. So unanswered questions are: how do we manage dual-positive biomarkers? The other thing that was mentioned is that the current data for mismatch repair deficiency involve chemotherapy plus immunotherapy. Only squamous cell cancer is there a study with a positive non-chemotherapy kind of backbone, that is CheckMate-648 that Dr. Rajdev mentioned. As we move forward, it will be good to get data on non-chemotherapy options in certain biomarker-positive populations. And then finally, another update, which is likely to be practice-changing, is the HERIZON-GEA-01 study that looked at zanidatamab, which is another biparatopic antibody that targets HER2, and that is likely to change practice. And as that data gets published, we may look to even do a rapid update for the current immunotherapy and targeted therapy guideline that is just being published. Dr. Lakshmi Rajdev: So, if I can add to that, there are numerous ADCs that look very interesting. There are bispecific antibodies; in fact, the zanidatamab is a bispecific antibody showing improved activity in patients with HER2-positive disease. So I think there are studies from Asia looking at CLDN CAR T-based therapies. So, I think that there are a lot of novel agents and a lot of excitement in the field. We know that the bemarituzumab study, unfortunately, the FGFR2 inhibitor failed to demonstrate any benefit, but I think that there are other agents that are being explored, so there are newer targets, newer agents, ADCs, bispecifics that could potentially change the field in the future. Brittany Harvey: Yes, we will look forward to the data to address these unanswered questions and new agents and inform future guideline updates. So, I would like to thank you both for all of your work to review the evidence here and update this important guideline, and for your time today, Dr. Rajdev and Dr. Shah. Dr. Lakshmi Rajdev: Thank you. Dr. Manish Shah: Thank you. Brittany Harvey: And finally, thank you to all of our listeners for tuning in to the ASCO Guidelines podcast. To read the full guideline, go to www.asco.org/gastrointestinal-cancer-guidelines. You can also find many of our guidelines and interactive resources in the free ASCO Guidelines app, which is available in the Apple App Store or the Google Play Store. If you have enjoyed what you have heard today, please rate and review the podcast and be sure to subscribe so you never miss an episode. The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement.

Are you holding yourself back from biotech roles because you don't check every box on the job description? You're not alone, and it's costing you opportunities.In this career chat, Carina sits down with Heer Shah, a Scientist in cell and gene therapy at Ensoma, a Boston-based biotech developing precision gene therapies using synthetic viral vectors and gene editing technologies. Heer has over seven years of biotech experience spanning vaccines, AAV, lentiviral vectors, VLPs, and LNPs, with roles at Merck, Intellia Therapeutics, Ring Therapeutics, and Sana Biotechnology. Heer holds a Master's in Biotechnology from Northeastern University, where the co-op program launched a career built on hands-on industry experience from day one. Today, Heer does vector engineering and gene editing optimization for programs targeting sickle cell disease and immuno-oncology.Heer shares how foundational lab skills and a big-picture mindset opened doors at every stage, and what it really takes to build a long-term biotech career across multiple modalities.Key takeaways from this episode:Why job descriptions are wish lists, not checklists, and why hiring managers value learning ability over a perfect resume matchHow to position diverse experience across biotech modalities as a competitive advantageThe difference between specialists and integrators, and why companies need bothWhat it's like surviving multiple rounds of biotech layoffs and how to build career resilienceHow the Northeastern co-op program helped Heer explore different company sizes and career paths before committingWhy behavioral interview questions often matter more than technical onesHow international scientists can navigate visa pathways, including the National Interest WaiverThe career advice Heer wishes someone gave earlier: tell your story soonerWhether you're early in your biotech journey or navigating a career transition, this conversation is packed with practical advice on building transferable skills, staying adaptable, and landing roles you're excited about.Want scripts, practice drills, and feedback from peers in biotech?Join our Biotech Career Coach Skool community: https://www.skool.com/biotech-career-coach/aboutConnect with Heer on LinkedInLearn more about the Collaboratory Career Hub community and access our free resources:Join our Skool CommunityTake the Free 7-day Interview Sprint ChallengeCheck out our sister podcast: Building BiotechsSend Carina a connection request on LinkedIn!Stay connected with us:

In this episode, Max sits down with double board-certified physician and nutrition expert Dr. Amy Shah, MD to explore how gut health influences hormones, energy, mood, and longevity, why modern life may be sabotaging our microbiome, and whether viral trends like “fartmaxxing” are helping or hurting. Grab her new book, Hormone Havoc, out now.15 Daily Steps to Lose Weight and Prevent Disease PDF: https://bit.ly/46XTn8f - Get my FREE eBook now!Subscribe to The Genius Life on YouTube! - http://youtube.com/maxlugavereWatch my new documentary Little Empty Boxes - https://www.maxlugavere.com/filmThis episode is proudly sponsored by:I sleep on an Avocado mattress because real organic materials, no synthetic shortcuts, and better breathability make a noticeable difference. Go to ⁠http://avocadogreenmattress.com/MAX⁠ to check out their mattress and bedding sale.Momentous holds its products to rigorous quality and purity standards set by the NFL and NBA. I use their creatine and protein regularly. Head to livemomentous.com/genius or use code GENIUS for 35% off your first subscription.Shopify makes it easy to accept payments, manage orders, and build relationships with customers (cha-ching!). Get everything you need to sell in person and online at http://shopify.com/genius and get a one-dollar-per-month trial period!

In this episode of Keeping it Real, we sit down with world-renowned plastic surgeon and human rights activist Dr. Sheila Nazarian. Before the success and the Beverly Hills practice, she was a six-year-old Jewish refugee fleeing the 1979 Islamic Revolution in Iran. Dr. Nazarian shares the terrifying reality of her family's escape—smuggled through the desert in the back of a truck under burlap sacks, taking fire from Iranian border police just to survive. We pull back the curtain on the "Red-Green Alliance"—the historic and deadly partnership between communists and Islamists that overthrew the Shah—and why Dr. Nazarian sees that exact same playbook unfolding on American college campuses today. From dissecting the hypocrisy of modern political movements to the reality of the current uprisings in Iran, this is an unfiltered look at what it actually takes to protect freedom. What We Cover: The brutal reality of Dr. Nazarian's family fleeing the 1979 Islamic Revolution.+1 How the "Red-Green Alliance" of communists and Islamists historically dismantled Iran.+1 The dangerous parallels between 1979 Iran and modern American college protests. The critical difference between true asylum seekers and economic migrants. Why the current protests in Iran could fundamentally reshape the Middle East and why a nuclear Iran is a global threat. Shopify: Launch your dream business with Shopify. Sign up for your $1/month trial at https://Shopify.com/Jillian and start selling today! 120Life: Go to https://120Life.com and use code JILLIAN to save 20% Cozy Earth: Visit https://www.CozyEarth.com/MICHAELS & Use code MICHAELS for up to 20% off Learn more about your ad choices. Visit megaphone.fm/adchoices

Noble Investment Group Founder and CEO Mit Shah has put his money where his mouth is in terms of investing in extended-stay hotels, and he lays out why he's a big believer in the evolution of "branded long-term accommodations." 

