Podcasts about Clinical nutrition

What if one of the most powerful medicines for longevity, resilience, happiness, cognitive health, and disease prevention wasn't found in a supplement, a prescription, or a cutting-edge biohack—but in the people around you? In this powerful solo episode, Darin Olien dives into one of the most overlooked health crises of our time: loneliness. Drawing from the landmark 85-year Harvard Adult Development Study, the U.S. Surgeon General's loneliness epidemic report, Blue Zones research, neuroscience, and evolutionary biology, Darin reveals why meaningful human connection may be one of the strongest predictors of health and longevity ever discovered. From oxytocin, cortisol, inflammation, vagal tone, and nervous system regulation to suburban design, social media, and the collapse of community structures, Darin exposes the hidden biological costs of isolation—and offers a practical roadmap for rebuilding the human connections we were biologically designed to need.     What You'll Learn The stunning findings from Harvard's 85-year Adult Development Study Why relationships outperform wealth, genetics, diet, and exercise as predictors of well-being How loneliness increases the risk of premature death, dementia, heart disease, and stroke Why social isolation creates measurable biological stress responses The role of oxytocin in lowering inflammation and regulating stress How human connection affects the autonomic nervous system Why Blue Zone communities consistently prioritize social connection The biological difference between digital interaction and real human presence How modern architecture and technology contribute to loneliness Why community is a biological necessity—not a luxury Practical ways to rebuild meaningful relationships today How connection may be one of the most powerful health interventions available   Chapters 00:00:00 – Welcome to SuperLife 00:00:33 – Sponsor: Bite Toothpaste and reducing plastic waste 00:02:49 – The most powerful health study ever conducted 00:03:01 – Harvard follows 724 people for 85 years 00:03:40 – The surprising predictor of a long, healthy life 00:04:00 – Why relationships beat wealth, genetics, diet, and exercise 00:04:42 – The Surgeon General's loneliness epidemic warning 00:05:19 – Introducing the medicine you're not taking 00:05:53 – The health benefits of genuine community 00:06:21 – The fatal convenience of modern life 00:06:47 – Replacing human connection with digital connection 00:07:12 – Why modern convenience may be creating isolation 00:07:23 – Social isolation and premature mortality 00:08:02 – Loneliness and the equivalent of smoking 15 cigarettes a day 00:08:43 – Increased risks of heart disease, stroke, and dementia 00:09:10 – Why loneliness is a biological threat 00:09:52 – The science behind social isolation 00:10:11 – Sponsor: Manna Vitality 00:12:06 – Humans as the most socially dependent species 00:12:53 – Why connection regulates the nervous system 00:13:29 – The autonomic nervous system and social safety 00:13:56 – The brain's constant question: Am I safe? 00:14:03 – The biology of belonging 00:14:24 – The ventral vagal state explained 00:14:55 – Why connection creates measurable physiological changes 00:15:03 – What happens when isolation becomes chronic 00:15:52 – Oxytocin: far more than the "love hormone" 00:16:20 – Eye contact, touch, meals, and human bonding 00:16:42 – How oxytocin lowers stress and inflammation 00:17:04 – Why no supplement can replace connection 00:17:17 – The pharmacology of authentic human moments 00:18:06 – Free medicine hidden in plain sight 00:18:39 – Dan Buettner and the Blue Zones 00:19:29 – What the world's longest-lived populations have in common 00:19:36 – Okinawa's lifelong friendship circles 00:20:08 – Sardinia's active elders and social roles 00:20:40 – Greece's culture of connection and communal meals 00:21:03 – Why longevity wasn't hacked—it was lived 00:21:38 – Social connection as the foundation of daily life 00:22:01 – The shocking decline in face-to-face interaction 00:22:21 – Young people losing 70% of in-person social time 00:22:58 – How community was systematically dismantled 00:23:00 – Robert Putnam's Bowling Alone 00:23:49 – Doing life together versus doing life alone 00:24:05 – How suburban design creates isolation 00:24:49 – The built environment shapes human behavior 00:24:55 – Social media and the promise of connection 00:25:20 – Why digital connection fails biologically 00:25:33 – Social comparison, anxiety, and nervous system stress 00:25:49 – More connected online, more isolated in reality 00:26:03 – A call to action: treating relationships like health practices 00:27:00 – Practical ways to rebuild community 00:28:00 – Prioritizing people over convenience 00:29:00 – Deep conversations, presence, and intentional connection 00:30:00 – Reclaiming community in modern life 00:31:00 – Final thoughts on connection, belonging, and health 00:31:53 – Closing remarks and outro     Thank You to Our Sponsors Bite Toothpaste: Go to trybite.com/DARIN20 or use code DARIN20 for 20% off your first order Manna Vitality: Go to mannavitality.com/ and use code DARIN12 for 12% off your order.     Join the SuperLife Patreon: This is where Darin now shares the deeper work: - weekly voice notes - ingredient trackers - wellness challenges - extended conversations - community accountability - sovereignty practices Join now for only $7.49/month at https://patreon.com/darinolien     Find More from Darin Olien: Website: darinolien.com Instagram: @darinolien Book: Fatal Conveniences Platform & Products: superlife.com New Show: Roadmap to Happiness     Key Takeaway "The longest-running study in human history reached a conclusion that should fundamentally change how we think about health: the quality of our relationships predicts our happiness, resilience, and longevity more than almost anything else. Human connection isn't a luxury, a personality trait, or a nice bonus when life slows down. It is biology. It is medicine. And in a world increasingly designed for isolation, rebuilding community may be one of the most important health decisions we ever make."     Bibliography/Sources: Primary Research — Loneliness, Social Isolation & Health Associated Press. (2023, May 2). Surgeon general: Loneliness poses health risks as deadly as smoking. PBS NewsHour. https://www.pbs.org/newshour/health/surgeon-general-loneliness-poses-health-risks-as-deadly-as-smoking Cacioppo, J. T., & Hawkley, L. C. (2009). Perceived social isolation and cognition. Trends in Cognitive Sciences, 13(10), 447–454. https://doi.org/10.1016/j.tics.2009.06.005 Holt-Lunstad, J., Smith, T. B., & Layton, J. B. (2010). Social relationships and mortality risk: A meta-analytic review. PLoS Medicine, 7(7), e1000316. https://doi.org/10.1371/journal.pmed.1000316 Office of the Surgeon General. (2023). Our epidemic of loneliness and isolation: The U.S. Surgeon General's advisory on the healing effects of social connection and community. U.S. Department of Health and Human Services. https://www.hhs.gov/sites/default/files/surgeon-general-social-connection-advisory.pdf Waldinger, R. J., & Schulz, M. S. (2010). What's love got to do with it? Social functioning, perceived health, and daily happiness in married octogenarians. Psychology and Aging, 25(2), 422–431. https://doi.org/10.1037/a0019087 Neuroscience — Oxytocin, Polyvagal Theory & Community Biology Carter, C. S. (1998). Neuroendocrine perspectives on social attachment and love. Psychoneuroendocrinology, 23(8), 779–818. https://doi.org/10.1016/S0306-4530(98)00055-9 Eisenberger, N. I., & Lieberman, M. D. (2004). Why rejection hurts: A common neural alarm system for physical and social pain. Trends in Cognitive Sciences, 8(7), 294–300. https://doi.org/10.1016/j.tics.2004.05.010 Heinrichs, M., Baumgartner, T., Kirschbaum, C., & Ehlert, U. (2003). Social support and oxytocin interact to suppress cortisol and subjective responses to psychosocial stress. Biological Psychiatry, 54(12), 1389–1398. https://doi.org/10.1016/S0006-3223(03)00465-7 Porges, S. W. (2011). The polyvagal theory: Neurophysiological foundations of emotions, attachment, communication, and self-regulation. W. W. Norton & Company. https://wwnorton.com/books/9780393707007 Blue Zones Research Buettner, D., & Skemp, S. (2016). Blue Zones: Lessons from the world's longest lived. American Journal of Lifestyle Medicine, 10(5), 318–321. https://doi.org/10.1177/1559827616637066 Kreouzi, M., Theodorakis, N., & Constantinou, C. (2022). Lessons learned from Blue Zones, lifestyle medicine pillars and beyond. American Journal of Lifestyle Medicine. https://doi.org/10.1177/15598276221118494 Suzuki, M., Willcox, B. J., & Willcox, D. C. (2001). Implications from and for food cultures for cardiovascular disease: Longevity. Asia Pacific Journal of Clinical Nutrition, 10(2), 165–171. https://doi.org/10.1111/j.1440-6047.2001.00219.x The power of environment: A comprehensive review of the exposome's role in healthy aging. (2025). PubMed Central (PMC11858149). https://pmc.ncbi.nlm.nih.gov/articles/PMC11858149/ Social Capital & Community Decline Oldenburg, R. (1999). The great good place: Cafés, coffee shops, bookstores, bars, hair salons, and other hangouts at the heart of a community. Marlowe & Company. https://books.google.com/books?id=cK80BwAAQBAJ Putnam, R. D. (2000). Bowling alone: The collapse and revival of American community. Simon & Schuster. https://www.simonandschuster.com/books/Bowling-Alone/Robert-D-Putnam/9780743203043 Sbarra, D. A., Briskin, J. L., & Slatcher, R. B. (2019). Smartphones and close relationships: The case for an evolutionary mismatch. Perspectives on Psychological Science, 14(4), 596–618. https://doi.org/10.1177/1745691619826535 Twenge, J. M., Joiner, T. E., Rogers, M. L., & Martin, G. J. (2018). Increases in depressive symptoms, suicide-related outcomes, and suicide rates among U.S. adolescents after 2010 and links to increased new media screen time. Journal of Adolescent Health, 62(1), 78–85. https://doi.org/10.1016/j.jadohealth.2017.06.014 U.S. Bureau of Labor Statistics. (2020). American time use survey. U.S. Department of Labor. https://www.bls.gov/tus/ Pennebaker & Authentic Disclosure Brown, B. (2012). Daring greatly: How the courage to be vulnerable transforms the way we live, love, parent, and lead. Gotham Books. https://brenebrown.com/book/daring-greatly/ Pennebaker, J. W. (1997). Writing about emotional experiences as a therapeutic process. Psychological Science, 8(3), 162–166. https://doi.org/10.1111/j.1467-9280.1997.tb00403.x

Most of us have had that moment where we get our bloodwork back and shake our heads. We're still our active, health‑minded selves and out of nowhere—rising LDL, ApoB, A1C, and maybe blood pressure and Lp(a), too. This week, preventive cardiology dietitian Michelle Routhenstein joins us to unpack the cardiometabolic chaos and what's really driving it. She explains estrogen's protective role in lipids and blood pressure, why standard risk calculators and even calcium scores can miss women's disease, and which advanced labs are worth asking for. We also dig into how under‑fueling and low‑carb diets can worsen cardiometabolic health and plaque; why complex carbs, fiber, fermented foods, and gut health matter so much; and how to approach protein, red meat, electrolytes, nitric oxide, and statins in a personalized, empowering way—remembering that 80–90% of heart disease remains preventable when women get the right information and advocate for themselves.Michelle Routhenstein, MS, RD, CDCES, CDN is a preventive cardiology dietitian and founder of Entirely Nourished, a virtual practice focused on personalized, science-based nutrition for heart health. With over 14 years of experience, she helps people improve cardiometabolic risk and manage conditions like atherosclerosis, heart failure, and atrial fibrillation using a whole-person approach. She holds Bachelor's and Master's degrees in Clinical Nutrition from New York University, serves on the Forbes Health Advisory Board and the Medical Advisory Committee for the National Menopause Foundation, and is the author of The Truly Easy Heart-Healthy Cookbook and Simple Meal Solutions for High Blood Pressure. Her work has been featured in outlets including Forbes Health, Fox News, Prevention, Women's Health, and Good Housekeeping, and she works with clients virtually from New York via www.entirelynourished.comJoin us at Feisty Fest September 18-20, 2026: https://feisty.co/events/feisty-fest/Sign up for our FREE Feisty 40+ newsletter: https://feisty.co/feisty-40/Learn More about our 2026 Feisty Events, including Bike Camps and Cycling Trips: https://feisty.co/events/Follow Us on Instagram:Feisty Menopause: @feistymenopauseHit Play Not Pause Facebook Group: https://www.facebook.com/groups/807943973376099Support our Partners:Midi Health: You Deserve to Feel Great. Book your virtual visit today at https://www.joinmidi.com/Previnex: Get 20% off your order with code FEISTYBRAIN at https://www.previnex.com/ Wahoo: Use the code FEISTY2026 to get a free Headwind Smart Fan (value $300) with the purchase of a Wahoo KICKR RUN at https://shorturl.at/WVhdrCozy Earth: Use Code HITPLAY at https://cozyearth.com/ for up to 20% off

Learn how fat buildup in muscle cells disrupts insulin and how a low-fat plant-based diet restores metabolic function. #Type2Diabetes #InsulinResistance #LowFatVegan

Body composition goals, particularly bodyfat loss, are among the most common reasons people seek support from a nutritionist or health and fitness professional. While the principles are well established, the challenge is helping individuals apply them consistently in real-world conditions. Many people struggle due to hunger, unrealistic expectations, emotional eating, inconsistent routines, or overly restrictive dieting approaches. These challenges can make fat loss difficult to sustain, even when someone understands what they "should" be doing. In this episode,  Luke Hanna discusses practical strategies for improving body composition, including food diaries, energy-density manipulation, preloads, mindful eating, and realistic goal-setting. The discussion emphasizes identifying individual barriers, collaborating with clients, and building repeatable behaviours that support both fat loss and long-term maintenance. Luke Hanna holds a Master's degree in Obesity and Clinical Nutrition from University College London and a degree in Sport and Exercise Science from the University of Portsmouth. He currently works as a nutrition coach and personal trainer. Timestamps: [03:15] Interview [05:39] Client assessment basics [11:59] Alternatives to tracking [13:57] Volume eating [18:56] Preloads before meals [22:25] Snacking and hunger types [26:44] Habits and food environment [30:40] Managing expectations [33:51] Transition to maintenance [39:09] Key ideas (premium-only) Links: Go to episode page (with resources) Join the Sigma newsletter for free Subscribe to Sigma Nutrition Premium Instagram: @lukehannanutrition

Support the Institute today. https://givenow.nova.edu/the-institute-for-neuro-immune-medicine-inim-2025   In today's episode, Haylie Pomroy sits down with Dr. Annie Lin, a licensed board-certified nutrition specialist in integrative and functional nutrition, for a conversation that gets to the root of why food is not just part of the healing equation. It is the foundation of it.   Dr. Lin walks through the science of chronic inflammation as a physiologic process, one that can be triggered by stress, viral infection, environmental toxins, and food itself. She explains how food functions as information for our genes, activating or quieting inflammatory pathways depending on what we consume. Together, Haylie and Dr. Lin make the case for clinical nutrition as a non-negotiable member of every care team, not an afterthought.   They also explore the role of culinary spices as targeted, nutrient-dense medicine; the nutrient depletion side effects that often go unaddressed when patients are prescribed medications; and why the initial patient intake, the moment someone finally feels heard and validated, can be the turning point in a healing journey.   Dr. Annie Lin is a Licensed and Board-Certified Nutrition Specialist focusing on integrative and functional nutrition approaches for optimizing health and addressing root causes of clinical imbalances. She is a dedicated assistant professor in the Department of Nutrition, teaching a variety of courses including functional nutrition in the graduate program. With a doctorate in Clinical Nutrition from Maryland University of Integrative Health, and training from the Institute for Functional Medicine, she combines academic rigor with practical expertise in using Food as Medicine. Facebook: https://www.facebook.com/ayeenlin/  LinkedIn: https://www.linkedin.com/in/annielin1/  Instagram: https://www.instagram.com/ayeenlin/    INIM Nutrition Services Available For appointments with Dr. Annie Lin, contact the INIM Clinic at 954-262-2850.   Haylie Pomroy, Founder and CEO of The Haylie Pomroy Group, is a leading health strategist specializing in metabolism, weight loss, and integrative wellness. With over 25 years of experience, she has worked with top medical institutions and high-profile clients, developing targeted programs and supplements rooted in the "Food is Medicine" philosophy. Inspired by her own autoimmune journey, she combines expertise in nutrition, biochemistry, and patient advocacy to help others reclaim their health. She is a New York Times bestselling author of The Fast Metabolism Diet.   Learn more about Haylie Pomroy's approach to wellness through her website: https://hayliepomroy.com   Instagram: https://www.instagram.com/hayliepomroy  Facebook: https://www.facebook.com/hayliepomroy  YouTube: https://www.youtube.com/@hayliepomroy/videos  LinkedIn: https://www.linkedin.com/in/hayliepomroy/  X: https://x.com/hayliepomroy    Thank you for tuning in to the Hope and Help For Fatigue and Chronic Illness Podcast. Sign up today for our newsletter.

