Podcasts about cold spring harbor

happy new year wrap acast billy joel cold spring harbor

Play Episode Listen Later Jan 9, 2024 43:42

Happy New Year everyone. Welcome to the home stretch of the Billy Joel A to Z podcast as we open the brand new year with the oldest and the first of Billy Joel's album, Cold Spring Harbor. The Cold Spring Harbor Album was released November 1, 1971 and holds 2 songs that have been Billy Joel staples over the years. She's Got A Way is how we all may have discovered Billy Joel but Everybody Loves You Now has, now that he has relaxed on the horrors of this album's release, become a concert staple. This is an incredibly interesting album in how it shaped Billy Joel's career and holds some hidden gems that he should think about revisiting. But don't worry, we revisit them here thanks to the great Paul Loren who joins us as usual, with songs, rankings, parodies and talking our favorite singer songwriter, Sir William Joel. Hosted on Acast. See acast.com/privacy for more information.

Cold Spring Harbor Album Wrap Up - Part 1

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Play Episode Listen Later Jan 2, 2024 40:51

Happy New Year everyone. Welcome to the home stretch of the Billy Joel A to Z podcast as we open the brand new year with the oldest and the first of Billy Joel's album, Cold Spring Harbor. The Cold Spring Harbor Album was released November 1, 1971 and holds 2 songs that have been Billy Joel staples over the years. She's Got A Way is how we all may have discovered Billy Joel but Everybody Loves You Now has, now that he has relaxed on the horrors of this album's release, become a concert staple. This is an incredibly interesting album in how it shaped Billy Joel's career and holds some hidden gems that he should think about revisiting. But don't worry, we revisit them here thanks to the great Paul Loren who joins us as usual, with songs, rankings, parodies and talking our favorite singer songwriter, Sir William Joel. Hosted on Acast. See acast.com/privacy for more information.

SPOTLIGHT ON SCHOOLS 1-27-24 Cold Spring Harbor

Empowered Patient Podcast

Play Episode Listen Later Dec 19, 2023 20:55

SPOTLIGHT ON SCHOOLS 1-27-24 Cold Spring Harbor by JVC Broadcasting

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Developing Phosphatase Inhibitors to Treat Rare Neurodevelopmental Disorder with Andreas Grill DepYmed

Play Episode Listen Later Nov 20, 2023 19:57

Andreas Grill, President and CEO of DepYmed, discusses protein tyrosine phosphatase-targeted drugs, a new class of drugs. With a focus on the specific enzyme PTP1B, DepYmed discovered orally bioavailable molecules that inhibit PTP1B, targeting the signal transaction pathway. They are initially testing to treat Rett syndrome, a rare disease with no current therapy while exploring the use of PTP1B inhibitors to treat inflammatory diseases, cancer, diabetes, and neurological diseases. Andreas elaborates, "In DepYmed, we're focused on a specific enzyme. It's PTP1B. It's part of a family of enzymes called protein tyrosine phosphatases, and, in particular, we're looking at PTP1B. It's a metabolic regulatory enzyme that regulates signal transduction between cells and how cells communicate with each other. It's been worked on in the '90s and early 2000s. A couple of companies were working on the target, and they failed in the target, mainly because they couldn't create an orally bioavailable compound that would inhibit the PTP1B enzyme itself." "So that was one of the holy grails that we were able to find, where we were able to discover molecules that were orally bioavailable and would inhibit PTP1B. It was a game-changer when it came to the therapeutics around the target of PTP1B. Much of this work came out of Dr. Nicholas Tonks' laboratory out of Cold Spring Harbor Laboratory. We are in close collaboration with Nick and his team at Cold Spring Harbor, developing this new area of PTP1B inhibitors targeting the signal transaction pathway." #DepYmed #RettSyndrome #DPM1003 #PTP1B #Phosphatases #PhosphatasesInhibitors #RareDisease DepYmed.com Download the transcript here

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Developing Phosphatase Inhibitors to Treat Rare Neurodevelopmental Disorder with Andreas Grill DepYmed TRANSCRIPT

Empowered Patient Podcast

Play Episode Listen Later Nov 20, 2023

Andreas Grill, President and CEO of DepYmed, discusses protein tyrosine phosphatase-targeted drugs, a new class of drugs. With a focus on the specific enzyme PTP1B, DepYmed discovered orally bioavailable molecules that inhibit PTP1B, targeting the signal transaction pathway. They are initially testing to treat Rett syndrome, a rare disease with no current therapy while exploring the use of PTP1B inhibitors to treat inflammatory diseases, cancer, diabetes, and neurological diseases. Andreas elaborates, "In DepYmed, we're focused on a specific enzyme. It's PTP1B. It's part of a family of enzymes called protein tyrosine phosphatases, and, in particular, we're looking at PTP1B. It's a metabolic regulatory enzyme that regulates signal transduction between cells and how cells communicate with each other. It's been worked on in the '90s and early 2000s. A couple of companies were working on the target, and they failed in the target, mainly because they couldn't create an orally bioavailable compound that would inhibit the PTP1B enzyme itself." "So that was one of the holy grails that we were able to find, where we were able to discover molecules that were orally bioavailable and would inhibit PTP1B. It was a game-changer when it came to the therapeutics around the target of PTP1B. Much of this work came out of Dr. Nicholas Tonks' laboratory out of Cold Spring Harbor Laboratory. We are in close collaboration with Nick and his team at Cold Spring Harbor, developing this new area of PTP1B inhibitors targeting the signal transaction pathway." #DepYmed #RettSyndrome #DPM1003 #PTP1B #Phosphatases #PhosphatasesInhibitors #RareDisease DepYmed.com Listen to the podcast here

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Why Judy Why

acast billy joel oy cold spring harbor

Play Episode Listen Later Oct 24, 2023 32:10

Why Judy Why is the first song we've covered in an entire year from Billy Joel's first album ever entitled, Cold Spring Harbor. Totally worth the wait. This beautiful song (now at the correct speed) is apparently about Billy Joel's sister. And why not? We've already heard about his wives, mother and childhood sweetheart - Judy was due. Again, another song where at the ripe old age of 20, he feels like he's missed out. Oy. Hosted on Acast. See acast.com/privacy for more information.

EP 096 - Concert Classics: Live At Sigma Sound Studios, Philadelphia - 1972

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Play Episode Listen Later Oct 10, 2023 80:17

Unreleased for decades, Billy Joel's 1972 Sigma Sound Studios concert was arguably the kick-start to his career. With a flop record in Cold Spring Harbor under his belt. Billy and his then-backing band performed live on the air for WMMR in Philadelphia. The session yielded a version of “Captain Jack” that became the station's most-requested song for years. It drew the attention of Columbia Records, who went on to sign Billy and release Piano Man in late 1973. And, as famed as that track is, there's plenty more to enjoy from this performance, which was included on the November 2011 deluxe Legacy Edition reissue of Piano Man. It's a rare official recording documenting the pre-Lords of 52nd Street live unit. And, it features tracks that never made it on a record, early versions of now-classics, and songs that Billy permanently dropped from the setlist soon after. Join us as we dig deep into Billy Joel at Sigma Sound Studios in April 1972. Invitation and note courtesy of Paul Fierro Studio photo courtesy of Sigma Sound Studios website ------ Email us: glasshousespodcast@gmail.com Glass Houses - A Billy Joel Podcast on the web / social media: Website: http://www.glasshousespod.com Facebook: https://www.facebook.com/glasshousespodcast/ Instagram: https://www.instagram.com/glasshousespod/ Twitter: https://twitter.com/glasshousespod Discord: https://discord.gg/6G6cMRFu7T Support the podcast: Paypal: https://paypal.me/glasshousespod Venmo: @MGrosvenor Produced by Michael Grosvenor & Jack Firneno for Groove Music Marketing

The true confessions of a bacterial geneticist

Classic Lasker

Play Episode Listen Later Oct 9, 2023 26:48

“The idea of spending your time digging into mysteries…I thought that would be a wonderful way to spend your life.” Evelyn Witkin did spend her life digging into mysteries, and she was recognized with the 2015 Lasker Award for her work that solved one—how some bacteria survived 100x the radiation that killed other cells. Witkin discovered the DNA-damage response, a genetically regulated emergency system that protects the genomes of all living organisms. In an interview with Emmy-nominated writer/director/podcaster Flora Lichtman, Witkin talks about what it was like to be at Cold Spring Harbor in the 1950s, when many major discoveries in molecular biology were made, and tells us a little bit about her hobby in retirement: Victorian poetry.

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The Chris Voss Show Podcast – Risa Gold MD, President of Miracle of Help Charity

The Chris Voss Show

Play Episode Listen Later Oct 6, 2023 32:44

Risa Gold MD, President of Miracle of Help Charity miracleofhelp.org Risa Gold MD, DLFAPA is a board-certified Child & Adolescent Psychiatrist in Cold Spring Harbor, NY. She graduated Cum Laude from Harvard, and earned her medical degree from Columbia University College of Physicians and Surgeons. Dr. Gold completed a residency in Psychiatry at Payne Whitney Clinic, New York Hospital, Cornell and a Fellowship in Child Adolescence Psychiatry at North Shore University Hospital. After serving as the President of the Greater Long Island Psychiatric Society, Dr. Gold was awarded Distinguished Life Fellow of the American Psychiatric Association. Dr. Gold has been in private practice since 1987. After her son returned from a medical service outreach trip in Sierra Leone, he alerted her to the pressing need for health care services in these remote and vulnerable villages. Dr. Gold started MOH USA, Inc to raise funds for a community-led project that would comprise a hospital complex and several small businesses to support it. She is married to Dr. Kenneth Gold & has raised four children.

Where's the Revolution?

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Play Episode Listen Later Oct 3, 2023 24:48

Today on Billy Joel A to Z we come down to our final Unreleased Tracks. This one is entitled "Where's the Revolution". We estimate it to be circa 1971, perhaps part of the Cold Spring Harbor sessions. In this song Billy asks the question, what is the part of the musician during war time - of course he kind of answers that question 10 years later with Goodnight Saigon, so that makes this song, kind of cool. Plus, for some reason, his obsession with the Spanish Civil War continues. Find out why today on Billy Joel A to Z. Hosted on Acast. See acast.com/privacy for more information.

IBS Biomarkers and Diagnostic Diapers With Maria Eugenia Inda-Webb

Meet the Microbiologist

Play Episode Listen Later Sep 22, 2023 31:49

Dr. Maria Eugenia Inda-Webb, Pew Postdoctoral Fellow working in the Synthetic Biology Center at MIT builds biosensors to diagnose and treat inflammatory disorders in the gut, like inflammatory bowel disease and celiac disease. She discusses how “wearables,” like diagnostic diapers and nursing pads could help monitor microbiome development to treat the diseases of tomorrow. Subscribe (free) on Apple Podcasts, Spotify, Google Podcasts, Android, RSS or by email. Ashley's Biggest Takeaways Biosensors devices that engineer living organisms or biomolocules to detect and report the presence of certain biomarkers. The device consists of a bioreceptor (bacteria) and a reporter (fluorescent protein or light). Inda-Webb's lab recently published a paper in Nature about using biosensors (Sub-1.4 cm3 capsule) to detect inflammatory biomarkers in the gut. The work is focused on diagnosing and treating inflammatory bowel disease, but Inda-Webb acknowledged that that is a large research umbrella. The next step for this research is to monitor the use of the biosensor in humans to determine what chemical concentrations are biologically relevant and to show that it is safe for humans to ingest the device. It is believed that the gut microbiome in humans develops in the first 1000 days to 3 years of life. Early dysbiosis in the gut has been linked to disease in adulthood. However, we do not have a good way to monitor (and/or influence) microbiome development. Inda-Webb hopes to use biosensors in diapers (wearables) to monitor microbiome development and prevent common diseases in adulthood. In 2015, Inda-Webb became ASM's first Agar Art Contest winner for her piece, “Harvest System.” Inda-Webb is the 2023 winner of the ASM Award for Early Career Environmental Research, which recognizes an early career investigator with distinguished research achievements that have improved our understanding of microbes in the environment, including aquatic, terrestrial and atmospheric settings. Learn More About ASM's Awards Program Featured Quotes: We engineer bacteria to sense particular molecules of interest—what we call biomarkers—if they are associated with a disease. And then, we engineer a way that the bacteria will produce some kind of molecule that we can measure—what we call reporter—so that could be a fluorescent protein or light, like the one that we have in this device. The issue is that inflammation in the gut is really very difficult to track. There are no real current technologies to do that. That is like a black box. And so, most of what we measure is what comes out from the gut, and has its limitations. It doesn't really represent the chemical environment that you have inside, especially in areas where you're inflamed. So, we really needed technologies to be able to open a window in these areas. The final device that I am actually bringing here is a little pill that the patient would swallow and get into the gut. And then they engineer bacteria that the biosensors, will detect, let's say, nitrous oxide, which is a very transient molecule. And the bacteria are engineered to respond to that in some way—to communicate with the electronics that will wirelessly transmit to your cell phone. And from there, to the gastroenterologist. We make the bacteria produce light. If they sense nitrous oxide, they produce light, the electronics read that, and the [information] finally gets into your phone. Part of the challenge was that we needed to make the electronics very very tiny to be able to fit inside the capsule. And also, the amount of bacteria that we use also is only one microliter. And so, imagine one microliter of bacteria producing a tiny amount of light. Finally, the electronics need to be able to read it. So that has been also part of the challenge. In this case, you have 4 different channels. One is a reference, and then the other 3 are the molecule of your choice. So, for example, what we show in the paper here is that we can even follow a metabolic pathway. So, you can see one more molecule turn into the other one, then into the other one. I'm really excited about that. Because normally we kind of guess as things are happening, you know, but here you can see in real time how the different molecules are changing over time. I think that's pretty exciting for microbiologist. The immediate application would be for a follow up. Let's say the patient is going to have a flare, and so you could predict it more much earlier. Or there's a particular treatment, and you want to see what is happening [inside the gut]. But for me, as a microbiologist, one of the things I'm most excited about will be more in the longer term. One of my favorite experiments that I do with the students is the Winogradsky column, and everyone gets super excited. So, we all have nice feelings for that. And it's basically a column where we asked the students to bring mud from a lake, for example, and then some sources of nutrients. And then, after 6months, you will see all the layers, which is super pretty—beautiful, nice colors. But actually, that gives the concept of how the microenvironment helps to define where, or how, bacteria build communities. And so, what I think this device is going to do is to help us identify what is this microenvironment and to characterize that. And then, from there, to know if [an individual's] microbiome is leaning towards the disease state, or if it's already in a serious or dangerous situation, to think about treatments that can lead to a more healthy state. So, I would just say it's really to have a window into the gut, and to be able to give personalized treatment for the patient. So, one application: I was thinking, I'm from the Boston area. So, one problem we have is getting a tick bite, right? After that, you could actually have to go through a very traumatic, antibiotic regime. I would imagine, in that case, you could [use the biosensor to] get the baseline [measurement], and then if you need to take these antibiotics, the doctors can follow how your microbiome is responding to that. Because one of the problems is that antibiotics changed the oxidation level [in the gut], and that really affects a lot the microbiome. To that point, for example, I get to know patients that they were athletes, and then, after antibiotic treatment, they have serious problems with obesity. Their life gets really messed up in many ways. And so, what I'm thinking is, if we could monitor earlier, there are a lot of ways that we could prevent that. We could give antioxidants; we could change the antibiotic. There are things that I think the doctor could be able to do and still do the treatment that we know. And of course, [although] we talk a lot about how much trouble antibiotics are, for certain things, we still need [them]. [The multi-diagnostic diaper] is one of my pet projects. I really love it. So yeah, basically, the issue is that the microbiome develops in the first 3 years. People even say like, 1000 days, you know. But there's really no way to monitor that. And now we're seeing that actually, if the microbiome gets affected, there are a lot of diseases that you will see in adult life. So, if we will be able to monitor the microbiome development, I really believe that we'll be able to prevent many of the diseases of tomorrow. What happens is that babies wear diapers. So, I thought it was really a very good overlap. We call that “wearables,” you know, like devices that you can wear, and then from there, measure something connected with health. So, in the diaper, I was excited because—different from the challenge with the ingested device, which was so tiny—here, we don't have the limitation of space. So, we could measure maybe 1000 different biomarkers and see how that builds over time. We can measure so many things. One could be just toxic elements that could be in the environment. I try to do very grounded science, and so, my question is always, ‘what's the actionable thing to do?' So, I'm thinking if there was a lot of toxicity, for example, in the carpet, or in the environment where you live, those are the easiest things to change, right? Then also, other things connecting more with the metabolism. [Often] the parents don't know that the kid has metabolic issues. So, before that starts to build and bring disease, it would be best if you could detect it as early as possible. From there, with symbiotics, we are thinking there are a lot of therapies that could engineer bacteria to produce the enzymes that the kid can't produce. We could also [develop] other products, like for example, a t-shirt to measure the sweat. I'm also thinking more of the milk. I'm very excited about how the milk helps to build the microbiome in the right way. And that that's a huge, very exciting area for microbiologists. And so, we could also have nursing pads that also measure [whether] the mother has the right nutrients. My family, my grandparents were farmers, and in Argentina, really the time for harvest is very important. You can see how the city and really the whole country gets very active. And at that time [during a course Inda-Webb was taking at Cold Spring Harbor] in this course, I could see that with yeast we were having a lot of tools that would allow us to be much more productive in the field. And I thought, ‘Oh, this feels like a harvest system for yeast.' Yes. So that was how it [Inda-Webb's winning agar artwork, ‘Harvest System'] came out. I really love the people. Here, [at ASM Microbe 2023], I really found that how people are bringing so much energy and really wanted to engage and understand and just connect to this idea of human flourishing, right, giving value to something, and saying, ‘okay, we can actually push the limits of what we know.' How beautiful is that? And you know, we can learn from that. That was very exciting. ASM Agar Art Contest Have you ever seen art created in a petri dish using living, growing microorganisms? That's agar art! ASM's annual Agar Art Contest is a chance for you to use science to show off your creative skills. Submissions Are Now Being Accepted! This year's contest theme is "Microbiology in Space." Head over to our Contest Details page to get all of the information about what you need to submit your entry. Submissions will be accepted until Oct. 28! Links for the Episode: Inda-Webb, et al. recent Nature publication: Sub-1.4 cm3 capsule for detecting labile inflammatory biomarkers in situ. Bacterial Biosensors: The Future of Analyte Detection. Let us know what you thought about this episode by tweeting at us @ASMicrobiology or leaving a comment on facebook.com/asmfan.

