Podcasts about Medical microbiology

Superpowers for Good should not be considered investment advice. Seek counsel before making investment decisions. When you purchase an item, launch a campaign or create an investment account after clicking a link here, we may earn a fee. Engage to support our work.Watch the show on television by downloading the e360tv channel app to your Roku, AppleTV or AmazonFireTV. You can also see it on YouTube.Devin: What is your superpower?Nicole: Willingness to take bold leaps and embrace the unknown.Imagine a world where cancer is as treatable as the flu. That's the vision Nicole Paulk, the founder and CEO of Siren Biotechnology, is working tirelessly to bring to life. Driven by groundbreaking science, Nicole's company is on the brink of launching clinical trials for a revolutionary cancer treatment.Nicole's work leverages engineered viruses—those that don't make you sick—to deliver genetic medicines directly to cancer cells. These “good viruses” act as a delivery system for anti-tumor drugs, targeting difficult-to-treat cancers like recurrent high-grade gliomas, a fatal brain cancer. “We started to see data that looked really promising in this space,” Nicole explained, adding, “We felt a moral obligation to go after this cancer where there's just this huge unmet need.”Siren Biotechnology's approach is designed to have broad applications. Unlike treatments that target specific genetic mutations, their method has the potential to work on various tumor types. Nicole describes it as using viruses like a “little FedEx delivery truck” that can be engineered to deliver medicine precisely where it's needed in the body.This innovation didn't happen overnight. Nicole, a former professor of virology at UCSF, took the bold step of leaving academia to launch Siren Biotechnology. “I decided to resign from my faculty position and go be the founder and CEO just because I was so excited about the data and what we had so far,” she shared.In addition to traditional venture capital funding, Siren Biotechnology is inviting the public to invest through a regulated investment crowdfunding campaign. This unique opportunity allows patients, families, and supporters touched by cancer to be part of their journey. “We wanted to bring patients and their families onto our cap table,” Nicole said. “It's a way to involve them in the conversation much earlier.”Siren Biotechnology's work could redefine cancer care and inspire a new model for patient-centered innovation. With clinical trials just months away, the future looks brighter for those battling cancer—and for all of us who dream of a world where cancer is no longer a death sentence.tl;dr:Nicole Paulk's Siren Biotechnology transforms viruses into targeted cancer therapies with universal potential.The company focuses on recurrent high-grade gliomas, a fatal brain cancer with no standard treatment.Nicole left academia to lead Siren, leveraging her groundbreaking virology research to launch the company.Siren's unique crowdfunding campaign lets patients and families invest in the fight against cancer.Nicole's superpower, fearless innovation, drives her bold mission to revolutionize cancer care.How to Develop Fearless Innovation As a SuperpowerNicole's superpower is her willingness to take bold leaps and embrace the unknown. After spending nearly two decades building her academic career, Nicole left her position as a virology professor at UCSF to start Siren Biotechnology. She explained, “I feel like my superpower is just kind of being willing to jump off the cliff without a parachute and be like, we're going to figure it out. We're going to make it work.”Nicole exemplified fearless innovation when her research led to a groundbreaking discovery about the biology of a virus, one that required rewriting existing textbooks. Initially met with skepticism, her work was later validated and became a foundation for Siren Biotechnology's cancer treatment. This pivotal moment highlights Nicole's courage to challenge conventional knowledge and pursue transformative ideas.Tips for Developing This Superpower:Be willing to question conventional wisdom and explore new paths.Take calculated risks, even if it means stepping away from a well-defined career path.Embrace discomfort and uncertainty as a necessary part of innovation.Engage others by communicating your vision in relatable and accessible ways.By following Nicole's example and advice, you can make fearless innovation a skill. With practice and effort, you could make it a superpower that enables you to do more good in the world.Remember, however, that research into success suggests that building on your own superpowers is more important than creating new ones or overcoming weaknesses. You do you!Guest ProfileNicole Paulk (she/her):CEO, Founder, President, Siren BiotechnologyAbout Siren Biotechnology: We are combining two transformative therapeutic technologies – AAV gene therapy and cytokine immunotherapy – into a single, reimagined modality that overcomes key challenges and redefines how we destroy tumor cells and elicit anti-tumor immunity.This is the first AAV gene therapy drug product that can be made once and used in numerous indications – a huge leap forward for the field. This drastically reduces clinical development times, manufacturing timelines, and capital needs for each clinical trial. Most importantly, ‘universal' means countless solid tumor cancer patients – regardless of tumor type or mutations – may benefit from this breakthrough approach.Website: sirenbiotechnology.comX/Twitter Handle: @SirenBioCompany Facebook Page: facebook.com/SirenBiotechnologyOther URL: wefunder.com/siren.biotechnologyBiographical Information: Dr. Nicole Paulk is the CEO, Founder, and President of Siren Biotechnology and has dedicated her career to advancing the field of gene therapy. With nearly two decades of expertise, Nicole has been at the forefront of developing cutting-edge advances to propel the field of gene therapy forward for a wide range of diseases.Before founding Siren, Nicole held various leadership positions in academia and industry and most notably was an Assistant Adj Professor of AAV Gene Therapy in the UCSF Department of Biochemistry & Biophysics before leaving to found Siren. Nicole has a B.S. in Medical Microbiology, a Ph.D. in Viral Gene Therapy and Regenerative Medicine from OHSU, and completed her Postdoctoral Fellowship and Instructorship in Human Gene Therapy at Stanford University prior to starting her lab at UCSF. Nicole is a pioneer in the development of next-generation AAV platforms for gene repair, gene transfer and gene editing, directed evolution for novel engineered capsid evolution, and comparative multi-omic approaches to interrogate translational AAV biology.Nicole is a renowned expert in gene therapy and has consulted extensively for big pharma, written draft CMC guidance for the FDA, and sits on the Scientific Advisory Boards for Sarepta, Astellas, Metagenomi, Dyno Therapeutics, CEVEC, GRO Biosciences, Excision BioTherapeutics, WhiteLab Genomics, Johns Hopkins Gene Therapy Initiative, the Gene Therapy for Rare Disorders Searchlight Program, and several stealth startups. She has been quoted in The Wall Street Journal, The Economist, The Boston Globe, Endpoints, STAT, Phacilitate, GEN, BioPharma Dive, Evaluate Vantage, SF Business Times, WIRED, Drug Discovery World, MIT Tech Review, C&EN, and more. She sits on the Scientific Editorial Boards of the journals Gene Therapy, Human Gene Therapy, and Biopharma International Gene Therapy. She is the Chair of the American Society of Gene and Cell Therapy (ASGCT) Translational Science Committee, and a member of the ASGCT Cancer Cell and Gene Therapy Committee and the Biocom California Cell and Gene Therapy Committee. She has invented numerous AAV gene therapy technologies that have been shared or licensed to dozens of gene therapy companies and nonprofit groups working in rare diseases.Outside of work, you can find Nicole adventure traveling (think whitewater rafting meets backcountry trekking), snowboarding, planning elaborate Halloween parties complete with animatronics and ghoulish menus, tending her vegetable garden, and obsessing over the latest wearable gadgets. If you're trying to track her down at a conference and can't find her, it's because she snuck off to an oyster bar.X/Twitter Handle: @Nicole_PaulkLinkedin: linkedin.com/in/nicolepaulkInstagram Handle: @sirenbioSupport Our SponsorsOur generous sponsors make our work possible, serving impact investors, social entrepreneurs, community builders and diverse founders. Today's advertisers include FundingHope, Kingscrowd and Crowdfunding Made Simple. Learn more about advertising with us here.Max-Impact MembersThe following Max-Impact Members provide valuable financial support:Carol Fineagan, Independent Consultant | Lory Moore, Lory Moore Law | Marcia Brinton, High Desert Gear | Paul Lovejoy, Stakeholder Enterprise | Pearl Wright, Global Changemaker | Ralf Mandt, Next Pitch | Scott Thorpe, Philanthropist | Matthew Mead, Hempitecture | Michael Pratt, Qnetic | Sharon Samjitsingh, Health Care Originals | Add Your Name HereUpcoming SuperCrowd Event CalendarIf a location is not noted, the events below are virtual.Impact Cherub Club Meeting hosted by The Super Crowd, Inc., a public benefit corporation, on June 17, 2025, at 1:00 PM Eastern. Each month, the Club meets to review new offerings for investment consideration and to conduct due diligence on previously screened deals. To join the Impact Cherub Club, become an Impact Member of the SuperCrowd.SuperCrowdHour, June 18, 2025, at 12:00 PM Eastern. 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Thanks to sponsors DNA and DealMaker, this event is free to watch and amplifies the voices of underrepresented and mission-aligned entrepreneurs. Don't miss this inspiring evening where capital meets purpose—tune in to discover and support the next wave of impact-driven innovation.SuperCrowd25, August 21st and 22nd: This two-day virtual event is an annual tradition but with big upgrades for 2025! We'll be streaming live across the web and on TV via e360tv. Soon, we'll open a process for nominating speakers. Check back!Community Event CalendarSuccessful Funding with Karl Dakin, Tuesdays at 10:00 AM ET - Click on Events.Devin Thorpe is featured in a free virtual masterclass series hosted by Irina Portnova titled Break Free, Elevate Your Money Mindset & Call In Overflow, focused on transforming your relationship with money through personal stories and practical insights. June 8-21, 2025.Join Dorian Dickinson, founder & CEO of FundingHope, for Startup.com's monthly crowdfunding workshop, where he'll dive into strategies for successfully raising capital through investment crowdfunding. June 24 at noon Eastern. Regulated Investment Crowdfunding Summit 2025, Crowdfunding Professional Association, Washington DC, October 21-22, 2025.Call for community action:Please show your support for a tax credit for investments made via Regulation Crowdfunding, benefiting both the investors and the small businesses that receive the investments. Learn more here.If you would like to submit an event for us to share with the 9,000+ changemakers, investors and entrepreneurs who are members of the SuperCrowd, click here.We use AI to help us write compelling recaps of each episode. Get full access to Superpowers for Good at www.superpowers4good.com/subscribe

➡️ This was recorded in early 2021.Sucharit Bhakdi believes that fear and vaccines, not a virus, makes people sick, and says to always reject the propaganda being sold to us. He is a very distinguished retired Thai-German microbiologist, formerly a professor at the University of Mainz, where he led the Institute of Medical Microbiology and Hygiene until 2012.Writing this years later, I can't remember clearly, but from what I can recall, Sucharit was one of the first 'mainstream' scientists to call BS on the whole thing, declaring it a 'fake' crisis.