Does GABA Actually Help With Sleep? What the Research Says for Brain Injury Recovery Someone in our community recently asked me about GABA for sleep. They’d seen it recommended online, understood that sleep was critical for their recovery, and wanted to know whether the supplement was worth exploring or just noise. It’s a genuinely good question. And it deserves a proper answer. In this post, I’m going to walk you through what GABA is, what the clinical research actually shows about its effect on sleep, why the blood-brain barrier debate matters (and why it might not derail the whole argument), and what the evidence says about the relationship between sleep and brain recovery. By the end, you’ll have enough to have an informed conversation with your medical team. I’m not a doctor. I’m a three-time haemorrhagic stroke survivor who has spent years researching the science of brain recovery and interviewing hundreds of clinicians and survivors on the Recovery After Stroke podcast. What I offer is a careful read of the evidence, not a clinical prescription. What Is GABA and Why Does It Matter for Sleep? GABA (gamma-aminobutyric acid) is the brain’s primary inhibitory neurotransmitter. If your nervous system were a car, GABA is the brake pedal. It reduces neuronal excitability, quiets cortical arousal, suppresses the brain’s primary arousal centre (the locus coeruleus), and modulates the HPA axis, the stress-response system that drives cortisol. Most sedative medications work by amplifying GABA activity. Benzodiazepines, for instance, bind to GABA-A receptors to increase chloride channel opening, producing their calming effect. GABA isn’t doing something unusual here – it’s doing something fundamental. The question with supplemental oral GABA is more specific: Does taking GABA as a capsule or powder actually produce meaningful neurological effects? What Does the Research Show? Finding 1 — Oral GABA Reduces Sleep Latency (and EEG Can Measure It) A 2015 clinical trial published in the Journal of Nutritional Science and Vitaminology by Yamatsu and colleagues used EEG measurement, actual brainwave monitoring, rather than self-reported sleep questionnaires. One hundred milligrams of oral GABA shortened sleep latency (time to fall asleep) by 5.3 minutes compared to placebo. That might sound modest. But for someone lying awake for 30–40 minutes each night, it’s a meaningful shift. Crucially, this was objective neurophysiological data, not a survey response. (PMID: 26052150) Finding 2 — A 90-Day RCT Showed Improved Sleep Efficiency and Mood A 2024 randomised double-blind placebo-controlled trial published in the Journal of Dietary Supplements (Guimarães et al.) gave 200 mg of GABA daily for 90 days to sedentary overweight women also undergoing an exercise program. The GABA group showed significantly improved Pittsburgh Sleep Quality Index (PSQI) scores, significantly reduced depression scores, and improved heart rate variability, a marker of parasympathetic nervous system activity. The HRV finding is particularly interesting. It suggests GABA may be doing something broader than simply reducing sleep latency – it appears to support the overall physiological state that makes rest restorative. (PMID: 38321713) Finding 3 — But a High-Dose RCT Found No Effect Here’s where intellectual honesty matters. A 2023 Dutch RCT (de Bie et al.) published in the American Journal of Clinical Nutrition gave participants 500 mg of GABA three times daily, 1,500 mg/day total, and found no significant effect on self-reported sleep quality. Fasting plasma GABA wasn’t significantly elevated either, raising real bioavailability questions at that dose. This isn’t a reason to dismiss GABA entirely. It is a reason to pay attention to the dose. The evidence base supports 100–300 mg, not 1,500 mg. Higher is not better, and the non-linear dose response is clinically important. (PMID: 37495019) The Blood-Brain Barrier Debate — and Why the Gut May Be the Point The most common objection to oral GABA supplementation is this: GABA is a zwitterion at physiological pH, meaning it has low lipophilicity and poor predicted ability to cross the blood-brain barrier via passive diffusion. So if it can’t get into the brain directly, how does it produce neurological effects? The emerging explanation involves the gut-brain axis. The enteric nervous system, your gut’s own neural network, has GABA receptors. When oral GABA activates these enteric receptors, it can signal the brain via vagal afferents without needing to cross the BBB at all. Think of it as a side door rather than the front entrance. Supporting this: a 2024 RCT (Li et al.) found that a probiotic strain engineered to increase gut GABA production significantly improved objective sleep duration as measured by wearable devices, alongside reduced cortisol and suppressed HPA axis activity. The mechanism wasn’t direct CNS access – it was gut-brain signalling. (PMID: 39385735) The BBB debate doesn’t negate the clinical effect. It changes how we understand the mechanism. Why Sleep Is Not Optional in Brain Recovery This is the part that I think gets underweighted in recovery conversations — and the research is unambiguous. A 2026 large retrospective cohort study (Muhtar et al., Sleep Medicine) matched over 35,000 stroke patients and found that post-stroke insomnia was associated with a 29% higher risk of post-stroke cognitive impairment and a 30% higher risk of all-cause dementia. The association with Alzheimer’s disease was also significant. (PMID: 41924789) A 2024 observational study from Monash University and Alfred Health (Smith et al.) found that in stroke rehabilitation patients, poor sleep quality was significantly associated with higher fatigue severity and lower salivary BDNF gene expression. BDNF (brain-derived neurotrophic factor) is one of the primary molecular drivers of neuroplasticity. Less BDNF means a less receptive environment for the neurological rewiring that rehab is trying to build. (PMID: 38802847) And then there’s the glymphatic system: the brain’s waste-clearance mechanism that is most active during deep sleep. Poor sleep means reduced clearance of metabolic byproducts, including proteins associated with neurodegeneration. This is not a theoretical risk. It is an active, ongoing process. Sleep is not passive recovery. It is one of the primary mechanisms of recovery. What to Do With This Information Here are three practical steps if you’re exploring GABA for sleep: 1. Measure your sleep baseline first. Use the Pittsburgh Sleep Quality Index (freely available online) before you make any changes. Understanding whether you’re struggling with latency, duration, or quality will determine what you actually need to address. 2. If you trial GABA, choose the right form and dose. Look for PharmaGABA — naturally fermented GABA, derived from Lactobacillus hilgardii, which has the strongest clinical evidence base. A dose of 100–300 mg taken 30–60 minutes before bed is consistent with the positive studies. Avoid very high doses; the null result at 1,500 mg/day is important context. Important drug interaction note: If you are taking benzodiazepines, anticonvulsants (gabapentin, pregabalin, valproate), or any other GABAergic medication, discuss GABA supplementation with your prescriber before adding it. The additive sedative effect is a real risk. The same applies if you drink alcohol regularly. 3. Don’t skip the foundation. Sleep hygiene interventions, consistent sleep and wake times, a dark and cool room, and no screens in the 60 minutes before bed, are consistently among the highest-leverage sleep interventions in the literature. GABA may provide a genuine incremental benefit. But it cannot compensate for a fundamentally disrupted sleep environment. The Bottom Line The evidence for GABA and sleep is more substantive than I expected when I started researching it. The EEG data is real. The 90-day RCT showed meaningful clinical outcomes. The gut-brain axis mechanism is biologically plausible and now has direct RCT support. And the consequences of poor sleep in neurological recovery are not trivial – they are quantifiable, significant, and, to a degree, addressable. GABA is not a guaranteed fix. Individual responses vary. The research is not yet definitive at the level of large multi-centre trials in neurological populations. But as one tool in a comprehensive approach to sleep quality alongside good sleep hygiene, appropriate medical support, and consistent rehabilitation, the case for cautious exploration is reasonable. The next step is a conversation with your neurologist, GP, or rehab physician. Take the research with you if it’s useful. Research References All studies cited in this post are retrievable via PubMed: Yamatsu et al. — GABA sleep latency EEG clinical trial (2015) — PMID: 26052150 Guimarães et al. — GABA 200mg RCT, sleep efficiency + mood (2024) — PMID: 38321713 de Bie et al. — GABA high-dose RCT, null sleep result (2023) — PMID: 37495019 Li et al. — Gut-brain GABA axis and sleep RCT (2024) — PMID: 39385735 Muhtar et al. — Post-stroke insomnia and cognitive decline cohort (2026) — PMID: 41924789 Smith et al. — Sleep, BDNF, and fatigue in stroke rehabilitation (2024) — PMID: 38802847 This post is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional before making changes to your supplementation or treatment plan. If you or someone you care about is recovering from a stroke, brain injury, or any neurological condition, the Recovery After Stroke podcast and this blog exist for you. Subscribe on YouTube @BillGasiamis, or visit Recovery After Stroke to find episodes, resources, and community. The post GABA, Sleep, and Brain Health – Neurological Recovery appeared first on Recovery After Stroke.

In this Mini Mikkipedia episode, Mikki breaks down one of the most persistent nutrition debates: are high-protein diets actually harmful? Drawing on a recent perspective paper published in the American Journal of Clinical Nutrition, she unpacks common claims around kidney damage, bone loss, diabetes risk, and reduced longevity. Rather than dismissing concerns outright, Mikki walks through what the research truly shows, highlighting key methodological flaws, the limits of observational data, and the importance of context. From overfeeding studies to real-world dietary patterns, this episode challenges headline-driven narratives and brings nuance back into the conversation. If you've ever questioned whether your protein intake is “too high,” this is a grounded, evidence-informed discussion to help you cut through the noise and make more confident decisions.Highlights: Why the “protein turns to fat” claim doesn't hold up in real-world studies  The truth about protein intake and kidney health in healthy individuals  How higher protein diets impact bone density and fracture risk  The nuance behind protein, insulin resistance, and type 2 diabetes  Why observational data often misleads protein-related health claims Contact Mikki:https://mikkiwilliden.com/https://www.facebook.com/mikkiwillidennutritionhttps://www.instagram.com/mikkiwilliden/https://linktr.ee/mikkiwillidenNZ listeners - save 10% off Calocurb by using the code Mikkipedia10 at www.calocurb.co.nzSave 20% on all Nuzest Products WORLDWIDE with the code MIKKI at www.nuzest.co.nz, www.nuzest.com.au or www.nuzest.comCurranz supplement: MIKKI saves you 25% at www.curranz.co.nz or www.curranz.co.uk off your first order

Entzündungen gelten oft als etwas Schlechtes – aber ganz so einfach ist es nicht. In dieser Folge sprechen wir darüber, was eine Entzündungsreaktion im Körper überhaupt ist. Außerdem schauen wir uns an, welche Rolle Ernährung dabei spielt: Welche Ernährungsmuster wirken eher antientzündlich?  Zum Schluss geht es um eine spannende Frage für Sportler:innen: Kann eine antientzündliche Ernährung die Regeneration verbessern – oder blockieren wir damit vielleicht sogar wichtige Trainingsanpassungen?  ------------------------------------------------------------------------ Dominiks Buch zur pflanzenbasierten Sporternährung im UTB-Verlag: https://www.utb.de/doi/book/10.36198/9783838560328 Dominiks Gesundheitscommunity: www.gsundes-hannover.de Dominiks Online-Knie-Kurs: https://gsundes-hannover.de/knieschmerzen/ Dominiks Online-Rücken-Kurs: https://copecart.com/products/34bd5abb/checkout Marcs veganes Online-Fitness-Coaching: https://vegainer-academy.com/ Marcs Online-Kurs: https://www.copecart.com/products/a50f88f2/checkout ------------------------------------------------------------------------ Dieser Podcast wird unterstützt von der Firma Watson Nutrition. Die Firma bietet als einzige umfassend laborgeprüfte Nahrungsergänzungsmittel für eine optimierte Nährstoffversorgung. Zum Angebot zählen Multi-Supplemente, Mono-Supplemente, Sportsupplemente wie Kreatin oder auch Proteinriegel, Shakes und essenzielle Aminosäuren Mit dem Code veganperformance erhältst du 5 % Rabatt auf deine Bestellung.  Zur Firmenwebseite: Watson Nutrition ------------------------------------------------------------------------ Quellen: Hier sind alle bisher genutzten Quellen im APA-Standard, ohne DOI und ohne Link: Bell, L., Gibbs, J., & Cappuccio, F. P. (2026). The effect of plant-based dietary patterns on C-reactive protein: A systematic review and meta-analysis of randomised controlled trials, L., & Sayers, S. P. (2006). Efficacy of a tart cherry juice blend in preventing the symptoms of muscle damage. British Journal of Sports Medicine, 40(8), 679–683. Dehghani, E., Beba, M., Danandeh, K., Memari, A., Ershadmanesh, M. J., Rasoulian, P., Danandeh, A., & Djafarian, K. (2025). The effect of tart cherry juice supplementation on exercise-induced muscle damage in an athletic population: A systematic review and meta-analysis. Annals of Medicine and Surgery, 87(2). Estruch, R., Sacanella, E., & Ros, E. (2010). Anti-inflammatory effects of the Mediterranean diet: The experience of the PREDIMED study. Proceedings of the Nutrition Society, 69(3), 333–340. European Food Safety Authority. (2012). EFSA assesses safety of long-chain omega-3 fatty acids. European Food Safety Authority. Fernandes, J., Fialho, M., Santos, R., Peixoto-Plácido, C., Madeira, T., Sousa-Santos, N., Virgolino, A., Santos, O., & Vaz Carneiro, A. (2020). Is olive oil good for you? A systematic review and meta-analysis on anti-inflammatory benefits from regular dietary intake. Nutrition, 69, 110559. Hannoodee, S., & Nasuruddin, D. N. (2024). Acute inflammatory response. In StatPearls. StatPearls Publishing. Hébert, J. R., Shivappa, N., Wirth, M. D., Hussey, J. R., & Hurley, T. G. (2019). Perspective: The Dietary Inflammatory Index (DII)—Lessons learned, improvements made, and future directions. Advances in Nutrition, 10(2), 185–195. Kavyani, Z., Musazadeh, V., Fathi, S., Faghfouri, A. H., Dehghan, P., & Sarmadi, B. (2022). Efficacy of the omega-3 fatty acids supplementation on inflammatory biomarkers: An umbrella meta-analysis. International Immunopharmacology, 111, 109104. Khanna, D., Khanna, S., Khanna, P., Kahar, P., & Patel, B. M. (2022). Obesity: A chronic low-grade inflammation and its markers. Cureus, 14(2), e22711. Li, J., Lee, D. H., Hu, J., Tabung, F. K., Li, Y., Bhupathiraju, S. N., Rimm, E. B., Rexrode, K. M., Manson, J. E., Willett, W. C., Giovannucci, E. L., & Hu, F. B. (2020). Dietary inflammatory potential and risk of cardiovascular disease among men and women in the U.S. Journal of the American College of Cardiology, 76(19), 2181–2193. Liu, F.-H., Liu, C., Gong, T.-T., Gao, S., Sun, H., Jiang, Y.-T., Zhang, J.-Y., Zhang, M., Gao, C., Li, X.-Y., Zhao, Y.-H., & Wu, Q.-J. (2021). Dietary inflammatory index and health outcomes: An umbrella review of systematic review and meta-analyses of observational studies. Frontiers in Nutrition, 8, 647122. Marx, W., Veronese, N., Kelly, J. T., Smith, L., Hockey, M., Collins, S., Trakman, G. L., Hoare, E., Teasdale, S. B., Wade, A., Lane, M., Aslam, H., Davis, J. A., O'Neil, A., Shivappa, N., Hébert, J. R., Blekkenhorst, L. C., Berk, M., Segasby, T., & Jacka, F. (2021). The Dietary Inflammatory Index and human health: An umbrella review of meta-analyses of observational studies. Advances in Nutrition, 12(5), 1681–1690. Menzel, J., Jabakhanji, A., Biemann, R., Mai, K., Abraham, K., & Weikert, C. (2020). Systematic review and meta-analysis of the associations of vegan and vegetarian diets with inflammatory biomarkers. Scientific Reports, 10, 21736. Morvaridzadeh, M., Fazelian, S., Agah, S., Khazdouz, M., Rahimlou, M., Agh, F., Potter, E., Heshmati, J., & Heshmati, S. (2020). Effect of ginger (Zingiber officinale) on inflammatory markers: A systematic review and meta-analysis of randomized controlled trials. Cytokine, 135, 155224. National Institutes of Health, Office of Dietary Supplements. (2021). Vitamin E: Fact sheet for health professionals. National Institutes of Health, Office of Dietary Supplements. (2025). Omega-3 fatty acids: Fact sheet for health professionals. National Institutes of Health, Office of Dietary Supplements. (2025). Vitamin C: Fact sheet for health professionals. Ortega, D. R., López, A. M., Amaya, H. M., & Berral de la Rosa, F. J. (2021). Tart cherry and pomegranate supplementations enhance recovery from exercise-induced muscle damage: A systematic review. Biology of Sport, 38(1), 97–111. Pahwa, R., Goyal, A., & Jialal, I. (2023). Chronic inflammation. In StatPearls. StatPearls Publishing. Paulsen, G., Cumming, K. T., Holden, G., Hallén, J., Rønnestad, B. R., Sveen, O., Skaug, A., Paur, I., Bastani, N. E., Østgaard, H. N., Buer, C., Midttun, M., Freuchen, F., Wiig, H., Ulseth, E. T., Garthe, I., Blomhoff, R., Benestad, H. B., & Raastad, T. (2014). Vitamin C and E supplementation hampers cellular adaptation to endurance training in humans: A double-blind, randomized, controlled trial. The Journal of Physiology, 592(8), 1887–1901. Paulsen, G., Hamarsland, H., Cumming, K. T., Johansen, R. E., Hulmi, J. J., Børsheim, E., Wiig, H., Garthe, I., & Raastad, T. (2014). Vitamin C and E supplementation alters protein signalling after a strength training session, but not muscle growth during 10 weeks of training. The Journal of Physiology, 592(24), 5391–5408. Pearson, A. G., Hind, K., & Macnaughton, L. S. (2023). The impact of dietary protein supplementation on recovery from resistance exercise-induced muscle damage: A systematic review with meta-analysis. European Journal of Clinical Nutrition, 77, 767–783. Ristow, M., Zarse, K., Oberbach, A., Klöting, N., Birringer, M., Kiehntopf, M., Stumvoll, M., Kahn, C. R., & Blüher, M. (2009). Antioxidants prevent health-promoting effects of physical exercise in humans. Proceedings of the National Academy of Sciences of the United States of America, 106(21), 8665–8670. Rojano-Ortega, D., Peña Amaro, J., Berral-Aguilar, A. J., & Berral-de la Rosa, F. J. (2022). Effects of beetroot supplementation on recovery after exercise-induced muscle damage: A systematic review. Sports Health, 14(4), 556–565. Shivappa, N., Steck, S. E., Hurley, T. G., Hussey, J. R., & Hébert, J. R. (2014). Designing and developing a literature-derived, population-based dietary inflammatory index. Public Health Nutrition, 17(8), 1689–1696. Song, W., Wang, J., Wang, H., & Li, Y. (2023). Anthocyanin supplementation improves obesity-related inflammatory characteristics: A systematic review and meta-analysis of randomized controlled trials. Nutrition Reviews, 82(1), 57–70. Tabrizi, R., Vakili, S., Lankarani, K. B., Akbari, M., Mirhosseini, N., Ghayour-Mobarhan, M., Ferns, G., Taghizadeh, M., Asemi, Z., & others. (2019). The effects of curcumin-containing supplements on biomarkers of inflammation and oxidative stress: A systematic review and meta-analysis of randomized controlled trials. Phytotherapy Research, 33(2), 253–262. Tabung, F. K., Steck, S. E., Zhang, J., Ma, Y., Liese, A. D., Agalliu, I., Hingle, M., Hou, L., Hurley, T. G., Jiao, L., Martin, L. W., Millen, A. E., Park, H. L., Rosal, M. C., Shikany, J. M., Shivappa, N., Ockene, J. K., & Hébert, J. R. (2015). Construct validation of the Dietary Inflammatory Index among postmenopausal women. Annals of Epidemiology, 25(6), 398–405. Tarazona-Díaz, M. P., Alacid, F., Carrasco, M., Martínez, I., & Aguayo, E. (2013). Watermelon juice: Potential functional drink for sore muscle relief in athletes. Journal of Agricultural and Food Chemistry, 61(31), 7522–7528. Trombold, J. R., Reinfeld, A. S., Casler, J. R., & Coyle, E. F. (2011). The effect of pomegranate juice supplementation on strength and soreness after eccentric exercise. Journal of Strength and Conditioning Research, 25(7), 1782–1788. Vinelli, V., Biscotti, P., Martini, D., Del Bo', C., Marino, M., Meroño, T., Nikoloudaki, O., Calabrese, F. M., Turroni, S., & Riso, P. (2022). Effects of dietary fibers on short-chain fatty acids and gut microbiota composition in healthy adults: A systematic review. Nutrients, 14(13), 2559. Yu, Y., Tian, L., Xiao, Y., Huang, G., & Zhang, M. (2018). Effect of vitamin D supplementation on some inflammatory biomarkers in type 2 diabetes mellitus subjects: A systematic review and meta-analysis of randomized controlled trials. Annals of Nutrition and Metabolism, 73(1), 62–73. Yu, Z., Malik, V. S., Keum, N., Hu, F. B., Giovannucci, E. L., Stampfer, M. J., Willett, W. C., & Fuchs, C. S. (2016). Associations between nut consumption and inflammatory biomarkers. The American Journal of Clinical Nutrition, 104(3), 722–728.    

862. Can you actually "reset" your taste buds by cutting out sugar? You've heard that a 30-day sugar detox will make your cravings disappear, but a new study in the American Journal of Clinical Nutrition suggests our preference for sweetness is more permanent than we thought. This week, Monica debunks the "palate reset" myth and explores a more effective way to manage a sweet tooth.Key Takeaways:The myth of the palate reset: Why "The Sweet Tooth Trial" found that cutting sugar for 6 months didn't change taste preferences.The first 1,000 days: How early life exposure sets your biological "sweetness" baseline.Behavior over biology: Why addressing emotional triggers is more effective than a 30-day cleanse.Nutrition Diva is a Quick and Dirty Tips podcast, hosted by Monica Reinegal.New to Nutrition Diva? Check out our special Spotify playlist for a collection of the best episodes curated by our team and Monica herself! We've also curated some great playlists on specific episode topics including Staying Strong as We Age, Diabetes, Weight Loss That Lasts and Gut Health! Also, find a playlist of our bone health series, Stronger Bones at Every Age. Have a question for Nutrition Diva? Email: nutrition@quickanddirtytips.comDiscover more from Nutrition Diva:Facebook LinkedInNewsletterTranscripts available at QuickandDirtyTips.com. Hosted on Acast. See acast.com/privacy for more information.