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George Lindsay on Preserving Oyster Bay's Marine Heritage

Flanigan's Eco-Logic

Play Episode Listen Later Aug 28, 2023 31:32

In this episode of Flanigan's Eco-Logic, Ted speaks with George Lindsay, Jr., President of the Christeen Oyster Sloop Preservation Corp, a non-profit in Oyster Bay, Long Island with the mission of preserving Oyster Bay's Marine Heritage by involving the community in traditional boat building. He also serves on the boards of the Atlantic Class One Design Association, Camp DeWolfe, Concerts By The Pond, and the Long Island Traditional Music Association.George is a lifelong resident of Oyster Bay and Cold Spring Harbor, New York. He studied theater at Harvard College and the Yale School of Drama, and retired in 2017 after thirty four years as General Manager of Tilles Center for the Performing Arts at Long Island University. He is an avid sailor and, with his wife, Nancy Metz, enjoys folk music and dancing, and traveling to visit their three children and two grandchildren.He and Ted discuss the launch of the Ida May, the first diesel powered oyster-dredging ship, which he rebuilt from scratch with other community members. They also discuss the health benefits of oysters, the history and preservation of oysters in Oyster Bay, and the future of Oyster farming.

How Long Island became the ‘eugenics capital of the world'

Color Code

Play Episode Listen Later Aug 14, 2023 34:14

Early geneticists were convinced they could use genetics to reshape society to their ideals and believed that the human race could be improved through selective breeding. An early seat for eugenics in the U.S. was Cold Spring Harbor Laboratory on Long Island. As the lab's influence began to extend to the halls of Congress, the Supreme Court, and internationally, Cold Spring Harbor became known as the eugenics capital of the world.

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Risa Gold MD, DLFAPA, President, Miracle of Help, A DotCom Magazine Interview

The DotCom Magazine Entrepreneur Spotlight

Play Episode Listen Later Jul 21, 2023 40:15

About Risa Gold MD and Miracle of Help: Risa Gold MD, DLFAPA is a board-certified Child & Adolescent Psychiatrist in Cold Spring Harbor, NY. She graduated Cum Laude from Harvard, and earned her medical degree from Columbia University College of Physicians and Surgeons. Dr. Gold completed a residency in Psychiatry at Payne Whitney Clinic, New York Hospital, Cornell and a Fellowship in Child Adolescence Psychiatry at North Shore University Hospital. After serving as the President of the Greater Long Island Psychiatric Society, Dr. Gold was awarded Distinguished Life Fellow of the American Psychiatric Association. Dr. Gold has been in private practice since 1987. After her son returned from a medical service outreach trip in Sierra Leone, he alerted her to the pressing need for health care services in these remote and vulnerable villages. Dr. Gold started MOH USA, Inc to raise funds for a community-led project that would comprise a hospital complex and several small businesses to support it. She is married to Dr. Kenneth Gold & has raised four children. Miracle of Help is a 501(c)(3) charitable nonprofit using a community-led development model to help communities mobilize and design solutions that address their overall social and healthcare needs. Sierra Leone has the second highest infant mortality rate in the world. Inspired by firsthand accounts of the poverty and lack of medical services for pregnant women in eastern Sierra Leone, Miracle of Help (MOH) is helping the community build a Maternal Child Health Post (MCHP), for safe childbirth and pre- and post-natal care. The center is located in the village of Ngolahun, a village of slightly over 2,000 people, with no electricity or running water. Four smaller villages within walking distance (total population 2,000) will also receive services from the MCHP. During our monthly pop-up clinics our doctors have diagnosed some form of malnutrition in 80% of the children they see (see photos). As of the end of May 2022, we established two malnutrition clinics for severe and moderate acute malnutrition for children under the age of five. Our staff was trained by clinicians from Project Peanut Butter & Partners in Health, and both clinics have been certified by the Sierra Leone government. Since the inception of the clinics, twenty-five children have been rescued from malnutrition and their mothers given jobs selling soap to support them. Currently, twenty-seven children are enrolled in the two clinics. The mothers learn how to make Bennimix (provided by MOH), a blend of nutritive food substances to feed their children. Miracle of Help's fundraising efforts to establish a safe birthing center / women's health clinic in Sierra Leone were recognized by Ambassador Dr. Francis Kaikai at the Consulate of Sierra Leone in NY city, December 3, 2018. Ambassador Dr. Francis Kaikai appears in the center of this photo along with the Board of Directors of Miracle of Help.

Billy Joel: Cold spring Harbor

Radio Duna - Sintonía Crónica

Play Episode Listen Later Jul 3, 2023

billy joel cold spring harbor

Tasting Wines & Toasting Women at Wölffer Estate Vineyard

Long Island Tea

Play Episode Listen Later Mar 14, 2023 44:02

-Today on Long Island Tea, Sharon and producer Alyssa are out tasting wines at the beautiful Wölffer Estate Vineyard on the South Fork in Sagaponack. The ladies try some incredible wines with Vanessa Karali, Director Of Hospitality at the vineyard, who shares her knowledge of the vineyard, the grapes, the wines, and everything this breathtaking property has to offer. And March 24- April 2, Long Island Wine Country has some fantastic deals for LI locals only. Long Island locals can enjoy VIP treatment, special tours, and exclusive discounts.After the tasting, the ladies talk #LongIslandLife with partners and events, share some of their favorite cocktails for National Cocktail day, and give tribute to some badass Long Island women as we continue to celebrate Women's History Month#LONGISLANDLIFE:Wölffer Estate vineyardhttps://www.wolffer.com/LL Locals Event details:https://liwines.com/liwc-locals/ LONG ISLAND EVENTS:3/16: Against the Grain: A Women's History Walking Tour - The Ward Melville Heritage Organization3/16: Long Island Stage: Soft Rock - The Suffolk3/16: The Rescue Effect: The Key to Saving Life on Earth - Vanderbilt Museum & Reichert Planetarium3/17: St. Patrick's Fundraiser for Local Fire Department - The Mansion at Glen Cove3/17: Beyond Van Gogh: The Immersive Experience - Westbury3/17: Wine Maker Dinner at Preston House with McCall Wines3/17: St. Patrick's Day Party at Montauk Distilling Co.3/18: Hampton Bays St Patrick's Day Parade3/18: Cold Spring Harbor's First Annual St. Patrick's Day Treasure Hunt3/18: Treasure Hunt at Connetquot River State Park3/18: LI Tabletop Gaming Expo at Cradle of Aviation3/19 Babylon St. Patrick's Day Parade3/19: 2023 Glen Cove Saint Patrick's Day Parade3/19: Selfie Club House - Royal Princess Party 3/19: Long Island Explorium - Brain Awareness Day ASK US ANYTHING!DM us on Instagram or email us at spillthetea@discoverlongisland.com. Tell us what you want to hear! Whether it is Long Island related or not, the ladies are here to spill some tea with you!TAG US!@DiscoverLongIsland and @LongIslandTeaPodcast and join the conversation!WINE OF THE WEEK:Wölffer Estate Vineyards tasting:- Spring in a Bottle (non-alcoholic, dry rosé sparkling wine)- Summer in a Bottle Côtes de Provence Rosé- Trebbiano, a Cellar Series Wine- Fatalis Fatum, a Wölffer White Horse SelectionLong Island Tea is sponsored by Long Island Wine Country. Visit https://liwines.com/TEA TIME:Check out our Amazon Affiliate link:www.amazon.com/shop/discoverlongislandWATCH US:And SUBSCRIBE on YouTubehttps://www.youtube.com/DiscoverLongIslandNYFOLLOW US:Follow The Long Island Tea podcast on Facebook, Instagram, and Twitter @LongIslandTeaPodcastWRITE TO US:Email spillthetea@discoverlongisland.com if you are interested in collaborating with us, need some "uncorked advice"or if you just want to say “How you doin?”RATE AND REVIEW US:Be sure to leave us a 5 star rating and review on Apple podcasts: https://podcasts.apple.com/us/podcast/long-island-tea/id1538642018WEAR US:Shop Long Island gear at https://shop.discoverlongisland.com Hosted on Acast. See acast.com/privacy for more information.

Spotlight On Long Island Schools - Cold Spring Harbor District 4-29-23

How'd You Think of That? with Temple Grandin

Play Episode Listen Later Mar 13, 2023 22:27

Spotlight On Long Island Schools - Cold Spring Harbor District 4-29-23 by JVC Broadcasting

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The Sense of Science: Temple Grandin and Dave Miklos

Play Episode Listen Later Feb 13, 2023 22:46

Miklos is the Executive Director of the Dolan DNA Learning Center at Cold Spring Harbor. He started his career in education by teaching high school teachers to clone genes and started the Learning Center in 1988. His book DNA Science was published in 1990 and he won the Charles A. Dana Award. Now he blends his worlds of biology, journalism, education and the social sciences to design modern DNA experiments for teachers, parents and young people.

Turn Around

acast turnaround cold spring harbor

Play Episode Listen Later Jan 31, 2023 29:27

Turn Around kicks off the second side of Billy's first album, Cold Spring Harbor, and when I say, "kicks off" that may be the wrong way to use the term. It is the only song on the album to feature Sneaky Pete Kleinow -- who? Exactly. Although he created the theme song for an epic show just before he recorded this. So -- good trivia today. Hosted on Acast. See acast.com/privacy for more information.

Taproot S6E4: Can We Force Academic Structures to be Inclusive?

The Taproot

Play Episode Listen Later Jan 17, 2023 42:22

In this episode, we speak with Jason Williams, Assistant Director of Inclusion and Research Readiness at the DNA Learning Center at Cold Spring Harbor Laboratory. Jason is also lead for CyVerse Education, Outreach, and Training – the U.S. National Cyberinfrastructure for Life Science. Jason received his B.S. in Biology from SUNY Stonybrook in 2004, then worked as a technician in several labs at Cold Spring Harbor, and then transitioned to multiple roles in the DNA Learning Center In 2009. We discuss an article Jason and colleagues recently published in Science, entitled “Achieving STEM diversity: Fix the classrooms. Outdated teaching methods amount to discrimination”. We also talk about the nuance and complexities around improving diversity, equity and inclusion in STEM education, in planning conferences, and in running scientific societies. Have a listen! Show Notes: Paper: J. Handelsman, S. Elgin, M. Estrada, S. Hays, T. Johnson, S. Miller, V. Mingo, C. Schaffer, and J. Williams. (2022). Science 376:1057-1059. https://pubmed.ncbi.nlm.nih.gov/35653460/ Twitter Handles Liz Haswell Twitter @ehaswell Ivan Baxter Twitter @baxtertwi Jason Williams Twitter @JasonWilliamsNY

Monsters & Spooky Stories (From the Long Island Monster Gallery)

Long Island Tea

Play Episode Listen Later Oct 25, 2022 49:14

Special Episode! We are on location from the Long Island Monster Gallery , an art gallery dedicated to horror cinema featuring two floors of life-size monsters., This walk through attraction is a must-see! AND *** Giveaway Alert***we are giving away a pair of tickets on our Instagram so be on the look out to enter for your chance to win. It's the perfect setting for some spooky stories which Kristen and Sharon share later in the show. Plus some unique local Haunted Houses and Haunted Car washes. As well as other Halloween attractions and events going on this weekend. Today the ladies are sipping on Paumonok Festival red for WOTW. They also talk about adult happy meals, why Gen Z hate emojis, and spilling some celebritea! Long Island Monster Gallery:https://www.longislandmonstergallery.com#LONGISLANDLIFE10/27: Lucky To Live Here Witches Night Out in Cold Spring Harbor: https://www.luckytolivehererealty.com/blog/Cold-Spring-Harbor-Witches-Night-Out10/28-10/30: Wildplay Halloween Zipline Pumpkin Toss – All Day: https://www.wildplay.com/jones-beach10/28 Family Spooky Science Night – Cradle of Aviation: https://www.cradleofaviation.org/plan_your_visit/event_calendar.html/event/2022/10/28/spooky-science-night/40039310/28-10/29 “We Put A Spell on You” – CM Performing Arts: https://cmpac.com10/28-10/30 Spooky Fest at Center for Science Teaching and Learning: https://www.cstl.org/spooky-fest/10/28 Montauk Distilling Company Costume Contest: https://montaukdistillingco.com/events/10/29: Bats Barnacles and Broom Sticks Halloween Party at LI Aquarium https://www.longislandaquarium.com/bats-barnacles-broomsticks-halloween-celebration/10/29: Hallockville Trunk or Treat https://hallockville.org/events/trunk-or-treat-event/10/29: Raynham Hall Halloween Ghost Walk and Dance Party https://raynhamhallmuseum.org/events2/halloween-ghost-walk-dance-party/10/29: Great Jack O'Lantern Spectacular Sail – Belmont Lake State Park https://parks.ny.gov/events/event.aspx?e=88-33632.010/29 Mulchay's Halloween Party https://muls.com/event/halloween-party-210/29: Murder Mystery Theater at Planting Field https://plantingfields.org/happenings/murder-mystery-theater/10/29: Halloween Party with DJ Chilly – Claudios https://claudios.com/event/halloween-party-with-dj-chilly/10/29: Monster Smash at The Church Sag Habror https://www.thechurchsagharbor.org10/30: Old Westbury Gardens – Fall Dog Parade & Costume Contest https://www.oldwestburygardens.org/2022-calendar-of-events10/30 Six Harbors Brewing Dog Party & Parade https://sixharborsbrewingcompany.com/event/halloween-dog-costume-party-and-parade/Blog: Haunted Long Island: Paranormal Experiences & Spooky Historic Sites https://www.discoverlongisland.com/best-haunted-sites-to-visit-on-long-island-ny/WINE OF THE WEEK:Paumonok Festival Red a classic Bordeaux-style blend of Cabernet Franc and Merlot; with a complex palate of herbs, oak, cedar, and red fruits, this wine is alovely match for grilled meats. Long Island Tea is sponsored by Long Island Wine Country. https://liwines.com/WATCH US:And SUBSCRIBE on YouTube https://www.youtube.com/DiscoverLongIslandNY FOLLOW US:Instagram: https://www.instagram.com/longislandteapodcast/Facebook: https://www.facebook.com/Long-Island-Tea-Podcast-101538728517461Twitter: https://twitter.com/longislandteapodcast WRITE TO US: Email spillthetea@discoverlongisland.comRATE AND REVIEW US: https://podcasts.apple.com/us/podcast/long-island-tea/id1538642018 Hosted on Acast. See acast.com/privacy for more information.

Episode 80 | Lisa Torem ["Billy Joel: Every Album, Every Song]

Booked On Rock with Eric Senich

Play Episode Listen Later Sep 1, 2022 73:45

‘In the beginning,' Billy Joel entertained Long Island locals, with The Hassles and Attila, prior to forging a solo career in 1971. One year later, the singer-songwriter-pianist captivated college students when “Captain Jack” dominated the Philadelphia airwaves. ‘And so, it goes…' ‘Cold Spring Harbor' was rife with barrelhouse piano and tear-stained balladry but with ‘Turnstiles' Joel realized his dream of forming a stellar band. The success of ‘The Stranger' led to sold-out arenas and ‘52nd Street' honored the heyday of American jazz, while ‘The Nylon Curtain' highlighted socio-economic inequities and wartime brotherhood. 1993's ‘River of Dreams' fused reggae and world music. Then, in the early 2000's, his celebration of classical works ushered in a sea change. Unquestionably, Billy's catalogue has thrived, despite constantly changing trends in the music industry. Over a fifty-plus year span, many of his relatable songs have become standards, covered by countless artists. The third best-selling solo artist in the U.S. has continued to attract multi-generational audiences across the planet, so if you're ‘all in the mood for a melody,' read on. As part of Sonicbond's On Track series, “Billy Joel Every Album, Every Song” contains behind-the-scenes stories and an analysis of Joel's extensive studio recordings, many of which became top 40 hits in the 1970s, 1980s and 1990s. The book also features a foreward by legendary Billy Joel drummer Liberty DeVitto.Rock journalist Lisa Torem has written features, profiles and reviews for American and British outlets for over a decade, and has interviewed Ian Anderson, Colin Blunstone, Eric Burdon, Dave Brubeck, Dave Davies, Janis Ian, Buffy Sainte-Marie, Sarah McLachlan, Robin Trower, Suzanne Vega, Dweezil Zappa among others. She co-authored “Through the Eye of the Tiger” with Survivor's Jim Peterik in 2014 and “All That Glitters” with vocalist Ava Cherry in early 2022.Purchase a copy of "Billy Joel: Every Album, Every Song" in the UK through Burning Shed: https://burningshed.com/lisa-torem_billy-joel-on-track_bookPurchase a copy of "Billy Joel: Every Album, Every Song" in the US through Amazon: www.amazon.com/dp/1789521831/Listen to a playlist of the music discussed in this episode: https://open.spotify.com/playlist/78ncIeq4uBzxoBwYFeSt40?si=bbe7010b260f486cListen to “Wonder Woman” by Billy Joel's early band Attila: www.youtube.com/watch?v=sWvjb4I8lIYFollow Lisa Torem:Twitter: https://twitter.com/lisatoremFacebook: www.facebook.com/lisa.toremInstagram: www.instagram.com/lisatoremThe Booked On Rock Website: www.bookedonrock.comFollow The Booked On Rock with Eric Senich:FACEBOOK: www.facebook.com/bookedonrockpodcastTWITTER: https://twitter.com/bookedonrockINSTAGRAM: www.instagram.com/bookedonrockpodcast/?hl=enSupport Your Local Bookstore! Find your nearest independent bookstore here: www.indiebound.org/indie-store-finderContact The Booked On Rock Podcast:thebookedonrockpodcast@gmail.comThe Booked On Rock Music: “Whoosh” & “Nasty” by Crowander (www.crowander.com)

SHE'S GOT A WAY

FRANCO CIANFLONE MUSIC IS LIFE PODCAST

Play Episode Listen Later Jul 1, 2022 3:22

Words and Music by Billy Joel 1971Billy Joel Official YouTube Channelhttps://www.youtube.com/channel/UCyVo..."She's Got a Way" is a song by American singer-songwriter Billy Joel, originally released on his first studio album, Cold Spring Harbor (1971) and as a single from that album in some countries. (Wikipedia)PhotoMadison Square Garden New York 4/8/22These selections and arrangements are for your listening pleasure only and not intended for any other purpose.Cover by Franco Cianflone at GS studios Hosted on Acast. See acast.com/privacy for more information.

