Podcasts about American Journal

Today, I want to tell you a story that sounds like it was completely made up for a movie script, but it's 100% real. Imagine an automotive mechanic in Argentina. He has zero medical training, no background in obstetrics, and no clinical degree. One night, he sees a simple party trick on YouTube: how to get a lost cork out of the inside of an empty wine bottle using nothing more than an inflated plastic bag. Most people would laugh, finish their glass of wine, and move on. But this mechanic, Jorge Odón, looked at that plastic bag and had a radical thought: Could this same basic physics principle be used to safely deliver a trapped baby during second-stage labor? Fast forward through years of engineering refinements, global partnerships, and early clinical pilots, and we get the Odón device- or OdonAssist™. It is, without a doubt, one of the most creative and innovative mechanical concepts to hit the field of operative vaginal delivery in generations. Instead of rigid metal blades applying direct compression, or high-pressure suction cups on the scalp, it uses an inflatable pneumatic cuff wrapped inside a lubricated, double-layered polyethylene sleeve. The inner layer grips the fetal vertex, while the outer layer glides smoothly against the vaginal walls, replacing high friction with plastic-on-plastic sliding action. But, and this is a big "but", as clinicians, we don't practice medicine based on good ideas or clever engineering alone. We practice based on rigorous, reproducible evidence on efficacy and safety. And that's where the narrative gets complicated. Although the device recently secured CE mark approval in Europe, it is not FDA approved in the United States. Why? Because despite nearly two decades of development, it is still facing a major shortage of large-scale Phase 3 comparative data (non-inferiority data). And the data it does have is not quite as impressive as its design would imply. Listen in for details. 1. Mottet N, et al. Safety and efficacy of the OdonAssist inflatable device for assisted vaginal birth: the BESANCON ASSIST study. American Journal of Obstetrics & Gynecology, 2023; 230, S947-S9582. Hotton EJ, Lenguerrand E, Wade J, et al. The OdonAssist inflatable device for assisted vaginal birth—the ASSIST II study (United Kingdom). Am J Obstet Gynecol. 2024;230(3S):S932-S946.e3.3. https://www.mnhi.com/odonassist (CE approval)4. ACOG PB 219; 2020.

Présente du Portugal à la Scandinavie, la mystérieuse culture campaniforme va changer une partie de l'Europe. Qu'était cette population ? Était-ce seulement une population ? Grâce à l'archéologie et à la génétique, partez sur les traces de cette culture qui continue de faire débattre les chercheurs. Oui, tout ça à cause d'un gobelet en forme de cloche.Retrouvez le script, la bibliographie complète et les crédits sonores et graphiques sur : https://ladentbleue.fr/culture-campaniforme-genetique-archeologieSuivez La Dent Bleue sur :

100 Folgen Vegan Performance Podcast: Wir blicken zurück auf unsere wichtigsten Erkenntnisse, kontroversesten Aussagen und spannendsten Gespräche rund um Ernährung, Training, Gesundheit und Veganismus. Welche Themen sind heute noch relevant – und wo hat sich unsere Sicht verändert? ------------------------------------------------------------------------ Dominiks Buch zur pflanzenbasierten Sporternährung im UTB-Verlag: https://www.utb.de/doi/book/10.36198/9783838560328 Dominiks Gesundheitscommunity: www.gsundes-hannover.de Dominiks Online-Knie-Kurs: https://gsundes-hannover.de/knieschmerzen/ Dominiks Online-Rücken-Kurs: https://copecart.com/products/34bd5abb/checkout Marcs veganes Online-Fitness-Coaching: https://vegainer-academy.com/ Marcs Online-Kurs: https://www.copecart.com/products/a50f88f2/checkout ------------------------------------------------------------------------ Werbung: Dieser Podcast wird unterstützt von der Firma Watson Nutrition. Die Firma bietet als einzige umfassend laborgeprüfte Nahrungsergänzungsmittel für eine optimierte Nährstoffversorgung. Zum Angebot zählen Multi-Supplemente, Mono-Supplemente, Sportsupplemente wie Kreatin oder auch Proteinriegel, Shakes und essenzielle Aminosäuren Mit dem Code veganperformance erhältst du 5 % Rabatt auf deine Bestellung.  Zur Firmenwebseite: Watson Nutrition ------------------------------------------------------------------------ Redaktionelle Anmerkungen Zum Thema intuitive Ernährung und langfristige Gewichtsabnahme – ab 00:18:08 Intuitive Ernährung ist nicht grundsätzlich „größtenteils unerforscht“. Es liegen systematische Übersichtsarbeiten vor, insbesondere zu Essverhalten, Körperbild und psychischem Wohlbefinden. Begrenzter ist die Evidenz dafür, dass intuitive Ernährung langfristig zu einer relevanten Gewichtsabnahme oder automatisch zum Normalgewicht führt. Auch die Aussage, dass nach fünf Jahren über 90 Prozent der Menschen wieder ihr Ausgangsgewicht erreichen oder darüber liegen, ist in dieser Allgemeingültigkeit nicht ausreichend belegt. Gewichtszunahmen nach Diäten sind häufig, die Ergebnisse unterscheiden sich aber je nach Intervention, Personengruppe und Nachbetreuung deutlich. Zum Einfluss von Alkohol auf die Muskelproteinsynthese – ab 00:27:33 Die im Podcast genannten 10 bis 20 Prozent stimmen nicht mit der vermutlich gemeinten Studie überein. Nach einer sehr hohen Alkoholzufuhr von 1,5 Gramm pro Kilogramm Körpergewicht war die Muskelproteinsynthese trotz Proteinzufuhr etwa 24 Prozent und bei Alkohol plus Kohlenhydraten etwa 37 Prozent geringer. Untersucht wurde die kurzfristige Muskelproteinsynthese, nicht der langfristige Muskelaufbau. Ein einzelnes Bier macht eine Trainingseinheit dennoch nicht wertlos. Zum Zusammenhang zwischen Schlafmangel und Energieaufnahme – ab 01:33:50 Die genannten 300 bis 400 zusätzlichen Kilokalorien beziehen sich nicht auf jede einzelne Stunde Schlafmangel. Eine Meta-Analyse zeigte unter experimentell verkürzten Schlafbedingungen im Durchschnitt eine etwa 385 Kilokalorien höhere tägliche Energieaufnahme als unter normalen Schlafbedingungen. Zum Einfluss von Hormonen auf das Abnehmen – ab 01:50:36 Hormone sind nicht lediglich eine Folge des Lebensstils. Besonders während der Menopause können hormonelle Veränderungen Körperzusammensetzung, Fettverteilung, Appetit und möglicherweise den Energieverbrauch beeinflussen. Sie setzen die Energiebilanz jedoch nicht außer Kraft, können die Gewichtskontrolle aber erschweren. Quellenverzeichnis Al Khatib, H. K., Harding, S. V., Darzi, J., & Pot, G. K. (2017). The effects of partial sleep deprivation on energy balance: A systematic review and meta-analysis. European Journal of Clinical Nutrition, 71(5), 614–624. American College of Obstetricians and Gynecologists. (2020). Physical activity and exercise during pregnancy and the postpartum period: ACOG Committee Opinion No. 804. Obstetrics & Gynecology, 135(4), e178–e188. Babbott, K. M., Cavadino, A., Brenton-Peters, J., Consedine, N. S., & Roberts, M. (2023). Outcomes of intuitive eating interventions: A systematic review and meta-analysis. Eating Disorders, 31(1), 33–63. Barbaresko, J., Bröder, J., Conrad, J., Szczerba, E., Lang, A., & Schlesinger, S. (2025). Ultra-processed food consumption and human health: An umbrella review of systematic reviews with meta-analyses. Critical Reviews in Food Science and Nutrition, 65(11), 1999–2007. Crimarco, A., Springfield, S., Petlura, C., Streaty, T., Cunanan, K., Lee, J., Fielding-Singh, P., Carter, M. M., Topf, M. A., Wastyk, H. C., Sonnenburg, E. D., Sonnenburg, J. L., & Gardner, C. D. (2020). A randomized crossover trial on the effect of plant-based compared with animal-based meat on trimethylamine-N-oxide and cardiovascular disease risk factors in generally healthy adults: Study With Appetizing Plantfood-Meat Eating Alternative Trial. The American Journal of Clinical Nutrition, 112(5), 1188–1199. Deutsche Gesellschaft für Ernährung & Österreichische Gesellschaft für Ernährung. (2025). Referenzwerte für die Nährstoffzufuhr (3. Aufl.). Deutsche Gesellschaft für Ernährung. Eaton, M., Probst, Y., Foster, T., Messore, J., & Robinson, L. (2024). A systematic review of observational studies exploring the relationship between health and non-weight-centric eating behaviours. Appetite, 199, Article 107361. EFSA Panel on Dietetic Products, Nutrition and Allergies. (2016). Dietary reference values for choline. EFSA Journal, 14(8), Article 4484. Fernández-Rodríguez, R., Bizzozero-Peroni, B., Díaz-Goñi, V., Garrido-Miguel, M., Bertotti, G., Roldán-Ruiz, A., & López-Moreno, M. (2025). Plant-based meat alternatives and cardiometabolic health: A systematic review and meta-analysis. The American Journal of Clinical Nutrition, 121(2), 274–283. Forschungsinstitut für pflanzenbasierte Ernährung & Veganuary. (2026). Gießener vegane Lebensmittelpyramide. Greendale, G. A., Sternfeld, B., Huang, M., Han, W., Karvonen-Gutierrez, C., Ruppert, K., Cauley, J. A., Finkelstein, J. S., Jiang, S.-F., & Karlamangla, A. S. (2019). Changes in body composition and weight during the menopause transition. JCI Insight, 4(5), Article e124865. Grider, H. S., Douglas, S. M., & Raynor, H. A. (2021). The influence of mindful eating and/or intuitive eating approaches on dietary intake: A systematic review. Journal of the Academy of Nutrition and Dietetics, 121(4), 709–727.e1. Hartmann-Boyce, J., Theodoulou, A., Oke, J. L., Butler, A. R., Bastounis, A., Dunnigan, A., Byadya, R., Cobiac, L. J., Scarborough, P., Hobbs, F. D. R., Sniehotta, F. F., Jebb, S. A., & Aveyard, P. (2023). Long-term effect of weight regain following behavioral weight management programs on cardiometabolic disease incidence and risk: Systematic review and meta-analysis. Circulation: Cardiovascular Quality and Outcomes, 16(4), Article e009348. Hevia-Larraín, V., Gualano, B., Longobardi, I., Gil, S., Fernandes, A. L., Costa, L. A. R., Pereira, R. M. R., Artioli, G. G., Phillips, S. M., & Roschel, H. (2021). High-protein plant-based diet versus a protein-matched omnivorous diet to support resistance training adaptations: A comparison between habitual vegans and omnivores. Sports Medicine, 51(6), 1317–1330. Intergovernmental Panel on Climate Change. (2023). Climate change 2023: Synthesis report (H. Lee & J. Romero, Eds.). IPCC. Kalhoff, H., Rudloff, S., Ensenauer, R., Hensel, K., Kauth, T., Posovszk, C., & Weihrauch-Blüher, S., für die Ernährungskommission der Deutschen Gesellschaft für Kinder- und Jugendmedizin. (2026). Vegetarische und vegane Ernährung bei Kindern und Jugendlichen – ein Update. Monatsschrift Kinderheilkunde. Advance online publication. Klug, A., Barbaresko, J., Alexy, U., Kühn, T., Kroke, A., Lotze-Campen, H., Nöthlings, U., Richter, M., Schader, C., Schlesinger, S., Virmani, K., Conrad, J., & Watzl, B. (2024). Update of the DGE position on vegan diet—Position statement of the German Nutrition Society. Ernährungs Umschau, 71(7), 60–84. Kreider, R. B., Kalman, D. S., Antonio, J., Ziegenfuss, T. N., Wildman, R., Collins, R., Candow, D. G., Kleiner, S. M., Almada, A. L., & Lopez, H. L. (2017). International Society of Sports Nutrition position stand: Safety and efficacy of creatine supplementation in exercise, sport, and medicine. Journal of the International Society of Sports Nutrition, 14, Article 18. Mountjoy, M., Ackerman, K. E., Bailey, D. M., Burke, L. M., Constantini, N., Hackney, A. C., Heikura, I. A., Melin, A., Pensgaard, A. M., Stellingwerff, T., Sundgot-Borgen, J. K., Torstveit, M. K., Jacobsen, A. U., Verhagen, E., Budgett, R., Engebretsen, L., & Erdener, U. (2023). 2023 International Olympic Committee's consensus statement on Relative Energy Deficiency in Sport. British Journal of Sports Medicine, 57(17), 1073–1097. Parr, E. B., Camera, D. M., Areta, J. L., Burke, L. M., Phillips, S. M., Hawley, J. A., & Coffey, V. G. (2014). Alcohol ingestion impairs maximal post-exercise rates of myofibrillar protein synthesis following a single bout of concurrent training. PLOS ONE, 9(2), Article e88384. Reed, K. E., Camargo, J., Hamilton-Reeves, J., Kurzer, M., & Messina, M. (2021). Neither soy nor isoflavone intake affects male reproductive hormones: An expanded and updated meta-analysis of clinical studies. Reproductive Toxicology, 100, 60–67. Richter, M., Tauer, J., Conrad, J., Heil, E., Kroke, A., Virmani, K., & Watzl, B. (2024). Alcohol consumption in Germany, health and social consequences and derivation of recommendations for action—Position statement of the German Nutrition Society. Ernährungs Umschau, 71(10), 125–139. Thomas, D. T., Erdman, K. A., & Burke, L. M. (2016). American College of Sports Medicine joint position statement: Nutrition and athletic performance. Medicine & Science in Sports & Exercise, 48(3), 543–568. U.S. Department of Health and Human Services & U.S. Department of Agriculture. (2026). Dietary Guidelines for Americans, 2025–2030 (10th ed.). Weidlinger, S., Winterberger, K., Pape, J., Weidlinger, M., Janka, H., von Wolff, M., & Stute, P. (2023). Impact of estrogens on resting energy expenditure: A systematic review. Obesity Reviews, 24(10), Article e13605.

Description:  Hosts Roz and Dr. Sanchez-Fueyo are joined by Alessia Giarraputo to discuss the key articles of the August issue of the American Journal of Transplantation. Alessia Giarraputo is a postdoc research fellow at Mass General Hospital and Harvard Medical School [3:38] Donor-reactive clonotypes are overrepresented in the urinary T cell repertoire during kidney transplant rejection and show distinct dynamics in the circulation [13:57] Organ-specific differences in the epidemiology of cytomegalovirus infections in high-risk (cytomegalovirus donor seropositive, recipient seronegative) solid organ transplant recipients with prolonged follow-up: A 10-year experience [22:17] Immune checkpoint inhibitors after liver transplantation: The role of immunosuppressive management [28:34] Expert consensus on the use of immune checkpoint inhibitors in the liver transplant setting: Guidance from the Liver Transplant Committee of the Italian Association for the Study of the Liver (AISF) [33:50] Outcomes of kidney transplants from pediatric donors with acute kidney injury

Send us Fan MailThe countdown to the first day of school is on.If you're like most school leaders, your to-do list is growing by the hour. Schedules, staffing, professional development, open houses, and a flood of emails can make August feel like a race to simply get everything done.But what if the key to a successful school year isn't checking off more tasks?In this episode of The Empowered Educator Show, Dr. Mel challenges a common mindset that keeps many principals stuck in reactive leadership long after the first bell rings. Instead of focusing on everything that needs to be completed before students arrive, you'll discover a different way to prepare—one that can shape the entire school year.Through the lens of the Leader • Logistics • Learning framework, Dr. Mel shares practical insights, leadership stories, and research-backed principles that will help you think differently about the weeks leading up to the start of school.If you want to lead with greater clarity, confidence, and purpose this year, this episode is for you.In This EpisodeWhy being busy isn't the same as being preparedThe hidden mistake many school leaders make every AugustThree simple shifts that can have a lasting impact on your school cultureResearch-based leadership insights that support sustainable successA biblical perspective on leading with wisdom and intentionalityA practical challenge you can implement before the first day of schoolResources MentionedHorng, E. L., Klasik, D., & Loeb, S. (2010). Principal Time-Use and School Effectiveness. American Journal of Education, 116(4), 491–523.The Wallace Foundation. (2021). How Principals Affect Students and Schools: A Systematic Synthesis of Two Decades of Research.Gallup. State of the Global Workplace (latest editions).ScriptureProverbs 24:3 – "By wisdom a house is built, and through understanding it is established."Support the showMillion Podcasts ListDownload Upside and use my code MELINDA35278 to get 15¢ per gallon extra cash back on your first gas fill-up and 10% extra cash on your first food purchase!Download Fetch app using this link, submit a receipt and we'll both score bonus points.Calling All Educators! I started a community with resources, courses, articles, networking, and more.I am looking for members to help me build it with the most valuable resources.I would really appreciate your input as a teacher, leader, administrator, or consultant.Join here: Empowered Educator CommunityBook: Educator to Entrepreneur: IGNITE Your Path to Freelance Successemail: melinda@empowereducator.com