We're diving into the hormonal chaos no one prepared us for… with Dr. Amy Shah, double board certified physician, nutrition specialist and author of Hormone Havoc. Dr. Shah breaks down the hormonal continuum, why getting rid of toxic people in your life is good for your gut and shares real tools for feeling power-FULL instead of powerless. Follow the "I Choose Me" Podcast on Instagram and TikTok Follow Jennie on Instagram, TikTok, and FacebookSee omnystudio.com/listener for privacy information.

The surgeon who spent 12 to14 hours a day in the operating room developed diabetes, uncontrolled high blood pressure, and an autoimmune disease that was eating away at his skull and it forced him to confront what medical school never taught him about actually staying healthy. I sat down with Dr. Darshan Shah, board-certified surgeon, founder of Next Health (one of the largest longevity clinic networks in America), and a doctor who had to reverse his own chronic disease to understand the massive gap between Western medicine and the science of health. We explore why surgeons and physicians become some of the sickest people in healthcare, how functional medicine differs from what you learn in medical school, why biomarker testing matters more than your doctor's "you're fine" assessment, and what root cause medicine actually looks like in practice. Dr. Shah also breaks down the AI revolution happening in cardiovascular imaging with Cleerly scans, how his new AI health dashboard reads your bloodwork and medical records to give you proactive guidance, why Yamanaka factors could regenerate damaged nerves in the brain, and what the future of personalized, preventive medicine looks like when you combine AI with real biological data. Reduce your risk of Alzheimer's with my science-backed protocol for women 30+: https://go.neuroathletics.com.au/youtube-sales-page Subscribe to The Neuro Experience for evidence-based conversations at the intersection of brain science, longevity, and performance. _____ TOPICS DISCUSSED 00:00 Intro: The surgeon who developed the diseases he was treating 01:17 From trauma surgeon to longevity doctor: Dr. Shah's journey 04:18 Autoimmune disease, diabetes, and high blood pressure in a surgeon 10:30 Western medicine vs. the science of health 18:45 Why doctors don't learn prevention in medical school 35:20 Next Health clinics and democratizing longevity medicine 52:40 Biomarker testing and why "your labs are normal" is dangerous 01:03:52 AI health dashboard: uploading bloodwork and getting proactive guidance 01:06:45 Cleerly scans and reversing cardiovascular disease with AI imaging 01:10:08 Yamanaka factors, nerve regeneration, and the future of brain health _______ Thank you to our sponsors Function Health: https://www.functionhealth.com/louisanicola Timeline Mitopure: http://timeline.com/NEURO Ka'Chava: https://kachava.com and use code NEURO for 15% off your first order Wayfair: https://www.wayfair.com/ Fenix: https://www.fenixhealthscience.com/ Arey: https://arey.com/ and use code NEURO _______ I'm Louisa Nicola - clinical neurophysiologist - Alzheimer's prevention specialist - founder of Neuro Athletics. My mission is to translate cutting-edge neuroscience into actionable strategies for cognitive longevity, peak performance, and brain disease prevention. If you're committed to optimizing your brain- reducing Alzheimer's risk - and staying mentally sharp for life, you're in the right place. Stay sharp. Stay informed. Join thousands who subscribe to the Neuro Athletics Newsletter → https://bit.ly/3ewI5P0 Instagram: https://www.instagram.com/louisanicola_/ Twitter : https://twitter.com/louisanicola_ Learn more about your ad choices. Visit megaphone.fm/adchoices

Guest: Joshua A. Shah, MS, CCC-SLPEarn 0.10 ASHA CEUs for this episode: Complete the accompanying course online with Speech Therapy PDWatch this episode on Youtube: Initiation with Filmmaker and SLP Joshua ShahIn a First Bite first, host Michelle Dawson, MS, CCC-SLP, CLC, BCS-S, sits down with Joshua A. Shah, MS, CCC-SLP, a speech-language pathologist, filmmaker, and the creative force behind the upcoming film Initiation, a fictional narrative inspired by lived experiences related to stuttering and communication differences. Joshua and Michelle explore the responsibilities that come with representing communication differences accurately and compassionately and how language, storytelling, and visibility shape public understanding. Together, they examine the connection between communication and power, including how representation can influence whose voices are valued, amplified, or marginalized. Tune in now for a thoughtful, timely conversation, and stay tuned for the film that sparked it.About the Guest(s): Joshua A. Shah is a filmmaker from Fremont, California. He currently serves as a home health speech-language pathologist, primarily working with individuals with neurological and communication impairments. He's become inspired to bring the narratives of individuals with communication challenges to the silver screen and is dedicated to crafting these stories with both accuracy and creativity, challenging the current media landscape with empathetic storytelling.Show Notes:Contact Joshua: @shahjosh on InstagramLove Money Cause: @initiationshortfilm on Instagram“Initiation” Short Film: seedandspark.com/fund/initiation2026#storyThe Stuttering Foundation: www.stutteringhelp.orgSPACE | Stuttering Organization: www.spacetostutter.org and @spacetostutter on InstagramThe Man Who Mistook His Wife for a Hat: www.oliversacks.com/oliver-sacks-books/the-man-who-mistook-his-wife-for-a-hat/My Stroke of Insight: mystrokeofinsight.com/index.htmlThe Sound of Metal: www.imdb.com/title/tt5363618/American Association for People with Disabilities: www.aapd.comAble South Carolina: www.able-sc.orgFirst Bite Podcast: Subscribe and listen on Spotify or Apple Podcast

Why do so many women feel exhausted, dismissed, or confused about their health? Why are painful periods, chronic fatigue, and burnout so often labeled “normal”? And how did women’s hormones go so long without being properly studied? In this episode of A Really Good Cry, Radhi sits down with integrative medicine doctor and hormone expert Dr. Amy Shah for an honest, grounding conversation about women’s hormones, stress, and the gaps in modern healthcare. Together, they explore why so many women struggle to get real answers, how stress and cortisol quietly shape our health, and what it actually means to support hormones in a sustainable way. From period pain and hormone testing to gut health, nutrition, perimenopause, and burnout, this episode breaks down complex science into language that feels accessible, validating, and empowering. Dr. Shah shares why there is no single “magic fix” for hormone balance—and why listening to your body, supporting your nervous system, and nourishing your gut can make a meaningful difference over time. In this episode, you’ll learn: Why many hormone tests don’t reflect what women are actually experiencing Which symptoms women are taught to ignore—but shouldn’t How stress and cortisol affect women differently than men Why gut health and nutrition play a major role in hormone balance What actually helps support hormones without extreme diets or trends This conversation isn’t about quick fixes or perfection—it’s about understanding your body, questioning what you’ve been taught to tolerate, and learning how to support your health with more awareness and compassion. Follow Dr. Amy Shah: https://amymdwellness.com/ https://www.youtube.com/@dramyshah/ https://www.instagram.com/dramyshah/ https://www.linkedin.com/in/amyshahmd/ https://www.facebook.com/amyshahmd Follow Radhi: https://www.instagram.com/radhidevlukia/ https://www.youtube.com/channel/UCxWe9A4kMf9V_AHOXkGhCzQ https://www.facebook.com/radhidevlukia1/ https://www.tiktok.com/@radhidevlukiaSee omnystudio.com/listener for privacy information.