In this episode Martin talks to Dr Andy Borman, (Acting Head and Consultant Clinical Scientist, UKHSA National UK Mycology Reference Lab. also Hon Professor of Medical Mycology, MRC CMM, University of Exeter), Dr Colin Brown (Deputy Director of Emerging and Epidemic Infections at UK Health Security Agency; Honorary Consultant in Infectious Diseases & Medical Microbiology at Royal Free London NHS Foundation Trust) and Dr Mariyam Mirfenderesky (Consultant in Medical Microbiology and Infectious Diseases North Middlesex and RF (AMS Lead) and UKHSA on HCAI). The UK Health Security Agency (UKHSA) is the national organisation in the United Kingdom responsible for protecting public health by preventing, detecting, and responding to infectious diseases and other health threats. We chat about how Candidozyma auris (formerly known as Candida auris) is identified in the lab, why it matters clinically, and what it means for infection prevention and control teams. From early lab detection to real-world frontline challenges, we discuss the key issues around this emerging pathogen — and what we need to do next. UK C. auris guidance can be found here: https://www.gov.uk/government/publications/candida-auris-laboratory-investigation-management-and-infection-prevention-and-control

In this episode Martin talks to Dr Andy Borman, (Acting Head and Consultant Clinical Scientist, UKHSA National UK Mycology Reference Lab. also Hon Professor of Medical Mycology, MRC CMM, University of Exeter), Dr Colin Brown (Deputy Director of Emerging and Epidemic Infections at UK Health Security Agency; Honorary Consultant in Infectious Diseases & Medical Microbiology at Royal Free London NHS Foundation Trust) and Dr Mariyam Mirfenderesky (Consultant in Medical Microbiology and Infectious Diseases North Middlesex and RF (AMS Lead) and UKHSA on HCAI). The UK Health Security Agency (UKHSA) is the national organisation in the United Kingdom responsible for protecting public health by preventing, detecting, and responding to infectious diseases and other health threats. We chat about how Candidozyma auris (formerly known as Candida auris) is identified in the lab, why it matters clinically, and what it means for infection prevention and control teams. From early lab detection to real-world frontline challenges, we discuss the key issues around this emerging pathogen — and what we need to do next. UK C. auris guidance can be found here: https://www.gov.uk/government/publications/candida-auris-laboratory-investigation-management-and-infection-prevention-and-control

 For this episode of Microbe Talk Clare is joined by Dr Sanjay Patel, a paediatric infectious disease and immunology consultant at Southampton Children's Hospital and the National Clinical Advisor for Paediatric Antimicrobial Stewardship at NHS England. Clare and Sanjay discuss paediatric AMR, why it's often overlooked and how Sanjay and his colleagues from clinical, research and policy backgrounds are taking action.  If you'd like to learn more about research into antimicrobial resistance in neonates, take a look at this paper in Journal of Medical Microbiology.You can find details of how to get involved with Knocking Out AMR here.The resources and initiatives Sanjay mentioned are below:  National empirical antimicrobial guidelines The common infection clinical pathways, the IV to oral switch decision aid The common infection paediatric pathways Music: Inspiring Science Technology - Comma Media from Pixabay

Avec Dre Fatima Kakkar, pédiatre-infectiologue, et Marie-Élaine Métras, pharmacienne, nous allons:  Rappeler les notions de base sur le VIH et souligner des enjeux sociaux importants Discuter des différents schémas thérapeutiques d'antirétroviraux pour prévenir la transmission mère-enfant du VIH Distinguer les recommandations sur l'allaitement chez les mères vivant avec le VIH et les traitements préventifs recommandés chez le nourrisson Références:Panel on Treatment of HIV During Pregnancy and Prevention of Perinatal Transmission. Recommendations for the Use of Antiretroviral Drugs During Pregnancy and Interventions to Reduce Perinatal HIV Transmission in the United States: Management of Infants Born to People With HIV Infection. Department of Health and Human Services. Janvier 2023. Panel on Antiretroviral Therapy and Medical Management of Children Living with HIV. Guidelines for the Use of Antiretroviral Agents in Pediatric HIV Infection. Department of Health and Human Services. Janvier 2024. Khan S, Tsang KK, Brophy J, Kakkar F, Kennedy VL, Boucoiran I, Yudin MH, Money D, Read S, Bitnun A; Canadian Pediatric & Perinatal HIV/AIDS Research Group, the Infectious Disease Committee of the Society of Obstetricians and Gynaecologists of Canada, the Canadian HIV and Viral Hepatitis Pharmacists Network, and the Association of Medical Microbiology and Infectious Disease Canada. Canadian Pediatric & Perinatal HIV/AIDS Research Group consensus recommendations for infant feeding in the HIV context. J Assoc Med Microbiol Infect Dis Can. 2023 Mar 1;8(1):7-17. Gouvernement du Québec. La thérapie antirétrovirale pour les adultes infectés par le VIH. Décembre 2022. Sections 9.4.1, 9.5 et 9.6.Nesheim SR, FitzHarris LF, Mahle Gray K, Lampe MA. Epidemiology of Perinatal HIV Transmission in the United States in the Era of Its Elimination. Pediatr Infect Dis J. 2019 Jun;38(6):611-616. Programme commun des Nations Unies sur le VIH/sida (ONUSIDA). La voie pour mettre fin au sida : Rapport mondial actualisé sur le sida. 2023.Programme de lait. CHU Sainte-Justine. 2022.-------------------------------------------Captation et montage: Philippe Lacroix, spécialiste en audiovisuel Musique: Samuel Ross  Logo: Équipe des communications et du graphisme du CHU Sainte-Justine Montage pour les réseaux sociaux: Pierre-Antoine Bernard Idée originale, réalisation et animation: Émilie Roy-St-Pierre Collègues, ami(e)s et famille, merci pour votre précieux soutien. En collaboration avec le CHU Sainte-Justine, membre du Réseau mère-enfant de la francophonie.  © mgparkilo 2024 Merci pour l'écoute! Allez mettre une réaction sur vos épisodes préférés, partagez la bonne nouvelle sur Facebook/Instagram et abonnez-vous pour ne rien manquer

Clare is back with another episode of Microbe Talk and this time she's investigating the topic of Microbial Forensics with Dr Tim Inglis from the University of Western Australia. Tim is the Editor-in-Chief of the Society's Journal of Medical Microbiology where he published his review on the topic: ‘A systematic approach to microbial forensics'. You can read a full transcript of this podcast on our website.Music by Denys Kyshcuk from Pixabay.

What if we could actually identify and even correct significant autism risk factors in utero, before a baby is born? This is the promise of the game-changing research of Dr. Janine LaSalle, epigeneticist extraordinaire from UC Davis. With autism rates continuing to increase at alarming rates (the latest data from the CDC, released in 2023, is 1 in 36 children in the US, an increase from the prior 1 in 44), new ways to prevent and treat this condition are of utmost importance. Dr. LaSalle is on a mission to change that, by investigating something you probably haven't heard much about yet - the placental methylome. Methylation signatures in the maternal placenta are yielding information both for predicting autism in children and for intervention targets to prevent the development of the disease. It's just incredibly exciting. In our conversation, you'll also learn how placental methylation behaves differently to DNA methylation in other tissues, and how the placental methylome may also help us better understand cancer as well as mechanisms that restore more youthful epigenetic patterns. Hold onto your hats folks - yes this is deep science, but it's also actionable even now. You'll hear how methylation support specifically in the early pregnancy window is key and how it's also protective against insults from environmental toxicants. You're in for a treat with this fascinating conversation that has far-reaching implications for you and your patients. ~DrKF Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources. Guest Information Janine LaSalle, Ph.D. Professor, Medical Microbiology and Immunology, School of Medicine University of California, Davis jmlasalle@ucdavis.edu The LaSalle Lab at University of California, Davis Thank you to our sponsors Diamond Rupa Health: https://tinyurl.com/4anbz7b3 Biotics Research: https://www.bioticsresearch.com/ Integrative Therapeutics: https://tinyurl.com/4emwj48z Gold TimeLine Nutrition: https://tinyurl.com/bdzx2xms OneSkin: https://tinyurl.com/ycxtw4zt Try OneSkin for yourself with coupon code DRKARA15 to receive 15% off your first purchase. Midroll Practice Better: https://tinyurl.com/28mmab99 Start your free trial and save 20% for 4 months on any paid plan with code KF20 Show Notes Perinatal Origins of Disparities Center: https://pod.ucdavis.edu/ Environmental Health Sciences Center: https://environmentalhealth.ucdavis.edu/ MIND Institute: https://health.ucdavis.edu/mindinstitute/ Article: Too Much Folate in Pregnant Women Increases Risk for Autism, Study Suggests: https://tinyurl.com/bdf9ez6k The human placental methylome: https://tinyurl.com/7zz8dz55 Markers of Autism Risk in Babies (MARBLES): https://tinyurl.com/49phe22r

We're back with another game of 'Would you rather?' Where we pose a scenario, and our guests give us their views. This episode really challenges the basis of some of the beliefs and practices regarding antimicrobials. Some of the questions are so tricky, who knows if there even is a correct answer. What we do know is... it depends.About our Guest: Prof. Andrew Whitelaw worked as a consultant pathologist in clinical microbiology at Groote Schuur Hospital from 2003 – 2012. In December 2012 took up the post of Head of Department of Medical Microbiology at the University of Stellenbosch / Tygerberg Hospital. His early research revolved around molecular characterization of ESBLs in members of the Enterobacteriaceae, and he has been involved in a number of studies and activities related to antimicrobial resistance (AMR) and infection control over the last decade, both for community as well as hospital acquired pathogens. Most relevant among these would be his involvement in the South African Antibiotic Stewardship Programme (SAASP), The Infection Control Society of Southern Africa, and the SA Ministerial Advisory Committee on AMR. Ongoing research interests focus on antimicrobial resistance in Enterobacteriaceae and Staphylococcus aureus, including molecular epidemiology and mechanisms of resistance as well as clinical impact and control of AMR. He is also involved in studies describing the human microbiota and in particular the effect of antimicrobials on the microbiota.Resources from this episode:SASCM C. difficile infection guidelinesWE'D LOVE YOUR FEEDBACK ON THIS EPISODE – Visit the Microbe Mail website to sign up for updates Follow on:Instagram: Microbe_MailX/Twitter: @microbemailFacebook: MicrobeMailTiktok: @microbe.mailWatch this episode on our new YouTube channel: Microbe MailE-mail us: mail.microbe@gmail.comDon't forget to also have a listen to these featured episodes:Episode 43: Communicating antimicrobial therapy to patientsEpisode 38: Would you rather?: The mycology versionEpisode 35: Would you rather?: The virology versionEpisode 33: Would you rather?:The Bacterial version

Today's guests: Molly McKew, Lead writer at GreatPower.us / Writer & lecturer on Russian influence & information warfare Joanna Baron – Executive Director – Canadian Constitution Foundation James Fell -Columnist / Author / “The Sweary Historian” (Featured Speaker - Western Canadian Reason Conference May 3-5) Andrew Grantham, Executive Director and Senior Economist for Economics and Capital Markets for CIBC Dr. Jason Kindrachuk, Associate Professor & Canada Research Chair in the Department of Medical Microbiology & Infectious Diseases at the University of Manitoba Learn more about your ad choices. Visit megaphone.fm/adchoices