#044 Rebroadcast You know what we're talking about. That spectacular fizzy geyser. This week, Melissa and Jam explore what makes diet coke and mentos go crazy together. Is it love? Is it hate? Is it chemistry? Why diet coke specifically? Or more importantly, why mentos? Let's get into it. Support this podcast on Patreon Buy Podcast Merch and Apparel Check out our website at chemforyourlife.com Watch our episodes on YouTube Find us on Instagram, Twitter, and Facebook @ChemForYourLife References from this episode Diet Coke and Mentos: What is really behind this physical reaction? - American Journal of Physics 76, 551 (2008) Diet Coke and Mentos: What is really behind this physical reaction? - Tonya Coffey Spurting Science: Erupting Diet Coke with Mentos - Scientific American - Science Buddies   Thanks to our monthly supporters Sara Hull Dog Day Dan Bri . Summer Alden Amanda Raymond Kyle McCray Justine Ash Vince W Julie S. Heather Ragusa Autoclave Dorien VD Scott Beyer Jessie Reder J0HNTR0Y Cullyn R Erica Bee Elizabeth P Rachel Reina Letila Katrina Barnum-Huckins Suzanne Phillips Venus Rebholz Jacob Taber Brian Kimball Kristina Gotfredsen Timothy Parker Steven Boyles Chris Skupien Chelsea B Avishai Barnoy Hunter Reardon Support this podcast on Patreon Buy Podcast Merch and Apparel Check out our website at chemforyourlife.com Watch our episodes on YouTube Find us on Instagram, Twitter, and Facebook @ChemForYourLife   Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Allt fler oinbjudna besökare tar sig in i våra hem. Lyssna på alla avsnitt i Sveriges Radios app. Skadedjur har alltid krupit vid människans sida. Forskare tror att de blodtörstiga vägglössen fanns redan i stenålderns grottboningar. Genom historien har olika typer av ohyra inte bara gett oss kliande bett och förstört våra matförråd, utan också orsakat några av mänsklighetens mest förödande sjukdomsepidemier.Under några decennier på 1900-talet, när en rad nya och kraftfulla bekämpningsmedel gjorde entré, såg det ut som att människan äntligen höll på att vinna den tusenåriga kampen mot krypen.Men segervittringen blev kortvarig. Skadedjuren är tillbaka. De blir fler, de sprider sig till nya platser – och de har blivit allt svårare att bekämpa.Programledare och producent: Anna Lillkung och Wendela AntepohlOrdlistaVektor – en organism, till exempel en råtta eller en kackerlacka, som för över smittämnen mellan varelser.Patogen – ett sjukdomsframkallande smittämne, till exempel ett virus eller en bakterie.Mikrob – en organism som är så liten att den inte syns med blotta ögat, till exempel ett virus eller en bakterie.Resistens – en organisms förmåga att stå emot yttre påfrestningar, till exempel en bakterie som utvecklat motståndskraft mot en eller flera typer av antibiotika.KällförteckningMedverkandeThomas Persson Vinnersten – Biolog och entomolog på AnticimexLisa Sarasohn – Historiker och författare till Getting Under Our Skin: The Cultural and Social History of VerminBobby Corrigan – Skadedjursbiolog med fokus på gnagareÅke Lundkvist – Professor i virologi vid Uppsala universitetTuomas Aivelo – Assisterande professor i biodiversitet och samhälle vid Leiden University i Nederländerna och grundare till Helsinki Urban Rat ProjectJose Pietri – Docent i mikrobiologi och entomologi vid Purdue UniversityBöckerGetting Under Our Skin: The Cultural and Social History of Vermin (Lisa T. Sarasohn, 2021)Rats : A Year With New York's Most Unwanted Inhabitants (Robert Sullivan, 2004)Plagues, Poisons, and Dead Rats: A Multispecies History (Lucinda Cole, ur boken The Palgrave Handbook of Animals and Literature, 2020)Never Home Alone (Rob Dunn, 2020)Artiklar/källor i urvalSkadedjur i byggnader – en kunskapssammanställning (Malmö universitet på uppdrag av Boverket, 2025)Challenges in current pest management practices: Navigating problems and a way forward by integrating controlled release system approach (Singh et al., Chemical Engineering Journal, 2024)How pest control has changed in 100 years (Rentokil, 2025)Studie: Myror lika bra som gifter mot skadedjur (SvD, 2022)“They're always there”: resident experiences of living with rats in a disadvantaged urban neighbourhood (BMC Public Health, 2019)Increasing rat numbers in cities are linked to climate warming, urbanization, and human population (Science Advances, 2025)Reconsidering the “War on Rats”: What We Know From Over a Century of Research Into Municipal Rat Management (Corrigan, Himsworth, Byers, m.fl, Frontiers in Ecology and Evolution, 2022)Surveillance of Emerging Rodent-Borne Pathogens in Wastewater in Taiwan: A One Health Approach (Tropical Medicine and Infectious Disease, 2024)Bedbugs Could Be More Horrifying Than You Think. They might be capable of spreading disease, recent research shows. (The Atlantic, 2024)Anticoagulant rodenticides and resistance development in rodent pest species – A comprehensive review (Journal of Stored Products Research, 2020)Public Health Significance of Urban Pests (World Health Organization, 2008)Rodenticide Toxicity (StatPearls Publishing, 2026)Increasing rat numbers in cities are linked to climate warming, urbanization, and human population (ScienceAdvances, 2025)Public and media interest in bed bugs – Europe 2023 (Current Research in Insect Science, 2024)Large-scale structure of brown rat (Rattus norvegicus) populations in England: effects on rodenticide resistance (PeerJ, 2015)”Hysterisk” ökning av klädesmal (Sveriges Radio, 2015)Second hand–trend bidrar till att fler har problem med pälsmal i hemmen: ”Var extra noga om du köper möbler” (Smålandsposten, 2023)De äter på mattor och kläder – så blir du av med klädmal (Göteborgs-Posten, 2024)Revenge of the clothes moths: as numbers boom, can they be stopped? (The Guardian, 2019)High prevalence of hepatitis E and rat hepatitis E viruses in wastewater in Gothenburg, Sweden (One Health, 2024)Lessons learned from bat and rodent reservoir hosts of zoonotic viruses (Trends in microbiology, 2026)Human ectoparasites and the spread of plague in Europe during the Second Pandemic (Proc Natl Acad Sci U S A, 2018)Yersinia pestis: the Natural History of Plague (Clinical Microbiology Reviews, 2020)Disruption of the microbiota affects physiological and evolutionary aspects of insecticide resistance in the German cockroach, an important urban pest (PloS one, 2018)Case not closed: arguments for new studies of the interactions between bed bugs and human pathogens (The American Journal of Tropical Medicine and Hygiene, 2020)Microbiome differences between human head and body lice ecotypes revealed by 16S RRNA gene amplicon sequencing (The Journal of Parasitology, 2020)Do bed bugs transmit human viruses, or do humans spread bed bugs and their viruses? A worldwide survey of the bed bug RNA virosphere (Virus Research, 2024)Competence of Cimex lectularius Bed Bugs for the Transmission of Bartonella quintana, the Agent of Trench Fever (PLoS Negl Trop Dis., 2015)Ratmageddon: Why rats are overrunning our cities (BBC, 2025)‘Perfect rat storm': urban rodent numbers soar as the climate heats, study finds (The Guardian, 2025)Global population divergence and admixture of the brown rat (Rattus norvegicus) (Biological Sciences, 2016)Highly Pathogenic Leptospira Found in Urban Brown Rats (Rattus norvegicus) in the Largest Cities of Sweden. (Vector Borne and Zoonotic Disease, 2015)First evidence of Seoul hantavirus in the wild rat population in the Netherlands (Infection Ecology & Epidemiology, 2015)Pet rat harbouring Seoul hantavirus in Sweden (Eurosurveillence, 2013)Seoul Hantavirus Frequently Asked Questions (Wisconsin department of health services)Leptospira Status in Sweden during the Past Century, Neglected and Re-Emerging? (Microorganisms, 2023)Bed bug infestations: prevalence, correlates, and cross-sectional association with psychological symptoms in a large sample of tenants in Montreal, Canada (BMC Public Health, 2025)Anticimex: Trendbrott för vägglöss – 19 procent fler saneringar 2025 (Anticimex, 2026)Rats infest Gaza's tent camps, biting children and spreading disease (Reuters, 2026)Reconsidering the “War on Rats”: What We Know From Over a Century of Research Into Municipal Rat Management (Frontiers in ecology and evolution, 2022)Cockroaches as urban pests: Challenges, public health implications, and management strategies (One Health, 2026)HURP: Helsinki Urban Rat ProjectHow did the cruise ship hantavirus outbreak start? Scientists are investigating new scenarios (Science, 2026)A timeline of the hantavirus outbreak on cruise ship (AP, 2026)Hantavirus outbreak linked to cruise ship travel, Multi-locations (World Health Organization, 2026)Sjukdomsinformation om hantavirusinfektion (Folkhälsomyndigheten)Mjölbaggar erövrar studentboendet: ”Inte mitt hem längre” (SVT, 2025)Silent Carriers: The Role of Rodents in the Emergence of Zoonotic Bacterial Threats (Pathogens, 2025)8 av 10 stockholmare har sett råttor (Anticimex, 2019)Silverfiskar vanligast men inte så farliga (Hem & Hyra, 2017)MusikGeoff Barrow, Ben Salisbury – Dream RealityCristobal Tapia De Veer – Pain SpeedballKid Loco – Theme from the Graffiti ArtistMarcus Bagalà – Duco in Mara's RoomCliff Martinez – I'm in the PinkMarcus Bagalà – Frets: Problem, After ProblemMartin D Fowler – 1 Ships VIIRamin Djawadi – Winter is ComingAlberto Iglesias – TreasureCliff Martinez – Save Some For UsJocelyn Pook – Driving to PrisonCliff Martinez – I'm SickAlice Cooper – PoisonCliff Martinez – Placental RepairJessica Dannheisser, Adele Roberts – Parade of the GeeseCliff Martinez – Speight Lived HereOchre – Midsummer Nice DreamMarcus Bagalà – Wires: WinchimesMichael Andrews – Peter and SylvieK2 – Bexar BexarCliff Martinez – Navy FuneralMike Patton – Murder is WorkMartin D Fowler – 1 Ships XIITrent Reznor, Atticus Ross – Empty Places (Reprise)Cliff Martinez – Same SweatpantsCristobal Tapia De Veer – The PublicJeff Beal – I think I Smell GasTrentemöller – Take Me Into Your SkinTrent Reznor, Atticus Ross – Clue OneKyle Dixon, Michael Stein – ElevenStar Hopper – Through the HeliopausePaul Leonard-Morgan – Anderson's ThemeMartin D Fowler – 1 Ships IIIJon Brion – You LearnThe Mariachis – La Cucaracha

Political conflicts related to immigration are thorny enough on their own. The issues and challenges intensify once we add to the mix our warming planet and its relationship to migration, immigration, and human displacement. Two 2024-25 CASBS fellows – Maureen Eger, a sociologist of immigration, and Alice Farmer, a refugee lawyer specializing in climate change and displacement – discuss scholarly and policy dimensions of the climate migration landscape in conversation with Pulitzer Prize-winning journalist John Markoff (CASBS fellow, 2017-18). Maureen Eger: USC faculty page | personal website | Google Scholar page | Alice Farmer: LinkedIn page |  Read John Markoff's latest book, Whole Earth: The Many Lives of Stewart Brand  (Penguin Random House, 2022). John's next book, expected in 2027, will be published by MIT Press. Referenced in the episode or related works L. Yang, M. Eger, and Link, eds. Migration Stigma: Understanding Prejudice, Discrimination, and Exclusion (MIT Press, 2024) M. Eger and S Valdez, "From Radical Right to Neo-nationalist," European Political Scientist (2019) M. Eger, M. Hjerm, and P. Velasquez, "What is the Liberalizing Potential of Higher Education? An Analysis of Academic Fields and Anti-Immigrant Sentiment Across 32 Countries," The British Journal of Sociology (2025) M. O'Brien and M. Eger, "Suppression, Spikes, and Stigma: How COVID-19 Will Shape International Migration and Hostilities toward It," International Migration Review (2020) L. Yang, M. Eger, and B. Link, "The Human Cost of Politicizing Immigration: Migration Stigma, US Politics, and Health," JAMA (2024) A. Farmer and K. Linos, "Tools to Finance Climate Mobility: An Introduction to the Symposium," American Journal of International Law (2025) A. Farmer, "Disasters in Slow Motion: Why Climate Displacement Tests International Legal Frameworks, and What to Do about it," University of Pennsylvania Journal of International Law (2026) J. Bittle, The Great Displacement: Climate Change and the Next American Migration (Simon & Schuster, 2024) G. Vince, Nomad Century: How Climate Migration will Reshape our World (Macmillan, 2022) A. Lustgarten, On the Move: The Overheating Earth and the Uprooting of America (Macmillan, 2024) T. Hale, Long Problems: Climate Change and the Challenge of Governing Across Time (Princeton Univ. Press, 2024) Center for Advanced Study in the Behavioral Sciences (CASBS) at Stanford UniversityExplore CASBS: website | Bluesky | X | YouTube |LinkedIn | podcast | latest newsletter | signup | outreach​Human CenteredProducer: Mike Gaetani | Audio engineer & co-producer: Joe Monzel

For this Managed Care Cast episode, The American Journal of Managed Care® (AJMC®) spoke with Anuraag R. Kansal, PhD, who leads health economics research at GRAIL, about his study, “State Medicaid Budgetary Implications of New Cancers," published in the July 2026 issue; it examined how new cancer diagnoses affected state Medicaid budgets. He conducted the study with Amanda C. Chen, PhD, of the USC Mann School of Pharmacy and Pharmaceutical Sciences, and David C. Grabowski, PhD, of Harvard Medical School. Kansal explained to AJMC that despite Medicaid's younger population, cancer remains the third-largest source of program spending. Most existing research had focused on commercial and Medicare populations rather than Medicaid specifically. Consequently, using de-identified CMS claims data, he and his team identified new cancer diagnoses, defined as no prior cancer evidence in the preceding 6 months, and compared spending, hospitalizations, and emergency department use between metastatic and non-metastatic cases. Kansal highlighted the core finding, which was that metastatic diagnoses were associated with significantly higher spending than non-metastatic diagnoses across most cancer types. Notably, health care utilization patterns were consistent between fee-for-service and capitated Medicaid states, suggesting that cost drivers stemmed from the disease itself, particularly the shift to systemic therapies once cancer spread, rather than from program administration models. Kansal pointed to the 4 cancer screenings recommended by the US Preventive Services Task Force, namely lung, breast, colorectal, and cervical, as opportunities to reduce late-stage diagnoses and their associated costs while noting that cancers without established screening protocols presented a distinct policy challenge. On balancing innovative treatment access with cost sustainability, he emphasized that Medicaid's state-by-state administration means that no single policy solution applied universally. Still, Kansal emphasized that earlier detection could offer states greater financial flexibility to support innovative therapies for patients with true clinical need. “Intervening earlier is one of the opportunities we might have to really make a difference,” he concluded.

Today, we're diving straight into a topic that hits close to home for millions of patients and providers alike: IUD insertion pain, and more importantly, how we can actually make it better. Now, if you've been practicing or following clinical guidelines for a while, you know the frustrating backstory here. For years, the standard advice was simple: "Just take 800 milligrams of ibuprofen an hour before your appointment." But a 2015 double-blinded, randomized placebo-controlled clinical trial showed that taking a single dose of 800 mg within an hour before insertion did not relieve procedural pain. That was published in the journal Contraception in 2015. This left clinicians wishing for better options. Fast forward to 2024, when the CDC updated its guidelines to formally recommend local analgesia, like lidocaine blocks or topical use, to help manage insertion pain. That was a huge, long-overdue win for patient-centered care. But local numbing isn't the only tool we should be looking at. What if the issue with oral NSAIDs wasn't the medication itself, but how and when we dosed it? That brings us to a brand-new study published in the American Journal of Obstetrics and Gynecology (AJOG), August 2026. Researchers looked at a preemptive, multidose ibuprofen regimen- starting the day before insertion to reach sustained, therapeutic blood levels ahead of time. And the results? They offer some new insights into how we can stack our pain control strategies. So, let's break down what this study found, how it builds on our CDC guidance, and what it means for our clinical practice starting at our next IUD placement. Let's jump in. 1. Bednarek PH, Creinin MD, Reeves MF, et al. Contraception. 2015;91(3):193–197.2. Ouyang C, Lamvu G, Quach H, et al. Multidose Ibuprofen Prior to Intrauterine device insertion (MIPI): a triple blinded randomized controlled trial. American Journal of Obstetrics & Gynecology, August 2026; 235, 330-3373. Management of Premenstrual Disorders: ACOG Clinical Practice Guideline No.7 Obstetrics and Gynecology. 2023. Committee on Clinical Practice Guidelines–Gynecology4. McKenna KA, Fogleman CD. Dysmenorrhea.American Family Physician. 2021.