From reversing fatty liver in children to understanding LDL and HDL, Dr. Marbas uses case studies to show the power of plant-based diets. #LiverHealth #Cholesterol #HeartHealth #NutritionStories

What if every time you reached for a packaged snack… you were quietly increasing your risk of a heart attack? In this urgent and deeply personal solo episode, Darin breaks down groundbreaking new research showing that each serving of ultra-processed food may increase cardiovascular risk by over 5%, not over time, but every single time you eat it. This isn't about calories. It's about chemistry, biology, and a system engineered for convenience at the expense of your health. From the shocking data to the underlying mechanisms: gut destruction, visceral fat accumulation, brain hijacking, and toxic exposure, this episode exposes the real cost of ultra-processed food and gives you the tools to reclaim control of your health and your life. What You'll Learn The shocking stat: 5% increased heart risk per serving of ultra-processed food Why ultra-processed foods act like compounding debt on your health The difference between calories vs chemical toxicity in food How emulsifiers and additives destroy your gut microbiome Why ultra-processed foods increase visceral fat around your organs How these foods are engineered to override your brain's satiety signals The hidden toxins from processing and packaging (PFAS, bisphenols, AGEs) Why this crisis disproportionately impacts certain communities The truth: you can't "out-exercise" ultra-processed food damage Practical ways to transition back to real, whole foods Chapters 00:00:04 – Opening: SuperLife mission and setting the stage 00:00:33 – Sponsor: Alkemis Paint and hidden indoor toxicity 00:01:24 – Why conventional paints off-gas harmful chemicals for years 00:02:27 – Cradle-to-Cradle certification and non-toxic living 00:03:24 – Entering the episode: the 5% heart risk question 00:03:34 – The shocking claim: every serving increases heart risk 00:04:16 – Ultra-processed food as "compounding debt" 00:05:08 – Leaning into discomfort as a path to growth 00:06:33 – The convenience trap: food delivered instantly 00:07:15 – The real cost: trading time for lifespan 00:08:07 – 2026 study overview (MESA dataset, 6,800 participants) 00:09:01 – 5.1% increased cardiovascular risk per serving explained 00:09:29 – 66.8% higher risk in high-consumption groups 00:10:08 – Risk is independent of calories, weight, and fitness 00:10:56 – "This is not a calorie story—it's a chemistry story" 00:11:10 – Racial disparities and food system inequality 00:12:08 – Additional studies confirm elevated heart risk 00:13:04 – Global meta-analysis: over 1 million participants 00:13:26 – The conclusion: the science is no longer debatable 00:14:18 – Sponsor: Shakeology and nutrient density 00:15:36 – What is ultra-processed food? (NOVA classification) 00:16:18 – Examples: chips, cereals, protein bars, fast food 00:16:57 – "These foods are engineered—not real food" 00:17:00 – Mechanism #1: gut microbiome disruption 00:18:03 – Emulsifiers and inflammation explained 00:18:49 – Gut inflammation triggers systemic disease 00:19:18 – Mechanism #2: visceral fat accumulation 00:19:56 – Why visceral fat is more dangerous than visible fat 00:20:18 – Mechanism #3: brain hijacking and satiety override 00:20:47 – Engineered foods and addictive eating patterns 00:21:04 – Mechanism #4: toxins from processing and packaging 00:21:30 – PFAS, bisphenols, and chemical contamination 00:21:37 – The solution: whole food first 00:22:02 – Breaking habits and reclaiming control 00:22:20 – Simple swaps: fruit, nuts, whole ingredients 00:23:00 – "If you can't trace it back to a real food, put it down" 00:23:32 – Making whole food convenient 00:24:06 – Batch cooking and preparation strategies 00:24:16 – Personal story: losing a friend to diet-related illness 00:24:40 – The emotional reality: this is life or death 00:25:00 – Community support and accountability 00:25:25 – Call to action: share this message 00:25:41 – Closing: courage, awareness, and living a SuperLife 00:26:23 – Outro Thank You to Our Sponsors: Shakeology: Get 15% off with code DARINO1BODI at Shakeology.com. Alkemis Paint: Go to https://alkemispaint.com/ and use code DARIN10 for 10% off your order. Join the SuperLife Patreon: This is where Darin now shares the deeper work: - weekly voice notes - ingredient trackers - wellness challenges - extended conversations - community accountability - sovereignty practices Join now for only $7.49/month at https://patreon.com/darinolien Connect with Darin Olien: Website: darinolien.com Instagram: @darinolien Book: Fatal Conveniences Platform & Products: superlife.com New Show: Roadmap to Happiness Key Takeaway "Every time you reach for ultra-processed food, you're not just making a small decision—you're compounding a biological cost that your body has to pay later. But the moment you become aware, you reclaim your power. Because the same way those choices can slowly take your health away… different choices, repeated daily, can give it all back." Bibliography/Sources Primary Study — News Hook Haidar, A., Rikhi, R., Watson, K. E., Wood, A. C., & Shapiro, M. D. (2026). Association between ultraprocessed food consumption and cardiovascular disease risk: MESA. JACC: Advances. https://doi.org/10.1016/j.jacadv.2025.102516 Supporting Studies — 2026 Willett, Y., Yang, C., Dunn, J., et al. (2026). Consumption of ultra-processed foods and increased risks of cardiovascular disease in U.S. adults. The American Journal of Medicine. https://doi.org/10.1016/j.amjmed.2026.01.012 Systematic Reviews & Meta-Analyses Dose-response meta-analysis: UPF consumption and cardiovascular events risk — 20 studies, 1.1M participants. (2024). eClinicalMedicine. https://doi.org/10.1016/j.eclinm.2024.102480 Ultra-processed foods and cardiovascular disease: Analysis of three large US prospective cohorts and a systematic review and meta-analysis. (2024). The Lancet Regional Health – Americas. https://www.thelancet.com/journals/lanam/article/PIIS2667-193X(24)00186-8/fulltext Mechanisms — Gut, Inflammation & Additives Ultra-processed foods and cardiovascular diseases: Potential mechanisms of action. (2021). Advances in Nutrition. https://pmc.ncbi.nlm.nih.gov/articles/PMC8483964/ Ultra-processed foods and food additives in gut health and disease. (2024). Nature Reviews. https://pubmed.ncbi.nlm.nih.gov/38388570/ Ultra-processed foods and incident cardiovascular disease in the Framingham Offspring Study. (2021). Journal of the American College of Cardiology. https://doi.org/10.1016/j.jacc.2021.01.047 Ultraprocessed foods and their association with cardiometabolic health: A science advisory from the American Heart Association. (2023). Circulation. https://www.ahajournals.org/doi/10.1161/CIR.0000000000001365 Visceral Fat Konieczna, J., et al. (n.d.). Contribution of ultra-processed foods in visceral fat deposition: Prospective analysis nested in the PREDIMED-Plus trial. Clinical Nutrition. https://www.explorationpub.com/Journals/edd/Article/100523 NOVA Classification Monteiro, C. A., Cannon, G., Levy, R. B., et al. (2019). Ultra-processed foods: What they are and how to identify them. Public Health Nutrition, 22(5), 936–941. https://pubmed.ncbi.nlm.nih.gov/30744710/ Policy & Public Health Context American College of Cardiology. (2025). ACC 2025 concise clinical guidance: Front-of-package labeling endorsement. Journal of the American College of Cardiology. U.S. Departments of Agriculture and Health and Human Services. (n.d.). Dietary guidelines for Americans, 2025–2030. https://www.dietaryguidelines.gov General Coverage — News Hook Food Safety Magazine. (2026, April). Study links diets high in ultra-processed foods to increased heart attack, stroke risk. https://www.food-safety.com/articles/11290-study-links-diets-high-in-ultra-processed-foods-to-increased-heart-attack-stroke-risk ScienceDaily. (2026, March). Ultra-processed foods linked to 67% higher risk of heart attack and stroke. https://www.sciencedaily.com/releases/2026/03/260319074604.htm

Join host Graham McMahon, president and CEO of ACCME, as he speaks with registered dietitian Colleen Tewksbury, PhD, MPH, RD, CSOWM, LDN, FAND, incoming Chair of the Commission on Dietetic Registration and Assistant Professor in Nutrition Science at University of Pennsylvania, and pediatrician Christopher Duggan, MD, MPH, Editor in Chief, The American Journal of Clinical Nutrition, and Professor of Nutrition, Harvard University. They discuss evidence-based nutrition care, communicating without stigma, and practical ways interprofessional teams can help patients make sustainable changes amid widespread misinformation. Listen now and share with colleagues who are committed to strengthening nutrition and prevention in everyday practice.

Woran merkst du eigentlich, dass du zu wenig isst? In dieser Folge sprechen wir darüber, warum eine zu geringe Energiezufuhr oft lange unbemerkt bleibt und sich nicht nur über Hunger oder Gewichtsverlust zeigt. Es geht um typische körperliche und mentale Warnsignale, Veränderungen im Training, hormonelle und metabolische Folgen sowie die Frage, warum „gesund essen“ nicht automatisch bedeutet, dass der Körper auch wirklich ausreichend versorgt ist. Außerdem besprechen wir, welche Gruppen besonders gefährdet sind, wie du Unterversorgung im Alltag erkennen und was du konkret tun kannst, wenn du den Verdacht hast, dauerhaft zu wenig zu essen. ------------------------------------------------------------------------ Dominiks Buch zur pflanzenbasierten Sporternährung im UTB-Verlag: https://www.utb.de/doi/book/10.36198/9783838560328 Dominiks Gesundheitscommunity: www.gsundes-hannover.de Dominiks Online-Knie-Kurs: https://gsundes-hannover.de/knieschmerzen/ Dominiks Online-Rücken-Kurs: https://copecart.com/products/34bd5abb/checkout Marcs veganes Online-Fitness-Coaching: https://vegainer-academy.com/ Marcs Online-Kurs: https://www.copecart.com/products/a50f88f2/checkout ------------------------------------------------------------------------ Dieser Podcast wird unterstützt von der Firma Watson Nutrition. Die Firma bietet als einzige umfassend laborgeprüfte Nahrungsergänzungsmittel für eine optimierte Nährstoffversorgung. Zum Angebot zählen Multi-Supplemente, Mono-Supplemente, Sportsupplemente wie Kreatin oder auch Proteinriegel, Shakes und essenzielle Aminosäuren Mit dem Code veganperformance erhältst du 5 % Rabatt auf deine Bestellung.  Zur Firmenwebseite: Watson Nutrition ------------------------------------------------------------------------ Quellen: Fahrenholtz, I. L., Sjödin, A., Benardot, D., Tornberg, Å. B., Skouby, S. O., Faber, J., Sundgot-Borgen, J. K., & Melin, A. K. (2018). Within-day energy deficiency and reproductive function in female endurance athletes. Scandinavian Journal of Medicine & Science in Sports, 28(3), 1139–1146. Ihle, R., & Loucks, A. B. (2004). Dose-response relationships between energy availability and bone turnover in young exercising women. Journal of Bone and Mineral Research, 19(8), 1231–1240. Lieberman, H. R., Bukhari, A. S., Caldwell, J. A., Wilson, M. A., Mahoney, C. R., Pasiakos, S. M., McClung, J. P., & Smith, T. J. (2017). Two days of calorie deprivation induced by underfeeding and aerobic exercise degrades mood and lowers interstitial glucose but does not impair cognitive function in young adults. The Journal of Nutrition, 147(1), 110–116. Longland, T. M., Oikawa, S. Y., Mitchell, C. J., Devries, M. C., & Phillips, S. M. (2016). Higher compared with lower dietary protein during an energy deficit combined with intense exercise promotes greater lean mass gain and fat mass loss: A randomized trial. The American Journal of Clinical Nutrition, 103(3), 738–746. Loucks, A. B., & Thuma, J. R. (2003). Luteinizing hormone pulsatility is disrupted at a threshold of energy availability in regularly menstruating women. The Journal of Clinical Endocrinology & Metabolism, 88(1), 297–311. Loucks, A. B., Verdun, M., & Heath, E. M. (1998). Low energy availability, not stress of exercise, alters LH pulsatility in exercising women. Journal of Applied Physiology, 84(1), 37–46. Melin, A. K., Tornberg, Å. B., Skouby, S. O., Møller, S. S., Sundgot-Borgen, J., Faber, J., Sidelmann, J. J., Aziz, M., & Sjödin, A. M. (2015). Energy availability and the female athlete triad in elite endurance athletes. Scandinavian Journal of Medicine & Science in Sports, 25(5), 610–622. Mettler, S., Mitchell, N., & Tipton, K. D. (2010). Increased protein intake reduces lean body mass loss during weight loss in athletes. Medicine & Science in Sports & Exercise, 42(2), 326–337. Murphy, C., Bilek, L. D., & Koehler, K. (2021). Low energy availability with and without a high-protein diet suppresses bone formation and increases bone resorption in men: A randomized controlled pilot study. Nutrients, 13(3), 802. Murphy, C., & Koehler, K. (2020). Caloric restriction induces anabolic resistance to resistance exercise. European Journal of Applied Physiology, 120(5), 1155–1164. Staal, S., Sjödin, A. M., Fahrenholtz, I. L., Bonnesen, K., & Melin, A. K. (2018). Low RMR ratio as a surrogate marker for energy deficiency, the choice of predictive equation vital for correctly identifying male and female ballet dancers at risk. International Journal of Sport Nutrition and Exercise Metabolism, 28(4), 412–418. Torstveit, M. K., Fahrenholtz, I., Stenqvist, T. B., Sylta, Ø., & Melin, A. (2018). Within-day energy deficiency and metabolic perturbation in male endurance athletes. International Journal of Sport Nutrition and Exercise Metabolism, 28(4), 419–427.    

Sleep issues are a BIG deal—just ask someone who's been up all night involuntarily. More than half of all Americans have difficulty falling or staying asleep. Good sleep is critical for "Keeping the 'Live' in 'Alive'!   I had a 'Random Run In' with Dr. Marie-Pierre St-Onge, PhD, a nutrition scientist and a pioneer in the field of sleep health. I was on an Amtrak to Boston, and I happened to choose the seat next to her. She was working diligently on her computer. I kept sneaking peaks at the bright fun patterned shirt she was wearing that I finally figured out reminded me of my old Peter Max stationery I loved so much as a kid. She was focused so I was quiet. At some point during the 3 ½ hour trip I asked what she was working on. (Couldn't help it - I'm a curious stranger talker) That's how I found out I was sitting next to a very big brain wrapped in a very small feminine body. Dr. Marie-Pierre St-Onge PhD is THE 'go-to' expert on the connection between food and sleep.   Dr. Marie-Pierre St-Onge, PhD, is a nutrition scientist and a pioneer in the field of sleep health.  She is the author of Eat Better, Sleep Better: 75 Recipes and A 28-Day Meal Plan That Unlock the Food-Sleep Connection (A Cookbook). She wrote it in a fun recipe collaboration with Kat Craddock Editor-in Chief, CEO and owner of SAVEUR the legacy food magazine. Developed with ingredients that trigger the body's dietary melatonin and serotonin, these recipes align with a Mediterranean diet and trigger a healthy circadian cycle, so you feel energetic during the day and ready for sleep at night. Dr. Marie-Pierre is also the founding director of the Center of Excellence for Sleep and Circadian Research at Columbia University, and her cutting-edge research combines her unique expertise on sleep, nutrition, and weight management to address overall health related to sleep.    The Big Takeaway for Me From Our Amtrak Conversation Was Learning That Sleep and Food Are Powerfully Connected! The way you eat affects how you sleep The way you sleep affects how you eat It's a loop… and if it's broken? You feel it.   Dr. Marie-Pierre made it simple: Better Diet = Better Sleep = Better Life And not in a "perfect eating" way… in a real-life, doable, smart swaps kind of way.   So What Should We Actually Be Eating To Sleep Better? No gimmicks here. Just smart, science-backed choices: Fiber-rich foods (hello whole grains) Healthy proteins (fish, salmon, nuts, seeds) Foods with tryptophan (the Thanksgiving turkey effect is real-ish ) Balanced meals—not heavy, late-night overloads And here's something people don't always realize Dr Marie mentioned: Alcohol may help you fall asleep… but it messes with your sleep later. And Wait… "Sweets for Sleep"? I'm Listening… Now THIS caught my attention. There are actually desserts designed to SUPPORT sleep—like: Sesame shortbread cookies Chamomile ginger panna cotta They're: Lower in sugar Thoughtfully balanced Built with ingredients that help your body relax So yes… you can have your dessert and your sleep. Just smarter.   Timing Matters More Than You Think One thing I loved learning from Dr. Marie? This isn't about a "magic bedtime snack." It's about your entire day of eating. Because your body needs time to: Digest Absorb Convert nutrients (like tryptophan into sleep-supporting compounds) This is a lifestyle—not a quick fix. But it matters.   And About Those Sleep Trackers… I had to ask. Her answer? Refreshingly sane:  Use them  Learn from them  BUT… don't let them run your life Because how you feel still matters.   My Debservation? We spend so much time chasing energy… …but we ignore the foundation of it—sleep. And if food is part of the solution? That's empowering. Because it means we have more control than we think.   Now back to Dr. Marie-Pierre I have no clue when this sleep expert has time to sleep. Lol She's a very busy woman!   Born and educated in Québec, Canada, Dr. Marie-Pierre St-Onge lives with her family in New Jersey. When I met her on Amtrak, she was working on a presentation that she was supposed to have made in person in Chicago that day. However, airplane delays landed her instead on the Amtrak to Boston where she would do the presentation virtually and still be in the right place for another yet another presentation in Boston.  Dr. Marie-Pierre St-Onge, PhD is the recipient of an Outstanding Investigator Award from the NHLBI (National Heart, Lung, and Blood Institute) at the NIH, and she is a Fulbright Scholar as well as a Fellow of the New York Academy of Medicine.  She has authored close to 170 peer-reviewed publications and received scientific achievement awards from the American Heart Association and American Society for Clinical Nutrition.   Amazing right?   But Even Sleep Experts Get Tired. I noticed after typing for hours in the seat next to me that Dr. Marie-Pierre had started to doze off.   When she woke up I offered her a sample Alert Pop™.   What are the chances?   I was on Amtrak that day heading to Boston to meet a major distributor for a new product called Alert Pop™! I'm a Founding Partner of the company behind this new 'better for you' sugar free caffeinated functional energy lollipop that was invented by my partner Stephen Caldwell to help prevent drowsy driving.    Did you know 1 in 25 drivers admit to falling asleep at the wheel? I figured Dr. Marie could appreciate the purpose of the product and told her I'd love her opinion.  She liked it! Perked her right up. I thought maybe we could somehow collaborate.   Anyway, we exchanged contacts and honestly, I felt she was way too impressive a 'random run in' to keep to myself.  So, I'm sharing her and her knowledge with you all today on my Wellness Wednesday Show.   Listen to the Full Interview If you missed it, here's my conversation with Dr. Marie-Pierre St-Onge PhD on The Debbie Nigro Show. It's packed with insights that could genuinely change how you feel every single day.   And it starts with a simple and powerful premise... What you eat today will determine how you sleep tonight.   And 'Good Sleep' is key to "Keeping the Live in Alive! "    Best! Debbie

Kristen Blake is a Functional Health Practitioner, Clinical Nutritionist, and the founder of Kristen Blake Wellness, where she helps women heal their gut, balance their hormones, and reclaim their energy through a personalized, root-cause approach to wellness. She holds a Master of Science in Clinical Nutrition and Human Performance, is a certified Integrative Nutrition Health Coach, and has advanced specialty training in gut health and hormone health. After seeing countless women dismissed by conventional care and told their symptoms were "normal," Kristen set out to change the experience of women's health. She combines functional lab testing, personalized nutrition, and evidence-based holistic strategies to help women finally feel like themselves again. Kristen is known for her clear, science-backed education on women's wellness, gut and hormone health, metabolic balance, and whole-body healing—empowering women to become the expert of their own body.   https://www.instagram.com/kristenblakewellness/ 

Plant-based diets reverse heart disease better than statins or surgeries, while meat and dairy elevate cholesterol and cancer risk. #HeartHealth #Cholesterol #PlantBasedReversal #CardiovascularCare

This is a free preview of a paid episode. To hear more, visit rethinkingwellness.substack.comRegistered nutritionist, author, and friend of the pod Laura Thomas joins us to unpack the problematic notion that you need to eat a ridiculously large number of plants per week for gut health, and what we actually know about how plant foods affect the gut microbiome. We also get into how to distinguish good science from hype, how ultra-processed foods have become so demonized despite a lack of strong evidence, how anti-fat bias is baked into the discourse about both gut health and ultra-processed foods, and lots more. Paid subscribers can hear the full interview, and the first part is available to all listeners. To upgrade to paid, go to rethinkingwellness.substack.com. Laura is a Registered Nutritionist who helps people feel less afraid of the food they eat and more comfortable in their bodies. Through her work with individuals and families, as well as in her writing, she challenges dominant ideals about ‘good' and ‘bad' foods and ‘good' and ‘bad' bodies. She holds a PhD in Nutritional Sciences from Texas A&M University, and worked as a post-doctoral research associate at Cornell University before starting her private practice. More recently she received a diploma in Clinical Nutrition and Eating Disorders from UCL. She has published two books: Just Eat It and How To Just Eat It, both of which focus on healing our relationship with food and our body through Intuitive Eating. Her clinical work is focussed on supporting families to end the intergenerational transmission of body shame and disordered eating. She writes the newsletter Can I Have Another Snack?If you like this conversation, subscribe to hear lots more like it! Support the podcast by becoming a paid subscriber, and unlock great perks like extended interviews, subscriber-only Q&As, full access to our archives, commenting privileges and subscriber threads where you can connect with other listeners, and more. Learn more and sign up at rethinkingwellness.substack.com.Christy's second book, The Wellness Trap, is available wherever books are sold! Order it here, or ask for it in your favorite local bookstore.If you're looking to make peace with food and break free from diet and wellness culture, come check out Christy's Intuitive Eating Fundamentals online course.

Intermittent fasting may help with blood sugar, appetite, fat loss, and energy. But many people do it wrong.  In this episode, Professor James Betts, one of the world's leading experts on meal timing and its metabolic effects, explains what fasting actually is, how long you need to fast to see changes, and the key mistakes that can stop the benefits. Today, we break down what happens in your body when you stop eating and explain why it may support weight loss and blood sugar control, but also why fasting doesn't work for everyone. You will learn why breakfast may not matter, why the 5:2 diet often fails, and why eating even small amounts can stop a true fast. By the end of this episode, you will understand what counts as a real fast, how long your eating window may need to be, why longer is not always better if you cannot stick to it, and why planning your first meal matters, because hunger can drive poor choices. If fasting can work, but is not magic, what actually makes the difference: the timing, the consistency, or simply eating less?

In this episode, Vanessa breaks down the fasting mimicking diet (FMD) — including the exact calories, macros, and protein intake used in the research — and compares it to higher-protein fat loss approaches like protein-sparing modified fasting (PSMF) days.