Artificial intelligence (AI) is exerting a profound influence on the domain of plastic surgery, shaping experiences for both patients and practitioners alike. It's now an omnipresent force across a multitude of sectors, so of course, plastic surgery, too!Carefully discerning when AI produces substantial benefits and when it may introduce unforeseen complexities is important. How, then, can we navigate these nuanced distinctions? In this episode of the podcast, facial plastic surgeon Dr. Anil Shah in Chicago/New York offers his informed perspective and firsthand observations on the evolving role of AI within the field of plastic surgery.Tune in!

We're diving into the hormonal chaos no one prepared us for… with Dr. Amy Shah, double board certified physician, nutrition specialist and author of Hormone Havoc. Dr. Shah breaks down the hormonal continuum, why getting rid of toxic people in your life is good for your gut and shares real tools for feeling power-FULL instead of powerless. Follow the "I Choose Me" Podcast on Instagram and TikTok Follow Jennie on Instagram, TikTok, and FacebookSee omnystudio.com/listener for privacy information.

This week, Jack Sharry talks with Sneha Shah, Executive Vice President and Head of New Business Ventures at SEI. Sneha brings more than 25 years of global leadership experience across data, technology, and human-centered innovation.  Jack and Sneha explore how innovation actually takes root inside large financial services organizations. Sneha shares how SEI is incubating new ideas, empowering employees, and turning emerging technologies like AI and tokenization into real-world impact. The conversation spans mindset shifts, the role of community, generational and gender-based wealth transfer, and why partnerships—not ownership—will determine who wins in the next era of wealth management. In this episode: (00:00) - Intro (01:35) - Sneha's global career journey and her role at SEI (04:47) - How SEI sources ideas and turns them into new ventures (07:39) - From idea to impact: real examples of innovation getting funded (09:45) - How employees are responding to SEI's innovation culture (10:40) - Why personalized communication is key to leading organizational change (14:46) - Sneha's outlook on the future of the financial services industry (19:18) - Why partnerships matter more than ever in times of rapid change (21:05) - Sneha's key takeaways (22:08) - Sneha's interests outside of work Quotes "The largest obstacle to the emerging technologies is not the technology itself—it's often the mindset that will allow that technology to take root." ~ Sneha Shah "Innovation cannot be impactful unless you actually bring people along. And I see that with AI and tokenization. The use, adoption, and scaling of it really depend on the human being feeling like it's something that's going to help transform that job." ~ Sneha Shah "The failure of our ability to take advantage of technology is not going to be technology. It's going to be our lack of imagination. And so the more that you can excite people's imagination and get them to engage, the further you can really take these technologies." ~ Sneha Shah Links  Sneha Shah on LinkedIn SEI SEI Next Thomson Reuters Education Development Center African Leadership Academy Connect with our hosts LifeYield Jack Sharry on LinkedIn Jack Sharry on Twitter Subscribe and stay in touch Apple Podcasts Spotify LinkedIn Twitter Facebook

Get Dr. Vonda's latest insights on strength, bone health, longevity, and aging with power delivered straight to your inbox. Join her free health & longevity newsletter here: https://www.drvondawright.com/resources/aging-longevity   For years, we've focused on the external markers of health, but I've become increasingly obsessed with the internal landscape, specifically, how the food we eat communicates with our biology. We used to view nutrition as just calories in and calories out, but we now know it's a sophisticated signaling system that dictates our hormones, our mood, and even how we age. If you've felt like you're doing "everything right" but still feel exhausted or out of balance, the missing piece isn't your effort; it's likely the lack of foundational support for your internal "Amazon jungle", your gut microbiome.   In this episode, I sit down with the brilliant Dr. Amy Shah to discuss her new book, Hormone Havoc, and the simple yet profound framework she's developed to help women reclaim their vitality. We explore how moving away from restrictive diets and toward a science-backed "30-30-3" rule can stabilize your hormones, lower systemic inflammation by nearly 20%, and finally give your body the fuel it needs to thrive through perimenopause and beyond.   What we explore: - How the "30-30-3" framework simplifies nutrition for busy women by focusing on protein, fiber, and fermented foods. - Why eating 30 grams of protein in your first meal is a non-negotiable for mental focus and managing midlife cravings. - Why fermented foods like sauerkraut and yogurt act as a "walkie-talkie" to signal your immune system and lower inflammation. - How a daily goal of 30 grams of fiber can lower mortality by up to 10% by feeding your beneficial gut bacteria. - The critical role of the "estrobolome", gut bacteria that specifically regulate how estrogen is processed in your body. - Why modern medicine often overlooks practical nutrition training and why you must be your own advocate. - How simple "hacks" like adding chia seeds or raspberries can rapidly close your daily fiber gap. - What science says about the power of "postbiotics" found in traditional foods like sourdough bread.   About the Dr. Amy Shah: Dr. Amy Shah is a double board-certified medical doctor and nutrition expert who has taken the digital world by storm with her mission to help women feel less "effing tired". Through her clinical work and best-selling books, she bridges the gap between complex medical science and practical, everyday nutrition that fits into the busy lives of modern women.   Connect with Dr. Amy Shah: Instagram: https://www.instagram.com/dramyshah Website: https://amymdwellness.com/   Timestamps (placeholder)   00:00 Intro 05:40 The "criminal" lack of nutrition education in traditional medical training. 07:15 Breaking down the 30-33 Framework: Protein, Fiber, and Fermented Foods. 10:42 The Internal Amazon Jungle: How gut bacteria communicate with your brain. 14:15 Secrets of Longevity: Why the world's oldest woman ate yogurt three times a day. 18:40 Understanding the Estrobolome: The gut-hormone connection you need to know. 21:05 Fiber Hacks: How raspberries and chia seeds can lower your mortality risk. 24:30 The Protein Breakfast Rule: Why 30 grams at your first meal changes your entire day. 35:15 Practical fermented food swaps for those who don't like kimchi. 46:30 Why your best years and your best work are still ahead of you.  

"What happens when a nation fears its own people more than its enemies?" In this gripping episode of Kent Hance, The Best Storyteller in Texas, Kent opens with a powerful reflection on the timeless saying: "War is hell." From the ongoing turmoil between Russia and Ukraine to rising tensions in Iran, Kent unpacks the complex history and real-time consequences of global conflict — all with his trademark clarity, depth, and unmistakable Texas storytelling.