Warum suchen manche Menschen ständig den nächsten Kick, während andere vor allem in emotionalen Momenten Entscheidungen treffen, die sie später bereuen? In dieser Folge von Betreutes Fühlen schauen Leon und Atze auf die vielen Gesichter der Impulsivität: Sensation Seeking, emotionale Impulse und die Frage, warum manche Menschen besser innehalten können als andere. Eine Folge über die Kunst, sich manchmal treiben zu lassen – und manchmal besser nicht. Fühlt euch gut betreut Leon & Atze Instagram: https://www.instagram.com/leonwindscheid/ https://www.instagram.com/atzeschroeder_offiziell/ Mehr zu unseren Werbepartnern findet ihr hier: https://linktr.ee/betreutesfuehlen Tickets: Atze: https://www.atzeschroeder.de/#termine Leon: https://leonwindscheid.de/tour/ Quellen Berg, J. M., Latzman, R. D., Bliwise, N. G., & Lilienfeld, S. O. (2015). Parsing the heterogeneity of impulsivity: A meta-analytic review of the behavioral implications of the UPPS for psychopathology. Psychological Assessment, 27(4), 1129–1146. https://doi.org/10.1037/pas0000111 Chase, H. W., & Ghane, M. (2023). Seeking pleasure, finding trouble: Functions and dysfunctions of trait sensation seeking. Current Addiction Reports, 10(2), 140–148. https://doi.org/10.1007/s40429-023-00484-5 Fisher-Fox, L., Prestigiacomo, C. J., & Cyders, M. A. (2024). Urgency theory in the context of broader emotion theories: A conceptual review. Frontiers in Psychiatry, 15, Article 1403639. https://doi.org/10.3389/fpsyt.2024.1403639 Mallard, T. T., Tubbs, J. D., Jennings, M., Zhang, Y., Gustavson, D. E., Grotzinger, A. D., … Sanchez-Roige, S. (2026). Characterizing the pleiotropic architecture of impulsivity and its links to psychopathology and neurodevelopment. American Journal of Psychiatry, 183(1), 31–47. https://doi.org/10.1176/appi.ajp.20240382 Maples-Keller, J. L., Berke, D. S., Few, L. R., & Miller, J. D. (2016). A review of sensation seeking and its empirical correlates: Dark, bright, and neutral hues. https://doi.org/10.1037/14854-008 McCabe, C. J., Louie, K. A., & King, K. M. (2015). Premeditation moderates the relation between sensation seeking and risky substance use among young adults. Psychology of Addictive Behaviors, 29(3), 753–761. https://doi.org/10.1037/adb0000075 Psychology Today. (2000, November). Are you a risk taker? https://www.psychologytoday.com/us/articles/200011/are-you-a-risk-taker Reuters. (2026, July 1). Two people unfurl peace banner from New York's Empire State Building spire. https://www.reuters.com/world/two-people-unfurl-peace-banner-new-yorks-empire-state-building-spire-2026-07-01 Sperry, S. H., Lynam, D. R., Walsh, M. A., Horton, L. E., & Kwapil, T. R. (2016). Examining the multidimensional structure of impulsivity in daily life. Personality and Individual Differences, 94, 153–158. https://doi.org/10.1016/j.paid.2016.01.018 The Guardian. (2024, July 16). Skywalkers: A Love Story review. https://www.theguardian.com/film/article/2024/jul/16/skywalkers-a-love-story-review Verma, A. K., & Chivukula, U. (2023). The effect of affect, sensation seeking, and premeditation on risky decision-making: Conditional process analysis. PLOS ONE, 18(2), e0281324. https://doi.org/10.1371/journal.pone.0281324 Wormington, B., Imms, P., & Derks, E. M. (2026). To lump or not to lump: Evidence for impulsivity as a multidimensional construct. American Journal of Psychiatry, 183(1), 4–6. https://doi.org/10.1176/appi.ajp.20240382 Wüllhorst, V., Lützkendorf, J., & Endrass, T. (2024). Validation of the German long and short versions of the UPPS-P Impulsive Behavior Scale. Journal of Clinical Psychology, 80(10), 2099–2116. https://doi.org/10.1002/jclp.23724 Reaktion: Julia Ditzer Produktion: Murmel Productions

Podcast family, we pride ourselves on this show on being avant-garde and forward thinking on the topics we choose. For example, on February the 20th, 2026, we released an episode called “New Data: Screen Maternal Ferritin with Prenatal Care?” In that episode we reviewed a publication from the previous month (January 2026) that was released in Lancet Hematology. This study made the case for screening for early iron deficiency, even without anemia, with serum ferritin at the initiation of prenatal care. This was a multicenter, 2-arm, randomized controlled trial. Earlier identification of low serum ferritin prevented iron deficiency anemia in the third trimester. That's a win! Back then, we also stated how Australia has been leading the charge on this with the Australian HOW. That stands for Hematology in Obstetrics and Women's Health. This Australian consensus committee now recommends screening for iron deficiency, not just iron deficiency anemia, at the initiation of prenatal care, at 24 to 28 weeks, and then again at the third trimester when necessary. And now, as of August 2026, we have additional supportive data that including serum ferritin at the initial OB visit is evidence-based and best for the patient! In this episode we will review this brand-new, prospective cohort study published as a Research Letter in the AJOG August 2026.1. Australian HOW: Iron optimisation in pregnancy: a Haematology in Obstetric and Women's Health Collaborative consensus statement; https://onlinelibrary.wiley.com/doi/10.1111/imj.166022. Konecke N, Jackson T, Angeles I. et al. The association between first trimester iron deficiency without anemia and the development of iron-deficiency anemia prior to childbirth. American Journal of Obstetrics & Gynecology, 2026; 235, e36-e383. ACOG Clinical Practice Update: An Update to Clinical Guidance for Delayed Umbilical Cord Clamping After Birth in Preterm Neonates. Obstet Gynecol. 2025 Jul 24;146(3):442-444.

Over two decades ago, Lipoprotein(a)—or Lp(a)—was recognized as an emerging risk factor for cardiovascular disease. In this special edition of DOC Updates, Dr. Neil Skolnik explores our growing understanding of this cholesterol-carrying lipoprotein. This special episode is sponsored with support from Lilly. Please listen to the episodes by clicking on the podcast player below or by freely subscribing to DOC Updates via Apple Podcasts, Amazon Music, Spotify, or your preferred podcast platform. EPISODE NOTES Special Edition: Special Edition: Lp(a) & CV Risk In this special edition of DOC Updates, Neil Skolnik speaks with Dr. Michael Wilkinson, who goes over the history of Lp(a), the current guidelines, and the importance of screening. This special episode is sponsored with support from Lilly. Presented by: -Neil Skolnik, MD, Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Associate Director, Family Medicine Residency Program, Abington Jefferson Health -Michael Wilkinson, MD, Associate Professor of Medicine at University of California San Diego Health, and Director of the advanced lipid treatment program at UC San Diego Health, Board of Directors of the National Lipid Association and Associate editor of the American Journal of Preventive Cardiology References: -The American Heart Association PREVENT Online Calculator -Lipoprotein(a) as a Pharmacological Target: Premises, Promises, and Prospects – Circulation 2025; 151:400-415 -2026 ACC/AHA/AACVPR/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Dyslipidemia: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation Volume 153, Issue 17, 28 April 2026; Pages e1154-e1276

What if some of the most powerful ways to improve your health didn't require expensive gadgets, complicated routines, or the latest supplement trend? In this rapid-fire solo episode, Darin shares 15 unusual, science-backed habits that can dramatically improve longevity, mobility, brain function, nervous system regulation, digestion, and overall vitality. From dead hangs and deep squats to humming, sunlight, boredom, and chewing your food more thoroughly, each practice is grounded in published research, not internet biohacking hype. These are simple, practical habits you can start today that may have an outsized impact on your health over time. If you're looking for evidence-based ways to optimize your body without spending a fortune, this episode is packed with actionable takeaways. What You'll Learn Why grip strength may be one of the strongest predictors of longevity How deep squats improve mobility and joint health The surprising connection between balance and lifespan Why humming boosts nitric oxide production The science behind mouth taping and nasal breathing How cold water can instantly calm your nervous system Why boredom fuels creativity and brain function The health benefits of intentional silence How awe can reduce inflammation Why soil microbes strengthen your immune system The importance of chewing for nutrient absorption Why sunlight is one of the most powerful daily health tools Chapters 00:00:00 – Welcome to SuperLife 00:00:32 – Sponsor: Tru Niagen 00:02:35 – 15 science-backed health habits you probably aren't doing 00:04:18 – #1 Grip strength and longevity 00:06:40 – #2 The deep squat rest 00:08:16 – #3 Single-leg balance 00:09:36 – #4 Why humming boosts nitric oxide 00:11:01 – #5 Mouth taping and nasal breathing 00:12:41 – #6 Cold water face immersion 00:14:05 – #7 Ice on the back of your neck 00:14:59 – Sponsor: Manna Vitality 00:16:55 – #8 Getting bored on purpose 00:18:34 – #9 Scheduling daily silence 00:20:01 – #10 Chasing awe instead of scrolling 00:21:20 – #11 Why getting your hands dirty boosts immunity 00:23:00 – #12 Chewing your food more thoroughly 00:24:20 – #13 Squatting while using the bathroom 00:25:41 – #14 Get sunlight before your phone 00:26:59 – #15 Sunlight on your skin 00:28:28 – The complete 15-step daily protocol 00:29:05 – Start with one habit today 00:29:26 – Final thoughts and closing message Thank You to Our Sponsors Tru Niagen: Boost NAD+ levels for cellular health and longevity. Get 20% off with code DARINOLIEN20 at truniagen.com. Manna Vitality: Go to mannavitality.com/ and use code DARIN for 20% off your order. Join the SuperLife Community Get Darin's deeper wellness breakdowns — beyond social media restrictions: Weekly voice notes Ingredient deep dives Wellness challenges Energy + consciousness tools Community accountability Extended episodes Join for $7.49/month → https://patreon.com/darinolien Connect with Darin Olien: Website: darinolien.com Instagram: @darinolien Book: Fatal Conveniences Platform & Products: superlife.com New Show: Roadmap to Happiness Key Takeaway "Better health doesn't always come from doing more—it often comes from returning to the simple things humans have done for thousands of years. Move your body naturally. Breathe through your nose. Spend time in silence. Get into the sun. Touch the earth. Challenge your balance. Strengthen your grip. These aren't expensive biohacks—they're timeless biological signals that remind your body how to thrive. Small daily actions, repeated consistently, can create extraordinary long-term health." Bibliography/Sources Physical Function & Biomechanics Araujo, C. G., et al. (2022). Successful 10-second one-legged stance performance predicts survival in middle-aged and older individuals. British Journal of Sports Medicine https://www.frontiersin.org/journals/sports-and-active-living/articles/10.3389/fspor.2022.1066913/full Deep squat / ankle dorsiflexion as clinical mobility assessment. (n.d.). PubMed Central. https://pmc.ncbi.nlm.nih.gov/articles/PMC7276781/ https://pmc.ncbi.nlm.nih.gov/articles/PMC12358486/ Leong, D. P., et al. (2015). Prognostic value of grip strength: Findings from the Prospective Urban Rural Epidemiology (PURE) study. The Lancet, 386(9990), 266–273. https://doi.org/10.1016/S0140-6736(14)62000-6 Sikirov, D. (2003). Comparison of straining during defecation in three positions: Results and implications for human health. Digestive Diseases and Sciences, 48(7), 1201–1205. https://doi.org/10.1023/A:1024180319005 Respiratory & Nervous System Effects of cold stimulation on cardiac-vagal activation in healthy participants: A randomized controlled trial. (n.d.). PubMed Central. https://pmc.ncbi.nlm.nih.gov/articles/PMC6334714/ Systematic review of mouth taping for sleep-disordered breathing. (2024). PLOS One. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0323643 Trigeminocardiac / mammalian dive reflex response to cold facial immersion. (2023). PubMed Central. https://pmc.ncbi.nlm.nih.gov/articles/PMC10295257/ Weitzberg, E., & Lundberg, J. O. N. (2002). Humming greatly increases nasal nitric oxide. American Journal of Respiratory and Critical Care Medicine, 166(2), 144–145. https://pubmed.ncbi.nlm.nih.gov/12119224/ Brain, Silence & Emotion Bartoli, E., et al. (2024). Default mode network electrical stimulation effects on creativity. Brain, 147(10), 3409+. Bernardi, L., Porta, C., & Sleight, P. (2006). Cardiovascular, cerebrovascular, and respiratory changes induced by different types of music in musicians and non-musicians: The importance of silence. Heart, 92, 445–452. https://pubmed.ncbi.nlm.nih.gov/16199412/ Mann, S., & Cadman, R. (2014). Does being bored make us more creative? Creativity Research Journal, 26(2), 165–173. https://doi.org/10.1080/10400419.2014.901073 Münzel, T., et al. (2024). Noise causes cardiovascular disease: It's time to act. Journal of Exposure Science & Environmental Epidemiology. https://pmc.ncbi.nlm.nih.gov/articles/PMC11876066/ Stellar, J. E., John-Henderson, N., Anderson, C. L., Gordon, A. M., McNeil, G. D., & Keltner, D. (2015). Positive affect and markers of inflammation: Discrete positive emotions predict lower levels of inflammatory cytokines. Emotion, 15(2), 129–133. Immune, Digestion & Environmental Light Cassady, B. A., Hollis, J. H., Fulford, A. D., Considine, R. V., & Mattes, R. D. (2009). Mastication of almonds: Effects of lipid bioaccessibility, appetite, and hormone response. The American Journal of Clinical Nutrition, 89(3), 794–800. https://pubmed.ncbi.nlm.nih.gov/19144727/ Liu, D., Fernandez, B. O., Hamilton, A., et al. (2014). Isolated UVA irradiation of human skin generates dermal nitric oxide and lowers blood pressure independent of vitamin D. Journal of Investigative Dermatology, 134(7), 1839–1846. https://pubmed.ncbi.nlm.nih.gov/24445737/ Morning light exposure and circadian phase-shifting / dim-light melatonin onset. (n.d.). PubMed Central. https://pmc.ncbi.nlm.nih.gov/articles/PMC10594521/ Rook, G. A. W., et al. (2023). The old friends hypothesis: Evolution, immunoregulation and essential microbial inputs. Frontiers in Allergy. https://pmc.ncbi.nlm.nih.gov/articles/PMC10524266/ Strachan, D. P. (1989). Hay fever, hygiene, and household size. BMJ, 299(6710), 1259–1260. https://doi.org/10.1136/bmj.299.6710.1259

Are inherited metabolic disorders more common, and less predictable, than we previously thought? Large-scale genomic studies are identifying adults with disease-associated variants who have escaped diagnosis, sometimes despite lifelong symptoms. At the same time, expanding genomic newborn screening risks identifying children who may remain well for decades or never develop clinically significant disease at all. In this episode Dr Nina Gold, Dr Jessica Gold, and Professor Mirjam Langeveld, explore the tension between missed diagnosis and overdiagnosis and ask, when does knowing more genuinely help? Are Inherited Metabolic Disorders More Common and Less Predictable Than We Thought? N Gold et al https://doi.org/10.1002/jimd.70094 Screening for Life: Perspectives From Adult Metabolic Specialists on Newborn Screening for Inherited Metabolic Diseases. M Langeveld, et al. https://doi.org/10.1002/jimd.70057 Exclusion-based exome sequencing in critically ill adults 18–40 years old has a 24% diagnostic rate and finds racial disparities in access to genetic testing. American Journal of Human Genetics J Gold et al https://www.cell.com/ajhg/fulltext/S0002-9297(25)00238-1 Long-term Penetrance of Disease Variants in Genes Prioritized for Genomic Newborn Screening. Gold NB, et al. https://www.medrxiv.org/content/10.64898/2026.06.10.26355380v1 - pre-print not peer reviewed

A reading of articles and features from the June/July 2026 Issue of the Polish American Journal

The fertilization report looked good. You had eggs. They fertilized. Day three looked fine. Then came the call. Nothing made it past day five, or one did, and it was graded poor, and the cycle was over. You were told it was egg quality, or it was a numbers game, or that you have to try again. Here is what that explanation leaves out. An embryo does not run on one engine the whole way. For the first two to three days it runs almost entirely on the egg, on the proteins, the messenger molecules, and the energy the egg packed during its final growth phase. Then, around the four to eight cell stage on day three, the embryo activates its own genome and takes over, and the paternal contribution comes online. That handover changes where you look. If development stalls in the first three days, you start with the egg and its energy supply. If it looked strong on day three and stalled before the blastocyst, you start with the sperm and its DNA. Same line in the report. Two completely different first moves. Most workups examine neither. They adjust the protocol and go again. In this episode, I walk through the seven factors that shape whether an embryo keeps dividing, and what most clinics never review before they tell you it was your eggs. Pull it up, take notes, and bring it to your next appointment. TIMESTAMPS 00:00 The day five call and what the explanation leaves out 00:55 If this show has helped you, leave a review 01:05 Who reviews your case at Fab Fertile 03:50 Number one: the day three handover and where to look first 06:10 Number two: the egg's energy supply was built before the cycle 08:05 Number three: sperm DNA fragmentation and the standard semen analysis 09:20 Number four: the full thyroid panel, including antibodies 10:20 The Embryo Audit Checklist 10:40 Number five: blood sugar and insulin, for both of you 11:45 Number six: inflammation, the gut microbiome, oxidative stress 12:40 Number seven: the ninety day window and why repeating a cycle repeats the result 13:45 Why the data driven approach works for left brain people 14:30 Chromosomal quality is information, not a verdict 14:55 The Functional Fertility Second Opinion WHAT THE RESEARCH SHOWS A standard semen analysis measures count, motility, and shape. It does not measure the integrity of the DNA inside the sperm. Sperm carrying damaged DNA can still fertilize an egg and produce a normal-looking embryo on day two or three, and development can stall after the genome handover. In a 2025 retrospective analysis of 870 fresh single blastocyst ICSI cycles, each one percent increase in sperm DNA fragmentation was associated with roughly 2.5 percent lower odds of obtaining a top quality blastocyst on day five. The same analysis found that fragmentation was not predictive of clinical pregnancy outcomes. It speaks to why an embryo stalled, not to whether a pregnancy will happen. Thyroid autoantibodies have been detected in follicular fluid at concentrations that correlate with blood levels, which is one reason a complete thyroid panel may include Free T3, Free T4, Reverse T3, TPO antibodies, and thyroglobulin antibodies rather than TSH alone. These are not established diagnostic tests for embryo arrest. They can provide context that a single TSH result cannot. THE EMBRYO AUDIT CHECKLIST If your embryos have arrested and you want to walk through what to review before the next cycle repeats the same result, we built the Embryo Audit Checklist for exactly this. Download it at https://fabfertile.com/pages/embryo-audit-checklist Or email hello@fabfertile.ca, subject line CHECKLIST. FUNCTIONAL FERTILITY SECOND OPINION This is a call where I review your cycle, your labs, your history, and your partner's picture together in one place. You leave knowing what your embryos may be telling you and what the next cycle would be built on, instead of repeating the same outcome. Whatever you decide afterward is yours, but it gets made with information your workup did not give you. Book at https://fabfertile.com/pages/book Or email hello@fabfertile.ca, subject line FERTILE. ABOUT THE HOST I'm Sarah Clark, founder of Fab Fertile and host of Get Pregnant Naturally, a podcast with over one million downloads. My functional fertility team works with couples navigating low AMH and failed IVF, reviewing functional lab results, gut microbiome, food sensitivity, vaginal microbiome, nutrigenomics, HTMA, DUTCH, toxin testing, and bloodwork alongside nervous system work, to help identify patterns that may not have been considered. We work alongside your medical team, not instead of them. Subscribe to Get Pregnant Naturally for weekly episodes on fertility optimization, IVF preparation, and the lab work your doctor probably isn't running. Sarah Clark, founder of Fab Fertile, host of Get Pregnant Naturally (1M+ downloads), and author of Fabulously Fertile. If this episode helped you make sense of your own numbers, leave a review wherever you listen. It is how another woman, being told the same thing, finds her way here. REFERENCES Machałowski T, Machałowska J, Gill K, et al. Sperm DNA Fragmentation Impairs Early Embryo Development but Is Not Predictive of Pregnancy Outcomes: Insights from 870 ICSI Cycles. International Journal of Molecular Sciences. 2025. doi:10.3390/ijms26167923 Monteleone P, Parrini D, Faviana P, et al. Female infertility related to thyroid autoimmunity: the ovarian follicle hypothesis. American Journal of Reproductive Immunology. 2011. American Urological Association and American Society for Reproductive Medicine. Diagnosis and Treatment of Infertility in Men: AUA/ASRM Guideline. 2020.