The research and real talk keep rolling in! Join Jenny and John yet again as they dive into some new revelations on vitamin D, Alzheimer's disease, and ultra-processed foods. Then, John brings the heat with an enthralling round of “Real Talk? Or Bro-Science?”Guest Name/ Guest Company / Guest or Company websiteJohn Bauer, Lionel UniversityInterview Date11/20/25Episode Title and Subtitle (i.e. Ep.0: Meet Your Hosts, Meet your co-hosts Jenny Scott and Dan Duran!)Research & Real Talk Episode 20 with GUEST John Bauer (he's baaaack!!)Episode Description- For website and podcast platformsThe research and real talk keep rolling in! Join Jenny and John yet again as they dive into some new revelations on vitamin D, Alzheimer's disease, and ultra-processed foods. Then, John brings the heat with an enthralling round of “Real Talk? Or Bro-Science?”Notes: (Links, websites, references etc) for show notesLighting Fitness Facts1. Which Fat-soluble vitamin is being researched for its anti-aging properties on a DNA level?A: Vitamin D!A new review out of Augusta University in the US is shedding light on how vitamin D—the so-called “sunshine vitamin”—may do more than just build strong bones. Researchers found that taking 2,000 IU of vitamin D daily helped preserve telomeres, the protective caps at the ends of our chromosomes that act like the plastic tips on shoelaces, keeping our DNA from fraying each time cells divide. Shorter telomeres are tied to aging and diseases like cancer and heart disease, so keeping them intact could mean healthier aging.In a five-year study of more than 1,000 adults, those who took vitamin D maintained their telomeres by about 140 base pairs more than those on a placebo—potentially slowing cellular aging. Scientists think vitamin D's anti-inflammatory effects may be key here, since inflammation accelerates telomere damage.That said, researchers caution that we still don't know the perfect dosage or whether longer telomeres always equal better health. The takeaway? Vitamin D might be one helpful piece of the healthy aging puzzle, but the best telomere protection still comes from the basics—good nutrition, regular exercise, quality sleep, and managing stress.2. As it relates to the diet, what are researchers homing in on as a primary cause of chronic systemic inflammation possibly leading to chronic health issues?A: high ultra-processed food consumptionNew research from Florida Atlantic University is sounding the alarm on ultra-processed foods—things like chips, soda, frozen meals, and processed meats that make up nearly 60% of the average adult's calories in the U.S. and almost 70% of kids' diets. These foods are packed with additives, low in nutrients, and designed to keep you eating more. The study found that people who consumed the highest amounts of ultra-processed foods had significantly higher levels of high-sensitivity C-reactive protein, or hs-CRP—a key marker of inflammation and a strong predictor of heart disease.Researchers analyzed data from over 9,000 adults across the U.S. and discovered that those getting 60 to 79% of their calories from ultra-processed foods had about an 11% higher likelihood of elevated inflammation compared to people eating the least. Even moderate consumers saw higher risk. The link was especially strong among people aged 50 to 59, those with obesity, and smokers.Inflammation is at the root of many chronic diseases—from heart problems to cancer—and the study's authors say this growing reliance on ultra-processed foods could be playing a major role. They even compare the situation to early warnings about tobacco use, predicting that it may take time and policy change before the food industry shifts. For now, the takeaway is clear: the closer your food is to its natural form—fruits, vegetables, lean proteins, and whole grains—the better for your long-term health.3. Alzheimer's research is constantly advancing and scientists think they have identified something that may be contributing to the development and progression of the disease. What do you think that may be? HINT- it is the buildup of something that is causing issues.A: Fat in the brain!Researchers at Purdue University have uncovered a surprising new clue in the fight against Alzheimer's disease—fat buildup inside the brain's immune cells may be a key driver of the disease's progression. Published in the journal Immunity, the study reveals that microglia, the brain's cleanup crew responsible for clearing toxic proteins like amyloid beta, become overloaded with fat and lose their ability to protect the brain.The team found that these fat-stuffed microglia, clustered around amyloid plaques, clear about 40% less amyloid than healthy cells. The culprit appears to be an enzyme called DGAT2, which gets stuck in overdrive and turns useful fatty acids into stored fat, clogging the microglia. When researchers blocked or degraded this enzyme in animal models, the microglia regained their function and began clearing out harmful debris again—restoring the brain's balance.This discovery marks a shift from the traditional focus on protein plaques and tangles to what scientists are calling a “lipid model” of Alzheimer's, where the buildup of certain fats—not just misfolded proteins—plays a central role in neurodegeneration. The findings open the door to a new class of therapies that target fat metabolism in the brain, potentially helping immune cells fight back against Alzheimer's and related diseases.References:1. Haidong Zhu, JoAnn E Manson, Nancy R Cook, Bayu B Bekele, Li Chen, Kevin J Kane, Ying Huang, Wenjun Li, William Christen, I-Min Lee, Yanbin Dong. Vitamin D3 and marine ω-3 fatty acids supplementation and leukocyte telomere length: 4-year findings from the VITamin D and OmegA-3 TriaL (VITAL) randomized controlled trial. The American Journal of Clinical Nutrition, 2025; 122 (1): 39 DOI: 10.1016/j.ajcnut.2025.05.0032. Kevin Sajan, Nishi Anthireddy, Alexandra Matarazzo, Caio Furtado, Charles H. Hennekens, Allison Ferris. Ultra-processed foods and increased high sensitivity C-reactive protein. The American Journal of Medicine, 2025; DOI: 10.1016/j.amjmed.2025.08.0163. Salt, Sugar, Fat by Micahel Moss4. Priya Prakash, Palak Manchanda, Evi Paouri, Kanchan Bisht, Kaushik Sharma, Jitika Rajpoot, Victoria Wendt, Ahad Hossain, Prageeth R. Wijewardhane, Caitlin E. Randolph, Yihao Chen, Sarah Stanko, Nadia Gasmi, Anxhela Gjojdeshi, Sophie Card, Jonathan Fine, Krupal P. Jethava, Matthew G. Clark, Bin Dong, Seohee Ma, Alexis Crockett, Elizabeth A. Thayer, Marlo Nicolas, Ryann Davis, Dhruv Hardikar, Daniela Allende, Richard A. Prayson, Chi Zhang, Dimitrios Davalos, Gaurav Chopra. Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer's disease. Immunity, 2025; 58 (6): 1536 DOI: 10.1016/j.immuni.2025.04.0295. Kevin A. Guttenplan, Maya K. Weigel, Priya Prakash, Prageeth R. Wijewardhane, Philip Hasel, Uriel Rufen-Blanchette, Alexandra E. Münch, Jacob A. Blum, Jonathan Fine, Mikaela C. Neal, Kimberley D. Bruce, Aaron D. Gitler, Gaurav Chopra, Shane A. Liddelow, Ben A. Barres. Neurotoxic reactive astrocytes induce cell death via saturated lipids. Nature, 2021; 599 (7883): 102 DOI: 10.1038/s41586-021-03960-y6. China N. Byrns, Alexandra E. Perlegos, Karl N. Miller, Zhecheng Jin, Faith R. Carranza, Palak Manchandra, Connor H. Beveridge, Caitlin E. Randolph, V. Sai Chaluvadi, Shirley L. Zhang, Ananth R. Srinivasan, F. C. Bennett, Amita Sehgal, Peter D. Adams, Gaurav Chopra, Nancy M. Bonini. Senescent glia link mitochondrial dysfunction and lipid accumulation. Nature, 2024; 630 (8016): 475 DOI: 10.1038/s41586-024-07516-8

This episode is sponsored by LMNT. LMNT - Get a free 8-count Sample Pack of LMNT's most popular drink mix flavors with any purchase at https://drinklmnt.com/FLIPPING50. Connect with Flipping 50: Facebook Group - Flipping50 Insiders Instagram - @Flipping50TV YouTube - @Flipping50TV More Episodes - Flipping 50 The Stronger Way References: The Journal of Clinical Endocrinology and Metabolism. 2007, PMID: 17200169. The American Journal of Clinical Nutrition. 2009, PMID: 19056590. Nutrients. 2021, PMID: 33652669. Front Public Health. 2026, PMID: 41668861. Sleep Medicine Clinics. 2018, PMID: 30098758. The American Journal of Clinical Nutrition. 2016, PMID: 27385608. BMC Women's Health. 2013, PMID: 24228934. Other Episodes You Might Like: Previous Episode - GLP-1 Medications for Weight Loss: A 42-Year Fitness Professional's Honest Take Next Episode - Beyond Hot Flashes: How Heat Impacts Health & Longevity More Like This - Does Hormonal Phase and Training Intensity Change How Hard You Can Train? New Science Finally Tested It Resources: Don't know where to start? Book your Discovery Call with Debra. Leave this session with insight into exactly what to do right now to make small changes, smart decisions about your exercise time and energy. Use Flipping 50 Scorecard & Guide to measure what matters with an easy at-home self-assessment test you can do in minutes. This episode breaks down the science-backed mistakes sabotaging your metabolism, especially for women in perimenopause and postmenopause. You're eating less. You're moving more. You're trying to “be disciplined.” And your metabolism? Slower. Hungrier. More stubborn. I'm giving you the 6 common strategies to lose weight that are hurting your metabolism in menopause — with real data on muscle loss, metabolic adaptation, sleep disruption, and hormone shifts. No fear mongering tactics. No arguing.  Just physiology. Then, it's up to you to test to know if it's working or not. If this episode made you flip your workout routine — share it!

Registered dietitian nutritionist Leyla Muedin discusses a New England Journal of Medicine paper (July 2024, cited via Holistic Primary Care) warning about drug-induced magnesium depletion, especially from diuretics, proton pump inhibitors (e.g., Nexium, Prilosec), and certain antibiotics. She notes magnesium is often not routinely measured despite links between deficiency and cardiovascular, metabolic, and neurological problems, including arrhythmias (AFib, long QT, torsades), endothelial dysfunction, and longer ICU stays. Prevalence estimates range from 7–11% (up to 20%) in hospitalized patients and 2–4% among outpatients, with higher rates among long-term PPI and diuretic users. She reviews symptoms and causes, explains limits of serum magnesium testing, highlights associations with diabetes, alcohol use, low potassium and calcium, and outlines evaluation options and oral repletion approaches, favoring better-absorbed forms like magnesium glycinate over oxide due to diarrhea risk.

Send us Fan MailThis week, I'm sharing 7 simple foods that can help make weight loss feel easier—no extremes, no restriction, just small shifts that actually support you. I talk about why some foods work with your body instead of against it, how to stay full longer without overthinking it, and the one simple formula that can change how you approach eating altogether. If you've ever felt tired of starting over, this episode might help you see things a little differently.Quote of the Week:“Each time you eat is an opportunity to nourish—not just your body, but your future.”— Dr. David KatzCitations (Peer-Reviewed Research)Leidy HJ et al. (2015). The role of protein in weight loss and maintenance. American Journal of Clinical Nutrition.Westerterp-Plantenga MS et al. (2009). High protein intake and weight management. British Journal of Nutrition.Rolls BJ et al. (2004). Energy density and satiety. American Journal of Clinical Nutrition.Rebello CJ et al. (2016). Oats and satiety. Nutrition Reviews.Douglas SM et al. (2013). Protein snacks and appetite control. Nutrition Journal.McCrory MA et al. (2010). Dietary fiber and satiety. Journal of Nutrition.Kim SJ et al. (2016). Legumes and satiety. Obesity.Let's go, let's get it done.Get more information at: http://projectweightloss.org