In this episode, I'm talking to Dr. Nirali Shah Jain, a fertility specialist and researcher who's making waves both in the clinic and on social media as @eggspert_md. Dr. Jain brings a refreshing blend of evidence-based medicine and genuine compassion to the often overwhelming world of IVF. We dive deep into her groundbreaking research on PGT-A testing in donor egg cycles, published in Fertility and Sterility, and discuss what it really means for patients making decisions about embryo testing. Her unique background as a trained dancer in Indian classical, modern, and ballet gives her a disciplined yet creative approach to patient care that truly sets her apart. Read the full show notes on Dr. Aimee's website. In this episode, we cover: Dr. Jain's research on PGT-A testing in donor egg IVF and when genetic testing is truly beneficial The difference between embryo grading and chromosomal health—and why they're not the same thing Fresh versus frozen embryo transfers: which approach makes sense for different patient scenarios Fertility-friendly nutrition, including the Mediterranean diet and the truth about alcohol during treatment Managing IVF side effects, bloating, and stress with practical, accessible strategies Debunking the myth that egg freezing depletes your future fertility Fertility preservation for cancer patients and the importance of pre-treatment counseling Resources: Follow Dr. Nirali Shah Jain on Instagram: @eggspertMD Dr. Jain's research: Fertility and Sterility journal (donor egg IVF and PGT-A study) Where to Find Dr. Jain: RMA New Jersey Follow Dr. Aimee on Instagram, YouTube, and TikTok Listen to The Egg Whisperer Show on Spotify   Do you have questions about IVF, and what to expect? Click here to join Dr. Aimee for The IVF Class. The next live class call is on Monday, March 9th, 2026 at 4pm PST, where Dr. Aimee will explain IVF and there will be time to ask her your questions live on Zoom. Click to find The Egg Whisperer Show podcast on your favorite podcasting app.   Watch videos of Dr. Aimee answer Ask the Egg Whisperer Questions on YouTube.  Sign up for The Egg Whisperer newsletter to get updates  Dr. Aimee Eyvazzadeh is one of America's most well known fertility doctors. Her success rate at baby-making is what gives future parents hope when all hope is lost. She pioneered the TUSHY Method and BALLS Method to decrease your time to pregnancy. Learn more about the TUSHY Method and find a wealth of fertility resources at www.draimee.org.  Keywords: IVF, PGT-A testing, donor egg IVF, embryo grading, embryo testing, fertility preservation, egg freezing, cancer and fertility, Mediterranean diet for fertility, IVF side effects, fresh vs frozen embryo transfer, fertility doctor, reproductive endocrinology, egg quality, fertility nutrition, IVF stress management, fertility myths, chromosomal testing, donor eggs, fertility research, women's health, fertility treatment, infertility, assisted reproduction, embryo quality, fertility specialist, Dr. Nirali Shah Jain, Dr. Aimee Eyvazzadeh

durée : 00:11:25 - Le Fil de l'histoire - par : Stéphanie Duncan - En 1979, le shah d'Iran fuyait le pays pour finalement se réfugier aux Etats-Unis, ce pays qui l'avait soutenu presque jusqu'au bout. Simultanément, un autre homme fort, charismatique et habile, apparaissait et allait bientôt prendre la tête de la révolution iranienne : l'ayatollah Khomeiny... - invités : Bernard HOURCADE - Bernard Hourcade : Géographe, directeur de recherche émérite au CNRS et membre du comité de rédaction de la revue "Orient XXI" - réalisé par : Claire DESTACAMP Vous aimez ce podcast ? Pour écouter tous les autres épisodes sans limite, rendez-vous sur Radio France.

Good Morning, Coming down from Yorkshire to London I usually walk through Marchmont Street. I often stop and look up at a Blue Plaque over a shop that was once a hairdressers. It's where Kenneth Williams spent the first part of his life. I worked with him in the late 1970's when I was a young producer with a missionary society. We were looking at new ways of getting the Christian faith to resonate with young people. I'd heard somewhere that the Ayatollah Khomeini, then exiled in Paris, was flooding Iran with messages on audio cassettes to topple the Shah. It may seem quite a leap but it prompted me to wonder if we too could use cassettes to reach out to the next generation. So we hired four famous comedians to retell the life and parables of Jesus . Soon we were in the studio with Derek Nimmo, Dora Bryan, Thora Hird and - Kenneth Williams recording a sparkling script by Jenny Robertson. Yesterday marked the Centenary of Kenneth Williams' birth – one of Radio 4's famous voices who knew the power of comedy to shock, to scandalise and to deflate the pompous. But he was also a sensitive man who prayed at the end of each day out of the depths of his own tortured soul. He excelled in recording these cassettes and captured the way Jesus himself used stories to cut the powerful down to size, especially religious ones. One of Jesus' amusing stories was told against the hypocrisy of the judgmental - of two men, one with a plank shooting out of his eye trying to pick a spec out of the other's – a comic sketch worthy of Basil Fawlty berating a hapless hotel guest! The paradox of humour is that comedy can pack a serious punch which is why the powerful, especially dictators hate being made fun of. Nor can they tolerate the freedom the media give to voice such protest. 50 years on, Iran's latest Ayatollah, while recognising the role media played in bringing them to power , now appears to be tightly controlling the internet, in what is widely seen as an attempt to stem the flow of information about a government crackdown on protesters. Memories of Kenneth Williams today make me nostalgic for a more spacious world where the freedom to speak out and even to make fun of each other were the signs of safer times. Kenneth Williams – rest in peace and in the memory of our laughter.

For more than a decade, the debate around PGT has felt like the same arguments, the same uncertainty, and little change in day-to-day clinical decision-making.So what's different now?Joining the conversation are two REIs, Dr. Deirdre Conway of Utah Fertility Center and Dr. Meera Shah of Nova IVF. Together they examine how recent events, emerging data, and evolving lab practices are reshaping how physicians think about PGT.They discuss:What has changed since the late-2024 class action lawsuit against PGT labsHow practices and networks are evaluating PGT lab partnerships todayWhy IVY Fertility has not yet selected a single PGT labWhat additional evidence clinicians want to see around PGT-A and PGT-GWhich PGT lab stood out to Dr. Conway (And the story behind her first case)This is a grounded, clinician-led conversation about evidence, accountability, and what it would actually take for the PGT debate to move forward.