In this week's episode, both of our storytellers share tales that illuminate the transformative power of returning to their roots. Part 1: Gregor Posadas joins the army to pursue his dreams of becoming an engineer and fulfill his father's wish of “fixing” their home country of the Philippines. Part 2: After losing his father as a young child, Nanduh Balakrishnan feels compelled to use his school savings to buy a life saving drug for a patient at the hospital he's working at. Gregor Posadas is a Civil Engineering student and Undergraduate Research Assistant at Boise State University. He is currently set to graduate from his undergraduate studies by December 2023. Born and raised in the Philippines, he grew up with a strong interest and deep appreciation for science and engineering, thanks largely in part to the influence of his late father Dr. Roger Posadas - a former relativity physicist, professor, and chancellor of the University of the Philippines. Gregor is committed to learning about new technologies in water/wastewater treatment, sustainable infrastructure, and water resource systems in developing countries. He specializes in data analysis and environmental engineering. He is set to begin his masters studies at Boise State University in the Spring semester of 2024, immediately following his undergraduate graduation.Outside of his studies, Gregor also currently serves as a Combat Engineer in the United States Army Reserves. He enlisted in 2019, just eight months after moving from the Philippines to Idaho. Gregor also serves as a Graphic Designer and Marketing Delegate for the Boise State Martin Luther King Living Legacy Committee - Boise State's student agency in charge of organizing the annual MLK Day March in Boise, Idaho.With a unique upbringing and an diverse set of experiences, Gregor is an engineering student with many interesting stories to tell. Nandhu Balakrishnan works for Georgia Public Health Laboratory as Director of Microbiology. His job involves public health and community service. He was born and raised from Southern India. He completed my Master's and PhD in Medical Microbiology from India. In 2008, he migrated to United States and worked as post-doctoral fellow before he landed into a real stable job. His passion towards laboratory science has stemmed from his childhood and it has been a roller coaster throughout the years to climb to the pinnacle of success. He loves cooking with authentic spices and enjoys feeding people. Learn more about your ad choices. Visit podcastchoices.com/adchoices

Optimizing your gut microbiome is arguably one of the most important things you can do for your health as it plays so many integral roles in almost every body system. This is why, in this episode of Biohacking Superhuman Performance, I chat with Chidozie Ojobor, Ph.D.  about the importance of the microbiome's influence on human health, particularly on the gut-brain connection and mental well-being.   He discusses the role of butyrate, leaky gut/brain, probiotics, and the importance of diet diversity in promoting a healthy microbiome. The conversation also covers the impact of modern lifestyle, antibiotics, and colon cleansing on gut health, and how to get accessible gut microbiome testing - in particular, the testing done by Vitract.    Chidozie Ojobor Ph.D. is a Molecular Biologist with over 12 years of experience in Medical Microbiology research, and the co-founder and Chief Science Officer of Vitract. In his early research years, he worked on human rotaviruses that cause severe gastroenteritis in children.   Afterward, he proceeded to earn his Ph.D. in Molecular Genetics from the University of Toronto, Canada. During his doctoral training, he developed through genetic engineering, novel therapeutic entities that target disease-causing bacteria such as the ones found in complex biological ecosystems as the gut microbiome. These tools he developed worked with high specificity and precision, making them the ideal candidates for targeted therapy. Dr. Ojobor's works in the fields he worked in have been well-cited by numerous scientists across the globe. Thank you to our sponsors for making this episode possible: CAROL Bike: Use code NAT for $100 off at www.carolbike.com Sensate: Use code NAT at www.getsensate.com/Nat  BiOptimizers: For Sleep Breakthrough use code bionat at checkout to save on your order and receive free gifts at www.bioptimizers.com/bionat    Find more from Chidozie Ojobor: Website: https://vitract.com/  Instagram: @vitractofficial Use Code NAT10 at vitract.com to save on a Vitract test   Find more from Nathalie: YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ Join Nat's Membership Community: https://www.natniddam.com/bsp-community Sign up for Nats Newsletter: https://landing.mailerlite.com/webforms/landing/i7d5m0 Instagram: https://www.instagram.com/nathalieniddam/ Website: NatNiddam.com Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance   What We Discuss:  00:00 Introduction and Background 00:52 Advancements in Microbiome Research 04:39 The Significance of the Microbiome 05:09 The Gut-Brain Connection 06:22 Microbiome and Mental Health 08:11 The Role of Butyrate in Gut Health 09:06 Butyrate Supplementation 14:05 Leaky Gut and Leaky Brain 21:11 Foods that Promote Butyrate Production 23:06 Probiotics and Microbiome Diversity 29:23 The Role of Geography and Lifestyle in Gut Microbiome 30:03 The Importance of Gut Diversity for Health 31:35 Impact of Modern Lifestyle on Gut Diversity 32:30 Adaptation of the Gut Microbiome to the Environment 34:03 The Influence of Environmental Factors on the Gut Microbiome 35:14 The Complexity of Achieving the 'Perfect' Gut Microbiome 36:03 The Functional Level of the Gut Microbiome 37:19 The Impact of Antibiotics on the Gut Microbiome 39:10 The Resilience of the Gut Microbiome 40:33 The Use of Probiotics During Antibiotic Treatment 45:36 The Detrimental Effects of Prolonged Antibiotic Usage 48:19 The Link Between Food Poisoning and Gut Health 49:17 The Detrimental Effects of Colon Cleansing 50:45 The Controversy Surrounding Enemas and Colonics 53:19 The Impact of Chronic Stress and Antibiotic Overuse on the Microbiome 54:04 The Transition to Gut Microbiome Testing 55:28 The Need for Affordable and Comprehensive Gut Microbiome Tests 56:21 Understanding the Vytract Gut Microbiome Test 58:09 Transparency and Personalization in Gut Microbiome Testing 59:42 Short-Term Variability and Clinical Utility of Microbiome Testing 01:03:41 The Importance of Accepting Differences in Dietary Approaches 01:09:47 The Focus of Vytract's Gut Microbiome Test 01:11:30 Where to Find More Information and Order a Vitract Test Key Takeaways: Reduced gut diversity, often seen in individuals living in civilized nations, can have negative health implications. Antibiotics can disrupt the gut microbiome, and the use of probiotics during and after antibiotic treatment may help restore balance. Prolonged antibiotic usage can have long-term consequences for gut health, including increased risk of certain conditions. Colon cleansing and enemas may have detrimental effects on the gut microbiome and should be approached with caution. Chronic stress and antibiotic overuse can disrupt the microbiome. Gut microbiome testing provides valuable insights into gut health. Affordable and comprehensive tests are needed to improve access to microbiome testing. Short-term changes in the microbiome can have clinical utility.  

An insightful discussion on Program Management 8X within Army Medicine. Join us as our distinguished guest, Microbiologist 71A MAJ Amanda Roth, delves into the intricacies of her role and shares her unparalleled expertise in the field. MAJ Amanda L. Roth was born in Seoul, South Korea and grew up in the suburbs outside Minneapolis, Minnesota. She earned her Associates of Applied Science degree in Medical Laboratory Technology through the Community College of the Air Force as an enlisted airman and a Bachelor of Science degree in Clinical Laboratory Science on the Montgomery GI Bill as a civilian in 2007. MAJ Roth graduated from Creighton University in 2012 where she studied multidrug-resistant bacteria and received a PhD in Medical Microbiology and Immunology in the laboratory of Dr. Nancy Hanson.Following her commission into the U.S. Army in 2013, MAJ Roth served in multiple positions under the Bacterial Diseases Branch at the Walter Reed Army Institute of Research in Silver Spring, Maryland. In 2017, she was the first scientist accepted into the Army Medical Department's Program Management Acquisitions Internship Program at the US Army Medical Materiel Development Activity at Fort Detrick, Maryland. After completing this internship, she deployed for 11 months to U.S. Central Command as the Theater Microbiologist under 1st Medical Brigade in support of Operations Spartan Shield, Inherent Resolve, and Freedom's Sentinel. From 2019-2021, MAJ Roth was the Director of the Infectious Disease Program at the US Army Medical Research Directorate—Africa, based in Kisumu, Kenya, where she oversaw the execution of over $25M of research, development, and surveillance activities of infectious diseases of military relevance alongside Eastern African. In addition to her graduate degree, MAJ Roth is a certified Medical Laboratory Scientist (American Society of Clinical Pathologists). She also holds Defense Acquisition Workforce Improvement Act Practitioner certifications in Program Management and Engineering and Technology Management and is a member of the Army Acquisition Corps. MAJ Roth volunteers extensively in both the 71A and 8X Medical Acquisition communities and is currently the Graduate Education Manager for the former and the Deputy 8X Consultant for ETM to the Office of the Surgeon General for the latter. Currently MAJ Roth is the Assistant Product Manager for MC4, the Army's Program Management Office for Operational Health Information Technology (OHIT) solutions. She is currently responsible for the orderly and deliberate closure of MC4 as well as the development of the new acquisition programming for OHIT modernization, Operational Medicine Information Systems – Army (OMIS-A).Army Force Management 101: https://youtu.be/4mUg4YvZaoQ?si=YdHA5usg8Qojz5t_Defense Acquisition University credentials: https://icatalog.dau.edu/onlinecatalog/CareerLvl.aspxAMEDD Lessons learned: https://medcoe.army.mil/lessons-learned Amanda's research : https://academic.oup.com/milmed/article/180/5/591/4161841Disclaimer: The views expressed in this podcast are the guests and host's alone and do not reflect the official position of the Medical Service Corps, the Department of Defense, or the US Government. All information discussed is unclassified approved for public release and found on open cleared sources.For more episodes listen on Apple Podcasts, Spotify, or YouTube @ Be All You Can Be MSC For more information, suggestions, or questions please contact: beallyoucanbemsc@gmail.com

https://www.gofundme.com/f/paul-bolmers-stroke?fbclid=PAAaahgWIFOEoVTvRZ7T8opP6gRRbzwG8dv2OrP-23CrTnIWoqEDrG45_doUk_aem_AVYp7RMh4SVGsA1Cn_X6SpjPvrjsgSEn-MMJJecLA8JOf_bcMIoi2EU59mCKDZVzqO4 Dr. Mohamed ElSalhy obtained his Bachelor of Dental Medicine (B.D.M.) degree from Kuwait University in 2007. He then completed a Master of Science in Medical Microbiology at the Faculty of Medicine, Kuwait University in 2011. Dr. ElSalhy earned his first Ph.D. in Odontology from the University of Turku, Finland in 2015, followed by a second Ph.D. in Medical Sciences - Dentistry from University of Alberta, Canada in 2018. Dr. ElSalhy completed his Dental Public Health residency and Master of Public Health degree at Case Western Reserve University in Cleveland, Ohio in June 2018. He is a Member of the Faculty of Dentistry of the Royal College of Surgeons in Ireland and Fellow of the Royal College of Dentists of Canada. Dr. ElSalhy's research interests include accuracy of caries detection and diagnosis, innovative methods for caries prevention and management, and community-based preventive interventions. Discussed this week: Oral health risks associated with cannabis consumption, smoking's impact on your health, Dr Muhammad alsahlhe, the University of New England's oral health center, student dentists, shave free dental practices, good health hygiene practices, irreversible damage, Candida, fungal infections in the mouth, dirty bong water, karyogenic snacks, the dangers of dry mouth, entertaining yourself during toothbrush time, and more! --- Send in a voice message: https://podcasters.spotify.com/pod/show/potluckypodcast/message Support this podcast: https://podcasters.spotify.com/pod/show/potluckypodcast/support

In this episode of Microbe Talk Clare is joined by Rick Mumford, Deputy Chief Scientific Advisor & Deputy Director of Science Evidence & Research at the UK Food Standards Agency (FSA). They chat about research and surveillance of foodborne antimicrobial resistance (AMR), delivering on the 5-year National Action Plan and look to the future of foodborne AMR. If you'd like to read Rick's paper, ‘Foodborne antimicrobial resistance (AMR) research and surveillance in the UK: priorities identified through the Food Standards Agency's AMR programme review (2023)' published in Journal of Medical Microbiology, the Society's interdisciplinary journal for medical, veterinary and dental microbiology, you can do so here. If you'd like to keep up to date with the FSA's science news, publications and research partnership opportunities you can sign up to their newsletter here.If you'd like to get involved in tackling AMR you can find out more information on our Knocking out AMR project and register your interest on our website.Music by Yrii Semchyshyn from PixabayA full transcript is available on our website.