For decades, RICE (Rest, Ice, Compression, and Elevation) was the standard advice for treating acute injuries. In this episode, we explore the history of RICE, why sports medicine is rethinking the role of ice, and what current research says about inflammation, healing, and recovery. We discuss the origins of RICE with Dr. Gabe Mirkin, the arguments presented in Gary Reinl's ICED!, the influential PEACE & LOVE framework, and the latest evidence from randomized controlled trials and systematic reviews examining cryotherapy and injury management. Whether you're a runner, coach, or simply interested in evidence-based recovery, this episode breaks down the science behind one of the most common injury treatments in sports medicine.Research discussed: Bleakley et al. (2004), American Journal of Sports Medicine; Bleakley et al. (2006), British Journal of Sports Medicine; van den Bekerom et al. (2012), Journal of Athletic Training; Dubois & Esculier (2020), British Journal of Sports Medicine; Horschig et al. (2024), Journal of Contemporary Chiropractic.Connect with Us:Our website: https://www.marathonjournal.comInstagram: https://www.instagram.com/runningpodcastYouTube: https://youtube.com/@marathonjournalFollow us on Strava: https://www.strava.com/athletes/30798607

What do cigarettes, dementia risk and food cravings have in common? They're all part of a fascinating new series of papers in the American Journal of Public Health examining ultra-processed foods. Research scientist and clinical psychologist Dr. Erica LaFata helps us understand the science behind food addiction, brain health, industry influence and what these findings mean for our everyday food choices. Ultra-Processed Foods – with Erica Lafata, PhDLINKSAmerican Journal of Public Health: Ultra-Processed Foods Special Section | https://bit.ly/43JnOP0About Erica LaFata, PhD | https://bit.ly/4vhWaVx Molly's past podcast, The Truth about Food Addiction, with Ashley Gearhardt, PhD | https://bit.ly/4ozGGcQ A sampling of Dr. LaFata's publications on ultra-processed foods: LaFata EM, Moran AJ, Volkow ND, Gearhardt AN. Now Is the Time to Recognize and Respond to Addiction to Ultra-Processed Foods. Nature Medicine. 2025. doi:10.1038/s41591-025-03858-6LaFata EM, Gearhardt AN. Ultra-Processed Food Addiction: An Epidemic? Psychother Psychosom. 2022;91(6):363-372. doi: 10.1159/000527322. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

「安慰剂」在新药研发过程中处处可见，amylose 和 amylopectin是安慰剂糖丸的主要成分，其实就是淀粉（标题注释）。安慰剂效应究竟是应该被消除的统计噪声，还是一种被低估的真实治疗机制？当一针生理盐水能让帕金森患者的大脑释放出与真药相当的多巴胺，当假手术的疗效与真手术完全持平。我们要回答的问题是：如果安慰剂这么强，新药研发的投入还有意义吗？如果安慰剂能治病，我们可以只给病人吃糖丸吗？这期节目我们一起聊聊安慰剂效应在大脑中究竟通过哪些神经通路起效；它为什么越来越强以至于成为新药研发的障碍；我们可以只用安慰剂来治病吗？时间轴[00:14] 怀特先生的故事：一针盐水就让肿瘤消失了[02:54] 二战护士用生理盐水冒充吗啡止痛，战士不疼了[06:22] 不光吃药，手术也有安慰剂效应[12:32] 安慰剂不光能安慰，还能「反安慰」[19:10] 安慰剂管用的三条神经通路：内源性阿片系统、多巴胺奖赏系统、HPA 轴[28:32] 安慰剂成了新药上市的绊脚石[39:31] 临床试验如何对付安慰剂效应[44:14] 只用安慰剂能治病吗？

On this episode of Managed Care Cast, The American Journal of Managed Care® (AJMC®) was joined by Erin L. Duffy, PhD, MPH, an author of a study published in the June 2026 issue. She is a health policy researcher at the Schaeffer Center for Health Policy & Economics at the University of Southern California, with a focus on health care affordability, access to care, and how health systems can better serve patients. Duffy's study, "Availability of Hospital Financial Assistance Documents in Non-English Languages," found that nonprofit and system-affiliated hospitals have superior language access. During her conversation with AJMC, she discussed what inspired the research, the study's key findings, and ways to improve equitable access to information about financial assistance, regardless of language. To conclude, Duffy previewed her study to be published in the July 2026 issue of AJMC, which builds on this work by evaluating the readability of financial assistance documents.

Episode 2821 - Vinnie Tortorich and Chris Shaffer discuss marketing ploys by Big Food, poorly done food studies, and that exercise is king. https://vinnietortorich.com/2026/07/exercise-is-king-episode-2821 PLEASE SUPPORT OUR SPONSORS Pure Vitamin Club Pure Coffee Club NSNG® Foods VILLA CAPPELLI EAT HAPPY KITCHEN YOU CAN WATCH THIS EPISODE ON YOUTUBE - @FitnessConfidential Podcast Vinnie's workout videos are available to purchase! Choose from a 2-day, 4-day, or 6-day workout–or buy all three at a discount! TO PURCHASE VINNIE'S WORKOUT VIDEOS, CLICK THIS LINK: https://vinnietortorich.com/workout Exercise is King Vinnie tells a story of "who is influencing whom?" (3:00) We can all do better, encourage each other, and be an example. The American Journal of Public Health recently published an article that highlights the connections between the marketing approaches of Big Food and Big Tobacco. (13:00) Lunchables are marketed as having a good amount of protein; however, the breakdown shows otherwise. (19:00) Big Food's entire goal is to get you addicted to their products. (28:00) You can find a book focusing on this topic in Vinnie's Book Club on his Amazon page. The book is "Salt, Sugar, Fat" by Michael Moss: https://www.amazon.com/dp/B07DF5QS3H?linkCode=ssc&tag=vinnitorto-20&creativeASIN=B07DF5QS3H&asc_item-id=amzn1.ideas.DLRU885XQ4BV&ref_=cm_sw_r_cp_ud_aipsfshop_aipsfvinnietortorich_109ME21EYG8380MBNX34_asin It appears that the American Heart Association finally agrees with what Vinnie has been saying for years: exercise is a poor way to lose weight. (43:00) Exercise is king for health and longevity! However, you need to eat real food, too. Another epidemiological study on meat consumption; however, it compares processed meats (like salami, pepperoni) to white meat, such as chicken (not processed). The comparison is off, so the outcome is off. (50:00) For a recent study on drinking tea, the article included all kinds of caveats, but the article about meat did not. Update on the PVC Magnesium product. (1:05:30) Anna's products are now linked to PureVitamin Club's website. Look under the "Food and Snacks" section to purchase them there, too. https://purevitaminclub.com/collections/food-and-snacks Vinnie hopes to add other products as well, all of which will be health-related. The NSNG® VIP GROUP IS NOW CLOSED AGAIN AS OF SUNDAY, MARCH 15TH Anna's next cookbook, Eat Happy Cocktail Hour, is filled with cocktails, mocktails, and appetizers and is available for pre-order right now. If you pre-order, you'll get bonus goodies! You can preorder from a wide variety of booksellers at https://eathappycocktailhour.com/ Save your receipt from wherever you preorder, you'll need it for your bonuses! Physical Release Date is October 2026 You can book a consultation with Vinnie to get guidance on your goals. https://vinnietortorich.com/phone-consultation-2/ More News Serena has added some of her clothing suggestions and beauty product suggestions to Vinnie's Amazon Recommended Products link. Self Care, Beauty, and Grooming Products that Actually Work! https://www.amazon.com/shop/vinnietortorich/list/3GPVU29UHHPMY?ref_=aipsflist Don't forget to check out Serena Scott Thomas on Days of Our Lives on the Peacock channel. "Dirty Keto" is available on Amazon! You can purchase or rent it here.https://amzn.to/4d9agj1 Please make sure to watch, rate, and review it! Eat Happy Italian, Anna's second cookbook, is available! You can go to https://eathappyitalian.com You can order it from Vinnie's Book Club. https://amzn.to/3ucIXm Anna's recipes are in her cookbooks, on her website, and on Substack —they will spice up your day! https://annavocino.substack.com/ PURCHASE DIRTY KETO (2024) The documentary launched in August 2024! Order it TODAY! This is Vinnie's fourth documentary in just over five years. Visit my new Documentaries HQ to find my films everywhere: https://vinnietortorich.com/documentaries Then, please share my fact-based, health-focused documentary series with your friends and family. Additionally, the more views it receives, the better it ranks, so please watch it again with a new friend! REVIEWS: Please submit your REVIEW after you watch my films. Your positive REVIEW does matter! PURCHASE BEYOND IMPOSSIBLE (2022) Visit my new Documentaries HQ to find my films everywhere: https://vinnietortorich.com/documentaries FAT: A DOCUMENTARY 2 (2021) Visit my new Documentaries HQ to find my films everywhere: https://vinnietortorich.com/documentaries FAT: A DOCUMENTARY (2019) Visit my new Documentaries HQ to find my films everywhere: https://vinnietortorich.com/documentaries

Ep. #812 | One of the most critical habits for improving erections, and a simple mental approach to help you get it done.Inquiries: contact@holisticalpha.comStudiesKhera M, Bhattacharyya S, Miller LE. (2023). Effect of aerobic exercise on erectile function: Systematic review and meta-analysis of randomized controlled trials. Journal of Sexual Medicine.https://academic.oup.com/jsm/article/20/12/1369/7301709https://pubmed.ncbi.nlm.nih.gov/37814532/Gerbild H, Larsen CM, Graugaard C, Areskoug Josefsson K. (2018). Physical activity to improve erectile function: A systematic review of intervention studies. Sexual Medicine.https://pmc.ncbi.nlm.nih.gov/articles/PMC5960035/Silva AB, Sousa N, Azevedo LF, et al. (2017). Physical activity and exercise for erectile dysfunction: Systematic review and meta-analysis. British Journal of Sports Medicine.https://pubmed.ncbi.nlm.nih.gov/27707739/Esposito K, Giugliano F, Di Palo C, et al. (2004). Effect of lifestyle changes on erectile dysfunction in obese men: A randomized controlled trial. JAMA.https://jamanetwork.com/journals/jama/fullarticle/198993Begot I, Peixoto TC, Gonzaga LR, et al. (2015). A home-based walking program improves erectile dysfunction in men with an acute myocardial infarction. American Journal of Cardiology.https://pubmed.ncbi.nlm.nih.gov/25727080/Maio G, Saraeb S, Marchiori A. (2010). Physical activity combined with PDE5 inhibitor therapy improves erectile function more than medication alone.https://pubmed.ncbi.nlm.nih.gov/20367777/Bacon CG, Mittleman MA, Kawachi I, Giovannucci E, Glasser DB, Rimm EB. (2006). A prospective study of risk factors for erectile dysfunction. Journal of Urology.https://pubmed.ncbi.nlm.nih.gov/16753404/Feldman HA, Goldstein I, Hatzichristou DG, Krane RJ, McKinlay JB. (2000). Impotence and its medical and psychosocial correlates: Results of the Massachusetts Male Aging Study. Journal of Urology.https://pubmed.ncbi.nlm.nih.gov/10731462/Dorey G, Speakman M, Feneley R, Swinkels A, Dunn C. (2004). Randomized controlled trial of pelvic floor muscle exercises and biofeedback for erectile dysfunction. BJU International.https://pubmed.ncbi.nlm.nih.gov/15527607/Chen Z, et al. (2024). Effect of different physical activities on erectile dysfunction: A systematic review and network meta-analysis. Andrology.https://onlinelibrary.wiley.com/doi/full/10.1111/andr.13682

Description:  Hosts Roz and Dr. Sanchez-Fueyo discuss the key articles of the July issue of the American Journal of Transplantation. [3:52] Simultaneous quantification of native human and transgenic porcine liver function in a decedent model of extracorporeal cross-circulation [12:11] Pathologic evaluation of pig kidney and heart xenografts: 2024 recommendations from the Banff Xenotransplantation Pathology Working Group [13:36] The use of a centralized normothermic preservation and assessment center to rescue kidneys declined after standard allocation [25:57] Machine perfusion modulates cold-preservation injury in kidney transplantation: IDEAL stage 4 United States population cohort study [37:05] Impaired thymic function is independently associated with an increased risk of posttransplant infections in kidney recipients

In 2018, the ARIVE trial was published in the NEJM revealingthat induction of labor at 39 weeks reduced cesarean deliveries and gestational hypertension/preeclampsia in low-risk nulliparous women who had labor induced,compared to expectant management. Then, in 2025, and partly in response to L&D units across the country becoming saturated with low- risk, nulliparous patients awaiting their induction of labors at 39 weeks and 0 days, the ACOGreleased its clinical practice update in Jan 2025 stating, “The optimal timing of delivery for full-term pregnancies (39 0/7 to 40 6/7 weeks of gestation has not been determined”. Now there is new data, released as an article in press(June 26, 2026), out of the AJOG that raises some interesting questions about potential benefits of induction of labor LATER in the “full term” interval (40- 40 and 6 days) compared to earlier full term (39 weeks to 39 weeks 6 days). Thesefindings are “hypothesis- generating”.  Listen in for details. Strong Coffee Company - Protein Coffee PLUS MORE; Get 20%OFF | Promo Code: CHAPANOSPINOBG https://promocode.to/strong-coffee-company/chapanospinobg-hbv​     Grobman WA, Rice MM, Reddy UM, Tita ATN, et al;Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentMaternal–Fetal Medicine Units Network. Labor Induction versus ExpectantManagement in Low-Risk Nulliparous Women. N Engl J Med. 2018 Aug9;379(6):513-523. ​     Damri NT, Sheiner E, Wainstock T, GestationalAge at Full-Term Delivery and Long-Term Offspring Morbidity in Low-RiskPregnancies: A Population-Based Cohort Study, American Journal of Obstetricsand Gynecology (2026), ​     Management of Full-Term Nulliparous IndividualsWithout a Medical Indication for Delivery: ACOG Clinical Practice Update.Obstet Gynecol. 2025 Jan 1;145(1):e45-e50. doi: 10.1097/AOG.0000000000005783.Epub 2024 Nov 7. PMID: 39513607.

The FiltrateJoel Topf kidneyboy.bsky.socialSwapnil Hiremath @hswapnil.medsky.social Pedro Teixeira @nephcrit.bsky.socialSpecial GuestsEwout J. Hoorn, Professor of Medicine Erasmus MC, Netherlands. One of the primary authors.Harish Seethapathy, Assistant physician at Massachusetts General HospitalEditingVipin VergheseThe Kidney Connection written and performed by Timothy YauShow Notes A Randomized Trial of Targeted Hyponatremia Correction in Hospitalized Patients in NEJM Evidence, in PubMed, in NephJCSeethapathy: Severe Hyponatremia Correction, Mortality, and Central Pontine Myelinolysis in NEJM EvidenceMacMillan: Osmotic Demyelination Syndrome in Patients Hospitalized with Hyponatremia in NEJM EvidenceSALSA: Risk of Overcorrection in Rapid Intermittent Bolus vs Slow Continuous Infusion Therapies of Hypertonic Saline for Patients With Symptomatic Hyponatremia: The SALSA Randomized Clinical Trial in JAMA Internal MedicineSALT 1 and 2: Tolvaptan, a Selective Oral Vasopressin V2-Receptor Antagonist, for Hyponatremia in NEJM Hyponatremia registry: Current treatment practice and outcomes. Report of the hyponatremia registry in Kidney InternationalThe Richard Sterns' article on the lower mortality with more severe hyponatremia: Mortality and Serum Sodium: Do Patients Die from or with Hyponatremia? in CJASNThe European Hyponatremia Guidelines: Clinical practice guideline on diagnosis and treatment of hyponatraemia in The European Journal of EndocrinologyThe American Hyponatremia Guidelines: Diagnosis, Evaluation, and Treatment of Hyponatremia: Expert Panel Recommendations in American Journal of MedicineTreating hyponatremia: damned if we do and damned if we don't by Tom Berl in Kidney InternationalProspective (clamp) versus reactive (rescue) DDAVP in hyponatremia: Safety and efficacy of proactive versus reactive administration of desmopressin in severe symptomatic hyponatremia: a randomized controlled trial in Nature Scientific Reports and as covered in PBFluidsHelbert Rondon's RCT of urea Urea for Chronic Hyponatremia on ClinicalTrials.govTubular SecretionsSwapnil: Catfishing on CatNet: A Novel by Naomi Kritzer (Amazon)Harish: Disney CruiseEdward: Flesh: A Novel (Booker Prize Winner) by David Szalay (Amazon)Pedro: Scrubs reboot (IMDB)Joel: KIDNEYcon

About this episode:   Individuals awaiting organ transplants are often encouraged to reach out to family, friends, neighbors, and colleagues to ask if they will consider becoming a living organ donor. As social media expands our reach beyond our immediate communities, it could become a powerful tool in connecting recipients with donors. In this episode: Macey Levan, a kidney donor and researcher, explains why social media can be so useful in forging life-saving connections and what to consider when making the ask of an online community.  Guest:  Macey Levan, PhD, JD, is an associate professor of surgery and population health at NYU Grossman School of Medicine. She also serves as director of policy and external affairs for the Transplant Institute and director of the qualitative core in the Center for Surgical and Transplant Applied Research.  Host:  Stephanie Desmon, MA, is a former journalist, author, and the director of public relations and communications for the Johns Hopkins Center for Communication Programs.  Show links and related content:  Social Media in the Identification of Living Kidney Donors: Platforms, Tools, and Strategies—Current Transplantation Reports  Social media and organ donation: Ethically navigating the next frontier—American Journal of Transplantation  Kidney Donation: How to Make the Ask—National Kidney Foundation  Transcript information: Looking for episode transcripts? Open our podcast on the Apple Podcasts app (desktop or mobile) or the Spotify mobile app to access an auto-generated transcript of any episode. Closed captioning is also available for every episode on our YouTube channel. Contact us: Have a question about something you heard? Looking for a transcript? Want to suggest a topic or guest? Contact us via email or visit our website. Follow us: @‌PublicHealthPod on Bluesky @‌PublicHealthPod on Instagram @‌JohnsHopkinsSPH on Facebook @‌PublicHealthOnCall on YouTube Here's our RSS feed Note: These podcasts are a conversation between the participants, and do not represent the position of Johns Hopkins University.