music american acast billy joel gs cold spring harbor

Prof. David Bisaha on Millia Davenport - Crossroads of Rockland History

Crossroads of Rockland History

Play Episode Listen Later Jun 20, 2022 30:18

Episode originally aired on Monday, June 20, 2022, at 9:30am, on WRCR 1700AMWe turned our attention to the life and legacy of Millia Davenport. David Bisaha, Assistant Professor of Theater at SUNY Binghamton joined host Clare Sheridan to discuss this remarkable and trailblazing woman who lived most of her life in Rockland County. Among her many contributions include writing the definitive book of theatrical costume history, The Book of Costume. Published in 1948, it remains the gold standard. (Royalties from the book were donated to the New City Library.)Born in Cambridge, Massachusetts, on March 31, 1895, to Charles B. and Gertrude Crotty Davenport, Millia Davenport lived in New City for more than 70 years. Her father and mother were biology teachers at Harvard and Radcliffe, respectively. They were genetic researchers and helped establish the Station for Experimental Evolution of the Carnegie Institute of Washington in Cold Spring Harbor, NY.After attending Barnard and Parsons, Millia Davenport created artwork for and edited The Quill, a literary magazine. Later, she became one of the first female scenic design painters in America. She worked as a costume designer for a number of Broadway theater companies, including Maxwell Anderson's Playwrights Company and Orson Welles's Mercury Theater.In 1981, she received an honorary doctorate in fine arts from the Parsons School of Design in Manhattan the same year that she received the highest honor given by the United States Institute for Theatre Technology for a lifetime of distinguished contribution to the performing arts. In 1991 the Costume Society of America established the Millia Davenport Publication Award recognizing excellence in costume scholarship.Davenport died in 1992.David Bisaha is a scholar and practitioner who studies performance design, theatrical space and architecture, and the history of theatrical creativity. He is an Assistant Professor in the Department of Theater at SUNY Binghamton. He specializes in the history of scenic design in the United States, mostly in the first half of the twentieth century, and in the more recent history of immersive and participatory performance. His other research interests include theatre historiography, cognitive sciences and performance, directing theory, and memory studies.Bisaha's current book project, American Scenic Design and Freelance Professionalism, is a cultural labor history of scenic designers and designing in the United States. At Binghamton, Bisaha teaches theater and performance history, dramaturgy, and theater theory in the MA and BA programs. He is the Curator of the Theatre Collection of the Department of Theatre, and is affiliate faculty and a steering committee member of the Material and Visual Worlds Transdisciplinary Area of Excellence (TAE). The Millia Davenport papers are housed there.***Crossroads of Rockland History, a program of the Historical Society of Rockland County, airs on the third Monday of each month at 9:30 am, right after the morning show, on WRCR Radio 1700 AM and www.WRCR.com. Join host Clare Sheridan as we explore, celebrate, and learn about our local history, with different topics and guest speakers every month. We are pleased to announce that we have begun loading our archived podcasts to all major Podcast platforms.The Historical Society of Rockland County is a nonprofit educational institution and principal repository for original documents and artifacts relating to Rockland County. Its headquarters are a four-acre site featuring a history museum and the 1832 Jacob Blauvelt House in New City, New York.www.RocklandHistory.org

Average Joel's: Cold Spring Harbor

The Hoppy Boys

Play Episode Listen Later Jun 9, 2022 106:47

Long Island Lads Brian and Brendan start their journey into the vast discography of Billy Joel!!! Follow along with them as they break down every song from one of his 13 albums each week. All future episodes of this show will be released biweekly only on patreon.com/thehoppyboyspod Subscribe now to get the rest of this content!!

average billy joel cold spring harbor

She's Got a Way

new york religion microsoft exploring diving morris program managers dartmouth cognitive science fitness influencers neuroeconomics cold spring harbor

Play Episode Listen Later Jun 7, 2022 41:25

In 1971 the world got introduced to Gene Hackman, Willy Wonka and Dirty Harry and in November of that year that dude from the Hassles went solo and put out his first album as a singer songwriter, entitled “Cold Spring Harbor”. She's Got a Way is the first song from the first album anyone ever heard from Billy Joel and today we discuss the heck out of it. Billy re-recorded a live version of the song on his album Songs in the Attic so people could hear it without the chipmunk sound off Cold Spring Harbor and thank goodness for that. Unfortunately, it's another song about his ex-wife Elizabeth Webber so -- here we go again. But don't worry, on the next episode is "She's Right On Time" and that's a song about -- oh wait -- Elizabeth Webber. Oy. See acast.com/privacy for privacy and opt-out information.

songs willy wonka billy joel attic gene hackman oy dirty harry right on time hassles cold spring harbor elizabeth webber

S02E27 - Tales to Give You Goosebumps #3, Part 2

Say Podcast and Die!

Play Episode Listen Later May 16, 2022 72:59

Andy and Alyssa continue their discussion of Even More Tales to Give You Goosebumps (Special Edition #3) with "I'm Telling," "The Haunted House Game," "Change for the Strange," and "The Perfect School." Along the way, they discuss art contests, King Midas, turning to stone, Patrick Skene Catling's The Chocolate Touch, gargoyles (the creatures, the TV series, and the made-for-TV movie), Ghostbusters, the locus terribilis, games that play you, hellscapes, repetition compulsion, Shutter Island, not knowing you're dead, The Sixth Sense, Jumanji (1995), games as metaphors for trauma, ending at the beginning, S.E. Hinton's The Outsiders, Southbound, diverging adolescent interests, the Rainforest Cafe, doping, Mariko and Jillian Tamaki's This One Summer, lesbians and small businesses, "The White Gown" from Scary Stories to Tell in the Dark, cursed fashions, Animorphs, Ovid's Metamorphoses, Angela Carter's The Tiger's Bride, safe stories, ominous retail experiences, Lord Dunsany's "The Bureau d'Echange de Maux," Harlan Ellison's "Shoppe Keeper," William F. Wu's "Wong's Lost and Found Emporium," rigid parents, Cold Spring Harbor, The Stepford Wives, 28 Days Later, Karl Capek's R.U.R., Millennium, reform school, Louis Sachar's Holes, Karen Joy Fowler's "The Pelican Bar," Brian Evenson's "A Report," and the panopticon. // Music by Haunted Corpse // Follow @saypodanddie on Twitter and Instagram, and get in touch at saypodanddie@gmail.com

Dartmouth Microsoft and Fitness Influencer — Isabelle Morris D'21

DARTMOUTH STUDENTS

Play Episode Listen Later Apr 22, 2022 23:27

Diving deep into Microsoft and Fitness Influencer career advice with Dartmouth Alumni D'21 — Isabelle Morris. Exploring how she navigated her career at Dartmouth and how she entered the tech and fitness world. We examine her day-to-day and get insights into how she managed to be who she is today. Isabelle was born and raised in Cold Spring Harbor, New York before attending Dartmouth. She graduated in 2021, majoring in Cognitive Science with a focus in Neuroeconomics and a minor in Religion. Isabelle was also interested in the intersection between technology and human cognition, and she was involved in the DALI Lab at Dartmouth. After graduation, she became a Program Manager at Microsoft on the Azure Networking team. In addition to her academic pursuits, Isabelle has always been passionate about fitness and nutrition. She runs an Instagram account @fitness4lazygirls where she promotes a balanced approach to fitness and provides 1:1 online coaching for women who want to gain confidence without restrictions. We are so amped for this convo! Let's get into it... click play... We'll keep you on track with your life and your goals. It's time to go out there and grind and do something great! SUBSCRIBE you don't want to miss what we have coming next, see you soon Darties! --- Support this podcast: https://anchor.fm/behindthegreennn/support

Spotlight On Long Island Schools - Cold Spring Harbor District Threatre Arts Program 4 - 2 - 22

Play Episode Listen Later Mar 21, 2022 22:45

Spotlight On Long Island Schools - Cold Spring Harbor District Threatre Arts Program 4 - 2 - 22 by JVC Broadcasting

schools long island arts program cold spring harbor jvc broadcasting

Spotlight On Long Island Schools - Cold Spring Harbor District Westside Elementary 3 - 26 - 22

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Play Episode Listen Later Mar 18, 2022 22:44

Spotlight On Long Island Schools - Cold Spring Harbor District Westside Elementary 3 - 26 - 22 by JVC Broadcasting

schools long island elementary westside cold spring harbor jvc broadcasting

22. What is Alzheimer's Disease?

Orders of Magnitude

Play Episode Listen Later Mar 14, 2022 44:55

This week, we delve into the most common neurodegenerative disease: Alzheimer's. References: Stats on AD and Dementia: Monica Moore, M. S. G., Mirella Díaz-Santos, and Keith Vossel. "Alzheimer's Association 2021 Facts and Figures Report." Diagnosis of AD using PET scan: Chételat, Gaël, et al. "Amyloid-PET and 18F-FDG-PET in the diagnostic investigation of Alzheimer's disease and other dementias." The Lancet Neurology 19.11 (2020): 951-962. Amyloid Beta, the genetics of AD. Tanzi, Rudolph E. "The genetics of Alzheimer disease." Cold Spring Harbor perspectives in medicine 2.10 (2012): a006296. APOE risk factor. Raber, Jacob, Yadong Huang, and J. Wesson Ashford. "ApoE genotype accounts for the vast majority of AD risk and AD pathology." Neurobiology of aging 25.5 (2004): 641-650. Tau in Alzheimer's. Maccioni, Ricardo B., et al. "The revitalized tau hypothesis on Alzheimer's disease." Archives of medical research 41.3 (2010): 226-231.

Only A Man

man billy joel piano man good die young cold spring harbor

Play Episode Listen Later Mar 10, 2022 25:43

Uh oh, another song you've never heard of BUT, it's a good one. Only a Man was recorded in between Cold Spring Harbor and Piano Man. Oh it's Beatlesesqe of course, but what Billy Joel song isn't (or so he says)? We think you'll like this song too, and if you don't -- our next episode is Only the Good Die Young and if you don't like that -- you're listening to the wrong podcast

Episode #97 - Gerard Miller - UVM Catamount & CFO at Hivecell

Next Shift - More Than A Hockey Podcast

Play Episode Listen Later Mar 7, 2022 46:27

This week on the Next Shift Hockey Podcast we are joined by Cold Spring Harbor, New York native, former Vermont Catamount, European, AHL, ECHL pro and current COO/CFO at Hivecell, Gerard Miller. Gerard has had a successful career on and off the ice and was nice enough to join us to share his perspective and tell us why he's passionate about helping players make the transition to their next career after hockey. Thanks for joining the show, Gerard Miller!

new york european cfo gerard ahl echl catamount cold spring harbor

Nocturne

billy joel nocturne definately cold spring harbor yipes

Play Episode Listen Later Mar 1, 2022 30:13

Nocturne is a beautiful instrumental song by Billy Joel and the 9th track on the album Cold Spring Harbor released November 1, 1971. You can actually find a bootleg version of this song with lyrics on YouTube and it may be one of the few songs in history where making it instrumental was DEFINATELY the way to go. Yipes!

The Cancer Moonshot: Increasing cancer survivorship for everyone

20-Minute Health Talk

Play Episode Listen Later Feb 23, 2022 23:51

With the goal of cutting cancer deaths in half by 2047, the White House's Cancer Moonshot initiative is pumping $1.8 billion into cancer research over the next seven years. Achieving this goal, however, will require clearing research hurdles — including the lack of diversity in clinical trials, say Richard Barakat, MD, and David Tuveson, MD, PhD. They discuss the exciting research being funded by the Moonshot initiative, describe efforts to improve and diversify clinical trial recruitment, and explain the fruitful collaboration between Northwell Health and Cold Spring Harbor. Chapters: 01:33 - What is the Cancer Moonshot? 02:16 - Replicating success, speed of Covid-19 vaccine development 03:46 - Allocating funds 06:41 - The pre-neoplasia project 09:48 - Pushing for greater access 11:23 - Cancer disparities, outcomes 12:55 - Community outreach is critical 14:25 - Commitment to cancer research 16:26 - Practice changing, paradigm shifting, policy making 19:30 - Can we cut mortality by 50 percent? Meet the experts Richard Barakat, MD, Physician-in-Chief and Director of Cancer, Northwell Cancer Institute David Tuveson, MD, PhD, Professor, Director, Cancer Center, Cold Spring Harbor Watch episodes of 20-Minute Health Talk on YouTube.

1: Cold Spring Harbor

Bottle of White, Bottle of Red

Play Episode Listen Later Feb 12, 2022 71:47

Bill and Cory talk Billy Joel's storied debut album "Cold Spring Harbor" and pair wines to fit it. _______

billy joel voiceover cold spring harbor

Billy Joel – "Songs In The Attic"

SWR1 Meilensteine - Alben die Geschichte machten

Play Episode Listen Later Jan 24, 2022 42:44

Für sein Livealbum "Songs In The Attic" steigt Billy Joel unters Dach und holt tolle alte Songs raus, um sie Live auf der Bühne zu präsentieren. Aufgenommen im Sommer 1980 in acht unterschiedlichen Locations in den USA. Elf Songs sind es insgesamt geworden, darunter natürlich auch Aufzeichnungen aus seinem "Wohnzimmer", dem Madison Square Garden in New York. Indem gibt Billy Joel bis heute regelmäßig Konzerte für mehr als 20.000 Leute. Und die Shows sind immer ausverkauft – jeden Monat, wenn er dieses Konzert gibt. 1981 wurde das Live Album veröffentlicht. Es ist übrigens das erste Livekonzert, dass komplett digital aufgezeichnet wurde – und es klingt großartig. Obwohl die CD als neues Medium sehr stark angenommen wurde von den Musikfans und ja auch die Musikverkäufe der nächsten Jahrzehnte hauptsächlich übernehmen sollte, wurde "Songs In The Attic" auch noch mal auf Vinyl gepresst. Auf dem Livealbum "Songs In The Attic" wollte Billy Joel vor allem seine älteren Lieder präsentieren, einige auch von seinem Debütalbum "Cold Spring Harbor". So hatten mit dem Livealbum dann auch die neueren Fans eine Chance, sich endlich die Songs nach Hause zu holen, die erst später den Zugang zu seiner Musik fanden. Dieses Livealbum ist einfach so unglaublich energetisch, weil Billy Joel zu dem Zeitpunkt nicht mehr bei verschiedenen Konzerten unterschiedliche Livemusiker mit dabei hatte, sondern eine feste Liveband, zu der auch der legendäre Drummer Liberty DeVitto gehörte, welcher der ganzen Band einen Wahnsinns Drive verliehen hat. __________ Über diese Songs vom Album "Songs In The Attic" wird im Podcast gesprochen: 07:25 Mins – "Miami 2017 (Seen The Lights Go Out On Broadway)" 16:35 Mins – "Say Goodbye To Hollywood" 24:05 Mins – "Captain Jack" 32:01 Mins – "The Ballad Of Billy The Kid" 40:06 Mins – "I've Loved These Days" __________ Über diese Songs wird außerdem im Podcast gesprochen: 20:20 Mins – “Be My Baby” von The Ronettes 22:50 Mins – “Say Goodbye To Hollywood” von Ronnie Spector __________ Links zum Podcast: Englischsprachiger Wikipedia-Artikel mit Querverweisen zu den einzelnen Songs: https://en.wikipedia.org/wiki/Songs_in_the_Attic Deutscher Wikipedia-Artikel https://de.wikipedia.org/wiki/Songs_in_the_Attic Billy Joel sprich über „Songs In The Attic“ https://www.youtube.com/watch?v=7B1aioVR56w Billy Joels offizieller YouTube Kanal: https://www.youtube.com/channel/UCyVomykHKyWCWo8lSKHHmzA __________ Ihr wollt mehr Podcasts wie diesen? Abonniert die SWR1 Meilensteine! Fragen, Kritik, Anregungen? Schreibt uns an: meilensteine@swr.de

BI 125 Doris Tsao, Tony Zador, Blake Richards: NAISys

Brain Inspired

Play Episode Listen Later Jan 19, 2022 71:05

Support the show to get full episodes and join the Discord community. Doris, Tony, and Blake are the organizers for this year's NAISys conference, From Neuroscience to Artificially Intelligent Systems (NAISys), at Cold Spring Harbor. We discuss the conference itself, some history of the neuroscience and AI interface, their current research interests, and a handful of topics around evolution, innateness, development, learning, and the current and future prospects for using neuroscience to inspire new ideas in artificial intelligence. From Neuroscience to Artificially Intelligent Systems (NAISys).Doris:@doristsao.Tsao Lab.Unsupervised deep learning identifies semantic disentanglement in single inferotemporal face patch neurons.Tony:@TonyZador.Zador Lab.A Critique of Pure Learning: What Artificial Neural Networks can Learn from Animal Brains.Blake:@tyrell_turing.The Learning in Neural Circuits Lab.The functional specialization of visual cortex emerges from training parallel pathways with self-supervised predictive learning. 0:00 - Intro 4:16 - Tony Zador 5:38 - Doris Tsao 10:44 - Blake Richards 15:46 - Deductive, inductive, abductive inference 16:32 - NAISys 33:09 - Evolution, development, learning 38:23 - Learning: plasticity vs. dynamical structures 54:13 - Different kinds of understanding 1:03:05 - Do we understand evolution well enough? 1:04:03 - Neuro-AI fad? 1:06:26 - Are your problems bigger or smaller now?

learning ai evolution discord critique richards unsupervised deductive cold spring harbor zador