Dr. Adrian Brink is a Professor in the Division of Medical Microbiology at the University of Cape Town's National Health Laboratory Services and he joins John to consider the potential of a new antibiotic class that offers hope for addressing critical drug-resistant infections.See omnystudio.com/listener for privacy information.

Artificial intelligence has the power to transform the way researchers study bacteria and develop new treatments – and we're already seeing the benefits in healthcare. In part three, host Jeremiah Owyang and expert guests shed light on how AI expedites and enhances analyses, revolutionizing the search for new antibiotics. The benefits of AI extend to analyzing bacterial DNA, uncovering vulnerabilities, and potentially predicting bacterial evolution. This innovative technology aids scientists in pinpointing the most promising antibiotic candidates from a sea of possibilities and helps to streamline drug development.Featured Guests:Adrian Egli, Director, Institute of Medical Microbiology, University of ZurichLei Zhang, Executive Director of Medicinal Chemistry, Pfizer Medicine DesignMarinka Zitnik, Assistant Professor, Department of Biomedical Informatics, Harvard Medical School; Co-founder, Therapeutics Data Commons Season 3 of Science Will Win is created by Pfizer and hosted by Jeremiah Owyang, entrepreneur, investor, and tech industry analyst. It's produced by Wonder Media Network.

Artificial intelligence could be an essential tool in the fight against antibiotic resistant bacteria – and data is a key part of developing that tool. In part two of this four-part series, expert guests break down the mechanics behind artificial intelligence and machine learning. As host Jeremiah Owyang traces the evolution of these tools in healthcare, he highlights the crucial role of data for understanding the problem of antibiotic resistance. Featured Guests:Adrian Egli, Director, Institute of Medical Microbiology, University of ZurichRanjit Kumble, Vice President of Enterprise Data Science and Advanced Analytics, PfizerMarinka Zitnik, Assistant Professor, Department of Biomedical Informatics, Harvard Medical School; Co-founder, Therapeutics Data Commons Season 3 of Science Will Win is created by Pfizer and hosted by Jeremiah Owyang, entrepreneur, investor, and tech industry analyst. It's produced by Wonder Media Network.

Medicine's struggle with antibiotic resistant bacteria is reaching a crisis point. In part one of this four-part series, host Jeremiah Owyang and expert guests delve into the world of antibiotics, exploring their history, the rise of antibiotic resistance, and the story of a patient whose life was forever changed by antibiotic-resistant bacteria. They break down the critical issues at stake and discuss the multifaceted solutions needed to combat this pressing crisis – including artificial intelligence.Featured Guests:Adrian Egli, Director, Institute of Medical Microbiology, University of ZurichJay Purdy, Vice President and Therapeutic Area Lead, Global Medical Affairs, Pfizer Antibacterial and Antifungal ProgramsMary Lynne Van Poelgeest-Pomfret, President, World Federation of Incontinence and Pelvic Problems Season 3 of Science Will Win is created by Pfizer and hosted by Jeremiah Owyang, entrepreneur, investor, and tech industry analyst. It's produced by Wonder Media Network.

For Episode 3 of The Eastman Dental Podcast, Simone Ruzario discusses her career journey from studying Chemistry to Dental Therapy. After completing her degree in Medical Microbiology, Simone completed her dental training at Barts. Since then, she has completed her post graduate training and gained a Master of Public Health - MPH from The University of Manchester. Simone shares her experience working in the voluntary sector and her inspirational outreach work across the globe.

Vanessa Sperandio is a professor at the UT Southwestern Medical Center in both the departments of microbiology and biochemistry. She joined the University of Wisconsin School of Medicine and Public Health as the chair of the Department of Medical Microbiology and Immunology in spring 2022. Sperandio's research focuses on the signaling mechanisms between mammalian hosts, their beneficial microbiota, and bacterial pathogens. Sperandio was a 1997 fellow of the Pew Charitable Trust and was elected to the American Academy of Microbiology in 2013.[3] She is also a Kavli Frontiers of Science Fellow by the National Academy of Sciences and selected as a Burroughs Wellcome Fund Investigator in the Pathogenesis of Infectious Diseases.   In this episode: Personal/Professional Journey Our relationship with Bacteria Neurotransmitters Microbiome Imbalance Nutritional Therapy Interventions Processed Foods and our gut How to eat for our gut microbiome Supplements and Probiotics Psychedelics, Microbiome, and Addiction   The content of our show is educational only. It does not supplement or supersede your healthcare provider's professional relationship and direction. Always seek the advice of your physician or other qualified mental health providers with any questions you may have regarding a medical condition, substance use disorder, or mental health concern.  

Inflammatory bowel disease (IBD) — an umbrella term for conditions including Crohn's disease and ulcerative colitis — affects millions of people worldwide, sometimes severely affecting their quality of life. How is the gut microbiome of a person with IBD different, and can we use diet to change it and help with disease management? To answer these and other questions, we are in conversation with Dr. Marcel de Zoete, associate professor in the Department of Medical Microbiology at UMC Utrecht in The Netherlands, who has studied the gut microbiome in IBD. Also joining us is Zosia Krajewska, who lives with IBD after receiving a diagnosis at age 14.

When you hear the story of how syphilis research was carried out in the United States in the 20th century, you'll probably start to understand why there is a history of mistrust of the medical establishment, especially among the African American community.  This episode details one of the bleakest and most shameful chapters in U.S. medical history, a time when ethics were cast aside at the expense of minority communities.  We'll talk about the Tuskegee Syphilis Study (aka Tuskegee Experiment) as well as the Guatemala syphilis experiments that preceded them.  Sources:For symptom confirmation: https://www.uptodate.com/contents/syphilis-epidemiology-pathophysiology-and-clinical-manifestations-in-patients-without-hiv?search=syphilis&source=search_result&selectedTitle=3~150&usage_type=default&display_rank=3#H10 UpToDate (paywall)Emily Blunt gets Syphilis: https://en.wikipedia.org/wiki/The_English_(TV_series)Medical Microbiology, Chapter 36: https://www.ncbi.nlm.nih.gov/books/NBK7716/ Wikipedia Syphilis: https://en.wikipedia.org/wiki/SyphilisLong Article on Syphilis Origin: https://asm.org/Articles/2019/June/Revisiting-the-Great-Imitator,-Part-I-The-Origin-aRepublication of the AP study about Tuskeegee: https://apnews.com/article/business-science-health-race-and-ethnicity-syphilis-e9dd07eaa4e74052878a68132cd3803aBioethics statement on Guatamala Studies: https://bioethicsarchive.georgetown.edu/pcsbi/sites/default/files/Ethically%20Impossible%20(with%20linked%20historical%20documents)%202.7.13.pdfWikipedia on Guatemala Studies: Sponsor: Artery InkUse promo code LISTENTOPHP at Artery Ink's website to save 10%* on your order of $35 or more and show support for our show as well as for a homegrown, wonderful local company. Artery Ink specializes in apparel and decor inspired by anatomy and the human body. Whether you're in the field of healthcare or not, Artery Ink has something that will definitely appeal to you so go and check them out! (*Discount code does not apply to subscription boxes)Submissions for Mike's Trivia Challenge Segment:-We invite our audience to submit medical history trivia questions (with or without a supporting article) to see if Mike happens to know the answer off the top of his head.-If Mike is wrong we'll award you your very own medical eponym so that you can join us in becoming a part of medical history.-Submit through our website, social media DMs, or via e-mail: poorhistorianspod@gmail.comPodcast Links:-Linktree (reviews/ratings/social media links): linktr.ee/poorhistorianspod-Merch Site: https://www.teepublic.com/user/poor-historians-pod...

GUEST 1 OVERVIEW: Di McMillan is a women's rights campaigner and former candidate for the Freedom Alliance Party in the UK. GUEST 2 OVERVIEW: Professor Sucharit Bhakdi MD is a retired Professor Emeritus of Medical Microbiology and Immunology, Former Chair, Institute of Medical Microbiology and Hygiene, Johannes Gutenberg University of Mainz. Professor Bhakdi is one the most important scientific critics of the reaction of governments to the COVID 19 disease and the mRNA vaccinations developed against it. Together with his wife, a professor for biochemistry, he wrote two bestselling book about the topic, one headed the German book charts for weeks. He faced fierce criticism for his concern, becoming the target of media campaigns and now faces a trial for antisemitism in Germany, which is considered as government induced smear attack to damage his reputation and silence his scientific criticism.

This year the Microbiology Society is hosting FIS (the Federation of Infection Societies (FIS) conference) in partnership with HIS and BIA. FIS is all about fostering cross-disciplinary collaboration, so in this episode of Microbe Talk Clare speaks to Professor Elaine Coultman-Green, a microbiologist whose work spans clinical, lab, and patient-facing roles about the importance of collaboration across microbiology disciplines. If you're inspired by this conversation and want more information regarding FIS, you can find the details and information on how to register here.To find out more about the Society's Journal of Medical Microbiology which encourages the publication of cross-disciplinary research, please visit our website for more information about the scope and submission guidelines. To follow Elaine, she is @girlymicro. Music by Dmitrii Kolesnikova from PixabayYou can also read the transcript of the podcast here.

In this episode of the Smarter Not Harder Podcast, our guest Dr. Neil Grunberg joins our host Boomer Anderson to give one-cent solutions to life's $64,000 questions that include: What is a good leader? What makes good followers? What are attributes that you can acquire as a good follower? What is the optimal model for leadership?    Dr. Neil Grunberg is a professor of Military and emergency medicine, medical and clinical psychology, and neuroscience in the Uniform Services University School of Medicine. He's a professor in the Graduate School of Nursing, Director of Research and Development, Director of Leadership and Education Development Program and The Director of Faculty for MEM. He's a Chair of Faculty Mentoring and Development for the ANE. He's a Medical and Social Psychologist who has been on faculties with the USU since 1979.   Dr. Neil Grunberg earned his baccalaureate degrees in Medical Microbiology and Psychology from Stanford University. He earned his master of the Arts and Master's Philosophy and PhD degrees from Physiological and Social Psychology from Columbia University. He also serves as the co-founder of the International Leaders Association Healthcare Leadership Community and a member of the Working Group for the World Leadership Network. He was also selected as the Presidential Leadership Scholar and had the opportunity to work with many former members of cabinets of Presidents Johnson, Bush, Clinton and Bush II.  What we discuss: (0:08:17) - Learning Leadership and Developing Models (0:24:09) - Leadership and Followership (0:34:03) - Training Emotional Intelligence for Effective Leadership (0:52:53) - Understanding Different Types of Followership (1:05:46) - Improving Communication Skills (1:14:34) - Trust and Feedback in Organizations Importance (1:20:53) - Leadership and Team Collaboration in Healthcare   Find more from Smarter Not Harder: Website: https://troscriptions.com/blogs/podcast | https://homehope.org Instagram: @troscriptions | @homehopeorg   Find out more from Dr. Neil Grunberg Website: https://www.researchgate.net/profile/Neil-Grunberg   Get 10% Off Your Purchase of the Metabolomics Module by using PODCAST10 at https://www.homehope.org   Get 10% Off your Troscriptions purchase by using POD10 at https://www.troscriptions.com   Get daily content from the hosts of Smarter Not Harder by following @troscriptions on Instagram.  