This DermSurgery Digest bonus content aptly named “At the Microscope” shares the latest research and techniques in dermatopathology. In this episode, contributors review the histology of sebaceous carcinoma. Contributors to this podcast include Naomi Lawrence, MD, Dermatologic Surgery Digital Content Editor; Ashley Elsensohn, MD, MPH, DermSurgery Digest at the Microscope co-host; Christine Ahn, MD; Jeff Gardner, MD; Marina K. Ibraheim, MD; and Michael P. Lee, MD.Articles featured in this episode include: ·        “Role of immunohistochemistry in the diagnosis of sebaceous carcinoma: a clinicopathologic and immunohistochemical study” The American Journal of Dermatopahology·        “Squared-Off Nuclei and "Appliqué" Pattern as a Histopathological Clue to Periocular Sebaceous Carcinoma: A Clinicopathological Study of 50 Neoplasms From 46 Patients” The American Journal of Dermatopahology·        “Cytologic Grading of Cutaneous Sebaceous Neoplasms: Does it Help to Differentiate Benign From Malignant?” The American Journal of Dermatopahology·        “Two histopathologic patterns of well-differentiated extraocular sebaceous carcinoma” Journal of Cutaneous Pathology Your feedback is encouraged. Please contact communicationstaff@asds.net.

Many women are prescribed oral estrogen without ever being told what happens after it enters the body. In this episode, Dr. Brendan McCarthy takes a deeper look at estrone, the estrogen metabolite created when estradiol is taken orally, and explains why the delivery method of hormone therapy matters. You'll learn: The difference between estradiol and estrone Why oral estrogen creates significantly higher estrone levels How estrone may contribute to inflammation and insulin resistance The connection between estrogen metabolism and weight gain during perimenopause and menopause Why monitoring labs is essential when using hormone therapy The importance of understanding risks, benefits, and treatment options before starting hormones Dr. McCarthy also discusses the role of inflammation, body fat, metabolic health, and hormone delivery systems in creating long-term outcomes for women navigating menopause. This episode is about education, informed consent, and helping women better understand the science behind their care.   Citations: There is more than one estrogen; after menopause, estrone dominates Kuhl, Herbert. “Pharmacology of Estrogens and Progestogens: Influence of Different Routes of Administration.” Climacteric, vol. 8, no. S1, 2005, pp. 3–63. Body fat is an endocrine organ — aromatase converts androstenedione into estrone, and adipose becomes the dominant post-menopausal estrogen source Lee, Angel A., and Laura J. Den Hartigh. “Metabolic Impact of Endogenously Produced Estrogens by Adipose Tissue in Females and Males across the Lifespan.” Frontiers in Endocrinology, vol. 16, 2025, article 1682231. Inflamed fat raises IL-6; IL-6 tracks the insulin-resistant state Kern, Philip A., et al. “Adipose Tissue Tumor Necrosis Factor and Interleukin-6 Expression in Human Obesity and Insulin Resistance.” American Journal of Physiology-Endocrinology and Metabolism, vol. 280, no. 5, 2001, pp. E745–E751. IL-6 is part of the insulin-resistance machinery — it correlates with impaired insulin-stimulated glucose uptake Bastard, Jean-Philippe, et al. “Adipose Tissue IL-6 Content Correlates with Resistance to Insulin Activation of Glucose Uptake Both In Vivo and In Vitro.” The Journal of Clinical Endocrinology & Metabolism, vol. 87, no. 5, 2002, pp. 2084–2089. Inflammation amplifies aromatase — IL-6 raises aromatase via COX-2/PGE2 Bowers, Laura W., et al. “Obesity-Associated Systemic Interleukin-6 Promotes Pre-Adipocyte Aromatase Expression via Increased Breast Cancer Cell Prostaglandin E2 Production.” Breast Cancer Research and Treatment, vol. 149, no. 1, 2015, pp. 49–57. Human-tissue confirmation: HOMA-IR, IL-6, insulin, leptin, hsCRP track breast aromatase after menopause Brown, Kristy A., et al. “Menopause Is a Determinant of Breast Aromatase Expression and Its Associations with BMI, Inflammation, and Systemic Markers.” The Journal of Clinical Endocrinology & Metabolism, vol. 102, no. 5, 2017, pp. 1692–1701. Iyengar, Neil M., et al. “Effects of Obesity on Breast Aromatase Expression and Systemic Metabo-Inflammation in Women with BRCA1 or BRCA2 Mutations.” npj Breast Cancer, vol. 7, no. 1, 2021, article 18. The molecular crux: estrone drives ERα/NF-κB inflammatory signaling while estradiol opposes it Qureshi, Rehana, et al. “The Major Pre- and Postmenopausal Estrogens Play Opposing Roles in Obesity-Driven Mammary Inflammation and Breast Cancer Development.” Cell Metabolism, vol. 31, no. 6, 2020, pp. 1154–1172.e9. Estrone as a metabolic-risk signal — prospectively associated with diabetes (note: male cohort) Jasuja, Guneet Kaur, et al. “Circulating Estrone Levels Are Associated Prospectively with Diabetes Risk in Men of the Framingham Heart Study.” Diabetes Care, vol. 36, no. 9, 2013, pp. 2591–2596.   Dr. Brendan McCarthy is the founder and Chief Medical Officer of Protea Medical Center in Arizona. With over two decades of experience, he's helped thousands of patients navigate hormonal imbalances using bioidentical HRT, nutrition, and root-cause medicine. He's also taught and mentored other physicians on integrative approaches to hormone therapy, weight loss, fertility, and more. If you're ready to take your health seriously, this podcast is a great place to start.

We often hear that if you love what you do, you'll never work a day in your life. But for some, loving what they do at work seems impossible. What if we could find meaning and connection in our work, no matter our circumstances? How would that change the way we viewed work?In this episode, we're joined by Dr. Jessica Grossmeier, researcher and author of Well at Work and Reimagining Workplace Well-being, to discuss how we can find meaning and purpose within work.Episode Links:Dr. Grossmeier's books:Well at Work: https://www.amazon.com/Well-At-Work-Connection-Transcendence/dp/B0FHNKJ277Reimagining Workplace Well-being: https://www.amazon.com/Reimagining-Workplace-Well-being-Connection-Transcendence/dp/1951692195Follow Dr. Grossmeier on LinkedIn: https://www.linkedin.com/in/jgrossmeier/Learn more about Dr. Grossmeier's services:https://www.jessicagrossmeier.com/About Dr. Jessica GrossmeierJessica Grossmeier, PhD, MPH is an award-winning researcher, speaker, and author of “Reimagining Workplace Well-being: Fostering a Culture of Purpose, Connection, and Transcendence” and “Well At Work: Chart Your Course to Purpose, Connection, and Transcendence.” She is a leading voice in workplace well-being and was recently recognized as one of the most influential women leaders in health promotion by the American Journal of Health Promotion.About Propel:Propel is the purpose-built well-being platform designed to help you develop a culture of well-being and bring your vision to life. Propel helps you launch a truly engaging program with flexible technology that tailors the experience to your diverse teams.Create a unique well-being experience from within. See how Propel can help by scheduling a free strategy session at propelwellbeing.com.

The story of the Roman catacombs is vastly different than that of the catacombs of Paris, as Rome’s are much older and were created for very different reasons. Research: Bonello, Giovanni. “Charting the enigmatic life of Antonio Bosio.” Times of Malta. Dec. 6, 2014. https://timesofmalta.com/article/Charting-the-enigmatic-life-of-Antonio-Bosio.547468 Bonello, Giovanni. “How Antonio Bosio Became famous Worldwide.” Times of Malta. Dec. 13, 2014. https://timesofmalta.com/article/How-Antonio-Bosio-became-famous-worldwide.548393 Bosio, Antonio. “Roma sotteranea.” 1650. Accessed online: https://books.google.com/books?id=zCXXSKqq3nQC&printsec=frontcover&source=gbs_atb#v=onepage&q&f=false Britannica Editors. "Edict of Milan". Encyclopedia Britannica, 8 Aug. 2019, https://www.britannica.com/topic/Edict-of-Milan Britannica Editors. "First Jewish Revolt". Encyclopedia Britannica, 31 Mar. 2025, https://www.britannica.com/event/First-Jewish-Revolt Britannica Editors. "Law of the Twelve Tables". Encyclopedia Britannica, 29 Mar. 2018, https://www.britannica.com/topic/Law-of-the-Twelve-Tables “The Catacombs of Rome.” The Atlantic Monthly. March 1858. https://www.theatlantic.com/magazine/archive/1858/03/the-catacombs-of-rome/627225/ Coleman-Norton, Paul R. “The Twelve Tables.” 2024 (eBook). https://www.gutenberg.org/cache/epub/14783/pg14783-images.html “Diocletianic Persecution.” Ebsco. 2023. https://www.ebsco.com/research-starters/religion-and-philosophy/diocletianic-persecution “Jews in Roman Times.” The Roman Empire. PBS. https://www.pbs.org/empires/romans/empire/jews.html Lamberton, Clark D. “The Development of Christian Symbolism as Illustrated in Roman Catacomb Painting.” American Journal of Archaeology, vol. 15, no. 4, 1911, pp. 507–22. JSTOR, https://doi.org/10.2307/497187 Munro, Dana Carleton et al. “Translations and reprints from the original sources of European history : series for 1897.” University of Pennsylvania. 1898. https://archive.org/details/translationsrepr00munr/page/n3/mode/2up Northcote, James Spencer. “The Roman Catacombs.” Sophia Institute Press. 2017. (Reprint) Northcote, James Spencer. ““The Roman Catacombs; or Some Accounts of the Burial Places of the Early Christians in Rome.” Philadelphia. Peter F. Cunningham. 1857. (Reprint) Osborne, J. “The Roman Catacombs in the Middle Ages.” Papers of the British School at Rome , 1985, Vol. 53 (1985), pp. 278-328. https://www.jstor.org/stable/40310821 Perrottet, Tony. “Explore Rome’s Hidden Underworld, Where a City Lurks Beneath a City.” Smithsonian. April/May 2025. https://www.smithsonianmag.com/travel/explore-romes-hidden-underworld-city-beneath-city-180986228/ “PONTIFICAL COMMISSION FOR SACRED ARCHAEOLOGY – Historical Notes.” Vatican. https://www.vatican.va/roman_curia/pontifical_commissions/archeo/inglese/documents/rc_com_archeo_doc_20011010_cenni_en.html Richter, J. P. “Early Christian Art in the Roman Catacombs.” The Burlington Magazine for Connoisseurs, vol. 6, no. 22, 1905, pp. 286–262. JSTOR, http://www.jstor.org/stable/856226 “The Roman Catacombs.” Architecture. April 20, 1888. No. 414, p. 224. https://babel.hathitrust.org/cgi/pt?id=nyp.33433084078983&seq=414&q1=catacombs “The Roman Catacombs.” Scientific American, vol. 58, no. 20, 1888, pp. 312–312. JSTOR, http://www.jstor.org/stable/26094597 Rossi, Giovannie Battista de, et all. “Roma sotterranea : or, Some account of the Roman catacombs, especially of the cemetery of San Callisto ; comp. from the works of Commendatore de Rossi with the consent of the author.” Longmans, Green, Reader and Dyer. London. 1869. https://archive.org/details/a606740800rossuoft/a606740800rossuoft/page/6/mode/2up RUTGERS, LEONARD VICTOR, and לאונרד רוטגרס. “הקטקומבות היהודיות ברומא: הערכה מחודשת / THE JEWISH CATACOMBS OF ROME RECONSIDERED.” Proceedings of the World Congress of Jewish Studies / דברי הקונגרס העולמי למדעי היהדות, י, 1989, pp. 29–36. JSTOR, http://www.jstor.org/stable/23535611 Terry, Andrea, and John Osborne. “Un Canadien Errant: Charles Smeaton and the Earliest Photographs of the Roman Catacombs.” RACAR: Revue d’art Canadienne / Canadian Art Review, vol. 32, no. 1/2, 2007, pp. 94–106. JSTOR, http://www.jstor.org/stable/42630755 Yeomans, Sarah. “City of the Dead.” Archaeology, vol. 61, no. 4, 2008, pp. 55–62. JSTOR, http://www.jstor.org/stable/41780388 See omnystudio.com/listener for privacy information.

Credits: 0.25 AMA PRA Category 1 Credit™   CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-490 Overview: In the US, maternal morbidity and mortality rates are among the highest in the western world, and stroke is one of the leading causes—responsible for 1 of 12 maternal deaths. This rate is estimated to be much higher in high-risk pregnancies. Join us as we discuss a recent study examining rates of maternal stroke in which 1 in 4 women with stroke experienced a missed diagnostic opportunity and hear what these findings mean for your practice. Episode resource links: Haghighi N, Bourscheid RM, Shang C, et al. Identifying missed diagnostic opportunities in maternal stroke. Stroke. 2026;57(2). doi:10.1161/STROKEAHA.125.052995 Chen Y, Shiels MS, Uribe-Leitz T, et al. 2025. Pregnancy-Related Deaths in the US, 2018-2022. JAMA Network Open.  Lappen JR, Pettker CM, Louis JM. 2021. American Journal of Obstetrics and Gynecology. Society for Maternal-Fetal Medicine Consult Series #54: Assessing the Risk of Maternal morbidity and Mortality. American Journal of Obstetrics and Gynecology. Miller EC, Bello NA, Chen PR, et al 2026. Prevention and Treatment of Maternal Stroke in Pregnancy and Postpartum: A Scientific Statement from the American Heart Association. Stroke.  Bushnell C, Kernan WN, Sharrief AZ, et al. 2024. Guideline for the Primary Prevention of Stroke: A Guideline from the American Heart Association/¬American Stroke Association. Stroke.  Guest: Susan Feeney, DNP, FNP-BC, NP-C   Music Credit: Matthew Bugos Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com  The views expressed in this podcast are those of Dr. Domino and his guests and do not necessarily reflect the views of Pri-Med.

