Podcasts about protective immunity

Are you totally confused by probiotics or not sure which one to choose? Want to ensure you are getting the best bang for your buck and that your probiotic is actually doing something? Curious about how to pulse your probiotics based on symptoms and season? Tune in to hear Ali and Becki go down the rabbit hole on strain-specific research and discuss what to look for in a probiotic, best formulas for desired clinical outcomes, and how to tell if a probiotic is good quality.    In this episode, Ali and Becki go into detail on some of the most widely researched probiotic strains, from lactobacillus to bifidobacterium to saccharomyces boulardii and beyond. Learn about promising clinical outcomes from reduction of IBS and IBD pain, regulation of bowels post antibiotic, prevention of candida overgrowth, and yeast infection and UTI treatment. Plus we discuss thoughts on probiotics formulated with prebiotics as well as some of the new spore-based probiotics and share our current favorite cultured foods to get a daily dose of probiotics!   Also in this episode: 12 Week Virtual Ketosis Program - Only $99 through 9/1!  Episode 230: Dysbiosis through Disconnection Episode 198: So You're On an Antibiotic Episode 174: The Dysbiosis Disease Connection and Ali's Cleanse Episode 60: Dysbiosis and the Microbiome Episode 68: Supporting Your Immune System Naturally (Deep dive on ear infections & antibiotic use in kids) Episode 87: The Gut Brain Axis Episode 131: Candida and SIBO Deep Dive What is the Microbiome? The Role of Probiotics Probiotics and Immune Health Belkaid Y, Hand TW. 2014. Role of the microbiota in immunity and inflammation. Cell157: 121–141. https://doi.org/10.1016/j.cell.2014.03.011  Collins, N., & Belkaid, Y. (2018). Do the Microbiota Influence Vaccines and Protective Immunity to Pathogens? Engaging Our Endogenous Adjuvants. Cold Spring Harbor perspectives in biology, 10(2), a028860. https://doi.org/10.1101/cshperspect.a028860  Kim, C.H. (2018), Immune regulation by microbiome metabolites. Immunology, 154: 220-229. doi:10.1111/imm.12930  Pickard, J. M., Zeng, M. Y., Caruso, R., & Núñez, G. (2017). Gut microbiota: Role in pathogen colonization, immune responses, and inflammatory disease. Immunological reviews, 279(1), 70–89. https://doi.org/10.1111/imr.12567  What to Look for When Choosing a ProbioticID Guarantee Why We Don't Include Prebiotics in Our ProbioticsPhytofiber Strain Specific ResearchLactobacillus Acidophilus NCFMD'Souza, B., et al. (2015), ‘Randomized controlled trial of probiotics after colonoscopy'. ANZ Journal of Surgery, doi: 10.1111/ans.13225. Engelbrektson, A.L .et al., (2009). ‘Probiotics to minimize the disruption of faecal microbiota in healthy subjects undergoing antibiotic therapy'. Journal of Medical Microbiology, 58:663-670. Engelbrektson, A.L. et al., (2006). ‘Analysis of treatment effects on the microbial ecology of the gastrointestinal tract'. FEMS Microbiol. Ecol. 57:239-250. Faber S.E., (2003), ‘Comparison of probiotics with antibiotics to probiotics alone in treatment of diarrhea predominant IBS (D-IBS), alternating (A-IBS) and constipation (C-IBS) patients', Gastroenterology, 124(4):A687-A688. Faber, S.M., (2000). ‘Treatment of abnormal gut flora improves symptoms in patients with irritable bowel syndrome'. American Journal of Gastroenterology, 95(9):2533. Forssten, S., et al., (2014). ‘Influence of a probiotic mixture on antibiotic induced microbiota disturbances'. World Journal of Gastroenterology, 20(33):11878-85. Leyer, G.J., et al., (2009). ‘Probiotic Effects on Cold and Influenza-Like Symptom Incidence and Duration in Children'. Pediatrics; 124 (2): 172-179. Restore Baseline Probiotic Targeted Strength Probiotic - use code TARGETPRO18 for 18% off  KidsBiotic How to Take Probiotics With Antibiotics Bifidobacterium lactis Bi-07Gobel et al., (2010). ‘Probiotics to young children with atopic dermatitis: A randomized placebo-controlled trial'. International Journal of Probiotics and Prebiotics, 5(2):53-59. Lammers, K.M., (2003). ‘Immunomodulatory effects of probiotic bacteria DNA: IL-1 and IL-10 response in human peripheral blood mononuclear cells'. FEMS Immunology and Medical Microbiology 38: 165-172. Leyer G.J. et al., (2009). ‘Probiotic effects on cold and influenza-like symptom incidences and duration in children'. Pediatrics, 124:72-179. Maneerat S. et al., (2013). ‘Consumption of Bifidobacterium lactis Bi-07 by healthy