Medical Devices that are reusable should be cleaned. But the user is not a professional of your product so he needs to receive some instruction on how to clean it. In this episode of the podcast we will explain to you what is cleaning validation and also talk about microbiology, electrical device cleaning, Notified Body issues… So let's listen to Enrico Allegra from TestLabs who will share with us his experience. Who is Enrico Allegra? Enrico has over 10 years of experience in regulatory microbiology combining environmental safety with clinical settings as a study director. He graduated with a Bachelor of Science degree in Immunology with Medical Microbiology followed by a master's degree in Clinical Microbiology from Queen Mary University of London in 2013. During his previous role, he worked extensively in method transfer and development. His work spanned from environmental microbiology to clinical settings. He worked on clinical trials to assess the validity of vaccination against Group B Streptococci in pregnant women. He was strongly involved in the assessment of the safety of agrochemical products such as biocides as well as being the lead scientist for the assessment of antimicrobial susceptibility testing of pre and probiotic products. During his time working in safety assessment, he collaborated on a CRACK-IT sponsored research under the NC3Rs as the lead scientist. The research focused on evaluating the discrimination of toxic and non-toxic chemicals using wax moth larvae Galleria mellonella as model to help reduce, replace, and refine the use of animal models. The research was published for Chemosphere (Elsevier) in May 2018. During the height of the pandemic, he worked on the development of antiviral assays against Coronavirus as well as being part of clinical trial of bacteriophage technology to help fighting secondary infection of cystic fibrosis patients. He is a certified biosafety officer and operates as the Head of Laboratory at Test Labs, a Medical Device testing laboratory. Enrico massively helped developing the facility from an empty canvas to a fully operational ISO 17025:2017 accredited laboratory, in less than 11 months. Leading the microbiology, chemistry and material sciences teams in performing Medical Device testing, he provides expert knowledge combining the experience in method validation and new method development to help customer with reliable and fully validated reports. Who is Monir El Azzouzi? Monir El Azzouzi is the founder and CEO of Easy Medical Device a Consulting firm that is supporting Medical Device manufacturers for any Quality and Regulatory affairs activities all over the world. Monir can help you to create your Quality Management System, Technical Documentation or he can also take care of your Clinical Evaluation, Clinical Investigation through his team or partners. Easy Medical Device can also become your Authorized Representative and Independent Importer Service provider for EU, UK and Switzerland. Monir has around 16 years of experience within the Medical Device industry working for small businesses and also big corporate companies. He has now supported around 100 clients to remain compliant on the market. His passion to the Medical Device filed pushed him to create educative contents like, blog, podcast, YouTube videos, LinkedIn Lives where he invites guests who are sharing educative information to his audience. Visit easymedicaldevice.com to know more. Links from the Video ■Enrico Allegra LinkedIn: https://www.linkedin.com/in/enrico-allegra-b97751164 ■TestLabs LinkedIn Page: https://www.linkedin.com/company/testlabsuk/ ■TestLabs webpage: https://testlabsuk.com/ Social Media to follow ■ Monir El Azzouzi Linkedin: https://linkedin.com/in/melazzouzi ■ Twitter: https://twitter.com/elazzouzim ■ Pinterest: https://www.pinterest.com/easymedicaldevice ■ Instagram: https://www.instagram.com/easymedicaldevice

On this week's episode, Rich Thayer and Mickey Urdea are exploring metagenomics with Dr. Rick Nolte, an engaging expert on the subject. Dr. Nolte helps to define what metagenomics is, its diagnostic uses, its advantages, and where the field is going. This is a delightfully in-depth interview about a complicated but important topic that is very much worth your time; please enjoy. Frederick (Rick) S. Nolte, PhD, is currently a Senior Director/Medical Advisor at Karius, the microbial cell free DNA company, and Professor Emeritus of the Department of Pathology and Laboratory Medicine at the Medical University of South Carolina. He served as Vice-Chair for Laboratory Medicine/Medical Director of Clinical Laboratories and Molecular Pathology. He is a Diplomate of the American Board of Medical Microbiology and a Fellow of the American Academy of Microbiology. Dr. Nolte completed his B.S. degree in Biology at the University of Cincinnati, and his Ph.D. in Medical Microbiology at the Ohio State University. Dr. Nolte completed a postdoctoral fellowship in Public Health and Medical Laboratory Microbiology at the University of Rochester. Prior to coming to MUSC in 2007, he spent 18 years at Emory University School of Medicine where he was a Professor of Pathology and Laboratory Medicine and Director of the Clinical Microbiology, Molecular Diagnostic, and Serology Laboratories at Emory Medical Laboratories. He is active in and held positions of responsibility in the American Society for Microbiology, Association for Molecular Pathology, Clinical and Laboratory Standards Institute, Infectious Diseases Society of America, American Society for Clinical Pathology, College of American Pathology and American Association for Clinical Chemistry. He has authored numerous book chapters, practice guidelines, and peer-reviewed publications in the areas of clinical microbiology and molecular diagnostics.

Want to become more heart-centered? We invite you to join us on Deb's Dailies (daily blog and newsletter), a daily reflection on living and loving life as a heart-centered leader.Neil E. Grunberg, Ph.D., is a Professor of Military & Emergency Medicine and Neuroscience at the Uniformed Services University (USU) School of Medicine; Professor in the USU Graduate School of Nursing; and Director of Research and Development in the USU Leadership Education and Development (LEAD) program, Bethesda, Maryland. He also serves as the Director of Faculty Development for the Department of Military and Emergency Medicine and as the Chair, Faculty Mentoring and Development, Department of Anesthesiology. He is a medical psychologist, social psychologist, and behavioral neuroscientist. Dr. Grunberg earned baccalaureate degrees in Medical Microbiology and Psychology from Stanford University (1975); M.A. (1977), M.Phil. (1979), and Ph.D. (1980) degrees in Physiological Psychology and Social Psychology from Columbia University; and completed doctoral training in Pharmacology at Columbia University's College of Physicians & Surgeons (1976-79).He has been educating physicians, psychologists, and nurses for the Armed Forces and Public Health Service and scientists for research and academic positions since 1979. He has published > 220 papers addressing behavioral medicine, drug use, stress, traumatic brain injury, and leadership. He has been recognized for his professional contributions by awards from the American Psychological Association, Centers for Disease Control & Prevention, Food & Drug Administration, National Cancer Institute, Society for Behavioral Medicine, US Surgeon General, and Uniformed Services University. In 2015, Dr. Grunberg was selected to be a Presidential Leadership Scholar. He is a co-founder of the Healthcare Leadership Community of the International Leadership Association. He also is a member of Teaching Followers Courage. This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit debcrowe.substack.com

Dr Philip Smith, Digital and Education Editor of Gut and Honorary Consultant Gastroenterologist at the Royal Liverpool Hospital, Liverpool, UK interviews Professor Markus Gerhard from the Institute for Medical Microbiology, Immunology and Hygiene, School of Medicine, Technical University of Munich, Germany, on the paper "Helicobacter pylori promotes colorectal carcinogenesis by deregulating intestinal immunity and inducing a mucus-degrading microbiota signature" published in paper copy in Gut in July 2023 and available online: https://gut.bmj.com/content/72/7/1258   Please subscribe to the Gut Podcast via all podcast platforms, including Apple Podcasts, Google Podcasts, Stitcher and Spotify, to get the latest podcast every month. If you enjoy our podcast, please consider leaving us a review or a comment on the Gut Podcast iTunes page (https://podcasts.apple.com/gb/podcast/gut-podcast/id330976727).

On today's show Dr Sucharit Bhakdi considers the plan of the WHO to generally switch to mRNA vaccines as catastrophy waiting to happen. In this interview he will explain why. GUEST OVERVIEW: Professsor Sucharit Bhakdi MD is a retired Professor Emeritus of Medical Microbiology and Immunology, Former Chair, Institute of Medical Microbiology and Hygiene, Johannes Gutenberg University of Mainz. Professor Bhakdi is one the most important scientific critics of the reaction of governments to the COVID 19 disease and the mRNA vaccinations developed against it. Together with his wife, a professor for biochemistry, he wrote two bestselling book about the topic, one headed the German book charts for weeks. He faced fierce criticism for his concern, becoming the target of media campaigns and now faces a trial for antisemitism in Germany, which is considered as government induced smear attack to damage his reputation and silence his scientific criticism.

What does a coked up mouse act like? Professor of Medical Microbiology & Immunology Vanessa Sperandio tells us. Then Rep Robyn Vining joins to talk about some of the bills being voted on in the legislature next week that aren't going to get to the root of the labor shortage problem. Guests: Robyn Vining, Vanessa Sperandio

One Health is a concept which described the health not only of humans, but also of the envionment and animals. Our Guest, Dr Yogandree Ramsamy tells us about its origins, who governs the principles and how it can be applied to antimicrobial resistance and everyday clinical practice. About our Guest: Dr Yogandree Ramsamy, a medical doctor with a specialization in medical microbiology (MBChB, MMedPath (Microbiology), FCPath(SA)(Microbiology), PhD), is currently a Senior Pathologist in Medical Microbiology at JDJ Diagnostics. As a recipient of the One Health AMR Fellowship from the Université Paris Cité and Fondation Mérieux, the Institut Mérieux-ICAN Young Investigator Award in antimicrobial resistance (AMR), the L'Oreal-UNESCO for Women in Science Award and the SEDRIC-Wellcome Trust Travel Scholarship, Dr Ramsamy is extremely passionate about AMR and implementation of antimicrobial stewardship programs (ASPs). Currently a member of several local and international committees related to Antimicrobial Stewardship (AMS) and Infection Prevention and Control, Dr Ramsamy is committed to the fight against AMR. She has served on the provincial KZN Antimicrobial Stewardship (AMS) Committee, promoting the concept of AMR and AMS within the KZN public health sector in line with the South African National AMR Strategy. Her Master's focused on AMR, AMS and surveillance in the South African landscape and her PhD entailed investigating Carbapenem-resistant Enterobacterales (CRE) in a One Health context. She is a honorary research fellow in the Antimicrobial Research Unit at the University of KwaZulu-Natal. Her keen research interest in AMR, AMS and AMR surveillance has culminated in original research generating several publications + local and international conference presentations. Creating awareness of a bleak future without the prospects of lifesaving antimicrobials, mentoring up and coming individuals equally passionate about saving antimicrobials for future generations is one of her greatest ambitions.You can find Yogandree at:yogandree@gmail.comRamsamyy@ukzn.ac.zayogandree@jdj.co.za linkedin.com/in/yogandree-ramsamy-16a74a86Visit the Microbe Mail website to sign up for updates E-mail: mail.microbe@gmail.comYouTube: Microbe MailInstagram: Microbe_Mail

How do we, as doctors, prescribe antibiotics responsibly? Dr. Mackenzie Keintz, an Infectious Disease Fellow with the University of Nebraska chats with Dr. Block about antibiotics, antibiotic stewardship, when to prescribe them, what does antibiotic resistance really means, and how to avoid it. Dr Mackenzie Keintz graduated from the University of Wisconsin-Madison, majoring in Medical Microbiology and Immunology and Biology. She attended medical school at St. George's University, and completed her residency at the University of Nebraska Medical Center. Dr Keintz's Twiter: https://twitter.com/MKeintzMD   This episode is sponsored by Locumstory. For more information on Locumstory, go to https://locumstory.com/   The ideas expressed on this podcast are those of the interviewer and interviewee and do not represent those of their respective employers. Those on this podcast accept no liability for the outcomes of medical decisions based on this information. As the radiologists like to say "clinical correlation is required". This is not medical advice and this does not constitute a physician-patient relationship. If you have a medical problem, seek medical attention.  