Dr Deb Muth 00:03Well, welcome back to Let’s Talk Wellness Now. I am your host, Dr. Deb. And what is the most talked-about peptides in functional medicine? aren’t actually FDA approved. Not because they don’t work, but because no one’s funded the research to prove it yet. The truth is, some of the compounds that dominate wellness forums, BPC-157, TB-500, thymosin beta-4, epitalin, occupy a fascinating space between breakthrough science and unregulated experimentation. In today’s episode, we’re stepping into that grey zone, the world of investigational peptides, to separate mechanism from marketing. I’m going to walk you through the science that actually shows and where it stops, how to evaluate claims when human data don’t yet exist, and the quality, purity, and safety red flags that you need to recognise. Dr Deb Muth 01:06I created it in a previous episode, so go check that one out. And why honesty is the most important prescription in peptide medicine. If you’ve ever wondered whether these research-only peptides are the frontier of healing or the next functional medicine fad, this episode is for you. So grab your cup of tea or coffee, get comfortable, and let’s talk about what it really means to use peptides that are promising but still under investigation. So we’re going to break just for a second here and have a word from our sponsor. It is because of them that we stay on the air. So thank you for this. And we will be right back. Did you know sweating can literally heal your cells? Infrared saunas don’t just relax you. They detox your body, balance hormones, and boost mitochondrial energy. I’m obsessed with my Health Tech sauna. And right now, you can save $500 with my code at healthtechhealth.com slash dr-muth-req-25. Dr. Deb Muth 02:15All right, guys, welcome back. Let’s dive into investigational peptides, the evidence gap. So the following peptides we’re about ready to discuss are extensively in integrative, functional, and regenerative medicine circles. They may have intriguing mechanisms and promising preclinical data. However, they lack FDA approval, and the evidence quality varies dramatically. from interesting preliminary research to essentially no human data at all. And this distinction is really critical for maintaining scientific integrity. So let’s talk about immune-modulating peptides. There’s thymus and alpha-1, and this is an international story on the thymic peptides. Thymusin alpha-1, known as TA1, is marketed internationally as zidaxin. Dr. Deb Muth 03:16It’s a 28-amino acid polypeptide originally isolated from thymusin fraction 5, which was extracted from bovine thymus tissue. Modern production uses synthetic peptide synthesis. The thymus gland is located behind the sternum and is the primary site for T cell maturation, and thymic peptides like TA1 play roles in human system development and regulation. Now, I love thymus peptides. I love thymus glandular products. I’ve used thymus glandular products for decades. Ground-up animal thymus gland is basically what it is. There are a couple of different supplement companies that I’ve used over the years that are amazing with this. And they do a fantastic job, and they really do help to support the immune system. So when thymus peptides came out, it was really exciting because it took the whole idea of thymus support to a new level. Dr. Deb Muth 04:17The mechanism actually behind the thymus in alpha-1 is complex and involves multiple aspects of immune function. At the cellular level, TA1 enhances T cell maturation and differentiation, particularly the development of helper T cells and cytotoxic T cells. It modulates T cell receptor expression and can influence the balance between Th1 cell-mediated immunity and Th2 humoral immunity responses. And it also enhances the natural killer cell activity and modulates dendritic cell function, which are critical for antigen presentation. and initiation of adaptive immune responses. And on the cytokine level, TA1 influences production of interleukin-2, IL-2, interferon gamma, IFN-γ, and interleukin-10, IL-10. Dr. Deb Muth 05:19These create immune modulatory rather than simple immune stimulatory effects. This is a very important distinction because TA1 appears to help balance the immune system rather than simply ramping this up, which theoretically makes it safer in conditions where immune overstimulation would be a problem, such as an autoimmune disease. Hashimoto’s, autoimmune, lupus, Sjogren’s, any of those autoimmune diseases, we don’t want to overstimulate their immune system. So you want to use a product like this that’s non-stimulating. Now, the regulatory status on TA1 is geographically variable and represents one of the challenges in discussing this peptide with patients. It is not FDA-approved in the United States. However, it is approved in several other countries for specific conditions. Dr. Deb Muth 06:19In Italy, it’s approved for the treatment of chronic hepatitis B and hepatitis C. In China, it’s approved for chronic hepatitis B and adjunct immune compromised patients receiving vaccinations or suffering from certain infections. It has an orphan drug designation in the United States for certain cancer indications, but its designation does not constitute approval. It simply provides regulatory incentives for further development. So the evidence base for thymosin alpha-1 is substantial in some areas but comes primarily from non-US populations and research groups, which creates challenges in evaluating quality and generalizable information. So in hepatitis B and C, multiple clinical trials, many conducted in China and Italy, have examined TA1 as an adjunct to antiviral therapy. Dr. Deb Muth 07:21A meta-analysis by Wu and colleagues published in the Journal of Viral Hepatitis in 2013 examined 23 randomized controlled trials, including over 2,000 patients with chronic hepatitis B. The analysis found that combining TA1 with nucleoside analogs like LAMVDUDE or an and TCAVAR improved the hepatitis antigen seroconversion rates by HBV DNA clearance compared to its nucleoside analogs alone. And the effect sizes were modest but statistically significant, with the HBE-AG seroconversion rates improving from about 24% with antivirals alone to 38% in combined therapy. Now in hepatitis C, early trials before the development of direct-acting antivirals showed that TA1 combined with interferon alpha improved sustained virological responses, and compared to interferon alpha, Dr. Deb Muth 08:30Furon alone, particularly in difficult-to-treat populations like those with a genotype one or a high viral load. However, the advent of highly effective direct acting antivirals that achieve SRV rates, sorry, SVR rates exceeding 95%, the role of TA1 in hepatitis C has become less clear. Now in sepsis and critical illness, more recent interest has focused on TA1 in severe cases of sepsis and septic shock. Ren and colleagues published a systematic review and meta-analysis in the Frontiers of Immunology in 2022, analyzing 18 randomized controlled trials, including 1787 patients with severe sepsis or septic shock the pooled analysis showed that ta1 administration was associated with reduced 28-day mortality relative risk at 0.70 meaning a 30 reduction in mortality compared to the standard care alone and the effect appeared Dr. Deb Muth 09:39most pronounced in patients with sepsis-induced immunosuppression measured by HLA-DR expression in monocytes. Now, this is amazing because going forward, we’re going to talk about something that’s commonly known as cytokine storm. Now, cytokine storm really became apparent since 2020 with the viral infection that we’re dealing with in the world today. But they were already looking at this kind of cytokine storm produced by sepsis or sepsis-induced immunosuppression. And it triggered this hyperinflammatory response called the cytokine storm. And many patients who survived the initial phase of the immune suppressed stata, characterized by a T cell exhaustion, reduced antigen presentation, and increased susceptibility to secondary infections. Thymusin alpha-1, TA1, may help restore this immune competence in this phase. However, it’s important to note that patient selection and timing are critical. Dr. Deb Muth 10:43Giving this immune stimulant during a hyperinflammatory phase could theoretically worsen outcomes. So you don’t want to give it to them while they’re in the flare up or the sepsis or the infection, but given to them during the immunosuppression phase afterwards might be beneficial. Now there is also some cancer immunotherapy that we see with TA1 and has been studied as an adjunct in cancer treatment with the hypothesis that it could enhance immune surveillance and response to tumors. And a comprehensive review of Garci and colleagues published in Expert Opinion on Biological Therapy in 2007 examined multiple trials in melanoma, lung cancer, hepatocellular carcinoma, and other malignancies. And the results were mixed. Some trials showed improvement in the immune parameters, increased CD4 in T-cells. improved lymphocyte proliferation responses and some actually showed trends toward improved progression free survival but overall survival benefits were inconsistent and the heterogeneity of the cancer types treatment protocols and outcome measures makes a definitive conclusion difficult as a vaccine adjunct several studies particularly from china have examined ta1 as an adjunct to enhance vaccine responses Dr. Deb Muth 12:11in immune-compromised populations, including the elderly, dialysis patients, and transplant recipients. The rationale is sound. These populations often mount suboptimal antibody responses to vaccines, and TA1’s immune-enhancing effects might improve protection. There are small trials. They have shown improvement in seroconversion rates of hepatitis B vaccines and influenza vaccine in these populations. And though large-scale confirmatory studies are limited, there is a possibility here. Now, on their safety profile, one of the appealing aspects of thymusin alpha-A TA1 is that it’s apparently favorable safety profile in clinical trials. There are some injection site reactions with a little redness, a mild discomfort, and most commonly reported adverse effects. is that their severe adverse events attributable to TA1 have been rare in published trials. However, comprehensive long-term safety data are limited Dr. Deb Muth 13:13And theoretically, concern exists that immune modulation could potentially trigger or exasperate autoimmune conditions in susceptible individuals. Though this hasn’t been clearly demonstrated in clinical trials, integrative medicine considerations for integrative practitioners concerning the thymus and alpha-1, several factors require careful thought. First, sourcing and quality control are critical concerns. Since it’s not FDA approved, TA1 available in the United States typically will come from a compounding pharmacy or an international supplier with variable quality assurance. And pharmaceutical grade product with certificates of analysis showing purity, sterility, and endotoxin testing is essential, but it is readily available from many of these companies. Second, patient selection matters immensely. TA1 should be considered in complex cases where conventional approaches have been insufficient, such as chronic viral infections not responding adequately Dr. Deb Muth 14:21to standard antivirals, post-viral syndromes with evidence of immune dysfunction, cancer patients with immune suppression in consultation with oncology, and it should generally be avoided in active autoimmune disease unless there’s a compelling rationale and close monitoring. Now, TA1 is not a standalone therapy. In cases of chronic viral infection, Comprehensive immune support includes addressing nutritional deficiencies, optimizing vitamin D levels to be between 50 and 80, adequate zinc, selenium, and vitamin A, optimizing gut health since 80% of our immune function is in the gut, you need to optimize gut function. Managing stress from the HPA access dysfunction, chronic cortisol elevation, suppression, and immunity, ensuring adequate sleep, immune memory consolidations during sleep, addressing any metabolic dysfunction, insulin resistance, repairs in the immune function, and the bottom line on thymus and alpha-1 is Dr. Deb Muth 15:26is that it represents legitimate medicine in other countries with a substantial evidence base in specific contexts, but it remains experimental in the U.S., and practitioners using it should provide comprehensive, informed consent about its regulatory status, evidence quality, and source verification. while ensuring it’s part of comprehensive protocols. It is not a magic bullet. And again, what you’re gonna hear me say quite often here is that many of these peptides should be used in conjunction with something else. They should not be used alone. And can peptides be stacked? The answer is yes, they can. So if somebody has an insulin resistance, or a metabolic dysfunction, they can tier TA1 with a GLP-1 like terzepatide or semiglutide. That is not a problem to do that. You need to just work with a practitioner that understands how to do that effectively. So let’s look at BPC-157. Dr. Deb Muth 16:26This is a phenomenon I love BPC-157. Let’s separate it from marketing to actual mechanism of actions here. So BPC-157 stands for Body Protection Compound 157. It is a chain of 15 amino acids that are described as a partial sequence of body protection compound, a protein found in human gastric juice. It has become one of the most hyped peptides in regenerative medicine inside the athletic performance and biohacking communities with claims ranging from healing tendons and ligaments to repairing gut lining or reversing organ damage. The challenge is separating the legitimate mechanisms of science from the marketing hype. The proposed mechanism of BPC-157 are biologically plausible and intriguing. The research suggests that it may influence several growth factor pathways, including vascular endothelial growth factor, VEGF, which promotes new blood vessel formation and has improved better supply of blood flow to injured tissues, theoretically accelerating healing. Dr. Deb Muth 17:40It may also affect fibrous blast growth factor, FGF, and transforming growth factor beta, TGF beta pathways. both involved in tissue repair and remodeling. And some studies actually suggest that BPC-157 modulates inflammatory cascades, potentially reducing excessive inflammation while promoting the resolution phase that allows tissue rebuilding. Now I want to talk just a few moments here about these different tests that we’re talking about tgf beta veg f for those of you who are in our mold world you are very familiar with these uh lab tests we do this to see if you have a mold exposure what’s happening to your body and it’s been very challenging to try to heal this part of the mold illness and manipulate these VEGFs and TGF betas. And so with the fact that BPC helps us modulate this inflammatory cascade, BPC can be very helpful in the world of mold or mycotoxin illness in repairing those parts of the body that have been damaged by the mycotoxins. Dr. Deb Muth 18:48Now there is animal research on BPC-157. It is extensive and primarily from a research group led by pre-drag, oh, I can never say these names, Cyrek at the University of Zagreb in Croatia. Published studies in animal models have shown accelerated healing in a remarkable variety of injury types. A 2011 paper by Chang and colleagues in the Journal of Applied Physiology demonstrated that BPC-157 improved therapy tendon healing in rats with Achilles tendon injuries, and the treated rats showed increased tendon outgrowth, better cell survival in the injured area, enhanced cell migration to the injury site, and improved biochemical strength of the healed tendon compared to controls. Multiple other animal studies have shown similar promising effects. Ligament tears, healing faster in rabbits, muscle damage recovering more quickly in rodent models, gastric ulcers healing in rats given experimental induced ulcerations, inflammatory bowel lesions improving in mouse models of colitis, and even bone to tendon healing showing enhancement in animal studies. Dr. Deb Muth 20:02The breadth of injury types showing benefit in preclinical models explains the enthusiasm of this peptide. However, this is critical. These animal studies, primarily in rodents and rabbits, animal models of injury healing don’t reliably translate to human clinical outcomes. And the doses used in these animal studies when converted to human equivalent doses vary widely. And optimal human dosing is completely unknown at this point. it is all considered experimental and perhaps most importantly there are essentially no peer-reviewed controlled clinical trials in human published in humans published in major medical journals in a 2001 review of arthroscopy and the journal of arthroscopic and related surgery specifically examined in the evidence of bpc 157 and other peptides in musculoskeletal medicine The authors concluded bluntly that BPC-157 lacks evidence from randomized controlled trials and has an unknown safety profile in humans. Dr. Deb Muth 21:09 They emphasized that the jump from animal data to recommending peptides for humans use bypasses the fundamental requirement for Phase I safety studies, Phase II dose-finding studies, and Phase III efficacy trials that would establish whether BPC-157 actually works in humans and whether or not it’s safe. The absence of human safety data is particularly concerning given BPC-157’s proposed mechanisms. Peptides that influence growth factor signaling and angiogenesis could theoretically have off-target effects. Uncontrolled angiogenesis, for instance, is a hallmark of cancer progression. Tumors require blood vessel formation to grow beyond a certain size. And while there’s no evidence that BPC 157 promotes cancer, The complete absence of long term human safety studies means we simply don’t know. This isn’t fear mongering. It’s acknowledging uncertainty and uncertainty exists and understanding that if you’re choosing to use peptides like BPC 157, you are doing it in an experimental model. Dr. Deb Muth 22:17We’re experimenting with the doses that are being used. And there is potential for it to cause cancer cells in your body to grow. And you need to be aware of this and understand the risks that you’re taking when you’re using an investigational or off label use peptide. Now, quality control issues with BPC also exist. It’s not FDA approved for any indication in the US. It’s not approved in any major regulatory jurisdiction worldwide. It’s marketed as a research chemical explicitly to bypass FDA oversight. And commercial sources selling BPC-157 range from compounding pharmacies, which have some quality standards but are not FDA inspected. You can take that for what you want to believe on that one. to overseas suppliers operating with absolutely no quality assurance whatsoever. If you are choosing to use BPC-157, you have to understand who’s manufacturing it for you, where you are getting it from, how pure it is. Dr. Deb Muth 23:26You want to make sure that you have the certificate of analysis and that it does not contain bacterial endotoxins that can contaminate the peptide or degrade the peptide and cause other issues for you. So when you talk about peptides with patients regarding BPC-157 or if you’re listening to this and you’re already using BPC-157 or other peptides, that are quote-unquote not for human consumption, an evidence-based response acknowledges both the appeal and the limitations. And you want to talk about the animal data that’s definitely showing some progress and some potential, but we don’t know what we don’t know in humans. If people are willing to take that risk, that is up to them to do that. But using BPC right now is experimental and people need to be aware of that. Are there evidence-based alternatives for patients with tendon or ligament injuries? Dr. Deb Muth 24:26And there are. There’s PRP, which has been studied in multiple randomized controlled trials. for conditions like lateral epicondylitis, tennis elbow, Achilles issues, patellar issues, knee issues. However, I want to caution you on this too. So the study that was done by Cox and colleagues in muscles, ligaments, and tendons in the Journal of 2014 showed modest benefits in pain and function compared to controls. And though the effects vary by injury type, PRP preparations can be helpful. You have to understand that a lot of times when people are doing PRP injections in their office, they are not doing it exactly the same way it was done in the study. And not to mention, if you’re using your own PRP to heal a ligament or a tendon or help your arthritis and you’re 60 or 70 years old, That is not good quality protein rich plasma. It is old protein rich plasma. And you’re not going to see necessarily the same benefits that you would see if you were using placental tissue or umbilical tissue. Dr. Deb Muth 25:33You also want to address the nutritional deficiencies or support that’s needed for connective tissue healing. And these are collagen peptides dosed at 15 grams a day. And this has been shown in a study by Shaw and colleagues in the American Journal of Clinical Nutrition in 2017 to augment collagen synthesis when combined with intermittent loading. Vitamin C is also an essential cofactor for collagen production and stabilization of collagen structure at a dose of around 500 to 1000 milligrams a day to support this process. You also need to have good adequate intake of copper and zinc. These are cofactors in collagen. Silica is also important. This comes from horsetail extract. This provides additional support as well. So more importantly, I think remembering that rehabilitation matters as well. Doing these protocols without doing some rehab is not going to get you where you want to go. Dr. Deb Muth 26:33There’s a research study by Alfredson and others for Achilles tendinopathy using the control lengthening of muscle tendon units under load to promote tendon remodeling and healing. These protocols have solid evidence and cost nothing beyond professional guidance from a physical therapist. They are important for patients seeking cutting edge regenerative approaches. Stem cell therapies, growth factors, concentrates derived from patients’ own tissues like PRP. These have a lot of good endogenous materials and they have good safety profiles. BPC-157 represents the perfect example of how promising Preclinical science gets marketed far beyond the evidence and it may eventually prove to be valuable. I think it will. But right now that determination does require some human studies and hopefully with the administration that we have right now and Bobby Kennedy, we will actually start to see some of that occur. Now the next peptide I want to talk about is TB4, thymus and beta-4. Dr. Deb Muth 27:36This is a wound healing peptide. It is a 43 amino acid peptide that’s naturally present in virtually all human cells except red blood cells. It’s actually one of the most abundant peptides in the human body, particularly concentrated in blood platelets, wound fluid, and many tissues. It’s naturally ubiquity makes it mechanistically interesting. The body wouldn’t produce it in such abundance if it didn’t serve a function. So the primary role of TB4 involves building G-actin. It’s a form of monomeric actin. And it’s structural protein that forms the microfilaments within the cells, providing cellular structure and enabling cell movement. TB4 prevents from F-actin filaments. I’m not going to talk too much about this. It’s really critical for wound healing as cells need to migrate into the injury sites. Dr. Deb Muth 28:37so the cell shape changes and the cellular response to the injury. So think of this as though you tore your meniscus and the body created all this TB4 to come to that injury to try to heal that site. That’s exactly what the TB4 is doing inside the body when there’s an injury. It’s been shown in research to help produce new blood vessel formation, promote endothelial cells, It helps modulate inflammatory cytokines, potentially reducing TNF-alpha, IL-1, and possibly protecting in programmed cell death, which we call apoptosis. And some studies suggest that it is cardioprotective in its effects in animal models of myocardial infarction, so heart attack, and neuroprotective in other models for brain injury. Now, these remain to be preliminary, but they are being seen. So the regulatory status on TB4 can create some confusion. Dr. Deb Muth 29:40The natural TB4 molecule itself is not FDA approved as a drug. However, TB4 based drug candidates called RGN259, formerly TB4, has been in the development by regen tree for corneal injuries of the dry eye disease. And as of recent updates, this drug is completed phase three trials for its neurotrophic keratopathy, severe corneal condition. But the FDA approval is still pending. So that means that the most advanced TB4-based pharmaceuticals hasn’t yet crossed the finish line for approval. The commercial peptide market further muddies the picture with TB500, which is often described as the synthetic fragment of TB4. However, this extract’s relationship between TB500 and TB4 varies depending on the source. Dr. Deb Muth 30:41So some claim that TB500 is identical to TB4, but positions 1 through 4 suggest it’s a different fragment. and the quality control across suppliers is not existent. So this confusion is part of why recommending TB500 becomes problematic for practitioners and patients, often because they aren’t certain what molecule they’re actually getting. The evidence base for TB4 in humans is limited, primarily to eye research, and the studies from Sohn’s and colleagues published in journals like Vitamins and Hormones in 2016 have examined topical TB4 for corneal injuries and neurotrophic keratopathy, dry eye, and other surface diseases. Now, these studies showed some promise in promoting this, and there is, however, a topical application to the cornea that is vastly different from a systemic injection. So for systemic use in wound healing, musculoskeletal issues, Dr. Deb Muth 31:42cardiac protection, neuroprotection, human clinical trials. There is scarce to non-existent evidence in humans. Most of the evidence remains in animal models or cell culture studies. And a review by Flip and colleagues in the Journal of Investigational Dermatology in 2006 detailed TB4’s effects on the matrix remodeling during wound repair in animal models, showing effects on collagen disposition, granulation, tissue reformation, and wound contraction. Another review by Ho and colleagues in expert opinion on biological therapy in 2007 discussed TB4’s potential in tissue regeneration and regenerative medicine, but noted the field remained largely blank. preclinical. So this is really important again to understand that there is just not enough human data. So there is a concern with cell division and migration. This theoretically exists Dr. Deb Muth 32:45for the potential effects on cancer cells, which would also rely on migration and division and other intended consequences of disrupting normal cellular architecture. These aren’t proven risks, but they are unexplored questions that we need to be aware of when we’re using peptides. This can cause cancerous tissue to grow. Very similar to what we talked about with BPC-157. These are also sold as research chemicals. There is no FDA oversight. So purity, potency, contaminations all still exist for these peptides. Now from an integrative perspective, the natural presence of TB4 in wound fluid and its biological roles in healing are legitimate science. in presence does not equal therapeutic utility. The body tightly regulates where and when and how much TB4 is present through natural production and bypassing that regulation with external dosing may or may not cause us to have beneficial or introduce risk. Dr. Deb Muth 33:49So we need to know that this is experimental use. Those people who are seeking wound healing and tissue repair the evidence-based approach of the body’s own capacity to heal is huge definitely want to be increasing your protein intake optimizing your zinc copper vitamin c and vitamin a and then managing glucose is really important during this time as well so let’s talk about a fun topic now and that’s growth hormone secretagogues this is the anti-aging hype machine these peptides in this category are things like semoralin ipameralin cjc 1220 1295 and others and among the most aggressively marketed in anti-aging and longevity medicine they all share a common goal stimulating the pituitary gland to release more growth hormone and the appeal is understandable. GH levels decline with age, and this decline is associated with increased fat mass, decreased lean muscle, reduced bone density, and other aspects of aging. Dr. Deb Muth 34:55The other times we’ll see growth hormone levels decline significantly is with chronic illness, and the logic is to restore youthful GH levels and youthful physiology. Now, semirelin from an FDA approved diagnostic to compound anti-aging product. Semirelin is a 29 amino acid peptide representing the first 29 amino acids of the full 44 amino acid human growth releasing hormone, GHRH. We talked about this on another episode of the podcast. And you can go back and listen to that one a little bit if you want. This fragment contains the complete biological activity of the full GHRH molecule and it binds to GHRH receptors in the anterior pituitary and stimulates growth releasing peptides, growth hormone releasing peptides. Semirelin was previously FDA approved as diagnostic testing of growth hormone secretion, essentially, to determine if the pituitary could still respond to GHRH stimulation in patients being evaluated for growth hormone deficiency. Dr. Deb Muth 36:06However, the manufacturer was discontinued and there was no longer an FDA approved semirelin product on the market in the United States. What exists now is semirelin available from compounding pharmacies used off label for anti-aging, body composition, and general growth hormone optimization purposes. This represents a significant gray area. Again, compounding medications serve a very important role, but they need to meet certain recommendations and regulations, as we’ve talked about in the past. You want to make sure that your compounding pharmacy that you’re obtaining semirelin from is qualified to do that, that they are doing best practices, and that you’re getting a good product. The theoretical advantage to semirelin over direct growth hormone administration is that it preserves more of the physiological growth hormone secretion patterns. Natural GH is released in pulses, primarily during sleep, not as a continuous elevation. Dr. Deb Muth 37:07So semirelin stimulates the pulses rather than providing a constant super physiological growth hormone level. And that pulsatile pattern is thought to reduce some of the side effects and metabolic concerns that we have with continuous growth hormone exposure. However, the evidence supporting semirelin for anti-aging and body composition in healthy adults is minimal. Most of the data comes from studies conducted in the 1990s when the FDA approved product existed. Not that that means it’s bad. We have drugs that have been in the market for over a hundred years that are still there, that still have the research and are still being used successfully and safely today. So we don’t want to let that really make us think that this product isn’t safe. So a 2006 review from Walker in Clinical Interventions of Aging suggested that semirelin might be a better approach than direct GH for adult onset growth hormone insufficiency, but they do acknowledge that the evidence was limited. Dr. Deb Muth 38:12And although we don’t have any large scale trials that we can examine for semirelin’s efficacy, it is now commonly prescribed. And the optimal dosing for anti-aging purposes is still unknown. It is considered experimental and it does vary from person to person, but it is still unstudied. The effects on cancer risk, cardiovascular disease, metabolic dysfunction over long time periods are also still unknown. I would argue that the side effects or the risk factors of not having growth hormone are equally as bad as the unknowns that we have here. We’re not looking to try to get super physiological doses. We’re trying to restore youthful GH levels. Typically, we’re not trying to restore back to a 20-year-old. We’re trying to restore back maybe 10 years. That is a better way of doing this. And I think that’s important for people to understand. Now, ipamirelin is the ghrelin mimicker. Dr. Deb Muth 39:12Ipamirelin is a pent-up peptide, five amino acid, that acts as a growth hormone secretagogue receptor, a GHS-R agonist. It mimics the action of ghrelin, the hunger hormone, that also stimulates growth hormone release. The proposed advantage over earlier secretagogues is that ipamirelin stimulates growth hormone release without significantly affecting cortisol, prolactin, or other glucose things, which can be increased by growth hormone secretagogues. The regulatory status is clear. Ipamirelin is not FDA approved for any indication. It’s sold as a research chemical. Human evidence is thin. It’s limited to single dose studies examining how quickly it’s absorbed and metabolized with minimal data on dosing and clinical outcomes. Now there are marketing claims for ipamirelin and they are extensive. Dr. Deb Muth 40:13It increases lean muscle mass, it decreases body fat, it improves sleep quality, faster recovery from workouts, enhanced injury healing, better skin quality. The evidence supporting these claims in humans is not available we don’t have it these are claims that are made by the effects that we know from growth hormone so it’s not necessarily a bad thing we know what growth hormone does we know growth hormone does all of these things if ipamorelin is a precursor to that it will obviously help improve those things making that correlation of what growth hormone does So there are safety concerns that mirror the same as any other growth hormone elevating therapy. It can cause fluid retention, joint pain, carpal tunnel syndrome, insulin resistance, glucose intolerance, and theoretically, can it increase calcium? cancer risks? It can because IGF-1 promotes cell proliferation and can inhibit apoptosis in cancer cells. Now remember, your body makes IGF-1. Dr. Deb Muth 41:15If it’s not making enough of it, that’s a problem. If it’s making too much of it, That’s a problem. So just understand that if you are adding these things, and especially in elevated doses, you are taking a potential risk. So there is also now CJC 1295 is a modified GHRH analog of 30 amino acid peptide based on GHRH structure, but with modifications. So it includes the addition of drug affinity complex, DACC, DAC, which involves conjugation with a small albumin binding molecule, dramatically extends the peptide’s half-life from minutes to as much as potentially a week or more. And this creates sustained growth hormone elevation rather than that pulsatile release. There are actually two versions of this. There’s CJC 1295 with DAC, longer acting version, and CJC 1295 without DAC, which is essentially a shorter duration of semirelin. Dr. Deb Muth 42:19And so when we’re comparing products, it is… only the difference between long acting and short acting. The human evidence for CJC 1295 is limited to a single published phase one study by Techman and colleagues in the Journal of Clinical Nutrition and Metabolism in 2006. And the study involves 18 healthy young adults showed that CJC 1295 with DAC produced a sustained elevation of GH and IGF-1 lasting several days after the injection. That’s essentially the entire published human evidence of this peptide. There are no phase two studies examining optimal dose. So that is all considered experimental. And there is no phase three studies examining clinical efficacy. So the sustained GH levels created by CJC 1295 with DAC raises specific concerns because the natural GH secretion It goes up and down, up and down, up and down. Dr. Deb Muth 43:19And that constant elevation may have a different metabolic and cellular effect. And we just really don’t know what that’s going to be yet. So we can understand that elevated IGF-1 levels can theoretically increase cancer concerns and metabolic risks. So rather than always injecting peptides, which are very expensive… You can do other things. And there was a study by Hartman and colleagues in the Journal of Clinical Endocrinology and Metabolism in 1992 that demonstrated the 48-hour fast increased integrated growth hormone secretion five-fold through increased GH levels. Now, the problem with this is fasting for 48 hours is a challenge. And how long is it going to increase the growth hormone secretion without causing issues? Or in general, how long is it going to go up? Dr. Deb Muth 44:19So we have to be cautious about that as well. Sleep optimization is non-negotiable. The majority of growth hormone secretion occurs during sleep, slow wave sleep, typically the first sleep cycle, and poor sleep quality or insufficient sleep typically. can dramatically affect your growth hormone levels. And then high intensity interval training, HIIT resistance training can stimulate growth hormone as well. This was seen in a study by Godfrey and colleagues in sports medicine in 2003 and was examined in exercise-induced growth hormone responses to athletes. So we definitely see these kinds of things. So let’s talk about some longevity peptides now. These expand the telomere. So there’s epitalin and epithalamin and when these are used in anti-aging they can produce some amazing results. Dr. Deb Muth 45:22So epitalin is a synthetic terapeptide, just four amino acids. It was originally synthesized as a simplified version of epithalamine. a pineal gland extract containing multiple peptides. The synthetic four amino acid version was created to isolate what researchers believed might be the active anti-aging component. The mechanism produced for epitalin centers on telomere and telomerase, Telomeres are protective caps at the end of the chromosomes consisting of repetitive DNA sequencing. And every time a cell divides, telomeres shorten slightly because DNA polymers cannot fully replicate the ends of the linear chromosomes. So this progressive shortening acts as a molecular clock. After 50 or 70 divisions, the telomeres become critically short, triggering a cellular senescence. Dr. Deb Muth 46:22This telomere shortening is one mechanism of cellular aging and telomeres in the enzyme that can rebuild telomeres by adding these caps back onto the end of the chromosome. It’s active in stem cells, germ cells, and unfortunately in about 85 to 90% of the cancer cells. In most adult somatic cells, telomerase is inactive or present at very low levels, allowing the telomeres to shorten with division. The research on epitalin suggests it might activate this telomeres act telomeres process primarily from a research group led by Vladimir in Russia. Vladimir Kavasan in Russia. He is a huge peptide researcher or was he passed away with publications dating back to the early 2000s and a study published in bio gerontology in 2000 by Kavasan Dr. Deb Muth 47:25and colleagues examined the effect of epitalin on the lifespan of fruit flies, and they treated fruit flies that showed a modest increase in mean and maximum lifespan compared to its controls by approximately 10 to 15% lifespan extension in some experimental groups. And there were other studies in 2003 that examined epitalamine in a female Swiss-derived mouse. This was done by Ann Simove and colleagues. And the researchers reported that epitalin treatment was associated with increased lifespan as well. And the most cited mechanistic work comes from cell culture studies. And that is also Cavason’s group that published this research in 2003, showing increased telomeres activity in cultured somatic cells again. More recently, between 20 and 25, the series of publications have continued to explore epithelial effects on telomere dynamics in cell cultures. Dr. Deb Muth 48:32So there is a lot of research that’s been done. The mass majority has been done on epithelin. And most of it has been done by a single research group in Russia. There is some restrictions on some of the cell culture data that we’re seeing. And it does show that epithelin sometimes can be described as a regulating hormone. Carcadian rhythm for melatonin production, which is derived by the penile extracts. And however the evidence for this affects minimally and mechanistically unclear, the pineal gland primarily functions as melatonin secretion in that light-dark cycles. So Epithalin or epitalin is not FDA approved. It is not approved for any major regulatory jurisdiction. It is sold as a research chemical only. Dr. Deb Muth 49:33So you need to follow the same safety profiles that we’ve talked about in other episodes and in today’s episodes. And when we’re talking about epithalin, and we’re excited about it being an anti-aging science, we should balance this with the honesty and the evidence of the quality of that evidence. We don’t know its safety effect. We don’t know if it’s going to increase the risk of cancer. We can’t verify that. And we need to be using it in an experimental use of unknown risks only. Of course, diet, physical activity, stress management, sleep quality, all of those things are important for us to be looking at when we’re looking at these peptides. Now, I want to get into some of the brain peptides. This is the nootrophic frontier. C-Max and C-Lank, there is Russian pharmacology that’s done. C-Max and C-Lank represent an interesting case study in how different regulatory environments and research traditions Dr. Deb Muth 50:36create challenges in evaluating this evidence. Both peptides were developed in Russia, are approved for their specific indications and have substantial Russian language and literature supporting their use. However, the FDA approval in the United States is still not there. C-Max is a seven amino acid. It’s a synthetic analog. It is a fragment, particularly ACTH 4 through 10. It’s sometimes called the melanocortin effects because it involves the melanocortin receptors of the central nervous system. CMAX was developed by the Institute of Molecular Genetics of Russia Academy of Sciences and is approved in Russia for several indications, including acute stroke, transient ischemic attacks, cognitive disorders. It has Russian approval and is based on clinical trials primarily in Russia. Dr. Deb Muth 51:39It does help to increase brain-derived neurotrophic factor, BDNF, a protein critical for neuroplasticity, the brain’s ability to form new connections and adapt to the challenges. BDNF supports neuronal survival and promotes growth of these new neurons. C-Max also influences neurotransmitter systems, particularly dopamine and serotonin, and there is some research that suggests it affects on metabolism as well, and endogenous opioid peptides that involve pain reception and mood regulation. So it has some good potentials there. There is also C-Link, which is a hepatopeptide structurally similar to Tufts’ and an immune modulatory peptide. It was also developed in Russia and was approved for anxiety disorders as a neurotropic. Its effects involve anxiolytic effects, possibly through the GABAnergic system or the GABA system of the brain, and immune modulation. Dr. Deb Muth 52:44The Russian research is examined by C-Link for anxiety disorders. and finding reductions in anxiety without sedation. There is a dependency potential or cognitive impairment does not exist like it does with benzodiazepines with C-Link. So that is really good. And they do report attention and memory improvement using C-Link. There is a study that was done in neuroscience and behavioral psychology in 2018 that examined C-Linx effects and proposed that it exerts cytoprotective effects through BDNF pathways similar to C-Max. So both of these are Russian research-based They’re not wrong or fraudulent. It’s just that they are from Russia and we all have our concerns with Russia. However, that does not necessarily mean their research doesn’t hold quality. Dr. Deb Muth 53:49Neither peptide is approved by the FDA, and so you are using this off-label. The same rules apply for all of the other peptides that we’ve talked about that are produced off label. You want to do the same things that you would do with anything else. Good protein, omegas, B vitamins, acetylcarnitine, exercise, sleep, all of that still applies when we’re using these peptides. So I want to talk briefly about clinical decision and framework when we’re looking at this. First and foremost, we always want to go to FDA-approved peptides. Secondly, we would look at international approval with peptides that are established in other countries but lack FDA approval. And then preclinical evidence only or experimental peptides. These can be used, but they are not ethically recommended in the traditional medicine world. Dr. Deb Muth 54:50 If patients use them, we need to have appropriate counseling about the evidence surrounding them, the safety, and where to find them. how to find them and how to ask for these certificates of analysis. So I think it’s really good that we were exploring all these peptides and understanding what they are. There’s a lot of controversy out there. There’s a lot of concern out there. And what we can say with confidence is that peptides are powerful biological signaling molecules. Some peptide based medications, semi-glutide, triseptide, PT 141, Lupron that are all FDA approved. can dramatically improve outcomes in patients that are obviously selected for the correct ones. There are many other peptides that we address that are integrative and longevity space in the regenerative medicine. These peptides are all experimental. That does not automatically make them wrong. Dr. Deb Muth 55:50It just means that we need to be honest about what we’re doing with them and we need to be cautious with the patients so that they can make a decision to be part of an experimental study. in looking at how to use these peptides. So peptides are tools like any other tools. They work best in the hands of skilled people, and they are applied to appropriate situations, integrating into comprehensive approaches that address root causes. The most powerful peptide administered to a patient with untreated inflammation, hormonal chaos, nutritional deficiencies, and disorders of sleep will disappoint. The simplest evidence-based interventions apply. to a patient whose foundational physiology has been optimized. And this is the art of the science of peptide, right? If done right, respecting both the power of these molecules and the complexity of human beings that we are privileged to serve can make a difference in their lives. So thank you for listening to this episode. Dr. Deb Muth 56:52I hope this was helpful. If you can know of somebody that might benefit from this, please like, share, and subscribe. It means a lot to us. And I hope you join us for our next episode of Let’s Talk Wellness Now. Welcome to Let’s Talk Wellness Now, where we bring expert insights directly to you. Please note that the views and information shared by our guests are their own and do not necessarily reflect those of Let’s Talk Wellness Now, its management, or our partners. Each affiliate, sponsor, and partner is an independent entity with its own perspectives. Today’s content is provided for informational and educational purposes only and should not be considered specific advice, whether financial, medical, or legal. While we strive to present accurate and useful information, we cannot guarantee its completeness or relevance to your unique circumstances. We encourage you to consult with a qualified professional to address your individual needs. Dr. Deb Muth 57:54Your use of information from this broadcast is entirely at your own risk. By continuing to listen, you agree to indemnify and hold Let’s Talk Wellness Now and its associates harmless from any claims or damages arising from the use of this content. We may update this disclaimer at any time and changes will take effect immediately upon posting or broadcast. Thank you for tuning in. We hope you find this episode both insightful and thought-provoking. Listener discretion is advised.The post Episode 258 – Investigational Peptides: What's Promising, What's Hype & What You Must Know first appeared on Let's Talk Wellness Now.