elderly adults enhances phagocytic activity of monocytes and granulocytes' J Nutr Sci.., 2(2):e44. Masco L. et al., (2004). ‘Polyphasic taxonomic analysis of Bifidobacterium animalis and Bifidobacterium lactis reveals relatedness at the subspecies level: reclassification of Bifidobacterium animalis subsp. Animalis subsp. nov. and Bifidobacterium lactis as Bifidobacterium animalis subsp. Lactis subsp. Nov'. Int. J. System. Evol. Microbiol., 54(4): 1137-1143. Lactobacillus PlantarumRebuild Spectrum Probiotic Post Surgical Protocol Saccharomyces BoulardiiAbbas Z. et al., (2014), ‘Cytokine and clinical response to Saccharomyces boulardii therapy in diarrhea-dominant irritable bowel syndrome: a randomized trial', Eur J Gastroenterol Hepatol, 26(6):630-9. Akil I. et al., (2006), ‘Influence of oral intake of Saccharomyces boulardii on Escherichia coli in enteric flora', Pediatr Nephrol, 21(6):807-10. Algin C., et al. (2005) ‘Effectiveness of Bombesin and Saccharomyces boulardii against the translocation of Candida albicans in the digestive tract in immunosuppressed rats'. Surgery Today, 35: 869. Bafutto M. et al., (2013), ‘Treatment of diarrhea-predominant irritable bowel syndrome with mesalazine and/or Saccharomyces boulardii',Arq Gastroenterol, 50(4):304-9. Berg R. et al., (1993), ‘Inhibition of Candida albicans translocation from the gastrointestinal tract of mice by oral administration of Saccharomcyes boulardii'. J. Infect. Dis. 168(5):1314-8. Billoo A.G. et al., (2006), ‘Role of a probiotic (Saccharomyces boulardii) in management and prevention of diarrhoea', World J Gastroenterol, 12(28):4557-60. Bin, Z., et al. (2015). The Efficacy of Saccharomyces boulardii CNCM I-745 in Addition to Standard Helicobacter pylori Eradication Treatment in Children. Pediatric Gastroenterology, Hepatology & Nutrition, 18(1), 17–22. Blehaut, H. et al., (1989) ‘Disposition kinetics of Saccharomyces boulardii in man and rat'. Biopharm Drug Dispos, 10: 353–364. Bruggencate T., (2015), ‘The effect of a multi-strain probiotic on the resistance toward Escherichia coli challenge in a randomized, placebo-controlled, double-blind intervention study'. European Journal of Clinical Nutrition, 69:385-391. Burande M.A., (2013), ‘Comparison of efficacy of Saccharomyces boulardii strain in the treatment of acute diarrhea in children: A prospective, single-blind, randomized controlled clinical trial', J Pharmacol Pharmacother, 4(3):205-8. Buts J. et al., (1993), ‘Saccharomyces boulardii for Clostridium difficile-Associated Enteropathies in Infants'. Journal of Pediatric Gastroenterology and Nutrition, 16:419-425. Lactobacillus rhamnosus & Lactobacillus reuteriAnukam et al., (2006), ‘Clinical study comparing probiotic Lactobacillus GR-1® and RC-14® with met*******ole vaginal gel to treat symptomatic bacterial vaginosis'. Microbes Infect.8(12-13):2772-6. Anukam K.C. et al., (2006), ‘Augmentation of antimicrobial met*******ole therapy of bacterial vaginosis with oral probiotic Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14: randomized, double-blind, placebo controlled trial'. Microbes Infect. 8(6): 1450-4. Anukam et al., (2009), ‘Oral use of probiotics as an adjunctive therapy to fluconazole in the treatment of yeast vaginitis: A study of Nigerian women in an outdoor clinic'. Microb. Ecol. Health Dis., 21(2):72-77. Beerepoot et al., (2012), ‘Lactobacilli vs antibiotics to prevent urinary tract infections: a randomized, double-blind, noninferiority trial in postmenopausal women'. Arch. Intern. Med., 172(9):704-12. Women's Flora Probiotic BacteriophagesGI Clean Up Probiotic Challenge Choosing the Right Probiotic Chart What About Soil Based Probiotics Favorite Probiotic Foods   Sponsors for this Episode:  This episode is sponsored by the Naturally Nourished supplement line: these pure, potent and effective formulas have been hand selected to deliver profound health benefits. We price our formulas 2-5% below market industry standard and competitors and guarantee that our products will always be third party assessed to ensure they are free of mold, toxins, contaminants, and contain the stated active ingredients in dosages noted.  Use code ALI15 for 15% off your first Naturally Nourished Supplement Order!    This episode is also sponsored by Santa Cruz Medicinals, makers of potent and affordable CBD with effective dosing. For more information check out www.scmedicinals.com and use code ALIMILLERRD for 15% off your order. 