There are few circumstances where receiving a package of human faeces is a welcome delivery, but for scientists in a Swiss laboratory, they were delighted. The Microbiota Vault Project is collecting stool samples in the hopes of building a global collection of gut bacteria so that the different species are not completely lost. But why is this necessary? Prof Adrian Egli is the Director of the Institute of Medical Microbiology and a member of the vault launch team and he joined Sean on the show to discuss… Image: Microbiota Vault

Rarely do I get an opportunity to be ahead of the curve with an invention interview that is genius. I have an informative and educational episode with Maurice Kemp the Co-Founder and CEO/President of Royal Caridea the Globes answer to daily fresh shrimp while at the same time, obliterating microbial contamination of multiple-frozen shrimp!ABOUT - Maurice KempI have a doctorate in Medical Microbiology with specialization in Virology. I have had both a career in academia, industry and government. My research interests emphasized control of pathogens of both man and animals, including those of shrimp. Worked on underlying mechanisms by which pathogens cause disease. I also worked and developed pharmaceutics, immuno-modulators as well as chemical agents directed at microbial contamination of our food supply. I have a very diverse background. Spent many years working in government and academia on projects related to disease control. As a result of a pharmaceutical consulting relationship I left academia. After my transfer to a pharmaceutical company I extended my studies on immunomodulators, wound healing and antivirals. After leaving the pharmaceutical company I co-founded a company devoted primarily to food and environmental safety. I was Chief Technology Officer (CTO) for this company, obtained chemical process and applications patents for the company. Spent considerable time solving problems domestically and internationally China and southeast Asia. Company was eventually sold.

Videos: Heather Mac Donald On How The Delusion of Diversity Destroys Our Common Humanity(11:02) This intense AI anger is exactly what experts warned of, w Elon Musk. (15:50) The FTX corruption is even worse than we thought | Redacted with Clayton Morris (13:00)   Almonds can help you cut calories University of South Australia, November 20, 2022 Weight loss is never an easy nut to crack, but a handful of almonds could keep extra kilos at bay according to new research from the University of South Australia. Examining how almonds can affect appetite, researchers found that a snack of 30-50 grams of almonds could help people cut back on the number of kilojoules they consume each day. Published in the European Journal of Nutrition, the study found that people who consumed almonds – as opposed to an energy-equivalent carbohydrate snack – lowered their energy intake by 300 kilojoules (most of which came from junk food) at the subsequent meal. “Our research examined the hormones that regulate appetite, and how nuts – specifically almonds – might contribute to appetite control. We found that people who ate almonds experienced changes in their appetite-regulating hormones, and that these may have contributed to reduced food intake (by 300kJ).” The study found that people who ate almonds had 47 per cent lower C-peptide responses (which can improve insulin sensitivity and reduce the risk of developing diabetes and cardiovascular disease); and higher levels of glucose-dependent insulinotropic polypeptide (18 per cent higher), glucagon (39 per cent higher), and pancreatic polypeptide responses (44 per cent higher). Glucagon sends satiety signals to the brain, while pancreatic polypeptide slows digestion which may reduce food intake, both encouraging weight loss. “Almonds are high in protein, fibre, and unsaturated fatty acids, which may contribute to their satiating properties and help explain why fewer kilojoules were consumed.” The findings of this study show that eating almonds produce small changes to people's energy intake, Dr Carter says this may have clinical effects in the long term. Probiotics help maintain a healthy microbiome when taken with antibiotics Texas Christian University, November 18 2022.  A systematic review published in the Journal of Medical Microbiology helps answer the question concerning whether probiotics should be taken along with antibiotics to support gut health.  Although probiotics decrease the adverse gastrointestinal effects caused by antibiotics, their ability to preserve intestinal microbial composition that is negatively impacted by antibiotic therapy is not well understood.  “Like in a human community, we need people that have different professions because we don't all know how to do every single job,” she explained. “And so, the same happens with bacteria. We need lots of different gut bacteria that know how to do different things.” While it is well known that antibiotics destroy some beneficial intestinal microorganisms, some healthcare professionals have expressed a concern that administering probiotics to antibiotic-treated patients could further alter the established gut microbe balance. The review included 29 studies published during a 7-year period. The authors concluded that consuming probiotics with antibiotics can prevent or reduce some changes caused by antibiotics to the microbiome. “When participants take antibiotics, we see several consistent changes in some bacterial species,” Dr Marroquin observed. “But when treatment was combined with probiotics, the majority of those changes were less pronounced and some changes were completely prevented.” New study shows repeated stress accelerates aging of the eye University of California, Irvine, November 21, 2022 New research from the University of California, Irvine, suggests aging is an important component of retinal ganglion cell death in glaucoma, and that novel pathways can be targeted when designing new treatments for glaucoma patients. The study was published today in Aging Cell. Along with her colleagues, Dorota Skowronska‐Krawczyk, Ph.D., at the UCI School of Medicine, describes the transcriptional and epigenetic changes happening in aging retina.  The team shows how stress, such as intraocular pressure (IOP) elevation in the eye, causes retinal tissue to undergo epigenetic and transcriptional changes similar to natural aging. And, how in young retinal tissue, repetitive stress induces features of accelerated aging including the accelerated epigenetic age. Aging is a universal process that affects all cells in an organism. In the eye, it is a major risk factor for a group of neuropathies called glaucoma. Because of the increase in aging populations worldwide, current estimates show that the number of people with glaucoma (aged 40-80) will increase to over 110 million in 2040. In humans, IOP has a circadian rhythm. In healthy individuals, it oscillates typically in the 12-21 mmHg range and tends to be highest in approximately two thirds of individuals during the nocturnal period. Due to IOP fluctuations, a single IOP measurement is often insufficient to characterize the real pathology and risk of disease progression in glaucoma patients.  Long-term IOP fluctuation has been reported to be a strong predictor for glaucoma progression. This new study suggests that the cumulative impact of the fluctuations of IOP is directly responsible for the aging of the tissue. Researchers now have a new tool to estimate the impact of stress and treatment on the aging status of retinal tissue, which has made these new discoveries possible. In collaboration with the Clock Foundation and Steve Horvath, Ph.D., from Altos Labs, who pioneered the development of epigenetic clocks that can measure age based on methylation changes in the DNA of tissues, it was possible for researchers to show that repetitive, mild IOP elevation can accelerate epigenetic age of the tissues. What do people experience at the border between life and death? University of London & New York University, November 20, 2022 A new study on near-death experiences featured 567 men and women whose hearts stopped while hospitalized in the United States and the United Kingdom. Out of 28 survivors of cardiac arrest interviewed as part of the study, 11 recalled memories suggesting consciousness while undergoing CPR.  Additional cardiac arrest survivors provided self-reports about what they experienced while their hearts stopped. Reports included perceiving separating from their bodies and meaningful examinations of their lives.  Researchers discovered spikes of brain activity up to an hour into CPR.  Dr. Parnia, who served as lead investigator of the study, explained that he and the other researchers undertook this research in an attempt to scientifically explore something that health professionals have discussed anecdotally for decades: The similar stories people revived by cardiopulmonary resuscitation (CPR) often tell about the time when their hearts stopped. “For decades now, millions of people who've gone through this have reported having lucid heightened consciousness, even though from the perspective of their doctors they were not conscious and they were in death,” Dr. Parnia told MNT. The study centered around 567 men and women who received CPR after their hearts stopped beating while at one of 25 participating hospitals in the United States and the United Kingdom.  When health practitioners began CPR on a patient whose heart stopped, researchers rushed to the scene, bringing along a portable electroencephalogram, or EEG, to monitor electrical activity in different parts of the brain, and near-infrared spectroscopy (NIRS) to measure oxygen saturation of superficial brain cortex regions. Taking care not to get in the way of health practitioners performing CPR, researchers also clamped a tablet computer above the patient's head. The tablet was connected to Bluetooth headphones which were placed on the patient's ears. Of 567 subjects, 213 or about 38% experienced sustained return of spontaneous circulation, meaning their pulse was restored for 20 minutes or longer. Only 53, or fewer than 10% of the participants, lived to be discharged from the hospital. Of those 53, 25 were unable to be interviewed by researchers due to poor health. The remaining 28 participants were interviewed 2 to 4 weeks after cardiac arrest depending on their recovery.  Of the 28 participants interviewed, 11 — or 39% — reported having memories during cardiac arrest. Two of the 28 participants could hear the medical staff working while receiving CPR. One participant recalled seeing the medical staff working and could feel someone rubbing his chest.  Using the near-death scale, six participants had transcendent experiences. Three participants reported dream-like experiences, which included a singing fisherman.  Six of the 28 participants interviewed remembered the experience of dying. These recollections included one person who heard a deceased grandmother telling her to return to her body.  “We characterize the testimonies that people had and were able to identify that there is a unique recalled experience of death that is different to other experiences that people may have in the hospital or elsewhere,” Dr. Parnia said, “and that these are not hallucinations, they are not illusions, they are not delusions, they are real experiences that emerge when you die.” Fifty-three participants had interpretable EEG data. Researchers discovered spikes of brain activity, including so-called gamma, delta, theta, alpha, and beta waves emerging up to 60 minutes into CPR. Some of these brain waves normally occur when people are conscious and performing functions like memory retrieval and thinking. According to the researchers, this is the first time such biomarkers of consciousness have been identified during CPR for cardiac arrest.  “We found the brain electrical markers of heightened […] lucid consciousness, the same markers as you get in people who are having memory retrievals who are having […] high order cognitive processes, except that this was occurring when the brain had shut down. Research suggests agmatine can boost brain health and uplift your mood naturally Yonsei University College of Medicine (S Korea), October 28, 2022. Athletes and bodybuilders are always eager to learn more about new products that can help enhance their workouts by promoting strength and stamina. Agmatine, a natural compound, is often used by health enthusiasts as a pre-workout supplement. According to research, agmatine can also potentially be used to boost brain health and improve mood. In one scientific review, researchers suggest that the compound can help prevent neurodegenerative diseases and assist in the recovery of brain injury patients. Agmatine or 4-aminobutyl-guanidine is produced in your body from arginine, an amino acid found in foods like chickpeas, lentils, pork and poultry. When used as a pre-workout supplement, experts recommend not taking it with protein since dietary protein can slow the absorption of agmatine. This then diminishes its benefits. Agmatine is often listed on supplement labels as agmatine sulfate. Dosages range between 250 mg to 1,000 mg per scoop, with intake recommendations between one to two grams per day. Agmatine has antioxidant and anti-inflammatory effects and can scavenge harmful free radicals that cause oxidative damage to your organs and tissues. Some people believe agmatine can help enhance workouts by increasing levels of beneficial nitric oxide. This then dilates blood vessels and promotes healthy circulation. Data also suggests that agmatine may help activate the release of pain-killing, mood-lifting endorphins, which can boost motivation and mood. This suggests taking agmatine can help make you feel more inclined to exercise. The compound may also help block aged glycation end products. Your body produces these potentially carcinogenic compounds after you eat charcoal-broiled or well-done meats. Agmatine may also help down-regulate matrix metalloproteinases (MMPs), which are tissue-degrading enzymes that can facilitate the spread of malignant tumors.  Studies show that agmatine works against the glutamate receptors that affect pain perception. Data from preliminary studies have supported agmatine's ability to reduce pain and strengthen the pain-killing effects of prescription opioids. Experts hope that agmatine can be used to help reduce the amount of medications needed and decrease the possibility of addiction to opioids. Supplementation with agmatine may help activate serotonin, the “feel good” chemical in your body while also decreasing levels of cortisol, the “stress” hormone that builds up when you are under duress. In a review published in the European Journal of Neuropsychopharmacology, scientists suggest that agmatine has antidepressant effects. According to a 2018 study published in the journal Human and Experimental Toxicology, agmatine can help protect brain cells from oxidative stress and inflammation caused by laboratory-induced Parkinson's. Prenatal phthalate exposure can significantly impact infant behavior and cognition, says study University of Illinois Urbana-Champaign, November 16, 2022 Prenatal exposure to phthalates, a set of chemicals commonly found in plastics and personal care products, has been shown to significantly impact aspects of behavior and cognition in infants, according to a team of researchers at the University of Illinois Urbana-Champaign. “Phthalates are widespread, and several well-known studies have reported that 100% of pregnant individuals had detectable levels of phthalates in their bodies,” said developmental neurotoxicologist Jenna Sprowles, a former postdoctoral research associate at the Beckman Institute for Advanced Science and Technology. Children's toys, cosmetics, and constructional materials are all potential sources of phthalate exposure, as are other materials made from polyvinyl chloride. When individuals who are pregnant are exposed to phthalates, the chemical compound crosses the placental barrier to interact directly with the fetus. Phthalates can also be transferred to a newborn through breast milk. Their study, reported in the journal Neurotoxicology and Teratology, investigated the neurobehavioral impacts of prenatal phthalate exposure in infants aged 4.5 and 7.5 months. Since many existing studies focus on individuals in early and middle childhood, providing attention to this age group is especially important. “Phthalates are endocrine-disrupting chemicals, meaning they interact with and alter how hormones typically act in the body. Hormones play crucial roles in brain development, so when the activities of hormones are altered by chemicals like phthalates, adverse functional effects are possible,” Sprowles said. “While we do know that different phthalates can affect different hormone systems, we don't yet know exactly how particular phthalates exert their specific effects.” The researchers found that the impact of prenatal phthalate exposure was specific to each phthalate's particular properties. For example, higher prenatal concentrations of a phthalate called MEP, which is commonly found in personal care products, were associated with lower ASQ scores (indicating below-average development) in certain domains. Their results align with existing studies, some of which have been carried out in animal models, which indicate that both prenatal and neonatal exposure to phthalates alters neural structure and function, resulting in impaired cognition and altered behavior.