In today's episode, Haylie Pomroy speaks with Dr. Angela Taylor, Doctor of Clinical Nutrition, to discuss how laboratory testing is conducted and applied within a personalized medicine framework. They explore why obtaining a micronutrient panel that evaluates intracellular levels is essential, what components should be included in a comprehensive thyroid panel, and which markers warrant careful evaluation when a patient presents with elevated antibodies. Dr. Taylor also recommends laboratory options for patient testing, explains how free, reverse, and synthetic T3 and T4 influence physiological function, and discusses how iron, ferritin, and vitamin D interact to support overall health and metabolic balance. Learn from the experts themselves here on Fast Metabolism Matters - Functional Lab Markers That Actually Matter.   Dr. Angela Taylor is a Doctor of Clinical Nutrition based in Baltimore, MD. She's double board-certified in both clinical nutrition and functional medicine with a private practice (BrainFood Nutrition) and also serves as Adjunct Faculty at Johns Hopkins University and Nova Southeastern University, teaching Clinical Nutrition. Her specialty areas include Gluten-Free, Autism, ADHD, Sports Nutrition, and Herbal Medicine.   Website: https://www.angelataylor.com/  Facebook: https://www.facebook.com/AngelaTaylor8/   LinkedIn: https://www.linkedin.com/in/dr-angela-taylor-dcn-cns-ldn-ifmcp-0776b122/ YouTube (The Singing NutriDoc): https://www.youtube.com/@SingingNutriDoc  YouTube (Brainfood Nutrition Autism ADHD): https://www.youtube.com/@BrainfoodNutrition    Haylie Pomroy, Founder and CEO of The Haylie Pomroy Group, is a leading health strategist specializing in metabolism, weight loss, and integrative wellness. With over 25 years of experience, she has worked with top medical institutions and high-profile clients, developing targeted programs and supplements rooted in the "Food is Medicine" philosophy. Inspired by her own autoimmune journey, she combines expertise in nutrition, biochemistry, and patient advocacy to help others reclaim their health. She is a New York Times bestselling author of The Fast Metabolism Diet.   Learn more about Haylie Pomroy's approach to wellness through her website: https://hayliepomroy.com   Instagram: https://www.instagram.com/hayliepomroy  Facebook: https://www.facebook.com/hayliepomroy  YouTube: https://www.youtube.com/@hayliepomroy/videos  LinkedIn: https://www.linkedin.com/in/hayliepomroy/  X: https://x.com/hayliepomroy 

This week's Active Life podcast guest is Kristen Blake, functional nutritionist and founder of Kristen Blake Wellness, a virtual root-cause practice serving clients nationwide. With a Master's Degree in Clinical Nutrition and Human Performance and coaching certifications through the AutoImmune Protocol and the Institute for Integrative Nutrition, Kristen specializes in helping men and women optimize energy, metabolic health, cardiovascular risk, hormone balance, gut health, and performance at every stage of life.Kristen's passion for functional medicine began years ago as the wife of a retired NBA player, when she saw firsthand how critical recovery, nutrition, inflammation management, and long-term health strategy are for both athletic performance and longevity. Kristen takes a proactive, investigative approach, using advanced labs, strategic supplementation, and personalized nutrition plans to uncover hidden drivers of health. Her mission is simple: help people stop guessing, start understanding their bodies, and feel their strongest, sharpest, and most resilient, well into their senior years and beyond.To learn more about Kristen and even contact her, visit: https://www.kristenblakewellness.comSend a text

Beyond Probiotics: Rebuilding the Gut Microbiome as an Ecosystem with Dr. Oscar Coatzee and Danielle Arnold  and host Dr. Ben Weitz.   [If you enjoy this podcast, please give us a rating and review on Apple Podcasts, so more people will find The Rational Wellness Podcast. Also check out the video version on my WeitzChiro YouTube page.]   Podcast Highlights Rethinking Probiotics: Keystone Anaerobes, Butyrate, and Microbiome Ecosystems with Designs for Health Dr. Ben Weitz introduces the Rational Wellness Podcast episode challenging the assumption that gut issues are solved by adding more traditional probiotics, arguing microbiome repair is an ecosystem and function problem. He interviews Dr. Oscar Cozo and Danielle Arnold of Designs for Health about differences between transient aerobic probiotics (e.g., lactobacillus/bifidobacteria) and keystone anaerobic strains that form the microbiome's foundation, can engraft, drive down gut oxygen, and support cross-feeding. They discuss live, refrigerated delivery for anaerobes; a spore-capable keystone strain (Anaerostipes); and a case study showing improved food allergies, normalization of Akkermansia, increased butyrate-related effects, and reduction of opportunists without antimicrobials. They cover butyrate's roles (tight junctions, mucus, immune regulation, HDAC inhibition), fiber and resistant starch strategies, stool testing (GI-MAP additions for anaerobes and short-chain fatty acids), diet restriction concerns, and practitioner support and case report publishing with Designs for Health. 00:00 Show Intro and Mission 01:00 Probiotics vs Ecosystem Thinking 02:56 Aerobes vs Anaerobes Explained 07:06 Keystone Species and Engraftment 09:18 New Anaerobic Strains and Allergy Research 11:06 Live Shipping and Feeding the Strains 14:03 Case Study Crowding Out Dysbiosis 18:03 Rethinking the Five R Protocol 24:26 Testing and Prebiotic Pairings 26:52 Butyrate and Microbiome Benefits 28:40 Conventional Probiotics Still Matter 35:04 Sponsor Break Apollo Wearable 36:37 Crowding Out Pathogens and Fungi Role 39:58 Archaea and Mucosa 41:21 Mucus Layer and Biofilms 43:11 Feeding Keystone Microbes 44:18 Fiber Targets and Tolerance 46:51 Probiotic as SIBO Option 48:54 Resistant Starch Basics 51:52 Stool Test Dysbiosis Patterns 54:32 Akkermansia and Metabolism 56:44 Histamine Bugs and Enzymes 01:02:26 Gut Healing Nutrients 01:05:34 Diet Diversity and Reintros 01:08:21 Wrap Up and Product Details 01:13:10 Podcast Outro and Clinic Info   Dr. Oscar Coatzee has over 25 years experience in psychology and nutrition and is currently the VP of clinical education and practitioner support at Designs For Health. He has a bachelor's degree in psychology and a PhD in Holistic Nutrition and  Doctorate of Clinical Nutrition. Danielle Arnold is a clinical nutritionist and Functional Medicine practitioner and she serves as a clinical support specialist at Designs for Health, training healthcare providers in test interpretation and patient care. Dr. Ben Weitz is available for Functional Nutrition consultations specializing in Functional Gastrointestinal Disorders like IBS/SIBO and Reflux and also Cardiometabolic Risk Factors like elevated lipids, high blood sugar, and high blood pressure.  Dr. Weitz has also successfully helped many patients with managing their weight and improving their athletic performance, as well as sports chiropractic work by calling his Santa Monica office 310-395-3111.

Ever feel like staying healthy today requires constant effort, planning, and discipline?You're not imagining it. Modern life is designed in ways that make health harder than it used to be. From ultra-processed foods and sedentary jobs to a culture built around convenience and constant access to calories, our environment often works against our biology.In this episode, we break down why maintaining your health today can feel like an uphill battle—and why that doesn't mean you're failing. It means you're navigating what public health researchers call an “obesogenic environment”: surroundings that make overconsumption easy and physical activity harder.You'll learn how changes in our food system, movement patterns, and daily routines have reshaped the health landscape—and most importantly, what you can do about it.In this episode:Why modern environments promote overeatingHow ultra-processed foods increase calorie intakeWhy sedentary lifestyles changed daily energy expenditureThe hidden role of convenience and “friction” in eating behaviorWhy health requires more intention todayFive practical strategies to make healthy choices easierThe goal isn't perfection—it's awareness and creating an environment that supports your health instead of working against it.You're not failing. You're navigating a system that wasn't built for human health. ReferencesBaumeister, R. F., et al. (1998). Ego depletion. Journal of Personality and Social Psychology. Ducrot, P., et al. (2017). Meal planning, diet quality and body weight. Int. Journal of Behavioral Nutrition and Physical Activity. Hall, K. D., et al. (2019). Ultra-processed diets increase calorie intake and weight gain. Cell Metabolism. Juul, F., et al. (2022). Ultra-processed food consumption and obesity in the U.S. American Journal of Clinical Nutrition. Levine, J. A. (2002). Non-exercise activity thermogenesis (NEAT). Proceedings of the Nutrition Society. Martínez Steele, E., et al. (2016). Ultra-processed foods and added sugars in the U.S. diet. BMJ Open. Matthews, C. E., et al. (2008). Sedentary behavior and health outcomes. American Journal of Epidemiology. Pontzer, H. (2015). Constrained energy expenditure model. Current Biology. Pontzer, H. (2021). Burn: New Research Blows the Lid Off How We Really Burn Calories. Swinburn, B., et al. (1999). Obesogenic environments. Preventive Medicine. Young, L. R., & Nestle, M. (2002). Expanding portion sizes. American Journal of Public Health.Support the showGet Weekly Health Tips: thrivehealthcoachllc.com Join the Thrive Collective Facebook group Let's Connect:@‌ashleythrivehealthcoach or via email: ashley@thrivehealthcoachingllc.com Podcast Produced by Virtually You!

Have scoliosis or know someone who does? In this episode, Dr. Mark Morningstar discusses scoliosis as a complex whole-body condition influenced by genetics, neurobiology, bone health, and lifestyle. He explains why active stability, movement, nutrition, and nervous system regulation are crucial, shares practical prevention tips, and highlights modern, multimodal approaches to help children and adults manage and reduce progression.   Timestamps: (0:04) Welcome to Mind Movement Health Podcast (2:16) Scoliosis Insights with Dr. Mark Morningstar (2:42) Daily Health Changes (2:52) Understanding Scoliosis and Chiropractic Care (8:01) The Role of Nutrition in Scoliosis (13:50) Managing Scoliosis in Different Life Stages (20:45) The Genetic Factors of Scoliosis (27:26) Promoting Movement for Spinal Health (33:10) Misconceptions About Back Pain (36:55) The Brain's Role in Spinal Curvature (47:29) Future Directions in Scoliosis Treatment (49:53) Taking Action for Scoliosis Care (52:21) Connecting with Dr. Morningstar   More about Dr. Mark Morningstar: Dr. Mark Morningstar is a world-renowned chiropractic physician, clinical researcher, and the founder of Back Genius. With over 20 years of experience and more than 60 peer-reviewed publications, Dr. Morningstar has dedicated his career to proving that scoliosis is far more than just a "curve in the spine"—it is a complex, whole-body condition rooted in genetics, neurobiology, and metabolic health. His groundbreaking research was the first to link scoliosis progression to neurotransmitter imbalances, leading to innovative nutritional protocols that help "re-train" the brain to hold the spine in a straighter position. Dr. Morningstar holds diplomate status in Spine Medicine, Integrative Medicine, and Clinical Nutrition. He is the developer of the Scoliosis Activity Suit, a core training suit specifically engineered to create dynamic corrective forces during daily movement to improve scoliosis curvatures. Finally, he is the host of the Scoliosis World podcast, where he breaks down the latest research on spinal flexibility, patient management, predictive scoliosis modeling, and functional medicine strategies specific to scoliosis patients.    Connect with Dr. Mark Morningstar: Website: https://www.backgenius.com/, https://scoliosispractice.com/ YouTube: https://www.youtube.com/@ScoliosisWorld Podcast: https://www.podbean.com/podcast-detail/hx3dd-1bb9e8/Scoliosis-World-w-Dr-Morningstar-Podcast   Want to try Breathwork? My Regulate and Restore Breathwork classes are a 4-week guided breathwork series designed to calm your nervous system and help you feel grounded, balanced and safe in your body. If you're feeling anxious, overwhelmed, low on energy or constantly on edge, this series uses gentle, intentional breathing to shift you out of stress and into true rest and regulation. You'll learn practical tools to calm your mind, restore your energy and build lasting nervous system resilience. Join us for one class or all 4 classes.  Can't make it live? That's ok, a replay will be emailed to you. Use the code 'PODCAST' at checkout to get 50% off your first class! Check it out and join here.     Sign up to our weekly newsletter and become an M&M Insider! You'll receive special discounts, bundles, behind the scenes podcast insights and simple tips to help you improve your health. Don't miss out!  Join here: https://www.mindmovementhealth.com.au/subscribe/   Connect with Kate: Website: MindMovementHealth.com.au Facebook: facebook.com/MindMovementHealth Instagram: instagram.com/MindMovementHealth Haven't subscribed to the podcast yet? Be sure to subscribe and leave us a review at: Apple Podcasts

Avoiding beans because of kidney stones? This episode is for you! Melanie dives into all the reasons beans are actually GOOD for most people with kidney stones - and the importance of eating them in a healthy well-balanced diet. Blog: Low Oxalate Beans Blog: Potential Renal Acid Load Blog: Magnesium & Kidney Stones Rodriguez A, Curhan GC, Gambaro G, Taylor EN, Ferraro PM. Mediterranean diet adherence and risk of incident kidney stones. The American Journal of Clinical Nutrition. 2020;111(5):1100-1106. Submit a question for Melanie to answer on the podcast! Connect with The Kidney Dietitian! Work with Us! |  Instagram | Facebook | Pinterest | Facebook Group | Newsletter www.thekidneydietitian.org FREE Webinar: The 3-Step Method to Prevent Kidney Stones   All information in this podcast is meant for educational purposes only and should not be used in place of advice from a medical professional.  