قريب ولا بعيد: عن علاقتنا مع الحيوانات

Maloom | Ù…Ø¹Ù„ÙˆÙ…

Play Episode Listen Later Nov 29, 2021 15:35

العلاقة التي تجمعنا مع الحيوانات غريبة بعض الشيء؛ بدأنا باصطيادها فقط، وواظبنا على ذلك رغم ما سببته من ضرر لنا. صرنا نربيها ونعيش معها جنبًا إلى جنب، رغم أن هذا القرب جعلنا معرضين للمزيد من الأمراض. كوفيد-19، والجدري، والأيدز، وغيرها. كيف انتقلت هذه الأمراض إلينا من الحيوانات؟ هذه الحلقة من بحث وكتابة بشر النجار، وتحرير عمر فارس، ومونتاج محمود أبو ندى، وتدقيق تالا مراغه، وتقديم سلام قطناني. في بودكاست «معلوم» تُبسّط سلام قطناني العلوم للإجابة على أسئلة هامّة عن أنفسنا والعالم والكون. بودكاست «معلوم» من إنتاج «صوت». بودكاست «معلوم» من إنتاج «صوت». المصادر: - Centers for Disease Control and Prevention, CDC. Zoonotic diseases. https://www.cdc.gov/ Web site. https://www.cdc.gov/onehealth/basics/zoonotic-diseases.html. Updated 2021. Accessed September, 2021. - Alizon S. C'est grave dr darwin? L'évolution, les microbes et nous. Le Seuil; 2016. - National Research Council. Sustaining global surveillance and response to emerging zoonotic diseases. 2010. - Levin S. Zoonoses. Goldman's Cecil Medicine. 2012:1964-1967. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151794/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151794/. doi: 10.1016/B978-1-4377-1604-7.00336-5. - Behbehani AM. The smallpox story: Life and death of an old disease. Microbiol Rev. 1983;47(4):455-509. https://pubmed.ncbi.nlm.nih.gov/6319980 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC281588/. doi: 10.1128/mr.47.4.455-509.1983. - Henderson DA, Inglesby TV, Bartlett JG, et al. Smallpox as a biological WeaponMedical and public health management. JAMA. 1999;281(22):2127-2137. https://doi.org/10.1001/jama.281.22.2127. Accessed 9/10/2021. doi: 10.1001/jama.281.22.2127. - Pan American Health Organization, (PAHO). Rabies in humans is 100% preventable but more than 55,000 people die each year . https://www.paho.org/en Web site. https://www3.paho.org/hq/index.php?option=com_content&view=article&id=251:2008-rabies-humans-100percent-preventable-but-more-than-55-000-people-die-each-year&Itemid=40264&lang=en. Updated 2008. Accessed September, 2021. - Sharp PM, Hahn BH. Origins of HIV and the AIDS pandemic. Cold Spring Harbor perspectives in medicine. 2011;1(1):a006841. https://pubmed.ncbi.nlm.nih.gov/22229120 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234451/. doi: 10.1101/cshperspect.a006841. - de Sousa JD, Müller V, Lemey P, Vandamme A. High GUD incidence in the early 20 century created a particularly permissive time window for the origin and initial spread of epidemic HIV strains. PloS one. 2010;5(4):e9936. https://pubmed.ncbi.nlm.nih.gov/20376191 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2848574/. doi: 10.1371/journal.pone.0009936. - Platto S, Zhou J, Wang Y, Wang H, Carafoli E. Biodiversity loss and COVID-19 pandemic: The role of bats in the origin and the spreading of the disease. Biochem Biophys Res Commun. 2021;538:2-13. Support the show: https://www.sowt.com/plus

Podcast - Kolagen

Podcast s Martinem Barnou

Play Episode Listen Later Nov 10, 2021 8:39

ZDROJE: RICARD-BLUM, Sylvie. The collagen family. Cold Spring Harbor perspectives in biology, 2011, 3.1: a004978. MAGIORKINIS, Emmanuil; BELOUKAS, Apostolos; DIAMANTIS, Aristidis. Scurvy: past, present and future. European journal of internal medicine, 2011, 22.2: 147-152. PAUL, Cristiana; LESER, Suzane; OESSER, Steffen. Significant amounts of functional collagen peptides can be incorporated in the diet while maintaining indispensable amino acid balance. Nutrients, 2019, 11.5: 1079. BENITO-RUIZ, P., et al. A randomized controlled trial on the efficacy and safety of a food ingredient, collagen hydrolysate, for improving joint comfort. International journal of food sciences and nutrition, 2009, 60.sup2: 99-113. AVILA RODRÍGUEZ, María Isabela; RODRIGUEZ BARROSO, Laura G.; SÁNCHEZ, Mirna Lorena. Collagen: A review on its sources and potential cosmetic applications. Journal of cosmetic dermatology, 2018, 17.1: 20-26. DE MIRANDA, Roseane B.; WEIMER, Patrícia; ROSSI, Rochele C. Effects of hydrolyzed collagen supplementation on skin aging: a systematic review and meta‐ International Journal of Dermatology, 2021. BOLKE, Liane, et al. A collagen supplement improves skin hydration, elasticity, roughness, and density: Results of a randomized, placebo-controlled, blind study. Nutrients, 2019, 11.10: 2494. INOUE, Naoki; SUGIHARA, Fumihito; WANG, Xuemin. Ingestion of bioactive collagen hydrolysates enhance facial skin moisture and elasticity and reduce facial ageing signs in a randomised double‐blind placebo‐controlled clinical study. Journal of the Science of Food and Agriculture, 2016, 96.12: 4077-4081. Collagen White Paper – Clean Label Project. Homepage – Clean Label Project [online]. Dostupné z: https://cleanlabelproject.org/collagen-white-paper/ ConsumerLab Reveals Best Collagen Supplements | ConsumerLab.com. Independent Tests and Reviews of Vitamin, Mineral, and Herbal Supplements |. Dostupné z: https://www.consumerlab.com/news/consumerlab-tests-reveal-best-collagen-supplements/10-04-2019/ Be Effective Audiokniha: https://www.audiolibrix.com/cs/Directory/Book/10360/Audiokniha-Jak-zhubnout-a-postavu-si-udrzet-Martin-Barna Videokurz: https://www.naucmese.cz/kurz/video-jak-zhubnout-a-postavu-si-udrzet-bez-jidelnicku-bez-suplementu-100-zaruka-spokojenosti Coaching - http://www.martinbarna.cz Objednávky kuchařky: barna@eftm.cz FB: https://www.facebook.com/martinbarnanutrition/ FB skupina pro Vás: https://www.facebook.com/groups/martinbarnanutrition IG: https://www.instagram.com/martinbarnanutrition/ Spotify: https://open.spotify.com/show/32zO7PDBAcHgyAfE6bK24d

EP 046 - Vinyl Box Set, Return to The Garden, Billy & Metallica in Vegas ...and more!

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Play Episode Listen Later Nov 9, 2021 64:34

Billy Joel released his first solo album, Cold Spring Harbor, in November 1971. Almost 50 years to the day, his fans are celebrating a string of exciting new announcements. In our most timely episode yet, we'll cover the latest developments in the Billy Joel world. On Friday, November 5, Billy brought his record-breaking residency back to Madison Square Garden after a nearly two-year hiatus due to the pandemic. Also on November 5, Billy released the Vinyl Collection, Vol. 1. It's a boxed set containing new masters of his first six studio albums, Songs in the Attic, and an unreleased concert from 1975. In the lead up to the box set, Billy also released a new animated video for Scenes From An Italian Restaurant. And, in an announcement that seemed tailor-made for our co host Michael, we learned that Billy and Metallica will soon play at the same venue on the same weekend in Las Vegas. It's a lot at once, and we're here to share in the excitement. Join us, as we dig deep, into the latest and greatest Billy Joel news. Check out our video unboxing of Billy Joel - The Vinyl Collection, Vol. 1 here: https://youtu.be/5oeIBm0kajo ------ Email us: glasshousespodcast@gmail.com Glass Houses - A Billy Joel Podcast on the web / social media: Website: http://www.glasshousespod.com Facebook: https://www.facebook.com/glasshousespodcast/ Instagram: https://www.instagram.com/glasshousespod/ Twitter: https://twitter.com/glasshousespod

Who the Hell is Gordon Gooding?

On Thursdays We Thrive

Play Episode Listen Later Oct 28, 2021 48:59

Sam and Liana invite Licensed Social Worker, Gordon Gooding, to share their exciting news on their new partnership! Gordon has been practicing therapy for over 25 years. He is the founder of 2 successful group practices, Gooding Wellness and Long Island Teletherapy, out of Cold Spring Harbor, NY. He has also been a school social worker for many years serving students in grades K-12. Gordon has helped normalize therapy and educate the community on how therapy can benefit anyone. In this episode Gordon, Liana, and Sam discuss the myths around therapy, such as needing to be "sick enough" to go to therapy, and the myth that we "should" handle our conflicts on own on. By the end of this episode, their message will help promise looking for a therapist and asking for help won't seem so scary. IG: @OnThursdaysWeThrive To connect via email: Thursdays@goodingwellness.com On Thursdays We Thrive Podcast is a partner of Long Island Teletherapy and Gooding Wellness LCSW-PC. To book a session with Liana or Sam, head to longislandteletherapy.com !

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Got to Begin Again

carpenter glass houses begin again cold spring harbor

Play Episode Listen Later Sep 17, 2021 33:41

Got to Begin Again is the tenth and final track that completes Billy's first album Cold Spring Harbor which was released on November 1, 1971 and, famously rereleased, in December of 1983. In this episode find out why certain songs on Glass Houses may sound like Carpenter's songs. Yes, the musical group. I know. A fascinating discovery in the world of what is Billy Joel A to Z. See acast.com/privacy for privacy and opt-out information.

Episode 254: Picking the Right Probiotic

Naturally Nourished

Play Episode Listen Later Aug 23, 2021 95:11

Are you totally confused by probiotics or not sure which one to choose? Want to ensure you are getting the best bang for your buck and that your probiotic is actually doing something? Curious about how to pulse your probiotics based on symptoms and season? Tune in to hear Ali and Becki go down the rabbit hole on strain-specific research and discuss what to look for in a probiotic, best formulas for desired clinical outcomes, and how to tell if a probiotic is good quality. In this episode, Ali and Becki go into detail on some of the most widely researched probiotic strains, from lactobacillus to bifidobacterium to saccharomyces boulardii and beyond. Learn about promising clinical outcomes from reduction of IBS and IBD pain, regulation of bowels post antibiotic, prevention of candida overgrowth, and yeast infection and UTI treatment. Plus we discuss thoughts on probiotics formulated with prebiotics as well as some of the new spore-based probiotics and share our current favorite cultured foods to get a daily dose of probiotics! Also in this episode: 12 Week Virtual Ketosis Program - Only $99 through 9/1! Episode 230: Dysbiosis through Disconnection Episode 198: So You're On an Antibiotic Episode 174: The Dysbiosis Disease Connection and Ali's Cleanse Episode 60: Dysbiosis and the Microbiome Episode 68: Supporting Your Immune System Naturally (Deep dive on ear infections & antibiotic use in kids) Episode 87: The Gut Brain Axis Episode 131: Candida and SIBO Deep Dive What is the Microbiome? The Role of Probiotics Probiotics and Immune Health Belkaid Y, Hand TW. 2014. Role of the microbiota in immunity and inflammation. Cell157: 121–141. https://doi.org/10.1016/j.cell.2014.03.011 Collins, N., & Belkaid, Y. (2018). Do the Microbiota Influence Vaccines and Protective Immunity to Pathogens? Engaging Our Endogenous Adjuvants. Cold Spring Harbor perspectives in biology, 10(2), a028860. https://doi.org/10.1101/cshperspect.a028860 Kim, C.H. (2018), Immune regulation by microbiome metabolites. Immunology, 154: 220-229. doi:10.1111/imm.12930 Pickard, J. M., Zeng, M. Y., Caruso, R., & Núñez, G. (2017). Gut microbiota: Role in pathogen colonization, immune responses, and inflammatory disease. Immunological reviews, 279(1), 70–89. https://doi.org/10.1111/imr.12567 What to Look for When Choosing a ProbioticID Guarantee Why We Don't Include Prebiotics in Our ProbioticsPhytofiber Strain Specific ResearchLactobacillus Acidophilus NCFMD'Souza, B., et al. (2015), ‘Randomized controlled trial of probiotics after colonoscopy'. ANZ Journal of Surgery, doi: 10.1111/ans.13225. Engelbrektson, A.L .et al., (2009). ‘Probiotics to minimize the disruption of faecal microbiota in healthy subjects undergoing antibiotic therapy'. Journal of Medical Microbiology, 58:663-670. Engelbrektson, A.L. et al., (2006). ‘Analysis of treatment effects on the microbial ecology of the gastrointestinal tract'. FEMS Microbiol. Ecol. 57:239-250. Faber S.E., (2003), ‘Comparison of probiotics with antibiotics to probiotics alone in treatment of diarrhea predominant IBS (D-IBS), alternating (A-IBS) and constipation (C-IBS) patients', Gastroenterology, 124(4):A687-A688. Faber, S.M., (2000). ‘Treatment of abnormal gut flora improves symptoms in patients with irritable bowel syndrome'. American Journal of Gastroenterology, 95(9):2533. Forssten, S., et al., (2014). ‘Influence of a probiotic mixture on antibiotic induced microbiota disturbances'. World Journal of Gastroenterology, 20(33):11878-85. Leyer, G.J., et al., (2009). ‘Probiotic Effects on Cold and Influenza-Like Symptom Incidence and Duration in Children'. Pediatrics; 124 (2): 172-179. Restore Baseline Probiotic Targeted Strength Probiotic - use code TARGETPRO18 for 18% off KidsBiotic How to Take Probiotics With Antibiotics Bifidobacterium lactis Bi-07Gobel et al., (2010). ‘Probiotics to young children with atopic dermatitis: A randomized placebo-controlled trial'. International Journal of Probiotics and Prebiotics, 5(2):53-59. Lammers, K.M., (2003). ‘Immunomodulatory effects of probiotic bacteria DNA: IL-1 and IL-10 response in human peripheral blood mononuclear cells'. FEMS Immunology and Medical Microbiology 38: 165-172. Leyer G.J. et al., (2009). ‘Probiotic effects on cold and influenza-like symptom incidences and duration in children'. Pediatrics, 124:72-179. Maneerat S. et al., (2013). ‘Consumption of Bifidobacterium lactis Bi-07 by healthy elderly adults enhances phagocytic activity of monocytes and granulocytes' J Nutr Sci.., 2(2):e44. Masco L. et al., (2004). ‘Polyphasic taxonomic analysis of Bifidobacterium animalis and Bifidobacterium lactis reveals relatedness at the subspecies level: reclassification of Bifidobacterium animalis subsp. Animalis subsp. nov. and Bifidobacterium lactis as Bifidobacterium animalis subsp. Lactis subsp. Nov'. Int. J. System. Evol. Microbiol., 54(4): 1137-1143. Lactobacillus PlantarumRebuild Spectrum Probiotic Post Surgical Protocol Saccharomyces BoulardiiAbbas Z. et al., (2014), ‘Cytokine and clinical response to Saccharomyces boulardii therapy in diarrhea-dominant irritable bowel syndrome: a randomized trial', Eur J Gastroenterol Hepatol, 26(6):630-9. Akil I. et al., (2006), ‘Influence of oral intake of Saccharomyces boulardii on Escherichia coli in enteric flora', Pediatr Nephrol, 21(6):807-10. Algin C., et al. (2005) ‘Effectiveness of Bombesin and Saccharomyces boulardii against the translocation of Candida albicans in the digestive tract in immunosuppressed rats'. Surgery Today, 35: 869. Bafutto M. et al., (2013), ‘Treatment of diarrhea-predominant irritable bowel syndrome with mesalazine and/or Saccharomyces boulardii',Arq Gastroenterol, 50(4):304-9. Berg R. et al., (1993), ‘Inhibition of Candida albicans translocation from the gastrointestinal tract of mice by oral administration of Saccharomcyes boulardii'. J. Infect. Dis. 168(5):1314-8. Billoo A.G. et al., (2006), ‘Role of a probiotic (Saccharomyces boulardii) in management and prevention of diarrhoea', World J Gastroenterol, 12(28):4557-60. Bin, Z., et al. (2015). The Efficacy of Saccharomyces boulardii CNCM I-745 in Addition to Standard Helicobacter pylori Eradication Treatment in Children. Pediatric Gastroenterology, Hepatology & Nutrition, 18(1), 17–22. Blehaut, H. et al., (1989) ‘Disposition kinetics of Saccharomyces boulardii in man and rat'. Biopharm Drug Dispos, 10: 353–364. Bruggencate T., (2015), ‘The effect of a multi-strain probiotic on the resistance toward Escherichia coli challenge in a randomized, placebo-controlled, double-blind intervention study'. European Journal of Clinical Nutrition, 69:385-391. Burande M.A., (2013), ‘Comparison of efficacy of Saccharomyces boulardii strain in the treatment of acute diarrhea in children: A prospective, single-blind, randomized controlled clinical trial', J Pharmacol Pharmacother, 4(3):205-8. Buts J. et al., (1993), ‘Saccharomyces boulardii for Clostridium difficile-Associated Enteropathies in Infants'. Journal of Pediatric Gastroenterology and Nutrition, 16:419-425. Lactobacillus rhamnosus & Lactobacillus reuteriAnukam et al., (2006), ‘Clinical study comparing probiotic Lactobacillus GR-1® and RC-14® with met*******ole vaginal gel to treat symptomatic bacterial vaginosis'. Microbes Infect.8(12-13):2772-6. Anukam K.C. et al., (2006), ‘Augmentation of antimicrobial met*******ole therapy of bacterial vaginosis with oral probiotic Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14: randomized, double-blind, placebo controlled trial'. Microbes Infect. 8(6): 1450-4. Anukam et al., (2009), ‘Oral use of probiotics as an adjunctive therapy to fluconazole in the treatment of yeast vaginitis: A study of Nigerian women in an outdoor clinic'. Microb. Ecol. Health Dis., 21(2):72-77. Beerepoot et al., (2012), ‘Lactobacilli vs antibiotics to prevent urinary tract infections: a randomized, double-blind, noninferiority trial in postmenopausal women'. Arch. Intern. Med., 172(9):704-12. Women's Flora Probiotic BacteriophagesGI Clean Up Probiotic Challenge Choosing the Right Probiotic Chart What About Soil Based Probiotics Favorite Probiotic Foods Sponsors for this Episode: This episode is sponsored by the Naturally Nourished supplement line: these pure, potent and effective formulas have been hand selected to deliver profound health benefits. We price our formulas 2-5% below market industry standard and competitors and guarantee that our products will always be third party assessed to ensure they are free of mold, toxins, contaminants, and contain the stated active ingredients in dosages noted. Use code ALI15 for 15% off your first Naturally Nourished Supplement Order! This episode is also sponsored by Santa Cruz Medicinals, makers of potent and affordable CBD with effective dosing. For more information check out www.scmedicinals.com and use code ALIMILLERRD for 15% off your order.

Falling of the Rain

epic rain falling will dave cold spring harbor

Play Episode Listen Later Aug 19, 2021 27:28

The fifth track and final song on side one of Billy's debut album Cold Spring Harbor released November 1, 1971. And, as we begin the F letters, after waiting so long for a song from Cold Spring Harbor, we go back to back this time with Falling in the Rain. Will Dave like this one as much as he liked Everybody Loves You Now? Billy is even known for mocking this one.

E's Wrap Up

Play Episode Listen Later Aug 17, 2021 27:57

A recap of the E's, a preview of the F's, plus listener feedback and rankings. Also, recapping Dave's first reaction listen to anything (amazingly) off Cold Spring Harbor. AND, of course reiterating how our E's guest, Dennis Blair, inspired the entire An Innocent Man album. See acast.com/privacy for privacy and opt-out information.