EPISODE SUMMARY In this episode, Arundhati Parmar interviews Shalin Shah, CEO of Marius Pharmaceuticals, about Testosterone Replacement Therapy (TRT) and the long-standing regulatory classification that places testosterone as a Schedule III controlled substance. Shah explains that testosterone was scheduled in 1990 following Olympic doping scandals — despite opposition at the time from the FDA, DEA, and the American Medical Association. More than 30 years later, he argues that the regulatory framework no longer reflects current clinical evidence and may be doing more harm than good. The conversation explores: The scientific evidence surrounding cardiovascular and prostate safety The differences between injectable and oral testosterone therapies The stigma and logistical barriers created by controlled substance status How GLP-1 drugs intersect with hormone health and muscle preservation The possibility of expanding testosterone therapy access to women Whether the current regulatory environment may revisit testosterone scheduling At its core, this episode examines whether testosterone is being regulated based on outdated controversy rather than modern clinical science — and what that means for patients navigating care today. Episode Resources Connect with Arundhati Parmar aparmar@medcitynews.com  https://twitter.com/aparmarbb?lang=en https://medcitynews.com/ KEYWORDS Testosterone Replacement Therapy TRT regulation Schedule III classification Controlled substances Hormone therapy stigma Men's health Women's hormone therapy TRAVERSE study Cardiovascular risk Prostate cancer risk Oral testosterone Injectable testosterone Hematocrit levels GLP-1 muscle loss Hypogonadism FDA regulation Healthcare policy Hormone optimization   EPISODE HIGHLIGHTS 00:00–01:40 - Why testosterone became a Schedule III controlled substance in 1990 01:40–02:30 - Political backlash after Olympic doping scandals 02:30–03:56 - Testosterone as the only controlled hormone 03:56–04:58 - The physiologic role of testosterone across multiple organ systems 04:58–06:19 - Cardiovascular and prostate cancer risk: What the TRAVERSE study showed 06:19–07:04 - Physiologic vs. supraphysiologic dosing 07:04–08:49 - How controlled status creates stigma and access barriers 08:49–10:10 - Provider tracking, pharmacy hurdles, and patient friction 10:10–11:48 - Would deregulation increase abuse or doping? 11:48–13:20 - GLP-1 drugs, rapid weight loss, and muscle preservation 13:20–15:08 - Testosterone in women: The overlooked half of the population 15:08–16:22 - Injectable vs oral TRT: Mimicking natural diurnal rhythms 16:22–17:40 - Hematocrit elevation differences between injections and oral therapy 17:40–19:07 - Side effect profiles and hormone signaling differences 19:07–20:32 - Go-to-market strategy: Cash pay vs insurance coverage 20:32–21:24 - Stigma among payers and barriers to reimbursement 21:24–22:43 - Expanding label indications and idiopathic hypogonadism 22:43–22:22 - Could the current administration reconsider testosterone scheduling?  

Mark's guest Dr. Maully Shah from CHOP goes into the causes and treatments for Cardiac Arrhythmia and the exciting future of treatment and diagnosis.

Kavita Shah is an Indian-American award-winning vocalist, composer and polyglot. She's been hailed by NPR for possessing an “amazing dexterity for musical languages”. Her music covers modern jazz, new music, and her own exploration of folk traditions from Brazil to West Africa to India. Her album “Interplay” was nominated for France's Victoire de la Musique for Jazz Album of the Year. She regularly performs at major concert halls, festivals, and clubs on six continents. And she started a record label called Folkalist to focus on female voices of the Global South.My featured song is “Feeling So Good” from the album Bobby M and the Paisley Parade. Spotify link.—-----------------------------------------------------------The Follow Your Dream Podcast:Top 1% of all podcasts with Listeners in 200 countries!Click here for All Episodes Click here for Guest List Click here for Guest Groupings Click here for Guest TestimonialsClick here to Subscribe Click here to receive our Email UpdatesClick here to Rate and Review the podcast—----------------------------------------CONNECT WITH KAVITA:www.kavitashahmusic.com—----------------------------------------ROBERT'S LATEST RELEASE:“MA PETITE FLEUR STRING QUARTET” is Robert's latest release. It transforms his jazz ballad into a lush classical string quartet piece. Praised by a host of classical music stars.CLICK HERE FOR YOUTUBE LINKCLICK HERE FOR ALL LINKS—---------------------------------------ROBERT'S RECENT SINGLE“MI CACHIMBER” is Robert's recent single. It's Robert's tribute to his father who played the trumpet and loved Latin music.. Featuring world class guest artists Benny Benack III and Dave Smith on flugelhornCLICK HERE FOR YOUTUBE LINKCLICK HERE FOR ALL LINKS—--------------------------------------ROBERT'S LATEST ALBUM:“WHAT'S UP!” is Robert's latest compilation album. Featuring 10 of his recent singles including all the ones listed below. Instrumentals and vocals. Jazz, Rock, Pop and Fusion. “My best work so far. (Robert)”CLICK HERE FOR THE OFFICIAL VIDEOCLICK HERE FOR ALL LINKS—----------------------------------------Audio production:Jimmy RavenscroftKymera Films Connect with the Follow Your Dream Podcast:Website - www.followyourdreampodcast.comEmail Robert - robert@followyourdreampodcast.com Follow Robert's band, Project Grand Slam, and his music:Website - www.projectgrandslam.comYouTubeSpotify MusicApple MusicEmail - pgs@projectgrandslam.com  