Links For The Occult Rejectshttps://linktr.ee/theoccultrejectsOccult Research Institutehttps://www.occultresearchinstitute.org/Substackhttps://substack.com/@theoccultrejects?r=7auau0&utm_campaign=profile&utm_medium=profile-pageCash Apphttps://cash.app/$theoccultrejectsVenmo@TheOccultRejectsBuy Me A Coffeebuymeacoffee.com/TheOccultRejectsPatreonhttps://www.patreon.com/TheOccultRejectsPart 1 focuses on the drum as an ancient technology of altered consciousness. The argument is not that every beat causes trance, or that neuroscience has proven spirits. The stronger argument is that rhythm enters the human organism through hearing, motor prediction, breath, movement, attention, emotion, expectation, culture, and social synchrony. The drum becomes powerful when sound, body, group, ritual frame, and meaning converge. These sources support the archaeology, neuroscience, EEG research, shamanic studies, possession studies, Indigenous and culturally specific drum traditions, ritual theory, placebo and meaning-response research, ceremonial magic, and modern witchcraft material used in the episode.Core Academic and Scientific SourcesHuels, Emma R., Hyoungkyu Kim, UnCheol Lee, Tirsa Bel-Bahar, Ana V. Colmenero, Alexandra Nelson, Stefanie Blain-Moraes, George A. Mashour, and Richard E. Harris. “Neural Correlates of the Shamanic State of Consciousness.” Frontiers in Human Neuroscience 15 (2021): 610466.Gordon, Yoel, Golan Karvat, Noa Dagan, and Ayelet N. Landau. “Neural Tracking at Theta Predicts Drumming-Induced Altered States of Consciousness.” Scientific Reports 16, no. 1 (2026): Article 10204.Aparicio-Terrés, R., et al. “The Neurobiology of Altered States of Consciousness Induced by Drumming and Other Rhythmic Sound Patterns.” Annals of the New York Academy of Sciences, 2025.Neher, Andrew. “Auditory Driving Observed with Scalp Electrodes in Normal Subjects.” Electroencephalography and Clinical Neurophysiology 13 (1961): 449–451.Neher, Andrew. “A Physiological Explanation of Unusual Behavior in Ceremonies Involving Drums.” Human Biology 34, no. 2 (1962): 151–160.Maurer, R., V. K. Kumar, L. Woodside, and R. J. Pekala. “Phenomenological Experience in Response to Monotonous Drumming and Hypnotizability.” American Journal of Clinical Hypnosis 40, no. 2 (1997): 130–145. Use for monotonous drumming, subjective altered experience, imagery, absorption, and hypnotizability.Maxfield, Melinda C. “Effects of Rhythmic Drumming on EEG and Subjective Experience.” PhD diss., Institute of Transpersonal Psychology, 1990. Use as older supporting context on drumming, EEG, imagery, body-image changes, and subjective altered experience. Do not make this the main scientific proof; use it as background.Nozaradan, Sylvie, Isabelle Peretz, and André Mouraux. “Tagging the Neuronal Entrainment to Beat and Meter.” The Journal of Neuroscience 31, no. 28 (2011): 10234–10240. Use for EEG evidence that the brain can track beat and meter. This supports the claim that the brain does not merely hear rhythm as background sound; it can represent rhythmic structure in measurable ways.Nozaradan, Sylvie. “Exploring How Musical Rhythm Entrains Brain Activity with Electroencephalogram Frequency-Tagging.” Philosophical Transactions of the Royal Society B 369, no. 1658 (2014). Use as broader rhythm/EEG entrainment support. This helps explain frequency-tagging, beat tracking, meter, neural entrainment, and the measurable relationship between rhythmic structure and brain activity.Thaut, Michael H., Gerald C. McIntosh, and Volker Hoemberg. “Neurobiological Foundations of Neurologic Music Therapy: Rhythmic Entrainment and the Motor System.” Frontiers in Psychology 5 (2015). Use for rhythm as motor-system timing information. This supports the claim that a beat can become bodily instruction, not just sound for the ear. Especially useful when discussing rhythmic auditory stimulation, motor planning, gait, entrainment, and the auditory-motor bridge.Ross, Jessica M., John R. Iversen, and Ramesh Balasubramaniam. “Time Perception for Musical Rhythms: Sensorimotor Perspectives on Entrainment, Simulation, and Prediction.” 2022. Use for rhythm, timing, prediction, sensorimotor entrainment, and the way musical rhythm interacts with time perception.Hove, Michael J., and Jane L. Risen. “It's All in the Timing: Interpersonal Synchrony Increases Affiliation.” Social Cognition 27, no. 6 (2009): 949–960. Use for synchrony and social bonding. This helps support the group-body argument: moving or acting in time with others can increase affiliation.Wiltermuth, Scott S., and Chip Heath. “Synchrony and Cooperation.” Psychological Science 20, no. 1 (2009): 1–5. Use for the claim that synchronized movement can increase cooperation and attachment among participants.Tarr, Bronwyn, Jacques Launay, and Robin I. M. Dunbar. “Music and Social Bonding: ‘Self-Other' Merging and Neurohormonal Mechanisms.” Frontiers in Psychology 5 (2014): 1096. Use for music, synchrony, bonding, endorphin/social mechanisms, and why group rhythm can feel like more than private listening.Fancourt, Daisy, Rosie Perkins, Sara Ascenso, Louise Atkins, Fatima Kilfeather, and Aaron Williamon. “Effects of Group Drumming Interventions on Anxiety, Depression, Social Resilience and Inflammatory Immune Response among Mental Health Service Users.” PLOS ONE 11, no. 3 (2016): e0151136. Use for modern group-drumming research showing psychological and physiological effects, including anxiety, depression, social resilience, wellbeing, and inflammatory immune response. Use carefully: this does not make group drumming a cure-all. It supports the more grounded claim that embodied rhythm and group participation can affect mood, social connection, and body chemistry.Bittman, Barry B., et al. “Composite Effects of Group Drumming Music Therapy on Modulation of Neuroendocrine-Immune Parameters in Normal Subjects.” Alternative Therapies in Health and Medicine 7, no. 1 (2001): 38–47. Use as older supporting material on group drumming and neuroendocrine-immune measures. Keep secondary. Fancourt is cleaner for the main script body.Archaeology and Deep History of DrumsLawergren, Bo. “Neolithic Drums in China.” In Music Archaeology in China. 2006. Use for clay drums in Neolithic China and the deep-history claim that drums are not just poetic symbols of antiquity. They appear in the archaeological record as instruments tied to early sound-making, ceremony, and social order.Both, Arnd Adje. “Music Archaeology: Some Methodological and Theoretical Considerations.” Use as general support for why ancient instruments should be treated as ritual and social evidence, not merely decorative objects.Anthropology, Ethnomusicology, Ritual, and TranceRouget, Gilbert. Music and Trance: A Theory of the Relations Between Music and Possession. Translated by Brunhilde Biebuyck. Chicago: University of Chicago Press, 1985. Essential source. Use for the caution that music does not mechanically or universally cause trance. Rouget helps keep the argument academically serious by emphasizing culture, ritual frame, meaning, and expectation.Becker, Judith. Deep Listeners: Music, Emotion, and Trancing. Bloomington: Indiana University Press, 2004. Use for music-linked trancing, emotional absorption, religious experience, and culturally trained ways of listening. This supports the “hearing versus entering” distinction.McNeill, William H. Keeping Together in Time: Dance and Drill in Human History. Cambridge, MA: Harvard University Press, 1995. Use for marching, dance, drill, muscular bonding, synchronized movement, and rhythm as social glue. This is useful both for Part 1's group-body material and Part 2's war-drum material.Eliade, Mircea. Shamanism: Archaic Techniques of Ecstasy. Princeton: Princeton University Press, 1964. Use carefully. Eliade's phrase “archaic techniques of ecstasy” is powerful, but the episode should also note that later scholarship criticizes his tendency to universalize shamanism.Winkelman, Michael. Shamanism: A Biopsychosocial Paradigm of Consciousness and Healing. 2nd ed. Santa Barbara, CA: Praeger, 2010. Use for shamanism as a ritual technology involving altered consciousness, healing, social integration, symbolism, and body-brain processes.Winkelman, Michael. “Shamanism and Psychedelics: A Biogenetic Structuralist Paradigm of Ecopsychology.” European Journal of Ecopsychology 4 (2013): 90–115. Use as supplemental background on shamanism, altered consciousness, and comparative models of trance and visionary states.Kontouli, Athanasia, Michael J. Hove, Alexandre Lehmann, Peter Vuust, and Peter E. Keller. “The Rhythms of Trance: Cultural Phenomenology and Neural Mechanisms of Music-Induced Lewis-Williams, David. The Mind in the Cave: Consciousness and the Origins of Art. London: Thames & Hudson, 2002. Use cautiously for altered states, entoptic imagery, ritual vision, and the relationship between neuropsychology and symbolic culture.Non-Ordinary States of Consciousness.” Neuroscience & Biobehavioral Reviews, 2026. Use for the bridge between cultural phenomenology and neuroscience. This supports the point that music-induced trance is not only acoustics; it involves body, training, expectation, culture, environment, and interpretation.Tart, Charles T., ed. Altered States of Consciousness. New York: Wiley, 1969. Use as classic altered-state background.Hultkrantz, Åke. “The Drum in Shamanism.” Use for classic comparative material on the shamanic drum, especially Arctic, SiberiAlso want to remind people about the website, if you're into reading we have tons of information by multiple contributors, and we got t-shirts up on the site if you're interested. Fun fact, the art is all based on the eyeball. A

Credits: 0.25 AMA PRA Category 1 Credit™   CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-490 Overview: In the US, maternal morbidity and mortality rates are among the highest in the western world, and stroke is one of the leading causes—responsible for 1 of 12 maternal deaths. This rate is estimated to be much higher in high-risk pregnancies. Join us as we discuss a recent study examining rates of maternal stroke in which 1 in 4 women with stroke experienced a missed diagnostic opportunity and hear what these findings mean for your practice. Episode resource links: Haghighi N, Bourscheid RM, Shang C, et al. Identifying missed diagnostic opportunities in maternal stroke. Stroke. 2026;57(2). doi:10.1161/STROKEAHA.125.052995 Chen Y, Shiels MS, Uribe-Leitz T, et al. 2025. Pregnancy-Related Deaths in the US, 2018-2022. JAMA Network Open.  Lappen JR, Pettker CM, Louis JM. 2021. American Journal of Obstetrics and Gynecology. Society for Maternal-Fetal Medicine Consult Series #54: Assessing the Risk of Maternal morbidity and Mortality. American Journal of Obstetrics and Gynecology. Miller EC, Bello NA, Chen PR, et al 2026. Prevention and Treatment of Maternal Stroke in Pregnancy and Postpartum: A Scientific Statement from the American Heart Association. Stroke.  Bushnell C, Kernan WN, Sharrief AZ, et al. 2024. Guideline for the Primary Prevention of Stroke: A Guideline from the American Heart Association/¬American Stroke Association. Stroke.  Guest: Susan Feeney, DNP, FNP-BC, NP-C   Music Credit: Matthew Bugos Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com  The views expressed in this podcast are those of Dr. Domino and his guests and do not necessarily reflect the views of Pri-Med.

Tu souffres de fatigue chronique, de maladies auto-immunes, de douleurs diffuses, de troubles digestifs ou d'anxiété que personne n'arrive vraiment à expliquer ? Il est possible que la réponse soit dans ton histoire et dans la façon dont ton corps s'y est adapté.Dans cet épisode, on explore le lien — documenté, biologique, cellulaire — entre les traumatismes vécus dans l'enfance, la réponse de figement du système nerveux, et les maladies chroniques qui peuvent apparaître des années, voire des décennies plus tard.Ce n'est pas une théorie. C'est de la physiologie. Et comprendre ce mécanisme peut changer profondément la façon dont tu te regardes — et dont tu prends soin de toi.

When “Jaws” hit theatres in 1975, no one—neither the studio executives involved nor the film's twenty-six-year-old director, Steven Spielberg—was betting on its success. But it dominated at the box office and promptly revolutionized the way movies were promoted, distributed, and merchandised. On this episode of Critics at Large, Vinson Cunningham, Naomi Fry, and Alexandra Schwartz trace how Spielberg inaugurated a new phenomenon in Hollywood: the blockbuster. He would tap his own playbook again and again with such hits as “Close Encounters of the Third Kind,” “E.T.,” and “Jurassic Park,” all of which drew impressive audiences and profits. The hosts talk through his filmography, culminating in his new release, “Disclosure Day,” which both replicates and iterates on themes and techniques found in his earlier work. Though other directors may share his capacity for spectacle and action-packed set pieces, much of his appeal lies in his profound earnestness. “What Spielberg is so good at is bringing the human to the fore in these extreme, sci-fi circumstances,” Schwartz says. “And that's what makes a great blockbuster.”Read, watch, and listen with the critics:“Jaws” (1975)“Disclosure Day” (2026)“Minority Report” (2002)“Oscar Wars,” by Michael Schulman“What Went Wrong” 's episode about “Jaws”“Close Encounters of the Third Kind” (1977)“Jurassic Park” (1993)“E.T.” (1982)“Alf” (1986-90)“Schindler's List” (1993)“One Battle After Another” (2025)“American Journal,” by Robert Hayden“Heart of the Beast” (2026)“Sinners” (2025)“Nope” (2022)“Barbie” (2023)“Obsession” (2026)“Backrooms” (2026)New episodes drop every Thursday. Follow Critics at Large wherever you get your podcasts.Critics at Large is a weekly discussion from The New Yorker which explores the latest trends in books, television, film, and more. Join us every Thursday as we make unexpected connections between classic texts and pop culture. Learn about your ad choices: dovetail.prx.org/ad-choices

In this Supplement Ingredients episode, Nurse Doza breaks down phosphatidylcholine—one of his all-time favorite supplements for your liver and brain. He explains why medications and aging deplete your choline, how phosphatidylcholine delivers fast energy, focus, and mental clarity without stimulants or a crash, and why he finally landed on BodyBio after years of testing. If liver issues or cognitive decline are on your radar, this one's a must-listen. FEATURED PARTNER: BODYBIO BodyBio Phosphatidylcholine (PC) delivers clean, bioavailable phospholipids that rebuild your cell membranes—supporting the liver and brain function discussed in this episode—with a noticeable "crisp" clarity you can feel in about an hour, no jitters and no crash.

Send us Fan MailThe Quiet Power of Legumes.What if the secret to a longer, healthier life isn't trendy, expensive, or Instagram-worthy — it's sitting in a can in your pantry right now? Today, I break down why legumes show up again and again in the diets of the world's longest-living people, and how to add them to your plate without overhauling your life.Calls to Action•       Rate and subscribe to Project Weight Loss•       Share this episode with someone who needs a gentle nudge toward sustainable habits•       Try one of the three legume swaps this week and tag the showCitations & SourcesDarmadi-Blackberry, I., Wahlqvist, M. L., Kouris-Blazos, A., Steen, B., Lukito, W., Horie, Y., & Horie, K. (2004). Legumes: the most important dietary predictor of survival in older people of different ethnicities. Asia Pacific Journal of Clinical Nutrition, 13(2), 217–220.Buettner, D., & Skemp, S. (2016). Blue Zones: Lessons From the World's Longest Lived. American Journal of Lifestyle Medicine, 10(5), 318–321.Stanley, E. (Lord Derby). "Those who think they have no time for healthy eating will sooner or later have to find time for illness." (Widely attributed quote, often cited in health and wellness literature.)DisclaimerThis podcast is for informational and educational purposes only and is not intended as medical advice. Listeners with specific health conditions or dietary needs should consult their healthcare provider or a registered dietitian.Let's go, let's get it done.Get more information at: http://projectweightloss.org

The FIFA World Cup and ACL injuries remain one of the most impactful injuries in professional soccer. While much of the discussion around ACL reconstruction focuses on graft choice, rehabilitation, and return-to-play timelines, a new study published in the American Journal of Sports Medicine highlights an often-overlooked challenge: secondary muscle injuries after athletes return to competition.In this episode of Overtime with The Sports Docs, Drs. Ashley Bassett and Catherine Logan review the newly published article, "Secondary Muscle Injuries and Performance Decline After Anterior Cruciate Ligament Reconstruction in Professional Soccer." The study examines the incidence, timing, and impact of muscle injuries following ACL reconstruction in elite soccer players and explores how these injuries affect performance, playing time, and even market value.The findings reinforce an important principle in sports medicine: return to play is not the finish line—it is only the next phase of recovery.Key Discussion PointsUnderstanding ACL Injuries in SoccerCommon mechanisms of ACL injury in soccerWhy cutting, pivoting, deceleration, and landing place soccer players at particularly high riskThe career implications of ACL injuries in professional athletesACL Reconstruction Graft OptionsBone-Patellar Tendon-Bone (BTB) autograftHamstring tendon autograftQuadriceps tendon autograftAdvantages and disadvantages of each graft choiceWhy allograft tissue is generally avoided in elite athletesModern Return-to-Play Decision MakingMoving beyond time-based return-to-play criteriaStrength testing and limb symmetryHop testing and movement analysisNeuromuscular control assessmentPsychological readiness for sportOngoing graft maturation and biologic healingStudy Review: Secondary Muscle Injuries After ACL ReconstructionThe authors evaluated professional male soccer players from Europe's top leagues who underwent ACL reconstruction between 2020 and 2023 and compared them with matched healthy controls.Key findings included:32.5% of ACL-reconstructed players sustained a secondary muscle injury within one year of return to playOnly 12.5% of matched controls experienced muscle injuriesACL-reconstructed athletes were more than twice as likely to sustain a muscle injury after returnMost Common Secondary InjuriesHamstring strains (42%)Quadriceps strains (32%)Calf injuries (16%)Adductor injuries (11%)Notably, nearly 70% of injuries occurred on the reconstructed side, suggesting persistent deficits may contribute to injury risk.The Highest-Risk WindowOne of the most important findings:Nearly 58% of all secondary muscle injuries occurred between 3 and 6 months after return to competitionThis period may represent a critical vulnerability window when athletes are increasing match exposure, training volume, and competition demands.The Importance of the 9-Month RuleThe strongest predictor of secondary muscle injury was early return to play:Athletes returning before 9 months after ACL reconstruction had nearly a fivefold increased risk of secondary muscle injuryThis study adds to the growing body of evidence supporting delayed, criteria-based return to sport rather than return based solely on time.Performance and Career ImpactPlayers who sustained secondary muscle injuries experienced:Reduced playing timeFewer minutes on the fieldDecreased participation metricsDeclines in overall performanceThe study also demonstrated significant reductions in player market value among athletes who experienced secondary injuries, highlighting the financial and career implications of incomplete recovery.Strengths and Limitations of the StudyStrengthsMatched-control designFocus on elite professional soccer playersInclusion of performance metrics and market value outcomesReal-world relevance for sports medicine clinicians and team physiciansLimitationsRetrospective study designRelatively small sample sizeNo objective rehabilitation data availableNo information on graft typeLack of strength testing, hop testing, or psychological readiness measuresNo workload or GPS tracking dataClinical TakeawaysACL recovery extends well beyond return to competition.Return to play should be viewed as a milestone, not the endpoint.The first 3–6 months after return may represent the highest-risk period for secondary injury.Continued strength training, neuromuscular training, and workload monitoring remain essential after athletes resume competition.Returning before 9 months after ACL reconstruction may substantially increase the risk of secondary muscle injury.Successful ACL recovery is not simply about returning to sport—it is about staying healthy and performing at a high level after return.Article Discussed"Secondary Muscle Injuries and Performance Decline After Anterior Cruciate Ligament Reconstruction in Professional Soccer"Published in the American Journal of Sports Medicine (AJSM), 2026.