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Everybody Loves You Now

billy joel b side everybody loves z podcast cold spring harbor

Play Episode Listen Later Aug 10, 2021 29:14

The third track off of Billy's debut album Cold Spring Harbor and released as the B-Side to She's Got a Way in January of 1972. The Billy Joel A to Z Podcast's first song off of Cold Spring Harbor AND the song on the album that uses the title Cold Spring Harbor. AND, since I'm clearly trying to see how many times I can use Cold Spring Harbor in a sentence, now Billy Joel's worst nightmare, as he never wants to be reminded of this album. See acast.com/privacy for privacy and opt-out information.

December Song

song elon musk mash unreleased robert altman cold spring harbor

Play Episode Listen Later Jul 15, 2021 23:11

This is an UNRELEASED track from 1971 written for the Cold Spring Harbor album. There's also a discussion of whether legendary director Robert Altman's son actually wrote the theme from M*A*S*H at 13. Elon says it's true but Dave says no way and everyone's high. See acast.com/privacy for privacy and opt-out information.

Conversations with the Pioneers of Oncology: Dr. Larry Norton

Cancer Stories: The Art of Oncology

Play Episode Listen Later Apr 19, 2021 39:40

Dr. Hayes interviews Dr. Norton. TRANSCRIPT SPEAKER 1: The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement. [MUSIC PLAYING] DANIEL F. HAYES: Welcome to JCO's Cancer Stories, the Art of Oncology, brought to you by the ASCO Podcast Network, a collection of nine programs covering a range of educational and scientific content, and offering enriching insights into the world of cancer care. You can find all of the shows, including this one, at podcast.asco.org. [MUSIC PLAYING] Dr. Norton has stock and other ownership interest in Samus Therapeutics, Codagenix Inc, Martell Diagnostic, and Medaptive Health Inc. He's received honoraria from Context Therapeutics, Prime Oncology, the Sarah Lawrence Lecture, Context Advisory Board, Oncology Pioneer Science Lecture Series, Sermonix Pharmaceuticals, the Cold Spring Harbor advisory board, Codagenix, Agenus, and the Cold Spring Harbor external advisory board. He has served as a consultant or provided advice to Context Therapeutics, Prime Oncology, the Context Advisory Board, Oncology Pioneer Science Lecture, Martell Diagnostic, Sermonix, Codagenix, Agenus, Medaptive Health, and the Cold Springs Harbor Laboratories. He has received expense reimbursement for travel and accommodations from the Oncology Pioneer Science Lecture Series, the BCRP Programmatic Review Meeting, the Breast Cancer Research Foundation, the American Association of Cancer Research, and Cold Spring Harbor Laboratory. [MUSIC PLAYING] Today my guest on the podcast is Dr. Larry Norton. Dr. Norton has been instrumental in so many facets of oncology it's hard to go through, but particularly, in breast cancer, and especially related to applying mathematical models of cancer kinetics that he developed with Richard Simon at the National Cancer Institute, and applying them really, to dose density strategies for chemotherapy and breast cancer, which we'll discuss. Dr. Norton was raised in suburban New York. He received his undergraduate degree at Rochester University, his medical degree at the Columbia University College of Physicians and Scientists. And then he did his residency at Einstein Associated Hospitals in the Bronx. He then went on to complete a medical oncology fellowship at the National Cancer Institute from 1974 to 1976 and stayed there an extra year. And then he returned to New York and joined the faculty at Mount Sinai in 1977, where he stayed for about a decade. He then moved to Memorial Sloan Kettering, where I think most of us think he was born and raised and lived his whole life. He's held many positions there. And particularly, he was responsible for really building the breast medical oncology service and starting the Evelyn Lauder Breast Center. He now sits in the Norman S Seraphim-- did I pronounce that correctly, Dr. Norton? LARRY NORTON: Yes, you did. DANIEL F. HAYES: Chair in Clinical Oncology, he's authored over 450 peer reviewed papers. He's won too many awards for me to list, as have most of my guests on this program. But in particular, he's won the triple crown, in my opinion. And that's the Karnofsky, the McGuire, and the Bonnadonna awards. At least those of us in breast cancer would strive to win all three of those. And importantly to this series, he served as president of ASCO from 2001 to 2002, has served many roles at ASCO and has had a major footprint in where ASCO is today. Dr. Norton, welcome to our program. LARRY NORTON: Great pleasure to be here. Thank you, Dan. DANIEL F. HAYES: So we'll start with some of the origin stories. I know you weren't bit by a radioactive spider and got spidey powers. But I've known you for a long time. And I know, really, your first love was music and that you started out to be a professional musician. Can you give us some background? What were your instruments? I know you went to Rochester specifically to be in music. And feel more than free to do some name dropping, because I think some of the people in music are people we'd all recognize. LARRY NORTON: Well, I don't know whether that would be totally right. I've known a lot of people in music. My first love was music. I grew up in Long Island, was able to commute in with one bus and one subway to Greenwich Village in the '60s, which was, really, the hotbed of much of what was going on in music to this day. I didn't even realize it was a golden age. I remember all the giants, Bob Dylan, when he was a very young kid in town, in small coffee houses. But it was also in close proximity where a lot of the jazz scene was happening, and just to take the A Train would be very easy to get up into Harlem, where there's a lot of jazz things going on. Like a lot of kids growing up on Long Island, I had some musical education. I started off with the clarinet, went quickly into saxophone in terms of music. But I played a whole variety of instruments. Like everybody else, I play guitar. I played percussion. I played bongos behind beat poets and was very excited to be really part of that scene. I think one of the major turning points for me, actually, was the Vietnam War. Because like a lot of people of my generation, it did not seem to be reasonable war. And even McNamara wrote a book later saying, yep, sorry, it was a mistake. We were looking for things that could interest us and also help us serve our country in ways other than sacrificing our lives in Vietnam. That's how medicine got into my life. It seemed to be the right compromise. Fortunately, starting off in Rochester which had the Eastman School of Music, which was a great influence on me, and a fantastic school, and has evolved continuously to be an even better school now. It has a very active jazz program now, which didn't exist at that time. We had to do jazz on the sly, which was very easy to do, because there are a lot of jazz clubs in Rochester at that time. And it was really very easy to play jazz all night and then to play classical music all day. And that was totally, totally a great experience. We were young. We didn't have to sleep at all. But I hankered to get back into New York. When the opportunity arose to go to medical school, I was fortunately chosen to go to Columbia, where I actually was able to play music and at the same time go to the medical school. But after a while, as all of us in medicine know, it becomes all consuming. And so the medicine part of it just slipped. When it came to a lot of my friends from the old days up until the present day, very little performing, I've done a couple of benefits. I'll do the one namedrop with Elton John, because he's been so terrific at raising money for breast cancer research through the Breast Cancer Research Foundation. I had the great honor of being able to play with him twice-- DANIEL F. HAYES: How did you meet Elton John? I mean, it's not like you walk down the street and say, oh, hi, I'm Dan Hayes. LARRY NORTON: Mutual friends, mutual friends in the arts, basically, one of our closest friends, close friend of his, close friend of mine, someone named Ingrid Sischy was a fantastic writer and editor, very involved with Andy Warhol in the beginning, and then continued a career in art criticism and art writing. And she was a friend of everybody and a close friend of Elton's and a close friend of mine. And so I think she made the original introduction. And he's really been terrific. But the music is put aside, although I do play every day. I still keep that as a very important part of my zen escape from other stresses of life. Although, music itself has its own stresses. The good thing about jazz is improvisation. So it's an immediate feeling, no such thing as a wrong note. You hit a wrong note, and you play around it. And it becomes a right note. And so music is still a very important part of my life. DANIEL F. HAYES: That's terrific. Actually, I interviewed Hyman Muss a few weeks ago. And he and some others have introduced me to tying flies for fly fishing. And it's sort of the same thing. I can take 15 minutes and tie a fly. I'm not sure it looks like anything official-like. But it's not medicine for a while, and that's good. LARRY NORTON: Yeah, but medicine-- DANIEL F. HAYES: The other thing-- LARRY NORTON: I want to get back to this for a second, because I mean, DANIEL F. HAYES: Yeah. LARRY NORTON: It's not a separate thing. I mean, music and-- especially my early music education just taught me a lot that's really helped me in my career in medicine. I think it's very important for people to know. The talent for music is a talent to practice. Essentially, anybody who can speak can-- has enough control of tones that they can actually do something with music. I'm not sure how much is really inborn ability. I'm not sure there is such a thing as a talent in that regard. But some people can practice for long hours successfully. And some people can't. And I think that that's something that may be inborn. I don't know. I'll leave that to the developmental psychologists. But that is a very important trait, obviously, in medicine. You have to spend a long time studying. You have to learn a lot. You have to concentrate a lot. You have to be able to concentrate on individual patients, when you're taking care of them. And that's been very important, but it's also empathy. Music teaches you to feel what other people are feeling. You're not going to be a good musician unless you know how you're affecting your audience in a profound way. And you can sense when you're losing your audience, and you can change the direction you're going in. And when you hit something right, you can play it. And that ability to feel what other people are feeling, I think, is really essential to be a good clinician. And music teaches you that. I think arts in general teach you that. DANIEL F. HAYES: Actually, I hadn't thought about it. Do you think that your music and your mathematic leanings are tied together too? LARRY NORTON: There is a tendency for mathematicians to be musicians, not true quite vice versa. Although they are-- good musicians really are mathematicians. But they don't know it. A lot of people think math is the written equation, and it's not. It's a certain approach toward nature. Thinking in spatial ways, for me, thinking of shapes, and the way shapes form, the way shapes move over time and space, then you learn the tools for being able to write it down which is the actual mathematical notation. DANIEL F. HAYES: Yeah. LARRY NORTON: And the same thing with music, I mean, music isn't the notes on the page. I mean, that's a very poor reflection of what sounds you're making. It's the sounds. It's the sounds, and they go up and then down. That's spatial, and they go forward in time. And so they're temporal, and they have meaning. It's not just random sounds. They have meaning. They connect to each other, and they tell a story, as we say in the jazz world. And the notes are a poor reflection of that. Some of the best musicians I know can't read music. And as a matter of fact, it used to be said that if you want to be good jazz musician, you shouldn't learn to read. Because if you learn to read, you'll cheat. And you should be able to play by ear. And that's what's going to make you a better musician. So I think math and music are very closely aligned. You have a problem to solve, when you think about it, and in novel ways that are not verbal. And the non-verbal way of thinking in music and in math are very similar, I think. DANIEL F. HAYES: So let me segue onto how you changed paths. I know that it was-- I've heard you talk about it was a discussion with Dr. Ron Bloom, who I think has remained a good friend of yours, and then in association with Dr. Regelson at Roswell Park. Can you tell us about that? LARRY NORTON: Well, Ron got me-- I mean, Ron, great, great oncologist, retired now, and his wife Diane also very, very important in the cancer world through her leadership of organizations. They both went to University of Rochester same time I did. I was actually perplexed at the end of one semester. So both Ron and Diane were at the University of Rochester, the same I was. And I was perplexed at the end of one semester, because I had several opportunities to do things in the summer coming forward. One of which was very music oriented, and it was a very exciting possibility. But I was at that time considering a change in direction very strongly. Math was one of the things that was drawing me. The question, should I become a professional statistician? That was the course that was turning me on mostly at that time. I thought physics was an incredible art form and was intrigued to that. But I also had music that was drawing me. And also the question, of what could keep me helping people, and helping my nation, and keep me from necessarily bearing arms in Vietnam was a big concern. And I met Ron on the stairs of the Rush Rhees Library at the University of Rochester, a famous library, that by the way, has a famous ghost associated with it. That's a whole different story. He said that he had this unbelievably wonderful experience the previous summer by working at Roswell Park Memorial Institute in Buffalo, New York State Cancer Research Institute, particularly under a guy named William Regelson who was just totally inspirational to him. And that was one of his major motivations to spend his career in cancer medicine, which I didn't even know it. I had another connection to Bill Regelson is that my father and his father actually knew each other. Because they were in businesses that touched. His father ran a Catskills resort. And my father was a professional writer and travel editor at The New York Post. And so that there was that connection. So that when I relayed the story to my parents, they said, oh, we know Regelson. So well, one thing led to another. And on a cold and rainy night, I took a bus into Buffalo, New York. And I met Bill Regelson in the laboratory at Roswell Park Memorial Institute. It was late at night, and it was freezing rain, kind of miserable night. And he asked me a lot of very tough questions and was not very pleasant toward me. But the end of the interview, he says, I like the way you think. And I'd like to offer you an opportunity to work with me this summer. And I jumped at that opportunity. And it was really, truly the turning point in my life in many ways. Because I, eventually, many years later ended up marrying Bill Regelson's daughter. My current wife-- DANIEL F. HAYES: I was not aware of that. LARRY NORTON: Yeah. Rachel, the love of my life, it was an extraordinary experience, because I got very close to family. And she was in New York at Columbia, at Barnard, the same time that I was in medical school. And so that's how it all came about. But anyway, Bill was really an inspirational character for many people of my generation who were in contact with him. Because he was just filled with enthusiasm, and energy, and optimism. You remember, the early days of oncology were very special. And by the way, if you want to catch a glimpse of that, it tends to be this book, The Death of Cancer. I'm giving it a big plug, fantastic book that captures the whole history of his life and cancer. But the early days is very important for people to recognize what it was like in those early days. It was just an enormous challenge just to get people to pay attention. The possibility that drugs could actually be useful in the treatment of cancer, and it was often ridiculed. I can tell you a little story later about my early experiences when I came to New York in that regard. DANIEL F. HAYES: So did you know you were going to be an oncologist when you went to med school? Or did that-- LARRY NORTON: I'll tell you two of the turning points in that regard that I think are particularly interesting. One is, at the very beginning of that summer, Bill Regelson brought me-- in those days, the labs were right next to the clinic, the inpatient service. And he brought me right from the lab a few steps in to see a patient who was admitted to the hospital with a pelvic tumor. I don't know what type, didn't register in my mind at that time, but a pelvic tumor that had grown very large. And it actually had eroded out into the skin and was large, and infected, and bleeding, and just awful. And the patient was in terrible pain. And he said, we're going to treat this patient with a new drug that I think is going to help her. And it's called methotrexate. And he treated with methotrexate, and I saw the I saw the medicine go into her arms. And over the next few weeks, during that summer, I saw this tumor shrink down. I saw the skin heal over. I saw the pain go away. And it was, I'm seeing this monster eating this woman from the inside out. And I'm seeing just this yellow chemical going in there, and the monster being defeated. It was like magic. It was something just beyond conception that, actually, you could take something that awful and that terrible, and actually give it medicine, and actually make it go away. And I said, this is a world I can't turn my back on. This is a world I have to be in. This is just a magical, wonderful world, where you can actually heal things that couldn't be healed by other ways, I mean, totally beyond surgery, totally beyond radiation. And here's medicine going in. So that hooked me. But at the very end of the summer, and toward the very end of my time there, another thing happened which would be a good segue. But also very important is the real person running medicine A at Roswell Park at that time was this person named Jim Holland. And Jim Holland was not there all summer, because he was riding a horse. And he had his daughter, one of his daughters on the horse. And the horse was acting very, very jittery. And he was a little afraid of what the horse would do. So he went close to a fence, where he could actually unload the daughter, so she can grab on to the fence. And the horse didn't bolt and crushed his hip against the fence. And so he was out with a fractured hip or pelvis the entire summer. But he was well enough toward the end of the summer to come in and speak to the summer students. And he came in, and he sat in a chair in the middle of the room. And all the summer students who gathered around him-- if I thought Bill Regelson had energy, to see this tornado of a personality in the room, with his loud booming voice and his probing questions, his clear intelligence and enthusiasm for his field and dedication to it was just inspirational. And so it was a crescendo of a summer for me. And that was it. The experience of Bill Regelson, the experience of Jim Holland, I knew that I was stuck. And even though other things were attracting my attention, nothing was going to capture my life as much as the medical oncology. DANIEL F. HAYES: You went on then to work with him for 10 years at Mount Sinai. LARRY NORTON: Right. DANIEL F. HAYES: In addition to what you've said, his obnoxious ties also always stood out for the rest of us. But those 10 years must have been unbelievable. Because the guy never quit thinking, at least in my experience with him. LARRY NORTON: I mean, there's so much to say about Jim Holland. I had the honor to speak his funeral, the sadness to speak at his funeral, but it was the honor to speak at his funeral related some of the stories. But there's so much to talk about him that it's actually worth a whole book, even an opera, with the bigger than life personality he was. But he captured something that I think was very important. And some of the early pioneers that we were talking about before really captured which is, I mean, these were real pioneers. I'll just give you a little side story. I mean, I came into grand rounds once, when I was working with him late, as I usually am to pretty much everything. But nevertheless, I came in a few minutes late, and everybody was gathered around. And I remember it was a thoracic specialist, a pulmonologist, who was actually conducting grand rounds. And as I walked in the door, he says, how come you're late, Larry? Were you out there saving lives? And everybody roared into uproarious laughter. Because medical oncology was the last step before the cemetery. Hopeless situations would all come to us. And then we'd give them drugs and not help people whatsoever. And of course, I felt this deep humiliation. I was a young doctor at the time, and all these great, senior people, great luminaries were arrayed around. But that was the attitude of a lot of people in medicine at that time is that hopeless situations, send it to them, they'll take care of it. They'll hold hands, whatever. And to see where we are today, and how many cases we cured, and how many patients we've cured, and how well we managed things, certainly, we don't cure enough. And