Neil E. Grunberg, Ph.D., is Professor of Military & Emergency Medicine and Neuroscience in the Uniformed Services University (USU) School of Medicine; Professor in the USU Graduate School of Nursing; and Director of Research and Development in the USU Leadership Education and Development (LEAD) program, Bethesda, Maryland. He is a medical psychologist, social psychologist, and behavioral neuroscientist. Dr. Grunberg earned baccalaureate degrees in Medical Microbiology and Psychology from Stanford University (1975); M.A. (1977), M.Phil. (1979), and Ph.D. (1980) degrees in Physiological Psychology and Social Psychology from Columbia University; and completed doctoral training in Pharmacology at Columbia University's College of Physicians & Surgeons (1976-79). He has been educating physicians, psychologists, and nurses for the Armed Forces and Public Health Service and scientists for research and academic positions since 1979. He has published > 220 papers addressing behavioral medicine, drug use, stress, traumatic brain injury, and leadership. He has been recognized for his professional contributions by awards from the American Psychological Association, Centers for Disease Control & Prevention, Food & Drug Administration, National Cancer Institute, Society for Behavioral Medicine, US Surgeon General, and Uniformed Services University. In 2015, Dr. Grunberg was selected to be a Presidential Leadership Scholar. He co-founded the Healthcare Leadership Community of the International Leadership Association. He also is a member of Teaching Followers Courage.A Quote From This Episode"Everyone can be developed and can learn to be more effective leaders and more effective followers."About The International Leadership Association (ILA)The ILA was created in 1999 to bring together professionals interested in the study, practice, and teaching of leadership. The Prometheus ProjectAbout The Prometheus ProjectFocus Series Experience - Immunity to Change workshopMy Approach to HostingThe views of my guests do not constitute "truth." Nor do they reflect my personal views in some instances. However, they are important views to be aware of. Nothing can replace your own research and exploration.Connect with Scott AllenWebsite 

Joshua Veluz is a microbiologist and a licensed professional teacher. He is keen on discovering more applications of microorganisms that have the potential to propel the progress of human health, the environment, and society. We talked about studying the antifungal activity of Lactobacillus metabolites, medically relevant fungi and antifungal resistance, the roles marine microorganisms play in medical research, ESKAPE pathogens, working as a licensed professional teacher, and more. How to contact Joshua: Email: veluz.jt@gmail.com

Body Armor with Dr. Elaina George Dr. Elaina George is a Board Certified Otolaryngologist. She graduated from Princeton University with a degree in Biology, received her Master's degree in Medical Microbiology from Long Island University, and received her medical degree from Mount Sinai School of Medicine in New York. Dr. George completed her residency at Manhattan, Eye Ear & Throat Hospital. Her training included general surgery at Lenox Hill Hospital, pediatric ENT at The NY-Presbyterian Hospital, and head and neck oncology at Memorial Sloan-Kettering Cancer Center. As an independent solo practitioner in private practice who is also a small business owner, she has a unique perspective on the problems of health care delivery, the true costs of healthcare, and viable solutions, which seek to improve and restore the doctor patient relationship. Her interest in the politics of healthcare and the reform effort has led Dr. George to become both a powerful voice for the practicing physician and an advocate for the patient. Dr. George is a recipient of the Patients' Choice Award in 2008 and 2009. She has also been honored with membership in The Leading Physicians of the World and Who's Who Top Doctors Honors Edition. She is also on the advisory council of Project 21 black leadership network, an initiative of The National Center for Public Policy Research. She is a contributor to a wide variety of websites and is a recurring medical expert on a variety of shows including Your World with Neil Cavuto, and Newsmax. Website Living in the Solution with Dr. Elaina George

Videos: Dr. Ryan Cole: Covid Vaccine Side Effects Are Like A Nuclear Bomb New Rule: F*** tha Casting Police | Real Time with Bill Maher (HBO) Renters In America Are Running Out Of Options   Consuming green vegetables, supplements suppresses inflammatory bowel disease Sichuan University in China and from Cedars Sinai Medical Center, August 17, 2022 The dietary supplement chlorophyllin alleviates inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, according to researchers from the Center for Diabetes and Metabolism Research at Sichuan University in China and from Cedars Sinai Medical Center in Los Angeles. In addition, chlorophyllin significantly reduces mortality related to IBD, weight loss, diarrhea and hidden blood in the stool, intestinal epithelial damage and infiltration of inflammatory cells. The findings are published ahead of print in the American Journal of Physiology-Gastrointestinal and Liver Physiology, and the study has been chosen as an APS select article for August. Current therapeutics for IBD include medications that suppress the immune system (immunosuppressants) and surgery. However, long-term use of immunosuppressive treatments could result in severe adverse effects, including opportunistic infections and even organ failure. In this study, researchers found taking an oral chlorophyllin supplement—a compound derived from the green pigment found in plants—reduced colitis and abnormalities in the intestinal epithelia of mice. Also, consumption of green vegetables and chlorophyllin may be helpful for IBD recovery, in part through alleviation of inflammation and autolysosomal flux (a process that uses lysosome to degrade and remove toxic molecules and organelles). Green pigment found in these foods and supplements can initiate a feeding signaling to modulate autophagy in the cells, which suppresses IBD symptoms. (next) Coriander is a potent weapon against antibiotic resistant bacteria University of Beira Interior (Portugal) August 10, 2022 The problem of antibiotic resistant bacteria has been deemed a public health crisis, with the Centers for Disease Control and Prevention (CDC) reporting that invasive MRSA – or methicillin-resistant S. aureus – infections affect 80,000 people globally a year, and claim over 11,000 lives. But, what the CDC will never tell you is how coriander can potentially save lives. Researchers in Portugal now say that that the oil from coriander – a common kitchen spice – is quite toxic to a wide range of harmful bacteria, leading to hopes that it may be enlisted in the fight against MRSA and other pathogens. The scientific research about coriander is promising Researchers at University of Beira Interior used flow cytometry to study the effects of coriander oil on 12 different disease-causing types of bacteria, including E. coli, Salmonella, B. cereus and MRSA. In the study, published in Journal of Medical Microbiology, the oil significantly inhibited bacterial growth – especially that of MRSA and E. coli. (next) Tumour blood supply stopped in its tracks by modified natural compound University of New South Wales (Australia), August 10, 2022 Researchers have discovered how the modified natural compound dextran-catechin disrupts formation of blood vessels that fuel growth in the childhood cancer neuroblastoma. Researchers have discovered how a modified natural compound disrupts angiogenesis, the formation of blood vessel networks, in neuroblastoma tumours, stopping them laying down the vital supply lines that fuel cancer growth and spread. Dextran catechin is a sugar based conjugated form of catechin commonly found in green tea, red wine, dark chocolate and apple peels. Lead author Dr Orazio Vittorio of Children's Cancer Institute found that the natural polyphenol catechin slows tumour growth in the laboratory but breaks down too quickly in the body to be effective. (next) Researchers discover how DDT exposure contributes to Alzheimer's disease risk Florida International University and Rutgers University, August 17, 2022 A new study led by researchers from Florida International University and Rutgers reveals a mechanism linking the pesticide DDT to Alzheimer's disease. Published in Environmental Health Perspectives, the study shows how the persistent environmental pollutant DDT causes increased amounts of toxic amyloid beta, which form the characteristic amyloid plaques found in the brains of those with Alzheimer's disease. According to Jason Richardson, professor at FIU's Robert Stempel College of Public Health & Social Work and corresponding author, the study further demonstrates that DDT is an environmental risk factor for Alzheimer's disease.”The vast majority of research on the disease has been on genetics—and genetics are very important—but the genes that actually cause the disease are very rare,” Richardson says. “Environmental risk factors like exposure to DDT are modifiable. So, if we understand how DDT affects the brain, then perhaps we could target those mechanisms and help the people who have been highly exposed.” The study focused on sodium channels, which the nervous system uses to communicate between brain cells (neurons), as the potential mechanism. DDT causes these channels to remain open, leading to increased firing of neurons and increased release of amyloid-beta peptides. In the study, researchers demonstrate that if neurons are treated with tetrodotoxin, a compound that blocks sodium channels in the brain, the increased production of the amyloid precursor protein and toxic amyloid-beta species is prevented. “This finding could potentially provide a roadmap to future therapies for people highly exposed to DDT,” Richardson says. (next) Study shows how food preservatives may disrupt human hormones and promote obesity Cedars-Sinai Medicine Institute, August 9, 2022 Can chemicals that are added to breakfast cereals and other everyday products make you obese? Growing evidence from animal experiments suggests the answer may be “yes.” But confirming these findings in humans has faced formidable obstacles – until now. A new study published in Nature Communications details how Cedars-Sinai investigators developed a novel platform and protocol for testing the effects of chemicals known as endocrine disruptors on humans. The three chemicals tested in this study are abundant in modern life. Butylhydroxytoluene (BHT) is an antioxidant commonly added to breakfast cereals and other foods to protect nutrients and keep fats from turning rancid; perfluorooctanoic acid (PFOA) is a polymer found in some cookware, carpeting and other products; and tributyltin (TBT) is a compound in paints that can make its way into water and accumulate in seafood. The investigators used hormone-producing tissues grown from human stem cells to demonstrate how chronic exposure to these chemicals can interfere with signals sent from the digestive system to the brain that let people know when they are “full” during meals. When this signaling system breaks down, people often may continue eating, causing them to gain weight. (next) Standing desks can improve well-being, reduce stress among office workers University of Leicester (UK), August 17 2022 Standing desks can improve workers' performance as well as cut their time sitting by an hour each day, according to new research. Study authors add that getting up from an office chair also boosts well-being and energy levels, while reducing stress. “High levels of sitting time are associated with several health related outcomes and premature mortality, with high levels of workplace sitting associated with low vigor and job performance and high levels of presenteeism.” Presenteeism is the practice of being present at one's place of work for more hours than is required, especially as a manifestation of insecurity about one's job. Sedentary lifestyles increase the risk of chronic conditions including cardiovascular disease, type 2 diabetes, depression, anxiety, and cancer.