In this episode of Optimal Metabolism, I sit down with Dr. Michael Biamonte, founder of the Biamonte Center for Clinical Nutrition and author of The Candida Chronicles, to unpack the surprising connection between Candida overgrowth and metabolic dysfunction. Candida is often reduced to "just a yeast infection," but Dr. Biamonte explains why chronic fungal overgrowth can disrupt insulin signaling, impair liver detoxification, drive inflammation, weaken immunity, and create the perfect storm for weight gain, fatigue, high cholesterol, and blood pressure issues. If you've ever felt like your body is working against you, this conversation may connect the dots. You may want to explore this deeper if you experience: Stubborn weight loss resistance Blood sugar swings or insulin resistance Chronic fatigue or brain fog Recurrent infections Bloating, digestive complaints, or food sensitivities Hormonal imbalances that don't improve with diet alone

Samstagnachmittag, Supermarkt. Überall prangt das Wort „Protein“. Auf dem Joghurt, dem Milchreis, sogar auf den Nudeln. Und dann dieser Gedanke: Wenn Protein wirklich den Stoffwechsel ankurbelt – ist das der ultimative Geheimtrick zum Abnehmen?Eine aktuelle Meta-Analyse hat 52 Studien mit über 1.200 Teilnehmern ausgewertet, um genau das herauszufinden. Die Ergebnisse sind überraschend – und für Deine Ernährungsstrategie Gold wert.In dieser Folge erfährst Du:Warum der thermische Effekt von Protein in der Praxis massiv überschätzt wird – und welche Zahlen wirklich dahintersteckenWas eine proteinreiche Ernährung langfristig in Deinem Körper verändert (und warum es nicht der Kalorienverbrauch ist)Warum mein Klient Thomas mit 200 Gramm Protein am Tag trotzdem zunahm – und was Du daraus lernen kannstDie Protein-Anker-Methode und 5 weitere Quick Wins für Deinen AlltagWann mehr Protein wirklich nötig ist – und wann es nichts bringtWenn Du eine einzige Sache aus dieser Folge mitnimmst, dann diese: Protein ist beim Abnehmen Dein bester Freund – aber aus einem gänzlich anderen Grund, als Du bisher dachtest. Und Du erfährst, welcher das ist.____________*WERBUNG: Infos zum Werbepartner dieser Folge und allen weiteren Werbepartnern findest Du hier.____________Erwähnte Ressourcen und mehr zum Thema:Folge 490: Darmprobleme: Liegt's am Eiweiß? — mit Dr. med. Elke MantwillFolge 543: Die Protein-Lüge: Warum offizielle Empfehlungen Dich schwach haltenKalorienrechner auf marathonfitness.deMarks Proteinpulver-EmpfehlungenLiteratur:Guarneiri LL, et al. (2024). Effects of Varying Protein Amounts and Types on Diet-Induced Thermogenesis: A Systematic Review and Meta-Analysis. Advances in Nutrition, 15(12), 100332.Morton RW, et al. (2018). A systematic review, meta-analysis and meta-regression of the effect of protein supplementation on resistance training-induced gains in muscle mass and strength in healthy adults. British Journal of Sports Medicine, 52(6), 376–384.Helms ER, et al. (2014). A systematic review of dietary protein during caloric restriction in resistance trained lean athletes: a case for higher intakes. International Journal of Sport Nutrition and Exercise Metabolism, 24(2), 127–138.Wycherley TP, et al. (2012). Effects of energy-restricted high-protein, low-fat compared with standard-protein, low-fat diets: a meta-analysis of randomized controlled trials. American Journal of Clinical Nutrition, 96(6), 1281–1298.Moon J, Koh G. (2020). Clinical Evidence and Mechanisms of High-Protein Diet-Induced Weight Loss. Journal of Obesity & Metabolic Syndrome, 29(3), 166–173.Pesta DH, Samuel VT. (2014). A high-protein diet for reducing body fat: mechanisms and possible caveats. Nutrition & Metabolism, 11(1), 53.Quatela A, et al. (2016). The Energy Content and Composition of Meals Consumed after an Overnight Fast and Their Effects on Diet Induced Thermogenesis: A Systematic Review, Meta-Analyses and Meta-Regressions. Nutrients, 8(11), 670.Westerterp KR. (2004). Diet induced thermogenesis. Nutrition & Metabolism, 1(1), 5.Layman DK, et al. (2009). A moderate-protein diet produces sustained weight loss and long-term changes in body composition and blood lipids in obese adults. Journal of Nutrition, 139(3), 514–521.____________Shownotes und Übersicht aller Folgen.Trag Dich in Marks Dranbleiber Newsletter ein.Entdecke Marks Bücher.Folge Mark auf Instagram, Facebook, Strava, LinkedIn. Hosted on Acast. See acast.com/privacy for more information.

Nutrition Nugget! Bite-sized bonus episodes offer tips, tricks and approachable science. This week, Jenn is talking about zero-calorie drinks and whether they are really the guilt-free option we have been led to believe. A well-known Copenhagen study compared four groups of people who drank a liter a day of regular soda, diet soda, milk, or water for six months, and the results were surprising enough to stop anyone mid-sip. Could a beverage with absolutely no calories still be working against your blood sugar, waistline and your metabolism? What do your gut, your pancreas, and even your taste buds have to do with it? Jenn digs into the science, questions the study's details, and shares what she has seen play out in real life with herself and her clients for years. But before you toss your diet soda or defend it to the end, you should hear what Jenn has to say about who this affects, why, and whether the calorie count on the label is telling you anywhere near the whole story. Like what you're hearing? Be sure to check out the full-length episodes of new releases every Wednesday. Have an idea for a nutrition nugget? Submit it here: https://asaladwithasideoffries.com/index.php/contact/ RESOURCES:Become a Happy Healthy Hub MemberJenn's Free Menu PlanA Salad With a Side of FriesA Salad With A Side Of Fries MerchA Salad With a Side of Fries InstagramNutrition Nugget: IQ MixCopenhagen StudyKEYWORDS: Jenn Trepeck, Nutrition Nugget, Salad With A Side Of Fries, Health Tips, Wellness Tips, Zero Calorie Drinks, Diet Soda, Artificial Sweeteners, Aspartame, Insulin Response, Blood Sugar, Weight Gain, Gut Microbiome, Metabolic Health, Calorie Counting, Sugar Cravings, Glucagon, Pancreas, Glucose, Fat Burning, Gut Bacteria, Sweet Taste Addiction, Copenhagen Study, American Journal of Clinical Nutrition, Diet Cola, Regular Soda, Sugar Soda, Milk, Water Intake, BMI, Non-Diabetic Subjects, Weight Loss, Caloric Beverages, Nutrition Research, Food Cravings, Hormones, Insulin Levels, Blood Pressure, Overweight, Obese, Beverage Choices, Wellness, Weight Management, Health Coaching, Microbiome, Nutrition Science, Zero Calorie Drinks And Weight Gain, Do Diet Sodas Cause Insulin Response

Is fasting really the best way to lose fat — or is there a smarter, more strategic approach? In this masterclass episode, Vanessa introduces a powerful new concept: Protein Fasting — a structured approach using PSMF (Protein-Sparing Modified Fast) days to optimize fat loss, suppress appetite naturally, protect muscle, and potentially tap into fasting-like cellular signaling.

Don't Forget About Ignite!  https://fitwomensweekly.com/lp/fww-live/ignite-30/ A little about Nicolette, besides being one of the most intriguing women I've ever talked to...  She founded NutriSource Inc. in 2002 to provide high quality education, counseling and nutrition services for a diverse community population.  Prior to founding NutriSource Inc, she served as Director of Clinical Nutrition at the NYHQ/Silvercrest Center where she provided both administrative and direct care for sub-acute and chronically ill patients. Nicolette was a key member of performance improvement projects and as Chair of the Nutrition Committee; significant positive changes were made in the standard of care. She is also a contributing writer for Minerva Place, as well as an adjunct professor of Nutrition at CUNY and Touro Colleges. She believes in emphasizing a holistic approach toward food, nutrition and preventative healthcare. Connect with Nicolette Pace: https://nicolettepace.com/  Treat FWW With A Coffee: buymeacoffee.com/fitwomensweekly IG: https://www.instagram.com/kindalboylefitness/  Email: Kindal@fitwomensweekly.com  YT: https://www.youtube.com/@Fit-Womens-Weekly  TT: https://www.tiktok.com/@trainerkindal 

If you want to get leaner and live longer check out https://milliondollarbodylabs.com Is your healthy routine feeding hidden infections that cause brain fog and bloating? Why do most probiotics fail to fix a damaged gut? I talk with Dr. Michael Biamonte about Candida and dysbiosis. He explains how he used engineering to reverse engineer illness. We discuss how Candida mutates to survive and why rotating herbs every four days stops the cycle. He shares why iron and vitamin D feed infections. We cover the link between gut issues and autoimmune conditions. He details how biocybernetics identifies imbalances. He highlights the need to clear toxins before adding probiotics. We explore how to find the cause of health issues instead of covering symptoms with medications. Key Takeaways Rotate different antifungal herbs every four days to prevent Candida from mutating and becoming drug-resistant. Antifungals create oxidative stress, so taking antioxidants like Vitamin A or CoQ10 during treatment can stop them from working. Lower the Candida load before taking probiotics because the fungus repels bacteria through polarity. Candida needs iron and Vitamin D to survive, so taking these supplements during an active infection may feed the fungus. Dysbiosis blocks detoxification pathways, making it difficult for cleanses to work until the biome is corrected. Leaky gut syndrome allows toxins and proteins to enter the bloodstream, which triggers most autoimmune conditions. Biocybernetics uses blood and urine tests to analyze physiological self-regulation and find imbalances before they become diseases. Symptoms like brain fog and bloating often follow a specific progression from digestion issues to memory loss and rashes. "You don't have a drug deficiency"; medications typically mask symptoms rather than fixing the underlying imbalance. Resources Dr. Michael Biamonte's Book: The Candida Chronicles https://www.amazon.com/Candida-Chronicles-Mannual-Yeast-infections/dp/0692756191 Dr. Michael Biamonte's Websites: The Biamonte Center for Clinical Nutrition https://health-truth.com New York City Thyroid Doctor https://www.newyorkcitythyroiddoctor.com New York City Candida Doctor https://www.newyorkcitycandidadoctor.com Nate Palmer: The founder of The Million Dollar Body and author of "The Million Dollar Body Method", Nate has been coaching for over 15 years and has worked personally with over 1,000 clients. Website: https://milliondollarbodylabs.com Book: The Million Dollar Body Method Lean Energy Stack: https://milliondollarbodylabs.com/pages/lean Instagram: @_milliondollarbody  

The panel opens with credentials clarification and personal stories highlighting how U.S. medicine prioritizes drugs over lifestyle solutions. #MedicalReform #PillCulture #LifestyleMedicine #HealthTalks

Dr. Oscar Coetzee has over 25 years of experience in psychology and nutrition and is currently serving as the VP of Clinical Education and Practitioner Support at Designs for Health. His academic credentials include faculty positions at Georgetown Medical School, Notre Dame University, and the University of Bridgeport. Born and raised in South Africa, Dr. Oscar's educational background includes bachelor's degrees in criminology and psychology, master's degrees in Psychology and Human Nutrition, a PhD in Holistic Nutrition, and a Doctorate of Clinical Nutrition. He is recognized as a pioneer in nutritional science, focusing on metabolic syndrome, intestinal permeability, type 2 diabetes, sports performance, and chronic inflammatory diseases. In this episode, Tara sits down with Dr. Oscar Coetzee of Designs for Health to explore how gut health, genetics, and nutrition intersect with anxiety, depression, and overall mental wellness. They unpack keystone gut microbes, LPS and leaky gut, why whole‑food diets and polyphenols matter, and how functional labs like stool and organic acid tests can guide targeted support. Dr. Coetzee also explains the limits of DNA‑only protocols, the concept of "psychoneutrogenomics," and the expanding lab and education resources available for therapists, health coaches, and other practitioners.   RESOURCES: Learn more about Dr. Coetzee here: https://www.designsforhealth.com/ Instagram: @designsforhealth Get 15% off Peluva minimalist shoe with coupon code COACHTARA here: http://peluva.com/coachtara   CHAPTERS: 00:00 – Intro & Who Is Dr. Oscar Coetzee? 03:40 – Sponsor Segment: Peluva Minimalist Shoes 07:10 – From Psychiatry to Nutrition & "Psychoneutrogenomics" 14:20 – Gut Microbiome Basics and Mental Health Connection 21:30 – Keystone Anaerobes: Akkermansia, Roseburia & Friends 27:30 – LPS, Leaky Gut, Anxiety and Depression 33:40 – Genetics, Neurotransmitters and Why DNA Isn't Destiny 42:30 – Functional Testing Roadmap for Mood Issues 49:10 – Tools & Labs for Practitioners at Designs for Health 52:10 – Final Takeaways for Supporting Mental Health via the Gut   WORK WITH TARA: Are You Looking for Help on Your Wellness Journey? Here's how Tara can help you: TRY THE APP FOR FREE: http://taragarrison.com/app INDIVIDUAL ONLINE COACHING: https://www.taragarrison.com/work-with-me CHECK OUT HIGHER RETREATS: https://www.taragarrison.com/retreats   SOCIAL MEDIA:  Instagram @coachtaragarrison TikTok @coachtaragarrison Facebook @coachtaragarrison Pinterest @coachtaragarrison   INSIDE OUT HEALTH PODCAST SPECIAL OFFERS: ☑️ Upgraded Formulas Hair Test Kit Special Offer: https://bit.ly/3YdMn4Z ☑️ Upgraded Formulas - Get 15% OFF Everything with Coupon Code INSIDEOUT15: https://upgradedformulas.com/INSIDEOUT15 ☑️ Rep Provisions: Vote for the future of food with your dollar! And enjoy a 15% discount while you're at it with Coupon Code COACHTARA: https://bit.ly/3dD4ZSv   If you loved this episode, please leave a review! Here's how to do it on Apple Podcasts: Go to Inside Out Health Podcast page: https://podcasts.apple.com/us/podcast/inside-out-health-with-coach-tara-garrison/id1468368093 Scroll down to the 'Ratings & Reviews' section. Tap 'Write a Review' (you may be prompted to log in with your Apple ID). Thank you!

Luke Hanna holds a Master's degree in Obesity and Clinical Nutrition and a degree in Sport and Exercise Science. He has become one of my favourite authorities on evidence-based nutrition.Luke joins the podcast to break down the controversy surrounding the new American food pyramid - what it gets right, where it falls short, and why most people won't follow it regardless.THIS EPISODE COVERS:The attention and controversy surrounding the new American food pyramidWhat the updated pyramid gets wrongWhat it gets rightInconsistencies in the pyramid and media messagingWhether the new pyramid has been misrepresented compared to the old oneWhether people actually follow official governmental food guidesWhy Luke shifted his beliefs on saturated fat and LDL cholesterol — and what the evidence actually saysWhether strength training or cardio meaningfully increase appetite and lead to “eating back” burned caloriesCommon narratives around not needing fibreThe benefits of eating more fibreWhy restricting calories earlier in the day before a special occasion can sometimes backfireAnd much moreInstagram: @lukehannanutritionCHAPTERS00:38 Discussion on the New Food Pyramid03:03 Critique of the Guidelines04:49 Misrepresentation and Public Perception13:00 Alcohol Guidelines and Corporate Influence16:49 Practical Advice for Following Guidelines21:12 Policy Changes for Better Health23:32 Personal Reflections on Nutrition Beliefs27:50 Introduction to the Keto CTA Study28:40 Misrepresentation of Study Data29:16 The Importance of Context in Nutrition35:44 Exercise and Appetite: Myths and Facts41:53 Calorie Banking: Does It Work?45:56 The Benefits of Fibre50:04 Conclusion and Final ThoughtsSUPPORT THE SHOWIf this episode helped you think more clearly about nutrition guidelines and media messaging, you can support the show by:Subscribing and checking out more episodesSharing it on social media (tag me — I will respond)Sending it to someone confused about dietary guidelinesFOLLOW ANDREW COATESInstagram: @andrewcoatesfitnesshttps://www.andrewcoatesfitness.comPARTNERS AND RESOURCESRP Strength App (use code COATESRP)https://www.rpstrength.com/coatesJust Bite Me Meals (use code ANDREWCOATESFITNESS for 10 percent off)https://justbitememeals.com/MacrosFirst – FREE Premium TrialDownload MacrosFirstDuring setup, answer: How did you hear about us?Type: ANDREWKNKG Bags (15 percent off)https://www.knkg.com/Andrew59676Versa Gripps (discount link)https://www.versagripps.com/andrewcoatesTRAINHEROIC – FREE 90 Day Trial (2 steps)Go to: https://www.trainheroic.com/liftfreeReply to the email you receive (or email trials@trainheroic.com) and let them know Andrew sent you

In the latest episode of the Plant-Based Podcast, we breakdown some of the confusion generated by the new Dietary Guidelines for Americans with Dr. Kevin Klatt. Dr. Klatt is an Assistant Professor in the Department of Nutritional Sciences in the Temerty Faculty of Medicine at the University of Toronto.He received his PhD in Molecular Nutrition from Cornell University and completed his clinical dietetic (RD) training at the National Institutes of Health Clinical Center. His research focuses on using both preclinical models as well as human intervention studies to better understand nutrient metabolism, signaling and requirements.In addition to research, Dr. Klatt is a current Associate Editor at the American Journal of Clinical Nutrition and a Section Editor of the graduate-level nutrition textbook, Biochemical Physiological and Molecular Aspects of Human Nutrition (fifth edition).Dr. Klatt dissects some of the big ticket changes to the DGAs, including the recommendation to increase protein and saturated fat intake, confusion around processed foods, and inconsistencies between the revamped pyramid model and the actual recommendations.ResourcesKevin's Substack on the DGAs: The Influencer's DGAs & The Rancher's Pyramid Twitter BlueSky Instagram Bonus PromotionCheck out University of Guelph's online Plant-Based Nutrition Certificate. Each 4-week course will guide you through essential plant-based topics including nutritional benefits, disease prevention, and environmental impacts. You can also customize your learning with unique courses such as Plant-Based Diets for Athletes and Implementing a Plant-Based Diet at Home. As the first university-level plant-based certificate in Canada, you'll explore current research, learn from leading industry experts, and join a community of like-minded people. Use our exclusive discount code PBC2026 to save 10% on all Plant-Based Nutrition Certificate courses. uoguel.ph/pbn.Support the show

Takeaways* Sustainable lifestyle habits are crucial for busy professionals.* Travel can disrupt routines, making it harder to maintain healthy habits.* Sleep is essential for overall health and cognitive function.* Stress management techniques include meditation, exercise, and breaks.* Social connections play a vital role in mental well-being.* Mindfulness in nutrition can lead to better health outcomes.* Not all calories are equal; focus on nutrient-dense foods.* Listening to your body is key to understanding your health needs.* A supportive community can enhance accountability in health journeys.* Small, incremental changes are more sustainable than drastic shifts.Chapters00:00 Introduction to Health and Wellness Coaching02:33 The Impact of Travel on Routine05:39 The Importance of Sleep10:54 Stress Management Techniques14:28 The Role of Social Connection19:44 Navigating Social Media and Its Effects23:57 The Difference Between Health and Wellness28:57 The Interplay of Health and Wellness33:29 Overcoming Barriers to Wellness37:08 Nutrition: A Key Component of Wellness40:27 Understanding Food Sensitivities45:09 The Role of Carbohydrates in Diet49:29 Calories: Quality vs. Quantity53:00 Listening to Your Body56:39 The Importance of Continuous LearningTess Cheng is a certified health and wellness coach with over 13 years of experience helping high-performing individuals with demanding schedules build sustainable habits that support long-term success. Drawing from her personal experience with hypoglycemia and a family history of diabetes, Tess takes a holistic approach to lifestyle change, one that integrates nutrition, mindset, self-care, disease prevention, and longevity.With a Master's degree in Clinical Nutrition from NYU, she translates science into practical, real-world strategies that fit busy lives. Tess believes wellness isn't a luxury, it's a foundation for peak performance, resilience, and success both professionally and personally.Connect With Tess:https://glowithtess.com/https://www.linkedin.com/in/tess-cheng-mshttps://www.instagram.com/glowithtess/https://www.facebook.com/TessCheng888/https://tinyurl.com/GWTSleepGuideCody's content: https://linktr.ee/cjones803#podcast #purewisdompodcast #personalgrowth #motivation #mindset #facingfears #selfidentity #inspiration #selfimprovement #psychology #entrepreneurship #fitness #fitnessmotivation #business #career #dating #relationships #lifecoach #healthandwellness #workout #coaching #health, #wellness, #nutrition, #sleep, #stressmanagement, #socialconnection, #lifestylehabits, #mindfulness, #self-careDisclaimer: Any information discussed in this podcast is for entertainment purposes only and is not intended to act as a substitute for professional, medical, legal, educational, or financial advice. The following views and opinions are those of the individual and are not representative views or opinions of their company or organization. The views and opinions shared are intended only to inform, and discretion and professional assistance should be utilized when attempting any of the ideas discussed. Pure Wisdom Podcast, LLC, its host, its guest, or any company participating in advertising through this podcast is not responsible for comments generated by viewers which may be offensive or otherwise distasteful. Any content or conversation in this podcast is completely original and not inspired by any other platform or content creator. Any resemblance to another platform or content creator is purely coincidental and unintentional. No content or topics discussed in this podcast are intended to be offensive or hurtful. Pure Wisdom Podcast, LLC, its host, its guest, or any company participating in advertising through this podcast is not responsible for any misuse of this content.