you and I and our whole community is working hard on that. But we do cure a whole lot of people, and we do help their lives. And we do keep them functioning for a longer period of time with the medicines. So the people that went into the field at that time and actually established the field of oncology, medical oncology, at that time were really had to have a real pioneering spirit. And so Tom Frei obviously pops to mind in that regard, and many others. I could give a long list-- DANIEL F. HAYES: Well, I should say, I had the great privilege of training with Tom Frei and the pleasure of interviewing Dr. Freireich who, sadly, passed away a few weeks ago. I did not get to interview Dr. Holland. But because of his friendship with Dr. Frei, Dr. Holland adopted me as well, even though I was never working with him directly. And the three of those guys, I think our listeners need to understand, they were really cowboys. And they did things that we would now just, I think, repel, just have you can't do that sort of thing. But they did it, because they had to. As you said, there was nothing else to do. It took a special personality. LARRY NORTON: Totally-- I mean, everything you're saying is-- I agree with. But also, that's why we are where we are today is because they took chances, because they had a vision, and they attacked that vision very, very aggressively. And I'll do one more namedrop in music that is one of my and still friend is Quincy Jones. And Quincy Jones had this wonderful phrase in terms of jazz improvisation that was really very important to me. Sometimes, Larry, you have to jump without a parachute. And how do you get into an improvisation? You just start. And then it has a life of its own. And the better you get, the more experience you get, the better you start it, and the better you're going to develop it. But you just got to start. Hit the first note, doesn't matter what it is. And that kind of spirit of jumping in into it was really, very important. And I think that's something I really miss from modern oncology. If we're going to talk about where we are now compared to where we are then, a lot of things have changed that are very positive. Obviously, the amount of science that we have to draw from now is just astronomically greater than what we had in the early days, when we're talking about very primitive things. The whole Norton-Simon thing was all about attacking cell division, the best way of attacking cell division. We're so far beyond that in so many ways. That's one of the bigger changes. Our access to information, I mean, I had a question. I have to go to the library and got to cart catalogs, and pull books off the shelf, and open them up, and spend hours and spend days finding out one piece of information that now I can find out in about 15 seconds, if my fingers are slow on the keyboard, 15 seconds. And so that's it. But one of the major things is that it was all about concepts then. It was all about principles. The principle that antimitotics could actually make tumors shrink and could be beneficial. That's a principle. Combination chemotherapy is a principle. Dose dense sequential therapy, if you take it into further development of my area as a principle. And the overarching concepts on patient centrality of it also is that the early clinical trials were very small trials. Because each and every patient was a valuable piece of information. They were almost collections of anecdotes. And obviously, we've evolved way past that in very positive ways. But what you learned from the individual patient was extremely important to that generation of pioneers rather than large numbers. And I think we moved away from that. DANIEL F. HAYES: Actually, I'm going to interrupt you, because I think almost everybody I've interviewed has stories like you started out with. I saw a patient who I couldn't believe responded to X or Y. And I have the same stories. And I'm hoping our young folks still believe that's as important as filling out the meaningful use things on their documentation. I told my own son, I want him to be a doctor and not a documenter. You need to document, but you need to be a doctor. Can I segue into-- LARRY NORTON: We ought to spend the whole podcast on that topic someday. DANIEL F. HAYES: No, yeah, let's do that. LARRY NORTON: Because the thing is-- well, because I think that the thing is, when you're taking care of a patient, and you're thinking, obviously, we're always thinking what's best for the patient, all of us. But you're also thinking of gathering information in a verbal way about the patient. So you can talk about that patient to your colleagues, or write it as case reports, a series of case reports is a different mindset than when you're thinking about how am I going to fill out my electronic health record? And I think the mindset differences, and I frequently say to the younger people that I teach or that I'm in contact with, that they grew up in a digital world. And I grew up in an analog world. And the way you think in an analog world is very different than the way you think in a digital world. Maybe it's for the better. I mean, only history will tell, but I just miss that kind of analog thinking. Much of what we have today is because of it. DANIEL F. HAYES: Let me take you into your role in modeling and especially with the so-called Norton-Simon hypothesis. How did you hook up with Richard Simon? And what did he teach you? Because I find him to be a fascinating person. LARRY NORTON: Oh, a fascinating person, and obviously, one of the really important people in my professional career. The math was in there. Because along with, I mean, I studied math. I had studied math in college, and I was-- DANIEL F. HAYES: I should-- describe it. Just for a minute, describe what it is for our listeners. LARRY NORTON: Oh, the Norton-Simon hypothesis and the-- DANIEL F. HAYES: Yes. LARRY NORTON: All right. Oh, yeah, well-- DANIEL F. HAYES: Briefly, briefly. LARRY NORTON: It's very simple is that way before my time, Skipper Schabel and colleagues at Southern Research Institute had described the way experimental tumors in their laboratory grew which was exponential. And they made the observation called the Log Kill hypothesis, which is the Log Kill rule which is a given dose of given drug kills a percentage of the cells that are present rather than an absolute number of cells, which is actually counterintuitive. It shouldn't be that way if you think about it in terms of biochemistry, but it is that way. And we were all taught the Skipper Schabel model and Log Kill hypothesis. We were all taught that. And I was in the clinic taking care of a patient with Hodgkin's disease, nodular sclerosis Hodgkin's disease. And this patient had [INAUDIBLE] involvement with Hodgkin's disease. Remember, I was working with Vincent Davita, a great influence on my life, Bruce Chabner, Bob Young, many people who-- George Canellos, who you know very well, great luminaries doing lymphoma therapy as a clinical associate at the National Cancer Institute. Hampton's patient is they had to Hodgkin's disease, got MOPP chemotherapy, roared into complete remission. Basically, two cycles of MOPP, was in complete remission. I've been involved in oncology since the early days of MOPP to show you how long I've been involved in oncology. And I got four more cycles, because we give six cycles no matter what. We're two cycles beyond complete remission in that setting. And it was about a year. And the patient came back with mediastinal lymphadenopathy. The biopsy showed that was exactly the same lymphoma. Put him back on MOPP chemotherapy, and he responded again and went back into remission. I don't recall whether it was complete remission or partial remission. And I said, this is really fascinating, because the math was already in my head at the time. Because I thought I want to graph it out and show how well it fit the Log Kill hypothesis. And it didn't fit at all. I mean, it just didn't make any kind of sense. From a mathematical point of view, you couldn't make the equations fit. And about that same time, I became aware that others were describing that tumors were not really growing exponentially-- solid tumors were not growing exponentially as Skipper had shown in his laboratory models, a certain leukemia named leukemia 01210. But rather, by a very strange curve called a Gompertz curve, which was developed in 1825 by Benjamin Gompertz to fit actuarial data, actually, not anything in terms of biology. And that's an S shaped curve. So it looks exponential at the beginning. And then it bends over and eventually seems to try to reach a plateau size. And so I went back, and I applied the Skipper Schabel model mathematically to the Gompertz curve. And I realized that, for this individual patient, it would make a whole lot of sense if the tumor, when it was growing quickly, regressed more than when it was growing slowly at a very large size. In other words that the hypothesis is that the rate at which it would shrink is proportional to its rate of growth. And since, in a Gompertz curve, the rate of growth is always changing, the rate of shrinkage changes as a function of time as a tumor shrinking down. And that was of germ the idea. And then the question is how to test it. Under contract Arthur Bogden in Massachusetts did some animal modeling for us. And we published my first paper actually that showed tumors were growing in a Gompertzian fashion. And in fact, a subsequent paper showed that they regressed also in the Gompertzian fashion which is what the Norman-Simon hypothesis is. Almost immediately thereafter, a couple of implications, in terms of cancer therapeutics, and I want to get back to that. Remind me to get back to that later on. Because this is around 1977 or so that all this was really becoming clear. So it was actually one patient that made me think of it. I mean, frankly, it was one patient's experience that made me think of it. And that's what you were saying before, Dan, is the importance of learning from each individual patient. DANIEL F. HAYES: And actually, it's gone on to be tested in many, many trials. But probably the most definitive was run by Marc Citron and CLGB under your guidance. And I just want to say a few words, because Marc passed away just a few weeks ago. He was really instrumental in ASCO and very, very generous to the foundation. We'll miss him greatly. But that trial of 97-- LARRY NORTON: 41. DANIEL F. HAYES: 9741, demonstrated that dose density was superior to giving things in big doses for longer periods of time. Let me ask you about-- LARRY NORTON: I just want to second there what you're saying about Marc. I mean, just an incredible human being, an incredible person, incredible clinical scientist, and he was actually the first community clinician to chair a major national trial from a co-operative group which was just an intentional decision. I believe, you were involved in that decision, actually, Dan, Hyman Muss, certainly. DANIEL F. HAYES: Marc and I started in a group at the same time. And we grew very close. I miss him. Let me ask you to look into your crystal ball for a minute and that is with precision medicine and targeted therapy. Does the Norton-Simon hypothesis still apply to that? Do you think chemotherapy still-- LARRY NORTON: Oh, yes. Oh, yeah, yeah. Well, first of all, I mean, I'm not-- now we're getting into sophisticated science topics here. But the thing is that I'm not, to this day, I'm not sure I have chemotherapy works. I don't think that all of chemotherapy effect is just killing dividing cells. First of all, it's mathematically impossible. Does chemotherapy, does cytotoxic therapy affect the relation cell to its microenvironment? Does it affect its relationship to the immune system? These are all things that are under active investigation and active study at the present time. There's more to what we do every day in terms of giving chemotherapy than just killing dividing cells. Chemotherapy can be very precise. I mean, methotrexate and dihydrofolate reductase, we talked about it before. It's very, very precise therapy, hormone therapy, tamoxifen and the estrogen receptor. So we've been talking about precision medicine for a long time. It's just that our level of sophistication in terms of likely targets has changed. But still, it works. It's a law that fast things, things that grow faster regress more quickly than things growing more slowly how you return them. And I think that there are important lessons there that we still have to learn about cancer biology. And that got me into some very exciting areas with [INAUDIBLE] and colleagues and to cell seeding theory with cancer, for example. And that story is evolving. And more data is becoming available there and much more sophisticated mathematics that will apply to those days that I hope I will have time to work on in the next few years to be able to actually establish those principles. But I still think that we're doing something wrong if you're talking about a crystal ball which is that-- and it relates to what I just said before. We're so self-hypnotized into thinking that cancer is a disease of cell division. The vast bulk of our targeted therapeutics are oriented toward molecules that are related to mitosis. You hear talk, that'll be a very specific talk about molecular pathways starting with genomics and [INAUDIBLE] signaling. At the end of the slide, it says, invasion, metastasis, and growth. It's a nice little package. And that's the answer. Well, I mean, that's a big cloudy area. I mean, those are different things. Those are separate things. Those all have their separate biology. But they're all related. It is totally true. And how are they related? And why are they related is one of the very important topics that we have to wrestle with, because that's what we really have to perturb. And I think that the, again, crystal ball guessing, or at least where I'm putting my energies now is we have all these incredible tools for developing medicinals that can attack molecules. Are we attacking the right molecules by focusing in cell division? Should we be looking more toward perturbing tumor microenvironment relationships? Should we look at more sophisticated ways of using the immune system as one element in the tumor microenvironment, one of many in the tumor microenvironment, to accomplish the goals that we have to accomplish? And are we actually looking at the right things in terms of molecular analysis in cancer by looking at pathways that are concerned with cell division primarily and secondarily with other things? Or should we be looking at molecular networks and molecular pathways in a more sophisticated fashion? Just like the early days of oncology, we have to be willing to take intellectual chances. And that's something I'm seeing much less of now than I did if you go back half a century. DANIEL F. HAYES: We can go on with this one for a long time too. And we probably will the next time we get to sit and have a drink together when the pandemic goes away. I think it relates to dormancy. And I don't think we understand dormancy or how it is broken and how to treat it. I have two things, and we're running out of time. One of those is you probably, in my opinion, have been the king of understanding the importance of philanthropy in our field, especially in relationship to what I see directly, which was your relationship with Evelyn Lauder and her husband, Leonard, of course, in the Breast Cancer Research Foundation. But I'd just like you to emphasize to the folks coming in the field how important that philanthropy is. I think some of them believe it's dirty to get involved with that and ask people to give money. And you and other people I think have taught a lot of us that these folks want to help us. And it's important to address that in a dignified way. LARRY NORTON: We're all in this together. I mean, I think that's the important thing to recognize as a physician or as a scientist. I said in a paper once that just as all of us are either actual or potential healers, all of us are actual or potential patients. Cancer is a very important problem that needs to be solved. And people have to solve in every way they can, with our intellectual ability, our hard work in the clinic, our hard work in the laboratory. And people who are working hard in other fields who accumulate some element of wealth, or even people that just in normal life contribute small amounts, a lot of people doing small amounts adds up to a lot of money also. I mean, they're all part of the same process. I mean, the importance of philanthropy is that-- and it goes back to what Evelyn said which I quote all the time. She was very instrumental in the building of our first breast center at Memorial Sloan Kettering and then our second breast center, which is freestanding building at Memorial Sloan Kettering. She and Leonard involved in every way and not just in terms of philanthropy, but actually thinking through the problems and helping solve them and design in every way. When we built the first building that we had, we actually raised a little bit more money than we needed for the actual physical structure. So the question is, what to do with it? And obviously, a research fund at Memorial was established. But then in terms of where else to go with it, she invited me over to her place in New York overlooking Central Park. And we sat in the kitchen, and we drank tea. And I said, what I perceive, and with my colleagues, I'm not the only one, obviously, who's perceiving this, is an explosion of science, basic science in understanding cancer, and an incredible collection of clinical investigators that can do clinical trials, and do large clinical trials as well as pilot clinical trials in our institutions. But I didn't see the connections being very tight. Because we were in different worlds, speaking somewhat different languages. And we had to tighten those connections somehow and do something translating scientific advances in the laboratory into clinical benefit. It also allowed the scientists to understand what the clinical problems were and how to have the approach, and how we're going to do this. And she said, I've worked around creative people all my life in my professional life. And I know, you've got to identify the right people first of all. So that's a little bit of a talent. But that the main thing is that when you identify them, you've got to give them freedom to use their imagination and the security to know that if they do something good and it doesn't work out, that they're not going to lose their job. Freedom and security is the secret of making progress in the field. And I said, that's what we need. We need a foundation that can give the right people the freedom to use their imagination and the security to know that as long as they do good work, they're not going to lose their funding in a more traditional grant mechanism. And that's really where it started. So the whole thing is all based on that, is to get the right people and to give them freedom and security. And another part of it I just want to mention is networking to give people-- DANIEL F. HAYES: So let me focus this. LARRY NORTON: OK. DANIEL F. HAYES: Breast Cancer Research Foundation, how many people are you supporting? And how much money did you give this year? Just to give-- LARRY NORTON: Oh, about, oh, I mean, it's about 200 or so or more than that. Investigators, it's international at the present time. This year has been a tough year, and the next few years probably, because of COVID, because of the pandemic. It's been a tough year. But in general, we've probably given away about a billion dollars. But it's not given away. It's actually an investment, investment in the future. DANIEL F. HAYES: Yes. I agree. LARRY NORTON: And it's all about bringing people together. New investigators come in, and they're used to gladiatorial combat when it comes to grant acquisition is that they have to fight against the people to beat them out. And what we reward is people working together and sharing ideas. And phenomenal things have occurred in that direction, phenomenal, huge programs in metastasis and molecular biology, Translational Breast Cancer Research Consortium which has been a fantastic thing that we've helped support. So it's really been a joy. DANIEL F. HAYES: It's been great. Final 1 minute, the other thing you've done as well or better than most is mentoring. And I personally want to thank you for helping me in my career. But probably, your greatest success is mentoring Cliff Hudis who's now the CEO of ASCO and is responsible for ASCO continuing to be probably the world's greatest oncology professional society. Actually not probably, in my opinion, for sure. So for that, I thank you. We've run out of time, unfortunately. I think you and I could go on for another hour or so with this stuff which is what's fun about my getting to do this. But I want to thank you for all you've done for the field, for all you've done for so many of us in the field, and most importantly, for the patients who have benefited from what you've done. It's pretty remarkable. This has been so much fun for me to get to interview so many of the pioneers. But you certainly rank up there at the top. So thank you very much for your time and look forward to talking to you later. LARRY NORTON: Thank you so much for the kind words and for inviting me to do this with you, Dan. Thank you. [MUSIC PLAYING] DANIEL F. HAYES: Until next time, thank you for listening to this JCO's Cancer Stories, the Art of Oncology podcast. If you enjoyed what you heard today, don't forget to give us a rating or review on Apple Podcasts or wherever you listen. While you're there, be sure to subscribe so you never miss an episode. JCO's Cancer Stories, the Art of Oncology podcast is just one of ASCO's many podcasts. You can find all the shows at podcast.asco.org. [MUSIC PLAYING]