Chas & Dr Dave discuss Four Drinks in 27 Minutes, The Biggest Liar No Longer in the Government and The War on Anything WARNING: This episode of PEP may contain explicit language.   Timestamps: 0:00 - Introducing: Dr Dave 3:01 - Correspondence (Police Shootings, Sleep, Epstein) 22:13 - Grateful (Jesse Jackson) 43:34 - Grateful (Seditious 6) 54:17 - Economy (Unemployment, Inflation, Polling, Warsh) 1:32:22 - Tangent Treehouse - (AI Stuff) 1:44:34 - Immigration (The Good News, ICE Wilding, Detention)  2:20:16 - Canada Bridge 2:38:30 - DHS Shutdown 2:50:40 - Unleashed (DHS Proposed Reforms)   SHOW LINKS: *Chat with the PEPpers on the Discord Server: https://discord.com/invite/WxDD2PPvaW     Homework: Melinda Cooper Epstein article -  https://bitly.cx/O0iJ Jesse Jackson Wattstax festival - https://bitly.cx/HXAsx   THE (UPDATED) DR DAVE BOOK CLUB MASTERLIST: Connie Willis - Doomsday Book & To Say Nothing of the Dog (Mentioned 4:26, Ep 244) Richard Yates - Revolutionary Road  (Mentioned 1:48:45, Ep 240) Michael Lewis - Who Is Government? (Mentioned 2:19:59, Ep 235) Orlando Whitfield - All That Glitters (Mentioned 2:34:37, Ep 232) John Lyons - Balcony Over Jerusalem (Mentioned 2:45:26, Ep 231) Yukio Mishima - Spring Snow (Mentioned 2:35:12, Ep 227) John Steinbeck - Cannery Row (Mentioned 02:39, Ep 226) David Simon & Ed Burns - The Corner: A Year in the Life of an Inner-City Neighborhood (Mentioned 2:21:40, Ep 225) William Appleman Williams - The Tragedy of American Diplomacy (Mentioned 2:11:23, Ep 222) Mahmood Mamdani - Good Muslim, Bad Muslim (Mentioned 2:07:14, Ep 220) Carlo Rovelli - The Order Of Time (Mentioned 06:36, Ep 220) Carlo Rovelli - Reality Is Not What It Seems (Mentioned 06:36, Ep 220) Ryszard Kapuściński - Shah of Shahs (Mentioned 2:21:27, Ep 217) Ervand Abrahamian - Khomeinism (Mentioned 2:23:19, Ep 217) Anthony Seldon - Truss at 10 (Mentioned 1:36:09, Ep 215) Steven Teles - The Conservative Legal Movement (Mentioned 2:12:12, Ep 215) Amin Maalouf - The Crusades Through Arab Eyes (Mentioned 4:32, Ep 214) Geoffrey Blainey - The Causes Of War (Mentioned 43:49, Ep 198) Margaret Levi - Of Rule And Revenue (Mentioned 1:11:16, Ep 195) Margaret Levi - Consent, Dissent, and Patriotism (Mentioned 1:11:16, Ep 195) Sayaka Murata - Convenience Store Woman (Mentioned 2:14, Ep 194) Sid Meier - Sid Meier's Memoir! (Mentioned 16:30, Ep 178) David Simon & Ed Burns - The Corner (Mentioned 8:40, Ep 178) Maurice O. Wallace - King's Vibrato (Mentioned 14:26, Ep 164) Edward S. Herman and Noam Chomsky - Manufacturing Consent - (Mentioned 32:12, Ep 164) Robert Plunket - My Search For Warren Harding (Mentioned 1:49:12, Ep 158) Ian Lambot & Greg Girard - City of Darkness Revisited (Mentioned 39:25, Ep 157) Max Chafkin - The Contrarian (Mentioned 32:18, Ep 155) Claire Conner - Wrapped In The Flag (Mentioned 31:42, Ep 155) Rita Abrahamsen, Mike Williams et al - Global Right (Mentioned 31:12, Ep 155) Philip Gorski and Samuel Perry - The Flag And The Cross (Mentioned 30:49, Ep 155) Cynthia Miller-Idriss - Hate In The Homeland (Mentioned 30:10, Ep 155) Cory Doctorow & Rebecca Giblin - Chokepoint Capitalism (Mentioned 34:55, Ep 150) Elizabeth Ingleson - Made In China (Mentioned 31:50, Ep 150) John Corrigan - Religious Intolerance, America, and the World (Mentioned 1:16:18, Ep 141) Gérard Prunier - From Genocide to Continental War (Mentioned 48:18, Ep 141) Liu Cixin, - The Three Body Trilogy (Mentioned 1:11:04, Ep 136) Tilman Allert - The Hitler Salute (Mentioned 22:03, Ep 134) Philip Roth - Nemesis (Mentioned 1:56, Ep 133) Joshua Cohen - The Netanyahus Zeke Faux - Number Go Up Michael Paul Rogin - The Intellectuals and McCarthy Cathy Kramer - The Politics of Resentment Naomi Klein - Doppelganger Maria Bamford - Sure, I'll Join Your Cult Wendy Brown - States Of Injury Corey Robin. - The Reactionary Mind Patricia Lockwood - No One Is Talking About This David Cay Johnston - The Making of Donald Trump Jane Mayer - Dark Money Harry Frankfurt - On Bullshit Stephen King - The Dead Zone Elle Hardy - Beyond Belief Federico Finchelstein - From Fascism to Populism in History Robert Jervis - Why Intelligence Fails Alex Haley and Malcolm X - The Autobiography of Malcolm X Jonathan Haidt - The Righteous Mind David Graeber - Debt: The First 5000 Years Jerry L. Mashaw - Creating The American Administrative Constitution Brian Balogh - A Government Out of Sight Paul Connerton - How Societies Remember Paul Connerton - How Modernity Forgets Catherine Green and Sarah Catherine Gilbert - Vaxxers John Zaller - The Nature and Origins of Mass Opinion Matthew Karp - This Vast Southern Empire Robert Fatton - The Guise of Exceptionalism Anatol Lievin - Climate Change and the Nation State: The Realist Case James Alfred Aho - The Politics of Righteousness The substack that Dr Dave apparently plagiarises liberally from! https://luke.substack.com/ James Beverley - God's Man in the White House Jane Chi Hyun Park - Yellow Future Matthias Gardell - In The Name of Elijah Muhammad Gosta Esping-Andersen - The Three Worlds of Welfare Capitalism Suzanne Mettler - The Submerged State Brendon O'Connor - Anti-Americanism and American Exceptionalism James Morone - Hellfire Nation Nathan Kalmoe - With Ballots and Bullets Winnifred Fallers Sullivan - The Impossibility of Religious Freedom Mary L. Trump - Too Much And Never Enough Richard Cooke - Tired of Winning Jon Ronson - So You've Been Publicly Shamed Rodney Tiffen, Ross Gittins, Anika Gauja, David Smith, Brendon O'Connor - How America Compares Tony Horwitz - Confederates In the Attic Ghassan Hage - White Nation George Lakoff - Women, Fire and Dangerous Things George Lakoff - Metaphors We Live By Michelle Alexander - The New Jim Crow Alex S. Vitale - The End of Policing Dave Cullen - Parkland: Birth of a Movement Thomas Sugrue - The Origins of the Urban Crisis Rick Pearlstein - The Invisible Bridge Rick Pearlstein - Before the Storm Rick Pearlstein - Nixonland Brian Doherty - Radicals for Capitalism Leon Festinger, Henry W. Riecken, Stanley Schachter - When Prophecy Fails Nancy L. Rosenblum & Russell Muirhead - A Lot Of People Are Saying Benjamin Moffitt - The Global Rise of Populism Jon Krakauer - Missoula THANK YOU FOR YOUR ATTENTION TO THIS MATTER!  

This episode is unique and timely. Shah Ahmadi was born and raised in Iran in a devout Muslim family, under a system where Islam functions as state law, not just personal faith.He grew up memorizing the Quran for hours at a time. Believing his good deeds had to outweigh his bad. Never hearing the word grace.As he began questioning and searching for truth, anxiety followed him. Fear of punishment. Spiritual resistance when he stepped toward church.Then he encountered Jesus not as an idea, but as peace .His decision cost him. His family faced arrest. And still he says, “I love Muslims. I would die for them.”This conversation is about truth, compassion, and courage. It gives insight into the climate of Iran and other Middle Eastern countries right now. Listen with an open heart. Tune into the premiere tonight at 7:30PM on the Rich Wilkerson Jr. YouTube Channel

In this episode of the Market Maker Podcast, Shah Malik shares a masterclass in how to stand out and succeed in finance, regardless of your starting point.Currently finishing his degree at King's College London and set to join Deutsche Bank full-time, Shah walks through how he broke into investment banking by focusing on execution, networking, and a relentless mindset.From turning retail jobs into winning talking points, to mastering online tests, to building meaningful relationships with senior bankers, this conversation is packed with tactical insights that go way beyond the typical “just network more” advice.Whether you're targeting spring weeks, summer internships, or full-time roles, Shah's framework for preparation, performance, and progression is one you'll want to take notes on.(00:00) Intro – Who is Shah Malik?(01:13) Growing Up Far from Finance(03:30) Discovering Finance Early(06:32) Exploring Banking, FinTech & Consulting(08:09) Mastering the Application Process(10:05) Cracking Online Tests(11:47) How to Convert Internships(14:41) Standing Out in Spring & Summer(16:11) Smart Networking (Without Overstepping)(21:36) Turning Retail Jobs Into Resume Assets(22:54) Linking Customer Service to IB Skills(25:17) Staying Ahead: Habits & Learning(27:02) Dealing with Imposter Syndrome(29:52) Building the Wize Foundation(32:51) Focus on What You Can ControlFind out more about the Wize Foundation