Description:  Hosts Roz and Dr. Sanchez-Fueyo discuss the key articles of the June issue of the American Journal of Transplantation. [3:32] MHC Matchmaker: An in silico based algorithm to analyze cross-species NHP, pig, and human MHC compatibility on the amino acid level [11:50] Wisdom of the Crowd: Ensuring the justness and validity of group decision-making in solid organ transplant [16:39] Inhibition of cytomegalovirus reactivation by ex vivo treatment of human kidneys with the SYN002 immunotoxin [22:20] There is nothing equitable about a wasted organ; eliminating out-of-sequence allocation for 30 days decreases utilization of hard-to-place kidneys

What if one of the most powerful medicines for longevity, resilience, happiness, cognitive health, and disease prevention wasn't found in a supplement, a prescription, or a cutting-edge biohack—but in the people around you? In this powerful solo episode, Darin Olien dives into one of the most overlooked health crises of our time: loneliness. Drawing from the landmark 85-year Harvard Adult Development Study, the U.S. Surgeon General's loneliness epidemic report, Blue Zones research, neuroscience, and evolutionary biology, Darin reveals why meaningful human connection may be one of the strongest predictors of health and longevity ever discovered. From oxytocin, cortisol, inflammation, vagal tone, and nervous system regulation to suburban design, social media, and the collapse of community structures, Darin exposes the hidden biological costs of isolation—and offers a practical roadmap for rebuilding the human connections we were biologically designed to need.     What You'll Learn The stunning findings from Harvard's 85-year Adult Development Study Why relationships outperform wealth, genetics, diet, and exercise as predictors of well-being How loneliness increases the risk of premature death, dementia, heart disease, and stroke Why social isolation creates measurable biological stress responses The role of oxytocin in lowering inflammation and regulating stress How human connection affects the autonomic nervous system Why Blue Zone communities consistently prioritize social connection The biological difference between digital interaction and real human presence How modern architecture and technology contribute to loneliness Why community is a biological necessity—not a luxury Practical ways to rebuild meaningful relationships today How connection may be one of the most powerful health interventions available   Chapters 00:00:00 – Welcome to SuperLife 00:00:33 – Sponsor: Bite Toothpaste and reducing plastic waste 00:02:49 – The most powerful health study ever conducted 00:03:01 – Harvard follows 724 people for 85 years 00:03:40 – The surprising predictor of a long, healthy life 00:04:00 – Why relationships beat wealth, genetics, diet, and exercise 00:04:42 – The Surgeon General's loneliness epidemic warning 00:05:19 – Introducing the medicine you're not taking 00:05:53 – The health benefits of genuine community 00:06:21 – The fatal convenience of modern life 00:06:47 – Replacing human connection with digital connection 00:07:12 – Why modern convenience may be creating isolation 00:07:23 – Social isolation and premature mortality 00:08:02 – Loneliness and the equivalent of smoking 15 cigarettes a day 00:08:43 – Increased risks of heart disease, stroke, and dementia 00:09:10 – Why loneliness is a biological threat 00:09:52 – The science behind social isolation 00:10:11 – Sponsor: Manna Vitality 00:12:06 – Humans as the most socially dependent species 00:12:53 – Why connection regulates the nervous system 00:13:29 – The autonomic nervous system and social safety 00:13:56 – The brain's constant question: Am I safe? 00:14:03 – The biology of belonging 00:14:24 – The ventral vagal state explained 00:14:55 – Why connection creates measurable physiological changes 00:15:03 – What happens when isolation becomes chronic 00:15:52 – Oxytocin: far more than the "love hormone" 00:16:20 – Eye contact, touch, meals, and human bonding 00:16:42 – How oxytocin lowers stress and inflammation 00:17:04 – Why no supplement can replace connection 00:17:17 – The pharmacology of authentic human moments 00:18:06 – Free medicine hidden in plain sight 00:18:39 – Dan Buettner and the Blue Zones 00:19:29 – What the world's longest-lived populations have in common 00:19:36 – Okinawa's lifelong friendship circles 00:20:08 – Sardinia's active elders and social roles 00:20:40 – Greece's culture of connection and communal meals 00:21:03 – Why longevity wasn't hacked—it was lived 00:21:38 – Social connection as the foundation of daily life 00:22:01 – The shocking decline in face-to-face interaction 00:22:21 – Young people losing 70% of in-person social time 00:22:58 – How community was systematically dismantled 00:23:00 – Robert Putnam's Bowling Alone 00:23:49 – Doing life together versus doing life alone 00:24:05 – How suburban design creates isolation 00:24:49 – The built environment shapes human behavior 00:24:55 – Social media and the promise of connection 00:25:20 – Why digital connection fails biologically 00:25:33 – Social comparison, anxiety, and nervous system stress 00:25:49 – More connected online, more isolated in reality 00:26:03 – A call to action: treating relationships like health practices 00:27:00 – Practical ways to rebuild community 00:28:00 – Prioritizing people over convenience 00:29:00 – Deep conversations, presence, and intentional connection 00:30:00 – Reclaiming community in modern life 00:31:00 – Final thoughts on connection, belonging, and health 00:31:53 – Closing remarks and outro     Thank You to Our Sponsors Bite Toothpaste: Go to trybite.com/DARIN20 or use code DARIN20 for 20% off your first order Manna Vitality: Go to mannavitality.com/ and use code DARIN12 for 12% off your order.     Join the SuperLife Patreon: This is where Darin now shares the deeper work: - weekly voice notes - ingredient trackers - wellness challenges - extended conversations - community accountability - sovereignty practices Join now for only $7.49/month at https://patreon.com/darinolien     Find More from Darin Olien: Website: darinolien.com Instagram: @darinolien Book: Fatal Conveniences Platform & Products: superlife.com New Show: Roadmap to Happiness     Key Takeaway "The longest-running study in human history reached a conclusion that should fundamentally change how we think about health: the quality of our relationships predicts our happiness, resilience, and longevity more than almost anything else. Human connection isn't a luxury, a personality trait, or a nice bonus when life slows down. It is biology. It is medicine. And in a world increasingly designed for isolation, rebuilding community may be one of the most important health decisions we ever make."     Bibliography/Sources: Primary Research — Loneliness, Social Isolation & Health Associated Press. (2023, May 2). Surgeon general: Loneliness poses health risks as deadly as smoking. PBS NewsHour. https://www.pbs.org/newshour/health/surgeon-general-loneliness-poses-health-risks-as-deadly-as-smoking Cacioppo, J. T., & Hawkley, L. C. (2009). Perceived social isolation and cognition. Trends in Cognitive Sciences, 13(10), 447–454. https://doi.org/10.1016/j.tics.2009.06.005 Holt-Lunstad, J., Smith, T. B., & Layton, J. B. (2010). Social relationships and mortality risk: A meta-analytic review. PLoS Medicine, 7(7), e1000316. https://doi.org/10.1371/journal.pmed.1000316 Office of the Surgeon General. (2023). Our epidemic of loneliness and isolation: The U.S. Surgeon General's advisory on the healing effects of social connection and community. U.S. Department of Health and Human Services. https://www.hhs.gov/sites/default/files/surgeon-general-social-connection-advisory.pdf Waldinger, R. J., & Schulz, M. S. (2010). What's love got to do with it? Social functioning, perceived health, and daily happiness in married octogenarians. Psychology and Aging, 25(2), 422–431. https://doi.org/10.1037/a0019087 Neuroscience — Oxytocin, Polyvagal Theory & Community Biology Carter, C. S. (1998). Neuroendocrine perspectives on social attachment and love. Psychoneuroendocrinology, 23(8), 779–818. https://doi.org/10.1016/S0306-4530(98)00055-9 Eisenberger, N. I., & Lieberman, M. D. (2004). Why rejection hurts: A common neural alarm system for physical and social pain. Trends in Cognitive Sciences, 8(7), 294–300. https://doi.org/10.1016/j.tics.2004.05.010 Heinrichs, M., Baumgartner, T., Kirschbaum, C., & Ehlert, U. (2003). Social support and oxytocin interact to suppress cortisol and subjective responses to psychosocial stress. Biological Psychiatry, 54(12), 1389–1398. https://doi.org/10.1016/S0006-3223(03)00465-7 Porges, S. W. (2011). The polyvagal theory: Neurophysiological foundations of emotions, attachment, communication, and self-regulation. W. W. Norton & Company. https://wwnorton.com/books/9780393707007 Blue Zones Research Buettner, D., & Skemp, S. (2016). Blue Zones: Lessons from the world's longest lived. American Journal of Lifestyle Medicine, 10(5), 318–321. https://doi.org/10.1177/1559827616637066 Kreouzi, M., Theodorakis, N., & Constantinou, C. (2022). Lessons learned from Blue Zones, lifestyle medicine pillars and beyond. American Journal of Lifestyle Medicine. https://doi.org/10.1177/15598276221118494 Suzuki, M., Willcox, B. J., & Willcox, D. C. (2001). Implications from and for food cultures for cardiovascular disease: Longevity. Asia Pacific Journal of Clinical Nutrition, 10(2), 165–171. https://doi.org/10.1111/j.1440-6047.2001.00219.x The power of environment: A comprehensive review of the exposome's role in healthy aging. (2025). PubMed Central (PMC11858149). https://pmc.ncbi.nlm.nih.gov/articles/PMC11858149/ Social Capital & Community Decline Oldenburg, R. (1999). The great good place: Cafés, coffee shops, bookstores, bars, hair salons, and other hangouts at the heart of a community. Marlowe & Company. https://books.google.com/books?id=cK80BwAAQBAJ Putnam, R. D. (2000). Bowling alone: The collapse and revival of American community. Simon & Schuster. https://www.simonandschuster.com/books/Bowling-Alone/Robert-D-Putnam/9780743203043 Sbarra, D. A., Briskin, J. L., & Slatcher, R. B. (2019). Smartphones and close relationships: The case for an evolutionary mismatch. Perspectives on Psychological Science, 14(4), 596–618. https://doi.org/10.1177/1745691619826535 Twenge, J. M., Joiner, T. E., Rogers, M. L., & Martin, G. J. (2018). Increases in depressive symptoms, suicide-related outcomes, and suicide rates among U.S. adolescents after 2010 and links to increased new media screen time. Journal of Adolescent Health, 62(1), 78–85. https://doi.org/10.1016/j.jadohealth.2017.06.014 U.S. Bureau of Labor Statistics. (2020). American time use survey. U.S. Department of Labor. https://www.bls.gov/tus/ Pennebaker & Authentic Disclosure Brown, B. (2012). Daring greatly: How the courage to be vulnerable transforms the way we live, love, parent, and lead. Gotham Books. https://brenebrown.com/book/daring-greatly/ Pennebaker, J. W. (1997). Writing about emotional experiences as a therapeutic process. Psychological Science, 8(3), 162–166. https://doi.org/10.1111/j.1467-9280.1997.tb00403.x

In this episode of the Language on the Move Podcast, Tazin Abdullah speaks with Dr. Oludamini Oguannaike, Associate Professor of African Religious Thought and Democracy at the University of Virginia. Tazin and Oludamini talk about his work into how languages, such as English, express concepts that originate from onto-epistemic perspectives that are not historically associated with the English language. They discuss his 2019 article “Islam in English,” which he co-authored with Dr. Mohammed Rustom and how this research is expressed in the literary genre in his book of poetry called The Book of Clouds. The conversation considers how the distinctive philosophical and metaphysical concepts associated with Islam collide with the use of English as a result of the global dominance of English. Tazin and Oludamini discuss how he has used his research and knowledge of historical religious thought to express these concepts using English in poetry. References Ogunnaike, O. (2024). The Book of Clouds. Fons Vitae of Kentucky. Ogunnaike, O., & Rustom, M. (2019). Islam in English. American Journal of Islamic Social Sciences, 36(2), 102-111. For additional resources, show notes, and transcripts, go here. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/new-books-network

Michael Shermer speaks with Oxford philosopher Carissa Véliz about the long human desire to know the future—from ancient oracles and astrology to AI, surveillance capitalism, predictive policing, and "data-driven" decision-making. Véliz argues that prediction is rarely neutral: the same machinery that collects personal data also tries to forecast behavior, and once institutions start treating predictions as facts, forecasts can become tools of control. The conversation gets into why privacy matters for democracy, how algorithms can turn human lives into self-fulfilling prophecies, and why extraordinary people often fall outside predictive models. Shermer and Véliz also discuss the limits of science, the replication crisis, crime statistics, effective altruism, utilitarian ethics, and free will. Carissa Véliz is an associate professor at the Institute for Ethics in AI at the University of Oxford. Her first book, Privacy Is Power (Melville House) was an Economist book of the year and has been published in seven languages. Her academic work has been published in The Harvard Business Review, Nature, AI & Society, and The American Journal of Bioethics, among others. Her new book is Prophecy: Prediction, Power, and the Fight for the Future, from Ancient Oracles to AI.

If you've been feeling exhausted, tired, bloated, anxious, in pain, or just not like yourself, you need to hear today's episode. Today, Mel sits down with one of the most respected medical researchers in the world, gastroenterologist Dr. Brennan Spiegel, to uncover the overlooked, invisible force that's having a shocking impact on your energy, strength, gut health, mood, and every single cell in your body – even how fast your body ages.   Whether you're dealing with fatigue, back pain, swelling, digestion issues, or a heaviness in your body that you can't shake, Dr. Spiegel says these are all signs you shouldn't ignore.   Dr. Spiegel is a gastroenterologist and the director of Health Services Research at Cedars-Sinai Medical Center in Los Angeles, one of the leading medical centers in the United States. He is also a professor of medicine and public health at UCLA.  He trained at Cedars-Sinai and UCLA, and is a pioneering researcher in the areas of gut health, the usage of AI in medicine, and tools that help patients with pain, anxiety, and chronic illness.  He's the founding editor of the Journal of Medical Extended Reality and he served as Editor-in-Chief of the American Journal of Gastroenterology.  Dr. Spiegel has published more than 300 peer-reviewed scientific papers, his research has been cited 30,000 times, and he is the author of Pull: How Gravity Shapes Your Body, Steadies the Mind, and Guides Our Health. What Dr. Spiegel reveals will challenge the way you think about your body and, more importantly, give you a completely new, practical way to start feeling better immediately. And it may give you the words and the insight you've been missing to help your aging parents and other loved ones finally start feeling better, too.   By the end of this episode, you'll understand: -Why a “bendy” pinky might be a clue to what's going on in your gut -10 foods that boost serotonin production in your body -The most effective treatment for IBS - and it's probably not what you've tried -A quick way to notice how the force of gravity is showing up in your body -How to make yourself taller in just a few minutes -Why standing on one leg is linked to a longer life -How a weighted vest can change your posture almost immediately -A surprising reason rollercoasters feel unbearable for some people -What “gravity management” looks like in real life  -One small habit that can improve how your body handles gravity Dr. Spiegel says the powerful, invisible force shaping every moment of your life is one you can learn to work with – and he'll show you how.   This is one of those conversations that will change how you see your body, your health, and what it means to be fully alive. For more resources related to today's episode, click here for the podcast episode page:     If you liked the episode, check out this one next: Change Your Body & Your Life in 1 Month: 4 Small Habits That Actually Work.   Connect with Mel:     Order Mel's new product, Pure Genius Protein Get Mel's newsletter, packed with tools, coaching, and inspiration. Get Mel's #1 bestselling book, The Let Them Theory Watch the episodes on YouTube Follow Mel on Instagram  The Mel Robbins Podcast Instagram Mel's TikTok  Subscribe to SiriusXM Podcasts+ to listen to new episodes ad-free Disclaimer Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Content warning: childhood abuse, childhood sexual abuse, sexual assault, rape, abduction, missing persons, gun violence, murder, and mental illness.Amber Rodgers is a survivor, business professional, and creative from Texas. As early as she can remember, her life was filled with chaos. By the time she was fourteen, she was a multi-crime survivor, and by 19 she would serve as a witness in her best friend's murder trial. Amber moved forward by cultivating a successful career and loving family, until her past trauma instigated a cascading effect in her mental health and relationships. Although Amber has shared portions of her story at-large, it took her decades and a life-altering mental health journey to realize the deep impact her teen years had had on her. The Broken Cycle Media team is deeply appreciative of Amber's transparency, rawness, and advocacy. These episodes are dedicated in loving memory of Kytrina Marie Locascio.Sources: -Centers for Disease Control and Prevention. “About Adverse Childhood Experiences.” CDC, U.S. Department of Health and Human Services, 2025, https://www.cdc.gov/violenceprevention/aces/. -Centers for Disease Control and Prevention. “Adverse Childhood Experiences (ACEs).” CDC Vital Signs, U.S. Department of Health and Human Services, https://www.cdc.gov/vitalsigns/aces/index.html. -Centers for Disease Control and Prevention. “Psychosocial Factors and Health Equity.” CDC, U.S. Department of Health and Human Services, https://www.cdc.gov/dhdsp/health_equity/psychosocial.htm. -Felitti, Vincent J., et al. “Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults: The Adverse Childhood Experiences (ACE) Study.” American Journal of Preventive Medicine, vol. 14, no. 4, 1998, pp. 245–258.-Hughes, Karen, et al. “The Effect of Multiple Adverse Childhood Experiences on Health: A Systematic Review and Meta-Analysis.” The Lancet Public Health, vol. 2, no. 8, 2017, pp. e356–e366. doi:10.1016/S2468-2667(17)30118-4.-McKay, Matthew T., Laura Kilmartin, Aisling Meagher, Mary Cannon, Colm Healy, and Mary C. Clarke. “A Revised and Extended Systematic Review and Meta-Analysis of the Relationship between Childhood Adversity and Adult Psychiatric Disorder.” Journal of Psychiatric Research, vol. 156, 2022, pp. 159–174. PubMed, https://pubmed.ncbi.nlm.nih.gov/36274532/. -Swedo, Elizabeth A., et al. “Prevalence of Adverse Childhood Experiences Among U.S. Adults—Behavioral Risk Factor Surveillance System, 2011–2020.” Morbidity and Mortality Weekly Report, vol. 72, no. 26, 2023, pp. 707–715, https://www.cdc.gov/mmwr/volumes/72/wr/mm7226a2.htm. -Zhang, Y., et al. “Cumulative Adverse Childhood Experiences and Risk of Mental Disorders: A Systematic Review and Meta-Analysis.” Acta Psychiatrica Scandinavica, 2026, https://www.sciencedirect.com/science/article/pii/S0001691826007559. Accessed 2 June 2026.For additional resources and a list of non-profit organizations that can help, please visit http://www.somethingwaswrong.com/resources*Thank you again to Rula and Quince for sponsoring this episode. *Remember, Rula patients typically pay $15 per session when using insurance. Connect with quality therapists and mental health experts who specialize in you at https://www.rula.com/wcn #rulapod *And don't forget to elevate your summer wardrobe, go to quince.com/wcn for free shipping on your order and 365-day returns, now available in Canada too.