covid-19 ceo music new york university death art conversations freedom thinking cancer train massachusetts vietnam buffalo math columbia scientists holland bronx long island memorial physicians bob dylan elton john rochester vietnam war dose remind american association investigators central park new york post norton hopeless frei hampton andy warhol pioneers quincy jones mount sinai oncology combination mcguire elton skipper barnard chemotherapy mcnamara cancer research greenwich village hodgkin catskills asco national cancer institute clinical oncology eastman school memorial sloan kettering inaudible daniel f columbia university college dan hayes bob young jco breast cancer research foundation music playing cold spring harbor cold spring harbor laboratory cancer stories roswell park rochester university mopp richard simon karnofsky transcript speaker ron bloom sermonix pharmaceuticals norton simon asco podcast network

Say La Vie - A Boutique Where Everyone Knows Your Name. Owned by Jane Zuckerberg.

I'm Ma'am As Hell

Play Episode Listen Later Mar 20, 2021 55:25

There is an adorable boutique in Cold Spring Harbor that is a social mecca for Ma'ams on Long Island. Jane Zuckerberg is the owner of Say la Vie a place where everyone knows your name and life lessons are shared with raw honesty.

mark zuckerberg long island la vie owned boutique vie everyone knows cold spring harbor

EP 028 - Year In Review: 1971

new york paypal billy joel cold spring harbor

Play Episode Listen Later Mar 2, 2021 50:34

Apart from the botched release of Cold Spring Harbor, 1971 was a surprisingly low-key year for Billy Joel. His teenage band collapsed a few years before. And the proto-metal power duo that rose from its ashes failed to gain any traction. Broke, depressed, and aimless, Billy was ready to leave the music industry for good. And, he may have done just that, if his manager at the time didn’t come through with a last-minute deal. Of course, that deal would haunt Billy for years to come. After the album was released in November, he played a sparse handful of dates in New York at the end of the year. Meanwhile, there are no reviews, interviews, or press clippings to speak of. But look closely, and you’ll see a lot of small things develop, arrive, or otherwise get set in motion and affect his trajectory for decades to come. Join us as we dive deep into 1971. ------ Email us: glasshousespodcast@gmail.com Glass Houses - A Billy Joel Podcast on the web / social media: Website: http://www.glasshousespod.com Facebook: https://www.facebook.com/glasshousespodcast/ Instagram: https://www.instagram.com/glasshousespod/ Twitter: https://twitter.com/glasshousespod Support the podcast: Paypal: https://paypal.me/glasshousespod Venmo: @MGrosvenor

EP 5: Wally's World ft. Wally Szczerbiak (NBA All Star, College Basketball Analyst at CBS & New York Knicks Analyst at MSG)

Level Up Your Basketball Podcast

Play Episode Listen Later Dec 3, 2020 54:35

This is the Level Up Your Basketball Podcast hosted by Evan Conti & Jesse Winter. In this fifth episode, they have Wally Szczerbiak (NBA All Star, College Basketball Analyst at CBS & New York Knicks Analyst at MSG) & go in depth on to discuss: Basketball coming back, Growing up abroad & his Dad being a pro player, his family settling in Cold Spring Harbor, having 5 kids and coaching them, going to Cold Spring Harbor High School, playing other sports & why he didn't play elsewhere, not thinking he was going to be recruited & choosing Miami of Ohio before his Senior Year, the coaching staff & wanting to be developed, the importance of getting stronger & taking the keys as a Junior, getting into the NCAA Tournament, Level Up Your Game Moment of the Week, NBA Draft Process & working out for The Top 7 Teams, being the drafted was the starting line, winning 50 Games every season in Minnesota, relationship with Kevin Garnett & making an All Star Team, Latrell Sprewell, Sam Cassell & pushing the Shaq/Kobe Lakers to 6 Games, being traded to Boston, Seattle & Cleveland, playing with Paul Pierce, Kevin Durant & LeBron James, how the game has evolved today, covering the Knicks & their team this season & so much more! This episode is not to be missed! Sponsored by: Sharestates Sharestates has funded over $2.5 billion in real estate deals, and if you're a real estate developer in need of funding, Sharestates can partner with you on your next project. They fund every property type: residential, multifamily, mixed-use, commercial and land across different stages of development from ground-up construction, fix-and-flip projects, heavy rehab, refinancing, and more. To learn more, visit invest.sharestates.com/levelup Rockwell Developers, building your luxury dream house in Long Island. Don’t believe me, just check out their instagram @RockwellDevelopers or visit RockwellDevelopers.com. Home Instead Senior Care The most trusted non-medical provider of companionship, meal preparation, light housekeeping, medication reminders, errands, shopping, transportation, personal & hygiene care, and Alzheimer’s and Dementia Care. Learn more at www.homeinstead.com or call them at 516-826-6307 Follow: Instagram @epconti21 @winterfresh12 @levelupyourbballpod @levelup_li @dbpodcasts @wallyball10 Twitter @levelupbballpod @levelup_li @dbpodcasts @wallyball10 Contact www.LevelUpLI.com Produced by DBPodcasts.com

My Music Seen Ep2: Billy Joel

My Music Seen

Play Episode Listen Later Nov 24, 2020 24:56

Our feature artist for Episode 2 is dedicated to the timeless and soul stirring story telling of Billy Joel. We go way back to the early years featuring songs from Cold Spring Harbor, Piano Man, and Turnstiles. Billy deals deeply with loss, numbing the pain of life, and dealing with Manic Depression. The Jeff's and I explore 3 songs that are sure to send you to that special island. Theme Song written by Fran Capitanelli and performed by The Tom Collins. https://open.spotify.com/track/5kIth7qtWNGSSsxUdGojQk?si=Yf7Ea_5bRji8itrgIlhCwg All songs mentioned in this episode can be found at https://www.youtube.com/playlist?list=PL0p7t2ZLBY7DAjXHfBdKc-1NEtSOF4ARC Follow on IG @MyMusicSeen

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38. UCSD professor, Ashley Juavinett, on teaching, coding, and why neuroscience is the best science

Once a Scientist

Play Episode Listen Later Nov 11, 2020 78:49

Episode 38. Ashley Juavinett is an Assistant Teaching Professor at UC San Diego. She did her undergraduate degree at Lafayette College, PhD at UC San Diego, and postdoc at Cold Spring Harbor.

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CRISPY COATED ROBOTS Listen To... Billy Joel's "THE STRANGER"

Crispy Coated Robots

Play Episode Listen Later Aug 17, 2020 25:00

CRISPY COATED ROBOTS LISTEN TO...Jim & George listen and discuss Billy Joel's 1977 landmark album THE STRANGER.[Original Air Date: 08/16/20 on Houston Radio Platinum]Don't have the recording?Listen to it on YouTube for free here:https://www.youtube.com/watch?v=cJtL8vWNZ4o&list=PLraUXdMOSKKFGJHUKaZnsswkOMFrwHsE5A sample of the amazingly horrible (sped up) production of Billy Joel's COLD SPRING HARBOR: https://www.youtube.com/watch?v=gi3snA_uuKs

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Dr. Anne Churchland

Stories of WiN

Play Episode Listen Later Jul 22, 2020 32:52

This episode features Megan’s interview with Anne, who studies the neural circuits and computations underlying decision-making at Cold Spring Harbor (and will soon be moving her lab to the University of California - Los Angeles).

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Episode 9: The inspiring story of Barbara McClintock

Computationally Yours

Play Episode Listen Later Jul 7, 2020 14:53

In our first "Profiles in Scientific Genius" series, we discuss the inspiring story of Dr. Barbara McClintock (1902-1992), the first woman to have received a solo Nobel Prize in Physiology or Medicine. Achieving success against all odds, her story will make you believe. Dr. Sabah Kadri and Arshi Arora peek into her childhood, her support system, the odds she faced when she wanted to research in genetics at a time that women were not accepted into that department, and her eventual triumph in the field. Link to National Academy of Science: http://www.nasonline.org/publications/biographical-memoirs/memoir-pdfs/mcclintock-barbara.pdf Research Review: https://www.pnas.org/content/109/50/20198 Contact us with questions, feedback and requests to collaborate on future episodes at computationallyyours@gmail.com. Follow us on Twitter: @compbiopodcast ; Dr. Sabah Kadri: @sabahkadri ; Arshi Arora: @arorarshi Intro/Outro music: Riatsu (Shadaab Kadri) Follow us on YouTube here. Follow us on Instagram here. Photo from Cold Spring Harbor. --- Send in a voice message: https://anchor.fm/computationally-yours/message

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#430 - Jason Burge - It's Still Billy Joel to Me - Vol. 1

The Paul Leslie Hour

Play Episode Listen Later Jul 6, 2020 31:42

430 - Jason Burge - It's Still Billy Joel to Me - Vol. 1 This is a special edition of The Paul Leslie Hour. It's going to be coming out every month and it's a somewhat in-depth discussion about the singer-songwriter, pianist and recording artist Billy Joel. I believe Billy Joel to be one of the most important American recording artists. He's sold more than 150 million records since his debut in 1971. I'll be joined in each episode of this series with a music reviewer Jason Burge, who has reviewed more than 100 albums. Burge is a writer, classically-trained pianist, and commentator. He is also a connoisseur of Billy Joel's music. On each episode we'll discuss in chronological order, all of Billy Joel's studio records. It starts with Cold Spring Harbor in 1971 and the last studio album was the classical album Fantasies and Delusions that came out in 2001. So it will be a 13-part look at all of the albums. Volume 1 explores Billy Joel's debut album: "Cold Spring Harbor," produced by Artie Ripp. It was recorded in July 1971 and released November 1, 1971. You are invited to listen to the discussion right here on The Paul Leslie Hour. The Paul Leslie Hour is a talk show dedicated to “Helping People Tell Their Stories.” Some of the most iconic people of all time drop in to chat. Frequent topics include Arts, Entertainment and Culture.

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The Whaling Museum

Plugged In To Long Island

Play Episode Listen Later Jun 25, 2020 21:39

Al Levine talks with Brenna McCormick-Thompson, Curator of Education at The Whaling Museum in Cold Spring Harbor. To find out more info on their virtual programs, in-person camp sessions in August, and the upcoming Shinnecock Artists & Long Island's First Whalers exhibit this fall, head to cshwhalingmuseum.org

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S14E1. God Mansplained to Me

Think Outside the Box Set

Play Episode Listen Later Jun 8, 2020 64:48

Cold Spring Harbor by Billy Joel Click here to join our Discord! (https://discord.gg/5vpqXaS) Learnin' Links: Listen along to Cold Spring Harbor here! (https://open.spotify.com/album/274rMlKrr22086ohmwAJZA?si=PRMeIKKWRX2W93qSRj8CWg) You can support us in several ways: Kick us a few bux on Patreon! (https://www.patreon.com/boxset) By becoming a supporting member, you'll gain access to special bonus episodes, including a weekly mini-show, What's in the Box Weekly! Buy T-shirts, sweatshirts, and more at our merch page! (https://boxset.threadless.com/)

music discord kick billy joel cold spring harbor cultural criticism

Episode 112: Long Island Whaling and Brenna McCormick-Thompson

The Long Island History Project

Play Episode Listen Later May 6, 2020 34:41

We return today to the sea to consider the whale. More specifically, we talk with Brenna McCormick-Thompson of the Whaling Museum and Education Center in Cold Spring Harbor. Brenna is the Curator of Education at the museum and helps tell the story of Long Island whaling to visitors of all ages. Our discussion covers the important role Long Island played in the development of the whaling industry in America, the important role that museums play in educating us about the past, and the appeal of historic bathrooms. Further Research The Whaling Museum & Education Center @CSHWhaling on Twitter How to Dissect a Whale Sag Harbor Whaling Tales Whaling (On This Site) Royal Museums Greenwich Audio Footnotes Episode 88 with Erin Elizabeth Becker Episode 82 with John Strong

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EP 003 - Album Retrospective: Cold Spring Harbor

columbia retrospective cold spring harbor michael jack

Play Episode Listen Later Mar 17, 2020 60:26

Michael & Jack revisit Billy's first album, from its pre-production demos, to the botched finished product under Artie Ripp's Family Productions, Columbia’s 1983 remix and reissue, and everything in between.

The Fastest-Growing Plant In The World

MinuteEarth

Play Episode Listen Later Jan 31, 2020 2:50

Get your first audiobook and two Audible Originals for free when you try Audible for 30 days visit https://www.audible.com/minuteearth or text “minuteearth” to 500-500! Bamboo is the world’s fastest growing plant thanks to the cell elongation process it shares with all grasses and its unique cell wall layering adaptation, allowing it to shoot up to 100 ft (30m) in just 8 weeks. Thanks also to our Patreon patrons https://www.patreon.com/MinuteEarth and our YouTube members. ___________________________________________ To learn more, start your googling with these keywords: Rhizome: a continuously growing horizontal underground stem which puts out lateral shoots and roots at intervals Vacuole: an organelle within the cytoplasm of a cell, enclosed by a membrane and typically containing fluid, whose main purpose in plants is to maintain pressure against the cell wall Microfibrils: fiber-like strands consisting of glycoproteins and cellulose that make up the cell wall structure Auxin: a plant hormone which causes the elongation of cells in shoots and is involved in regulating plant growth ___________________________________________ If you liked this week’s video, you might also like: Fastest growing plant record - https://www.guinnessworldrecords.com/world-records/fastest-growing-plant Grass: An Introduction - https://lizzieharper.co.uk/2018/06/grass-an-introduction/ Bamboo Shoot Timelapse - https://www.youtube.com/watch?v=77Pgqf0rTbY _________________________________________ Subscribe to MinuteEarth on YouTube: http://goo.gl/EpIDGd Support us on Patreon: https://goo.gl/ZVgLQZ And visit our website: https://www.minuteearth.com/ Say hello on Facebook: http://goo.gl/FpAvo6 And Twitter: http://goo.gl/Y1aWVC And download our videos on itunes: https://goo.gl/sfwS6n ___________________________________________ Credits (and Twitter handles): Video Narrator, Script Writer, and Co-Director: Julián Gustavo Gómez (@ittakesii) Script Editor: David Goldenberg (@dgoldenberg) Video Illustrator and Co-Director: Ever Salazar (@eversalazar) With Contributions From: Henry Reich, Alex Reich, Kate Yoshida, Peter Reich, Sarah Berman, Arcadi Garcia Rius Music by: Nathaniel Schroeder: http://www.soundcloud.com/drschroeder ___________________________________________ References: Velasquez, Silvia Melina, et al. "Auxin and cellular elongation." Plant Physiology 170.3 (2016): 1206-1215. Nonami, Hiroshi. "Plant water relations and control of cell elongation at low water potentials." Journal of Plant Research 111.3 (1998): 373-382. Wei, Qiang, et al. "Cellular and molecular characterizations of a slow-growth variant provide insights into the fast growth of bamboo." Tree physiology 38.4 (2018): 641-654. Li, Long, et al. "The association of hormone signalling genes, transcription and changes in shoot anatomy during moso bamboo growth." Plant biotechnology journal 16.1 (2018): 72-85. Gritsch, Cristina Sanchis, Gunnar Kleist, and Richard J. Murphy. "Developmental changes in cell wall structure of phloem fibres of the bamboo Dendrocalamus asper." Annals of Botany 94.4 (2004): 497-505. Gamuyao, Rico, et al. "Hormone distribution and transcriptome profiles in bamboo shoots provide insights on bamboo stem emergence and growth." Plant and Cell Physiology 58.4 (2017): 702-716. Wysocki, William P., et al. "Evolution of the bamboos (Bambusoideae; Poaceae): a full plastome phylogenomic analysis." BMC evolutionary biology 15.1 (2015): 50. Cosgrove, Daniel J. "Catalysts of plant cell wall loosening." F1000Research 5 (2016). Lodish, Harvey, et al. "Molecular cell biology 4th edition." National Center for Biotechnology Information, Bookshelf (2000). Perrot-Rechenmann, Catherine. "Cellular responses to auxin: division versus expansion." Cold Spring Harbor perspectives in biology 2.5 (2010): a001446. Gritsch, Cristina Sanchis, and Richard J. Murphy. "Ultrastructure of fibre and parenchyma cell walls during early stages of culm development in Dendrocalamus asper." Annals of botany 95.4 (2005): 619-629. Lybeer, Bieke, et al. "Lignification and cell wall thickening in nodes of Phyllostachys viridiglaucescens and Phyllostachys nigra." Annals of botany 97.4 (2006): 529-539. Tsuyama, Taku, et al. "Lignification in developing culms of bamboo Sinobambusa tootsik." Journal of Wood Science 63.6 (2017): 551-559. Gibert, Anaïs, et al. "On the link between functional traits and growth rate: meta‐analysis shows effects change with plant size, as predicted." Journal of Ecology 104.5 (2016): 1488-1503.

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Episode 2: Eating for Two - The Impact of diet on Gut Microbial Diversity

The Gut Brain Access

Play Episode Listen Later Dec 3, 2019 24:49

References 1. Poffenroth, M. [Mahalo Dot Com]. (2011, January 21) Learn Biology: Classification- The Taxonomic Hierarchy [video file]. Retrieved from: https://www.youtube.com/watch?v=kKwOlAqQoLk 2. Tomova, A., Bukovsky, I., Rembert, E., Yonas, W., Alwarith, J., Barnard, N. D., & Kahleova, H. (2019). The Effects of Vegetarian and Vegan Diets on Gut Microbiota. Frontiers in nutrition, 6, 47-47. doi:10.3389/fnut.2019.00047 3. Dinu, M., Abbate, R., Gensini, G. F., Casini, A., & Sofi, F. (2017). Vegetarian, vegan diets and multiple health outcomes: A systematic review with meta-analysis of observational studies. Critical Reviews in Food Science and Nutrition, 57(17), 3640-3649. doi:10.1080/10408398.2016.1138447 4. Petre, A. (2016, August 5). Vegan vs Vegetarian - What's The Difference? Retrieved from https://www.healthline.com/nutrition/vegan-vs-vegetarian. 5. Daneman, R., & Prat, A. (2015). The blood-brain barrier. Cold Spring Harbor perspectives in biology, 7(1), a020412. doi:10.1101/cshperspect.a020412 6. Del Rio, D., Zimetti, F., Caffarra, P., Tassotti, M., Bernini, F., Brighenti, F., … Zanotti, I. (2017). The Gut Microbial Metabolite Trimethylamine-N-Oxide Is Present in Human Cerebrospinal Fluid. Nutrients, 9(10), 1053. doi:10.3390/nu9101053 7. Mawer, R. (2018, July 30). The Ketogenic Diet: A Detailed Beginner's Guide to Keto https://www.healthline.com/nutrition/ketogenic-diet-101#foods-to-avoid 8. Lindefeldt, M., Eng, A., Darban, H. et al. The ketogenic diet influences taxonomic and functional composition of the gut microbiota in children with severe epilepsy. npj Biofilms Microbiomes 5, 5 (2019) doi:10.1038/s41522-018-0073-2 9. Ercolini, D., & Fogliano, V. (2018). Food Design To Feed the Human Gut Microbiota. Journal of agricultural and food chemistry, 66(15), 3754–3758. doi:10.1021/acs.jafc.8b00456 10. Lonnie, M., Hooker, E., Brunstrom, J. M., Corfe, B. M., Green, M. A., Watson, A. W., … Johnstone, A. M. (2018). Protein for Life: Review of Optimal Protein Intake, Sustainable Dietary Sources and the Effect on Appetite in Ageing Adults. Nutrients, 10(3), 360. doi:10.3390/nu10030360 11. Lăcătușu, C. M., Grigorescu, E. D., Floria, M., Onofriescu, A., & Mihai, B. M. (2019). The Mediterranean Diet: From an Environment-Driven Food Culture to an Emerging Medical Prescription. International journal of environmental research and public health, 16(6), 942. doi:10.3390/ijerph16060942 Music Credits: "Feelin Good" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/by/4.0/

Billy Joel

Rock Solid

Play Episode Listen Later Nov 28, 2019 175:38

Pat welcomes fellow podcaster Jon Lamoreaux (The Hustle Podcast) back to the guest Co-Host chair for an in depth look at Billy Joel's complete recording career.

comedy songs bridge stranger billy joel comedy podcasts glass houses piano man innocent man stormfront hustle podcast turnstiles phil ramone cold spring harbor pat francis jon lamoreaux rock solid podcast

Whaling Museum

Plugged In To Long Island

Play Episode Listen Later Aug 15, 2019 21:54

Ted Lindner talks with Nomi Dayan, the Executive Director of the Whaling Museum in Cold Spring Harbor

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Episode 9: "Have a Nice DNA" Children's Book Review

Molecular Mom

Play Episode Listen Later Jul 10, 2019 5:38

"Have a Nice DNA" is a children's educational book that is one of the four books from the "Enjoy Your Cells Series" published by Cold Spring Harbor.

children's books cold spring harbor

TWiV 551: Golden hands

This Week in Virology

Play Episode Listen Later Jun 9, 2019 60:07

At Retroviruses 2019 in Cold Spring Harbor, Vincent speaks with virologist Bryan Cullen about his work and his career, together with former associates Ann Skalka, Paul Bieniasz, and Michael Malim. Host: Vincent Racaniello Guests: Bryan Cullen, Paul Bieniasz, Michael Malim, and Ann Skalka Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

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TWiV 551: Golden hands

This Week in Virology

Play Episode Listen Later Jun 9, 2019 60:07

At Retroviruses 2019 in Cold Spring Harbor, Vincent speaks with virologist Bryan Cullen about his work and his career, together with former associates Ann Skalka, Paul Bieniasz, and Michael Malim. Host: Vincent Racaniello Guests: Bryan Cullen, Paul Bieniasz, Michael Malim, and Ann Skalka Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

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Hidden Past: Cold Spring Harbor's forgotten graveyard

News 12 Talks Long Island

Play Episode Listen Later Mar 15, 2019 5:40

Danielle Campbell checks out a forgotten graveyard from the 1800s recently uncovered near St. John’s Episcopal Church in Cold Spring Harbor.