In this episode of Parallax, Dr Ankur Kalra welcomes Dr Rakesh Shah, a former interventional cardiologist, Oxford MBA graduate, and founder of DRS.LINQ. Dr Shah brings a unique perspective on addressing critical delays in heart attack diagnosis through the intersection of clinical medicine, engineering, and business strategy. The conversation explores a pressing challenge in cardiovascular care: the majority of cardiac damage occurs within the first hour of symptom onset, yet treatment activation often takes several hours. Dr Shah introduces mHeart, a mobile EKG platform designed to create a "virtual cardiology office." Unlike consumer wearables that lack critical chest leads, this technology enables patients to initiate comprehensive cardiac evaluation anywhere—at home, at work, or while traveling—transmitting diagnostic-quality data directly to cardiologists. The episode delves into Dr Shah's diverse career path and offers candid advice for physician-entrepreneurs, emphasizing the importance of collaboration with professional business leaders to achieve scalability. Looking ahead, Dr Shah discusses the integration of AI and machine learning into mobile diagnostic platforms as essential tools for an aging workforce and overstretched healthcare system. Questions and comments can be sent to "podcast@radcliffe-group.com" and may be answered by Ankur in the next episode. Host: @AnkurKalraMD and produced by: @RadcliffeCardio Parallax is Ranked in the Top 100 Health Science Podcasts (#48) by Million Podcasts.

Chas and Melina Wicks discuss Kid Rock's Wide Margin For Error, Lutnicking And THE DOW IS AT 50,000!!! WARNING: This episode of PEP may contain explicit language.   Timestamps: 0:00 Introducing: Guest PEPCaster Melina Wicks 2:07 - Grateful (Good Journalism, Kid Rock) 14:34 - Correspondence (Music List) 18:40 - The Fulton County Elections Office Raid 56:57 - Nationalising Elections 1:22:19 - Epstein Files (The Main Players) 2:24:49 - General Epstein Findings 2:43:25 - Unleashed (More Epstein Stuff) 3:12:04 - Unleashed (Bondi Hearing)   SHOW LINKS: *Chat with the PEPpers on the Discord Server: https://discord.com/invite/WxDD2PPvaW   Homework: Wings of Pegasus Kid Rock - https://bitly.cx/2X6E Melina's Atlantic Story Fall of Assad - https://bitly.cx/4s7Iy   THE (UPDATED) DR DAVE BOOK CLUB MASTERLIST: Connie Willis - Doomsday Book & To Say Nothing of the Dog (Mentioned 4:26, Ep 244) Richard Yates - Revolutionary Road  (Mentioned 1:48:45, Ep 240) Michael Lewis - Who Is Government? (Mentioned 2:19:59, Ep 235) Orlando Whitfield - All That Glitters (Mentioned 2:34:37, Ep 232) John Lyons - Balcony Over Jerusalem (Mentioned 2:45:26, Ep 231) Yukio Mishima - Spring Snow (Mentioned 2:35:12, Ep 227) John Steinbeck - Cannery Row (Mentioned 02:39, Ep 226) David Simon & Ed Burns - The Corner: A Year in the Life of an Inner-City Neighborhood (Mentioned 2:21:40, Ep 225) William Appleman Williams - The Tragedy of American Diplomacy (Mentioned 2:11:23, Ep 222) Mahmood Mamdani - Good Muslim, Bad Muslim (Mentioned 2:07:14, Ep 220) Carlo Rovelli - The Order Of Time (Mentioned 06:36, Ep 220) Carlo Rovelli - Reality Is Not What It Seems (Mentioned 06:36, Ep 220) Ryszard Kapuściński - Shah of Shahs (Mentioned 2:21:27, Ep 217) Ervand Abrahamian - Khomeinism (Mentioned 2:23:19, Ep 217) Anthony Seldon - Truss at 10 (Mentioned 1:36:09, Ep 215) Steven Teles - The Conservative Legal Movement (Mentioned 2:12:12, Ep 215) Amin Maalouf - The Crusades Through Arab Eyes (Mentioned 4:32, Ep 214) Geoffrey Blainey - The Causes Of War (Mentioned 43:49, Ep 198) Margaret Levi - Of Rule And Revenue (Mentioned 1:11:16, Ep 195) Margaret Levi - Consent, Dissent, and Patriotism (Mentioned 1:11:16, Ep 195) Sayaka Murata - Convenience Store Woman (Mentioned 2:14, Ep 194) Sid Meier - Sid Meier's Memoir! (Mentioned 16:30, Ep 178) David Simon & Ed Burns - The Corner (Mentioned 8:40, Ep 178) Maurice O. Wallace - King's Vibrato (Mentioned 14:26, Ep 164) Edward S. Herman and Noam Chomsky - Manufacturing Consent - (Mentioned 32:12, Ep 164) Robert Plunket - My Search For Warren Harding (Mentioned 1:49:12, Ep 158) Ian Lambot & Greg Girard - City of Darkness Revisited (Mentioned 39:25, Ep 157) Max Chafkin - The Contrarian (Mentioned 32:18, Ep 155) Claire Conner - Wrapped In The Flag (Mentioned 31:42, Ep 155) Rita Abrahamsen, Mike Williams et al - Global Right (Mentioned 31:12, Ep 155) Philip Gorski and Samuel Perry - The Flag And The Cross (Mentioned 30:49, Ep 155) Cynthia Miller-Idriss - Hate In The Homeland (Mentioned 30:10, Ep 155) Cory Doctorow & Rebecca Giblin - Chokepoint Capitalism (Mentioned 34:55, Ep 150) Elizabeth Ingleson - Made In China (Mentioned 31:50, Ep 150) John Corrigan - Religious Intolerance, America, and the World (Mentioned 1:16:18, Ep 141) Gérard Prunier - From Genocide to Continental War (Mentioned 48:18, Ep 141) Liu Cixin, - The Three Body Trilogy (Mentioned 1:11:04, Ep 136) Tilman Allert - The Hitler Salute (Mentioned 22:03, Ep 134) Philip Roth - Nemesis (Mentioned 1:56, Ep 133) Joshua Cohen - The Netanyahus Zeke Faux - Number Go Up Michael Paul Rogin - The Intellectuals and McCarthy Cathy Kramer - The Politics of Resentment Naomi Klein - Doppelganger Maria Bamford - Sure, I'll Join Your Cult Wendy Brown - States Of Injury Corey Robin. - The Reactionary Mind Patricia Lockwood - No One Is Talking About This David Cay Johnston - The Making of Donald Trump Jane Mayer - Dark Money Harry Frankfurt - On Bullshit Stephen King - The Dead Zone Elle Hardy - Beyond Belief Federico Finchelstein - From Fascism to Populism in History Robert Jervis - Why Intelligence Fails Alex Haley and Malcolm X - The Autobiography of Malcolm X Jonathan Haidt - The Righteous Mind David Graeber - Debt: The First 5000 Years Jerry L. Mashaw - Creating The American Administrative Constitution Brian Balogh - A Government Out of Sight Paul Connerton - How Societies Remember Paul Connerton - How Modernity Forgets Catherine Green and Sarah Catherine Gilbert - Vaxxers John Zaller - The Nature and Origins of Mass Opinion Matthew Karp - This Vast Southern Empire Robert Fatton - The Guise of Exceptionalism Anatol Lievin - Climate Change and the Nation State: The Realist Case James Alfred Aho - The Politics of Righteousness The substack that Dr Dave apparently plagiarises liberally from! https://luke.substack.com/ James Beverley - God's Man in the White House Jane Chi Hyun Park - Yellow Future Matthias Gardell - In The Name of Elijah Muhammad Gosta Esping-Andersen - The Three Worlds of Welfare Capitalism Suzanne Mettler - The Submerged State Brendon O'Connor - Anti-Americanism and American Exceptionalism James Morone - Hellfire Nation Nathan Kalmoe - With Ballots and Bullets Winnifred Fallers Sullivan - The Impossibility of Religious Freedom Mary L. Trump - Too Much And Never Enough Richard Cooke - Tired of Winning Jon Ronson - So You've Been Publicly Shamed Rodney Tiffen, Ross Gittins, Anika Gauja, David Smith, Brendon O'Connor - How America Compares Tony Horwitz - Confederates In the Attic Ghassan Hage - White Nation George Lakoff - Women, Fire and Dangerous Things George Lakoff - Metaphors We Live By Michelle Alexander - The New Jim Crow Alex S. Vitale - The End of Policing Dave Cullen - Parkland: Birth of a Movement Thomas Sugrue - The Origins of the Urban Crisis Rick Pearlstein - The Invisible Bridge Rick Pearlstein - Before the Storm Rick Pearlstein - Nixonland Brian Doherty - Radicals for Capitalism Leon Festinger, Henry W. Riecken, Stanley Schachter - When Prophecy Fails Nancy L. Rosenblum & Russell Muirhead - A Lot Of People Are Saying Benjamin Moffitt - The Global Rise of Populism Jon Krakauer - Missoula THANK YOU FOR YOUR ATTENTION TO THIS MATTER!  