Welcome to this week's Midlife Minute. Today, I'm focusing on all the questions I received about gallbladder health, including HRT-provoking symptoms, supplements that improve gallbladder health, and evidence-based food interventions. IN THIS EPISODE, YOU WILL LEARN: Why the risk of gallstones and gallbladder inflammation increases during the menopause transition How estrogen and progesterone HRT have different effects on gallbladder functioning The differences in risk between transdermal and oral HRT How the progesterone in HRT can cause gallbladder issues in some women What TUDCA is, and how it supports gallbladder health The value of TUDCA for women who have had their gallbladders removed How various nutrients and supplements support bile flow and gallbladder health What can contribute to gallstone formation Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website. Submit your questions to support@cynthiathurlow.com  Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow.  Purchase Cynthia's book, The Menopause Gut. Cynthia's Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Gallbladder Research: Cabrera D, Arab JP, Arrese M. UDCA, NorUDCA, and TUDCA in liver diseases: a review of their mechanisms of action and clinical applications. Seminars in Liver Disease. 2019;39(4):397–404. doi:10.1055/s-0039-1696799  Vang S, Longley K, Steer CJ, Low WC. The unexpected uses of urso- and tauroursodeoxycholic acid in the treatment of non-liver diseases. Global Advances in Health and Medicine. 2014;3(3):58–69. doi:10.7453/gahmj.2014.017  Bai M, Yang L, Liao H, et al. Tauroursodeoxycholic acid improves nonalcoholic fatty liver disease by regulating gut microbiota and bile acid metabolism. Journal of Agricultural and Food Chemistry. 2024;72(41):22655–22668. doi:10.1021/acs.jafc.4c04630  Simon JA, Hudes ES. Relation of serum ascorbic acid to serum vitamin B12, serum ferritin, and kidney stones in US adults. *Archives of Internal Medicine.*1999;159(6):619–624. doi:10.1001/archinte.159.6.619  Walcher T, Haenle MM, Kron M, et al. Vitamin C supplement use may protect against gallstones: an observational study on a randomly selected population. BMC Gastroenterology. 2009;9:74. doi:10.1186/1471-230X-9-74  Tsai CJ, Leitzmann MF, Willett WC, Giovannucci EL. Long-term intake of dietary fiber and decreased risk of cholecystectomy in women. American Journal of Gastroenterology. 2004;99(7):1364–1370. doi:10.1111/j.1572-0241.2004.30281.x  Leitzmann MF, Stampfer MJ, Willett WC, Spiegelman D, Colditz GA, Giovannucci EL. Coffee intake is associated with lower risk of symptomatic gallstone disease in women. Gastroenterology. 2002;123(6):1823–1830. doi:10.1053/gast.2002.37085  Moerman CJ, Smeets FW, Kromhout D. Dietary risk factors for clinically diagnosed gallstones in middle-aged men — a 25-year follow-up study. Annals of Epidemiology. 1994;4(3):248–254. doi:10.1016/1047-2797(94)90099-x Association between dietary magnesium intake and gallstones: the mediating role of atherogenic index of plasma. Lipids in Health and Disease. 2024;23(1):82. doi:10.1186/s12944-024-02074-4  Pitt HA, Doty JE, Murphy MM, Schwarz MB. Progesterone alters biliary flow dynamics. Annals of Surgery. 1999;229(2):205–209. doi:10.1097/00000658-199902000-00008

Dust off your aprons and heat up your cast iron because it's finally time for one of our most requested episodes yet! In this episode, Hannah and Marcelle dig deep into the tradwife phenomenon. Using the viral tradwife influencer Ballerina Farm as a case study, Hannah leads us through a discussion about eugenics, replacement theory, and clean living movements. They also get into influencer culture, the performance of farm life, and…milk. Whew! That's a lot, and it's ALL relevant.This episode is for those of you who love to hate tradwives, are curious about their meteoric rise in popularity over the last few years, or have never even heard of them!Related listening:9 to 5 x Labour Feminism with Zena SharmanGet Out x Horrifying WhitenessWitch, Please: Book 7, Ep. 6 | EugenicsWorks Cited:Agnew, Megan. “Meet the queen of the ‘trad wives' (and her eight children.” The Times 20 July 2024: https://archive.ph/YHB08. “Clean living movement.” Wikipedia. https://en.wikipedia.org/wiki/Clean_living_movement. Accessed 14 May 2026. Elster, N., Parsi, K., & Caplan, A. Guest editorial. “Laundering Public Health: Using Autism to Revive Eugenics.” The American Journal of Bioethics (2026): 1–3. https://doi.org/10.1080/15265161.2026.2659519. “Eugenics and Scientific Racism.” National Human Genome Research Institute 18 May 2022. https://www.genome.gov/about-genomics/fact-sheets/Eugenics-and-Scientific-Racism. Accessed 14 May 2026. Luse, Brittany. “Mormon Moms: Unpacking a national obsession.” It's Been A Minute (NPR) 12 November 2024: https://www.npr.org/transcripts/1212541651. Moskin, Julia. “Tycoon or Tradwife? The Woman Behind Ballerina Farm Makes Her Own Path.” The New York Times 3 December 2024: https://archive.ph/Q9j2J#selection-489.0-489.70. Petersen, Anne Helen. “The Edenic Allure of Ballerina Farm.” Culture Study 10 February 2022: https://annehelen.substack.com/p/the-edenic-allure-of-ballerinafarm. Sykes, Sophia and Dr Veronica Hopner. “Tradwives: The Housewives Commodifying Right-Wing Ideology.” Global Network on Extremism & Technology 7 July 2023: https://gnet-research.org/2023/07/07/tradwives-the-housewives-commodifying-right-wing-ideology/. Valverde, Mariana. The Age of Light, Soap, and Water: Moral Reform in English Canada, 1885-1925. Toronto: McClelland & Stewart, 1991.***To learn more about Material Girls, head to our Instagram at instagram.com/ohwitchplease! Or check out our website ohwitchplease.ca. We'll be back next week with a Material Concerns episode, but until then, go check out all the other content we have on our Patreon at Patreon.com/ohwitchplease! Patreon is how we produce the show and pay our team!Material Girls is a show that makes sense of the zeitgeist through materialist critique* and critical theory! Each episode looks at a unique object of study (something popular now or from back in the day) and over the course of three distinct segments, Hannah and Marcelle apply their academic expertise to the topic at hand.*Materialist Critique is, at its simplest possible level, a form of cultural critique – that is, scholarly engagement with a cultural text of some kind – that is interested in modes of production, moments of reception, and the historical and ideological contexts for both.Music Credits:“Shopping Mall”: by Jay Arner and Jessica Delisle ©2020Used by permission. All rights reserved. As recorded by Auto Syndicate on the album “Bongo Dance”.Hosted on Acast. See acast.com/privacy for more information. Hosted on Acast. See acast.com/privacy for more information.

Welcome back, everyone. Today we're diving into one of the most hotly debated topics in obstetrics- should we be treating preeclampsia without severe features with antihypertensive medications during expectant management? Now, if you've been following the literature- and our show, you know that the landmark CHAP trial changed the game for chronic hypertension in pregnancy. It showed us that targeting a blood pressure below 140 over 90 reduces serious maternal complications, without harming the baby. That was a big deal. But here's the thing, CHAP studied chronic hypertension. Then there was the CHIP trial- that also found that tight control of gestational hypertension and nonproteinuric chronic hypertension was also beneficial. These did not address preeclampsia without severe features, and yet, the ripple effects of that trial have sparked a global conversation about whether we should be extending those same treatment principles to women with preeclampsia who don't yet have severe features. And this is where it gets really interesting, because the guidelines don't agree. In the United States, ACOG and the Society for Maternal-Fetal Medicine still say: hold off on antihypertensives unless blood pressures hit the severe range at 160/110. But step outside the US, and you'll find the World Health Organization, the International Society for the Study of Hypertension in Pregnancy, FIGO, NICE, and Hypertension Canada all recommending treatment at 140 over 90, regardless of whether the diagnosis is chronic hypertension, gestational hypertension, or preeclampsia. So who's right? And more importantly what does this mean for the patient sitting in front of you right now, at 34 weeks, with a blood pressure of 150 over 95, some proteinuria, but no severe features? Today, we're going to break this down. We'll review the controversy, walk through the divergent guidelines, and most importantly talk about the real, practical implications that favor treating these patients during expectant management. Because when you're watching someone with preeclampsia, waiting for the right time to deliver, there's a strong argument that controlling their blood pressure isn't just reasonable…may be protective. So grab your coffee, settle in, and let's get into it.1. Society for Maternal-Fetal Medicine Statement: Antihypertensive Therapy For mild chronic Hypertension in Pregnancy-The Chronic Hypertension And Pregnancy Trial. American Journal of Obstetrics and Gynecology. 2022. Society for Maternal-Fetal Medicine; Publications Committee. 2. Preeclampsia. The New England Journal of Medicine. 2022. Magee LA, Nicolaides KH, von Dadelszen P.3. Antihypertensive Drug Therapy for Mild to Moderate Hypertension During Pregnancy.The Cochrane Database of Systematic Reviews. 2018. Abalos E, Duley L, Steyn DW, C.4. Prevention and Treatment of Maternal Stroke in Pregnancy and Postpartum: A Scientific Statement From the American Heart Association. Stroke. 2026. Miller EC, Bello NA, Chen PR, et al.5.Hypertension in Pregnancy: Diagnosis, Blood Pressure Goals, and Pharmacotherapy: A Scientific Statement From the American Heart Association. Hypertension. 2022. Garovic VD, Dechend R, Easterling T, et al.

Carlos Juan Finlay was a Cuban doctor who did a lot of work to understand the spread of Yellow Fever. But Walter Reed got most of the credit. Research: American Experience. “Carlos Finlay (1833-1915).” From The Great Fever. PBS. https://www.pbs.org/wgbh/americanexperience/features/fever-carlos-finlay/ Berenbrok, Dorothy E., "Latin Heritage Month. Carlos Juan Finlay: Outrageous, Courageous and Correct" (2015). Posters: Jefferson History. 3. https://jdc.jefferson.edu/jeffhistoryposters/3 "Carlos Juan Finlay." Encyclopedia of World Biography Online, Gale, 1998. Gale In Context: Opposing Viewpoints, link.gale.com/apps/doc/K1631002194/GPS?u=mlin_n_melpub&sid=bookmark-GPS&xid=bfeecc25. Accessed 29 Apr. 2026. Chaves-Carballo, Enrique. “Carlos J. Finlay: The mosquito man.” Hektoen International. 11/2/2020. https://hekint.org/2020/11/02/carlos-j-finlay-the-mosquito-man/ Corbitt, Duvon C. “Carlos J. Finlay, Cuban Physician.” The Hispanic American Historical Review, Vol. 45, No. 3 (Aug., 1965). Via JSTOR. https://www.jstor.org/stable/2511751 Del Regato, Juan A. “Carlos Juan Finlay (1833-1915).” Journal of Public Health Policy , 2001, Vol. 22, No. 1 (2001). Via JSTOR. https://www.jstor.org/stable/3343556 Faerstein, Eduardoa; Winkelstein, Warren Jrb. Carlos Juan Finlay: Rejected, Respected, and Right. Epidemiology 21(1):p 158, January 2010. | DOI: 10.1097/EDE.0b013e3181c308e0 Ferreira Moreno, Víctor Guillermo. “Evocation to the Dr. Carlos J. Finlay Barres on the centennial of his death.” Colombia medica (Cali, Colombia) vol. 47,1 63-6. 30 Mar. 2016 Finlay, Carlos J. “The Mosquito Hypothetically Considered as the Agent of Transmission of Yellow Fever.” Read before the Royal Academy of Medical, Physical and Natural Sciences Session of August 14th, 1881. https://archive.org/details/b33448541/page/590/mode/1up Finlay, Carlos Juan. “Trabajos selectos del Dr. Carlos J. Finlay. Selected papers of Dr. Carlos J. Finlay.” Habana. 1912. https://archive.org/details/trabajosselectos00finl Finlay, Charles. “Inoculations for Yellow Fever by Means of Contaminated Mosquitoes.” Published in The American Journal of the Medical Sciences, n.s. 102: 264-268, 1891. https://archive.org/details/b33445242/page/n4/mode/1up Finlay, Charles. “Yellow Fever: Its ‘Transmission by Means of the Culex Mosquito.” Published in The American Journal of the Medical Sciences, n.s. 92: 395-409, 1886. https://archive.org/details/b33435698/page/613/mode/1up Palmer, Steven. “A Cuban Scientist Between Empires: Peripheral Vision on Race and Tropical Medicine.” Canadian Journal of Latin American and Caribbean Studies / Revue canadienne desétudes latino-américaines et caraïbes, Vol. 35, No. 69, Special Issue: Landscapes of LatinAmerican Health, 1870-1970. Via JSTOR. https://www.jstor.org/stable/41800498 Spears, Ellen Griffith and Rosa López-Oceguera. “Carlos Juan Finlay, William Gorgas, and Walter Reed and the U.S. Army Yellow Fever Controversy: Competing Historical Memories.” Alabama Review The University of Alabama Press. Volume 74, Number 1, January 2021. https://doi.org/10.1353/ala.2021.0011 Stepan, Nancy. “The Interplay between Socio-Economic Factors and Medical Science: Yellow Fever Research, Cuba and the United States.” Social Studies of Science , Nov., 1978, Vol. 8, No. 4 (Nov., 1978). Via JSTOR. http://www.jstor.com/stable/284817 Thomas Jefferson University. “10 Notable Jefferson Alumni of the Past.” https://library.jefferson.edu/archives/exhibits/notable_alumni/juan_carlos_finlay.cfm Tone, John Lawrence. (2002) “How the mosquito (man) liberated Cuba.” History and Technology, 18:4, 277-308, DOI: 10.1080/07341512.2002.11417735 “Carlos J. Finlay.” 5/16/2023. https://www.unesco.org/en/prizes/carlos-j-finlay/about Woodall, Jack. "Yellow Fever." Infectious Diseases: In Context, edited by Brenda Wilmoth Lerner and K. Lee Lerner, vol. 2, Gale, 2008, pp. 925-931. In Context Series. Gale In Context: Opposing Viewpoints, link.gale.com/apps/doc/CX3045200265/GPS?u=mlin_n_melpub&sid=bookmark-GPS&xid=bf646a26. Accessed 29 Apr. 2026. See omnystudio.com/listener for privacy information.

The Carrington Event was a massive geomagnetic storm that happened in 1859. It led to expanded understanding of solar phenomena. Research: “Great Aurora of 1859. Art. XLII – The Great Auroral Exhibition of August 28th to September 4th, 1859.” American Journal of Science. Ser. 2. Vol. 28. July-November 1859. Cardenas, Freddy Moreno et al. “The Grand Aurorae Borealis Seen in Colombia in 1859.” Preprint submitted to Advances in Space Research. August 21, 2015. Cliver, E.W. “The 1859 space weather event: Then and now.” Advances in Space Research. 38 (2006) 119-129. Cliver, E.W. and L. Svalgaard. “The 1859 Solar-Terrestrial Disturbance and the Current Limits of Extreme Space Weather Activity.” Solar Physics. (2004) 224: 407–422. Cliver, Edward W. and William F. Dietrich. “The 1859 space weather event revisited: limits of extreme activity.” J. Space Weather Space Clim. 3 (2013) A31 DOI:10.1051/swsc/2013053 Dobrijevic, Daisy and Andrew May. “The Carrington Event: History's greatest solar storm.” Space.com. 5/20/2022. https://www.space.com/the-carrington-event Giegengack, Robert. “The Carrington Coronal Mass Ejection of 1859.” Proceedings of the American Philosophical Society , DECEMBER 2015, Vol. 159, No. 4. Via JSTOR.https://www.jstor.org/stable/26159195 Green, James L, and Scott Boardsen. “Duration and extent of the great auroral storm of 1859.” Advances in space research : the official journal of the Committee on Space Research (COSPAR) vol. 38,2 (2006): 130-135. doi:10.1016/j.asr.2005.08.054 Green, James L. et al. “Eyewitness Reports of the Great Auroral Storm of 1859.” Submitted to Advances in Space Research. NASA Technical Reports Server (NTRS) 20050210157. 8/5/2005. Haeberle, Tom. “The Carrington Affair!” Amateur Astronomers Association Eyepiece. 9/1/2018. https://aaa.org/2018/09/01/the-carrington-affair/ Hayakawa, Hisashi et al. “Temporal and Spatial Evolutions of a Large Sunspot Group and Great Auroral Storms Around the Carrington Event in 1859.” Space Weather. 8/29/2019. https://agupubs.onlinelibrary.wiley.com/doi/full/10.1029/2019SW002269 Hodgson, R. “On a Curious Appearance Seen in the Sun.” Monthly notices of the Royal Astronomical Society vol. 19-20 (1858-1860). https://academic.oup.com/mnras/article/20/1/15/983497 Hodžić, Jasna. “The Carrington Event of 1859 Disrupted Telegraph Lines. A ‘Miyake Event’ Would Be Far Worse.” JSTOR Daily. 9/7/2023. https://daily.jstor.org/the-carrington-event-of-1859-disrupted-telegraph-lines/ Howard, R.A. (2006). A Historical Perspective on Coronal Mass Ejections. In Solar Eruptions and Energetic Particles (eds N. Gopalswamy, R. Mewaldt and J. Torsti). https://doi.org/10.1029/165GM03 Josefowicz, Diane. “The British Magnetic Scheme (1839-1851): People and Institutions.” Victorian Web. https://victorianweb.org/science/geomagnetism/magneticcrusade.html Kaminski, Isabella. “'The fate of nations and the fall of kingdoms': History's epic theories of what causes aurora.” BBC. 11/16/2025. https://www.bbc.com/future/article/20251114-historys-epic-theories-of-what-causes-aurora Kimball, D.S. “A Study of the Aurora of 1859.” Scientific Report No. 6. NSF Grant No. Y/22.6/327. April 1960. Klein, Christopher. “A Perfect Solar Superstorm: The 1859 Carrington Event.” History. 1/29/2025. https://www.history.com/articles/a-perfect-solar-superstorm-the-1859-carrington-event Marinus Anthony van der Sluijs, Hisashi Hayakawa. “A candidate auroral report in the Bamboo Annals, indicating a possible extreme space weather event in the early 10th century BCE.” Advances in Space Research. Volume 72, Issue 12. 2023. https://doi.org/10.1016/j.asr.2022.01.01 Mills, Virginia. “A message from Alexander von Humboldt.” The Royal Society. 9/23/2019. https://royalsociety.org/blog/2019/09/a-message-from-alexander-von-humboldt/ Muller, C. “The Carrington solar flares of 1859: consequences on life.” Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life vol. 44,3 (2014): 185-95. doi:10.1007/s11084-014-9368-3 Phillips, Tony. “A Warning from History: The Carrington Event Was Not Unique.” Space Weather Archive. 9/1/2020. https://spaceweatherarchive.com/2020/08/30/a-warning-from-history-the-carrington-event-was-not-unique/ Phillips, Tony. “Near Miss: The Solar Superstorm of July 2012.” NASA. 12/22/2014. https://science.nasa.gov/science-research/planetary-science/23jul_superstorm/ C. Carrington, Description of a Singular Appearance seen in the Sun on September 1, 1859, Monthly Notices of the Royal Astronomical Society, Volume 20, Issue 1, November 1859, Pages 13–15, https://doi.org/10.1093/mnras/20.1.13 Starmans, Barbara J. “Carrington Solar Flare of 1859.” The Social Historian. 11/27/2016. https://www.thesocialhistorian.com/carrington-solar-flare-of-1859/ Thompson, D. (2009) The Carrington Event and the Electric Telegraph in Victoria in Museums Victoria Collections https://collections.museumsvictoria.com.au/articles/2880 See omnystudio.com/listener for privacy information.