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CEEP Voices: The Rev. Gideon Pollach on Care in the Opioid Era - CEEP Podcast Team

CEEP 2019 Conference Podcast

Play Episode Listen Later Feb 22, 2019 5:24

The Rev. Gideon Pollach discusses how his parish, St. John's in Cold Spring Harbor, works to combat the opioid epidemic through humanity and care for victims and their families -- and also through strategic community partnerships, training, thoughtful planning and hard work.

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CEEP Voices: The Rev. Gideon Pollach on Care in the Opioid Era - CEEP Podcast Team

CEEP 2019 Conference Podcast

Play Episode Listen Later Feb 22, 2019 5:24

The Rev. Gideon Pollach discusses how his parish, St. John's in Cold Spring Harbor, works to combat the opioid epidemic through humanity and care for victims and their families -- and also through strategic community partnerships, training, thoughtful planning and hard work.

care rev voices opioids podcast teams cold spring harbor

Evolving Soul with Pat Longo: Pat Longo Interviews Medium Diana Cinquemani

Evolving Soul Network

Play Episode Listen Later Sep 13, 2018 77:00

In 2005, a friend introduced Diana to Pat Longo’s spirituality classes. From this point on, Diana embarked upon an unexpected spiritual journey; over the next seven years, she continued to take these classes and her abilities truly began to develop. She has learned the importance of gratitude, forgiveness, self-love, and balance, as they are the keys to realizing one’s true potential and healing all anxieties. Through her learning in class and life, Diana came to understand that she was an empath. In other words, she would pick up on the different energies that surrounded her. After her second past life regression with Pat, many of Diana’s unexplained fears miraculously vanished and she was able to connect with Spirit on a deeper level. Diana understood that a new path was unfolding in front of her, and though apprehensive, she felt guided to follow it, as she had faith that the Universe was revealing her Divine purpose. She has embraced her mediumship abilities and uses them to help heal and guide others by giving them loving messages from the beyond. She is capable of channeling the Divine life paths of her clients and helping them to make decisions that will allow them to find happiness and peace. Presently, Diana is a successful Spiritual Medium living and working in Cold Spring Harbor, New York. Her contact Information is as follows: Email: readingsbydiana55@gmail.com Phone: 631-659-3535 Text Only: 631-897-3278

new york spirit soul universe spirituality divine medium healers evolving messages psychic medium spiritual medium cold spring harbor pat longo

TWiV 510: Retroviruses at Cold Spring Harbor

This Week in Virology

Play Episode Listen Later Sep 9, 2018 64:13

Vincent and Dickson travel to the 44th Retrovirus meeting at Cold Spring Harbor Laboratories, where they speak with John Coffin, Stephen Hughes, Ya-Chi Ho, and Matt Takata about the meeting and their work on HIV-1. Hosts: Vincent Racaniello and Dickson Despommier Guests: John Coffin, Stephen Hughes, Ya-Chi Ho, and Matt Takata Become a patron of TWiV! Links for this episode Cold Spring Harbor Retrovirus Meeting 2018 Retroviruses and cranberries (TWiV 320) Identical proviruses in HIV-1 reservoir (PLoS Path) Measuring HIV-1 latency (PNAS) CG dinucleotide suppression is host defense (Nature) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

225 Don Saladino: Stop Resisting Your Resistance Training

Wellness Force Radio

Play Episode Listen Later Aug 17, 2018 61:02

Feeling insecure is normal when someone's not used to being in the fitness environment. Even though you feel intimated by the gym, the truth is that no cares about how you look or about what type of shape you're in. If you're at the gym and you're a good, quality human being who's putting an effort in, I have great respect for you. - Don Saladino Do you believe that the only way to lose weight, get healthy, and stay fit for life is to have a no pain, no gain mentality? JOIN THE FACEBOOK GROUP | REVIEW THIS PODCAST 20% OFF ORGANIFI - USE CODE: WELLNESSFORCE On Wellness Force Radio episode 225, world-class and world-renowned health & fitness professional, owner of Drive495 Health Clubs, and Creator of the Playbook App, Don Saladino, explains why you don't have to beat yourself up to get in shape, how to build healthy, realistic habits for life, and what you should be looking for in a personal trainer. Learn how to get over your fear of the gym by having a specific workout plan that matches your focus, needs, and wants. "Resistance training should be your fitness foundation. Do cardio for recovery, to break a sweat, or to burn a little bit more fat but it shouldn't be your entire focus." - @DonSaladino on @WellnessForce Radio episode 225 http://bit.ly/wfpodcast Download The Playbook App Click here to download the Playbook App now What is Playbook? Easily monetize your health, fitness and wellness content and create a meaningful recurring revenue. What does Playbook include? Membership $9.99/month Suit Up & Tone Up Programs (Programs Section) 6 Week Contests, HUGE PRIZES! New weekly bonus workouts (Workout Section) Feature celebrity workouts (Workout Section) Nutrition Plan (Insights Section) Customer support All available through the Playbook iOS App! SuitUp & ToneUp Programs Playbook's SuitUp & ToneUp programs are available through the Playbook App NEW 6-WEEK PROGRAMS EVERY 2 MONTHS! SuitUp 6 Week / 5 Days per Week Program My Suit Up Program is designed to pack on muscle, shed body fat and build athleticism, all while retaining mobility and flexibility. Suit Up represents the culmination of 20 years experience in the fitness industry. These programs use the same training principles I’ve used with the likes of Ryan Reynolds, Liev Schreiber, Sebastian Stan and others. This 6-week program will progressively get more difficult from week to week. Starting week 4, the program will introduce new movements and bonus rounds. This approach will allow you to perfect the skills you are working on and provides the greatest adaptation potential for your body. ToneUp 6 Week / 5 Days per Week Program My Tone Up Program is designed to torch body fat, create lean toned muscles and build athleticism, all while retaining mobility and flexibility. Tone Up represents the culmination of 20 years experience in the fitness industry. These programs use the same training principles I’ve used with the likes of Blake Lively, Scarlett Johansson, Jennifer Aniston, Emily Blunt and others. This 6-week program will get progressively more difficult from week to week. Starting week 4, the program will introduce new exercises and bonus rounds. This approach will allow you to perfect the skills you are working on and provides the greatest adaptation potential for your body. Listen To Episode 225 As Don Saladino Uncovers: Why women are resisting from doing weight training when they don't have to be. Why he was so drawn in the world of strength training and bodybuilding. How his background and negative childhood experiences shaped who he is today. The contrast between fitness and wellness and how they're changing in the current industry. Why Planet Fitness wouldn't allow one of his clients to have a membership based on her weight. Why people are so hesitant to join a gym and start weight training. How he's helped people completely transform their lives by creating healthy habits rather than looking for that quick fix. The wrong advice that people are giving to their clients or on social media. Why it's better to work one-on-one with a personal coach rather than a social media influencer. The biggest No-Nos to be aware of and avoid in a personal trainer. Why resistance training, not cardio, should be the foundation of your fitness plan for losing weight and living a healthy lifestyle. The importance of mixing up workouts for both a physical and mental beneficial standpoint. Why some of your favorite workouts might not be good for you but specific training can help you become the strongest version of yourself. How to integrate strength training into a holistic lifestyle based on self-love. The importance of having a mindset for longevity rather than just losing weight. Train to failure: should you be doing it doing your workouts? Why he starts clients off with belly breathing and how much they focus on doing before working out. His own spiritual practice of thinking how he could be a better person. How his focus on physical intelligence has changed from when he was 20 to now at 40. Power Quotes From The Show "Getting fit isn't as hard as you think; you just took an incorrect approach because someone probably steered you in the wrong direction." - @DonSaladino on @WellnessForce Radio episode 225 http://bit.ly/wfpodcast "You don't have to be a gym killing yourself in the gym. You don't have to have this Biggest Loser approach to fitness or be vomiting after each workout. Being healthy is just about making better choices, moving in an intelligent way, and if people took that approach, they'd be able to reach their health and fitness goals a lot quicker and easier than they ever imagined. As I'm getting older, I'm finding that I may even need less and just do two-three movements each day. It's shocking how a little can go a long way." - Don Saladino "People find going to the gym very intimidating. When someone's not used to being in the fitness environment, they immediately feel insecure but the truth is, no one cares how you look. I don't care what type of shape you're in or what you look like. If you're at the gym and you're a good, quality human being who's putting an effort in, I have great respect for you. If you still feel insecure about the gym, just go in there for 10 minutes and do something really simple like a 3-movement circuit or run around the track to build confidence." - Don Saladino "Training a celebrity really isn't any different; they have families, work, and time constraints too. The only difference is that sometimes we have a definitive goal that has to be reached in 3 months. What people need is consistency. Some days you can go in there with just a 40-60% effort and it's all good because it's better than not doing anything for weeks. Plus that day off from the gym might be exactly what you need sometimes." - Don Saladino Links From Today's Show Don Saladino Facebook Twitter Instagram YouTube LinkedIn Drive495 Health Clubs Facebook Twitter Instagram Playbook App Don Saladino Blog Super Trainer: Meet The Man Behind Some of Hollywood's Fittest Action Heroes Don's No-Hangover Playbook Don Saladino On Training Celebrities, Running A Gym, And Getting Cover-Ready In 30 Days Don Saladino'S 7-Week Plan To Get Shredded From Head To Toe Robert Irvine - Interview With Celebrity Trainer Don Saladino TrueForm Runner Treadmills Charlie Weingroff Kyle Balzer TMHS 280: Exercise Secrets & Building Superhero Bodies – With Celebrity Trainer Don Saladino WFR 203 Brian Mackenzie About Don Saladino Don Saladino is one of the most in-demand and respected trainers in the business. For over 20 years, he has coached actors, athletes, musicians, and titans of business function at their full potential. He is also responsible for some of Hollywood’s most coveted physiques. Ryan Reynolds, Blake Lively, Liev Schreiber, Sebastian Stan, Morgan Hoffman, Hugh Jackman, and David Harbour, are a few names off the roster of clients who have trained with him at Drive495 gym in Soho, Manhattan. Saladino has been tapped as a fitness expert in publications such as Men’s Health, Men’s Fitness, Met Rx and most recently, was featured on the cover of the March issue of Muscle and Fitness. He has also been featured in Origins, In Touch, US Weekly, and People; and has made appearances doing live fitness demos on The Today Show, Page Six TV, People NOW, The Better Show, & The Juice. Now Saladino is sharing his tried-and-true programming, along with cutting-edge techniques, with a worldwide audience through his social media accounts and the Playbook app, of which he serves as CTO. His ability to be at the forefront of fitness trends has garnered him the iconic Muscle & Fitness cover, as well as, made him a sought-after brand ambassador for top-tier health brands. Don lives in Cold Spring Harbor, NY with his wife, Mel, and their two children, Amelia and Donny Jr. Get More Wellness In Your Life Join the WFR Community on facebook Send Josh Trent a personal message Tweet me on Twitter: Send us a fun tweet (or a what's up) Comment on the Facebook page Sign up to get an email alert whenever we release a new episode Support This Podcast Leave a 5 star review on iTunes Share this episode with someone you care about Contact Wellness Force Radio for podcast sponsorship and partnership opportunities Rate & Review Wellness Force ---> REVIEW THE PODCAST Ask A Live Question For The Next Episode ---> Click here to leave a voicemail directly to Josh Trent to be read live on the air. You May Also Like These Episodes Food Freedom Forever With Melissa Hartwig Nir Eyal: Breaking Bad Habits, Technology Addiction, & Emotional Triggers Healthy, Happy & Harder To Kill w/ Steph Gaudreau of Stupid Easy Paleo Beyond Meditation: How To Get A Better Brain With Ariel Garten Living A Healthy Lifestyle In A Modern World With Dan Pardi Creating A Life Worth Living With Michael Strasner Join the Wellness Force Newsletter: www.wellnessforce.com/news Don't miss next week's show: Subscribe and stay updated Did you like this show on Ketosis? Rate and review Wellness Force on iTunes You read all the way to the bottom? That's what I call love! Write to me and let me know what you'd like to have to get more wellness in your life.

Episode #763: Phideaux’s – Infernal w. Clive Nolan, Christina Booth, Noel Calcaterra and Phideaux Xavier

Music In Widescreen - Prog Rock - All Inclusive

Play Episode Listen Later Jul 29, 2018 193:16

Time Artist Title Length Album Year Composer Label Listeners 18:02:12 Arena The Mirror Lies 6:53 Double Vision 2018 Verglas Music 52 18:09:05 miwshowopen 1:16 57 18:23:30 phideaux cast out and cold 5:15 infernal 2018 55 18:28:45 Billy Joel Falling of the Rain 2:31 Cold Spring Harbor 1971 Billy Joel Sbme Special MKTS. 53 18:31:16 Clive […]

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Episode #763: Phideaux’s – Infernal w. Clive Nolan, Christina Booth, Noel Calcaterra and Phideaux Xavier

Progrock.com's - Music in Widescreen's - Progressive Rock Podcast

Play Episode Listen Later Jul 29, 2018 193:16

Time Artist Title Length Album Year Composer Label Listeners 18:02:12 Arena The Mirror Lies 6:53 Double Vision 2018 Verglas Music 52 18:09:05 miwshowopen 1:16 57 18:23:30 phideaux cast out and cold 5:15 infernal 2018 55 18:28:45 Billy Joel Falling of the Rain 2:31 Cold Spring Harbor 1971 Billy Joel Sbme Special MKTS. 53 18:31:16 Clive […]

rain booth clive infernal double vision calcaterra cold spring harbor clive nolan phideaux xavier arena the mirror lies

Justin Cooper Star Racing Monster Energy Yamalube Yamaha Team 06-19-18

Pit Pass Moto

Play Episode Listen Later Jun 19, 2018 17:20

Cooper grew up in Cold Spring Harbor, Long Island and started racing in 2002 and turned Pro in 2017. He races for the Star Racing Monster Energy Yamalube Yamaha Team. At the Lucas Oil Motocross race he went 3 – 4 for third overall. He is currently fourth overall in the 250 class points standings.

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Coalition Against an Unsound Crossing

health advice tips executive director connecticut crossing long island coalition talkshow adjunct professor tunein north shore stony brook university nassau county unsound cold spring harbor whpc

Play Episode Listen Later Jun 8, 2018 29:14

Peter Janow is a Lifelong Long Islander resident raised in Cold Spring Harbor is currently Co-founder of One Solution Consulting, Adjunct Professor at Stony Brook University, and Executive Director of the environmental group, Coalition Against an UnSound Crossing. Peter will discuss environmental, economic and other issues that need to be considered along with plans to build a major Bridge/Tunnel complex that would span Connecticut to the North Shore of Nassau County, Long Island.

Coalition Against an Unsound Crossing

health advice tips executive director connecticut crossing long island coalition talkshow adjunct professor tunein north shore stony brook university nassau county unsound cold spring harbor whpc

Play Episode Listen Later Jun 8, 2018 29:14

Peter Janow is a Lifelong Long Islander resident raised in Cold Spring Harbor is currently Co-founder of One Solution Consulting, Adjunct Professor at Stony Brook University, and Executive Director of the environmental group, Coalition Against an UnSound Crossing. Peter will discuss environmental, economic and other issues that need to be considered along with plans to build a major Bridge/Tunnel complex that would span Connecticut to the North Shore of Nassau County, Long Island.

Barbara McLintock

Discovery

Play Episode Listen Later Apr 9, 2018 26:52

Barbara McClintock’s work on the genetics of corn won her a Nobel prize in 1983. Her research on jumping genes challenged the over-simplified picture of chromosomes and DNA that Watson and Crick’s discovery has all too often been used to support. During the half century that she worked at the Cold Spring Harbor Laboratory she became something of a living legend, a pioneer in a time when women weren’t expected to take much interest in science. In that story, she made a profound discovery that her male colleagues dismissed for years, leaving her out in the cold until they finally realized that it was true and granted her a belated Nobel Prize. Philip Ball tells the story of Barbara McLintock's life and work, from her early preference for sports, for solitude, and for intellectual life, that disturbed her parents, to her meticulous research on corn. In conversation with her recent biographer, Dr Nathaniel Comfort of Johns Hopkins University, he explores the facts and the fictions that grew up around her. Philip Ball talks about the legacy of her discovery of jumping genes with Professor Greg Hannon of the Cancer Research UK Institute at Cambridge University, who spent 25 years working in the McLintock Laboratory at Cold Spring Harbor. Picture Corn Cobs, Credit: Philippe Huguen/AFP/GettyImages)

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John Adams Afternoon Commute w/ guest Sean(SMJ)

Hoax Busters: Conspiracy or just Theory?

Play Episode Listen Later Oct 19, 2017

Sean from Austin joins John and Myself(Chris) for a discussion about- DNA, Gregory Bateson, X-ray Crystallography, G-Factor, Cavendish Laboratory,Julius Robert Oppenheimer, Edward Kelley, Cold Spring Harbor, 23 and Me, Kurt Godel, Bertrand Russel, Cybernetics, Phi Beta Kappa Society, The English Language, Bruce Lee, Francis Galton, The Kennedys, John Frankenheimer, Rockets in Space, Sunset Boulevard, RKO Pictures, Rock Oil, LaBrea Tar Pits, Jack Horner, Dinosaurs, Wernher von Braun, Space, The Moon Landing Hoax, Nukes, Wolfgang Pauly, The World Set Free Book by HG Wells. Note: Seans connection drops at the end. Commute Music: Crystal Clear by Wilbert Longmire hoaxbusterscall.com

Cold Spring Harbor DNA Learning Center

science learning center cold spring harbor

Play Episode Listen Later Oct 4, 2017 27:48

Dr. Lindsay Barone is an anthropologist working at the DNA Learning Center in Cold Spring Harbor, and has spent years studying evolution acceptance and the way people learn science outside of school. She talks about a mummy that they're working with in Cold Spring Harbor.

Cold Spring Harbor DNA Learning Center