In this research-focused episode, Dr. Scott Watier and Tommy Welling break down a groundbreaking four-week study from the Journal of Clinical Nutrition comparing alternate day fasting (true zero-calorie fasting days alternating with unrestricted eating days) against standard 16:8 time-restricted eating, revealing that ADF produced £1.4 more total fat loss and significantly greater visceral fat reduction than daily intermittent fasting—the stubborn metabolic fat that drives disease. The hosts emphasize the surprising finding that the ADF group was the only one showing increased activity energy expenditure and improved quality of life scores despite being in an aggressive caloric deficit, demonstrating that people actually felt better and moved more naturally rather than experiencing the typical diet misery. They provide crucial context on metabolic adaptation, explaining why the slight decrease in resting metabolic rate and T3 thyroid hormone with ADF only becomes problematic if prolonged, which is why they recommend strategic 2-4 week ADF cycles followed by foundational 16:8 or 18:6 fasting to protect metabolism while still achieving powerful visceral fat loss. This episode delivers the practical framework for using ADF as an intermittent power tool within a sustainable fast-cycling lifestyle—not as a white-knuckle permanent strategy like Angus Barbieri's 382-day fast or repeated brutal 72-hour fasts—while protecting muscle mass through resistance training and adequate protein to create lasting body composition changes without sacrificing energy, sanity, or long-term metabolic health. ⁠Take the NEW FASTING PERSONA QUIZ! - The Key to Unlocking Sustainable Weight Loss With Fasting!⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Resources and Downloads: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠SIGN UP FOR THE DROP OF THE ULTIMATE GUIDE TO BLOOD SUGAR CONTROL⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠GRAB THE OPTIMAL RANGES FOR LAB WORK HERE! - NEW RESOURCE! ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠FREE RESOURCE - DOWNLOAD THE NEW BLUEPRINT TO FASTING FOR FAT LOSS!⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠SLEEP GUIDE DIRECT DOWNLOAD⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠DOWNLOAD THE FASTING TRANSFORMATION JOURNAL HERE!⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Partner Links: Get your⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ FREE BOX OF LMNT⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ hydration support for the perfect electrolyte balance for your fasting lifestyle with your first purchase⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ here!⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Get ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠25% off a Keto-Mojo⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ blood glucose and ketone monitor (discount shown at checkout)! ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Click here!⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Our Community: Let's continue the conversation. Click the link below to JOIN the ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Fasting For Life Community⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠, a group of like-minded, new, and experienced fasters! The first two rules of fasting need not apply! If you enjoy the podcast, please tap the stars below and consider leaving a short review on Apple Podcasts/iTunes. It takes less than 60 seconds, and it helps bring you the best original content each week. We also enjoy reading them! Article Links: https://www.clinicalnutritionjournal.com/action/showPdf?pii=S0261-5614%2825%2900247-X

In This Episode: [4:40] How Dr. Biamonte became “The Candida King”[7:15] Why probiotics make Candida symptoms worse[10:00] Nutrients that actually feed the growth of Candida[12:25] Candida and copper[14:13] What triggers Candida overgrowth, and how to test for it[19:00] Address Candida first, then tackle other co-factors[22:25] When to test for mercury[23:28] Rotating antifungals in the Candida detox protocol [28:05] How long does it take to get rid of Candida overgrowth?[29:30] When to reincorporate probiotics after a Candida detox protocol[30:43] The Candida diet - what's true and what's not?[32:48] Supporting the lymphatic system and liver during Candida die-off[34:05] Can Candida cause hypothyroidism?[37:15] What people don't understand about the thyroid and CandidaCan Candida cause hypothyroidism? Why does Candida keep coming back after treatment? This week, I'm thrilled to introduce Dr. Michael Biamonte, founder of the Biamonte Center for Clinical Nutrition to answer these questions, and more. Dr. Biamonte has spent three decades dedicating his career to improving lives through stopping Candida overgrowth through functional nutrition and lab testing. Today, we dive into the intricacies of Candida, its connection to thyroid issues, and the science behind his five-phase candida treatment protocol. Dr. Biamonte walks us through the critical relationship between Candida and thyroid issues, elaborating on how it can often be the root cause of many symptoms women struggle with for years before receiving proper care. We discuss the importance of proper sequencing in treatment plans, highlighting why it's beneficial to tackle Candida before addressing heavy metals and other toxins. Dr. Biamonte also reveals why conventional antifungals often fail patients and shares his insights on effective Candida treatments, like rotating antifungals and monitoring progress through innovative urine tests.In addition to tackling Candida, we discuss the role of minerals, especially through Hair Tissue Mineral Analysis (HTMA), and how it complements understanding and treating Candida overgrowth. Dr. Biamonte also sheds light on maintaining the balance in the gut ecosystem through targeted probiotic use and explains why the Candida diet needs to be low in carbohydrates and sugars. If you or someone you know is struggling with Candida, thyroid issues, or both, this episode offers a wealth of knowledge and hope for effective treatments and better health. Join me as we uncover the science, challenges, and solutions in managing Candida with one of the leading experts in the field. And as always, please share this episode with anyone who could benefit from understanding more about Candida and its impact on overall health.Disclaimer:...

Brenda Davis opens with powerful evidence that type 2 diabetes is not a life sentence—covering remission data, the Twin Cycles hypothesis, and groundbreaking trials showing reversal with diet. #DiabetesReversal #PlantBasedHealth #TwinCycles

Can You Get the Benefits of a 5-Day Fast Without Starving?Click On My Website Below To Schedule A Free 15 Min Zoom Call:www.Over40FitnessHacks.comOver 40 Fitness Hacks SKOOL Group!Get Your Whoop4.0 Here!Ashley Bizzell - Registered Dietitianwww.L-NutraHealth.comProlon Fast Mimicking DietIn this episode, Brad Williams sits down with Ashley Bizzell, Registered Dietitian and Director of Clinical Nutrition and Global Training at L-Nutra Health, the company behind ProLon®, to dive deep into fasting, metabolic health, and the science behind the Fast Mimicking Diet (FMD).Ashley explains how she transitioned into clinical nutrition and now leads the medical arm of L-Nutra Health, which supports patients with metabolic conditions like prediabetes, obesity, high cholesterol, and type 2 diabetes through evidence-based nutrition therapy, telehealth physicians, and structured fasting programs. While ProLon is often viewed as a “fasting product,” Ashley reframes it as a nourishing technology designed to deliver the benefits of prolonged fasting—without the risks of complete food deprivation.Brad and Ashley break down what the Fast Mimicking Diet actually is: a precisely formulated 5-day program that provides real food—soups, bars, olives, teas, and healthy fats—while keeping the body in a fasting state. The conversation explores how the FMD supports autophagy, cellular cleanup, metabolic flexibility, and insulin sensitivity, while also offering muscle protection, a major concern for adults over 40.Brad shares his personal experience with water fasting, intermittent fasting, and ProLon, comparing fat loss, insulin control, ketosis depth, and autophagy. Ashley explains why ProLon is structured for five days, how autophagy ramps up around day three, and why day six refeeding with high-quality whole foods is just as critical as the fast itself.They also discuss:The role of fasting in reducing inflammation, improving lipid panels, liver health, insulin resistance, and even taste and smell sensitivityHow ProLon supports muscle preservation through targeted nutrients like glycerolWhy fasting is a positive, hormetic stress similar to exerciseThe importance of metabolic flexibility and why fasting gets easier over timeHow continuous glucose monitors (CGMs) can provide personalized insight into food responsesThe growing acceptance of fasting and food-as-medicine in mainstream healthcare, including L-Nutra's recent recognition by the American Diabetes Association for improvements in A1C and medication reductionAshley also highlights additional L-Nutra products, including vegan protein shakes and bars that support muscle without triggering aging pathways, as well as one-day fasting resets for beginners.If you're interested in online personal training or being a guest on my podcast, "Over 40 Fitness Hacks," you can reach me at brad@over40fitnesshacks.com or visit my website at:www.Over40FitnessHacks.comAdditionally, check out my Yelp reviews for my local business, Evolve Gym in Huntington Beach, at https://bit.ly/3GCKRzV

Today, I am delighted to be joined by a friend and colleague, Mike Mutzel.  Mike has a master's in Clinical Nutrition from the University of Bridgeport. He is a graduate of the IFM, applies functional medicine in clinical practice, and is a consultant lecturer who teaches leading-edge science in a concise format for progressive clinicians to prevent chronic diseases.  In our discussion, Mike and I unpack the benefits of creatine monohydrate, highlighting the importance of ensuring the products we use are free of impurities. We explain how creatine monohydrate gets created, answer many listener questions, and describe current research specific to creatine monohydrate, discussing ways to support bone health, navigate dosing, and how to troubleshoot.  This conversation with Mike Mutzel is truly invaluable, and I look forward to having him back on the podcast to dive a little deeper into the science.  IN THIS EPISODE, YOU WILL LEARN: How creatine supports energy production across muscles, the brain, and other organ systems Why vegetarians and vegans should take creatine What to consider when choosing high-quality creatine supplements Dosing strategies based on diet, exercise, sleep, and individual needs How taking creatine with electrolytes while exercising can improve absorption Benefits of supplementing with amino acids alongside creatine for illness, recovery, or when protein intake is low Adjusting your creatine dosage for sleep, travel, or exercise demands How creatine supports bone and muscle health  The value of creatine for the eyes and ears Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Connect with Mike Mutzel On his website YouTube Instagram High Intensity Health Podcast Creatine Research: Creatine in Women's Health: Bridging the Gap From Menstruation Through Pregnancy to Menopause Effects of Creatine and Resistance Training on Bone Health in Postmenopausal Women Creatine Supplementation (3 g/d) and Bone Health in Older Women: A 2-Year, Randomized, Placebo-Controlled Trial Creatine Supplementation in Depression: A Review of Mechanisms, Efficacy, Clinical Outcomes, and Future Directions The Effects of 8-Week Creatine Hydrochloride and Creatine Ethyl Ester Supplementation on Cognition, Clinical Outcomes, and Brain Creatine Levels in Perimenopausal and Menopausal Women (CONCRET-MENOPA): A Randomized Controlled Trial

It's wild how easily alcohol becomes part of our routine, especially in midlife, yet so many women quietly wonder why their sleep, mood, or hormones suddenly feel out of sync. In this episode, we get real about what alcohol is actually doing behind the scenes and how a few simple nutrition shifts can change the way you feel (and even what you crave). I'm sitting down with Dr. Brooke Scheller, a Doctor of Clinical Nutrition and Founder of Functional Sobriety, whose work is helping women rethink their drinking habits with compassion and curiosity.   Dr. Brooke opens up about her own sobriety journey and the surprising link she discovered between food and alcohol cravings. We break down the myth of "healthy" drinking, talk through why midlife hormones can make alcohol hit harder, and share the small swaps that make cutting back feel a lot less intimidating.   You'll hear insights that make you feel empowered, not judged, about what's going on in your body and why giving yourself a little more support can make a huge difference in your energy, mood, and clarity. And if you want a little extra help this season, grab my Free Holiday Recipe Guide filled with cozy, hormone-friendly dishes that taste like tradition without the crash, and hop on the 2025 VIP Hot List to be the first to know when my Black Friday deals go live.   Key Timestamps: [00:00:00] Introduction. [00:04:43] Alcohol consumption and the Gen Z [00:06:06] Should you really drink alcohol? [00:07:35] Alcohol's impact on midlife stress. [00:12:41] Gut health and sobriety. [00:21:11] Alcohol's impact on hormone balance. [00:23:07] Alcohol as a macronutrient. [00:28:23] Cravings and willpower connection. [00:31:41] Nutrient depletion and cravings. [00:36:31] Nutrient deficiencies and health. [00:38:50] Understanding cravings and nutrition. [00:43:33] The power of reducing alcohol. [00:47:08] Simple steps to take if you want to reduce alcohol.    Memorable Quotes:  "I really challenge people, and what I hope that people take away from this discussion is really just starting to think about what alcohol means to them." [00:08:46] – Dr. Brooke Scheller   "It wasn't until we unlocked that alcohol piece that everything else started falling into place." [00:46:25] – Dr. Brooke Scheller   Links Mentioned: Free Holiday Recipe Guide: https://dranna.com/holidayrecipes Black Friday 2025 VIP Hot List: https://dranna.com/deals How to Eat to Change How You Drink Book: https://a.co/d/6hjCXTE   Connect with Dr. Brooke Scheller: Website: http://www.functionalsobriety.com/ Instagram: https://www.instagram.com/drbrookescheller/   Connect with Dr. Anna Cabeca: Website: https://drannacabeca.com/pages/show Instagram: https://www.instagram.com/thegirlfrienddoctor/ YouTube: https://www.youtube.com/@thegirlfrienddoctor TikTok: https://www.tiktok.com/@drannacabeca   Produced by Evolved Podcasting: www.evolvedpodcasting.com

Grazing. Chronic stress. Poor sleep. Rushed meals. Sitting for long hours. Underfueled workouts. Estrogen decline. There's a lot more behind our fasting glucose and A1C than how many carbs we eat. This week we return to one of the most consistently requested topics: blood sugar meaning and management with Liz McKinney, CNS, LDN. We explore what glucose spikes really mean, why time-in-range and variability matter more than a single peak, and how stress, sleep, and even eating speed affect your numbers. We cover carb timing, meal sequencing, post-meal walks, creatine, why under-fueling can make exercise spikes worse, and much more so you can keep glucose working for your performance and overall health.Liz McKinney, CNS, LDN, heads up the clinical nutrition team at Nutrisense. Liz holds a Master of Science degree in Clinical Nutrition and Integrative Health and is a board-certified nutrition specialist (CNS) as well as a licensed dietitian nutritionist (LDN). In her time as a nutritionist, Liz has educated and counseled hundreds of clients in areas such as weight loss, hormonal imbalances, and gastrointestinal diseases. Her approach is rooted in the tenets of functional medicine, and she strives to identify the root cause of the issue instead of simply treating the symptoms. She realizes there is no one-size-fits-all approach to achieving optimal health and feels it is crucial to be in an equal partnership with her clients. Resources What to Know About Prediabetes and Menopause with Val Schonberg, RDN, CSSD (Episode 202)Sign up for our FREE Feisty 40+ newsletter: https://feisty.co/feisty-40/Join our Feisty Winter Training for Cyclists at https://feisty.co/ and look for the yellow banner at the top of the page. Use code HITPLAY50 to save $50 Learn More and Register for our 2026 Tucson Bike Camp: https://feisty.co/events/gravel-camp-x-bike-mechanic-school/ Follow Us on Instagram:Feisty Menopause: @feistymenopause Hit Play Not Pause Facebook Group: https://www.facebook.com/groups/807943973376099 Support our Partners:Midi Health: You Deserve to Feel Great. Book your virtual visit today at https://www.joinmidi.com/Previnex: Get 15% off your first order with code HITPLAY at https://www.previnex.com/ Nutrisense: Go to nutrisense.io/hitplay and use code: HITPLAY to get 30% offWahoo KICKR RUN: Use the code FEISTY to get a free Headwind Smart Fan (value $300) with the purchase of a Wahoo KICKR RUN at https://shorturl.at/maTzL

Today, I am honored to be in conversation with Dr. Brooke Scheller. She is a doctor of Clinical Nutrition, a nationally recognized health expert, and the founder of Functional Sobriety, a nutrition-based program for alcohol reduction. She also wrote How to Eat to Change How You Drink.  In our conversation today, we discussed the stigmatization of alcohol use and explored the nuances of curiosity and sobriety. We dispel common misconceptions, examine the research on alcohol consumption, tackle the definition of moderation, scrutinize the influence of industry ties, and unravel the issues linked to excessive alcohol consumption. Dr. Scheller also sheds light on how poor absorption affects the gut microbiome and contributes to a leaky gut, providing insightful nutritional strategies to address these concerns. Our conversation also extends to fertility, blood sugar, and the challenges posed by initiatives like Dry January and sober challenges.   Stay tuned for today's comprehensive exploration of the relationship between nutrition and alcohol use. IN THIS EPISODE YOU WILL LEARN: How the stigma surrounding alcohol use is changing How does alcohol affect the brain and body? How alcohol impacts the gut microbiome, intestinal permeability, and nutrient absorption Dr. Scheller shares her personal experience with alcohol  How alcohol consumption in middle-aged women could increase inflammation and oxidative stress How alcohol impacts blood sugar The link between alcohol consumption and male infertility  Some suggestions for navigating a Dry January How alcohol use impacts mental health Overcoming alcohol addiction through self-awareness and wellness Bio: Dr. Brooke Scheller DCN, CNS Dr. Brooke Scheller is a Doctor of Clinical Nutrition, the founder of Functional Sobriety, and the author of How to Eat to Change How You Drink. After finding freedom from alcohol in 2021, Dr. Brooke took her experience in sobriety and applied her expertise in nutrition and functional medicine to help others change their relationship with alcohol. Her approach results in improved brain health, mood, energy, focus, gut health, and hormone balance.  Her launch of Functional Sobriety led to the development of her online community, the Functional Sobriety Network, and several online programs with members across the globe. Functional Sobriety offers the first-ever custom supplement program for the sober and sober-curious. As a motivational speaker, Dr. Brooke helps to spread the word about functional nutrition, alcohol-free wellness, and the power of sobriety.  Connect with Cynthia Thurlow Follow on X, ⁠Instagram⁠ & ⁠LinkedIn⁠ Check out Cynthia's ⁠website⁠ Submit your questions to support@cynthiathurlow.com Connect with Dr. Brooke Scheller On her ⁠website⁠ ⁠Instagram⁠ (@drbrookescheller) ⁠Functional Sobriety⁠ How to Eat to Change How You Drink

A study published in the American Journal of Clinical Nutrition showed that eating two eggs daily lowered LDL cholesterol, while high saturated fat diets raised it Researchers found cholesterol from eggs did not raise LDL, but saturated fat from foods like bacon and sausage did, showing food context makes a major difference Eggs provide cholesterol without overloading the liver, allowing it to clear LDL efficiently and preventing artery buildup that increases heart disease and stroke risk Weekly egg intake reduced heart disease deaths by 29% and all-cause mortality by 17% in older adults, highlighting the importance of moderation for protective benefits Choosing pastured eggs, avoiding vegetable oils, and pairing eggs with nutrient-rich whole foods further boost benefits while minimizing harmful omega-6 linoleic acid (LA) intake