The very best immunity is natural immunity. That comes to us from Israeli data which is complete enough to draw real conclusions from. The vaccines offer varying degrees of protection from hospitalization and death that are much improved as compared to

10 September 2013: Join Dr. Robert Dellavalle as he speaks with Dr. Thomas Kupper, from Brigham and Women's Hospital at Harvard Medical School, about vaccines in the context of tissue-resident memory T cells and the role of these cells in skin -- and other epithelial interfaces with the environment -- in the maintenance of protective immunity.

Professor Fiona Powrie talks about the importance of our guts, and her research in gastroenterology.

Professor Fiona Powrie talks about the importance of our guts, and her research in gastroenterology.

Professor Fiona Powrie talks about the importance of our guts, and her research in gastroenterology.

Professor Fiona Powrie talks about the importance of our guts, and her research in gastroenterology.

Dr Seph Borrow tells us how her research on HIV Immunology helps design better vaccines. There is an urgent need for vaccines to combat persistent infections like HIV. The earliest interactions between HIV and host immune responses determine the course of the disease. Dr Seph Borrow is studying factors affecting virus control by HIV-specific CD8+ T cells, to inform the design of T cell-based HIV vaccines. Dr Borrow is also exploring the possibility of harnessing innate immune responses to combat HIV.

Dr Seph Borrow tells us how her research on HIV Immunology helps design better vaccines. There is an urgent need for vaccines to combat persistent infections like HIV. Dr Seph Borrow is studying factors affecting virus control by HIV-specific CD8+ T cells, to inform the design of T cell-based HIV vaccines. She is also exploring the possibility of harnessing innate immune responses to combat HIV.

Dr Seph Borrow tells us how her research on HIV Immunology helps design better vaccines. There is an urgent need for vaccines to combat persistent infections like HIV. Dr Seph Borrow is studying factors affecting virus control by HIV-specific CD8+ T cells, to inform the design of T cell-based HIV vaccines. She is also exploring the possibility of harnessing innate immune responses to combat HIV.

Dr Seph Borrow tells us how her research on HIV Immunology helps design better vaccines. There is an urgent need for vaccines to combat persistent infections like HIV. The earliest interactions between HIV and host immune responses determine the course of the disease. Dr Seph Borrow is studying factors affecting virus control by HIV-specific CD8+ T cells, to inform the design of T cell-based HIV vaccines. Dr Borrow is also exploring the possibility of harnessing innate immune responses to combat HIV.

We have shown in a murine model system for acute, lethal cytomegalovirus (CMV) disease in the immunocompromised natural host that control of virus multiplication in tissues, protection from virus-caused tissue destruction, and survival are mediated by virus-specific CD8+ CD4-T lymphocytes. Protection from a lethal course of disease did not result in a rapid establishment of virus latency, but led to a long-lasting, persistent state of infection. The CD8- CD4+ subset of T lymphocytes was not effective by itself in controlling murine CMV (MCMV) multiplication in tissue or essential for the protective function of the CD8+ CD4- effector cells. The antiviral efficacy of the purified CD8+ CD4- subset was not impaired by preincubation with fibroblasts that presented viral structural antigens, but was significantly reduced after depletion of effector cells specific for the nonstructural immediate-early antigens of MCMV, which are specified by the first among a multitude of viral genes expressed during MCMV replication in permissive cells. Thus, MCMV disease provides the first example of a role for nonstructural herpesvirus immediate-early antigens in protective immunity.