On Today's VR Podcast we meet Sarika (TrixxieZN), a Quest 2 Lover who spends a lot of her time in VR in Facebook Horizon Worlds. MORE ABOUT SARIKA: Sarika Mohabir is a South African VR world hopper, currently residing in Lake Las Vegas, Nevada. Even though she trained in Medical Microbiology...it didn't prepare her for the biggest challenge of all... motherhood... during a pandemic. Airborne diseases are hard...but kids are harder

The World Health Organisation (WHO) will convene its International Health Regulations Emergency Committee on 23 June, to assess whether the continuing Monkeypox outbreak represents a Public Health Emergency of International Concern. We speak to Dr. Chan Yoke Fun, Associate Professor and Head of Medical Microbiology at Universiti Malaya as to whether there should be any cause for concern and if Malaysia has a plan in place.Image Credit: Poetra.RH / Shutterstock.com

The World Health Organisation (WHO) will convene its International Health Regulations Emergency Committee on 23 June, to assess whether the continuing Monkeypox outbreak represents a Public Health Emergency of International Concern. We speak to Dr. Chan Yoke Fun, Associate Professor and Head of Medical Microbiology at Universiti Malaya as to whether there should be any cause for concern and if Malaysia has a plan in place.Image Credit: Poetra.RH / Shutterstock.com

A very successful pathogen - one that causes a spectrum of disease, from asymptomatic to life-threatening. On this episode we talk about Group A Streptococcus (Streptococcus pyogenes), the various types of infections that it causes and how to manage them. About our Guest: Dr Yesholata Mahabeer is a principal pathologist currently based at National Health Laboratory Service (NHLS) KwaZulu Natal academic complex at Inkosi Albert Luthuli Central Hospital in Durban. She studied medicine at the University of KwaZulu Natal. She subsequently completed her fellowship in microbiology in 1999 followed by Masters in Medical Microbiology in 2015. She has worked in several laboratories NLHS laboratories in Durban over the past 20 years. She currently oversees paediatrics, neurosurgery and haematology wards. Her interests include neurosurgical infections, mycology and antimicrobial susceptibility testing. She plays an active role in undergraduate and post graduate microbiology training. Visit the Microbe Mail https://microbemail.captivate.fm/ (website) to sign up for updates E-mail: mail.microbe@gmail.com YouTube: https://www.youtube.com/channel/UCgaP3aUNkjrgOxR8Ei6UaEw (Microbe Mail) Instagram: https://instagram.com/https:/www.instagram.com/microbe_mail/ (Microbe_Mail)  Pinterest: @mailmicrobe

Rapid molecular tests may assist in management of patients and assist in the fight against antimicrobial resistance, but they can be overused or misused. In order to optimise the test, there are a few do's and dont's when considering introducing these tests or requesting these tests. About our Guest: Dr Mohamed Said is a Clinical Microbiologist based at the National Health Laboratory Services Tshwane Academic Laboratory in Pretoria, South Africa. He is also a senior consultant at the Department of Medical Microbiology at the University of Pretoria since 2016. He did his undergraduate training at the University of Witwatersrand in Johannesburg, South Africa and completed specialist training at the University of Pretoria. He is actively involved in training of specialists in the field of Medical Microbiology and also supervises Science students. He serves on numerous committees within the National Health Laboratory Services as well as the Pharmacy and therapeutics committee of the Steve Biko Academic Hospital in Pretoria. He has published in peer reviewed journals in the fields of rapid molecular diagnostics, Group B Streptococcus disease and infection prevention and control. Dr Said has also presented his work at numerous national and international conferences in the forms of posters and oral presentations. Currently he is pursuing a PHD in the field of neonatal sepsis due to Group B Streptococcus. Visit the Microbe Mail https://microbemail.captivate.fm/ (website) to sign up for updates E-mail: mail.microbe@gmail.com YouTube: https://www.youtube.com/channel/UCgaP3aUNkjrgOxR8Ei6UaEw (Microbe Mail) Instagram: https://instagram.com/https:/www.instagram.com/microbe_mail/ (Microbe_Mail)  Pinterest: @mailmicrobe

Joining us on this episode is Dr. Jason Kindrachuk. Dr. Kindrachuk is an assistant professor in Medical Microbiology and Infectious Diseases at the University of Manitoba. In addition to this, he is also Canada Research Chair in the molecular pathogenesis of emerging viruses. His research primarily focuses on the circulation, transmission, and pathogenesis of emerging viruses. Currently, Dr. Kindrachuk is investigating the many complexities of viruses and what measures we can take to control them.  Listen now to explore topics like: Where viruses can exist in nature. How infectious diseases can spread through asymptomatic individuals. How recognizing the relationship between different viruses can help us combat future infections.  Offer: This episode is sponsored by Bowmar Nutrition. To receive a 5% discount, use the code GENIUS5 at checkout. Go to BowmarNutrition.com to shop now! With the proper analysis, can we curb the spread of viruses before they go too far? Follow along on this conversational journey with Dr. Kindrachuk to find out now! To learn more about Dr. Kindrachuk and his work, you can visit umanitoba.ca. Episode also available on Apple Podcasts: http://apple.co/30PvU9C

Welcome to our USMLE Prep Question and Answer series!We posed the following question on our social media (@sjsm_medicalschool) on Friday, April 15, 2022.In this episode of the series, Dr. Aqsaa Chaudhry will break down this USMLE Step 1 Prep question and explain how you can get to the correct answer in order to prepare for the USMLE Step 1 Exam!Question:  A 15-year-old boy comes to the clinic with complaints of a bump on his stomach. He noticed the lesion a few days ago. He is currently sexually active with multiple partners and does not use protection consistently. He has not had a sexually transmitted infection in the past and his last annual check-up was 2 years ago. The lesion is flesh-colored with central umbilication near the lower abdomen. What is the most probable cause of this patient's lesion?a. DNA virus, non-enveloped, single- stranded and linear structureb. DNA virus, non-enveloped, double- stranded and circular structurec. DNA virus, non-enveloped, double- stranded and linear structured. DNA virus, enveloped, partially double- stranded and circular structuree. DNA virus, enveloped, double- stranded and linear structureCORRECT:e) This patient's lesion describes molluscum contagiosum, a flesh-colored papule with central umbilication. Molluscum contagiosum belongs to the poxvirus family and is a enveloped, double- stranded linear DNA virus. It is often seen in children, however may be sexually transmitted in adults.Shandera, Wayne X., and Eva Clark.. "Other Exanthematous Viral Infections." Current Medical Diagnosis and Treatment 2020 Eds. Maxine A. Papadakis, et al. New York, NY: McGraw-Hill,, http://ezproxy.sjsm.org:2096/content.aspx?bookid=2683§ionid=225055143."Classification of Medically Important Viruses." Review of Medical Microbiology & Immunology: A Guide to Clinical Infectious Diseases, 15e Eds. Warren Levinson, et al. New York, NY: McGraw- Hill, , http://ezproxy.sjsm.org:2096/content.aspx?bookid=2381§ionid=187690830.INCORRECT:a) Parvovirus virus, a non-enveloped, single- stranded linear DNA virus, presents as erythema infectiosum (fifth disease, “slapped cheek” rash) in children. It may also present as aplastic crisis in sickle cell disease patients or hydrops fetalis.b) Papillomavirus is a non-enveloped, single- stranded circular DNA virus, the family is human papilloma virus (HPV), which can cause papillomas (warts) without central umbilication and certain strains can lead to cervical carcinoma.c) Adenovirus is a non-enveloped, double- stranded linear DNA virus, that may present with febrile pharyngitis, upper and lower respiratory tract disease.d) Hepadnavirus is an enveloped, partially double- stranded circular DNA virus, that leads to hepatitis B virus that may lead to either acute or chronic hepatitis."Classification of Medically Important Viruses." Review of Medical Microbiology & Immunology: A Guide to Clinical Infectious Diseases, 15e Eds. Warren Levinson, et al. New York, NY: McGraw- Hill, , http://ezproxy.sjsm.org:2096/content.aspx?bookid=2381§ionid=187690830.| Socials |Med School Minutes Podcast: https://www.buzzsprout.com/1904744Instagram: https://www.instagram.com/sjsm_medica...Facebook: https://www.facebook.com/mdsjsmLinkedIn: https://www.linkedin.com/school/saint...Website: https://www.sjsm.orgStore: https://sjsmstore.com* These links are affiliated with the channel and support the channel when used*

Guests: Dr. Jason Kindrachuk - Assistant Professor (Department of Medical Microbiology), University of Manitoba Rachel Manion - Executive Director, Canadian Skin Patient Alliance (CSPA) Madeleine Shaw - Author, "The Greater Good" Gail Attara - Gastrointestinal Society/Canadian Society of Intestinal Research   See omnystudio.com/listener for privacy information.

Hello everyone!Welcome to episode 95. Remous Ocloo, originally from Ghana but now located in South Africa, is my guest today.His father and sibling encouraged him to pursue a career in science. He actually wanted to be a doctor, but it didn't work out. He takes us on a journey through his academic career, describing some of the highs and lows along the way. He talks about how a setback helped him qualify for a prestigious scholarship that allowed him to study for his master's degree and now his PhD in South Africa. Remous is currently a PhD student in medical microbiology, and his research focuses on understanding how antimicrobial resistance develops and disseminates within and between humans and animals through the food chain, as well as how this can lead to new antimicrobial resistance policies. He explains the significance of this research in great detail. Finally, we talked about how he manages his work-life balance so that he may perform at his best as a scientist. Tune in for this and more!LinkedIn: Remous OclooSupport the show (https://paypal.me/RootofSciPod?locale.x=en_US)