Bernie starts off the show talking about the horrible product that is NBA All-Star weekend and the NBA in general. Amal Shah stops by before The Midnight Hour. Topics in The Midnight Hour include whether or not players should be able to vote on the NFL Hall Of Fame inductees, if Deion Sanders' comments about the NFL disrespecting Shedeur are actually going to make a difference if he'd coach in the NFL eventually, and if LeBron were to retire at the end of the season would Bronny James be on the Lakers next year? Bernie then discusses how Adam Silver can help fix tanking in the NBA and why Ty Simpson is the QB2 in a very weak NFL Draft class. New Editions of Fantasy Files and World Of Soccer follow. See omnystudio.com/listener for privacy information.

This week, an interview with Aryanum, a member of the Persian-language anarchist group Anarchism Perspective, based in Iran and Afghanistan. Anarchism Perspective is a synthesist anarchist group based mostly in the region that organizes solidarity and resistance as well as publishing writings at Anarshism.com . For this episode, we speak about the recent uprising in Iran that was met with bloody repression by the regime, with internet blackouts and low-ball estimates of 30,000 dead at government hands from January 8th and 9th 2026 alone. Aryanum speaks about the posturing by monarchists supporting the return and enthroning of Reza Pahlavi II, the son of the last Shah, and the weaponization of Islam by the Mullahs of the regime and other topics. Anarchism Perspective links Website: https://anarshism.com email: contact@anarshism.com Anarchism Perspective Telegram: https://t.me/+RRUTo6xyoT468fgO & https://t.me/anarchism_perspective Insurrection Library: https://t.me/Insurrection_Library Other Links Critique of Mass Mobilization by Anarchism Perspective: https://www.anarshism.com/critique-mass-mobilization-strategy/ Aryanum's past writing on religion as a type of power: https://www.anarshism.com/funeral-theocracy-religious-capital-en/ Article on labor struggles in the run up to the uprising: https://classautonomy.info/workers-councils-reportedly-forming-in-iran/ It Could Happen Here interview: https://www.iheart.com/podcast/105-it-could-happen-here-30717896/episode/whats-happening-in-iran-317260060/ CNN report on mass deaths: https://www.cnn.com/2026/01/10/middleeast/tehran-iran-protests-deaths-arrests-intl Basij volunteer milita of IRGC: https://en.wikipedia.org/wiki/Basij Hrana (Kurdish human rights group): https://www.en-hrana.org/category/news/ https://theanarchistlibrary.org/library/decolonize-anarchism-in-praise-of-burning-down-clerical-fascism-in-iran https://www.hauntologies.net/p/iranian-protesters-dont-owe-us-an Thread on mastodon about the usefulness of Delta Chat via locally run servers when the internet (and therefore connection to Signal) was cut off: https://archive.ph/GBR6A 70% of Iraniun population suffers from malnutrition: https://ghalamrorefah.ir/id/1959/ Another Farsi Group, Anarchist Front: https://t.me/AnarchistFront1 https://links.anarchist-front.org/ https://link.kompektiva.org/@anarchistfront https://anarchistfront.noblogs.org https://t.me/anegofromworldgap https://t.me/AnarchistFront . … . .. Featured Track: TFSR by The Willows Whisper

Beatrice Adler-Bolton, Silky Shah and Harsha Walia discuss the brutal enforcement of immigration policing in Minneapolis and beyond, and why resistance calls for the abolition of much more than ICE. This episode was recorded live on February 12th 2026 in collaboration with Haymarket Books. You can watch the original livestream on youtube here: https://www.youtube.com/watch?v=d9YJqx1zY2c To support the show and help make episodes like this one possible, become a patron at www.patreon.com/deathpanelpod Find Harsha Walia's book Border and Rule: Global Migration, Capitalism, and the Rise of Racist Nationalism here: https://bookshop.org/a/118130/9781642592696 Find Silky Shah's book Unbuild Walls: Why Immigrant Justice Needs Abolition here: https://bookshop.org/a/118130/9798888900840 Show links: Get Health Communism here: bookshop.org/a/118130/9781839765179 Find Tracy's book Abolish Rent here: bookshop.org/a/118130/9798888902523 Find Jules' latest book, A Short History of Trans Misogyny, here: bookshop.org/a/118130/9781804291603